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"gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433271", "map_id": "none", "name": "Docking of Mature Replication Dependent Histone mRNA with the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433265", "map_id": "none", "name": "Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7K4N3", "map_id": "Q7K4N3", "name": "Cbp80", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022942", "map_id": "FBgn0022942", "name": "Cbp80", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3L6", "map_id": "Q9V3L6", "name": "Cbp20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022943", "map_id": "FBgn0022943", "name": "Cbp20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10429500", "map_id": "Q9V3E7", "name": "Ref1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10432253", "map_id": "Q9U1H9", "name": "sbr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433269", "map_id": "none", "name": "Mature intronless transcript derived Histone mRNA:SLBP:TAP:Aly/Ref complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10429162", "map_id": "Q9V3L6", "name": "Cbp20", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10429167", "map_id": "Q7K4N3", "name": "Cbp80", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10435732", "map_id": "none", "name": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10470941", "map_id": "none", "name": "FYN autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_113592", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10470936", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "E1JHB7", "map_id": "E1JHB7", "name": "phospho-Pvr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032006", "map_id": "FBgn0032006", "name": "phospho-Pvr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ04", "map_id": "Q9VJ04", "name": "phospho-Dmel\\CG10702", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032752", "map_id": "FBgn0032752", "name": "phospho-Dmel\\CG10702", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPU1", "map_id": "Q9VPU1", "name": "dock", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "dock", "map_id": "dock", "name": "dock", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P00528", "map_id": "P00528", "name": "Src64B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262733", "map_id": "FBgn0262733", "name": "Src64B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29370", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10470938", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10471003", "map_id": "none", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29438", "map_id": "CHEBI:15996", "name": "GTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10470998", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9NHV9", "map_id": "Q9NHV9", "name": "Vav", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040068", "map_id": "FBgn0040068", "name": "Vav", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179838", "map_id": "CHEBI:16618", "name": "PI(3,4,5)P3", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "P40792", "map_id": "P40792", "name": "RAC1_DROME", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "RAC1_DROME", "map_id": "RAC1_DROME", "name": "RAC1_DROME", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29420", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10471000", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470975", "map_id": "none", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10470972", "map_id": "none", "name": "PKCA,PKCB,PKCD,PKCZ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P13677", "map_id": "P13677", "name": "inaC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004784", "map_id": "FBgn0004784", "name": "inaC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P05130", "map_id": "P05130", "name": "Pkc53E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003091", "map_id": "FBgn0003091", "name": "Pkc53E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z9X0", "map_id": "A1Z9X0", "name": "phospho-aPKC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261854", "map_id": "FBgn0261854", "name": "phospho-aPKC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P83099", "map_id": "P83099", "name": "phospho-Pkcdelta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259680", "map_id": "FBgn0259680", "name": "phospho-Pkcdelta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470910", "map_id": "none", "name": "p-PKCA,p-PKCB,p-PKCZ,p-PKCD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433702", "map_id": "Q9W0V1", "name": "Pdk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10470954", "map_id": "none", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10470931", "map_id": "none", "name": "p-PKC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_112275", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10470952", "map_id": "none", "name": "DAG:active PKC:Ca+2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470934", "map_id": "none", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10470981", "map_id": "none", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10446693", "map_id": "Q9VYY8", "name": "Sk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030300", "map_id": "FBgn0030300", "name": "Sk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470978", "map_id": "Q9VYY8", "name": "phospho-Sk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10470994", "map_id": "none", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10470991", "map_id": "none", "name": "RASA1:p21 RAS:GTP:SPG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8IR23", "map_id": "Q8IR23", "name": "vap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003969", "map_id": "FBgn0003969", "name": "vap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1606609", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "P08646", "map_id": "P08646", "name": "RAS85D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "RAS85D", "map_id": "RAS85D", "name": "RAS85D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5218688", "map_id": "CHEBI:37550", "name": "S1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10437909", "map_id": "none", "name": "p21 RAS:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439352", "map_id": "Q8IR23", "name": "vap", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441855", "map_id": "none", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441844", "map_id": "none", "name": "eNOS:CaM:HSP90:p-AKT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8INB9", "map_id": "Q8INB9", "name": "phospho-Akt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-Akt1", "map_id": "phospho-Akt1", "name": "phospho-Akt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02828", "map_id": "P02828", "name": "Hsp83", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001233", "map_id": "FBgn0001233", "name": "Hsp83", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_71185", "map_id": "CHEBI:17627", "name": "heme", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1562550", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_76629", "map_id": "CHEBI:17621", "name": "FMN", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q27571", "map_id": "Q27571", "name": "Nos", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011676", "map_id": "FBgn0011676", "name": "Nos", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113596", "map_id": "CHEBI:16238", "name": "FAD", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10441853", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_29870", "map_id": "CHEBI:15372", "name": "BH4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440781", "map_id": "none", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440773", "map_id": "none", "name": "p-S-AKT:PDPK1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W0V1", "map_id": "Q9W0V1", "name": "Pdk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Pdk1", "map_id": "Pdk1", "name": "Pdk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10440775", "map_id": "Q8INB9", "name": "phospho-Akt1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10433704", "map_id": "none", "name": "PDPK1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10471692", "map_id": "none", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10471687", "map_id": "none", "name": "p-VAV family:PIP3:RAC1:GTP:PAK 1-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B7Z0W0", "map_id": "B7Z0W0", "name": "Pak", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267698", "map_id": "FBgn0267698", "name": "Pak", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447061", "map_id": "B7Z0W0", "name": "phospho-Pak", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10446523", "map_id": "none", "name": "PAK1,2,3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465531", "map_id": "none", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10440771", "map_id": "none", "name": "p-S-AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10471689", "map_id": "none", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10471685", "map_id": "none", "name": "2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10471703", "map_id": "none", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10471701", "map_id": "none", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10471694", "map_id": "none", "name": "VE-cadherin-Catenin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8SYP8", "map_id": "Q8SYP8", "name": "Spt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033348", "map_id": "FBgn0033348", "name": "Spt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35220", "map_id": "P35220", "name": "alpha-Cat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010215", "map_id": "FBgn0010215", "name": "alpha-Cat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07666", "map_id": "P07666", "name": "Sry-alpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003510", "map_id": "FBgn0003510", "name": "Sry-alpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJB6", "map_id": "Q9VJB6", "name": "phospho-CadN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262018", "map_id": "FBgn0262018", "name": "phospho-CadN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7PLI0", "map_id": "Q7PLI0", "name": "p120ctn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260799", "map_id": "FBgn0260799", "name": "p120ctn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18824", "map_id": "P18824", "name": "arm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "arm", "map_id": "arm", "name": "arm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471699", "map_id": "none", "name": "p-S665-VE-cadherin-Catenin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10441860", "map_id": "none", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29468", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29368", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29364", "map_id": "CHEBI:16474", "name": "NADPH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_202124", "map_id": "CHEBI:16480", "name": "NO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29366", "map_id": "CHEBI:18009", "name": "NADP+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29968", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441857", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_5693375", "map_id": "CHEBI:25682", "name": "ADMA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465459", "map_id": "none", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441880", "map_id": "Q9W0V1", "name": "Pdk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10459875", "map_id": "none", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10440881", "map_id": "none", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440860", "map_id": "none", "name": "AKT:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10440874", "map_id": "none", "name": "TORC2 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VK45", "map_id": "Q9VK45", "name": "Tor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0021796", "map_id": "FBgn0021796", "name": "Tor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V719", "map_id": "Q9V719", "name": "Sin1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033935", "map_id": "FBgn0033935", "name": "Sin1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W328", "map_id": "Q9W328", "name": "Lst8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264691", "map_id": "FBgn0264691", "name": "Lst8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWJ6", "map_id": "Q9VWJ6", "name": "rictor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031006", "map_id": "FBgn0031006", "name": "rictor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10440879", "map_id": "none", "name": "AKT:PIP3:THEM4/TRIB3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9V3Z1", "map_id": "Q9V3Z1", "name": "trbl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028978", "map_id": "FBgn0028978", "name": "trbl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441872", "map_id": "none", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441840", "map_id": "none", "name": "eNOS:CaM:HSP90", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470966", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_179856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10470963", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91634", "map_id": "P91634", "name": "Pi3K92E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Pi3K92E", "map_id": "Pi3K92E", "name": "Pi3K92E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTZ2", "map_id": "Q7KTZ2", "name": "Pi3K21B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020622", "map_id": "FBgn0020622", "name": "Pi3K21B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493673", "map_id": "none", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10464321", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10470968", "map_id": "none", "name": "p-VAV family:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470996", "map_id": "none", "name": "PAK2 binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10470880", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446517", "map_id": "none", "name": "PAK2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10470985", "map_id": "none", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470961", "map_id": "none", "name": "PAK2 autophorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10470958", "map_id": "none", "name": "VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P40793", "map_id": "P40793", "name": "Cdc42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010341", "map_id": "FBgn0010341", "name": "Cdc42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470947", "map_id": "none", "name": "VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439437", "map_id": "none", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439409", "map_id": "P49071", "name": "MAPk-Ak2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0013987", "map_id": "FBgn0013987", "name": "phospho-MAPk-Ak2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10439416", "map_id": "P49071", "name": "phospho-MAPk-Ak2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439434", "map_id": "none", "name": "Phospho-MAP kinase p38 (Mg2+ cofactor)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_29926", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "O61443", "map_id": "O61443", "name": "phospho-p38b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024846", "map_id": "FBgn0024846", "name": "phospho-p38b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P83100", "map_id": "P83100", "name": "phospho-p38c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267339", "map_id": "FBgn0267339", "name": "phospho-p38c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62618", "map_id": "O62618", "name": "phospho-p38a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015765", "map_id": "FBgn0015765", "name": "phospho-p38a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471021", "map_id": "none", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471014", "map_id": "none", "name": "HSP27 oligomer:F-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IQW5", "map_id": "Q8IQW5", "name": "HspB8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031037", "map_id": "FBgn0031037", "name": "HspB8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02574", "map_id": "P02574", "name": "Act79B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000045", "map_id": "FBgn0000045", "name": "Act79B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P83967", "map_id": "P83967", "name": "Act88F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000047", "map_id": "FBgn0000047", "name": "Act88F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P53501", "map_id": "P53501", "name": "Act57B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000044", "map_id": "FBgn0000044", "name": "Act57B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P45891", "map_id": "P45891", "name": "Arp53D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011743", "map_id": "FBgn0011743", "name": "Arp53D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10987", "map_id": "P10987", "name": "Act5C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000042", "map_id": "FBgn0000042", "name": "Act5C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10981", "map_id": "P10981", "name": "Act87E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000046", "map_id": "FBgn0000046", "name": "Act87E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449184", "map_id": "none", "name": "F-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10471019", "map_id": "Q8IQW5", "name": "phospho-HspB8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10470892", "map_id": "none", "name": "p38 MAPK activation by VEGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451571", "map_id": "none", "name": "MAP kinase p38 (Mg2+ cofactor)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10470889", "map_id": "none", "name": "VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470987", "map_id": "none", "name": "CDC42:GTP binds PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439139", "map_id": "none", "name": "CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469449", "map_id": "none", "name": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10441604", "map_id": "Q9VXE3", "name": "Rok", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0026181", "map_id": "FBgn0026181", "name": "Rok", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434906", "map_id": "none", "name": "RHOA:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P48148", "map_id": "P48148", "name": "Rho1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rho1", "map_id": "Rho1", "name": "Rho1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447647", "map_id": "none", "name": "Activated ROCK:RhoA/B/C:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VXE3", "map_id": "Q9VXE3", "name": "Rok", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464390", "map_id": "none", "name": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_351067", "map_id": "none", "name": "RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10464386", "map_id": "none", "name": "WAVE Regulatory Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VF87", "map_id": "Q9VF87", "name": "Sra-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038320", "map_id": "FBgn0038320", "name": "Sra-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MLQ0", "map_id": "Q8MLQ0", "name": "HSPC300", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0061198", "map_id": "FBgn0061198", "name": "HSPC300", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VE13", "map_id": "Q9VE13", "name": "gukh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026239", "map_id": "FBgn0026239", "name": "gukh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F2FB81", "map_id": "F2FB81", "name": "SCAR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041781", "map_id": "FBgn0041781", "name": "SCAR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P55162", "map_id": "P55162", "name": "Hem", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011771", "map_id": "FBgn0011771", "name": "Hem", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10464339", "map_id": "Q8IQE6", "name": "IRSp53", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0052082", "map_id": "FBgn0052082", "name": "IRSp53", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10464388", "map_id": "none", "name": "WRC:IRSp53/58:RAC1:GTP:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8IQE6", "map_id": "Q8IQE6", "name": "IRSp53", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470950", "map_id": "none", "name": "FYN phosphorylates PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10471107", "map_id": "none", "name": "ROCK1,ROCK2 are activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471105", "map_id": "none", "name": "RHOA:GTP:Mg2+:Activated ROCK1,ROCK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10471008", "map_id": "none", "name": "p-Y420-FYN is phosphorylated on S21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471005", "map_id": "none", "name": "Protein kinase A catalytic subunit", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209235", "map_id": "none", "name": "Phosphorylated BSK kinase transports from the cytosol to the nucleus", "reversible": "false", "notes": "Free phosphorylated Basket (BSK) kinase is now able to translocate from the cytosol to the nucleus.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_206213", "map_id": "P92208", "name": "Phospho BSK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206300", "map_id": "P92208", "name": "Phospho BSK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_209330", "map_id": "none", "name": "Phosphorylated BSK kinase and the AP-1 transcription factor, JRA:KAY, bind to CKA scaffolding protein in the nucleus", "reversible": "false", "notes": "In the nucleus, another molecule of the scaffolding protein CKA binds the phosphorylated Basket (BSK) kinase and the AP-1 transcription factor heterodimer. The latter is made up of the c-Jun ortholgue, Jun-related antigen (JRA) and the c-Fos orthologue, Kayak (KAY).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_205983", "map_id": "Q9VLT9", "name": "CKA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_206724", "map_id": "none", "name": "JRA:KAY", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P21525", "map_id": "P21525", "name": "phospho-kay", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-kay", "map_id": "phospho-kay", "name": "phospho-kay", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18289", "map_id": "P18289", "name": "phospho-Jra", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-Jra", "map_id": "phospho-Jra", "name": "phospho-Jra", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_207020", "map_id": "none", "name": "Phospho BSK:CKA:JRA:KAY", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VLT9", "map_id": "Q9VLT9", "name": "CKA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CKA", "map_id": "CKA", "name": "CKA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P92208", "map_id": "P92208", "name": "bsk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "bsk", "map_id": "bsk", "name": "bsk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_209381", "map_id": "none", "name": "AP-1 transcription factor, JRA:KAY, is phosphorylated by phosphorylated BSK kinase", "reversible": "false", "notes": "Phosphorylated Basket (BSK) kinase phosphorylates residues Ser82 and Ser92 on JRA along with residues Thr216 and Thr220 on KAY.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29358", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113582", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_206830", "map_id": "none", "name": "Phospho BSK:CKA:Phospho JRA:Phospho KAY", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_209193", "map_id": "none", "name": "Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA", "reversible": "false", "notes": "The phosphorylated AP-1 transcription factor, JRA:KAY dissociates from the scaffolding protein CKA.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_206892", "map_id": "none", "name": "Phospho BSK:CKA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_206657", "map_id": "none", "name": "Phospho JRA:Phospho KAY", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_209358", "map_id": "none", "name": "Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription", "reversible": "false", "notes": "The phosphorylated AP-1 transcription factor binds to its target genes and activates transcription. One of its target genes encodes the phosphatase Puckered (PUC) which acts as a negative regulator of the pathway as part of a negative feedback loop.In the eye, another transcriptional target, arising from the Frizzled (FZ):Dishevelled (DSH) complex activation in R3 cells, is for the Notch (N) receptor ligand Delta (DL). This will subsequently bind to its receptor N in the neighbouring R4 cell.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_209298", "map_id": "none", "name": "BSK is phosphorylated and activated by phosphorylated HEP kinase", "reversible": "false", "notes": "Basket (BSK) is phosphorylated and activated when residues Thr181 and Tyr183 (Thr183 an Tyr185 in human JNK1) are phosphorylated by dual-specificity kinase, Hemipterous (HEP).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206638", "map_id": "none", "name": "BSK:CKA:Phospho HEP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23977", "map_id": "Q23977", "name": "Phospho HEP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho HEP", "map_id": "Phospho HEP", "name": "Phospho HEP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_206913", "map_id": "none", "name": "Phospho BSK:CKA:Phospho HEP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209302", "map_id": "none", "name": "Phosphorylated BSK kinase dissociates from CKA scaffolding protein", "reversible": "false", "notes": "The phosphorylation of the scaffold protein CKA probably results in a conformational change resulting in the dissociation of the phosphorylated Basket (BSK) kinase.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206943", "map_id": "none", "name": "Phospho BSK:Phospho CKA:Phospho HEP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206789", "map_id": "none", "name": "Phospho CKA:Phospho HEP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209157", "map_id": "none", "name": "Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase", "reversible": "false", "notes": "The JUN kinase phosphatase Puckered (PUC) dephosphorylates and consequently deactivates the phosphorylated Basket (BSK) kinase. The gene that encodes PUC is a target of the AP-1 transcription factor making this interaction part of a regulatory negative feedback loop.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29372", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206251", "map_id": "P92208", "name": "BSK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_205899", "map_id": "O46122", "name": "PUC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209183", "map_id": "none", "name": "Scaffolding protein CKA binds BSK and phosphorylated HEP kinases", "reversible": "false", "notes": "The multidomain scaffolding protein, connector of kinase to AP-1 (CKA) binds phosphorylated Hemipterous (HEP) and the MAP kinase/JNK orthologue, Basket (BSK).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_205833", "map_id": "Q9VLT9", "name": "CKA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_205776", "map_id": "Q23977", "name": "Phospho HEP", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209199", "map_id": "none", "name": "CKA is phosphorylated by phosphorylated BSK kinase", "reversible": "false", "notes": "The scaffolding protein CKA is phosphorylated by phosphorylated Basket (BSK) kinase.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10439486", "map_id": "none", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438214", "map_id": "none", "name": "Cdh1:phospho-APC/C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W4H9", "map_id": "Q9W4H9", "name": "fzr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262699", "map_id": "FBgn0262699", "name": "fzr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCN6", "map_id": "Q9VCN6", "name": "Cdc16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025781", "map_id": "FBgn0025781", "name": "Cdc16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZL2", "map_id": "Q9VZL2", "name": "ida", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041147", "map_id": "FBgn0041147", "name": "ida", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W395", "map_id": "Q9W395", "name": "APC4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052707", "map_id": "FBgn0052707", "name": "APC4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS37", "map_id": "Q9VS37", "name": "Cdc27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0012058", "map_id": "FBgn0012058", "name": "Cdc27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1E5", "map_id": "Q9W1E5", "name": "mr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002791", "map_id": "FBgn0002791", "name": "mr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y165", "map_id": "Q9Y165", "name": "morgue", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027609", "map_id": "FBgn0027609", "name": "morgue", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25867", "map_id": "P25867", "name": "eff", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "eff", "map_id": "eff", "name": "eff", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXV3", "map_id": "Q9VXV3", "name": "shtd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004391", "map_id": "FBgn0004391", "name": "shtd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX25", "map_id": "Q9VX25", "name": "UBE2S", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030863", "map_id": "FBgn0030863", "name": "UBE2S", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52485", "map_id": "P52485", "name": "Ubc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015320", "map_id": "FBgn0015320", "name": "Ubc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTY6", "map_id": "Q9VTY6", "name": "vih", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264848", "map_id": "FBgn0264848", "name": "vih", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KA43", "map_id": "Q7KA43", "name": "lmgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250903", "map_id": "FBgn0250903", "name": "lmgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V831", "map_id": "Q9V831", "name": "APC10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034231", "map_id": "FBgn0034231", "name": "APC10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7L8", "map_id": "Q9I7L8", "name": "Cdc23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032863", "map_id": "FBgn0032863", "name": "Cdc23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3Y6", "map_id": "Q9W3Y6", "name": "APC7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029879", "map_id": "FBgn0029879", "name": "APC7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10427405", "map_id": "none", "name": "CCNA:p-T160-CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P23573", "map_id": "P23573", "name": "Cdk2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004107", "map_id": "FBgn0004107", "name": "Cdk2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438216", "map_id": "none", "name": "Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438221", "map_id": "none", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438218", "map_id": "none", "name": "Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438380", "map_id": "none", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438212", "map_id": "Q9W4H9", "name": "fzr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10438066", "map_id": "Q9W4H9", "name": "phospho-fzr", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10437694", "map_id": "none", "name": "CCNB1:p-T161-CDK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P23572", "map_id": "P23572", "name": "phospho-Cdk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004106", "map_id": "FBgn0004106", "name": "phospho-Cdk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20439", "map_id": "P20439", "name": "CycB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000405", "map_id": "FBgn0000405", "name": "CycB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10435471", "map_id": "none", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427579", "map_id": "none", "name": "phosphorylated anaphase promoting complex (APC/C)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10435467", "map_id": "none", "name": "hBUBR1:hBUB3:MAD2*:CDC20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VAJ2", "map_id": "Q9VAJ2", "name": "Bub3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025457", "map_id": "FBgn0025457", "name": "Bub3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6I7", "map_id": "A1Z6I7", "name": "BubR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263855", "map_id": "FBgn0263855", "name": "BubR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRQ2", "map_id": "Q9VRQ2", "name": "mad2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035640", "map_id": "FBgn0035640", "name": "mad2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24044", "map_id": "Q24044", "name": "fzy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001086", "map_id": "FBgn0001086", "name": "fzy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435469", "map_id": "none", "name": "MCC:APC/C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10435477", "map_id": "none", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435460", "map_id": "Q24044", "name": "fzy", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10435465", "map_id": "Q9VRQ2", "name": "mad2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10435450", "map_id": "A1Z6I7", "name": "BubR1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10435455", "map_id": "Q9VAJ2", "name": "Bub3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10435475", "map_id": "none", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435473", "map_id": "none", "name": "MAD2*CDC20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438247", "map_id": "none", "name": "Association of Emi1 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438243", "map_id": "none", "name": "Cdh1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10436108", "map_id": "Q9VM76", "name": "Rca1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0017551", "map_id": "FBgn0017551", "name": "phospho-Rca1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438245", "map_id": "none", "name": "Emi1:Cdh1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VM76", "map_id": "Q9VM76", "name": "phospho-Rca1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438310", "map_id": "none", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438102", "map_id": "none", "name": "phospho-Cdh1:phospho-APC/C complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10438100", "map_id": "none", "name": "phosphorylated anaphase promoting complex (APC/C)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438374", "map_id": "none", "name": "Association of Emi1 with Cdc20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438282", "map_id": "Q24044", "name": "fzy", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10438372", "map_id": "none", "name": "Emi1:Cdc20 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438361", "map_id": "none", "name": "Phosphorylation of the Emi1 DSGxxS degron by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438286", "map_id": "none", "name": "Emi1:Cdc20/Cdh1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10438359", "map_id": "none", "name": "phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10435494", "map_id": "P52304", "name": "phospho-polo", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0003124", "map_id": "FBgn0003124", "name": "phospho-polo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438294", "map_id": "none", "name": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438291", "map_id": "none", "name": "Phospho-Emi1(Ser 182):Cdc20/Cdh1 complexes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438382", "map_id": "none", "name": "Degradation multiubiquitinated Cyclin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438253", "map_id": "none", "name": "multiubiquitinated Cyclin A associated with MCC:APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P0CG69", "map_id": "P0CG69", "name": "UBI-P63E 1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "UBI-P63E 1", "map_id": "UBI-P63E 1", "name": "UBI-P63E 1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18101", "map_id": "P18101", "name": "UBI-P63E 12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "UBI-P63E 12", "map_id": "UBI-P63E 12", "name": "UBI-P63E 12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P15357", "map_id": "P15357", "name": "UBI-P63E 11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "UBI-P63E 11", "map_id": "UBI-P63E 11", "name": "UBI-P63E 11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W418", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086558", "map_id": "FBgn0086558", "name": "Ubi-p5E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434593", "map_id": "P23572", "name": "phospho-Cdk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426987", "map_id": "none", "name": "Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10427203", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V3P3", "map_id": "Q9V3P3", "name": "REG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029133", "map_id": "FBgn0029133", "name": "REG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18413", "map_id": "O18413", "name": "Rpt6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpt6", "map_id": "Rpt6", "name": "Rpt6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUJ1", "map_id": "Q9VUJ1", "name": "Prosbeta2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosbeta2", "map_id": "Prosbeta2", "name": "Prosbeta2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T915", "map_id": "Q8T915", "name": "Prosbeta2R2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037296", "map_id": "FBgn0037296", "name": "Prosbeta2R2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W470", "map_id": "Q9W470", "name": "Prosbeta2R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029812", "map_id": "FBgn0029812", "name": "Prosbeta2R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W414", "map_id": "Q9W414", "name": "Rpt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028685", "map_id": "FBgn0028685", "name": "Rpt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V637", "map_id": "Q9V637", "name": "PI31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033669", "map_id": "FBgn0033669", "name": "PI31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJJ0", "map_id": "Q9VJJ0", "name": "Prosbeta4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosbeta4", "map_id": "Prosbeta4", "name": "Prosbeta4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3P6", "map_id": "Q9V3P6", "name": "Rpn2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn2", "map_id": "Rpn2", "name": "Rpn2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XYN7", "map_id": "Q9XYN7", "name": "Prosbeta3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosbeta3", "map_id": "Prosbeta3", "name": "Prosbeta3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KLV9", "map_id": "Q7KLV9", "name": "Rpn6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn6", "map_id": "Rpn6", "name": "Rpn6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNA5", "map_id": "Q9VNA5", "name": "Prosbeta7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosbeta7", "map_id": "Prosbeta7", "name": "Prosbeta7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3Z4", "map_id": "Q9V3Z4", "name": "Rpn5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn5", "map_id": "Rpn5", "name": "Rpn5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3H2", "map_id": "Q9V3H2", "name": "Rpn11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn11", "map_id": "Rpn11", "name": "Rpn11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K148", "map_id": "Q7K148", "name": "Prosbeta5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029134", "map_id": "FBgn0029134", "name": "Prosbeta5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22769", "map_id": "P22769", "name": "Prosalpha4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosalpha4", "map_id": "Prosalpha4", "name": "Prosalpha4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27575", "map_id": "Q27575", "name": "Prosalpha4T2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017556", "map_id": "FBgn0017556", "name": "Prosalpha4T2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24178", "map_id": "Q24178", "name": "Prosalpha4T1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265606", "map_id": "FBgn0265606", "name": "Prosalpha4T1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KMP8", "map_id": "Q7KMP8", "name": "Rpn9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn9", "map_id": "Rpn9", "name": "Rpn9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P12881", "map_id": "P12881", "name": "Prosalpha6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosalpha6", "map_id": "Prosalpha6", "name": "Prosalpha6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0AQH0", "map_id": "A0AQH0", "name": "Prosbeta1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010590", "map_id": "FBgn0010590", "name": "Prosbeta1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW54", "map_id": "Q9VW54", "name": "Rpn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn1", "map_id": "Rpn1", "name": "Rpn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P40301", "map_id": "P40301", "name": "Prosalpha2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosalpha2", "map_id": "Prosalpha2", "name": "Prosalpha2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1S5", "map_id": "Q9W1S5", "name": "Prosbeta5R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034842", "map_id": "FBgn0034842", "name": "Prosbeta5R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8INY4", "map_id": "Q8INY4", "name": "Prosbeta5R2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051742", "map_id": "FBgn0051742", "name": "Prosbeta5R2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25161", "map_id": "P25161", "name": "Rpn3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn3", "map_id": "Rpn3", "name": "Rpn3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V5C6", "map_id": "Q9V5C6", "name": "Prosalpha7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosalpha7", "map_id": "Prosalpha7", "name": "Prosalpha7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P55035", "map_id": "P55035", "name": "Rpn10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn10", "map_id": "Rpn10", "name": "Rpn10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18053", "map_id": "P18053", "name": "Prosalpha3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261394", "map_id": "FBgn0261394", "name": "Prosalpha3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYG1", "map_id": "Q9VYG1", "name": "PSMD5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030457", "map_id": "FBgn0030457", "name": "PSMD5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95083", "map_id": "Q95083", "name": "Prosalpha5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosalpha5", "map_id": "Prosalpha5", "name": "Prosalpha5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3G7", "map_id": "Q9V3G7", "name": "Rpn7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn7", "map_id": "Rpn7", "name": "Rpn7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZJ4", "map_id": "Q9XZJ4", "name": "Prosalpha1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosalpha1", "map_id": "Prosalpha1", "name": "Prosalpha1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P26270", "map_id": "P26270", "name": "Rpn8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn8", "map_id": "Rpn8", "name": "Rpn8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48601", "map_id": "P48601", "name": "Rpt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpt2", "map_id": "Rpt2", "name": "Rpt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V436", "map_id": "Q9V436", "name": "Rpn12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpn12", "map_id": "Rpn12", "name": "Rpn12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KMQ0", "map_id": "Q7KMQ0", "name": "Rpt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpt1", "map_id": "Rpt1", "name": "Rpt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P40304", "map_id": "P40304", "name": "Prosbeta6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Prosbeta6", "map_id": "Prosbeta6", "name": "Prosbeta6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3V6", "map_id": "Q9V3V6", "name": "Rpt5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpt5", "map_id": "Rpt5", "name": "Rpt5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFS8", "map_id": "Q9VFS8", "name": "PSMD9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038166", "map_id": "FBgn0038166", "name": "PSMD9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V405", "map_id": "Q9V405", "name": "Rpt3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rpt3", "map_id": "Rpt3", "name": "Rpt3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438355", "map_id": "none", "name": "Association of Cyclin A with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438249", "map_id": "none", "name": "Cyclin A:phospho-Cdc2(Thr 161) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10438251", "map_id": "none", "name": "Cdc2:Cyclin A:MCC:APC/C complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438256", "map_id": "none", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10439023", "map_id": "none", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439016", "map_id": "none", "name": "Nek2A:MCC:APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W3N8", "map_id": "Q9W3N8", "name": "Nek2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029970", "map_id": "FBgn0029970", "name": "Nek2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10439020", "map_id": "none", "name": "Multiubiquitinated Nek2A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10439018", "map_id": "none", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439014", "map_id": "Q9W3N8", "name": "Nek2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10439025", "map_id": "none", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10438378", "map_id": "none", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438276", "map_id": "none", "name": "CDC20:p-APC/C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10438376", "map_id": "none", "name": "hBUBR1:hBUB3:MAD2* complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438280", "map_id": "none", "name": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437675", "map_id": "none", "name": "CCNB1:p-T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10438278", "map_id": "none", "name": "Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438325", "map_id": "none", "name": "Degradation of multiubiquitinated Cyclin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438323", "map_id": "none", "name": "multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438370", "map_id": "none", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10438366", "map_id": "none", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438318", "map_id": "none", "name": "CDC20:pAPC/C:K11polyUb-PTTG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438321", "map_id": "none", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438314", "map_id": "none", "name": "CDC20:p-APC/C:PTTG1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438308", "map_id": "none", "name": "Free APC/C phosphorylated by Cyclin B:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10438274", "map_id": "none", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10438107", "map_id": "none", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427430", "map_id": "none", "name": "Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10438104", "map_id": "none", "name": "multiubiquitinated Cdh1 associated with APC/C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438208", "map_id": "none", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438205", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438306", "map_id": "none", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29356", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438296", "map_id": "Q9W4H9", "name": "phospho-fzr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111294", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10427584", "map_id": "Q9W4H9", "name": "fzr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438303", "map_id": "none", "name": "phospho-Cdh1 phosphatase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10438210", "map_id": "none", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427586", "map_id": "none", "name": "phospho-APC/C:Cdh1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438368", "map_id": "none", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10498544", "map_id": "none", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10498541", "map_id": "none", "name": "RB1:SKP2:APC/C:Cdh1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10439482", "map_id": "none", "name": "PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438364", "map_id": "none", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438239", "map_id": "none", "name": "cell cycle proteins:phospho-APC/C:Cdh1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P52304", "map_id": "P52304", "name": "phospho-polo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKN7", "map_id": "Q9VKN7", "name": "aurB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024227", "map_id": "FBgn0024227", "name": "aurB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGF9", "map_id": "Q9VGF9", "name": "aurA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000147", "map_id": "FBgn0000147", "name": "aurA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438258", "map_id": "none", "name": "multiubiquitinated cell cycle protein:APC/C:Cdh1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438260", "map_id": "none", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10438241", "map_id": "none", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438237", "map_id": "none", "name": "(APC/C:Cdh1)-targeted cell cycle proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10472877", "map_id": "none", "name": "Active NIK phosphorylates IKKA dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472874", "map_id": "none", "name": "IKKA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VEZ5", "map_id": "Q9VEZ5", "name": "phospho-IKKbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-IKKbeta", "map_id": "phospho-IKKbeta", "name": "phospho-IKKbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446829", "map_id": "Q8MSQ4", "name": "Mekk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0024329", "map_id": "FBgn0024329", "name": "phospho-Mekk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472862", "map_id": "none", "name": "Active NIK:p-S176,180-IKKA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8MSQ4", "map_id": "Q8MSQ4", "name": "phospho-Mekk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472872", "map_id": "none", "name": "Activation of NIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10472920", "map_id": "none", "name": "26S proteasome processes p-7S-p100:RELB to form p52:RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472913", "map_id": "none", "name": "K48-polyUb-p-7S-p100:RELB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94527", "map_id": "Q94527", "name": "Rel", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rel", "map_id": "Rel", "name": "Rel", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P15330", "map_id": "P15330", "name": "dl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "dl", "map_id": "dl", "name": "dl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472918", "map_id": "none", "name": "p52:RELB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10472935", "map_id": "none", "name": "p52:RELB translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10472933", "map_id": "none", "name": "p52:RELB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10472870", "map_id": "none", "name": "p100:RELB binds active NIK:p-IKKA dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472866", "map_id": "none", "name": "p100:RELB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10472868", "map_id": "none", "name": "Active NIK:p-S176,180-IKKA dimer:p100:RELB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10472916", "map_id": "none", "name": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472890", "map_id": "none", "name": "Active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475005", "map_id": "none", "name": "Activated FGFR1 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465461", "map_id": "none", "name": "Activated FGFR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_190915", "map_id": "CHEBI:28815", "name": "HS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q9VDT9", "map_id": "Q9VDT9", "name": "bnl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014135", "map_id": "FBgn0014135", "name": "bnl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09147", "map_id": "Q09147", "name": "btl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0285896", "map_id": "FBgn0285896", "name": "btl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q07407", "map_id": "Q07407", "name": "htl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010389", "map_id": "FBgn0010389", "name": "htl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VV98", "map_id": "Q9VV98", "name": "Dmel\\CG9701", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036659", "map_id": "FBgn0036659", "name": "Dmel\\CG9701", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474909", "map_id": "Q9V3C8", "name": "Shc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0015296", "map_id": "FBgn0015296", "name": "phospho-Shc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475003", "map_id": "none", "name": "Activated FGFR1:SHC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9V3C8", "map_id": "Q9V3C8", "name": "phospho-Shc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475036", "map_id": "none", "name": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438980", "map_id": "none", "name": "p21 RAS:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475031", "map_id": "none", "name": "Activated FGFR1:p-SHC1:GRB2:SOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q08012", "map_id": "Q08012", "name": "drk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004638", "map_id": "FBgn0004638", "name": "drk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P26675", "map_id": "P26675", "name": "Sos", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Sos", "map_id": "Sos", "name": "Sos", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475033", "map_id": "none", "name": "Activated FGFR1:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10431797", "map_id": "none", "name": "GRB2-1:SOS1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10475013", "map_id": "none", "name": "Activated FGFR1:p-SHC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475016", "map_id": "none", "name": "Activated FGFR1 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10434311", "map_id": "none", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434307", "map_id": "none", "name": "PKA tetramer:4xcAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_30389", "map_id": "CHEBI:17489", "name": "cAMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q9VA47", "map_id": "Q9VA47", "name": "Dmel\\CG12069", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039796", "map_id": "FBgn0039796", "name": "Dmel\\CG12069", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P16911", "map_id": "P16911", "name": "Pka-C2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000274", "map_id": "FBgn0000274", "name": "Pka-C2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P12370", "map_id": "P12370", "name": "Pka-C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Pka-C1", "map_id": "Pka-C1", "name": "Pka-C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P81900", "map_id": "P81900", "name": "Pka-R2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022382", "map_id": "FBgn0022382", "name": "Pka-R2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P16905", "map_id": "P16905", "name": "Pka-R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259243", "map_id": "FBgn0259243", "name": "Pka-R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434309", "map_id": "none", "name": "cAMP:PKA regulatory subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10434303", "map_id": "none", "name": "PKA catalytic subunit", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10433343", "map_id": "none", "name": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77358", "map_id": "CHEBI:28002", "name": "cis,cis-3,6-Dodecadienoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77360", "map_id": "CHEBI:28387", "name": "trans,cis-Lauro-2,6-dienoyl-CoA ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10433340", "map_id": "none", "name": "DCI dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VL68", "map_id": "Q9VL68", "name": "Dmel\\CG4598", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032160", "map_id": "FBgn0032160", "name": "Dmel\\CG4598", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433820", "map_id": "none", "name": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_109994", "map_id": "CHEBI:29126", "name": "3-trans-decenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77343", "map_id": "CHEBI:10723", "name": "tdec2-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433345", "map_id": "none", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_109986", "map_id": "CHEBI:29140", "name": "4-cis-decenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_109990", "map_id": "CHEBI:29119", "name": "2-trans-4-cis-decadienoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_31649", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10433219", "map_id": "none", "name": "ACADM tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VSA3", "map_id": "Q9VSA3", "name": "ACADM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035811", "map_id": "FBgn0035811", "name": "ACADM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469608", "map_id": "none", "name": "PIAS1 SUMOylates SAFB with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469602", "map_id": "Q8IMV6", "name": "Saf-B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0039229", "map_id": "FBgn0039229", "name": "Saf-B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467300", "map_id": "none", "name": "UBE2I:SUMO2,UBE2I:SUMO3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O97102", "map_id": "O97102", "name": "smt3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264922", "map_id": "FBgn0264922", "name": "smt3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KNM2", "map_id": "Q7KNM2", "name": "lwr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010602", "map_id": "FBgn0010602", "name": "lwr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467222", "map_id": "Q7KNM2", "name": "lwr", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10469606", "map_id": "Q8IMV6", "name": "Saf-B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10454160", "map_id": "A1Z7P5", "name": "Su(var)2-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0003612", "map_id": "FBgn0003612", "name": "Su(var)2-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469156", "map_id": "none", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10429510", "map_id": "Q8MZI3", "name": "DmRH5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0035720", "map_id": "FBgn0035720", "name": "DmRH5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467290", "map_id": "none", "name": "SUMO2:UBE2I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10469153", "map_id": "Q8MZI3", "name": "DmRH5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10467491", "map_id": "none", "name": "PRC1 SUMOylates CTBP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467421", "map_id": "O46036", "name": "CtBP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0020496", "map_id": "FBgn0020496", "name": "CtBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467424", "map_id": "O46036", "name": "CtBP", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10467488", "map_id": "none", "name": "PRC1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P26017", "map_id": "P26017", "name": "Pc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003042", "map_id": "FBgn0003042", "name": "Pc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB08", "map_id": "Q9VB08", "name": "Sce", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003330", "map_id": "FBgn0003330", "name": "Sce", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHA0", "map_id": "Q9VHA0", "name": "Scm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003334", "map_id": "FBgn0003334", "name": "Scm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35820", "map_id": "P35820", "name": "Psc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005624", "map_id": "FBgn0005624", "name": "Psc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25172", "map_id": "P25172", "name": "Su(z)2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265623", "map_id": "FBgn0265623", "name": "Su(z)2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P39769", "map_id": "P39769", "name": "ph-p", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004861", "map_id": "FBgn0004861", "name": "ph-p", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKL0", "map_id": "Q9VKL0", "name": "Samuel", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032330", "map_id": "FBgn0032330", "name": "Samuel", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W523", "map_id": "Q9W523", "name": "ph-d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004860", "map_id": "FBgn0004860", "name": "ph-d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469619", "map_id": "none", "name": "SUMOylation of NPM1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469613", "map_id": "Q27415", "name": "Nlp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0016685", "map_id": "FBgn0016685", "name": "Nlp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469616", "map_id": "Q27415", "name": "Nlp", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10471853", "map_id": "none", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427633", "map_id": "none", "name": "PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P17917", "map_id": "P17917", "name": "PCNA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005655", "map_id": "FBgn0005655", "name": "PCNA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471849", "map_id": "none", "name": "MSH2:MSH6:ATP:DNA containing 1-2 base mismatch", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VUM0", "map_id": "Q9VUM0", "name": "Msh6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036486", "map_id": "FBgn0036486", "name": "Msh6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P43248", "map_id": "P43248", "name": "spel1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015546", "map_id": "FBgn0015546", "name": "spel1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471835", "map_id": "none", "name": "MLH1:PMS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A1ZA03", "map_id": "A1ZA03", "name": "Pms2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011660", "map_id": "FBgn0011660", "name": "Pms2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7C1", "map_id": "A1Z7C1", "name": "Mlh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011659", "map_id": "FBgn0011659", "name": "Mlh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471851", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471868", "map_id": "none", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5358610", "map_id": "none", "name": "DNA containing single strand nick (5' phosphate, 3' hydroxyl)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_109966", "map_id": "none", "name": "Repaired double-stranded DNA", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_164121", "map_id": "CHEBI:16027", "name": "AMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113541", "map_id": "CHEBI:29888", "name": "PPi", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10427699", "map_id": "Q9W1H4", "name": "DNAlig1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0262619", "map_id": "FBgn0262619", "name": "DNAlig1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471882", "map_id": "none", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471862", "map_id": "none", "name": "MSH2:MSH6:ADP:DNA containing 1-2 base mismatch", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471864", "map_id": "none", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471860", "map_id": "none", "name": "MSH2:MSH6:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5358514", "map_id": "none", "name": "DNA containing mismatch or 1-2 base IDL", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10471880", "map_id": "none", "name": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427667", "map_id": "none", "name": "RPA heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24492", "map_id": "Q24492", "name": "RpA-70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010173", "map_id": "FBgn0010173", "name": "RpA-70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIH1", "map_id": "Q9VIH1", "name": "RPA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032906", "map_id": "FBgn0032906", "name": "RPA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYW3", "map_id": "Q9VYW3", "name": "RPA3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266421", "map_id": "FBgn0266421", "name": "RPA3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471875", "map_id": "none", "name": "EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24558", "map_id": "Q24558", "name": "tos", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015553", "map_id": "FBgn0015553", "name": "tos", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471866", "map_id": "none", "name": "RPA:DNA containing single strand gap", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471877", "map_id": "none", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471873", "map_id": "Q24558", "name": "tos", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10471855", "map_id": "none", "name": "MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10472562", "map_id": "none", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471828", "map_id": "A1Z7C1", "name": "Mlh1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10471833", "map_id": "A1ZA03", "name": "Pms2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10471858", "map_id": "none", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10472560", "map_id": "none", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471840", "map_id": "P43248", "name": "spel1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10471845", "map_id": "Q9VUM0", "name": "Msh6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10473069", "map_id": "none", "name": "NUMB:ITCH bind and ubiquitnate GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473061", "map_id": "none", "name": "pS-GLI1:SUFU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "Q9VG38", "map_id": "Q9VG38", "name": "Su(fu)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005355", "map_id": "FBgn0005355", "name": "Su(fu)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P19538", "map_id": "P19538", "name": "ci", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ci", "map_id": "ci", "name": "ci", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473055", "map_id": "none", "name": "NUMB:ITCH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P16554", "map_id": "P16554", "name": "numb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002973", "map_id": "FBgn0002973", "name": "numb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y0H4", "map_id": "Q9Y0H4", "name": "Su(dx)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003557", "map_id": "FBgn0003557", "name": "Su(dx)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473066", "map_id": "none", "name": "NUMB:ITCH:ub-pS-GLI1:SUFU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10473111", "map_id": "none", "name": "GLI1 is degraded by the proteasome after ubiquitination by ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472994", "map_id": "Q9VG38", "name": "Su(fu)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10473109", "map_id": "none", "name": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473071", "map_id": "none", "name": "ub-pS-GLI1:SUFU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "reaction_10473073", "map_id": "none", "name": "SCF(beta-TrCP) ubiquitinates p-GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263232", "compartment_display": "ciliary base" }, { "id": "species_10442677", "map_id": "none", "name": "BTRC:CUL1:RBX1:SKP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q24311", "map_id": "Q24311", "name": "Cul1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Cul1", "map_id": "Cul1", "name": "Cul1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O77430", "map_id": "O77430", "name": "SkpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "SkpA", "map_id": "SkpA", "name": "SkpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W5E1", "map_id": "Q9W5E1", "name": "Roc1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Roc1a", "map_id": "Roc1a", "name": "Roc1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473057", "map_id": "none", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10456470", "map_id": "Q9Y0H4", "name": "Su(dx)", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10473053", "map_id": "P16554", "name": "numb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10491420", "map_id": "none", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6786250", "map_id": "CHEBI:15727", "name": "CARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71284", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71285", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8876775", "map_id": "CHEBI:18323", "name": "Anserine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10491417", "map_id": "Q9I7X6", "name": "CARNMT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0023522", "map_id": "FBgn0023522", "name": "CARNMT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10456032", "map_id": "none", "name": "Histidine is decarboxylated to histamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29612", "map_id": "CHEBI:32513", "name": "L-His", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_175992", "map_id": "CHEBI:18295", "name": "Hist", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113528", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10456029", "map_id": "none", "name": "PXLP-K305-HDC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q05733", "map_id": "Q05733", "name": "Hdc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005619", "map_id": "FBgn0005619", "name": "Hdc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464665", "map_id": "none", "name": "Extracellular KSPG translocates to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10464621", "map_id": "M9MSI4", "name": "DS05899.7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "FBgn0028872", "map_id": "FBgn0028872", "name": "DS05899.7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10461390", "map_id": "M9MSI4", "name": "DS05899.7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10460806", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605715", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105012", "map_id": "CHEBI:63852", "name": "GlcNAc-Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105010", "map_id": "CHEBI:63853", "name": "Gal-GlcNAc(S)-Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605658", "map_id": "CHEBI:28037", "name": "GalNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10460515", "map_id": "none", "name": "HEXA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9W3C4", "map_id": "Q9W3C4", "name": "Hexo2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041629", "map_id": "FBgn0041629", "name": "Hexo2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8WSF3", "map_id": "Q8WSF3", "name": "fdl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0045063", "map_id": "FBgn0045063", "name": "fdl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E8H9", "map_id": "Q0E8H9", "name": "Hexo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041630", "map_id": "FBgn0041630", "name": "Hexo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497913", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10460517", "map_id": "none", "name": "bHEXB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10460725", "map_id": "none", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2104997", "map_id": "CHEBI:63850", "name": "Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605637", "map_id": "CHEBI:28061", "name": "Gal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2104995", "map_id": "CHEBI:63851", "name": "GlcNAc(S)-Gal-GlcNAc(S)-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10460477", "map_id": "Q9VGE7", "name": "Ect3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0260746", "map_id": "FBgn0260746", "name": "Ect3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460803", "map_id": "none", "name": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1606845", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10460800", "map_id": "Q5BIL9", "name": "Dmel\\CG18278", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0033836", "map_id": "FBgn0033836", "name": "Dmel\\CG18278", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453964", "map_id": "none", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_744229", "map_id": "none", "name": "UDP-GlcNAc, UDP-Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_744227", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_914003", "map_id": "CHEBI:16264", "name": "UDP-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_735698", "map_id": "CHEBI:16695", "name": "uridine 5'-monophosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_109402", "map_id": "CHEBI:16695", "name": "UMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_744234", "map_id": "none", "name": "UDP-GlcNAc, UDP-Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10453959", "map_id": "Q95YI5", "name": "frc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0042641", "map_id": "FBgn0042641", "name": "frc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464619", "map_id": "none", "name": "Further sulfation on galactose residues produces KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_741440", "map_id": "CHEBI:17980", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10464596", "map_id": "M9MSI4", "name": "DS05899.7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_742343", "map_id": "CHEBI:17985", "name": "PAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10464606", "map_id": "M9MSI4", "name": "DS05899.7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10464616", "map_id": "Q9VMC3", "name": "Dmel\\CG31637", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0051637", "map_id": "FBgn0051637", "name": "Dmel\\CG31637", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10463991", "map_id": "none", "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10463960", "map_id": "M9MSI4", "name": "DS05899.7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10463973", "map_id": "M9MSI4", "name": "DS05899.7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_205687", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10463988", "map_id": "none", "name": "B3GNT1,2,3,4,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q95RP8", "map_id": "Q95RP8", "name": "EG:BACR37P7.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040373", "map_id": "FBgn0040373", "name": "EG:BACR37P7.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8R6", "map_id": "A1Z8R6", "name": "GalT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053145", "map_id": "FBgn0053145", "name": "GalT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8R5", "map_id": "A1Z8R5", "name": "Dmel\\CG30037", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050037", "map_id": "FBgn0050037", "name": "Dmel\\CG30037", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8R4", "map_id": "A1Z8R4", "name": "CG8976", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050036", "map_id": "FBgn0050036", "name": "CG8976", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZA6", "map_id": "Q9VZA6", "name": "BcDNA:GM04393", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035558", "map_id": "FBgn0035558", "name": "BcDNA:GM04393", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLT0", "map_id": "Q9VLT0", "name": "GalT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031986", "map_id": "FBgn0031986", "name": "GalT5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLS8", "map_id": "Q9VLS8", "name": "GalT4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031988", "map_id": "FBgn0031988", "name": "GalT4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1A7", "map_id": "Q9W1A7", "name": "BEST:GH04269", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041706", "map_id": "FBgn0041706", "name": "BEST:GH04269", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464663", "map_id": "none", "name": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10464634", "map_id": "M9MSI4", "name": "DS05899.7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10464660", "map_id": "none", "name": "CHST2,5,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VMC4", "map_id": "Q9VMC4", "name": "Dmel\\CG9550", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031826", "map_id": "FBgn0031826", "name": "Dmel\\CG9550", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMC3", "map_id": "Q9VMC3", "name": "Dmel\\CG31637", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464631", "map_id": "none", "name": "KSPG is secreted from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "reaction_10464678", "map_id": "none", "name": "B4GALTs transfer Gal to the keratan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_735682", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10464668", "map_id": "M9MSI4", "name": "DS05899.7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10455897", "map_id": "none", "name": "B4GALT1-6 homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VAQ8", "map_id": "Q9VAQ8", "name": "beta4GalNAcTB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039625", "map_id": "FBgn0039625", "name": "beta4GalNAcTB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KN92", "map_id": "Q7KN92", "name": "beta4GalNAcTA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027538", "map_id": "FBgn0027538", "name": "beta4GalNAcTA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464691", "map_id": "none", "name": "B4GALTs transfer Gal to a branch of keratan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10464681", "map_id": "M9MSI4", "name": "DS05899.7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10463970", "map_id": "none", "name": "B4GALTs transfer Gal to the N-glycan precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10463949", "map_id": "M9MSI4", "name": "DS05899.7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10440396", "map_id": "none", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_70106", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193830", "map_id": "CHEBI:48778", "name": "5beta-cholestan-7alpha,27-diol-3-one", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193842", "map_id": "CHEBI:28540", "name": "5beta-cholestan-3alpha,7alpha,26-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440094", "map_id": "none", "name": "Homologues of AKR1C4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VTL0", "map_id": "Q9VTL0", "name": "Dmel\\CG6083", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036183", "map_id": "FBgn0036183", "name": "Dmel\\CG6083", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PF61", "map_id": "M9PF61", "name": "Akr1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086254", "map_id": "FBgn0086254", "name": "Akr1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440394", "map_id": "none", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193835", "map_id": "CHEBI:48825", "name": "4CHOL7a,27DONE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10440085", "map_id": "none", "name": "Homologues of AKR1D1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440392", "map_id": "none", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9617026", "map_id": "CHEBI:48833", "name": "4CHOL7a,12a,27TONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193829", "map_id": "CHEBI:48834", "name": "5beta-cholestan-7alpha,12alpha,27-triol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440390", "map_id": "none", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29360", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192194", "map_id": "CHEBI:18431", "name": "Cholest-5-ene-3beta,7alpha,27-triol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_73473", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440112", "map_id": "Q9VVE3", "name": "Dmel\\CG7724", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0036698", "map_id": "FBgn0036698", "name": "Dmel\\CG7724", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440388", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193843", "map_id": "CHEBI:17278", "name": "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10434826", "map_id": "none", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427460", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VB62", "map_id": "Q9VB62", "name": "DNApol-alpha73", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005696", "map_id": "FBgn0005696", "name": "DNApol-alpha73", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24317", "map_id": "Q24317", "name": "DNApol-alpha50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011762", "map_id": "FBgn0011762", "name": "DNApol-alpha50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPH2", "map_id": "Q9VPH2", "name": "DNApol-alpha60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259676", "map_id": "FBgn0259676", "name": "DNApol-alpha60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P26019", "map_id": "P26019", "name": "DNApol-alpha180", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259113", "map_id": "FBgn0259113", "name": "DNApol-alpha180", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113656", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex with DNA damage", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427272", "map_id": "none", "name": "DNA polymerase alpha:primase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10439755", "map_id": "none", "name": "FGFR4 binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10439749", "map_id": "none", "name": "Homologues of FGFR4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10433467", "map_id": "Q9VDT9", "name": "bnl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10439753", "map_id": "none", "name": "FGFR4 homodimer bound to FGF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458927", "map_id": "none", "name": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458922", "map_id": "none", "name": "FGFR4:HS:KLB:FGF19", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10433616", "map_id": "none", "name": "Activated FGFR4 bound to FGF19:BetaKlotho", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458924", "map_id": "none", "name": "FGFR4 binds HS:KLB:FGF19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433610", "map_id": "Q9VDT9", "name": "bnl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10433614", "map_id": "Q9VV98", "name": "Dmel\\CG9701", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10439762", "map_id": "none", "name": "Autocatalytic phosphorylation of FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10433612", "map_id": "none", "name": "Activated FGFR4 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474842", "map_id": "none", "name": "Activated FGFR4 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439290", "map_id": "Q9VXH3", "name": "sl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0003416", "map_id": "FBgn0003416", "name": "sl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465485", "map_id": "none", "name": "Activated FGFR4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474831", "map_id": "none", "name": "activated FGFR4:PLCG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VXH3", "map_id": "Q9VXH3", "name": "sl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474836", "map_id": "none", "name": "Activated FGFR4 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474833", "map_id": "none", "name": "activated FGFR4:p-4Y-PLCG1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474848", "map_id": "none", "name": "p-4Y-PLCG1 dissociates from activated FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10441915", "map_id": "Q9VXH3", "name": "phospho-sl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10475119", "map_id": "none", "name": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438945", "map_id": "none", "name": "GRB2:GAB1:PIK3R1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VZZ9", "map_id": "Q9VZZ9", "name": "phospho-dos", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016794", "map_id": "FBgn0016794", "name": "phospho-dos", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465487", "map_id": "none", "name": "Activated FGFR4:p-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VLL4", "map_id": "Q9VLL4", "name": "phospho-Dmel\\CG13398", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032042", "map_id": "FBgn0032042", "name": "phospho-Dmel\\CG13398", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465489", "map_id": "none", "name": "Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475132", "map_id": "none", "name": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475128", "map_id": "none", "name": "Activated FGFR4:p-FRS2:p-PTPN11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475130", "map_id": "none", "name": "Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475188", "map_id": "none", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465491", "map_id": "none", "name": "Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10438947", "map_id": "none", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431812", "map_id": "Q7KTZ2", "name": "Pi3K21B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438839", "map_id": "none", "name": "GRB2:GAB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475185", "map_id": "none", "name": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475182", "map_id": "none", "name": "Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475103", "map_id": "none", "name": "Activated FGFR4 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474997", "map_id": "Q9VLL4", "name": "Dmel\\CG13398", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10475101", "map_id": "none", "name": "Activated FGFR4:FRS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475117", "map_id": "none", "name": "Activated FGFR4 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475112", "map_id": "none", "name": "Activated FGFR4:p-FRS:PTPN11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475114", "map_id": "none", "name": "Activated FGFR4:p-FRS:p-PTPN11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475126", "map_id": "none", "name": "Activated FGFR4:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475110", "map_id": "none", "name": "Activated FGFR4:p-FRS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475121", "map_id": "none", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474949", "map_id": "none", "name": "Activated FGFR4 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474873", "map_id": "Q9VLL4", "name": "Dmel\\CG13398", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10474941", "map_id": "none", "name": "Activated FGFR4:FRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475108", "map_id": "none", "name": "Activated FGFR4 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475105", "map_id": "none", "name": "Activated FGFR4:p-FRS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475124", "map_id": "none", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474946", "map_id": "none", "name": "Activated FGFR4 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474944", "map_id": "none", "name": "Activated FGFR4:p-8T-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10493199", "map_id": "none", "name": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474959", "map_id": "none", "name": "Activated FGFR4 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474957", "map_id": "none", "name": "Activated FGFR4:SHC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474955", "map_id": "none", "name": "Activated FGFR4:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474951", "map_id": "none", "name": "Activated FGFR4:pY-SHC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474953", "map_id": "none", "name": "Activated FGFR4:pY-SHC1:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474965", "map_id": "none", "name": "Activated FGFR4 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474962", "map_id": "none", "name": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475194", "map_id": "none", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439154", "map_id": "none", "name": "p-Y371-CBL:GRB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSK2", "map_id": "Q9VSK2", "name": "Cbl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020224", "map_id": "FBgn0020224", "name": "Cbl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475157", "map_id": "none", "name": "Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475162", "map_id": "none", "name": "CBL ubiquitinates FRS2 and FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475159", "map_id": "none", "name": "Ub-Activated FGFR4 complex:Ub-p-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458638", "map_id": "none", "name": "SPRY2 is serine phosphorylated in response to MAPK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458630", "map_id": "none", "name": "SPRY2:B-RAF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P11346", "map_id": "P11346", "name": "Raf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Raf", "map_id": "Raf", "name": "Raf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44783", "map_id": "O44783", "name": "phospho-sty", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014388", "map_id": "FBgn0014388", "name": "phospho-sty", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458603", "map_id": "none", "name": "S111/S120 p-SPRY2:B-RAF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10458636", "map_id": "none", "name": "p-T,Y MAPK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P40417", "map_id": "P40417", "name": "phospho-rl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003256", "map_id": "FBgn0003256", "name": "phospho-rl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458605", "map_id": "none", "name": "B-RAF dissociates from S111/S120 p-SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458599", "map_id": "O44783", "name": "phospho-sty", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458601", "map_id": "P11346", "name": "Raf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10458620", "map_id": "none", "name": "SPRY2 binds CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439032", "map_id": "Q9VSK2", "name": "Cbl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458607", "map_id": "none", "name": "PP2A(A:C):Y55/Y227-pSPRY2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P23696", "map_id": "P23696", "name": "mts", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "mts", "map_id": "mts", "name": "mts", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36179", "map_id": "P36179", "name": "Pp2A-29B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Pp2A-29B", "map_id": "Pp2A-29B", "name": "Pp2A-29B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10455248", "map_id": "none", "name": "Y55/Y227-pSPRY2:CBL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10455223", "map_id": "none", "name": "PP2A (A:C)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10455243", "map_id": "none", "name": "SPRY2 is phosphorylated by phosphorylated MNK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455225", "map_id": "none", "name": "PP2A(A:C):SPRY2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10455231", "map_id": "none", "name": "PP2A(A:C):S112/S121-pSPRY2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10455240", "map_id": "Q9VGI4", "name": "phospho-Lk6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0017581", "map_id": "FBgn0017581", "name": "phospho-Lk6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458618", "map_id": "none", "name": "CBL dissociates from ubiquitinated p-SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455250", "map_id": "none", "name": "Ub:Y55/Y227-pSPRY2:CBL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10458616", "map_id": "none", "name": "Ub-(Y55/Y227)p-SPRY2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458614", "map_id": "none", "name": "SPRY2 binds GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431791", "map_id": "Q08012", "name": "drk", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458612", "map_id": "none", "name": "PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10455253", "map_id": "none", "name": "Phosphorylated SPRY2 is ubiquitinated by CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10458628", "map_id": "none", "name": "PPA2A dephosphorylates SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458625", "map_id": "none", "name": "PPA2A (A:C):S112/S115 p-SPRY2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10458593", "map_id": "none", "name": "PPA2A(A:C):SPRY2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10458595", "map_id": "none", "name": "SPRY2 translocates to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10458609", "map_id": "none", "name": "SRC phosphorylates SPRY2 on Y55 and Y227", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438975", "map_id": "P00528", "name": "Src64B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10474993", "map_id": "none", "name": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10466163", "map_id": "none", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10466159", "map_id": "none", "name": "Condensin I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V3A7", "map_id": "Q9V3A7", "name": "glu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015391", "map_id": "FBgn0015391", "name": "glu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z987", "map_id": "A1Z987", "name": "phospho-Cap-G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259876", "map_id": "FBgn0259876", "name": "phospho-Cap-G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIP9", "map_id": "Q9VIP9", "name": "phospho-barr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014127", "map_id": "FBgn0014127", "name": "phospho-barr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAJ1", "map_id": "Q9VAJ1", "name": "phospho-Cap-D2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039680", "map_id": "FBgn0039680", "name": "phospho-Cap-D2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KK96", "map_id": "Q7KK96", "name": "SMC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027783", "map_id": "FBgn0027783", "name": "SMC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10466149", "map_id": "none", "name": "CK2 Phosphorylated Condensin I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10441790", "map_id": "none", "name": "Casein kinase II", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P08182", "map_id": "P08182", "name": "CkIIbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CkIIbeta", "map_id": "CkIIbeta", "name": "CkIIbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P08181", "map_id": "P08181", "name": "CkIIalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CkIIalpha", "map_id": "CkIIalpha", "name": "CkIIalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466161", "map_id": "none", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2529006", "map_id": "none", "name": "Unknown Phosphatase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10435527", "map_id": "none", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10435521", "map_id": "Q9VVA6", "name": "nudC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0021768", "map_id": "FBgn0021768", "name": "nudC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435525", "map_id": "Q9VVA6", "name": "phospho-nudC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10435513", "map_id": "P52304", "name": "phospho-polo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10466047", "map_id": "none", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10466044", "map_id": "none", "name": "Sister Chromosomal Arms:Ac-Cohesin:PDS5:CDCA5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "A1Z8S6", "map_id": "A1Z8S6", "name": "pds5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260012", "map_id": "FBgn0260012", "name": "pds5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCD8", "map_id": "Q9VCD8", "name": "SMC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040283", "map_id": "FBgn0040283", "name": "SMC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96689", "map_id": "O96689", "name": "phospho-vtd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260987", "map_id": "FBgn0260987", "name": "phospho-vtd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM62", "map_id": "Q9VM62", "name": "phospho-SA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020616", "map_id": "FBgn0020616", "name": "phospho-SA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0F4", "map_id": "Q9W0F4", "name": "SA-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0043865", "map_id": "FBgn0043865", "name": "SA-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXE9", "map_id": "Q9VXE9", "name": "SMC3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015615", "map_id": "FBgn0015615", "name": "SMC3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W517", "map_id": "Q9W517", "name": "wapl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004655", "map_id": "FBgn0004655", "name": "wapl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465943", "map_id": "none", "name": "Sister Chromosomal Arms:Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10437723", "map_id": "none", "name": "CCNB1,CCNB2:p-T161-CDK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465958", "map_id": "none", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10465955", "map_id": "none", "name": "Sister Chromosomal Arms:p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "true" }, { "id": "species_10437677", "map_id": "P52304", "name": "polo", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465193", "map_id": "none", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465179", "map_id": "Q9VUB8", "name": "endos", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0061515", "map_id": "FBgn0061515", "name": "phospho-endos", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465182", "map_id": "Q9VUB8", "name": "phospho-endos", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10465190", "map_id": "Q95TN8", "name": "phospho-gwl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0260399", "map_id": "FBgn0260399", "name": "phospho-gwl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465827", "map_id": "none", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465822", "map_id": "Q9VUB8", "name": "endos", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10465825", "map_id": "Q9VUB8", "name": "phospho-endos", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10467211", "map_id": "none", "name": "CDK1 phosphorylates NUP98", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467195", "map_id": "none", "name": "Nuclear Pore Complex (p-2S,3T-NUP98)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10471162", "map_id": "none", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471135", "map_id": "none", "name": "p-S395-Lamin dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q03427", "map_id": "Q03427", "name": "LamC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010397", "map_id": "FBgn0010397", "name": "LamC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P08928", "map_id": "P08928", "name": "Lam", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002525", "map_id": "FBgn0002525", "name": "Lam", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471160", "map_id": "none", "name": "p-S22/23, S395-Lamin dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10470742", "map_id": "none", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469763", "map_id": "Q8SXP0", "name": "Lpin", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "FBgn0263593", "map_id": "FBgn0263593", "name": "Lpin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469757", "map_id": "Q8SXP0", "name": "phospho-Lpin", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469782", "map_id": "none", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_113518", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113550", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10469779", "map_id": "none", "name": "CTDNEP1:CNEP1R1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q9VRG7", "map_id": "Q9VRG7", "name": "Dd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029067", "map_id": "FBgn0029067", "name": "Dd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T0B1", "map_id": "Q8T0B1", "name": "CNEP1R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036090", "map_id": "FBgn0036090", "name": "CNEP1R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471029", "map_id": "none", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_5221122", "map_id": "CHEBI:29089", "name": "1,2-diacyl-glycerol 3-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_5221124", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10445787", "map_id": "none", "name": "CCNB1:p-T160-CDK1 phosphorylates NUMA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10445775", "map_id": "none", "name": "NUMA1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VGE4", "map_id": "Q9VGE4", "name": "phospho-GCC185", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037979", "map_id": "FBgn0037979", "name": "phospho-GCC185", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IR55", "map_id": "Q8IR55", "name": "phospho-mud", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002873", "map_id": "FBgn0002873", "name": "phospho-mud", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445785", "map_id": "none", "name": "p-T2055-NUMA1 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10465453", "map_id": "none", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10465445", "map_id": "none", "name": "p-T216,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9W289", "map_id": "Q9W289", "name": "GM130", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034697", "map_id": "FBgn0034697", "name": "GM130", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW57", "map_id": "Q9VW57", "name": "Grasp65", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036919", "map_id": "FBgn0036919", "name": "Grasp65", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18332", "map_id": "O18332", "name": "Rab1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0285937", "map_id": "FBgn0285937", "name": "Rab1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465450", "map_id": "none", "name": "p-T216,S189,S274,S373-GORASP1:p-S37-GOLGA2:p-RAB1:GTP:p-T210-PLK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10465713", "map_id": "none", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10465698", "map_id": "none", "name": "GORASP2:BLZF1:RAB2A:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VHE3", "map_id": "Q9VHE3", "name": "Dmel\\CG9356", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037688", "map_id": "FBgn0037688", "name": "Dmel\\CG9356", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18333", "map_id": "O18333", "name": "Rab2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014009", "map_id": "FBgn0014009", "name": "Rab2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465704", "map_id": "none", "name": "p-T222,225-GORASP2:BLZF1:RAB2A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10465710", "map_id": "none", "name": "p-Y204-MAPK3-3/p-T185,Y187-MAPK1 homodimer", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465820", "map_id": "none", "name": "MCPH1 sequesters condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10450944", "map_id": "P53997", "name": "Set", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0014879", "map_id": "FBgn0014879", "name": "Set", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465223", "map_id": "none", "name": "Condensin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VMQ4", "map_id": "Q9VMQ4", "name": "Cap-D3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051989", "map_id": "FBgn0051989", "name": "Cap-D3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8INL2", "map_id": "Q8INL2", "name": "Cap-H2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037831", "map_id": "FBgn0037831", "name": "Cap-H2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465816", "map_id": "E1JH39", "name": "MCPH1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0260959", "map_id": "FBgn0260959", "name": "MCPH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465818", "map_id": "none", "name": "Condensin II:MCPH1:SET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "E1JH39", "map_id": "E1JH39", "name": "MCPH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P53997", "map_id": "P53997", "name": "Set", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498393", "map_id": "none", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467266", "map_id": "Q8MQX9", "name": "Ankle2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0028343", "map_id": "FBgn0028343", "name": "Ankle2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10455162", "map_id": "none", "name": "PP2A (Aalpha:B55alpha:Calpha)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P36872", "map_id": "P36872", "name": "tws", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "tws", "map_id": "tws", "name": "tws", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498391", "map_id": "none", "name": "ANKLE2:PP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8MQX9", "map_id": "Q8MQX9", "name": "Ankle2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497739", "map_id": "none", "name": "LBR binds KPNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10497735", "map_id": "Q8MLV1", "name": "phospho-LBR", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "FBgn0034657", "map_id": "FBgn0034657", "name": "LBR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10443115", "map_id": "O18388", "name": "Fs(2)Ket", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0262743", "map_id": "FBgn0262743", "name": "Fs(2)Ket", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497737", "map_id": "none", "name": "p-S71,S86-LBR:KPNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "O18388", "map_id": "O18388", "name": "Fs(2)Ket", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MLV1", "map_id": "Q8MLV1", "name": "LBR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497741", "map_id": "none", "name": "CDK1 phosphorylates LBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440460", "map_id": "Q8MLV1", "name": "LBR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10467280", "map_id": "none", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467276", "map_id": "none", "name": "VRK1,(VRK2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KRY6", "map_id": "Q7KRY6", "name": "ball", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027889", "map_id": "FBgn0027889", "name": "ball", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KMI3", "map_id": "Q7KMI3", "name": "BcDNA.LD23371", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027504", "map_id": "FBgn0027504", "name": "BcDNA.LD23371", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467278", "map_id": "none", "name": "ANKLE2:VRK1/VRK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10498422", "map_id": "none", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498413", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q8I0P1", "map_id": "Q8I0P1", "name": "spas", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039141", "map_id": "FBgn0039141", "name": "spas", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKJ9", "map_id": "Q9VKJ9", "name": "l(2)gd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261983", "map_id": "FBgn0261983", "name": "l(2)gd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRY6", "map_id": "Q9VRY6", "name": "Ist1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035715", "map_id": "FBgn0035715", "name": "Ist1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JRE4", "map_id": "Q7JRE4", "name": "MAN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034962", "map_id": "FBgn0034962", "name": "MAN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y124", "map_id": "Q9Y124", "name": "BcDNA.GH08385", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027565", "map_id": "FBgn0027565", "name": "BcDNA.GH08385", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T0Q4", "map_id": "Q8T0Q4", "name": "shrb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086656", "map_id": "FBgn0086656", "name": "shrb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VN02", "map_id": "Q9VN02", "name": "Vps24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037231", "map_id": "FBgn0037231", "name": "Vps24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRJ5", "map_id": "Q9VRJ5", "name": "CHMP2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035589", "map_id": "FBgn0035589", "name": "CHMP2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBI3", "map_id": "Q9VBI3", "name": "Vps2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039402", "map_id": "FBgn0039402", "name": "Vps2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W236", "map_id": "Q9W236", "name": "Vps20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034744", "map_id": "FBgn0034744", "name": "Vps20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498418", "map_id": "Q9Y162", "name": "Vps4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0283469", "map_id": "FBgn0283469", "name": "Vps4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498420", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q9Y162", "map_id": "Q9Y162", "name": "Vps4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498424", "map_id": "none", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10498409", "map_id": "none", "name": "LEMD2:ESCRT-III:IST1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_10498405", "map_id": "Q9VKJ9", "name": "l(2)gd1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10498411", "map_id": "none", "name": "LEM2D:ESCRT-III:IST1:CC2D1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10498426", "map_id": "none", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498400", "map_id": "Q8I0P1", "name": "spas", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10497749", "map_id": "none", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10442325", "map_id": "none", "name": "RAN:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VZ23", "map_id": "Q9VZ23", "name": "Ran", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020255", "map_id": "FBgn0020255", "name": "Ran", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472625", "map_id": "none", "name": "RAN:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10497746", "map_id": "P25171", "name": "Rcc1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "FBgn0002638", "map_id": "FBgn0002638", "name": "Rcc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497641", "map_id": "none", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497596", "map_id": "none", "name": "Nup107-160 complex:AHCTF1:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VWE6", "map_id": "Q9VWE6", "name": "Elys", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031052", "map_id": "FBgn0031052", "name": "Elys", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432171", "map_id": "Q9W1X4", "name": "Nup214", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10497639", "map_id": "none", "name": "POM121:Nup107-160 complex:AHCTF1:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10497753", "map_id": "none", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9624879", "map_id": "none", "name": "Nuclear envelope vesicle", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10497751", "map_id": "none", "name": "RAN:GTP:Nuclear envelope vesicles", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10497598", "map_id": "none", "name": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2537690", "map_id": "none", "name": "Chromatin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_1598585", "compartment_display": "chromosome", "complex": "false" }, { "id": "species_10497594", "map_id": "Q9VWE6", "name": "Elys", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10432219", "map_id": "none", "name": "Nup107-160 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10436113", "map_id": "none", "name": "Down Regulation of Emi1 through Phosphorylation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10436111", "map_id": "Q9VM76", "name": "phospho-Rca1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10466038", "map_id": "none", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10466008", "map_id": "none", "name": "Cohesin Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10466010", "map_id": "A1Z8S6", "name": "pds5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10466014", "map_id": "Q9W517", "name": "wapl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10466016", "map_id": "none", "name": "Cohesin:PDS5:WAPAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10466067", "map_id": "none", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1598585", "compartment_display": "chromosome" }, { "id": "species_10466059", "map_id": "none", "name": "NIPBL:MAU2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7PLI2", "map_id": "Q7PLI2", "name": "Nipped-B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026401", "map_id": "FBgn0026401", "name": "Nipped-B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFC0", "map_id": "Q9VFC0", "name": "Mau2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038300", "map_id": "FBgn0038300", "name": "Mau2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10466065", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:NIPBL:MAU2:Chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10435497", "map_id": "none", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10435484", "map_id": "Q9VZF5", "name": "pav", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0011692", "map_id": "FBgn0011692", "name": "pav", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435488", "map_id": "Q9VZF5", "name": "phospho-pav", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10435542", "map_id": "none", "name": "Regulation of KIF20A (MKL2) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10435537", "map_id": "Q9V877", "name": "sub", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0003545", "map_id": "FBgn0003545", "name": "sub", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435540", "map_id": "Q9V877", "name": "phospho-sub", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10448542", "map_id": "none", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428256", "map_id": "CHEBI:17761", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428193", "map_id": "CHEBI:16393", "name": "SPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428198", "map_id": "CHEBI:9254", "name": "STEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17941", "compartment_display": "early endosome", "complex": "false" }, { "id": "species_10448539", "map_id": "Q9VIP7", "name": "bwa", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0045064", "map_id": "FBgn0045064", "name": "bwa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478169", "map_id": "none", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5693768", "map_id": "CHEBI:85781", "name": "2HCERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10478166", "map_id": "Q8SXY2", "name": "fa2h", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0050502", "map_id": "FBgn0050502", "name": "fa2h", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448537", "map_id": "none", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428163", "map_id": "CHEBI:16566", "name": "SPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_428275", "map_id": "CHEBI:16893", "name": "SPAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448534", "map_id": "none", "name": "SPHK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VYY8", "map_id": "Q9VYY8", "name": "Sk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZW0", "map_id": "Q9VZW0", "name": "Sk2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052484", "map_id": "FBgn0052484", "name": "Sk2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448919", "map_id": "none", "name": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10448902", "map_id": "none", "name": "CERT:PPM1L:VAPA/B trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9W4N8", "map_id": "Q9W4N8", "name": "Vap33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029687", "map_id": "FBgn0029687", "name": "Vap33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZ28", "map_id": "Q9XZ28", "name": "Dmel\\CG7115", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027515", "map_id": "FBgn0027515", "name": "Dmel\\CG7115", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y128", "map_id": "Q9Y128", "name": "phospho-cert", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027569", "map_id": "FBgn0027569", "name": "phospho-cert", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10448900", "map_id": "none", "name": "ceramide:CERT:PPM1L:VAPA/B trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_429807", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10498667", "map_id": "none", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428203", "map_id": "CHEBI:37550", "name": "S1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_419305", "map_id": "CHEBI:37550", "name": "S1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10498664", "map_id": "Q9GQQ0", "name": "spin", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0086676", "map_id": "FBgn0086676", "name": "spin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448914", "map_id": "none", "name": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448912", "map_id": "Q9Y128", "name": "cert", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448891", "map_id": "none", "name": "PPM1L:VAPA/B dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10448498", "map_id": "none", "name": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200736", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9695889", "map_id": "CHEBI:15525", "name": "PALM-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_76194", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428182", "map_id": "CHEBI:17862", "name": "3-ketosphinganine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10448490", "map_id": "none", "name": "SPTLC complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q6NR46", "map_id": "Q6NR46", "name": "Spt-I", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086532", "map_id": "FBgn0086532", "name": "Spt-I", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3F2", "map_id": "Q9V3F2", "name": "lace", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002524", "map_id": "FBgn0002524", "name": "lace", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYH6", "map_id": "A8DYH6", "name": "Dmel\\CG34194", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085223", "map_id": "FBgn0085223", "name": "Dmel\\CG34194", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10448496", "map_id": "Q9VP04", "name": "ORMDL", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0037110", "map_id": "FBgn0037110", "name": "ORMDL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448464", "map_id": "none", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448461", "map_id": "Q9VBU5", "name": "Dmel\\CG10425", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0039304", "map_id": "FBgn0039304", "name": "Dmel\\CG10425", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448656", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_109276", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_109277", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_428662", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10448653", "map_id": "Q9V576", "name": "wun", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0016078", "map_id": "FBgn0016078", "name": "wun", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498672", "map_id": "none", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448532", "map_id": "none", "name": "Homologues of SPHK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10498670", "map_id": "none", "name": "SPHK2:SPHK2 inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10448909", "map_id": "none", "name": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_428270", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10448907", "map_id": "Q9VC05", "name": "Osbp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0020626", "map_id": "FBgn0020626", "name": "Osbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448556", "map_id": "none", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10448523", "map_id": "none", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_428248", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_8934421", "map_id": "CHEBI:9254", "name": "STEA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10448520", "map_id": "Q9VIP7", "name": "bwa", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10495317", "map_id": "none", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8959490", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8959486", "map_id": "CHEBI:17761", "name": "CERA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_8959463", "map_id": "CHEBI:73204", "name": "CPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10495314", "map_id": "Q9VS60", "name": "SMSr", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0052380", "map_id": "FBgn0052380", "name": "SMSr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448553", "map_id": "none", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428126", "map_id": "CHEBI:31488", "name": "DHCE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_9025544", "map_id": "CHEBI:31998", "name": "N-acylphytosphingosine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10448547", "map_id": "Q94515", "name": "ifc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0001941", "map_id": "FBgn0001941", "name": "ifc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448648", "map_id": "none", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428686", "map_id": "CHEBI:17553", "name": "PETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_428663", "map_id": "CHEBI:17600", "name": "HXAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448643", "map_id": "Q9V7Y2", "name": "Sply", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0010591", "map_id": "FBgn0010591", "name": "Sply", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448711", "map_id": "none", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428682", "map_id": "CHEBI:16393", "name": "SPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448708", "map_id": "none", "name": "PPAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9V576", "map_id": "Q9V576", "name": "wun", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNT8", "map_id": "Q9VNT8", "name": "WUN-like", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037341", "map_id": "FBgn0037341", "name": "WUN-like", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNU1", "map_id": "Q9VNU1", "name": "WUN-like", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNU0", "map_id": "Q9VNU0", "name": "LPP-like", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037165", "map_id": "FBgn0037165", "name": "LPP-like", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KGH1", "map_id": "Q7KGH1", "name": "wun2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041087", "map_id": "FBgn0041087", "name": "wun2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNT9", "map_id": "Q9VNT9", "name": "WUN-like", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNU2", "map_id": "Q9VNU2", "name": "laza", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037163", "map_id": "FBgn0037163", "name": "laza", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448550", "map_id": "none", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428206", "map_id": "none", "name": "NAD(P)H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_29362", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_428218", "map_id": "none", "name": "NAD(P)+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_427523", "map_id": "CHEBI:57540", "name": "NAD+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10448646", "map_id": "none", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428671", "map_id": "CHEBI:17585", "name": "HD2NAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10448932", "map_id": "none", "name": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448923", "map_id": "Q9Y128", "name": "phospho-cert", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448927", "map_id": "none", "name": "multiphospho-CERT:PPM1L:VAPA/B trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10448515", "map_id": "none", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428139", "map_id": "CHEBI:15541", "name": "ST-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448504", "map_id": "Q9W423", "name": "schlank", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0040918", "map_id": "FBgn0040918", "name": "schlank", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448930", "map_id": "none", "name": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474424", "map_id": "none", "name": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10474422", "map_id": "none", "name": "p6S, T-SMO dimer:CSNK1A1:ADRBK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "P32865", "map_id": "P32865", "name": "phospho-Gprk1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260798", "map_id": "FBgn0260798", "name": "phospho-Gprk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYN5", "map_id": "Q9VYN5", "name": "Dmel\\CG2577", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030384", "map_id": "FBgn0030384", "name": "Dmel\\CG2577", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJC2", "map_id": "Q9VJC2", "name": "Dmel\\CG7094", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032650", "map_id": "FBgn0032650", "name": "Dmel\\CG7094", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JWT4", "map_id": "Q7JWT4", "name": "CKIalpha like", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037325", "map_id": "FBgn0037325", "name": "CKIalpha like", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54367", "map_id": "P54367", "name": "CkIalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CkIalpha", "map_id": "CkIalpha", "name": "CkIalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91682", "map_id": "P91682", "name": "phospho-smo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-smo", "map_id": "phospho-smo", "name": "phospho-smo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474420", "map_id": "none", "name": "p6S, T-SMO dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "species_10474409", "map_id": "none", "name": "Homologues of CSNK1A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "species_10474399", "map_id": "P32865", "name": "Gprk1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "reaction_10497842", "map_id": "none", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10497827", "map_id": "none", "name": "PDPK1:PIP3:pS, p-T410 PRKCZ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10497840", "map_id": "none", "name": "PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10497830", "map_id": "none", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10497822", "map_id": "none", "name": "PDPK1:PIP3:p-T410-PRKCZ", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10497846", "map_id": "none", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458634", "map_id": "none", "name": "p-T185,Y187 MAPK1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10440931", "map_id": "none", "name": "p-Y185,Y187 MAPK1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10497844", "map_id": "none", "name": "PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10497849", "map_id": "none", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10449671", "map_id": "none", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_445829", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_111793", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_266099", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_445832", "map_id": "none", "name": "Divalent metals transported by NRAMP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "species_1470067", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10449668", "map_id": "P49283", "name": "Mvl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "FBgn0011672", "map_id": "FBgn0011672", "name": "Mvl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449893", "map_id": "none", "name": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441081", "map_id": "Q9VWW0", "name": "CrebB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0265784", "map_id": "FBgn0265784", "name": "phospho-CrebB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441084", "map_id": "Q9VWW0", "name": "phospho-CrebB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10449875", "map_id": "Q9VR61", "name": "phospho-S6kII", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0262866", "map_id": "FBgn0262866", "name": "S6kII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497038", "map_id": "none", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497030", "map_id": "Q9VR61", "name": "phospho-S6kII", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10450823", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159450", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113521", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113548", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10450820", "map_id": "none", "name": "PPA2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O77460", "map_id": "O77460", "name": "Nurf-38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016687", "map_id": "FBgn0016687", "name": "Nurf-38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_109496", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_390087", "map_id": "none", "name": "WTS binds to SAV", "reversible": "false", "notes": "The serine/threonine kinase, Warts (WTS), binds to the WW domain of the scaffolding protein Salvador (SAV). Hippo (HPO) kinase homodimer and WTS bind to different portions of SAV and the three proteins form a ternary complex.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_451812", "map_id": "none", "name": "HPO dimer:SAV", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VCR6", "map_id": "Q9VCR6", "name": "SAV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "SAV", "map_id": "SAV", "name": "SAV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T0S6", "map_id": "Q8T0S6", "name": "HPO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "HPO", "map_id": "HPO", "name": "HPO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_390037", "map_id": "Q9VA38", "name": "WTS", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_451836", "map_id": "none", "name": "HPO dimer:SAV:WTS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VA38", "map_id": "Q9VA38", "name": "WTS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WTS", "map_id": "WTS", "name": "WTS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_390145", "map_id": "none", "name": "Phosphorylated HPO dimer phosphorylates SAV", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase homodimer phosphorylates the scaffolding Salvador (SAV) at unknown residues.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_451829", "map_id": "none", "name": "MATS:Phospho HPO dimer:SAV:WTS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95RA8", "map_id": "Q95RA8", "name": "MATS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "MATS", "map_id": "MATS", "name": "MATS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_451860", "map_id": "none", "name": "MATS:Phospho HPO dimer:Phospho SAV:WTS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_390112", "map_id": "none", "name": "Phosphorylated HPO dimer phosphorylates WTS", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase homodimer phosphorylates Warts (WTS) kinase at unknown residues.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390172", "map_id": "none", "name": "MATS:Phospho HPO dimer:Phospho SAV:Phospho WTS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_390035", "map_id": "none", "name": "HPO dimer autophosphorylates", "reversible": "false", "notes": "The Hippo (HPO) serine/threonine kinase homodimer autophosphorylates on unknown residues and is activated. The scaffolding protein Salvador (SAV) appears to modestly increase the ability of HPO to autophosphorylate.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_451805", "map_id": "none", "name": "MATS:HPO dimer:SAV:WTS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_390124", "map_id": "none", "name": "MATS binds to HPO dimer", "reversible": "false", "notes": "Mps one binder kinase activator-like 1 aka Mob as tumor suppressor protein 1 (MATS) associates with Hippo (HPO) kinase to form a complex.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390158", "map_id": "Q95RA8", "name": "MATS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_390025", "map_id": "none", "name": "Phosphorylated WTS autophosphorylates", "reversible": "false", "notes": "Phosphorylated Warts (WTS) serine/threonine kinase autophosphorylates at unknown residues. WTS linase is now fully activated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390134", "map_id": "none", "name": "Phospho HPO dimer:Phospho SAV:Phospho WTS:Phospho MATS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_390068", "map_id": "none", "name": "Phospho HPO dimer:Phospho SAV:Phospho (2 sites) WTS:Phospho MATS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_390011", "map_id": "none", "name": "HPO dimer binds to SAV", "reversible": "false", "notes": "Hippo (HPO) kinase homodimer associates with the scaffolding protein Salvador (SAV). The C-terminal SARAH (Salvador/Rassf/Hippo) domains of HPO homodimer bind to the N-terminal SARAH domian of SAV.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390185", "map_id": "none", "name": "HPO dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_390014", "map_id": "Q9VCR6", "name": "SAV", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_390154", "map_id": "none", "name": "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS", "reversible": "false", "notes": "Mps one binder kinase activator-like 1 aka Mob as tumor suppressor protein 1 (MATS) is phosphorylated at unknown residues by the activated Hippo (HPO) serine/threonine kinase homodimer. The phosphorylation of MATS by HPO promotes its binding to Warts (WTS) kinase. MATS helps to activate WTS by relieving an autoinhibitory interaction between the N-terminal region and the C-terminal kinase region of WTS. It appears that MATS cannot simultaneously associate with HPO kinase homodimer and WTS in the same protein complex, so MATS dissociates from HPO homodimer and binds to phosphorylated WTS.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10476607", "map_id": "none", "name": "GRB2-1:SOS1 binds p-3Y-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476601", "map_id": "Q9V3C8", "name": "phospho-Shc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10476605", "map_id": "none", "name": "GRB2-1:SOS1:p-3Y-SHC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440940", "map_id": "none", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10440887", "map_id": "Q9V3I5", "name": "JIL-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0020412", "map_id": "FBgn0020412", "name": "JIL-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10440893", "map_id": "Q9V3I5", "name": "phospho-JIL-1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10440935", "map_id": "none", "name": "p-MAPK3/MAPK1/MAPK7 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10440938", "map_id": "none", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10440901", "map_id": "Q9VR61", "name": "S6kII", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10440913", "map_id": "Q9VR61", "name": "phospho-S6kII", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10442249", "map_id": "none", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441236", "map_id": "none", "name": "MAPK3/MAPK1/MAPK7 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10442232", "map_id": "none", "name": "ERK-specific DUSP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "X2JEB8", "map_id": "X2JEB8", "name": "MKP-like", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030976", "map_id": "FBgn0030976", "name": "MKP-like", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVW5", "map_id": "Q9VVW5", "name": "Mkp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036844", "map_id": "FBgn0036844", "name": "Mkp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10442247", "map_id": "none", "name": "VRK3:DUSP3", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10441253", "map_id": "none", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441250", "map_id": "none", "name": "PP2A-ABdeltaC complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8IN89", "map_id": "Q8IN89", "name": "wrd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042693", "map_id": "FBgn0042693", "name": "wrd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440896", "map_id": "none", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437359", "map_id": "none", "name": "p-p38 MAPK alpha/beta", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10441211", "map_id": "none", "name": "RSK1/2/3 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10441226", "map_id": "none", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10441224", "map_id": "none", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441221", "map_id": "P49071", "name": "phospho-MAPk-Ak2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10441219", "map_id": "none", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441213", "map_id": "Q9VWW0", "name": "CrebB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10441216", "map_id": "Q9VWW0", "name": "phospho-CrebB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10440286", "map_id": "none", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192013", "map_id": "CHEBI:18402", "name": "THCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192096", "map_id": "CHEBI:37642", "name": "25(R) THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76577", "map_id": "CHEBI:16027", "name": "AMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440283", "map_id": "none", "name": "Homologues of SLC27A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8SXR7", "map_id": "Q8SXR7", "name": "Fatp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034999", "map_id": "FBgn0034999", "name": "Fatp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KVJ6", "map_id": "Q7KVJ6", "name": "Fatp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265187", "map_id": "FBgn0265187", "name": "Fatp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JHE4", "map_id": "E1JHE4", "name": "Fatp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267828", "map_id": "FBgn0267828", "name": "Fatp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440156", "map_id": "none", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_113535", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192316", "map_id": "CHEBI:37643", "name": "25(S) THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113575", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192342", "map_id": "CHEBI:27505", "name": "THCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10440153", "map_id": "none", "name": "ACOX2:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q9W2G8", "map_id": "Q9W2G8", "name": "Acox57D-d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034629", "map_id": "FBgn0034629", "name": "Acox57D-d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KML2", "map_id": "Q7KML2", "name": "ACOX2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027572", "map_id": "FBgn0027572", "name": "ACOX2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3U0", "map_id": "Q9W3U0", "name": "Dmel\\CG4586", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029924", "map_id": "FBgn0029924", "name": "Dmel\\CG4586", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2G9", "map_id": "Q9W2G9", "name": "Acox57D-p", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034628", "map_id": "FBgn0034628", "name": "Acox57D-p", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440088", "map_id": "none", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192136", "map_id": "CHEBI:17899", "name": "4CHOL7aOLONE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_191980", "map_id": "CHEBI:2290", "name": "5beta-cholestan-7alpha-ol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440119", "map_id": "none", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192030", "map_id": "CHEBI:28047", "name": "5beta-cholestan-3alpha,7alpha-diol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440117", "map_id": "none", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435762", "map_id": "none", "name": "Homologues of SLC27A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10440115", "map_id": "none", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192114", "map_id": "CHEBI:17500", "name": "7 alpha-hydroxycholesterol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10440275", "map_id": "none", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193442", "map_id": "CHEBI:15494", "name": "25(S) DHCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193459", "map_id": "CHEBI:27393", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10440107", "map_id": "none", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192195", "map_id": "CHEBI:28477", "name": "4CHOL7a,12aDONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_192064", "map_id": "CHEBI:2288", "name": "5beta-cholesten-7alpha, 12alpha-diol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440299", "map_id": "none", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141343", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193732", "map_id": "CHEBI:27403", "name": "3,7,24THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10440126", "map_id": "none", "name": "HSD17B4 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q9VXJ0", "map_id": "Q9VXJ0", "name": "Mfe2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030731", "map_id": "FBgn0030731", "name": "Mfe2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440105", "map_id": "none", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192308", "map_id": "CHEBI:37642", "name": "25(R) THCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10440102", "map_id": "Q9VIK0", "name": "Amacr", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "FBgn0032881", "map_id": "FBgn0032881", "name": "Amacr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440297", "map_id": "none", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192307", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193465", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193403", "map_id": "CHEBI:28533", "name": "3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192305", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10440295", "map_id": "none", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193422", "map_id": "CHEBI:52050", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_192339", "map_id": "CHEBI:27379", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10440292", "map_id": "none", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193429", "map_id": "CHEBI:15494", "name": "25(R) DHCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10440290", "map_id": "none", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193505", "map_id": "CHEBI:16577", "name": "DHCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193457", "map_id": "CHEBI:15494", "name": "25(R) DHCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440097", "map_id": "none", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192087", "map_id": "CHEBI:16496", "name": "5beta-cholestan-3alpha,7alpha,12alpha-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440129", "map_id": "none", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10440288", "map_id": "none", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10447126", "map_id": "none", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447104", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Fyn:pCdk5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9V3H5", "map_id": "Q9V3H5", "name": "Cdk5alpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027491", "map_id": "FBgn0027491", "name": "Cdk5alpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48609", "map_id": "P48609", "name": "phospho-Cdk5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013762", "map_id": "FBgn0013762", "name": "phospho-Cdk5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4A7", "map_id": "Q9V4A7", "name": "PlexB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025740", "map_id": "FBgn0025740", "name": "PlexB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V491", "map_id": "Q9V491", "name": "PlexA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025741", "map_id": "FBgn0025741", "name": "PlexA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KK54", "map_id": "Q7KK54", "name": "Sema1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016059", "map_id": "FBgn0016059", "name": "Sema1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24323", "map_id": "Q24323", "name": "Sema2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011260", "map_id": "FBgn0011260", "name": "Sema2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24322", "map_id": "Q24322", "name": "Sema1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011259", "map_id": "FBgn0011259", "name": "Sema1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447082", "map_id": "none", "name": "CRMP's tetramers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IPQ2", "map_id": "Q8IPQ2", "name": "phospho-CRMP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023023", "map_id": "FBgn0023023", "name": "phospho-CRMP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447123", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447158", "map_id": "none", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447155", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10440540", "map_id": "none", "name": "Homologues of GSK3B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P83101", "map_id": "P83101", "name": "gskt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0046332", "map_id": "FBgn0046332", "name": "gskt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18431", "map_id": "P18431", "name": "sgg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "sgg", "map_id": "sgg", "name": "sgg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10447140", "map_id": "none", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447002", "map_id": "none", "name": "Sema3A:NRP-1:pPlexin-A:Fyn:Fes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P18106", "map_id": "P18106", "name": "FER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000723", "map_id": "FBgn0000723", "name": "FER", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447137", "map_id": "none", "name": "Sema3A:NP-1:Plexin-A:Fes:CRMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10442644", "map_id": "P18106", "name": "FER", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10447319", "map_id": "none", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447312", "map_id": "none", "name": "SEMA4D:ERBB2:p-Y-PLXNB1:RND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P04412", "map_id": "P04412", "name": "Egfr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003731", "map_id": "FBgn0003731", "name": "Egfr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10442527", "map_id": "A1ZAN6", "name": "RhoGEF2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0023172", "map_id": "FBgn0023172", "name": "RhoGEF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447314", "map_id": "none", "name": "SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A1ZAN6", "map_id": "A1ZAN6", "name": "RhoGEF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444630", "map_id": "none", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444615", "map_id": "none", "name": "Plexin-B1:ErbB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444599", "map_id": "none", "name": "SEMA4D dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444627", "map_id": "none", "name": "SEMA4D:ERBB2:p-Y-PLXNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447317", "map_id": "none", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447308", "map_id": "none", "name": "RhoA,B,C:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447651", "map_id": "none", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447649", "map_id": "none", "name": "ROCK1,ROCK2:ROCKi", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498524", "map_id": "none", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9686558", "map_id": "none", "name": "ROCKi", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10447670", "map_id": "none", "name": "Dimerization of LIMK1 by Hsp90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441846", "map_id": "P02828", "name": "Hsp83", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10447166", "map_id": "Q8IR79", "name": "phospho-LIMK1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0283712", "map_id": "FBgn0283712", "name": "phospho-LIMK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447660", "map_id": "none", "name": "pLIMK dimer:HSP-90", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IR79", "map_id": "Q8IR79", "name": "phospho-LIMK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10447668", "map_id": "none", "name": "Transphosphorylation of pLIMK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447665", "map_id": "none", "name": "Active LIMK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10447074", "map_id": "none", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447006", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447071", "map_id": "none", "name": "Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447169", "map_id": "none", "name": "Phosphorylation of LIMK-1 by PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447163", "map_id": "Q8IR79", "name": "LIMK1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10447008", "map_id": "none", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447004", "map_id": "none", "name": "Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446511", "map_id": "B7Z0W0", "name": "Pak", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10447047", "map_id": "none", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447041", "map_id": "none", "name": "NRP1:PlexinA1-4:FARP2:FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A8JQT5", "map_id": "A8JQT5", "name": "Cdep", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265082", "map_id": "FBgn0265082", "name": "Cdep", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446972", "map_id": "none", "name": "Sema3A dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10447045", "map_id": "none", "name": "Sema3A:Nrp-1:Plexin A:Fyn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447037", "map_id": "A8JQT5", "name": "Cdep", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10447058", "map_id": "none", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447054", "map_id": "none", "name": "PIP5K1gamma:Talin-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q0E8Y1", "map_id": "Q0E8Y1", "name": "PIP5K59B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034789", "map_id": "FBgn0034789", "name": "PIP5K59B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSL8", "map_id": "Q9VSL8", "name": "rhea", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260442", "map_id": "FBgn0260442", "name": "rhea", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447056", "map_id": "none", "name": "FARP2:PIP5KIgamma", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10444276", "map_id": "Q9VSL8", "name": "rhea", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10449663", "map_id": "none", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449651", "map_id": "none", "name": "Homologues of PLXNC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10449659", "map_id": "none", "name": "Homologues of SEMA7A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10449661", "map_id": "none", "name": "SEMA7A:PLXNC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447402", "map_id": "none", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10447392", "map_id": "none", "name": "Homologues of SEMA3E", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10447398", "map_id": "none", "name": "Homologues of PLXND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447400", "map_id": "none", "name": "SEMA3A:PLXND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447414", "map_id": "none", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447410", "map_id": "none", "name": "Homologues of SEMA4A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447412", "map_id": "none", "name": "SEMA4A:PLXND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447429", "map_id": "none", "name": "SEMA5A binds to PLXNB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447425", "map_id": "none", "name": "Homologues of PLXNB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447419", "map_id": "Q9VTT0", "name": "Sema5c", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0284221", "map_id": "FBgn0284221", "name": "Sema5c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447427", "map_id": "none", "name": "SEMA5A:PLXNB3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VTT0", "map_id": "Q9VTT0", "name": "Sema5c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446800", "map_id": "none", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446797", "map_id": "none", "name": "Grb2:Sos:pFAK bound to NCAM1:pFyn", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q00963", "map_id": "Q00963", "name": "beta-Spec", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250788", "map_id": "FBgn0250788", "name": "beta-Spec", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JNJ6", "map_id": "A8JNJ6", "name": "kst", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004167", "map_id": "FBgn0004167", "name": "kst", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13395", "map_id": "P13395", "name": "alpha-Spec", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250789", "map_id": "FBgn0250789", "name": "alpha-Spec", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR25", "map_id": "Q9VR25", "name": "fipi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031627", "map_id": "FBgn0031627", "name": "fipi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7Z153", "map_id": "B7Z153", "name": "DIP-beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259245", "map_id": "FBgn0259245", "name": "DIP-beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IP70", "map_id": "Q8IP70", "name": "DIP-kappa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051814", "map_id": "FBgn0051814", "name": "DIP-kappa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMN9", "map_id": "Q9VMN9", "name": "DIP-eta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031725", "map_id": "FBgn0031725", "name": "DIP-eta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JNC7", "map_id": "A8JNC7", "name": "DIP-delta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085420", "map_id": "FBgn0085420", "name": "DIP-delta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q59E14", "map_id": "Q59E14", "name": "CT35363", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053543", "map_id": "FBgn0053543", "name": "CT35363", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLF0", "map_id": "Q9VLF0", "name": "DIP-zeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051708", "map_id": "FBgn0051708", "name": "DIP-zeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4R3", "map_id": "Q9W4R3", "name": "DIP-alpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052791", "map_id": "FBgn0052791", "name": "DIP-alpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24372", "map_id": "Q24372", "name": "Lac", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010238", "map_id": "FBgn0010238", "name": "Lac", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAR6", "map_id": "Q9VAR6", "name": "DIP-gamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039617", "map_id": "FBgn0039617", "name": "DIP-gamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444970", "map_id": "none", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_114570", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10444966", "map_id": "none", "name": "Homologues of NCAM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444968", "map_id": "none", "name": "NCAM-1:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10445181", "map_id": "none", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10445177", "map_id": "none", "name": "DSCAM, DSCAML1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VS29", "map_id": "Q9VS29", "name": "Dscam2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265296", "map_id": "FBgn0265296", "name": "Dscam2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VN14", "map_id": "Q9VN14", "name": "Cont", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037240", "map_id": "FBgn0037240", "name": "Cont", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KSE9", "map_id": "Q7KSE9", "name": "Dscam3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261046", "map_id": "FBgn0261046", "name": "Dscam3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445179", "map_id": "none", "name": "DSCAM/DSCAML1 homodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10445193", "map_id": "none", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445189", "map_id": "none", "name": "p-S144-PAK1:RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10445167", "map_id": "none", "name": "Homologues of DSCAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10445191", "map_id": "none", "name": "DSCAM:p-S144-PAK1:RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10451543", "map_id": "none", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437423", "map_id": "P92208", "name": "bsk", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10437429", "map_id": "P92208", "name": "phospho-bsk", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10451574", "map_id": "none", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10444747", "map_id": "none", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444743", "map_id": "P46150", "name": "Moe", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0011661", "map_id": "FBgn0011661", "name": "Moe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444745", "map_id": "none", "name": "EZR:PIP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P46150", "map_id": "P46150", "name": "Moe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444759", "map_id": "none", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444752", "map_id": "none", "name": "p-T567-EZR:PIP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10441896", "map_id": "P83099", "name": "phospho-Pkcdelta", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10444447", "map_id": "none", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444421", "map_id": "none", "name": "Homologues of DCC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A1Z920", "map_id": "A1Z920", "name": "phospho-fra", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011592", "map_id": "FBgn0011592", "name": "phospho-fra", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O97394", "map_id": "O97394", "name": "phospho-sdk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0021764", "map_id": "FBgn0021764", "name": "phospho-sdk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444443", "map_id": "none", "name": "DCC:NTN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q24567", "map_id": "Q24567", "name": "NetA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015773", "map_id": "FBgn0015773", "name": "NetA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444445", "map_id": "none", "name": "NTN1:DCC oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444795", "map_id": "none", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444792", "map_id": "none", "name": "NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444508", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444449", "map_id": "none", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10444441", "map_id": "Q24567", "name": "NetA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10444512", "map_id": "none", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444486", "map_id": "Q9VPU1", "name": "dock", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444510", "map_id": "none", "name": "NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453702", "map_id": "none", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10453698", "map_id": "none", "name": "DCC, UNC5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95TU8", "map_id": "Q95TU8", "name": "unc-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034013", "map_id": "FBgn0034013", "name": "unc-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10453691", "map_id": "P11046", "name": "LanB1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0261800", "map_id": "FBgn0261800", "name": "LanB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10453700", "map_id": "none", "name": "NTN4:DCC,UNC5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P11046", "map_id": "P11046", "name": "LanB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444756", "map_id": "none", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444754", "map_id": "none", "name": "DCC:p-T567-EZR:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444786", "map_id": "none", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444782", "map_id": "none", "name": "Homologues of SIAH2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W4W4", "map_id": "Q9W4W4", "name": "Dmel\\CG2681", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024997", "map_id": "FBgn0024997", "name": "Dmel\\CG2681", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T3Y0", "map_id": "Q8T3Y0", "name": "sinah", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259794", "map_id": "FBgn0259794", "name": "sinah", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P21461", "map_id": "P21461", "name": "sina", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003410", "map_id": "FBgn0003410", "name": "sina", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444784", "map_id": "none", "name": "NTN1:DCC:SIAH2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444768", "map_id": "none", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444764", "map_id": "P21461", "name": "sina", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444766", "map_id": "none", "name": "NTN1:DCC:SIAH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496097", "map_id": "none", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10496093", "map_id": "none", "name": "SLIT2,(SLIT3)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VUN0", "map_id": "Q9VUN0", "name": "Toll-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036494", "map_id": "FBgn0036494", "name": "Toll-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P24014", "map_id": "P24014", "name": "sli", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "sli", "map_id": "sli", "name": "sli", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2299699", "map_id": "CHEBI:60924", "name": "Keratan sulfate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10496095", "map_id": "none", "name": "SLIT2,(SLIT3):Keratan sulfate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10448744", "map_id": "none", "name": "Phosphorylation of ROBO1 by ABL kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445201", "map_id": "none", "name": "SLIT2:ROBO1:ABL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P00522", "map_id": "P00522", "name": "Abl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Abl", "map_id": "Abl", "name": "Abl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PC46", "map_id": "M9PC46", "name": "phospho-robo2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002543", "map_id": "FBgn0002543", "name": "phospho-robo2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W213", "map_id": "Q9W213", "name": "phospho-robo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005631", "map_id": "FBgn0005631", "name": "phospho-robo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10448741", "map_id": "none", "name": "SLIT2:p-Y1073-ROBO1:ABL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10445203", "map_id": "none", "name": "Interaction of ABL with ROBO1:SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442417", "map_id": "none", "name": "ROBO1:SLIT2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10445197", "map_id": "P00522", "name": "Abl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10448598", "map_id": "none", "name": "Glypican-1 (GPC1) binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448594", "map_id": "none", "name": "GPC1:HSPG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VUG1", "map_id": "Q9VUG1", "name": "dlp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041604", "map_id": "FBgn0041604", "name": "dlp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17421", "map_id": "CHEBI:17421", "name": "CHEBI:17421", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10448587", "map_id": "none", "name": "SLIT2,SLIT2 cleavage fragments", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10448596", "map_id": "none", "name": "SLIT2,SLIT2 cleavage fragments:GPC1:HSPG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496540", "map_id": "none", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10496536", "map_id": "none", "name": "ROBO1,ROBO2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A8JUV7", "map_id": "A8JUV7", "name": "boi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040388", "map_id": "FBgn0040388", "name": "boi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM64", "map_id": "Q9VM64", "name": "ihog", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ihog", "map_id": "ihog", "name": "ihog", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496538", "map_id": "none", "name": "ROBO1,ROBO2:Keratan sulfate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10442419", "map_id": "none", "name": "ROBO1 binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442404", "map_id": "none", "name": "Homologues of ROBO1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10442415", "map_id": "none", "name": "Homologues of SLIT2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10448585", "map_id": "none", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448581", "map_id": "none", "name": "ROBO2,(ROBO1)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10448573", "map_id": "none", "name": "Homologues of ROBO3.1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10448583", "map_id": "none", "name": "ROBO2,(ROBO1):ROBO3.1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469295", "map_id": "none", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469291", "map_id": "none", "name": "EPH-EFN dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9V4E5", "map_id": "Q9V4E5", "name": "Eph", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025936", "map_id": "FBgn0025936", "name": "Eph", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4E1", "map_id": "Q9V4E1", "name": "phospho-Ephrin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040324", "map_id": "FBgn0040324", "name": "phospho-Ephrin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469293", "map_id": "none", "name": "EPHAs:EFNAs,EPHBs:EFNBs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469226", "map_id": "none", "name": "EPH-ephrin oligomers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469436", "map_id": "none", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469389", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A8DZ19", "map_id": "A8DZ19", "name": "RtGEF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015803", "map_id": "FBgn0015803", "name": "RtGEF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95RG8", "map_id": "Q95RG8", "name": "Git", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033539", "map_id": "FBgn0033539", "name": "Git", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469391", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469434", "map_id": "none", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450286", "map_id": "P40423", "name": "sqh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10450386", "map_id": "P40423", "name": "phospho-sqh", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469397", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469641", "map_id": "none", "name": "EFNBs bind SDCBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469222", "map_id": "none", "name": "EPHBs:EFNBs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444571", "map_id": "A8JQY9", "name": "CG7472", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0051342", "map_id": "FBgn0051342", "name": "CG7472", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469639", "map_id": "none", "name": "EPHBs:EFNBs:SDCBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A8JQY9", "map_id": "A8JQY9", "name": "CG7472", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469368", "map_id": "none", "name": "EFNBs bind SFKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444516", "map_id": "P00528", "name": "Src64B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469366", "map_id": "none", "name": "EPHBs:EFNBs:SRC,FYN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469400", "map_id": "none", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10469431", "map_id": "none", "name": "p-EFNB binds GRB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444514", "map_id": "Q9VPU1", "name": "dock", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469352", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469354", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469429", "map_id": "none", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442464", "map_id": "none", "name": "RAC1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469387", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_114549", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10469364", "map_id": "none", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469360", "map_id": "Q95RG8", "name": "phospho-Git", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469362", "map_id": "none", "name": "EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469426", "map_id": "none", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439144", "map_id": "A8DZ19", "name": "RtGEF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10469457", "map_id": "none", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10434904", "map_id": "none", "name": "RHOA:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469454", "map_id": "none", "name": "EFNAs:p-EPHAs:SFKs:p-Y179-NGEF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VVC6", "map_id": "Q9VVC6", "name": "Exn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261547", "map_id": "FBgn0261547", "name": "Exn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469385", "map_id": "none", "name": "EPHBs bind EFNBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469206", "map_id": "Q9V4E1", "name": "Ephrin", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10469212", "map_id": "Q9V4E5", "name": "Eph", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10469320", "map_id": "none", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10469447", "map_id": "none", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469184", "map_id": "Q9V4E5", "name": "Eph", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10469171", "map_id": "Q9V4E1", "name": "Ephrin", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10469202", "map_id": "none", "name": "EPHAs:EFNAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469285", "map_id": "none", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469282", "map_id": "none", "name": "p-EPH:ephrin oligomers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469657", "map_id": "none", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428485", "map_id": "none", "name": "Rac1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10469418", "map_id": "none", "name": "EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91621", "map_id": "P91621", "name": "sif", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085447", "map_id": "FBgn0085447", "name": "sif", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24418", "map_id": "Q24418", "name": "Nmdar1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010399", "map_id": "FBgn0010399", "name": "Nmdar1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W581", "map_id": "Q9W581", "name": "phospho-Nmdar2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053513", "map_id": "FBgn0053513", "name": "phospho-Nmdar2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29424", "map_id": "CHEBI:57305", "name": "Gly", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_210382", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10469304", "map_id": "none", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469301", "map_id": "none", "name": "EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9PBE1", "map_id": "M9PBE1", "name": "cyst", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032796", "map_id": "FBgn0032796", "name": "cyst", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469654", "map_id": "none", "name": "p-EPHB phosphorylates SDC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461274", "map_id": "P49415", "name": "Sdc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0010415", "map_id": "FBgn0010415", "name": "phospho-Sdc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469651", "map_id": "P49415", "name": "phospho-Sdc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10469280", "map_id": "none", "name": "p-EPHB:EFNB oligomers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469647", "map_id": "none", "name": "Ras:GTP binds p120-RasGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206703", "map_id": "none", "name": "RAS85D:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469643", "map_id": "none", "name": "p-EPHBs:EFNBs:RASA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469645", "map_id": "none", "name": "p-EPHBs:EFNBs:RASA1:HRAS:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469166", "map_id": "none", "name": "RHOA:GTP binds ROCK, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10469421", "map_id": "none", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469413", "map_id": "none", "name": "EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469322", "map_id": "none", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469312", "map_id": "none", "name": "p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9ND00", "map_id": "M9ND00", "name": "Dap160", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023388", "map_id": "FBgn0023388", "name": "Dap160", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469314", "map_id": "none", "name": "p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469383", "map_id": "none", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469374", "map_id": "none", "name": "RAC1:GTP:PAK1 dimer:RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469380", "map_id": "none", "name": "RAC1-GTP:p-S144,T423-PAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469318", "map_id": "none", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461790", "map_id": "none", "name": "ARP2/3 complex (ATP bound)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VIM5", "map_id": "Q9VIM5", "name": "Arpc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032859", "map_id": "FBgn0032859", "name": "Arpc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQD8", "map_id": "Q9VQD8", "name": "Arpc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031437", "map_id": "FBgn0031437", "name": "Arpc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O97182", "map_id": "O97182", "name": "Arpc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001961", "map_id": "FBgn0001961", "name": "Arpc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P45888", "map_id": "P45888", "name": "Arp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011742", "map_id": "FBgn0011742", "name": "Arp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMH2", "map_id": "Q9VMH2", "name": "Arpc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284255", "map_id": "FBgn0284255", "name": "Arpc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32392", "map_id": "P32392", "name": "Arp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262716", "map_id": "FBgn0262716", "name": "Arp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VF28", "map_id": "Q9VF28", "name": "Arpc3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038369", "map_id": "FBgn0038369", "name": "Arpc3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10442127", "map_id": "none", "name": "G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10469316", "map_id": "none", "name": "p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469445", "map_id": "none", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442480", "map_id": "P91621", "name": "sif", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469411", "map_id": "none", "name": "EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469668", "map_id": "none", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469666", "map_id": "none", "name": "p-Y179,Y191-SDC2 cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P49415", "map_id": "P49415", "name": "phospho-Sdc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469376", "map_id": "none", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10446513", "map_id": "none", "name": "PAK1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10442466", "map_id": "none", "name": "RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469664", "map_id": "none", "name": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469661", "map_id": "none", "name": "p-EPHBs:EFNBs:RASA1:HRAS:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469503", "map_id": "none", "name": "gamma-secretase cleaves EPHB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469481", "map_id": "Q9V4E5", "name": "Eph", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10469491", "map_id": "Q9V4E5", "name": "Eph", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469501", "map_id": "Q9V4E5", "name": "Eph", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10458502", "map_id": "none", "name": "gamma-secretase complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VQG2", "map_id": "Q9VQG2", "name": "aph-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031458", "map_id": "FBgn0031458", "name": "aph-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86BE9", "map_id": "Q86BE9", "name": "pen-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053198", "map_id": "FBgn0053198", "name": "pen-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O02194", "map_id": "O02194", "name": "Psn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284421", "map_id": "FBgn0284421", "name": "Psn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VC27", "map_id": "Q9VC27", "name": "Nct", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039234", "map_id": "FBgn0039234", "name": "Nct", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469516", "map_id": "none", "name": "MMP2,9 cleave EPHB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469505", "map_id": "Q9V4E5", "name": "Eph", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10459272", "map_id": "Q9W122", "name": "Mmp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "FBgn0035049", "map_id": "FBgn0035049", "name": "Mmp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469479", "map_id": "none", "name": "Clathrin internalises EPH:EFN complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469475", "map_id": "none", "name": "AP-2 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O62530", "map_id": "O62530", "name": "AP-2mu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263351", "map_id": "FBgn0263351", "name": "AP-2mu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24253", "map_id": "Q24253", "name": "AP-1-2beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010380", "map_id": "FBgn0010380", "name": "AP-1-2beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91926", "map_id": "P91926", "name": "AP-2alpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264855", "map_id": "FBgn0264855", "name": "AP-2alpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDC3", "map_id": "Q9VDC3", "name": "AP-2sigma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0043012", "map_id": "FBgn0043012", "name": "AP-2sigma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10439846", "map_id": "P27619", "name": "shi", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0003392", "map_id": "FBgn0003392", "name": "shi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469463", "map_id": "none", "name": "f-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439790", "map_id": "none", "name": "Clathrin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10469477", "map_id": "none", "name": "EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P27619", "map_id": "P27619", "name": "shi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469333", "map_id": "none", "name": "p-EPHs bind VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442473", "map_id": "Q9NHV9", "name": "Vav", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469324", "map_id": "none", "name": "p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469326", "map_id": "none", "name": "EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469637", "map_id": "none", "name": "EPHA binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469438", "map_id": "none", "name": "EFNAs:p-EPHAs:SFKs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469440", "map_id": "none", "name": "EFNAs:p-EPHAs:SFKs:TIAM1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469331", "map_id": "none", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469328", "map_id": "none", "name": "EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469443", "map_id": "none", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10450221", "map_id": "none", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446836", "map_id": "none", "name": "L1:AP-2 Clathrin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "P29742", "map_id": "P29742", "name": "Chc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000319", "map_id": "FBgn0000319", "name": "Chc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWA1", "map_id": "Q9VWA1", "name": "Clc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024814", "map_id": "FBgn0024814", "name": "Clc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T390", "map_id": "Q8T390", "name": "EndoA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038659", "map_id": "FBgn0038659", "name": "EndoA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10433787", "map_id": "P40417", "name": "phospho-rl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10450218", "map_id": "none", "name": "pL1 (S1204, 1248):ERK2:clathrin-dynamin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17940", "compartment_display": "endosome", "complex": "true" }, { "id": "reaction_10453467", "map_id": "none", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10438817", "map_id": "Q8T390", "name": "EndoA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10453462", "map_id": "none", "name": "L1:clathrin-coated vesicle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439850", "map_id": "none", "name": "Dynamin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10446838", "map_id": "none", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "reaction_10444575", "map_id": "none", "name": "Neurofascin interacts with syntenin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444543", "map_id": "none", "name": "Homologues of NFASC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444573", "map_id": "none", "name": "Neurofascin:Syntenin-1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444553", "map_id": "none", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444549", "map_id": "none", "name": "Homologues of NRCAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444551", "map_id": "none", "name": "NFASC:NRCAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449908", "map_id": "none", "name": "Trans-homodimerization of Neurofascin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449904", "map_id": "none", "name": "Neurofascin:Ankyrin-G complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q0KIE7", "map_id": "Q0KIE7", "name": "Ank", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011747", "map_id": "FBgn0011747", "name": "Ank", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449906", "map_id": "none", "name": "Trans neurofascin dimer:ankyrin-G", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450094", "map_id": "none", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449774", "map_id": "Q9NHV9", "name": "phospho-Vav", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10450214", "map_id": "none", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450211", "map_id": "none", "name": "pPAK1:Rac1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10433782", "map_id": "none", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433757", "map_id": "none", "name": "p-2S-MAP2K1:MAPK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q24324", "map_id": "Q24324", "name": "phospho-Dsor1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-Dsor1", "map_id": "phospho-Dsor1", "name": "phospho-Dsor1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10433773", "map_id": "none", "name": "p-T,Y-MAPK3:p-2S-MAP2K1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433778", "map_id": "Q24324", "name": "phospho-Dsor1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433792", "map_id": "none", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433765", "map_id": "none", "name": "p-S,T-MAP2K2:MAPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433789", "map_id": "none", "name": "p-S,T-MAP2K2:p-T,Y-MAPK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497559", "map_id": "none", "name": "Autocleavage of ADGRG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10497538", "map_id": "none", "name": "Homologues of ADGRG6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VA10", "map_id": "Q9VA10", "name": "anon-WO0170980.178", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039821", "map_id": "FBgn0039821", "name": "anon-WO0170980.178", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7G7", "map_id": "A1Z7G7", "name": "Cirl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033313", "map_id": "FBgn0033313", "name": "Cirl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SZ78", "map_id": "Q8SZ78", "name": "anon-WO0170980.121", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039818", "map_id": "FBgn0039818", "name": "anon-WO0170980.121", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497556", "map_id": "none", "name": "ADGRG6-CTF:ADGRG6-NTF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10497561", "map_id": "none", "name": "ADGRG heterodimer translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10437846", "map_id": "none", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437831", "map_id": "O62609", "name": "Med", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0011655", "map_id": "FBgn0011655", "name": "Med", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437838", "map_id": "O96660", "name": "phospho-Smox", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0025800", "map_id": "FBgn0025800", "name": "phospho-Smox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437844", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O96660", "map_id": "O96660", "name": "phospho-Smox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62609", "map_id": "O62609", "name": "Med", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10437955", "map_id": "none", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437946", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10459921", "map_id": "none", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_1535904", "map_id": "none", "name": "FoxO3a-binding Element", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10441099", "map_id": "Q95V55", "name": "foxo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10459919", "map_id": "none", "name": "SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95V55", "map_id": "Q95V55", "name": "foxo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "foxo", "map_id": "foxo", "name": "foxo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10443101", "map_id": "none", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441097", "map_id": "Q95V55", "name": "foxo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10441108", "map_id": "Q95V55", "name": "phospho-foxo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10441086", "map_id": "Q8INB9", "name": "phospho-Akt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10443105", "map_id": "none", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10443103", "map_id": "Q95V55", "name": "phospho-foxo", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10486931", "map_id": "none", "name": "Envoplakin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486927", "map_id": "A1Z9J3", "name": "shot", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0013733", "map_id": "FBgn0013733", "name": "shot", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486925", "map_id": "A1Z9J3", "name": "shot", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486929", "map_id": "none", "name": "EVPL:PPL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1Z9J3", "map_id": "A1Z9J3", "name": "shot", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10480300", "map_id": "none", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_171126", "map_id": "CHEBI:17855", "name": "TAGs", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_174675", "map_id": "CHEBI:18035", "name": "DAGs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_6789319", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10480297", "map_id": "none", "name": "keratinocyte LIPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VPE9", "map_id": "Q9VPE9", "name": "mag", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036996", "map_id": "FBgn0036996", "name": "mag", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG47", "map_id": "Q9VG47", "name": "Dmel\\CG11608", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038069", "map_id": "FBgn0038069", "name": "Dmel\\CG11608", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG46", "map_id": "Q9VG46", "name": "Dmel\\CG6753", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038070", "map_id": "FBgn0038070", "name": "Dmel\\CG6753", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBK6", "map_id": "Q9VBK6", "name": "CG5990", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051091", "map_id": "FBgn0051091", "name": "CG5990", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9N3", "map_id": "Q9V9N3", "name": "Dmel\\CG3635", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032981", "map_id": "FBgn0032981", "name": "Dmel\\CG3635", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IMS3", "map_id": "Q8IMS3", "name": "CG5990", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q59E63", "map_id": "Q59E63", "name": "Dmel\\CG11406", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034990", "map_id": "FBgn0034990", "name": "Dmel\\CG11406", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQQ5", "map_id": "Q9VQQ5", "name": "Dmel\\CG2772", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031533", "map_id": "FBgn0031533", "name": "Dmel\\CG2772", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V6L4", "map_id": "Q4V6L4", "name": "Dmel\\CG8093", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033999", "map_id": "FBgn0033999", "name": "Dmel\\CG8093", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0KI77", "map_id": "Q0KI77", "name": "Dmel\\CG11598", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038067", "map_id": "FBgn0038067", "name": "Dmel\\CG11598", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKT8", "map_id": "Q9VKT8", "name": "Dmel\\CG18301", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032265", "map_id": "FBgn0032265", "name": "Dmel\\CG18301", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46108", "map_id": "O46108", "name": "Lip3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023495", "map_id": "FBgn0023495", "name": "Lip3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKT7", "map_id": "Q9VKT7", "name": "Dmel\\CG18302", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032266", "map_id": "FBgn0032266", "name": "Dmel\\CG18302", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46107", "map_id": "O46107", "name": "Lip1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023496", "map_id": "FBgn0023496", "name": "Lip1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKT2", "map_id": "Q9VKT2", "name": "Dmel\\CG7329", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032271", "map_id": "FBgn0032271", "name": "Dmel\\CG7329", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PCU5", "map_id": "M9PCU5", "name": "Lip4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032264", "map_id": "FBgn0032264", "name": "Lip4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKT1", "map_id": "Q9VKT1", "name": "CG17093", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051872", "map_id": "FBgn0051872", "name": "CG17093", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E2QCS7", "map_id": "E2QCS7", "name": "Dmel\\CG17097", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265264", "map_id": "FBgn0265264", "name": "Dmel\\CG17097", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKS9", "map_id": "Q9VKS9", "name": "Acp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0043825", "map_id": "FBgn0043825", "name": "Acp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKS5", "map_id": "Q9VKS5", "name": "CG17099", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051871", "map_id": "FBgn0051871", "name": "CG17099", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKR5", "map_id": "Q9VKR5", "name": "Lip2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024740", "map_id": "FBgn0024740", "name": "Lip2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG50", "map_id": "Q9VG50", "name": "CG12294", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042207", "map_id": "FBgn0042207", "name": "CG12294", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG48", "map_id": "Q9VG48", "name": "Dmel\\CG11600", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038068", "map_id": "FBgn0038068", "name": "Dmel\\CG11600", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487309", "map_id": "none", "name": "EVL:PPL heterodimer binds the inner surface of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_983438", "map_id": "none", "name": "Cell surface", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10486933", "map_id": "none", "name": "EVPL:PPL:Cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10487326", "map_id": "none", "name": "Kazrin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487322", "map_id": "A8DYM0", "name": "Liprin-gamma", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0034720", "map_id": "FBgn0034720", "name": "Liprin-gamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487324", "map_id": "none", "name": "KAZN:PPL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A8DYM0", "map_id": "A8DYM0", "name": "Liprin-gamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444879", "map_id": "none", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444869", "map_id": "none", "name": "Homologues of BOC-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444875", "map_id": "none", "name": "Homologues of CDON", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444877", "map_id": "none", "name": "CDO:BOC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450726", "map_id": "none", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10450724", "map_id": "none", "name": "pp38 alpha/beta/gamma:ABL1:JLP:CDO complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VZJ4", "map_id": "Q9VZJ4", "name": "anon-EST:Posey64", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035488", "map_id": "FBgn0035488", "name": "anon-EST:Posey64", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GQF1", "map_id": "Q9GQF1", "name": "syd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024187", "map_id": "FBgn0024187", "name": "syd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450672", "map_id": "none", "name": "phospho-p38 alpha/beta/gamma MAPK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10450722", "map_id": "none", "name": "ABL1:JLP:CDO complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450755", "map_id": "none", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10450683", "map_id": "none", "name": "phospho-MEF2 proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P40791", "map_id": "P40791", "name": "phospho-Mef2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011656", "map_id": "FBgn0011656", "name": "phospho-Mef2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450751", "map_id": "none", "name": "Myod:phospho-E heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P11420", "map_id": "P11420", "name": "da", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267821", "map_id": "FBgn0267821", "name": "da", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22816", "map_id": "P22816", "name": "nau", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002922", "map_id": "FBgn0002922", "name": "nau", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450753", "map_id": "none", "name": "MyoD:phospho-E:phospho MEF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10444914", "map_id": "none", "name": "CDO binds promyogenic cadherins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444910", "map_id": "none", "name": "Trans-cadherin homodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444912", "map_id": "none", "name": "CDO:BOC:Trans-cadherin homodimer:catenin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450688", "map_id": "none", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10450656", "map_id": "P40791", "name": "Mef2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10450685", "map_id": "none", "name": "phospho p38:phospho MEF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10445986", "map_id": "none", "name": "Formation of PPARG:RXRA heterodimer (ARF6 complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10440428", "map_id": "P20153", "name": "usp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0003964", "map_id": "FBgn0003964", "name": "usp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445293", "map_id": "P13055", "name": "Eip75B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0000568", "map_id": "FBgn0000568", "name": "Eip75B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445984", "map_id": "none", "name": "PPARG:RXRA Heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P13055", "map_id": "P13055", "name": "Eip75B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20153", "map_id": "P20153", "name": "usp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497719", "map_id": "none", "name": "CEBPA binds CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432391", "map_id": "Q7K306", "name": "Cdk4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0016131", "map_id": "FBgn0016131", "name": "Cdk4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497715", "map_id": "none", "name": "Homologues of CEBPA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VK13", "map_id": "Q9VK13", "name": "Mabi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032493", "map_id": "FBgn0032493", "name": "Mabi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02637", "map_id": "Q02637", "name": "slbo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005638", "map_id": "FBgn0005638", "name": "slbo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497717", "map_id": "none", "name": "CEBPA:CDK4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7K306", "map_id": "Q7K306", "name": "Cdk4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497723", "map_id": "none", "name": "CEBPA binds CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427334", "map_id": "P23573", "name": "Cdk2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10497721", "map_id": "none", "name": "CEBPA:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497614", "map_id": "none", "name": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497606", "map_id": "none", "name": "CEBPE gene:RARA:RXRA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5334804", "map_id": "CHEBI:15367", "name": "atRA", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10497612", "map_id": "none", "name": "CEBPE gene:RXRA:RARA:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5334816", "map_id": "CHEBI:15367", "name": "atRA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10430843", "map_id": "none", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430839", "map_id": "none", "name": "40S:eIF3:eIF1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VEA1", "map_id": "Q9VEA1", "name": "eIF1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026250", "map_id": "FBgn0026250", "name": "eIF1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U9Q4", "map_id": "Q9U9Q4", "name": "eIF3h", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022023", "map_id": "FBgn0022023", "name": "eIF3h", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTU4", "map_id": "Q9VTU4", "name": "eIF3l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036258", "map_id": "FBgn0036258", "name": "eIF3l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E940", "map_id": "Q0E940", "name": "eIF3b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034237", "map_id": "FBgn0034237", "name": "eIF3b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2D9", "map_id": "Q9W2D9", "name": "eIF3k", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034654", "map_id": "FBgn0034654", "name": "eIF3k", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VN50", "map_id": "Q9VN50", "name": "eIF3f1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037270", "map_id": "FBgn0037270", "name": "eIF3f1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O77410", "map_id": "O77410", "name": "eIF3e", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025582", "map_id": "FBgn0025582", "name": "eIF3e", "type": 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9020583", "map_id": "CHEBI:138387", "name": "18(S)-HpEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29450", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9020474", "map_id": "CHEBI:132801", "name": "18(S)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111745", "map_id": "CHEBI:17858", "name": "GSSG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10496831", "map_id": "Q8IRD3", "name": "PHGPx", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035438", "map_id": "FBgn0035438", "name": "PHGPx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496829", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9022655", "map_id": "CHEBI:138490", "name": "5S,6S-epoxy-18(S)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9022660", "map_id": "CHEBI:137038", "name": "18(S)-RvE1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10443840", "map_id": "none", "name": "LTA4H:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VJ39", "map_id": "Q9VJ39", "name": "pepCG10602", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032721", "map_id": "FBgn0032721", "name": "pepCG10602", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496973", "map_id": "none", "name": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023963", "map_id": "CHEBI:131617", "name": "18-oxo-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10496836", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023708", "map_id": "CHEBI:138563", "name": "5S,6S-epoxy-18(R)-HEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023712", "map_id": "CHEBI:81559", "name": "18(R)-RvE1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10496838", "map_id": "none", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9023653", "map_id": "CHEBI:138565", "name": "18(R)-HpEPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9023651", "map_id": "CHEBI:81563", "name": "18(R)-HEPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10496848", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024577", "map_id": "CHEBI:138612", "name": "4S(5)-epoxy-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024570", "map_id": "none", "name": "AT-RvD3, AT-RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138615", "map_id": "CHEBI:138615", "name": "CHEBI:138615", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138616", "map_id": "CHEBI:138616", "name": "CHEBI:138616", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496850", "map_id": "none", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024522", "map_id": "CHEBI:138590", "name": "17(R)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024463", "map_id": "CHEBI:91137", "name": "17(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10496840", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024602", "map_id": "CHEBI:138613", "name": "7S(8)-epoxy-17(R)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024574", "map_id": "none", "name": "AT-RvD1, AT-RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138179", "map_id": "CHEBI:138179", "name": "CHEBI:138179", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138614", "map_id": "CHEBI:138614", "name": "CHEBI:138614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497011", "map_id": "none", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024011", "map_id": "CHEBI:28125", "name": "DHA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9027049", "map_id": "CHEBI:137346", "name": "14(R)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10432773", "map_id": "none", "name": "Homologues of CYP2D6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q95078", "map_id": "Q95078", "name": "Cyp18a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010383", "map_id": "FBgn0010383", "name": "Cyp18a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWR5", "map_id": "Q9VWR5", "name": "phm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004959", "map_id": "FBgn0004959", "name": "phm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496852", "map_id": "none", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024012", "map_id": "CHEBI:136113", "name": "17(S)-Hp-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024815", "map_id": "CHEBI:138640", "name": "17(S)-HDHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10496842", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024781", "map_id": "CHEBI:138647", "name": "4S(5)-epoxy-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024809", "map_id": "none", "name": "RvD3, RvD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:138649", "map_id": "CHEBI:138649", "name": "CHEBI:138649", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:138648", "map_id": "CHEBI:138648", "name": "CHEBI:138648", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497004", "map_id": "none", "name": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024764", "map_id": "CHEBI:81564", "name": "RvD1", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_9024799", "map_id": "none", "name": "17(S)-oxo-RvD1, 8-oxo-17(S)-RvD1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:132797", "map_id": "CHEBI:132797", "name": "CHEBI:132797", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:132800", "map_id": "CHEBI:132800", "name": "CHEBI:132800", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496846", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024768", "map_id": "CHEBI:138646", "name": "7S(8)-epoxy-17(S)-HDHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024759", "map_id": "none", "name": "RvD1, RvD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:81565", "map_id": "CHEBI:81565", "name": "CHEBI:81565", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496844", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024893", "map_id": "CHEBI:140192", "name": "17R(16)-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024879", "map_id": "CHEBI:140202", "name": "AT-(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10497006", "map_id": "none", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9024873", "map_id": "CHEBI:140225", "name": "16S,17S-epoxy-DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_9024886", "map_id": "CHEBI:138655", "name": "(N)PD1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10450926", "map_id": "none", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437365", "map_id": "P92208", "name": "phospho-bsk", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10437443", "map_id": "none", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437440", "map_id": "O61444", "name": "phospho-Mkk4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0024326", "map_id": "FBgn0024326", "name": "phospho-Mkk4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450893", "map_id": "none", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450883", "map_id": "O62602", "name": "phospho-lic", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0261524", "map_id": "FBgn0261524", "name": "phospho-lic", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450889", "map_id": "O62602", "name": "phospho-lic", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10450918", "map_id": "none", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10450915", "map_id": "none", "name": "p38 MAPK:MAPKAPK2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P49071", "map_id": "P49071", "name": "phospho-MAPk-Ak2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450840", "map_id": "none", "name": "p-p38 MAPK: MAPKAPK2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10450853", "map_id": "none", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450846", "map_id": "none", "name": "p-p38 MAPK:p-MAPKAPK2/3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10450851", "map_id": "none", "name": "p-p38 MAPK: p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10450849", "map_id": "none", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10450876", "map_id": "none", "name": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10450872", "map_id": "none", "name": "Homologues of p-T325,T331,S362,S374-FOS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XZS8", "map_id": "Q9XZS8", "name": "phospho-Atf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028550", "map_id": "FBgn0028550", "name": "phospho-Atf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437390", "map_id": "P18289", "name": "phospho-Jra", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10450874", "map_id": "none", "name": "p-2S-cJUN:p-2S,2T-cFOS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437382", "map_id": "none", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437328", "map_id": "Q2PE13", "name": "Atf-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0265193", "map_id": "FBgn0265193", "name": "Atf-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437332", "map_id": "Q2PE13", "name": "phospho-Atf-2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10437379", "map_id": "none", "name": "Activated MAPK kinases ERK1/2, JNK, p38", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10450901", "map_id": "none", "name": "c-FOS activation by phospho ERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10450899", "map_id": "none", "name": "Homologues of FOS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437461", "map_id": "none", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437459", "map_id": "none", "name": "p-2S-cJUN:p-2T-ATF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q2PE13", "map_id": "Q2PE13", "name": "Atf-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10437393", "map_id": "none", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437386", "map_id": "P18289", "name": "Jra", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10463567", "map_id": "none", "name": "EXT1:EXT2 transfer GlcNAc to the heparan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10463526", "map_id": "none", "name": "Heparan(1)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q24114", "map_id": "Q24114", "name": "dally", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "dally", "map_id": "dally", "name": "dally", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10463552", "map_id": "none", "name": "Heparan(2)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10463564", "map_id": "none", "name": "EXT1:EXT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9Y169", "map_id": "Q9Y169", "name": "sotv", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029175", "map_id": "FBgn0029175", "name": "sotv", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V730", "map_id": "Q9V730", "name": "ttv", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265974", "map_id": "FBgn0265974", "name": "ttv", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10463662", "map_id": "none", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10463622", "map_id": "none", "name": "Heparan(4)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10463648", "map_id": "none", "name": "HS(1)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10463653", "map_id": "Q9V3L1", "name": "sfl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0020251", "map_id": "FBgn0020251", "name": "sfl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464814", "map_id": "none", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10463809", "map_id": "none", "name": "HS(5)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10463831", "map_id": "none", "name": "HS/HPIN-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10464807", "map_id": "Q9VDR6", "name": "Hs6st", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0038755", "map_id": "FBgn0038755", "name": "Hs6st", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10463596", "map_id": "none", "name": "EXT1:EXT2 transfers GlcNAc to heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1889970", "map_id": "CHEBI:17200", "name": "UDP-GlcA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10463593", "map_id": "none", "name": "Heparan-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10463691", "map_id": "none", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_2022884", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10463688", "map_id": "none", "name": "Heparan(3)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_2022890", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10463947", "map_id": "none", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10463833", "map_id": "none", "name": "HSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10463945", "map_id": "none", "name": "HSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10464822", "map_id": "none", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10463731", "map_id": "none", "name": "HS(2)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10463757", "map_id": "none", "name": "HS(3)-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10464819", "map_id": "P25722", "name": "Hs2st", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0024230", "map_id": "FBgn0024230", "name": "Hs2st", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464836", "map_id": "none", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10463783", "map_id": "none", "name": "HS(4)-PGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10464833", "map_id": "none", "name": "HS3STs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q8MRE7", "map_id": "Q8MRE7", "name": "Hs3st-A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053147", "map_id": "FBgn0053147", "name": "Hs3st-A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWJ7", "map_id": "Q9VWJ7", "name": "Hs3st-B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031005", "map_id": "FBgn0031005", "name": "Hs3st-B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10463699", "map_id": "none", "name": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10463697", "map_id": "none", "name": "GlcA-Gal-Gal-Xyl-HS proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10464802", "map_id": "none", "name": "EXT1:EXT2 transfers GlcA to heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10464800", "map_id": "none", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10464795", "map_id": "Q8MRE7", "name": "Hs3st-A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10497796", "map_id": "none", "name": "NFkB inhibitor binds NFkB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437411", "map_id": "none", "name": "NFKB1(1-433), NFKB2(1-454):RELA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P98149", "map_id": "P98149", "name": "Dif", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Dif", "map_id": "Dif", "name": "Dif", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437415", "map_id": "Q03017", "name": "cact", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10437417", "map_id": "none", "name": "NFkB inhibitor:NFkB complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q03017", "map_id": "Q03017", "name": "phospho-cact", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-cact", "map_id": "phospho-cact", "name": "phospho-cact", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10437457", "map_id": "none", "name": "NFkB complex is transported from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437455", "map_id": "none", "name": "NFkB Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468309", "map_id": "none", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468258", "map_id": "none", "name": "TCF/LEF:CTNNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8IMA8", "map_id": "Q8IMA8", "name": "pan", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085432", "map_id": "FBgn0085432", "name": "pan", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447242", "map_id": "M9MS40", "name": "nej", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0261617", "map_id": "FBgn0261617", "name": "nej", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468307", "map_id": "none", "name": "TCF/LEF:CTNNB1:CBP/p300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9MS40", "map_id": "M9MS40", "name": "nej", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468260", "map_id": "none", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468256", "map_id": "none", "name": "TCF/LEF:TLE:HDAC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P16371", "map_id": "P16371", "name": "GRO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "GRO", "map_id": "GRO", "name": "GRO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94517", "map_id": "Q94517", "name": "HDAC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "HDAC1", "map_id": "HDAC1", "name": "HDAC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441673", "map_id": "P18824", "name": "arm", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10457450", "map_id": "Q94517", "name": "HDAC1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10468252", "map_id": "none", "name": "TLE tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468305", "map_id": "none", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434736", "map_id": "Q94546", "name": "Atu", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0019637", "map_id": "FBgn0019637", "name": "Atu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434726", "map_id": "Q9VHI1", "name": "hyx", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0037657", "map_id": "FBgn0037657", "name": "hyx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468303", "map_id": "none", "name": "TCF/LEF:CTNNB1:PAF1-like complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VHI1", "map_id": "Q9VHI1", "name": "hyx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94546", "map_id": "Q94546", "name": "Atu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468464", "map_id": "none", "name": "Recruitment of SET1 methyltransferase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468432", "map_id": "Q8IRW8", "name": "trr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0023518", "map_id": "FBgn0023518", "name": "trr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468437", "map_id": "Q94545", "name": "ash2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0000139", "map_id": "FBgn0000139", "name": "ash2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465286", "map_id": "Q9VM47", "name": "Mnn1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0031885", "map_id": "FBgn0031885", "name": "Mnn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468442", "map_id": "Q9VPH8", "name": "Rbbp5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0036973", "map_id": "FBgn0036973", "name": "Rbbp5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468460", "map_id": "none", "name": "TCF/LEF:CTNNB1:BCL9:PYGO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V9W8", "map_id": "Q9V9W8", "name": "PYGO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PYGO", "map_id": "PYGO", "name": "PYGO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q961D9", "map_id": "Q961D9", "name": "LGS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LGS", "map_id": "LGS", "name": "LGS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468462", "map_id": "none", "name": "TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VPH8", "map_id": "Q9VPH8", "name": "Rbbp5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM47", "map_id": "Q9VM47", "name": "Mnn1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94545", "map_id": "Q94545", "name": "ash2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRW8", "map_id": "Q8IRW8", "name": "trr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441675", "map_id": "none", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440609", "map_id": "P18824", "name": "arm", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10468687", "map_id": "none", "name": "RNF146 binds RibC-AXIN:TNKS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468683", "map_id": "none", "name": "RibC-AXIN:TNKS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VBP3", "map_id": "Q9VBP3", "name": "Tnks", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027508", "map_id": "FBgn0027508", "name": "Tnks", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V407", "map_id": "Q9V407", "name": "phospho-Axn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-Axn", "map_id": "phospho-Axn", "name": "phospho-Axn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468669", "map_id": "B7Z078", "name": "Rnf146", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036897", "map_id": "FBgn0036897", "name": "Rnf146", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468685", "map_id": "none", "name": "RibC-AXIN:TNKS:RNF146", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B7Z078", "map_id": "B7Z078", "name": "Rnf146", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468716", "map_id": "none", "name": "Ub-RibC-AXIN is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468701", "map_id": "none", "name": "Ub-RibC-AXIN:TNKS:RNF146", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10468679", "map_id": "Q9VBP3", "name": "Tnks", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10468694", "map_id": "none", "name": "Tankyrase ADP-ribosylates AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468691", "map_id": "none", "name": "AXIN:TNKS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_197277", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10470006", "map_id": "none", "name": "SMURF2 binds AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437960", "map_id": "Q9V853", "name": "Smurf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0029006", "map_id": "FBgn0029006", "name": "Smurf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10440493", "map_id": "Q9V407", "name": "Axn", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469994", "map_id": "none", "name": "AXIN:SMURF2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V853", "map_id": "Q9V853", "name": "Smurf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470021", "map_id": "none", "name": "Ubiquitinated AXIN is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10470001", "map_id": "none", "name": "ub-AXIN:SMURF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10470004", "map_id": "none", "name": "AXIN is ubiquitinated by SMURF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10468706", "map_id": "none", "name": "Tankyrase binds AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10468704", "map_id": "none", "name": "RNF146 ubiquitinates ADP-ribosylated AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10468714", "map_id": "none", "name": "USP34 deubiquitinates AXIN1,AXIN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468711", "map_id": "Q9VC56", "name": "puf", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0039214", "map_id": "FBgn0039214", "name": "puf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472015", "map_id": "none", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10472011", "map_id": "B7Z002", "name": "kis", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0266557", "map_id": "FBgn0266557", "name": "kis", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472013", "map_id": "none", "name": "CTNNB1:CHD8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B7Z002", "map_id": "B7Z002", "name": "kis", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475439", "map_id": "none", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475435", "map_id": "none", "name": "SOX4,SOX13,SOX17", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24533", "map_id": "Q24533", "name": "D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000411", "map_id": "FBgn0000411", "name": "D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P40657", "map_id": "P40657", "name": "Sox15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005613", "map_id": "FBgn0005613", "name": "Sox15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P40656", "map_id": "P40656", "name": "Sox14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005612", "map_id": "FBgn0005612", "name": "Sox14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PFG6", "map_id": "M9PFG6", "name": "Sox21a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036411", "map_id": "FBgn0036411", "name": "Sox21a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PCZ7", "map_id": "M9PCZ7", "name": "SoxN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029123", "map_id": "FBgn0029123", "name": "SoxN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PCG2", "map_id": "M9PCG2", "name": "Sox21b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042630", "map_id": "FBgn0042630", "name": "Sox21b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q59DN5", "map_id": "Q59DN5", "name": "Sox102F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039938", "map_id": "FBgn0039938", "name": "Sox102F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475437", "map_id": "none", "name": "TCF/LEF:CTNNB1:SOX4,SOX13,SOX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468798", "map_id": "none", "name": "XPO1 binds the beta-catenin:CBY complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468794", "map_id": "none", "name": "YWHAZ:p-S20-CBY:CTNNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B9A0M5", "map_id": "B9A0M5", "name": "phospho-Cby", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0067317", "map_id": "FBgn0067317", "name": "phospho-Cby", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P29310", "map_id": "P29310", "name": "14-3-3zeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "14-3-3zeta", "map_id": "14-3-3zeta", "name": "14-3-3zeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437629", "map_id": "Q9TVM2", "name": "emb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0020497", "map_id": "FBgn0020497", "name": "emb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468796", "map_id": "none", "name": "XPO1:YWHAZ:p-S20-CBY1:CTNNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TVM2", "map_id": "Q9TVM2", "name": "emb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468427", "map_id": "none", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468421", "map_id": "none", "name": "TCF/LEF:CTNNB1:APC:CTBP:BTRC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O46036", "map_id": "O46036", "name": "CtBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y1T2", "map_id": "Q9Y1T2", "name": "Apc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Apc2", "map_id": "Apc2", "name": "Apc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAS9", "map_id": "Q9VAS9", "name": "Apc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015589", "map_id": "FBgn0015589", "name": "Apc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468423", "map_id": "none", "name": "TLE1:HDAC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10468425", "map_id": "none", "name": "APC:CTBP:CTNNB1:BTRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468810", "map_id": "none", "name": "AKT phosphorylates CBY1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468785", "map_id": "none", "name": "CBY1:CTNNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10468792", "map_id": "none", "name": "pS20-CBY1:CTNNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468345", "map_id": "none", "name": "XIAP dissociates from ub-TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468338", "map_id": "none", "name": "ub-TLE:XIAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24307", "map_id": "Q24307", "name": "Diap2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Diap2", "map_id": "Diap2", "name": "Diap2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24306", "map_id": "Q24306", "name": "Diap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Diap1", "map_id": "Diap1", "name": "Diap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468336", "map_id": "none", "name": "ub-TLE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10468315", "map_id": "none", "name": "Homologues of XIAP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468808", "map_id": "none", "name": "YWHAZ binds p-CBY:CTNNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10451202", "map_id": "P29310", "name": "14-3-3zeta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10468343", "map_id": "none", "name": "XIAP binds TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468317", "map_id": "none", "name": "TLE:XIAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468806", "map_id": "none", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468804", "map_id": "none", "name": "XPO1:YWHAZ:p-S20-CBY1:CTNNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10468341", "map_id": "none", "name": "XIAP monoubiquinates TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10474292", "map_id": "none", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474288", "map_id": "none", "name": "SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VA17", "map_id": "Q9VA17", "name": "Sox100B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024288", "map_id": "FBgn0024288", "name": "Sox100B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474290", "map_id": "none", "name": "CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468787", "map_id": "none", "name": "CBY1 binds beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468783", "map_id": "B9A0M5", "name": "Cby", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10441753", "map_id": "none", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10441725", "map_id": "none", "name": "WNT:FZD:LRP5/6:DVL:AXIN:GSK3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P51140", "map_id": "P51140", "name": "phospho-dsh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-dsh", "map_id": "phospho-dsh", "name": "phospho-dsh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P09615", "map_id": "P09615", "name": "WG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WG", "map_id": "WG", "name": "WG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18537", "map_id": "P18537", "name": "FZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FZ", "map_id": "FZ", "name": "FZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLZ6", "map_id": "Q9VLZ6", "name": "phospho-Dmel\\CG6739", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031926", "map_id": "FBgn0031926", "name": "phospho-Dmel\\CG6739", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQA9", "map_id": "Q8IQA9", "name": "phospho-Culd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035880", "map_id": "FBgn0035880", "name": "phospho-Culd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V6B0", "map_id": "Q4V6B0", "name": "phospho-Dmel\\CG6553", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033880", "map_id": "FBgn0033880", "name": "phospho-Dmel\\CG6553", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441750", "map_id": "none", "name": "WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A1Z9D7", "map_id": "A1Z9D7", "name": "arr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000119", "map_id": "FBgn0000119", "name": "arr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459892", "map_id": "none", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441723", "map_id": "none", "name": "WNT:FZD:LRP5/6:DVL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10441677", "map_id": "none", "name": "GSK3B:AXIN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10468814", "map_id": "none", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10460946", "map_id": "none", "name": "Homologues of PIP5K1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W2R3", "map_id": "Q9W2R3", "name": "sktl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016984", "map_id": "FBgn0016984", "name": "sktl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441717", "map_id": "P51140", "name": "phospho-dsh", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10468812", "map_id": "none", "name": "ppDVL:PIP5K1B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10468824", "map_id": "none", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_392417", "map_id": "CHEBI:17526", "name": "PI4P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10468821", "map_id": "none", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441766", "map_id": "P51140", "name": "phospho-dsh", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10468818", "map_id": "O76324", "name": "dco", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441793", "map_id": "none", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441759", "map_id": "P51140", "name": "dsh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10471507", "map_id": "none", "name": "Canonical WNT signaling through the atypical receptor RYK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10471501", "map_id": "Q9V422", "name": "dnt", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0024245", "map_id": "FBgn0024245", "name": "dnt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471503", "map_id": "none", "name": "RYK-binding WNTs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "P28466", "map_id": "P28466", "name": "Wnt5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010194", "map_id": "FBgn0010194", "name": "Wnt5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471505", "map_id": "none", "name": "RYK:WNTs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9V422", "map_id": "Q9V422", "name": "dnt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470012", "map_id": "none", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10470008", "map_id": "Q9W326", "name": "CG3003", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0261931", "map_id": "FBgn0261931", "name": "CG3003", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470010", "map_id": "none", "name": "DVL1:HECW1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W326", "map_id": "Q9W326", "name": "CG3003", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470023", "map_id": "none", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10470014", "map_id": "none", "name": "ub-DVL1:HECW1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10459910", "map_id": "none", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459898", "map_id": "none", "name": "DVL:CUL3:KLHL12:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IP45", "map_id": "Q8IP45", "name": "Cul3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261268", "map_id": "FBgn0261268", "name": "Cul3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10459907", "map_id": "none", "name": "ub-DVL:CUL3:KLHL12:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10470017", "map_id": "none", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10496688", "map_id": "none", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496685", "map_id": "none", "name": "RHOU:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q0KHU4", "map_id": "Q0KHU4", "name": "RhoU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0083940", "map_id": "FBgn0083940", "name": "RhoU", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496660", "map_id": "none", "name": "RHOU:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496683", "map_id": "none", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496679", "map_id": "none", "name": "RHOU effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VXE5", "map_id": "Q9VXE5", "name": "mbt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025743", "map_id": "FBgn0025743", "name": "mbt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIS1", "map_id": "Q9VIS1", "name": "CdGAPr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032821", "map_id": "FBgn0032821", "name": "CdGAPr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496681", "map_id": "none", "name": "RHOU:GTP:RHOU effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496403", "map_id": "none", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10440312", "map_id": "Q9VW59", "name": "RhoGDI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10496401", "map_id": "none", "name": "RAC1:GDP:RAC1 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VW59", "map_id": "Q9VW59", "name": "RhoGDI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "RhoGDI", "map_id": "RhoGDI", "name": "RhoGDI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496358", "map_id": "none", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496355", "map_id": "none", "name": "RAC1 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VWL7", "map_id": "Q9VWL7", "name": "RhoGAP18B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261461", "map_id": "FBgn0261461", "name": "RhoGAP18B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2JEI9", "map_id": "X2JEI9", "name": "RhoGAP19D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031118", "map_id": "FBgn0031118", "name": "RhoGAP19D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDS5", "map_id": "Q9VDS5", "name": "RhoGAP92B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038747", "map_id": "FBgn0038747", "name": "RhoGAP92B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDG2", "map_id": "Q9VDG2", "name": "Rlip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026056", "map_id": "FBgn0026056", "name": "Rlip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E938", "map_id": "Q0E938", "name": "anon-WO0153538.32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028494", "map_id": "FBgn0028494", "name": "anon-WO0153538.32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4A9", "map_id": "Q9W4A9", "name": "RhoGAP5A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029778", "map_id": "FBgn0029778", "name": "RhoGAP5A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9S7", "map_id": "Q9V9S7", "name": "RhoGAP100F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039883", "map_id": "FBgn0039883", "name": "RhoGAP100F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDE9", "map_id": "Q9VDE9", "name": "RhoGAP93B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "RhoGAP93B", "map_id": "RhoGAP93B", "name": "RhoGAP93B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7Z058", "map_id": "B7Z058", "name": "RhoGAP71E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036518", "map_id": "FBgn0036518", "name": "RhoGAP71E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496311", "map_id": "none", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496308", "map_id": "none", "name": "RAC1 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P25157", "map_id": "P25157", "name": "cta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000384", "map_id": "FBgn0000384", "name": "cta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAS8", "map_id": "Q9VAS8", "name": "spg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264324", "map_id": "FBgn0264324", "name": "spg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498558", "map_id": "none", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498556", "map_id": "none", "name": "RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10496399", "map_id": "none", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496395", "map_id": "none", "name": "RAC1 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O97111", "map_id": "O97111", "name": "par-6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026192", "map_id": "FBgn0026192", "name": "par-6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7YZT5", "map_id": "B7YZT5", "name": "Pld", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286511", "map_id": "FBgn0286511", "name": "Pld", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7T0", "map_id": "A1Z7T0", "name": "phospho-Pkn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020621", "map_id": "FBgn0020621", "name": "phospho-Pkn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1B0", "map_id": "Q9W1B0", "name": "gek", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023081", "map_id": "FBgn0023081", "name": "gek", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K490", "map_id": "Q7K490", "name": "CT14564", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033996", "map_id": "FBgn0033996", "name": "CT14564", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PE53", "map_id": "M9PE53", "name": "mwh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264272", "map_id": "FBgn0264272", "name": "mwh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496397", "map_id": "none", "name": "RAC1:GTP:RAC1 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498562", "map_id": "none", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498560", "map_id": "none", "name": "CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10496452", "map_id": "none", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496432", "map_id": "none", "name": "CDC42:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10496449", "map_id": "none", "name": "CDC42 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VX92", "map_id": "Q9VX92", "name": "RhoGAP15B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030808", "map_id": "FBgn0030808", "name": "RhoGAP15B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T0G4", "map_id": "Q8T0G4", "name": "conu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039994", "map_id": "FBgn0039994", "name": "conu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTU3", "map_id": "Q9VTU3", "name": "RhoGAP68F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036257", "map_id": "FBgn0036257", "name": "RhoGAP68F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496438", "map_id": "none", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496436", "map_id": "none", "name": "CDC42:GDP:CDC42 GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496445", "map_id": "none", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496442", "map_id": "none", "name": "CDC42 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1ZBA1", "map_id": "A1ZBA1", "name": "GEFmeso", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050115", "map_id": "FBgn0050115", "name": "GEFmeso", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0S2", "map_id": "Q9W0S2", "name": "RhoGEF3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264707", "map_id": "FBgn0264707", "name": "RhoGEF3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KU89", "map_id": "Q7KU89", "name": "Pura", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035802", "map_id": "FBgn0035802", "name": "Pura", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K4E0", "map_id": "Q7K4E0", "name": "CG12183", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050440", "map_id": "FBgn0050440", "name": "CG12183", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498596", "map_id": "none", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498572", "map_id": "none", "name": "RHOF:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10498592", "map_id": "none", "name": "RHOF effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P48608", "map_id": "P48608", "name": "dia", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011202", "map_id": "FBgn0011202", "name": "dia", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498594", "map_id": "none", "name": "RHOF:GTP:RHOF effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498649", "map_id": "none", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498570", "map_id": "none", "name": "RHOF:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10498646", "map_id": "none", "name": "RHOF GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498575", "map_id": "none", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10496723", "map_id": "none", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496719", "map_id": "none", "name": "RHOBTB1 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VJ79", "map_id": "Q9VJ79", "name": "Pde11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085370", "map_id": "FBgn0085370", "name": "Pde11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFI9", "map_id": "Q9VFI9", "name": "Pde6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038237", "map_id": "FBgn0038237", "name": "Pde6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496695", "map_id": "none", "name": "RHOBTB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "M9PG08", "map_id": "M9PG08", "name": "RhoBTB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036980", "map_id": "FBgn0036980", "name": "RhoBTB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496721", "map_id": "none", "name": "RHOBTB1:GTP:RHOBTB1 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10496697", "map_id": "none", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10496693", "map_id": "M9PG08", "name": "RhoBTB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "reaction_10496752", "map_id": "none", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10496748", "map_id": "none", "name": "RHOBTB2 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VVE5", "map_id": "Q9VVE5", "name": "Rbp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260943", "map_id": "FBgn0260943", "name": "Rbp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496727", "map_id": "none", "name": "RHOBTB2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10496750", "map_id": "none", "name": "RHOBTB2:GTP:RHOBTB2 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10496732", "map_id": "none", "name": "RHOBTB2 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496725", "map_id": "M9PG08", "name": "RhoBTB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "species_10496729", "map_id": "none", "name": "HSP90:CDC37", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q24276", "map_id": "Q24276", "name": "Cdc37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011573", "map_id": "FBgn0011573", "name": "Cdc37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496496", "map_id": "none", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496460", "map_id": "none", "name": "RHOD:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475550", "map_id": "none", "name": "RHOD:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10498627", "map_id": "none", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498625", "map_id": "none", "name": "RHOD:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10496468", "map_id": "none", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496456", "map_id": "none", "name": "RHOD:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10496465", "map_id": "none", "name": "RHOD GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VX32", "map_id": "Q9VX32", "name": "RhoGAPp190", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "RhoGAPp190", "map_id": "RhoGAPp190", "name": "RhoGAPp190", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2JDY8", "map_id": "X2JDY8", "name": "Graf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030685", "map_id": "FBgn0030685", "name": "Graf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498644", "map_id": "none", "name": "RHOD binds effectors at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10498640", "map_id": "none", "name": "RHOD Golgi membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q8SX68", "map_id": "Q8SX68", "name": "Naus", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034308", "map_id": "FBgn0034308", "name": "Naus", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498642", "map_id": "none", "name": "RHOD:GTP:RHOD Golgi membrane effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10498613", "map_id": "none", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498611", "map_id": "none", "name": "RHOD:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10498621", "map_id": "none", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10498617", "map_id": "none", "name": "RHOD mitochondrial outer membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10498619", "map_id": "none", "name": "RHOD:GTP:RHOD mitochondrial outer membrane effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10496494", "map_id": "none", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496490", "map_id": "none", "name": "RHOD endosome effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VPY3", "map_id": "Q9VPY3", "name": "Charon", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031317", "map_id": "FBgn0031317", "name": "Charon", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496492", "map_id": "none", "name": "RHOD:GTP:RHOD endosome effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10496463", "map_id": "none", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10498607", "map_id": "none", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498603", "map_id": "none", "name": "RHOD plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P48603", "map_id": "P48603", "name": "cpb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011570", "map_id": "FBgn0011570", "name": "cpb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ26", "map_id": "Q9VJ26", "name": "Swip-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032731", "map_id": "FBgn0032731", "name": "Swip-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PE71", "map_id": "M9PE71", "name": "nSyb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013342", "map_id": "FBgn0013342", "name": "nSyb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18489", "map_id": "P18489", "name": "Syb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003660", "map_id": "FBgn0003660", "name": "Syb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18091", "map_id": "P18091", "name": "Actn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000667", "map_id": "FBgn0000667", "name": "Actn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02645", "map_id": "Q02645", "name": "hts", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263391", "map_id": "FBgn0263391", "name": "hts", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76742", "map_id": "O76742", "name": "Rab7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015795", "map_id": "FBgn0015795", "name": "Rab7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VU84", "map_id": "Q9VU84", "name": "Abp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036372", "map_id": "FBgn0036372", "name": "Abp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IPI3", "map_id": "Q8IPI3", "name": "Ndae1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259111", "map_id": "FBgn0259111", "name": "Ndae1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW40", "map_id": "Q9VW40", "name": "TORIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036908", "map_id": "FBgn0036908", "name": "TORIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498605", "map_id": "none", "name": "RHOD:GTP:RHOD plasma membrane effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496514", "map_id": "none", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496508", "map_id": "none", "name": "RAC2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P48554", "map_id": "P48554", "name": "Rac2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014011", "map_id": "FBgn0014011", "name": "Rac2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496512", "map_id": "none", "name": "ARHGDIA:RAC2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496532", "map_id": "none", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434896", "map_id": "none", "name": "RAC2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10496529", "map_id": "none", "name": "RAC2 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "X2JC00", "map_id": "X2JC00", "name": "RhoGAP1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025836", "map_id": "FBgn0025836", "name": "RhoGAP1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496534", "map_id": "none", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475589", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10498823", "map_id": "none", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498821", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10496522", "map_id": "none", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496518", "map_id": "none", "name": "RAC2 plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10496520", "map_id": "none", "name": "RAC2:GTP:RAC2 cytosolic effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498813", "map_id": "none", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10498797", "map_id": "none", "name": "RAC2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10498809", "map_id": "none", "name": "RAC2 mitochondrial effectors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10498811", "map_id": "none", "name": "RAC2:GTP:RAC2 mitochondrial effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10496527", "map_id": "none", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496524", "map_id": "none", "name": "RAC2 GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498815", "map_id": "none", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10496786", "map_id": "none", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496782", "map_id": "none", "name": "RHOV effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10496756", "map_id": "none", "name": "RHOV:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10496784", "map_id": "none", "name": "RHOV:GTP:RHOV effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496790", "map_id": "none", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496788", "map_id": "none", "name": "RHOV:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495680", "map_id": "none", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495677", "map_id": "none", "name": "RHOA GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1ZAW3", "map_id": "A1ZAW3", "name": "RhoGAP54D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034249", "map_id": "FBgn0034249", "name": "RhoGAP54D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9XVN1", "map_id": "H9XVN1", "name": "RhoGAP102A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259216", "map_id": "FBgn0259216", "name": "RhoGAP102A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JR05", "map_id": "A8JR05", "name": "cv-c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0285955", "map_id": "FBgn0285955", "name": "cv-c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496244", "map_id": "none", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496242", "map_id": "none", "name": "RHOA GDIs:RHOA:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496248", "map_id": "none", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496246", "map_id": "none", "name": "RHOA:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10495532", "map_id": "none", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495529", "map_id": "none", "name": "RHOA GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IQ97", "map_id": "Q8IQ97", "name": "pbl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003041", "map_id": "FBgn0003041", "name": "pbl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PHU0", "map_id": "M9PHU0", "name": "CG12432", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263706", "map_id": "FBgn0263706", "name": "CG12432", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW85", "map_id": "Q9VW85", "name": "CG13812", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261556", "map_id": "FBgn0261556", "name": "CG13812", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KVD1", "map_id": "Q7KVD1", "name": "trio", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024277", "map_id": "FBgn0024277", "name": "trio", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496302", "map_id": "none", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496298", "map_id": "none", "name": "RHOA plasma membrane effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XYY9", "map_id": "Q9XYY9", "name": "Rhp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026374", "map_id": "FBgn0026374", "name": "Rhp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W179", "map_id": "Q9W179", "name": "Slik", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035001", "map_id": "FBgn0035001", "name": "Slik", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4P1", "map_id": "Q9V4P1", "name": "scra", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261385", "map_id": "FBgn0261385", "name": "scra", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9MSM5", "map_id": "M9MSM5", "name": "DAAM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025641", "map_id": "FBgn0025641", "name": "DAAM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496300", "map_id": "none", "name": "RHOA:GTP:cytosolic RHOA effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496569", "map_id": "none", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496562", "map_id": "none", "name": "RHOJ:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10496564", "map_id": "none", "name": "RHOJ:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10496566", "map_id": "none", "name": "RHOJ GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496572", "map_id": "none", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10457618", "map_id": "Q9VPI9", "name": "Zir", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031216", "map_id": "FBgn0031216", "name": "Zir", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496609", "map_id": "none", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496591", "map_id": "none", "name": "RHOQ:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10496605", "map_id": "none", "name": "RHOQ effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A8JNK4", "map_id": "A8JNK4", "name": "Cip4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035533", "map_id": "FBgn0035533", "name": "Cip4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496607", "map_id": "none", "name": "RHOQ:GTP:RHOQ effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496614", "map_id": "none", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496593", "map_id": "none", "name": "RHOQ:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10496611", "map_id": "none", "name": "RHOQ GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496598", "map_id": "none", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496595", "map_id": "none", "name": "RHOQ GAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496826", "map_id": "none", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496824", "map_id": "none", "name": "RHOQ:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "reaction_10496626", "map_id": "none", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496622", "map_id": "none", "name": "RHOH:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10496624", "map_id": "none", "name": "RHOH:GTP:RHOH GDIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496628", "map_id": "none", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496620", "map_id": "none", "name": "Homologues of RHOH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496653", "map_id": "none", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496649", "map_id": "none", "name": "RHOH effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8INJ8", "map_id": "Q8INJ8", "name": "Csk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262081", "map_id": "FBgn0262081", "name": "Csk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496651", "map_id": "none", "name": "RHOH:GTP:RHOH effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10455477", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_915149", "map_id": "CHEBI:59092", "name": "(GlcNAc)2 (Man)9", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_964752", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964740", "map_id": "CHEBI:59087", "name": "(GlcNAc)2 (Man)5 (Asn)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10455474", "map_id": "none", "name": "MAN1A1/A2/C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P53624", "map_id": "P53624", "name": "alpha-Man-Ia", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259170", "map_id": "FBgn0259170", "name": "alpha-Man-Ia", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IMK0", "map_id": "Q8IMK0", "name": "alpha-Man-Ic", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051202", "map_id": "FBgn0051202", "name": "alpha-Man-Ic", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455523", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964828", "map_id": "CHEBI:60637", "name": "(GlcNAc)2 (Man)7bc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10455521", "map_id": "none", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964831", "map_id": "none", "name": "(GlcNAc)2 (Man)8 glycans", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "CHEBI:60629", "map_id": "CHEBI:60629", "name": "CHEBI:60629", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60628", "map_id": "CHEBI:60628", "name": "CHEBI:60628", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:60627", "map_id": "CHEBI:60627", "name": "CHEBI:60627", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461309", "map_id": "none", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090069", "map_id": "CHEBI:63807", "name": "Heparan sulfate chain(4)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090080", "map_id": "CHEBI:63808", "name": "Heparan sulfate chain(5)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678743", "map_id": "CHEBI:17411", "name": "GlcNAc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10461306", "map_id": "Q9VLL5", "name": "ESTS:172F5T", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0014417", "map_id": "FBgn0014417", "name": "ESTS:172F5T", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464861", "map_id": "none", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_76183", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2090045", "map_id": "CHEBI:63811", "name": "Heparan chain(1)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090053", "map_id": "CHEBI:63645", "name": "Heparan chain(2)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10461235", "map_id": "none", "name": "HGSNAT oligomer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q9W4F7", "map_id": "Q9W4F7", "name": "Dmel\\CG6903", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029737", "map_id": "FBgn0029737", "name": "Dmel\\CG6903", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464859", "map_id": "none", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090075", "map_id": "CHEBI:63503", "name": "linker chain(2)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090063", "map_id": "CHEBI:15936", "name": "D-xylose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10463705", "map_id": "none", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461260", "map_id": "none", "name": "HS/HPIN-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10460901", "map_id": "none", "name": "HS/HPIN-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10464857", "map_id": "none", "name": "SGSH hydrolyses Heparan sulfate chain(7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090070", "map_id": "CHEBI:63810", "name": "Heparan sulfate chain(7)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10461290", "map_id": "Q9VE24", "name": "Sgsh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0038660", "map_id": "FBgn0038660", "name": "Sgsh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464855", "map_id": "none", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065212", "map_id": "CHEBI:63505", "name": "CS/HS precursor", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10461238", "map_id": "none", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_2090040", "map_id": "CHEBI:63806", "name": "Heparan sulfate chain(3)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10461301", "map_id": "none", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090033", "map_id": "CHEBI:63666", "name": "Heparan sulfate chain(1)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2090072", "map_id": "CHEBI:63805", "name": "Heparan sulfate chain(2)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678617", "map_id": "CHEBI:28481", "name": "aldehydo-L-iduronic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10461298", "map_id": "Q9VKJ8", "name": "Dmel\\CG6201", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0032343", "map_id": "FBgn0032343", "name": "Dmel\\CG6201", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464853", "map_id": "none", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2090055", "map_id": "CHEBI:63809", "name": "Heparan sulfate chain(6)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10461293", "map_id": "none", "name": "SGSH hydrolyses Heparan sulfate chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10461228", "map_id": "none", "name": "IDS hydrolyses Heparan sulfate chain(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10461225", "map_id": "none", "name": "IDS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9VZP8", "map_id": "Q9VZP8", "name": "Ids", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035445", "map_id": "FBgn0035445", "name": "Ids", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460935", "map_id": "none", "name": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10460923", "map_id": "none", "name": "HS core proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10460932", "map_id": "none", "name": "HPSE dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9VE79", "map_id": "Q9VE79", "name": "Dmel\\CG14309", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038611", "map_id": "FBgn0038611", "name": "Dmel\\CG14309", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461351", "map_id": "none", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1678868", "map_id": "CHEBI:4178", "name": "GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10461348", "map_id": "none", "name": "GUSB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "A1ZBG9", "map_id": "A1ZBG9", "name": "Dmel\\CG15117", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034417", "map_id": "FBgn0034417", "name": "Dmel\\CG15117", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_427963", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10461285", "map_id": "none", "name": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461280", "map_id": "none", "name": "HS core proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_2090023", "map_id": "CHEBI:63666", "name": "Heparan sulfate chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10461282", "map_id": "Q9VE79", "name": "Dmel\\CG14309", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10496818", "map_id": "none", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496814", "map_id": "none", "name": "RHOT2 effectors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q960V3", "map_id": "Q960V3", "name": "milt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262872", "map_id": "FBgn0262872", "name": "milt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YU24", "map_id": "Q7YU24", "name": "Marf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029870", "map_id": "FBgn0029870", "name": "Marf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18412", "map_id": "O18412", "name": "fzo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011596", "map_id": "FBgn0011596", "name": "fzo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496796", "map_id": "none", "name": "RHOT1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q8IMX7", "map_id": "Q8IMX7", "name": "Miro", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Miro", "map_id": "Miro", "name": "Miro", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496816", "map_id": "none", "name": "RHOT2:GTP:RHOT2 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10496820", "map_id": "none", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496798", "map_id": "none", "name": "RHOT1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10448207", "map_id": "none", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_425969", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_83910", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_425958", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10448204", "map_id": "none", "name": "SLC9A7/8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VPJ1", "map_id": "Q9VPJ1", "name": "Nhe1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026787", "map_id": "FBgn0026787", "name": "Nhe1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IPJ4", "map_id": "Q8IPJ4", "name": "Nhe3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028703", "map_id": "FBgn0028703", "name": "Nhe3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448172", "map_id": "none", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_425999", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_425977", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_173031", "compartment_display": "late endosome lumen", "complex": "false" }, { "id": "species_10448169", "map_id": "Q8IPJ4", "name": "Nhe3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "reaction_10448195", "map_id": "none", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_74113", "map_id": "CHEBI:29101", "name": "Na+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351626", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10448184", "map_id": "B7YZY2", "name": "Nhe2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0040297", "map_id": "FBgn0040297", "name": "Nhe2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448179", "map_id": "none", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_425978", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171043", "compartment_display": "early endosome lumen", "complex": "false" }, { "id": "species_425971", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171043", "compartment_display": "early endosome lumen", "complex": "false" }, { "id": "species_10448174", "map_id": "Q8IPJ4", "name": "Nhe3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_209074", "map_id": "none", "name": "WG, FZ and ARR bind to each other", "reversible": "false", "notes": "The extracellular ligand Wingless (WG) binds to the extracellular domains of the plasma membrane Frizzled (FZ/FZ2) and Arrow (ARR) receptors. Both of these transmembrane receptors additionally interact with each other.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_206202", "map_id": "Q95V09", "name": "ARR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_205797", "map_id": "P09615", "name": "WG", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_206546", "map_id": "none", "name": "FZ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VVX3", "map_id": "Q9VVX3", "name": "FZ2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FZ2", "map_id": "FZ2", "name": "FZ2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_206872", "map_id": "none", "name": "WG:FZ:ARR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95V09", "map_id": "Q95V09", "name": "ARR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ARR", "map_id": "ARR", "name": "ARR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_209108", "map_id": "none", "name": "Membrane-bound GISH binds to ARR receptor complex", "reversible": "false", "notes": "The plasma membrane tethered CKIgamma orthologue, GISH, complexes with the cytoplasmic tail of Arrow (ARR).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_205695", "map_id": "Q86BR9", "name": "GISH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_206907", "map_id": "none", "name": "WG:FZ:ARR:GISH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86BR9", "map_id": "Q86BR9", "name": "GISH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "GISH", "map_id": "GISH", "name": "GISH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_209135", "map_id": "none", "name": "GISH further phosphorylates ARR in the receptor complex", "reversible": "false", "notes": "The bound kinase GISH phosphorylates two further residues on Arrow's (ARR) tail. Thr1493 and Thr1479 in Human LRP6 are phosphorylated by CKIgamma.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206800", "map_id": "none", "name": "WG:FZ:Phospho ARR:GISH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_206613", "map_id": "none", "name": "WG:FZ:Phospho (3 sites) ARR:GISH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209118", "map_id": "none", "name": "Membrane localised SGG phosphorylates ARR", "reversible": "false", "notes": "The resulting transmembrane co-receptor complex is now primed for phosphorylation on the C-terminal tail of Arrow (ARR) by a membrane localised Shaggy (SGG). Ser1490 in Human LRP6 is phosphorylated by GSK3beta.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5263693", "map_id": "P18431", "name": "SGG", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10481336", "map_id": "none", "name": "PRTPRF, PTPRS, PTPRD bind LRRC4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10481332", "map_id": "none", "name": "Homologues of LRRC4B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W266", "map_id": "Q9W266", "name": "wdp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034718", "map_id": "FBgn0034718", "name": "wdp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P12024", "map_id": "P12024", "name": "chp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267435", "map_id": "FBgn0267435", "name": "chp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446397", "map_id": "P16621", "name": "Lar", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0000464", "map_id": "FBgn0000464", "name": "Lar", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10481334", "map_id": "none", "name": "LRRC4B:PTPRF,PTPRS,PTPRD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P16621", "map_id": "P16621", "name": "Lar", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446403", "map_id": "none", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446392", "map_id": "none", "name": "Liprins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VU88", "map_id": "Q9VU88", "name": "Liprin-beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036376", "map_id": "FBgn0036376", "name": "Liprin-beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PCD4", "map_id": "M9PCD4", "name": "Liprin-alpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0046704", "map_id": "FBgn0046704", "name": "Liprin-alpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446401", "map_id": "none", "name": "LAR,PTPRS,PTPRD:Liprins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10481248", "map_id": "none", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442084", "map_id": "Q9VU84", "name": "Abp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10481244", "map_id": "none", "name": "NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A1Z9K8", "map_id": "A1Z9K8", "name": "Prosap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040752", "map_id": "FBgn0040752", "name": "Prosap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KT70", "map_id": "Q7KT70", "name": "Gli", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001987", "map_id": "FBgn0001987", "name": "Gli", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1B3", "map_id": "Q9W1B3", "name": "Dmel\\CG10339", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034972", "map_id": "FBgn0034972", "name": "Dmel\\CG10339", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIC7", "map_id": "Q9VIC7", "name": "Nlg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051146", "map_id": "FBgn0051146", "name": "Nlg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIC6", "map_id": "Q9VIC6", "name": "Nlg3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0083963", "map_id": "FBgn0083963", "name": "Nlg3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NGK5", "map_id": "Q9NGK5", "name": "Nlg2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031866", "map_id": "FBgn0031866", "name": "Nlg2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P31007", "map_id": "P31007", "name": "dlg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001624", "map_id": "FBgn0001624", "name": "dlg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W450", "map_id": "Q9W450", "name": "Grip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029830", "map_id": "FBgn0029830", "name": "Grip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K1T1", "map_id": "Q7K1T1", "name": "vlc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259978", "map_id": "FBgn0259978", "name": "vlc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10481246", "map_id": "none", "name": "NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10481136", "map_id": "none", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445828", "map_id": "Q24210", "name": "CASK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0013759", "map_id": "FBgn0013759", "name": "CASK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10481132", "map_id": "none", "name": "Protein 4.1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VFU8", "map_id": "Q9VFU8", "name": "yrt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004049", "map_id": "FBgn0004049", "name": "yrt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V8R9", "map_id": "Q9V8R9", "name": "cora", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010434", "map_id": "FBgn0010434", "name": "cora", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10481134", "map_id": "none", "name": "CASK:Protein 4.1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q24210", "map_id": "Q24210", "name": "CASK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488289", "map_id": "none", "name": "SALM1 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10488267", "map_id": "Q9VWI6", "name": "kek5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0031016", "map_id": "FBgn0031016", "name": "kek5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488250", "map_id": "none", "name": "NMDAR:PSD-95", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10488287", "map_id": "none", "name": "SALM1:NMDAR:PSD-95", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VWI6", "map_id": "Q9VWI6", "name": "kek5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488305", "map_id": "none", "name": "SALM4 binds flotillin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10488301", "map_id": "none", "name": "FLOT1(FLOT2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O61492", "map_id": "O61492", "name": "Flo2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264078", "map_id": "FBgn0264078", "name": "Flo2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488265", "map_id": "Q9VWI6", "name": "kek5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10488303", "map_id": "none", "name": "SALM4:FLOT1(FLOT2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10488275", "map_id": "none", "name": "SALMs 1-4 bind reticulon 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10488271", "map_id": "E1JHT6", "name": "Rtnl1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0053113", "map_id": "FBgn0053113", "name": "Rtnl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488273", "map_id": "none", "name": "SALM2,3(SALM1,4):RTN3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "E1JHT6", "map_id": "E1JHT6", "name": "Rtnl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488263", "map_id": "none", "name": "SALM2 associate with AMPA and NMDA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10488259", "map_id": "none", "name": "AMPA, NMDA receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9PHV5", "map_id": "M9PHV5", "name": "GluRIB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264000", "map_id": "FBgn0264000", "name": "GluRIB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVU7", "map_id": "Q9VVU7", "name": "Ir75d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036829", "map_id": "FBgn0036829", "name": "Ir75d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVL2", "map_id": "Q9VVL2", "name": "Ir75c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261401", "map_id": "FBgn0261401", "name": "Ir75c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVL1", "map_id": "Q9VVL1", "name": "Ir75a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036757", "map_id": "FBgn0036757", "name": "Ir75a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRL4", "map_id": "Q9VRL4", "name": "Ir64a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035604", "map_id": "FBgn0035604", "name": "Ir64a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIA5", "map_id": "Q9VIA5", "name": "Ir84a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037501", "map_id": "FBgn0037501", "name": "Ir84a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03445", "map_id": "Q03445", "name": "GluRIA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004619", "map_id": "FBgn0004619", "name": "GluRIA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488257", "map_id": "Q9VWI6", "name": "kek5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10488261", "map_id": "none", "name": "SALM2:AMPA, NMDA receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10488281", "map_id": "none", "name": "SALMs 1-3 bind to PSD-95 family members", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10488277", "map_id": "none", "name": "PSD-95 family", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10488279", "map_id": "none", "name": "SALMs 1-3:PSD-95 family", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10488252", "map_id": "none", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10488248", "map_id": "none", "name": "NMDA receptor complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10449288", "map_id": "none", "name": "Homologues of DLG4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10489100", "map_id": "none", "name": "SALM3 binds LAR-RPTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10488269", "map_id": "Q9VWI6", "name": "kek5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10489098", "map_id": "none", "name": "SALM3:LAR-RPTPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10488285", "map_id": "none", "name": "SALMs1-3 bind each other in cis interactions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10488283", "map_id": "none", "name": "SALM1,2,3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453051", "map_id": "none", "name": "Activation of GRIK3 homomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10446852", "map_id": "none", "name": "G-protein beta-gamma:PLC beta 1/2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P25455", "map_id": "P25455", "name": "Plc21C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004611", "map_id": "FBgn0004611", "name": "Plc21C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P26308", "map_id": "P26308", "name": "Gbeta13F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001105", "map_id": "FBgn0001105", "name": "Gbeta13F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P38040", "map_id": "P38040", "name": "Ggamma1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004921", "map_id": "FBgn0004921", "name": "Ggamma1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10453044", "map_id": "none", "name": "GRIK3 homomer glutamate complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W365", "map_id": "Q9W365", "name": "Ir8a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052704", "map_id": "FBgn0052704", "name": "Ir8a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW78", "map_id": "Q9VW78", "name": "Ir76b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036937", "map_id": "FBgn0036937", "name": "Ir76b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPV3", "map_id": "Q9VPV3", "name": "GluRIIC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0046113", "map_id": "FBgn0046113", "name": "GluRIIC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPI2", "map_id": "Q9VPI2", "name": "Ir21a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031209", "map_id": "FBgn0031209", "name": "Ir21a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMP4", "map_id": "Q9VMP4", "name": "GluRIIA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004620", "map_id": "FBgn0004620", "name": "GluRIIA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMP3", "map_id": "Q9VMP3", "name": "GluRIIB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020429", "map_id": "FBgn0020429", "name": "GluRIIB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDH6", "map_id": "Q9VDH6", "name": "Ir93a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259215", "map_id": "FBgn0259215", "name": "Ir93a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDH5", "map_id": "Q9VDH5", "name": "KaiR1D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038837", "map_id": "FBgn0038837", "name": "KaiR1D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4A0", "map_id": "Q9V4A0", "name": "DmelCG11155", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039927", "map_id": "FBgn0039927", "name": "DmelCG11155", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9TVI0", "map_id": "Q9TVI0", "name": "GluRIID", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028422", "map_id": "FBgn0028422", "name": "GluRIID", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0KIF2", "map_id": "Q0KIF2", "name": "Ekar", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039916", "map_id": "FBgn0039916", "name": "Ekar", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0KI42", "map_id": "Q0KI42", "name": "GluRIIE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051201", "map_id": "FBgn0051201", "name": "GluRIIE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E8N6", "map_id": "Q0E8N6", "name": "clumsy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026255", "map_id": "FBgn0026255", "name": "clumsy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E9NA96", "map_id": "E9NA96", "name": "Ir25a", "type": "complex_component", "sub_type": 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another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10451406", "map_id": "none", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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"sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053051", "map_id": "FBgn0053051", "name": "Dmel\\CG33051", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VD25", "map_id": "Q9VD25", "name": "POLR3F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038951", "map_id": "FBgn0038951", "name": "POLR3F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG60", "map_id": "Q9VG60", "name": "Dmel\\CG12267", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038057", "map_id": "FBgn0038057", "name": "Dmel\\CG12267", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24320", "map_id": "Q24320", "name": "RpII18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003275", "map_id": "FBgn0003275", "name": "RpII18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMX3", "map_id": "Q9VMX3", "name": "Dmel\\CG3756", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031657", "map_id": "FBgn0031657", "name": "Dmel\\CG3756", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JZF5", "map_id": "Q7JZF5", "name": "Rpb5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033571", "map_id": "FBgn0033571", "name": "Rpb5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25167", "map_id": "P25167", "name": "RpIII128", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004463", "map_id": "FBgn0004463", "name": "RpIII128", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432697", "map_id": "none", "name": "TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7JVW5", "map_id": "Q7JVW5", "name": "Dmel\\CG8950", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034186", "map_id": "FBgn0034186", "name": "Dmel\\CG8950", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJY7", "map_id": "Q9VJY7", "name": "FBgn 32517", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032517", "map_id": "FBgn0032517", "name": "FBgn 32517", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VU16", "map_id": "Q9VU16", "name": "CG11008", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260965", "map_id": "FBgn0260965", "name": "CG11008", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIZ2", "map_id": "Q9VIZ2", "name": "l(2)37Cd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086445", "map_id": "FBgn0086445", "name": "l(2)37Cd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JH07", "map_id": "E1JH07", "name": "Dmel\\CG42516", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260390", "map_id": "FBgn0260390", "name": "Dmel\\CG42516", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEL2", "map_id": "Q9VEL2", "name": "Brf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038499", "map_id": "FBgn0038499", "name": "Brf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27896", "map_id": "Q27896", "name": "Trf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010287", "map_id": "FBgn0010287", "name": "Trf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20227", "map_id": "P20227", "name": "Tbp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003687", "map_id": "FBgn0003687", "name": "Tbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQE8", "map_id": "Q9VQE8", "name": "Trf5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031446", "map_id": "FBgn0031446", "name": "Trf5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQE6", "map_id": "Q9VQE6", "name": "Trf4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031444", "map_id": "FBgn0031444", "name": "Trf4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJZ3", "map_id": "Q9VJZ3", "name": "Bdp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032512", "map_id": "FBgn0032512", "name": "Bdp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432759", "map_id": "none", "name": "RNA polymerase III:TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10457699", "map_id": "none", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29804", "map_id": "CHEBI:29103", "name": "K+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_74126", "map_id": "CHEBI:29103", "name": "K+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10457696", "map_id": "none", "name": "GABA B receptor G-protein beta-gamma and Kir3 channel complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B7YZX2", "map_id": "B7YZX2", "name": "Irk3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032706", "map_id": "FBgn0032706", "name": "Irk3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_352011", "map_id": "CHEBI:59888", "name": "GABA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "Q9V3Q9", "map_id": "Q9V3Q9", "name": "GABA-B-R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260446", "map_id": "FBgn0260446", "name": "GABA-B-R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_216283", "map_id": "none", "name": "RDX binds to and ubiquitinates CI", "reversible": "false", "notes": "HIB or Roadkill (RDX) is transcriptionally induced by Hedgehog signalling and binds directly to Cubitus Interruptus (CI), likely in competition with Supressor of Fused (SU(FU)), to link CI with a Cul3 aka guftagu (GFT)-based E3 ubiquitin ligase complex, leading to degradation of active nuclear CI.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_216110", "map_id": "none", "name": "UBI-P63E", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_216104", "map_id": "none", "name": "RDX:GFT:ROC1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VFP2", "map_id": "Q9VFP2", "name": "rdx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "rdx", "map_id": "rdx", "name": "rdx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V475", "map_id": "Q9V475", "name": "GFT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "GFT", "map_id": "GFT", "name": "GFT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NHX0", "map_id": "Q9NHX0", "name": "ROC1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ROC1B", "map_id": "ROC1B", "name": "ROC1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_205911", "map_id": "P19538", "name": "CI", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_216204", "map_id": "none", "name": "RDX:GFT:ROC1B:CI:UBI-P63E", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_216282", "map_id": "none", "name": "Ubiquitinated CI is degraded by the proteasome complex", "reversible": "false", "notes": "The ubiquitinated Cubitus Interruptus (CI) is marked for degradation in the nucleus by the 26S proteasome complex.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_216160", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9Y1A7", "map_id": "Q9Y1A7", "name": "MND", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "MND", "map_id": "MND", "name": "MND", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKZ8", "map_id": "Q9VKZ8", "name": "Usp14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Usp14", "map_id": "Usp14", "name": "Usp14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZ61", "map_id": "Q9XZ61", "name": "Uch-L5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Uch-L5", "map_id": "Uch-L5", "name": "Uch-L5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SYQ2", "map_id": "Q8SYQ2", "name": "I(2)05070", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "I(2)05070", "map_id": "I(2)05070", "name": "I(2)05070", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NHX7", "map_id": "Q9NHX7", "name": "PROSbeta5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PROSbeta5", "map_id": "PROSbeta5", "name": "PROSbeta5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U7A2", "map_id": "Q9U7A2", "name": "RPT4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "RPT4", "map_id": "RPT4", "name": "RPT4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM46", "map_id": "Q9VM46", "name": "CG13779", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CG13779", "map_id": "CG13779", "name": "CG13779", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497363", "map_id": "none", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_9604808", "map_id": "CHEBI:140876", "name": "GlcNAc-\u03b21,3-Gal-R", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_9036984", "map_id": "CHEBI:140162", "name": "Type 1 chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10497360", "map_id": "none", "name": "B3GALTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q24157", "map_id": "Q24157", "name": "brn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000221", "map_id": "FBgn0000221", "name": "brn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439963", "map_id": "none", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191374", "map_id": "CHEBI:15467", "name": "bHMG-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191424", "map_id": "CHEBI:17710", "name": "MVA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439960", "map_id": "none", "name": "HMGCR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P14773", "map_id": "P14773", "name": "Hmgcr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263782", "map_id": "FBgn0263782", "name": "Hmgcr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439993", "map_id": "none", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191403", "map_id": "CHEBI:15899", "name": "MVA5PP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_191362", "map_id": "CHEBI:16584", "name": "IPPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439990", "map_id": "none", "name": "MVD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VXQ3", "map_id": "Q9VXQ3", "name": "Mvd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030683", "map_id": "FBgn0030683", "name": "Mvd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440468", "map_id": "none", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194644", "map_id": "CHEBI:17813", "name": "4,4DMCHtOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_194633", "map_id": "CHEBI:18364", "name": "14DMLANOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10440465", "map_id": "Q8MLV1", "name": "LBR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10487854", "map_id": "none", "name": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191293", "map_id": "CHEBI:15345", "name": "ACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10487851", "map_id": "none", "name": "ACAT2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W0H6", "map_id": "Q9W0H6", "name": "Dmel\\CG9149", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035203", "map_id": "FBgn0035203", "name": "Dmel\\CG9149", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439953", "map_id": "none", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439950", "map_id": "Q7K4Q9", "name": "Hmgs", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0010611", "map_id": "FBgn0010611", "name": "Hmgs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439983", "map_id": "none", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191324", "map_id": "CHEBI:16057", "name": "DMAPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439980", "map_id": "none", "name": "IDI1 or 2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VDC2", "map_id": "Q9VDC2", "name": "Idi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038876", "map_id": "FBgn0038876", "name": "Idi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440463", "map_id": "none", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_194681", "map_id": "CHEBI:17813", "name": "4,4DMCHtOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194725", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194688", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194668", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_194704", "map_id": "CHEBI:18364", "name": "14DMLANOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10439948", "map_id": "none", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191409", "map_id": "CHEBI:17211", "name": "GPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439942", "map_id": "none", "name": "FDPS,GGPS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KN61", "map_id": "Q7KN61", "name": "Fpps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025373", "map_id": "FBgn0025373", "name": "Fpps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS54", "map_id": "Q9VS54", "name": "qm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019662", "map_id": "FBgn0019662", "name": "qm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439945", "map_id": "none", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191385", "map_id": "CHEBI:17407", "name": "FAPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10471177", "map_id": "none", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_193384", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_171095", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10471174", "map_id": "Q8SYH1", "name": "Arv1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0052442", "map_id": "FBgn0052442", "name": "Arv1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493848", "map_id": "none", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191265", "map_id": "CHEBI:15442", "name": "PSQPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8952135", "map_id": "CHEBI:134117", "name": "presqualene monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10493845", "map_id": "Q8T8T9", "name": "Dmel\\CG31717", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0051717", "map_id": "FBgn0051717", "name": "Dmel\\CG31717", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439973", "map_id": "none", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_191296", "map_id": "CHEBI:17436", "name": "MVA5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439970", "map_id": "none", "name": "MVK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K2V9", "map_id": "Q7K2V9", "name": "CG16804", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0061359", "map_id": "FBgn0061359", "name": "CG16804", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440001", "map_id": "none", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439998", "map_id": "Q9VIT2", "name": "PMVK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0032811", "map_id": "FBgn0032811", "name": "PMVK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10429104", "map_id": "none", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10429101", "map_id": "none", "name": "PPA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10458157", "map_id": "none", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458144", "map_id": "none", "name": "hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V9R2", "map_id": "Q9V9R2", "name": "Cul2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032956", "map_id": "FBgn0032956", "name": "Cul2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JWD6", "map_id": "Q7JWD6", "name": "EloC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266711", "map_id": "FBgn0266711", "name": "EloC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3C1", "map_id": "Q9V3C1", "name": "Vhl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041174", "map_id": "FBgn0041174", "name": "Vhl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44226", "map_id": "O44226", "name": "EloB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023212", "map_id": "FBgn0023212", "name": "EloB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24167", "map_id": "Q24167", "name": "sima", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266411", "map_id": "FBgn0266411", "name": "sima", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458150", "map_id": "none", "name": "UBE2D1,2,3:Ubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10437973", "map_id": "none", "name": "Homologues of UBE2D1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10458154", "map_id": "none", "name": "ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458075", "map_id": "none", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458071", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8SX21", "map_id": "Q8SX21", "name": "Hph", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264785", "map_id": "FBgn0264785", "name": "Hph", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_351595", "map_id": "CHEBI:38290", "name": "AscH-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "Q9VY77", "map_id": "Q9VY77", "name": "jub", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030530", "map_id": "FBgn0030530", "name": "jub", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458073", "map_id": "none", "name": "VBC complex (with or without LIMD1)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10458168", "map_id": "none", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458032", "map_id": "Q24167", "name": "sima", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458067", "map_id": "none", "name": "PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10458093", "map_id": "none", "name": "hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10458166", "map_id": "none", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458085", "map_id": "Q24167", "name": "sima", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113671", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113685", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10458134", "map_id": "Q24167", "name": "sima", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159942", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_159939", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10458114", "map_id": "none", "name": "PHD1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458117", "map_id": "none", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458087", "map_id": "Q24167", "name": "sima", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10458104", "map_id": "Q24167", "name": "sima", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10458164", "map_id": "none", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29406", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458079", "map_id": "Q24167", "name": "sima", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458036", "map_id": "Q24167", "name": "sima", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29434", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10458146", "map_id": "none", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458132", "map_id": "Q24167", "name": "sima", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10458142", "map_id": "none", "name": "VHL:EloB,C:CUL2:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458162", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458043", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10458160", "map_id": "none", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458081", "map_id": "Q24167", "name": "sima", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458039", "map_id": "Q24167", "name": "sima", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10458096", "map_id": "none", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458091", "map_id": "none", "name": "UBE2D1,2,3:Ubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10458069", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10427563", "map_id": "none", "name": "Homologues of UBE2D1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479102", "map_id": "none", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696199", "map_id": "CHEBI:15883", "name": "GP4G", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696194", "map_id": "CHEBI:17345", "name": "GMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_113573", "map_id": "CHEBI:15996", "name": "GTP", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10479099", "map_id": "Q4V6M1", "name": "Datp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0051713", "map_id": "FBgn0051713", "name": "Datp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468283", "map_id": "none", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_3299686", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351629", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352327", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10468280", "map_id": "none", "name": "SOD3 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_209799", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "P61851", "map_id": "P61851", "name": "Sod1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003462", "map_id": "FBgn0003462", "name": "Sod1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468411", "map_id": "none", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430996", "map_id": "Q9V429", "name": "Trx-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0040070", "map_id": "FBgn0040070", "name": "Trx-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29408", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430994", "map_id": "Q9V429", "name": "Trx-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10468408", "map_id": "none", "name": "PRDX1,2,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V3P0", "map_id": "Q9V3P0", "name": "Jafrac1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040309", "map_id": "FBgn0040309", "name": "Jafrac1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q960M4", "map_id": "Q960M4", "name": "Prx5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038570", "map_id": "FBgn0038570", "name": "Prx5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUM4", "map_id": "Q9VUM4", "name": "Dmel\\CG6888", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036490", "map_id": "FBgn0036490", "name": "Dmel\\CG6888", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468378", "map_id": "none", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_3341308", "map_id": "CHEBI:18421", "name": "O2-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10436150", "map_id": "none", "name": "Cytochrome c (oxidised)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38574", "map_id": "CHEBI:38574", "name": "CHEBI:38574", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P84029", "map_id": "P84029", "name": "Cyt-c-p", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284248", "map_id": "FBgn0284248", "name": "Cyt-c-p", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436148", "map_id": "none", "name": "Cytochrome c (reduced)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:38573", "map_id": "CHEBI:38573", "name": "CHEBI:38573", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_189461", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10470231", "map_id": "none", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10470229", "map_id": "none", "name": "SOD3 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10468372", "map_id": "none", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10468350", "map_id": "Q9W022", "name": "Dmel\\CG8993", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0035334", "map_id": "FBgn0035334", "name": "Dmel\\CG8993", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1614617", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10468353", "map_id": "Q9W022", "name": "Dmel\\CG8993", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10468369", "map_id": "none", "name": "PRDX3,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VEJ0", "map_id": "Q9VEJ0", "name": "Prx3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038519", "map_id": "FBgn0038519", "name": "Prx3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486317", "map_id": "none", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1222424", "map_id": "CHEBI:18421", "name": "O2.-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486314", "map_id": "A8DWJ8", "name": "Nox", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0085428", "map_id": "FBgn0085428", "name": "Nox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468272", "map_id": "none", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113529", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3299683", "map_id": "CHEBI:18421", "name": "O2.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113533", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10468269", "map_id": "none", "name": "SOD2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q00637", "map_id": "Q00637", "name": "Sod2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010213", "map_id": "FBgn0010213", "name": "Sod2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432650", "map_id": "none", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10432647", "map_id": "none", "name": "CAT tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "P17336", "map_id": "P17336", "name": "Cat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000261", "map_id": "FBgn0000261", "name": "Cat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468778", "map_id": "none", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3697881", "map_id": "CHEBI:25941", "name": "Peroxynitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3697842", "map_id": "CHEBI:16301", "name": "Nitrite", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10468367", "map_id": "Q960M4", "name": "Prx5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10468775", "map_id": "none", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1222481", "map_id": "CHEBI:25941", "name": "Peroxynitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1222379", "map_id": "CHEBI:16301", "name": "Nitrite", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10468406", "map_id": "Q960M4", "name": "Prx5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10468293", "map_id": "none", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468290", "map_id": "none", "name": "2xHC-SOD1:Zn2+:Cu2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431013", "map_id": "none", "name": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431010", "map_id": "none", "name": "TNXRD1:FAD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VNT5", "map_id": "Q9VNT5", "name": "Trxr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037170", "map_id": "FBgn0037170", "name": "Trxr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91938", "map_id": "P91938", "name": "Trxr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020653", "map_id": "FBgn0020653", "name": "Trxr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468833", "map_id": "none", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_163953", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189481", "map_id": "CHEBI:16240", "name": "H2O2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10468830", "map_id": "none", "name": "SOD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "reaction_10461593", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_114520", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_114519", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10461590", "map_id": "none", "name": "PLCbz", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P13217", "map_id": "P13217", "name": "norpA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262738", "map_id": "FBgn0262738", "name": "norpA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461704", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_994170", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_994123", "map_id": "CHEBI:18228", "name": "I(1,3,4)P3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10461569", "map_id": "none", "name": "INPP5(4)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "M9PHS8", "map_id": "M9PHS8", "name": "Dmel\\CG9784", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030761", "map_id": "FBgn0030761", "name": "Dmel\\CG9784", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5U0V7", "map_id": "Q5U0V7", "name": "Synj", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034691", "map_id": "FBgn0034691", "name": "Synj", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46094", "map_id": "O46094", "name": "Ocrl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023508", "map_id": "FBgn0023508", "name": "Ocrl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461652", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10461649", "map_id": "none", "name": "PTEN:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KMQ6", "map_id": "Q7KMQ6", "name": "Pten", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Pten", "map_id": "Pten", "name": "Pten", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461698", "map_id": "none", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2023856", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500596", "map_id": "CHEBI:17815", "name": "DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10461695", "map_id": "none", "name": "PLD4:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VIF2", "map_id": "Q9VIF2", "name": "Pld3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032923", "map_id": "FBgn0032923", "name": "Pld3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIE9", "map_id": "Q9VIE9", "name": "CG9243", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263050", "map_id": "FBgn0263050", "name": "CG9243", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461713", "map_id": "none", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461710", "map_id": "none", "name": "PLCdegh", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10461681", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461676", "map_id": "O46094", "name": "Ocrl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10461472", "map_id": "none", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10461469", "map_id": "none", "name": "ITPKA/B/C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KV26", "map_id": "Q7KV26", "name": "IP3K2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283680", "map_id": "FBgn0283680", "name": "IP3K2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL83", "map_id": "Q9VL83", "name": "IP3K1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032147", "map_id": "FBgn0032147", "name": "IP3K1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465533", "map_id": "none", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446639", "map_id": "Q8INB9", "name": "Akt1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10484665", "map_id": "none", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_449701", "map_id": "CHEBI:15873", "name": "GlcN6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29512", "map_id": "CHEBI:57634", "name": "Fru(6)P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31633", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10484662", "map_id": "none", "name": "GNPDA1,2 hexamers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VMP9", "map_id": "Q9VMP9", "name": "Oscillin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031717", "map_id": "FBgn0031717", "name": "Oscillin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10481369", "map_id": "none", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29800", "map_id": "CHEBI:57604", "name": "1,3BPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6798337", "map_id": "CHEBI:19324", "name": "2,3BPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10481366", "map_id": "none", "name": "BPGM dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VAN7", "map_id": "Q9VAN7", "name": "Pglym78", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014869", "map_id": "FBgn0014869", "name": "Pglym78", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T8W6", "map_id": "Q8T8W6", "name": "Dmel\\CG7059", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038957", "map_id": "FBgn0038957", "name": "Dmel\\CG7059", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGB6", "map_id": "Q9VGB6", "name": "Pglym87", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011270", "map_id": "FBgn0011270", "name": "Pglym87", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10429145", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30533", "map_id": "CHEBI:28602", "name": "D-Fructose 2,6-bisphosphate", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10429142", "map_id": "none", "name": "PFKFB dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VWH7", "map_id": "Q9VWH7", "name": "Pfrx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027621", "map_id": "FBgn0027621", "name": "Pfrx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427841", "map_id": "none", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427838", "map_id": "none", "name": "phosphoPFKFB1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10428045", "map_id": "none", "name": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30537", "map_id": "CHEBI:58225", "name": "G6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428042", "map_id": "none", "name": "GPI dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P52029", "map_id": "P52029", "name": "Pgi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003074", "map_id": "FBgn0003074", "name": "Pgi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428013", "map_id": "none", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75970", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29578", "map_id": "CHEBI:59776", "name": "GA3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428010", "map_id": "none", "name": "TPI1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P29613", "map_id": "P29613", "name": "Tpi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086355", "map_id": "FBgn0086355", "name": "Tpi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10429003", "map_id": "none", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30485", "map_id": "CHEBI:58289", "name": "2PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29492", "map_id": "CHEBI:58702", "name": "PEP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428103", "map_id": "none", "name": "enolase dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P15007", "map_id": "P15007", "name": "Eno", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000579", "map_id": "FBgn0000579", "name": "Eno", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10429001", "map_id": "none", "name": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29728", "map_id": "CHEBI:58272", "name": "3PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428883", "map_id": "none", "name": "PGAM dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10428902", "map_id": "none", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30014", "map_id": "CHEBI:32966", "name": "F1,6PP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428897", "map_id": "none", "name": "aldolase tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VBF5", "map_id": "Q9VBF5", "name": "Ald2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039425", "map_id": "FBgn0039425", "name": "Ald2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07764", "map_id": "P07764", "name": "Ald1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000064", "map_id": "FBgn0000064", "name": "Ald1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427973", "map_id": "none", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_70113", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10427970", "map_id": "none", "name": "glucokinase and hexokinases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7JYW9", "map_id": "Q7JYW9", "name": "Hex-C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001187", "map_id": "FBgn0001187", "name": "Hex-C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W330", "map_id": "Q9W330", "name": "Hex-A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001186", "map_id": "FBgn0001186", "name": "Hex-A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NFT9", "map_id": "Q9NFT9", "name": "Hex-t1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042711", "map_id": "FBgn0042711", "name": "Hex-t1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NFT7", "map_id": "Q9NFT7", "name": "Hex-t2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042710", "map_id": "FBgn0042710", "name": "Hex-t2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10429157", "map_id": "none", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428087", "map_id": "none", "name": "PGK complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q01604", "map_id": "Q01604", "name": "Pgk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250906", "map_id": "FBgn0250906", "name": "Pgk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495131", "map_id": "none", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955759", "map_id": "CHEBI:18148", "name": "G1,6BP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10427859", "map_id": "none", "name": "PGM2L1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1Z9V3", "map_id": "A1Z9V3", "name": "Pgm2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033969", "map_id": "FBgn0033969", "name": "Pgm2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7P1", "map_id": "A1Z7P1", "name": "Pgm2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033377", "map_id": "FBgn0033377", "name": "Pgm2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428035", "map_id": "none", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428032", "map_id": "none", "name": "PFK tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P52034", "map_id": "P52034", "name": "Pfk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003071", "map_id": "FBgn0003071", "name": "Pfk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_76190", "map_id": "CHEBI:30769", "name": "CIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10428003", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428000", "map_id": "none", "name": "GAPDH tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P07486", "map_id": "P07486", "name": "Gapdh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001091", "map_id": "FBgn0001091", "name": "Gapdh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JY07", "map_id": "Q7JY07", "name": "anon-WO0140519.132", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034173", "map_id": "FBgn0034173", "name": "anon-WO0140519.132", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07487", "map_id": "P07487", "name": "Gapdh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001092", "map_id": "FBgn0001092", "name": "Gapdh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10429058", "map_id": "none", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29398", "map_id": "CHEBI:15361", "name": "PYR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10429055", "map_id": "none", "name": "pyruvate kinase tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VNZ9", "map_id": "Q9VNZ9", "name": "Dmel\\CG11249", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037115", "map_id": "FBgn0037115", "name": "Dmel\\CG11249", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFG4", "map_id": "Q9VFG4", "name": "Dmel\\CG7362", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038258", "map_id": "FBgn0038258", "name": "Dmel\\CG7362", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVH0", "map_id": "Q9VVH0", "name": "Dmel\\CG12229", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036723", "map_id": "FBgn0036723", "name": "Dmel\\CG12229", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VD23", "map_id": "Q9VD23", "name": "Dmel\\CG7069", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038952", "map_id": "FBgn0038952", "name": "Dmel\\CG7069", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQH0", "map_id": "Q9VQH0", "name": "Dmel\\CG2964", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031462", "map_id": "FBgn0031462", "name": "Dmel\\CG2964", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62619", "map_id": "O62619", "name": "PyK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267385", "map_id": "FBgn0267385", "name": "PyK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10437795", "map_id": "none", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10437793", "map_id": "none", "name": "Homologues of GCK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427948", "map_id": "none", "name": "Homologues of GCK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10453164", "map_id": "none", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532562", "map_id": "CHEBI:17369", "name": "Man6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453161", "map_id": "Q9VH77", "name": "Mpi", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0286506", "map_id": "FBgn0286506", "name": "Mpi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450486", "map_id": "none", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_532531", "map_id": "CHEBI:35374", "name": "Man1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10450481", "map_id": "Q9VTZ6", "name": "Pmm2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036300", "map_id": "FBgn0036300", "name": "Pmm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10447638", "map_id": "none", "name": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447632", "map_id": "none", "name": "Beta-catenin/gamma catenin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10442033", "map_id": "Q9VJB6", "name": "CadN2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10447634", "map_id": "Q7PLI0", "name": "p120ctn", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10447624", "map_id": "none", "name": "Homologues of CTNNA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447636", "map_id": "none", "name": "Cadherin:Catenin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447616", "map_id": "none", "name": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_140648", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10447614", "map_id": "none", "name": "Cadherin trans-homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "reaction_10449511", "map_id": "none", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10443378", "map_id": "none", "name": "Integrin alpha6beta4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W1M8", "map_id": "Q9W1M8", "name": "ItgaPS5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034880", "map_id": "FBgn0034880", "name": "ItgaPS5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V7A4", "map_id": "Q9V7A4", "name": "ItgaPS4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034005", "map_id": "FBgn0034005", "name": "ItgaPS4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24247", "map_id": "Q24247", "name": "mew", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004456", "map_id": "FBgn0004456", "name": "mew", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O44386", "map_id": "O44386", "name": "scb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286785", "map_id": "FBgn0286785", "name": "scb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27591", "map_id": "Q27591", "name": "Itgbn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010395", "map_id": "FBgn0010395", "name": "Itgbn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P11584", "map_id": "P11584", "name": "mys", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004657", "map_id": "FBgn0004657", "name": "mys", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441643", "map_id": "A1Z9J3", "name": "shot", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449509", "map_id": "none", "name": "Integrin alpha 6:beta 4:Plectin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449527", "map_id": "none", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10449523", "map_id": "none", "name": "BP230", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10449519", "map_id": "none", "name": "Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W4Y3", "map_id": "Q9W4Y3", "name": "trol", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284408", "map_id": "FBgn0284408", "name": "trol", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P15215", "map_id": "P15215", "name": "phospho-LanB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267348", "map_id": "FBgn0267348", "name": "phospho-LanB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IP51", "map_id": "Q8IP51", "name": "wb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261563", "map_id": "FBgn0261563", "name": "wb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q00174", "map_id": "Q00174", "name": "LanA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002526", "map_id": "FBgn0002526", "name": "LanA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449525", "map_id": "none", "name": "BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450422", "map_id": "none", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443411", "map_id": "none", "name": "Laminin-332", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10450420", "map_id": "none", "name": "Integrin alpha6:beta4:Plectin:BP180 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450418", "map_id": "none", "name": "CD151 interacts with BP180 and the integrin alpha 6 subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450414", "map_id": "Q8IQK9", "name": "Tsp68C", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0043550", "map_id": "FBgn0043550", "name": "Tsp68C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450416", "map_id": "none", "name": "CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8IQK9", "map_id": "Q8IQK9", "name": "Tsp68C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449180", "map_id": "none", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449176", "map_id": "none", "name": "Homologues of FERMT2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VZI3", "map_id": "Q9VZI3", "name": "Fit1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035498", "map_id": "FBgn0035498", "name": "Fit1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVD2", "map_id": "Q9VVD2", "name": "Fit2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036688", "map_id": "FBgn0036688", "name": "Fit2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449164", "map_id": "Q9N675", "name": "Zyx", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0011642", "map_id": "FBgn0011642", "name": "Zyx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449178", "map_id": "none", "name": "MIG-2:MIGFILIN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9N675", "map_id": "Q9N675", "name": "Zyx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450586", "map_id": "none", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450580", "map_id": "none", "name": "PINCH", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10450582", "map_id": "none", "name": "alpha/beta parvin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449503", "map_id": "Q9V400", "name": "Ilk", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0028427", "map_id": "FBgn0028427", "name": "Ilk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450584", "map_id": "none", "name": "PINCH-ILK-parvin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V400", "map_id": "Q9V400", "name": "Ilk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8INQ9", "map_id": "Q8INQ9", "name": "stck", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020249", "map_id": "FBgn0020249", "name": "stck", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449507", "map_id": "none", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441029", "map_id": "P11584", "name": "mys", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10449505", "map_id": "none", "name": "ILK:Integrin beta-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450563", "map_id": "none", "name": "PARVA associates with Paxillin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450559", "map_id": "Q9VWD0", "name": "parvin", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0052528", "map_id": "FBgn0052528", "name": "parvin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438879", "map_id": "Q2PDT4", "name": "Pax", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0041789", "map_id": "FBgn0041789", "name": "phospho-Pax", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450561", "map_id": "none", "name": "PARVA:Paxillin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VWD0", "map_id": "Q9VWD0", "name": "parvin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2PDT4", "map_id": "Q2PDT4", "name": "phospho-Pax", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450567", "map_id": "none", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448617", "map_id": "Q8T4F7", "name": "ena", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10450565", "map_id": "none", "name": "MIGFILIN:VASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T4F7", "map_id": "Q8T4F7", "name": "ena", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ena", "map_id": "ena", "name": "ena", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449188", "map_id": "none", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449131", "map_id": "Q9VEN1", "name": "cher", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0014141", "map_id": "FBgn0014141", "name": "phospho-cher", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449186", "map_id": "none", "name": "Migfilin:Filamin A:F-actin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VEN1", "map_id": "Q9VEN1", "name": "phospho-cher", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449515", "map_id": "none", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449141", "map_id": "Q9VWD0", "name": "parvin", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442520", "map_id": "A8DZ19", "name": "RtGEF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449513", "map_id": "none", "name": "ParvB/Affixin:Alpha-Pix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10449145", "map_id": "none", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449136", "map_id": "P18091", "name": "Actn", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449143", "map_id": "none", "name": "PARVB:alpha actinin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10449159", "map_id": "none", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449155", "map_id": "Q8INQ9", "name": "stck", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449150", "map_id": "Q9V428", "name": "ics", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0028546", "map_id": "FBgn0028546", "name": "ics", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449157", "map_id": "none", "name": "Rsu-1:Pinch1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V428", "map_id": "Q9V428", "name": "ics", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450576", "map_id": "none", "name": "Association of PARVA with TESK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450572", "map_id": "Q9VE06", "name": "cdi", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0004876", "map_id": "FBgn0004876", "name": "cdi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450574", "map_id": "none", "name": "PARVA:TESK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VE06", "map_id": "Q9VE06", "name": "cdi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444555", "map_id": "none", "name": "Nephrin trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444454", "map_id": "Q0E9F2", "name": "sns", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0024189", "map_id": "FBgn0024189", "name": "phospho-sns", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444456", "map_id": "none", "name": "NPHS1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q0E9F2", "map_id": "Q0E9F2", "name": "phospho-sns", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10451625", "map_id": "none", "name": "Heterodimerization of nephrin and KIRREL2, KIRREL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10451621", "map_id": "none", "name": "KIRREL2, KIRREL3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W4T9", "map_id": "Q9W4T9", "name": "kirre", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028369", "map_id": "FBgn0028369", "name": "kirre", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQW7", "map_id": "Q9VQW7", "name": "ed", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000547", "map_id": "FBgn0000547", "name": "ed", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q08180", "map_id": "Q08180", "name": "rst", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003285", "map_id": "FBgn0003285", "name": "rst", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A023GPK8", "map_id": "A0A023GPK8", "name": "fred", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051774", "map_id": "FBgn0051774", "name": "fred", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10451623", "map_id": "none", "name": "NPHS1 dimer:KIRREL2,KIRREL3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495542", "map_id": "none", "name": "Nephrin dimer:KIRREL binds FYN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444480", "map_id": "none", "name": "NPHS1 dimer:KIRREL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444577", "map_id": "none", "name": "NPHS1 dimer:KIRREL:FYN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444566", "map_id": "none", "name": "Nephrin interacts with Podocin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444528", "map_id": "none", "name": "p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444562", "map_id": "none", "name": "Podocin oligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VZA4", "map_id": "Q9VZA4", "name": "STOML3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260657", "map_id": "FBgn0260657", "name": "STOML3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444564", "map_id": "none", "name": "Podocin:p-Nephrin:Fyn:NEPH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444580", "map_id": "none", "name": "Phosphorylation of nephrin by FYN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10444532", "map_id": "none", "name": "Nephrin binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444530", "map_id": "none", "name": "NEPH1:p-Nephrin:Fyn:NCK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444482", "map_id": "none", "name": "Cis-Heterodimerization of nephrin and KIRREL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444478", "map_id": "none", "name": "Homologues of KIRREL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10484751", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10484729", "map_id": "none", "name": "ETF1 dimer:eRF3:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VPH7", "map_id": "Q9VPH7", "name": "eRF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036974", "map_id": "FBgn0036974", "name": "eRF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK85", "map_id": "Q9VK85", "name": "eRF3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020443", "map_id": "FBgn0020443", "name": "eRF3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484736", "map_id": "none", "name": "Me-Q185-ETF1 dimer:eRF3:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10484748", "map_id": "none", "name": "N6AMT1:TRMT112", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VP65", "map_id": "Q9VP65", "name": "TRMT112", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037061", "map_id": "FBgn0037061", "name": "TRMT112", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQF8", "map_id": "Q9VQF8", "name": "HemK2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031454", "map_id": "FBgn0031454", "name": "HemK2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469966", "map_id": "none", "name": "SMURF1/2 are recruited to the DVL2:PARD6A complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469940", "map_id": "none", "name": "PARD6A:pp-DVL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10469961", "map_id": "none", "name": "PARD6A:pp-DVL2:SMURF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469964", "map_id": "none", "name": "SMURF1/2 ubiquitinates PRICKLE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469951", "map_id": "none", "name": "Homologues of PRICKLE1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U1I1", "map_id": "Q9U1I1", "name": "esn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263934", "map_id": "FBgn0263934", "name": "esn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6W3", "map_id": "A1Z6W3", "name": "PK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PK", "map_id": "PK", "name": "PK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469959", "map_id": "none", "name": "Homologues of ub-PRICKLE1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10470337", "map_id": "none", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10470333", "map_id": "none", "name": "WNT5A-binding FZDs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10468078", "map_id": "P28466", "name": "Wnt5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10470335", "map_id": "none", "name": "WNT5A:FZD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469968", "map_id": "none", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10456021", "map_id": "none", "name": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_727815", "map_id": "CHEBI:16556", "name": "CMP-Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10454862", "map_id": "none", "name": "Core 1 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q9VU94", "map_id": "Q9VU94", "name": "Hml", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029167", "map_id": "FBgn0029167", "name": "Hml", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0KHY3", "map_id": "Q0KHY3", "name": "mesh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051004", "map_id": "FBgn0051004", "name": "mesh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z877", "map_id": "A1Z877", "name": "Ndg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026403", "map_id": "FBgn0026403", "name": "Ndg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10456019", "map_id": "none", "name": "Sialyl-2,6 T antigens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_727810", "map_id": "CHEBI:17361", "name": "CMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10455823", "map_id": "Q9GU23", "name": "SiaT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0035050", "map_id": "FBgn0035050", "name": "SiaT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10456000", "map_id": "none", "name": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10454561", "map_id": "none", "name": "Tn antigens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10455998", "map_id": "none", "name": "Sialyl Tn antigens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10463326", "map_id": "none", "name": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10444709", "map_id": "none", "name": "Homologues of AGT(34-41)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VPH9", "map_id": "Q9VPH9", "name": "Spn77Bc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036970", "map_id": "FBgn0036970", "name": "Spn77Bc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLZ8", "map_id": "Q9VLZ8", "name": "Spn28B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": 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}, { "id": "Q9VLQ7", "map_id": "Q9VLQ7", "name": "Spn28F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028987", "map_id": "FBgn0028987", "name": "Spn28F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL44", "map_id": "Q9VL44", "name": "Spn31A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032178", "map_id": "FBgn0032178", "name": "Spn31A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VII7", "map_id": "Q9VII7", "name": "Spn38F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028986", "map_id": 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"compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028988", "map_id": "FBgn0028988", "name": "Spn42Dd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KA66", "map_id": "Q7KA66", "name": "Spn43Aa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024294", "map_id": "FBgn0024294", "name": "Spn43Aa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K8Y5", "map_id": "Q7K8Y5", "name": "Spn42Da", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265137", "map_id": "FBgn0265137", "name": "Spn42Da", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", 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"Spn28Da", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051902", "map_id": "FBgn0051902", "name": "Spn28Da", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E8C8", "map_id": "Q0E8C8", "name": "Spn77Ba", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262057", "map_id": "FBgn0262057", "name": "Spn77Ba", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6V5", "map_id": "A1Z6V5", "name": "Spn43Ab", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024293", "map_id": "FBgn0024293", "name": "Spn43Ab", "type": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_188972", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10463464", "map_id": "none", "name": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10463461", "map_id": "none", "name": "Renin:Prorenin Receptor", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VHG4", "map_id": "Q9VHG4", "name": "ATP6AP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037671", "map_id": "FBgn0037671", "name": "ATP6AP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464744", "map_id": "none", "name": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10464741", "map_id": "none", "name": "Prorenin-Prorenin Receptor", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10464712", "map_id": "none", "name": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10463237", "map_id": "none", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10463133", "map_id": "Q9W5Y0", "name": "Nep3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0031081", "map_id": "FBgn0031081", "name": "Nep3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10463235", "map_id": "none", "name": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10463230", "map_id": "none", "name": "Homologues of ACE2(18-805)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10463233", "map_id": "none", "name": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10464257", "map_id": "none", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10464254", "map_id": "none", "name": "Carboxypeptidase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q961J8", "map_id": "Q961J8", "name": "Dmel\\CG8560", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035781", "map_id": "FBgn0035781", "name": "Dmel\\CG8560", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRZ3", "map_id": "Q9VRZ3", "name": "Dmel\\CG14820", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035718", "map_id": "FBgn0035718", "name": "Dmel\\CG14820", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX86", "map_id": "Q9VX86", "name": "Cg8945", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030815", "map_id": "FBgn0030815", "name": "Cg8945", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JYV3", "map_id": "Q7JYV3", "name": "anon-WO0140519.63", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033774", "map_id": "FBgn0033774", "name": "anon-WO0140519.63", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLZ2", "map_id": "Q9VLZ2", "name": "Dmel\\CG18585", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031929", "map_id": "FBgn0031929", "name": "Dmel\\CG18585", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS80", "map_id": "Q9VS80", "name": "Dmel\\CG8539", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035791", "map_id": "FBgn0035791", "name": "Dmel\\CG8539", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E9F9", "map_id": "Q0E9F9", "name": "Dmel\\CG2915", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033241", "map_id": "FBgn0033241", "name": "Dmel\\CG2915", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLZ1", "map_id": "Q9VLZ1", "name": "Dmel\\CG7025", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031930", "map_id": "FBgn0031930", "name": "Dmel\\CG7025", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS67", "map_id": "Q9VS67", "name": "carboxypeptidase b1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035780", "map_id": "FBgn0035780", "name": "carboxypeptidase b1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PEV1", "map_id": "M9PEV1", "name": "Dmel\\CG8564", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035776", "map_id": "FBgn0035776", "name": "Dmel\\CG8564", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL87", "map_id": "Q9VL87", "name": "Dmel\\CG4017", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032143", "map_id": "FBgn0032143", "name": "Dmel\\CG4017", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS66", "map_id": "Q9VS66", "name": "Dmel\\CG8562", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035779", "map_id": "FBgn0035779", "name": "Dmel\\CG8562", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W478", "map_id": "Q9W478", "name": "Dmel\\CG3097", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029804", "map_id": "FBgn0029804", "name": "Dmel\\CG3097", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL86", "map_id": "Q9VL86", "name": "CPB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032144", "map_id": "FBgn0032144", "name": "CPB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS65", "map_id": "Q9VS65", "name": "CG18415", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052379", "map_id": "FBgn0052379", "name": "CG18415", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W477", "map_id": "Q9W477", "name": "CG15768", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259149", "map_id": "FBgn0259149", "name": "CG15768", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCM8", "map_id": "Q9VCM8", "name": "Dmel\\CG4408", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039073", "map_id": "FBgn0039073", "name": "Dmel\\CG4408", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS64", "map_id": "Q9VS64", "name": "Dmel\\CG8563", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035777", "map_id": "FBgn0035777", "name": "Dmel\\CG8563", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W475", "map_id": "Q9W475", "name": "Dmel\\CG3108", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029807", "map_id": "FBgn0029807", "name": "Dmel\\CG3108", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10463136", "map_id": "none", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_209224", "map_id": "none", "name": "SLMB binds to and ubiquitinates phosphorylated CI", "reversible": "false", "notes": "Phosphorylated Cubitus Interruptus (CI) is now recognised by Slimb (SLMB), which is part of the SCF (Skp1, Cdc53, and F-box) ubiquitin ligase complex. CI associates with SLMB via its phosphorylated residues and is then ubiquitinated by the SCF ubiquitin ligase complex.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206204", "map_id": "none", "name": "UBI-P63E", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206766", "map_id": "none", "name": "COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O76324", "map_id": "O76324", "name": "DCO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DCO", "map_id": "DCO", "name": "DCO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P23647", "map_id": "P23647", "name": "Phospho FU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho FU", "map_id": "Phospho FU", "name": "Phospho FU", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16844", "map_id": "O16844", "name": "Phospho (2 sites) COS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho (2 sites) COS", "map_id": "Phospho (2 sites) COS", "name": "Phospho (2 sites) COS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_206788", "map_id": "none", "name": "SLMB:SKPA:LIN19:ROC1A:EFF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O44382", "map_id": "O44382", "name": "SLMB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "SLMB", "map_id": "SLMB", "name": "SLMB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_207011", "map_id": "none", "name": "SLMB:SKPA:LIN19:ROC1A:EFF:COS:Phospho (16 sites) CI:UBI-P63E:FU:PKA-C1:SGG:CKIalpha:DCO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_207002", "map_id": "none", "name": "SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P91667", "map_id": "P91667", "name": "Phospho (5 sites) APC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho (5 sites) APC", "map_id": "Phospho (5 sites) APC", "name": "Phospho (5 sites) APC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_209278", "map_id": "none", "name": "Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex", "reversible": "false", "notes": "Ubiquitinated and phosphorylated Cubitus Interruptus (CI) is processed by the proteasome complex resulting in a truncated product, CI75, with a C-terminus somewhere between residues 650-700 (Aza-Blanc et al., 1997) or 611-760 (Methot and Basler, 1999). It is thought that the zinc-finger domain and C-terminal simple sequences arrest proteasome digestion from the C-terminus. Some CI is likely to be fully proteolysed by the proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206171", "map_id": "P19538", "name": "CI75", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206900", "map_id": "none", "name": "COS:FU:PKA-C1:SGG:CKIalpha:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206968", "map_id": "none", "name": "26S proteasome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475099", "map_id": "none", "name": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475094", "map_id": "none", "name": "Activated FGFR3:pY-SHC1:GRB2:SOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475096", "map_id": "none", "name": "Activated FGFR3:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475085", "map_id": "none", "name": "Activated FGFR3:pY-SHC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475073", "map_id": "none", "name": "Activated FGFR3 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465477", "map_id": "none", "name": "Activated FGFR3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475071", "map_id": "none", "name": "Activated FGFR3:SHC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475088", "map_id": "none", "name": "Activated FGFR3 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475069", "map_id": "none", "name": "Activated FGFR3 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475067", "map_id": "none", "name": "Activated FGFR3:FRS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474925", "map_id": "none", "name": "Activated FGFR3 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474920", "map_id": "none", "name": "Activated FGFR3:FRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10465479", "map_id": "none", "name": "Activated FGFR3:p-FRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474923", "map_id": "none", "name": "Activated FGFR3:p-8T-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474939", "map_id": "none", "name": "Activated FGFR3:pFRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474932", "map_id": "none", "name": "Activated FGFR3:p-FRS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474934", "map_id": "none", "name": "Activated FGFR3:p-FRS:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475083", "map_id": "none", "name": "Activated FGFR3 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475078", "map_id": "none", "name": "Activated FGFR3:p-FRS:PTPN11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475080", "map_id": "none", "name": "Activated FGFR3:p-FRS:p-PTPN11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474937", "map_id": "none", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10493208", "map_id": "none", "name": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475076", "map_id": "none", "name": "Activated FGFR3 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474930", "map_id": "none", "name": "Activated FGFR3:p-FRS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474928", "map_id": "none", "name": "Activated FGFR3 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474855", "map_id": "none", "name": "Activated FGFR3 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474850", "map_id": "none", "name": "activated FGFR3:PLCG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474822", "map_id": "none", "name": "p-4Y-PLCG1 dissociates from activated FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474820", "map_id": "none", "name": "activated FGFR3:p-4Y-PLCG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474853", "map_id": "none", "name": "Activated FGFR3 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475180", "map_id": "none", "name": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465509", "map_id": "none", "name": "Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475177", "map_id": "none", "name": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465483", "map_id": "none", "name": "Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475092", "map_id": "none", "name": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465505", "map_id": "none", "name": "Activated FGFR3:p-FRS2:p-PTPN11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10465507", "map_id": "none", "name": "Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475090", "map_id": "none", "name": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465481", "map_id": "none", "name": "Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10488437", "map_id": "none", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_735700", "map_id": "CHEBI:16650", "name": "UDP-GalNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10488432", "map_id": "Q9VDT9", "name": "bnl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10488434", "map_id": "Q9VDT9", "name": "bnl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10454602", "map_id": "Q6WV20", "name": "Pgant1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0034025", "map_id": "FBgn0034025", "name": "Pgant1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488439", "map_id": "none", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10433476", "map_id": "Q9VDT9", "name": "bnl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10439768", "map_id": "none", "name": "Autocatalytic phosphorylation of FGFR3c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439729", "map_id": "none", "name": "FGFR3c homodimer bound to FGF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10433592", "map_id": "none", "name": "Activated FGFR3c homodimer ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439731", "map_id": "none", "name": "FGFR3c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10439725", "map_id": "none", "name": "Homologues of FGFR3c", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439743", "map_id": "none", "name": "FGFR3b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10439737", "map_id": "none", "name": "Homologues of FGFR3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10433471", "map_id": "Q9VDT9", "name": "bnl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10439741", "map_id": "none", "name": "FGFR3b homodimer bound to FGF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439765", "map_id": "none", "name": "Autocatalytic phosphorylation of FGFR3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10433573", "map_id": "none", "name": "Activated FGFR3b homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474991", "map_id": "none", "name": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475192", "map_id": "none", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475150", "map_id": "none", "name": "Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475155", "map_id": "none", "name": "CBL ubiquitinates FRS2 and FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475152", "map_id": "none", "name": "Ub-Activated FGFR3 complex:Ub-p-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439771", "map_id": "none", "name": "Autocatalytic phosphorylation of FGFR2b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439717", "map_id": "none", "name": "FGFR2b homodimer bound to FGF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10433531", "map_id": "none", "name": "Activated FGFR2b homodimer bound to FGF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439719", "map_id": "none", "name": "FGFR2b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10433429", "map_id": "Q9VDT9", "name": "bnl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10439670", "map_id": "Q09147", "name": "btl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10439774", "map_id": "none", "name": "Autocatalytic phosphorylation of FGFR2c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439703", "map_id": "none", "name": "FGFR2c homodimer bound to FGF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10433553", "map_id": "none", "name": "Activated FGFR2c homodimer bound to FGF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439705", "map_id": "none", "name": "FGFR2c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439691", "map_id": "Q09147", "name": "btl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10475065", "map_id": "none", "name": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10465499", "map_id": "none", "name": "Activated FGFR2:p-FRS2:p-PTPN11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10465501", "map_id": "none", "name": "Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475174", "map_id": "none", "name": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465475", "map_id": "none", "name": "Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475171", "map_id": "none", "name": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465503", "map_id": "none", "name": "Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475056", "map_id": "none", "name": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10465471", "map_id": "none", "name": "Activated FGFR2:p-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10465473", "map_id": "none", "name": "Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475054", "map_id": "none", "name": "Activated FGFR2 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475049", "map_id": "none", "name": "Activated FGFR2:p-FRS:PTPN11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475051", "map_id": "none", "name": "Activated FGFR2:p-FRS:p-PTPN11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474893", "map_id": "none", "name": "Activated FGFR2 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465469", "map_id": "none", "name": "Activated FGFR2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474875", "map_id": "none", "name": "Activated FGFR2:FRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10493202", "map_id": "none", "name": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474890", "map_id": "none", "name": "Activated FGFR2 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474888", "map_id": "none", "name": "Activated FGFR2:p-8T-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475063", "map_id": "none", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475058", "map_id": "none", "name": "Activated FGFR2:p-FRS:GRB2:SOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475060", "map_id": "none", "name": "Activated FGFR2:pFRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475047", "map_id": "none", "name": "Activated FGFR2:p-FRS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474907", "map_id": "none", "name": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474904", "map_id": "none", "name": "Activated FGFR2:pY-SHC1:GRB2:SOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474918", "map_id": "none", "name": "Activated FGFR2 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474911", "map_id": "none", "name": "Activated FGFR2:SHC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474902", "map_id": "none", "name": "Activated FGFR2:pY-SHC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474915", "map_id": "none", "name": "Activated FGFR2:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10474913", "map_id": "none", "name": "Activated FGFR2 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474840", "map_id": "none", "name": "Activated FGFR2 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474813", "map_id": "none", "name": "activated FGFR2:PLCG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474838", "map_id": "none", "name": "p-4Y-PLCG1 dissociates from activated FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474815", "map_id": "none", "name": "activated FGFR2:p-4Y-PLCG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474818", "map_id": "none", "name": "Activated FGFR2 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474989", "map_id": "none", "name": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475148", "map_id": "none", "name": "CBL ubiquitinates FRS2 and FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475143", "map_id": "none", "name": "Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475145", "map_id": "none", "name": "Ub-Activated FGFR2 complex:Ub-p-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475190", "map_id": "none", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10485933", "map_id": "none", "name": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10485901", "map_id": "none", "name": "hnRNPH1:hnPNPF:RBFOX2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VGH5", "map_id": "Q9VGH5", "name": "glo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259139", "map_id": "FBgn0259139", "name": "glo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0D6", "map_id": "Q9W0D6", "name": "cg7879", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035235", "map_id": "FBgn0035235", "name": "cg7879", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9NFQ7", "map_id": "M9NFQ7", "name": "Rbfox1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052062", "map_id": "FBgn0052062", "name": "Rbfox1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485929", "map_id": "Q9BJZ5", "name": "fus", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0023441", "map_id": "FBgn0023441", "name": "fus", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485927", "map_id": "Q9BJZ5", "name": "fus", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10485894", "map_id": "none", "name": "capped, methylated pre-FGFR2 mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P41900", "map_id": "P41900", "name": "TfIIFbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010421", "map_id": "FBgn0010421", "name": "TfIIFbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q05913", "map_id": "Q05913", "name": "TfIIFalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010282", "map_id": "FBgn0010282", "name": "TfIIFalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJE4", "map_id": "Q9VJE4", "name": "Rpb11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032634", "map_id": "FBgn0032634", "name": "Rpb11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEA5", "map_id": "Q9VEA5", "name": "Rpb4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263757", "map_id": "FBgn0263757", "name": "Rpb4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P08266", "map_id": "P08266", "name": "RpII140", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262955", "map_id": "FBgn0262955", "name": "RpII140", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O97183", "map_id": "O97183", "name": "Rpb3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026373", "map_id": "FBgn0026373", "name": "Rpb3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P04052", "map_id": "P04052", "name": "phospho-RpII215", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003277", "map_id": "FBgn0003277", "name": "phospho-RpII215", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36958", "map_id": "P36958", "name": "RpII15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004855", "map_id": "FBgn0004855", "name": "RpII15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFB5", "map_id": "Q9VFB5", "name": "Rpb7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051155", "map_id": "FBgn0051155", "name": "Rpb7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10429340", "map_id": "Q9VHC7", "name": "rump", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0267790", "map_id": "FBgn0267790", "name": "rump", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485922", "map_id": "none", "name": "TIA1/TIAL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A8JPX0", "map_id": "A8JPX0", "name": "CG12852", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085383", "map_id": "FBgn0085383", "name": "CG12852", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JIZ9", "map_id": "E1JIZ9", "name": "trv", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085391", "map_id": "FBgn0085391", "name": "trv", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IMX4", "map_id": "Q8IMX4", "name": "Rox8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005649", "map_id": "FBgn0005649", "name": "Rox8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485931", "map_id": "none", "name": "FGFR2 IIIb-specific splicing complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VHC7", "map_id": "Q9VHC7", "name": "rump", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BJZ5", "map_id": "Q9BJZ5", "name": "fus", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474976", "map_id": "none", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474972", "map_id": "none", "name": "FGFRL1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9I7U4", "map_id": "Q9I7U4", "name": "sls", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086906", "map_id": "FBgn0086906", "name": "sls", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474974", "map_id": "none", "name": "FGFRL1-binding FGFs:FGFRL1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474987", "map_id": "none", "name": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474982", "map_id": "none", "name": "Activated FGFR1:FRS2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474984", "map_id": "none", "name": "Activated FGFR1:p-8T-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475141", "map_id": "none", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465493", "map_id": "none", "name": "Activated FGFR1:p-FRS2:p-PTPN11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475134", "map_id": "none", "name": "Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475139", "map_id": "none", "name": "CBL ubiquitinates FRS2 and FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475136", "map_id": "none", "name": "Ub-Activated FGFR1 complex:Ub-p-FRS2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474978", "map_id": "none", "name": "KAL1 binds FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439681", "map_id": "Q9VCC7", "name": "Kal1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "FBgn0039155", "map_id": "FBgn0039155", "name": "Kal1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10439672", "map_id": "none", "name": "Homologues of FGFR1c", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439683", "map_id": "none", "name": "FGFR1c:KAL1", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VCC7", "map_id": "Q9VCC7", "name": "Kal1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439666", "map_id": "none", "name": "FGFR1b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10439660", "map_id": "none", "name": "Homologues of FGFR1b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439664", "map_id": "none", "name": "FGFR1b homodimer bound to FGF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439777", "map_id": "none", "name": "Autocatalytic phosphorylation of FGFR1b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10433465", "map_id": "none", "name": "Activated FGFR1b homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439687", "map_id": "none", "name": "FGFR1c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10439676", "map_id": "none", "name": "FGFR1c homodimer bound to FGF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439685", "map_id": "none", "name": "KAL1:HS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10439780", "map_id": "none", "name": "Autocatalytic phosphorylation of FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10433484", "map_id": "none", "name": "Activated FGFR1c homodimer ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474980", "map_id": "none", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10439759", "map_id": "none", "name": "FGFR1c binds to Klotho-bound FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10433503", "map_id": "none", "name": "Klotho bound to FGF23", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439757", "map_id": "none", "name": "FGF23 bound to Klotho and FGFR1c", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439920", "map_id": "none", "name": "Autocatalytic phosphorylation of Klotho-bound FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10433505", "map_id": "none", "name": "Activated FGFR1c bound to FGF23:Klotho", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474846", "map_id": "none", "name": "Activated FGFR1 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474824", "map_id": "none", "name": "activated FGFR1:PLCG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474829", "map_id": "none", "name": "Activated FGFR1 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474826", "map_id": "none", "name": "activated FGFR1:p-4Y-PLCG1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474844", "map_id": "none", "name": "p-4Y-PLCG1 dissociates from activated FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10475309", "map_id": "none", "name": "Activated FGFR1 binds FLRT1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475301", "map_id": "M9MSI4", "name": "DS05899.7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10475307", "map_id": "none", "name": "Activated FGFR1:FLRT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9MSI4", "map_id": "M9MSI4", "name": "DS05899.7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475018", "map_id": "none", "name": "Activated FGFR1:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474866", "map_id": "none", "name": "Activated FGFR1:p-FRS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474868", "map_id": "none", "name": "Activated FGFR1:p-FRS2:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10493205", "map_id": "none", "name": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475022", "map_id": "none", "name": "Activated FGFR1:p-FRS:p-PTPN11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475001", "map_id": "none", "name": "Activated FGFR1 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474999", "map_id": "none", "name": "Activated FGFR1:FRS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474871", "map_id": "none", "name": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474995", "map_id": "none", "name": "Activated FGFR1 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475011", "map_id": "none", "name": "Activated FGFR1 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10474864", "map_id": "none", "name": "Activated FGFR1:p-FRS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475025", "map_id": "none", "name": "Activated FGFR1:p-FRS phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475020", "map_id": "none", "name": "Activated FGFR1:p-FRS:PTPN11", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475008", "map_id": "none", "name": "Activated FGFR1 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10465463", "map_id": "none", "name": "Activated FGFR1:p-FRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475165", "map_id": "none", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465467", "map_id": "none", "name": "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475029", "map_id": "none", "name": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465495", "map_id": "none", "name": "Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475027", "map_id": "none", "name": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465465", "map_id": "none", "name": "Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475168", "map_id": "none", "name": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465497", "map_id": "none", "name": "Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459327", "map_id": "none", "name": "Phosphorylation of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10459159", "map_id": "none", "name": "p-JAK2:SFKs:p-KIT complex:STATs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q24151", "map_id": "Q24151", "name": "Stat92E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Stat92E", "map_id": "Stat92E", "name": "Stat92E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24592", "map_id": "Q24592", "name": "phospho-hop", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-hop", "map_id": "phospho-hop", "name": "phospho-hop", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10459324", "map_id": "none", "name": "p-JAK2:SFKs:p-KIT complex:p-STATs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498528", "map_id": "none", "name": "KIT binds ripretinib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442600", "map_id": "none", "name": "Homologues of KIT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_9674322", "map_id": "none", "name": "ripretinib", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10498526", "map_id": "none", "name": "KIT:ripretinib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498434", "map_id": "none", "name": "KIT binds type II TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9669722", "map_id": "none", "name": "type II KIT binding TKIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10498432", "map_id": "none", "name": "KIT:type II TKIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459164", "map_id": "none", "name": "Activation of RAS by p-KIT bound SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442628", "map_id": "none", "name": "GRB2:SOS1:p-KIT complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459161", "map_id": "none", "name": "Recruitment of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10445861", "map_id": "Q24151", "name": "Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10459141", "map_id": "none", "name": "p-JAK2:SFKs:p-KIT complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459128", "map_id": "none", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459125", "map_id": "none", "name": "p-VAV1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459144", "map_id": "none", "name": "Phosphorylation of JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10459136", "map_id": "none", "name": "JAK2:SFKS:p-KIT complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459335", "map_id": "none", "name": "Disassociation and translocation of STATs to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10459329", "map_id": "none", "name": "p-JAK2:SFKs:p-KIT complex:p-STAT dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10458565", "map_id": "none", "name": "STAT5A homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10459157", "map_id": "none", "name": "PTP-RO interacts with p-c-Kit complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10459153", "map_id": "none", "name": "Homologues of PTPRU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VJ95", "map_id": "Q9VJ95", "name": "Ptp36E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267486", "map_id": "FBgn0267486", "name": "Ptp36E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAB3", "map_id": "A1ZAB3", "name": "Ptp52F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034085", "map_id": "FBgn0034085", "name": "Ptp52F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10459155", "map_id": "none", "name": "PTPRU:KIT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459331", "map_id": "none", "name": "Dimerization of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10459179", "map_id": "none", "name": "PKC alpha interacts with and phosphorylates KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10434436", "map_id": "P05130", "name": "Pkc53E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10459176", "map_id": "none", "name": "p-KIT (S741,746):PKC alpha", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10442632", "map_id": "none", "name": "Recruitment of CBL to KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442630", "map_id": "none", "name": "CBL:Grb2/p-APS:p-c-Kit complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458441", "map_id": "none", "name": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458438", "map_id": "none", "name": "GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458591", "map_id": "none", "name": "ERBB4s80 forms a complex with estrogen receptor ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458515", "map_id": "none", "name": "ERBB4s80", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10458587", "map_id": "none", "name": "ESR1 dimer:ESTG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_374146", "map_id": "CHEBI:50114", "name": "ESTG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q8WS79", "map_id": "Q8WS79", "name": "ERR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035849", "map_id": "FBgn0035849", "name": "ERR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458589", "map_id": "none", "name": "ERBB4s80:ESR1:estrogen", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458540", "map_id": "none", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458466", "map_id": "none", "name": "ERBB4s80", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10458536", "map_id": "Q9VLU5", "name": "Wwox", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031972", "map_id": "FBgn0031972", "name": "Wwox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458538", "map_id": "none", "name": "ERBB4s80:WWOX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VLU5", "map_id": "Q9VLU5", "name": "Wwox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458571", "map_id": "none", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458559", "map_id": "none", "name": "p-Y694-STAT5A homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10458561", "map_id": "none", "name": "ERBB4s80:p-Y694-STAT5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10458554", "map_id": "none", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458544", "map_id": "Q45VV3", "name": "yki", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458546", "map_id": "none", "name": "ERBB4s80:YAP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q45VV3", "map_id": "Q45VV3", "name": "yki", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "yki", "map_id": "yki", "name": "yki", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458505", "map_id": "none", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458456", "map_id": "none", "name": "ERBB4m80", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458569", "map_id": "none", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458567", "map_id": "none", "name": "ERBB4s80:p-Y694-STAT5A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458552", "map_id": "none", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458550", "map_id": "none", "name": "ERBB4s80:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458519", "map_id": "none", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458517", "map_id": "none", "name": "ERBB4s80:MyrG-p-Y419-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458583", "map_id": "none", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458581", "map_id": "none", "name": "ERBB4s80", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10462454", "map_id": "none", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10462447", "map_id": "none", "name": "ERBB4jmAcyt1s80:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VVI3", "map_id": "Q9VVI3", "name": "Nedd4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259174", "map_id": "FBgn0259174", "name": "Nedd4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10462451", "map_id": "none", "name": "Ub-ERBB4jmAcyt1s80:NEDD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10458531", "map_id": "none", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10456500", "map_id": "Q9Y0H4", "name": "Su(dx)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458522", "map_id": "none", "name": "ERBB4/ERBB4m80/ERBB4s80", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10458524", "map_id": "none", "name": "ERBB4/m80/s80:WWP1/ITCH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458529", "map_id": "none", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458526", "map_id": "none", "name": "Ub-ERBB4:WWP1/ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10462449", "map_id": "none", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10456484", "map_id": "Q9VVI3", "name": "Nedd4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458460", "map_id": "none", "name": "ERBB4jmAcyt1s80 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497518", "map_id": "none", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444503", "map_id": "P00528", "name": "phospho-Src64B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10476599", "map_id": "none", "name": "GRB2-1:SOS1 binds p-Y-SHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475810", "map_id": "Q9V3C8", "name": "phospho-Shc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475816", "map_id": "none", "name": "GRB2-1:SOS1:p-Y-SHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10437918", "map_id": "none", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437914", "map_id": "M9PCE9", "name": "Rgl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0026376", "map_id": "FBgn0026376", "name": "Rgl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437916", "map_id": "none", "name": "Ras-GTP:RalGDS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9PCE9", "map_id": "M9PCE9", "name": "Rgl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497488", "map_id": "none", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10497474", "map_id": "none", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10497463", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "P08645", "map_id": "P08645", "name": "Rap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004636", "map_id": "FBgn0004636", "name": "Rap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497467", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10497478", "map_id": "none", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497476", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10475873", "map_id": "none", "name": "p-2S MAP2K homo/heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10497461", "map_id": "none", "name": "RAP1:GTP:activated BRAF dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10433771", "map_id": "P40417", "name": "phospho-rl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10497465", "map_id": "none", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10475906", "map_id": "none", "name": "MAP2K homo/heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433742", "map_id": "P40417", "name": "rl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10497481", "map_id": "none", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475989", "map_id": "none", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10497486", "map_id": "none", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10497483", "map_id": "none", "name": "RAP1:GTP:B-Raf complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10438835", "map_id": "none", "name": "Axonal transport of NGF:Trk complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10438827", "map_id": "none", "name": "Activated TrkA receptor complex:Clathrin-coated vesicle:Endophilin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10438832", "map_id": "A1Z8T9", "name": "Dmel\\CG8407", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0033687", "map_id": "FBgn0033687", "name": "Dmel\\CG8407", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440762", "map_id": "none", "name": "PI3K produces PIP3 and other phosphatidyl inositides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10440759", "map_id": "none", "name": "Phospho-IRS1/2:PI3K(p85:p110)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XTN2", "map_id": "Q9XTN2", "name": "chico", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "chico", "map_id": "chico", "name": "chico", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441962", "map_id": "none", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10434902", "map_id": "P48148", "name": "Rho1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10441960", "map_id": "none", "name": "PIP3:RhoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10431807", "map_id": "none", "name": "GRB2-1:SOS1 binds p-IRS1,p-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431801", "map_id": "Q9XTN2", "name": "phospho-chico", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431805", "map_id": "none", "name": "GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10433706", "map_id": "none", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10433715", "map_id": "none", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433696", "map_id": "none", "name": "AKT2:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10433712", "map_id": "none", "name": "p-T309,S474-AKT2:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10433698", "map_id": "none", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10433694", "map_id": "none", "name": "AKT2:THEM4,TRIB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433688", "map_id": "Q9V3Z1", "name": "trbl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433683", "map_id": "none", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433680", "map_id": "none", "name": "PI3K-containing complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431824", "map_id": "none", "name": "p-Y-IRS1,p-Y-IRS2 bind PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431820", "map_id": "none", "name": "PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10431822", "map_id": "none", "name": "p-Y-IRS1,p-Y-IRS2:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431786", "map_id": "none", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10431784", "map_id": "none", "name": "insulin receptor", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "P09208", "map_id": "P09208", "name": "InR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "InR", "map_id": "InR", "name": "InR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10431589", "map_id": "none", "name": "Insulin receptor", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10431768", "map_id": "none", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "species_74722", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10431765", "map_id": "none", "name": "V-ATPase:ATP6AP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q24583", "map_id": "Q24583", "name": "Vha14-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262512", "map_id": "FBgn0262512", "name": "Vha14-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27331", "map_id": "Q27331", "name": "Vha68-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263598", "map_id": "FBgn0263598", "name": "Vha68-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3J1", "map_id": "Q9V3J1", "name": "VhaSFD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027779", "map_id": "FBgn0027779", "name": "VhaSFD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V7N5", "map_id": "Q9V7N5", "name": "Vha44", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262511", "map_id": "FBgn0262511", "name": "Vha44", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54611", "map_id": "P54611", "name": "Vha26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283535", "map_id": "FBgn0283535", "name": "Vha26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZH6", "map_id": "Q9XZH6", "name": "Vha13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283536", "map_id": "FBgn0283536", "name": "Vha13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P31409", "map_id": "P31409", "name": "Vha55", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005671", "map_id": "FBgn0005671", "name": "Vha55", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V7D2", "map_id": "Q9V7D2", "name": "Vha36-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022097", "map_id": "FBgn0022097", "name": "Vha36-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZ10", "map_id": "Q9XZ10", "name": "Vha100-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028671", "map_id": "FBgn0028671", "name": "Vha100-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKF6", "map_id": "Q9VKF6", "name": "Vha100-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032373", "map_id": "FBgn0032373", "name": "Vha100-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VE77", "map_id": "Q9VE77", "name": "Vha100-4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038613", "map_id": "FBgn0038613", "name": "Vha100-4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VE75", "map_id": "Q9VE75", "name": "Vha100-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028670", "map_id": "FBgn0028670", "name": "Vha100-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZBF7", "map_id": "A1ZBF7", "name": "Vha100-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028669", "map_id": "FBgn0028669", "name": "Vha100-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P23380", "map_id": "P23380", "name": "Vha16-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262736", "map_id": "FBgn0262736", "name": "Vha16-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4P5", "map_id": "Q9W4P5", "name": "VhaAC39-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0285910", "map_id": "FBgn0285910", "name": "VhaAC39-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCQ3", "map_id": "Q9VCQ3", "name": "VhaAC39-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039058", "map_id": "FBgn0039058", "name": "VhaAC39-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZE9", "map_id": "Q9VZE9", "name": "VhaM9.7-a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035521", "map_id": "FBgn0035521", "name": "VhaM9.7-a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZG7", "map_id": "Q9VZG7", "name": "VhaM9.7-c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028664", "map_id": "FBgn0028664", "name": "VhaM9.7-c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VP18", "map_id": "Q9VP18", "name": "VhaM9.7-b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028663", "map_id": "FBgn0028663", "name": "VhaM9.7-b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEQ6", "map_id": "Q9VEQ6", "name": "VhaM9.7-d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038458", "map_id": "FBgn0038458", "name": "VhaM9.7-d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFE3", "map_id": "Q9VFE3", "name": "VhaPPA1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028662", "map_id": "FBgn0028662", "name": "VhaPPA1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JR49", "map_id": "Q7JR49", "name": "VhaAC45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262515", "map_id": "FBgn0262515", "name": "VhaAC45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471490", "map_id": "none", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10431763", "map_id": "Q7JR49", "name": "VhaAC45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "species_10431758", "map_id": "none", "name": "V-ATPase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10433749", "map_id": "none", "name": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433747", "map_id": "none", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433740", "map_id": "P40417", "name": "rl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10476611", "map_id": "none", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433733", "map_id": "none", "name": "GRB2-1:p-4S-SOS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10433745", "map_id": "none", "name": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431832", "map_id": "none", "name": "GRB2-1:SOS1:p-Y427-SHC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433735", "map_id": "none", "name": "GRB2-1:p-4S-SOS1:p-Y427-SHC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476609", "map_id": "none", "name": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431830", "map_id": "Q9V3C8", "name": "phospho-Shc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433725", "map_id": "none", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431795", "map_id": "P26675", "name": "Sos", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10431834", "map_id": "none", "name": "GRB2-1:SOS1 binds p-Y427-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10446431", "map_id": "none", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446424", "map_id": "none", "name": "PDGF alpha receptor: PDGF dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VWP6", "map_id": "Q9VWP6", "name": "Pvf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030964", "map_id": "FBgn0030964", "name": "Pvf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446426", "map_id": "none", "name": "Phospho PDGF alpha receptor:PDGF dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446429", "map_id": "none", "name": "PDGFR:type I PDGFR-binding TKIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10489777", "map_id": "none", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10446192", "map_id": "none", "name": "proPDGF-AB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10489771", "map_id": "Q9VWP6", "name": "Pvf1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10439284", "map_id": "none", "name": "PDGF A/B heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10439338", "map_id": "Q9VWP6", "name": "Pvf1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10435798", "map_id": "P26016", "name": "Fur1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0004509", "map_id": "FBgn0004509", "name": "Fur1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446204", "map_id": "none", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10446186", "map_id": "none", "name": "PDGF precursor dimers (AA, BB, A/B, CC, DD)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10446202", "map_id": "none", "name": "PDGF precursor dimers (AA, BB, A/B, CC, DD)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10439340", "map_id": "none", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10439336", "map_id": "none", "name": "proPDGF-AA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10439276", "map_id": "none", "name": "active PDGF-AA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10439324", "map_id": "none", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439286", "map_id": "none", "name": "Active PDGF dimers (AA, AB, BB)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10439308", "map_id": "none", "name": "PDGFRA, PDGFRB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439318", "map_id": "none", "name": "PDGF:PDGF receptor dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439320", "map_id": "none", "name": "PDGFR:type II PDGFR-binding TKIs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439322", "map_id": "none", "name": "PDGFRA:olaratumab", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498453", "map_id": "none", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9674075", "map_id": "none", "name": "type I PDGFR-binding tyrosine kinase inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10446441", "map_id": "none", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446436", "map_id": "none", "name": "PDGF alpha/beta:PDGF AB and BB dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446438", "map_id": "none", "name": "Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498455", "map_id": "none", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9674079", "map_id": "none", "name": "type II PDGFR-binding tyrosine kinase inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10439359", "map_id": "none", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439328", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439294", "map_id": "none", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439288", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439292", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:PLC-gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439356", "map_id": "none", "name": "GAP binds to PDGF-beta receptors only", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439344", "map_id": "none", "name": "Phospho PDGF beta receptor: PDGF chain B homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439354", "map_id": "none", "name": "Phospho-beta receptor homodimer:GAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10445851", "map_id": "none", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439361", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:MyrG-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10445848", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446232", "map_id": "none", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446230", "map_id": "none", "name": "PDGF:Phospho-PDGFR receptor dimer:Nck", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446164", "map_id": "none", "name": "p130Cas and C3G bind PDGFR bound Crk", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446160", "map_id": "O77086", "name": "C3G", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0259228", "map_id": "FBgn0259228", "name": "C3G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446150", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:Crk", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9XYM0", "map_id": "Q9XYM0", "name": "Crk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024811", "map_id": "FBgn0024811", "name": "Crk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446155", "map_id": "A4IJ58", "name": "p130CAS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035101", "map_id": "FBgn0035101", "name": "p130CAS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446162", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A4IJ58", "map_id": "A4IJ58", "name": "p130CAS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O77086", "map_id": "O77086", "name": "C3G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459917", "map_id": "none", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10459912", "map_id": "none", "name": "PDGF:p-PDGFR dimer:p-PLCgamma", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10445867", "map_id": "none", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445855", "map_id": "Q24151", "name": "Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10445865", "map_id": "none", "name": "PDGF:phospho-PDGF receptor dimer:STAT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459914", "map_id": "none", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10439370", "map_id": "none", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439365", "map_id": "none", "name": "PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439367", "map_id": "none", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10446214", "map_id": "none", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446146", "map_id": "Q9XYM0", "name": "Crk", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10439363", "map_id": "none", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10438881", "map_id": "P00528", "name": "Src64B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10439330", "map_id": "none", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10446228", "map_id": "none", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10446216", "map_id": "none", "name": "Novel PDGF precursor dimers (CC, DD)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10446226", "map_id": "none", "name": "Novel PDGF precursor dimers (CC, DD)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10439347", "map_id": "none", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439342", "map_id": "none", "name": "PDGF beta receptor:PDGF chain B homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10489775", "map_id": "none", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10446190", "map_id": "none", "name": "proPDGF-BB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10439282", "map_id": "none", "name": "active PDGF-BB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10479727", "map_id": "none", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479721", "map_id": "none", "name": "p-ERBB2 heterodimers:MEMO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VG04", "map_id": "Q9VG04", "name": "dMEMO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038110", "map_id": "FBgn0038110", "name": "dMEMO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475516", "map_id": "none", "name": "RHOA:GTP:DIAPH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10479725", "map_id": "none", "name": "p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10479723", "map_id": "none", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458352", "map_id": "none", "name": "p-ERBB2 heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10479719", "map_id": "Q9VG04", "name": "dMEMO", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498279", "map_id": "none", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9652360", "map_id": "none", "name": "lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10462124", "map_id": "none", "name": "ERBB2:ERBIN:HSP90:CDC37", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10462235", "map_id": "none", "name": "ERBB2:TKIs:ERBIN:HSP90:CDC37", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10462237", "map_id": "none", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10462226", "map_id": "none", "name": "EGF:EGFR:ERBB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10458345", "map_id": "none", "name": "EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10462231", "map_id": "none", "name": "ERBB2:trastuzumab:ERBIN:HSP90:CDC37", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458911", "map_id": "none", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458908", "map_id": "none", "name": "EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458913", "map_id": "none", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458904", "map_id": "none", "name": "EGF:p-EGFR:p-ERBB2:GRB2:GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458920", "map_id": "none", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458917", "map_id": "none", "name": "NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10462245", "map_id": "none", "name": "SRC family kinases phosphorylate ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10462221", "map_id": "none", "name": "EGF:EGFR:p-Y877-ERBB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458359", "map_id": "none", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458354", "map_id": "none", "name": "SHC1:Phosphorylated ERBB2 heterodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10458356", "map_id": "none", "name": "p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10491995", "map_id": "none", "name": "Activated PKC phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491981", "map_id": "Q9V3C8", "name": "phospho-Shc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10491992", "map_id": "none", "name": "Activated PRKCA,(PRKCD,PRKCE)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_33625", "map_id": "CHEBI:18303", "name": "PS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10489700", "map_id": "none", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489685", "map_id": "none", "name": "Phosphorylated ERBB2:EGFR heterodimers:PTPN18", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10489697", "map_id": "none", "name": "Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10462217", "map_id": "none", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10462213", "map_id": "Q8INJ8", "name": "Csk", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10462215", "map_id": "none", "name": "p-ERBB2 heterodimers:MATK", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10462134", "map_id": "none", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10462131", "map_id": "none", "name": "Ub-ERBB2:ERBIN:HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10456634", "map_id": "Q9VAQ0", "name": "Cul5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0039632", "map_id": "FBgn0039632", "name": "Cul5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458958", "map_id": "none", "name": "RNF41 ubiquitinates activated ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458953", "map_id": "none", "name": "NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VUV7", "map_id": "Q9VUV7", "name": "elgi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283649", "map_id": "FBgn0283649", "name": "elgi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458955", "map_id": "none", "name": "NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10456701", "map_id": "Q9VUV7", "name": "elgi", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10458939", "map_id": "none", "name": "RNF41 ubiquitinates ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458934", "map_id": "none", "name": "ERBB3:RNF41", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10458936", "map_id": "none", "name": "Ub-ERBB3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458967", "map_id": "none", "name": "ERBB3 binds RNF41 ubiquitin ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458281", "map_id": "P04412", "name": "Egfr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10458949", "map_id": "none", "name": "Phosphorylation of USP8 by P-AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458944", "map_id": "Q9VDD8", "name": "Usp8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0038862", "map_id": "FBgn0038862", "name": "phospho-Usp8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458947", "map_id": "Q9VDD8", "name": "phospho-Usp8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10458965", "map_id": "none", "name": "Ubiquitinated RNF41 binds P-USP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458929", "map_id": "none", "name": "Ub-RNF41", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10458960", "map_id": "none", "name": "Ub-RNF41:p-USP8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VDD8", "map_id": "Q9VDD8", "name": "phospho-Usp8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458932", "map_id": "none", "name": "Self-ubiquitination of RNF41", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10458963", "map_id": "none", "name": "Deubiquitination of RNF41 by P-USP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10462129", "map_id": "none", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10462126", "map_id": "none", "name": "Ub-ERBB2:ERBIN:Ub-HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10456460", "map_id": "Q9XYW6", "name": "STUB1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0027052", "map_id": "FBgn0027052", "name": "STUB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10462224", "map_id": "none", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458350", "map_id": "none", "name": "EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498464", "map_id": "none", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_459", "compartment_display": "cytoplasm" }, { "id": "species_10498460", "map_id": "M9NE98", "name": "Dmel\\CG5114", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036460", "map_id": "FBgn0036460", "name": "Dmel\\CG5114", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438846", "map_id": "P04412", "name": "Egfr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10498462", "map_id": "none", "name": "EGFR:AAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9NE98", "map_id": "M9NE98", "name": "Dmel\\CG5114", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438959", "map_id": "none", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438855", "map_id": "none", "name": "EGF-like ligands:EGFR dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10438908", "map_id": "none", "name": "EGF-like ligands:p-6Y EGFR dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439003", "map_id": "none", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10438851", "map_id": "A1Z9D7", "name": "arr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10438853", "map_id": "none", "name": "EGFR:EGF-like ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439001", "map_id": "A1ZAB1", "name": "lbk", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0034083", "map_id": "FBgn0034083", "name": "lbk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438857", "map_id": "none", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10443325", "map_id": "none", "name": "Active PLC-gamma1 dissociates from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10443320", "map_id": "none", "name": "EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10443323", "map_id": "none", "name": "EGFR activates PLC-gamma1 by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10443316", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:PLCG1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10443318", "map_id": "none", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10441886", "map_id": "Q9VXH3", "name": "sl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10438943", "map_id": "none", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438937", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10438910", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10438927", "map_id": "none", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438912", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10438925", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10438841", "map_id": "none", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433424", "map_id": "Q9VZZ9", "name": "dos", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10438969", "map_id": "none", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438967", "map_id": "none", "name": "EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10438996", "map_id": "none", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438935", "map_id": "none", "name": "GRB2:GAB1,GRB2:GAB1:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10439027", "map_id": "none", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438933", "map_id": "none", "name": "GRB2:GAB1:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10438915", "map_id": "none", "name": "Sustained activation of SRC kinase by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438877", "map_id": "none", "name": "p-Y-PXN:CSK:MyrG,p-Y530-SRC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10438883", "map_id": "none", "name": "PXN:MyrG-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10438862", "map_id": "Q8INJ8", "name": "Csk", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10438994", "map_id": "none", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438991", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439199", "map_id": "none", "name": "CBL binds and ubiquitinates phosphorylated Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439111", "map_id": "O44783", "name": "sty", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439039", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439174", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439103", "map_id": "none", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439090", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W111", "map_id": "Q9W111", "name": "phospho-Eps-15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035060", "map_id": "FBgn0035060", "name": "phospho-Eps-15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTL2", "map_id": "Q9XTL2", "name": "Stam", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027363", "map_id": "FBgn0027363", "name": "Stam", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q960X8", "map_id": "Q960X8", "name": "Hrs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031450", "map_id": "FBgn0031450", "name": "Hrs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS85", "map_id": "Q9VS85", "name": "lqf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028582", "map_id": "FBgn0028582", "name": "lqf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10439100", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439197", "map_id": "none", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439192", "map_id": "none", "name": "EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439185", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:GRB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439194", "map_id": "none", "name": "Ub-Beta-Pix:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10439164", "map_id": "none", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439132", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439156", "map_id": "none", "name": "EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439162", "map_id": "Q9VJ95", "name": "Ptp36E", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10439130", "map_id": "none", "name": "Ubiquitination of stimulated EGFR (CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439127", "map_id": "none", "name": "EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439190", "map_id": "none", "name": "Localization of CBL:GRB2 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439179", "map_id": "none", "name": "CBL:GRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10439125", "map_id": "none", "name": "Sprouty sequesters CBL away from active EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439119", "map_id": "O44783", "name": "sty", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10439123", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439188", "map_id": "none", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10439152", "map_id": "none", "name": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439146", "map_id": "none", "name": "Beta-Pix:CDC42:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10439148", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439150", "map_id": "none", "name": "EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439183", "map_id": "none", "name": "Binding of CBL to EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439034", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10490064", "map_id": "none", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490059", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10490061", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439181", "map_id": "none", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10439117", "map_id": "none", "name": "Sprouty lures CBL away from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439109", "map_id": "O44783", "name": "phospho-sty", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439115", "map_id": "none", "name": "CBL:SPRY1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10490066", "map_id": "none", "name": "EGFR binds EPS15, EPN1, EPS15L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439047", "map_id": "Q9VS85", "name": "lqf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10439066", "map_id": "none", "name": "EPS15:HGS:STAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10439068", "map_id": "Q9W111", "name": "Eps-15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10439177", "map_id": "none", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439170", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10490074", "map_id": "none", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490071", "map_id": "Q9W0R3", "name": "Ptpmeg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0261985", "map_id": "FBgn0261985", "name": "Ptpmeg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439203", "map_id": "none", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439201", "map_id": "none", "name": "CBL:Beta-Pix:CDC42:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10439042", "map_id": "none", "name": "Phosphorylation of CBL (EGFR:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10438973", "map_id": "none", "name": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438953", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10438971", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10438956", "map_id": "none", "name": "SHC1 phosphorylation by phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438929", "map_id": "none", "name": "EGF-like ligands:p-6Y EGFR:SHC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10438931", "map_id": "none", "name": "SHC1 binds to the phosphorylated EGF receptor:ligand complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431840", "map_id": "Q9V3C8", "name": "Shc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10439009", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10438978", "map_id": "none", "name": "Phosphorylation of EGFR by SRC kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10439006", "map_id": "none", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438982", "map_id": "none", "name": "EGF-like ligands:p-6Y-EGFR:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10438985", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10486291", "map_id": "none", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486280", "map_id": "Q7KMQ6", "name": "Pten", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10486289", "map_id": "Q7KMQ6", "name": "Pten", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10467616", "map_id": "Q9VYQ8", "name": "Usp7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0030366", "map_id": "FBgn0030366", "name": "Usp7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486293", "map_id": "none", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441147", "map_id": "Q7KMQ6", "name": "Pten", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10486282", "map_id": "none", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486276", "map_id": "Q7KMQ6", "name": "Pten", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10486287", "map_id": "none", "name": "PTEN undergoes monoubiquitination", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486284", "map_id": "none", "name": "XIAP,NEDD4", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433277", "map_id": "none", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433273", "map_id": "none", "name": "capped intronless pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10429982", "map_id": "none", "name": "CPSF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V726", "map_id": "Q9V726", "name": "Cpsf160", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024698", "map_id": "FBgn0024698", "name": "Cpsf160", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VN31", "map_id": "Q9VN31", "name": "Fip1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037255", "map_id": "FBgn0037255", "name": "Fip1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNG2", "map_id": "Q9VNG2", "name": "Wdr33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0046222", "map_id": "FBgn0046222", "name": "Wdr33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VE51", "map_id": "Q9VE51", "name": "Cpsf73", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261065", "map_id": "FBgn0261065", "name": "Cpsf73", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MSU4", "map_id": "Q8MSU4", "name": "Sym", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037371", "map_id": "FBgn0037371", "name": "Sym", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3D6", "map_id": "Q9V3D6", "name": "Cpsf100", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027873", "map_id": "FBgn0027873", "name": "Cpsf100", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPT8", "map_id": "Q9VPT8", "name": "Clp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015621", "map_id": "FBgn0015621", "name": "Clp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10433275", "map_id": "none", "name": "CPSF:capped intronless pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433287", "map_id": "none", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433283", "map_id": "none", "name": "intronless pre-mRNA cleavage complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VE52", "map_id": "Q9VE52", "name": "CstF64", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027841", "map_id": "FBgn0027841", "name": "CstF64", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25991", "map_id": "P25991", "name": "su(f)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003559", "map_id": "FBgn0003559", "name": "su(f)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9V0", "map_id": "Q9V9V0", "name": "CstF50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039867", "map_id": "FBgn0039867", "name": "CstF50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E8G6", "map_id": "Q0E8G6", "name": "Cpsf5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035987", "map_id": "FBgn0035987", "name": "Cpsf5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSH4", "map_id": "Q9VSH4", "name": "Cpsf6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035872", "map_id": "FBgn0035872", "name": "Cpsf6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KNF2", "map_id": "Q7KNF2", "name": "Pabp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005648", "map_id": "FBgn0005648", "name": "Pabp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K284", "map_id": "Q7K284", "name": "cbc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033842", "map_id": "FBgn0033842", "name": "cbc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z9W4", "map_id": "A1Z9W4", "name": "Pcf11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264962", "map_id": "FBgn0264962", "name": "Pcf11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10430001", "map_id": "none", "name": "CstF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10430036", "map_id": "none", "name": "CF II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433285", "map_id": "none", "name": "upstream mRNA fragment:CPSF:PAP:PABPN1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10430024", "map_id": "none", "name": "CF I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_112165", "map_id": "none", "name": "downstream intronless mRNA fragment", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433281", "map_id": "none", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433279", "map_id": "none", "name": "CstF:CPSF:capped intronless pre-mRNA:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10461644", "map_id": "none", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2024002", "map_id": "CHEBI:16783", "name": "I(1,3,4,5)P4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113551", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2024016", "map_id": "CHEBI:16595", "name": "I(1,4,5)P3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10461541", "map_id": "Q9VV72", "name": "Mipp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "FBgn0026061", "map_id": "FBgn0026061", "name": "Mipp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461544", "map_id": "none", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2024008", "map_id": "CHEBI:16322", "name": "I(1,3,4,5,6)P5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2024012", "map_id": "CHEBI:16067", "name": "I(1,4,5,6)P4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10461732", "map_id": "none", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2024018", "map_id": "CHEBI:17401", "name": "IP6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2564836", "map_id": "CHEBI:16507", "name": "I(1,2,4,5,6)P5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10473766", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10473760", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10473764", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475670", "map_id": "none", "name": "p-T774-PKN1 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475665", "map_id": "none", "name": "p-T774-PKN1:CDC25C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q03019", "map_id": "Q03019", "name": "twe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002673", "map_id": "FBgn0002673", "name": "twe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20483", "map_id": "P20483", "name": "stg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003525", "map_id": "FBgn0003525", "name": "stg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10431988", "map_id": "none", "name": "Homologues of p-S216-CDC25C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10473769", "map_id": "A1Z7T0", "name": "phospho-Pkn", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10432022", "map_id": "none", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432018", "map_id": "none", "name": "14-3-3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P92177", "map_id": "P92177", "name": "14-3-3epsilon", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "14-3-3epsilon", "map_id": "14-3-3epsilon", "name": "14-3-3epsilon", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432020", "map_id": "none", "name": "p-S216-CDC25C:14-3-3 protein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475685", "map_id": "none", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475630", "map_id": "none", "name": "Myosin phosphatase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "M9NEB2", "map_id": "M9NEB2", "name": "phospho-Mbs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005536", "map_id": "FBgn0005536", "name": "phospho-Mbs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48462", "map_id": "P48462", "name": "flw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "flw", "map_id": "flw", "name": "flw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475678", "map_id": "Q9VKQ5", "name": "phospho-Dmel\\CG17124", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0032297", "map_id": "FBgn0032297", "name": "phospho-Dmel\\CG17124", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475683", "map_id": "none", "name": "MLCP:p-T38-PPP1R14A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VKQ5", "map_id": "Q9VKQ5", "name": "phospho-Dmel\\CG17124", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475667", "map_id": "none", "name": "p-T774-PKN1 binds CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435503", "map_id": "none", "name": "Homologues of CDC25C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10473762", "map_id": "none", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10473750", "map_id": "A1Z7T0", "name": "Pkn", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10473758", "map_id": "none", "name": "RHOA,RHOB,RHOC,RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10473778", "map_id": "none", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474173", "map_id": "none", "name": "Phosphorylated PKN1 binds androgen receptor (AR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10473330", "map_id": "none", "name": "AR:Androgens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_193057", "map_id": "CHEBI:17347", "name": "TEST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_193079", "map_id": "CHEBI:16422", "name": "ANDST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_469662", "map_id": "CHEBI:16330", "name": "DHTEST", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:29117", "map_id": "CHEBI:29117", "name": "CHEBI:29117", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474171", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10474183", "map_id": "none", "name": "PKN1 stimulates association of AR with NCOA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474177", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10440442", "map_id": "M9ND53", "name": "tai", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0041092", "map_id": "FBgn0041092", "name": "tai", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474181", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen:NCOA2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9ND53", "map_id": "M9ND53", "name": "tai", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474179", "map_id": "none", "name": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475681", "map_id": "none", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475675", "map_id": "Q9VKQ5", "name": "Dmel\\CG17124", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10475533", "map_id": "none", "name": "MKL1 translocates from cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475531", "map_id": "B7Z043", "name": "Mrtf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0052296", "map_id": "FBgn0052296", "name": "Mrtf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469150", "map_id": "B7Z043", "name": "Mrtf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469116", "map_id": "none", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469108", "map_id": "none", "name": "ppDVL:DAAM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10469112", "map_id": "none", "name": "RHOA:GTP:Mg2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10469114", "map_id": "none", "name": "ppDVL:DAAM1:RHOA:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475529", "map_id": "none", "name": "MKL1 binds SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475525", "map_id": "Q24535", "name": "bs", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0004101", "map_id": "FBgn0004101", "name": "bs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475527", "map_id": "none", "name": "SRF:MKL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "B7Z043", "map_id": "B7Z043", "name": "Mrtf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24535", "map_id": "Q24535", "name": "bs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475542", "map_id": "none", "name": "SCAI binds SRF:MKL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475538", "map_id": "M9PER3", "name": "Dmel\\CG13293", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0035677", "map_id": "FBgn0035677", "name": "Dmel\\CG13293", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475540", "map_id": "none", "name": "SRF:MKL1:SCAI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9PER3", "map_id": "M9PER3", "name": "Dmel\\CG13293", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475558", "map_id": "none", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475552", "map_id": "none", "name": "RHOD:GTP:DIAPH2-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10440003", "map_id": "P00528", "name": "Src64B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475556", "map_id": "none", "name": "RHOD:GTP:DIAPH2:SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10469110", "map_id": "none", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469106", "map_id": "M9MSM5", "name": "DAAM", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441719", "map_id": "P51140", "name": "phospho-dsh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10475554", "map_id": "none", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475546", "map_id": "none", "name": "DIAPH2-3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475457", "map_id": "none", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475453", "map_id": "none", "name": "FMNL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VUC6", "map_id": "Q9VUC6", "name": "Frl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267795", "map_id": "FBgn0267795", "name": "Frl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475455", "map_id": "none", "name": "CDC42:GTP:FMNL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475520", "map_id": "none", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475514", "map_id": "none", "name": "DIAPH1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464334", "map_id": "none", "name": "PAK1 phosphorylates LIMK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10495682", "map_id": "none", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446521", "map_id": "none", "name": "PAK3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10446509", "map_id": "none", "name": "CDC42:GTP, RAC1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474308", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446519", "map_id": "B7Z0W0", "name": "Pak", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10495684", "map_id": "none", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474306", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446515", "map_id": "B7Z0W0", "name": "Pak", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10475643", "map_id": "none", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464328", "map_id": "Q24564", "name": "Mer", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0086384", "map_id": "FBgn0086384", "name": "Mer", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475641", "map_id": "none", "name": "PAK1:NF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q24564", "map_id": "Q24564", "name": "Mer", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464330", "map_id": "none", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446525", "map_id": "none", "name": "PAK1,2,3:CDC42:GTP, RAC1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10474313", "map_id": "none", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474310", "map_id": "none", "name": "CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475657", "map_id": "none", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475647", "map_id": "none", "name": "p-S144,T423-PAK1:FLNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10475654", "map_id": "none", "name": "p-S2152-FLNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475622", "map_id": "none", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475599", "map_id": "none", "name": "Smooth muscle/non-muscle myosin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VG88", "map_id": "Q9VG88", "name": "phospho-CT39356", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053098", "map_id": "FBgn0053098", "name": "phospho-CT39356", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P40423", "map_id": "P40423", "name": "phospho-sqh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-sqh", "map_id": "phospho-sqh", "name": "phospho-sqh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18432", "map_id": "P18432", "name": "phospho-Mlc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002773", "map_id": "FBgn0002773", "name": "phospho-Mlc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4B1", "map_id": "Q9W4B1", "name": "Dmel\\CG34435", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085464", "map_id": "FBgn0085464", "name": "Dmel\\CG34435", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQA5", "map_id": "Q9VQA5", "name": "Dmel\\CG17237", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031410", "map_id": "FBgn0031410", "name": "Dmel\\CG17237", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54357", "map_id": "P54357", "name": "Mlc-c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Mlc-c", "map_id": "Mlc-c", "name": "Mlc-c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P06742", "map_id": "P06742", "name": "Mlc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002772", "map_id": "FBgn0002772", "name": "Mlc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q99323", "map_id": "Q99323", "name": "zip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "zip", "map_id": "zip", "name": "zip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475619", "map_id": "none", "name": "p-T19-MRLC-Smooth muscle/non-muscle myosin II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10447065", "map_id": "B7Z0W0", "name": "phospho-Pak", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10475637", "map_id": "none", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475635", "map_id": "none", "name": "p-T696-PPP1R12A-Myosin phosphatase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475649", "map_id": "none", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475645", "map_id": "none", "name": "FLNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10481326", "map_id": "none", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_1524165", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629751", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10481323", "map_id": "none", "name": "PIK3C3:PIK3R4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "Q9VHH2", "map_id": "Q9VHH2", "name": "Vps15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260935", "map_id": "FBgn0260935", "name": "Vps15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1M7", "map_id": "Q9W1M7", "name": "Pi3K59F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015277", "map_id": "FBgn0015277", "name": "Pi3K59F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464910", "map_id": "none", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10464452", "map_id": "none", "name": "p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10464460", "map_id": "none", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464456", "map_id": "none", "name": "WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10464458", "map_id": "none", "name": "Mother filament:branching complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464473", "map_id": "none", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464428", "map_id": "none", "name": "p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465367", "map_id": "none", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464454", "map_id": "none", "name": "WAVE2, WASP, N-WASP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10464494", "map_id": "none", "name": "Mother filament:ARP2/3:actin:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464496", "map_id": "none", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10429887", "map_id": "Q9VHV6", "name": "Dmel\\CG9667", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10429943", "map_id": "none", "name": "Spliceosomal B Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7JVL3", "map_id": "Q7JVL3", "name": "Prp38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10429534", "map_id": "Q9VQK5", "name": "Prp40", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10430071", "map_id": "none", "name": "Formation of an intermediate Spliceosomal C (Bact) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10430048", "map_id": "Q9VIZ3", "name": "l(2)37Cb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10430053", "map_id": "Q9VES0", "name": "Dmel\\CG10324", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10430038", "map_id": "none", "name": "Cleavage and Polyadenylation Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10430058", "map_id": "Q9VQF5", "name": "Cwc25", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10430043", "map_id": "Q9VHS8", "name": "EIF4A3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10429409", "map_id": "none", "name": "U1 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10429860", "map_id": "Q9W1I6", "name": "ytr", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10429768", "map_id": "none", "name": "U4 snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10429865", "map_id": "Q9VWP1", "name": "Usp39", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10429807", "map_id": "none", "name": "LSM2-8 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10429855", "map_id": "Q95TU2", "name": "Dmel\\CG6686", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10435479", "map_id": "none", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10430113", "map_id": "none", "name": "Magoh-Y14 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P49028", "map_id": "P49028", "name": "mago", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002736", "map_id": "FBgn0002736", "name": "mago", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V535", "map_id": "Q9V535", "name": "tsu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033378", "map_id": "FBgn0033378", "name": "tsu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10430097", "map_id": "none", "name": "Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W1H3", "map_id": "Q9W1H3", "name": "Upf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034923", "map_id": "FBgn0034923", "name": "Upf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V5Q4", "map_id": "Q9V5Q4", "name": "Syf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033556", "map_id": "FBgn0033556", "name": "Syf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q960Q8", "map_id": "Q960Q8", "name": "Dmel\\CG3511", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035027", "map_id": "FBgn0035027", "name": "Dmel\\CG3511", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10430117", "map_id": "none", "name": "pre-EJC:Spliceosomal C:pre-mRNP:CBC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10430099", "map_id": "none", "name": "Lariat Formation and 5'-Splice Site Cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10430081", "map_id": "Q9W1H3", "name": "Upf3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10430083", "map_id": "P19018", "name": "tra2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10430088", "map_id": "Q9V5Q4", "name": "Syf2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10430093", "map_id": "Q960Q8", "name": "Dmel\\CG3511", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10479004", "map_id": "none", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5694509", "map_id": "CHEBI:75571", "name": "3AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_422506", "map_id": "CHEBI:15843", "name": "AA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_76116", "map_id": "CHEBI:17754", "name": "Glycerol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479001", "map_id": "A1ZBH3", "name": "Dmel\\CG15111", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0034419", "map_id": "FBgn0034419", "name": "Dmel\\CG15111", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448215", "map_id": "none", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426026", "map_id": "CHEBI:35366", "name": "Fatty Acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_426030", "map_id": "CHEBI:52392", "name": "2AG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10448212", "map_id": "B7Z150", "name": "inaE", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0261244", "map_id": "FBgn0261244", "name": "inaE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478699", "map_id": "none", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10478691", "map_id": "none", "name": "USO1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W3N6", "map_id": "Q9W3N6", "name": "p115", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040087", "map_id": "FBgn0040087", "name": "p115", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10478647", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "Q9VUZ1", "map_id": "Q9VUZ1", "name": "Trs20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266724", "map_id": "FBgn0266724", "name": "Trs20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VF82", "map_id": "Q9VF82", "name": "Trs33", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266722", "map_id": "FBgn0266722", "name": "Trs33", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLI9", "map_id": "Q9VLI9", "name": "Trs23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260861", "map_id": "FBgn0260861", "name": "Trs23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFB7", "map_id": "Q9VFB7", "name": "SIDL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038303", "map_id": "FBgn0038303", "name": "SIDL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSY8", "map_id": "Q9VSY8", "name": "Bet3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260859", "map_id": "FBgn0260859", "name": "Bet3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIL0", "map_id": "Q9VIL0", "name": "brun", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261787", "map_id": "FBgn0261787", "name": "brun", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA95", "map_id": "Q9VA95", "name": "Bet5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260860", "map_id": "FBgn0260860", "name": "Bet5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8I0", "map_id": "A1Z8I0", "name": "Dmel\\CG9067", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033605", "map_id": "FBgn0033605", "name": "Dmel\\CG9067", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K2Q8", "map_id": "Q7K2Q8", "name": "Trs31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266723", "map_id": "FBgn0266723", "name": "Trs31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49858", "map_id": "P49858", "name": "cni", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000339", "map_id": "FBgn0000339", "name": "cni", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JYA0", "map_id": "Q7JYA0", "name": "Dmel\\CG6337", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033873", "map_id": "FBgn0033873", "name": "Dmel\\CG6337", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3A8", "map_id": "Q9V3A8", "name": "ergic53", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035909", "map_id": "FBgn0035909", "name": "ergic53", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z813", "map_id": "A1Z813", "name": "Sec24AB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033460", "map_id": "FBgn0033460", "name": "Sec24AB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PC99", "map_id": "M9PC99", "name": "Sec24CD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262126", "map_id": "FBgn0262126", "name": "Sec24CD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLS7", "map_id": "Q9VLS7", "name": "PAPLA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031990", "map_id": "FBgn0031990", "name": "PAPLA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PGI6", "map_id": "M9PGI6", "name": "Sec22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260855", "map_id": "FBgn0260855", "name": "Sec22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10478684", "map_id": "none", "name": "GOLGA2:GORASP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10478697", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10478650", "map_id": "none", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10478643", "map_id": "none", "name": "COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle", "complex": "true" }, { "id": "reaction_10487625", "map_id": "none", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10487621", "map_id": "Q9W5H8", "name": "Dmel\\CG17883", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "FBgn0040005", "map_id": "FBgn0040005", "name": "Dmel\\CG17883", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486338", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "M9PE35", "map_id": "M9PE35", "name": "RabX6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035155", "map_id": "FBgn0035155", "name": "RabX6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487623", "map_id": "none", "name": "RAB1:GTP:TBC1D20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q9W5H8", "map_id": "Q9W5H8", "name": "Dmel\\CG17883", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478773", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10478768", "map_id": "none", "name": "cis-SNARE:NSF hexamer:3xSNAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q24179", "map_id": "Q24179", "name": "Slh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264978", "map_id": "FBgn0264978", "name": "Slh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRL2", "map_id": "Q9VRL2", "name": "Membrin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260856", "map_id": "FBgn0260856", "name": "Membrin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVX6", "map_id": "Q9VVX6", "name": "Bet1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260857", "map_id": "FBgn0260857", "name": "Bet1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24509", "map_id": "Q24509", "name": "Syx5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011708", "map_id": "FBgn0011708", "name": "Syx5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46461", "map_id": "P46461", "name": "comt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000346", "map_id": "FBgn0000346", "name": "comt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54351", "map_id": "P54351", "name": "Nsf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266464", "map_id": "FBgn0266464", "name": "Nsf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23983", "map_id": "Q23983", "name": "alphaSnap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250791", "map_id": "FBgn0250791", "name": "alphaSnap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10478736", "map_id": "none", "name": "SNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10478756", "map_id": "Q24509", "name": "Syx5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10478741", "map_id": "Q9VVX6", "name": "Bet1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10478727", "map_id": "none", "name": "NSF hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10478746", "map_id": "Q9VRL2", "name": "Membrin", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10478764", "map_id": "none", "name": "ER-to-ERGIC v-SNARES", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10478751", "map_id": "Q24179", "name": "Slh", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10478996", "map_id": "none", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10478758", "map_id": "none", "name": "BET1:GOSR2:STX5:SCFD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10478892", "map_id": "none", "name": "COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10478994", "map_id": "none", "name": "COPII cargo:receptors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10478766", "map_id": "none", "name": "cis-SNARE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10487628", "map_id": "none", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10478404", "map_id": "none", "name": "RAB1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10478770", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "reaction_10442369", "map_id": "none", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442357", "map_id": "none", "name": "SAR1B:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VD29", "map_id": "Q9VD29", "name": "Sar1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038947", "map_id": "FBgn0038947", "name": "Sar1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10442361", "map_id": "none", "name": "SAR1B:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10442366", "map_id": "Q9VMH4", "name": "Dmel\\CG9175", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0031779", "map_id": "FBgn0031779", "name": "Dmel\\CG9175", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10447503", "map_id": "none", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447494", "map_id": "Q59DP9", "name": "PMCA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0259214", "map_id": "FBgn0259214", "name": "PMCA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455452", "map_id": "none", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947588", "map_id": "none", "name": "APLs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane", "complex": "true" }, { "id": "species_1602375", "map_id": "CHEBI:16038", "name": "PE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_947594", "map_id": "none", "name": "APLs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_947586", "compartment_display": "external side of plasma membrane", "complex": "true" }, { "id": "species_10455391", "map_id": "none", "name": "P-type ATPases type IV", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B7YZF8", "map_id": "B7YZF8", "name": "ATP8A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259221", "map_id": "FBgn0259221", "name": "ATP8A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTG6", "map_id": "Q7KTG6", "name": "CG18419", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032120", "map_id": "FBgn0032120", "name": "CG18419", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGD4", "map_id": "Q9VGD4", "name": "ATP8B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037989", "map_id": "FBgn0037989", "name": "ATP8B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXG6", "map_id": "Q9VXG6", "name": "Dmel\\CG4301", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030747", "map_id": "FBgn0030747", "name": "Dmel\\CG4301", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXG7", "map_id": "Q9VXG7", "name": "DmCG9981", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030746", "map_id": "FBgn0030746", "name": "DmCG9981", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10447514", "map_id": "none", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane" }, { "id": "species_427899", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114580", "compartment_display": "platelet dense tubular network lumen", "complex": "false" }, { "id": "species_139827", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114580", "compartment_display": "platelet dense tubular network lumen", "complex": "false" }, { "id": "species_10447507", "map_id": "P22700", "name": "SERCA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "false" }, { "id": "reaction_10477993", "map_id": "none", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29418", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1981162", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10477990", "map_id": "Q9VKJ6", "name": "Dmel\\CG6230", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0027582", "map_id": "FBgn0027582", "name": "Dmel\\CG6230", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455270", "map_id": "none", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_167012", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10455267", "map_id": "none", "name": "ATP2C1/2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "M9PG15", "map_id": "M9PG15", "name": "SPoCk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052451", "map_id": "FBgn0052451", "name": "SPoCk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455334", "map_id": "none", "name": "ATP4A/12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10455331", "map_id": "none", "name": "ATP4A/12A:ATP4B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P13607", "map_id": "P13607", "name": "Atpalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002921", "map_id": "FBgn0002921", "name": "Atpalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8QI34", "map_id": "A8QI34", "name": "JYalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267363", "map_id": "FBgn0267363", "name": "JYalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDY7", "map_id": "Q9VDY7", "name": "Dmel\\CG5250", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038691", "map_id": "FBgn0038691", "name": "Dmel\\CG5250", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24046", "map_id": "Q24046", "name": "nrv1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015776", "map_id": "FBgn0015776", "name": "nrv1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3Q7", "map_id": "Q9V3Q7", "name": "JYbeta2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038690", "map_id": "FBgn0038690", "name": "JYbeta2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PDX8", "map_id": "M9PDX8", "name": "nrv3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032946", "map_id": "FBgn0032946", "name": "nrv3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KT77", "map_id": "Q7KT77", "name": "Dmel\\CG33310", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053310", "map_id": "FBgn0053310", "name": "Dmel\\CG33310", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24048", "map_id": "Q24048", "name": "nrv2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015777", "map_id": "FBgn0015777", "name": "nrv2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448436", "map_id": "none", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_156540", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_111875", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10448412", "map_id": "P22700", "name": "SERCA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10448434", "map_id": "none", "name": "CAMK2 heteromer:CALM:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q00168", "map_id": "Q00168", "name": "phospho-CaMKII", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264607", "map_id": "FBgn0264607", "name": "phospho-CaMKII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478001", "map_id": "none", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692450", "map_id": "CHEBI:36916", "name": "cation", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692484", "map_id": "CHEBI:36916", "name": "cation", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10477998", "map_id": "A8DZ26", "name": "anne", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0052000", "map_id": "FBgn0052000", "name": "anne", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448234", "map_id": "none", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448231", "map_id": "none", "name": "SLC12A1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9PI37", "map_id": "M9PI37", "name": "Ncc69", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036279", "map_id": "FBgn0036279", "name": "Ncc69", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNC7", "map_id": "Q9VNC7", "name": "NKCC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051547", "map_id": "FBgn0051547", "name": "NKCC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448243", "map_id": "none", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448240", "map_id": "none", "name": "Homologues of SLC12A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10464875", "map_id": "none", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464873", "map_id": "none", "name": "TARBP2,PRKRA RLC:duplex miRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VLW8", "map_id": "Q9VLW8", "name": "r2d2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031951", "map_id": "FBgn0031951", "name": "r2d2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJY9", "map_id": "Q9VJY9", "name": "loqs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032515", "map_id": "FBgn0032515", "name": "loqs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCU9", "map_id": "Q9VCU9", "name": "Dcr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039016", "map_id": "FBgn0039016", "name": "Dcr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q32KD4", "map_id": "Q32KD4", "name": "AGO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262739", "map_id": "FBgn0262739", "name": "AGO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10443056", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:Pre-RISC (miRNA)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10443076", "map_id": "none", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10443074", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:RISC (miRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431293", "map_id": "none", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113559", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29374", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_73871", "map_id": "CHEBI:15345", "name": "ACA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428434", "map_id": "none", "name": "ACAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9W3N9", "map_id": "Q9W3N9", "name": "154229_at", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029969", "map_id": "FBgn0029969", "name": "154229_at", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431485", "map_id": "none", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73917", "map_id": "CHEBI:15467", "name": "HMG CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_73909", "map_id": "CHEBI:15344", "name": "ACA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10431482", "map_id": "none", "name": "HMGCL dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VM58", "map_id": "Q9VM58", "name": "Hmgcl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031877", "map_id": "FBgn0031877", "name": "Hmgcl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431291", "map_id": "none", "name": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113526", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_73911", "map_id": "CHEBI:17066", "name": "bHBA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10431288", "map_id": "none", "name": "BDH1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q7K3N4", "map_id": "Q7K3N4", "name": "Dmel\\CG8888", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033679", "map_id": "FBgn0033679", "name": "Dmel\\CG8888", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491097", "map_id": "none", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113593", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113539", "map_id": "CHEBI:30089", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_159448", "map_id": "CHEBI:16027", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10491094", "map_id": "Q9VC92", "name": "Dmel\\CG6432", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0039184", "map_id": "FBgn0039184", "name": "Dmel\\CG6432", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479990", "map_id": "none", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29666", "map_id": "CHEBI:13705", "name": "ACA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479987", "map_id": "none", "name": "HMGCLL1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431301", "map_id": "none", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10431298", "map_id": "Q7K4Q9", "name": "Hmgs", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10479039", "map_id": "none", "name": "A4GNT transfers GlcNAc to core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10454881", "map_id": "none", "name": "Core 2 mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10479031", "map_id": "none", "name": "Core 2a mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10479036", "map_id": "Q9VQK4", "name": "alpha4GT1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0031491", "map_id": "FBgn0031491", "name": "alpha4GT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454637", "map_id": "none", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10454542", "map_id": "none", "name": "Mucins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10454634", "map_id": "none", "name": "GALNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9Y117", "map_id": "Q9Y117", "name": "Pgant3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027558", "map_id": "FBgn0027558", "name": "Pgant3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6WV17", "map_id": "Q6WV17", "name": "Pgant5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031681", "map_id": "FBgn0031681", "name": "Pgant5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MV48", "map_id": "Q8MV48", "name": "Pgant7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030930", "map_id": "FBgn0030930", "name": "Pgant7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6WV19", "map_id": "Q6WV19", "name": "Pgant2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031530", "map_id": "FBgn0031530", "name": "Pgant2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6WV20", "map_id": "Q6WV20", "name": "Pgant1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYY6", "map_id": "Q8MYY6", "name": "pgant13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039596", "map_id": "FBgn0039596", "name": "pgant13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MRC9", "map_id": "Q8MRC9", "name": "Pgant9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050463", "map_id": "FBgn0050463", "name": "Pgant9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MVS5", "map_id": "Q8MVS5", "name": "Pgant35A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001970", "map_id": "FBgn0001970", "name": "Pgant35A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10462333", "map_id": "none", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10462330", "map_id": "none", "name": "C1GALT1:C1GALT1C1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VQH4", "map_id": "Q9VQH4", "name": "dC1GalT7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031466", "map_id": "FBgn0031466", "name": "dC1GalT7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JNT3", "map_id": "A8JNT3", "name": "Dmel\\CG34451", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085480", "map_id": "FBgn0085480", "name": "Dmel\\CG34451", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQI0", "map_id": "Q9VQI0", "name": "Dmel\\CG2983", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031472", "map_id": "FBgn0031472", "name": "Dmel\\CG2983", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K237", "map_id": "Q7K237", "name": "C1GalTA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032078", "map_id": "FBgn0032078", "name": "C1GalTA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JNT2", "map_id": "A8JNT2", "name": "CG33999", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085481", "map_id": "FBgn0085481", "name": "CG33999", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQH7", "map_id": "Q9VQH7", "name": "Dmel\\CG18558", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031469", "map_id": "FBgn0031469", "name": "Dmel\\CG18558", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JRF9", "map_id": "Q7JRF9", "name": "Dmel\\CG8708", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033271", "map_id": "FBgn0033271", "name": "Dmel\\CG8708", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0L4", "map_id": "Q9W0L4", "name": "dC1GalT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0054056", "map_id": "FBgn0054056", "name": "dC1GalT6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQH6", "map_id": "Q9VQH6", "name": "Dmel\\CG2975", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031468", "map_id": "FBgn0031468", "name": "Dmel\\CG2975", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2PE08", "map_id": "Q2PE08", "name": "CG13904", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0054057", "map_id": "FBgn0054057", "name": "CG13904", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWM1", "map_id": "Q9VWM1", "name": "tgy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030984", "map_id": "FBgn0030984", "name": "tgy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479773", "map_id": "none", "name": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10479764", "map_id": "none", "name": "Core 2S mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10479770", "map_id": "none", "name": "Homologues of CHST4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10462269", "map_id": "none", "name": "Addition of galactose to Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10454714", "map_id": "none", "name": "Core 6 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462264", "map_id": "none", "name": "extended Core 6 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462266", "map_id": "none", "name": "B4GALT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10454716", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "reaction_10454843", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10454735", "map_id": "none", "name": "Core 3 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10454840", "map_id": "none", "name": "B3GNTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10454695", "map_id": "none", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10454693", "map_id": "none", "name": "Core 8 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10454902", "map_id": "none", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10454900", "map_id": "none", "name": "Core 7 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10454674", "map_id": "none", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10454672", "map_id": "none", "name": "Core 5 mucins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10470740", "map_id": "none", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10470732", "map_id": "none", "name": "POFUT2 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q9VM97", "map_id": "Q9VM97", "name": "Tsp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031850", "map_id": "FBgn0031850", "name": "Tsp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1Z6", "map_id": "Q9W1Z6", "name": "stl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086408", "map_id": "FBgn0086408", "name": "stl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SXB0", "map_id": "Q8SXB0", "name": "AdamTS-A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286071", "map_id": "FBgn0286071", "name": "AdamTS-A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K3Y9", "map_id": "Q7K3Y9", "name": "Dmel\\CG17739", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033710", "map_id": "FBgn0033710", "name": "Dmel\\CG17739", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W493", "map_id": "Q9W493", "name": "AdamTS-B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029791", "map_id": "FBgn0029791", "name": "AdamTS-B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470564", "map_id": "none", "name": "O-fuc-proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10470737", "map_id": "Q9W589", "name": "O-fut2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0027791", "map_id": "FBgn0027791", "name": "O-fut2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470658", "map_id": "none", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_173594", "map_id": "CHEBI:18066", "name": "UDP-Glc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_158602", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10470650", "map_id": "none", "name": "glc-fuc-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10470655", "map_id": "X2JDC2", "name": "Dmel\\CG9109", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0031765", "map_id": "FBgn0031765", "name": "Dmel\\CG9109", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449358", "map_id": "none", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10449355", "map_id": "none", "name": "Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7KRY7", "map_id": "Q7KRY7", "name": "scrib", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263289", "map_id": "FBgn0263289", "name": "scrib", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16523", "map_id": "CHEBI:16523", "name": "CHEBI:16523", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9635195", "map_id": "none", "name": "Ifenprodil", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10449740", "map_id": "none", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10446948", "map_id": "none", "name": "Ca impermeable AMPA receptor ligand complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10449738", "map_id": "none", "name": "Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10497396", "map_id": "none", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10497390", "map_id": "Q24418", "name": "Nmdar1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10497392", "map_id": "Q9W581", "name": "Nmdar2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10497394", "map_id": "none", "name": "GRIN1:GRIN2A di-heterotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10497508", "map_id": "none", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10497506", "map_id": "none", "name": "GRIN1:GRIN2A,C,D di-heteromers, GRIN1:GRIN2 tri-heteromers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10449322", "map_id": "none", "name": "GRIN1:GRIN2A,C,D di-heteromers,GRIN1:GRIN2 tri-heteromers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10493706", "map_id": "none", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434305", "map_id": "none", "name": "PKA tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10434269", "map_id": "none", "name": "CAMK4 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434260", "map_id": "none", "name": "p-T200-CAMK4:CALM1:4xCa2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7PLI7", "map_id": "Q7PLI7", "name": "phospho-p-T200-CAMK4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261387", "map_id": "FBgn0261387", "name": "phospho-p-T200-CAMK4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434266", "map_id": "none", "name": "p-S12.S13,T200-CAMK4:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10435620", "map_id": "none", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435618", "map_id": "none", "name": "mRNA:eIF4F:eIF4B:eIF4H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "X2JC79", "map_id": "X2JC79", "name": "eIF4H1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262734", "map_id": "FBgn0262734", "name": "eIF4H1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02748", "map_id": "Q02748", "name": "eIF4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001942", "map_id": "FBgn0001942", "name": "eIF4A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCH1", "map_id": "Q9VCH1", "name": "eIF4G2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260634", "map_id": "FBgn0260634", "name": "eIF4G2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DZ29", "map_id": "A8DZ29", "name": "eIF4G1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023213", "map_id": "FBgn0023213", "name": "eIF4G1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10430440", "map_id": "Q9VEA1", "name": "eIF1A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430508", "map_id": "none", "name": "48S complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10435555", "map_id": "none", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435546", "map_id": "none", "name": "Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10435551", "map_id": "P21187", "name": "pAbp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0265297", "map_id": "FBgn0265297", "name": "pAbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435553", "map_id": "none", "name": "43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P21187", "map_id": "P21187", "name": "pAbp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497375", "map_id": "none", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10497365", "map_id": "Q7KU08", "name": "wry", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0051665", "map_id": "FBgn0051665", "name": "phospho-wry", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10443303", "map_id": "Q7KU08", "name": "wry", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10497373", "map_id": "none", "name": "p-4S-NICD4:YWHAZ dimer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KU08", "map_id": "Q7KU08", "name": "phospho-wry", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446682", "map_id": "none", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445670", "map_id": "P16395", "name": "mAChR-A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0000037", "map_id": "FBgn0000037", "name": "mAChR-A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_390899", "map_id": "CHEBI:18295", "name": "Hist", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10445672", "map_id": "none", "name": "HRH4:Hist", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P16395", "map_id": "P16395", "name": "mAChR-A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498568", "map_id": "none", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10498564", "map_id": "P16395", "name": "mAChR-A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10498566", "map_id": "none", "name": "HRH3:Hist", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496054", "map_id": "none", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496029", "map_id": "none", "name": "RUNX2:STUB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XYW6", "map_id": "Q9XYW6", "name": "STUB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PI08", "map_id": "M9PI08", "name": "RunxA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0083981", "map_id": "FBgn0083981", "name": "RunxA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22814", "map_id": "P22814", "name": "run", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003300", "map_id": "FBgn0003300", "name": "run", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRA9", "map_id": "Q9VRA9", "name": "RunxB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259162", "map_id": "FBgn0259162", "name": "RunxB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W349", "map_id": "Q9W349", "name": "lz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002576", "map_id": "FBgn0002576", "name": "lz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496051", "map_id": "none", "name": "PolyUb-RUNX2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10492551", "map_id": "none", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492520", "map_id": "none", "name": "RUNX2:SCF(SKP2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427449", "map_id": "none", "name": "SCF (SKP2) complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492548", "map_id": "none", "name": "PolyUb-RUNX2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496056", "map_id": "none", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496027", "map_id": "none", "name": "RUNX2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10492553", "map_id": "none", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10492522", "map_id": "none", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491656", "map_id": "none", "name": "RUNX2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_538904", "map_id": "none", "name": "Phosphorylated PER binds to CLK", "reversible": "false", "notes": "After Timeless (TIM) and Period (PER) reform their heterodimer, PER binds to the E-box bound Clock (CLK) protein. Transcription of the per, tim, vri, and Pdp1 target genes is now deactivated. It appears that PER directly binds to CLK, whereas itself and TIM do not bind to Cycle (CYC). PER binding to CLK is in itself not sufficient for inhibition.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_881986", "map_id": "none", "name": "DNA:CLK:CYC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O61735", "map_id": "O61735", "name": "Phospho CLK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho CLK", "map_id": "Phospho CLK", "name": "Phospho CLK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61734", "map_id": "O61734", "name": "CYC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CYC", "map_id": "CYC", "name": "CYC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_881995", "map_id": "none", "name": "Phospho TIM:Phospho (multi-site 2) PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P07663", "map_id": "P07663", "name": "Phospho (multi-site 2) PER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho (multi-site 2) PER", "map_id": "Phospho (multi-site 2) PER", "name": "Phospho (multi-site 2) PER", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49021", "map_id": "P49021", "name": "TIM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "TIM", "map_id": "TIM", "name": "TIM", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_882012", "map_id": "none", "name": "Phospho TIM:DNA:CLK:CYC:Phospho (multi-site 2) PER:DCO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_538891", "map_id": "none", "name": "CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes", "reversible": "false", "notes": "The deactivation of the Clock (CLK):Cycle (CYC) heterodimer and subsequent deactivation of the per, tim, vri, and Pdp1 target genes causes the CLK:CYC heterodimer to be released from its binding to its target genes, sequestered in a stable complex with PER and TIM to reinforce the transcription inhibition. Towards the end of the night Period (PER) and Timeless (TIM) proteins are at their peak level.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_881925", "map_id": "none", "name": "Phospho TIM:DNA:Phospho CLK:CYC:Phospho (multi-site 2) PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_881962", "map_id": "none", "name": "Phospho TIM:Phospho CLK:CYC:Phospho (multi-site 2) PER:DCO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_29428", "map_id": "none", "name": "DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_432513", "map_id": "none", "name": "CLK is phosphorylated by DCO", "reversible": "false", "notes": "Clock (CLK) protein is now phosphorylated on unknown serine/threonine residues by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO). It is not yet known whether other kinases are involved in phosphorylating CLK, potentially brought to there via interactions with DCO and Period (PER) acting as scaffolding proteins. There is also evidence from mammalian systems that chromatin remodelling factors are brought in by the PER scaffold and are responsible for a sustained state of transcription inhibition in these genes.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_432381", "map_id": "none", "name": "PDP1 replaces VRI as binder to Clk and cry genes", "reversible": "false", "notes": "PAR domain protein-1 (PDP1) levels reach their peak between mid to late night. Vrille (VRI) levels decline during this time due to TIM:PER:DCO mediated repression of Clock (CLK) driven vri transcription. The decreasing ratio of VRI/PDP1 levels favours binding of PDP1 over VRI to the V/P boxes resulting in activation of Clk and cry transcription.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_881990", "map_id": "none", "name": "DNA:VRI", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VMS4", "map_id": "Q9VMS4", "name": "VRI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "VRI", "map_id": "VRI", "name": "VRI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_432423", "map_id": "Q24217", "name": "PDP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_432467", "map_id": "Q9VMS4", "name": "VRI", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_881966", "map_id": "none", "name": "DNA:PDP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24217", "map_id": "Q24217", "name": "PDP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PDP1", "map_id": "PDP1", "name": "PDP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_538900", "map_id": "none", "name": "Phosphorylated PER rebinds to phosphorylated TIM", "reversible": "false", "notes": "Once in the nucleus, phosphorylated Timeless (TIM) and Period (PER) reform their heterodimer.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_881991", "map_id": "none", "name": "Phospho (multi-site 2) PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_432657", "map_id": "P49021", "name": "Phospho TIM", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_432516", "map_id": "none", "name": "CLK and CYC bind to form a heterodimer", "reversible": "false", "notes": "The basic-helix-loop-helix PAS (PER-ARNT-SIM) domain transcription factors, Clock (CLK) and Cycle (CYC) bind and form a heterodimer.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_432489", "map_id": "O61734", "name": "CYC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_432557", "map_id": "O61735", "name": "CLK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_432591", "map_id": "none", "name": "CLK:CYC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_432436", "map_id": "none", "name": "CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes", "reversible": "false", "notes": "At midday, the Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target genes, per, tim, vri, and Pdp1. Transcription of these genes is now activated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_432593", "map_id": "none", "name": "Cytosolic JET binds to CRY, facilitating its ubiquitination", "reversible": "false", "notes": "After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY), facilitating its ubiquitination, marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_432571", "map_id": "Q8T0E8", "name": "JET", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_432574", "map_id": "O77059", "name": "CRY", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_432576", "map_id": "none", "name": "UBI-P63E:CRY:JET", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O77059", "map_id": "O77059", "name": "CRY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CRY", "map_id": "CRY", "name": "CRY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T0E8", "map_id": "Q8T0E8", "name": "JET", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "JET", "map_id": "JET", "name": "JET", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_432428", "map_id": "none", "name": "Cytosolic CRY is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated cryptochrome (CRY) is degraded by the 26S proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_432652", "map_id": "none", "name": "Nuclear CRY is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated cryptochrome (CRY) is degraded by the 26S proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_432418", "map_id": "none", "name": "UBI-P63E:CRY:JET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_432393", "map_id": "Q8T0E8", "name": "JET", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_432378", "map_id": "none", "name": "Nuclear JET binds CRY, facilitating its ubiquitination", "reversible": "false", "notes": "After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY), facilitating its ubiquitination and marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_432582", "map_id": "O77059", "name": "CRY", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_432510", "map_id": "none", "name": "CLK is degraded by the 26S proteasome", "reversible": "false", "notes": "Hyperphosphorylated Clock (CLK) is degraded by the 26S proteasome via an unknown intermediate mechanism.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_432621", "map_id": "none", "name": "Phospho CLK:CYC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_432455", "map_id": "none", "name": "Nuclear PER is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Period (PER) is degraded by the 26S proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_882001", "map_id": "none", "name": "Phospho CLK:CYC:SLMB:UBI-P63E:Phospho (multi-site 2) PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_432399", "map_id": "O76324", "name": "DCO", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_432469", "map_id": "O44382", "name": "SLMB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_432483", "map_id": "none", "name": "SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination", "reversible": "false", "notes": "During the day, with levels of its stabilising partner Timeless (TIM) drastically reduced by light, hyperphosphorylated Period (PER) becomes a target for the F-box containing protein, supernumerary limbs (SLMB). Ser47 phosphorylation of Period (PER) appears to be the trigger for SLMB to bind phosphorylated PER, facilitating its ubiquitination and marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for PER degradation are the same.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_881927", "map_id": "none", "name": "Phospho CLK:CYC:Phospho (multi-site 2) PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_432411", "map_id": "none", "name": "SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination", "reversible": "false", "notes": "During the day, with levels of its stabilising partner Timeless (TIM) drastically reduced by light, hyperphosphorylated Period (PER) becomes a target for the F-box containing protein, supernumerary limbs (SLMB). Ser47 phosphorylation of Period (PER) appears to be the trigger for SLMB to bind and facilitate ubiquitination of phosphorylated PER, marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for PER degradation are the same.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_881987", "map_id": "none", "name": "Phospho (multi-site 1) PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206299", "map_id": "O44382", "name": "SLMB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_881958", "map_id": "none", "name": "SLMB:UBI-P63E:Phospho (multi-site 1) PER:DCO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_432361", "map_id": "none", "name": "Cytosolic PER is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Period (PER) is degraded by the 26S proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_205729", "map_id": "O76324", "name": "DCO", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_432527", "map_id": "none", "name": "Nuclear PP2A dephosphorylates phosphorylated PER", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Widerborst (WDB), helps stabilise hyperphosphorylated Period (PER) by dephosphorylating it and so prevent it from degradation. PP2A also seems to speed up nuclear import of PER. This is probably a secondary effect of stabilising PER.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_881965", "map_id": "none", "name": "Phospho TIM:Phospho CLK:CYC:PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_432603", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VB23", "map_id": "Q9VB23", "name": "WDB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WDB", "map_id": "WDB", "name": "WDB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_432556", "map_id": "none", "name": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Twins (TWS), helps stabilise hyperphosphorylated Period (PER), within the PER:DCO complex, by dephosphorylating it and so prevent it from degradation. PP2A likely dephosphorylates the site phosphorylated by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) as it stabilises PER.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_432347", "map_id": "none", "name": "PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206938", "map_id": "none", "name": "PP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_538822", "map_id": "none", "name": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Twins (TWS), helps stabilise hyperphosphorylated Period (PER), within the PER:DCO complex, by dephosphorylating it and so prevent it from degradation. PP2A likely dephosphorylates the site phosphorylated by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) as it stabilises PER.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_881967", "map_id": "none", "name": "TIM:Phospho (multi-site 1) PER:DCO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_432413", "map_id": "none", "name": "TIM:PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_538824", "map_id": "none", "name": "PP1 binds to phosphorylated TIM in complex with PER", "reversible": "false", "notes": "The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_881944", "map_id": "none", "name": "Phospho TIM:Phospho (multi-site 2) PER:DCO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_432645", "map_id": "none", "name": "PP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q05547", "map_id": "Q05547", "name": "PP1-13C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PP1-13C", "map_id": "PP1-13C", "name": "PP1-13C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48461", "map_id": "P48461", "name": "PP1alpha-96A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PP1alpha-96A", "map_id": "PP1alpha-96A", "name": "PP1alpha-96A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P12982", "map_id": "P12982", "name": "PP1-87B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PP1-87B", "map_id": "PP1-87B", "name": "PP1-87B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_882002", "map_id": "none", "name": "PP1:Phospho TIM:Phospho (multi-site 2) PER:DCO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_432533", "map_id": "none", "name": "PP1 binds to phosphorylated TIM", "reversible": "false", "notes": "The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_432363", "map_id": "P49021", "name": "Phospho TIM", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_432543", "map_id": "none", "name": "Phospho TIM:PP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_538832", "map_id": "none", "name": "PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO", "reversible": "false", "notes": "The protein phosphatase, PP1, dephosphorylates and stabilises Timeless (TIM) which helps promote the accumulation of Period (PER).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_881912", "map_id": "none", "name": "TIM:Phospho (multi-site 2) PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_432427", "map_id": "none", "name": "PP1 dephosphorylates phosphorylated TIM", "reversible": "false", "notes": "The protein phosphatase, PP1, dephosphorylates and stabilises Timeless (TIM) which helps promote the accumulation of Period (PER).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_432355", "map_id": "P49021", "name": "TIM", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_432642", "map_id": "none", "name": "Phosphorylated TIM transports from the cytosol to the nucleus", "reversible": "false", "notes": "After the phosphorylated Period (PER):Discs Overgrown (DCO) complex has entered the nucleus, phosphorylated Timeless (TIM) does the same. The time frame between the two events appears to be variable, depending on the type of neuronal clock cell, and can be up to a few hours later. It is currently not known whether casein kinase II (CK2) is bound to PER and/or TIM and whether it travels with either from the cytosol to the nucleus.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_432544", "map_id": "none", "name": "Phosphorylated PER transports from the cytosol to the nucleus", "reversible": "false", "notes": "Phosphorylated Period (PER):Discs Overgrown (DCO) complex is imported into the nucleus from the cytosol.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_882007", "map_id": "none", "name": "Phospho (multi-site 2) PER:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_432371", "map_id": "none", "name": "CRY is activated by light and binds to phosphorylated nuclear TIM", "reversible": "false", "notes": "At dawn, a light-induced conformational change in the blue-light photoreceptor cryptochrome (CRY) promotes the formation of a complex with phosphorylated Timeless (TIM). In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for TIM degradation are the same. Also, in flies kept in constant darkness for many days, TIM levels still undergo daily oscillations, although not as robust as in light-dark cycles. The mechanism that drives daily cycles in TIM levels during extended periods in complete darkness is not clear.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_881922", "map_id": "none", "name": "Phospho TIM:CRY", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_432508", "map_id": "CHEBI:30212", "name": "Photon", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_432401", "map_id": "none", "name": "JET binds cytosolic TIM, facilitating its ubiquitination", "reversible": "false", "notes": "There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and TIM helps promote the interaction between the F-box domain containing protein JET with TIM. This interaction targets TIM for ubiquitination, marking it for processing by the 26S proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_881918", "map_id": "none", "name": "TIM:CRY", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_881984", "map_id": "none", "name": "UBI-P63E:TIM:JET", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_432426", "map_id": "none", "name": "CRY is activated by light and binds to cytosolic TIM", "reversible": "false", "notes": "At dawn, a light-induced conformational change in the blue-light photoreceptor cryptochrome (CRY) promotes the formation of a complex with Timeless (TIM). In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for TIM degradation are the same. Also, in flies kept in constant darkness for many days, TIM levels still undergo daily oscillations, although not as robust as in light-dark cycles. The mechanism that drives daily cycles in TIM levels during extended periods in complete darkness is not clear.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_432604", "map_id": "CHEBI:30212", "name": "Photon", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_432507", "map_id": "none", "name": "Cytosolic TIM is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_432424", "map_id": "none", "name": "JET binds phosphorylated nuclear TIM, facilitating its ubiquitination", "reversible": "false", "notes": "There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and phosphorylated TIM helps promote the interaction between the F-box domain containing protein JET with phosphorylated TIM, facilitating ubiquitination of the latter protein, marking it for processing by the 26S proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_882000", "map_id": "none", "name": "UBI-P63E:Phospho TIM:JET", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_432521", "map_id": "none", "name": "Nuclear TIM is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_432487", "map_id": "none", "name": "CWO binds to cwo gene and represses transcription", "reversible": "false", "notes": "Clockwork Orange (CWO) binds to the E-box of its own gene, cwo, and represses it's own transcription in a negative feedback loop.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_432566", "map_id": "Q9VGZ5", "name": "CWO", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_881926", "map_id": "none", "name": "DNA:CWO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VGZ5", "map_id": "Q9VGZ5", "name": "CWO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CWO", "map_id": "CWO", "name": "CWO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_432520", "map_id": "none", "name": "CLK:CYC heterodimer binds to cwo gene and activates transcription", "reversible": "false", "notes": "The Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target gene, cwo. Transcription of cwo is now activated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_432647", "map_id": "none", "name": "Phosphorylated PER binds to TIM", "reversible": "false", "notes": "After dusk, per and tim genes continue to be transcribed and their mRNAs reach peak levels between during the early part of the night. Timeless (TIM) protein is stable in the dark and so begins to accumulate and forms a complex with Period (PER) and Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). TIM stabilises PER despite the continuous attentions of casein kinase II (CK2) and DCO. As a result, PER and TIM accumulate to high levels during the middle of the night.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_432535", "map_id": "none", "name": "TIM is phosphorylated by CK2", "reversible": "false", "notes": "Timeless (TIM) is phosphorylated on unknown serine/threonine residues by casein kinase II (CK2). CK2 phosphorylation appears to be important for subsequent nuclear entry of TIM.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206956", "map_id": "none", "name": "RAS85D:GTP:SRC42A:Phospho CNK:14-3-3epsilon dimer:Phospho PHL:Phospho KSR:14-3-3epsilon dimer:AVE:DSOR1:CK2:PAR-1:PP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7KNQ9", "map_id": "Q7KNQ9", "name": "cnk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "cnk", "map_id": "cnk", "name": "cnk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95U75", "map_id": "Q95U75", "name": "PAR-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PAR-1", "map_id": "PAR-1", "name": "PAR-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9J3", "map_id": "Q9V9J3", "name": "phospho-Src42A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-Src42A", "map_id": "phospho-Src42A", "name": "phospho-Src42A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ML92", "map_id": "Q8ML92", "name": "AVE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "AVE", "map_id": "AVE", "name": "AVE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24170", "map_id": "Q24170", "name": "Phospho KSR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho KSR", "map_id": "Phospho KSR", "name": "Phospho KSR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_432464", "map_id": "none", "name": "Phosphorylated TIM:PER heterodimer dissociate", "reversible": "false", "notes": "The phosphorylation of Timeless (TIM) and Period (PER) by casein kinase II (CK2) appears to be the trigger for their nuclear entry. However, before this occurs, phosphorylated TIM dissociates from the PER:Discs Overgrown (DCO) complex.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_432590", "map_id": "none", "name": "Phosphorylated PER is phosphorylated by CK2", "reversible": "false", "notes": "Phosphorylated Period (PER) is phosphorylated on serine residues 149, 151, 153, by casein kinase II (CK2). CK2 phosphorylation appears to be important for subsequent nuclear entry of PER.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_432559", "map_id": "none", "name": "PER is phosphorylated by DCO", "reversible": "false", "notes": "Period (PER) is phosphorylated on between 15-20 individual serine and threonine sites by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). During the day, when light activated regulation of Timeless (TIM) occurs and its levels are low, phosphorylated PER is susceptible to supernumerary limbs (SLMB) mediated ubiquitination and degradation. Ser47 and possibly other phosphorylated residues nearby are key phospho-signals on PER mediating the binding of SLMB to PER.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206741", "map_id": "none", "name": "AXN:APC:PP2A:CKIalpha:DCO:SGG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_881988", "map_id": "none", "name": "CRY is phosphorylated by SGG", "reversible": "false", "notes": "The blue-light photoreceptor cryptochrome (CRY) is phosphorylated on unknown serine/threonine residues by GSK3beta kinase orthologue, Shaggy (SGG). Phosphorylation appears to attenuate the function of CRY and it doesn't degrade Timeless (TIM). Earlier studies suggested that the effect of SGG on the light-mediated degradation of TIM was due to direct phosphorylation of TIM by SGG (Martinek et al., 2001), however, more recent experiments suggest the actual target of SGG in this pathway is CRY (Storelu et al., 2007).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_882013", "map_id": "O77059", "name": "Phospho CRY", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206898", "map_id": "none", "name": "Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_538835", "map_id": "none", "name": "PER binds to DCO", "reversible": "false", "notes": "The Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT) forms a complex with Period (PER).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_432515", "map_id": "P07663", "name": "PER", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_432537", "map_id": "none", "name": "PP2A dephosphorylates phosphorylated CLK", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Widerborst (WDB), helps stabilise hyperphosphorylated Clock (CLK) by dephosphorylating it and so prevent it from degradation. CLK levels remain relatively constant because hypophosphorylated CLK is generated by de novo synthesis or by dephosphorylation of existent hyperphosphorylated CLK.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10456268", "map_id": "none", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437245", "map_id": "none", "name": "C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VLY7", "map_id": "Q9VLY7", "name": "Tep3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041181", "map_id": "FBgn0041181", "name": "Tep3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLT3", "map_id": "Q9VLT3", "name": "Mcr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267488", "map_id": "FBgn0267488", "name": "Mcr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NFV8", "map_id": "Q9NFV8", "name": "Tep1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041183", "map_id": "FBgn0041183", "name": "Tep1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NFV7", "map_id": "Q9NFV7", "name": "Tep2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041182", "map_id": "FBgn0041182", "name": "Tep2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PDR0", "map_id": "M9PDR0", "name": "Tep4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041180", "map_id": "FBgn0041180", "name": "Tep4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10456122", "map_id": "none", "name": "Cell surface:C4b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10456252", "map_id": "none", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437285", "map_id": "none", "name": "C3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10456083", "map_id": "none", "name": "Cell surface:C3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10438059", "map_id": "none", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10437271", "map_id": "none", "name": "Complement factor 3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10438057", "map_id": "none", "name": "C3(H2O)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10431519", "map_id": "none", "name": "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500172", "map_id": "none", "name": "Ino, dI", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28997", "map_id": "CHEBI:28997", "name": "CHEBI:28997", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_83927", "map_id": "CHEBI:17596", "name": "Ino", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_113599", "map_id": "CHEBI:17368", "name": "Hyp", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_500244", "map_id": "none", "name": "R1P, dRibP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28542", "map_id": "CHEBI:28542", "name": "CHEBI:28542", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_112016", "map_id": "CHEBI:35425", "name": "R1P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10431516", "map_id": "none", "name": "NP trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W1K6", "map_id": "Q9W1K6", "name": "Dmel\\CG18128", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034898", "map_id": "FBgn0034898", "name": "Dmel\\CG18128", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PE19", "map_id": "M9PE19", "name": "CG16760", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035348", "map_id": "FBgn0035348", "name": "CG16760", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431551", "map_id": "none", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83956", "map_id": "CHEBI:16235", "name": "Gua", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30064", "map_id": "CHEBI:17712", "name": "XAN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431548", "map_id": "none", "name": "GDA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VMY9", "map_id": "Q9VMY9", "name": "DhpD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261436", "map_id": "FBgn0261436", "name": "DhpD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431529", "map_id": "none", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431526", "map_id": "none", "name": "XDH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:44074", "map_id": "CHEBI:44074", "name": "CHEBI:44074", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P10351", "map_id": "P10351", "name": "ry", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003308", "map_id": "FBgn0003308", "name": "ry", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466119", "map_id": "none", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509835", "map_id": "CHEBI:28807", "name": "dITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_109330", "map_id": "CHEBI:28806", "name": "dIMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10466110", "map_id": "none", "name": "ITPA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VMW7", "map_id": "Q9VMW7", "name": "ITPA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031663", "map_id": "FBgn0031663", "name": "ITPA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431541", "map_id": "none", "name": "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500245", "map_id": "none", "name": "G, dG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:17172", "map_id": "CHEBI:17172", "name": "CHEBI:17172", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16750", "map_id": "CHEBI:16750", "name": "CHEBI:16750", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465661", "map_id": "none", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395883", "map_id": "CHEBI:63728", "name": "8-oxo-dGDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395817", "map_id": "CHEBI:63223", "name": "8-oxo-dGMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465656", "map_id": "Q9VGM4", "name": "Dmel\\CG10898", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0037911", "map_id": "FBgn0037911", "name": "Dmel\\CG10898", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465659", "map_id": "none", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395880", "map_id": "CHEBI:65134", "name": "8-oxo-GDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395877", "map_id": "CHEBI:65135", "name": "8-oxo-GMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465590", "map_id": "none", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2393945", "map_id": "CHEBI:16960", "name": "ADP-Rib", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2393950", "map_id": "CHEBI:17797", "name": "R5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10465587", "map_id": "none", "name": "NUDT9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VV83", "map_id": "Q9VV83", "name": "CG4098-PA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036648", "map_id": "FBgn0036648", "name": "CG4098-PA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465664", "map_id": "none", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2395963", "map_id": "CHEBI:70963", "name": "8-hydroxy-dADP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2395964", "map_id": "CHEBI:70964", "name": "8-hydroxy-dAMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10466116", "map_id": "none", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509848", "map_id": "CHEBI:10049", "name": "XTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111584", "map_id": "CHEBI:15652", "name": "XMP", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433331", "map_id": "none", "name": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_500101", "map_id": "none", "name": "AMP, dAMP, GMP, IMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29602", "map_id": "CHEBI:17202", "name": "IMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_109386", "map_id": "CHEBI:17713", "name": "2'-deoxyadenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_500104", "map_id": "none", "name": "Ade-Rib, dA, Gua-Rib, Ino", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_83908", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "CHEBI:17256", "map_id": "CHEBI:17256", "name": "CHEBI:17256", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10433328", "map_id": "none", "name": "NT5E:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8SZY4", "map_id": "Q8SZY4", "name": "NT5E-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050104", "map_id": "FBgn0050104", "name": "NT5E-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431539", "map_id": "none", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500120", "map_id": "none", "name": "(d)GMP, (d)IMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16192", "map_id": "CHEBI:16192", "name": "CHEBI:16192", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500118", "map_id": "none", "name": "Gu-Rib, dG, Ino, dI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10431536", "map_id": "none", "name": "NT5C2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VWV5", "map_id": "Q9VWV5", "name": "24643014", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052549", "map_id": "FBgn0052549", "name": "24643014", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431553", "map_id": "none", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30034", "map_id": "CHEBI:17775", "name": "urate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10466113", "map_id": "none", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2509836", "map_id": "CHEBI:16039", "name": "ITP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465084", "map_id": "none", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265283", "map_id": "CHEBI:15554", "name": "PGH2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_879629", "map_id": "CHEBI:15555", "name": "PGD2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465081", "map_id": "none", "name": "HPGDS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P41043", "map_id": "P41043", "name": "GstS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010226", "map_id": "FBgn0010226", "name": "GstS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10443627", "map_id": "none", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265287", "map_id": "CHEBI:15551", "name": "PGE2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10443624", "map_id": "none", "name": "PTGES2(88-377), PTGES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VH95", "map_id": "Q9VH95", "name": "PTGES3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037728", "map_id": "FBgn0037728", "name": "PTGES3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V420", "map_id": "Q9V420", "name": "Su(P)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004465", "map_id": "FBgn0004465", "name": "Su(P)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465079", "map_id": "none", "name": "PGH2 is isomerised to PGE2 by PTGES", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10465076", "map_id": "none", "name": "PTGES trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8SY19", "map_id": "Q8SY19", "name": "Mgstl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025814", "map_id": "FBgn0025814", "name": "Mgstl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B54", "map_id": "Q86B54", "name": "Dmel\\CG33177", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053177", "map_id": "FBgn0053177", "name": "Dmel\\CG33177", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2JF29", "map_id": "X2JF29", "name": "CG5579", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053178", "map_id": "FBgn0053178", "name": "CG5579", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465060", "map_id": "none", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142710", "map_id": "CHEBI:27595", "name": "11epi-PGF2a", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465057", "map_id": "none", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_879535", "map_id": "CHEBI:15553", "name": "PGF2a", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10474576", "map_id": "none", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474566", "map_id": "none", "name": "PAR-PARP1,PAR-PARP2 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P35875", "map_id": "P35875", "name": "Parp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010247", "map_id": "FBgn0010247", "name": "Parp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5651834", "map_id": "CHEBI:16960", "name": "ADP-D-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10474568", "map_id": "none", "name": "PARP1,PARP2 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10474573", "map_id": "O46043", "name": "Parg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0023216", "map_id": "FBgn0023216", "name": "Parg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433082", "map_id": "none", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433079", "map_id": "none", "name": "AMPD tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "X2JEY5", "map_id": "X2JEY5", "name": "AMPdeam", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052626", "map_id": "FBgn0052626", "name": "AMPdeam", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431497", "map_id": "none", "name": "Adenine + PRPP => AMP + PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73566", "map_id": "CHEBI:17111", "name": "PRPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_83951", "map_id": "CHEBI:16708", "name": "Ade", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10431494", "map_id": "none", "name": "APRT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P12426", "map_id": "P12426", "name": "Aprt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000109", "map_id": "FBgn0000109", "name": "Aprt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465047", "map_id": "none", "name": "N6-methyl-AMP + H2O => IMP + methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161190", "map_id": "CHEBI:40196", "name": "N6-methyl-AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161177", "map_id": "CHEBI:16830", "name": "methylamine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465044", "map_id": "none", "name": "ADAL:Zn", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VHH7", "map_id": "Q9VHH7", "name": "Ada", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037661", "map_id": "FBgn0037661", "name": "Ada", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433411", "map_id": "none", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500173", "map_id": "none", "name": "Ade-Rib, dA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500088", "map_id": "none", "name": "(d)AMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433408", "map_id": "none", "name": "ADK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VU38", "map_id": "Q9VU38", "name": "Adk2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283494", "map_id": "FBgn0283494", "name": "Adk2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458882", "map_id": "none", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458879", "map_id": "none", "name": "TRESK homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W2L7", "map_id": "Q9W2L7", "name": "CG15655", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085425", "map_id": "FBgn0085425", "name": "CG15655", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10456063", "map_id": "none", "name": "PHGHD tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_977329", "map_id": "CHEBI:30933", "name": "3POPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10456060", "map_id": "none", "name": "PHGHD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VKI8", "map_id": "Q9VKI8", "name": "GH26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032350", "map_id": "FBgn0032350", "name": "GH26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10456042", "map_id": "none", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_936706", "map_id": "CHEBI:15811", "name": "O-P-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10456039", "map_id": "none", "name": "PSPH:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSY6", "map_id": "Q9VSY6", "name": "aay", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023129", "map_id": "FBgn0023129", "name": "aay", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491958", "map_id": "none", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8932979", "map_id": "CHEBI:33384", "name": "L-Ser", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10491947", "map_id": "M9PFR2", "name": "Serinc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0028399", "map_id": "FBgn0028399", "name": "Serinc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10456053", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29404", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10456050", "map_id": "none", "name": "PXLP-K200-PSAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VAN0", "map_id": "Q9VAN0", "name": "PXLP-K200-PSAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014427", "map_id": "FBgn0014427", "name": "PXLP-K200-PSAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469871", "map_id": "none", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469863", "map_id": "Q9VGI8", "name": "Blm", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0002906", "map_id": "FBgn0002906", "name": "Blm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469869", "map_id": "Q9VGI8", "name": "Blm", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469853", "map_id": "none", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465325", "map_id": "P35875", "name": "Parp", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10469851", "map_id": "P35875", "name": "Parp", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10469560", "map_id": "A1Z7P5", "name": "Su(var)2-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469847", "map_id": "none", "name": "SUMOylation of TDG with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433855", "map_id": "Q9V4D8", "name": "Thd1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0026869", "map_id": "FBgn0026869", "name": "Thd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469845", "map_id": "Q9V4D8", "name": "Thd1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469893", "map_id": "none", "name": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469883", "map_id": "none", "name": "Homologues of CETN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8T415", "map_id": "Q8T415", "name": "CG15158", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051802", "map_id": "FBgn0051802", "name": "CG15158", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PGG8", "map_id": "M9PGG8", "name": "Dmel\\CG17493", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040010", "map_id": "FBgn0040010", "name": "Dmel\\CG17493", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469891", "map_id": "none", "name": "Homologues of SUMO2,3-CETN2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10469936", "map_id": "none", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469926", "map_id": "none", "name": "Homologues of MDC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95RC8", "map_id": "Q95RC8", "name": "mu2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002872", "map_id": "FBgn0002872", "name": "mu2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUB7", "map_id": "Q9VUB7", "name": "Ptip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052133", "map_id": "FBgn0052133", "name": "Ptip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469934", "map_id": "none", "name": "Homologues of SUMO2,3-K1840-MDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10469840", "map_id": "none", "name": "SUMOylation of RPA1 (RPA70) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427308", "map_id": "Q24492", "name": "RpA-70", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10469838", "map_id": "Q24492", "name": "RpA-70", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10435033", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane" }, { "id": "species_10435030", "map_id": "none", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "P29993", "map_id": "P29993", "name": "Itpr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010051", "map_id": "FBgn0010051", "name": "Itpr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473205", "map_id": "none", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447516", "map_id": "Q27571", "name": "Nos", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10447500", "map_id": "Q59DP9", "name": "PMCA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10473203", "map_id": "none", "name": "ATP2B4:NOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q59DP9", "map_id": "Q59DP9", "name": "PMCA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464851", "map_id": "none", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464846", "map_id": "none", "name": "STIM1:TRPC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VJJ7", "map_id": "Q9VJJ7", "name": "Trpgamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032593", "map_id": "FBgn0032593", "name": "Trpgamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48994", "map_id": "P48994", "name": "trpl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005614", "map_id": "FBgn0005614", "name": "trpl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P19334", "map_id": "P19334", "name": "trp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003861", "map_id": "FBgn0003861", "name": "trp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P83094", "map_id": "P83094", "name": "Stim", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Stim", "map_id": "Stim", "name": "Stim", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471073", "map_id": "none", "name": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10457748", "map_id": "none", "name": "ITPR:I(1,4,5)P3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10471069", "map_id": "none", "name": "AHCYL1:NAD+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VZX9", "map_id": "Q9VZX9", "name": "AhcyL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035371", "map_id": "FBgn0035371", "name": "AhcyL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P50245", "map_id": "P50245", "name": "AhcyL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015011", "map_id": "FBgn0015011", "name": "AhcyL2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471071", "map_id": "none", "name": "AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10473217", "map_id": "none", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473210", "map_id": "P36188", "name": "wupA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0283471", "map_id": "FBgn0283471", "name": "phospho-wupA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473214", "map_id": "P36188", "name": "phospho-wupA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10434289", "map_id": "P12370", "name": "Pka-C1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10466954", "map_id": "none", "name": "NFKB1:RELA translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10441907", "map_id": "none", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441582", "map_id": "P83099", "name": "Pkcdelta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441905", "map_id": "none", "name": "PKC-theta (open): DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10472898", "map_id": "none", "name": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472896", "map_id": "none", "name": "K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10466833", "map_id": "none", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441891", "map_id": "none", "name": "p-Y90-PKC-theta:DAG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10466831", "map_id": "none", "name": "p-5Y-PKC-theta:DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458269", "map_id": "none", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237176", "map_id": "CHEBI:58828", "name": "2,3-DMPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237155", "map_id": "CHEBI:58795", "name": "Acireductone", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458266", "map_id": "none", "name": "E1:Mg++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VN95", "map_id": "Q9VN95", "name": "ENOPH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037305", "map_id": "FBgn0037305", "name": "ENOPH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458249", "map_id": "none", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237165", "map_id": "CHEBI:58533", "name": "MTRIBP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237107", "map_id": "CHEBI:58548", "name": "MTRIBUP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458246", "map_id": "Q9V9X4", "name": "MRI1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0039849", "map_id": "FBgn0039849", "name": "MRI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458279", "map_id": "none", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353106", "map_id": "CHEBI:17509", "name": "MTAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458276", "map_id": "none", "name": "MTAP trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V813", "map_id": "Q9V813", "name": "Mtap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034215", "map_id": "FBgn0034215", "name": "Mtap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458259", "map_id": "none", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29460", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1237122", "map_id": "CHEBI:16723", "name": "4MTOBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458256", "map_id": "none", "name": "ARD:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6AWN0", "map_id": "Q6AWN0", "name": "Adi1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052068", "map_id": "FBgn0052068", "name": "Adi1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455900", "map_id": "none", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975910", "map_id": "CHEBI:59520", "name": "NGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_981618", "map_id": "none", "name": "Glycoprotein with galactose", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10455845", "map_id": "none", "name": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_981616", "map_id": "none", "name": "Glycoprotein with GlcNAc in position 4", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10455842", "map_id": "none", "name": "MGAT4s", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VUH5", "map_id": "Q9VUH5", "name": "Magt4b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036447", "map_id": "FBgn0036447", "name": "Magt4b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUH4", "map_id": "Q9VUH4", "name": "Mgat4a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036446", "map_id": "FBgn0036446", "name": "Mgat4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455826", "map_id": "none", "name": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975925", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_981615", "map_id": "none", "name": "Glycoprotein-Neu5Ac", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10440190", "map_id": "none", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_171076", "map_id": "CHEBI:17002", "name": "CHEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_171149", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_174602", "map_id": "CHEBI:15904", "name": "LCFAs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10440187", "map_id": "none", "name": "dimerized CEL:bile salt complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17687", "map_id": "CHEBI:17687", "name": "CHEBI:17687", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28865", "map_id": "CHEBI:28865", "name": "CHEBI:28865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16755", "map_id": "CHEBI:16755", "name": "CHEBI:16755", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36274", "map_id": "CHEBI:36274", "name": "CHEBI:36274", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_193473", "map_id": "CHEBI:16359", "name": "CCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:9407", "map_id": "CHEBI:9407", "name": "CHEBI:9407", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440195", "map_id": "none", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10440193", "map_id": "none", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6814795", "map_id": "CHEBI:17408", "name": "MAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_192438", "map_id": "CHEBI:17754", "name": "glycerol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10495454", "map_id": "none", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10495451", "map_id": "none", "name": "digestive LIPs", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10439518", "map_id": "none", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189075", "map_id": "none", "name": "starch (amylose)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_964746", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_191103", "map_id": "CHEBI:27931", "name": "maltotriose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_188986", "map_id": "CHEBI:17306", "name": "Mal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10439515", "map_id": "none", "name": "alpha-amylase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O18408", "map_id": "O18408", "name": "Amyrel", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020506", "map_id": "FBgn0020506", "name": "Amyrel", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P81641", "map_id": "P81641", "name": "Amy-d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000078", "map_id": "FBgn0000078", "name": "Amy-d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P08144", "map_id": "P08144", "name": "Amy-p", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000079", "map_id": "FBgn0000079", "name": "Amy-p", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479867", "map_id": "none", "name": "CHIA hydrolyses chitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6786438", "map_id": "none", "name": "chitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_6786426", "map_id": "CHEBI:86362", "name": "GlcNAc-beta1,4-GlcNAc-beta1,4-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_6786428", "map_id": "CHEBI:86361", "name": "GlcNAc-beta1,4-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10479864", "map_id": "Q9W092", "name": "Cht2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "FBgn0022702", "map_id": "FBgn0022702", "name": "Cht2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439525", "map_id": "none", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_188973", "map_id": "CHEBI:17716", "name": "Lac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_70115", "map_id": "CHEBI:17925", "name": "Glc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_188995", "map_id": "CHEBI:17118", "name": "Gal", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10439522", "map_id": "none", "name": "LCT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10479907", "map_id": "none", "name": "CHIT1 hydrolyses CHIT to 3xADGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6786654", "map_id": "CHEBI:84373", "name": "CHIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_6786660", "map_id": "CHEBI:47977", "name": "ADGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10479904", "map_id": "none", "name": "Homologues of CHIT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q8T0R7", "map_id": "Q8T0R7", "name": "Idgf5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0064237", "map_id": "FBgn0064237", "name": "Idgf5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W303", "map_id": "Q9W303", "name": "Idgf4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026415", "map_id": "FBgn0026415", "name": "Idgf4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MM24", "map_id": "Q8MM24", "name": "Idgf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020416", "map_id": "FBgn0020416", "name": "Idgf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZV2", "map_id": "Q9VZV2", "name": "Cht7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035398", "map_id": "FBgn0035398", "name": "Cht7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MLZ7", "map_id": "Q8MLZ7", "name": "Idgf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020414", "map_id": "FBgn0020414", "name": "Idgf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3D4", "map_id": "Q9V3D4", "name": "Idgf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020415", "map_id": "FBgn0020415", "name": "Idgf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q23997", "map_id": "Q23997", "name": "Idgf6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013763", "map_id": "FBgn0013763", "name": "Idgf6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439922", "map_id": "none", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_189071", "map_id": "none", "name": "starch (amylopectin)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_189108", "map_id": "CHEBI:28912", "name": "limit dextrins", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10491791", "map_id": "none", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8878780", "map_id": "CHEBI:7794", "name": "phosphate monoester", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10491788", "map_id": "none", "name": "ALPI:2Ca2+:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VRM9", "map_id": "Q9VRM9", "name": "Alp9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035620", "map_id": "FBgn0035620", "name": "Alp9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXS8", "map_id": "Q9VXS8", "name": "Alp11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030661", "map_id": "FBgn0030661", "name": "Alp11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W273", "map_id": "Q9W273", "name": "Alp8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034712", "map_id": "FBgn0034712", "name": "Alp8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W274", "map_id": "Q9W274", "name": "Alp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283480", "map_id": "FBgn0283480", "name": "Alp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W275", "map_id": "Q9W275", "name": "Alp7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034710", "map_id": "FBgn0034710", "name": "Alp7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PD70", "map_id": "M9PD70", "name": "Alp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283479", "map_id": "FBgn0283479", "name": "Alp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24238", "map_id": "Q24238", "name": "Alp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016123", "map_id": "FBgn0016123", "name": "Alp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K3X8", "map_id": "Q7K3X8", "name": "Alp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033423", "map_id": "FBgn0033423", "name": "Alp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDG4", "map_id": "Q9VDG4", "name": "Alp5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038845", "map_id": "FBgn0038845", "name": "Alp5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH28", "map_id": "Q9VH28", "name": "Alp13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037786", "map_id": "FBgn0037786", "name": "Alp13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHD0", "map_id": "Q9VHD0", "name": "phu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0043791", "map_id": "FBgn0043791", "name": "phu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIW9", "map_id": "Q9VIW9", "name": "Alp12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032779", "map_id": "FBgn0032779", "name": "Alp12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRM8", "map_id": "Q9VRM8", "name": "Alp10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035619", "map_id": "FBgn0035619", "name": "Alp10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477790", "map_id": "none", "name": "TNFAIP3 (A20) ubiquitinates RIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454480", "map_id": "none", "name": "K48polyUb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10477782", "map_id": "none", "name": "TNFAIP3:RIPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P83104", "map_id": "P83104", "name": "Takl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0046689", "map_id": "FBgn0046689", "name": "Takl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH90", "map_id": "Q9VH90", "name": "trbd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037734", "map_id": "FBgn0037734", "name": "trbd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477787", "map_id": "none", "name": "TNFAIP3:K48polyUb-RIPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10477822", "map_id": "none", "name": "OTUD7B,TNFAIP3 deubiquitinate TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477817", "map_id": "none", "name": "OTUD7B,TNFAIP3,ZRANB1:K48polyUb-TRAF6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W3I9", "map_id": "Q9W3I9", "name": "Traf6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265464", "map_id": "FBgn0265464", "name": "Traf6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477819", "map_id": "none", "name": "OTUD7B,TNFAIP3,ZRANB1:TRAF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479341", "map_id": "none", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479337", "map_id": "Q9VRJ9", "name": "YOD1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035593", "map_id": "FBgn0035593", "name": "YOD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471517", "map_id": "Q7KN62", "name": "TER94", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0286784", "map_id": "FBgn0286784", "name": "TER94", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479339", "map_id": "none", "name": "YOD1:VCP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KN62", "map_id": "Q7KN62", "name": "TER94", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRJ9", "map_id": "Q9VRJ9", "name": "YOD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477802", "map_id": "none", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477794", "map_id": "none", "name": "OTUB1,(OTUB2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VL00", "map_id": "Q9VL00", "name": "OTUB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032214", "map_id": "FBgn0032214", "name": "OTUB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477798", "map_id": "none", "name": "RNF128,TRAF3,TRAF6,RHOA,TP53", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q06003", "map_id": "Q06003", "name": "gol", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004919", "map_id": "FBgn0004919", "name": "gol", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IMZ4", "map_id": "Q8IMZ4", "name": "p53", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039044", "map_id": "FBgn0039044", "name": "p53", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477800", "map_id": "none", "name": "OTUB1,(OTUB2):RNF128,TRAF3,TRAF6,RHOA,TP53", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479481", "map_id": "none", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479475", "map_id": "none", "name": "OTUB1,(OTUB2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10479477", "map_id": "none", "name": "UBE2D1,ESR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10479479", "map_id": "none", "name": "OTUB1,(OTUB2):UBE2D1,ESR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10490409", "map_id": "none", "name": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10490406", "map_id": "none", "name": "OTUD7B,TNFAIP3,ZRANB1:K63polyUb-TRAF6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437507", "map_id": "none", "name": "K63polyUb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10477810", "map_id": "none", "name": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477807", "map_id": "none", "name": "TNFAIP3:K63polyUb-RIPK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479330", "map_id": "none", "name": "ZRANB1 binds APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477812", "map_id": "Q9VH90", "name": "trbd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440558", "map_id": "none", "name": "Homologues of K63polyUb-APC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10479328", "map_id": "none", "name": "ZRANB1:K63polyUb-APC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209107", "map_id": "none", "name": "Further phosphorylation of APC by DCO", "reversible": "false", "notes": "Three Serine residues in APC (APC/APC2) are further phosphorylated by DCO. Ser1504, Ser1507 (priming), and Ser1510 in Human APC are further phosphorylated by CKIepsilon.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206811", "map_id": "none", "name": "Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206735", "map_id": "none", "name": "Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209143", "map_id": "none", "name": "Phosphorylation of AXN and APC by DCO", "reversible": "false", "notes": "Axin (AXN) and APC (APC/APC2) in the 'destruction complex' are primed for phosphorylation by the CKIepsilon orthologue DCO. Ser1505 in Human APC and Ser531 in Human Axin (equivalent to Ser621 in Mouse and Ser529 in Fly) are phosphorylated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_209082", "map_id": "none", "name": "Further phosphorylation of APC by SGG", "reversible": "false", "notes": "A Serine in APC (APC/APC2) is further phosphorylated by Shaggy (SGG). Ser1503 in Human APC is phosphorylated by GSK3beta.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206602", "map_id": "none", "name": "Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209049", "map_id": "none", "name": "Phosphorylation of AXN and APC by SGG", "reversible": "false", "notes": "Additional phosphorylation of the scaffolding molecules, Axin (AXN) and APC (APC/APC2), is carried out by the GSK3beta kinase orthologue Shaggy (SGG) with Ser1501 (also a priming phosphorylation) in Human APC and Ser614 and Thr609 in Mouse Axin (equivalent to Ser522 and Thr517 respectively in Fly and Ser524 and Thr519 in Human).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_209109", "map_id": "none", "name": "Further phosphorylation of ARM by SGG", "reversible": "false", "notes": "Phosphorylation of bound Armadillo (ARM) at Ser44, Ser48, and Thr52 by Shaggy (SGG) occurs.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206805", "map_id": "none", "name": "Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_207028", "map_id": "none", "name": "Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209134", "map_id": "none", "name": "Phosphorylation of ARM by CKIalpha", "reversible": "false", "notes": "Armadillo (ARM) is primed for phosphorylation by CKIalpha at Ser56.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206666", "map_id": "none", "name": "ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209097", "map_id": "none", "name": "ARM binds to APC and AXN in the 'destruction complex'", "reversible": "false", "notes": "Phosphorylated APC (APC/APC2) and Axin (AXN) are able to bind cytoplasmic Armadillo (ARM) more strongly. This now brings ARM into the 'destruction complex' and within reach of the complexed kinases.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_205774", "map_id": "P18824", "name": "ARM", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209133", "map_id": "none", "name": "Formation of the 'destruction complex'", "reversible": "false", "notes": "The 'destruction complex' is formed from the large scaffolding proteins Axin (AXN) and APC (APC/APC2). This enables regulating molecules such as the kinases, CKIalpha, DCO, and Shaggy (SGG) and the phosphatase, PP2A to be held together in close proximity where they can regulate the phosphorylation of the scaffolding molecules and cytoplasmic Armadillo (ARM). The protein serine/threonine phosphatase PP2A is made up of the regulatory subunit A, PP2A-29B; the regulatory subunit B, Twins (TWS); and the catalytic subunit C, Microtubule star (MTS).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_205716", "map_id": "P18431", "name": "SGG", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206581", "map_id": "none", "name": "APC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206017", "map_id": "Q9V407", "name": "AXN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206210", "map_id": "P54367", "name": "CKIalpha", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10436639", "map_id": "none", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432514", "map_id": "none", "name": "Homologues of AGPAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q7KTI0", "map_id": "Q7KTI0", "name": "Agpat2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026718", "map_id": "FBgn0026718", "name": "Agpat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYJ4", "map_id": "Q9VYJ4", "name": "Agpat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030421", "map_id": "FBgn0030421", "name": "Agpat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436628", "map_id": "none", "name": "ChREBP:MLX", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VID4", "map_id": "Q9VID4", "name": "Mondo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032940", "map_id": "FBgn0032940", "name": "Mondo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB47", "map_id": "Q9VB47", "name": "bigmax", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039509", "map_id": "FBgn0039509", "name": "bigmax", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436637", "map_id": "none", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10436635", "map_id": "A1Z784", "name": "ACC", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0033246", "map_id": "FBgn0033246", "name": "phospho-ACC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436630", "map_id": "none", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432485", "map_id": "B7Z001", "name": "phospho-FASN1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0283427", "map_id": "FBgn0283427", "name": "phospho-FASN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433767", "map_id": "none", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433763", "map_id": "Q24324", "name": "phospho-Dsor1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433796", "map_id": "none", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10428216", "map_id": "none", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29448", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76213", "map_id": "CHEBI:30744", "name": "OA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428192", "map_id": "none", "name": "PXLP-K259-GOT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1ZAA5", "map_id": "A1ZAA5", "name": "Got1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001124", "map_id": "FBgn0001124", "name": "Got1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444310", "map_id": "none", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113553", "map_id": "CHEBI:29991", "name": "L-Asp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113552", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10444305", "map_id": "Q9VA73", "name": "aralar1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0028646", "map_id": "FBgn0028646", "name": "aralar1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479958", "map_id": "none", "name": "PXLP-K333-GADL1 decarboxylates acidic AAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787759", "map_id": "none", "name": "GADL1 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1614519", "map_id": "CHEBI:16345", "name": "3-Sulfinoalanine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:17285", "map_id": "CHEBI:17285", "name": "CHEBI:17285", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6787762", "map_id": "none", "name": "GADL1 products", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_73590", "map_id": "CHEBI:16958", "name": "b-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1655445", "map_id": "CHEBI:16668", "name": "HTAU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:15891", "map_id": "CHEBI:15891", "name": "CHEBI:15891", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479955", "map_id": "none", "name": "PXLP-K333-GADL1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VPH6", "map_id": "Q9VPH6", "name": "Dmel\\CG5618", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036975", "map_id": "FBgn0036975", "name": "Dmel\\CG5618", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24062", "map_id": "Q24062", "name": "b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000153", "map_id": "FBgn0000153", "name": "b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10481284", "map_id": "none", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29642", "map_id": "CHEBI:58048", "name": "L-Asn", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29382", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10481281", "map_id": "Q9W4N6", "name": "CG-6428", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0029689", "map_id": "FBgn0029689", "name": "CG-6428", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428227", "map_id": "none", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113594", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113587", "map_id": "CHEBI:30744", "name": "OAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428224", "map_id": "none", "name": "GOT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q8IPY3", "map_id": "Q8IPY3", "name": "Got2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001125", "map_id": "FBgn0001125", "name": "Got2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428195", "map_id": "none", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10460687", "map_id": "none", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614518", "map_id": "CHEBI:17482", "name": "L-Cystathionine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111707", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_936714", "map_id": "CHEBI:30831", "name": "2OBUTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10460681", "map_id": "none", "name": "PXLP-K212-CTH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7JXZ2", "map_id": "Q7JXZ2", "name": "Eip55E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000566", "map_id": "FBgn0000566", "name": "Eip55E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460661", "map_id": "none", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174369", "map_id": "CHEBI:17230", "name": "HCYS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10460658", "map_id": "none", "name": "PXLP-CBS tetramers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VRD9", "map_id": "Q9VRD9", "name": "Cbs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031148", "map_id": "FBgn0031148", "name": "Cbs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498480", "map_id": "none", "name": "JAK3 binds JAK3 inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678772", "map_id": "none", "name": "JAK3 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453150", "map_id": "Q24592", "name": "hop", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10498478", "map_id": "none", "name": "JAK3:JAK3 inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10480006", "map_id": "none", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10480000", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10480004", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479859", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479790", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y614-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10479857", "map_id": "none", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10480307", "map_id": "none", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10480305", "map_id": "Q9VAY2", "name": "Gp93", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "FBgn0039562", "map_id": "FBgn0039562", "name": "phospho-Gp93", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457732", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10480002", "map_id": "none", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479786", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10479792", "map_id": "none", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457718", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498451", "map_id": "none", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10498447", "map_id": "Q9VI74", "name": "SHQ1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0037482", "map_id": "FBgn0037482", "name": "SHQ1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436122", "map_id": "O44081", "name": "Nop60B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0259937", "map_id": "FBgn0259937", "name": "Nop60B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498449", "map_id": "none", "name": "DKC1:SHQ1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O44081", "map_id": "O44081", "name": "Nop60B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VI74", "map_id": "Q9VI74", "name": "SHQ1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_169827", "map_id": "none", "name": "DPDK1 phosphorylates and activates DS6K", "reversible": "false", "notes": "DPDK1 is thought to directly phosphorylate a Threonine residue in the activation loop of the p70 DS6K catalytic domain.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110503", "map_id": "P91656", "name": "S6K", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110505", "map_id": "P91656", "name": "Phosphorylated DS6K", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110528", "map_id": "Q9W0V1", "name": "PK61C", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_110498", "map_id": "none", "name": "DTOR is positively regulated by DRheb-GTP", "reversible": "false", "notes": "Insulin signaling stimulates cell growth through the conserved protein kinase DTOR (target of rapamycin). DTOR is positively regulated by DRheb-GTP by a mechanism which has yet to be deciphered although a serine residue is thought to be phosphorylated on DTOR.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110495", "map_id": "Q8T9I6", "name": "TOR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110497", "map_id": "Q8T9I6", "name": "Activated DTOR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_110485", "map_id": "none", "name": "DTSC1 AND DTSC2 form a complex", "reversible": "false", "notes": "Tuberous sclerosis is a human disease caused by mutated TSC1 or TSC2 tumor repressor genes. The Drosophila equivalents form a complex and are negative regulators of TOR signaling.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110482", "map_id": "Q9U9B0", "name": "GIG", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110480", "map_id": "Q9U9A9", "name": "TSC1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110484", "map_id": "none", "name": "DTSC1:DTSC2 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9U9A9", "map_id": "Q9U9A9", "name": "TSC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "TSC1", "map_id": "TSC1", "name": "TSC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U9B0", "map_id": "Q9U9B0", "name": "Phospho-DTSC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho-DTSC2", "map_id": "Phospho-DTSC2", "name": "Phospho-DTSC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_165127", "map_id": "none", "name": "GEF binds to the inactive DRheb", "reversible": "false", "notes": "The interaction of DRheb with its guanine nucleotide exchange factor (GEF) has not been studied experimentally, but is inferred here by analogy to the very well-studied interaction of Ran GTPase with RCC1 (Azuma et al. 1999; Renault et al. 2001). GEF binds reversibly to the DRheb-GDP complex, forming a GEF:GTPase:GDP complex. Complex formation induces a change in the shape of the GTPase, substantially reducing its affinity for bound guanine nucleotide.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_165124", "map_id": "Q95V18", "name": "GEF", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110416", "map_id": "none", "name": "DRheb-GDP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VND8", "map_id": "Q9VND8", "name": "Rheb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rheb", "map_id": "Rheb", "name": "Rheb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_165123", "map_id": "none", "name": "GEF:DRheb-GDP complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q95V18", "map_id": "Q95V18", "name": "GEF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "GEF", "map_id": "GEF", "name": "GEF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_169828", "map_id": "none", "name": "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex", "reversible": "false", "notes": "DTSC2 is inactivated by DAkt1-dependent phosphorylation of residues threonine (1518) and serine (924) which is thought to destabilize DTSC2 and disrupt it's interaction with DTSC1.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_169826", "map_id": "Q9U9B0", "name": "Phospho-DTSC2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110466", "map_id": "Q8INB9", "name": "Activated DAkt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_110518", "map_id": "none", "name": "Activated DTOR also phosphorylates D4EBP", "reversible": "false", "notes": "DeIF4E is an initiation factor for eukaryotic translation. D4EBP forms a complex with DeIF4E, inactivating the latter. Activated DTOR phosphorylates D4EBP on a threonine residue, causing it to dissociate from DeIF4E.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110512", "map_id": "none", "name": "DeIF4E:D4EBP complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XZ56", "map_id": "Q9XZ56", "name": "Thor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Thor", "map_id": "Thor", "name": "Thor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_110511", "map_id": "P48598", "name": "EIF-4E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110517", "map_id": "Q9XZ56", "name": "Phosphorylated D4EBP", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_165131", "map_id": "none", "name": "GEF dissociates from DRheb-GTP", "reversible": "false", "notes": "The interaction of DRheb with its guanine nucleotide exchange factor (GEF) has not been studied experimentally, but is inferred here by analogy to the very well-studied interaction of Ran GTPase with RCC1 (Azuma et al. 1999; Renault et al. 2001). The GEF:DRheb-GTP complex dissociates reversibly to GEF + DRheb-GTP. The affinity of GTPase for bound nucleotide returns to its high value, so the nucleotide now stays strongly bound.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_165125", "map_id": "none", "name": "GEF:DRheb-GTP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_110415", "map_id": "none", "name": "DRheb-GTP complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_110491", "map_id": "none", "name": "DRheb is inhibited by the TSC1/2 complex", "reversible": "false", "notes": "The DTSC1/2 complex antagonizes the amino-acid-TOR signaling pathway. DTSC1/2 complex has a GTPase-activating protein domain (GAP). DRheb (a small GTPase called Ras homologue enriched in brain) is a target for DTSC2 GAP activity. As DRheb is a downstream effector from DTSC1/2, its inhibition by DTSC1/2 results in growth inhibition.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_165129", "map_id": "none", "name": "GDP is exchanged for GTP on DRheb", "reversible": "false", "notes": "The GEF:DRheb-GDP complex freely exchanges its bound nucleotide for free nucleotide from the cytosol. Normally, the concentration of cytosolic GTP is about ten times greater than the concentration of GDP, so under physiological conditions, this exchange event favors formation of DRheb-GTP.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_110506", "map_id": "none", "name": "Activated DTOR phosphorylates DS6K", "reversible": "false", "notes": "DTOR phosphorylates a threonine residue on DS6K, which is an important effector of cell growth.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_110437", "map_id": "none", "name": "DILP binds to Drosophila insulin receptor (DINR)", "reversible": "false", "notes": "Drosophila contains seven insulin-like genes which encode for DILP (Drosophila Insulin-like peptide)1-7. These DILPs can bind to the Drosophila Insulin receptor (DINR) to initiate intracellular signaling.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_110422", "map_id": "none", "name": "insulin receptor (DINR)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_164721", "map_id": "none", "name": "DILP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VT51", "map_id": "Q9VT51", "name": "ILP2 alpha chain", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ILP2 alpha chain", "map_id": "ILP2 alpha chain", "name": "ILP2 alpha chain", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VT53", "map_id": "Q9VT53", "name": "ILP4 alpha chain", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ILP4 alpha chain", "map_id": "ILP4 alpha chain", "name": "ILP4 alpha chain", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VT52", "map_id": "Q9VT52", "name": "ILP3 alpha chain", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ILP3 alpha chain", "map_id": "ILP3 alpha chain", "name": "ILP3 alpha chain", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KUD5", "map_id": "Q7KUD5", "name": "ILP5 alpha chain", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ILP5 alpha chain", "map_id": "ILP5 alpha chain", "name": "ILP5 alpha chain", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4Q9", "map_id": "Q9W4Q9", "name": "ILP7 alpha chain", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ILP7 alpha chain", "map_id": "ILP7 alpha chain", "name": "ILP7 alpha chain", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VT50", "map_id": "Q9VT50", "name": "ILP1 alpha chain", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ILP1 alpha chain", "map_id": "ILP1 alpha chain", "name": "ILP1 alpha chain", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4Z4", "map_id": "Q9W4Z4", "name": "ILP6 alpha chain", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ILP6 alpha chain", "map_id": "ILP6 alpha chain", "name": "ILP6 alpha chain", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_110427", "map_id": "none", "name": "DILP:DINR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_110453", "map_id": "none", "name": "Phosphorylation of PIP2 to PIP3 by Dp110", "reversible": "false", "notes": "PI3Ks are implicated in cell growth, number and size. Dp110, the Drosophila PI3K, phosphorylates PIP2 -> PIP3 (both intracellular messengers) to continue the signaling mechanism. Overexpression of Dp110 results in enlarged cell size and number suggesting a role for Dp110 in growth and size control.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_38117", "map_id": "CHEBI:16618", "name": "PIP3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_110435", "map_id": "none", "name": "p60:Dp110:Phospho-Chico:Activated DINR complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O18683", "map_id": "O18683", "name": "PI3K21B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PI3K21B", "map_id": "PI3K21B", "name": "PI3K21B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_110468", "map_id": "none", "name": "Activation of DAkt1 by DPDK1", "reversible": "false", "notes": "DPDK1 (a phosphoinositide-dependant protein kinase) controls cellular and organism growth through two effector pathways by activating DAkt and DS6K (S6 kinase). Phosphorylation of the residues Thr308 and Ser473 by DPDK1 (and another downstream kinase?) relieves intermolecular inhibition, allowing the activated DAkt to dissociate from PIP3 and modify its target, DFOXO.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110452", "map_id": "none", "name": "DAkt1:PIP3 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_110440", "map_id": "none", "name": "Autophosphorylation of DINR", "reversible": "false", "notes": "Binding of a DILP to DINR induces a conformational change leading to autophosphorylation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110426", "map_id": "none", "name": "Activated DINR:DILP complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_164696", "map_id": "none", "name": "Chico is phosphorylated", "reversible": "false", "notes": "The beta subunit of the DINR complex binds and phosphorylates Chico. Chico has 3 phosphotyrosine binding domains on residues 411, 911 and 948 where it can be phosphorylated. The tyrosine kinase function of DINR phosphorylates Chico on these domains. Phosphorylated Chico binds to SH2 domain-containing proteins such as PI3K (Phosphoinositide 3-Kinase).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110430", "map_id": "none", "name": "Chico:Activated DINR:DILP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_164707", "map_id": "none", "name": "Phospho-Chico:Activated DINR complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_110459", "map_id": "none", "name": "PIP3 dephosphorylated to PIP2 by DPTEN", "reversible": "false", "notes": "DPTEN (a phosphoinositide phosphatase) catalyses the reversal of PIP3 to PIP2. This mechanism, together with Dp110 activity, regulates the levels of PIP3 which is the second messenger for controlling organism size.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110456", "map_id": "Q7KMQ6", "name": "DPTEN", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_110475", "map_id": "none", "name": "DAkt1-mediated phosphorylation inactivates DFOXO", "reversible": "false", "notes": "DFOXO belongs to the FOXO subfamily of forkhead transcription factors. The FOXO factors regulate genes involved in cell cycle control, cell death and stress responses. Phosphorylation of DFOXO by DAkt1 on three residues (Thr44, Ser190 and Ser259) leads to its cytoplasmic retention and inactivation, inhibiting expression of DFOXO-regulated genes. These include D4EBP, DInR and Chico.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110472", "map_id": "Q95V55", "name": "FOXO", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_110474", "map_id": "Q95V55", "name": "Phosphorylated DFOXO", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_110442", "map_id": "none", "name": "Activated DINR binds Chico", "reversible": "false", "notes": "The Drosophila homologue to mammalian IRS1-4 (Insulin Receptor Substrate), Chico, binds to the beta subunit of DINR. Chico is an adaptor protein that interacts with the activated drosophila insulin-like receptor (DINR), allowing signaling molecules to attach and signal to downstream effectors.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110429", "map_id": "Q9XTN2", "name": "CHICO", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_110463", "map_id": "none", "name": "Increased PIP3 levels recruit DAkt1 to the membrane", "reversible": "false", "notes": "DAkt (a protein kinase B) is recruited to the plasma membrane due to the interaction between its PH (pleckstrin homology) domain and PIP3. In Drosophila, DAkt appears to be the only target activated by increased PIP3 levels.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110462", "map_id": "Q8INB9", "name": "AKT1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_110446", "map_id": "none", "name": "Phospho-Chico: Activated DINR binds p60:Dp110", "reversible": "false", "notes": "The Phospho-Chico: Activated DINR in the plasma membrane binds to cytosolic p60:p110. The p60 subunit of the latter complex mediates this interaction; the p110 subunit is the Drosophila PI3K. This complex is an active protein kinase whose direct and indirect targets include PIP2, annotated here.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110434", "map_id": "none", "name": "p60:Dp110 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461117", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806195", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "species_1806198", "map_id": "CHEBI:17283", "name": "PI3P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10461070", "map_id": "none", "name": "PIK3C2A/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K3H0", "map_id": "Q7K3H0", "name": "Pi3K68D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015278", "map_id": "FBgn0015278", "name": "Pi3K68D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461137", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_1806289", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1806212", "map_id": "CHEBI:16500", "name": "PI5P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10461006", "map_id": "none", "name": "MTM1,MTMR2,MTMR4,MTMR7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8MLR7", "map_id": "Q8MLR7", "name": "Mtmr6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028497", "map_id": "FBgn0028497", "name": "Mtmr6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YU03", "map_id": "Q7YU03", "name": "Dmel\\CG3632", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030735", "map_id": "FBgn0030735", "name": "Dmel\\CG3632", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMI9", "map_id": "Q9VMI9", "name": "mtm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025742", "map_id": "FBgn0025742", "name": "mtm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461009", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "reaction_10445980", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10445976", "map_id": "Q8SX87", "name": "Atf6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0033010", "map_id": "FBgn0033010", "name": "Atf6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445962", "map_id": "Q8SX87", "name": "Atf6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10445916", "map_id": "none", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445912", "map_id": "Q8SX87", "name": "Atf6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10445914", "map_id": "Q8SX87", "name": "Atf6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10447719", "map_id": "none", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10445964", "map_id": "Q8SX87", "name": "Atf6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10447711", "map_id": "Q8SX87", "name": "Atf6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10447716", "map_id": "Q7JZ56", "name": "S2P", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0033656", "map_id": "FBgn0033656", "name": "S2P", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445974", "map_id": "none", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10445966", "map_id": "Q8SX87", "name": "Atf6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10445971", "map_id": "Q9VP10", "name": "S1P", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0037105", "map_id": "FBgn0037105", "name": "S1P", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_209303", "map_id": "none", "name": "LGS transports from the nucleus to the cytosol", "reversible": "false", "notes": "The free Legless (LGS) protein exports from the nucleus to the cytoplasm by an unknown mechanism potentially with additional interaction partners, where it can now target Armadillo (ARM), which is now not being rapidly removed from the cytoplasm by the 'destruction complex'.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_205826", "map_id": "Q961D9", "name": "LGS", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_205724", "map_id": "Q961D9", "name": "LGS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209332", "map_id": "none", "name": "LGS dissociates from the PYGO complex", "reversible": "false", "notes": "The inactivation and destabilisation of the 'destruction complex' means elevated levels of cytoplasmic Armadillo (ARM). In the nucleus, the protein Legless (LGS) dissociates from its nuclear anchor, Pygopus (PYGO).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_206853", "map_id": "none", "name": "LGS:PYGO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_205990", "map_id": "Q9V9W8", "name": "PYGO", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_209371", "map_id": "none", "name": "LGS binds to ARM", "reversible": "false", "notes": "The targeted free cytoplasmic Armadillo (ARM) is complexed to Legless (LGS).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206796", "map_id": "none", "name": "LGS:ARM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209177", "map_id": "none", "name": "LGS:ARM complex transports from the cytosol to the nucleus", "reversible": "false", "notes": "The Legless:Armadillo (LGS:ARM) complex is imported to the nucleus by an unknown mechanism which may include additional interaction partners.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_206839", "map_id": "none", "name": "LGS:ARM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10461167", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1806234", "map_id": "CHEBI:17526", "name": "PI4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_426639", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10461164", "map_id": "Q9W0I6", "name": "Sac1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0283500", "map_id": "FBgn0283500", "name": "Sac1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461022", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10461019", "map_id": "none", "name": "PI4KA/2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "M9PDM4", "map_id": "M9PDM4", "name": "Pi4KIIIalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267350", "map_id": "FBgn0267350", "name": "Pi4KIIIalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VND3", "map_id": "Q9VND3", "name": "Pi4KIIalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037339", "map_id": "FBgn0037339", "name": "Pi4KIIalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486803", "map_id": "none", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486799", "map_id": "Q9VGH9", "name": "Sbf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0025802", "map_id": "FBgn0025802", "name": "Sbf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460994", "map_id": "Q9VMI9", "name": "mtm", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486801", "map_id": "none", "name": "MTMR2:SBF1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VGH9", "map_id": "Q9VGH9", "name": "Sbf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486806", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5676030", "map_id": "CHEBI:26034", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10486809", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6809774", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_422529", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10486896", "map_id": "none", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_172574", "compartment_display": "late endosome membrane" }, { "id": "species_10486892", "map_id": "Q9VT69", "name": "Dmel\\CG6707", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_172574", "compartment_display": "late endosome membrane", "complex": "false" }, { "id": "FBgn0036058", "map_id": "FBgn0036058", "name": "Dmel\\CG6707", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486894", "map_id": "Q9VT69", "name": "Dmel\\CG6707", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10486899", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6810412", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_6810408", "map_id": "CHEBI:16500", "name": "PI5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10487163", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10487160", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8SXX1", "map_id": "Q8SXX1", "name": "PIP4K", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039924", "map_id": "FBgn0039924", "name": "PIP4K", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461051", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1524146", "map_id": "CHEBI:16749", "name": "PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_1806217", "map_id": "CHEBI:17526", "name": "PI4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10461048", "map_id": "none", "name": "ARF1/3:GTP:PI4KB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P61209", "map_id": "P61209", "name": "Arf79F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010348", "map_id": "FBgn0010348", "name": "Arf79F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4D6K881", "map_id": "A0A4D6K881", "name": "fwd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004373", "map_id": "FBgn0004373", "name": "fwd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461210", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10461207", "map_id": "none", "name": "PI4KA/2A/2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461162", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806159", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10461159", "map_id": "Q9W0I6", "name": "Sac1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10461094", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10461062", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806230", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10461059", "map_id": "none", "name": "PIK3C2A/G", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461188", "map_id": "none", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10461186", "map_id": "A0A4D6K881", "name": "fwd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10461046", "map_id": "none", "name": "ARF1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10461027", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1806165", "map_id": "CHEBI:18348", "name": "PI(4,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10461024", "map_id": "O46094", "name": "Ocrl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10461170", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10490964", "map_id": "none", "name": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane" }, { "id": "species_8874484", "map_id": "none", "name": "PI(4,5)P2, PI(3,4,5)P3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_8874460", "map_id": "none", "name": "PI(4,5)P2, PI(3,4,5)P3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10490961", "map_id": "none", "name": "TNFAIP8 proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KVH9", "map_id": "Q7KVH9", "name": "TNFAIP8L3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034894", "map_id": "FBgn0034894", "name": "TNFAIP8L3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461198", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806238", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_1806200", "map_id": "CHEBI:17283", "name": "PI3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10461193", "map_id": "Q9VY47", "name": "CG1846", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0259166", "map_id": "FBgn0259166", "name": "CG1846", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486787", "map_id": "none", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486783", "map_id": "Q9VY15", "name": "Dmel\\CG14411", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030582", "map_id": "FBgn0030582", "name": "Dmel\\CG14411", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460992", "map_id": "Q9VMI9", "name": "mtm", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486785", "map_id": "none", "name": "MTM1:MTMR12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VY15", "map_id": "Q9VY15", "name": "Dmel\\CG14411", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461145", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806205", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_1806259", "map_id": "CHEBI:16500", "name": "PI5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10461142", "map_id": "none", "name": "MTM1,MTMR2,MTMR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461176", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806199", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "reaction_10486791", "map_id": "none", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486789", "map_id": "none", "name": "MTMR2:MTMR12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461096", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_1806180", "map_id": "CHEBI:17526", "name": "PI4P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10460982", "map_id": "Q9VND3", "name": "Pi4KIIalpha", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488313", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8849959", "map_id": "none", "name": "PI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_202247", "map_id": "CHEBI:16152", "name": "PI(3,4)P2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_8849958", "map_id": "none", "name": "PI5P, PI3P, PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10488310", "map_id": "Q0KI33", "name": "Dmel\\CG7956", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "FBgn0038890", "map_id": "FBgn0038890", "name": "Dmel\\CG7956", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486794", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10461073", "map_id": "none", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "reaction_10461216", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10461055", "map_id": "none", "name": "PIK3C2A:Ca2+/Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10487317", "map_id": "none", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6814253", "map_id": "CHEBI:58168", "name": "LysoPtdCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1498750", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1524021", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10487314", "map_id": "Q9U969", "name": "sws", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0003656", "map_id": "FBgn0003656", "name": "sws", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487177", "map_id": "none", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_6813734", "map_id": "CHEBI:58444", "name": "GroPIns", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_426910", "map_id": "CHEBI:17268", "name": "Ins", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_76114", "map_id": "CHEBI:15978", "name": "G3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10487174", "map_id": "Q9VEU9", "name": "Dmel\\CG14883", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0038432", "map_id": "FBgn0038432", "name": "Dmel\\CG14883", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441150", "map_id": "none", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10461181", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806276", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10461178", "map_id": "none", "name": "PIP4K2/5K1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461213", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1806224", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1806240", "map_id": "CHEBI:16500", "name": "PI5P", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10461112", "map_id": "none", "name": "MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1ZAS8", "map_id": "A1ZAS8", "name": "EDTP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027506", "map_id": "FBgn0027506", "name": "EDTP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461115", "map_id": "none", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426658", "map_id": "CHEBI:16749", "name": "PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10460987", "map_id": "none", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10460951", "map_id": "none", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10460948", "map_id": "none", "name": "PIP5K1A-C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461205", "map_id": "none", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461202", "map_id": "none", "name": "SYNJ/INPP5(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K161", "map_id": "Q7K161", "name": "IPP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034179", "map_id": "FBgn0034179", "name": "IPP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461173", "map_id": "none", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10461140", "map_id": "none", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10461012", "map_id": "none", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10486766", "map_id": "none", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486762", "map_id": "Q8SZY7", "name": "Dmel\\CG5026", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035945", "map_id": "FBgn0035945", "name": "Dmel\\CG5026", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486757", "map_id": "Q8MLR7", "name": "Mtmr6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486764", "map_id": "none", "name": "MTMR8:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8SZY7", "map_id": "Q8SZY7", "name": "Dmel\\CG5026", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460977", "map_id": "none", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10460974", "map_id": "none", "name": "PIP4K2 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461200", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10461039", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461036", "map_id": "none", "name": "SYNJs,OCRL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461134", "map_id": "none", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461131", "map_id": "none", "name": "PIK3C(1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10486770", "map_id": "none", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10461105", "map_id": "Q8MLR7", "name": "Mtmr6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486768", "map_id": "none", "name": "MTMR6:MTMR9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461099", "map_id": "none", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10490903", "map_id": "none", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10444044", "map_id": "P61209", "name": "Arf79F", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10490899", "map_id": "Q9VXV1", "name": "Dmel\\CG6299", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0030641", "map_id": "FBgn0030641", "name": "Dmel\\CG6299", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10490901", "map_id": "none", "name": "ARF1:PLEKHA3,8:PI4P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VXV1", "map_id": "Q9VXV1", "name": "Dmel\\CG6299", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486775", "map_id": "none", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10486772", "map_id": "none", "name": "MTMR6:MTMR9,MTMR8:MTMR9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10486778", "map_id": "none", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10461092", "map_id": "none", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461089", "map_id": "none", "name": "INPP5(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461154", "map_id": "none", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461151", "map_id": "none", "name": "PIK3(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10461184", "map_id": "none", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10446383", "map_id": "none", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_111627", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_425425", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10446380", "map_id": "none", "name": "Homologues of CFTR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91660", "map_id": "P91660", "name": "l(2)03659", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010549", "map_id": "FBgn0010549", "name": "l(2)03659", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q961D3", "map_id": "Q961D3", "name": "rdog", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039644", "map_id": "FBgn0039644", "name": "rdog", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGM1", "map_id": "Q9VGM1", "name": "Mrp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263316", "map_id": "FBgn0263316", "name": "Mrp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2I5", "map_id": "Q9W2I5", "name": "Dmel\\CG10505", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034612", "map_id": "FBgn0034612", "name": "Dmel\\CG10505", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MT77", "map_id": "Q8MT77", "name": "CG17338", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051793", "map_id": "FBgn0051793", "name": "CG17338", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VC63", "map_id": "Q9VC63", "name": "Cftr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039207", "map_id": "FBgn0039207", "name": "Cftr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLN6", "map_id": "Q9VLN6", "name": "Dme_CG7627", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032026", "map_id": "FBgn0032026", "name": "Dme_CG7627", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KT22", "map_id": "Q7KT22", "name": "Dme_CG9270", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032908", "map_id": "FBgn0032908", "name": "Dme_CG9270", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAN4", "map_id": "Q9VAN4", "name": "Dmel\\CG11898", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039645", "map_id": "FBgn0039645", "name": "Dmel\\CG11898", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ21", "map_id": "Q9VJ21", "name": "CG17338", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471103", "map_id": "none", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471099", "map_id": "Q9VYW4", "name": "Dmel\\CG1703", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030321", "map_id": "FBgn0030321", "name": "Dmel\\CG1703", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471101", "map_id": "none", "name": "ABCF1:EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VYW4", "map_id": "Q9VYW4", "name": "Dmel\\CG1703", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487844", "map_id": "none", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8848047", "map_id": "CHEBI:16113", "name": "CHOL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_176478", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10487841", "map_id": "Q86B52", "name": "CG8473", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "FBgn0263747", "map_id": "FBgn0263747", "name": "CG8473", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446297", "map_id": "none", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_382577", "map_id": "CHEBI:15904", "name": "LCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_382571", "map_id": "CHEBI:15904", "name": "LCFA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446294", "map_id": "none", "name": "ABCD1-3 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q7JUN3", "map_id": "Q7JUN3", "name": "ABCD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039890", "map_id": "FBgn0039890", "name": "ABCD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWC8", "map_id": "Q9VWC8", "name": "Pmp70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031069", "map_id": "FBgn0031069", "name": "Pmp70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446328", "map_id": "none", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10446326", "map_id": "none", "name": "PEX19:ABCD1/2/3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IP97", "map_id": "Q8IP97", "name": "Pex19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032407", "map_id": "FBgn0032407", "name": "Pex19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446302", "map_id": "Q9VUL8", "name": "Pex3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "FBgn0036484", "map_id": "FBgn0036484", "name": "Pex3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446324", "map_id": "Q8IP97", "name": "Pex19", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10459304", "map_id": "none", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459301", "map_id": "none", "name": "ABCG4 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VQY4", "map_id": "Q9VQY4", "name": "Atet", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020762", "map_id": "FBgn0020762", "name": "Atet", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10443719", "map_id": "none", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_265784", "map_id": "none", "name": "sterols", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:26125", "map_id": "CHEBI:26125", "name": "CHEBI:26125", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_265781", "map_id": "none", "name": "sterols", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10443716", "map_id": "none", "name": "ABCG5:ABCG8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P45843", "map_id": "P45843", "name": "st", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003515", "map_id": "FBgn0003515", "name": "st", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P12428", "map_id": "P12428", "name": "bw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000241", "map_id": "FBgn0000241", "name": "bw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0KI14", "map_id": "Q0KI14", "name": "CG18633", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051121", "map_id": "FBgn0051121", "name": "CG18633", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MRJ2", "map_id": "Q8MRJ2", "name": "Dmel\\CG11069", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039244", "map_id": "FBgn0039244", "name": "Dmel\\CG11069", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10443895", "map_id": "none", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_216762", "map_id": "CHEBI:16113", "name": "CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "false" }, { "id": "species_10443892", "map_id": "none", "name": "ABCG1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q0E8U2", "map_id": "Q0E8U2", "name": "Dmel\\CG9664", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031515", "map_id": "FBgn0031515", "name": "Dmel\\CG9664", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T9E6", "map_id": "Q8T9E6", "name": "l(2)SH2 0142", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264494", "map_id": "FBgn0264494", "name": "l(2)SH2 0142", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PBX3", "map_id": "M9PBX3", "name": "Dmel\\CG31689", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031449", "map_id": "FBgn0031449", "name": "Dmel\\CG31689", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MRL3", "map_id": "Q8MRL3", "name": "Dmel\\CG9663", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031516", "map_id": "FBgn0031516", "name": "Dmel\\CG9663", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPJ7", "map_id": "Q9VPJ7", "name": "Dmel\\CG4822", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031220", "map_id": "FBgn0031220", "name": "Dmel\\CG4822", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IPV3", "map_id": "Q8IPV3", "name": "Dmel\\CG3164", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025683", "map_id": "FBgn0025683", "name": "Dmel\\CG3164", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL61", "map_id": "Q9VL61", "name": "Dmel\\CG5853", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032167", "map_id": "FBgn0032167", "name": "Dmel\\CG5853", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTL3", "map_id": "Q9VTL3", "name": "CG7346", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052091", "map_id": "FBgn0052091", "name": "CG7346", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476387", "map_id": "none", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane" }, { "id": "species_5684863", "map_id": "none", "name": "PC, PG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_429802", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_8954401", "map_id": "CHEBI:17517", "name": "PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_5684869", "map_id": "none", "name": "PC, PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_80738", "compartment_display": "lamellar body", "complex": "true" }, { "id": "species_10476384", "map_id": "Q9VRG4", "name": "ABCA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2133233", "compartment_display": "lamellar body membrane", "complex": "false" }, { "id": "FBgn0031170", "map_id": "FBgn0031170", "name": "ABCA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459119", "map_id": "none", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1369066", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1369027", "map_id": "CHEBI:8337", "name": "porphyrin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10459116", "map_id": "none", "name": "MTABC3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9VF20", "map_id": "Q9VF20", "name": "Hmt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038376", "map_id": "FBgn0038376", "name": "Hmt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446272", "map_id": "none", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_189444", "map_id": "CHEBI:17627", "name": "heme", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113581", "map_id": "CHEBI:456216", "name": "ADP", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10446269", "map_id": "none", "name": "Heme transporters", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9W0C5", "map_id": "Q9W0C5", "name": "ABCB7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035244", "map_id": "FBgn0035244", "name": "ABCB7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476235", "map_id": "none", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10471050", "map_id": "none", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5223341", "map_id": "none", "name": "23mer peptide", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5223344", "map_id": "none", "name": "23mer peptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10471047", "map_id": "none", "name": "ABCB9 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q5BI62", "map_id": "Q5BI62", "name": "Mdr50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010241", "map_id": "FBgn0010241", "name": "Mdr50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490055", "map_id": "none", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489992", "map_id": "none", "name": "Homologues of misfolded CFTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10459319", "map_id": "none", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1131652", "map_id": "CHEBI:35703", "name": "a xenobiotic", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1467459", "map_id": "CHEBI:35703", "name": "a xenobiotic", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10459316", "map_id": "none", "name": "Homologues of ABCA8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q86B52", "map_id": "Q86B52", "name": "CG8473", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2JG15", "map_id": "X2JG15", "name": "CG32516", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0083956", "map_id": "FBgn0083956", "name": "CG32516", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490041", "map_id": "none", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10490038", "map_id": "none", "name": "misfolded CFTR:ERAD complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VQ57", "map_id": "Q9VQ57", "name": "Der-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267972", "map_id": "FBgn0267972", "name": "Der-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKC7", "map_id": "Q9VKC7", "name": "Dmel\\CG6766", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032398", "map_id": "FBgn0032398", "name": "Dmel\\CG6766", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V415", "map_id": "Q9V415", "name": "Hrd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028475", "map_id": "FBgn0028475", "name": "Hrd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXP1", "map_id": "Q9VXP1", "name": "Dmel\\CG8974", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030693", "map_id": "FBgn0030693", "name": "Dmel\\CG8974", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFY3", "map_id": "Q9VFY3", "name": "BcDNA:AT26376", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038125", "map_id": "FBgn0038125", "name": "BcDNA:AT26376", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQM1", "map_id": "Q8IQM1", "name": "Dmel\\CG32847", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052847", "map_id": "FBgn0052847", "name": "Dmel\\CG32847", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IR26", "map_id": "Q8IR26", "name": "Dmel\\CG32581", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052581", "map_id": "FBgn0052581", "name": "Dmel\\CG32581", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10490036", "map_id": "none", "name": "Ub-misfolded nascent CFTR:ERAD complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10490043", "map_id": "none", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10489994", "map_id": "none", "name": "Ub-misfolded nascent CFTR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10459297", "map_id": "none", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1454930", "map_id": "CHEBI:25696", "name": "organic anion", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1454919", "map_id": "CHEBI:25696", "name": "organic anion", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10459294", "map_id": "none", "name": "ABCCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VLP5", "map_id": "Q9VLP5", "name": "Dmel\\CG7806", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032018", "map_id": "FBgn0032018", "name": "Dmel\\CG7806", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL32", "map_id": "Q9VL32", "name": "Sur", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028675", "map_id": "FBgn0028675", "name": "Sur", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTC0", "map_id": "Q7KTC0", "name": "MRP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032456", "map_id": "FBgn0032456", "name": "MRP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10463004", "map_id": "none", "name": "Prolysyl oxidase activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10462952", "map_id": "none", "name": "Prolysyl oxidases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9W2C9", "map_id": "Q9W2C9", "name": "Loxl2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034660", "map_id": "FBgn0034660", "name": "Loxl2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9X5", "map_id": "Q9V9X5", "name": "Loxl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039848", "map_id": "FBgn0039848", "name": "Loxl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10462980", "map_id": "none", "name": "Lysyl oxidases", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10463002", "map_id": "none", "name": "Lysyl oxidase propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10462626", "map_id": "none", "name": "Procollagen C-proteinases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VC47", "map_id": "Q9VC47", "name": "tok", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004885", "map_id": "FBgn0004885", "name": "tok", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25723", "map_id": "P25723", "name": "tld", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003719", "map_id": "FBgn0003719", "name": "tld", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465381", "map_id": "none", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10459394", "map_id": "none", "name": "Collagen type XXIV fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VEP4", "map_id": "Q9VEP4", "name": "Dmel\\CG5225", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038468", "map_id": "FBgn0038468", "name": "Dmel\\CG5225", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465379", "map_id": "none", "name": "Collagen type XXIV fibre", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10459396", "map_id": "none", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10459392", "map_id": "none", "name": "Tropocollagen type XXIV", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10433228", "map_id": "none", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77308", "map_id": "CHEBI:28493", "name": "DEC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433226", "map_id": "none", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77341", "map_id": "CHEBI:28325", "name": "(S)-Hydroxydecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428444", "map_id": "none", "name": "ECHS1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q7JR58", "map_id": "Q7JR58", "name": "Echs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033879", "map_id": "FBgn0033879", "name": "Echs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10494966", "map_id": "none", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113600", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113563", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10494963", "map_id": "none", "name": "MECR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9V6U9", "map_id": "Q9V6U9", "name": "MECR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033883", "map_id": "FBgn0033883", "name": "MECR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433224", "map_id": "none", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77339", "map_id": "CHEBI:28528", "name": "3-Oxodecanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77337", "map_id": "CHEBI:15533", "name": "Octanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10433163", "map_id": "none", "name": "Trifunctional Protein", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9W1H8", "map_id": "Q9W1H8", "name": "Mtpbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025352", "map_id": "FBgn0025352", "name": "Mtpbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V397", "map_id": "Q9V397", "name": "Mtpalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028479", "map_id": "FBgn0028479", "name": "Mtpalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_390061", "map_id": "none", "name": "YKI binds to phosphorylated WTS", "reversible": "false", "notes": "The transcriptional factor Yorkie (YKI) via it's two WW domains binds to activated Warts (WTS) kinase. However, it appears that this particular binding has no detectable influence on YKI phosphorylation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390114", "map_id": "Q45VV3", "name": "YKI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_390067", "map_id": "none", "name": "Phospho HPO dimer:Phospho SAV:Phospho (2 sites) WTS:YKI:Phospho MATS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_390044", "map_id": "none", "name": "YKI is phosphorylated by and then dissociates from phosphorylated WTS", "reversible": "false", "notes": "The transcription factor Yorkie (YKI) is phosphorylated at Ser111, Ser168 and Ser250 by the activated serine/threonine kinase Warts (WTS).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390064", "map_id": "Q45VV3", "name": "Phospho YKI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_390078", "map_id": "none", "name": "14-3-3 dimer binds to phosphorylated YKI", "reversible": "false", "notes": "The phosphorylated transcription factor Yorkie (YKI) associates with either one of the two 14-3-3 dimer isoforms (14-3-3epsilon or 14-3-3zeta). This effectively anchors YKI in the cytosol and prevents it entering the nucleus to activate its target genes.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390066", "map_id": "none", "name": "14-3-3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_390163", "map_id": "none", "name": "14-3-3 dimer:Phospho YKI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10450831", "map_id": "none", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450827", "map_id": "none", "name": "GLUT1:ATP tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7KJP2", "map_id": "Q7KJP2", "name": "sut3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028561", "map_id": "FBgn0028561", "name": "sut3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0IGX4", "map_id": "Q0IGX4", "name": "Dmel\\CG7882", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033047", "map_id": "FBgn0033047", "name": "Dmel\\CG7882", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U622", "map_id": "Q9U622", "name": "sut2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028562", "map_id": "FBgn0028562", "name": "sut2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KK97", "map_id": "Q7KK97", "name": "sut1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028563", "map_id": "FBgn0028563", "name": "sut1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450825", "map_id": "none", "name": "GLUT1 / SLC2A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495569", "map_id": "none", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495566", "map_id": "none", "name": "GLUT4 / SLC2A4 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8IRI6", "map_id": "Q8IRI6", "name": "Glut1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264574", "map_id": "FBgn0264574", "name": "Glut1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450829", "map_id": "none", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10495571", "map_id": "none", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439537", "map_id": "none", "name": "GLUT2 / SLC2A2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10448859", "map_id": "none", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448856", "map_id": "none", "name": "SLC2A6,8,10,12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A8JQU1", "map_id": "A8JQU1", "name": "Dmel\\CG1208", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037386", "map_id": "FBgn0037386", "name": "Dmel\\CG1208", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQP0", "map_id": "Q9VQP0", "name": "CG15407", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053282", "map_id": "FBgn0053282", "name": "CG15407", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A1Z1CGZ4", "map_id": "A0A1Z1CGZ4", "name": "Dmel\\CG14606", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037485", "map_id": "FBgn0037485", "name": "Dmel\\CG14606", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K2U8", "map_id": "Q7K2U8", "name": "sut4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028560", "map_id": "FBgn0028560", "name": "sut4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQN6", "map_id": "Q9VQN6", "name": "Dmel\\CG15406", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031517", "map_id": "FBgn0031517", "name": "Dmel\\CG15406", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JVN6", "map_id": "Q7JVN6", "name": "CT30783", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037387", "map_id": "FBgn0037387", "name": "CT30783", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VI79", "map_id": "Q9VI79", "name": "Dmel\\CG14605", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037486", "map_id": "FBgn0037486", "name": "Dmel\\CG14605", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3S8", "map_id": "Q9W3S8", "name": "Dmel\\CG4607", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029932", "map_id": "FBgn0029932", "name": "Dmel\\CG4607", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P53403", "map_id": "P53403", "name": "Glut3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015230", "map_id": "FBgn0015230", "name": "Glut3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MLQ7", "map_id": "Q8MLQ7", "name": "Dmel\\CG4797", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034909", "map_id": "FBgn0034909", "name": "Dmel\\CG4797", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VU17", "map_id": "Q9VU17", "name": "nebu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036316", "map_id": "FBgn0036316", "name": "nebu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MKK4", "map_id": "Q8MKK4", "name": "Tret1-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033644", "map_id": "FBgn0033644", "name": "Tret1-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQP2", "map_id": "Q9VQP2", "name": "Dmel\\CG15408", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031523", "map_id": "FBgn0031523", "name": "Dmel\\CG15408", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZA52", "map_id": "A1ZA52", "name": "Dmel\\CG8249", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034045", "map_id": "FBgn0034045", "name": "Dmel\\CG8249", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IPZ9", "map_id": "Q8IPZ9", "name": "CG15407", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQP1", "map_id": "Q9VQP1", "name": "Dmel\\CG3285", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031522", "map_id": "FBgn0031522", "name": "Dmel\\CG3285", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8N1", "map_id": "A1Z8N1", "name": "Tret1-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050035", "map_id": "FBgn0050035", "name": "Tret1-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K3P6", "map_id": "Q7K3P6", "name": "Dmel\\CG6484", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034247", "map_id": "FBgn0034247", "name": "Dmel\\CG6484", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495557", "map_id": "none", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495554", "map_id": "none", "name": "GLUT14 / SLC2A14 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10471641", "map_id": "none", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471639", "map_id": "Q9VDT9", "name": "bnl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10448729", "map_id": "none", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428819", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29532", "map_id": "CHEBI:15824", "name": "Fru", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_428802", "map_id": "none", "name": "hexoses transported by GLUT7/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10448724", "map_id": "Q8IRI6", "name": "Glut1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10448760", "map_id": "none", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429078", "map_id": "none", "name": "Fru,Glc,urate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_429148", "map_id": "none", "name": "Fru,Glc,urate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10448757", "map_id": "Q8IRI6", "name": "Glut1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10495562", "map_id": "none", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495559", "map_id": "none", "name": "GLUT3 / SLC2A3 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450834", "map_id": "none", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10448879", "map_id": "none", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_264638", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_264618", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448876", "map_id": "Q9VE46", "name": "ChT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0038641", "map_id": "FBgn0038641", "name": "ChT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449996", "map_id": "none", "name": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_266029", "map_id": "CHEBI:57305", "name": "Gly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10449993", "map_id": "none", "name": "SLC6A5,9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7K330", "map_id": "Q7K330", "name": "Dmel\\CG1698", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033443", "map_id": "FBgn0033443", "name": "Dmel\\CG1698", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZBC7", "map_id": "A1ZBC7", "name": "List", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034381", "map_id": "FBgn0034381", "name": "List", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSV2", "map_id": "Q9VSV2", "name": "DmNAT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035969", "map_id": "FBgn0035969", "name": "DmNAT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8V9", "map_id": "A1Z8V9", "name": "Dmel\\CG8850", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033708", "map_id": "FBgn0033708", "name": "Dmel\\CG8850", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLY6", "map_id": "Q9VLY6", "name": "Ntl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267326", "map_id": "FBgn0267326", "name": "Ntl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLY5", "map_id": "Q9VLY5", "name": "Dmel\\CG13793", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031935", "map_id": "FBgn0031935", "name": "Dmel\\CG13793", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLY4", "map_id": "Q9VLY4", "name": "Dmel\\CG13794", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031936", "map_id": "FBgn0031936", "name": "Dmel\\CG13794", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLY3", "map_id": "Q9VLY3", "name": "Dmel\\CG13795", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031937", "map_id": "FBgn0031937", "name": "Dmel\\CG13795", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJR4", "map_id": "Q9VJR4", "name": "Dmel\\CG15279", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028886", "map_id": "FBgn0028886", "name": "Dmel\\CG15279", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTJ8", "map_id": "Q7KTJ8", "name": "Dmel\\CG33296", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053296", "map_id": "FBgn0053296", "name": "Dmel\\CG33296", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4C5", "map_id": "Q9W4C5", "name": "NAAT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029762", "map_id": "FBgn0029762", "name": "NAAT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1J0", "map_id": "Q9W1J0", "name": "GlyT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034911", "map_id": "FBgn0034911", "name": "GlyT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449963", "map_id": "none", "name": "PROT mediates L-proline uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352033", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_113538", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449960", "map_id": "none", "name": "Homologues of SLC6A7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444219", "map_id": "none", "name": "SLC6A15-mediated amino acid uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352051", "map_id": "none", "name": "ligands of SLC6A15", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29432", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29472", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:58045", "map_id": "CHEBI:58045", "name": "CHEBI:58045", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_379717", "map_id": "CHEBI:60039", "name": "L-Pro", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_351990", "map_id": "CHEBI:57926", "name": "L-Thr", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_351964", "map_id": "CHEBI:57427", "name": "L-Leu", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_379705", "map_id": "CHEBI:57844", "name": "L-Met", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6784215", "map_id": "CHEBI:18240", "name": "HPRO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29702", "map_id": "CHEBI:57762", "name": "L-Val", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_352048", "map_id": "none", "name": "ligands of SLC6A15", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10444216", "map_id": "none", "name": "Homologues of SLC6A15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8IQQ7", "map_id": "Q8IQQ7", "name": "blot", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027660", "map_id": "FBgn0027660", "name": "blot", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7Z122", "map_id": "B7Z122", "name": "Dmel\\CG10804", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029663", "map_id": "FBgn0029663", "name": "Dmel\\CG10804", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450010", "map_id": "none", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_444154", "map_id": "none", "name": "Biogenic amines transported by VMAT1/2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_380873", "map_id": "CHEBI:18243", "name": "DA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:28918", "map_id": "CHEBI:28918", "name": "CHEBI:28918", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_114523", "map_id": "CHEBI:28790", "name": "5HT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_351597", "map_id": "CHEBI:18357", "name": "NAd", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_444152", "map_id": "none", "name": "Biogenic amines transported by VMAT1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen", "complex": "true" }, { "id": "species_10450007", "map_id": "none", "name": "VMAT1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "true" }, { "id": "Q8IH57", "map_id": "Q8IH57", "name": "Vmat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260964", "map_id": "FBgn0260964", "name": "Vmat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCJ5", "map_id": "Q9VCJ5", "name": "prt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0043005", "map_id": "FBgn0043005", "name": "prt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444839", "map_id": "none", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_374935", "map_id": "CHEBI:18357", "name": "NAd", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_209789", "map_id": "CHEBI:18357", "name": "NAd", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444836", "map_id": "none", "name": "SLC22A1,SLC22A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VDS0", "map_id": "Q9VDS0", "name": "Dmel\\CG4462", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038752", "map_id": "FBgn0038752", "name": "Dmel\\CG4462", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDR9", "map_id": "Q9VDR9", "name": "Dmel\\CG4459", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038753", "map_id": "FBgn0038753", "name": "Dmel\\CG4459", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K3M6", "map_id": "Q7K3M6", "name": "Dmel\\CG8654", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034479", "map_id": "FBgn0034479", "name": "Dmel\\CG8654", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDS2", "map_id": "Q9VDS2", "name": "Dmel\\CG4465", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038750", "map_id": "FBgn0038750", "name": "Dmel\\CG4465", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D2NUL5", "map_id": "D2NUL5", "name": "CG31530-RA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264907", "map_id": "FBgn0264907", "name": "CG31530-RA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449926", "map_id": "none", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449923", "map_id": "Q7K4Y6", "name": "DAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0034136", "map_id": "FBgn0034136", "name": "DAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444198", "map_id": "none", "name": "SLC6A18 transports Gly from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444195", "map_id": "B7Z122", "name": "Dmel\\CG10804", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10445109", "map_id": "none", "name": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375468", "map_id": "none", "name": "SLC6A14 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29500", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29444", "map_id": "CHEBI:32551", "name": "L-Lys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_375459", "map_id": "none", "name": "SLC6A14 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10445106", "map_id": "none", "name": "Homologues of SLC6A14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10445044", "map_id": "none", "name": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375458", "map_id": "none", "name": "neutral amino acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29506", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29502", "map_id": "CHEBI:58095", "name": "L-Phe", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_375481", "map_id": "none", "name": "neutral amino acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10445041", "map_id": "none", "name": "Homologues of SLC6A19", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444210", "map_id": "none", "name": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444207", "map_id": "none", "name": "Homologues of SLC6A20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495345", "map_id": "none", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495342", "map_id": "none", "name": "Homologues of SLC30A10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9PEG6", "map_id": "M9PEG6", "name": "ZnT63C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035432", "map_id": "FBgn0035432", "name": "ZnT63C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPE3", "map_id": "Q9VPE3", "name": "ZnT77C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037000", "map_id": "FBgn0037000", "name": "ZnT77C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449676", "map_id": "none", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_435347", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_71067", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449673", "map_id": "P49283", "name": "Mvl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10449684", "map_id": "none", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29426", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158417", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10449681", "map_id": "Q9VPE3", "name": "ZnT77C", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10449699", "map_id": "none", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_216785", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_10449696", "map_id": "none", "name": "Homologues of SLC30A8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "Q9VKA3", "map_id": "Q9VKA3", "name": "ZnT33D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051860", "map_id": "FBgn0051860", "name": "ZnT33D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V471", "map_id": "Q9V471", "name": "ZnT35C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028516", "map_id": "FBgn0028516", "name": "ZnT35C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449823", "map_id": "none", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449820", "map_id": "none", "name": "SLC39A8-like proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VSL7", "map_id": "Q9VSL7", "name": "foi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024236", "map_id": "FBgn0024236", "name": "foi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A4IJ72", "map_id": "A4IJ72", "name": "Zip71B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036461", "map_id": "FBgn0036461", "name": "Zip71B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449831", "map_id": "none", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_442320", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10449828", "map_id": "Q9V3A4", "name": "Catsup", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0002022", "map_id": "FBgn0002022", "name": "Catsup", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449862", "map_id": "none", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449859", "map_id": "none", "name": "SLC39A1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VFA2", "map_id": "Q9VFA2", "name": "Zip88E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038312", "map_id": "FBgn0038312", "name": "Zip88E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEX1", "map_id": "Q9VEX1", "name": "Zip89B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038412", "map_id": "FBgn0038412", "name": "Zip89B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JZR2", "map_id": "Q7JZR2", "name": "Zip42C.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033096", "map_id": "FBgn0033096", "name": "Zip42C.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6P0", "map_id": "A1Z6P0", "name": "Zip42C.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033097", "map_id": "FBgn0033097", "name": "Zip42C.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449812", "map_id": "none", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449809", "map_id": "none", "name": "ZIP6/ZIP14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449712", "map_id": "none", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_437295", "map_id": "CHEBI:29036", "name": "Cu2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10449709", "map_id": "M9NE97", "name": "Ctr1A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0062413", "map_id": "FBgn0062413", "name": "Ctr1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449872", "map_id": "none", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_114632", "map_id": "CHEBI:18420", "name": "Mg2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10449867", "map_id": "A8JV32", "name": "Dmel\\CG33181", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0053181", "map_id": "FBgn0053181", "name": "Dmel\\CG33181", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450071", "map_id": "none", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10450068", "map_id": "none", "name": "CTL1-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VAP3", "map_id": "Q9VAP3", "name": "Ctl2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039637", "map_id": "FBgn0039637", "name": "Ctl2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZE7", "map_id": "Q9VZE7", "name": "Ctl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035523", "map_id": "FBgn0035523", "name": "Ctl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449579", "map_id": "none", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433138", "map_id": "CHEBI:30769", "name": "CIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10449576", "map_id": "Q9VVT2", "name": "Indy", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0036816", "map_id": "FBgn0036816", "name": "Indy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449561", "map_id": "none", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_427648", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_174375", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449558", "map_id": "none", "name": "Homologues of SLC13A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VDQ0", "map_id": "Q9VDQ0", "name": "Indy-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260466", "map_id": "FBgn0260466", "name": "Indy-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTF1", "map_id": "Q7KTF1", "name": "Dmel\\CG7309", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032314", "map_id": "FBgn0032314", "name": "Dmel\\CG7309", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JIQ7", "map_id": "E1JIQ7", "name": "CG32921-ORFB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0064119", "map_id": "FBgn0064119", "name": "CG32921-ORFB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVT2", "map_id": "Q9VVT2", "name": "Indy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449592", "map_id": "none", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449589", "map_id": "none", "name": "Homologues of SLC13A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449574", "map_id": "none", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433123", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10449571", "map_id": "none", "name": "Homologues of SLC13A3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449605", "map_id": "none", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433111", "map_id": "none", "name": "Dicarboxylates transported by NaDC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_29654", "map_id": "CHEBI:30769", "name": "CIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_433124", "map_id": "none", "name": "Dicarboxylates transported by NaDC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10449602", "map_id": "none", "name": "Homologues of SLC13A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453615", "map_id": "none", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549266", "map_id": "none", "name": "OCT2 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:46020", "map_id": "CHEBI:46020", "name": "CHEBI:46020", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:6801", "map_id": "CHEBI:6801", "name": "CHEBI:6801", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16797", "map_id": "CHEBI:16797", "name": "CHEBI:16797", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16737", "map_id": "CHEBI:16737", "name": "CHEBI:16737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:65133", "map_id": "CHEBI:65133", "name": "CHEBI:65133", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:641", "map_id": "CHEBI:641", "name": "CHEBI:641", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_351164", "map_id": "CHEBI:17431", "name": "AGM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:31941", "map_id": "CHEBI:31941", "name": "CHEBI:31941", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_549237", "map_id": "none", "name": "OCT2 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10453453", "map_id": "none", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_164988", "map_id": "CHEBI:17126", "name": "CAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_30235", "map_id": "CHEBI:17126", "name": "CAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453450", "map_id": "none", "name": "SLC22A4, 5,15,16", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VD40", "map_id": "Q9VD40", "name": "Dmel\\CG7084", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038938", "map_id": "FBgn0038938", "name": "Dmel\\CG7084", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCA0", "map_id": "Q9VCA0", "name": "Dmel\\CG6356", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039178", "map_id": "FBgn0039178", "name": "Dmel\\CG6356", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q961R9", "map_id": "Q961R9", "name": "CT19169", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038407", "map_id": "FBgn0038407", "name": "CT19169", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A2RVG5", "map_id": "A2RVG5", "name": "Dmel\\CG6006", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0063649", "map_id": "FBgn0063649", "name": "Dmel\\CG6006", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNX2", "map_id": "Q9VNX2", "name": "SLC22A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037140", "map_id": "FBgn0037140", "name": "SLC22A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNW8", "map_id": "Q9VNW8", "name": "Dmel\\CG7458", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037144", "map_id": "FBgn0037144", "name": "Dmel\\CG7458", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEY1", "map_id": "Q9VEY1", "name": "Dmel\\CG8925", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038404", "map_id": "FBgn0038404", "name": "Dmel\\CG8925", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453430", "map_id": "none", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10453654", "map_id": "none", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549255", "map_id": "none", "name": "OCT3 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:47781", "map_id": "CHEBI:47781", "name": "CHEBI:47781", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:8428", "map_id": "CHEBI:8428", "name": "CHEBI:8428", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:42820", "map_id": "CHEBI:42820", "name": "CHEBI:42820", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47499", "map_id": "CHEBI:47499", "name": "CHEBI:47499", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:46631", "map_id": "CHEBI:46631", "name": "CHEBI:46631", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_549326", "map_id": "none", "name": "OCT3 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10453455", "map_id": "Q7K3M6", "name": "Dmel\\CG8654", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10453365", "map_id": "none", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549264", "map_id": "none", "name": "OCT1 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_141324", "map_id": "CHEBI:16610", "name": "SPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "CHEBI:15854", "map_id": "CHEBI:15854", "name": "CHEBI:15854", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_141342", "map_id": "CHEBI:15746", "name": "SPN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_549250", "map_id": "none", "name": "OCT1 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10453362", "map_id": "none", "name": "OCT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453460", "map_id": "none", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10453458", "map_id": "none", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10453426", "map_id": "none", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_549261", "map_id": "CHEBI:4828", "name": "ERGT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_549260", "map_id": "CHEBI:4828", "name": "ERGT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453401", "map_id": "none", "name": "Homologues of SLC22A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10453424", "map_id": "none", "name": "Homologues of RUNX1", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453613", "map_id": "none", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_561049", "map_id": "none", "name": "OAT1-3 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:104011", "map_id": "CHEBI:104011", "name": "CHEBI:104011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_561052", "map_id": "CHEBI:2453", "name": "ACV", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_561078", "map_id": "none", "name": "OAT1-3 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_561075", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10453610", "map_id": "none", "name": "OAT1-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VDV8", "map_id": "Q9VDV8", "name": "Dmel\\CG17751", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038717", "map_id": "FBgn0038717", "name": "Dmel\\CG17751", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRQ8", "map_id": "Q9VRQ8", "name": "Dmel\\CG5592", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035645", "map_id": "FBgn0035645", "name": "Dmel\\CG5592", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDV7", "map_id": "Q9VDV7", "name": "Dmel\\CG17752", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038718", "map_id": "FBgn0038718", "name": "Dmel\\CG17752", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFG2", "map_id": "Q9VFG2", "name": "Dmel\\CG14855", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038260", "map_id": "FBgn0038260", "name": "Dmel\\CG14855", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDV6", "map_id": "Q9VDV6", "name": "Dmel\\CG16727", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038719", "map_id": "FBgn0038719", "name": "Dmel\\CG16727", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFG1", "map_id": "Q9VFG1", "name": "Dmel\\CG14856", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038261", "map_id": "FBgn0038261", "name": "Dmel\\CG14856", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDV5", "map_id": "Q9VDV5", "name": "Dmel\\CG6231", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038720", "map_id": "FBgn0038720", "name": "Dmel\\CG6231", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFG0", "map_id": "Q9VFG0", "name": "Dmel\\CG14857", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038262", "map_id": "FBgn0038262", "name": "Dmel\\CG14857", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCA2", "map_id": "Q9VCA2", "name": "Orct", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019952", "map_id": "FBgn0019952", "name": "Orct", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDW0", "map_id": "Q9VDW0", "name": "Dmel\\CG7333", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038715", "map_id": "FBgn0038715", "name": "Dmel\\CG7333", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRT4", "map_id": "Q9VRT4", "name": "CG6596", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259164", "map_id": "FBgn0259164", "name": "CG6596", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95R48", "map_id": "Q95R48", "name": "Orct2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086365", "map_id": "FBgn0086365", "name": "Orct2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDV9", "map_id": "Q9VDV9", "name": "Dmel\\CG7342", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038716", "map_id": "FBgn0038716", "name": "Dmel\\CG7342", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRR0", "map_id": "Q9VRR0", "name": "Dmel\\CG10486", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035647", "map_id": "FBgn0035647", "name": "Dmel\\CG10486", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86NP5", "map_id": "Q86NP5", "name": "CG12036", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053233", "map_id": "FBgn0053233", "name": "CG12036", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453689", "map_id": "none", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29708", "map_id": "CHEBI:422", "name": "LACT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_429056", "map_id": "CHEBI:17775", "name": "urate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_373863", "map_id": "CHEBI:422", "name": "LACT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10453686", "map_id": "none", "name": "Homologues of SLC22A12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453652", "map_id": "none", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_561071", "map_id": "none", "name": "OAT2/4 sulfate conjugate substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_176496", "map_id": "CHEBI:16814", "name": "DHEA-SO4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176501", "map_id": "CHEBI:17474", "name": "E1S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_561062", "map_id": "none", "name": "OAT2/4 sulfate conjugate substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10453649", "map_id": "none", "name": "OAT2/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449536", "map_id": "none", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_433120", "map_id": "CHEBI:17864", "name": "taurolithocholate sulfate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_176483", "map_id": "CHEBI:17864", "name": "taurolithocholate sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449533", "map_id": "none", "name": "Homologues of SLC10A6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VXV4", "map_id": "Q9VXV4", "name": "Dmel\\CG11655", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030638", "map_id": "FBgn0030638", "name": "Dmel\\CG11655", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXF5", "map_id": "Q9VXF5", "name": "Dmel\\CG9903", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030756", "map_id": "FBgn0030756", "name": "Dmel\\CG9903", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450045", "map_id": "none", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_140912", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10450042", "map_id": "M9PEN8", "name": "Rh50", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0028699", "map_id": "FBgn0028699", "name": "Rh50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450557", "map_id": "none", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10450047", "map_id": "M9PEN8", "name": "Rh50", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10450555", "map_id": "none", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10450037", "map_id": "M9PEN8", "name": "Rh50", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10450040", "map_id": "none", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10450050", "map_id": "none", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10436318", "map_id": "none", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10436315", "map_id": "none", "name": "SLC25A5,6 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q26365", "map_id": "Q26365", "name": "sesB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003360", "map_id": "FBgn0003360", "name": "sesB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62526", "map_id": "O62526", "name": "Ant2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025111", "map_id": "FBgn0025111", "name": "Ant2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433387", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179737", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:16704", "map_id": "CHEBI:16704", "name": "CHEBI:16704", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17748", "map_id": "CHEBI:17748", "name": "CHEBI:17748", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17562", "map_id": "CHEBI:17562", "name": "CHEBI:17562", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_179743", "map_id": "none", "name": "ligands of SLC28A3 & 29A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433362", "map_id": "Q9VPP0", "name": "Ent1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0031250", "map_id": "FBgn0031250", "name": "Ent1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453898", "map_id": "none", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_727782", "map_id": "none", "name": "nucleosides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_727746", "map_id": "none", "name": "nucleosides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10453895", "map_id": "Q9VPP0", "name": "Ent1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10433401", "map_id": "none", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179740", "map_id": "none", "name": "ligands of SLC28A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_179741", "map_id": "none", "name": "ligands of SLC28A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433398", "map_id": "none", "name": "Homologues of SLC28A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7K4A1", "map_id": "Q7K4A1", "name": "CNT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025709", "map_id": "FBgn0025709", "name": "CNT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7N3", "map_id": "A1Z7N3", "name": "CNT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033371", "map_id": "FBgn0033371", "name": "CNT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433385", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10433367", "map_id": "none", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179742", "map_id": "none", "name": "ligands of SLC29A2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16040", "map_id": "CHEBI:16040", "name": "CHEBI:16040", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29692", "map_id": "CHEBI:17821", "name": "Thy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29554", "map_id": "CHEBI:17568", "name": "Ura", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_179747", "map_id": "none", "name": "ligands of SLC29A2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10433360", "map_id": "Q9VPP0", "name": "Ent1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10433382", "map_id": "none", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_179738", "map_id": "none", "name": "ligands of SLC28A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_179739", "map_id": "none", "name": "ligands of SLC28A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433379", "map_id": "none", "name": "Homologues of SLC28A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453910", "map_id": "none", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_727737", "map_id": "none", "name": "ligands of SLC29A4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_727774", "map_id": "none", "name": "ligands of SLC29A4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10453890", "map_id": "Q9VU20", "name": "Ent3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0036319", "map_id": "FBgn0036319", "name": "Ent3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433365", "map_id": "none", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10453893", "map_id": "none", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10433392", "map_id": "none", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433389", "map_id": "Q7K4A1", "name": "CNT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10454262", "map_id": "none", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879559", "map_id": "none", "name": "LCFAs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:16196", "map_id": "CHEBI:16196", "name": "CHEBI:16196", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879544", "map_id": "none", "name": "LCFAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10454259", "map_id": "none", "name": "SLC27A1,4,6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453918", "map_id": "none", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_4085435", "map_id": "CHEBI:16556", "name": "CMP-Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_109395", "map_id": "CHEBI:17361", "name": "CMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453915", "map_id": "O76865", "name": "Ugalt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0024994", "map_id": "FBgn0024994", "name": "Ugalt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453946", "map_id": "none", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742368", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_205683", "map_id": "CHEBI:17009", "name": "GDP-Fuc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10453943", "map_id": "Q9VHT4", "name": "nac", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0265351", "map_id": "FBgn0265351", "name": "nac", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453962", "map_id": "none", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_162860", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_744239", "map_id": "CHEBI:17345", "name": "guanosine 5'-monophosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_113578", "map_id": "CHEBI:17345", "name": "GMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_744233", "map_id": "CHEBI:15820", "name": "GDP-Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10453957", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_742353", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_742361", "map_id": "CHEBI:16082", "name": "UDP-Xyl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10453951", "map_id": "Q9W429", "name": "Efr", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0029849", "map_id": "FBgn0029849", "name": "Efr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453923", "map_id": "none", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_735692", "map_id": "none", "name": "UDP-Gal, UDP-GalNAc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_735691", "map_id": "none", "name": "UDP-Gal, UDP-GalNAc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10453920", "map_id": "O76865", "name": "Ugalt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10453938", "map_id": "none", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_158471", "map_id": "CHEBI:17980", "name": "PAPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453935", "map_id": "none", "name": "SLC35B2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VVD9", "map_id": "Q9VVD9", "name": "Papst2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036695", "map_id": "FBgn0036695", "name": "Papst2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEI3", "map_id": "Q9VEI3", "name": "sll", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038524", "map_id": "FBgn0038524", "name": "sll", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453954", "map_id": "none", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10453906", "map_id": "none", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_727753", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10453903", "map_id": "A0A4D6K3L8", "name": "Dmel\\CG9706", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0036662", "map_id": "FBgn0036662", "name": "Dmel\\CG9706", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454239", "map_id": "none", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879603", "map_id": "none", "name": "T3,T4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_352326", "map_id": "CHEBI:18332", "name": "T4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_176667", "map_id": "CHEBI:28774", "name": "T3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_879628", "map_id": "none", "name": "T3,T4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10454236", "map_id": "none", "name": "SLCOs, SLC16A2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VLB3", "map_id": "Q9VLB3", "name": "Oatp30B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032123", "map_id": "FBgn0032123", "name": "Oatp30B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C8VV48", "map_id": "C8VV48", "name": "kar", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001296", "map_id": "FBgn0001296", "name": "kar", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W270", "map_id": "Q9W270", "name": "Oatp58Db", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034715", "map_id": "FBgn0034715", "name": "Oatp58Db", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK82", "map_id": "Q9VK82", "name": "Oatp33Eb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032435", "map_id": "FBgn0032435", "name": "Oatp33Eb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W269", "map_id": "Q9W269", "name": "Oatp58Dc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034716", "map_id": "FBgn0034716", "name": "Oatp58Dc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SY02", "map_id": "Q8SY02", "name": "Oatp26F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051634", "map_id": "FBgn0051634", "name": "Oatp26F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVH9", "map_id": "Q9VVH9", "name": "Oatp74D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036732", "map_id": "FBgn0036732", "name": "Oatp74D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W271", "map_id": "Q9W271", "name": "Oatp58Da", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050277", "map_id": "FBgn0050277", "name": "Oatp58Da", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK84", "map_id": "Q9VK84", "name": "Oatp33Ea", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032433", "map_id": "FBgn0032433", "name": "Oatp33Ea", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454189", "map_id": "none", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879553", "map_id": "none", "name": "SLCO2B1 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:63836", "map_id": "CHEBI:63836", "name": "CHEBI:63836", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_879654", "map_id": "none", "name": "SLCO2B1 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10454186", "map_id": "Q9VLB3", "name": "Oatp30B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10454267", "map_id": "none", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879521", "map_id": "CHEBI:4551", "name": "DIGX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_879517", "map_id": "CHEBI:4551", "name": "DIGX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10454264", "map_id": "Q8SY02", "name": "Oatp26F", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10497799", "map_id": "none", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10454191", "map_id": "Q9VLB3", "name": "Oatp30B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10454184", "map_id": "none", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_879566", "map_id": "none", "name": "PGT substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:15544", "map_id": "CHEBI:15544", "name": "CHEBI:15544", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_416911", "map_id": "CHEBI:15555", "name": "PGD2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_879614", "map_id": "none", "name": "PGT substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10454181", "map_id": "Q9VLB3", "name": "Oatp30B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10448447", "map_id": "none", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428027", "map_id": "none", "name": "L-Glu,L-Asp,D-Asp", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_6810061", "map_id": "CHEBI:17364", "name": "D-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_427997", "map_id": "none", "name": "L-Glu,L-Asp,D-Asp", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10442846", "map_id": "E1JHQ6", "name": "Eaat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0026438", "map_id": "FBgn0026438", "name": "Eaat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448637", "map_id": "none", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428592", "map_id": "none", "name": "Inhibitory amino acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_428548", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_428632", "map_id": "none", "name": "Inhibitory amino acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "true" }, { "id": "species_10448634", "map_id": "A1Z9M6", "name": "VGAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "false" }, { "id": "FBgn0033911", "map_id": "FBgn0033911", "name": "VGAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474318", "map_id": "none", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_209785", "map_id": "CHEBI:16382", "name": "I-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_209818", "map_id": "CHEBI:16382", "name": "I-", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10474315", "map_id": "Q9VVM6", "name": "Prestin", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0036770", "map_id": "FBgn0036770", "name": "Prestin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448410", "map_id": "none", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448405", "map_id": "Q9VVM6", "name": "Prestin", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10448393", "map_id": "none", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448390", "map_id": "Q9VVM6", "name": "Prestin", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10448388", "map_id": "none", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448383", "map_id": "Q9VVM6", "name": "Prestin", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10491197", "map_id": "none", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491194", "map_id": "Q7K155", "name": "Dmel\\CG6928", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0036240", "map_id": "FBgn0036240", "name": "Dmel\\CG6928", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491278", "map_id": "none", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8876310", "map_id": "none", "name": "LACT, PYR, NCA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_113557", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8869604", "map_id": "CHEBI:32544", "name": "NCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8876304", "map_id": "none", "name": "LACT, PYR, NCA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_197230", "map_id": "CHEBI:15940", "name": "NCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10491275", "map_id": "none", "name": "Homologues of SLC5A12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P83740", "map_id": "P83740", "name": "SLC5A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052669", "map_id": "FBgn0052669", "name": "SLC5A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SWV5", "map_id": "Q8SWV5", "name": "dSLC5A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034494", "map_id": "FBgn0034494", "name": "dSLC5A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489060", "map_id": "none", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2162252", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162265", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10489057", "map_id": "Q9VBN7", "name": "SLC25A26", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0039357", "map_id": "FBgn0039357", "name": "SLC25A26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448403", "map_id": "none", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448398", "map_id": "Q9VTG0", "name": "NaPi-III", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0260795", "map_id": "FBgn0260795", "name": "NaPi-III", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448445", "map_id": "none", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428037", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:90799", "map_id": "CHEBI:90799", "name": "CHEBI:90799", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47923", "map_id": "CHEBI:47923", "name": "CHEBI:47923", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_428026", "map_id": "none", "name": "Di-peptides/tri-peptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10448442", "map_id": "X2JCG8", "name": "CG32780", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0028491", "map_id": "FBgn0028491", "name": "CG32780", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471671", "map_id": "none", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428040", "map_id": "CHEBI:15378", "name": "H+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_5673778", "map_id": "CHEBI:16283", "name": "CySS-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_379444", "map_id": "CHEBI:16283", "name": "CySS-", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10471668", "map_id": "Q9VCR7", "name": "CTNS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "FBgn0039045", "map_id": "FBgn0039045", "name": "CTNS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448940", "map_id": "none", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448934", "map_id": "Q8SWV5", "name": "dSLC5A3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10448937", "map_id": "none", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429739", "map_id": "none", "name": "monocarboxylates transported by SLC5A8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:30772", "map_id": "CHEBI:30772", "name": "CHEBI:30772", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29416", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:30768", "map_id": "CHEBI:30768", "name": "CHEBI:30768", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_429748", "map_id": "none", "name": "monocarboxylates transported by SLC5A8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10448456", "map_id": "none", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane" }, { "id": "species_428614", "map_id": "CHEBI:29985", "name": "L-Glu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20600", "compartment_display": "synaptic vesicle", "complex": "false" }, { "id": "species_10448449", "map_id": "Q9VQC0", "name": "VGlut", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_201753", "compartment_display": "synaptic vesicle membrane", "complex": "false" }, { "id": "FBgn0031424", "map_id": "FBgn0031424", "name": "VGlut", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448871", "map_id": "none", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442820", "map_id": "none", "name": "Homologues of SLC5A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10448629", "map_id": "none", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_428639", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_428633", "map_id": "CHEBI:17012", "name": "Neu5Ac", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448626", "map_id": "Q9VYG7", "name": "MFS10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "FBgn0030452", "map_id": "FBgn0030452", "name": "MFS10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491181", "map_id": "none", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491178", "map_id": "none", "name": "SLC25A18,A22", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VGF7", "map_id": "Q9VGF7", "name": "GC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260743", "map_id": "FBgn0260743", "name": "GC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8INJ3", "map_id": "Q8INJ3", "name": "GC2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037970", "map_id": "FBgn0037970", "name": "GC2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460673", "map_id": "none", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_198498", "map_id": "CHEBI:30797", "name": "MAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614584", "map_id": "CHEBI:16189", "name": "SO4(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113544", "map_id": "CHEBI:30797", "name": "MAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10444381", "map_id": "Q9Y166", "name": "Dic1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0027610", "map_id": "FBgn0027610", "name": "Dic1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444384", "map_id": "none", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10445035", "map_id": "none", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375400", "map_id": "none", "name": "ligands of SLC36A1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375411", "map_id": "none", "name": "ligands of SLC36A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10445032", "map_id": "Q9VLM3", "name": "Dmel\\CG13384", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0032036", "map_id": "FBgn0032036", "name": "Dmel\\CG13384", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445030", "map_id": "none", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375409", "map_id": "none", "name": "Gly, L-Pro", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375414", "map_id": "none", "name": "Gly, L-Pro", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10445027", "map_id": "none", "name": "Homologues of SLC36A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9PEU1", "map_id": "M9PEU1", "name": "CG34239", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263776", "map_id": "FBgn0263776", "name": "CG34239", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K2W3", "map_id": "Q7K2W3", "name": "Dmel\\CG8785", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033760", "map_id": "FBgn0033760", "name": "Dmel\\CG8785", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VT04", "map_id": "Q9VT04", "name": "path", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036007", "map_id": "FBgn0036007", "name": "path", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX84", "map_id": "Q9VX84", "name": "Dmel\\CG16700", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030816", "map_id": "FBgn0030816", "name": "Dmel\\CG16700", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V5R4", "map_id": "Q4V5R4", "name": "polyph", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033572", "map_id": "FBgn0033572", "name": "polyph", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLM3", "map_id": "Q9VLM3", "name": "Dmel\\CG13384", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTD7", "map_id": "Q9VTD7", "name": "Dmel\\CG7888", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036116", "map_id": "FBgn0036116", "name": "Dmel\\CG7888", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PHT8", "map_id": "M9PHT8", "name": "CT15971", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030817", "map_id": "FBgn0030817", "name": "CT15971", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQF3", "map_id": "Q8IQF3", "name": "FBgn 52081", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052081", "map_id": "FBgn0052081", "name": "FBgn 52081", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTD5", "map_id": "Q9VTD5", "name": "CG11806", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052079", "map_id": "FBgn0052079", "name": "CG11806", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W056", "map_id": "Q9W056", "name": "SLC36A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035300", "map_id": "FBgn0035300", "name": "SLC36A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448095", "map_id": "none", "name": "SLC4A1,2,3 exchanges HCO3- for Cl-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448088", "map_id": "Q9VT48", "name": "Ae2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0036043", "map_id": "FBgn0036043", "name": "Ae2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448107", "map_id": "none", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448100", "map_id": "Q8IPI3", "name": "Ndae1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10491757", "map_id": "none", "name": "SLC4A4 cotransports Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10491752", "map_id": "Q8IPI3", "name": "Ndae1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10491755", "map_id": "Q9VZX9", "name": "AhcyL1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10448114", "map_id": "none", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448109", "map_id": "Q8IPI3", "name": "Ndae1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10474206", "map_id": "none", "name": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_5626313", "map_id": "CHEBI:29103", "name": "K+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10474203", "map_id": "none", "name": "Homologues of SLC24A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q9VN12", "map_id": "Q9VN12", "name": "SLC24A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037238", "map_id": "FBgn0037238", "name": "SLC24A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7PLW4", "map_id": "Q7PLW4", "name": "CG40146", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039941", "map_id": "FBgn0039941", "name": "CG40146", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5LJX8", "map_id": "Q5LJX8", "name": "zyd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265767", "map_id": "FBgn0265767", "name": "zyd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8Y5A2", "map_id": "A8Y5A2", "name": "Dmel\\CG12061", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040031", "map_id": "FBgn0040031", "name": "Dmel\\CG12061", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448158", "map_id": "none", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_425815", "map_id": "CHEBI:49713", "name": "Li+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_425810", "map_id": "CHEBI:49713", "name": "Li+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10448155", "map_id": "A1Z7I1", "name": "Dmel\\CG14744", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0033324", "map_id": "FBgn0033324", "name": "Dmel\\CG14744", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448150", "map_id": "none", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448147", "map_id": "none", "name": "SLC24A1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9U6A0", "map_id": "Q9U6A0", "name": "Nckx30C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028704", "map_id": "FBgn0028704", "name": "Nckx30C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444254", "map_id": "none", "name": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352036", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_212615", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10444251", "map_id": "E1JHQ6", "name": "Eaat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10445150", "map_id": "none", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_375765", "map_id": "none", "name": "L-Arg, L-Lys, L-Orn", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_375781", "map_id": "none", "name": "L-Arg, L-Lys, L-Orn", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10445126", "map_id": "none", "name": "Homologues of SLC7A2-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VNP7", "map_id": "Q9VNP7", "name": "slif", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037203", "map_id": "FBgn0037203", "name": "slif", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2PDY3", "map_id": "Q2PDY3", "name": "Dmel\\CG7255", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036493", "map_id": "FBgn0036493", "name": "Dmel\\CG7255", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVM0", "map_id": "Q9VVM0", "name": "anon-WO0118547.111", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036764", "map_id": "FBgn0036764", "name": "anon-WO0118547.111", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445148", "map_id": "none", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10445145", "map_id": "none", "name": "Homologues of SLC7A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495333", "map_id": "none", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8959777", "map_id": "none", "name": "SLC25A29 substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28229", "map_id": "CHEBI:28229", "name": "CHEBI:28229", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_113585", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "CHEBI:27747", "map_id": "CHEBI:27747", "name": "CHEBI:27747", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8959775", "map_id": "none", "name": "SLC25A29 substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10495330", "map_id": "Q9VKZ5", "name": "Dmel\\CG4995", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0032219", "map_id": "FBgn0032219", "name": "Dmel\\CG4995", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444249", "map_id": "none", "name": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352355", "map_id": "none", "name": "alanine, serine, threonine, or cysteine", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_352000", "map_id": "CHEBI:57926", "name": "L-Thr", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_352359", "map_id": "none", "name": "alanine, serine, threonine, or cysteine", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10444240", "map_id": "E1JHQ6", "name": "Eaat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10445650", "map_id": "none", "name": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_29588", "map_id": "CHEBI:57427", "name": "L-Leu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_379430", "map_id": "none", "name": "L-Arg, CySS-, L-Lys", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_379440", "map_id": "none", "name": "L-Arg, CySS-, L-Lys", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10445647", "map_id": "none", "name": "SLC7A9:SLC3A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8IR48", "map_id": "Q8IR48", "name": "sbm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030574", "map_id": "FBgn0030574", "name": "sbm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7E8", "map_id": "A1Z7E8", "name": "Mal-A4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033294", "map_id": "FBgn0033294", "name": "Mal-A4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7F3", "map_id": "A1Z7F3", "name": "Mal-A8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033297", "map_id": "FBgn0033297", "name": "Mal-A8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07192", "map_id": "P07192", "name": "Mal-A3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002571", "map_id": "FBgn0002571", "name": "Mal-A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4P1SA55", "map_id": "A0A4P1SA55", "name": "Mal-B2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032382", "map_id": "FBgn0032382", "name": "Mal-B2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7F2", "map_id": "A1Z7F2", "name": "Mal-A7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033296", "map_id": "FBgn0033296", "name": "Mal-A7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07191", "map_id": "P07191", "name": "Mal-A2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002569", "map_id": "FBgn0002569", "name": "Mal-A2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKE6", "map_id": "Q9VKE6", "name": "Mal-B1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032381", "map_id": "FBgn0032381", "name": "Mal-B1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7F1", "map_id": "A1Z7F1", "name": "Mal-A6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050360", "map_id": "FBgn0050360", "name": "Mal-A6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P07190", "map_id": "P07190", "name": "Mal-A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002570", "map_id": "FBgn0002570", "name": "Mal-A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5U124", "map_id": "Q5U124", "name": "Mal-A5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050359", "map_id": "FBgn0050359", "name": "Mal-A5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445137", "map_id": "none", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10445134", "map_id": "Q9I7L6", "name": "tadr", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0032911", "map_id": "FBgn0032911", "name": "tadr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490484", "map_id": "none", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490478", "map_id": "none", "name": "Homologues of SLC36A4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10445129", "map_id": "none", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10444227", "map_id": "none", "name": "SLC16A10-mediated uptake of aromatic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352161", "map_id": "none", "name": "ligands of SLC16A10", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_352139", "map_id": "none", "name": "ligands of SLC16A10", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10444224", "map_id": "C8VV48", "name": "kar", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10431078", "map_id": "none", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10431074", "map_id": "Q9V9M6", "name": "Tif-IA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0032988", "map_id": "FBgn0032988", "name": "Tif-IA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10431069", "map_id": "none", "name": "RNA Polymerase I Holoenzyme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P20028", "map_id": "P20028", "name": "RpI135", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003278", "map_id": "FBgn0003278", "name": "RpI135", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VD81", "map_id": "Q9VD81", "name": "RpI12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038903", "map_id": "FBgn0038903", "name": "RpI12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM72", "map_id": "Q9VM72", "name": "BEST:GH23590", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042092", "map_id": "FBgn0042092", "name": "BEST:GH23590", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VE94", "map_id": "Q9VE94", "name": "Dmel\\CG18600", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038601", "map_id": "FBgn0038601", "name": "Dmel\\CG18600", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91875", "map_id": "P91875", "name": "RpI1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019938", "map_id": "FBgn0019938", "name": "RpI1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10431076", "map_id": "none", "name": "Active RNA Polymerase I", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V9M6", "map_id": "Q9V9M6", "name": "Tif-IA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431182", "map_id": "none", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10431176", "map_id": "none", "name": "RNA Polymerase I Transcription Initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VPX4", "map_id": "Q9VPX4", "name": "Tfb4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031309", "map_id": "FBgn0031309", "name": "Tfb4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KPG8", "map_id": "Q7KPG8", "name": "Mat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024956", "map_id": "FBgn0024956", "name": "Mat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76513", "map_id": "O76513", "name": "CycH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022936", "map_id": "FBgn0022936", "name": "CycH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24216", "map_id": "Q24216", "name": "Cdk7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263237", "map_id": "FBgn0263237", "name": "Cdk7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7Z018", "map_id": "B7Z018", "name": "Tfb5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265968", "map_id": "FBgn0265968", "name": "Tfb5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNP8", "map_id": "Q9VNP8", "name": "Ssl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037202", "map_id": "FBgn0037202", "name": "Ssl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KVP9", "map_id": "Q7KVP9", "name": "Xpd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261850", "map_id": "FBgn0261850", "name": "Xpd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUR1", "map_id": "Q9VUR1", "name": "mrn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261109", "map_id": "FBgn0261109", "name": "mrn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02870", "map_id": "Q02870", "name": "hay", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001179", "map_id": "FBgn0001179", "name": "hay", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q960E8", "map_id": "Q960E8", "name": "Tfb1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033929", "map_id": "FBgn0033929", "name": "Tfb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH20", "map_id": "Q9VH20", "name": "TAF1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037792", "map_id": "FBgn0037792", "name": "TAF1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10431180", "map_id": "none", "name": "RNA Polymerase I promoter escape complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10431966", "map_id": "none", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_350", "compartment_display": "nucleolus" }, { "id": "species_74985", "map_id": "none", "name": "elongating pre-rRNA transcript", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_30595", "map_id": "none", "name": "NTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110577", "map_id": "CHEBI:17677", "name": "CTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10457357", "map_id": "none", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457269", "map_id": "Q9VKI0", "name": "cmet", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0040232", "map_id": "FBgn0040232", "name": "cmet", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457271", "map_id": "none", "name": "CENP-E dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VKI0", "map_id": "Q9VKI0", "name": "cmet", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457355", "map_id": "none", "name": "Chromokinesins form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450203", "map_id": "Q9XZ29", "name": "Klp3A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0011606", "map_id": "FBgn0011606", "name": "Klp3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457237", "map_id": "none", "name": "Kinesin-4 homodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XZ29", "map_id": "Q9XZ29", "name": "Klp3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457353", "map_id": "none", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457250", "map_id": "none", "name": "Kinesin-6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VZF5", "map_id": "Q9VZF5", "name": "pav", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457255", "map_id": "A1Z9I5", "name": "tum", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0086356", "map_id": "FBgn0086356", "name": "tum", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457257", "map_id": "none", "name": "Centralspindlin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1Z9I5", "map_id": "A1Z9I5", "name": "tum", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457208", "map_id": "none", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457202", "map_id": "P17210", "name": "Khc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0001308", "map_id": "FBgn0001308", "name": "Khc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457191", "map_id": "P46824", "name": "Klc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0010235", "map_id": "FBgn0010235", "name": "Klc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457206", "map_id": "none", "name": "Kinesin-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P46824", "map_id": "P46824", "name": "Klc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17210", "map_id": "P17210", "name": "Khc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457351", "map_id": "none", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457242", "map_id": "P46863", "name": "Klp61F", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0004378", "map_id": "FBgn0004378", "name": "Klp61F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457244", "map_id": "none", "name": "Kinesin-5 homotetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P46863", "map_id": "P46863", "name": "Klp61F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457365", "map_id": "none", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457363", "map_id": "none", "name": "Kinesin-13 monomers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W1U4", "map_id": "Q9W1U4", "name": "Klp59C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034824", "map_id": "FBgn0034824", "name": "Klp59C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1U1", "map_id": "Q9W1U1", "name": "Klp59D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034827", "map_id": "FBgn0034827", "name": "Klp59D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q960Z0", "map_id": "Q960Z0", "name": "Klp10A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030268", "map_id": "FBgn0030268", "name": "Klp10A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457311", "map_id": "none", "name": "Kinesin-13 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457349", "map_id": "none", "name": "Kinesins move along microtubules consuming ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457347", "map_id": "none", "name": "Kinesins:microtubule", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VLW2", "map_id": "Q9VLW2", "name": "KIF26A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031955", "map_id": "FBgn0031955", "name": "KIF26A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRK9", "map_id": "Q9VRK9", "name": "Klp64D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004380", "map_id": "FBgn0004380", "name": "Klp64D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZ07", "map_id": "Q9VZ07", "name": "Kap3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028421", "map_id": "FBgn0028421", "name": "Kap3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46867", "map_id": "P46867", "name": "Klp68D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004381", "map_id": "FBgn0004381", "name": "Klp68D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSW5", "map_id": "Q9VSW5", "name": "Klp67A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004379", "map_id": "FBgn0004379", "name": "Klp67A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457361", "map_id": "none", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457359", "map_id": "none", "name": "Kinesin-3 monomers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10457233", "map_id": "none", "name": "Kinesin-3 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10450651", "map_id": "none", "name": "Caspase-1 active tetramer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450627", "map_id": "none", "name": "CASP1(120-197):CASP1(317-404)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XYF4", "map_id": "Q9XYF4", "name": "phospho-Dronc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026404", "map_id": "FBgn0026404", "name": "phospho-Dronc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRY7", "map_id": "Q8IRY7", "name": "phospho-Dredd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-Dredd", "map_id": "phospho-Dredd", "name": "phospho-Dredd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450649", "map_id": "none", "name": "Caspase-1 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10450629", "map_id": "none", "name": "Formation of caspase-1 p10/p20 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450625", "map_id": "none", "name": "Homologues of CASP1(120-297)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10450619", "map_id": "none", "name": "Homologues of CASP1(317-404)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10442686", "map_id": "none", "name": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442681", "map_id": "none", "name": "NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10442683", "map_id": "none", "name": "BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10451597", "map_id": "none", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451588", "map_id": "none", "name": "hp-IRAK1: p-Pellino-1,2,(3):UBE2N:UBE2V1:K63polyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VJS5", "map_id": "Q9VJS5", "name": "Dmel\\CG3473", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028913", "map_id": "FBgn0028913", "name": "Dmel\\CG3473", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGD6", "map_id": "Q9VGD6", "name": "Dmel\\CG14739", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037987", "map_id": "FBgn0037987", "name": "Dmel\\CG14739", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35128", "map_id": "P35128", "name": "ben", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ben", "map_id": "ben", "name": "ben", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRL1", "map_id": "Q9VRL1", "name": "Uev1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Uev1A", "map_id": "Uev1A", "name": "Uev1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O77237", "map_id": "O77237", "name": "phospho-Pli", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025574", "map_id": "FBgn0025574", "name": "phospho-Pli", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10451594", "map_id": "none", "name": "K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10442695", "map_id": "none", "name": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442679", "map_id": "none", "name": "NFKB1(1-433):RELA:p-S32,S36-NFKBIA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10442693", "map_id": "none", "name": "IKBA is phosphorylated by Phospho IKKB kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437421", "map_id": "Q03017", "name": "phospho-cact", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442690", "map_id": "Q9VEZ5", "name": "phospho-IKKbeta", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10450611", "map_id": "none", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450601", "map_id": "none", "name": "hp-IRAK1:3xTRAF6:3xUBE2N:UBE2V1:K63polyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10450608", "map_id": "none", "name": "hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10442673", "map_id": "none", "name": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442671", "map_id": "none", "name": "NFKB1:RELA:p-S32,S36-NFKBIA:Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495861", "map_id": "none", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10496003", "map_id": "none", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495728", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10495919", "map_id": "none", "name": "TBK1 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455277", "map_id": "Q9V3Y8", "name": "IKKepsilon", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0086657", "map_id": "FBgn0086657", "name": "phospho-IKKepsilon", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495917", "map_id": "Q9V3Y8", "name": "phospho-IKKepsilon", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10460539", "map_id": "none", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605716", "map_id": "CHEBI:18313", "name": "Gb3Cer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605601", "map_id": "CHEBI:17950", "name": "LacCer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10460536", "map_id": "none", "name": "GLA dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q7K127", "map_id": "Q7K127", "name": "Dmel\\CG7997", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034117", "map_id": "FBgn0034117", "name": "Dmel\\CG7997", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL27", "map_id": "Q9VL27", "name": "Dmel\\CG5731", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032192", "map_id": "FBgn0032192", "name": "Dmel\\CG5731", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460569", "map_id": "none", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_429776", "map_id": "CHEBI:17636", "name": "SPHM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1610735", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10460566", "map_id": "none", "name": "SMPD2,3:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VZS6", "map_id": "Q9VZS6", "name": "nSMase", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035421", "map_id": "FBgn0035421", "name": "nSMase", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460472", "map_id": "none", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_1605592", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605745", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605673", "map_id": "CHEBI:52639", "name": "CERA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10460469", "map_id": "none", "name": "GBA:SAPC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q9Y125", "map_id": "Q9Y125", "name": "Sap-r", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000416", "map_id": "FBgn0000416", "name": "Sap-r", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IMY3", "map_id": "Q8IMY3", "name": "Gba1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051414", "map_id": "FBgn0051414", "name": "Gba1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460822", "map_id": "none", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1638840", "map_id": "CHEBI:16197", "name": "C1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10460819", "map_id": "Q9VNA6", "name": "Cerk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0037315", "map_id": "FBgn0037315", "name": "Cerk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460591", "map_id": "none", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1861754", "map_id": "CHEBI:33575", "name": "RCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10460588", "map_id": "none", "name": "ASAH2-like proteins", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10460814", "map_id": "none", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_1660674", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10460811", "map_id": "Q9W297", "name": "GlcT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0067102", "map_id": "FBgn0067102", "name": "GlcT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461805", "map_id": "none", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1861764", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_194377", "map_id": "CHEBI:52639", "name": "N-acylsphingosine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10461802", "map_id": "Q9VV98", "name": "Dmel\\CG9701", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10491828", "map_id": "none", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8879102", "map_id": "CHEBI:18313", "name": "Gb3Cer", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_8879101", "map_id": "CHEBI:18259", "name": "Gb4Cer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10491825", "map_id": "Q24157", "name": "brn", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10460522", "map_id": "none", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605608", "map_id": "CHEBI:61360", "name": "Globoside", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10460519", "map_id": "none", "name": "HEXA,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10471658", "map_id": "none", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5339515", "map_id": "CHEBI:16197", "name": "C1P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10471655", "map_id": "Q8MLW4", "name": "Dmel\\CG30392", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0050392", "map_id": "FBgn0050392", "name": "Dmel\\CG30392", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461800", "map_id": "none", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1861782", "map_id": "CHEBI:18368", "name": "Glucosylceramide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10461797", "map_id": "Q7KT91", "name": "GBA2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0028916", "map_id": "FBgn0028916", "name": "GBA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460581", "map_id": "none", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10460644", "map_id": "none", "name": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_194653", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10460622", "map_id": "none", "name": "ARS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q8SZ72", "map_id": "Q8SZ72", "name": "Dmel\\CG8646", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033763", "map_id": "FBgn0033763", "name": "Dmel\\CG8646", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQS4", "map_id": "Q8IQS4", "name": "CG5584", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052191", "map_id": "FBgn0052191", "name": "CG5584", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVM4", "map_id": "Q9VVM4", "name": "Dmel\\CG7402", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036768", "map_id": "FBgn0036768", "name": "Dmel\\CG7402", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVM1", "map_id": "Q9VVM1", "name": "Dmel\\CG7408", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036765", "map_id": "FBgn0036765", "name": "Dmel\\CG7408", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460641", "map_id": "none", "name": "active ARS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_1663154", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_194697", "map_id": "CHEBI:57945", "name": "NADH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10460596", "map_id": "Q9W0U6", "name": "Dmel\\CG7049", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "FBgn0035102", "map_id": "FBgn0035102", "name": "Dmel\\CG7049", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460547", "map_id": "none", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605713", "map_id": "CHEBI:17636", "name": "SPHM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1605750", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10460544", "map_id": "D6W4U0", "name": "CG3376-RA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0034997", "map_id": "FBgn0034997", "name": "CG3376-RA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460579", "map_id": "none", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_1606283", "map_id": "CHEBI:17636", "name": "SPHM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1606280", "map_id": "CHEBI:18132", "name": "ChoP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10460576", "map_id": "none", "name": "SMPD4:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VGH0", "map_id": "Q9VGH0", "name": "Dmel\\CG6962", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037958", "map_id": "FBgn0037958", "name": "Dmel\\CG6962", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471683", "map_id": "none", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5340315", "map_id": "CHEBI:24402", "name": "GSL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5340299", "map_id": "CHEBI:24402", "name": "GSL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10471680", "map_id": "Q9VXV1", "name": "Dmel\\CG6299", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10479745", "map_id": "none", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29452", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6785915", "map_id": "CHEBI:18390", "name": "GalCer", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_110096", "map_id": "CHEBI:17659", "name": "UDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479742", "map_id": "Q9VGT4", "name": "Ugt302E1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0040257", "map_id": "FBgn0040257", "name": "Ugt302E1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460480", "map_id": "none", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_1605677", "map_id": "CHEBI:61048", "name": "GM1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_1605610", "map_id": "CHEBI:51013", "name": "GM2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_209094", "map_id": "none", "name": "Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex'", "reversible": "false", "notes": "The bound and phosphorylated Armadillo (ARM) is ubiquitated by the ubiquitin ligase assembled complex, whether this occurs when ARM is bound to the 'destruction complex' or after it has dissociated from it is unclear. The interaction between Slimb (SLMB) and ARM has weakened the latter's binding to the scaffolding molecules in the 'destruction complex'. ARM and the bound ubiquitin ligase assembled complex dissociate from Axin (AXN), APC (APC/APC2) and also from each other to leave free ubiquitinated and phosphorylated ARM which is now marked for degradation by the 26S proteasome.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206991", "map_id": "none", "name": "UBI-P63E:Phospho (4 sites) ARM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209129", "map_id": "none", "name": "Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex", "reversible": "false", "notes": "The free ubiquitinated and phosphorylated Armadillo (ARM) is now targeted by the 26S proteasome which binds and then degrades it. The cytoplasmic concentration of Armadillo is now reduced.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_209102", "map_id": "none", "name": "SLMB binds to phosphorylated ARM to form the 'destruction complex'", "reversible": "false", "notes": "The phosphorylated Armadillo (ARM) is now recognised and bound by the F-box protein Slimb (SLMB), in the E3 ubiquitin ligase assembled complex additionally containing the S-phase kinase-associated protein SKPA, the Cullin orthologue, LIN19, the Ring-box protein containg ROC1A, and the ubiquitin-conjugating enzyme orthologue EFF.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10459100", "map_id": "none", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458007", "map_id": "Q24472", "name": "Rbf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10459084", "map_id": "none", "name": "Cyclin E/A:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10459098", "map_id": "none", "name": "RBL1:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24472", "map_id": "Q24472", "name": "Rbf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rbf", "map_id": "Rbf", "name": "Rbf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458025", "map_id": "none", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458009", "map_id": "none", "name": "RBL1:E2F4:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24318", "map_id": "Q24318", "name": "Dp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011763", "map_id": "FBgn0011763", "name": "Dp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O77051", "map_id": "O77051", "name": "E2f2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024371", "map_id": "FBgn0024371", "name": "E2f2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458023", "map_id": "none", "name": "HDAC1:RBL1:E2F4:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10459096", "map_id": "none", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10459094", "map_id": "none", "name": "RBL1:E2F4:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458999", "map_id": "none", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458995", "map_id": "none", "name": "p-MuvB complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7K159", "map_id": "Q7K159", "name": "mip40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034430", "map_id": "FBgn0034430", "name": "mip40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W482", "map_id": "Q9W482", "name": "lin-52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029800", "map_id": "FBgn0029800", "name": "lin-52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W542", "map_id": "Q9W542", "name": "mip130", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023509", "map_id": "FBgn0023509", "name": "mip130", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z9E2", "map_id": "A1Z9E2", "name": "mip120", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033846", "map_id": "FBgn0033846", "name": "mip120", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24572", "map_id": "Q24572", "name": "Caf1-55", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263979", "map_id": "FBgn0263979", "name": "Caf1-55", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457963", "map_id": "none", "name": "RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VF04", "map_id": "Q9VF04", "name": "phospho-Rbf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038390", "map_id": "FBgn0038390", "name": "phospho-Rbf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458997", "map_id": "none", "name": "DREAM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458021", "map_id": "none", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458019", "map_id": "none", "name": "HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10459092", "map_id": "none", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10457947", "map_id": "none", "name": "Homologues of RBL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10459090", "map_id": "none", "name": "RBL2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10459011", "map_id": "none", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10459003", "map_id": "none", "name": "MuvB complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10459008", "map_id": "P49657", "name": "mnb", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0259168", "map_id": "FBgn0259168", "name": "mnb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459088", "map_id": "none", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10459086", "map_id": "none", "name": "RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10439374", "map_id": "none", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10439372", "map_id": "Q7JNL9", "name": "dap", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0010316", "map_id": "FBgn0010316", "name": "phospho-dap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10427755", "map_id": "Q7JNL9", "name": "dap", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10439484", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427716", "map_id": "none", "name": "CCNE:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427482", "map_id": "none", "name": "Cyclin E:p-T160-CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P54733", "map_id": "P54733", "name": "CycE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010382", "map_id": "FBgn0010382", "name": "CycE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10431137", "map_id": "none", "name": "CAK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10440842", "map_id": "none", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440840", "map_id": "Q7JNL9", "name": "phospho-dap", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10435622", "map_id": "none", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10427710", "map_id": "none", "name": "CCNE:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10439404", "map_id": "none", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10439395", "map_id": "none", "name": "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7JNL9", "map_id": "Q7JNL9", "name": "phospho-dap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24152", "map_id": "Q24152", "name": "Cks30A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010314", "map_id": "FBgn0010314", "name": "Cks30A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10439399", "map_id": "none", "name": "Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10439401", "map_id": "none", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10439393", "map_id": "none", "name": "CUL1:SKP1:SKP2:CKS1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427484", "map_id": "none", "name": "CCNA:p-T160-CDK2,CCNE:p-T160-CDK2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10439384", "map_id": "none", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10439376", "map_id": "none", "name": "Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10439381", "map_id": "none", "name": "Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10439397", "map_id": "none", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10427729", "map_id": "none", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427721", "map_id": "none", "name": "Cyclin E:p-CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427726", "map_id": "P54350", "name": "Wee1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0011737", "map_id": "FBgn0011737", "name": "Wee1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427712", "map_id": "none", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427704", "map_id": "P23573", "name": "Cdk2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10427706", "map_id": "P54733", "name": "CycE", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10427760", "map_id": "none", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427757", "map_id": "none", "name": "Cyclin E:CDK2:CDKN1A,CDKN1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427744", "map_id": "none", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427741", "map_id": "none", "name": "Homologues of CDC25A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427470", "map_id": "none", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68419", "map_id": "none", "name": "origin of replication", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427294", "map_id": "none", "name": "DNA polymerase epsilon", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VCN1", "map_id": "Q9VCN1", "name": "DNApol-epsilon255", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264326", "map_id": "FBgn0264326", "name": "DNApol-epsilon255", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W256", "map_id": "Q9W256", "name": "Mes4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034726", "map_id": "FBgn0034726", "name": "Mes4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V444", "map_id": "Q9V444", "name": "Chrac-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0043002", "map_id": "FBgn0043002", "name": "Chrac-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRQ7", "map_id": "Q9VRQ7", "name": "DNApol-epsilon58", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035644", "map_id": "FBgn0035644", "name": "DNApol-epsilon58", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10427296", "map_id": "none", "name": "DNA polymerase epsilon:origin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427363", "map_id": "none", "name": "CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O96989", "map_id": "O96989", "name": "Cdc45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026143", "map_id": "FBgn0026143", "name": "Cdc45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGW6", "map_id": "Q9VGW6", "name": "Mcm5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017577", "map_id": "FBgn0017577", "name": "Mcm5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49735", "map_id": "P49735", "name": "Mcm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014861", "map_id": "FBgn0014861", "name": "Mcm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q26454", "map_id": "Q26454", "name": "dpa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015929", "map_id": "FBgn0015929", "name": "dpa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XYU0", "map_id": "Q9XYU0", "name": "Mcm7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020633", "map_id": "FBgn0020633", "name": "Mcm7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XYU1", "map_id": "Q9XYU1", "name": "Mcm3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284442", "map_id": "FBgn0284442", "name": "Mcm3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V461", "map_id": "Q9V461", "name": "Mcm6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025815", "map_id": "FBgn0025815", "name": "Mcm6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24168", "map_id": "Q24168", "name": "Orc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015270", "map_id": "FBgn0015270", "name": "Orc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VF30", "map_id": "Q9VF30", "name": "rec", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003227", "map_id": "FBgn0003227", "name": "rec", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16810", "map_id": "O16810", "name": "Orc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286788", "map_id": "FBgn0286788", "name": "Orc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K2L1", "map_id": "Q7K2L1", "name": "Orc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005654", "map_id": "FBgn0005654", "name": "Orc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24169", "map_id": "Q24169", "name": "Orc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015271", "map_id": "FBgn0015271", "name": "Orc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y1B2", "map_id": "Q9Y1B2", "name": "Orc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023180", "map_id": "FBgn0023180", "name": "Orc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W102", "map_id": "Q9W102", "name": "Orc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023181", "map_id": "FBgn0023181", "name": "Orc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSM9", "map_id": "Q9VSM9", "name": "Cdc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035918", "map_id": "FBgn0035918", "name": "Cdc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIE6", "map_id": "Q9VIE6", "name": "Mcm10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032929", "map_id": "FBgn0032929", "name": "Mcm10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ90", "map_id": "Q9VJ90", "name": "Dmel\\CG5790", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032677", "map_id": "FBgn0032677", "name": "Dmel\\CG5790", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NK54", "map_id": "Q9NK54", "name": "chif", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000307", "map_id": "FBgn0000307", "name": "chif", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427372", "map_id": "none", "name": "CDK and DDK associate with the Mcm10:pre-replicative complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427348", "map_id": "none", "name": "DDK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427336", "map_id": "none", "name": "CDK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427357", "map_id": "none", "name": "MCM10:active pre-replicative complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427359", "map_id": "none", "name": "CDK:DDK:MCM10:active pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427468", "map_id": "none", "name": "Mcm2-7 is phosphorylated by DDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427244", "map_id": "none", "name": "MCM2-7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427465", "map_id": "none", "name": "p-MCM2-7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427370", "map_id": "none", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427327", "map_id": "O96989", "name": "Cdc45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427361", "map_id": "none", "name": "CDK:DDK:MCM10:active pre-replicative complex:CDC45", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427368", "map_id": "none", "name": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427322", "map_id": "none", "name": "RPA1-4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427750", "map_id": "none", "name": "Cdt1 associates with geminin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427746", "map_id": "Q7JX41", "name": "geminin", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0033081", "map_id": "FBgn0033081", "name": "geminin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10427208", "map_id": "Q7JVY2", "name": "dup", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0000996", "map_id": "FBgn0000996", "name": "dup", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10427748", "map_id": "none", "name": "Cdt1:geminin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7JVY2", "map_id": "Q7JVY2", "name": "dup", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JX41", "map_id": "Q7JX41", "name": "geminin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427365", "map_id": "none", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427298", "map_id": "none", "name": "DNA polymerase alpha:primase:DNA polymerase alpha:origin complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427378", "map_id": "none", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427374", "map_id": "none", "name": "MCM10:pre-replicative complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427376", "map_id": "none", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427353", "map_id": "Q9VIE6", "name": "Mcm10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427246", "map_id": "none", "name": "pre-replicative complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493217", "map_id": "none", "name": "Formation of CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487898", "map_id": "Q7KUZ5", "name": "CycD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0010315", "map_id": "FBgn0010315", "name": "CycD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432397", "map_id": "Q7K306", "name": "Cdk4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10487900", "map_id": "none", "name": "CCND1:CDK4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KUZ5", "map_id": "Q7KUZ5", "name": "CycD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493286", "map_id": "none", "name": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10493276", "map_id": "none", "name": "CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10493284", "map_id": "none", "name": "CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493223", "map_id": "none", "name": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493221", "map_id": "none", "name": "CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10459080", "map_id": "none", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10457975", "map_id": "none", "name": "Homologues of p-T401,S672,S1035-RBL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10459075", "map_id": "none", "name": "PP2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10493288", "map_id": "none", "name": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458002", "map_id": "none", "name": "p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10459078", "map_id": "none", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458015", "map_id": "Q24472", "name": "phospho-Rbf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10493274", "map_id": "none", "name": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493251", "map_id": "none", "name": "CDK4/6:CCND:p-Y77-CDKN1A,p-Y88-CDKN1B,(p-Y91-CDKN1C)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10493271", "map_id": "none", "name": "(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2)", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10458005", "map_id": "none", "name": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10457977", "map_id": "none", "name": "E2F4,E2F5:TFDP1,TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10459109", "map_id": "none", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10459102", "map_id": "none", "name": "p-T401,S672,1035-RBL2:SCF(Skp2):Cks1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10459106", "map_id": "none", "name": "Ub-p-T401,S672,1035-RBL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458017", "map_id": "none", "name": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10459104", "map_id": "none", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10439450", "map_id": "none", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426928", "map_id": "Q27368", "name": "E2f1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10439448", "map_id": "none", "name": "CCNA:p-T160-CDK2:E2F1/E2F3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q27368", "map_id": "Q27368", "name": "phospho-E2f1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "phospho-E2f1", "map_id": "phospho-E2f1", "name": "phospho-E2f1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439464", "map_id": "none", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10439461", "map_id": "none", "name": "CCNA:p-T160-CDK2:p-E2F1/p-E2F3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437631", "map_id": "none", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10437595", "map_id": "none", "name": "CCNB1:p-T14,Y15,T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10437575", "map_id": "none", "name": "CCNB1:p-T14,Y15,T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10437726", "map_id": "none", "name": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437719", "map_id": "none", "name": "CCNB1,CCNB2:p-T14,Y15,T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437671", "map_id": "none", "name": "Homologues of CDC25B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10437692", "map_id": "none", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10435511", "map_id": "none", "name": "Homologues of p-S198-CDC25C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437690", "map_id": "none", "name": "Homologues of p-S198-CDC25C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437659", "map_id": "none", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10437657", "map_id": "none", "name": "CCNA:p-T14-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437651", "map_id": "none", "name": "CCNA:p-T14-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437624", "map_id": "none", "name": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437622", "map_id": "none", "name": "CCNB1:p-T14,T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437655", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437653", "map_id": "none", "name": "CCNA:p-T14,T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437684", "map_id": "none", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10437583", "map_id": "none", "name": "phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437601", "map_id": "none", "name": "p-4S-CCNB1:p-T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10489387", "map_id": "none", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_77087", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_77502", "map_id": "CHEBI:16680", "name": "AdoHcy", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10489379", "map_id": "none", "name": "MeL-PP2A", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10489384", "map_id": "M9NF32", "name": "BG:DS09217.4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0028507", "map_id": "FBgn0028507", "name": "BG:DS09217.4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10437715", "map_id": "none", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10437713", "map_id": "none", "name": "CDC25", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437696", "map_id": "none", "name": "CDC25", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437618", "map_id": "none", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437568", "map_id": "P20439", "name": "CycB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10437609", "map_id": "P23572", "name": "Cdk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10437611", "map_id": "none", "name": "CCNB:CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10437682", "map_id": "none", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437679", "map_id": "none", "name": "CRS kinase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10437649", "map_id": "none", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437645", "map_id": "none", "name": "CCNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10437647", "map_id": "none", "name": "CCNA:CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10437616", "map_id": "none", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437570", "map_id": "none", "name": "Cyclin B1:phospho-Cdc2 ( Thr 14)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437613", "map_id": "Q9NI63", "name": "Myt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0040298", "map_id": "FBgn0040298", "name": "Myt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489395", "map_id": "none", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8857797", "map_id": "CHEBI:17790", "name": "methanol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10489392", "map_id": "Q95R98", "name": "Dmel\\CG5068", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0035951", "map_id": "FBgn0035951", "name": "Dmel\\CG5068", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10437705", "map_id": "none", "name": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437701", "map_id": "none", "name": "CCNA:p-T14,Y15,T161-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10437703", "map_id": "none", "name": "CCNA:p-T161-CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437673", "map_id": "none", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10437665", "map_id": "none", "name": "Homologues of CDC25B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437605", "map_id": "none", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10437585", "map_id": "none", "name": "cytoplasmic Cyclin B1:Cdc2 complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437603", "map_id": "none", "name": "nuclear Cyclin B1:Cdc2 complexes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437635", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437591", "map_id": "none", "name": "CCNB1:p-T14-CDK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437699", "map_id": "none", "name": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10435532", "map_id": "none", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10435530", "map_id": "P54350", "name": "phospho-Wee1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10435516", "map_id": "none", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10435996", "map_id": "none", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10435991", "map_id": "Q9NI63", "name": "Myt1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10435994", "map_id": "Q9NI63", "name": "phospho-Myt1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10488880", "map_id": "none", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488823", "map_id": "none", "name": "SCF-FBXL7:AURKA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VF10", "map_id": "Q9VF10", "name": "Fbxl7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038385", "map_id": "FBgn0038385", "name": "Fbxl7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488877", "map_id": "none", "name": "SCF-FBXL7:PolyUb-AURKA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10488882", "map_id": "none", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488821", "map_id": "none", "name": "SKP1:CUL1:RBX1:FBXL7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10488825", "map_id": "none", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438226", "map_id": "Q9VGF9", "name": "aurA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488890", "map_id": "none", "name": "SCF-FBXL18 ubiquitinates FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10456346", "map_id": "Q9VF10", "name": "Fbxl7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10488885", "map_id": "Q9VF10", "name": "Fbxl7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10488887", "map_id": "none", "name": "SKP1:CUL1:RBX1:FBXL18", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VAZ0", "map_id": "Q9VAZ0", "name": "FBXL8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039554", "map_id": "FBgn0039554", "name": "FBXL8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7YZ95", "map_id": "Q7YZ95", "name": "Skp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037236", "map_id": "FBgn0037236", "name": "Skp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488892", "map_id": "none", "name": "Formation of the SCF-FBXL7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442675", "map_id": "Q9W5E1", "name": "Roc1a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438327", "map_id": "O77430", "name": "SkpA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438329", "map_id": "Q24311", "name": "Cul1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488894", "map_id": "none", "name": "Proteasome-mediated degradation of PolyUb-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10469628", "map_id": "none", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469626", "map_id": "Q9VVR2", "name": "bora", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0259791", "map_id": "FBgn0259791", "name": "bora", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467358", "map_id": "Q9VVR2", "name": "phospho-bora", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10467367", "map_id": "none", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467360", "map_id": "none", "name": "p-S252-BORA:p-T210-PLK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VVR2", "map_id": "Q9VVR2", "name": "bora", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467364", "map_id": "Q9VVR2", "name": "phospho-bora", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10467399", "map_id": "none", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467382", "map_id": "P52304", "name": "polo", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10467396", "map_id": "none", "name": "Phosphorylated Myosin Phosphatase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10467380", "map_id": "none", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10427303", "map_id": "none", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427300", "map_id": "none", "name": "RNA primer:origin duplex:DNA polymerase alpha:primase complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427463", "map_id": "none", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_30187", "map_id": "CHEBI:18077", "name": "dTTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_30185", "map_id": "CHEBI:16311", "name": "dCTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29892", "map_id": "CHEBI:16497", "name": "dGTP", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_29604", "map_id": "CHEBI:16284", "name": "dATP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10427595", "map_id": "none", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427217", "map_id": "Q9XYU1", "name": "Mcm3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427593", "map_id": "none", "name": "Mcm4,6,7 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427242", "map_id": "P49735", "name": "Mcm2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427227", "map_id": "Q9VGW6", "name": "Mcm5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10427452", "map_id": "none", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427382", "map_id": "O16810", "name": "phospho-Orc1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427433", "map_id": "O16810", "name": "phospho-Orc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10427458", "map_id": "none", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427454", "map_id": "O16810", "name": "phospho-Orc1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10427408", "map_id": "none", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427384", "map_id": "none", "name": "pre-replicative complex (Orc1-minus)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427456", "map_id": "none", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10427487", "map_id": "none", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426924", "map_id": "Q9VSM9", "name": "Cdc6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427473", "map_id": "Q9VSM9", "name": "phospho-Cdc6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10427591", "map_id": "none", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427495", "map_id": "none", "name": "ubiquitinated Cdc6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10427589", "map_id": "none", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427489", "map_id": "Q9VSM9", "name": "phospho-Cdc6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10427491", "map_id": "none", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10427694", "map_id": "none", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427682", "map_id": "none", "name": "Processive complex:Okazaki fragments:Remaining Flap", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W088", "map_id": "Q9W088", "name": "Pol31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027903", "map_id": "FBgn0027903", "name": "Pol31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54358", "map_id": "P54358", "name": "DNApol-delta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263600", "map_id": "FBgn0263600", "name": "DNApol-delta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10427686", "map_id": "none", "name": "Processive complex:nicked DNA from adjacent Okazaki fragments", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427691", "map_id": "Q7K7A9", "name": "Fen1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0025832", "map_id": "FBgn0025832", "name": "Fen1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427671", "map_id": "none", "name": "RPA binds to the Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427663", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427669", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap:RPA heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427684", "map_id": "none", "name": "Removal of RNA primer and dissociation of RPA and Dna2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427678", "map_id": "none", "name": "Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8IRL9", "map_id": "Q8IRL9", "name": "DNA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030170", "map_id": "FBgn0030170", "name": "DNA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_418075", "map_id": "CHEBI:16695", "name": "UMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_29626", "map_id": "CHEBI:17345", "name": "GMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_418076", "map_id": "CHEBI:17361", "name": "CMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427676", "map_id": "Q8IRL9", "name": "DNA2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10427680", "map_id": "none", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10427702", "map_id": "none", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_68452", "map_id": "none", "name": "Okazaki fragment", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_69172", "map_id": "none", "name": "ligated okazaki fragment", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10427665", "map_id": "none", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427661", "map_id": "none", "name": "Processive complex:Okazaki fragment complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427626", "map_id": "none", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427622", "map_id": "none", "name": "RFC Heteropentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P53034", "map_id": "P53034", "name": "RfC4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260985", "map_id": "FBgn0260985", "name": "RfC4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U9Q1", "map_id": "Q9U9Q1", "name": "RfC38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028700", "map_id": "FBgn0028700", "name": "RfC38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX15", "map_id": "Q9VX15", "name": "Rfc37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030871", "map_id": "FBgn0030871", "name": "Rfc37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35600", "map_id": "P35600", "name": "Gnf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004913", "map_id": "FBgn0004913", "name": "Gnf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKW3", "map_id": "Q9VKW3", "name": "RfC3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032244", "map_id": "FBgn0032244", "name": "RfC3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10427624", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427641", "map_id": "none", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427635", "map_id": "none", "name": "RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427639", "map_id": "none", "name": "RNA primer-DNA primer:origin duplex:PCNA ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427637", "map_id": "none", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10438762", "map_id": "none", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438753", "map_id": "Q9W2V7", "name": "Psf3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0030196", "map_id": "FBgn0030196", "name": "Psf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438758", "map_id": "Q9VBI1", "name": "Sld5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0039403", "map_id": "FBgn0039403", "name": "Sld5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438743", "map_id": "Q9W0I7", "name": "Psf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0035194", "map_id": "FBgn0035194", "name": "Psf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438748", "map_id": "Q9VQY9", "name": "Psf2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0261976", "map_id": "FBgn0261976", "name": "Psf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438760", "map_id": "none", "name": "GINS complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VQY9", "map_id": "Q9VQY9", "name": "Psf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0I7", "map_id": "Q9W0I7", "name": "Psf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBI1", "map_id": "Q9VBI1", "name": "Sld5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2V7", "map_id": "Q9W2V7", "name": "Psf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438063", "map_id": "none", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438061", "map_id": "none", "name": "CCNA:CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10439454", "map_id": "none", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438267", "map_id": "none", "name": "CCNA:CDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10439452", "map_id": "none", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10439446", "map_id": "none", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10439439", "map_id": "none", "name": "Cyclin A:Cdk2:p21/p27 complex", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10439444", "map_id": "none", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10439441", "map_id": "none", "name": "Cyclin A:Cdk2:phospho-p27/p21 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438353", "map_id": "none", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438265", "map_id": "none", "name": "CCNA:p-Y15-CDK2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438384", "map_id": "none", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10438272", "map_id": "none", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438269", "map_id": "none", "name": "Cdc25 A/B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432407", "map_id": "none", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432405", "map_id": "none", "name": "multi-ubiquitinated phospho-(T286) Cyclin D1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10432403", "map_id": "none", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10432386", "map_id": "Q7KUZ5", "name": "phospho-CycD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10432395", "map_id": "Q7KUZ5", "name": "phospho-CycD", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10432401", "map_id": "none", "name": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10432393", "map_id": "none", "name": "phospho(T286)-Cyclin D1:Cdk4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10432399", "map_id": "none", "name": "phospho(T286)-Cyclin D1:Cdk4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10466073", "map_id": "none", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10466069", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Centromere", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_113560", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_2485002", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10466071", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Centromere", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10466031", "map_id": "Q9VS50", "name": "eco", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0035766", "map_id": "FBgn0035766", "name": "eco", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466036", "map_id": "none", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10466018", "map_id": "none", "name": "Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10466026", "map_id": "none", "name": "Ac-Cohesin:PDS5:WAPAL:Chromosomal Arm", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10498336", "map_id": "none", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498332", "map_id": "Q9V3I8", "name": "Ogg1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0027864", "map_id": "FBgn0027864", "name": "Ogg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498334", "map_id": "Q9V3I8", "name": "Ogg1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10497794", "map_id": "none", "name": "NEIL3 cleaves spiroiminodihydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497791", "map_id": "none", "name": "NEIL3:Sp-DNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9PFV8", "map_id": "M9PFV8", "name": "rgn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261258", "map_id": "FBgn0261258", "name": "rgn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9629439", "map_id": "CHEBI:142623", "name": "Sp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10497784", "map_id": "none", "name": "NEIL3:AP-DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433945", "map_id": "none", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433940", "map_id": "none", "name": "OGG1:(8oxoG:Cyt)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V3I8", "map_id": "Q9V3I8", "name": "Ogg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10433942", "map_id": "none", "name": "OGG1:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110242", "map_id": "CHEBI:44605", "name": "8oxoG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10497787", "map_id": "none", "name": "NEIL3 cleaves 5-guanidinohydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497782", "map_id": "none", "name": "NEIL3:Gh-DNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_9629218", "map_id": "CHEBI:142614", "name": "Gh", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433903", "map_id": "none", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433898", "map_id": "none", "name": "NTHL1:Tg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VIH0", "map_id": "Q9VIH0", "name": "NTH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032907", "map_id": "FBgn0032907", "name": "NTH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_110223", "map_id": "CHEBI:29128", "name": "Tg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433900", "map_id": "none", "name": "NTHL1:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433950", "map_id": "none", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433947", "map_id": "none", "name": "OGG1:FapyG-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5636006", "map_id": "CHEBI:29145", "name": "FapyG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433917", "map_id": "none", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433914", "map_id": "none", "name": "NTHL1:DHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_30140", "map_id": "CHEBI:15901", "name": "DHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433883", "map_id": "none", "name": "Cleavage of thymine by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433880", "map_id": "none", "name": "TDG:(T:G)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V4D8", "map_id": "Q9V4D8", "name": "Thd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10433873", "map_id": "none", "name": "TDG:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433931", "map_id": "none", "name": "Cleavage of ethenocytosine by TDG glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433928", "map_id": "none", "name": "TDG:EtCYT-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110233", "map_id": "CHEBI:29147", "name": "EtCYT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433894", "map_id": "none", "name": "Cleavage of uracil by SMUG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433887", "map_id": "none", "name": "SMUG1:Ura-DNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VEM1", "map_id": "Q9VEM1", "name": "Dmel\\CG5285", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038490", "map_id": "FBgn0038490", "name": "Dmel\\CG5285", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10433891", "map_id": "none", "name": "SMUG1:AP-DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433910", "map_id": "none", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433907", "map_id": "none", "name": "NTHL1:Cg-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110225", "map_id": "CHEBI:29127", "name": "Cg", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433876", "map_id": "none", "name": "Cleavage of uracil by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433869", "map_id": "none", "name": "TDG:(Ura:Gua)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433924", "map_id": "none", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433921", "map_id": "none", "name": "NTHL1:FapyA-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5637659", "map_id": "CHEBI:27983", "name": "FapyA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10474548", "map_id": "none", "name": "NEIL2 cleaves 5-OHU from damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474543", "map_id": "none", "name": "NEIL2:5-OHU-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10474545", "map_id": "none", "name": "NEIL2:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110216", "map_id": "CHEBI:29115", "name": "5-OHU", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434063", "map_id": "none", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434046", "map_id": "none", "name": "APEX1:AP-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P27864", "map_id": "P27864", "name": "Rrp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004584", "map_id": "FBgn0004584", "name": "Rrp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434060", "map_id": "none", "name": "APEX1:SSB(AP->5'-dRP)-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434056", "map_id": "none", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434044", "map_id": "P27864", "name": "Rrp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433936", "map_id": "Q9V3I8", "name": "Ogg1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434054", "map_id": "none", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433865", "map_id": "Q9VIH0", "name": "NTH1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434052", "map_id": "none", "name": "Displacement of SMUG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434050", "map_id": "none", "name": "SMUG1:AP-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433860", "map_id": "Q9VEM1", "name": "Dmel\\CG5285", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434048", "map_id": "none", "name": "Displacement of TDG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10474554", "map_id": "none", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474552", "map_id": "none", "name": "APEX1:SSB(5'-ddRP)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434078", "map_id": "none", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_30555", "map_id": "CHEBI:16516", "name": "dNTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10434075", "map_id": "none", "name": "APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7K7A9", "map_id": "Q7K7A9", "name": "Fen1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434071", "map_id": "none", "name": "APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434086", "map_id": "none", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434082", "map_id": "none", "name": "APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10434084", "map_id": "none", "name": "LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W1H4", "map_id": "Q9W1H4", "name": "DNAlig1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474561", "map_id": "none", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474558", "map_id": "none", "name": "LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432365", "map_id": "none", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432356", "map_id": "Q9W252", "name": "rad50", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0034728", "map_id": "FBgn0034728", "name": "rad50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432361", "map_id": "Q9XYZ4", "name": "mre11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0020270", "map_id": "FBgn0020270", "name": "mre11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432363", "map_id": "none", "name": "RAD50:MRE11A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XYZ4", "map_id": "Q9XYZ4", "name": "mre11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W252", "map_id": "Q9W252", "name": "rad50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468909", "map_id": "none", "name": "MRN complex binds DNA double strand breaks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_75165", "map_id": "none", "name": "DNA double-strand break ends", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10432372", "map_id": "none", "name": "MRN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VT40", "map_id": "Q9VT40", "name": "nbs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261530", "map_id": "FBgn0261530", "name": "nbs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468907", "map_id": "none", "name": "DNA DSBs:MRN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476443", "map_id": "none", "name": "NBN binds KPNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476433", "map_id": "P52295", "name": "Pen", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0267727", "map_id": "FBgn0267727", "name": "Pen", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476435", "map_id": "Q9VT40", "name": "nbs", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10476437", "map_id": "none", "name": "NBN:KPNA2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P52295", "map_id": "P52295", "name": "Pen", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476441", "map_id": "none", "name": "KPNA2 translocates NBN to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432370", "map_id": "Q9VT40", "name": "nbs", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10476439", "map_id": "P52295", "name": "Pen", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10432374", "map_id": "none", "name": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10476320", "map_id": "none", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476315", "map_id": "none", "name": "DNA DSBs:MRN:ATM dimer:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q960X4", "map_id": "Q960X4", "name": "Tip60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026080", "map_id": "FBgn0026080", "name": "Tip60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476317", "map_id": "none", "name": "DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476396", "map_id": "none", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476391", "map_id": "none", "name": "p-T68-CHEK2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O61267", "map_id": "O61267", "name": "phospho-lok", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019686", "map_id": "FBgn0019686", "name": "phospho-lok", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10427797", "map_id": "O61267", "name": "phospho-lok", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10476393", "map_id": "none", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476389", "map_id": "O61267", "name": "phospho-lok", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10478112", "map_id": "none", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10478100", "map_id": "none", "name": "DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10476458", "map_id": "none", "name": "DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476764", "map_id": "none", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476754", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_68454", "map_id": "none", "name": "Flap", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10476761", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476728", "map_id": "none", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476721", "map_id": "none", "name": "DNA DSB:MRN:RBBP8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10476725", "map_id": "none", "name": "Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476743", "map_id": "none", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476735", "map_id": "none", "name": "POLQ homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O18475", "map_id": "O18475", "name": "DNApol-theta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002905", "map_id": "FBgn0002905", "name": "DNApol-theta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476741", "map_id": "none", "name": "Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476757", "map_id": "none", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476749", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_427497", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10476752", "map_id": "none", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10476768", "map_id": "none", "name": "MRN recruits LIG3:XRCC1 to MMEJ sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434098", "map_id": "none", "name": "LIG3:XRCC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9Y095", "map_id": "Q9Y095", "name": "XRCC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026751", "map_id": "FBgn0026751", "name": "XRCC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG84", "map_id": "Q9VG84", "name": "DNAlig3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286075", "map_id": "FBgn0286075", "name": "DNAlig3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476766", "map_id": "none", "name": "Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476783", "map_id": "none", "name": "PPP4C:PPP4R2 dephosphorylates RPA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476563", "map_id": "none", "name": "p-RPA heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10476780", "map_id": "none", "name": "PPP4C:PPP4R2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W2U4", "map_id": "Q9W2U4", "name": "PPP4R2r", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030208", "map_id": "FBgn0030208", "name": "PPP4R2r", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76932", "map_id": "O76932", "name": "Pp4-19C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023177", "map_id": "FBgn0023177", "name": "Pp4-19C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476631", "map_id": "none", "name": "MUS81 binds EME1, EME2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476616", "map_id": "A1Z8C0", "name": "mms4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0033549", "map_id": "FBgn0033549", "name": "mms4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476623", "map_id": "Q9V3T1", "name": "mus81", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0040347", "map_id": "FBgn0040347", "name": "mus81", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476629", "map_id": "none", "name": "MUS81:EME1, (MUS81:EME2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V3T1", "map_id": "Q9V3T1", "name": "mus81", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8C0", "map_id": "A1Z8C0", "name": "mms4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476647", "map_id": "none", "name": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476643", "map_id": "none", "name": "SLX1A:SLX4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VN41", "map_id": "Q9VN41", "name": "slx1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037263", "map_id": "FBgn0037263", "name": "slx1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS48", "map_id": "Q9VS48", "name": "mus312", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002909", "map_id": "FBgn0002909", "name": "mus312", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476645", "map_id": "none", "name": "SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476597", "map_id": "none", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476592", "map_id": "Q27297", "name": "spn-A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0003479", "map_id": "FBgn0003479", "name": "spn-A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476595", "map_id": "Q27297", "name": "phospho-spn-A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427785", "map_id": "O61661", "name": "phospho-grp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0261278", "map_id": "FBgn0261278", "name": "phospho-grp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479290", "map_id": "none", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479283", "map_id": "none", "name": "Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_6781829", "map_id": "CHEBI:17972", "name": "ribonucleoside triphosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10479287", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479322", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479302", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q5BI50", "map_id": "Q5BI50", "name": "Cul4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033260", "map_id": "FBgn0033260", "name": "Cul4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XYZ5", "map_id": "Q9XYZ5", "name": "pic", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260962", "map_id": "FBgn0260962", "name": "pic", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479319", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479304", "map_id": "none", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479300", "map_id": "none", "name": "ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V345", "map_id": "Q9V345", "name": "CSN4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027054", "map_id": "FBgn0027054", "name": "CSN4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTH8", "map_id": "Q7KTH8", "name": "CSN8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261437", "map_id": "FBgn0261437", "name": "CSN8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SYG2", "map_id": "Q8SYG2", "name": "CSN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027055", "map_id": "FBgn0027055", "name": "CSN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCY3", "map_id": "Q9VCY3", "name": "CSN6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028837", "map_id": "FBgn0028837", "name": "CSN6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4S8", "map_id": "Q9V4S8", "name": "CSN7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028836", "map_id": "FBgn0028836", "name": "CSN7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94899", "map_id": "Q94899", "name": "alien", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013746", "map_id": "FBgn0013746", "name": "alien", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZ58", "map_id": "Q9XZ58", "name": "CSN5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027053", "map_id": "FBgn0027053", "name": "CSN5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVU5", "map_id": "Q9VVU5", "name": "CSN1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027057", "map_id": "FBgn0027057", "name": "CSN1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479294", "map_id": "none", "name": "Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477930", "map_id": "none", "name": "COP9 signalosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479285", "map_id": "none", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10431174", "map_id": "none", "name": "TFIIH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10429254", "map_id": "none", "name": "RNA Polymerase II holoenzyme complex (unphosphorylated)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_5688114", "map_id": "none", "name": "Distorted dsDNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10479365", "map_id": "none", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479356", "map_id": "none", "name": "Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P20232", "map_id": "P20232", "name": "TfIIS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010422", "map_id": "FBgn0010422", "name": "TfIIS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBY5", "map_id": "Q9VBY5", "name": "Dmel\\CG11839", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039271", "map_id": "FBgn0039271", "name": "Dmel\\CG11839", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P28518", "map_id": "P28518", "name": "Xpac", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004832", "map_id": "FBgn0004832", "name": "Xpac", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYQ8", "map_id": "Q9VYQ8", "name": "Usp7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479362", "map_id": "none", "name": "TC-NER pre-incision complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479390", "map_id": "none", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433815", "map_id": "none", "name": "ERCC1:ERCC4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24087", "map_id": "Q24087", "name": "mei-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002707", "map_id": "FBgn0002707", "name": "mei-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KMG7", "map_id": "Q7KMG7", "name": "Ercc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028434", "map_id": "FBgn0028434", "name": "Ercc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479386", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10479388", "map_id": "none", "name": "TC-NER incision complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479406", "map_id": "none", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479392", "map_id": "none", "name": "TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10434065", "map_id": "none", "name": "POLD,POLE", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10477654", "map_id": "none", "name": "PCNA homotrimer,MonoUb:K164-PCNA homotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10479404", "map_id": "none", "name": "TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10498533", "map_id": "none", "name": "ERCC3-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479373", "map_id": "none", "name": "TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10479384", "map_id": "none", "name": "TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479395", "map_id": "none", "name": "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10479376", "map_id": "none", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10479402", "map_id": "none", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479397", "map_id": "none", "name": "TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10479399", "map_id": "none", "name": "TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479413", "map_id": "none", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479408", "map_id": "none", "name": "TC-NER post-incision complex:dsDNA with transcription bubble", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477658", "map_id": "none", "name": "(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10479410", "map_id": "none", "name": "LIG1,LIG3:XRCC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477876", "map_id": "none", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477873", "map_id": "none", "name": "(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477869", "map_id": "none", "name": "(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479228", "map_id": "none", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479222", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V3W9", "map_id": "Q9V3W9", "name": "Rad23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026777", "map_id": "FBgn0026777", "name": "Rad23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCD5", "map_id": "Q9VCD5", "name": "Dmel\\CG10694", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039147", "map_id": "FBgn0039147", "name": "Dmel\\CG10694", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24595", "map_id": "Q24595", "name": "Xpc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004698", "map_id": "FBgn0004698", "name": "Xpc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479224", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479226", "map_id": "none", "name": "PARP1 or PARP2 PARylates DDB2 and autoPARylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477240", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477880", "map_id": "none", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469914", "map_id": "Q24595", "name": "Xpc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10477229", "map_id": "none", "name": "RAD23", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477878", "map_id": "none", "name": "XPC:RAD23:CETN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479441", "map_id": "none", "name": "UV-DDB ubiquitinates XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477934", "map_id": "none", "name": "XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477936", "map_id": "none", "name": "XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477932", "map_id": "none", "name": "UV-DDB:COP9 Signalosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477169", "map_id": "none", "name": "INO80 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7K012", "map_id": "Q7K012", "name": "Bap55", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025716", "map_id": "FBgn0025716", "name": "Bap55", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y0Z1", "map_id": "Q9Y0Z1", "name": "Dmel\\CG11970", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027503", "map_id": "FBgn0027503", "name": "Dmel\\CG11970", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ST83", "map_id": "Q8ST83", "name": "pho", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002521", "map_id": "FBgn0002521", "name": "pho", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3D4", "map_id": "Q9W3D4", "name": "Dmel\\CG12659", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040929", "map_id": "FBgn0040929", "name": "Dmel\\CG12659", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH07", "map_id": "Q9VH07", "name": "pont", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040078", "map_id": "FBgn0040078", "name": "pont", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6E8", "map_id": "A1Z6E8", "name": "mdcds_12730", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033019", "map_id": "FBgn0033019", "name": "mdcds_12730", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8D5", "map_id": "A1Z8D5", "name": "Dmel\\CG18004", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033566", "map_id": "FBgn0033566", "name": "Dmel\\CG18004", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX09", "map_id": "Q9VX09", "name": "Arp8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030877", "map_id": "FBgn0030877", "name": "Arp8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFH4", "map_id": "Q9VFH4", "name": "l(3)L1231", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086686", "map_id": "FBgn0086686", "name": "l(3)L1231", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEC3", "map_id": "Q9VEC3", "name": "Arp5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038576", "map_id": "FBgn0038576", "name": "Arp5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V604", "map_id": "Q4V604", "name": "CG13381", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052202", "map_id": "FBgn0052202", "name": "CG13381", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDY1", "map_id": "Q9VDY1", "name": "Ino80", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086613", "map_id": "FBgn0086613", "name": "Ino80", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZJ3", "map_id": "Q9VZJ3", "name": "Rcd5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263832", "map_id": "FBgn0263832", "name": "Rcd5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477871", "map_id": "none", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477242", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477865", "map_id": "none", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477858", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477862", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433817", "map_id": "none", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433808", "map_id": "Q7KMG7", "name": "Ercc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433813", "map_id": "Q24087", "name": "mei-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10480324", "map_id": "none", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10480310", "map_id": "none", "name": "SUMO1,2,3:UBE2I", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480319", "map_id": "none", "name": "Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10480321", "map_id": "none", "name": "PIAS1,3", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10477248", "map_id": "none", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477221", "map_id": "P28518", "name": "Xpac", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10477246", "map_id": "none", "name": "Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477856", "map_id": "none", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477849", "map_id": "none", "name": "GG-NER pre-incision complex:Open bubble-dsDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477851", "map_id": "none", "name": "GG-NER incision complex:Open bubble dsDNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477854", "map_id": "none", "name": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477652", "map_id": "none", "name": "GG-NER incision complex:5'-incised damaged DNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477662", "map_id": "none", "name": "DNA polymerases delta, epsilon or kappa bind the GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477660", "map_id": "none", "name": "GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475262", "map_id": "none", "name": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475257", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:USP1:WDR48:Damaged DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q1LZ08", "map_id": "Q1LZ08", "name": "WDR48", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033607", "map_id": "FBgn0033607", "name": "WDR48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I077", "map_id": "Q8I077", "name": "Usp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028476", "map_id": "FBgn0028476", "name": "Usp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475255", "map_id": "none", "name": "USP1:WDR48", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10475259", "map_id": "none", "name": "PCNA:RPA:RFC:Damaged DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10474603", "map_id": "none", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474580", "map_id": "none", "name": "PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10474599", "map_id": "none", "name": "RBX1:CUL4:DDB1:DTL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24371", "map_id": "Q24371", "name": "l(2)dtl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013548", "map_id": "FBgn0013548", "name": "l(2)dtl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474601", "map_id": "none", "name": "RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475271", "map_id": "none", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475266", "map_id": "Q8I077", "name": "Usp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10475268", "map_id": "Q8I077", "name": "Usp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10475253", "map_id": "Q1LZ08", "name": "WDR48", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10474608", "map_id": "none", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474605", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475264", "map_id": "none", "name": "USP1:WDR48 binds monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10475290", "map_id": "none", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475281", "map_id": "none", "name": "POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VNE1", "map_id": "Q9VNE1", "name": "Rev7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037345", "map_id": "FBgn0037345", "name": "Rev7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GSR1", "map_id": "Q9GSR1", "name": "DNApol-zeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002891", "map_id": "FBgn0002891", "name": "DNApol-zeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0P2", "map_id": "Q9W0P2", "name": "Rev1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035150", "map_id": "FBgn0035150", "name": "Rev1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475287", "map_id": "none", "name": "POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475299", "map_id": "none", "name": "POLK and POLZ cooperate in elongation of mispaired primer termini", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475296", "map_id": "none", "name": "POLK:MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433955", "map_id": "Q9W0P2", "name": "Rev1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433993", "map_id": "none", "name": "POLZ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433981", "map_id": "none", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433970", "map_id": "none", "name": "REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433978", "map_id": "none", "name": "REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434039", "map_id": "none", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433986", "map_id": "Q9GSR1", "name": "DNApol-zeta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433991", "map_id": "Q9VNE1", "name": "Rev7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433972", "map_id": "none", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433968", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10474610", "map_id": "none", "name": "REV1 recruits POLZ to (AP:Cyt)-DNA Template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433995", "map_id": "none", "name": "POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434002", "map_id": "none", "name": "POLZ extends translesion synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433999", "map_id": "none", "name": "REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475337", "map_id": "none", "name": "POLZ elongates POLI-incorporated dNMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475325", "map_id": "none", "name": "POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VHV1", "map_id": "Q9VHV1", "name": "DNApol-iota", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037554", "map_id": "FBgn0037554", "name": "DNApol-iota", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475334", "map_id": "none", "name": "POLI:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T-mispaireddNMPs)-DNA Template,(Gamma-HOPdG:C-mispaireddNMPs)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475319", "map_id": "none", "name": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475315", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10475311", "map_id": "none", "name": "POLI:Mg2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10475317", "map_id": "none", "name": "POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475328", "map_id": "none", "name": "POLI incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10474686", "map_id": "none", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474682", "map_id": "none", "name": "PCNA:RPA:RFC:TLS-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10474684", "map_id": "none", "name": "PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10474680", "map_id": "none", "name": "USP43 binds ISG:K164,ISG:K168-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474672", "map_id": "Q9W117", "name": "Usp15-31", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0050421", "map_id": "FBgn0050421", "name": "Usp15-31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474676", "map_id": "none", "name": "ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10474678", "map_id": "none", "name": "USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W117", "map_id": "Q9W117", "name": "Usp15-31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10434030", "map_id": "none", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434013", "map_id": "none", "name": "POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VNX1", "map_id": "Q9VNX1", "name": "DNApol-eta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037141", "map_id": "FBgn0037141", "name": "DNApol-eta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434027", "map_id": "none", "name": "POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475228", "map_id": "none", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475219", "map_id": "none", "name": "NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VXU6", "map_id": "Q9VXU6", "name": "mh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267977", "map_id": "FBgn0267977", "name": "mh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTF9", "map_id": "Q9VTF9", "name": "Ufd1-like", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036136", "map_id": "FBgn0036136", "name": "Ufd1-like", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBP9", "map_id": "Q9VBP9", "name": "Npl4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039348", "map_id": "FBgn0039348", "name": "Npl4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434007", "map_id": "Q9VNX1", "name": "DNApol-eta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10475225", "map_id": "none", "name": "NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475243", "map_id": "none", "name": "RCHY1 monoubiquitinates POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475230", "map_id": "none", "name": "POLH:RCHY1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VMD4", "map_id": "Q9VMD4", "name": "Rchy1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031816", "map_id": "FBgn0031816", "name": "Rchy1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434018", "map_id": "Q9VMD4", "name": "Rchy1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10475240", "map_id": "none", "name": "MonoUb:K682,K686,K694,K709-POLH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475223", "map_id": "none", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434034", "map_id": "none", "name": "POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10475199", "map_id": "Q9VXU6", "name": "mh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10475201", "map_id": "none", "name": "SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434037", "map_id": "none", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10475221", "map_id": "none", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475217", "map_id": "none", "name": "NPLOC4:UFD1L:VCP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434020", "map_id": "none", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434011", "map_id": "none", "name": "MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475232", "map_id": "none", "name": "RCHY1 binds POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10479709", "map_id": "none", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479700", "map_id": "Q8MYL1", "name": "Fancd2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0038827", "map_id": "FBgn0038827", "name": "Fancd2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479705", "map_id": "A1Z7L1", "name": "FANCI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0033354", "map_id": "FBgn0033354", "name": "FANCI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479707", "map_id": "none", "name": "FANCD2:FANCI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A1Z7L1", "map_id": "A1Z7L1", "name": "FANCI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MYL1", "map_id": "Q8MYL1", "name": "Fancd2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449934", "map_id": "none", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_209914", "map_id": "CHEBI:28790", "name": "5HT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449931", "map_id": "P51905", "name": "SerT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0010414", "map_id": "FBgn0010414", "name": "SerT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445846", "map_id": "none", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_380598", "map_id": "CHEBI:50157", "name": "HIALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_380593", "map_id": "CHEBI:27823", "name": "HIAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10429091", "map_id": "none", "name": "ALDH2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VLC5", "map_id": "Q9VLC5", "name": "Aldh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0012036", "map_id": "FBgn0012036", "name": "Aldh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444860", "map_id": "none", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10497879", "map_id": "none", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444352", "map_id": "none", "name": "Homologues of ACHE", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9Y141", "map_id": "Q9Y141", "name": "GH05741", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027584", "map_id": "FBgn0027584", "name": "GH05741", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZA97", "map_id": "A1ZA97", "name": "Jhedup", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034076", "map_id": "FBgn0034076", "name": "Jhedup", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLA3", "map_id": "Q9VLA3", "name": "Dmel\\CG4382", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032132", "map_id": "FBgn0032132", "name": "Dmel\\CG4382", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T016", "map_id": "Q8T016", "name": "Dmel\\CG12869", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033943", "map_id": "FBgn0033943", "name": "Dmel\\CG12869", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9634838", "map_id": "none", "name": "ACHEIs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10444355", "map_id": "none", "name": "ACHE:ACHEIs", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444357", "map_id": "none", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_372533", "map_id": "CHEBI:15355", "name": "AcCho", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_1524044", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10486033", "map_id": "none", "name": "PIAS1 SUMOylates SP3 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467901", "map_id": "none", "name": "Homologues of SP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VPQ5", "map_id": "Q9VPQ5", "name": "cbt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0043364", "map_id": "FBgn0043364", "name": "cbt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2MGN0", "map_id": "Q2MGN0", "name": "Dmel\\CG3065", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034946", "map_id": "FBgn0034946", "name": "Dmel\\CG3065", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24266", "map_id": "Q24266", "name": "btd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000233", "map_id": "FBgn0000233", "name": "btd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PJG1", "map_id": "M9PJG1", "name": "Sp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020378", "map_id": "FBgn0020378", "name": "Sp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486031", "map_id": "none", "name": "Homologues of SUMO2-K551-SP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10470035", "map_id": "none", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470028", "map_id": "P15348", "name": "Top2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0284220", "map_id": "FBgn0284220", "name": "Top2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470033", "map_id": "P15348", "name": "Top2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10470128", "map_id": "none", "name": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10470071", "map_id": "none", "name": "Chromosome passenger complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7JRJ9", "map_id": "Q7JRJ9", "name": "Incenp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260991", "map_id": "FBgn0260991", "name": "Incenp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLD6", "map_id": "Q9VLD6", "name": "borr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032105", "map_id": "FBgn0032105", "name": "borr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLD7", "map_id": "Q9VLD7", "name": "aust", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032104", "map_id": "FBgn0032104", "name": "aust", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470093", "map_id": "none", "name": "SUMO2,3:Chromosome passenger complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10470095", "map_id": "Q7KNM2", "name": "lwr", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469818", "map_id": "A1Z7P5", "name": "Su(var)2-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10470125", "map_id": "none", "name": "RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "Q9VIW3", "map_id": "Q9VIW3", "name": "RanGAP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003346", "map_id": "FBgn0003346", "name": "RanGAP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470191", "map_id": "none", "name": "SUMOylation of NR1I2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467298", "map_id": "none", "name": "SUMO3:UBE2I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10470184", "map_id": "none", "name": "NR1I2:rifampicin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24143", "map_id": "Q24143", "name": "Hr96", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015240", "map_id": "FBgn0015240", "name": "Hr96", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28077", "map_id": "CHEBI:28077", "name": "CHEBI:28077", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470189", "map_id": "none", "name": "SUMO3-NR1I2:rifampicin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10470143", "map_id": "none", "name": "PIAS2,3,4 SUMOylate RORA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10445281", "map_id": "none", "name": "Homologues of RORA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P45447", "map_id": "P45447", "name": "Eip78C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004865", "map_id": "FBgn0004865", "name": "Eip78C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P31396", "map_id": "P31396", "name": "Hr3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000448", "map_id": "FBgn0000448", "name": "Hr3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470138", "map_id": "none", "name": "Homologues of SUMO2-K240-RORA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10470140", "map_id": "A1Z7P5", "name": "Su(var)2-10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469820", "map_id": "none", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10445316", "map_id": "P33244", "name": "ftz-f1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0001078", "map_id": "FBgn0001078", "name": "ftz-f1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469816", "map_id": "P33244", "name": "ftz-f1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10470156", "map_id": "none", "name": "PIAS1 SUMOylates THRB with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10445311", "map_id": "P13055", "name": "Eip75B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10470154", "map_id": "P13055", "name": "Eip75B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10470167", "map_id": "none", "name": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470158", "map_id": "none", "name": "NR1H2:hydroxycholesterol", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P34021", "map_id": "P34021", "name": "EcR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000546", "map_id": "FBgn0000546", "name": "EcR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34310", "map_id": "CHEBI:34310", "name": "CHEBI:34310", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:1301", "map_id": "CHEBI:1301", "name": "CHEBI:1301", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470164", "map_id": "none", "name": "SUMO2,3-NR1H2:hydroxycholesterol", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10469978", "map_id": "M9PHQ2", "name": "HDAC4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0041210", "map_id": "FBgn0041210", "name": "HDAC4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469718", "map_id": "none", "name": "SUMOylation of RARA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10445299", "map_id": "P13055", "name": "Eip75B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10469715", "map_id": "P13055", "name": "Eip75B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10470149", "map_id": "none", "name": "PIAS2-2 SUMOylates THRA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10445309", "map_id": "P13055", "name": "Eip75B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10470147", "map_id": "P13055", "name": "Eip75B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469826", "map_id": "none", "name": "PIAS4 SUMOylates VDR with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10445234", "map_id": "Q24143", "name": "Hr96", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10469823", "map_id": "Q24143", "name": "Hr96", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10470176", "map_id": "none", "name": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470169", "map_id": "none", "name": "NR1H3:hydroxycholesterol", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10470174", "map_id": "none", "name": "SUMO2,3-NR1H3:hydroxysterol", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10470211", "map_id": "none", "name": "PIAS3 SUMOylates RELA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470193", "map_id": "none", "name": "RELA:RELA:DNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10470209", "map_id": "none", "name": "SUMO3-RELA:SUMO3-RELA:DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10469909", "map_id": "none", "name": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10429333", "map_id": "A1ZBW0", "name": "HnRNP-K", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10469907", "map_id": "A1ZBW0", "name": "HnRNP-K", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469904", "map_id": "none", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469898", "map_id": "Q9VM69", "name": "nop5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0026196", "map_id": "FBgn0026196", "name": "nop5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469902", "map_id": "Q9VM69", "name": "nop5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469992", "map_id": "none", "name": "RANBP2 SUMOylates HDAC4 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469989", "map_id": "M9PHQ2", "name": "HDAC4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469973", "map_id": "none", "name": "PIAS1 SUMOylates SATB1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10444232", "map_id": "Q9W268", "name": "dve", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0020307", "map_id": "FBgn0020307", "name": "dve", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469971", "map_id": "Q9W268", "name": "dve", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10486044", "map_id": "none", "name": "PIAS1 SUMOylates L3MBTL2 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486038", "map_id": "Q9VK33", "name": "Sfmbt", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0032475", "map_id": "FBgn0032475", "name": "Sfmbt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486042", "map_id": "Q9VK33", "name": "Sfmbt", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10469986", "map_id": "none", "name": "PIAS1 SUMOylates SATB2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469980", "map_id": "Q9W268", "name": "dve", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10469984", "map_id": "Q9W268", "name": "dve", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10467179", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467152", "map_id": "O97102", "name": "smt3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10467154", "map_id": "O97102", "name": "smt3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10467176", "map_id": "none", "name": "SENP1,2,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VWK5", "map_id": "Q9VWK5", "name": "Ulp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027603", "map_id": "FBgn0027603", "name": "Ulp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQH8", "map_id": "Q8IQH8", "name": "Dmel\\CG32110", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052110", "map_id": "FBgn0052110", "name": "Dmel\\CG32110", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467217", "map_id": "none", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467213", "map_id": "O97102", "name": "smt3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10467215", "map_id": "O97102", "name": "smt3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10493344", "map_id": "none", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10493338", "map_id": "none", "name": "MECOM:PTEN gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8I7Z8", "map_id": "Q8I7Z8", "name": "ham", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0045852", "map_id": "FBgn0045852", "name": "ham", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493336", "map_id": "none", "name": "PRC1.4,PRC2 (EZH2) core", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10493342", "map_id": "none", "name": "MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493329", "map_id": "none", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10493323", "map_id": "none", "name": "NuRD complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O97159", "map_id": "O97159", "name": "Mi-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262519", "map_id": "FBgn0262519", "name": "Mi-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16102", "map_id": "O16102", "name": "Chd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023395", "map_id": "FBgn0023395", "name": "Chd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493319", "map_id": "none", "name": "SALL4:PTEN gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VKH3", "map_id": "Q9VKH3", "name": "salr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000287", "map_id": "FBgn0000287", "name": "salr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P39770", "map_id": "P39770", "name": "salm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261648", "map_id": "FBgn0261648", "name": "salm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493327", "map_id": "none", "name": "SALL4:NuRD:PTEN gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493377", "map_id": "none", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10493368", "map_id": "Q7PL26", "name": "Maf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0267861", "map_id": "FBgn0267861", "name": "phospho-Maf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493366", "map_id": "Q7PL26", "name": "Maf1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10437040", "map_id": "none", "name": "Active mTORC1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q9W437", "map_id": "Q9W437", "name": "raptor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029840", "map_id": "FBgn0029840", "name": "raptor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V8I2", "map_id": "Q9V8I2", "name": "LAMTOR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034350", "map_id": "FBgn0034350", "name": "LAMTOR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96824", "map_id": "O96824", "name": "Dmel\\CG14812", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026090", "map_id": "FBgn0026090", "name": "Dmel\\CG14812", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW73", "map_id": "Q9VW73", "name": "p18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036932", "map_id": "FBgn0036932", "name": "p18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZL6", "map_id": "Q9VZL6", "name": "LAMTOR4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035469", "map_id": "FBgn0035469", "name": "LAMTOR4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJD2", "map_id": "Q9VJD2", "name": "LAMTOR3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032642", "map_id": "FBgn0032642", "name": "LAMTOR3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHJ4", "map_id": "Q9VHJ4", "name": "RagA-B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037647", "map_id": "FBgn0037647", "name": "RagA-B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K519", "map_id": "Q7K519", "name": "RagC-D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033272", "map_id": "FBgn0033272", "name": "RagC-D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493375", "map_id": "none", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493373", "map_id": "Q7PL26", "name": "phospho-Maf1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10467806", "map_id": "none", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450922", "map_id": "O62602", "name": "lic", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467790", "map_id": "Q9VDS9", "name": "Ask1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0014006", "map_id": "FBgn0014006", "name": "Ask1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467802", "map_id": "none", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467792", "map_id": "none", "name": "MAP3K5:TXN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VDS9", "map_id": "Q9VDS9", "name": "Ask1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V429", "map_id": "Q9V429", "name": "Trx-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1250243", "map_id": "CHEBI:26523", "name": "ROS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467796", "map_id": "Q9W002", "name": "msn", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10495401", "map_id": "none", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495397", "map_id": "Q9VL07", "name": "Utx", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0260749", "map_id": "FBgn0260749", "name": "Utx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495399", "map_id": "none", "name": "KDM6B:Fe2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VL07", "map_id": "Q9VL07", "name": "Utx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467889", "map_id": "none", "name": "Formation of PRC2-EZH2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458993", "map_id": "Q24572", "name": "Caf1-55", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10467875", "map_id": "Q9VKD5", "name": "escl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0032391", "map_id": "FBgn0032391", "name": "escl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467880", "map_id": "P42124", "name": "E(z)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0000629", "map_id": "FBgn0000629", "name": "E(z)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467885", "map_id": "Q9NJG9", "name": "Su(z)12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0020887", "map_id": "FBgn0020887", "name": "Su(z)12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467887", "map_id": "none", "name": "PRC2 (EZH2) Core", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9NJG9", "map_id": "Q9NJG9", "name": "Su(z)12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P42124", "map_id": "P42124", "name": "E(z)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKD5", "map_id": "Q9VKD5", "name": "escl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473727", "map_id": "none", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane" }, { "id": "species_10473705", "map_id": "none", "name": "RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "Q9VC31", "map_id": "Q9VC31", "name": "RabX4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051118", "map_id": "FBgn0051118", "name": "RabX4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2S9", "map_id": "Q9W2S9", "name": "Rab9Db", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030221", "map_id": "FBgn0030221", "name": "Rab9Db", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18338", "map_id": "O18338", "name": "Rab8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262518", "map_id": "FBgn0262518", "name": "Rab8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRK9", "map_id": "Q8IRK9", "name": "Rab9D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0067052", "map_id": "FBgn0067052", "name": "Rab9D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZ47", "map_id": "Q9VZ47", "name": "Rab9Fa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052671", "map_id": "FBgn0052671", "name": "Rab9Fa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRK8", "map_id": "Q8IRK8", "name": "Rab9E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052673", "map_id": "FBgn0052673", "name": "Rab9E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQG6", "map_id": "Q9VQG6", "name": "Dmel\\CG15399", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031460", "map_id": "FBgn0031460", "name": "Dmel\\CG15399", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2V3", "map_id": "Q9W2V3", "name": "RabX2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030200", "map_id": "FBgn0030200", "name": "RabX2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IR98", "map_id": "Q8IR98", "name": "Rab9Fb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052670", "map_id": "FBgn0052670", "name": "Rab9Fb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18335", "map_id": "O18335", "name": "Rab11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015790", "map_id": "FBgn0015790", "name": "Rab11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7A6", "map_id": "A1Z7A6", "name": "Asap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050372", "map_id": "FBgn0050372", "name": "Asap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9ND89", "map_id": "M9ND89", "name": "nuf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013718", "map_id": "FBgn0013718", "name": "nuf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2D5", "map_id": "Q9W2D5", "name": "CngB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266346", "map_id": "FBgn0266346", "name": "CngB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24278", "map_id": "Q24278", "name": "CngA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261612", "map_id": "FBgn0261612", "name": "CngA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4P7VAE4", "map_id": "A0A4P7VAE4", "name": "Dmel\\CG42260", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259145", "map_id": "FBgn0259145", "name": "Dmel\\CG42260", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473723", "map_id": "none", "name": "exocyst complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V8K2", "map_id": "Q9V8K2", "name": "Sec6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266671", "map_id": "FBgn0266671", "name": "Sec6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQQ9", "map_id": "Q9VQQ9", "name": "Sec5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266670", "map_id": "FBgn0266670", "name": "Sec5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVG4", "map_id": "Q9VVG4", "name": "Sec3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266669", "map_id": "FBgn0266669", "name": "Sec3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KRZ3", "map_id": "Q7KRZ3", "name": "Exo84", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266668", "map_id": "FBgn0266668", "name": "Exo84", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSJ8", "map_id": "Q9VSJ8", "name": "Exo70", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266667", "map_id": "FBgn0266667", "name": "Exo70", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDE6", "map_id": "Q9VDE6", "name": "Sec15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266674", "map_id": "FBgn0266674", "name": "Sec15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XTM1", "map_id": "Q9XTM1", "name": "Sec10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266673", "map_id": "FBgn0266673", "name": "Sec10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNH6", "map_id": "Q9VNH6", "name": "Sec8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266672", "map_id": "FBgn0266672", "name": "Sec8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473725", "map_id": "none", "name": "exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13949", "compartment_display": "Golgi-associated vesicle membrane", "complex": "true" }, { "id": "reaction_10473635", "map_id": "none", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473633", "map_id": "none", "name": "ARF4:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P40945", "map_id": "P40945", "name": "Arf102F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013749", "map_id": "FBgn0013749", "name": "Arf102F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473517", "map_id": "none", "name": "ARF4:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10444051", "map_id": "A1Z8W8", "name": "garz", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0264560", "map_id": "FBgn0264560", "name": "garz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473683", "map_id": "none", "name": "ASAP1 stimulates GTPase activity of ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10473678", "map_id": "none", "name": "RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10473680", "map_id": "none", "name": "RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10473745", "map_id": "none", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10473743", "map_id": "none", "name": "VxPx-containing ciliary membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "reaction_10433822", "map_id": "none", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500077", "map_id": "none", "name": "(d)GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28862", "map_id": "CHEBI:28862", "name": "CHEBI:28862", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500071", "map_id": "none", "name": "(d)GMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10431187", "map_id": "Q9VTB3", "name": "Dmel\\CG11811", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036099", "map_id": "FBgn0036099", "name": "Dmel\\CG11811", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10452894", "map_id": "none", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_482625", "map_id": "none", "name": "(d)NTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500739", "map_id": "CHEBI:17625", "name": "dUTP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_482627", "map_id": "none", "name": "(d)NDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:28846", "map_id": "CHEBI:28846", "name": "CHEBI:28846", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16174", "map_id": "CHEBI:16174", "name": "CHEBI:16174", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28850", "map_id": "CHEBI:28850", "name": "CHEBI:28850", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:18075", "map_id": "CHEBI:18075", "name": "CHEBI:18075", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_110094", "map_id": "CHEBI:17239", "name": "CDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10452889", "map_id": "none", "name": "nucleoside diphosphate kinase 1A:5B heterohexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P08879", "map_id": "P08879", "name": "awd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000150", "map_id": "FBgn0000150", "name": "awd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10480029", "map_id": "none", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_6788813", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:15918", "map_id": "CHEBI:15918", "name": "CHEBI:15918", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1524067", "map_id": "CHEBI:17361", "name": "cytidine 5'-monophosphate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_6788807", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10480026", "map_id": "Q7JYV7", "name": "Ak6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0033754", "map_id": "FBgn0033754", "name": "Ak6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432346", "map_id": "none", "name": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_499999", "map_id": "none", "name": "dUDP, TDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_499997", "map_id": "none", "name": "dUMP, TMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_109382", "map_id": "CHEBI:17622", "name": "dUMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_109366", "map_id": "CHEBI:17013", "name": "TMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10430985", "map_id": "none", "name": "DTYMK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1ZB29", "map_id": "A1ZB29", "name": "Dmel\\CG5757", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034299", "map_id": "FBgn0034299", "name": "Dmel\\CG5757", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432344", "map_id": "none", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500006", "map_id": "none", "name": "(d)CDP, UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500009", "map_id": "none", "name": "(d)CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10430860", "map_id": "none", "name": "CMPK1, AK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VBI2", "map_id": "Q9VBI2", "name": "Cmpk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028833", "map_id": "FBgn0028833", "name": "Cmpk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10480021", "map_id": "none", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6788802", "map_id": "none", "name": "(d)NMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_6788801", "map_id": "none", "name": "(d)NDPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10480018", "map_id": "Q9VGU6", "name": "Ak3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0042094", "map_id": "FBgn0042094", "name": "Ak3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486254", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6806885", "map_id": "CHEBI:16862", "name": "NDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6806881", "map_id": "CHEBI:17326", "name": "NTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486251", "map_id": "none", "name": "NME1:NME3 heterohexamer, NME2P1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431502", "map_id": "none", "name": "(d)AMP + ATP <=> (d)ADP + ADP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500087", "map_id": "none", "name": "(d)ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10431499", "map_id": "none", "name": "Adenylate Kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IQG9", "map_id": "Q8IQG9", "name": "Ak1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022709", "map_id": "FBgn0022709", "name": "Ak1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453058", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_110614", "map_id": "CHEBI:17677", "name": "CTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453055", "map_id": "none", "name": "CTPS2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VUL1", "map_id": "Q9VUL1", "name": "CTPsyn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266452", "map_id": "FBgn0266452", "name": "CTPsyn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433850", "map_id": "none", "name": "AMP + ATP <=> ADP + ADP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433845", "map_id": "Q9U915", "name": "Adk2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10434170", "map_id": "none", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8866401", "map_id": "CHEBI:57930", "name": "NDP(3-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8866399", "map_id": "CHEBI:73316", "name": "dNDP(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10434167", "map_id": "none", "name": "RNR (M1M2B)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1222611", "map_id": "CHEBI:29034", "name": "Fe3+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "P48592", "map_id": "P48592", "name": "RnrS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011704", "map_id": "FBgn0011704", "name": "RnrS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48591", "map_id": "P48591", "name": "RnrL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011703", "map_id": "FBgn0011703", "name": "RnrL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_110644", "map_id": "CHEBI:16284", "name": "dATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10431033", "map_id": "none", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_500742", "map_id": "CHEBI:17622", "name": "dUMP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10431030", "map_id": "none", "name": "DUT trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V3I1", "map_id": "Q9V3I1", "name": "dUTPase", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250837", "map_id": "FBgn0250837", "name": "dUTPase", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430962", "map_id": "none", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111355", "map_id": "CHEBI:15635", "name": "THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73604", "map_id": "CHEBI:15633", "name": "DHF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430959", "map_id": "none", "name": "TS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O76511", "map_id": "O76511", "name": "Ts", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024920", "map_id": "FBgn0024920", "name": "Ts", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10434161", "map_id": "none", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434158", "map_id": "none", "name": "RNR (M1M2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431023", "map_id": "none", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431020", "map_id": "none", "name": "CTPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10433838", "map_id": "none", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788778", "map_id": "none", "name": "(d)NMPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_6788782", "map_id": "none", "name": "(d)NDPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433833", "map_id": "none", "name": "AK5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "M9PCF9", "map_id": "M9PCF9", "name": "Dmel\\CG9541", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032083", "map_id": "FBgn0032083", "name": "Dmel\\CG9541", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433836", "map_id": "none", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10453032", "map_id": "none", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_482807", "map_id": "none", "name": "(d)NTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_482803", "map_id": "none", "name": "(d)NDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10453027", "map_id": "none", "name": "NME4 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10480797", "map_id": "none", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10480711", "map_id": "none", "name": "21S pre-rRNA:SSU processome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VC94", "map_id": "Q9VC94", "name": "Dmel\\CG5728", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039182", "map_id": "FBgn0039182", "name": "Dmel\\CG5728", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7W5", "map_id": "Q9I7W5", "name": "Sas10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029755", "map_id": "FBgn0029755", "name": "Sas10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIF6", "map_id": "Q9VIF6", "name": "cg9253", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032919", "map_id": "FBgn0032919", "name": "cg9253", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEJ2", "map_id": "Q9VEJ2", "name": "l(3)07882", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010926", "map_id": "FBgn0010926", "name": "l(3)07882", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVK8", "map_id": "Q9VVK8", "name": "DmRH17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036754", "map_id": "FBgn0036754", "name": "DmRH17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IH00", "map_id": "Q8IH00", "name": "Mat89Ba", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261286", "map_id": "FBgn0261286", "name": "Mat89Ba", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMJ1", "map_id": "Q9VMJ1", "name": "Rrp7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031764", "map_id": 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"protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003062", "map_id": "FBgn0003062", "name": "Fib", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MSW9", "map_id": "Q8MSW9", "name": "U3-55K", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053505", "map_id": "FBgn0053505", "name": "U3-55K", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46072", "map_id": "O46072", "name": "kz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001330", "map_id": "FBgn0001330", "name": "kz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W397", "map_id": "Q9W397", "name": "Dmel\\CG7246", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030081", "map_id": "FBgn0030081", "name": "Dmel\\CG7246", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V7P1", "map_id": "Q9V7P1", "name": "wcd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262560", "map_id": "FBgn0262560", "name": "wcd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5U0X8", "map_id": "Q5U0X8", "name": "Dmel\\CG12325", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033557", "map_id": "FBgn0033557", "name": "Dmel\\CG12325", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JQT9", "map_id": "Q7JQT9", "name": "Dmel\\CG1671", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033454", "map_id": "FBgn0033454", "name": "Dmel\\CG1671", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VE98", "map_id": "Q9VE98", "name": "Dmel\\CG8064", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038597", "map_id": "FBgn0038597", "name": "Dmel\\CG8064", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFV8", "map_id": "Q9VFV8", "name": "Dmel\\CG9799", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038146", "map_id": "FBgn0038146", "name": "Dmel\\CG9799", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q07886", "map_id": "Q07886", "name": "Dbp45A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010220", "map_id": "FBgn0010220", "name": "Dbp45A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1G1", "map_id": "Q9W1G1", "name": "Dmel\\CG3735", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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}, { "id": "Q9VW10", "map_id": "Q9VW10", "name": "Dmel\\CG9300", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036886", "map_id": "FBgn0036886", "name": "Dmel\\CG9300", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBY2", "map_id": "Q9VBY2", "name": "Dmel\\CG11920", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039274", "map_id": "FBgn0039274", "name": "Dmel\\CG11920", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JZ53", "map_id": "Q7JZ53", "name": "mRpS4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": 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"map_id": "Q9W4R1", "name": "Dmel\\CG2875", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029672", "map_id": "FBgn0029672", "name": "Dmel\\CG2875", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3C0", "map_id": "Q9W3C0", "name": "UTP11L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030063", "map_id": "FBgn0030063", "name": "UTP11L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVC9", "map_id": "Q9VVC9", "name": "Dmel\\CG7728", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036686", "map_id": "FBgn0036686", "name": "Dmel\\CG7728", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P56175", "map_id": "P56175", "name": "Rtc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020909", "map_id": "FBgn0020909", "name": "Rtc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUN7", "map_id": "Q9VUN7", "name": "Dmel\\CG7275", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036500", "map_id": "FBgn0036500", "name": "Dmel\\CG7275", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PFG1", "map_id": "M9PFG1", "name": "l(3)72Dn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263605", "map_id": "FBgn0263605", "name": "l(3)72Dn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIG1", "map_id": "Q9VIG1", "name": "l(2)05287", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284251", "map_id": "FBgn0284251", "name": "l(2)05287", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7K2", "map_id": "A1Z7K2", "name": "CG2396", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050349", "map_id": "FBgn0050349", "name": "CG2396", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM75", "map_id": "Q9VM75", "name": "l(2)k09022", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086451", "map_id": "FBgn0086451", "name": "l(2)k09022", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4Z9", "map_id": "Q9W4Z9", "name": "Dmel\\CG3071", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023527", "map_id": "FBgn0023527", "name": "Dmel\\CG3071", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3K3", "map_id": "Q9W3K3", "name": "Dmel\\CG2260", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030000", "map_id": "FBgn0030000", "name": "Dmel\\CG2260", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10480770", "map_id": "none", "name": "18SE pre-rRNA:SSU processome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10480794", "map_id": "none", "name": "EXOSC10:C1D:MPHOSPH6:SKIV2L2:Exosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VGZ2", "map_id": "Q9VGZ2", "name": "Rrp46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037815", "map_id": "FBgn0037815", "name": "Rrp46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK19", "map_id": "Q9VK19", "name": "Ski6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032487", "map_id": "FBgn0032487", "name": "Ski6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IPX7", "map_id": "Q8IPX7", "name": "Rrp40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260648", "map_id": "FBgn0260648", "name": "Rrp40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1M9", "map_id": "Q9W1M9", "name": "Rrp4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034879", "map_id": "FBgn0034879", "name": "Rrp4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKJ4", "map_id": "Q9VKJ4", "name": "Csl4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032346", "map_id": "FBgn0032346", "name": "Csl4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T4A9", "map_id": "Q8T4A9", "name": "Rrp45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030789", "map_id": "FBgn0030789", "name": "Rrp45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q29QQ9", "map_id": "Q29QQ9", "name": "Rrp42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034065", "map_id": "FBgn0034065", "name": "Rrp42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW53", "map_id": "Q9VW53", "name": "Mtr3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036916", "map_id": "FBgn0036916", "name": "Mtr3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFF3", "map_id": "Q9VFF3", "name": "Rrp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038269", "map_id": "FBgn0038269", "name": "Rrp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXL4", "map_id": "Q9VXL4", "name": "Rrp47", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030711", "map_id": "FBgn0030711", "name": "Rrp47", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95PE4", "map_id": "Q95PE4", "name": "Mpp6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032921", "map_id": "FBgn0032921", "name": "Mpp6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y134", "map_id": "Q9Y134", "name": "Mtr4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001986", "map_id": "FBgn0001986", "name": "Mtr4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10480430", "map_id": "Q9VFF3", "name": "Rrp6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480782", "map_id": "Q9VGZ2", "name": "Rrp46", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480418", "map_id": "Q9Y134", "name": "Mtr4", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10480745", "map_id": "none", "name": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10480707", "map_id": "none", "name": "30S pre-rRNA:SSU processome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10480713", "map_id": "Q9VBU9", "name": "RpS27", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10430268", "map_id": "P31009", "name": "RpS2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10480715", "map_id": "Q9W229", "name": "RpS24", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480694", "map_id": "Q9VW10", "name": "Dmel\\CG9300", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480689", "map_id": "none", "name": "Homologues of RPS14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10480683", "map_id": "P55935", "name": "RpS9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480681", "map_id": "Q9VA91", "name": "RpS7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480546", "map_id": "none", "name": "UTPA complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10480630", "map_id": "Q9VL75", "name": "Bka", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480717", "map_id": "Q9W237", "name": "RpS16", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480719", "map_id": "Q8T3U2", "name": "RpS23", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480721", "map_id": "Q03334", "name": "RpS13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480723", "map_id": "P55830", "name": "RpS3A", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480725", "map_id": "Q24186", "name": "RpS5a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480727", "map_id": "Q9W334", "name": "RpS28b", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480729", "map_id": "P48149", "name": "RpS15Aa", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480731", "map_id": "Q8MLY8", "name": "RpS8", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480733", "map_id": "Q0E9B6", "name": "RpS11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480738", "map_id": "Q9VXK5", "name": "dSpb1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0030720", "map_id": "FBgn0030720", "name": "dSpb1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10480679", "map_id": "P29327", "name": "RpS6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480743", "map_id": "Q9VC28", "name": "anon-WO0118547.410", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0039233", "map_id": "FBgn0039233", "name": "anon-WO0118547.410", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10480933", "map_id": "none", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10480451", "map_id": "none", "name": "32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8SZY9", "map_id": "Q8SZY9", "name": "CG6316", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052075", "map_id": "FBgn0052075", "name": "CG6316", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3K4", "map_id": "Q9W3K4", "name": "Dmel\\CG1575", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", 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"compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10480395", "map_id": "Q8SZY9", "name": "CG6316", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480400", "map_id": "A1ZA92", "name": "NOL9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10468641", "map_id": "none", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468620", "map_id": "none", "name": "HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P22813", "map_id": "P22813", "name": "phospho-Hsf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001222", "map_id": "FBgn0001222", "name": "phospho-Hsf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468637", "map_id": "none", "name": "HSBP1 hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VK90", "map_id": "Q9VK90", "name": "BcDNA:RE36920", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032429", "map_id": "FBgn0032429", "name": "BcDNA:RE36920", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468639", "map_id": "none", "name": "HSBP1:HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493657", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493653", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10493655", "map_id": "none", "name": "p-Y705-STAT3:p-Y693-STAT4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493663", "map_id": "none", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493632", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_350388", "map_id": "none", "name": "ROK binds to activated RHO1:GTP", "reversible": "false", "notes": "Rho-kinase (ROK) aka Drok binds to activated Rho GTPase (RHO1:GTP) and is itself activated. The conserved Rho-binding site in ROK is the area of interaction.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450801", "map_id": "none", "name": "PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O45030", "map_id": "O45030", "name": "VANG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "VANG", "map_id": "VANG", "name": "VANG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JUF2", "map_id": "Q7JUF2", "name": "DGO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DGO", "map_id": "DGO", "name": "DGO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V5N8", "map_id": "Q9V5N8", "name": "STAN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "STAN", "map_id": "STAN", "name": "STAN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRY0", "map_id": "Q8IRY0", "name": "DAAM", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_350932", "map_id": "Q9U779", "name": "ROK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_450785", "map_id": "none", "name": "PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP:ROK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9U779", "map_id": "Q9U779", "name": "ROK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ROK", "map_id": "ROK", "name": "ROK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_350391", "map_id": "none", "name": "RHO1:GTP binds to activated DAAM", "reversible": "false", "notes": "Activated Rho GTPase (RHO1:GTP) binds to activated Dishevelled Associated Activator of Morphogenesis (DAAM) complexed to Dishevelled (DSH). DAAM is a bridging factor between DSH and RHO1.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_450703", "map_id": "none", "name": "PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_350950", "map_id": "none", "name": "RHO1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_350396", "map_id": "none", "name": "DSH binds to DAAM", "reversible": "false", "notes": "Dishevelled Associated Activator of Morphogenesis (DAAM) is autoinhibited by intramolecular interactions between its GBD and DAD domains. Dishevelled (DSH) binds to the DAD domain of DAAM and disrupts the autoinhibitory interaction, thus activating DAAM.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351034", "map_id": "Q8IRY0", "name": "DAAM", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_450734", "map_id": "none", "name": "PK:VANG:STAN dimer:FZ:DSH:DGO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470444", "map_id": "none", "name": "ATF7IP binds SETDB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470435", "map_id": "Q7KMH9", "name": "wde", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0027499", "map_id": "FBgn0027499", "name": "wde", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470440", "map_id": "Q32KD2", "name": "egg", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0086908", "map_id": "FBgn0086908", "name": "egg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470442", "map_id": "none", "name": "ATF7IP:SETDB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q32KD2", "map_id": "Q32KD2", "name": "egg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KMH9", "map_id": "Q7KMH9", "name": "wde", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495537", "map_id": "none", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10495534", "map_id": "none", "name": "p21 RAS:GTP:RASA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10488125", "map_id": "none", "name": "p-Y1105-ARHGAP35:RASA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495540", "map_id": "none", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10487958", "map_id": "none", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10487955", "map_id": "none", "name": "p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VKB2", "map_id": "Q9VKB2", "name": "Ced-12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032409", "map_id": "FBgn0032409", "name": "Ced-12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488121", "map_id": "none", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488118", "map_id": "none", "name": "p-Y1105-ARHGAP35:RHOA:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10488116", "map_id": "Q9VX32", "name": "phospho-RhoGAPp190", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488123", "map_id": "none", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10488127", "map_id": "none", "name": "ARHGAP35 binds RASA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10487964", "map_id": "none", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454432", "map_id": "Q9VSK2", "name": "phospho-Cbl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10487961", "map_id": "Q9VSK2", "name": "phospho-Cbl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488040", "map_id": "none", "name": "Phosphorylated KHDRBS1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10488022", "map_id": "none", "name": "Homologues of p-Y435,Y440,Y443-KHDRBS1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O44434", "map_id": "O44434", "name": "phospho-qkr58E-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022984", "map_id": "FBgn0022984", "name": "phospho-qkr58E-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W240", "map_id": "Q9W240", "name": "phospho-cg3927", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034739", "map_id": "FBgn0034739", "name": "phospho-cg3927", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W254", "map_id": "Q9W254", "name": "phospho-qkr58E-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022985", "map_id": "FBgn0022985", "name": "phospho-qkr58E-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2D0", "map_id": "Q9W2D0", "name": "phospho-Dmel\\CG4021", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034659", "map_id": "FBgn0034659", "name": "phospho-Dmel\\CG4021", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W224", "map_id": "Q9W224", "name": "phospho-nsr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034740", "map_id": "FBgn0034740", "name": "phospho-nsr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W249", "map_id": "Q9W249", "name": "phospho-cg10384", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034731", "map_id": "FBgn0034731", "name": "phospho-cg10384", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W255", "map_id": "Q9W255", "name": "phospho-qkr58E-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022986", "map_id": "FBgn0022986", "name": "phospho-qkr58E-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488038", "map_id": "none", "name": "Homologues of p-Y435,Y440,Y443-KHDRBS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10469023", "map_id": "none", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469021", "map_id": "none", "name": "Cleaved laminin-332", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10460187", "map_id": "Q9W122", "name": "Mmp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10479128", "map_id": "none", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696409", "map_id": "CHEBI:16752", "name": "5PHL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5693978", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113556", "map_id": "CHEBI:17917", "name": "2AMAS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10479125", "map_id": "none", "name": "PXLP-K278-PHYKPL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VU95", "map_id": "Q9VU95", "name": "PXLP-K278-PHYKPL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036381", "map_id": "FBgn0036381", "name": "PXLP-K278-PHYKPL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466188", "map_id": "none", "name": "DCN (decorin) degradation by MMP2, MMP3, MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10465552", "map_id": "M9MSI4", "name": "DS05899.7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10466183", "map_id": "M9MSI4", "name": "DS05899.7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10466185", "map_id": "M9MSI4", "name": "DS05899.7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10459266", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10459276", "map_id": "none", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10459252", "map_id": "Q9W122", "name": "Mmp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10459247", "map_id": "none", "name": "A2M tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10459274", "map_id": "none", "name": "Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9W122", "map_id": "Q9W122", "name": "Mmp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469689", "map_id": "none", "name": "E-cadherin degradation by ADAM10, ADAM15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469032", "map_id": "none", "name": "CDH1(155-882):Ca2+ dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469040", "map_id": "none", "name": "E-cadherin strand dimer fragment 701-882", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469036", "map_id": "none", "name": "E-cadherin strand dimer fragment 155-700", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469686", "map_id": "none", "name": "ADAM10, ADAM15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q6QU65", "map_id": "Q6QU65", "name": "Meltrin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265140", "map_id": "FBgn0265140", "name": "Meltrin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJW9", "map_id": "Q9VJW9", "name": "phospho-kuz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259984", "map_id": "FBgn0259984", "name": "phospho-kuz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460413", "map_id": "none", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460226", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460411", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460058", "map_id": "none", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460055", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460378", "map_id": "none", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10460376", "map_id": "Q9W122", "name": "Mmp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10459260", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460185", "map_id": "none", "name": "Initial activation of proMMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460060", "map_id": "Q9W122", "name": "Mmp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460064", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460062", "map_id": "Q9W122", "name": "Mmp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460182", "map_id": "none", "name": "Tryptase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VUG2", "map_id": "Q9VUG2", "name": "Dmel\\CG4914", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036436", "map_id": "FBgn0036436", "name": "Dmel\\CG4914", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13582", "map_id": "P13582", "name": "ProEA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ProEA", "map_id": "ProEA", "name": "ProEA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7V4", "map_id": "Q9I7V4", "name": "SP22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042098", "map_id": "FBgn0042098", "name": "SP22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9NDV6", "map_id": "M9NDV6", "name": "Dmel\\CG6865", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036817", "map_id": "FBgn0036817", "name": "Dmel\\CG6865", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUF0", "map_id": "Q9VUF0", "name": "SP40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036427", "map_id": "FBgn0036427", "name": "SP40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MLV8", "map_id": "Q8MLV8", "name": "SPH37", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050287", "map_id": "FBgn0050287", "name": "SPH37", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C5WLM7", "map_id": "C5WLM7", "name": "CG30414-RA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050414", "map_id": "FBgn0050414", "name": "CG30414-RA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR15", "map_id": "Q9VR15", "name": "Dmel\\CG3355", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031619", "map_id": "FBgn0031619", "name": "Dmel\\CG3355", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2C8", "map_id": "Q9W2C8", "name": "tpr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034661", "map_id": "FBgn0034661", "name": "tpr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRK6", "map_id": "Q8IRK6", "name": "Dmel\\CG30288", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050288", "map_id": "FBgn0050288", "name": "Dmel\\CG30288", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZA44", "map_id": "A1ZA44", "name": "Dmel\\CG30083", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050083", "map_id": "FBgn0050083", "name": "Dmel\\CG30083", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK10", "map_id": "Q9VK10", "name": "l(2)k05911", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284244", "map_id": "FBgn0284244", "name": "l(2)k05911", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZS9", "map_id": "Q9VZS9", "name": "CG11531", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053160", "map_id": "FBgn0053160", "name": "CG11531", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRK5", "map_id": "Q8IRK5", "name": "Dmel\\CG30289", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050289", "map_id": "FBgn0050289", "name": "Dmel\\CG30289", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZA38", "map_id": "A1ZA38", "name": "Dmel\\CG30088", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050088", "map_id": "FBgn0050088", "name": "Dmel\\CG30088", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA87", "map_id": "Q9VA87", "name": "c-SP10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039759", "map_id": "FBgn0039759", "name": "c-SP10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXC7", "map_id": "Q9VXC7", "name": "Dmel\\CG9673", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030775", "map_id": "FBgn0030775", "name": "Dmel\\CG9673", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KVM8", "map_id": "Q7KVM8", "name": "Dmel\\CG33226", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0069056", "map_id": "FBgn0069056", "name": "Dmel\\CG33226", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4D6K1E7", "map_id": "A0A4D6K1E7", "name": "Dmel\\CG11836", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039272", "map_id": "FBgn0039272", "name": "Dmel\\CG11836", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA44", "map_id": "Q9VA44", "name": "c-SP11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039798", "map_id": "FBgn0039798", "name": "c-SP11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWD8", "map_id": "Q9VWD8", "name": "SPH158", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031058", "map_id": "FBgn0031058", "name": "SPH158", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KVM3", "map_id": "Q7KVM3", "name": "SP20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034666", "map_id": "FBgn0034666", "name": "SP20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3Z2", "map_id": "Q9V3Z2", "name": "Sp7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037515", "map_id": "FBgn0037515", "name": "Sp7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460409", "map_id": "none", "name": "Autocatalytic activation of bound proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10460396", "map_id": "none", "name": "MMP14:TIMP2:MMP2 intermediate form", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VH14", "map_id": "Q9VH14", "name": "phospho-Timp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025879", "map_id": "FBgn0025879", "name": "phospho-Timp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460050", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460406", "map_id": "none", "name": "MMP14:TIMP:MMP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10460374", "map_id": "none", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460371", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460053", "map_id": "none", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460048", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460437", "map_id": "none", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460380", "map_id": "Q9W122", "name": "Mmp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460435", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460422", "map_id": "Q9W122", "name": "Mmp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460403", "map_id": "none", "name": "Initial activation of proMMP2 by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10460388", "map_id": "none", "name": "MMP14:TIMP2:proMMP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10460392", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460401", "map_id": "O97365", "name": "SPARC", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "FBgn0026562", "map_id": "FBgn0026562", "name": "phospho-SPARC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460433", "map_id": "none", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10459254", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460426", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460369", "map_id": "none", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10460353", "map_id": "none", "name": "proMT-MMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10460367", "map_id": "none", "name": "MT-MMPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10460559", "map_id": "none", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10460557", "map_id": "none", "name": "MT-MMPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10460334", "map_id": "none", "name": "proMMP9 binds TIMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460224", "map_id": "Q9W122", "name": "Mmp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10452419", "map_id": "Q9VH14", "name": "Timp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460332", "map_id": "none", "name": "proMMP9:TIMP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10460460", "map_id": "none", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460439", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460424", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460457", "map_id": "none", "name": "MMP3, CTSK, CTSL2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q95029", "map_id": "Q95029", "name": "Cp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013770", "map_id": "FBgn0013770", "name": "Cp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K0S6", "map_id": "Q7K0S6", "name": "Dmel\\CG6347", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033874", "map_id": "FBgn0033874", "name": "Dmel\\CG6347", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAU4", "map_id": "A1ZAU4", "name": "BEST:GH19547", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034229", "map_id": "FBgn0034229", "name": "BEST:GH19547", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460394", "map_id": "none", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460386", "map_id": "Q9W122", "name": "Mmp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460231", "map_id": "none", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460228", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460390", "map_id": "none", "name": "MMP14:TIMP2 binds proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10460191", "map_id": "none", "name": "MMP14:TIMP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10460420", "map_id": "none", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10460197", "map_id": "Q9W122", "name": "Mmp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10460417", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10459256", "map_id": "Q9W122", "name": "Mmp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10460193", "map_id": "none", "name": "MMP14 (MT1-MMP) binds TIMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10460189", "map_id": "Q9VH14", "name": "Timp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10469030", "map_id": "none", "name": "NID1 degradation by MMP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10465781", "map_id": "A1Z9D7", "name": "arr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10469025", "map_id": "A1Z9D7", "name": "arr", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10469027", "map_id": "A1Z9D7", "name": "arr", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10459264", "map_id": "Q9W122", "name": "Mmp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10466181", "map_id": "none", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10443451", "map_id": "none", "name": "Fibronectin matrix", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A1Z7G6", "map_id": "A1Z7G6", "name": "phospho-AAF59068", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033312", "map_id": "FBgn0033312", "name": "phospho-AAF59068", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRM2", "map_id": "Q8IRM2", "name": "phospho-AAN09619", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030164", "map_id": "FBgn0030164", "name": "phospho-AAN09619", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX04", "map_id": "Q9VX04", "name": "phospho-FBpp0074269", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030880", "map_id": "FBgn0030880", "name": "phospho-FBpp0074269", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KT80", "map_id": "Q7KT80", "name": "phospho-DS00929.7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051832", "map_id": "FBgn0051832", "name": "phospho-DS00929.7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VME7", "map_id": "Q9VME7", "name": "phospho-AAF52372", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031804", "map_id": "FBgn0031804", "name": "phospho-AAF52372", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7Z0B2", "map_id": "B7Z0B2", "name": "phospho-AAF47782", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035452", "map_id": "FBgn0035452", "name": "phospho-AAF47782", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95SM8", "map_id": "Q95SM8", "name": "phospho-CG6676", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050281", "map_id": "FBgn0050281", "name": "phospho-CG6676", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W302", "map_id": "Q9W302", "name": "phospho-AAF46535", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030163", "map_id": "FBgn0030163", "name": "phospho-AAF46535", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10459980", "map_id": "none", "name": "Cleaved fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10469045", "map_id": "none", "name": "DCN (decorin) degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10468964", "map_id": "none", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10468949", "map_id": "none", "name": "Cleaved fibronectin matrix Ala(271)/Val(272)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10468961", "map_id": "none", "name": "Homologues of ADAM8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "X2JE21", "map_id": "X2JE21", "name": "mmd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259110", "map_id": "FBgn0259110", "name": "mmd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469043", "map_id": "none", "name": "E-cadherin degradation by MMP9, KLK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10460002", "map_id": "none", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10459999", "map_id": "none", "name": "MMP1, 3, 7, 12, 13, 19, CTSS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10434812", "map_id": "none", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434771", "map_id": "none", "name": "RNA Pol II (hypophosphorylated):capped pre-mRNA complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W147", "map_id": "Q9W147", "name": "Fcp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035026", "map_id": "FBgn0035026", "name": "Fcp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434653", "map_id": "none", "name": "DSIF complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9TVQ5", "map_id": "Q9TVQ5", "name": "spt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028683", "map_id": "FBgn0028683", "name": "spt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V460", "map_id": "Q9V460", "name": "phospho-Spt5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040273", "map_id": "FBgn0040273", "name": "phospho-Spt5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434773", "map_id": "none", "name": "RNA Pol II (hypophosphorylated) complex bound to DSIF protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434778", "map_id": "none", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434658", "map_id": "Q9W147", "name": "Fcp1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10429250", "map_id": "none", "name": "capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434810", "map_id": "none", "name": "Formation of DSIF:NELF:early elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434646", "map_id": "none", "name": "NELF complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24134", "map_id": "Q24134", "name": "TH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010416", "map_id": "FBgn0010416", "name": "TH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y113", "map_id": "Q9Y113", "name": "NELF-B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027553", "map_id": "FBgn0027553", "name": "NELF-B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86NP2", "map_id": "Q86NP2", "name": "Nelf-A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038872", "map_id": "FBgn0038872", "name": "Nelf-A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P92204", "map_id": "P92204", "name": "Nelf-E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017430", "map_id": "FBgn0017430", "name": "Nelf-E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434775", "map_id": "none", "name": "DSIF:NELF:early elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10446741", "map_id": "none", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446737", "map_id": "none", "name": "CCT/TRiC:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W392", "map_id": "Q9W392", "name": "CCT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030086", "map_id": "FBgn0030086", "name": "CCT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHL2", "map_id": "Q9VHL2", "name": "CCT7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037632", "map_id": "FBgn0037632", "name": "CCT7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXQ5", "map_id": "Q9VXQ5", "name": "CCT6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027329", "map_id": "FBgn0027329", "name": "CCT6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P12613", "map_id": "P12613", "name": "CCT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003676", "map_id": "FBgn0003676", "name": "CCT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KKI0", "map_id": "Q7KKI0", "name": "CCT5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010621", "map_id": "FBgn0010621", "name": "CCT5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K3J0", "map_id": "Q7K3J0", "name": "CCT8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284436", "map_id": "FBgn0284436", "name": "CCT8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK69", "map_id": "Q9VK69", "name": "CCT4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032444", "map_id": "FBgn0032444", "name": "CCT4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48605", "map_id": "P48605", "name": "CCT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015019", "map_id": "FBgn0015019", "name": "CCT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446739", "map_id": "none", "name": "CCT/TRiC:ADP:Sphingosine kinase 1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10487280", "map_id": "none", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487278", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10487272", "map_id": "none", "name": "Unfolded G-protein beta subunit:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10488352", "map_id": "none", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488348", "map_id": "none", "name": "RGS7,RGS9,(RGS6,RGS11)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VXA3", "map_id": "Q9VXA3", "name": "RSG7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024941", "map_id": "FBgn0024941", "name": "RSG7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PHI8", "map_id": "M9PHI8", "name": "CG32543", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259927", "map_id": "FBgn0259927", "name": "CG32543", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488332", "map_id": "none", "name": "GNB5:CCT/TRiC:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W3J1", "map_id": "Q9W3J1", "name": "Gbeta5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030011", "map_id": "FBgn0030011", "name": "Gbeta5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488350", "map_id": "none", "name": "RGS7,RGS9,(RGS6,RGS11):GNB5:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10487330", "map_id": "none", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487328", "map_id": "Q9VUR7", "name": "PDCL", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036519", "map_id": "FBgn0036519", "name": "PDCL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487289", "map_id": "Q9VUR7", "name": "phospho-p-S18,S19,S20,S25-PDCL", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488356", "map_id": "none", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488354", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:Partially folded GNB5:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VUR7", "map_id": "Q9VUR7", "name": "PDCL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488360", "map_id": "none", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488358", "map_id": "none", "name": "GNB5:(RGS7,RGS9,(RGS6,RGS11))", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10487274", "map_id": "none", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434577", "map_id": "none", "name": "G-protein beta subunit", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10488330", "map_id": "none", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488328", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P29829", "map_id": "P29829", "name": "Gbeta76C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004623", "map_id": "FBgn0004623", "name": "Gbeta76C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487334", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:G-protein beta 1-4 subunit", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10487340", "map_id": "none", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434560", "map_id": "none", "name": "G-protein gamma subunit", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10487338", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:G-protein beta 1-4:gamma complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10488364", "map_id": "none", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434215", "map_id": "none", "name": "G-protein alpha (q/11/14/15)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P23625", "map_id": "P23625", "name": "Galphaq", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004435", "map_id": "FBgn0004435", "name": "Galphaq", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQV5", "map_id": "Q8MQV5", "name": "14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050054", "map_id": "FBgn0050054", "name": "14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E9A7", "map_id": "Q0E9A7", "name": "14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488362", "map_id": "none", "name": "G-protein heterotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10487293", "map_id": "none", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487291", "map_id": "none", "name": "p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10487295", "map_id": "none", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10435035", "map_id": "none", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435028", "map_id": "none", "name": "IP3R tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114521", "compartment_display": "platelet dense tubular network membrane", "complex": "true" }, { "id": "reaction_10448282", "map_id": "none", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448278", "map_id": "none", "name": "TRPC3/6/7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10448280", "map_id": "none", "name": "DAG-activated TRPC3/6/7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10448164", "map_id": "none", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440788", "map_id": "none", "name": "PKC-delta/epsilon", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P13678", "map_id": "P13678", "name": "phospho-Pkc98E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003093", "map_id": "FBgn0003093", "name": "phospho-Pkc98E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10448162", "map_id": "none", "name": "Protein kinase C, novel isoforms:DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10448320", "map_id": "none", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76108", "map_id": "CHEBI:29089", "name": "1,2-daG3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448317", "map_id": "none", "name": "Diacylglycerol kinase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7K579", "map_id": "Q7K579", "name": "Dgkepsilon", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020930", "map_id": "FBgn0020930", "name": "Dgkepsilon", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JQ65", "map_id": "A8JQ65", "name": "DGKH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085413", "map_id": "FBgn0085413", "name": "DGKH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09103", "map_id": "Q09103", "name": "rdgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261549", "map_id": "FBgn0261549", "name": "rdgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q01583", "map_id": "Q01583", "name": "Dgk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085390", "map_id": "FBgn0085390", "name": "Dgk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10492391", "map_id": "none", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489794", "map_id": "none", "name": "RUNX1:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24040", "map_id": "Q24040", "name": "Bgb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013753", "map_id": "FBgn0013753", "name": "Bgb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10492389", "map_id": "none", "name": "RUNX1:CBFB:CREBBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10435599", "map_id": "none", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435585", "map_id": "O96827", "name": "eEF1beta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0028737", "map_id": "FBgn0028737", "name": "eEF1beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435590", "map_id": "Q9VL18", "name": "eEF1delta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0032198", "map_id": "FBgn0032198", "name": "eEF1delta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435595", "map_id": "Q9NJH0", "name": "eEF1gamma", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0029176", "map_id": "FBgn0029176", "name": "eEF1gamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435597", "map_id": "none", "name": "eEF1B complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9NJH0", "map_id": "Q9NJH0", "name": "eEF1gamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL18", "map_id": "Q9VL18", "name": "eEF1delta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96827", "map_id": "O96827", "name": "eEF1beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10435616", "map_id": "none", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435612", "map_id": "P13060", "name": "eEF2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0000559", "map_id": "FBgn0000559", "name": "eEF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435614", "map_id": "none", "name": "eEF2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P13060", "map_id": "P13060", "name": "eEF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10435606", "map_id": "none", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435601", "map_id": "none", "name": "eEF1A:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P08736", "map_id": "P08736", "name": "eEF1alpha1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284245", "map_id": "FBgn0284245", "name": "eEF1alpha1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P05303", "map_id": "P05303", "name": "eEF1alpha2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000557", "map_id": "FBgn0000557", "name": "eEF1alpha2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10435603", "map_id": "none", "name": "eEF1B:GDP exchange complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10435580", "map_id": "none", "name": "eEF1A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498785", "map_id": "none", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_1254400", "map_id": "CHEBI:50114", "name": "ESTG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10492512", "map_id": "none", "name": "ESR2:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492514", "map_id": "none", "name": "ESTG:ESR2:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492498", "map_id": "none", "name": "ESR dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492488", "map_id": "none", "name": "ESR:ESTG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492496", "map_id": "none", "name": "ESR multimer:ESTG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492518", "map_id": "none", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492508", "map_id": "none", "name": "ESR1:chaperone complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492510", "map_id": "none", "name": "ESTG:ESR1:chaperone complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497254", "map_id": "none", "name": "27-hydroxysterol binds ESR1, ESR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10445260", "map_id": "Q8WS79", "name": "ERR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_9024328", "map_id": "CHEBI:76591", "name": "27-OH-CHOL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10497252", "map_id": "none", "name": "27-OH-CHOL:ESR1,2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495875", "map_id": "none", "name": "NCOA1 binds ESR1:estrogen:TGFA gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495867", "map_id": "none", "name": "ESR1 dimer:estrogen:TGFA gene promoter", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:142773", "map_id": "CHEBI:142773", "name": "CHEBI:142773", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176575", "map_id": "CHEBI:17263", "name": "E1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176619", "map_id": "CHEBI:16469", "name": "E2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:27974", "map_id": "CHEBI:27974", "name": "CHEBI:27974", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10440440", "map_id": "M9ND53", "name": "tai", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10495873", "map_id": "none", "name": "ESR1 dimer:estrogen:TFGA gene:NCOA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495879", "map_id": "none", "name": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495869", "map_id": "none", "name": "ESR1:estrogen:ERE:NCOA3:TFGA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10458126", "map_id": "M9MS40", "name": "nej", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10495877", "map_id": "none", "name": "ESR1:estrogen:ERE:NCOA3:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496935", "map_id": "none", "name": "HATs and coactivators are recruited to the CTSD gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476674", "map_id": "M9ND53", "name": "tai", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10496924", "map_id": "none", "name": "CTSD gene:ESR1:ESTG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10445380", "map_id": "Q9VP05", "name": "MED1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0037109", "map_id": "FBgn0037109", "name": "MED1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465316", "map_id": "none", "name": "Homologues of SP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10496931", "map_id": "Q9W4J8", "name": "Usf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0029711", "map_id": "FBgn0029711", "name": "Usf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496929", "map_id": "Q9W4J8", "name": "Usf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10496933", "map_id": "none", "name": "CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W4J8", "map_id": "Q9W4J8", "name": "Usf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VP05", "map_id": "Q9VP05", "name": "MED1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496587", "map_id": "none", "name": "ESR1:ESTG and EP300 are recruited to TFF3 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10496583", "map_id": "none", "name": "TFF3 gene:FOXA1:GATA3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P14734", "map_id": "P14734", "name": "fkh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000659", "map_id": "FBgn0000659", "name": "fkh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91623", "map_id": "P91623", "name": "grn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001138", "map_id": "FBgn0001138", "name": "grn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52172", "map_id": "P52172", "name": "srp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003507", "map_id": "FBgn0003507", "name": "srp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKZ0", "map_id": "Q9VKZ0", "name": "GATAd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032223", "map_id": "FBgn0032223", "name": "GATAd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496585", "map_id": "none", "name": "TFF3 gene:FOXA1:GATA3:ESR1:ESTG:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496075", "map_id": "none", "name": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10496071", "map_id": "none", "name": "TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P52654", "map_id": "P52654", "name": "TfIIA-L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011289", "map_id": "FBgn0011289", "name": "TfIIA-L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52656", "map_id": "P52656", "name": "TfIIA-S", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013347", "map_id": "FBgn0013347", "name": "TfIIA-S", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447247", "map_id": "Q9VH48", "name": "Art4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0037770", "map_id": "FBgn0037770", "name": "Art4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496073", "map_id": "none", "name": "CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VH48", "map_id": "Q9VH48", "name": "Art4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496077", "map_id": "none", "name": "TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10431317", "map_id": "none", "name": "TFIIA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10431112", "map_id": "none", "name": "Homologues of TBP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10496069", "map_id": "none", "name": "ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496079", "map_id": "none", "name": "DDX5 binds ESR1:estrogen:TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10496067", "map_id": "none", "name": "ESR1:estrogen:TFF1 gene:FOXA1:GATA3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496081", "map_id": "none", "name": "ESR1 binds to TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495863", "map_id": "none", "name": "ESR1 dimer:estrogen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10496065", "map_id": "none", "name": "TFF1 gene:FOXA1:GATA3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496945", "map_id": "none", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10496941", "map_id": "none", "name": "ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VGW7", "map_id": "Q9VGW7", "name": "Art1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037834", "map_id": "FBgn0037834", "name": "Art1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496937", "map_id": "none", "name": "histone acetyltransferases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VTZ1", "map_id": "Q9VTZ1", "name": "Gcn5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020388", "map_id": "FBgn0020388", "name": "Gcn5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496943", "map_id": "none", "name": "ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496947", "map_id": "none", "name": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467587", "map_id": "Q9VGW7", "name": "Art1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10496939", "map_id": "none", "name": "ESR1:estrogen:TFF1 gene:DDX5:TBP:TFIIA:PRMT1:FOXA1:GATA3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496213", "map_id": "none", "name": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10496205", "map_id": "none", "name": "ESR1:ESTG:P-TEFb", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O96433", "map_id": "O96433", "name": "CycT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025455", "map_id": "FBgn0025455", "name": "CycT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17432", "map_id": "O17432", "name": "Cdk9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019949", "map_id": "FBgn0019949", "name": "Cdk9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496209", "map_id": "none", "name": "MYB gene:hypophosphorylated RNA polymerase II:TFIIF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10496211", "map_id": "none", "name": "MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496951", "map_id": "none", "name": "NCOA1 recruits EP300 to TGFA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10496949", "map_id": "none", "name": "ESR1:estrogen:TFGA gene:NCOA1:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10491863", "map_id": "none", "name": "RUNX1 binds ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491861", "map_id": "none", "name": "RUNX1:CBFB:ESR1:estrogen", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496218", "map_id": "none", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10496215", "map_id": "none", "name": "MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495871", "map_id": "none", "name": "NCOA3 binds ESR1:estrogen:TFGA gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10496898", "map_id": "none", "name": "G-proteins dissociate from plasma-membrane estrogen receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496896", "map_id": "none", "name": "ESTG:ESRs:STRN:heterotrimeric G(i) protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P20353", "map_id": "P20353", "name": "Galphai", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001104", "map_id": "FBgn0001104", "name": "Galphai", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D3DML3", "map_id": "D3DML3", "name": "Cka", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0044323", "map_id": "FBgn0044323", "name": "Cka", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465520", "map_id": "none", "name": "ESRs:STRN:ESTG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10434579", "map_id": "none", "name": "G-protein beta-gamma complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10437767", "map_id": "none", "name": "G-protein alpha (i):GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496900", "map_id": "none", "name": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10445744", "map_id": "none", "name": "Heterotrimeric G-protein Gi (inactive)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496903", "map_id": "none", "name": "ESR-associated SRC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496890", "map_id": "none", "name": "ESRs:STRN:ESTG:MyrG-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10465522", "map_id": "none", "name": "ESRs:STRN:ESTG:MyrG-pY419-SRC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496875", "map_id": "none", "name": "ZDHHC7, ZDHHC21 palmitoylate ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_200993", "map_id": "CHEBI:15525", "name": "PALM-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10496865", "map_id": "none", "name": "ESRs:HSBP1 oligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10471012", "map_id": "none", "name": "HSBP1 oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10496857", "map_id": "Q8WS79", "name": "ERR", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10496872", "map_id": "none", "name": "ZDHHC7, ZDHHC21", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9I7L7", "map_id": "Q9I7L7", "name": "Dmel\\CG18810", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042133", "map_id": "FBgn0042133", "name": "Dmel\\CG18810", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBM6", "map_id": "Q9VBM6", "name": "CG17196-PA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039368", "map_id": "FBgn0039368", "name": "CG17196-PA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W251", "map_id": "Q9W251", "name": "Dmel\\CG10344", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034729", "map_id": "FBgn0034729", "name": "Dmel\\CG10344", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQN9", "map_id": "Q8IQN9", "name": "Dmel\\CG13029", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036670", "map_id": "FBgn0036670", "name": "Dmel\\CG13029", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBM5", "map_id": "Q9VBM5", "name": "CG17195-PA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039369", "map_id": "FBgn0039369", "name": "CG17195-PA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBM8", "map_id": "Q9VBM8", "name": "Dmel\\CG17198", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039366", "map_id": "FBgn0039366", "name": "Dmel\\CG17198", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0IGS7", "map_id": "Q0IGS7", "name": "Dmel\\CG4676", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033815", "map_id": "FBgn0033815", "name": "Dmel\\CG4676", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBM4", "map_id": "Q9VBM4", "name": "Dmel\\CG4956", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039370", "map_id": "FBgn0039370", "name": "Dmel\\CG4956", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBM7", "map_id": "Q9VBM7", "name": "Dmel\\CG17197", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039367", "map_id": "FBgn0039367", "name": "Dmel\\CG17197", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K3T4", "map_id": "Q7K3T4", "name": "anon-WO0118547.93", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034057", "map_id": "FBgn0034057", "name": "anon-WO0118547.93", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497874", "map_id": "none", "name": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10497870", "map_id": "none", "name": "p-Y1161,1165,1166-IGF1R", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10497757", "map_id": "none", "name": "ESTG:Me260-ESR1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10497872", "map_id": "none", "name": "ESTG:ESR1:p-3Y-IGF1R:SHC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496888", "map_id": "none", "name": "Estrogen stimulates dimerization of plasma membrane estrogen receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496878", "map_id": "Q8WS79", "name": "ERR", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10496886", "map_id": "none", "name": "ESTG:Me-PalmS-ESR dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10497818", "map_id": "none", "name": "PRMT1 methylates ESRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5279190", "map_id": "CHEBI:15414", "name": "AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "species_10497809", "map_id": "Q8WS79", "name": "ERR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10497815", "map_id": "Q9VGW7", "name": "Art1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10497851", "map_id": "none", "name": "ESR binds STRN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10465518", "map_id": "D3DML3", "name": "Cka", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10497013", "map_id": "none", "name": "PalmS-ESRs:STRN:ESTG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496892", "map_id": "none", "name": "Membrane estrogen receptors bind SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10441093", "map_id": "none", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10497837", "map_id": "none", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497833", "map_id": "Q7JNL9", "name": "phospho-dap", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10497835", "map_id": "Q7JNL9", "name": "phospho-dap", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10497725", "map_id": "none", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441113", "map_id": "Q95V55", "name": "phospho-foxo", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10497727", "map_id": "none", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497563", "map_id": "Q95V55", "name": "phospho-foxo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10497759", "map_id": "none", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10497042", "map_id": "none", "name": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497000", "map_id": "none", "name": "ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:67237", "map_id": "CHEBI:67237", "name": "CHEBI:67237", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:41633", "map_id": "CHEBI:41633", "name": "CHEBI:41633", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497040", "map_id": "none", "name": "NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10496998", "map_id": "none", "name": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_9024383", "map_id": "none", "name": "NR1H3, NR1H2 ligands", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10496994", "map_id": "none", "name": "ABCA1gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q95RJ9", "map_id": "Q95RJ9", "name": "ebi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263933", "map_id": "FBgn0263933", "name": "ebi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTS4", "map_id": "Q7KTS4", "name": "HDAC3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025825", "map_id": "FBgn0025825", "name": "HDAC3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JQT8", "map_id": "Q7JQT8", "name": "Dmel\\CG17002", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033122", "map_id": "FBgn0033122", "name": "Dmel\\CG17002", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496996", "map_id": "none", "name": "ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands:NCOR:GPS2:TBL1:HDAC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497046", "map_id": "none", "name": "NCOA1 recruits EP300 to the ABCA1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497044", "map_id": "none", "name": "EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497002", "map_id": "none", "name": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10496990", "map_id": "none", "name": "NCOR:GPS2:TBL1:HDAC3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497054", "map_id": "none", "name": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497050", "map_id": "none", "name": "UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10497052", "map_id": "none", "name": "UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10474430", "map_id": "none", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471595", "map_id": "none", "name": "SUMO-K102-CRABP2:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8INK3", "map_id": "Q8INK3", "name": "fabp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037913", "map_id": "FBgn0037913", "name": "fabp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471616", "map_id": "none", "name": "SUMO-K102-CRABP2:atRA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471597", "map_id": "none", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471593", "map_id": "Q8INK3", "name": "fabp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10442349", "map_id": "none", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428865", "map_id": "none", "name": "lipo-PDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VM14", "map_id": "Q9VM14", "name": "muc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283658", "map_id": "FBgn0283658", "name": "muc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVL7", "map_id": "Q9VVL7", "name": "E3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036762", "map_id": "FBgn0036762", "name": "E3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8878387", "map_id": "CHEBI:58937", "name": "ThDP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q7K5K3", "map_id": "Q7K5K3", "name": "Pdhb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039635", "map_id": "FBgn0039635", "name": "Pdhb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4H4", "map_id": "Q9W4H4", "name": "Dmel\\CG7024", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029722", "map_id": "FBgn0029722", "name": "Dmel\\CG7024", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KVX1", "map_id": "Q7KVX1", "name": "Pdha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028325", "map_id": "FBgn0028325", "name": "Pdha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10442333", "map_id": "none", "name": "p-lipo-PDH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10442338", "map_id": "P91622", "name": "Pdk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0017558", "map_id": "FBgn0017558", "name": "Pdk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441275", "map_id": "none", "name": "RXRA:PPARD:atRA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10442347", "map_id": "none", "name": "DCA:PDK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P91622", "map_id": "P91622", "name": "Pdk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441277", "map_id": "none", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_549207", "map_id": "CHEBI:17126", "name": "CAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_201034", "map_id": "CHEBI:17490", "name": "L-PCARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10441263", "map_id": "Q9V3K9", "name": "whd", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "FBgn0261862", "map_id": "FBgn0261862", "name": "whd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_29508", "map_id": "CHEBI:15531", "name": "Mal-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10474428", "map_id": "none", "name": "SUMO-CRABP2 dissociates from atRA:RAR:RXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471618", "map_id": "none", "name": "SUMO-CRABP2:atRA:RAR:RXR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10474426", "map_id": "none", "name": "atRA:RAR:RXR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10471614", "map_id": "Q8INK3", "name": "fabp", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10471620", "map_id": "none", "name": "RAR:RXR binds SUMO-CRABP2:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471612", "map_id": "none", "name": "RAR:RXR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10473631", "map_id": "none", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471971", "map_id": "Q8INK3", "name": "fabp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10471973", "map_id": "none", "name": "SUMO-CRABP1:atRA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10472006", "map_id": "none", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30927", "map_id": "CHEBI:16302", "name": "11cROL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_32737", "map_id": "CHEBI:16066", "name": "11cRAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465841", "map_id": "P91615", "name": "Adhr", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0000056", "map_id": "FBgn0000056", "name": "Adhr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472004", "map_id": "none", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_975599", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_975622", "map_id": "CHEBI:17898", "name": "atRAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10472001", "map_id": "none", "name": "ADH1A,1C,4 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P46415", "map_id": "P46415", "name": "Fdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011768", "map_id": "FBgn0011768", "name": "Fdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472051", "map_id": "none", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472048", "map_id": "none", "name": "RDH11,14,DHRS3,DHRS4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VE80", "map_id": "Q9VE80", "name": "Dmel\\CG7675", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038610", "map_id": "FBgn0038610", "name": "Dmel\\CG7675", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SZ46", "map_id": "Q8SZ46", "name": "naz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286852", "map_id": "FBgn0286852", "name": "naz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3K9", "map_id": "Q9W3K9", "name": "Ldsdh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029994", "map_id": "FBgn0029994", "name": "Ldsdh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR28", "map_id": "Q9VR28", "name": "Dmel\\CG15629", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031630", "map_id": "FBgn0031630", "name": "Dmel\\CG15629", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKB8", "map_id": "Q9VKB8", "name": "firl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032405", "map_id": "FBgn0032405", "name": "firl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIG6", "map_id": "Q9VIG6", "name": "Dmel\\CG9265", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032910", "map_id": "FBgn0032910", "name": "Dmel\\CG9265", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCS2", "map_id": "Q9VCS2", "name": "Dmel\\CG13833", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039040", "map_id": "FBgn0039040", "name": "Dmel\\CG13833", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCR9", "map_id": "Q9VCR9", "name": "Dmel\\CG17121", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039043", "map_id": "FBgn0039043", "name": "Dmel\\CG17121", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRJ4", "map_id": "Q9VRJ4", "name": "Dmel\\CG10672", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035588", "map_id": "FBgn0035588", "name": "Dmel\\CG10672", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473201", "map_id": "none", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10471968", "map_id": "none", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471965", "map_id": "none", "name": "RDH10,16,DHRS9,RDHE2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P91615", "map_id": "P91615", "name": "Adhr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436933", "map_id": "none", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10436925", "map_id": "Q9VW83", "name": "gig", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0005198", "map_id": "FBgn0005198", "name": "phospho-gig", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436930", "map_id": "Q9VW83", "name": "phospho-gig", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10436948", "map_id": "none", "name": "Phosphorylation of complexed TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10436942", "map_id": "none", "name": "TSC1:TSC2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VW83", "map_id": "Q9VW83", "name": "phospho-gig", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCC9", "map_id": "Q9VCC9", "name": "Tsc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026317", "map_id": "FBgn0026317", "name": "Tsc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436946", "map_id": "none", "name": "TSC1:Inhibited TSC2-1-P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10436958", "map_id": "none", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10436954", "map_id": "none", "name": "RHEB:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10436956", "map_id": "none", "name": "RHEB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10445901", "map_id": "none", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441308", "map_id": "none", "name": "p-AMPK heterotrimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VDD2", "map_id": "Q9VDD2", "name": "SNF4Agamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264357", "map_id": "FBgn0264357", "name": "SNF4Agamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7Q8", "map_id": "A1Z7Q8", "name": "alc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260972", "map_id": "FBgn0260972", "name": "alc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18645", "map_id": "O18645", "name": "phospho-AMPKalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023169", "map_id": "FBgn0023169", "name": "phospho-AMPKalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441300", "map_id": "none", "name": "AMPK heterotrimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10445898", "map_id": "none", "name": "Homologues of PPM1A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VBF9", "map_id": "Q9VBF9", "name": "Dmel\\CG6036", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039421", "map_id": "FBgn0039421", "name": "Dmel\\CG6036", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q961C5", "map_id": "Q961C5", "name": "alph", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086361", "map_id": "FBgn0086361", "name": "alph", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450613", "map_id": "none", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437109", "map_id": "none", "name": "mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10445887", "map_id": "none", "name": "p-AMPK heterotrimer:AMP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10445892", "map_id": "none", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10445890", "map_id": "none", "name": "p-AMPK phosphorylates TSC1:TSC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445885", "map_id": "none", "name": "TSC1:p-S1387-TSC2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10445906", "map_id": "none", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445903", "map_id": "none", "name": "mTORC1:Ragulator:Rag:GNP:RHEB:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10474811", "map_id": "none", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437032", "map_id": "none", "name": "RagA,B:GTP:RagC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437004", "map_id": "none", "name": "Ragulator", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10437034", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10475738", "map_id": "none", "name": "AKT1S1 (PRAS40) binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10437061", "map_id": "Q7JXA2", "name": "PRAS40", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0267824", "map_id": "FBgn0267824", "name": "phospho-PRAS40", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437063", "map_id": "none", "name": "mTORC1:RHEB:GTP:AKT1S1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q7JXA2", "map_id": "Q7JXA2", "name": "phospho-PRAS40", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498482", "map_id": "none", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678687", "map_id": "none", "name": "sirolimus", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10437068", "map_id": "P48375", "name": "Fkbp12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0013954", "map_id": "FBgn0013954", "name": "Fkbp12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437070", "map_id": "none", "name": "FKBP1A:sirolimus", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P48375", "map_id": "P48375", "name": "Fkbp12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10437111", "map_id": "none", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10437089", "map_id": "none", "name": "Homologues of RPS6KB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VWQ2", "map_id": "Q9VWQ2", "name": "S6KL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283473", "map_id": "FBgn0283473", "name": "S6KL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94533", "map_id": "Q94533", "name": "phospho-S6k", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283472", "map_id": "FBgn0283472", "name": "phospho-S6k", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437099", "map_id": "none", "name": "Homologues of p-S371,T389-RPS6KB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437059", "map_id": "none", "name": "mTORC1:p-T246-AKT1S1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10437077", "map_id": "none", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437048", "map_id": "none", "name": "eIF4E:4E-BP1-P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437046", "map_id": "Q9XZ56", "name": "phospho-Thor", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10437122", "map_id": "none", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430332", "map_id": "P29327", "name": "RpS6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10437119", "map_id": "P29327", "name": "phospho-RpS6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10437136", "map_id": "none", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430497", "map_id": "none", "name": "Homologues of EIF4G1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437134", "map_id": "none", "name": "Homologues of p-S1108,S1148,S1192-EIF4G1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10437072", "map_id": "none", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10430525", "map_id": "none", "name": "eIF4E:4E-BP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10474809", "map_id": "none", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10437036", "map_id": "none", "name": "Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10436975", "map_id": "none", "name": "mTORC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437038", "map_id": "none", "name": "mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10475736", "map_id": "none", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10475733", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10474807", "map_id": "none", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437030", "map_id": "none", "name": "RRAGC,RRAGD:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437017", "map_id": "none", "name": "RRAGA, RRAGB:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10474805", "map_id": "none", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10436992", "map_id": "Q9VJD2", "name": "LAMTOR3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10436997", "map_id": "Q9VZL6", "name": "LAMTOR4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10436982", "map_id": "Q9VW73", "name": "p18", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10437002", "map_id": "O96824", "name": "Dmel\\CG14812", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10436987", "map_id": "Q9V8I2", "name": "LAMTOR2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "reaction_10494954", "map_id": "none", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428011", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10437042", "map_id": "none", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475729", "map_id": "none", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10437057", "map_id": "none", "name": "mTORC1:RHEB:GTP:p-T246-AKT1S1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10432008", "map_id": "P29310", "name": "14-3-3zeta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10445389", "map_id": "none", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10441842", "map_id": "Q8INB9", "name": "phospho-Akt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10438766", "map_id": "none", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10437824", "map_id": "none", "name": "Large latent complex of TGFB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q9V4E6", "map_id": "Q9V4E6", "name": "mav", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039914", "map_id": "FBgn0039914", "name": "mav", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54631", "map_id": "P54631", "name": "scw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005590", "map_id": "FBgn0005590", "name": "scw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P27091", "map_id": "P27091", "name": "gbb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024234", "map_id": "FBgn0024234", "name": "gbb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437860", "map_id": "none", "name": "Dimeric TGFB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10437884", "map_id": "none", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17941", "compartment_display": "early endosome" }, { "id": "species_10437880", "map_id": "none", "name": "TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2/3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q7K9H6", "map_id": "Q7K9H6", "name": "Sara", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026369", "map_id": "FBgn0026369", "name": "Sara", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7L8", "map_id": "A1Z7L8", "name": "babo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011300", "map_id": "FBgn0011300", "name": "babo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437882", "map_id": "none", "name": "TGFB1:p-TGFBR:ZFYVE9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10437893", "map_id": "none", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10437890", "map_id": "none", "name": "TGFB1:p-TGFBR:ZFYVE9:SMAD2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10437826", "map_id": "none", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10437814", "map_id": "none", "name": "Pre-TGFB1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10437967", "map_id": "none", "name": "SMURF2 ubiquitinates SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437962", "map_id": "none", "name": "SMAD2:SMURF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10437964", "map_id": "none", "name": "Ub-SMAD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465227", "map_id": "none", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10465225", "map_id": "none", "name": "SMURF2 binds SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437886", "map_id": "O96660", "name": "Smox", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465352", "map_id": "none", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465345", "map_id": "none", "name": "Ub-SMAD3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465350", "map_id": "none", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437888", "map_id": "O96660", "name": "Smox", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465343", "map_id": "none", "name": "SMAD3:STUB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465365", "map_id": "none", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465358", "map_id": "Q7YU03", "name": "Dmel\\CG3632", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10465360", "map_id": "none", "name": "p-2S-SMAD2/3:MTMR4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10465348", "map_id": "none", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10465363", "map_id": "none", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10465037", "map_id": "none", "name": "Disassembly of tight junctions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10465035", "map_id": "none", "name": "Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "Q0KHR3", "map_id": "Q0KHR3", "name": "baz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000163", "map_id": "FBgn0000163", "name": "baz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454143", "map_id": "none", "name": "USP9X (FAM) binds to ubiquitinated SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454130", "map_id": "P55824", "name": "faf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0005632", "map_id": "FBgn0005632", "name": "faf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10454139", "map_id": "none", "name": "Ub-SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10454132", "map_id": "none", "name": "Ub-SMAD4:USP9X", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P55824", "map_id": "P55824", "name": "faf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454141", "map_id": "none", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10454137", "map_id": "none", "name": "Ub-SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10465341", "map_id": "none", "name": "PARP1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465327", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4:PARP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10465339", "map_id": "none", "name": "PARP1 ADP-ribosylates SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465336", "map_id": "none", "name": "PAR-SMAD2/3:PAR-SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437976", "map_id": "none", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10454135", "map_id": "none", "name": "USP9X (FAM) deubiquitinates SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10465265", "map_id": "none", "name": "SMURF2 monoubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465258", "map_id": "none", "name": "p-T-2S-SMAD2/3:SMAD4:SMURF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10437940", "map_id": "O62609", "name": "Med", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10465256", "map_id": "Q9V853", "name": "Smurf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10465262", "map_id": "none", "name": "Ub-p-T-2S-SMAD2/3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10465294", "map_id": "none", "name": "Degradation of ubiquitinated SKI/SKIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465292", "map_id": "none", "name": "Ub-SKI/Ub-SKIL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q00G30", "map_id": "Q00G30", "name": "Snoo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085450", "map_id": "FBgn0085450", "name": "Snoo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10442669", "map_id": "none", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10442662", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4:PPM1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10442660", "map_id": "none", "name": "Homologues of PPM1A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10442664", "map_id": "O96660", "name": "Smox", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10465260", "map_id": "none", "name": "SMURF2 binds SMAD3 phosphorylated in the linker region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465235", "map_id": "none", "name": "p-T,2S-SMAD2/3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10465356", "map_id": "none", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10465354", "map_id": "none", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10465254", "map_id": "none", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465250", "map_id": "none", "name": "Ub-p-T-2S-SMAD2/3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10465252", "map_id": "none", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465246", "map_id": "none", "name": "p-T-2S-SMAD2/3:SMAD4:NEDDL4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10465244", "map_id": "Q9VVI3", "name": "Nedd4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10465248", "map_id": "none", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10464907", "map_id": "none", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10464905", "map_id": "none", "name": "p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10465242", "map_id": "none", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465239", "map_id": "none", "name": "CDK8:CCNC/ CDK9:CCNT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P25008", "map_id": "P25008", "name": "CycC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004597", "map_id": "FBgn0004597", "name": "CycC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VT57", "map_id": "Q9VT57", "name": "Cdk8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015618", "map_id": "FBgn0015618", "name": "Cdk8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q961D1", "map_id": "Q961D1", "name": "CycK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025674", "map_id": "FBgn0025674", "name": "CycK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465290", "map_id": "none", "name": "MEN1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465288", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4:MEN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10464521", "map_id": "none", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464315", "map_id": "Q45VV3", "name": "yki", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10464519", "map_id": "none", "name": "WWTR1:p-2S-SMAD2/3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465320", "map_id": "none", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10465318", "map_id": "none", "name": "p-2S-SMAD2/3:SMAD4:SP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471447", "map_id": "none", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10471443", "map_id": "none", "name": "Homologues of ATP1B4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_10471445", "map_id": "none", "name": "ATP1B4:SNW1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10464867", "map_id": "none", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464865", "map_id": "none", "name": "WWTR1:p-2S-SMAD2/3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10441485", "map_id": "none", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441476", "map_id": "P42003", "name": "phospho-Mad", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0011648", "map_id": "FBgn0011648", "name": "Mad", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441483", "map_id": "none", "name": "p-2S-SMAD1/5/8:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P42003", "map_id": "P42003", "name": "Mad", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441565", "map_id": "none", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10441493", "map_id": "none", "name": "p-2S-SMAD1/5/8:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10441563", "map_id": "none", "name": "BMP2 binds to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10441506", "map_id": "none", "name": "BMP2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "P07713", "map_id": "P07713", "name": "dpp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000490", "map_id": "FBgn0000490", "name": "dpp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441524", "map_id": "none", "name": "BMPRII:BMPRI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VMT1", "map_id": "Q9VMT1", "name": "tkv", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003716", "map_id": "FBgn0003716", "name": "tkv", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PE88", "map_id": "M9PE88", "name": "wit", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024179", "map_id": "FBgn0024179", "name": "wit", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441526", "map_id": "none", "name": "BMP:BMPRII:BMPRI", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10441499", "map_id": "none", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10441561", "map_id": "none", "name": "Phospho-R-Smad1/5/8 dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17941", "compartment_display": "early endosome" }, { "id": "species_10441557", "map_id": "none", "name": "BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10441559", "map_id": "none", "name": "BMP:p-BMPR:Endofin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10441497", "map_id": "none", "name": "SKI complexes with the Smad complex, suppressing BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437951", "map_id": "Q00G30", "name": "Snoo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10441495", "map_id": "none", "name": "p-2S-SMAD1/5/8:SMAD4:SKI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10441671", "map_id": "none", "name": "An anchoring protein, Endofin, recruits R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441555", "map_id": "Q7K9H6", "name": "Sara", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10441539", "map_id": "none", "name": "BMP:BMPRII:p-4S-BMPRI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10441544", "map_id": "P42003", "name": "Mad", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441567", "map_id": "none", "name": "BMP:p-BMPR:Endofin:SMAD1/5/8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "reaction_10441958", "map_id": "none", "name": "Formation of a heteromeric BMP receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10441522", "map_id": "none", "name": "BMPRII dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10441515", "map_id": "none", "name": "BMPRI dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10441542", "map_id": "none", "name": "Type II receptor phosphorylates type I receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10441570", "map_id": "none", "name": "Activated type I receptor phosphorylates R-Smad1/5/8 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10441553", "map_id": "none", "name": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10457846", "map_id": "none", "name": "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10457836", "map_id": "none", "name": "Activin A,AB,B:ACVR2A,B:ACVR1B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O61643", "map_id": "O61643", "name": "Actbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024913", "map_id": "FBgn0024913", "name": "Actbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457843", "map_id": "none", "name": "Activin A,AB,B:ACVR2A,B:p-ACVR1B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459937", "map_id": "none", "name": "Phosphorylation of SMAD2/3 by Activin:Activin Receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459934", "map_id": "none", "name": "Activin:ACVR2A,B:p-ACVR1B,C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10493361", "map_id": "none", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10493357", "map_id": "none", "name": "'canonical' WNT target genes:TCF/LEF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10493359", "map_id": "none", "name": "'canonical' WNT target gene:TCF/LEF:TLE tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471580", "map_id": "none", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468226", "map_id": "Q8IMA8", "name": "pan", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10471578", "map_id": "none", "name": "TCF7L2/TCF7L1:CTBPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10470019", "map_id": "none", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468236", "map_id": "P16371", "name": "gro", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10440586", "map_id": "none", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440579", "map_id": "none", "name": "p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464922", "map_id": "none", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464912", "map_id": "none", "name": "RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10464916", "map_id": "none", "name": "ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440607", "map_id": "none", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440594", "map_id": "none", "name": "p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10440570", "map_id": "none", "name": "p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440604", "map_id": "none", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440601", "map_id": "none", "name": "p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10440590", "map_id": "none", "name": "p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440616", "map_id": "none", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440611", "map_id": "none", "name": "CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440597", "map_id": "none", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10440584", "map_id": "none", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10464920", "map_id": "none", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464918", "map_id": "none", "name": "p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10471110", "map_id": "none", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441755", "map_id": "none", "name": "AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10440560", "map_id": "none", "name": "p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440613", "map_id": "none", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10464914", "map_id": "none", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10469710", "map_id": "none", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469702", "map_id": "none", "name": "CAMK2:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10469697", "map_id": "none", "name": "p-T286 CAMK2:CaM", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10469834", "map_id": "none", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469828", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A8JUV3", "map_id": "A8JUV3", "name": "phospho-NFAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030505", "map_id": "FBgn0030505", "name": "phospho-NFAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXF1", "map_id": "Q9VXF1", "name": "CanA-14F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267912", "map_id": "FBgn0267912", "name": "CanA-14F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27889", "map_id": "Q27889", "name": "Pp2B-14D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011826", "map_id": "FBgn0011826", "name": "Pp2B-14D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48456", "map_id": "P48456", "name": "CanA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010015", "map_id": "FBgn0010015", "name": "CanA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24214", "map_id": "Q24214", "name": "CanB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015614", "map_id": "FBgn0015614", "name": "CanB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469832", "map_id": "none", "name": "NFATC1:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10469706", "map_id": "none", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449351", "map_id": "none", "name": "CaMKII dodecamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10469704", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469736", "map_id": "none", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469730", "map_id": "none", "name": "pT298-NLK dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A4D6K823", "map_id": "A0A4D6K823", "name": "phospho-nmo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011817", "map_id": "FBgn0011817", "name": "phospho-nmo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469734", "map_id": "none", "name": "pT298-NLK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10469751", "map_id": "none", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469738", "map_id": "none", "name": "TCF/LEF:CTNNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10469748", "map_id": "none", "name": "p-TCF/LEF:CTNNB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10469558", "map_id": "none", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469553", "map_id": "none", "name": "WNT5A/11:FZD:G-protein (alpha o/t2) active", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P16378", "map_id": "P16378", "name": "Galphao", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001122", "map_id": "FBgn0001122", "name": "Galphao", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NBW1", "map_id": "Q9NBW1", "name": "fz4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027342", "map_id": "FBgn0027342", "name": "fz4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O77438", "map_id": "O77438", "name": "fz3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027343", "map_id": "FBgn0027343", "name": "fz3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469538", "map_id": "none", "name": "WNT5A/11:FZD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469543", "map_id": "P16378", "name": "Galphao", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10446854", "map_id": "none", "name": "Gbeta:gamma activation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434175", "map_id": "P25455", "name": "Plc21C", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10469830", "map_id": "none", "name": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464038", "map_id": "A8JUV3", "name": "phospho-NFAT", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10464071", "map_id": "none", "name": "Calcineurin:Calmodulin (CaN:CaM)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10469556", "map_id": "none", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469549", "map_id": "none", "name": "WNT5A/11:FZD:G-protein (alpha o/t2) inactive", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466948", "map_id": "none", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464021", "map_id": "none", "name": "Calcineurin (CaN)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10469700", "map_id": "none", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469695", "map_id": "none", "name": "p-T286,T305,T306-CAMK2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10446865", "map_id": "none", "name": "PLC beta-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10469087", "map_id": "none", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469083", "map_id": "none", "name": "RAC:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10469085", "map_id": "none", "name": "pp-DVL:RAC:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469101", "map_id": "none", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10441768", "map_id": "P51140", "name": "phospho-dsh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469097", "map_id": "none", "name": "WNT:FZD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VFX1", "map_id": "Q9VFX1", "name": "wntD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038134", "map_id": "FBgn0038134", "name": "wntD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P40589", "map_id": "P40589", "name": "Wnt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010453", "map_id": "FBgn0010453", "name": "Wnt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10469099", "map_id": "none", "name": "WNT:FZD:pDVL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470350", "map_id": "none", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10470343", "map_id": "none", "name": "WNT5A:FZD4:DVL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10470345", "map_id": "none", "name": "WNT5A:FZD4:p-DVL2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10470347", "map_id": "none", "name": "Activated Protein kinase C (alpha, beta, gamma isoforms)", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10470362", "map_id": "none", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10441761", "map_id": "P51140", "name": "dsh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10470339", "map_id": "none", "name": "N4GlycoAsn-PalmS-WNT5A:FZD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470360", "map_id": "none", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10470354", "map_id": "none", "name": "clathrin:AP-2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447483", "map_id": "none", "name": "Homologues of ARRB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W2V2", "map_id": "Q9W2V2", "name": "CG15303", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052683", "map_id": "FBgn0052683", "name": "CG15303", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V393", "map_id": "Q9V393", "name": "krz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "krz", "map_id": "krz", "name": "krz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P19107", "map_id": "P19107", "name": "Arr2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000121", "map_id": "FBgn0000121", "name": "Arr2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P15372", "map_id": "P15372", "name": "Arr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000120", "map_id": "FBgn0000120", "name": "Arr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470358", "map_id": "none", "name": "WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470341", "map_id": "none", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469528", "map_id": "none", "name": "Homologues of FZD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470402", "map_id": "none", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle" }, { "id": "species_10470400", "map_id": "none", "name": "WNT5A:FZD4:p-DVL2:AP-2:clathrin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10470415", "map_id": "none", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10470411", "map_id": "none", "name": "FZD2/FZD5/ROR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q24488", "map_id": "Q24488", "name": "Ror", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010407", "map_id": "FBgn0010407", "name": "Ror", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470413", "map_id": "none", "name": "WNT5A:FZDs/ROR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10470429", "map_id": "none", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle" }, { "id": "species_10470427", "map_id": "none", "name": "WNT5A:FZDs/ROR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10468030", "map_id": "none", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10468016", "map_id": "none", "name": "palmitoleyl-N-glycosylated WNTs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "P28465", "map_id": "P28465", "name": "Wnt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004360", "map_id": "FBgn0004360", "name": "Wnt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM26", "map_id": "Q9VM26", "name": "Wnt6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031902", "map_id": "FBgn0031902", "name": "Wnt6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467932", "map_id": "Q95ST2", "name": "wls", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0036141", "map_id": "FBgn0036141", "name": "wls", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468028", "map_id": "none", "name": "WLS:WNT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q95ST2", "map_id": "Q95ST2", "name": "wls", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468026", "map_id": "none", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10467923", "map_id": "Q95ST2", "name": "wls", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "species_10467928", "map_id": "Q9VG51", "name": "Snx3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0038065", "map_id": "FBgn0038065", "name": "Snx3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467918", "map_id": "none", "name": "VPS35:VPS29:VPS26", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W277", "map_id": "Q9W277", "name": "Vps35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034708", "map_id": "FBgn0034708", "name": "Vps35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPX5", "map_id": "Q9VPX5", "name": "Vps29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031310", "map_id": "FBgn0031310", "name": "Vps29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W552", "map_id": "Q9W552", "name": "Vps26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014411", "map_id": "FBgn0014411", "name": "Vps26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467930", "map_id": "none", "name": "WLS:retromer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q9VG51", "map_id": "Q9VG51", "name": "Snx3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468088", "map_id": "none", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10467934", "map_id": "none", "name": "WLS:retromer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10468023", "map_id": "none", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10467992", "map_id": "none", "name": "palmitoleyl-N-glycosylated WNTs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10468021", "map_id": "Q9VXY9", "name": "opm", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0264389", "map_id": "FBgn0264389", "name": "opm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468086", "map_id": "none", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10468032", "map_id": "Q95ST2", "name": "wls", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10468084", "map_id": "none", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10468058", "map_id": "none", "name": "WLS:WNT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10468898", "map_id": "none", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10468866", "map_id": "none", "name": "WLS:WNT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828050", "compartment_display": "multivesicular body, internal vesicle", "complex": "true" }, { "id": "reaction_10468082", "map_id": "none", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10468080", "map_id": "none", "name": "WNTs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VM25", "map_id": "Q9VM25", "name": "Wnt10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031903", "map_id": "FBgn0031903", "name": "Wnt10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468896", "map_id": "none", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_383505", "compartment_display": "extracellular exosome" }, { "id": "species_10468894", "map_id": "none", "name": "WLS:WNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_383505", "compartment_display": "extracellular exosome", "complex": "true" }, { "id": "reaction_10467936", "map_id": "none", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10444271", "map_id": "none", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444262", "map_id": "none", "name": "RAP1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444267", "map_id": "Q9VWB7", "name": "pico", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0261811", "map_id": "FBgn0261811", "name": "pico", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444269", "map_id": "none", "name": "Rap1-GTP:PIP2:RIAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VWB7", "map_id": "Q9VWB7", "name": "pico", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449918", "map_id": "none", "name": "SHC1 dissociates from integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449914", "map_id": "none", "name": "Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P12080", "map_id": "P12080", "name": "if", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001250", "map_id": "FBgn0001250", "name": "if", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444292", "map_id": "none", "name": "Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449916", "map_id": "none", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449253", "map_id": "none", "name": "Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10455337", "map_id": "none", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444300", "map_id": "none", "name": "RAP1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446030", "map_id": "A1Z6P8", "name": "Epac", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0085421", "map_id": "FBgn0085421", "name": "Epac", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444296", "map_id": "none", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444278", "map_id": "none", "name": "Talin:RIAM complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449255", "map_id": "none", "name": "Activated integrin alphaIIb beta3 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10444294", "map_id": "none", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444290", "map_id": "none", "name": "Integrin alphaIIb beta3:p-Y530-SRC:CSK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10464527", "map_id": "none", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458548", "map_id": "Q45VV3", "name": "yki", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10464525", "map_id": "none", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464523", "map_id": "Q45VV3", "name": "yki", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10464317", "map_id": "none", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464309", "map_id": "Q45VV3", "name": "phospho-yki", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10464286", "map_id": "none", "name": "p-LATS2:p-MOB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464300", "map_id": "none", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464261", "map_id": "Q9VA38", "name": "wts", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10464269", "map_id": "Q95RA8", "name": "phospho-mats", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10464271", "map_id": "none", "name": "LATS:p-MOB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464298", "map_id": "none", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464295", "map_id": "Q45VV3", "name": "phospho-yki", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10464281", "map_id": "none", "name": "p-LATS:p-MOB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464313", "map_id": "none", "name": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432016", "map_id": "none", "name": "YWHAE dimer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10464311", "map_id": "none", "name": "p-WWTR1:YWHAE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464568", "map_id": "none", "name": "KIBRA (WWC1) binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464564", "map_id": "Q9VFG8", "name": "kibra", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0262127", "map_id": "FBgn0262127", "name": "kibra", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10464566", "map_id": "none", "name": "KIBRA:LATS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VFG8", "map_id": "Q9VFG8", "name": "kibra", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464693", "map_id": "none", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10464773", "map_id": "none", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464771", "map_id": "none", "name": "p-WWTR1:DVL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464306", "map_id": "none", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432010", "map_id": "none", "name": "YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10464284", "map_id": "Q45VV3", "name": "phospho-yki", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10464304", "map_id": "none", "name": "p-YAP1:YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464289", "map_id": "none", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10440828", "map_id": "none", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440825", "map_id": "Q9VW83", "name": "phospho-gig", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441258", "map_id": "none", "name": "AKT phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441256", "map_id": "Q7JXA2", "name": "phospho-PRAS40", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10493525", "map_id": "none", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10456731", "map_id": "Q9VP20", "name": "Mkrn1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0029152", "map_id": "FBgn0029152", "name": "Mkrn1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493523", "map_id": "Q9VP20", "name": "phospho-Mkrn1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440837", "map_id": "none", "name": "AKT phosphorylates IKKalpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440832", "map_id": "Q9VEZ5", "name": "IKKbeta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440835", "map_id": "Q9VEZ5", "name": "phospho-IKKbeta", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440852", "map_id": "none", "name": "AKT phosphorylates caspase-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434854", "map_id": "none", "name": "Homologues of CASP9(1-416)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10440850", "map_id": "none", "name": "Homologues of p-S196-CASP9(1-416)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465457", "map_id": "none", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465455", "map_id": "none", "name": "PDPK1:PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10441143", "map_id": "none", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10440877", "map_id": "Q9V3Z1", "name": "trbl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10441141", "map_id": "none", "name": "PHLPP dephosphorylates S473 in AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441125", "map_id": "Q8INB9", "name": "phospho-Akt1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441138", "map_id": "none", "name": "PHLPP (Mn2+ cofactor)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q0E8W8", "map_id": "Q0E8W8", "name": "CT11751", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035008", "map_id": "FBgn0035008", "name": "CT11751", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489428", "map_id": "none", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440527", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10489416", "map_id": "none", "name": "p-Y307-PP2A", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10489425", "map_id": "none", "name": "Activated SRC,LCK,EGFR,INSR", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10465529", "map_id": "none", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465526", "map_id": "none", "name": "Activator:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VFI0", "map_id": "Q9VFI0", "name": "phospho-stumps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020299", "map_id": "FBgn0020299", "name": "phospho-stumps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487135", "map_id": "none", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487126", "map_id": "none", "name": "PP2A-B56-beta,gamma", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VXB7", "map_id": "Q9VXB7", "name": "Dmel\\CG32568", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052568", "map_id": "FBgn0052568", "name": "Dmel\\CG32568", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493536", "map_id": "none", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493530", "map_id": "Q7KMQ6", "name": "phospho-Pten", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10488409", "map_id": "Q7KMQ6", "name": "phospho-Pten", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488401", "map_id": "none", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488399", "map_id": "Q7KMQ6", "name": "phospho-Pten", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10486309", "map_id": "none", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486306", "map_id": "Q7KMQ6", "name": "Pten", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479271", "map_id": "Q9VZU7", "name": "Usp5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035402", "map_id": "FBgn0035402", "name": "Usp5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487829", "map_id": "none", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487825", "map_id": "Q9V9J3", "name": "phospho-Src42A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10487827", "map_id": "none", "name": "PTEN:p-Y387-FRK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10493528", "map_id": "none", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10487835", "map_id": "none", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487832", "map_id": "Q7KMQ6", "name": "phospho-Pten", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10493533", "map_id": "none", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10488413", "map_id": "none", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488411", "map_id": "none", "name": "PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10486303", "map_id": "none", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486296", "map_id": "Q7KMQ6", "name": "Pten", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486300", "map_id": "none", "name": "NEDD4,STUB1,WWP2 and XIAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10441198", "map_id": "none", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441192", "map_id": "Q94533", "name": "S6k", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10441196", "map_id": "Q94533", "name": "phospho-S6k", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10441208", "map_id": "none", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10441203", "map_id": "P49869", "name": "Hr38", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0014859", "map_id": "FBgn0014859", "name": "phospho-Hr38", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441206", "map_id": "P49869", "name": "phospho-Hr38", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10441123", "map_id": "none", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10434463", "map_id": "none", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10434429", "map_id": "P32865", "name": "Gprk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10434460", "map_id": "P32865", "name": "phospho-Gprk1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10434454", "map_id": "none", "name": "active PKC (alpha, gamma, delta)", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10434389", "map_id": "none", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10434384", "map_id": "none", "name": "Adenylate cyclase (Mg2+ cofactor)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9V9R3", "map_id": "Q9V9R3", "name": "Ac3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023416", "map_id": "FBgn0023416", "name": "Ac3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VP76", "map_id": "Q9VP76", "name": "Ac78C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024150", "map_id": "FBgn0024150", "name": "Ac78C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW60", "map_id": "Q9VW60", "name": "Ac76E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004852", "map_id": "FBgn0004852", "name": "Ac76E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK50", "map_id": "Q9VK50", "name": "ACXE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040506", "map_id": "FBgn0040506", "name": "ACXE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK53", "map_id": "Q9VK53", "name": "ACXC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040508", "map_id": "FBgn0040508", "name": "ACXC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W038", "map_id": "Q9W038", "name": "ACXD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040507", "map_id": "FBgn0040507", "name": "ACXD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRF5", "map_id": "Q8IRF5", "name": "CG8970", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052305", "map_id": "FBgn0052305", "name": "CG8970", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK52", "map_id": "Q9VK52", "name": "ACXB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040509", "map_id": "FBgn0040509", "name": "ACXB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W037", "map_id": "Q9W037", "name": "CG8970", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JNU1", "map_id": "A8JNU1", "name": "CG12436", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263131", "map_id": "FBgn0263131", "name": "CG12436", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK51", "map_id": "Q9VK51", "name": "ACXA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040510", "map_id": "FBgn0040510", "name": "ACXA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32870", "map_id": "P32870", "name": "rut", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003301", "map_id": "FBgn0003301", "name": "rut", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PEP2", "map_id": "M9PEP2", "name": "Ac13E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022710", "map_id": "FBgn0022710", "name": "Ac13E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10434456", "map_id": "none", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434431", "map_id": "none", "name": "GRK2:CALM1:4xCa2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10434412", "map_id": "none", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434407", "map_id": "none", "name": "activated PDE1 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B7YZV4", "map_id": "B7YZV4", "name": "Pde1c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264815", "map_id": "FBgn0264815", "name": "Pde1c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10434410", "map_id": "none", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10440803", "map_id": "none", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10440800", "map_id": "none", "name": "Phospho-PKC-delta/epsilon", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10497028", "map_id": "none", "name": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10497022", "map_id": "none", "name": "EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10497024", "map_id": "none", "name": "GRB2-1:VAV1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10497026", "map_id": "none", "name": "EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10496920", "map_id": "none", "name": "EPOR-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10496917", "map_id": "none", "name": "EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10462046", "map_id": "none", "name": "ITCH ubiquitinates DTX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10462041", "map_id": "none", "name": "DTX:ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q23985", "map_id": "Q23985", "name": "dx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "dx", "map_id": "dx", "name": "dx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10462043", "map_id": "none", "name": "Ub-DTX:ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10462467", "map_id": "none", "name": "ITCH binds DTX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10462035", "map_id": "Q23985", "name": "dx", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10462113", "map_id": "none", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10462097", "map_id": "none", "name": "NOTCH4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10462106", "map_id": "none", "name": "NOTCH4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10462111", "map_id": "Q9W4K0", "name": "CHOp24", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "FBgn0029709", "map_id": "FBgn0029709", "name": "CHOp24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497378", "map_id": "none", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497371", "map_id": "Q7KU08", "name": "phospho-wry", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10471742", "map_id": "none", "name": "P4HB forms mixed disulphides with Hh precursors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10471730", "map_id": "Q02936", "name": "hh", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10468383", "map_id": "P54399", "name": "Pdi", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "FBgn0286818", "map_id": "FBgn0286818", "name": "phospho-Pdi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471740", "map_id": "none", "name": "NglycoAsn-Hh precursors:P4HB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "P54399", "map_id": "P54399", "name": "phospho-Pdi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02936", "map_id": "Q02936", "name": "hh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "hh", "map_id": "hh", "name": "hh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471950", "map_id": "none", "name": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10471897", "map_id": "none", "name": "C-terminal Hh fragments:OS9/ERLEC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10471918", "map_id": "none", "name": "SEL1:SYVN1 dimer:DERL2:VCP hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VEU2", "map_id": "Q9VEU2", "name": "Der-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038438", "map_id": "FBgn0038438", "name": "Der-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95SP2", "map_id": "Q95SP2", "name": "sip3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039875", "map_id": "FBgn0039875", "name": "sip3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471920", "map_id": "none", "name": "C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10471948", "map_id": "none", "name": "C-terminal Hh fragments are bound by lectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10471895", "map_id": "Q9VKC7", "name": "Dmel\\CG6766", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_927893", "compartment_display": "endoplasmic reticulum quality control compartment", "complex": "false" }, { "id": "species_10471753", "map_id": "Q02936", "name": "hh", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10471932", "map_id": "none", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10471929", "map_id": "none", "name": "ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10471961", "map_id": "none", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471952", "map_id": "Q02936", "name": "hh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1132287", "map_id": "CHEBI:18367", "name": "phosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "reaction_10471975", "map_id": "none", "name": "Hh-Np traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10471763", "map_id": "Q02936", "name": "hh", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10471934", "map_id": "Q02936", "name": "hh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10471958", "map_id": "none", "name": "Hh C-terminal fragments are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10471890", "map_id": "none", "name": "Glycosylation of Hh", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10471884", "map_id": "Q02936", "name": "hh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10471999", "map_id": "none", "name": "NOTUM releases Hh-Np:GPC5 from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10471944", "map_id": "none", "name": "Hh-Np:GPI-GPC5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10471991", "map_id": "none", "name": "Hh-Np:GPC5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10471996", "map_id": "Q9VUX3", "name": "Notum", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "FBgn0044028", "map_id": "FBgn0044028", "name": "phospho-Notum", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471946", "map_id": "none", "name": "Hh-Np binds GPC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10471942", "map_id": "Q24114", "name": "dally", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10471760", "map_id": "none", "name": "Autoproteolytic cleavage of Hh precursors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_174672", "map_id": "CHEBI:16113", "name": "CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10471745", "map_id": "Q02936", "name": "hh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10471776", "map_id": "none", "name": "HHAT palmitoylates Hh N-terminal fragment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5358339", "map_id": "CHEBI:15525", "name": "Palmitoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_162743", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10471773", "map_id": "Q9VZU2", "name": "rasp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10473197", "map_id": "none", "name": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263228", "compartment_display": "ciliary tip" }, { "id": "species_10472996", "map_id": "none", "name": "GLI:SUFU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10473138", "map_id": "none", "name": "GLI:SUFU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "species_10473149", "map_id": "Q9VYM3", "name": "Mks1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030395", "map_id": "FBgn0030395", "name": "Mks1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473166", "map_id": "none", "name": "PCP regulators of Hh", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VPH0", "map_id": "Q9VPH0", "name": "in", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "in", "map_id": "in", "name": "in", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16868", "map_id": "O16868", "name": "fuz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "fuz", "map_id": "fuz", "name": "fuz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473195", "map_id": "none", "name": "anterograde IFT regulators of Hh", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "Q7KRS6", "map_id": "Q7KRS6", "name": "nompB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016919", "map_id": "FBgn0016919", "name": "nompB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W040", "map_id": "Q9W040", "name": "Oseg2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035317", "map_id": "FBgn0035317", "name": "Oseg2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQS5", "map_id": "Q9VQS5", "name": "IFT57", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031550", "map_id": "FBgn0031550", "name": "IFT57", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMC0", "map_id": "Q9VMC0", "name": "IFT52", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031829", "map_id": "FBgn0031829", "name": "IFT52", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473035", "map_id": "none", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10473031", "map_id": "none", "name": "IFT-A complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "Q7KTZ4", "map_id": "Q7KTZ4", "name": "rempA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260933", "map_id": "FBgn0260933", "name": "rempA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZBM3", "map_id": "A1ZBM3", "name": "Oseg6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034452", "map_id": "FBgn0034452", "name": "Oseg6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSJ6", "map_id": "Q9VSJ6", "name": "Oseg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265102", "map_id": "FBgn0265102", "name": "Oseg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W097", "map_id": "Q9W097", "name": "Oseg4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035264", "map_id": "FBgn0035264", "name": "Oseg4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473003", "map_id": "Q86PC9", "name": "ktub", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "FBgn0015721", "map_id": "FBgn0015721", "name": "ktub", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473033", "map_id": "none", "name": "IFT-A complex:TULP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "Q86PC9", "map_id": "Q86PC9", "name": "ktub", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473099", "map_id": "none", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263232", "compartment_display": "ciliary base" }, { "id": "species_10473095", "map_id": "none", "name": "PKA tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "species_10473097", "map_id": "none", "name": "PKA regulatory subunits:cAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "species_10472975", "map_id": "none", "name": "PKA catalytic subunit", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "reaction_10473127", "map_id": "none", "name": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane" }, { "id": "species_10473117", "map_id": "none", "name": "SMO dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "true" }, { "id": "species_10473121", "map_id": "none", "name": "SMO dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "species_10473125", "map_id": "P18502", "name": "ptc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "false" }, { "id": "reaction_10472998", "map_id": "none", "name": "GLI proteins bind SUFU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472988", "map_id": "P19538", "name": "ci", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10473083", "map_id": "none", "name": "SCF(beta-TrCP) ubiquitinates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473046", "map_id": "none", "name": "p13S-GLI3:SUFU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "species_10473081", "map_id": "none", "name": "4xub-p13S-Gli3:SUFU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "reaction_10472986", "map_id": "none", "name": "CK1 phosphorylates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472965", "map_id": "none", "name": "p6S-GLI3:SUFU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "species_10472983", "map_id": "none", "name": "p10S-GLI3:SUFU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "species_10440489", "map_id": "none", "name": "Homologues of CSNK1A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10473048", "map_id": "none", "name": "GSK3 phosphorylates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10473107", "map_id": "none", "name": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473101", "map_id": "P19538", "name": "ci", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10472978", "map_id": "none", "name": "PKA phosphorylates GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263232", "compartment_display": "ciliary base" }, { "id": "species_10472956", "map_id": "none", "name": "GLI3:SUFU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "reaction_10473042", "map_id": "none", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10473039", "map_id": "none", "name": "adenylate cyclases:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10473105", "map_id": "none", "name": "GLI3R translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473103", "map_id": "P19538", "name": "ci", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10473168", "map_id": "none", "name": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263232", "compartment_display": "ciliary base" }, { "id": "species_10473144", "map_id": "none", "name": "GLI:SUFU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263232", "compartment_display": "ciliary base", "complex": "true" }, { "id": "species_10473156", "map_id": "none", "name": "retrograde IFT regulators of Hh", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "Q0E8P6", "map_id": "Q0E8P6", "name": "btv", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023096", "map_id": "FBgn0023096", "name": "btv", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474463", "map_id": "none", "name": "GLI translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263228", "compartment_display": "ciliary tip" }, { "id": "species_10474454", "map_id": "P19538", "name": "phospho-ci", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "false" }, { "id": "species_10474442", "map_id": "P19538", "name": "phospho-ci", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10474461", "map_id": "none", "name": "ULK3 phosphorylates GLI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5263228", "compartment_display": "ciliary tip" }, { "id": "species_5632460", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "species_10473130", "map_id": "P19538", "name": "ci", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "false" }, { "id": "species_5632457", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "false" }, { "id": "species_10474435", "map_id": "Q9VHF6", "name": "Aduk", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "false" }, { "id": "FBgn0037679", "map_id": "FBgn0037679", "name": "Aduk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474491", "map_id": "none", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474489", "map_id": "none", "name": "ub-2p-GLI2,3:SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10474487", "map_id": "none", "name": "SPOP:CUL3:RBX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10474521", "map_id": "none", "name": "ub-GLI is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474512", "map_id": "none", "name": "ub-GLI1:NUMB:ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10474519", "map_id": "none", "name": "SMURF1/2 dissociates from ub-PTCH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10474517", "map_id": "none", "name": "ub-PTCH1:SMURF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "P18502", "map_id": "P18502", "name": "ptc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ptc", "map_id": "ptc", "name": "ptc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474372", "map_id": "P18502", "name": "ptc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "false" }, { "id": "reaction_10474515", "map_id": "none", "name": "NUMB:ITCH ubiquitinates GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474506", "map_id": "none", "name": "GLI1:NUMB:ITCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10474363", "map_id": "none", "name": "Hh-Npp binds CDON and PTCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10474355", "map_id": "Q02936", "name": "hh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10474361", "map_id": "none", "name": "Hh-Npp:CDON:PTCH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "reaction_10474508", "map_id": "none", "name": "NUMB:ITCH binds GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10474376", "map_id": "none", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10474374", "map_id": "P18502", "name": "ptc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_24337", "compartment_display": "endocytic vesicle membrane", "complex": "false" }, { "id": "reaction_10474504", "map_id": "none", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474493", "map_id": "none", "name": "2p-GLI:SPOP:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10474439", "map_id": "none", "name": "ULK3:SUFU dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10474437", "map_id": "none", "name": "ULK3:SUFU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "Q9VHF6", "map_id": "Q9VHF6", "name": "Aduk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473136", "map_id": "Q9VG38", "name": "Su(fu)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "false" }, { "id": "reaction_10474500", "map_id": "none", "name": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474450", "map_id": "P19538", "name": "phospho-ci", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10474498", "map_id": "Q9VC70", "name": "DZIP1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0039201", "map_id": "FBgn0039201", "name": "DZIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474467", "map_id": "none", "name": "GLI proteins bind CDC73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474448", "map_id": "P19538", "name": "phospho-ci", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10474465", "map_id": "none", "name": "CDC73:2p-GLI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10442699", "map_id": "none", "name": "IkB is ubiquitinated and degraded", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442697", "map_id": "none", "name": "Ubiquitinated phospho-IkB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440308", "map_id": "none", "name": "NF-kB migrates to the nucleus and turns on transcription", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10440364", "map_id": "none", "name": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10440360", "map_id": "none", "name": "RHOA:GDP:ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VZ84", "map_id": "Q9VZ84", "name": "Dmel\\CG7509", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035575", "map_id": "FBgn0035575", "name": "Dmel\\CG7509", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS84", "map_id": "Q9VS84", "name": "ltl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0268063", "map_id": "FBgn0268063", "name": "ltl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KIN0", "map_id": "Q7KIN0", "name": "Toll-7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034476", "map_id": "FBgn0034476", "name": "Toll-7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10440362", "map_id": "none", "name": "ARHGDIA:NGFR:RTN4R:LINGO1:RTN4,MAG,OMG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10440455", "map_id": "none", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10440452", "map_id": "Q7K4E0", "name": "CG12183", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10496236", "map_id": "none", "name": "The p75NTR:NgR:MDGI binds RHOA-GDI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10440358", "map_id": "none", "name": "NGFR:RTN4R:LINGO1:RTN4,MAG,OMG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10440314", "map_id": "none", "name": "RHOA:GDP:ARHGDIA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444395", "map_id": "none", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10444389", "map_id": "P91685", "name": "mGluR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0019985", "map_id": "FBgn0019985", "name": "mGluR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444393", "map_id": "none", "name": "GRM1-8:L-Glu", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91685", "map_id": "P91685", "name": "mGluR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497512", "map_id": "none", "name": "3-agonists bind ADRB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9611836", "map_id": "none", "name": "\u03b23-agonists", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10445401", "map_id": "Q9VBG4", "name": "Dmel\\CG12290", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0039419", "map_id": "FBgn0039419", "name": "Dmel\\CG12290", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497510", "map_id": "none", "name": "\u03b23-agonists:ADBR3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VBG4", "map_id": "Q9VBG4", "name": "Dmel\\CG12290", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497514", "map_id": "none", "name": "ADRB3 bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_390627", "map_id": "none", "name": "ADR, NAd", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10445403", "map_id": "none", "name": "ADRB3:ADR,NAd", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10497386", "map_id": "none", "name": "ADRB1,2,3:\u03b2-blockers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10497388", "map_id": "none", "name": "-blockers bind ADRB1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9609307", "map_id": "none", "name": "\u03b2-blockers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10446674", "map_id": "none", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445692", "map_id": "P22270", "name": "Oct-TyrR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0004514", "map_id": "FBgn0004514", "name": "Oct-TyrR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445696", "map_id": "none", "name": "ADRA2A,B,C:ADR,NAd", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P22270", "map_id": "P22270", "name": "Oct-TyrR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446680", "map_id": "none", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445685", "map_id": "none", "name": "DRD3,4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8IS44", "map_id": "Q8IS44", "name": "Dop2R", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053517", "map_id": "FBgn0053517", "name": "Dop2R", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P28285", "map_id": "P28285", "name": "5-HT1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004168", "map_id": "FBgn0004168", "name": "5-HT1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P28286", "map_id": "P28286", "name": "5-HT1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263116", "map_id": "FBgn0263116", "name": "5-HT1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445687", "map_id": "none", "name": "DRD3,4:DA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446678", "map_id": "none", "name": "DRD1,5 bind DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445408", "map_id": "Q4LBB9", "name": "Octbeta2R", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0038063", "map_id": "FBgn0038063", "name": "Octbeta2R", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445412", "map_id": "none", "name": "DRD1,5:DA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q4LBB9", "map_id": "Q4LBB9", "name": "Octbeta2R", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498330", "map_id": "none", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10498326", "map_id": "Q8IS44", "name": "Dop2R", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10498328", "map_id": "none", "name": "DRD2:DA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446686", "map_id": "none", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445424", "map_id": "none", "name": "HTR4,6,7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P20905", "map_id": "P20905", "name": "5-HT7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004573", "map_id": "FBgn0004573", "name": "5-HT7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41596", "map_id": "P41596", "name": "Dop1R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011582", "map_id": "FBgn0011582", "name": "Dop1R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445426", "map_id": "none", "name": "HTR4,6,7:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446684", "map_id": "none", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445666", "map_id": "none", "name": "Homologues of HTR5A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10445668", "map_id": "none", "name": "HTR1B,D,E,F,HTR5A:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498659", "map_id": "none", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10498655", "map_id": "none", "name": "Homologues of HTR1A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10498657", "map_id": "none", "name": "HTR1A:5HT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446676", "map_id": "none", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445698", "map_id": "P16395", "name": "mAChR-A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10445702", "map_id": "none", "name": "CHRM2,CHRM4:AcCho", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446672", "map_id": "none", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445550", "map_id": "P16395", "name": "mAChR-A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10445556", "map_id": "none", "name": "CHRM1,3,5:AcCho", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446688", "map_id": "none", "name": "Trace amine-associated receptors can bind trace amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445431", "map_id": "Q9W3V5", "name": "mAChR-C", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0029909", "map_id": "FBgn0029909", "name": "mAChR-C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_391200", "map_id": "CHEBI:18397", "name": "PEA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10445445", "map_id": "none", "name": "Trace amine-associated receptor:PEA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W3V5", "map_id": "Q9W3V5", "name": "mAChR-C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10447672", "map_id": "none", "name": "Melanospin is stimulated by light", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_419777", "map_id": "CHEBI:30212", "name": "Photon", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10445561", "map_id": "O01668", "name": "Rh6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "FBgn0019940", "map_id": "FBgn0019940", "name": "Rh6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445563", "map_id": "none", "name": "Melanospin:photon", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "O01668", "map_id": "O01668", "name": "Rh6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446747", "map_id": "none", "name": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445459", "map_id": "none", "name": "Thyrostimulin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A0A6I8WFJ4", "map_id": "A0A6I8WFJ4", "name": "Gpa2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261386", "map_id": "FBgn0261386", "name": "Gpa2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V4C8", "map_id": "Q4V4C8", "name": "Gpb5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0063368", "map_id": "FBgn0063368", "name": "Gpb5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445450", "map_id": "Q9VEG4", "name": "Lgr1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0016650", "map_id": "FBgn0016650", "name": "Lgr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445461", "map_id": "none", "name": "TSHR:Thyrotropin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VEG4", "map_id": "Q9VEG4", "name": "Lgr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10447588", "map_id": "none", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445466", "map_id": "Q9VAA2", "name": "AdoR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0039747", "map_id": "FBgn0039747", "name": "AdoR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445470", "map_id": "none", "name": "ADORA2A,B:Ade-Rib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VAA2", "map_id": "Q9VAA2", "name": "AdoR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10447586", "map_id": "none", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445704", "map_id": "Q9VAA2", "name": "AdoR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10445708", "map_id": "none", "name": "ADORA1,3:Ade-Rib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450073", "map_id": "none", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_444840", "map_id": "none", "name": "Bile acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:28834", "map_id": "CHEBI:28834", "name": "CHEBI:28834", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176655", "map_id": "CHEBI:16325", "name": "LCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10445494", "map_id": "Q9VAA2", "name": "AdoR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10445496", "map_id": "none", "name": "GPBAR1: Bile acids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446753", "map_id": "none", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445718", "map_id": "none", "name": "Homologues of PTGDR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A0A0S0WMT8", "map_id": "A0A0S0WMT8", "name": "AstC-R2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036789", "map_id": "FBgn0036789", "name": "AstC-R2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVQ1", "map_id": "Q9VVQ1", "name": "AstC-R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036790", "map_id": "FBgn0036790", "name": "AstC-R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTU7", "map_id": "Q9VTU7", "name": "Rh7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036260", "map_id": "FBgn0036260", "name": "Rh7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U721", "map_id": "Q9U721", "name": "AstA-R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266429", "map_id": "FBgn0266429", "name": "AstA-R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445720", "map_id": "none", "name": "PTGDR2:PGD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498546", "map_id": "none", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445565", "map_id": "Q9NBC8", "name": "AstA-R2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0039595", "map_id": "FBgn0039595", "name": "AstA-R2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_416372", "map_id": "none", "name": "LTC4,LTD4,LTE4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_266074", "map_id": "CHEBI:28666", "name": "LTD4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_266013", "map_id": "CHEBI:16978", "name": "LTC4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_266033", "map_id": "CHEBI:15650", "name": "LTE4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10445567", "map_id": "none", "name": "CYSLTR1:LTC4,LTD4,LTE4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9NBC8", "map_id": "Q9NBC8", "name": "AstA-R2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498535", "map_id": "none", "name": "CYSLTR1:CYSLTR1 antagonists", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498537", "map_id": "none", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9684615", "map_id": "none", "name": "CYSLTR1 antagonists", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10446757", "map_id": "none", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445569", "map_id": "Q9NBC8", "name": "AstA-R2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10445571", "map_id": "none", "name": "CYSLTR2:LTC4,LTD4,LTE4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446755", "map_id": "none", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445573", "map_id": "Q9NBC8", "name": "AstA-R2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_416436", "map_id": "CHEBI:15647", "name": "LTB4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10445577", "map_id": "none", "name": "LTB4R,LTB4R2:LTB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447656", "map_id": "none", "name": "Melatonin receptors can bind melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_419339", "map_id": "CHEBI:16796", "name": "MLT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10445738", "map_id": "none", "name": "Melatonin receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W534", "map_id": "Q9W534", "name": "moody", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025631", "map_id": "FBgn0025631", "name": "moody", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W533", "map_id": "Q9W533", "name": "EG:22E5.10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025632", "map_id": "FBgn0025632", "name": "EG:22E5.10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NDM2", "map_id": "Q9NDM2", "name": "Tre1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0046687", "map_id": "FBgn0046687", "name": "Tre1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445740", "map_id": "none", "name": "Melatonin receptors:melatonin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10450092", "map_id": "none", "name": "Relaxin receptor 2 binds relaxin 2 and INSL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445490", "map_id": "none", "name": "Insulin-like peptide 3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10445482", "map_id": "none", "name": "Homologues of RXFP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "X2JJX6", "map_id": "X2JJX6", "name": "Lgr4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085440", "map_id": "FBgn0085440", "name": "Lgr4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBP0", "map_id": "Q9VBP0", "name": "Lgr3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039354", "map_id": "FBgn0039354", "name": "Lgr3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445492", "map_id": "none", "name": "RXFP2:RXFP2 ligands", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10497587", "map_id": "none", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9615246", "map_id": "none", "name": "ARBs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10444647", "map_id": "none", "name": "Homologues of AGTR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444713", "map_id": "none", "name": "ARBs:AGTR1", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444715", "map_id": "none", "name": "AGT(34-41) binds to AGTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10444711", "map_id": "none", "name": "AGTR1:AGT(34-41)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10497589", "map_id": "none", "name": "AGT(34-41) binds to AGTR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445652", "map_id": "Q9W533", "name": "EG:22E5.10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10445654", "map_id": "none", "name": "AGTR2:AGT(34-41)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10481289", "map_id": "none", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_417891", "map_id": "CHEBI:52288", "name": "LPA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_6797635", "map_id": "CHEBI:17815", "name": "1,2-DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10481286", "map_id": "Q8IGV3", "name": "WUN-like", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10454110", "map_id": "none", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10445742", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10445746", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10437323", "map_id": "none", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10434469", "map_id": "none", "name": "G-protein alpha:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10437302", "map_id": "none", "name": "G protein-GDP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10437321", "map_id": "none", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437316", "map_id": "none", "name": "Opioid:MOR:G-protein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10434583", "map_id": "none", "name": "Opioid:MOR:G protein-GTP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10437318", "map_id": "none", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437304", "map_id": "none", "name": "Opioid:MOR:G protein-GDP complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10437300", "map_id": "none", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10434217", "map_id": "none", "name": "G protein alpha:GTP complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498096", "map_id": "none", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438771", "map_id": "Q9W4T4", "name": "phospho-dnc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0000479", "map_id": "FBgn0000479", "name": "dnc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10434424", "map_id": "none", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434417", "map_id": "Q9W4T4", "name": "dnc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10438774", "map_id": "none", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438768", "map_id": "Q9W4T4", "name": "dnc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10437758", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437751", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q05337", "map_id": "Q05337", "name": "Galphaf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010223", "map_id": "FBgn0010223", "name": "Galphaf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20354", "map_id": "P20354", "name": "Galphas", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001123", "map_id": "FBgn0001123", "name": "Galphas", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10437755", "map_id": "none", "name": "(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10437771", "map_id": "none", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437769", "map_id": "none", "name": "(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10437753", "map_id": "none", "name": "G alpha-olf:GDP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10437783", "map_id": "none", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10437760", "map_id": "none", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437749", "map_id": "none", "name": "G-protein alpha (i):GTP:Adenylate cyclase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10437740", "map_id": "none", "name": "G alpha-olf:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10434222", "map_id": "none", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434219", "map_id": "none", "name": "Activated PLC beta 1/4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10434471", "map_id": "none", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434186", "map_id": "none", "name": "PLC-beta", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10437774", "map_id": "none", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437762", "map_id": "none", "name": "G alpha-olf:GTP:Adenylate cyclase (active) complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10437765", "map_id": "none", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10437781", "map_id": "none", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437776", "map_id": "none", "name": "G alpha-olf:GDP:Adenylate cyclase (active) complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10437778", "map_id": "none", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10454108", "map_id": "none", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445750", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10437747", "map_id": "none", "name": "G alpha (i): GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495699", "map_id": "none", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10495697", "map_id": "none", "name": "G alpha (i):GDP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8T017", "map_id": "Q8T017", "name": "Dhit", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028743", "map_id": "FBgn0028743", "name": "Dhit", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCX1", "map_id": "Q9VCX1", "name": "loco", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020278", "map_id": "FBgn0020278", "name": "loco", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495695", "map_id": "none", "name": "RGS1,3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495369", "map_id": "none", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10495361", "map_id": "none", "name": "G alpha (i):GTP:SRC-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10495366", "map_id": "none", "name": "G protein alpha (i):GTP:p-Y416-SRC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495371", "map_id": "none", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495364", "map_id": "P00528", "name": "phospho-Src64B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10495707", "map_id": "none", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10495705", "map_id": "none", "name": "G alpha (i):GTP:RGS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10454114", "map_id": "none", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10495710", "map_id": "none", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10445760", "map_id": "none", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_947587", "compartment_display": "cytoplasmic side of plasma membrane" }, { "id": "species_10445756", "map_id": "Q9VB22", "name": "pins", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0040080", "map_id": "FBgn0040080", "name": "pins", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454106", "map_id": "none", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454097", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10454103", "map_id": "none", "name": "ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447293", "map_id": "none", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447291", "map_id": "none", "name": "G-protein alpha (q):GRK2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495715", "map_id": "none", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10495701", "map_id": "none", "name": "G alpha (q):GTP:RGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10495712", "map_id": "none", "name": "G alpha (q):GDP:RGS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447579", "map_id": "none", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10434979", "map_id": "none", "name": "G-protein alpha (q/11):GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447577", "map_id": "Q8T017", "name": "Dhit", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10495717", "map_id": "none", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10445588", "map_id": "none", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445581", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10445583", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10445585", "map_id": "none", "name": "LTC4:CyslTR1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447284", "map_id": "none", "name": "G alpha (q) binds to Trio family RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447280", "map_id": "Q7KVD1", "name": "trio", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10447282", "map_id": "none", "name": "G-protein alpha (q/11):Trio family RhoGEFs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453966", "map_id": "none", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10434981", "map_id": "none", "name": "Heterotrimeric G-protein Gq/11 (inactive)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10445579", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gq/11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10454089", "map_id": "none", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10454081", "map_id": "none", "name": "GPCRs that activate Gq/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "Q9VFW6", "map_id": "Q9VFW6", "name": "PK2-R2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038139", "map_id": "FBgn0038139", "name": "PK2-R2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFW5", "map_id": "Q9VFW5", "name": "PK2-R1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038140", "map_id": "FBgn0038140", "name": "PK2-R1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ITC9", "map_id": "Q8ITC9", "name": "PK1-R", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038201", "map_id": "FBgn0038201", "name": "PK1-R", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8ITC7", "map_id": "Q8ITC7", "name": "CapaR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037100", "map_id": "FBgn0037100", "name": "CapaR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VML9", "map_id": "Q9VML9", "name": "TrissinR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085410", "map_id": "FBgn0085410", "name": "TrissinR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IN35", "map_id": "Q8IN35", "name": "SIFaR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038880", "map_id": "FBgn0038880", "name": "SIFaR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTL9", "map_id": "Q7KTL9", "name": "AkhR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025595", "map_id": "FBgn0025595", "name": "AkhR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V622", "map_id": "Q4V622", "name": "CCHa2-R", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033058", "map_id": "FBgn0033058", "name": "CCHa2-R", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAX0", "map_id": "A1ZAX0", "name": "CCHa1-R", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050106", "map_id": "FBgn0050106", "name": "CCHa1-R", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10454087", "map_id": "none", "name": "Ligands of GPCRs that activate Gq/11", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "P14599", "map_id": "P14599", "name": "Appl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000108", "map_id": "FBgn0000108", "name": "Appl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28716", "map_id": "CHEBI:28716", "name": "CHEBI:28716", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3632881", "map_id": "CHEBI:15756", "name": "PALM", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:28875", "map_id": "CHEBI:28875", "name": "CHEBI:28875", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53460", "map_id": "CHEBI:53460", "name": "CHEBI:53460", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27997", "map_id": "CHEBI:27997", "name": "CHEBI:27997", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53487", "map_id": "CHEBI:53487", "name": "CHEBI:53487", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53486", "map_id": "CHEBI:53486", "name": "CHEBI:53486", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:53488", "map_id": "CHEBI:53488", "name": "CHEBI:53488", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28661", "map_id": "CHEBI:28661", "name": "CHEBI:28661", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28364", "map_id": "CHEBI:28364", "name": "CHEBI:28364", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:27432", "map_id": "CHEBI:27432", "name": "CHEBI:27432", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:52450", "map_id": "CHEBI:52450", "name": "CHEBI:52450", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:31011", "map_id": "CHEBI:31011", "name": "CHEBI:31011", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:50122", "map_id": "CHEBI:50122", "name": "CHEBI:50122", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_33549", "map_id": "CHEBI:30805", "name": "DDCX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "CHEBI:42504", "map_id": "CHEBI:42504", "name": "CHEBI:42504", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17120", "map_id": "CHEBI:17120", "name": "CHEBI:17120", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_209849", "map_id": "CHEBI:15765", "name": "L-Dopa", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:15627", "map_id": "CHEBI:15627", "name": "CHEBI:15627", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495703", "map_id": "none", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10465276", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465273", "map_id": "none", "name": "GRB2:SOS1:HB-EGF:p-6Y-EGFR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10465281", "map_id": "none", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10465278", "map_id": "Q9W122", "name": "Mmp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10447182", "map_id": "none", "name": "Protein Kinase C, alpha type: DAG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447184", "map_id": "none", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10454112", "map_id": "none", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10435008", "map_id": "none", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10435003", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):PIP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10435005", "map_id": "none", "name": "PLC-beta:G-alpha(q/11):DAG:IP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498738", "map_id": "none", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10445545", "map_id": "none", "name": "Liganded Gs-activating GPCR acts as a GEF for Gs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445536", "map_id": "none", "name": "Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10445542", "map_id": "none", "name": "GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447560", "map_id": "none", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447557", "map_id": "none", "name": "cAMP PDEs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6NNF2", "map_id": "Q6NNF2", "name": "Pde8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266377", "map_id": "FBgn0266377", "name": "Pde8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4T4", "map_id": "Q9W4T4", "name": "dnc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446862", "map_id": "none", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444613", "map_id": "none", "name": "Homologues of PLXNB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446856", "map_id": "none", "name": "G-protein alpha (12/13):LARG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446860", "map_id": "none", "name": "G-protein alpha (12/13):LARG:Plexin B1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10434925", "map_id": "none", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434913", "map_id": "none", "name": "G-protein alpha (13):GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10434918", "map_id": "A1ZAN6", "name": "RhoGEF2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10434920", "map_id": "none", "name": "G13-activated p115-RhoGEF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447565", "map_id": "none", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10446850", "map_id": "none", "name": "G-protein alpha (12/13):GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447562", "map_id": "none", "name": "G-protein alpha (12/13):GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10454125", "map_id": "none", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10434939", "map_id": "none", "name": "G-protein G12/G13 (inactive)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10454123", "map_id": "none", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454120", "map_id": "none", "name": "Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive).", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10454118", "map_id": "none", "name": "Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active).", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10434923", "map_id": "none", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10446858", "map_id": "none", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442529", "map_id": "A1ZAN6", "name": "RhoGEF2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10447654", "map_id": "none", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10497274", "map_id": "none", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497272", "map_id": "none", "name": "PDK1:AKT:PIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495392", "map_id": "none", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10495375", "map_id": "none", "name": "G-protein beta-gamma complex:Active PAK1:ARHGEF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439137", "map_id": "P40793", "name": "Cdc42", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10495381", "map_id": "none", "name": "G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495379", "map_id": "none", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10495377", "map_id": "none", "name": "G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10495384", "map_id": "none", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10495386", "map_id": "none", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495373", "map_id": "none", "name": "Active PAK1:ARHGEF6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495388", "map_id": "none", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10495390", "map_id": "none", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10446527", "map_id": "none", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10478015", "map_id": "none", "name": "CDC14A,B bind MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10478007", "map_id": "P40417", "name": "phospho-rl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10478009", "map_id": "Q9VLW7", "name": "cdc14", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0031952", "map_id": "FBgn0031952", "name": "cdc14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10478013", "map_id": "none", "name": "p-3S,T MAPK6:CDC14A,B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VLW7", "map_id": "Q9VLW7", "name": "cdc14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476696", "map_id": "none", "name": "p-S857 NCOA3 binds ETV4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476692", "map_id": "Q8MRW5", "name": "Ets96B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0039225", "map_id": "FBgn0039225", "name": "Ets96B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476677", "map_id": "M9ND53", "name": "phospho-tai", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10476694", "map_id": "none", "name": "p-S857 NCOA3:ETV4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8MRW5", "map_id": "Q8MRW5", "name": "Ets96B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476719", "map_id": "none", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476700", "map_id": "Q95V55", "name": "phospho-foxo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10476687", "map_id": "Q95V55", "name": "phospho-foxo", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10476715", "map_id": "none", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476662", "map_id": "P40417", "name": "rl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10478027", "map_id": "none", "name": "MAPK6 binds CCND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476706", "map_id": "P40417", "name": "rl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10457981", "map_id": "Q7KUZ5", "name": "CycD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10478025", "map_id": "none", "name": "MAPK6:CCND3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476682", "map_id": "none", "name": "p-S MAPK6 phosphorylates NCOA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476679", "map_id": "P40417", "name": "phospho-rl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10476712", "map_id": "none", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476708", "map_id": "none", "name": "MAPK4,6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10476702", "map_id": "none", "name": "MAPK4,6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10478023", "map_id": "none", "name": "CDK1 phosphorylates MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10437599", "map_id": "P23572", "name": "phospho-Cdk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10476710", "map_id": "none", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10478020", "map_id": "none", "name": "CDC14A,B dephosphorylate p-3S,T MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10478017", "map_id": "none", "name": "MAPK6:CDC14A,B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10476672", "map_id": "none", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476664", "map_id": "P40417", "name": "rl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10476667", "map_id": "P40417", "name": "phospho-rl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498144", "map_id": "none", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10498135", "map_id": "P08646", "name": "Ras85D", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10498140", "map_id": "P08646", "name": "Ras85D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10480013", "map_id": "none", "name": "ICMT:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VU37", "map_id": "Q9VU37", "name": "ste14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036336", "map_id": "FBgn0036336", "name": "ste14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498142", "map_id": "none", "name": "ICMT:Zn2+:Cysmethynil", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10498305", "map_id": "none", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10498284", "map_id": "P08646", "name": "phospho-Ras85D", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10498303", "map_id": "P08646", "name": "phospho-Ras85D", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10498183", "map_id": "none", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9647934", "map_id": "none", "name": "Palmostatin B", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10498179", "map_id": "none", "name": "LYPLA1 dimer, ABHD17A,B,C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "M9PEW1", "map_id": "M9PEW1", "name": "Apt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042138", "map_id": "FBgn0042138", "name": "Apt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4D6K2Q0", "map_id": "A0A4D6K2Q0", "name": "CG11935", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053096", "map_id": "FBgn0053096", "name": "CG11935", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498181", "map_id": "none", "name": "Palmostatin B:LYPLA1 dimer, ABHD17A,B,C", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498311", "map_id": "none", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498309", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498186", "map_id": "none", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437905", "map_id": "P08646", "name": "Ras85D", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10437907", "map_id": "P08646", "name": "Ras85D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_8848337", "map_id": "CHEBI:7896", "name": "PALM(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498157", "map_id": "none", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498147", "map_id": "P08646", "name": "Ras85D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2530486", "map_id": "CHEBI:50277", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10498151", "map_id": "P08646", "name": "Ras85D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10466175", "map_id": "none", "name": "FNTA:FNTB", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VR31", "map_id": "Q9VR31", "name": "Fnta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031633", "map_id": "FBgn0031633", "name": "Fnta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEV7", "map_id": "Q9VEV7", "name": "Dmel\\CG17565", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038424", "map_id": "FBgn0038424", "name": "Dmel\\CG17565", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498155", "map_id": "none", "name": "FNTA:FNTB:FTase inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498317", "map_id": "none", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471169", "map_id": "none", "name": "ARL2:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q06849", "map_id": "Q06849", "name": "Arl2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004908", "map_id": "FBgn0004908", "name": "Arl2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498313", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VLJ0", "map_id": "Q9VLJ0", "name": "PrBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032059", "map_id": "FBgn0032059", "name": "PrBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498315", "map_id": "none", "name": "S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498192", "map_id": "none", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10498189", "map_id": "Q9U1H8", "name": "Sras", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0029121", "map_id": "FBgn0029121", "name": "Sras", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498321", "map_id": "none", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473927", "map_id": "Q9VLJ0", "name": "PrBP", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10498319", "map_id": "none", "name": "PDE6D:Deltarasin", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498194", "map_id": "none", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10498196", "map_id": "none", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437899", "map_id": "P08646", "name": "Ras85D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10498324", "map_id": "none", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10498293", "map_id": "none", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498290", "map_id": "none", "name": "PKCZ,PRKG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VL34", "map_id": "Q9VL34", "name": "Dmel\\CG4839", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032187", "map_id": "FBgn0032187", "name": "Dmel\\CG4839", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03043", "map_id": "Q03043", "name": "for", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000721", "map_id": "FBgn0000721", "name": "for", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q03042", "map_id": "Q03042", "name": "Pkg21D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000442", "map_id": "FBgn0000442", "name": "Pkg21D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_30991", "map_id": "CHEBI:16356", "name": "cGMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498166", "map_id": "none", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498160", "map_id": "P08646", "name": "Ras85D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10498168", "map_id": "none", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9653479", "map_id": "none", "name": "FNTB inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498298", "map_id": "none", "name": "USP17L2 deubiquitinates RCE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10498295", "map_id": "Q9U1H8", "name": "Sras", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10477101", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10479178", "map_id": "Q9VRP5", "name": "scny", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0260936", "map_id": "FBgn0260936", "name": "scny", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498300", "map_id": "none", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10498350", "map_id": "none", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498348", "map_id": "none", "name": "p21 RAS:GTP:PI3K", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498362", "map_id": "none", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498358", "map_id": "none", "name": "S-Farn-Me-2xPalmS HRAS:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10498360", "map_id": "none", "name": "S-Farn-Me_2xPalmS HRAS:GTP:RAL GDS proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475845", "map_id": "none", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475842", "map_id": "none", "name": "RAS GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5BIB8", "map_id": "Q5BIB8", "name": "CG17443", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0087011", "map_id": "FBgn0087011", "name": "CG17443", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V4U2", "map_id": "Q4V4U2", "name": "AAF46801", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050280", "map_id": "FBgn0050280", "name": "AAF46801", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQM8", "map_id": "Q9VQM8", "name": "Dmel\\CG34393", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085422", "map_id": "FBgn0085422", "name": "Dmel\\CG34393", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTU3", "map_id": "Q7KTU3", "name": "Dmel\\CG7369", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037188", "map_id": "FBgn0037188", "name": "Dmel\\CG7369", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAU6", "map_id": "A1ZAU6", "name": "Dmel\\CG4853", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034230", "map_id": "FBgn0034230", "name": "Dmel\\CG4853", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMF3", "map_id": "Q9VMF3", "name": "PDZ-GEF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265778", "map_id": "FBgn0265778", "name": "PDZ-GEF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498201", "map_id": "none", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10476045", "map_id": "none", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475910", "map_id": "none", "name": "p21RAS:GTP:activated RAF1 homo/heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475915", "map_id": "Q9VI08", "name": "BcDNA:GH28351", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0037432", "map_id": "FBgn0037432", "name": "BcDNA:GH28351", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475917", "map_id": "none", "name": "p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VI08", "map_id": "Q9VI08", "name": "BcDNA:GH28351", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490146", "map_id": "none", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10490103", "map_id": "none", "name": "PTPN3:p-T183,Y185-MAPK12", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W0R3", "map_id": "Q9W0R3", "name": "Ptpmeg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10490143", "map_id": "none", "name": "p-S459 PTPN3:p-T183,Y185-MAPK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476043", "map_id": "none", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475991", "map_id": "none", "name": "p-T,Y MAPK monomers and dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10476027", "map_id": "none", "name": "MAPK monomers and dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10476040", "map_id": "none", "name": "cytosolic MAPK DUSPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475978", "map_id": "none", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10475782", "map_id": "P11346", "name": "phospho-Raf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475974", "map_id": "Q9VFG7", "name": "Dmel\\CG7530", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0038256", "map_id": "FBgn0038256", "name": "Dmel\\CG7530", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475976", "map_id": "none", "name": "PAQR3:inactive RAFs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VFG7", "map_id": "Q9VFG7", "name": "Dmel\\CG7530", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476055", "map_id": "none", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10476049", "map_id": "none", "name": "p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10476053", "map_id": "none", "name": "p21RAS:GTP:p-S621 RAF1 homo/heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10476009", "map_id": "P11346", "name": "phospho-Raf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10490105", "map_id": "none", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10490101", "map_id": "Q9W0R3", "name": "Ptpmeg", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10450702", "map_id": "none", "name": "Homologues of p-T183,Y185-MAPK12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10490108", "map_id": "none", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451567", "map_id": "none", "name": "Homologues of MAPK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476011", "map_id": "none", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475854", "map_id": "P11346", "name": "phospho-Raf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10476019", "map_id": "none", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475856", "map_id": "P11346", "name": "phospho-Raf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10476017", "map_id": "P11346", "name": "phospho-Raf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10476002", "map_id": "none", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475867", "map_id": "none", "name": "p-2S MAP2K1:p-2S MAPK2K2 heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10475999", "map_id": "none", "name": "p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497901", "map_id": "none", "name": "PTPN7 dephosphorylates p-T,Y-MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497886", "map_id": "none", "name": "PTPN7:p-T,Y-MAPK dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W2F3", "map_id": "Q9W2F3", "name": "PTP-ER", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016641", "map_id": "FBgn0016641", "name": "PTP-ER", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497898", "map_id": "none", "name": "PTPN7:p-T-MAPK dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476064", "map_id": "none", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10476061", "map_id": "Q9VH81", "name": "PpD3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0005777", "map_id": "FBgn0005777", "name": "PpD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497903", "map_id": "none", "name": "PTPN7 binds p-T,Y-MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497884", "map_id": "Q9W2F3", "name": "PTP-ER", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498198", "map_id": "none", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10475919", "map_id": "none", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475862", "map_id": "none", "name": "p21 RAS:GTP:activated RAF homo/heterodimer complexes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475896", "map_id": "none", "name": "RAF/MAPK scaffolds", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475908", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475967", "map_id": "none", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10475963", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q9VJL9", "map_id": "Q9VJL9", "name": "MET30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028897", "map_id": "FBgn0028897", "name": "MET30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10475965", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10498338", "map_id": "none", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657567", "map_id": "none", "name": "dual mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475929", "map_id": "none", "name": "activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475933", "map_id": "none", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475922", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475924", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475931", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475927", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498340", "map_id": "none", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657570", "map_id": "none", "name": "dual mechanism MAPK inhibitors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498342", "map_id": "none", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657574", "map_id": "none", "name": "single mechanism MAP2K1/2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10475944", "map_id": "none", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10475941", "map_id": "none", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475939", "map_id": "none", "name": "p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498346", "map_id": "none", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657577", "map_id": "none", "name": "single mechanism MAPK inhibitors", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10498344", "map_id": "none", "name": "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475987", "map_id": "none", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10475982", "map_id": "none", "name": "IL17RD:p-2S MAP2Ks:MAPKs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10475984", "map_id": "none", "name": "IL17RD:p-2S MAP2Ks:p-T,Y MAPKs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10475969", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10475959", "map_id": "none", "name": "WDR83:LAMTOR2:LAMTOR3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10475961", "map_id": "none", "name": "activated RAF homo/heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475995", "map_id": "none", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475993", "map_id": "none", "name": "p-T,Y MAPK monomers and dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475803", "map_id": "none", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475790", "map_id": "none", "name": "inactive RAFs:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10475798", "map_id": "none", "name": "dephosphorylated inactive RAFS:YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475851", "map_id": "none", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475771", "map_id": "none", "name": "p21 RAS:GTP:'activator' RAF:YWHAB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475742", "map_id": "P11346", "name": "phospho-Raf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475847", "map_id": "none", "name": "p21 RAS:GTP:homo/heterodimerized RAF complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10475849", "map_id": "Q95UN8", "name": "slpr", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030018", "map_id": "FBgn0030018", "name": "slpr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475800", "map_id": "none", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475878", "map_id": "none", "name": "Phosphorylation of RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475875", "map_id": "none", "name": "RAF activating kinases", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498281", "map_id": "none", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9657579", "map_id": "none", "name": "RAF dimer inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10475778", "map_id": "none", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10475769", "map_id": "none", "name": "'activator' RAF:YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10475776", "map_id": "P24156", "name": "l(2)37Cc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0002031", "map_id": "FBgn0002031", "name": "l(2)37Cc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475792", "map_id": "none", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10433759", "map_id": "none", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10433755", "map_id": "Q24324", "name": "phospho-Dsor1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10434596", "map_id": "none", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434587", "map_id": "none", "name": "MAP2K1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10433794", "map_id": "none", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10498724", "map_id": "none", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10498720", "map_id": "none", "name": "RHOBTB3 interacting proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VIW6", "map_id": "Q9VIW6", "name": "Rab9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032782", "map_id": "FBgn0032782", "name": "Rab9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCI3", "map_id": "Q9VCI3", "name": "Lsd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039114", "map_id": "FBgn0039114", "name": "Lsd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXY7", "map_id": "Q9VXY7", "name": "Lsd-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030608", "map_id": "FBgn0030608", "name": "Lsd-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498704", "map_id": "none", "name": "RHOBTB3:ATP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10498722", "map_id": "none", "name": "RHOBTB3:ATP:RHOBTB3 interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10498726", "map_id": "none", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10498702", "map_id": "none", "name": "Homologues of RHOBTB3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10498731", "map_id": "none", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10498728", "map_id": "none", "name": "RHOBTB3:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10496801", "map_id": "none", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10496812", "map_id": "none", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10496806", "map_id": "Q960V3", "name": "milt", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10496810", "map_id": "none", "name": "RHOT1:GTP:RHOT1 effectors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10458700", "map_id": "none", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458697", "map_id": "none", "name": "KCNJ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10472658", "map_id": "none", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472655", "map_id": "none", "name": "KCNK dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VHE0", "map_id": "Q9VHE0", "name": "Task7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037690", "map_id": "FBgn0037690", "name": "Task7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFS9", "map_id": "Q9VFS9", "name": "Task6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038165", "map_id": "FBgn0038165", "name": "Task6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472583", "map_id": "none", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472580", "map_id": "none", "name": "LTCC multimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VRE6", "map_id": "Q9VRE6", "name": "stg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0064123", "map_id": "FBgn0064123", "name": "stg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24270", "map_id": "Q24270", "name": "Ca-alpha1D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001991", "map_id": "FBgn0001991", "name": "Ca-alpha1D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PD84", "map_id": "M9PD84", "name": "Ca-beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259822", "map_id": "FBgn0259822", "name": "Ca-beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2J9Z3", "map_id": "X2J9Z3", "name": "stol", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028863", "map_id": "FBgn0028863", "name": "stol", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IP22", "map_id": "Q8IP22", "name": "Ca-Ma2d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261999", "map_id": "FBgn0261999", "name": "Ca-Ma2d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472614", "map_id": "none", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10472611", "map_id": "none", "name": "KCND tetramer:KCNIP tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P17971", "map_id": "P17971", "name": "Shal", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005564", "map_id": "FBgn0005564", "name": "Shal", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBL2", "map_id": "Q9VBL2", "name": "Dmel\\CG5890", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039380", "map_id": "FBgn0039380", "name": "Dmel\\CG5890", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IR92", "map_id": "Q8IR92", "name": "CG42683", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265595", "map_id": "FBgn0265595", "name": "CG42683", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472943", "map_id": "none", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10472941", "map_id": "Q9VXH3", "name": "phospho-sl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10472926", "map_id": "Q9VXH3", "name": "phospho-sl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10466943", "map_id": "none", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10466879", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10466941", "map_id": "none", "name": "NFAT:CaN:CaM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10466882", "map_id": "none", "name": "Calcineurin binds and dephosphorylates NFAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10472924", "map_id": "none", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10470925", "map_id": "P83099", "name": "phospho-Pkcdelta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10472922", "map_id": "none", "name": "DAGs:p-T507,S645,S664-PRKCD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10472939", "map_id": "none", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10472937", "map_id": "none", "name": "DAGs:active p-T507,S645,S664-PRKCD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10472929", "map_id": "none", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10489499", "map_id": "none", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489495", "map_id": "none", "name": "Tn antigens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10489479", "map_id": "none", "name": "Homologues of CLEC10A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B7YZU7", "map_id": "B7YZU7", "name": "lectin-22C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259230", "map_id": "FBgn0259230", "name": "lectin-22C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQU4", "map_id": "Q9VQU4", "name": "lectin-24A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040104", "map_id": "FBgn0040104", "name": "lectin-24A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7Z0K3", "map_id": "B7Z0K3", "name": "Dmel\\CG14866", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038315", "map_id": "FBgn0038315", "name": "Dmel\\CG14866", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQX3", "map_id": "Q9VQX3", "name": "lectin-24Db", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040102", "map_id": "FBgn0040102", "name": "lectin-24Db", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C3KGN2", "map_id": "C3KGN2", "name": "nw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283508", "map_id": "FBgn0283508", "name": "nw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3D8", "map_id": "Q9W3D8", "name": "Dmel\\CG12111", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030050", "map_id": "FBgn0030050", "name": "Dmel\\CG12111", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9NE79", "map_id": "M9NE79", "name": "Dmel\\CG43055", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262357", "map_id": "FBgn0262357", "name": "Dmel\\CG43055", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PB26", "map_id": "M9PB26", "name": "Dmel\\CG43797", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264341", "map_id": "FBgn0264341", "name": "Dmel\\CG43797", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q59DY5", "map_id": "Q59DY5", "name": "lectin-37Db", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053533", "map_id": "FBgn0053533", "name": "lectin-37Db", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q59DY6", "map_id": "Q59DY6", "name": "lectin-37Da", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053532", "map_id": "FBgn0053532", "name": "lectin-37Da", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JY62", "map_id": "Q7JY62", "name": "lectin-46Cb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040092", "map_id": "FBgn0040092", "name": "lectin-46Cb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRH8", "map_id": "Q8IRH8", "name": "tfc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035199", "map_id": "FBgn0035199", "name": "tfc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIX1", "map_id": "Q9VIX1", "name": "Lectin-galC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016675", "map_id": "FBgn0016675", "name": "Lectin-galC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKL8", "map_id": "Q9VKL8", "name": "lectin-33A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040096", "map_id": "FBgn0040096", "name": "lectin-33A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLM0", "map_id": "Q9VLM0", "name": "lectin-29Ca", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040098", "map_id": "FBgn0040098", "name": "lectin-29Ca", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM16", "map_id": "Q9VM16", "name": "Dmel\\CG15818", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031910", "map_id": "FBgn0031910", "name": "Dmel\\CG15818", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7Z6", "map_id": "A1Z7Z6", "name": "lectin-46Ca", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040093", "map_id": "FBgn0040093", "name": "lectin-46Ca", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPS1", "map_id": "Q9VPS1", "name": "lectin-21Cb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040106", "map_id": "FBgn0040106", "name": "lectin-21Cb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8L7", "map_id": "A1Z8L7", "name": "CK02422a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040503", "map_id": "FBgn0040503", "name": "CK02422a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPS2", "map_id": "Q9VPS2", "name": "lectin-21Ca", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040107", "map_id": "FBgn0040107", "name": "lectin-21Ca", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B4ZJ93", "map_id": "B4ZJ93", "name": "Sfp24F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259958", "map_id": "FBgn0259958", "name": "Sfp24F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQ53", "map_id": "Q9VQ53", "name": "mdcds_4396", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031373", "map_id": "FBgn0031373", "name": "mdcds_4396", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489497", "map_id": "none", "name": "CLEC10A:Tn antigens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10473885", "map_id": "none", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10446844", "map_id": "P11346", "name": "Raf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10473881", "map_id": "none", "name": "p21 RAS:GTP:RAF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475388", "map_id": "none", "name": "CBP and p300 binds NF-kB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10473850", "map_id": "none", "name": "NFKB1:p-S276-RELA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10475363", "map_id": "none", "name": "NFKB1:p-S276-RELA:p300/CBP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10473883", "map_id": "none", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10473870", "map_id": "none", "name": "p21 RAS:GTP:p-S338-RAF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475386", "map_id": "none", "name": "p300 acetylates RELA subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10475383", "map_id": "none", "name": "NFKB1:p-S276,5AcK-RELA:p300/CBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10473865", "map_id": "none", "name": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10473862", "map_id": "none", "name": "RPS6KA5(MSK1/SAPK1):PKA catalytic subunits", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V3I5", "map_id": "Q9V3I5", "name": "JIL-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473879", "map_id": "none", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10473876", "map_id": "none", "name": "p21 RAS:GTP:p-S338,Y340,Y341-RAF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10475392", "map_id": "none", "name": "p-S276-RELA binds RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10472931", "map_id": "P15330", "name": "dl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10473848", "map_id": "none", "name": "Homologues of p-S276-RELA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10475390", "map_id": "none", "name": "p-S276-RELA:RELB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10486210", "map_id": "none", "name": "EHMT1:EHMT2 dimethylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467611", "map_id": "none", "name": "TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10486207", "map_id": "none", "name": "Me2-K373-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10468978", "map_id": "none", "name": "EHMT1:EHMT2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9PGH7", "map_id": "M9PGH7", "name": "G9a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040372", "map_id": "FBgn0040372", "name": "G9a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467770", "map_id": "none", "name": "SMYD2 methylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427813", "map_id": "none", "name": "p-S15,S20-TP53 Tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10467762", "map_id": "none", "name": "Me1-K370,p-S15,S20-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10467767", "map_id": "Q9W4X8", "name": "Smyd3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0011566", "map_id": "FBgn0011566", "name": "Smyd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486202", "map_id": "none", "name": "SETD8 methylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467744", "map_id": "none", "name": "Me-K382,p-S15,S20-TP53 Tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10486199", "map_id": "Q9VFK6", "name": "PR-Set7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0011474", "map_id": "FBgn0011474", "name": "PR-Set7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467748", "map_id": "none", "name": "L3MBTL1 binds TP53 monomethylated on K382", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467739", "map_id": "Q9VB52", "name": "l(3)mbt", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0002441", "map_id": "FBgn0002441", "name": "l(3)mbt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467746", "map_id": "none", "name": "L3MBTL1:Me-K382,p-S-15,S20-TP53", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VB52", "map_id": "Q9VB52", "name": "l(3)mbt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479851", "map_id": "none", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6786220", "map_id": "CHEBI:36005", "name": "DHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_6786225", "map_id": "CHEBI:72790", "name": "hydroxydocosahexaenoic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10479848", "map_id": "Q9VA27", "name": "Cyp4c3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0015032", "map_id": "FBgn0015032", "name": "Cyp4c3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440259", "map_id": "none", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193066", "map_id": "CHEBI:17263", "name": "E1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440256", "map_id": "none", "name": "Homologues of CYP19A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9V4T5", "map_id": "Q9V4T5", "name": "Cyp4e1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015034", "map_id": "FBgn0015034", "name": "Cyp4e1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W011", "map_id": "Q9W011", "name": "Cyp4d20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035344", "map_id": "FBgn0035344", "name": "Cyp4d20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4T3", "map_id": "Q9V4T3", "name": "Cyp4ad1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033292", "map_id": "FBgn0033292", "name": "Cyp4ad1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYQ7", "map_id": "Q9VYQ7", "name": "Cyp311a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030367", "map_id": "FBgn0030367", "name": "Cyp311a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27606", "map_id": "Q27606", "name": "Cyp4e2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014469", "map_id": "FBgn0014469", "name": "Cyp4e2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXY0", "map_id": "Q9VXY0", "name": "Cyp4s3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030615", "map_id": "FBgn0030615", "name": "Cyp4s3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q27589", "map_id": "Q27589", "name": "Cyp4d2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011576", "map_id": "FBgn0011576", "name": "Cyp4d2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVN6", "map_id": "Q9VVN6", "name": "Cyp312a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036778", "map_id": "FBgn0036778", "name": "Cyp312a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P33269", "map_id": "P33269", "name": "Cyp4d1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005670", "map_id": "FBgn0005670", "name": "Cyp4d1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS79", "map_id": "Q9VS79", "name": "Cyp4d8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015033", "map_id": "FBgn0015033", "name": "Cyp4d8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46054", "map_id": "O46054", "name": "Cyp4ae1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015036", "map_id": "FBgn0015036", "name": "Cyp4ae1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS78", "map_id": "Q9VS78", "name": "Cyp316a1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035790", "map_id": "FBgn0035790", "name": "Cyp316a1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46051", "map_id": "O46051", "name": "Cyp4d14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023541", "map_id": "FBgn0023541", "name": "Cyp4d14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMS9", "map_id": "Q9VMS9", "name": "Cyp4ac1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031693", "map_id": "FBgn0031693", "name": "Cyp4ac1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMS8", "map_id": "Q9VMS8", "name": "Cyp4ac2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031694", "map_id": "FBgn0031694", "name": "Cyp4ac2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMS7", "map_id": "Q9VMS7", "name": "Cyp4ac3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031695", "map_id": "FBgn0031695", "name": "Cyp4ac3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLZ7", "map_id": "Q9VLZ7", "name": "Cyp4d21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031925", "map_id": "FBgn0031925", "name": "Cyp4d21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL92", "map_id": "Q9VL92", "name": "Cyp4e3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015035", "map_id": "FBgn0015035", "name": "Cyp4e3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGH1", "map_id": "Q9VGH1", "name": "sad", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003312", "map_id": "FBgn0003312", "name": "sad", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V7G5", "map_id": "Q9V7G5", "name": "Cyp4aa1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034053", "map_id": "FBgn0034053", "name": "Cyp4aa1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V559", "map_id": "Q9V559", "name": "Cyp4p3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033397", "map_id": "FBgn0033397", "name": "Cyp4p3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V558", "map_id": "Q9V558", "name": "Cyp4p1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015037", "map_id": "FBgn0015037", "name": "Cyp4p1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V557", "map_id": "Q9V557", "name": "Cyp4p2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033395", "map_id": "FBgn0033395", "name": "Cyp4p2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428799", "map_id": "none", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29732", "map_id": "CHEBI:17363", "name": "RU5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29790", "map_id": "CHEBI:57737", "name": "XY5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428796", "map_id": "none", "name": "RPE:Fe2+ dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95RV5", "map_id": "Q95RV5", "name": "Rpe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050499", "map_id": "FBgn0050499", "name": "Rpe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428829", "map_id": "none", "name": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29878", "map_id": "CHEBI:16897", "name": "E4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428814", "map_id": "none", "name": "TKT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VHN7", "map_id": "Q9VHN7", "name": "anon-WO0118547.344", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037607", "map_id": "FBgn0037607", "name": "anon-WO0118547.344", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428827", "map_id": "none", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29882", "map_id": "CHEBI:15721", "name": "SH7P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428824", "map_id": "none", "name": "TALDO1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W1G0", "map_id": "Q9W1G0", "name": "Taldo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023477", "map_id": "FBgn0023477", "name": "Taldo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495142", "map_id": "none", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8955853", "map_id": "CHEBI:47013", "name": "D-ribose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73578", "map_id": "CHEBI:78679", "name": "R5P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10495139", "map_id": "O77425", "name": "Dmel\\CG13369", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0025640", "map_id": "FBgn0025640", "name": "Dmel\\CG13369", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436633", "map_id": "none", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10495719", "map_id": "none", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787326", "map_id": "CHEBI:11563", "name": "dR1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6787328", "map_id": "CHEBI:16132", "name": "dR5P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10427848", "map_id": "none", "name": "PGM2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10427926", "map_id": "none", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31467", "map_id": "CHEBI:16938", "name": "D-Glucono-1,5-lactone 6-phosphate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10427923", "map_id": "none", "name": "G6PD dimer and tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P12646", "map_id": "P12646", "name": "Zw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004057", "map_id": "FBgn0004057", "name": "Zw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438837", "map_id": "none", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428804", "map_id": "Q8MLS2", "name": "Rpi", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0050410", "map_id": "FBgn0050410", "name": "Rpi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10434100", "map_id": "none", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430909", "map_id": "none", "name": "PRPS1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VT33", "map_id": "Q9VT33", "name": "Prps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036030", "map_id": "FBgn0036030", "name": "Prps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430912", "map_id": "none", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10479918", "map_id": "none", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10428779", "map_id": "none", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29996", "map_id": "CHEBI:16863", "name": "PDG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428776", "map_id": "none", "name": "PGD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P41572", "map_id": "P41572", "name": "Pgd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004654", "map_id": "FBgn0004654", "name": "Pgd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479915", "map_id": "none", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29510", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479912", "map_id": "Q7K209", "name": "Dera", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0033735", "map_id": "FBgn0033735", "name": "Dera", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441190", "map_id": "none", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10428769", "map_id": "none", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428766", "map_id": "Q9VZ64", "name": "PGLS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030239", "map_id": "FBgn0030239", "name": "PGLS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_214393", "map_id": "none", "name": "Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Phosphorylated Relish (REL) is endoproteolytically cleaved by the caspase-8 orthologue, DREDD, between residues Asp545 and Gly546 at a consensus target site for group III caspases found in the interdomain linker. The two cleavage products, REL-68 and REL-49, dissociate from DREDD.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_214409", "map_id": "none", "name": "Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD:Phospho REL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_214401", "map_id": "CHEBI:46763", "name": "Mono PGN", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q9VXN9", "map_id": "Q9VXN9", "name": "PGRP-LE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PGRP-LE", "map_id": "PGRP-LE", "name": "PGRP-LE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K4Z4", "map_id": "Q7K4Z4", "name": "IMD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "IMD", "map_id": "IMD", "name": "IMD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3B4", "map_id": "Q9V3B4", "name": "BG4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "BG4", "map_id": "BG4", "name": "BG4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_205709", "map_id": "Q94527", "name": "Phospho REL-49", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_354270", "map_id": "Q94527", "name": "Phospho REL-68", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_214404", "map_id": "none", "name": "Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_205876", "map_id": "Q8IRY7", "name": "DREDD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209167", "map_id": "none", "name": "Phosphorylated REL is cleaved by and dissociates from DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Phosphorylated Relish (REL) is endoproteolytically cleaved by the caspase-8 orthologue, DREDD, between residues Asp545 and Gly546 at a consensus target site for group III caspases found in the interdomain linker. The two cleavage products, REL-68 and REL-49, dissociate from DREDD.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_354322", "map_id": "none", "name": "PGN:PGRP-LC oligomer:IMD:BG4:DREDD:Phospho REL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "CHEBI:28881", "map_id": "CHEBI:28881", "name": "CHEBI:28881", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GNK5-2", "map_id": "Q9GNK5-2", "name": "PGRP-LCx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PGRP-LCx", "map_id": "PGRP-LCx", "name": "PGRP-LCx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9GNK5-1", "map_id": "Q9GNK5-1", "name": "PGRP-LCa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PGRP-LCa", "map_id": "PGRP-LCa", "name": "PGRP-LCa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_354317", "map_id": "none", "name": "PGN:PGRP-LC oligomer:IMD:BG4:DREDD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10436024", "map_id": "none", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449299", "map_id": "CHEBI:16214", "name": "DOLP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_162681", "map_id": "CHEBI:15809", "name": "DOLP-Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10436021", "map_id": "none", "name": "DPM1:DPM2:DPM3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "E1JIA5", "map_id": "E1JIA5", "name": "Dpm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259933", "map_id": "FBgn0259933", "name": "Dpm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIU7", "map_id": "Q9VIU7", "name": "Dpm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032799", "map_id": "FBgn0032799", "name": "Dpm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2PDR0", "map_id": "Q2PDR0", "name": "Dpm3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053977", "map_id": "FBgn0053977", "name": "Dpm3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457726", "map_id": "none", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457724", "map_id": "none", "name": "p-Y701-STAT1 dimer,p-Y705-STAT3 dimer,p-Y701-STAT1:p-Y705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457736", "map_id": "none", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457734", "map_id": "none", "name": "STAT1/3 homo and heterodimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10466124", "map_id": "none", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431457", "map_id": "none", "name": "cGMP:CNG channel", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466121", "map_id": "none", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431455", "map_id": "none", "name": "CNG channel", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10467853", "map_id": "none", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467851", "map_id": "none", "name": "CALM1:Ca2+:CNG channel", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466231", "map_id": "none", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10466229", "map_id": "none", "name": "GUCA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "species_10431940", "map_id": "none", "name": "GUCA:Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "true" }, { "id": "reaction_10431958", "map_id": "none", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane" }, { "id": "species_10431905", "map_id": "A0A4D6K026", "name": "CG9783", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "FBgn0085386", "map_id": "FBgn0085386", "name": "CG9783", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10431946", "map_id": "none", "name": "Homologues of GUCA1B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10431952", "map_id": "none", "name": "Homologues of GUCA1A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10431954", "map_id": "none", "name": "GCAP1:Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10431956", "map_id": "none", "name": "GCAP2:Ca2+", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431459", "map_id": "none", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10479843", "map_id": "none", "name": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428994", "map_id": "none", "name": "Homologues of CALM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10479835", "map_id": "none", "name": "Homologues of Me3K115-CALM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10479840", "map_id": "A4V0X6", "name": "38C.42", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0032857", "map_id": "FBgn0032857", "name": "38C.42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466178", "map_id": "none", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane" }, { "id": "species_10466165", "map_id": "P38040", "name": "Ggamma1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "species_10466168", "map_id": "P38040", "name": "Ggamma1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_2514888", "compartment_display": "photoreceptor disc membrane", "complex": "false" }, { "id": "reaction_10443513", "map_id": "none", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_194276", "map_id": "CHEBI:16110", "name": "phosphatidylcholines", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_194236", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10443510", "map_id": "none", "name": "Homologues of LCAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9I7L9", "map_id": "Q9I7L9", "name": "Dmel\\CG18858", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042175", "map_id": "FBgn0042175", "name": "Dmel\\CG18858", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y168", "map_id": "Q9Y168", "name": "BcDNA.GH02384", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051683", "map_id": "FBgn0051683", "name": "BcDNA.GH02384", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495519", "map_id": "none", "name": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10495516", "map_id": "none", "name": "LIPG dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A1ZAL5", "map_id": "A1ZAL5", "name": "Dmel\\CG6472", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034166", "map_id": "FBgn0034166", "name": "Dmel\\CG6472", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYT7", "map_id": "A8DYT7", "name": "CG9966", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085477", "map_id": "FBgn0085477", "name": "CG9966", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9MRT1", "map_id": "M9MRT1", "name": "chr2L_10724193_10724543.0", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032289", "map_id": "FBgn0032289", "name": "chr2L_10724193_10724543.0", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9NFL7", "map_id": "M9NFL7", "name": "cg5665", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036977", "map_id": "FBgn0036977", "name": "cg5665", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02843", "map_id": "P02843", "name": "Yp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004045", "map_id": "FBgn0004045", "name": "Yp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02844", "map_id": "P02844", "name": "Yp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005391", "map_id": "FBgn0005391", "name": "Yp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P06607", "map_id": "P06607", "name": "Yp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004047", "map_id": "FBgn0004047", "name": "Yp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E8T1", "map_id": "Q0E8T1", "name": "anon-SAGE:Wang-122", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250847", "map_id": "FBgn0250847", "name": "anon-SAGE:Wang-122", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V566", "map_id": "Q4V566", "name": "CG31684", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085476", "map_id": "FBgn0085476", "name": "CG31684", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K3Z8", "map_id": "Q7K3Z8", "name": "Dmel\\CG17292", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032029", "map_id": "FBgn0032029", "name": "Dmel\\CG17292", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB88", "map_id": "Q9VB88", "name": "DmelL1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039476", "map_id": "FBgn0039476", "name": "DmelL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB89", "map_id": "Q9VB89", "name": "DmelL2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039475", "map_id": "FBgn0039475", "name": "DmelL2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB90", "map_id": "Q9VB90", "name": "Dmel\\CG6283", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039474", "map_id": "FBgn0039474", "name": "Dmel\\CG6283", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB91", "map_id": "Q9VB91", "name": "Dmel\\CG17191", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039473", "map_id": "FBgn0039473", "name": "Dmel\\CG17191", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB92", "map_id": "Q9VB92", "name": "Dmel\\CG17192", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039472", "map_id": "FBgn0039472", "name": "Dmel\\CG17192", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB93", "map_id": "Q9VB93", "name": "Dmel\\CG6295", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039471", "map_id": "FBgn0039471", "name": "Dmel\\CG6295", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB94", "map_id": "Q9VB94", "name": "DmelL7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039470", "map_id": "FBgn0039470", "name": "DmelL7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBQ2", "map_id": "Q9VBQ2", "name": "Dmel\\CG4582", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039344", "map_id": "FBgn0039344", "name": "Dmel\\CG4582", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEY9", "map_id": "Q9VEY9", "name": "sxe2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038398", "map_id": "FBgn0038398", "name": "sxe2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJH1", "map_id": "Q9VJH1", "name": "Dmel\\CG13282", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032612", "map_id": "FBgn0032612", "name": "Dmel\\CG13282", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLU1", "map_id": "Q9VLU1", "name": "Dmel\\CG7367", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031976", "map_id": "FBgn0031976", "name": "Dmel\\CG7367", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRW5", "map_id": "Q9VRW5", "name": "Dmel\\CG10163", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035697", "map_id": "FBgn0035697", "name": "Dmel\\CG10163", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VU78", "map_id": "Q9VU78", "name": "Dmel\\CG10116", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036367", "map_id": "FBgn0036367", "name": "Dmel\\CG10116", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX01", "map_id": "Q9VX01", "name": "Dmel\\CG6847", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030884", "map_id": "FBgn0030884", "name": "Dmel\\CG6847", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX69", "map_id": "Q9VX69", "name": "Dmel\\CG5162", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030828", "map_id": "FBgn0030828", "name": "Dmel\\CG5162", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX70", "map_id": "Q9VX70", "name": "CT41369", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265267", "map_id": "FBgn0265267", "name": "CT41369", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZN6", "map_id": "Q9VZN6", "name": "Dmel\\CG10357", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035453", "map_id": "FBgn0035453", "name": "Dmel\\CG10357", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W304", "map_id": "Q9W304", "name": "Dmel\\CG1986", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030162", "map_id": "FBgn0030162", "name": "Dmel\\CG1986", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W448", "map_id": "Q9W448", "name": "141233_at", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029831", "map_id": "FBgn0029831", "name": "141233_at", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459822", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524101", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524064", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10459819", "map_id": "P56079", "name": "Cds", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0010350", "map_id": "FBgn0010350", "name": "Cds", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474159", "map_id": "none", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10474075", "map_id": "none", "name": "anterograde IFT trains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "Q9VUY2", "map_id": "Q9VUY2", "name": "Dmel\\CG13074", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036567", "map_id": "FBgn0036567", "name": "Dmel\\CG13074", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQA6", "map_id": "Q9VQA6", "name": "robl22E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028570", "map_id": "FBgn0028570", "name": "robl22E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24117", "map_id": "Q24117", "name": "ctp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011760", "map_id": "FBgn0011760", "name": "ctp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96860", "map_id": "O96860", "name": "Cdlc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026141", "map_id": "FBgn0026141", "name": "Cdlc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KMS3", "map_id": "Q7KMS3", "name": "robl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024196", "map_id": "FBgn0024196", "name": "robl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLB9", "map_id": "Q9VLB9", "name": "Dmel\\CG3769", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032119", "map_id": "FBgn0032119", "name": "Dmel\\CG3769", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK67", "map_id": "Q9VK67", "name": "IFT43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032446", "map_id": "FBgn0032446", "name": "IFT43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFL0", "map_id": "Q9VFL0", "name": "IFT54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038221", "map_id": "FBgn0038221", "name": "IFT54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VII8", "map_id": "Q9VII8", "name": "Oseg5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032891", "map_id": "FBgn0032891", "name": "Oseg5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ72", "map_id": "Q9VJ72", "name": "IFT46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032692", "map_id": "FBgn0032692", "name": "IFT46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK41", "map_id": "Q9VK41", "name": "Ttc30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032470", "map_id": "FBgn0032470", "name": "Ttc30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VF41", "map_id": "Q9VF41", "name": "Ttc26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038358", "map_id": "FBgn0038358", "name": "Ttc26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR64", "map_id": "Q9VR64", "name": "Cluap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031196", "map_id": "FBgn0031196", "name": "Cluap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6F0", "map_id": "A1Z6F0", "name": "IFT20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050441", "map_id": "FBgn0050441", "name": "IFT20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474157", "map_id": "none", "name": "anterograde IFT trains", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "reaction_10474169", "map_id": "none", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10474167", "map_id": "none", "name": "retrograde IFT trains", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5263228", "compartment_display": "ciliary tip", "complex": "true" }, { "id": "species_10474163", "map_id": "none", "name": "retrograde IFT trains", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10473319", "map_id": "none", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10473317", "map_id": "none", "name": "IFT20:TRIP11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A0A4D6K5M0", "map_id": "A0A4D6K5M0", "name": "Gmap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027287", "map_id": "FBgn0027287", "name": "Gmap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473315", "map_id": "A0A4D6K5M0", "name": "Gmap", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10473310", "map_id": "A1Z6F0", "name": "IFT20", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10473908", "map_id": "none", "name": "TNPO1 binds KIF17 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473892", "map_id": "none", "name": "KIF17 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V4A1", "map_id": "Q9V4A1", "name": "Kif3C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039925", "map_id": "FBgn0039925", "name": "Kif3C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450986", "map_id": "Q9VRV8", "name": "Tnpo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0024921", "map_id": "FBgn0024921", "name": "Tnpo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473894", "map_id": "none", "name": "KIF17 dimer:TNPO1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VRV8", "map_id": "Q9VRV8", "name": "Tnpo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473904", "map_id": "none", "name": "KIF17 enters the cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_18730", "compartment_display": "cilium" }, { "id": "species_10473902", "map_id": "none", "name": "KIF17 dimer:TNPO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_18730", "compartment_display": "cilium", "complex": "true" }, { "id": "reaction_10458647", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458644", "map_id": "Q7KVW5", "name": "SK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0029761", "map_id": "FBgn0029761", "name": "SK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458658", "map_id": "none", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458655", "map_id": "none", "name": "Small conductance Ca2+ activated potassium channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7KVW5", "map_id": "Q7KVW5", "name": "SK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448363", "map_id": "none", "name": "Nonendonucleolytic RISC binds exactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426523", "map_id": "none", "name": "RNA (exact match)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448341", "map_id": "none", "name": "Nonendonucleolytic RISC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VUQ5", "map_id": "Q9VUQ5", "name": "AGO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0087035", "map_id": "FBgn0087035", "name": "AGO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10448348", "map_id": "Q8SY33", "name": "gw", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0051992", "map_id": "FBgn0051992", "name": "gw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10448361", "map_id": "none", "name": "TNRC6:Nonendonucleolytic RISC:Target RNA (exact match)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8SY33", "map_id": "Q8SY33", "name": "gw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10448359", "map_id": "none", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426511", "map_id": "none", "name": "Cleaved RNA with 5' Phosphate and 3' Hydroxyl", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448333", "map_id": "none", "name": "Endonucleolytic RISC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10448356", "map_id": "none", "name": "RISC binds inexactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448343", "map_id": "none", "name": "RISC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_426515", "map_id": "none", "name": "RNA (inexact match)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10448354", "map_id": "none", "name": "TNRC6:RISC:Target RNA (inexact match)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10448329", "map_id": "none", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_426463", "map_id": "none", "name": "Double-stranded RNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442303", "map_id": "none", "name": "TARBP2,PRKRA RLC", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10448326", "map_id": "none", "name": "TARBP2,PRKRA RLC:duplex siRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464903", "map_id": "none", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464891", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:Pre-RISC (siRNA)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496968", "map_id": "none", "name": "C3PO hydrolyzes cleaved passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496953", "map_id": "none", "name": "AGO2:cleaved duplex siRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10448331", "map_id": "none", "name": "AGO2:siRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10496965", "map_id": "none", "name": "C3PO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VF77", "map_id": "Q9VF77", "name": "Trax", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038327", "map_id": "FBgn0038327", "name": "Trax", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JVK6", "map_id": "Q7JVK6", "name": "trsn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033528", "map_id": "FBgn0033528", "name": "trsn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464901", "map_id": "none", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464899", "map_id": "none", "name": "TARBP2,PRKRA:DICER1:RISC (siRNA)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496971", "map_id": "none", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464877", "map_id": "none", "name": "AGO2:duplex siRNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10472623", "map_id": "none", "name": "Importin-8 binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10443060", "map_id": "none", "name": "AGO2:miRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10472619", "map_id": "Q9VSD6", "name": "msk", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0026252", "map_id": "FBgn0026252", "name": "msk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472621", "map_id": "none", "name": "IPO8:AGO2:miRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSD6", "map_id": "Q9VSD6", "name": "msk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472637", "map_id": "none", "name": "Importin-8 imports AGO2:miRNA into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472631", "map_id": "none", "name": "AGO2:miRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10472635", "map_id": "none", "name": "IPO8:RAN:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10472668", "map_id": "none", "name": "TNRC6A:AGO2:miRNA is transported into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10472660", "map_id": "none", "name": "TNRC6A:AGO2:miRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10472666", "map_id": "none", "name": "TNRC6A:AGO2:miRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10472662", "map_id": "none", "name": "TNRC6A binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10458332", "map_id": "none", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458319", "map_id": "none", "name": "p38 MAPK", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458329", "map_id": "none", "name": "Phospho-p38 MAPK", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10450887", "map_id": "O62602", "name": "phospho-lic", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433309", "map_id": "none", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433302", "map_id": "none", "name": "Editosome (ADAR2) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9NII1", "map_id": "Q9NII1", "name": "Adar", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026086", "map_id": "FBgn0026086", "name": "Adar", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_76230", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433306", "map_id": "none", "name": "A to I edited RNA:Editosome (ADAR2) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433300", "map_id": "none", "name": "ADAR2 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10465775", "map_id": "none", "name": "SOS mediated nucleotide exchange of RAS (SHC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10465772", "map_id": "none", "name": "p-5Y-LAT:p-SHC1:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209218", "map_id": "none", "name": "Phosphorylated DL/DIF dimer activates transcription", "reversible": "false", "notes": "In the nucleus, phosphorylated Dorsal/Dif (DL/DIF) homodimer binds to its target genes and activates transcription.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_214725", "map_id": "none", "name": "Phospho DL/DIF dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_209295", "map_id": "none", "name": "Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated Dorsal/Dif (DL/DIF) homodimer, now free from its cytoplasmic anchor, Cactus (CACT), is imported to the nucleus. Phosphorylation of the DL/DIF homodimer is important for its nuclear localisation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_214728", "map_id": "none", "name": "Phospho DL/DIF dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209072", "map_id": "none", "name": "PLL kinase binds to TL:MYD88:TUB 'signalling complex'", "reversible": "false", "notes": "The Ser/Thr kinase Pelle (PLL) binds to the death domain of Tube (TUB) in the 'signalling complex' at the plasma membrane. On binding to TUB, PLL is activated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206600", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P08953", "map_id": "P08953", "name": "TL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "TL", "map_id": "TL", "name": "TL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P48607", "map_id": "P48607", "name": "ProSPZ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "ProSPZ", "map_id": "ProSPZ", "name": "ProSPZ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22812", "map_id": "P22812", "name": "TUB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "TUB", "map_id": "TUB", "name": "TUB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K105", "map_id": "Q7K105", "name": "MYD88", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "MYD88", "map_id": "MYD88", "name": "MYD88", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_206070", "map_id": "Q05652", "name": "PLL", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206889", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:PLL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q05652", "map_id": "Q05652", "name": "Phospho PLL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho PLL", "map_id": "Phospho PLL", "name": "Phospho PLL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_214878", "map_id": "none", "name": "PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex'", "reversible": "false", "notes": "The Ser/Thr kinase Pelle (PLL) binds to the death domain of Tube (TUB) in the 'signalling complex' at the plasma membrane. On binding to TUB, PLL is activated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_214743", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:WEK dimer:MYD88:TUB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VJN5", "map_id": "Q9VJN5", "name": "WEK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "WEK", "map_id": "WEK", "name": "WEK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_214742", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:PLL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10436619", "map_id": "none", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10436615", "map_id": "Q9VID4", "name": "phospho-Mondo", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10436617", "map_id": "Q9VID4", "name": "phospho-Mondo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10436721", "map_id": "none", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10477549", "map_id": "none", "name": "PPT2 hydrolyses PALMCoA to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_5690537", "map_id": "CHEBI:15525", "name": "PALM-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_1678675", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_5690516", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10477546", "map_id": "Q9VKH6", "name": "Ppt2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0032358", "map_id": "FBgn0032358", "name": "Ppt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432490", "map_id": "none", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432487", "map_id": "none", "name": "FASN dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B7Z001", "map_id": "B7Z001", "name": "phospho-FASN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477738", "map_id": "none", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4085415", "map_id": "CHEBI:16518", "name": "Fe(2+)Cb5", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_4085425", "map_id": "CHEBI:18097", "name": "Fe(3+)Cb5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5690558", "map_id": "CHEBI:15534", "name": "OLE-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10477735", "map_id": "none", "name": "SCD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q7K4Y0", "map_id": "Q7K4Y0", "name": "Desat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086687", "map_id": "FBgn0086687", "name": "Desat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432425", "map_id": "none", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432422", "map_id": "Q7KSQ0", "name": "sea", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0037912", "map_id": "FBgn0037912", "name": "sea", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441352", "map_id": "none", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432436", "map_id": "A1Z784", "name": "ACC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441469", "map_id": "none", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441466", "map_id": "Q9VVT8", "name": "ACSL1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0036821", "map_id": "FBgn0036821", "name": "ACSL1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476157", "map_id": "none", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5676631", "map_id": "CHEBI:15456", "name": "VLC3HA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5676634", "map_id": "CHEBI:50998", "name": "2,3-TE-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10476154", "map_id": "none", "name": "PTPLs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VKD2", "map_id": "Q9VKD2", "name": "Hacd1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032394", "map_id": "FBgn0032394", "name": "Hacd1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453291", "map_id": "none", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548819", "map_id": "CHEBI:15514", "name": "AA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548816", "map_id": "CHEBI:63821", "name": "3ODCT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453288", "map_id": "none", "name": "ELOVL1,2,3,5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VV87", "map_id": "Q9VV87", "name": "Baldspot", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260960", "map_id": "FBgn0260960", "name": "Baldspot", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHX7", "map_id": "Q9VHX7", "name": "ELOVL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037534", "map_id": "FBgn0037534", "name": "ELOVL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6NN18", "map_id": "Q6NN18", "name": "CT42569", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034382", "map_id": "FBgn0034382", "name": "CT42569", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCY6", "map_id": "Q9VCY6", "name": "sit", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038986", "map_id": "FBgn0038986", "name": "sit", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH59", "map_id": "Q9VH59", "name": "Dmel\\CG8534", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037761", "map_id": "FBgn0037761", "name": "Dmel\\CG8534", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V3H4", "map_id": "Q4V3H4", "name": "Dmel\\CG9459", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037764", "map_id": "FBgn0037764", "name": "Dmel\\CG9459", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCY5", "map_id": "Q9VCY5", "name": "CG13844", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053110", "map_id": "FBgn0053110", "name": "CG13844", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH58", "map_id": "Q9VH58", "name": "eloF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037762", "map_id": "FBgn0037762", "name": "eloF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZBD2", "map_id": "A1ZBD2", "name": "Dmel\\CG17821", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034383", "map_id": "FBgn0034383", "name": "Dmel\\CG17821", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCT3", "map_id": "Q9VCT3", "name": "Dmel\\CG6660", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039030", "map_id": "FBgn0039030", "name": "Dmel\\CG6660", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH57", "map_id": "Q9VH57", "name": "Dmel\\CG16904", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037763", "map_id": "FBgn0037763", "name": "Dmel\\CG16904", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95T98", "map_id": "Q95T98", "name": "CG9798", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051523", "map_id": "FBgn0051523", "name": "CG9798", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH55", "map_id": "Q9VH55", "name": "CT26802", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037765", "map_id": "FBgn0037765", "name": "CT26802", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SXD1", "map_id": "Q8SXD1", "name": "CG12138", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050008", "map_id": "FBgn0050008", "name": "CG12138", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCZ0", "map_id": "Q9VCZ0", "name": "Dmel\\CG5326", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038983", "map_id": "FBgn0038983", "name": "Dmel\\CG5326", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IMY2", "map_id": "Q8IMY2", "name": "Dmel\\CG31141", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051141", "map_id": "FBgn0051141", "name": "Dmel\\CG31141", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCY7", "map_id": "Q9VCY7", "name": "bond", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260942", "map_id": "FBgn0260942", "name": "bond", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479066", "map_id": "none", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5695985", "map_id": "CHEBI:27283", "name": "VLCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5695971", "map_id": "CHEBI:61910", "name": "VLCFA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479063", "map_id": "none", "name": "ACSBG1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V3S9", "map_id": "Q9V3S9", "name": "bgm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027348", "map_id": "FBgn0027348", "name": "bgm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3U0", "map_id": "Q9V3U0", "name": "hll", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286723", "map_id": "FBgn0286723", "name": "hll", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479082", "map_id": "none", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696008", "map_id": "CHEBI:27283", "name": "VLCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696003", "map_id": "CHEBI:61910", "name": "VLCFA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10479079", "map_id": "Q7KVU5", "name": "Dmel\\CG18155", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0029945", "map_id": "FBgn0029945", "name": "Dmel\\CG18155", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453338", "map_id": "none", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548812", "map_id": "CHEBI:50571", "name": "3OOD-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548836", "map_id": "CHEBI:50583", "name": "3HODC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440266", "map_id": "Q9W3N1", "name": "spidey", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0029975", "map_id": "FBgn0029975", "name": "spidey", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453335", "map_id": "none", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548794", "map_id": "CHEBI:15527", "name": "ICS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_548829", "map_id": "CHEBI:52328", "name": "3ODC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453327", "map_id": "none", "name": "Homologues of ELOVL7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10453332", "map_id": "none", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10453329", "map_id": "none", "name": "ELOVL3,6,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10453348", "map_id": "none", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_548809", "map_id": "CHEBI:50570", "name": "TOD-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10453343", "map_id": "Q9VZL3", "name": "Sc2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0035471", "map_id": "FBgn0035471", "name": "Sc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436643", "map_id": "none", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10495309", "map_id": "none", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8957387", "map_id": "CHEBI:15456", "name": "3HA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8957386", "map_id": "CHEBI:50998", "name": "t2E-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10495306", "map_id": "Q9VEV6", "name": "Dmel\\CG14881", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0038425", "map_id": "FBgn0038425", "name": "Dmel\\CG14881", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432417", "map_id": "none", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432414", "map_id": "none", "name": "ACLY tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KN85", "map_id": "Q7KN85", "name": "ATPCL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020236", "map_id": "FBgn0020236", "name": "ATPCL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487694", "map_id": "none", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10487691", "map_id": "none", "name": "SCD5 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VG68", "map_id": "Q9VG68", "name": "Desat2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0043043", "map_id": "FBgn0043043", "name": "Desat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA93", "map_id": "Q9VA93", "name": "Dmel\\CG15531", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039755", "map_id": "FBgn0039755", "name": "Dmel\\CG15531", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTD4", "map_id": "Q9VTD4", "name": "Fad2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029172", "map_id": "FBgn0029172", "name": "Fad2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA94", "map_id": "Q9VA94", "name": "Dmel\\CG9747", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039754", "map_id": "FBgn0039754", "name": "Dmel\\CG9747", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFX5", "map_id": "Q9VFX5", "name": "Dmel\\CG8630", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038130", "map_id": "FBgn0038130", "name": "Dmel\\CG8630", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA92", "map_id": "Q9VA92", "name": "anon-WO0118547.264", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039756", "map_id": "FBgn0039756", "name": "anon-WO0118547.264", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477728", "map_id": "none", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_5690533", "map_id": "none", "name": "PALM:protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_6785219", "map_id": "CHEBI:36080", "name": "protein", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10477725", "map_id": "Q9W3C7", "name": "Ppt1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0030057", "map_id": "FBgn0030057", "name": "Ppt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495043", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10495031", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q9W0D7", "map_id": "Q9W0D7", "name": "Pex10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035233", "map_id": "FBgn0035233", "name": "Pex10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPT5", "map_id": "Q9VPT5", "name": "Pex12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031282", "map_id": "FBgn0031282", "name": "Pex12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46085", "map_id": "O46085", "name": "Pex5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023516", "map_id": "FBgn0023516", "name": "Pex5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JRD4", "map_id": "Q7JRD4", "name": "Pex13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033812", "map_id": "FBgn0033812", "name": "Pex13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPB8", "map_id": "Q9VPB8", "name": "Pex14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037020", "map_id": "FBgn0037020", "name": "Pex14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495040", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10495033", "map_id": "none", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10495029", "map_id": "none", "name": "Ub:UBE2D1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10495027", "map_id": "none", "name": "PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10493243", "map_id": "none", "name": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434753", "map_id": "none", "name": "PAF1C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9XZ19", "map_id": "Q9XZ19", "name": "Dmel\\CG3909", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027524", "map_id": "FBgn0027524", "name": "Dmel\\CG3909", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K0X3", "map_id": "Q7K0X3", "name": "Ctr9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035205", "map_id": "FBgn0035205", "name": "Ctr9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W261", "map_id": "Q9W261", "name": "Rtf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034722", "map_id": "FBgn0034722", "name": "Rtf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VN55", "map_id": "Q9VN55", "name": "atms", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010750", "map_id": "FBgn0010750", "name": "atms", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467826", "map_id": "P02283", "name": "His2B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0001198", "map_id": "FBgn0001198", "name": "His2B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493239", "map_id": "none", "name": "Ub:UBE2A,B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P25153", "map_id": "P25153", "name": "Ubc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004436", "map_id": "FBgn0004436", "name": "Ubc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493237", "map_id": "Q9VX88", "name": "wcy", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0030812", "map_id": "FBgn0030812", "name": "wcy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493232", "map_id": "none", "name": "RNF20:RNF40", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VRP9", "map_id": "Q9VRP9", "name": "Bre1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086694", "map_id": "FBgn0086694", "name": "Bre1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493241", "map_id": "none", "name": "PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VX88", "map_id": "Q9VX88", "name": "wcy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02283", "map_id": "P02283", "name": "His2B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493246", "map_id": "none", "name": "RNF20:RNF40 monoubiquitinates Histone H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10488716", "map_id": "P25153", "name": "Ubc6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10477560", "map_id": "P02283", "name": "His2B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433263", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433237", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433259", "map_id": "none", "name": "U7 snRNP:ZNF473", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A1Z802", "map_id": "A1Z802", "name": "Lsm11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033450", "map_id": "FBgn0033450", "name": "Lsm11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8C4", "map_id": "A1Z8C4", "name": "Lsm10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033554", "map_id": "FBgn0033554", "name": "Lsm10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10433261", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433239", "map_id": "none", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433235", "map_id": "Q9VAN6", "name": "Slbp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433230", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433267", "map_id": "none", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10436095", "map_id": "none", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449229", "map_id": "CHEBI:15809", "name": "DOLP-Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855667", "map_id": "CHEBI:53058", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855656", "map_id": "CHEBI:53059", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_162872", "map_id": "CHEBI:16214", "name": "dolichyl phosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10436092", "map_id": "Q9VZM5", "name": "PIG-B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0035464", "map_id": "FBgn0035464", "name": "PIG-B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436079", "map_id": "none", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855664", "map_id": "none", "name": "mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10436076", "map_id": "Q8MT80", "name": "PIG-Z", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0266438", "map_id": "FBgn0266438", "name": "PIG-Z", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436056", "map_id": "none", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8855657", "map_id": "CHEBI:15935", "name": "N-acetylglucosaminyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10436053", "map_id": "none", "name": "GPI-GnT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q7JUM3", "map_id": "Q7JUM3", "name": "PIG-A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034270", "map_id": "FBgn0034270", "name": "PIG-A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MSE4", "map_id": "Q8MSE4", "name": "PIG-P", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039405", "map_id": "FBgn0039405", "name": "PIG-P", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHX6", "map_id": "Q9VHX6", "name": "PIG-H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037535", "map_id": "FBgn0037535", "name": "PIG-H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A2U8U156", "map_id": "A0A2U8U156", "name": "PIG-C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035435", "map_id": "FBgn0035435", "name": "PIG-C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IR17", "map_id": "Q8IR17", "name": "PIG-Q", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086448", "map_id": "FBgn0086448", "name": "PIG-Q", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436087", "map_id": "none", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855659", "map_id": "CHEBI:53056", "name": "mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500581", "map_id": "CHEBI:16038", "name": "PE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855663", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10436084", "map_id": "A1Z838", "name": "PIG-N", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0033479", "map_id": "FBgn0033479", "name": "PIG-N", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436103", "map_id": "none", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10436100", "map_id": "Q9V7W1", "name": "PIG-V", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0265174", "map_id": "FBgn0265174", "name": "PIG-V", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436071", "map_id": "none", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8855660", "map_id": "CHEBI:77364", "name": "(ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10436068", "map_id": "none", "name": "PIGF:PIGG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VW21", "map_id": "Q9VW21", "name": "PIG-F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036893", "map_id": "FBgn0036893", "name": "PIG-F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z705", "map_id": "A1Z705", "name": "PIG-G", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033187", "map_id": "FBgn0033187", "name": "PIG-G", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436004", "map_id": "none", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_75967", "map_id": "CHEBI:37554", "name": "FACoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8855661", "map_id": "CHEBI:24275", "name": "glucosaminyl-PI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8855666", "map_id": "CHEBI:52572", "name": "glucosaminyl-acyl-PI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10436001", "map_id": "Q9W096", "name": "PIG-Wb", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0035265", "map_id": "FBgn0035265", "name": "PIG-Wb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467548", "map_id": "none", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467524", "map_id": "Q8SWT2", "name": "Rhau", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0032883", "map_id": "FBgn0032883", "name": "Rhau", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_3134861", "map_id": "none", "name": "Unmethylated CpG DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467526", "map_id": "none", "name": "DHX36:CpG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8SWT2", "map_id": "Q8SWT2", "name": "Rhau", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497380", "map_id": "none", "name": "NFkB complex translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467540", "map_id": "none", "name": "DHX9:CpG:MyD88", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10467546", "map_id": "none", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467528", "map_id": "P24785", "name": "mle", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467530", "map_id": "none", "name": "DHX9:CpG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10467544", "map_id": "none", "name": "DHX36 or DHX9 binds MyD88", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467536", "map_id": "Q7K105", "name": "Myd88", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467532", "map_id": "none", "name": "DHX9/DHX36:CpG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10467542", "map_id": "none", "name": "DHX9/DHX36:CpG:MyD88", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209187", "map_id": "none", "name": "Further phosphorylation of CI by CKIalphaepsilon", "reversible": "false", "notes": "Previous phosphorylation of Cubitus Interruptus (CI) at Ser852 and Ser888 primes further phosphorylation by CKIalphaepsilon (CKIalpha/DCO) at Ser855, Ser858, and Ser891.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206997", "map_id": "none", "name": "COS:Phospho (13 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206577", "map_id": "none", "name": "CKIalphaepsilon", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209172", "map_id": "none", "name": "Phosphorylation of CI by SGG", "reversible": "false", "notes": "Previous phosphorylation of Cubitus Interruptus (CI) at Ser856 and Ser892 primes Shaggy (SGG) phosphorylation at Ser884 and Ser888. Ser852 can also be phosphorylated by SGG if it hasn't been previously phosphorylated by CKIalpha/DCO.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206924", "map_id": "none", "name": "COS:Phospho (11 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209293", "map_id": "none", "name": "Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO)", "reversible": "false", "notes": "The priming phosphorylations of Cubitus Interruptus (CI) results in additional phosphorylation by kinases CKIalphaepsilon (CKIalpha/DCO) at Ser841, Ser844, Thr845, Ser849, Ser852, Ser859, Ser862, and Ser895.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206916", "map_id": "none", "name": "COS:Phospho (3 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209196", "map_id": "none", "name": "Phosphorylation of CI by PKA-C1", "reversible": "false", "notes": "Cubitus Interruptus (CI) is primed for phosphorylation by Protein kinase A (PKA-C1) at Ser838, Ser856, and Ser892.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206721", "map_id": "none", "name": "COS:CI:FU:PKA-C1:SGG:CKIalpha:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206865", "map_id": "none", "name": "CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457576", "map_id": "none", "name": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10454153", "map_id": "none", "name": "IFNG-activated factor (GAF)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10457569", "map_id": "Q24151", "name": "Stat92E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10457573", "map_id": "Q9W0G1-2", "name": "Ptp61F", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10448751", "map_id": "none", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448746", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein G13 (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10448748", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein G13 (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10448722", "map_id": "none", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448717", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein Gq (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10448719", "map_id": "none", "name": "TP receptor:Thromboxane A2:G-protein Gq (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446811", "map_id": "none", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446806", "map_id": "none", "name": "ADP:P2RY12:G-protein Gi (inactive)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446808", "map_id": "none", "name": "ADP:P2RY12:G-protein Gi (active)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10448755", "map_id": "none", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448753", "map_id": "O61443", "name": "p38b", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439430", "map_id": "O61443", "name": "phospho-p38b", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10447584", "map_id": "none", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447582", "map_id": "P00528", "name": "phospho-Src64B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433304", "map_id": "none", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_75086", "map_id": "none", "name": "dsRNA duplex", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434102", "map_id": "none", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433298", "map_id": "Q9NII1", "name": "Adar", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10455818", "map_id": "none", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_975819", "map_id": "CHEBI:60615", "name": "(GlcNAc)3 (Man)3 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_975822", "map_id": "CHEBI:60651", "name": "(GlcNAc)4 (Man)3 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10455815", "map_id": "Q961U0", "name": "Mgat2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0039738", "map_id": "FBgn0039738", "name": "Mgat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479784", "map_id": "none", "name": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_6786371", "map_id": "CHEBI:86336", "name": "HNK1 carbohydrate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_6786380", "map_id": "CHEBI:86335", "name": "S-HNK1 carbohydrate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10479781", "map_id": "none", "name": "Homologues of CHST10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q8IRG5", "map_id": "Q8IRG5", "name": "d4ST2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035287", "map_id": "FBgn0035287", "name": "d4ST2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMS3", "map_id": "Q9VMS3", "name": "d4ST1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031697", "map_id": "FBgn0031697", "name": "d4ST1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJG5", "map_id": "Q9VJG5", "name": "CG4826", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032618", "map_id": "FBgn0032618", "name": "CG4826", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457715", "map_id": "none", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_205689", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_1028779", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10457712", "map_id": "Q9VYV5", "name": "FucT6", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0030327", "map_id": "FBgn0030327", "name": "FucT6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478179", "map_id": "none", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_6784247", "map_id": "none", "name": "NGP:1,6-GlcNAc", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784248", "map_id": "CHEBI:59520", "name": "NGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6784249", "map_id": "CHEBI:2181", "name": "L-fucose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10478176", "map_id": "none", "name": "FUCA1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9VTJ4", "map_id": "Q9VTJ4", "name": "Fuca", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0285958", "map_id": "FBgn0285958", "name": "Fuca", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455810", "map_id": "none", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_964837", "map_id": "CHEBI:60625", "name": "(GlcNAc)3 (Man)5 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10455807", "map_id": "none", "name": "MAN2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VF33", "map_id": "Q9VF33", "name": "alpha-Man-IIb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026616", "map_id": "FBgn0026616", "name": "alpha-Man-IIb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24451", "map_id": "Q24451", "name": "alpha-Man-IIa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011740", "map_id": "FBgn0011740", "name": "alpha-Man-IIa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455908", "map_id": "none", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_981613", "map_id": "none", "name": "Glycoprotein with bifurcating GlcNAc in position 3", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10455905", "map_id": "Q95RF3", "name": "Mgat3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0051849", "map_id": "FBgn0051849", "name": "Mgat3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440636", "map_id": "none", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193103", "map_id": "CHEBI:16581", "name": "PREG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196344", "map_id": "CHEBI:63837", "name": "pregn-5-ene-3,20-dione", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440205", "map_id": "none", "name": "HSD2B1 dimer, HSD3B2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VVE3", "map_id": "Q9VVE3", "name": "Dmel\\CG7724", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440208", "map_id": "none", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193055", "map_id": "CHEBI:17026", "name": "P4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10493825", "map_id": "none", "name": "CCND1 binds RUNX3 and displaces EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10493737", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:EP300:BRD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VCG6", "map_id": "Q9VCG6", "name": "tbrd-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039124", "map_id": "FBgn0039124", "name": "tbrd-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13709", "map_id": "P13709", "name": "fs(1)h", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004656", "map_id": "FBgn0004656", "name": "fs(1)h", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457979", "map_id": "Q7KUZ5", "name": "CycD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10493823", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493829", "map_id": "none", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10493827", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9PHQ2", "map_id": "M9PHQ2", "name": "HDAC4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493721", "map_id": "none", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10493708", "map_id": "none", "name": "RUNX3:CBFB:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10493718", "map_id": "none", "name": "Ac-K94,K171-RUNX3:CBFB:EP300", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493834", "map_id": "none", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_427486", "map_id": "CHEBI:15366", "name": "CH3COO-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10493735", "map_id": "none", "name": "BRD2 homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10493831", "map_id": "none", "name": "RUNX3:CBFB:CCND1:HDAC4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493739", "map_id": "none", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10493710", "map_id": "none", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489803", "map_id": "none", "name": "RUNX3:CBFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10449032", "map_id": "none", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429926", "map_id": "none", "name": "capped oligoribonucleotide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_430042", "map_id": "CHEBI:17825", "name": "7MGMP", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_429925", "map_id": "none", "name": "oligoribonucleotide with a 5'-diphosphate", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449029", "map_id": "Q9VNH5", "name": "Dmel\\CG2091", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0037372", "map_id": "FBgn0037372", "name": "Dmel\\CG2091", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478392", "map_id": "none", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694090", "map_id": "CHEBI:20794", "name": "7MG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10478389", "map_id": "Q9W197", "name": "cN-IIIB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0034988", "map_id": "FBgn0034988", "name": "cN-IIIB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449126", "map_id": "none", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_429974", "map_id": "none", "name": "mature mRNA (eukaryotic, capped and deadenylated)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449123", "map_id": "none", "name": "Exosome:SKI complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VC93", "map_id": "Q9VC93", "name": "Dis3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039183", "map_id": "FBgn0039183", "name": "Dis3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6NNB2", "map_id": "Q6NNB2", "name": "SKI3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033376", "map_id": "FBgn0033376", "name": "SKI3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCH8", "map_id": "Q9VCH8", "name": "tst", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039117", "map_id": "FBgn0039117", "name": "tst", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W074", "map_id": "Q9W074", "name": "HBS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042712", "map_id": "FBgn0042712", "name": "HBS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10492020", "map_id": "none", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491997", "map_id": "none", "name": "RUNX1:CBFB:PRMT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492017", "map_id": "none", "name": "MeR206,MeR210-RUNX1:CBFB:PRMT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492022", "map_id": "none", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10492150", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492130", "map_id": "none", "name": "H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VPQ6", "map_id": "Q9VPQ6", "name": "ush", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003963", "map_id": "FBgn0003963", "name": "ush", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3J8", "map_id": "Q9V3J8", "name": "wds", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040066", "map_id": "FBgn0040066", "name": "wds", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20659", "map_id": "P20659", "name": "trx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003862", "map_id": "FBgn0003862", "name": "trx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5LJZ2", "map_id": "Q5LJZ2", "name": "Set1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040022", "map_id": "FBgn0040022", "name": "Set1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUB5", "map_id": "Q9VUB5", "name": "upSET", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036398", "map_id": "FBgn0036398", "name": "upSET", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1H0", "map_id": "Q9W1H0", "name": "Lpt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263667", "map_id": "FBgn0263667", "name": "Lpt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZJ1", "map_id": "Q9VZJ1", "name": "Dpy-30L2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035491", "map_id": "FBgn0035491", "name": "Dpy-30L2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0HL66", "map_id": "C0HL66", "name": "His3.3A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014857", "map_id": "FBgn0014857", "name": "His3.3A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C0HL67", "map_id": "C0HL67", "name": "His3.3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004828", "map_id": "FBgn0004828", "name": "His3.3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02299", "map_id": "P02299", "name": "His3:CG33845", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001199", "map_id": "FBgn0001199", "name": "His3:CG33845", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10492147", "map_id": "none", "name": "H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492198", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492193", "map_id": "none", "name": "H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492195", "map_id": "none", "name": "H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492189", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492184", "map_id": "none", "name": "H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492186", "map_id": "none", "name": "H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492159", "map_id": "none", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492154", "map_id": "none", "name": "H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492156", "map_id": "none", "name": "H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468106", "map_id": "none", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468104", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10468092", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10468102", "map_id": "none", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468094", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10468100", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468098", "map_id": "none", "name": "p-S407,Y641-STAT6 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10430845", "map_id": "none", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430513", "map_id": "Q9VXK6", "name": "eIF5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030719", "map_id": "FBgn0030719", "name": "eIF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_72617", "map_id": "none", "name": "eIF1", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10430519", "map_id": "none", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10464559", "map_id": "none", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10464550", "map_id": "Q9VTZ1", "name": "Gcn5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10464555", "map_id": "Q9W3F4", "name": "org-1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0021767", "map_id": "FBgn0021767", "name": "org-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10464557", "map_id": "none", "name": "TBX5:WWTR1:PCAF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W3F4", "map_id": "Q9W3F4", "name": "org-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490929", "map_id": "none", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10464537", "map_id": "P30052", "name": "sd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10490927", "map_id": "none", "name": "TEAD2:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P30052", "map_id": "P30052", "name": "sd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "sd", "map_id": "sd", "name": "sd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490933", "map_id": "none", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10464541", "map_id": "P30052", "name": "sd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10490931", "map_id": "none", "name": "TEAD4:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10464535", "map_id": "none", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10464531", "map_id": "P30052", "name": "sd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10464533", "map_id": "none", "name": "TEAD1:YAP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10490937", "map_id": "none", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10464539", "map_id": "P30052", "name": "sd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10490935", "map_id": "none", "name": "TEAD3:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10464545", "map_id": "none", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10464543", "map_id": "none", "name": "TEAD:WWTR1(TAZ)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10440633", "map_id": "none", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196095", "map_id": "CHEBI:17998", "name": "ISCAL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196066", "map_id": "CHEBI:63910", "name": "MePeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440630", "map_id": "M9PF61", "name": "Akr1B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433192", "map_id": "none", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77313", "map_id": "CHEBI:15473", "name": "Crotonoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77251", "map_id": "CHEBI:15453", "name": "3HB-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433202", "map_id": "none", "name": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77318", "map_id": "CHEBI:15517", "name": "BT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10433199", "map_id": "none", "name": "ACADS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VDT1", "map_id": "Q9VDT1", "name": "Arc42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038742", "map_id": "FBgn0038742", "name": "Arc42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10435438", "map_id": "none", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141349", "map_id": "CHEBI:17927", "name": "NASPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_141327", "map_id": "CHEBI:30322", "name": "3AAPNAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_141350", "map_id": "CHEBI:17148", "name": "PTCN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10435435", "map_id": "none", "name": "PAOX:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q9VHN8", "map_id": "Q9VHN8", "name": "Dmel\\CG8032", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037606", "map_id": "FBgn0037606", "name": "Dmel\\CG8032", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10435428", "map_id": "none", "name": "SMOX-3 oxidises SPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141328", "map_id": "CHEBI:18090", "name": "3APAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10435425", "map_id": "Q9VVK1", "name": "Dmel\\CG7460", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036749", "map_id": "FBgn0036749", "name": "Dmel\\CG7460", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444066", "map_id": "none", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_204635", "map_id": "CHEBI:16610", "name": "SPM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_353555", "map_id": "CHEBI:17927", "name": "NASPM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444061", "map_id": "Q8MRT7", "name": "BcDNA:SD26038", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0038302", "map_id": "FBgn0038302", "name": "BcDNA:SD26038", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444064", "map_id": "none", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353560", "map_id": "CHEBI:15746", "name": "SPN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_353575", "map_id": "CHEBI:17312", "name": "NASPN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10435440", "map_id": "none", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_141323", "map_id": "CHEBI:17312", "name": "NASPN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10454399", "map_id": "none", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29970", "map_id": "CHEBI:16946", "name": "L-KYN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_893615", "map_id": "CHEBI:17442", "name": "AP-DOBu", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10454393", "map_id": "none", "name": "PXLP-KYAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8SXC2", "map_id": "Q8SXC2", "name": "Kyat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037955", "map_id": "FBgn0037955", "name": "Kyat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8939576", "map_id": "none", "name": "I3LACT, I3PROPA", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:55528", "map_id": "CHEBI:55528", "name": "CHEBI:55528", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:43580", "map_id": "CHEBI:43580", "name": "CHEBI:43580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490481", "map_id": "none", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_352006", "map_id": "CHEBI:57912", "name": "L-Trp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10428730", "map_id": "none", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_33179", "map_id": "CHEBI:18377", "name": "NFK", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428727", "map_id": "none", "name": "TDO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P20351", "map_id": "P20351", "name": "v", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003965", "map_id": "FBgn0003965", "name": "v", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428738", "map_id": "none", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_34351", "map_id": "CHEBI:17380", "name": "3HKYN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428735", "map_id": "A1Z746", "name": "cn", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0000337", "map_id": "FBgn0000337", "name": "cn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10426991", "map_id": "none", "name": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10426958", "map_id": "none", "name": "Cdt1:geminin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10426956", "map_id": "Q7JVY2", "name": "dup", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426989", "map_id": "none", "name": "geminin:ubiquitin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10427212", "map_id": "none", "name": "Free CDT1 associates with CDC6:ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426944", "map_id": "none", "name": "CDC6:ORC:origin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10427210", "map_id": "none", "name": "CDT1:CDC6:ORC:origin complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10427206", "map_id": "none", "name": "Ubiquitinated geminin is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10491189", "map_id": "none", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_29480", "map_id": "CHEBI:58937", "name": "ThDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10491186", "map_id": "Q7K0L7", "name": "Tpc1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0037852", "map_id": "FBgn0037852", "name": "Tpc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441188", "map_id": "none", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_199622", "map_id": "CHEBI:18385", "name": "THMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_196934", "map_id": "CHEBI:18385", "name": "THMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441185", "map_id": "none", "name": "SLC19A2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VGV5", "map_id": "Q9VGV5", "name": "Dmel\\CG6574", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037846", "map_id": "FBgn0037846", "name": "Dmel\\CG6574", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK64", "map_id": "Q9VK64", "name": "Dmel\\CG17036", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032449", "map_id": "FBgn0032449", "name": "Dmel\\CG17036", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGV6", "map_id": "Q9VGV6", "name": "Dmel\\CG14694", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037845", "map_id": "FBgn0037845", "name": "Dmel\\CG14694", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440656", "map_id": "none", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440653", "map_id": "none", "name": "2xTPK1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8T4A5", "map_id": "Q8T4A5", "name": "Dmel\\CG14721", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037942", "map_id": "FBgn0037942", "name": "Dmel\\CG14721", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440685", "map_id": "none", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73524", "map_id": "CHEBI:17621", "name": "FMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_29386", "map_id": "CHEBI:16238", "name": "FAD", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440682", "map_id": "Q9VYI5", "name": "Dmel\\CG4407", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030431", "map_id": "FBgn0030431", "name": "Dmel\\CG4407", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467560", "map_id": "none", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3165253", "map_id": "CHEBI:17015", "name": "RIB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_196931", "map_id": "CHEBI:17015", "name": "RIB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467553", "map_id": "Q9V9S9", "name": "Rift", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0039882", "map_id": "FBgn0039882", "name": "Rift", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440695", "map_id": "none", "name": "RFK:Mg2+ phosphorylates RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440692", "map_id": "none", "name": "RFK:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O76206", "map_id": "O76206", "name": "anon-84Ea", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014930", "map_id": "FBgn0014930", "name": "anon-84Ea", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455535", "map_id": "none", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965053", "map_id": "CHEBI:16709", "name": "PDX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_964952", "map_id": "CHEBI:28803", "name": "PDXP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10455530", "map_id": "none", "name": "2xPDXK:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KUC2", "map_id": "Q7KUC2", "name": "Pdxk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085484", "map_id": "FBgn0085484", "name": "Pdxk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455533", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_964945", "map_id": "CHEBI:16410", "name": "PXA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_965146", "map_id": "CHEBI:18335", "name": "PXAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10455549", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29390", "map_id": "CHEBI:18405", "name": "PXLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10455544", "map_id": "none", "name": "2xPNPO:2xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VHZ5", "map_id": "Q9VHZ5", "name": "sgll", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051472", "map_id": "FBgn0051472", "name": "sgll", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455547", "map_id": "none", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10467575", "map_id": "none", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_965131", "map_id": "CHEBI:17310", "name": "PXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_3204324", "map_id": "CHEBI:17405", "name": "PDXate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467572", "map_id": "none", "name": "2xAOX1:cofactors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:33722", "map_id": "CHEBI:33722", "name": "CHEBI:33722", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455537", "map_id": "none", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10467320", "map_id": "none", "name": "CUBN:AMN binds GIF:Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10467316", "map_id": "none", "name": "GIF:Cbl", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_3000239", "map_id": "CHEBI:28911", "name": "Cbl", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q9W4K2", "map_id": "Q9W4K2", "name": "TCN1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029708", "map_id": "FBgn0029708", "name": "TCN1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10443525", "map_id": "none", "name": "CUBN:AMN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A8JQY3", "map_id": "A8JQY3", "name": "CG4940", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085431", "map_id": "FBgn0085431", "name": "CG4940", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPN2", "map_id": "Q9VPN2", "name": "Amnionless", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025686", "map_id": "FBgn0025686", "name": "Amnionless", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467318", "map_id": "none", "name": "CUBN:AMN:GIF:Cbl", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10467416", "map_id": "none", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_3000241", "map_id": "CHEBI:28911", "name": "Cbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_3000125", "map_id": "CHEBI:28911", "name": "Cbl", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10443830", "map_id": "Q7KTC0", "name": "MRP", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10467352", "map_id": "none", "name": "TCII:Cbl is degraded to release Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10467328", "map_id": "none", "name": "TCII:Cbl", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10467350", "map_id": "none", "name": "Endosomal GIF:Cbl translocates to lysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "species_10467342", "map_id": "none", "name": "GIF:Cbl", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17940", "compartment_display": "endosome", "complex": "true" }, { "id": "species_10467348", "map_id": "none", "name": "GIF:Cbl", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10467332", "map_id": "none", "name": "GIF binds Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10467314", "map_id": "Q9W4K2", "name": "GIF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10467507", "map_id": "none", "name": "TCN1 binds Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_3132775", "map_id": "none", "name": "Food proteins:Cbl", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10467503", "map_id": "Q9W4K2", "name": "TCN1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10467505", "map_id": "none", "name": "TCN1:Cbl", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_3132772", "map_id": "none", "name": "Food proteins", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10467891", "map_id": "none", "name": "TCN1 binds Cbl in the circulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10467330", "map_id": "none", "name": "Endosomal TCII:Cbl translocates to lysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17940", "compartment_display": "endosome" }, { "id": "species_10467324", "map_id": "none", "name": "TCII:Cbl", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17940", "compartment_display": "endosome", "complex": "true" }, { "id": "reaction_10467344", "map_id": "none", "name": "CUBN:AMN transports extracellular GIF:Cbl to endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10467338", "map_id": "none", "name": "CUBN:AMN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10467312", "map_id": "none", "name": "TCII binds Cbl in the circulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10467308", "map_id": "Q9W4K2", "name": "TCII", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10467310", "map_id": "none", "name": "TCII:Cbl", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10440735", "map_id": "none", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197256", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440732", "map_id": "none", "name": "NADSYN1 hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VYA0", "map_id": "Q9VYA0", "name": "Nadsyn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030512", "map_id": "FBgn0030512", "name": "Nadsyn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441342", "map_id": "none", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8938083", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8938078", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_8938090", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10441339", "map_id": "none", "name": "4xNMNAT3:4xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VC03", "map_id": "Q9VC03", "name": "Nmnat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039254", "map_id": "FBgn0039254", "name": "Nmnat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490435", "map_id": "none", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869365", "map_id": "CHEBI:58527", "name": "NAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_197220", "map_id": "CHEBI:15763", "name": "NAMN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10490432", "map_id": "Q9VZR0", "name": "Dmel\\CG12016", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035436", "map_id": "FBgn0035436", "name": "Dmel\\CG12016", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490440", "map_id": "none", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10490437", "map_id": "Q9VZR0", "name": "Dmel\\CG12016", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440725", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1132084", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440722", "map_id": "none", "name": "NMNAT2:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10490443", "map_id": "none", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8869377", "map_id": "CHEBI:15927", "name": "NR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8869353", "map_id": "CHEBI:14649", "name": "NMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10492619", "map_id": "none", "name": "NT5E:Zn2+ hydrolyses NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352330", "map_id": "CHEBI:57540", "name": "NAD+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8940067", "map_id": "CHEBI:14649", "name": "NMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10492621", "map_id": "none", "name": "NT5E:Zn2+ hydrolyses NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8940077", "map_id": "CHEBI:15927", "name": "NRNAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10490446", "map_id": "none", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10440715", "map_id": "none", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440712", "map_id": "none", "name": "NADK:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q6IDH2", "map_id": "Q6IDH2", "name": "CT19307", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033853", "map_id": "FBgn0033853", "name": "CT19307", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10492564", "map_id": "none", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10486272", "map_id": "none", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807477", "map_id": "CHEBI:64084", "name": "S-NADPHX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10486269", "map_id": "Q9VVW8", "name": "Naxd", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0036848", "map_id": "FBgn0036848", "name": "Naxd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10492311", "map_id": "none", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8938276", "map_id": "CHEBI:133202", "name": "(ADP-D-ribosyl)(n)-acceptor", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8938282", "map_id": "CHEBI:133203", "name": "(ADP-D-ribosyl)(n+1)-acceptor", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10492304", "map_id": "A1ZAG4", "name": "Parp16", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0034129", "map_id": "FBgn0034129", "name": "Parp16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486264", "map_id": "none", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807473", "map_id": "CHEBI:64085", "name": "R-NADPHX", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10486261", "map_id": "none", "name": "APOA1BP dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9W2Y3", "map_id": "Q9W2Y3", "name": "Naxe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030178", "map_id": "FBgn0030178", "name": "Naxe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490427", "map_id": "none", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490424", "map_id": "Q95R48", "name": "Orct2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10440705", "map_id": "none", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440702", "map_id": "none", "name": "NAPRT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VQX4", "map_id": "Q9VQX4", "name": "Naprt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031589", "map_id": "FBgn0031589", "name": "Naprt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441349", "map_id": "none", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_200492", "map_id": "CHEBI:15763", "name": "NAMN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8878981", "map_id": "CHEBI:33019", "name": "PPi(3-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_200499", "map_id": "CHEBI:18304", "name": "NAAD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10441346", "map_id": "none", "name": "6xNMNAT1:6xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10440974", "map_id": "none", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_198852", "map_id": "CHEBI:58539", "name": "DeHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_198827", "map_id": "CHEBI:58539", "name": "DeHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440971", "map_id": "none", "name": "SLC2A1,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10441014", "map_id": "none", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497805", "map_id": "CHEBI:59513", "name": "Asc.-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441000", "map_id": "none", "name": "CYB5A:heme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9VJC0", "map_id": "Q9VJC0", "name": "Dmel\\CG6870", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032652", "map_id": "FBgn0032652", "name": "Dmel\\CG6870", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4N3", "map_id": "Q9V4N3", "name": "Cyt-b5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264294", "map_id": "FBgn0264294", "name": "Cyt-b5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRR0", "map_id": "Q8IRR0", "name": "Dmel\\CG3566", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029854", "map_id": "FBgn0029854", "name": "Dmel\\CG3566", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUZ3", "map_id": "Q9VUZ3", "name": "Dmel\\CG5157", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036575", "map_id": "FBgn0036575", "name": "Dmel\\CG5157", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10440998", "map_id": "none", "name": "CYB5A:ferriheme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "CHEBI:36144", "map_id": "CHEBI:36144", "name": "CHEBI:36144", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_198816", "map_id": "CHEBI:38290", "name": "AscH-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441011", "map_id": "none", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441008", "map_id": "none", "name": "CYB5R3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "X2JGK6", "map_id": "X2JGK6", "name": "Dmel\\CG5946", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036211", "map_id": "FBgn0036211", "name": "Dmel\\CG5946", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440945", "map_id": "none", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440942", "map_id": "none", "name": "GSTO dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSL6", "map_id": "Q9VSL6", "name": "GstO1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035907", "map_id": "FBgn0035907", "name": "GstO1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSL5", "map_id": "Q9VSL5", "name": "GstO2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035906", "map_id": "FBgn0035906", "name": "GstO2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSL3", "map_id": "Q9VSL3", "name": "se", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086348", "map_id": "FBgn0086348", "name": "se", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSL2", "map_id": "Q9VSL2", "name": "GstO3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035904", "map_id": "FBgn0035904", "name": "GstO3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441024", "map_id": "none", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_198836", "map_id": "CHEBI:38290", "name": "AscH-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10441019", "map_id": "Q9VH02", "name": "Dmel\\CG6293", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0037807", "map_id": "FBgn0037807", "name": "Dmel\\CG6293", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441433", "map_id": "none", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200739", "map_id": "CHEBI:60473", "name": "5,10-methylene-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_174404", "map_id": "CHEBI:63907", "name": "5-methyl-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441430", "map_id": "none", "name": "MTHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VTI0", "map_id": "Q9VTI0", "name": "Dmel\\CG7560", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036157", "map_id": "FBgn0036157", "name": "Dmel\\CG7560", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441362", "map_id": "none", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_200640", "map_id": "CHEBI:65049", "name": "5,10-methenyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441359", "map_id": "none", "name": "MTHFD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O96553", "map_id": "O96553", "name": "pug", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020385", "map_id": "FBgn0020385", "name": "pug", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486575", "map_id": "none", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6808499", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_200679", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29376", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10486572", "map_id": "none", "name": "ADH1L2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VIC9", "map_id": "Q9VIC9", "name": "phospho-Dmel\\CG8665", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032945", "map_id": "FBgn0032945", "name": "phospho-Dmel\\CG8665", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441423", "map_id": "none", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111353", "map_id": "CHEBI:28010", "name": "10-formyl-THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441420", "map_id": "none", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_200709", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_200665", "map_id": "CHEBI:15641", "name": "5-methyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441417", "map_id": "none", "name": "Homologues of SLC19A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10479244", "map_id": "none", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6801451", "map_id": "CHEBI:30751", "name": "HCOOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_200671", "map_id": "CHEBI:15635", "name": "THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5389850", "map_id": "CHEBI:15637", "name": "10-formyl-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10479241", "map_id": "none", "name": "MTHFD1L dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10486583", "map_id": "none", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_197969", "map_id": "CHEBI:28624", "name": "THFPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486580", "map_id": "none", "name": "ALDH1L1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10485817", "map_id": "none", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5693984", "map_id": "CHEBI:12071", "name": "5,10-methylene-THF", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6801458", "map_id": "CHEBI:15638", "name": "5,10-methenyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10485812", "map_id": "Q04448", "name": "Nmdmc", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0010222", "map_id": "FBgn0010222", "name": "Nmdmc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441409", "map_id": "none", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428758", "map_id": "none", "name": "SHMT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W457", "map_id": "Q9W457", "name": "Shmt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029823", "map_id": "FBgn0029823", "name": "Shmt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441407", "map_id": "none", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_197965", "map_id": "CHEBI:27470", "name": "FOLA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_200716", "map_id": "CHEBI:27470", "name": "FOLA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10441404", "map_id": "none", "name": "Homologues of SLC46A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B7YZU3", "map_id": "B7YZU3", "name": "Dmel\\CG8008", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033387", "map_id": "FBgn0033387", "name": "Dmel\\CG8008", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8INF8", "map_id": "Q8INF8", "name": "BcDNA:RH31685", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051321", "map_id": "FBgn0051321", "name": "BcDNA:RH31685", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VY22", "map_id": "Q9VY22", "name": "Dmel\\CG15890", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030576", "map_id": "FBgn0030576", "name": "Dmel\\CG15890", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7R6", "map_id": "A1Z7R6", "name": "SLC46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033388", "map_id": "FBgn0033388", "name": "SLC46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q1EC10", "map_id": "Q1EC10", "name": "Dmel\\CG30345", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050345", "map_id": "FBgn0050345", "name": "Dmel\\CG30345", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA14", "map_id": "Q9VA14", "name": "Dmel\\CG15553", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039817", "map_id": "FBgn0039817", "name": "Dmel\\CG15553", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E8E1", "map_id": "Q0E8E1", "name": "AC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260388", "map_id": "FBgn0260388", "name": "AC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q961H2", "map_id": "Q961H2", "name": "CG8054", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050344", "map_id": "FBgn0050344", "name": "CG8054", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10485825", "map_id": "none", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6803257", "map_id": "CHEBI:63907", "name": "5-formyl-THFPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10485822", "map_id": "Q8MLS1", "name": "Mthfs", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0085453", "map_id": "FBgn0085453", "name": "Mthfs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10485827", "map_id": "none", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10485830", "map_id": "none", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10441461", "map_id": "none", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10441459", "map_id": "none", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10441457", "map_id": "none", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10440753", "map_id": "none", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440748", "map_id": "P17719", "name": "Dhfr", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0004087", "map_id": "FBgn0004087", "name": "Dhfr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440751", "map_id": "none", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10441455", "map_id": "none", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10441438", "map_id": "A1Z7S4", "name": "anon-WO0242455.53", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0033391", "map_id": "FBgn0033391", "name": "anon-WO0242455.53", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441453", "map_id": "none", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10441451", "map_id": "none", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10441448", "map_id": "none", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10441445", "map_id": "Q9VYL1", "name": "Fpgs", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0030407", "map_id": "FBgn0030407", "name": "Fpgs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440743", "map_id": "none", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440740", "map_id": "Q9VYL1", "name": "Fpgs", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441443", "map_id": "none", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10498781", "map_id": "none", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498778", "map_id": "none", "name": "DHFR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P17719", "map_id": "P17719", "name": "Dhfr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469673", "map_id": "none", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_3065953", "map_id": "CHEBI:27870", "name": "BCTN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_29582", "map_id": "CHEBI:15956", "name": "Btn", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10469670", "map_id": "Q9NFP1", "name": "vanin-like", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0040069", "map_id": "FBgn0040069", "name": "vanin-like", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468376", "map_id": "none", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468374", "map_id": "none", "name": "hCBXs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q0E9E2", "map_id": "Q0E9E2", "name": "PCB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027580", "map_id": "FBgn0027580", "name": "PCB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9T5", "map_id": "Q9V9T5", "name": "Mccc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039877", "map_id": "FBgn0039877", "name": "Mccc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9A7", "map_id": "Q9V9A7", "name": "Mccc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042083", "map_id": "FBgn0042083", "name": "Mccc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467405", "map_id": "none", "name": "hCBXs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10467413", "map_id": "none", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_3076887", "map_id": "CHEBI:27870", "name": "BCTN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_199238", "map_id": "CHEBI:15956", "name": "Btn", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_351991", "map_id": "CHEBI:32551", "name": "L-Lys", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10467410", "map_id": "Q9NFP1", "name": "vanin-like", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10441069", "map_id": "none", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441061", "map_id": "B7Z001", "name": "FASN1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158466", "map_id": "CHEBI:17985", "name": "PAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441066", "map_id": "Q8SXB3", "name": "eap", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0052099", "map_id": "FBgn0052099", "name": "eap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440669", "map_id": "none", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196834", "map_id": "CHEBI:15769", "name": "PPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196767", "map_id": "CHEBI:16858", "name": "PPANT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440666", "map_id": "none", "name": "3xPPCDC:3xFMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8MKK3", "map_id": "Q8MKK3", "name": "Ppcdc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050290", "map_id": "FBgn0050290", "name": "Ppcdc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440646", "map_id": "none", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196778", "map_id": "CHEBI:15468", "name": "DP-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440643", "map_id": "Q9VRP4", "name": "Ppat-Dpck", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "FBgn0035632", "map_id": "FBgn0035632", "name": "Ppat-Dpck", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440677", "map_id": "none", "name": "PANK2 phosphorylates PanK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_196820", "map_id": "CHEBI:7916", "name": "PanK", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196786", "map_id": "CHEBI:15905", "name": "PPanK", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440674", "map_id": "Q9NHN2", "name": "fbl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "FBgn0011205", "map_id": "FBgn0011205", "name": "fbl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441076", "map_id": "none", "name": "PANK1/3/4 phosphorylate PanK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441071", "map_id": "Q9NHN2", "name": "fbl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440659", "map_id": "none", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10455438", "map_id": "none", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947561", "map_id": "CHEBI:36264", "name": "MoO4(2-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947496", "map_id": "CHEBI:58698", "name": "MPT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947539", "map_id": "CHEBI:25372", "name": "MoCo", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10455435", "map_id": "none", "name": "3xGPHN:3xMg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P39205", "map_id": "P39205", "name": "cin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000316", "map_id": "FBgn0000316", "name": "cin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455403", "map_id": "none", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947575", "map_id": "CHEBI:60102", "name": "sulfurated MoCo", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10455400", "map_id": "Q9VRA2", "name": "mal", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0002641", "map_id": "FBgn0002641", "name": "mal", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455450", "map_id": "none", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_947537", "map_id": "CHEBI:59648", "name": "Precursor Z", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_947703", "map_id": "CHEBI:17319", "name": "dADE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_174390", "map_id": "CHEBI:57844", "name": "L-Met", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10455447", "map_id": "none", "name": "holo-MOCS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IQF1", "map_id": "Q8IQF1", "name": "Mocs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263241", "map_id": "FBgn0263241", "name": "Mocs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455426", "map_id": "none", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455410", "map_id": "none", "name": "MOCS3:Zn2+ (red.)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VLJ8", "map_id": "Q9VLJ8", "name": "Uba4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032054", "map_id": "FBgn0032054", "name": "Uba4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10455415", "map_id": "none", "name": "MOCS3-S-S(1-):Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10455423", "map_id": "none", "name": "PXLP-K258-NFS1-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VKD3", "map_id": "Q9VKD3", "name": "Nfs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032393", "map_id": "FBgn0032393", "name": "Nfs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497008", "map_id": "none", "name": "VKORC1 inhibitors binds VKORC1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10435910", "map_id": "none", "name": "VKORC1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A1ZAJ5", "map_id": "A1ZAJ5", "name": "Vkor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053544", "map_id": "FBgn0053544", "name": "Vkor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9035082", "map_id": "none", "name": "VKORC1 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10435913", "map_id": "none", "name": "VKORC1 inhibitors:VKORC1 dimer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10486243", "map_id": "none", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_6806891", "map_id": "CHEBI:28869", "name": "menadione", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806657", "map_id": "CHEBI:57533", "name": "GGPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806362", "map_id": "CHEBI:78277", "name": "MK4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_6806656", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10486240", "map_id": "Q9V3R8", "name": "heix", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0028375", "map_id": "FBgn0028375", "name": "heix", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10435915", "map_id": "none", "name": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6806366", "map_id": "CHEBI:90152", "name": "MK4 epoxide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10486235", "map_id": "none", "name": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10486232", "map_id": "A1ZAJ5", "name": "Vkor", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10455791", "map_id": "none", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_975643", "map_id": "CHEBI:17579", "name": "betaC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10455788", "map_id": "none", "name": "BCMO1:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VFS2", "map_id": "Q9VFS2", "name": "ninaB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002937", "map_id": "FBgn0002937", "name": "ninaB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465678", "map_id": "none", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431845", "map_id": "Q8INK3", "name": "fabp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2473616", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465676", "map_id": "none", "name": "RBP1:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2473604", "map_id": "CHEBI:17336", "name": "atROL", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10455773", "map_id": "none", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_975591", "map_id": "CHEBI:17616", "name": "RPALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_975590", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_426576", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10455770", "map_id": "Q9VW80", "name": "Dmel\\CG7365", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0036939", "map_id": "FBgn0036939", "name": "Dmel\\CG7365", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465674", "map_id": "none", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455775", "map_id": "Q8INK3", "name": "fabp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10455779", "map_id": "none", "name": "RBP2:atRAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10467095", "map_id": "none", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473610", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465680", "map_id": "none", "name": "RBP1:atROL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10455781", "map_id": "none", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455777", "map_id": "none", "name": "RBP2:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10467093", "map_id": "none", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467090", "map_id": "none", "name": "AKRs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10470451", "map_id": "none", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5164389", "map_id": "CHEBI:17579", "name": "betaC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5164390", "map_id": "CHEBI:32325", "name": "bION", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5164383", "map_id": "CHEBI:53153", "name": "APO10al", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10470448", "map_id": "none", "name": "BCO2:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10465682", "map_id": "none", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10491072", "map_id": "none", "name": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491068", "map_id": "none", "name": "TTPA:alpha-TOH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_8874708", "map_id": "CHEBI:18145", "name": "alpha-TOH", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "Q8T9G7", "map_id": "Q8T9G7", "name": "Dmel\\CG10026", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032785", "map_id": "FBgn0032785", "name": "Dmel\\CG10026", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2MGL9", "map_id": "Q2MGL9", "name": "Dmel\\CG33965", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053965", "map_id": "FBgn0053965", "name": "Dmel\\CG33965", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJN4", "map_id": "Q9VJN4", "name": "CG13241", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051826", "map_id": "FBgn0051826", "name": "CG13241", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95R34", "map_id": "Q95R34", "name": "BEST:GM01072", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023525", "map_id": "FBgn0023525", "name": "BEST:GM01072", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6NLM7", "map_id": "Q6NLM7", "name": "CG15018", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053514", "map_id": "FBgn0053514", "name": "CG15018", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM11", "map_id": "Q9VM11", "name": "Dmel\\CG5973", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031914", "map_id": "FBgn0031914", "name": "Dmel\\CG5973", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9V4", "map_id": "Q9V9V4", "name": "Dmel\\CG11550", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039864", "map_id": "FBgn0039864", "name": "Dmel\\CG11550", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K1M4", "map_id": "Q7K1M4", "name": "Dmel\\CG1902", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033434", "map_id": "FBgn0033434", "name": "Dmel\\CG1902", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM12", "map_id": "Q9VM12", "name": "Dmel\\CG5958", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031913", "map_id": "FBgn0031913", "name": "Dmel\\CG5958", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCJ2", "map_id": "Q9VCJ2", "name": "Dmel\\CG10300", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039107", "map_id": "FBgn0039107", "name": "Dmel\\CG10300", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I099", "map_id": "Q8I099", "name": "Dmel\\CG2663", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037323", "map_id": "FBgn0037323", "name": "Dmel\\CG2663", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W408", "map_id": "Q9W408", "name": "Dmel\\CG3823", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029863", "map_id": "FBgn0029863", "name": "Dmel\\CG3823", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCJ3", "map_id": "Q9VCJ3", "name": "Dmel\\CG10301", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039106", "map_id": "FBgn0039106", "name": "Dmel\\CG10301", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IPJ5", "map_id": "Q8IPJ5", "name": "CG13770", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051636", "map_id": "FBgn0051636", "name": "CG13770", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W503", "map_id": "Q9W503", "name": "Dmel\\CG3091", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029608", "map_id": "FBgn0029608", "name": "Dmel\\CG3091", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7X8", "map_id": "A1Z7X8", "name": "Dmel\\CG12926", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033437", "map_id": "FBgn0033437", "name": "Dmel\\CG12926", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VD09", "map_id": "Q9VD09", "name": "pinta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038966", "map_id": "FBgn0038966", "name": "pinta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SXR4", "map_id": "Q8SXR4", "name": "Dmel\\CG30339", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050339", "map_id": "FBgn0050339", "name": "Dmel\\CG30339", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q2MGL8", "map_id": "Q2MGL8", "name": "Dmel\\CG33966", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053966", "map_id": "FBgn0053966", "name": "Dmel\\CG33966", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIW5", "map_id": "Q9VIW5", "name": "Dmel\\CG10237", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032783", "map_id": "FBgn0032783", "name": "Dmel\\CG10237", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491070", "map_id": "none", "name": "TTPA:alpha-TOH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10491074", "map_id": "none", "name": "TTPA binds alpha-TOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491066", "map_id": "none", "name": "Homologues of TTPA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10459358", "map_id": "none", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1474124", "map_id": "CHEBI:18372", "name": "DHNTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1475054", "map_id": "CHEBI:15266", "name": "PPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1474179", "map_id": "CHEBI:17804", "name": "PTHP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10459355", "map_id": "none", "name": "p-PTPS hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P48611", "map_id": "P48611", "name": "pr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003141", "map_id": "FBgn0003141", "name": "pr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459534", "map_id": "none", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459531", "map_id": "none", "name": "p-SPR dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O76752", "map_id": "O76752", "name": "Sptr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014032", "map_id": "FBgn0014032", "name": "Sptr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459879", "map_id": "none", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497857", "map_id": "CHEBI:15375", "name": "BH2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10459877", "map_id": "none", "name": "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459347", "map_id": "none", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459344", "map_id": "none", "name": "GCH1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P48596", "map_id": "P48596", "name": "Pu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003162", "map_id": "FBgn0003162", "name": "Pu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459555", "map_id": "none", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459538", "map_id": "none", "name": "PTPS hexamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10459552", "map_id": "none", "name": "Homologues of PRKG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10459890", "map_id": "none", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1497811", "map_id": "CHEBI:16095", "name": "sepiapterin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10459888", "map_id": "none", "name": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459886", "map_id": "none", "name": "SPR dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10446462", "map_id": "none", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389548", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389556", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389536", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389537", "map_id": "CHEBI:16810", "name": "2OG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_113602", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446459", "map_id": "none", "name": "IDH1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "B7Z0E0", "map_id": "B7Z0E0", "name": "Idh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001248", "map_id": "FBgn0001248", "name": "Idh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465151", "map_id": "none", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162209", "map_id": "CHEBI:50775", "name": "DHDB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162215", "map_id": "CHEBI:50776", "name": "MHDB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10465137", "map_id": "Q9VIF3", "name": "Coq3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0032922", "map_id": "FBgn0032922", "name": "Coq3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465148", "map_id": "none", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_2162214", "map_id": "CHEBI:61011", "name": "all-E-10PrP2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162213", "map_id": "CHEBI:30763", "name": "PHB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162207", "map_id": "CHEBI:64136", "name": "DHB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10465145", "map_id": "Q9VHS7", "name": "Coq2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0037574", "map_id": "FBgn0037574", "name": "Coq2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465174", "map_id": "none", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162257", "map_id": "CHEBI:17407", "name": "FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162256", "map_id": "CHEBI:16584", "name": "IPPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10465171", "map_id": "none", "name": "PDSS1/2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9V9Z3", "map_id": "Q9V9Z3", "name": "qless", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051005", "map_id": "FBgn0051005", "name": "qless", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VP87", "map_id": "Q9VP87", "name": "Pdss2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037044", "map_id": "FBgn0037044", "name": "Pdss2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465140", "map_id": "none", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2162212", "map_id": "CHEBI:64182", "name": "DeMQ10H2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2162198", "map_id": "CHEBI:64183", "name": "Q10H2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_216133", "map_id": "none", "name": "Dissociation of CI from COS", "reversible": "false", "notes": "Coastal2 (COS) phosphorylated on Ser572 has reduced affinity for Cubitus Interruptus (CI). This may contribute to partial dissociation of CI from COS complexes.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206734", "map_id": "none", "name": "Phospho (9 sites) Act SMO:Phospho (2 sites) COS:CI:Phospho FU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_206046", "map_id": "P19538", "name": "CI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206634", "map_id": "none", "name": "Phospho (9 sites) Act SMO:Phospho (2 sites) COS:Phospho FU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209220", "map_id": "none", "name": "Liberation of CI from SU(FU) repression", "reversible": "false", "notes": "Cubitus Interruptus (CI) that is spared from proteolysis is liberated from the repressive effects of its direct binding partner, Supressor of Fused (SU(FU)), by Fused (FU) Ser/Thr kinase activity. FU is believed to phosphorylate SU(FU) but it is not known if this relieves repression.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206802", "map_id": "none", "name": "CI:SU(FU)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27279", "map_id": "Q27279", "name": "Phospho SU(FU)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho SU(FU)", "map_id": "Phospho SU(FU)", "name": "Phospho SU(FU)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_205950", "map_id": "Q27279", "name": "Phospho SU(FU)", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_205872", "map_id": "P23647", "name": "FU", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209163", "map_id": "none", "name": "CI transports from the cytosol to the nucleus", "reversible": "false", "notes": "Cubitus Interruptus (CI) access to the nucleus increases in response to Hedgehog signalling, most likely due to reduced cytoplasmic tethering by both Coastal2 (COS) and Suppressor of Fused (SU(FU)) complexes. However, the vast majority of CI is cytoplasmic.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_209215", "map_id": "none", "name": "CI activates transcription", "reversible": "false", "notes": "Cubitus Interruptus (CI) activates transcription of ptc and several tissue-specific target genes that include direct CI binding sites in their regulatory sequences. CREB binding protein, CBP (NEJ) co-activator contributes to transcriptional activation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_209178", "map_id": "none", "name": "N-HH binds to PTC receptor complex", "reversible": "false", "notes": "N-HH bound to Dally-like protein (DLP) is presented to Patched (PTC) receptor and Induced Hedgehog/Brother of Induced Hedgehog (IHOG/BOI) co-receptor to form a ternary complex at the plasma membrane. N-HH binds directly to PTC. Binding is enhanced by the putative co-receptor, IHOG/BOI, which is a type I transmembrane protein that can bind N-HH directly in the presence of Heparin. Signal transduction is also enhanced by DLP, implying that heparan sulphate proteoglycan (HSPG)-associated N-HH may be the most potent form of Hedgehog. Binding of N-HH to PTC leads to PTC internalisation and lysosomal degradation, resulting in a reduction of extracellular N-HH levels and a relief of repression of Smoothened (SMO) by PTC, which depends on the opposing actions of free PTC and N-HH bound PTC.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_216284", "map_id": "none", "name": "N-HH:DLP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9GPL5", "map_id": "Q9GPL5", "name": "DLP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DLP", "map_id": "DLP", "name": "DLP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_206021", "map_id": "P18502", "name": "PTC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_216135", "map_id": "none", "name": "IHOG/BOI dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W4Y6", "map_id": "Q9W4Y6", "name": "BOI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "BOI", "map_id": "BOI", "name": "BOI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_216226", "map_id": "none", "name": "N-HH:DLP:IHOG/BOI dimer:PTC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_216222", "map_id": "none", "name": "COS binds to SMO", "reversible": "false", "notes": "SMO:COS:FU:CI complexes are present prior to Hedgehog signalling owing to direct binding of Smoothened (SMO) to both Coastal2 (COS) and the Ser/Thr kinase Fused (FU).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_216188", "map_id": "none", "name": "COS:CI:FU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206086", "map_id": "P91682", "name": "SMO", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_216146", "map_id": "none", "name": "SMO:COS:CI:FU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209253", "map_id": "none", "name": "Autophosphorylated FU phosphorylates COS", "reversible": "false", "notes": "The Ser/Thr protein kinase, Fused (FU), is capable of autophosphorylation and is proposed to be activated by phosphorylation on at least Thr158 and probably on other residues too. Costal2 (COS), bound to the phosphorylated transmembrane receptor Smoothened (SMO), is itself phosphorylated by FU at Ser572 and Ser931. Both FU and COS promote phosphorylation of SMO and its accumulation at the plasma membrane resulting in a positive feedback loop.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_216158", "map_id": "none", "name": "Phospho (9 sites) Act SMO:COS:CI:FU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_216202", "map_id": "none", "name": "Phosphorylated SMO changes conformation and is activated", "reversible": "false", "notes": "The Smoothened (SMO) large terminal cytoplasmic domain changes conformation in response to phosphorylation and becomes active. The localisation of SMO and its partners shifts from internal vesicles towards the plasma membrane. SMO stability increases results in the SMO:COS:FU:CI complexes at the plasma membrane becoming more abundant.Activation of SMO leads to reduced association of the Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase 1 alpha (CKIalpha), and Casein kinase I epsilon (DCO) with Costal2 (COS). This leads to a reduced phosphorylation of Cubitus Interruptus (CI) and inhibition of CI proteolysis and processing. This increases full-length CI protein levels.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_206727", "map_id": "none", "name": "Phospho (9 sites) SMO:COS:CI:FU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209168", "map_id": "none", "name": "Phosphorylation of SMO by CKIalpha", "reversible": "false", "notes": "Priming phosphorylation of the transmembrane protein Smoothened (SMO) leads to additional phosphorylation by Casein kinase I alpha (CKIalpha) at Ser670, Ser673, Ser690, Ser693, Ser743, and Ser746. Even though SMO has been shown to be explicitly phosphorylated by CKIalpha, phosphorylation of these residues by other CK1 isoforms cannot be ruled out. In addition, other residues are probably phosphorylated by unidentified kinases.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_216105", "map_id": "none", "name": "Phospho (3 sites) SMO:COS:CI:FU", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209341", "map_id": "none", "name": "Phosphorylation of SMO by PKA-C1", "reversible": "false", "notes": "The Ser/Thr kinase, Protein kinase A (PKA-C1) carries out priming phosphorylation of the transmembrane protein Smoothened (SMO) at Ser667, Ser687, and Ser740.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10458816", "map_id": "none", "name": "Activation of voltage gated Potassium channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458813", "map_id": "none", "name": "Octamer of Voltage gated K+ channels", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9PHI0", "map_id": "M9PHI0", "name": "Hk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263220", "map_id": "FBgn0263220", "name": "Hk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17972", "map_id": "P17972", "name": "Shaw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003386", "map_id": "FBgn0003386", "name": "Shaw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYR5", "map_id": "A8DYR5", "name": "Shawl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085395", "map_id": "FBgn0085395", "name": "Shawl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JPB9", "map_id": "Q7JPB9", "name": "sei", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003353", "map_id": "FBgn0003353", "name": "sei", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17970", "map_id": "P17970", "name": "Shab", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262593", "map_id": "FBgn0262593", "name": "Shab", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q02280", "map_id": "Q02280", "name": "eag", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000535", "map_id": "FBgn0000535", "name": "eag", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZB14", "map_id": "A1ZB14", "name": "Elk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011589", "map_id": "FBgn0011589", "name": "Elk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z856", "map_id": "A1Z856", "name": "KCNQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033494", "map_id": "FBgn0033494", "name": "KCNQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P08510", "map_id": "P08510", "name": "Sh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003380", "map_id": "FBgn0003380", "name": "Sh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10451102", "map_id": "none", "name": "PKCalpha phosphorylates HuR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10450960", "map_id": "none", "name": "Homologues of p-S158,S221-ELAVL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10451099", "map_id": "P05130", "name": "Pkc53E", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10451085", "map_id": "none", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_450613", "map_id": "none", "name": "mRNA Transcript Targeted by HuR with Unknown Phosphorylation", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10450946", "map_id": "none", "name": "HuR with Unknown Phosphorylation: mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10451097", "map_id": "none", "name": "PKCdelta phosphorylates HuR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10450973", "map_id": "none", "name": "Homologues of p-S221,S318-ELAVL1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10451094", "map_id": "P83099", "name": "Pkcdelta", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10450981", "map_id": "none", "name": "HuR binds the CRM1 nuclear export machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10450977", "map_id": "none", "name": "HuR:mRNA complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10450932", "map_id": "Q8MUJ1", "name": "phospho-egr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0033483", "map_id": "FBgn0033483", "name": "phospho-egr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450937", "map_id": "Q9V895", "name": "Anp32a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0034282", "map_id": "FBgn0034282", "name": "Anp32a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450939", "map_id": "Q9W1X4", "name": "Nup214", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10450979", "map_id": "none", "name": "HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V895", "map_id": "Q9V895", "name": "Anp32a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MUJ1", "map_id": "Q8MUJ1", "name": "phospho-egr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453156", "map_id": "none", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_517622", "map_id": "none", "name": "mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10450975", "map_id": "none", "name": "HuR with phosphoserine221 and phosphoserine318:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10453154", "map_id": "none", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_450605", "map_id": "none", "name": "mRNA Transcript Targeted by HuR Phosphorylated on Ser158 and Ser318.", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10450962", "map_id": "none", "name": "HuR with phosphoserine221 and phosphoserine158:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10451200", "map_id": "none", "name": "HuR:mRNA complex translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10451164", "map_id": "Q8MUJ1", "name": "phospho-egr", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10451198", "map_id": "none", "name": "HuR:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10451005", "map_id": "none", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451001", "map_id": "P47980", "name": "Tis11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0011837", "map_id": "FBgn0011837", "name": "phospho-Tis11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_450597", "map_id": "none", "name": "mRNA Transcript Targeted by Tristetraproline", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10451003", "map_id": "none", "name": "TTP:mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P47980", "map_id": "P47980", "name": "phospho-Tis11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10451052", "map_id": "none", "name": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450995", "map_id": "none", "name": "Phosphorylated TTP:mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10451031", "map_id": "none", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448993", "map_id": "Q9W1H5", "name": "DCP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0034921", "map_id": "FBgn0034921", "name": "DCP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10451027", "map_id": "E1JJR3", "name": "pcm", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0020261", "map_id": "FBgn0020261", "name": "pcm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449000", "map_id": "Q5U127", "name": "DCP2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036534", "map_id": "FBgn0036534", "name": "DCP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449102", "map_id": "none", "name": "Exosome Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10451029", "map_id": "none", "name": "TTP:mRNA Degradation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q5U127", "map_id": "Q5U127", "name": "DCP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JJR3", "map_id": "E1JJR3", "name": "pcm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1H5", "map_id": "Q9W1H5", "name": "DCP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450999", "map_id": "none", "name": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450997", "map_id": "none", "name": "Phosphorylated TTP:mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10453023", "map_id": "none", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451075", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10453021", "map_id": "none", "name": "Phosphorylated BRF1 (Ser54, Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10451083", "map_id": "none", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451069", "map_id": "none", "name": "BRF1:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10451011", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10451081", "map_id": "none", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451079", "map_id": "none", "name": "BRF1:mRNA Degradation Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10451015", "map_id": "none", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451013", "map_id": "none", "name": "Phosphorylated BRF1 (Ser92, Ser203):mRNA:14-3-3 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10451077", "map_id": "none", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10451092", "map_id": "none", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450523", "map_id": "none", "name": "mRNA Transcript Targeted by BRF1", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10451067", "map_id": "P47980", "name": "Tis11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10451049", "map_id": "none", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451043", "map_id": "none", "name": "AUF1 Dimer (isoform p37 or p40)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_450444", "map_id": "none", "name": "mRNA Transcript Targeted by AUF1(hnRNP D0)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10451047", "map_id": "none", "name": "AUF1 Tetramer: Destabilized mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10451065", "map_id": "none", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451063", "map_id": "none", "name": "Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10451160", "map_id": "none", "name": "AUF1 (hnRNP D0) is ubiquitinylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451156", "map_id": "none", "name": "AUF1 Complexed with Translation and Heat Shock Proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P02825", "map_id": "P02825", "name": "Hsp70Ab", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013276", "map_id": "FBgn0013276", "name": "Hsp70Ab", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8INI8", "map_id": "Q8INI8", "name": "Hsp70Ba", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013277", "map_id": "FBgn0013277", "name": "Hsp70Ba", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG58", "map_id": "Q9VG58", "name": "Hsp70Bbb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051354", "map_id": "FBgn0051354", "name": "Hsp70Bbb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O97125", "map_id": "O97125", "name": "Hsp68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001230", "map_id": "FBgn0001230", "name": "Hsp68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P82910", "map_id": "P82910", "name": "Hsp70Aa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013275", "map_id": "FBgn0013275", "name": "Hsp70Aa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BIS2", "map_id": "Q9BIS2", "name": "Hsp70Bb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013278", "map_id": "FBgn0013278", "name": "Hsp70Bb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P11146", "map_id": "P11146", "name": "Hsc70-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001217", "map_id": "FBgn0001217", "name": "Hsc70-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9BIR7", "map_id": "Q9BIR7", "name": "Hsp70Bc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013279", "map_id": "FBgn0013279", "name": "Hsp70Bc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSI1", "map_id": "Q9VSI1", "name": "Dmel\\CG7182", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035878", "map_id": "FBgn0035878", "name": "Dmel\\CG7182", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10451158", "map_id": "none", "name": "AUF1 binds translation and heat shock proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451154", "map_id": "none", "name": "Homologues of HSPA1A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10451107", "map_id": "Q8IQW5", "name": "HspB8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10447995", "map_id": "P11147", "name": "Hsc70-4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10451162", "map_id": "none", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450386", "map_id": "none", "name": "mRNA Transcript Targeted by KSRP", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10451020", "map_id": "A1ZAK8", "name": "Psi", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0014870", "map_id": "FBgn0014870", "name": "phospho-Psi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10451022", "map_id": "none", "name": "KSRP:mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1ZAK8", "map_id": "A1ZAK8", "name": "phospho-Psi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10451208", "map_id": "none", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451088", "map_id": "A1ZAK8", "name": "phospho-Psi", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10451206", "map_id": "none", "name": "Phosphorylated KSRP (Ser193):14-3-3zeta Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10451090", "map_id": "none", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10492435", "map_id": "none", "name": "CDK6 binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492431", "map_id": "none", "name": "RUNX1,RUNX1:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492429", "map_id": "Q7K306", "name": "Cdk4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10492433", "map_id": "none", "name": "RUNX1,RUNX1:CBFB:CDK6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492437", "map_id": "none", "name": "CCND3,(CCND1,CCND2) binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489792", "map_id": "none", "name": "Homologues of RUNX1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10489796", "map_id": "none", "name": "RUNX1:CCND3,(CCND1,CCND2)", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10489798", "map_id": "none", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489782", "map_id": "Q24040", "name": "Bgb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10466198", "map_id": "none", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10466195", "map_id": "none", "name": "Slo3 Channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q03720", "map_id": "Q03720", "name": "slo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003429", "map_id": "FBgn0003429", "name": "slo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449198", "map_id": "none", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449195", "map_id": "none", "name": "AQP1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9V5Z7", "map_id": "Q9V5Z7", "name": "Drip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015872", "map_id": "FBgn0015872", "name": "Drip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449388", "map_id": "none", "name": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449372", "map_id": "none", "name": "AQP2 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "true" }, { "id": "Q9W1M4", "map_id": "Q9W1M4", "name": "Eglp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034882", "map_id": "FBgn0034882", "name": "Eglp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1M2", "map_id": "Q9W1M2", "name": "Eglp3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034884", "map_id": "FBgn0034884", "name": "Eglp3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P23645", "map_id": "P23645", "name": "bib", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000180", "map_id": "FBgn0000180", "name": "bib", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D3DMU9", "map_id": "D3DMU9", "name": "Prip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033635", "map_id": "FBgn0033635", "name": "Prip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449386", "map_id": "none", "name": "p-S256-AQP2 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "true" }, { "id": "reaction_10449412", "map_id": "none", "name": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449231", "map_id": "none", "name": "p-S256-AQP2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10449409", "map_id": "none", "name": "MYO5B:RABFIP2:RAB11A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "Q9VWS3", "map_id": "Q9VWS3", "name": "Rip11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027335", "map_id": "FBgn0027335", "name": "Rip11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6Z8", "map_id": "A1Z6Z8", "name": "didum", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261397", "map_id": "FBgn0261397", "name": "didum", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449251", "map_id": "none", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10449248", "map_id": "none", "name": "AQP4 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449234", "map_id": "none", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10449200", "map_id": "none", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10432557", "map_id": "none", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76112", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10432552", "map_id": "Q9Y137", "name": "mino", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "FBgn0027579", "map_id": "FBgn0027579", "name": "mino", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432635", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76103", "map_id": "CHEBI:17815", "name": "DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_549167", "map_id": "CHEBI:17855", "name": "TAG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10432632", "map_id": "none", "name": "DGAT1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q960U8", "map_id": "Q960U8", "name": "mdy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004797", "map_id": "FBgn0004797", "name": "mdy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10484777", "map_id": "none", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6800352", "map_id": "CHEBI:17389", "name": "2AG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1500578", "map_id": "CHEBI:17984", "name": "acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10484774", "map_id": "none", "name": "MOGAT1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q7JYK2", "map_id": "Q7JYK2", "name": "Dmel\\CG1941", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033214", "map_id": "FBgn0033214", "name": "Dmel\\CG1941", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K1C2", "map_id": "Q7K1C2", "name": "Dgat2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033215", "map_id": "FBgn0033215", "name": "Dgat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z739", "map_id": "A1Z739", "name": "Dmel\\CG1946", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033216", "map_id": "FBgn0033216", "name": "Dmel\\CG1946", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453385", "map_id": "none", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10453382", "map_id": "none", "name": "Homologues of DGAT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10432581", "map_id": "none", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432578", "map_id": "none", "name": "GK,GK2,GK3P", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7JY99", "map_id": "Q7JY99", "name": "Dmel\\CG8298", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033673", "map_id": "FBgn0033673", "name": "Dmel\\CG8298", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432625", "map_id": "none", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432618", "map_id": "Q8SXP0", "name": "Lpin", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10487894", "map_id": "none", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8876730", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10487891", "map_id": "none", "name": "Homologues of PNPLA5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VXY8", "map_id": "Q9VXY8", "name": "dob", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030607", "map_id": "FBgn0030607", "name": "dob", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JI03", "map_id": "E1JI03", "name": "bmm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036449", "map_id": "FBgn0036449", "name": "bmm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471590", "map_id": "none", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471582", "map_id": "Q8INK3", "name": "fabp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10471588", "map_id": "none", "name": "FABPs:LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8954142", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10439494", "map_id": "none", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_188458", "map_id": "CHEBI:15978", "name": "G3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_188451", "map_id": "CHEBI:57642", "name": "DHAP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10439491", "map_id": "Q7K569", "name": "Gpo1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0022160", "map_id": "FBgn0022160", "name": "Gpo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_209331", "map_id": "none", "name": "Formation of the 'scaffold complex'", "reversible": "false", "notes": "The kinesin-related protein, Costal2 (COS), forms a microtubule-associated 'scaffold complex' with Cubitus Interruptus (CI) and the Ser/Thr protein kinase Fused (FU). CI also associates directly with the Supressor of Fused (SU(FU)) protein in a separate complex. Complexes containing CI, COS, FU and SU(FU) are detectable but rare. The Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase I alpha (CKIalpha), and Casein kinase I epsilon (DCO) all bind to the scaffold protein COS.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_205832", "map_id": "O16844", "name": "COS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_205931", "map_id": "P12370", "name": "PKA-C1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_216136", "map_id": "none", "name": "Formation of the CI:SU(FU) complex", "reversible": "false", "notes": "Cubitus Interruptus (CI) forms a separate complex with the Supressor of Fused (SU(FU)) protein.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206064", "map_id": "Q27279", "name": "SU(FU)", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209252", "map_id": "none", "name": "CI75 inhibits transcription", "reversible": "false", "notes": "Upon arrival in the nucleus, truncated Cubitus Interruptus (CI75) represses transcription. Sensitive target genes include hh and dpp, but not ptc and repression depends on direct DNA-binding sites for CI75.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_205741", "map_id": "P19538", "name": "CI75", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_209370", "map_id": "none", "name": "CI75 transports from the cytosol to the nucleus", "reversible": "false", "notes": "Truncated Cubitus Interruptus (CI75) translocates from the cytosol to the nucleus.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_209313", "map_id": "none", "name": "Autocleavage of HH", "reversible": "false", "notes": "The autoprocessing event results in cleavage of Hedgehog (HH) between Gly207 and Cys208, coupled to the covalent addition of cholesterol to Gly207 via an ester linkage to form N-HH.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_205973", "map_id": "Q02936", "name": "HH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206216", "map_id": "Q02936", "name": "C-HH", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206215", "map_id": "Q02936", "name": "N-HH", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209271", "map_id": "none", "name": "N-HH moves from the cytosol to the extracellular region", "reversible": "false", "notes": "With the help of the transmembrane protein Dispatched (DISP), N-HH is secreted from the cytosol to the extracellular region.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_206055", "map_id": "Q9VNJ5", "name": "DISP", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_205888", "map_id": "Q02936", "name": "N-HH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_209272", "map_id": "none", "name": "N-HH binds to the transmembrane HSPG proteins", "reversible": "false", "notes": "N-HH movement between cells is facilitated by the glypicans aka heparan sulphate proteoglycan proteins (HSPGs), Dally (DALLY) and Dally-like protein (DLP) which require heparan sulphate modification by the Exostosin (EXT) family proteins tout-velu (TTV), brother of tout-velu (BOTV) and sister of tout-velu (EXT2) for this purpose. N-HH can form multimers, associated with enhanced movement of vertebrate Sonic Hedgehog, and can associate with lipophorin-containing lipophorin particles which appear to enhance N-HH movement. The protein Shifted (SHF) also facilitates HH movement.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_206547", "map_id": "none", "name": "HSPG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_207018", "map_id": "none", "name": "N-HH:HSPG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209357", "map_id": "none", "name": "N-HH is palmitoylated by RASP", "reversible": "false", "notes": "After removal of an N-terminal signal sequence, RASP, a protein-cysteine N-palmitoyltransferase, palmitoylates the new N-terminus (CGPGR..) via a thiol intermediate that resolves into a stable amide linkage. Palmitoylation efficiency is increased by prior addition of cholesterol at the C-terminus.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76168", "map_id": "CHEBI:15756", "name": "PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17941", "compartment_display": "early endosome", "complex": "false" }, { "id": "species_205927", "map_id": "Q9VZU2", "name": "RASP", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209185", "map_id": "none", "name": "Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for monomeric peptidoglycans (PGN). However, when monomeric PGN binds to PGRP-LCx receptor primarily through its elongated stem peptide, the unique disaccharide GlcNAc-MurNAc(anhydro) residues of the ligand are then presented by PGRP-LCx receptor in such a way as to make favourable interactions with the PGRP-LCa receptor ectodomain. The receptors are now in close proximity and can heterodimerise.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_205720", "map_id": "Q9GNK5-1", "name": "PGRP-LCa", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_206681", "map_id": "none", "name": "Mono PGN:PGRP-LCx", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_206990", "map_id": "none", "name": "Mono PGN:PGRP-LCx:PGRP-LCa", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209158", "map_id": "none", "name": "Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane", "reversible": "false", "notes": "The binding of polymeric peptidoglycan (PGN) to PGRP-LCx receptor results in adjacent PGRP-LCx receptors additionally binding to PGN. This brings the receptors into close enough proximity for them to multimerise.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_207039", "map_id": "none", "name": "Poly PGN:PGRP-LCx", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_205794", "map_id": "Q9GNK5-2", "name": "PGRP-LCx", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_354316", "map_id": "none", "name": "Poly PGN:PGRP-LCx oligomer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_214395", "map_id": "none", "name": "Monomeric PGN bound PGRP-LE oligomerises in the cytosol", "reversible": "false", "notes": "The binding of monomeric peptidoglycans (PGN) to PGRP-LE receptor results in adjacent PGRP-LE receptors binding to the complex and forming a PGRP-LE oligomer.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_214396", "map_id": "none", "name": "Mono PGN:PGRP-LE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_354246", "map_id": "none", "name": "Mono PGN:PGRP-LE oligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10430841", "map_id": "none", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430368", "map_id": "none", "name": "40S ribosomal complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10430435", "map_id": "none", "name": "eIF3 subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10430837", "map_id": "none", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430818", "map_id": "none", "name": "80S ribosome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V597", "map_id": "Q9V597", "name": "RpL31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0285949", "map_id": "FBgn0285949", "name": "RpL31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P04359", "map_id": "P04359", "name": "RpL32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002626", "map_id": "FBgn0002626", "name": "RpL32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W499", "map_id": "Q9W499", "name": "RpL35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029785", "map_id": "FBgn0029785", "name": "RpL35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P19889", "map_id": "P19889", "name": "RpLP0", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000100", "map_id": "FBgn0000100", "name": "RpLP0", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNB9", "map_id": "Q9VNB9", "name": "RpL35A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037328", "map_id": "FBgn0037328", "name": "RpL35A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P08570", "map_id": "P08570", "name": "RpLP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002593", "map_id": "FBgn0002593", "name": "RpLP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49630", "map_id": "P49630", "name": "RpL36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002579", "map_id": "FBgn0002579", "name": "RpL36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P05389", "map_id": "P05389", "name": "RpLP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003274", "map_id": "FBgn0003274", "name": "RpLP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXX8", "map_id": "Q9VXX8", "name": "RpL37a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030616", "map_id": "FBgn0030616", "name": "RpL37a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTP4", "map_id": "Q9VTP4", "name": "RpL10Ab", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036213", "map_id": "FBgn0036213", "name": "RpL10Ab", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJY6", "map_id": "Q9VJY6", "name": "RpL24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032518", "map_id": "FBgn0032518", "name": "RpL24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P50887", "map_id": "P50887", "name": "RpL22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015288", "map_id": "FBgn0015288", "name": "RpL22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBN5", "map_id": "Q9VBN5", "name": "RpL27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039359", "map_id": "FBgn0039359", "name": "RpL27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVU2", "map_id": "Q9VVU2", "name": "RpL26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036825", "map_id": "FBgn0036825", "name": "RpL26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P41092", "map_id": "P41092", "name": "RpL27A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0285948", "map_id": "FBgn0285948", "name": "RpL27A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16797", "map_id": "O16797", "name": "RpL3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020910", "map_id": "FBgn0020910", "name": "RpL3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZS5", "map_id": "Q9VZS5", "name": "RpL28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035422", "map_id": "FBgn0035422", "name": "RpL28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLT7", "map_id": "Q9VLT7", "name": "RpL36A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031980", "map_id": "FBgn0031980", "name": "RpL36A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24154", "map_id": "Q24154", "name": "RpL29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016726", "map_id": "FBgn0016726", "name": "RpL29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ19", "map_id": "Q9VJ19", "name": "RpL30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086710", "map_id": "FBgn0086710", "name": "RpL30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O16130", "map_id": "O16130", "name": "RpL39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023170", "map_id": "FBgn0023170", "name": "RpL39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3G1", "map_id": "Q9V3G1", "name": "RpL8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261602", "map_id": "FBgn0261602", "name": "RpL8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS34", "map_id": "Q9VS34", "name": "RpL18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", 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"P55841", "map_id": "P55841", "name": "RpL14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017579", "map_id": "FBgn0017579", "name": "RpL14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P32100", "map_id": "P32100", "name": "RpL7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005593", "map_id": "FBgn0005593", "name": "RpL7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17445", "map_id": "O17445", "name": "RpL15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028697", "map_id": "FBgn0028697", "name": "RpL15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P46223", "map_id": "P46223", "name": "RpL7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014026", "map_id": "FBgn0014026", "name": "RpL7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3W8", "map_id": "Q9W3W8", "name": "RpL17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029897", "map_id": "FBgn0029897", "name": "RpL17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10430816", "map_id": "none", "name": "60S ribosomal complex", "type": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430523", "map_id": "Q9XZ56", "name": "Thor", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10430529", "map_id": "none", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430474", "map_id": "none", "name": "eIF4A subunits complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10430499", "map_id": "none", "name": "eIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10430568", "map_id": "none", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430564", "map_id": "none", "name": "eIF2B subunits complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VAD4", "map_id": "Q9VAD4", "name": "eIF2Balpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039726", "map_id": "FBgn0039726", "name": "eIF2Balpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W541", "map_id": "Q9W541", "name": "eIF2Bepsilon", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023512", "map_id": "FBgn0023512", "name": "eIF2Bepsilon", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1Q8", "map_id": "Q9W1Q8", "name": "eIF2Bdelta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034858", "map_id": "FBgn0034858", "name": "eIF2Bdelta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76863", "map_id": "O76863", "name": "eIF2Bbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024996", "map_id": "FBgn0024996", "name": "eIF2Bbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZA22", "map_id": "A1ZA22", "name": "eIF2Bgamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034029", "map_id": "FBgn0034029", "name": "eIF2Bgamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10430517", "map_id": "none", "name": "eIF2:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10430566", "map_id": "none", "name": "eIF2:GDP: eIF2B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10430848", "map_id": "none", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435558", "map_id": "Q9VNE9", "name": "phospho-RpL13A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10435560", "map_id": "none", "name": "phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10447275", "map_id": "none", "name": "PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_422139", "map_id": "none", "name": "Peroxisome Proliferator Receptor Element (PPRE)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10445291", "map_id": "P13055", "name": "Eip75B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10447235", "map_id": "none", "name": "PPARA:RXRA heterodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10447273", "map_id": "none", "name": "PPARA:RXRA heterodimer recruits corepressors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10447233", "map_id": "Q95RJ9", "name": "ebi", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10447226", "map_id": "Q7KTS4", "name": "HDAC3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10447231", "map_id": "Q95RJ9", "name": "ebi", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10447237", "map_id": "none", "name": "PPARA:RXRA Corepressor complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10447271", "map_id": "none", "name": "Fatty acid ligands activate PPARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10447259", "map_id": "none", "name": "Coactivators of PPARalpha", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VEA4", "map_id": "Q9VEA4", "name": "Tgs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266195", "map_id": "FBgn0266195", "name": "Tgs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYG2", "map_id": "Q9VYG2", "name": "Bap60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025463", "map_id": "FBgn0025463", "name": "Bap60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9661418", "map_id": "CHEBI:16990", "name": "BIL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10447263", "map_id": "none", "name": "FABP1:ligands of PPARA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "CHEBI:17351", "map_id": "CHEBI:17351", "name": "CHEBI:17351", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10447269", "map_id": "none", "name": "PPARA:RXRA Coactivator complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10447261", "map_id": "Q8INK3", "name": "fabp", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10443214", "map_id": "none", "name": "CYP4F12 18-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_113534", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_140356", "map_id": "CHEBI:15843", "name": "ARA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113601", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113564", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_352318", "map_id": "CHEBI:63590", "name": "18OH-ARA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10443211", "map_id": "none", "name": "Cytochrome P450 (CYP4F12 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10443224", "map_id": "none", "name": "CYP4B1 12-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215075", "map_id": "CHEBI:19138", "name": "12-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10443221", "map_id": "none", "name": "Cytochrome P450 (CYP4B1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10443253", "map_id": "none", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215062", "map_id": "none", "name": "cis-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:34130", "map_id": "CHEBI:34130", "name": "CHEBI:34130", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34157", "map_id": "CHEBI:34157", "name": "CHEBI:34157", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2142739", "map_id": "CHEBI:34450", "name": "5,6-EET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "CHEBI:34490", "map_id": "CHEBI:34490", "name": "CHEBI:34490", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10443250", "map_id": "none", "name": "Cytochrome P450 (CYP2J2 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10433058", "map_id": "none", "name": "CYP4A11 12-hydroxylates DDCX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_42373", "map_id": "CHEBI:39567", "name": "12OH-DDCX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10433055", "map_id": "none", "name": "Cytochrome P450 (CYP4A11 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10465651", "map_id": "none", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10465647", "map_id": "none", "name": "FDXR:FAD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9V3T9", "map_id": "Q9V3T9", "name": "dare", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015582", "map_id": "FBgn0015582", "name": "dare", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465645", "map_id": "none", "name": "FDXR:FADH2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10465649", "map_id": "none", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10459056", "map_id": "none", "name": "FDX1,FDX2 (oxidized)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33737", "map_id": "CHEBI:33737", "name": "CHEBI:33737", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P37193", "map_id": "P37193", "name": "Fdx1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011769", "map_id": "FBgn0011769", "name": "Fdx1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SZA8", "map_id": "Q8SZA8", "name": "Fdx2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035529", "map_id": "FBgn0035529", "name": "Fdx2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10459048", "map_id": "none", "name": "FDX1,FDX2 (reduced)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:33738", "map_id": "CHEBI:33738", "name": "CHEBI:33738", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459064", "map_id": "none", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113531", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10459062", "map_id": "none", "name": "FXN:ISD11:NFS1:ISCU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O46098", "map_id": "O46098", "name": "bcn92", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013432", "map_id": "FBgn0013432", "name": "bcn92", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHK6", "map_id": "Q9VHK6", "name": "IscU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037637", "map_id": "FBgn0037637", "name": "IscU", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W385", "map_id": "Q9W385", "name": "fh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030092", "map_id": "FBgn0030092", "name": "fh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10459032", "map_id": "none", "name": "2 Iron:FXN:NFS1:ISD11:ISCU", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10491819", "map_id": "none", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10491798", "map_id": "none", "name": "GLRX5:2Fe-2S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q8SXQ5", "map_id": "Q8SXQ5", "name": "Dmel\\CG14407", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030584", "map_id": "FBgn0030584", "name": "Dmel\\CG14407", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:33739", "map_id": "CHEBI:33739", "name": "CHEBI:33739", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491810", "map_id": "none", "name": "ISCA1:ISCA2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VC65", "map_id": "Q9VC65", "name": "Dmel\\CG13623", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039205", "map_id": "FBgn0039205", "name": "Dmel\\CG13623", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T3X9", "map_id": "Q8T3X9", "name": "MagR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026666", "map_id": "FBgn0026666", "name": "MagR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491796", "map_id": "Q8SXQ5", "name": "Dmel\\CG14407", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10491812", "map_id": "none", "name": "ISCA1:ISCA2:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:49883", "map_id": "CHEBI:49883", "name": "CHEBI:49883", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491817", "map_id": "A8JNT7", "name": "Hsc20", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0263606", "map_id": "FBgn0263606", "name": "Hsc20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459059", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_379721", "map_id": "CHEBI:35235", "name": "L-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10459050", "map_id": "none", "name": "FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_379697", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10443243", "map_id": "none", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_211993", "map_id": "CHEBI:34665", "name": "DSQ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211952", "map_id": "CHEBI:63800", "name": "HDBQ", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10432787", "map_id": "none", "name": "Cytochrome P450 (CYP2D6 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10432790", "map_id": "none", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_39703", "map_id": "none", "name": "DEXM", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_143501", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_76455", "map_id": "none", "name": "DEXT", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10465550", "map_id": "none", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442018", "map_id": "none", "name": "Homologues of FN1(32-2386)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10442026", "map_id": "none", "name": "Integrin alpha5beta1:FN1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10465548", "map_id": "none", "name": "Integrin alpha5beta1:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10442028", "map_id": "none", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442020", "map_id": "none", "name": "FN1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10442024", "map_id": "none", "name": "Integrin alpha5beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466200", "map_id": "none", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10498752", "map_id": "none", "name": "XPO1 (CRM1) binds to BACH1:Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10498740", "map_id": "none", "name": "BACH1:Hemes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VYJ8", "map_id": "Q9VYJ8", "name": "Dmel\\CG15725", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030417", "map_id": "FBgn0030417", "name": "Dmel\\CG15725", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498742", "map_id": "none", "name": "XPO1:BACH1:Hemes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10455099", "map_id": "none", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9707310", "map_id": "none", "name": "Hemes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_9707308", "map_id": "none", "name": "Hemes", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498750", "map_id": "none", "name": "XPO1:BACH1:Hemes are transported out of the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498748", "map_id": "none", "name": "XPO1:BACH1:Hemes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10458287", "map_id": "none", "name": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458178", "map_id": "none", "name": "SLC4A1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VT48", "map_id": "Q9VT48", "name": "Ae2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458285", "map_id": "none", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1237009", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10458236", "map_id": "none", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10458231", "map_id": "none", "name": "CA4:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VH26", "map_id": "Q9VH26", "name": "CAH7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037788", "map_id": "FBgn0037788", "name": "CAH7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458283", "map_id": "none", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10459562", "map_id": "none", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459557", "map_id": "none", "name": "CA1:Zn2+,CA2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W3C8", "map_id": "Q9W3C8", "name": "CAH3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030056", "map_id": "FBgn0030056", "name": "CAH3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V396", "map_id": "Q9V396", "name": "CAH1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027844", "map_id": "FBgn0027844", "name": "CAH1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458234", "map_id": "none", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10459560", "map_id": "none", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10457039", "map_id": "none", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10456947", "map_id": "none", "name": "E3:Ub:substrate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W3V3", "map_id": "Q9W3V3", "name": "Dmel\\CG14435", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029911", "map_id": "FBgn0029911", "name": "Dmel\\CG14435", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VN58", "map_id": "Q9VN58", "name": "ctrip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260794", "map_id": "FBgn0260794", "name": "ctrip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VY46", "map_id": "Q9VY46", "name": "Fbxl4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030555", "map_id": "FBgn0030555", "name": "Fbxl4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6E0", "map_id": "A1Z6E0", "name": "gus", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026238", "map_id": "FBgn0026238", "name": "gus", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZ21", "map_id": "Q9XZ21", "name": "snama", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086129", "map_id": "FBgn0086129", "name": "snama", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9MRI4", "map_id": "M9MRI4", "name": "Trim9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051721", "map_id": "FBgn0051721", "name": "Trim9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSB2", "map_id": "Q9VSB2", "name": "CG7388", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052369", "map_id": "FBgn0052369", "name": "CG7388", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2JF73", "map_id": "X2JF73", "name": "HUWE1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030674", "map_id": "FBgn0030674", "name": "HUWE1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ14", "map_id": "Q9VJ14", "name": "mib2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086442", "map_id": "FBgn0086442", "name": "mib2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIK3", "map_id": "Q9VIK3", "name": "Dmel\\CG9316", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032878", "map_id": "FBgn0032878", "name": "Dmel\\CG9316", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPY2", "map_id": "Q9VPY2", "name": "Plap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024314", "map_id": "FBgn0024314", "name": "Plap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMY0", "map_id": "Q9VMY0", "name": "jet", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031652", "map_id": "FBgn0031652", "name": "jet", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYA6", "map_id": "A8DYA6", "name": "Dmel\\CG9003", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033639", "map_id": "FBgn0033639", "name": "Dmel\\CG9003", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMI1", "map_id": "Q9VMI1", "name": "Fbw5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031773", "map_id": "FBgn0031773", "name": "Fbw5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SX44", "map_id": "Q8SX44", "name": "CG32429", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053969", "map_id": "FBgn0053969", "name": "CG32429", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYW5", "map_id": "Q9VYW5", "name": "Dmel\\CG2247", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030320", "map_id": "FBgn0030320", "name": "Dmel\\CG2247", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTM4", "map_id": "Q9VTM4", "name": "Dmel\\CG11658", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036196", "map_id": "FBgn0036196", "name": "Dmel\\CG11658", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH60", "map_id": "Q9VH60", "name": "FBXO11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037760", "map_id": "FBgn0037760", "name": "FBXO11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTL8", "map_id": "Q9VTL8", "name": "Dmel\\CG32085", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052085", "map_id": "FBgn0052085", "name": "Dmel\\CG32085", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VU65", "map_id": "Q9VU65", "name": "Poc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036354", "map_id": "FBgn0036354", "name": "Poc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG61", "map_id": "Q9VG61", "name": "Dmel\\CG5961", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038056", "map_id": "FBgn0038056", "name": "Dmel\\CG5961", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX91", "map_id": "Q9VX91", "name": "Ubr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030809", "map_id": "FBgn0030809", "name": "Ubr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86B79", "map_id": "Q86B79", "name": "unk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004395", "map_id": "FBgn0004395", "name": "unk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JR34", "map_id": "Q7JR34", "name": "CG12339", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053144", "map_id": "FBgn0053144", "name": "CG12339", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E8NHA2", "map_id": "E8NHA2", "name": "Herc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035207", "map_id": "FBgn0035207", "name": "Herc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHI7", "map_id": "Q9VHI7", "name": "Iru", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037653", "map_id": "FBgn0037653", "name": "Iru", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10456941", "map_id": "none", "name": "Ubiquitin:E2 conjugating enzymes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10456939", "map_id": "none", "name": "E2 Ubiquitin-conjugating enzyme", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10457005", "map_id": "none", "name": "E3:K48-polyubiquitinated substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457007", "map_id": "none", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983123", "map_id": "none", "name": "K48polyUb-antigenic substrate", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10456828", "map_id": "none", "name": "E3 ligases in proteasomal degradation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457036", "map_id": "none", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457028", "map_id": "none", "name": "Ubiquitin activating E1 enzymes", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10457030", "map_id": "none", "name": "E1 bound ubiquitin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457033", "map_id": "none", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10456950", "map_id": "none", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10456943", "map_id": "none", "name": "Ag-substrate:E3:E2:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457186", "map_id": "none", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983036", "map_id": "CHEBI:25676", "name": "precursor peptide fragment (>16 aa)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_983032", "map_id": "CHEBI:25676", "name": "oligopeptide fragment (8-16aa)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8942986", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10457183", "map_id": "none", "name": "IFN gamma stimulated aminopeptidases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V6K1", "map_id": "Q9V6K1", "name": "TppII", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020370", "map_id": "FBgn0020370", "name": "TppII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2JEJ0", "map_id": "X2JEJ0", "name": "Dmel\\CG1440", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030038", "map_id": "FBgn0030038", "name": "Dmel\\CG1440", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRH1", "map_id": "Q8IRH1", "name": "Psa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261243", "map_id": "FBgn0261243", "name": "Psa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0KI25", "map_id": "Q0KI25", "name": "Dmel\\CG4467", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039064", "map_id": "FBgn0039064", "name": "Dmel\\CG4467", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0KI00", "map_id": "Q0KI00", "name": "SP1029", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263236", "map_id": "FBgn0263236", "name": "SP1029", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2S8", "map_id": "Q9W2S8", "name": "Dmel\\CG9806", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030222", "map_id": "FBgn0030222", "name": "Dmel\\CG9806", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2S7", "map_id": "Q9W2S7", "name": "pepCG2111", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030223", "map_id": "FBgn0030223", "name": "pepCG2111", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1S1", "map_id": "Q9W1S1", "name": "BEST:LD34564", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0046253", "map_id": "FBgn0046253", "name": "BEST:LD34564", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTL4", "map_id": "Q9VTL4", "name": "Dmel\\CG6071", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036186", "map_id": "FBgn0036186", "name": "Dmel\\CG6071", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJN2", "map_id": "Q9VJN2", "name": "BG:DS00365.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028935", "map_id": "FBgn0028935", "name": "BG:DS00365.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VD87", "map_id": "Q9VD87", "name": "Dmel\\CG5849", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038897", "map_id": "FBgn0038897", "name": "Dmel\\CG5849", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAM2", "map_id": "Q9VAM2", "name": "Dmel\\CG11951", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039656", "map_id": "FBgn0039656", "name": "Dmel\\CG11951", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95SR0", "map_id": "Q95SR0", "name": "CG11955", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051445", "map_id": "FBgn0051445", "name": "CG11955", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SWX4", "map_id": "Q8SWX4", "name": "CG5839", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051343", "map_id": "FBgn0051343", "name": "CG5839", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MRN5", "map_id": "Q8MRN5", "name": "CG5839", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457041", "map_id": "none", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_983035", "map_id": "none", "name": "antigenic substrate", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10457009", "map_id": "none", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_209377", "map_id": "none", "name": "Polymeric PGN binds to PGRP-LCx at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCx, receptor exhibits strong affinity for both polymeric and monomeric peptidoglycans.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_206912", "map_id": "none", "name": "Poly PGN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_209355", "map_id": "none", "name": "Monomeric PGN binds to PGRP-LCx at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for peptidoglycans (PGN). However, PGRP-LCx receptor exhibits strong affinity for them.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_205686", "map_id": "CHEBI:46763", "name": "Mono PGN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_214410", "map_id": "none", "name": "Monomeric PGN binds to PGRP-LE in the cytosol", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LE receptor contains no predicted transmembrane domain or signal sequence and so is predicted to be an intracellular receptor. The recognition of the monomeric diaminopimelic acid (DAP)-type peptidoglycan (PGN) tracheal cytotoxin, TCT by PGRP-LE occurs intracellularly. However, it is postulated that the PGRP domain of a truncated PGRP-LE can also function outside the cell in a CD14-like manner by presenting DAP-type PGNs to cell surface PGRP-LC receptors.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_214412", "map_id": "Q9VXN9", "name": "PGRP-LE", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_214418", "map_id": "none", "name": "REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The NF-kappaB orthologue, Relish, binds to the caspase-8 orthologue, DREDD.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206135", "map_id": "Q94527", "name": "REL", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_214406", "map_id": "none", "name": "Mono PGN:PGRP-LE oligomer:IMD:BG4:DREDD:REL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209244", "map_id": "none", "name": "REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The NF-kappaB orthologue, Relish, binds to the caspase-8 orthologue, DREDD.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_354323", "map_id": "none", "name": "PGN:PGRP-LC oligomer:IMD:BG4:DREDD:REL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209221", "map_id": "none", "name": "Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Upon ligand binding and receptor multimerisation at the plasma membrane, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the cytoplasmic part of the receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_354313", "map_id": "none", "name": "PGN:PGRP-LC oligomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_205887", "map_id": "Q9V3B4", "name": "BG4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206183", "map_id": "Q7K4Z4", "name": "IMD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_214405", "map_id": "none", "name": "Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Upon monomeric peptidoglycan (PGN) binding and receptor multimerisation in the cytosol, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the PGRP-LE receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10433119", "map_id": "none", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433113", "map_id": "none", "name": "CE:Pol II CTD:Spt5 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VY44", "map_id": "Q9VY44", "name": "mRNA-cap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030556", "map_id": "FBgn0030556", "name": "mRNA-cap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJQ4", "map_id": "Q9VJQ4", "name": "Rnmt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286027", "map_id": "FBgn0286027", "name": "Rnmt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_72084", "map_id": "none", "name": "nascent pre-mRNA transcript", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433117", "map_id": "none", "name": "Capping complex (initial)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433149", "map_id": "none", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10429248", "map_id": "none", "name": "RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10429169", "map_id": "none", "name": "Cap Binding Complex (CBC)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433131", "map_id": "none", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433121", "map_id": "none", "name": "Capping complex (hydrolyzed)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_113571", "map_id": "CHEBI:15996", "name": "GTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433128", "map_id": "none", "name": "Capping complex (intermediate)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_111349", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433147", "map_id": "none", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10433115", "map_id": "none", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433105", "map_id": "Q9VJQ4", "name": "Rnmt", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10433089", "map_id": "none", "name": "RNA Pol II with phosphorylated CTD: CE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433111", "map_id": "Q9V460", "name": "phospho-Spt5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433145", "map_id": "none", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433138", "map_id": "none", "name": "Capping complex (with freed 5'- GMP)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433142", "map_id": "none", "name": "mRNA capping factors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433095", "map_id": "none", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433093", "map_id": "none", "name": "Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433087", "map_id": "Q9VY44", "name": "mRNA-cap", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10433124", "map_id": "none", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10433140", "map_id": "none", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433133", "map_id": "none", "name": "Capping complex (GpppN..)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433091", "map_id": "none", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10433136", "map_id": "none", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10479695", "map_id": "none", "name": "LIPC dimer binds heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1604784", "map_id": "CHEBI:24505", "name": "Heparins", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10478382", "map_id": "none", "name": "LIPC dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10478384", "map_id": "none", "name": "LIPC dimer:heparin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10479623", "map_id": "none", "name": "HSPG binds LPL dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10479619", "map_id": "none", "name": "LPL dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_1678620", "map_id": "CHEBI:24499", "name": "HSPG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10479621", "map_id": "none", "name": "HSPG:LPL dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10478387", "map_id": "none", "name": "LIPC dimer hydrolyses TAG to DAG and FA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_422024", "map_id": "CHEBI:35366", "name": "FAs", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10435351", "map_id": "none", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10435285", "map_id": "none", "name": "Homologues of SERPINC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_9693058", "map_id": "none", "name": "SERPINC1 activators", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10435349", "map_id": "none", "name": "SERPINC1:SERPINC1 activators", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10472771", "map_id": "none", "name": "SERPINA5 binds activated protein C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10472753", "map_id": "none", "name": "Homologues of SERPINA5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10472767", "map_id": "none", "name": "Activated protein C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A1ZAG9", "map_id": "A1ZAG9", "name": "phospho-HDC06756", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053459", "map_id": "FBgn0053459", "name": "phospho-HDC06756", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAG8", "map_id": "A1ZAG8", "name": "phospho-Dmel\\CG33458", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053458", "map_id": "FBgn0053458", "name": "phospho-Dmel\\CG33458", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472769", "map_id": "none", "name": "SERPINA5:Activated protein C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_977180", "map_id": "CHEBI:18085", "name": "GAG", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10496558", "map_id": "none", "name": "Factor Xa inhibitors binds Xa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_9038743", "map_id": "none", "name": "Factor Xa inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10496554", "map_id": "none", "name": "factor Xa", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10496556", "map_id": "none", "name": "factor Xa:Factor Xa inhibitors", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10465672", "map_id": "none", "name": "VTN binds Plasminogen activator inhibitor- 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443474", "map_id": "O46099", "name": "EG:8D8.2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "FBgn0024366", "map_id": "FBgn0024366", "name": "EG:8D8.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10452309", "map_id": "none", "name": "Homologues of SERPINE1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10465670", "map_id": "none", "name": "Vitronectin:Plasminogen activator inhibitor 1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O46099", "map_id": "O46099", "name": "EG:8D8.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466600", "map_id": "none", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10465757", "map_id": "none", "name": "Tenascins C, R, (X, N)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10466598", "map_id": "none", "name": "Tenascins C, R, (X, N):Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10465811", "map_id": "none", "name": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10443447", "map_id": "none", "name": "Integrin alphaVbeta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10465809", "map_id": "none", "name": "VTN:Integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, alpha2bbeta3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10465968", "map_id": "none", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10465960", "map_id": "Q24567", "name": "NetA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10465964", "map_id": "none", "name": "Beta amyloid fibril", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10465966", "map_id": "none", "name": "AGRN:Beta amyloid fibril", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10462495", "map_id": "none", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10462488", "map_id": "none", "name": "Lysyl hydroxylases:Lysyl hydroxylase procollagen substrates", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VTH0", "map_id": "Q9VTH0", "name": "Plod", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036147", "map_id": "FBgn0036147", "name": "Plod", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1650779", "map_id": "CHEBI:16810", "name": "2OG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_1650769", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_159751", "map_id": "CHEBI:16526", "name": "CO2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10462492", "map_id": "none", "name": "Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10462486", "map_id": "none", "name": "Lysyl hydroxylases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10462527", "map_id": "none", "name": "Glucosylation of collagen propeptide hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10462517", "map_id": "none", "name": "PLOD3:Fe2+ dimer:Galactosyl-hydroxylysyl collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10462524", "map_id": "none", "name": "PLOD3:Fe2+ dimer:Glucosyl-galactosyl-hydroxylysyl collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10462484", "map_id": "none", "name": "PLOD3:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10462555", "map_id": "none", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10462529", "map_id": "Q9VEP4", "name": "Dmel\\CG5225", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10462553", "map_id": "none", "name": "C-linked procollagen type XXVIII trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10493353", "map_id": "none", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10462830", "map_id": "Q9VEP4", "name": "Dmel\\CG5225", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10462854", "map_id": "none", "name": "C-linked procollagen type XXIV trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10462622", "map_id": "none", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10462581", "map_id": "none", "name": "Procollagen type XXIV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10462607", "map_id": "none", "name": "Procollagen type XXIV -N", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10462619", "map_id": "none", "name": "Homologues of BMP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10462520", "map_id": "none", "name": "Galactosylation of collagen propeptide hydroxylysines by PLOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1981137", "map_id": "CHEBI:18307", "name": "UDP-Gal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10462515", "map_id": "none", "name": "PLOD3:Fe2+ dimer:Lysyl hydroxylated collagen propeptides", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10462629", "map_id": "none", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10462513", "map_id": "none", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10462506", "map_id": "none", "name": "COLGALT1,COLGALT2:Lysyl hydroxylated collagen propeptides", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q8IPK4", "map_id": "Q8IPK4", "name": "COLGALT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051915", "map_id": "FBgn0051915", "name": "COLGALT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10462510", "map_id": "none", "name": "COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10443439", "map_id": "none", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443380", "map_id": "none", "name": "Integrin alpha3beta1, alpha6beta4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10443435", "map_id": "none", "name": "Laminins-332, 511, 521, (211, 221)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10443437", "map_id": "none", "name": "Integrin alpha3beta1, alpha6beta4:Laminins-332, 511, 521, (211, 221)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469164", "map_id": "none", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10469158", "map_id": "none", "name": "Integrin alpha6beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10469160", "map_id": "none", "name": "Laminin-211, 221, 332, 411, 512, 521", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10469162", "map_id": "none", "name": "Integrin alpha6beta1:Laminin-211, 221, 332, 411, 512, 521", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10443932", "map_id": "none", "name": "Integrin alpha2beta1 binds laminin-332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443928", "map_id": "none", "name": "Integrin alpha2beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10443930", "map_id": "none", "name": "Integrin alpha2beta1:Laminin-332", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10443465", "map_id": "none", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443459", "map_id": "none", "name": "Integrin alpha7beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10443461", "map_id": "none", "name": "Laminin-211, 221, 411, 512, 521", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10443463", "map_id": "none", "name": "Integrin alpha7beta1:Laminin-211, 221, 411, 512, 521", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466975", "map_id": "none", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10463847", "map_id": "P49415", "name": "Sdc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10466971", "map_id": "none", "name": "Integrin alpha2beta1, (alpha6beta4)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10466973", "map_id": "none", "name": "Syndecan-1:Integrin alpha2beta1 (alpha6beta4)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466987", "map_id": "none", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10466985", "map_id": "none", "name": "Syndecan-1:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466983", "map_id": "none", "name": "Syndecans 1, 2 & 4 bind VTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10466981", "map_id": "none", "name": "Syndecan-1, 2 & 4:VTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10467077", "map_id": "none", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10467073", "map_id": "none", "name": "Syndecan-4:PI(4,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10467075", "map_id": "none", "name": "Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466979", "map_id": "none", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10437858", "map_id": "none", "name": "Homologues of TGFB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10463849", "map_id": "P49415", "name": "Sdc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10466977", "map_id": "none", "name": "Syndecans 2, (4):TGFB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10443455", "map_id": "none", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443449", "map_id": "none", "name": "Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10443453", "map_id": "none", "name": "Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498486", "map_id": "none", "name": "ITGA4:ITGB1 binds natalizumab", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_9679737", "map_id": "none", "name": "natalizumab", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10441036", "map_id": "none", "name": "ITGA4:ITGB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10498484", "map_id": "none", "name": "ITGA4:ITGB1:natalizumab", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10469592", "map_id": "none", "name": "LUM (lumican) binds integrin alpha2beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10469588", "map_id": "M9MSI4", "name": "DS05899.7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10469590", "map_id": "none", "name": "LUM:Integrin alpha2beta1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10443635", "map_id": "none", "name": "Interaction of integrin alphaEbeta7 with Cadherin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10443631", "map_id": "none", "name": "Integrin alphaEbeta7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10443633", "map_id": "none", "name": "Integrin alphaEbeta7:Cadherin-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10465779", "map_id": "none", "name": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10465761", "map_id": "none", "name": "COMP pentamer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10465777", "map_id": "none", "name": "COMP pentamer:Integrin alpha5beta1, Integrin alphaVbeta3, CD47", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10443648", "map_id": "none", "name": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443642", "map_id": "none", "name": "THBS1 trimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10443644", "map_id": "none", "name": "Integrin alpha3beta1, alpha4beta1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10443646", "map_id": "none", "name": "Integrin alpha3beta1, alpha4beta1:THBS1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10465638", "map_id": "none", "name": "LTBP4 binds TGF-Beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10465600", "map_id": "none", "name": "TGF-beta-1:LAP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10465570", "map_id": "none", "name": "Homologues of LTBP4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "P98163", "map_id": "P98163", "name": "phospho-yl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004649", "map_id": "FBgn0004649", "name": "phospho-yl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4B8", "map_id": "Q9V4B8", "name": "phospho-CT7856", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051999", "map_id": "FBgn0051999", "name": "phospho-CT7856", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10465636", "map_id": "none", "name": "LTBP4:TGF-beta-1:LAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10465606", "map_id": "none", "name": "Latent TGF-beta-1 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10465602", "map_id": "none", "name": "LAP1 binding-integrins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10465604", "map_id": "none", "name": "TGF-beta-1:LAP1:LAP1-binding integrins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10465668", "map_id": "none", "name": "Latent TGF-beta-3 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10465628", "map_id": "none", "name": "TGF-beta-3:LAP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10465666", "map_id": "none", "name": "TGF-beta-3:LAP3:LAP3-binding integrins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10465634", "map_id": "none", "name": "LTBP1, LTBP3 bind TGF-Beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10465608", "map_id": "none", "name": "LTBP1, LTBP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10465630", "map_id": "none", "name": "TGF betas:LAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10465632", "map_id": "none", "name": "LTBP1, LTBP3:TGF betas:LAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10489074", "map_id": "none", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489064", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A8JRD0", "map_id": "A8JRD0", "name": "LpR1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0066101", "map_id": "FBgn0066101", "name": "LpR1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489072", "map_id": "none", "name": "VLDL:PCSK9:Clathrin:AP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10493840", "map_id": "none", "name": "RUNX3 binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489801", "map_id": "M9PI08", "name": "RunxA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10493838", "map_id": "none", "name": "RUNX3:TP53 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10491733", "map_id": "none", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491729", "map_id": "P28167", "name": "zfh2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0004607", "map_id": "FBgn0004607", "name": "zfh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491731", "map_id": "none", "name": "RUNX3:ZFHX3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P28167", "map_id": "P28167", "name": "zfh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491740", "map_id": "none", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491736", "map_id": "none", "name": "p-2S-SMAD3:p-2S-SMAD3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10491738", "map_id": "none", "name": "RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10436609", "map_id": "none", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10436603", "map_id": "none", "name": "AMPK heterotrimer (inactive)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10436607", "map_id": "none", "name": "AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10489849", "map_id": "none", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489819", "map_id": "Q9VC96", "name": "BRWD3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0011785", "map_id": "FBgn0011785", "name": "BRWD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489827", "map_id": "P02299", "name": "phospho-His3:CG33845", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10489847", "map_id": "none", "name": "BRWD1:AcK(9,14,18,79)-p(S10,T11)-histone H3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VC96", "map_id": "Q9VC96", "name": "BRWD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489823", "map_id": "none", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467677", "map_id": "P25439", "name": "brm", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0000212", "map_id": "FBgn0000212", "name": "brm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489821", "map_id": "none", "name": "BRWD1:SMARCA4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P25439", "map_id": "P25439", "name": "brm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454519", "map_id": "none", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10454427", "map_id": "none", "name": "p-Y701-STAT1-1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10454513", "map_id": "none", "name": "p-Y701-STAT1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10454517", "map_id": "none", "name": "p-STAT1 dimer:KPNA1:KPNB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O76521", "map_id": "O76521", "name": "Kap-alpha1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024889", "map_id": "FBgn0024889", "name": "Kap-alpha1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454155", "map_id": "none", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10454149", "map_id": "none", "name": "IFNG-activated factor (GAF)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496089", "map_id": "none", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8983696", "map_id": "none", "name": "2'-5' oligoadenylate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10496086", "map_id": "Q8IP91", "name": "d3635", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0051759", "map_id": "FBgn0051759", "name": "d3635", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461341", "map_id": "none", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10461329", "map_id": "none", "name": "ISGylated 4EHP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94981", "map_id": "Q94981", "name": "ari-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017418", "map_id": "FBgn0017418", "name": "ari-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZ73", "map_id": "Q9VZ73", "name": "Dmel\\CG17030", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035584", "map_id": "FBgn0035584", "name": "Dmel\\CG17030", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K738", "map_id": "Q7K738", "name": "Ubc10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026316", "map_id": "FBgn0026316", "name": "Ubc10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52487", "map_id": "P52487", "name": "Ubc84D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017456", "map_id": "FBgn0017456", "name": "Ubc84D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JIV5", "map_id": "E1JIV5", "name": "eIF4EHP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053100", "map_id": "FBgn0053100", "name": "eIF4EHP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10461337", "map_id": "none", "name": "eIF4F:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10461335", "map_id": "none", "name": "EIF4F", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10461339", "map_id": "none", "name": "ISGylated 4EHP:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10453068", "map_id": "none", "name": "PXLP-K341-GPT2 transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10453063", "map_id": "none", "name": "PXLP-K341-GPT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VYD9", "map_id": "Q9VYD9", "name": "ALT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030478", "map_id": "FBgn0030478", "name": "ALT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428164", "map_id": "none", "name": "PXLP-K314-GPT transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428159", "map_id": "none", "name": "PXLP-K314-GPT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10443038", "map_id": "none", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10443035", "map_id": "none", "name": "Empty Glutamate Synaptic Vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VQC0", "map_id": "Q9VQC0", "name": "VGlut", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P21521", "map_id": "P21521", "name": "Syt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004242", "map_id": "FBgn0004242", "name": "Syt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25228", "map_id": "P25228", "name": "Rab3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005586", "map_id": "FBgn0005586", "name": "Rab3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10442948", "map_id": "none", "name": "Glutamate loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10442860", "map_id": "none", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10442858", "map_id": "Q9VJ59", "name": "Jwa", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0032704", "map_id": "FBgn0032704", "name": "Jwa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428262", "map_id": "none", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113522", "map_id": "CHEBI:58359", "name": "L-Gln", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113561", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428259", "map_id": "none", "name": "GLS dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q1RL13", "map_id": "Q1RL13", "name": "GLS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261625", "map_id": "FBgn0261625", "name": "GLS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10443028", "map_id": "none", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443005", "map_id": "none", "name": "Docked Glutamate Loaded Synaptic Vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8IPM8", "map_id": "Q8IPM8", "name": "cpx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041605", "map_id": "FBgn0041605", "name": "cpx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "H9XVP2", "map_id": "H9XVP2", "name": "unc-13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025726", "map_id": "FBgn0025726", "name": "unc-13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PE32", "map_id": "M9PE32", "name": "Fife", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264606", "map_id": "FBgn0264606", "name": "Fife", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P36975", "map_id": "P36975", "name": "Snap25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011288", "map_id": "FBgn0011288", "name": "Snap25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH76", "map_id": "Q9VH76", "name": "Snap24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266720", "map_id": "FBgn0266720", "name": "Snap24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q07327", "map_id": "Q07327", "name": "Rop", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004574", "map_id": "FBgn0004574", "name": "Rop", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24547", "map_id": "Q24547", "name": "Syx1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013343", "map_id": "FBgn0013343", "name": "Syx1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10443025", "map_id": "P25228", "name": "Rab3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10443011", "map_id": "Q9VQC0", "name": "VGlut", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10442919", "map_id": "Q07327", "name": "Rop", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10443003", "map_id": "none", "name": "RIMS1:UNC13B:BZRAP1:Alpha-liprin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10442973", "map_id": "Q8IPM8", "name": "cpx", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10443021", "map_id": "none", "name": "SNARE complex:Ca2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10443023", "map_id": "P21521", "name": "Syt1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10443008", "map_id": "none", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442978", "map_id": "Q24547", "name": "Syx1A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10442968", "map_id": "none", "name": "Homologues of SNAP25", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10442988", "map_id": "H9XVP2", "name": "unc-13", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10480942", "map_id": "none", "name": "GADD45A binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10480938", "map_id": "Q9VGF9", "name": "aurA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10480365", "map_id": "A1Z6W5", "name": "Gadd45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0033153", "map_id": "FBgn0033153", "name": "Gadd45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10480940", "map_id": "none", "name": "GADD45A:AURKA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A1Z6W5", "map_id": "A1Z6W5", "name": "Gadd45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10485962", "map_id": "none", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432002", "map_id": "none", "name": "SFN dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10485960", "map_id": "none", "name": "SFN Dimer:CCNB1:CDK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10485964", "map_id": "none", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432000", "map_id": "P29310", "name": "14-3-3zeta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10480369", "map_id": "none", "name": "GADD45A binds PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10480367", "map_id": "none", "name": "GADD45A:PCNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432502", "map_id": "none", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_75973", "map_id": "CHEBI:17197", "name": "GO3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_390422", "map_id": "CHEBI:63818", "name": "HXDG3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10432499", "map_id": "Q9Y140", "name": "DHRS7B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "FBgn0027583", "map_id": "FBgn0027583", "name": "DHRS7B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498530", "map_id": "none", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9648300", "map_id": "none", "name": "chlorpromazine", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10489943", "map_id": "none", "name": "AP2:chlorpromazine", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10489892", "map_id": "none", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10489882", "map_id": "none", "name": "UBQLN2,1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IPM2", "map_id": "Q8IPM2", "name": "Dmel\\CG31528", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051528", "map_id": "FBgn0051528", "name": "Dmel\\CG31528", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHX2", "map_id": "Q9VHX2", "name": "Dmel\\CG3223", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037538", "map_id": "FBgn0037538", "name": "Dmel\\CG3223", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWD9", "map_id": "Q9VWD9", "name": "Ubqn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031057", "map_id": "FBgn0031057", "name": "Ubqn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489888", "map_id": "none", "name": "EPS15,EPN1,EPN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10489890", "map_id": "none", "name": "UNQLNs:UIM proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10489638", "map_id": "none", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10489614", "map_id": "none", "name": "TOR1 hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O77277", "map_id": "O77277", "name": "Torsin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025615", "map_id": "FBgn0025615", "name": "Torsin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489598", "map_id": "Q24212", "name": "stnB", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0016975", "map_id": "FBgn0016975", "name": "stnB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489634", "map_id": "none", "name": "COP9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10489636", "map_id": "none", "name": "NEDD8-STONs:TOR1 hexamer:COP9", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q24212", "map_id": "Q24212", "name": "stnB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489576", "map_id": "none", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489560", "map_id": "P98081", "name": "Dab", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0000414", "map_id": "FBgn0000414", "name": "Dab", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489572", "map_id": "none", "name": "Homologues of LRP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q5BIG2", "map_id": "Q5BIG2", "name": "Dmel\\CG6024", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036202", "map_id": "FBgn0036202", "name": "Dmel\\CG6024", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JTM7", "map_id": "A8JTM7", "name": "mgl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261260", "map_id": "FBgn0261260", "name": "mgl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489574", "map_id": "none", "name": "LRP2:DAB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P98081", "map_id": "P98081", "name": "Dab", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489641", "map_id": "none", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477764", "map_id": "Q9VJ33", "name": "Nedd8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0032725", "map_id": "FBgn0032725", "name": "Nedd8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489552", "map_id": "Q24212", "name": "stnB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10489963", "map_id": "none", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489959", "map_id": "none", "name": "ubiquitinated cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8MQS4", "map_id": "Q8MQS4", "name": "Reps", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032341", "map_id": "FBgn0032341", "name": "Reps", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489961", "map_id": "none", "name": "EPS15,EPN1,EPN2:ubiquitinated cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10489643", "map_id": "none", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10489969", "map_id": "none", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489853", "map_id": "none", "name": "ARRB:ARRB-binding GPCRs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10489365", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VXB0", "map_id": "Q9VXB0", "name": "NECAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030791", "map_id": "FBgn0030791", "name": "NECAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6AWD5", "map_id": "Q6AWD5", "name": "Dmel\\CG8176", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037702", "map_id": "FBgn0037702", "name": "Dmel\\CG8176", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ30", "map_id": "Q9VJ30", "name": "Nak", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015772", "map_id": "FBgn0015772", "name": "Nak", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489965", "map_id": "none", "name": "ARBBs:ARBB-binding GPCRs:clathrin-coated pit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10489967", "map_id": "none", "name": "UBQLN2:UIM-containing proteins", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10490099", "map_id": "none", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490093", "map_id": "Q9VI75", "name": "lap", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0086372", "map_id": "FBgn0086372", "name": "lap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10490091", "map_id": "none", "name": "VAMP2,3,8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10490097", "map_id": "none", "name": "PICALM:VAMP2,3,8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VI75", "map_id": "Q9VI75", "name": "lap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489558", "map_id": "none", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489547", "map_id": "none", "name": "SYT dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VUJ3", "map_id": "Q9VUJ3", "name": "Sytbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261090", "map_id": "FBgn0261090", "name": "Sytbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489556", "map_id": "none", "name": "STON2,1:SYT dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10489945", "map_id": "none", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489939", "map_id": "none", "name": "AP-2 cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q27367", "map_id": "Q27367", "name": "crq", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015924", "map_id": "FBgn0015924", "name": "crq", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O17444", "map_id": "O17444", "name": "VAChT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0270928", "map_id": "FBgn0270928", "name": "VAChT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSC9", "map_id": "Q9VSC9", "name": "Dmel\\CG7565", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035833", "map_id": "FBgn0035833", "name": "Dmel\\CG7565", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489941", "map_id": "none", "name": "AP-2:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10489595", "map_id": "none", "name": "AGFG1 binds VAMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489591", "map_id": "Q7JYX5", "name": "Vamp7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0266186", "map_id": "FBgn0266186", "name": "Vamp7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489589", "map_id": "E1JHR0", "name": "drongo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0020304", "map_id": "FBgn0020304", "name": "drongo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489593", "map_id": "none", "name": "AGFG1:VAMP7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "E1JHR0", "map_id": "E1JHR0", "name": "drongo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JYX5", "map_id": "Q7JYX5", "name": "Vamp7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489855", "map_id": "none", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489851", "map_id": "none", "name": "ARRB-binding GPCRs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10474367", "map_id": "none", "name": "ARRB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10484330", "map_id": "none", "name": "CHEK1 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427808", "map_id": "none", "name": "p-S15-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438565", "map_id": "none", "name": "Recruitment and activation of Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438550", "map_id": "O61661", "name": "grp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10438562", "map_id": "none", "name": "ATR:ATRIP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VVN4", "map_id": "Q9VVN4", "name": "mus304", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002901", "map_id": "FBgn0002901", "name": "mus304", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXG8", "map_id": "Q9VXG8", "name": "mei-41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004367", "map_id": "FBgn0004367", "name": "mei-41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432380", "map_id": "none", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10431972", "map_id": "none", "name": "Homologues of CDC25C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10431980", "map_id": "none", "name": "Homologues of p-S216-CDC25C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497068", "map_id": "none", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10498000", "map_id": "none", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10497993", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10497997", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10498113", "map_id": "none", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10497982", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10497986", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10498111", "map_id": "none", "name": "FLCN:FNIP1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VS33", "map_id": "Q9VS33", "name": "BHD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261111", "map_id": "FBgn0261111", "name": "BHD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E3CTN7", "map_id": "E3CTN7", "name": "CG3764-RA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036684", "map_id": "FBgn0036684", "name": "CG3764-RA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498116", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10497995", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10498002", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10497989", "map_id": "none", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "reaction_10498009", "map_id": "none", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10498004", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10498006", "map_id": "none", "name": "v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10498124", "map_id": "none", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "reaction_10437161", "map_id": "none", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10437154", "map_id": "none", "name": "FA anion:UCP dimer \"head-out\" complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q7K566", "map_id": "Q7K566", "name": "Bmcp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036199", "map_id": "FBgn0036199", "name": "Bmcp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX14", "map_id": "Q9VX14", "name": "Ucp4A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030872", "map_id": "FBgn0030872", "name": "Ucp4A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_166213", "map_id": "CHEBI:28868", "name": "Fatty Acid anion \"head-in\"", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_166216", "map_id": "CHEBI:28868", "name": "Fatty Acid anion \"head-out\"", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10437150", "map_id": "none", "name": "UCP dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10437159", "map_id": "none", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10437152", "map_id": "none", "name": "FA anion:UCP dimer \"head-in\" complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10437157", "map_id": "none", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "reaction_10437560", "map_id": "none", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_30495", "map_id": "CHEBI:15904", "name": "LCFA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_170037", "map_id": "none", "name": "Purine nucleotide", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10442079", "map_id": "none", "name": "Caspase mediated cleavage of C-IAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442065", "map_id": "none", "name": "Homologues of BIRC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10442071", "map_id": "none", "name": "Homologues of BIRC2(1-372)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10442077", "map_id": "none", "name": "Homologues of BIRC2(373-618)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10434841", "map_id": "none", "name": "Caspase-3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497056", "map_id": "none", "name": "Caspase-7 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434869", "map_id": "none", "name": "Caspase-7", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VET9", "map_id": "Q9VET9", "name": "Decay", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028381", "map_id": "FBgn0028381", "name": "Decay", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444173", "map_id": "none", "name": "active caspase-7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10441599", "map_id": "none", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441593", "map_id": "Q02645", "name": "hts", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441595", "map_id": "Q02645", "name": "hts", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441597", "map_id": "Q02645", "name": "hts", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10442090", "map_id": "none", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442086", "map_id": "Q9VU84", "name": "Abp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442088", "map_id": "Q9VU84", "name": "Abp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441658", "map_id": "none", "name": "Caspase-mediated cleavage of plectin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441645", "map_id": "A1Z9J3", "name": "shot", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441647", "map_id": "A1Z9J3", "name": "shot", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441655", "map_id": "none", "name": "active caspase-8 ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O01382", "map_id": "O01382", "name": "Drice", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019972", "map_id": "FBgn0019972", "name": "Drice", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10442101", "map_id": "none", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442095", "map_id": "P13395", "name": "alpha-Spec", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442097", "map_id": "P13395", "name": "alpha-Spec", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442099", "map_id": "P13395", "name": "alpha-Spec", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441621", "map_id": "none", "name": "Caspase-mediated cleavage of Tau", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441615", "map_id": "Q9VB15", "name": "tau", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0266579", "map_id": "FBgn0266579", "name": "tau", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441617", "map_id": "Q9VB15", "name": "tau", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441619", "map_id": "Q9VB15", "name": "tau", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10443560", "map_id": "none", "name": "Caspase-mediated cleavage of Lamin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10443537", "map_id": "none", "name": "Homologues of Lamin A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10443543", "map_id": "none", "name": "Homologues of LMNA(231-664)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_10443549", "map_id": "none", "name": "Homologues of LMNA(1-230)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "species_10443557", "map_id": "none", "name": "active caspase-6", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497066", "map_id": "none", "name": "Caspase-6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10497064", "map_id": "none", "name": "active caspase-6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10443568", "map_id": "none", "name": "Caspase-mediated cleavage of Lamin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10443562", "map_id": "P08928", "name": "Lam", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10443564", "map_id": "P08928", "name": "Lam", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "species_10443566", "map_id": "P08928", "name": "Lam", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "false" }, { "id": "reaction_10444150", "map_id": "none", "name": "Caspase mediated cleavage of BAP31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10444141", "map_id": "Q9W0M4", "name": "Dmel\\CG13887", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0035165", "map_id": "FBgn0035165", "name": "Dmel\\CG13887", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444145", "map_id": "Q9W0M4", "name": "Dmel\\CG13887", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10444147", "map_id": "Q9W0M4", "name": "Dmel\\CG13887", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444143", "map_id": "Q9W0M4", "name": "Dmel\\CG13887", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10444126", "map_id": "none", "name": "active caspase-8 ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10444118", "map_id": "none", "name": "Caspase-mediated cleavage of Etk", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444112", "map_id": "P08630", "name": "Btk29A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0003502", "map_id": "FBgn0003502", "name": "Btk29A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444114", "map_id": "P08630", "name": "Btk29A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444116", "map_id": "P08630", "name": "Btk29A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441588", "map_id": "none", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441584", "map_id": "P83099", "name": "Pkcdelta", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441586", "map_id": "P83099", "name": "Pkcdelta", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10443314", "map_id": "none", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434441", "map_id": "P83099", "name": "Pkcdelta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10443312", "map_id": "P83099", "name": "Pkcdelta", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10443310", "map_id": "P83099", "name": "Pkcdelta", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10444176", "map_id": "none", "name": "Caspase-mediated cleavage of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438600", "map_id": "Q8IRB5", "name": "Claspin", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0052251", "map_id": "FBgn0052251", "name": "Claspin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444163", "map_id": "Q8IRB5", "name": "Claspin", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10444165", "map_id": "Q8IRB5", "name": "Claspin", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10444238", "map_id": "none", "name": "Cleavage of Satb1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10444234", "map_id": "Q9W268", "name": "dve", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10444236", "map_id": "Q9W268", "name": "dve", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10442059", "map_id": "none", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442045", "map_id": "none", "name": "Homologues of APC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10442051", "map_id": "none", "name": "Homologues of APC(1-777)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10442057", "map_id": "none", "name": "Homologues of APC(778-2843)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10441610", "map_id": "none", "name": "Caspase-mediated cleavage of Rock-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441606", "map_id": "Q9VXE3", "name": "Rok", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441608", "map_id": "Q9VXE3", "name": "Rok", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441669", "map_id": "none", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441663", "map_id": "Q9VR31", "name": "Fnta", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441665", "map_id": "Q9VR31", "name": "Fnta", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441667", "map_id": "Q9VR31", "name": "Fnta", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10444035", "map_id": "none", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444029", "map_id": "Q9VEN3", "name": "GckIII", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0266465", "map_id": "FBgn0266465", "name": "GckIII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444033", "map_id": "Q9VEN3", "name": "GckIII", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444031", "map_id": "Q9VEN3", "name": "GckIII", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10444161", "map_id": "none", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444152", "map_id": "Q9VEN3", "name": "GckIII", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444154", "map_id": "Q9VEN3", "name": "GckIII", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444156", "map_id": "Q9VEN3", "name": "GckIII", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444158", "map_id": "none", "name": "Caspase-3, Caspase-7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10442109", "map_id": "none", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442103", "map_id": "none", "name": "beta-catenin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442105", "map_id": "P18824", "name": "arm", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442107", "map_id": "P18824", "name": "arm", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10441580", "map_id": "none", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10441575", "map_id": "Q7PLI0", "name": "p120ctn", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10441577", "map_id": "Q7PLI0", "name": "p120ctn", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10441641", "map_id": "none", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441637", "map_id": "A1Z9J3", "name": "shot", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10441639", "map_id": "A1Z9J3", "name": "shot", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10444136", "map_id": "none", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444130", "map_id": "Q9VW51", "name": "Ell", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0014037", "map_id": "FBgn0014037", "name": "Ell", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444132", "map_id": "Q9VW51", "name": "Ell", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10444134", "map_id": "Q9VW51", "name": "Ell", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10442039", "map_id": "none", "name": "Caspase-mediated cleavage of E-Cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442035", "map_id": "Q9VJB6", "name": "CadN2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10442037", "map_id": "Q9VJB6", "name": "CadN2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10441632", "map_id": "none", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441626", "map_id": "Q9VJ12", "name": "Acn", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0263198", "map_id": "FBgn0263198", "name": "Acn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441628", "map_id": "Q9VJ12", "name": "Acn", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441630", "map_id": "Q9VJ12", "name": "Acn", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10444189", "map_id": "none", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444185", "map_id": "Q9VQE0", "name": "Drp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0026479", "map_id": "FBgn0026479", "name": "Drp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444187", "map_id": "Q9VQE0", "name": "Drp1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10444180", "map_id": "none", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10444178", "map_id": "Q9VEN3", "name": "GckIII", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10443148", "map_id": "none", "name": "Translocation of DFF to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10443134", "map_id": "none", "name": "DFF:associated with the importin-alpha:importin-beta complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V3H0", "map_id": "Q9V3H0", "name": "Drep4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028406", "map_id": "FBgn0028406", "name": "Drep4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10443146", "map_id": "none", "name": "DFF:associated with the importin-alpha:importin-beta complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10443158", "map_id": "none", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10443156", "map_id": "none", "name": "active caspase-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10443126", "map_id": "none", "name": "Homodimerization of DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10443122", "map_id": "Q9V3H0", "name": "Drep4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10443124", "map_id": "none", "name": "DFF40 homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10443924", "map_id": "none", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10443920", "map_id": "none", "name": "HMGB1/HMGB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q24537", "map_id": "Q24537", "name": "Dsp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Dsp1", "map_id": "Dsp1", "name": "Dsp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JIT5", "map_id": "E1JIT5", "name": "tHMG2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038979", "map_id": "FBgn0038979", "name": "tHMG2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCZ5", "map_id": "Q9VCZ5", "name": "tHMG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038978", "map_id": "FBgn0038978", "name": "tHMG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q05783", "map_id": "Q05783", "name": "HmgD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004362", "map_id": "FBgn0004362", "name": "HmgD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10443922", "map_id": "none", "name": "HMGB1/HMGB2- bound chromatin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10444128", "map_id": "none", "name": "Translocation of active caspase-8 to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10444436", "map_id": "none", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444433", "map_id": "none", "name": "Homologues of DCC(26-1290)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444427", "map_id": "none", "name": "Homologues of DCC(1291-1447)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497776", "map_id": "none", "name": "SEPT4 binds XIAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497772", "map_id": "none", "name": "SEPT4 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q0KHR7", "map_id": "Q0KHR7", "name": "Sep4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259923", "map_id": "FBgn0259923", "name": "Sep4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434883", "map_id": "none", "name": "Homologues of XIAP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10497774", "map_id": "none", "name": "SEPT4 dimer:XIAP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497768", "map_id": "none", "name": "XIAP binds CASP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497766", "map_id": "none", "name": "XIAP:Caspase-3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497770", "map_id": "none", "name": "XIAP binds CASP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434885", "map_id": "none", "name": "XIAP:Caspase-7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10486228", "map_id": "none", "name": "Release of SEPT4 from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486224", "map_id": "Q0KHR7", "name": "Sep4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10486226", "map_id": "Q0KHR7", "name": "Sep4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10434873", "map_id": "none", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10434871", "map_id": "P84029", "name": "Cyt-c-p", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10434846", "map_id": "P84029", "name": "Cyt-c-p", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433151", "map_id": "none", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77255", "map_id": "CHEBI:15471", "name": "2-trans-Dodecenoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77252", "map_id": "CHEBI:27668", "name": "(S)-3-Hydroxydodecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433190", "map_id": "none", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77253", "map_id": "CHEBI:27868", "name": "3-Oxododecanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10468301", "map_id": "none", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468296", "map_id": "P02283", "name": "His2B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10468772", "map_id": "none", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468720", "map_id": "none", "name": "Histone H2A, H2B, H3, H4", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10468769", "map_id": "none", "name": "AcK-histone H2A, H2B, H3, H4", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10472691", "map_id": "none", "name": "NCOA1(868-1441) binds PAX3(1-319)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10472670", "map_id": "M9ND53", "name": "tai", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10472687", "map_id": "none", "name": "Homologues of PAX3 (1-319)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P09083", "map_id": "P09083", "name": "gsb-n", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001147", "map_id": "FBgn0001147", "name": "gsb-n", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P09082", "map_id": "P09082", "name": "gsb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001148", "map_id": "FBgn0001148", "name": "gsb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P06601", "map_id": "P06601", "name": "prd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003145", "map_id": "FBgn0003145", "name": "prd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472689", "map_id": "none", "name": "NCOA1(868-1441):PAX3(1-319)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10441327", "map_id": "none", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441315", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "A1Z784", "map_id": "A1Z784", "name": "phospho-ACC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441322", "map_id": "none", "name": "Btn-p-S79-ACACB:2Mn2+ polymer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10441324", "map_id": "none", "name": "AMPK heterotrimer (active)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10436920", "map_id": "none", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10436917", "map_id": "none", "name": "Homologues of SLC22A5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10441335", "map_id": "none", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_201023", "map_id": "CHEBI:17126", "name": "CAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_201050", "map_id": "CHEBI:17490", "name": "L-PCARN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10441332", "map_id": "Q9VQG4", "name": "colt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0019830", "map_id": "FBgn0019830", "name": "colt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10441286", "map_id": "none", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_77281", "map_id": "CHEBI:15525", "name": "PalmCoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10441283", "map_id": "Q9VZW7", "name": "CPT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0035383", "map_id": "FBgn0035383", "name": "CPT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490057", "map_id": "none", "name": "MID1IP1 binds THRSP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432448", "map_id": "Q9W0X5", "name": "Dmel\\CG2765", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035087", "map_id": "FBgn0035087", "name": "Dmel\\CG2765", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432446", "map_id": "Q9W0X5", "name": "Dmel\\CG2765", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10432450", "map_id": "none", "name": "MID1IP1:THRSP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W0X5", "map_id": "Q9W0X5", "name": "Dmel\\CG2765", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432452", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432440", "map_id": "none", "name": "Btn-ACACA:2Mn2+ polymer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10491438", "map_id": "none", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10465132", "map_id": "none", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161185", "map_id": "none", "name": "abacavir", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2162081", "map_id": "CHEBI:64192", "name": "abacavir 5'-carboxylic acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10429065", "map_id": "none", "name": "ADH1A:2Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465049", "map_id": "none", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161194", "map_id": "none", "name": "abacavir monophosphate", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161176", "map_id": "none", "name": "carbovir monophosphate", "type": "product", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161175", "map_id": "CHEBI:34660", "name": "cyclopropylamine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465129", "map_id": "none", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161514", "map_id": "none", "name": "carbovir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10469582", "map_id": "none", "name": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_4085390", "map_id": "CHEBI:27438", "name": "Neu5Ac-9-P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469579", "map_id": "none", "name": "NANP:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W481", "map_id": "Q9W481", "name": "Dmel\\CG15771", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029801", "map_id": "FBgn0029801", "name": "Dmel\\CG15771", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469572", "map_id": "none", "name": "NANS converts ManNAc-6-P to Neu5Ac-9-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_4085225", "map_id": "CHEBI:28273", "name": "ManNAc-6-P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10469569", "map_id": "Q9VG74", "name": "NANS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0038045", "map_id": "FBgn0038045", "name": "NANS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469586", "map_id": "none", "name": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_4086285", "map_id": "CHEBI:61248", "name": "Gal-R", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_4086294", "map_id": "CHEBI:75129", "name": "Neu5Ac-2,6-Gal-R", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10475581", "map_id": "none", "name": "NIK autophosphorylates on T559", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475579", "map_id": "Q8MSQ4", "name": "phospho-Mekk1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433321", "map_id": "none", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433315", "map_id": "none", "name": "TFIIIB:TFIIIC:Type 2 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433319", "map_id": "none", "name": "RNA Polymerase III:TFIIIB:TFIIIC:Type 2 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433317", "map_id": "none", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432662", "map_id": "none", "name": "TFIIIB-Type 1 and 2 Promoter Selective Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433311", "map_id": "none", "name": "TFIIIC:Type 2 Promoter Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433313", "map_id": "none", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432691", "map_id": "none", "name": "TFIIIC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_83747", "map_id": "none", "name": "DNA with RNA Polymerase III Type 2 Closed Promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10443033", "map_id": "none", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443030", "map_id": "none", "name": "Astrocytic EAATs", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10428246", "map_id": "none", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428243", "map_id": "none", "name": "GLUL decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P20478", "map_id": "P20478", "name": "Gs2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001145", "map_id": "FBgn0001145", "name": "Gs2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20477", "map_id": "P20477", "name": "Gs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001142", "map_id": "FBgn0001142", "name": "Gs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464591", "map_id": "none", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2046050", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_211579", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5228339", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_2046055", "map_id": "CHEBI:63546", "name": "TPA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_211606", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10446277", "map_id": "Q7JUN3", "name": "ABCD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "reaction_10464593", "map_id": "none", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046066", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046042", "map_id": "CHEBI:15508", "name": "GLA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046045", "map_id": "CHEBI:27979", "name": "DGL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_214880", "map_id": "none", "name": "DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "In dorsoventral patterning in the embryo, Dorsal (DL) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_214746", "map_id": "none", "name": "DL dimer:CACT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_214759", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_214758", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_214857", "map_id": "none", "name": "DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "The Dorsal (DL) and Dorsal-related immunity factor (DIF) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206862", "map_id": "none", "name": "DL/DIF dimer:CACT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206693", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_214744", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10467071", "map_id": "none", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467068", "map_id": "none", "name": "BESTs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VUM6", "map_id": "Q9VUM6", "name": "Best4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036491", "map_id": "FBgn0036491", "name": "Best4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRW4", "map_id": "Q9VRW4", "name": "Best2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035696", "map_id": "FBgn0035696", "name": "Best2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUM7", "map_id": "Q9VUM7", "name": "Best3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036492", "map_id": "FBgn0036492", "name": "Best3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498689", "map_id": "none", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468206", "map_id": "Q9W3W0", "name": "iav", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0086693", "map_id": "FBgn0086693", "name": "iav", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468221", "map_id": "none", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468218", "map_id": "none", "name": "TRPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W3W0", "map_id": "Q9W3W0", "name": "iav", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW35", "map_id": "Q9VW35", "name": "Trpml", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261361", "map_id": "FBgn0261361", "name": "Trpml", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7Z020", "map_id": "Q7Z020", "name": "TrpA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035934", "map_id": "FBgn0035934", "name": "TrpA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYE2", "map_id": "A8DYE2", "name": "Trpm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265194", "map_id": "FBgn0265194", "name": "Trpm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498686", "map_id": "none", "name": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498683", "map_id": "none", "name": "TRPA1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498213", "map_id": "none", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498211", "map_id": "none", "name": "ASIC trimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VJI4", "map_id": "Q9VJI4", "name": "ppk17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032602", "map_id": "FBgn0032602", "name": "ppk17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10466252", "map_id": "none", "name": "ASIC trimers:H+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466969", "map_id": "none", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2730999", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10466966", "map_id": "none", "name": "CLCN7:OSTM1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q7JZ25", "map_id": "Q7JZ25", "name": "ClC-b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033755", "map_id": "FBgn0033755", "name": "ClC-b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95SH7", "map_id": "Q95SH7", "name": "Dmel\\CG14969", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035440", "map_id": "FBgn0035440", "name": "Dmel\\CG14969", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466773", "map_id": "none", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10466770", "map_id": "none", "name": "ANOs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9PI24", "map_id": "M9PI24", "name": "Dmel\\CG6938", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036235", "map_id": "FBgn0036235", "name": "Dmel\\CG6938", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O97132", "map_id": "O97132", "name": "Axs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000152", "map_id": "FBgn0000152", "name": "Axs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V416", "map_id": "Q9V416", "name": "BG:DS04929.1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028879", "map_id": "FBgn0028879", "name": "BG:DS04929.1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466997", "map_id": "none", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10466992", "map_id": "Q9VGH7", "name": "ClC-a", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0051116", "map_id": "FBgn0051116", "name": "ClC-a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466803", "map_id": "none", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2731008", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10466798", "map_id": "Q9VUY1", "name": "ClC-c", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "FBgn0036566", "map_id": "FBgn0036566", "name": "ClC-c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467123", "map_id": "none", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_2889081", "map_id": "none", "name": "Na+/Li+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_2889062", "map_id": "none", "name": "Na+/Li+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10467120", "map_id": "Q9VM74", "name": "Nha1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0031865", "map_id": "FBgn0031865", "name": "Nha1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466257", "map_id": "none", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10466255", "map_id": "Q9VJI4", "name": "ppk17", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_2672379", "map_id": "none", "name": "amiloride", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_2672383", "map_id": "CHEBI:35475", "name": "NSAID", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10467025", "map_id": "none", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467022", "map_id": "Q9U6L4", "name": "tty", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0015558", "map_id": "FBgn0015558", "name": "tty", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489584", "map_id": "none", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489580", "map_id": "none", "name": "STOML3, (STOM)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10489582", "map_id": "none", "name": "ASIC trimers:H+:STOML3,(STOM)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10467118", "map_id": "none", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10467115", "map_id": "Q9VM74", "name": "Nha1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10467020", "map_id": "none", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467017", "map_id": "none", "name": "TTYH2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W5A5", "map_id": "Q9W5A5", "name": "TTYH3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261444", "map_id": "FBgn0261444", "name": "TTYH3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U6L4", "map_id": "Q9U6L4", "name": "tty", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10466793", "map_id": "none", "name": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10466790", "map_id": "none", "name": "NALCN:UNC79:UNC80", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VDY5", "map_id": "Q9VDY5", "name": "unc79", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038693", "map_id": "FBgn0038693", "name": "unc79", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JUW5", "map_id": "A8JUW5", "name": "na", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002917", "map_id": "FBgn0002917", "name": "na", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB11", "map_id": "Q9VB11", "name": "unc80", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039536", "map_id": "FBgn0039536", "name": "unc80", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467080", "map_id": "none", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10466592", "map_id": "none", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10466589", "map_id": "none", "name": "SCNN channels", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W2B5", "map_id": "Q9W2B5", "name": "ppk9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085398", "map_id": "FBgn0085398", "name": "ppk9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W250", "map_id": "Q9W250", "name": "ppk12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034730", "map_id": "FBgn0034730", "name": "ppk12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZN1", "map_id": "Q9VZN1", "name": "ppk27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035458", "map_id": "FBgn0035458", "name": "ppk27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS73", "map_id": "Q9VS73", "name": "ppk26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035785", "map_id": "FBgn0035785", "name": "ppk26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VME9", "map_id": "Q9VME9", "name": "ppk7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031802", "map_id": "FBgn0031802", "name": "ppk7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VME8", "map_id": "Q9VME8", "name": "ppk14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031803", "map_id": "FBgn0031803", "name": "ppk14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL88", "map_id": "Q9VL88", "name": "ppk18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265001", "map_id": "FBgn0265001", "name": "ppk18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL84", "map_id": "Q9VL84", "name": "ppk11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0065109", "map_id": "FBgn0065109", "name": "ppk11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBF6", "map_id": "Q9VBF6", "name": "ppk15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039424", "map_id": "FBgn0039424", "name": "ppk15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAJ7", "map_id": "Q9VAJ7", "name": "ppk21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039675", "map_id": "FBgn0039675", "name": "ppk21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAJ6", "map_id": "Q9VAJ6", "name": "ppk20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039676", "map_id": "FBgn0039676", "name": "ppk20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAJ5", "map_id": "Q9VAJ5", "name": "ppk30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039677", "map_id": "FBgn0039677", "name": "ppk30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAJ3", "map_id": "Q9VAJ3", "name": "ppk19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039679", "map_id": "FBgn0039679", "name": "ppk19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9Y5", "map_id": "Q9V9Y5", "name": "ppk24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039839", "map_id": "FBgn0039839", "name": "ppk24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MLR6", "map_id": "Q8MLR6", "name": "ppk3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050181", "map_id": "FBgn0050181", "name": "ppk3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IMV2", "map_id": "Q8IMV2", "name": "ppk22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051105", "map_id": "FBgn0051105", "name": "ppk22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86LH3", "map_id": "Q86LH3", "name": "ppk6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034489", "map_id": "FBgn0034489", "name": "ppk6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86LH1", "map_id": "Q86LH1", "name": "ppk10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0065110", "map_id": "FBgn0065110", "name": "ppk10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86LG9", "map_id": "Q86LG9", "name": "ppk13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053508", "map_id": "FBgn0053508", "name": "ppk13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86LG7", "map_id": "Q86LG7", "name": "ppk16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0065108", "map_id": "FBgn0065108", "name": "ppk16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q86LG1", "map_id": "Q86LG1", "name": "ppk28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030795", "map_id": "FBgn0030795", "name": "ppk28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTW2", "map_id": "Q7KTW2", "name": "ppk5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053289", "map_id": "FBgn0053289", "name": "ppk5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KT94", "map_id": "Q7KT94", "name": "ppk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020258", "map_id": "FBgn0020258", "name": "ppk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0KHW3", "map_id": "Q0KHW3", "name": "ppk8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052792", "map_id": "FBgn0052792", "name": "ppk8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O61365", "map_id": "O61365", "name": "Nach", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024319", "map_id": "FBgn0024319", "name": "Nach", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JV41", "map_id": "A8JV41", "name": "ppk23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030844", "map_id": "FBgn0030844", "name": "ppk23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JPJ8", "map_id": "A8JPJ8", "name": "ppk31", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051065", "map_id": "FBgn0051065", "name": "ppk31", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYP1", "map_id": "A8DYP1", "name": "ppk29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034965", "map_id": "FBgn0034965", "name": "ppk29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6S4", "map_id": "A1Z6S4", "name": "ppk25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053349", "map_id": "FBgn0053349", "name": "ppk25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489010", "map_id": "none", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10488963", "map_id": "none", "name": "RAB7A:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10489003", "map_id": "none", "name": "RAB7:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10489008", "map_id": "Q9VPL5", "name": "Tbc1d15-17", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031233", "map_id": "FBgn0031233", "name": "Tbc1d15-17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488981", "map_id": "none", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10488970", "map_id": "Q9VGL8", "name": "wkd", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_19363", "compartment_display": "microvillus", "complex": "false" }, { "id": "FBgn0037917", "map_id": "FBgn0037917", "name": "wkd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488977", "map_id": "none", "name": "ARF6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "P40946", "map_id": "P40946", "name": "Arf51F", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013750", "map_id": "FBgn0013750", "name": "Arf51F", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488979", "map_id": "none", "name": "TBC1D10A:ARF6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "Q9VGL8", "map_id": "Q9VGL8", "name": "wkd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488999", "map_id": "none", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10488142", "map_id": "none", "name": "RAB6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O18334", "map_id": "O18334", "name": "Rab6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Rab6", "map_id": "Rab6", "name": "Rab6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488995", "map_id": "A8JNN5", "name": "GAPcenA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035879", "map_id": "FBgn0035879", "name": "GAPcenA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488997", "map_id": "none", "name": "RABGAP1:RAB6:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A8JNN5", "map_id": "A8JNN5", "name": "GAPcenA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488968", "map_id": "none", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10488965", "map_id": "none", "name": "RAB7A:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10488924", "map_id": "none", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10488901", "map_id": "none", "name": "RAB35:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "Q9W5X0", "map_id": "Q9W5X0", "name": "Rab35", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031090", "map_id": "FBgn0031090", "name": "Rab35", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488903", "map_id": "none", "name": "RAB35:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10488922", "map_id": "none", "name": "RAB35 specific TBC RabGAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSM8", "map_id": "Q9VSM8", "name": "GAPsec", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035916", "map_id": "FBgn0035916", "name": "GAPsec", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIH7", "map_id": "Q9VIH7", "name": "sky", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032901", "map_id": "FBgn0032901", "name": "sky", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488990", "map_id": "none", "name": "TBC1D7 binds the TSC1-TSC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488986", "map_id": "Q9VCC4", "name": "TBC1d7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0039158", "map_id": "FBgn0039158", "name": "TBC1d7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488988", "map_id": "none", "name": "TBC1D7:TSC1:TSC2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VCC4", "map_id": "Q9VCC4", "name": "TBC1d7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489038", "map_id": "none", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane" }, { "id": "species_10489028", "map_id": "none", "name": "GGC-RAB4A:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "Q7KY04", "map_id": "Q7KY04", "name": "Rab4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016701", "map_id": "FBgn0016701", "name": "Rab4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489030", "map_id": "none", "name": "GGC-RAB4A:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_10489036", "map_id": "Q9VKV6", "name": "TBC1D16", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0032249", "map_id": "FBgn0032249", "name": "TBC1D16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489022", "map_id": "none", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10489018", "map_id": "Q5BI03", "name": "Dmel\\CG8155", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5683636", "compartment_display": "autophagosome", "complex": "false" }, { "id": "FBgn0034009", "map_id": "FBgn0034009", "name": "Dmel\\CG8155", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476330", "map_id": "Q9W2S2", "name": "Atg8a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "false" }, { "id": "FBgn0052672", "map_id": "FBgn0052672", "name": "Atg8a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489020", "map_id": "none", "name": "TBC1D25:ATG8 homoogues", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "Q9W2S2", "map_id": "Q9W2S2", "name": "Atg8a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5BI03", "map_id": "Q5BI03", "name": "Dmel\\CG8155", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488959", "map_id": "none", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10488927", "map_id": "A1Z9K4", "name": "RN-tre", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "false" }, { "id": "FBgn0020620", "map_id": "FBgn0020620", "name": "RN-tre", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488955", "map_id": "none", "name": "GGA1,2,3:RAB5:GTP:RABGEF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "Q9V3I2", "map_id": "Q9V3I2", "name": "Rab5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014010", "map_id": "FBgn0014010", "name": "Rab5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W329", "map_id": "Q9W329", "name": "Gga", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030141", "map_id": "FBgn0030141", "name": "Gga", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0H9", "map_id": "Q9W0H9", "name": "Rabex-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262937", "map_id": "FBgn0262937", "name": "Rabex-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488957", "map_id": "none", "name": "TBC1D3:GGA:RAB5:GTP:RABGEF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "A1Z9K4", "map_id": "A1Z9K4", "name": "RN-tre", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479983", "map_id": "none", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10436354", "map_id": "Q9VX36", "name": "ND-24", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0030853", "map_id": "FBgn0030853", "name": "ND-24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477522", "map_id": "none", "name": "NUBPL:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9V9M8", "map_id": "Q9V9M8", "name": "Dmel\\CG3262", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032986", "map_id": "FBgn0032986", "name": "Dmel\\CG3262", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436347", "map_id": "Q9VMI3", "name": "ND-51", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0031771", "map_id": "FBgn0031771", "name": "ND-51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477520", "map_id": "Q9V9M8", "name": "Dmel\\CG3262", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10436356", "map_id": "none", "name": "NDUFV2:4Fe-4S", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VX36", "map_id": "Q9VX36", "name": "ND-24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436349", "map_id": "none", "name": "NDUFV1:4Fe-4S:FMN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VMI3", "map_id": "Q9VMI3", "name": "ND-51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10485760", "map_id": "none", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10436528", "map_id": "none", "name": "NDUFA9:FAD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VPE2", "map_id": "Q9VPE2", "name": "ND-39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037001", "map_id": "FBgn0037001", "name": "ND-39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436547", "map_id": "none", "name": "NDUFS7:4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VXK7", "map_id": "Q9VXK7", "name": "ND-20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030718", "map_id": "FBgn0030718", "name": "ND-20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484249", "map_id": "none", "name": "NDUFAF7:NDUFS2:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9V4E0", "map_id": "Q9V4E0", "name": "ND-49", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039909", "map_id": "FBgn0039909", "name": "ND-49", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGR2", "map_id": "Q9VGR2", "name": "NDUFAF7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037880", "map_id": "FBgn0037880", "name": "NDUFAF7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436554", "map_id": "none", "name": "NDUFS8:2x4Fe-4S", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VF27", "map_id": "Q9VF27", "name": "ND-23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017567", "map_id": "FBgn0017567", "name": "ND-23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436540", "map_id": "Q9VZU4", "name": "ND-30", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0266582", "map_id": "FBgn0266582", "name": "ND-30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484251", "map_id": "none", "name": "IP subcomplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VZU4", "map_id": "Q9VZU4", "name": "ND-30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10484318", "map_id": "none", "name": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10484277", "map_id": "Q7K1S1", "name": "Dmel\\CG8067", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0033891", "map_id": "FBgn0033891", "name": "Dmel\\CG8067", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436408", "map_id": "P18929", "name": "mt:ND1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0013679", "map_id": "FBgn0013679", "name": "mt:ND1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484282", "map_id": "Q9VYS5", "name": "sicily", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0030352", "map_id": "FBgn0030352", "name": "sicily", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484270", "map_id": "none", "name": "Intermediate 2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P81928", "map_id": "P81928", "name": "140up", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010340", "map_id": "FBgn0010340", "name": "140up", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH39", "map_id": "Q9VH39", "name": "NDUFAF4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037777", "map_id": "FBgn0037777", "name": "NDUFAF4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1H9", "map_id": "Q9W1H9", "name": "Dmel\\CG5569", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034919", "map_id": "FBgn0034919", "name": "Dmel\\CG5569", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYC4", "map_id": "A8DYC4", "name": "ND-MWFE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085468", "map_id": "FBgn0085468", "name": "ND-MWFE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7PL91", "map_id": "Q7PL91", "name": "ND-AGGG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0058002", "map_id": "FBgn0058002", "name": "ND-AGGG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P91929", "map_id": "P91929", "name": "ND-42", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019957", "map_id": "FBgn0019957", "name": "ND-42", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJZ4", "map_id": "Q9VJZ4", "name": "ND-B22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032511", "map_id": "FBgn0032511", "name": "ND-B22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94519", "map_id": "Q94519", "name": "phospho-ND-ACP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011361", "map_id": "FBgn0011361", "name": "phospho-ND-ACP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3X7", "map_id": "Q9W3X7", "name": "ND-ASHI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029888", "map_id": "FBgn0029888", "name": "ND-ASHI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3L7", "map_id": "Q9V3L7", "name": "NP15.6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027785", "map_id": "FBgn0027785", "name": "NP15.6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W125", "map_id": "Q9W125", "name": "ND-19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035046", "map_id": "FBgn0035046", "name": "ND-19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXZ0", "map_id": "Q9VXZ0", "name": "ND-B18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030605", "map_id": "FBgn0030605", "name": "ND-B18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JYH3", "map_id": "Q7JYH3", "name": "ND-B14.7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034576", "map_id": "FBgn0034576", "name": "ND-B14.7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O97418", "map_id": "O97418", "name": "ND-B14.5A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025839", "map_id": "FBgn0025839", "name": "ND-B14.5A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTU2", "map_id": "Q9VTU2", "name": "ND-SGDH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011455", "map_id": "FBgn0011455", "name": "ND-SGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W402", "map_id": "Q9W402", "name": "ND-B16.6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029868", "map_id": "FBgn0029868", "name": "ND-B16.6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JZK1", "map_id": "Q7JZK1", "name": "ND-B14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033570", "map_id": "FBgn0033570", "name": "ND-B14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6IDF5", "map_id": "Q6IDF5", "name": "ND-B15", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033961", "map_id": "FBgn0033961", "name": "ND-B15", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQM2", "map_id": "Q9VQM2", "name": "ND-B14.5B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031505", "map_id": "FBgn0031505", "name": "ND-B14.5B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTB4", "map_id": "Q9VTB4", "name": "ND-13B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0047038", "map_id": "FBgn0047038", "name": "ND-13B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR00", "map_id": "Q9VR00", "name": "ND-B8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040705", "map_id": "FBgn0040705", "name": "ND-B8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2E8", "map_id": "Q9W2E8", "name": "ND-B12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034645", "map_id": "FBgn0034645", "name": "ND-B12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3N7", "map_id": "Q9W3N7", "name": "ND-MNLL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029971", "map_id": "FBgn0029971", "name": "ND-MNLL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQR2", "map_id": "Q9VQR2", "name": "ND-PDSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0021967", "map_id": "FBgn0021967", "name": "ND-PDSW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484284", "map_id": "none", "name": "315kDa subcomplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VYS5", "map_id": "Q9VYS5", "name": "sicily", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18929", "map_id": "P18929", "name": "mt:ND1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K1S1", "map_id": "Q7K1S1", "name": "Dmel\\CG8067", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479981", "map_id": "none", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10479977", "map_id": "none", "name": "NDUF subunits", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q94511", "map_id": "Q94511", "name": "ND-75", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017566", "map_id": "FBgn0017566", "name": "ND-75", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479979", "map_id": "none", "name": "NDUF:4Fe-4S subunits", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10484328", "map_id": "none", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10484256", "map_id": "Q9W1H9", "name": "Dmel\\CG5569", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10484261", "map_id": "Q9VH39", "name": "NDUFAF4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10484266", "map_id": "P81928", "name": "140up", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10484268", "map_id": "none", "name": "Intermediate 1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10484326", "map_id": "none", "name": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10484305", "map_id": "none", "name": "370 kDa subcomplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VLM7", "map_id": "Q9VLM7", "name": "Dmel\\CG13392", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032033", "map_id": "FBgn0032033", "name": "Dmel\\CG13392", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAI1", "map_id": "Q9VAI1", "name": "CIA30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039689", "map_id": "FBgn0039689", "name": "CIA30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U6M0", "map_id": "Q9U6M0", "name": "ECSIT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028436", "map_id": "FBgn0028436", "name": "ECSIT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18933", "map_id": "P18933", "name": "mt:ND6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013685", "map_id": "FBgn0013685", "name": "mt:ND6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P03896", "map_id": "P03896", "name": "mt:ND2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013680", "map_id": "FBgn0013680", "name": "mt:ND2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2M9", "map_id": "Q9W2M9", "name": "Dmel\\CG15653", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034578", "map_id": "FBgn0034578", "name": "Dmel\\CG15653", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q059A4", "map_id": "Q059A4", "name": "Dmel\\CG4627", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033808", "map_id": "FBgn0033808", "name": "Dmel\\CG4627", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18930", "map_id": "P18930", "name": "mt:ND3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013681", "map_id": "FBgn0013681", "name": "mt:ND3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484307", "map_id": "none", "name": "550kDa complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10477524", "map_id": "none", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_169274", "map_id": "none", "name": "4Fe-4S", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10484324", "map_id": "none", "name": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10436370", "map_id": "P18932", "name": "mt:ND5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0013684", "map_id": "FBgn0013684", "name": "mt:ND5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436365", "map_id": "P18931", "name": "mt:ND4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0262952", "map_id": "FBgn0262952", "name": "mt:ND4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484309", "map_id": "none", "name": "815kDa complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P18931", "map_id": "P18931", "name": "mt:ND4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18932", "map_id": "P18932", "name": "mt:ND5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10484322", "map_id": "none", "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10484320", "map_id": "none", "name": "980kDa complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VMU0", "map_id": "Q9VMU0", "name": "ND-13A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031684", "map_id": "FBgn0031684", "name": "ND-13A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWI0", "map_id": "Q9VWI0", "name": "ND-18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031021", "map_id": "FBgn0031021", "name": "ND-18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9NEW0", "map_id": "M9NEW0", "name": "Dmel\\CG43346", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263051", "map_id": "FBgn0263051", "name": "Dmel\\CG43346", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQD7", "map_id": "Q9VQD7", "name": "ND-B17.2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031436", "map_id": "FBgn0031436", "name": "ND-B17.2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436566", "map_id": "none", "name": "Complex I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10484247", "map_id": "Q9VGR2", "name": "NDUFAF7", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10484314", "map_id": "M9NEW0", "name": "Dmel\\CG43346", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10484303", "map_id": "none", "name": "MCIA complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10484272", "map_id": "none", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10436521", "map_id": "none", "name": "HP subcomplex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10492180", "map_id": "none", "name": "AHRR binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10492174", "map_id": "E1JIM6", "name": "ss", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0003513", "map_id": "FBgn0003513", "name": "ss", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458122", "map_id": "O15945", "name": "tgo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0264075", "map_id": "FBgn0264075", "name": "tgo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10492178", "map_id": "none", "name": "AHRR:ARNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O15945", "map_id": "O15945", "name": "tgo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JIM6", "map_id": "E1JIM6", "name": "ss", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10492214", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10492170", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8936852", "map_id": "CHEBI:28119", "name": "TCDD", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10492212", "map_id": "none", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492172", "map_id": "none", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10492168", "map_id": "none", "name": "AHR:2xHSP90AB1:AIP:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10492220", "map_id": "none", "name": "AHR:TCDD binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492216", "map_id": "none", "name": "AHR:TCDD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10492218", "map_id": "none", "name": "AHR:TCDD:ARNT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10426932", "map_id": "none", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10426946", "map_id": "none", "name": "CDC6 association with ORC:origin complexes mediated by MCM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426942", "map_id": "none", "name": "ORC:origin of replication", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10436878", "map_id": "none", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10436872", "map_id": "none", "name": "ATPase:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q24439", "map_id": "Q24439", "name": "ATPsynO", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016691", "map_id": "FBgn0016691", "name": "ATPsynO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2X6", "map_id": "Q9W2X6", "name": "ATPsyndelta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028342", "map_id": "FBgn0028342", "name": "ATPsyndelta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O01666", "map_id": "O01666", "name": "ATPsyngamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020235", "map_id": "FBgn0020235", "name": "ATPsyngamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q05825", "map_id": "Q05825", "name": "ATPsynbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010217", "map_id": "FBgn0010217", "name": "ATPsynbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXN2", "map_id": "Q9VXN2", "name": "sun", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014391", "map_id": "FBgn0014391", "name": "sun", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P35381", "map_id": "P35381", "name": "blw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011211", "map_id": "FBgn0011211", "name": "blw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKM3", "map_id": "Q9VKM3", "name": "ATPsynG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010612", "map_id": "FBgn0010612", "name": "ATPsynG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P00850", "map_id": "P00850", "name": "mt:ATPase6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013672", "map_id": "FBgn0013672", "name": "mt:ATPase6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6NN09", "map_id": "Q6NN09", "name": "ATPsynC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039830", "map_id": "FBgn0039830", "name": "ATPsynC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W141", "map_id": "Q9W141", "name": "ATPsynF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035032", "map_id": "FBgn0035032", "name": "ATPsynF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24407", "map_id": "Q24407", "name": "ATPsynCF6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016119", "map_id": "FBgn0016119", "name": "ATPsynCF6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O77134", "map_id": "O77134", "name": "ATPsynE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038224", "map_id": "FBgn0038224", "name": "ATPsynE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24251", "map_id": "Q24251", "name": "ATPsynD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016120", "map_id": "FBgn0016120", "name": "ATPsynD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94516", "map_id": "Q94516", "name": "ATPsynB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019644", "map_id": "FBgn0019644", "name": "ATPsynB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAA9", "map_id": "A1ZAA9", "name": "ATPW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034081", "map_id": "FBgn0034081", "name": "ATPW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436868", "map_id": "none", "name": "F1Fo ATP synthase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10436875", "map_id": "none", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10436870", "map_id": "none", "name": "ATPase:ADP:Pi", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10436880", "map_id": "none", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10442136", "map_id": "none", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442132", "map_id": "Q9VWV8", "name": "NOSIP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030915", "map_id": "FBgn0030915", "name": "NOSIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10441803", "map_id": "none", "name": "palmitoylated, myristoylated eNOS dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10442134", "map_id": "none", "name": "eNOS:NOSIP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VWV8", "map_id": "Q9VWV8", "name": "NOSIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10442216", "map_id": "none", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442214", "map_id": "none", "name": "eNOS:NOSIP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10442198", "map_id": "none", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_184174", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442196", "map_id": "Q27571", "name": "Nos", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441862", "map_id": "Q27571", "name": "Nos", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10442194", "map_id": "none", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10442144", "map_id": "Q27571", "name": "Nos", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10442191", "map_id": "none", "name": "Homologues of ZDHHC21", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10441870", "map_id": "none", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10441864", "map_id": "none", "name": "myristoylated eNOS dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10441868", "map_id": "none", "name": "myristoylated eNOS dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10442218", "map_id": "none", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10459882", "map_id": "none", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10478081", "map_id": "none", "name": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5693410", "map_id": "CHEBI:17170", "name": "DMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10478076", "map_id": "Q9VYF0", "name": "Dmel\\CG1764", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030467", "map_id": "FBgn0030467", "name": "Dmel\\CG1764", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10442208", "map_id": "none", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10442205", "map_id": "none", "name": "LYPLA1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10434767", "map_id": "none", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434721", "map_id": "none", "name": "Elongin Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VCP0", "map_id": "Q9VCP0", "name": "EloA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039066", "map_id": "FBgn0039066", "name": "EloA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434758", "map_id": "A8JV07", "name": "Dmel\\CG9915", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0030738", "map_id": "FBgn0030738", "name": "Dmel\\CG9915", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434681", "map_id": "none", "name": "Early elongation complex with hyperphosphorylated Pol II CTD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7JRJ1", "map_id": "Q7JRJ1", "name": "Eaf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033166", "map_id": "FBgn0033166", "name": "Eaf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQI9", "map_id": "Q9VQI9", "name": "lilli", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041111", "map_id": "FBgn0041111", "name": "lilli", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW51", "map_id": "Q9VW51", "name": "Ell", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434698", "map_id": "none", "name": "FACT complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8IRG6", "map_id": "Q8IRG6", "name": "dre4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002183", "map_id": "FBgn0002183", "name": "dre4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q05344", "map_id": "Q05344", "name": "Ssrp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010278", "map_id": "FBgn0010278", "name": "Ssrp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434763", "map_id": "Q9W420", "name": "Spt6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0028982", "map_id": "FBgn0028982", "name": "Spt6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10434686", "map_id": "P20232", "name": "TfIIS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10434765", "map_id": "none", "name": "Elongation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W420", "map_id": "Q9W420", "name": "Spt6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JV07", "map_id": "A8JV07", "name": "Dmel\\CG9915", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475420", "map_id": "none", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661268", "map_id": "CHEBI:13115", "name": "L-gulonate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5661262", "map_id": "CHEBI:57655", "name": "3-dehydro-L-gulonate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475417", "map_id": "none", "name": "CRYL1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VXI1", "map_id": "Q9VXI1", "name": "Had1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286508", "map_id": "FBgn0286508", "name": "Had1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475402", "map_id": "none", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5660036", "map_id": "CHEBI:17399", "name": "L-xylulose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5660033", "map_id": "CHEBI:17151", "name": "xylitol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475399", "map_id": "none", "name": "DCXR tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VWP2", "map_id": "Q9VWP2", "name": "Dmel\\CG7322", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030968", "map_id": "FBgn0030968", "name": "Dmel\\CG7322", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475431", "map_id": "none", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661281", "map_id": "CHEBI:17140", "name": "D-xylulose", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10474621", "map_id": "none", "name": "SORD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O96299", "map_id": "O96299", "name": "Sodh-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022359", "map_id": "FBgn0022359", "name": "Sodh-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475428", "map_id": "none", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475425", "map_id": "Q9VEQ0", "name": "Dmel\\CG3534", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0038463", "map_id": "FBgn0038463", "name": "Dmel\\CG3534", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475410", "map_id": "none", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5661264", "map_id": "CHEBI:15748", "name": "D-glucuronate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475407", "map_id": "Q9VZK8", "name": "Dmel\\CG12766", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035476", "map_id": "FBgn0035476", "name": "Dmel\\CG12766", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454299", "map_id": "none", "name": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_880041", "map_id": "CHEBI:16724", "name": "HBUT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_880046", "map_id": "CHEBI:57706", "name": "SUCCSA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_879997", "map_id": "CHEBI:32796", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10454286", "map_id": "Q9W265", "name": "T3dh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0017482", "map_id": "FBgn0017482", "name": "T3dh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454297", "map_id": "none", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10454294", "map_id": "Q7K511", "name": "D2hgdh", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0023507", "map_id": "FBgn0023507", "name": "D2hgdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_880069", "map_id": "CHEBI:27638", "name": "Co2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_880067", "map_id": "CHEBI:29105", "name": "Zn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113527", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10454307", "map_id": "none", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_880013", "map_id": "CHEBI:32797", "name": "2HG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10454304", "map_id": "Q9VJ28", "name": "L2HGDH", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0032729", "map_id": "FBgn0032729", "name": "L2HGDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479469", "map_id": "none", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694130", "map_id": "CHEBI:15694", "name": "(R)-S-LGSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479466", "map_id": "none", "name": "HAGH-2:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IPU3", "map_id": "Q8IPU3", "name": "tzn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037024", "map_id": "FBgn0037024", "name": "tzn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496099", "map_id": "none", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10442340", "map_id": "P91622", "name": "Pdk", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_9010792", "map_id": "none", "name": "DCA", "type": "inhibitor", "sub_type": "other", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10442392", "map_id": "none", "name": "PDP dephosphorylates p-lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10442389", "map_id": "none", "name": "PDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9W4K8", "map_id": "Q9W4K8", "name": "Dmel\\CG3626", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029706", "map_id": "FBgn0029706", "name": "Dmel\\CG3626", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3Q1", "map_id": "Q9W3Q1", "name": "Pdp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029958", "map_id": "FBgn0029958", "name": "Pdp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496106", "map_id": "none", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_904849", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_3301973", "map_id": "CHEBI:17883", "name": "HCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10496103", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VHD2", "map_id": "Q9VHD2", "name": "GstZ2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037697", "map_id": "FBgn0037697", "name": "GstZ2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_1655887", "map_id": "CHEBI:16856", "name": "GSH", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10496180", "map_id": "none", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10496177", "map_id": "none", "name": "ME1:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86NT5", "map_id": "Q86NT5", "name": "Menl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029154", "map_id": "FBgn0029154", "name": "Menl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAF6", "map_id": "A1ZAF6", "name": "Menl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029153", "map_id": "FBgn0029153", "name": "Menl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG31", "map_id": "Q9VG31", "name": "Men", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002719", "map_id": "FBgn0002719", "name": "Men", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JIZ4", "map_id": "E1JIZ4", "name": "Men-b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029155", "map_id": "FBgn0029155", "name": "Men-b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K3R0", "map_id": "Q7K3R0", "name": "Dmel\\CG7848", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034127", "map_id": "FBgn0034127", "name": "Dmel\\CG7848", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486326", "map_id": "none", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6807616", "map_id": "CHEBI:422", "name": "LACT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10486323", "map_id": "none", "name": "Homologues of LDHAL6B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q95028", "map_id": "Q95028", "name": "Ldh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001258", "map_id": "FBgn0001258", "name": "Ldh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z9F8", "map_id": "A1Z9F8", "name": "NEST:bs27e02", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033856", "map_id": "FBgn0033856", "name": "NEST:bs27e02", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428151", "map_id": "none", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428148", "map_id": "none", "name": "LDH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10496232", "map_id": "none", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9012375", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10470842", "map_id": "none", "name": "Homologues of VDAC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9VKP4", "map_id": "Q9VKP4", "name": "CG31722-B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260453", "map_id": "FBgn0260453", "name": "CG31722-B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKP3", "map_id": "Q9VKP3", "name": "CG31722", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260454", "map_id": "FBgn0260454", "name": "CG31722", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKP2", "map_id": "Q9VKP2", "name": "Porin2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0069354", "map_id": "FBgn0069354", "name": "Porin2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94920", "map_id": "Q94920", "name": "porin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004363", "map_id": "FBgn0004363", "name": "porin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428868", "map_id": "none", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10429155", "map_id": "none", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10478225", "map_id": "none", "name": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694074", "map_id": "CHEBI:17158", "name": "MGXL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10478222", "map_id": "none", "name": "GLO1 dimer:2xZn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1Z6X6", "map_id": "A1Z6X6", "name": "Glo1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283450", "map_id": "FBgn0283450", "name": "Glo1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496229", "map_id": "none", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10496226", "map_id": "none", "name": "ME3:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10428534", "map_id": "none", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428531", "map_id": "none", "name": "CS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9W401", "map_id": "Q9W401", "name": "kdn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261955", "map_id": "FBgn0261955", "name": "kdn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428598", "map_id": "none", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70958", "map_id": "CHEBI:57292", "name": "SUCC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113536", "map_id": "CHEBI:30031", "name": "SUCCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428595", "map_id": "none", "name": "SUCLA2:SUCLG1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q94522", "map_id": "Q94522", "name": "Scsalpha1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004888", "map_id": "FBgn0004888", "name": "Scsalpha1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95U38", "map_id": "Q95U38", "name": "ScsbetaA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037643", "map_id": "FBgn0037643", "name": "ScsbetaA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10496201", "map_id": "none", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10496198", "map_id": "none", "name": "ME2:Mg2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_113588", "map_id": "CHEBI:18012", "name": "FUMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10496144", "map_id": "none", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10496141", "map_id": "none", "name": "FAHD1:Mg2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VDE2", "map_id": "Q9VDE2", "name": "Dmel\\CG5793", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038858", "map_id": "FBgn0038858", "name": "Dmel\\CG5793", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428524", "map_id": "none", "name": "citrate <=> isocitrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29938", "map_id": "CHEBI:151", "name": "ISCIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428521", "map_id": "Q9VIE8", "name": "mAcon1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0010100", "map_id": "FBgn0010100", "name": "mAcon1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10451212", "map_id": "none", "name": "(S)-Malate <=> Fumarate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428551", "map_id": "none", "name": "FH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9W3X6", "map_id": "Q9W3X6", "name": "Fum1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286222", "map_id": "FBgn0286222", "name": "Fum1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428583", "map_id": "none", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428580", "map_id": "none", "name": "SDH complex (ox.)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VGS3", "map_id": "Q9VGS3", "name": "SdhC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037873", "map_id": "FBgn0037873", "name": "SdhC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P21914", "map_id": "P21914", "name": "SdhB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014028", "map_id": "FBgn0014028", "name": "SdhB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCI5", "map_id": "Q9VCI5", "name": "SdhD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039112", "map_id": "FBgn0039112", "name": "SdhD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94523", "map_id": "Q94523", "name": "SdhA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261439", "map_id": "FBgn0261439", "name": "SdhA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428870", "map_id": "none", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428624", "map_id": "none", "name": "lipo-aKGDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:17460", "map_id": "CHEBI:17460", "name": "CHEBI:17460", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGQ1", "map_id": "Q9VGQ1", "name": "alpha-KGDHC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037891", "map_id": "FBgn0037891", "name": "alpha-KGDHC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JNU6", "map_id": "A8JNU6", "name": "Nc73EF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010352", "map_id": "FBgn0010352", "name": "Nc73EF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95T35", "map_id": "Q95T35", "name": "CG18170", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035240", "map_id": "FBgn0035240", "name": "CG18170", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428516", "map_id": "none", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428513", "map_id": "none", "name": "IDH3 complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q8MT18", "map_id": "Q8MT18", "name": "Dmel\\CG5028", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039358", "map_id": "FBgn0039358", "name": "Dmel\\CG5028", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VD58", "map_id": "Q9VD58", "name": "Idh3b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038922", "map_id": "FBgn0038922", "name": "Idh3b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWH4", "map_id": "Q9VWH4", "name": "Idh3a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027291", "map_id": "FBgn0027291", "name": "Idh3a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10429124", "map_id": "none", "name": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428541", "map_id": "none", "name": "MDH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VEB1", "map_id": "Q9VEB1", "name": "Mdh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262559", "map_id": "FBgn0262559", "name": "Mdh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10429122", "map_id": "none", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113525", "map_id": "CHEBI:17552", "name": "GDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10429119", "map_id": "none", "name": "SUCLG1:SUCLG2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9V470", "map_id": "Q9V470", "name": "ScsbetaG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029118", "map_id": "FBgn0029118", "name": "ScsbetaG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487120", "map_id": "none", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10487116", "map_id": "none", "name": "other COG interacting snares", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q7JY00", "map_id": "Q7JY00", "name": "Syx6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037084", "map_id": "FBgn0037084", "name": "Syx6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0N6", "map_id": "Q9W0N6", "name": "Vti1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260862", "map_id": "FBgn0260862", "name": "Vti1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1I8", "map_id": "Q9W1I8", "name": "Snap29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034913", "map_id": "FBgn0034913", "name": "Snap29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHB5", "map_id": "Q9VHB5", "name": "Vps45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261049", "map_id": "FBgn0261049", "name": "Vps45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR90", "map_id": "Q9VR90", "name": "Syx16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031106", "map_id": "FBgn0031106", "name": "Syx16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VE50", "map_id": "Q9VE50", "name": "Gos28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0044871", "map_id": "FBgn0044871", "name": "Gos28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486635", "map_id": "none", "name": "COG complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q961G1", "map_id": "Q961G1", "name": "Cog3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031536", "map_id": "FBgn0031536", "name": "Cog3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAD6", "map_id": "Q9VAD6", "name": "Cog7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051040", "map_id": "FBgn0051040", "name": "Cog7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95TN4", "map_id": "Q95TN4", "name": "Cog4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032258", "map_id": "FBgn0032258", "name": "Cog4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGC3", "map_id": "Q9VGC3", "name": "Cog1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037998", "map_id": "FBgn0037998", "name": "Cog1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKH0", "map_id": "Q9VKH0", "name": "Cog8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032361", "map_id": "FBgn0032361", "name": "Cog8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJD3", "map_id": "Q9VJD3", "name": "fws", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024689", "map_id": "FBgn0024689", "name": "fws", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VF78", "map_id": "Q9VF78", "name": "Cog2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026634", "map_id": "FBgn0026634", "name": "Cog2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V564", "map_id": "Q9V564", "name": "Cog6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033401", "map_id": "FBgn0033401", "name": "Cog6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487118", "map_id": "none", "name": "COG complex:Golgi snares", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10487796", "map_id": "none", "name": "ARF1:GTP binds Golgin TRIP11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10487792", "map_id": "none", "name": "TRIP11:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "species_10487794", "map_id": "none", "name": "ARF1:GTP:TRIP11:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10488246", "map_id": "none", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10488242", "map_id": "none", "name": "other COG-interacting RABs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9W0A7", "map_id": "Q9W0A7", "name": "RabX5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035255", "map_id": "FBgn0035255", "name": "RabX5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3Q0", "map_id": "Q9W3Q0", "name": "Rab39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029959", "map_id": "FBgn0029959", "name": "Rab39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM50", "map_id": "Q9VM50", "name": "Rab30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031882", "map_id": "FBgn0031882", "name": "Rab30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488244", "map_id": "none", "name": "COG complex:RABs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10487719", "map_id": "none", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10487715", "map_id": "none", "name": "STX:PalmC-YKT6:BET1L:GOSR1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9W3M8", "map_id": "Q9W3M8", "name": "Ykt6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260858", "map_id": "FBgn0260858", "name": "Ykt6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487717", "map_id": "none", "name": "STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10487815", "map_id": "none", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10487801", "map_id": "Q0E8N2", "name": "step", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0086779", "map_id": "FBgn0086779", "name": "step", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487813", "map_id": "none", "name": "ARF1:GTP:CYTH1,2,3,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q0E8N2", "map_id": "Q0E8N2", "name": "step", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487822", "map_id": "none", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10487819", "map_id": "none", "name": "ARF1:GDP:CYTH1,2,3,4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10474701", "map_id": "none", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10474698", "map_id": "none", "name": "SLC2A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10474773", "map_id": "none", "name": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_5653871", "map_id": "CHEBI:17716", "name": "Lac", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10474770", "map_id": "none", "name": "B4GALT1:LALBA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "P83972", "map_id": "P83972", "name": "LysD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004427", "map_id": "FBgn0004427", "name": "LysD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZBX6", "map_id": "A1ZBX6", "name": "Dmel\\CG16799", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034538", "map_id": "FBgn0034538", "name": "Dmel\\CG16799", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P83971", "map_id": "P83971", "name": "LALBA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004426", "map_id": "FBgn0004426", "name": "LALBA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAB8", "map_id": "A1ZAB8", "name": "Dmel\\CG7798", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034092", "map_id": "FBgn0034092", "name": "Dmel\\CG7798", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P37161", "map_id": "P37161", "name": "LysX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004431", "map_id": "FBgn0004431", "name": "LysX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z9D5", "map_id": "A1Z9D5", "name": "Dmel\\CG30062", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050062", "map_id": "FBgn0050062", "name": "Dmel\\CG30062", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P37160", "map_id": "P37160", "name": "LysS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004430", "map_id": "FBgn0004430", "name": "LysS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4C2", "map_id": "Q9W4C2", "name": "Dmel\\CG16756", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029765", "map_id": "FBgn0029765", "name": "Dmel\\CG16756", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P37159", "map_id": "P37159", "name": "LysE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004428", "map_id": "FBgn0004428", "name": "LysE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSA5", "map_id": "Q9VSA5", "name": "Dmel\\CG8492", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035813", "map_id": "FBgn0035813", "name": "Dmel\\CG8492", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P29615", "map_id": "P29615", "name": "LysP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004429", "map_id": "FBgn0004429", "name": "LysP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q08694", "map_id": "Q08694", "name": "LysB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004425", "map_id": "FBgn0004425", "name": "LysB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZBX7", "map_id": "A1ZBX7", "name": "Dmel\\CG11159", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034539", "map_id": "FBgn0034539", "name": "Dmel\\CG11159", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10474803", "map_id": "none", "name": "B4GALT1 binds LALBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10474801", "map_id": "none", "name": "Homologues of LALBA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10455850", "map_id": "Q7KN92", "name": "beta4GalNAcTA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_5653875", "map_id": "CHEBI:29035", "name": "Mn2+", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10431982", "map_id": "none", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10427788", "map_id": "none", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427778", "map_id": "none", "name": "Homologues of p-S123-CDC25A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438571", "map_id": "none", "name": "Binding of ATR-ATRIP to the RPA-ssDNA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438544", "map_id": "none", "name": "RPA complexed to ssDNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10438569", "map_id": "none", "name": "ATR:ATRIP:RPA:ssDNA signaling complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438567", "map_id": "none", "name": "Stalling of DNA replication fork and RPA binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_176104", "map_id": "none", "name": "Persistent single-stranded DNA", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10438548", "map_id": "none", "name": "Recruitment of Rad17-RFC complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438542", "map_id": "none", "name": "RAD17:RFC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O96532", "map_id": "O96532", "name": "Rad17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025808", "map_id": "FBgn0025808", "name": "Rad17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438546", "map_id": "none", "name": "Rad17-RFC complex bound to DNA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438612", "map_id": "none", "name": "Loading of claspin onto DNA during replication origin firing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438602", "map_id": "none", "name": "Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8IRB5", "map_id": "Q8IRB5", "name": "Claspin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438595", "map_id": "none", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438590", "map_id": "none", "name": "RAD9:HUS1:RAD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VQD4", "map_id": "Q9VQD4", "name": "Rad1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026778", "map_id": "FBgn0026778", "name": "Rad1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VN60", "map_id": "Q9VN60", "name": "Hus1-like", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026417", "map_id": "FBgn0026417", "name": "Hus1-like", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JNV5", "map_id": "A8JNV5", "name": "Rad9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025807", "map_id": "FBgn0025807", "name": "Rad9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438592", "map_id": "none", "name": "Rad9-Hus1-Rad1 bound to DNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438610", "map_id": "none", "name": "Activation of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438608", "map_id": "none", "name": "Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_209322", "map_id": "none", "name": "In the absence of ARM, GRO binds to PAN and inhibits transcription", "reversible": "false", "notes": "In the absence of Armadillo (ARM) due to an active 'destruction complex' removing it in the cytoplasm, the protein Groucho (GRO) binds to Pangolin (PAN) and inhibits transcription.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_205750", "map_id": "P16371", "name": "GRO", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_205730", "map_id": "P91943", "name": "PAN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_206798", "map_id": "none", "name": "GRO:PAN", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P91943", "map_id": "P91943", "name": "PAN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PAN", "map_id": "PAN", "name": "PAN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464863", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065269", "map_id": "CHEBI:63516", "name": "ChEBI:63516 chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2105025", "map_id": "CHEBI:63873", "name": "IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10462796", "map_id": "none", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10462724", "map_id": "none", "name": "DSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VJ82", "map_id": "Q9VJ82", "name": "kon", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032683", "map_id": "FBgn0032683", "name": "kon", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10462750", "map_id": "none", "name": "CSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10462776", "map_id": "none", "name": "CSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10462794", "map_id": "none", "name": "DSPGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10461387", "map_id": "none", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2104993", "map_id": "CHEBI:63868", "name": "CHEBI:63868 chain", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10497909", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10461385", "map_id": "none", "name": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2065213", "map_id": "CHEBI:63517", "name": "ChEBI:63517 chain", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10458176", "map_id": "none", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1236719", "map_id": "CHEBI:16670", "name": "Exogenous soluble antigen", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10497911", "map_id": "none", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2162223", "map_id": "none", "name": "GlcNAc-GlcA-GlcNAc", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2162224", "map_id": "CHEBI:64024", "name": "GlcA-\u03b21,3-GlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10465157", "map_id": "none", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2160866", "map_id": "none", "name": "(HA)2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10465155", "map_id": "none", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10465153", "map_id": "none", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10438422", "map_id": "none", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174370", "map_id": "CHEBI:17709", "name": "APS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438414", "map_id": "Q8IQV1", "name": "Papss", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0020389", "map_id": "FBgn0020389", "name": "Papss", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438419", "map_id": "none", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10461983", "map_id": "none", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10461911", "map_id": "none", "name": "Gal-Gal-Xyl-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10461945", "map_id": "none", "name": "GlcA-Gal-Gal-Xyl-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10461980", "map_id": "none", "name": "B3GAT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O97422", "map_id": "O97422", "name": "GlcAT-I", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0066114", "map_id": "FBgn0066114", "name": "GlcAT-I", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTG7", "map_id": "Q9VTG7", "name": "GlcAT-P", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036144", "map_id": "FBgn0036144", "name": "GlcAT-P", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLA1", "map_id": "Q9VLA1", "name": "GlcAT-S", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032135", "map_id": "FBgn0032135", "name": "GlcAT-S", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497906", "map_id": "none", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10461978", "map_id": "none", "name": "B3GAT3:Mn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10462025", "map_id": "none", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10462017", "map_id": "none", "name": "Gal-Xyl-proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462022", "map_id": "A1Z7G9", "name": "beta3GalTII", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0033315", "map_id": "FBgn0033315", "name": "beta3GalTII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461877", "map_id": "none", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10461833", "map_id": "none", "name": "GAG core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10461867", "map_id": "none", "name": "xylosyl-core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10461872", "map_id": "Q7KVA1", "name": "oxt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0015360", "map_id": "FBgn0015360", "name": "oxt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10462033", "map_id": "none", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10462030", "map_id": "Q9VBZ9", "name": "beta4GalT7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0039258", "map_id": "FBgn0039258", "name": "beta4GalT7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10462812", "map_id": "none", "name": "Dermatan sulfate can be further sulfated on position 2 of iduronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10462684", "map_id": "none", "name": "D4S-PGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462804", "map_id": "none", "name": "D2,4(S)2-PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462809", "map_id": "Q86BJ3", "name": "pip", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0003089", "map_id": "FBgn0003089", "name": "pip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10462828", "map_id": "none", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10462826", "map_id": "none", "name": "DSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10462415", "map_id": "none", "name": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10462365", "map_id": "none", "name": "chondroitin(3)-core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462375", "map_id": "none", "name": "C4S-PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462412", "map_id": "none", "name": "CHST9,11,12,13", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10463695", "map_id": "none", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_10463693", "map_id": "none", "name": "CSPGs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10462445", "map_id": "none", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10462345", "map_id": "none", "name": "chondroitin(1)-core proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462425", "map_id": "none", "name": "chondroitin(2)-core proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462437", "map_id": "none", "name": "CHPF,CHSY3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VYH2", "map_id": "Q9VYH2", "name": "Chpf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263005", "map_id": "FBgn0263005", "name": "Chpf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KUZ9", "map_id": "Q7KUZ9", "name": "Chsy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030662", "map_id": "FBgn0030662", "name": "Chsy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10462440", "map_id": "none", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10462355", "map_id": "none", "name": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10462335", "map_id": "none", "name": "GlcA-Gal-Gal-Xyl-CS proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462350", "map_id": "A1Z863", "name": "Csgalnact", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0033500", "map_id": "FBgn0033500", "name": "Csgalnact", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497804", "map_id": "none", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10497801", "map_id": "Q7KUZ9", "name": "Chsy", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10497807", "map_id": "none", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10462672", "map_id": "none", "name": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10462649", "map_id": "none", "name": "C6S-PG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10462669", "map_id": "none", "name": "CHST3,7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10461519", "map_id": "none", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_870330", "map_id": "CHEBI:18297", "name": "I1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10461516", "map_id": "none", "name": "IMPA1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VUW3", "map_id": "Q9VUW3", "name": "IMP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036553", "map_id": "FBgn0036553", "name": "IMP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTW5", "map_id": "Q7KTW5", "name": "Dmel\\CG9391", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037063", "map_id": "FBgn0037063", "name": "Dmel\\CG9391", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUW2", "map_id": "Q9VUW2", "name": "IMP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUW1", "map_id": "Q9VUW1", "name": "cg17026", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036550", "map_id": "FBgn0036550", "name": "cg17026", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUW4", "map_id": "Q9VUW4", "name": "IMP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VP62", "map_id": "Q9VP62", "name": "Dmel\\CG9389", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037064", "map_id": "FBgn0037064", "name": "Dmel\\CG9389", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461647", "map_id": "none", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629746", "map_id": "CHEBI:28858", "name": "I(3,4)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1629731", "map_id": "CHEBI:18169", "name": "I3P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10461723", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1629739", "map_id": "CHEBI:17816", "name": "I(1,4)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10461720", "map_id": "none", "name": "INPP5A/B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B7Z0Q2", "map_id": "B7Z0Q2", "name": "5PtaseI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259178", "map_id": "FBgn0259178", "name": "5PtaseI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461611", "map_id": "none", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629769", "map_id": "CHEBI:18225", "name": "I(1,3)P2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10461674", "map_id": "none", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629753", "map_id": "CHEBI:18384", "name": "I4P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10476185", "map_id": "none", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2162232", "map_id": "CHEBI:15748", "name": "GlcA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10476182", "map_id": "none", "name": "MIOX:2xFe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VTU9", "map_id": "Q9VTU9", "name": "Dmel\\CG6910", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036262", "map_id": "FBgn0036262", "name": "Dmel\\CG6910", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461671", "map_id": "none", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10461572", "map_id": "none", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10461668", "map_id": "none", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10461665", "map_id": "none", "name": "INPP1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VFP6", "map_id": "Q9VFP6", "name": "Ipp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016672", "map_id": "FBgn0016672", "name": "Ipp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461603", "map_id": "none", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629756", "map_id": "CHEBI:4170", "name": "Glc6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10461600", "map_id": "none", "name": "ISYNA1:NAD+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O97477", "map_id": "O97477", "name": "Inos", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025885", "map_id": "FBgn0025885", "name": "Inos", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461744", "map_id": "none", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10435903", "map_id": "none", "name": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10435829", "map_id": "none", "name": "Homologues of 10xCbxE-F7(21-466)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10435901", "map_id": "none", "name": "Homologues of pro-factor VII", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10435817", "map_id": "none", "name": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10435815", "map_id": "none", "name": "pro-factor X", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10435779", "map_id": "none", "name": "pro-factor X", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10436713", "map_id": "none", "name": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10436709", "map_id": "none", "name": "Homologues of 13xCbxE-PROZ(24-400)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10436663", "map_id": "none", "name": "Homologues of 13xCbxE-PROZ(24-400)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10436697", "map_id": "none", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10436693", "map_id": "Q9W0A0", "name": "drpr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "FBgn0027594", "map_id": "FBgn0027594", "name": "phospho-drpr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436695", "map_id": "Q9W0A0", "name": "drpr", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10435879", "map_id": "none", "name": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10435863", "map_id": "none", "name": "pro-protein C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10435877", "map_id": "none", "name": "pro-protein C", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10435972", "map_id": "none", "name": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13959", "compartment_display": "COPII-coated ER to Golgi transport vesicle" }, { "id": "species_10435958", "map_id": "none", "name": "Homologues of 12xCbxE-3D-F9(29-461)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10435932", "map_id": "none", "name": "Homologues of 12xCbxE-3D-F9(29-461)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10473803", "map_id": "none", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10473254", "map_id": "none", "name": "BBSome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VPP9", "map_id": "Q9VPP9", "name": "BBS8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031255", "map_id": "FBgn0031255", "name": "BBS8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8E9", "map_id": "A1Z8E9", "name": "BBS4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033578", "map_id": "FBgn0033578", "name": "BBS4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7YZM8", "map_id": "B7YZM8", "name": "BBS9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034622", "map_id": "FBgn0034622", "name": "BBS9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS19", "map_id": "Q9VS19", "name": "BBS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035741", "map_id": "FBgn0035741", "name": "BBS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JIG6", "map_id": "E1JIG6", "name": "BBIP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260237", "map_id": "FBgn0260237", "name": "BBIP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7P3", "map_id": "Q9I7P3", "name": "BBS5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037280", "map_id": "FBgn0037280", "name": "BBS5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473799", "map_id": "none", "name": "BBSome ciliary cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10473785", "map_id": "none", "name": "ARL6:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A1ZBK9", "map_id": "A1ZBK9", "name": "Arl6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034446", "map_id": "FBgn0034446", "name": "Arl6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473801", "map_id": "none", "name": "ARL6:GTP:BBSome:ciliary cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10473835", "map_id": "none", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_261122", "compartment_display": "ciliary membrane" }, { "id": "species_10473833", "map_id": "none", "name": "ARL6:GTP:BBSome:ciliary cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_261122", "compartment_display": "ciliary membrane", "complex": "true" }, { "id": "reaction_10488803", "map_id": "none", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10488798", "map_id": "none", "name": "C3a, C5a", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10488800", "map_id": "none", "name": "C3a-desArg, C5a-desArg", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10464252", "map_id": "none", "name": "Homologues of CPB2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10455979", "map_id": "none", "name": "Complement factor I complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10455955", "map_id": "none", "name": "Homologues of CFI(19-335)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "A1Z7M3", "map_id": "A1Z7M3", "name": "Np", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265011", "map_id": "FBgn0265011", "name": "Np", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DY75", "map_id": "A8DY75", "name": "Dmel\\CG8172", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033362", "map_id": "FBgn0033362", "name": "Dmel\\CG8172", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRS5", "map_id": "Q9VRS5", "name": "SP127", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035663", "map_id": "FBgn0035663", "name": "SP127", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z709", "map_id": "A1Z709", "name": "Corin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033192", "map_id": "FBgn0033192", "name": "Corin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7M7", "map_id": "A1Z7M7", "name": "SP54", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033365", "map_id": "FBgn0033365", "name": "SP54", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q05319", "map_id": "Q05319", "name": "Sb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003319", "map_id": "FBgn0003319", "name": "Sb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7M5", "map_id": "A1Z7M5", "name": "SP67", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033363", "map_id": "FBgn0033363", "name": "SP67", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7YZU2", "map_id": "B7YZU2", "name": "flz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286782", "map_id": "FBgn0286782", "name": "flz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZH5", "map_id": "Q9VZH5", "name": "SP18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035501", "map_id": "FBgn0035501", "name": "SP18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10455975", "map_id": "none", "name": "Homologues of CFI(340-583)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10455977", "map_id": "none", "name": "CFI", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10457578", "map_id": "none", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10456081", "map_id": "none", "name": "Homologues of CD46", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "B7YZX0", "map_id": "B7YZX0", "name": "Hasp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032797", "map_id": "FBgn0032797", "name": "Hasp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JUX3", "map_id": "A8JUX3", "name": "CT26106", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030617", "map_id": "FBgn0030617", "name": "CT26106", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10456085", "map_id": "none", "name": "CD46:Cell surface:C3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10467082", "map_id": "none", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10456099", "map_id": "none", "name": "deamidated-Q1013-C4A-derived C4b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10493671", "map_id": "none", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10456124", "map_id": "none", "name": "CD46:Cell surface:C4b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10456231", "map_id": "none", "name": "Factor I inactivates MCP/CR1-bound C4b/C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10456132", "map_id": "none", "name": "CFI:CD46, CR1:C4b, C3b complexes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VYR4", "map_id": "Q9VYR4", "name": "fw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001083", "map_id": "FBgn0001083", "name": "fw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q09101", "map_id": "Q09101", "name": "hig", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010114", "map_id": "FBgn0010114", "name": "hig", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10456228", "map_id": "none", "name": "C4c, C3f", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10456186", "map_id": "none", "name": "C4d, iC3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10456188", "map_id": "none", "name": "CD46, CR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10456134", "map_id": "none", "name": "Complement factor I binds to MCP, CR1:C4b, C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10456130", "map_id": "none", "name": "CD46, CR1:C4b:C3b complexes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10468164", "map_id": "none", "name": "Factor I cleaves iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10468123", "map_id": "none", "name": "CR1:iC3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10468161", "map_id": "none", "name": "Homologues of C3dg", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10468149", "map_id": "none", "name": "C3c", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10456075", "map_id": "none", "name": "Homologues of CR1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10488811", "map_id": "none", "name": "CR2 binds C3d, C3dg, iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10488807", "map_id": "none", "name": "C3d, C3dg, iC3b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10488805", "map_id": "Q9VYR4", "name": "fw", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10488809", "map_id": "none", "name": "CR2:C3d,C3dg,iC3b", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10459709", "map_id": "none", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500594", "map_id": "CHEBI:17855", "name": "TAG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10459706", "map_id": "none", "name": "DGAT1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10479149", "map_id": "none", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5696449", "map_id": "CHEBI:17408", "name": "MAG", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_6782195", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10465868", "map_id": "none", "name": "Homologues of AWAT2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10459644", "map_id": "none", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498728", "map_id": "CHEBI:17389", "name": "2-MAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10459639", "map_id": "none", "name": "PNPLA2/3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10459642", "map_id": "none", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10459672", "map_id": "none", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10459686", "map_id": "none", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10487933", "map_id": "none", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10487930", "map_id": "none", "name": "DGAT2L6,L7P", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10459690", "map_id": "none", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524083", "map_id": "CHEBI:16038", "name": "PE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1498773", "map_id": "CHEBI:60430", "name": "MLCL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524072", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524089", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10459677", "map_id": "Q9V6G5", "name": "Taz", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0026619", "map_id": "FBgn0026619", "name": "Taz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459683", "map_id": "none", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524079", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_1524075", "map_id": "CHEBI:16110", "name": "PC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10459667", "map_id": "none", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524038", "map_id": "CHEBI:17984", "name": "acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10459664", "map_id": "none", "name": "HADH octamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10479135", "map_id": "none", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696414", "map_id": "CHEBI:17553", "name": "PETA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113532", "map_id": "CHEBI:15343", "name": "CH3CHO", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10479132", "map_id": "none", "name": "PXLP-K278-ETNPPL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10459804", "map_id": "none", "name": "PETA is dephosphorylated to ETA by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1498751", "map_id": "CHEBI:16000", "name": "ETA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10459801", "map_id": "none", "name": "PHOSPHO1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VWF3", "map_id": "Q9VWF3", "name": "CG14122", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031045", "map_id": "FBgn0031045", "name": "CG14122", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWF0", "map_id": "Q9VWF0", "name": "Dmel\\CG12237", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031048", "map_id": "FBgn0031048", "name": "Dmel\\CG12237", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459850", "map_id": "none", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1500603", "map_id": "CHEBI:16732", "name": "CDP-ETA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10459847", "map_id": "none", "name": "PCYT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VK25", "map_id": "Q9VK25", "name": "Pect", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032482", "map_id": "FBgn0032482", "name": "Pect", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459861", "map_id": "none", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426755", "map_id": "CHEBI:16337", "name": "PA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10459858", "map_id": "none", "name": "LPIN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8SXP0", "map_id": "Q8SXP0", "name": "Lpin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459733", "map_id": "none", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10459730", "map_id": "none", "name": "EPT1:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VIU4", "map_id": "Q9VIU4", "name": "Dmel\\CG33116", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053116", "map_id": "FBgn0053116", "name": "Dmel\\CG33116", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T0S3", "map_id": "Q8T0S3", "name": "cpt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031948", "map_id": "FBgn0031948", "name": "cpt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459873", "map_id": "none", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459870", "map_id": "none", "name": "CHK/ETNK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IMF4", "map_id": "Q8IMF4", "name": "Dmel\\CG2201", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032955", "map_id": "FBgn0032955", "name": "Dmel\\CG2201", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P54352", "map_id": "P54352", "name": "eas", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000536", "map_id": "FBgn0000536", "name": "eas", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459743", "map_id": "none", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426955", "map_id": "CHEBI:17962", "name": "CDP-DAG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10459740", "map_id": "none", "name": "CDIPT:Mg2+/Mn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8SX37", "map_id": "Q8SX37", "name": "Pis", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030670", "map_id": "FBgn0030670", "name": "Pis", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459814", "map_id": "none", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10459811", "map_id": "none", "name": "CDS1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "P56079", "map_id": "P56079", "name": "Cds", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490382", "map_id": "none", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1602448", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10490379", "map_id": "none", "name": "PITPNM1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P43125", "map_id": "P43125", "name": "rdgB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003218", "map_id": "FBgn0003218", "name": "rdgB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459764", "map_id": "none", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524042", "map_id": "CHEBI:17517", "name": "PG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10459585", "map_id": "Q8MZC4", "name": "CLS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0039360", "map_id": "FBgn0039360", "name": "CLS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479092", "map_id": "none", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_5696066", "map_id": "none", "name": "MAG,DAG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_5696069", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5696026", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_5696037", "map_id": "none", "name": "LPA,PA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "species_1500590", "map_id": "CHEBI:16337", "name": "PA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10479089", "map_id": "none", "name": "AGK:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9VL10", "map_id": "Q9VL10", "name": "Mulk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260750", "map_id": "FBgn0260750", "name": "Mulk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459840", "map_id": "none", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_426925", "map_id": "CHEBI:16110", "name": "PC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1500646", "map_id": "CHEBI:18303", "name": "PS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10459837", "map_id": "Q9VPD3", "name": "Pss", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0287585", "map_id": "FBgn0287585", "name": "Pss", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490948", "map_id": "none", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8874447", "map_id": "none", "name": "PMCHO, PMETAM", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:17810", "map_id": "CHEBI:17810", "name": "CHEBI:17810", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17476", "map_id": "CHEBI:17476", "name": "CHEBI:17476", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8874450", "map_id": "none", "name": "GPCHO, GPETAM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "CHEBI:36313", "map_id": "CHEBI:36313", "name": "CHEBI:36313", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36314", "map_id": "CHEBI:36314", "name": "CHEBI:36314", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5696116", "map_id": "CHEBI:35746", "name": "fatty aldehyde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10490945", "map_id": "Q9VAJ0", "name": "Dmel\\CG7582", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0039681", "map_id": "FBgn0039681", "name": "Dmel\\CG7582", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459577", "map_id": "none", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_975614", "map_id": "CHEBI:16728", "name": "2-acyl LPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10459574", "map_id": "none", "name": "LPCAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VVX5", "map_id": "Q9VVX5", "name": "nes", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026630", "map_id": "FBgn0026630", "name": "nes", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0KHU5", "map_id": "Q0KHU5", "name": "LPCAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052699", "map_id": "FBgn0052699", "name": "LPCAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6NN55", "map_id": "Q6NN55", "name": "oys", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033476", "map_id": "FBgn0033476", "name": "oys", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459688", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524028", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10459652", "map_id": "none", "name": "PLA2G2A:Ca2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q8IML0", "map_id": "Q8IML0", "name": "Dmel\\CG14507", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039655", "map_id": "FBgn0039655", "name": "Dmel\\CG14507", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460328", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602390", "map_id": "CHEBI:17504", "name": "1-acyl LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602366", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10460293", "map_id": "none", "name": "PLA2(16)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9W3I8", "map_id": "Q9W3I8", "name": "GIIIspla2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030013", "map_id": "FBgn0030013", "name": "GIIIspla2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYG9", "map_id": "Q9VYG9", "name": "CG4346", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250862", "map_id": "FBgn0250862", "name": "CG4346", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JX94", "map_id": "Q7JX94", "name": "CG1672", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050503", "map_id": "FBgn0050503", "name": "CG1672", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4I0", "map_id": "Q9W4I0", "name": "Dmel\\CG3009", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029720", "map_id": "FBgn0029720", "name": "Dmel\\CG3009", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6XPX3", "map_id": "Q6XPX3", "name": "sPLA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033170", "map_id": "FBgn0033170", "name": "sPLA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUV6", "map_id": "Q9VUV6", "name": "GXIVsPLA2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036545", "map_id": "FBgn0036545", "name": "GXIVsPLA2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460311", "map_id": "none", "name": "Homologues of PLA2R1(21-?)", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "O46197", "map_id": "O46197", "name": "Acp29AB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015583", "map_id": "FBgn0015583", "name": "Acp29AB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPS3", "map_id": "Q9VPS3", "name": "Dmel\\CG2839", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031273", "map_id": "FBgn0031273", "name": "Dmel\\CG2839", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6GV06", "map_id": "Q6GV06", "name": "lectin-30A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040097", "map_id": "FBgn0040097", "name": "lectin-30A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459591", "map_id": "none", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10460326", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10459698", "map_id": "none", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10459695", "map_id": "Q7KUD4", "name": "iPLA2-VIA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036053", "map_id": "FBgn0036053", "name": "iPLA2-VIA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459613", "map_id": "none", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498730", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_1483256", "map_id": "CHEBI:17517", "name": "PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10432542", "map_id": "Q0KHU5", "name": "LPCAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10459580", "map_id": "none", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498740", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10459658", "map_id": "none", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524027", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10460313", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602402", "map_id": "CHEBI:17517", "name": "PG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_1602415", "map_id": "CHEBI:62747", "name": "1-acyl LPG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10459716", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10459588", "map_id": "none", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_1524047", "map_id": "CHEBI:27923", "name": "2-acyl LPG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10459714", "map_id": "none", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10459604", "map_id": "Q8IML0", "name": "Dmel\\CG14507", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10459599", "map_id": "none", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498733", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10459596", "map_id": "Q9VMD5", "name": "frj", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0031815", "map_id": "FBgn0031815", "name": "frj", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459610", "map_id": "none", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498737", "map_id": "CHEBI:62746", "name": "2-acyl LPI", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10459700", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10460321", "map_id": "none", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602420", "map_id": "CHEBI:28914", "name": "1-acyl LPI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10460316", "map_id": "none", "name": "PLA2(15)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10459646", "map_id": "none", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1500604", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10459832", "map_id": "none", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10459827", "map_id": "B7YZT5", "name": "Pld", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10459607", "map_id": "none", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_1500580", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_1524103", "map_id": "CHEBI:57560", "name": "LCFA(-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10481009", "map_id": "none", "name": "LIPH, I hydrolyse PA to 2-acyl LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_6792472", "map_id": "CHEBI:17936", "name": "2-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10481006", "map_id": "none", "name": "LIPH, I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453360", "map_id": "none", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10432535", "map_id": "Q9VRC1", "name": "GPAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0031132", "map_id": "FBgn0031132", "name": "GPAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459662", "map_id": "none", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "reaction_10460330", "map_id": "none", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602447", "map_id": "CHEBI:16975", "name": "1-acyl LPA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10495095", "map_id": "none", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_189422", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_8954419", "map_id": "CHEBI:28494", "name": "cardiolipin", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10495077", "map_id": "none", "name": "PLD6 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9VKD7", "map_id": "Q9VKD7", "name": "zuc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261266", "map_id": "FBgn0261266", "name": "zuc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495093", "map_id": "none", "name": "MIGA complexes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9W3F7", "map_id": "Q9W3F7", "name": "Miga", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030037", "map_id": "FBgn0030037", "name": "Miga", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459655", "map_id": "none", "name": "PA is hydrolysed to 1-acyl LPA by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10432547", "map_id": "none", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10432544", "map_id": "none", "name": "AGPAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VRC1", "map_id": "Q9VRC1", "name": "GPAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D5AEK7", "map_id": "D5AEK7", "name": "Agpat3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036623", "map_id": "FBgn0036623", "name": "Agpat3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VV49", "map_id": "Q9VV49", "name": "Agpat4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036622", "map_id": "FBgn0036622", "name": "Agpat4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432609", "map_id": "none", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432606", "map_id": "none", "name": "GPD1/GPD1L homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P13706", "map_id": "P13706", "name": "Gpdh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001128", "map_id": "FBgn0001128", "name": "Gpdh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1U3", "map_id": "Q9W1U3", "name": "Gpdh2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034825", "map_id": "FBgn0034825", "name": "Gpdh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IN06", "map_id": "Q8IN06", "name": "Gpdh3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263048", "map_id": "FBgn0263048", "name": "Gpdh3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493857", "map_id": "none", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2173763", "map_id": "CHEBI:60479", "name": "lysoPC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8952253", "map_id": "CHEBI:16870", "name": "GPCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10493854", "map_id": "none", "name": "Homologues of PLA2G15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10460319", "map_id": "none", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602419", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10459660", "map_id": "none", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498722", "map_id": "CHEBI:37646", "name": "2-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10459617", "map_id": "none", "name": "LPSAT", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10459669", "map_id": "none", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498724", "map_id": "CHEBI:52603", "name": "1-acyl LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10459620", "map_id": "none", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10459704", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498738", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10459623", "map_id": "none", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1498729", "map_id": "CHEBI:28936", "name": "2-acyl LPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10479047", "map_id": "none", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5694568", "map_id": "CHEBI:61232", "name": "NAPE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5694580", "map_id": "CHEBI:52571", "name": "GPAEA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_5694567", "map_id": "CHEBI:22221", "name": "acyl group", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10479044", "map_id": "Q5U191", "name": "puml", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0033226", "map_id": "FBgn0033226", "name": "puml", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459702", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10460323", "map_id": "none", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1602372", "map_id": "CHEBI:29017", "name": "1-acyl LPE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10459648", "map_id": "none", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10459787", "map_id": "none", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_1524071", "map_id": "CHEBI:36700", "name": "PCho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1524060", "map_id": "CHEBI:16436", "name": "CDP-Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10459784", "map_id": "none", "name": "PCYT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9W0D9", "map_id": "Q9W0D9", "name": "Pcyt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035231", "map_id": "FBgn0035231", "name": "Pcyt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K4C7", "map_id": "Q7K4C7", "name": "Pcyt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041342", "map_id": "FBgn0041342", "name": "Pcyt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10443498", "map_id": "none", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_264643", "map_id": "CHEBI:15355", "name": "AcCho", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10443495", "map_id": "P07668", "name": "ChAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0000303", "map_id": "FBgn0000303", "name": "ChAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459817", "map_id": "none", "name": "PCho is dephosphorylated to Cho by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10491447", "map_id": "none", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10491443", "map_id": "Q9VJZ2", "name": "Dmel\\CG6565", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "FBgn0032513", "map_id": "FBgn0032513", "name": "Dmel\\CG6565", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491445", "map_id": "none", "name": "STARD7:PC", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VJZ2", "map_id": "Q9VJZ2", "name": "Dmel\\CG6565", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479012", "map_id": "none", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5694502", "map_id": "CHEBI:64483", "name": "LPC(14:0)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_5694457", "map_id": "CHEBI:11230", "name": "1AGPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10479009", "map_id": "A1Z7Q7", "name": "Hydr1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0033382", "map_id": "FBgn0033382", "name": "Hydr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459761", "map_id": "none", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459758", "map_id": "none", "name": "CHK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465406", "map_id": "none", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2213221", "map_id": "none", "name": "Antigen", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_2213225", "map_id": "none", "name": "unfolded antigen", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10465403", "map_id": "none", "name": "Homologues of IFI30", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9VCK1", "map_id": "Q9VCK1", "name": "GILT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039099", "map_id": "FBgn0039099", "name": "GILT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95RA9", "map_id": "Q95RA9", "name": "GILT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038149", "map_id": "FBgn0038149", "name": "GILT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHA5", "map_id": "Q9VHA5", "name": "Dmel\\CG9427", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037721", "map_id": "FBgn0037721", "name": "Dmel\\CG9427", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCK2", "map_id": "Q9VCK2", "name": "GILT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039098", "map_id": "FBgn0039098", "name": "GILT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465008", "map_id": "none", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_2213226", "map_id": "none", "name": "MHC class II epitopes", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10465005", "map_id": "none", "name": "Cathepsin", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9VN93", "map_id": "Q9VN93", "name": "CTSW", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260462", "map_id": "FBgn0260462", "name": "CTSW", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431263", "map_id": "none", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111354", "map_id": "CHEBI:18272", "name": "N-Formyl-GAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111369", "map_id": "CHEBI:18413", "name": "FGAM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431260", "map_id": "P35421", "name": "Pfas", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0000052", "map_id": "FBgn0000052", "name": "Pfas", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10434110", "map_id": "none", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434106", "map_id": "none", "name": "PPAT tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27601", "map_id": "Q27601", "name": "Prat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004901", "map_id": "FBgn0004901", "name": "Prat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17909", "map_id": "CHEBI:17909", "name": "CHEBI:17909", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10431276", "map_id": "none", "name": "PPAT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431198", "map_id": "none", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431195", "map_id": "Q9VIE7", "name": "bur", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0000239", "map_id": "FBgn0000239", "name": "bur", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10434142", "map_id": "none", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35141", "map_id": "CHEBI:15919", "name": "ADS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10434139", "map_id": "none", "name": "ADSS, ADSSL1 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9Y0Y2", "map_id": "Q9Y0Y2", "name": "AdSS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027493", "map_id": "FBgn0027493", "name": "AdSS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10434108", "map_id": "none", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10431224", "map_id": "none", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_419151", "map_id": "CHEBI:15637", "name": "10-formyl-THF", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111409", "map_id": "CHEBI:18406", "name": "AICAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111427", "map_id": "CHEBI:18381", "name": "FAICAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431218", "map_id": "none", "name": "ATIC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VC18", "map_id": "Q9VC18", "name": "BEST:GH11240", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039241", "map_id": "FBgn0039241", "name": "BEST:GH11240", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431255", "map_id": "none", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111370", "map_id": "CHEBI:28843", "name": "AIR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431252", "map_id": "P00967", "name": "Gart", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0000053", "map_id": "FBgn0000053", "name": "Gart", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498472", "map_id": "none", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678719", "map_id": "none", "name": "IMPDH inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431205", "map_id": "none", "name": "IMPDH1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q07152", "map_id": "Q07152", "name": "ras", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003204", "map_id": "FBgn0003204", "name": "ras", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10431208", "map_id": "none", "name": "IMPDH tetramers:IMPDH inhibitors", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10431221", "map_id": "none", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10431281", "map_id": "none", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29586", "map_id": "CHEBI:37154", "name": "FUMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431231", "map_id": "none", "name": "ADSL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VEP6", "map_id": "Q9VEP6", "name": "AdSL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038467", "map_id": "FBgn0038467", "name": "AdSL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431279", "map_id": "none", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111292", "map_id": "CHEBI:17284", "name": "PRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10431247", "map_id": "none", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111395", "map_id": "CHEBI:28413", "name": "CAIR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431241", "map_id": "none", "name": "PAICS octamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9I7S8", "map_id": "Q9I7S8", "name": "Paics", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020513", "map_id": "FBgn0020513", "name": "Paics", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431244", "map_id": "none", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111399", "map_id": "CHEBI:18319", "name": "SAICAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10431210", "map_id": "none", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10431269", "map_id": "none", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111338", "map_id": "CHEBI:18349", "name": "PRGA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10431266", "map_id": "none", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10431234", "map_id": "none", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10498768", "map_id": "none", "name": "HMOX1 translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497417", "map_id": "Q9VGJ9", "name": "Ho", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0037933", "map_id": "FBgn0037933", "name": "Ho", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498766", "map_id": "Q9VGJ9", "name": "Ho", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10498774", "map_id": "none", "name": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439555", "map_id": "none", "name": "HMOX1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VGJ9", "map_id": "Q9VGJ9", "name": "Ho", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498772", "map_id": "none", "name": "HMOX1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10498760", "map_id": "none", "name": "HM13 cleaves HMOX1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10498757", "map_id": "Q9VPQ7", "name": "Spp", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0031260", "map_id": "FBgn0031260", "name": "Spp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498762", "map_id": "none", "name": "BACH1 translocates from the nucleoplasm to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498736", "map_id": "Q9VYJ8", "name": "Dmel\\CG15725", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10498744", "map_id": "Q9VYJ8", "name": "Dmel\\CG15725", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_3785707", "map_id": "CHEBI:26523", "name": "ROS", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10491908", "map_id": "none", "name": "NFE2L2 binds KEAP1:CUL3:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491902", "map_id": "P20482", "name": "cnc", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0262975", "map_id": "FBgn0262975", "name": "phospho-cnc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491904", "map_id": "none", "name": "KEAP1:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KSF5", "map_id": "Q7KSF5", "name": "Keap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038475", "map_id": "FBgn0038475", "name": "Keap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491906", "map_id": "none", "name": "KEAP1:CUL3:RBX1:NFE2L2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P20482", "map_id": "P20482", "name": "phospho-cnc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498789", "map_id": "none", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9714134", "map_id": "none", "name": "NFE2L2 inducers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10498787", "map_id": "none", "name": "NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10491912", "map_id": "none", "name": "KEAP1:CUL3:RBX1:NFE2L2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491910", "map_id": "none", "name": "2 x KEAP1:CUL3:RBX1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10491900", "map_id": "none", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491892", "map_id": "none", "name": "p-NFE2L2", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10491898", "map_id": "none", "name": "p-NFE2L2", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10491917", "map_id": "none", "name": "KEAP1 facilitates ubiquitination of NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491914", "map_id": "none", "name": "Ub-NFE2L2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10491919", "map_id": "none", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10439548", "map_id": "none", "name": "BLVRA:Zn2+, BLVRB reduce BV to BIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189396", "map_id": "CHEBI:17033", "name": "BV", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_189386", "map_id": "CHEBI:16990", "name": "BIL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439545", "map_id": "Q9VH72", "name": "BVR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0037749", "map_id": "FBgn0037749", "name": "BVR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439562", "map_id": "none", "name": "HMOX1 dimer, HMOX2 cleave heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189385", "map_id": "CHEBI:17245", "name": "CO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439559", "map_id": "none", "name": "HMOX1 dimer, HMOX2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10436293", "map_id": "none", "name": "Electron transfer from reduced cytochrome c to molecular oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10436237", "map_id": "none", "name": "Cytochrome c oxidase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P00399", "map_id": "P00399", "name": "mt:CoI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013674", "map_id": "FBgn0013674", "name": "mt:CoI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VP19", "map_id": "Q9VP19", "name": "COX8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263911", "map_id": "FBgn0263911", "name": "COX8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMB9", "map_id": "Q9VMB9", "name": "COX5B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031830", "map_id": "FBgn0031830", "name": "COX5B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94514", "map_id": "Q94514", "name": "COX5A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019624", "map_id": "FBgn0019624", "name": "COX5A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T4H8", "map_id": "Q8T4H8", "name": "COX4L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033020", "map_id": "FBgn0033020", "name": "COX4L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIQ8", "map_id": "Q9VIQ8", "name": "COX4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032833", "map_id": "FBgn0032833", "name": "COX4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWD1", "map_id": "Q9VWD1", "name": "COX6B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031066", "map_id": "FBgn0031066", "name": "COX6B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SYJ2", "map_id": "Q8SYJ2", "name": "ND-MLRQ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052230", "map_id": "FBgn0052230", "name": "ND-MLRQ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1N3", "map_id": "Q9W1N3", "name": "levy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034877", "map_id": "FBgn0034877", "name": "levy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P00417", "map_id": "P00417", "name": "mt:CoIII", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013676", "map_id": "FBgn0013676", "name": "mt:CoIII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P00408", "map_id": "P00408", "name": "mt:CoII", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013675", "map_id": "FBgn0013675", "name": "mt:CoII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28694", "map_id": "CHEBI:28694", "name": "CHEBI:28694", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHR9", "map_id": "Q9VHR9", "name": "COX7AL", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037579", "map_id": "FBgn0037579", "name": "COX7AL", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6IHY5", "map_id": "Q6IHY5", "name": "Dmel\\CG34172", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085201", "map_id": "FBgn0085201", "name": "Dmel\\CG34172", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHS2", "map_id": "Q9VHS2", "name": "COX7A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040529", "map_id": "FBgn0040529", "name": "COX7A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JW00", "map_id": "Q7JW00", "name": "COX7C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040773", "map_id": "FBgn0040773", "name": "COX7C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436243", "map_id": "E1JGR4", "name": "Dmel\\CG42496", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "FBgn0260222", "map_id": "FBgn0260222", "name": "Dmel\\CG42496", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436265", "map_id": "none", "name": "COX11,14,16,18,20", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VF98", "map_id": "Q9VF98", "name": "l(3)neo43", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011476", "map_id": "FBgn0011476", "name": "l(3)neo43", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMQ6", "map_id": "Q9VMQ6", "name": "CG6922", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051648", "map_id": "FBgn0051648", "name": "CG6922", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VST8", "map_id": "Q9VST8", "name": "Dmel\\CG4942", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035960", "map_id": "FBgn0035960", "name": "Dmel\\CG4942", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VG00", "map_id": "Q9VG00", "name": "l(3)87Df", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002354", "map_id": "FBgn0002354", "name": "l(3)87Df", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436289", "map_id": "none", "name": "COX ancilliary proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VL11", "map_id": "Q9VL11", "name": "Dmel\\CG4957", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032205", "map_id": "FBgn0032205", "name": "Dmel\\CG4957", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ86", "map_id": "Q9VJ86", "name": "bsf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0284256", "map_id": "FBgn0284256", "name": "bsf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U4F3", "map_id": "Q9U4F3", "name": "Surf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029117", "map_id": "FBgn0029117", "name": "Surf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMX4", "map_id": "Q9VMX4", "name": "Scox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262467", "map_id": "FBgn0262467", "name": "Scox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436291", "map_id": "none", "name": "Cytochrome c oxidase:CO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_9709326", "map_id": "CHEBI:17245", "name": "CO", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10498783", "map_id": "none", "name": "CO binds to Cytochrome c oxidase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "reaction_10498367", "map_id": "none", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10445949", "map_id": "none", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10445937", "map_id": "A8JR46", "name": "Ire1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0261984", "map_id": "FBgn0261984", "name": "phospho-Ire1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445939", "map_id": "none", "name": "IRE1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "A8JR46", "map_id": "A8JR46", "name": "phospho-Ire1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445947", "map_id": "none", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10445944", "map_id": "none", "name": "p-S724-IRE1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10498384", "map_id": "none", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498382", "map_id": "none", "name": "BIL:GSTA1, FABP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498386", "map_id": "none", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10498370", "map_id": "none", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5679042", "map_id": "none", "name": "BMG,BDG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:18392", "map_id": "CHEBI:18392", "name": "CHEBI:18392", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:16427", "map_id": "CHEBI:16427", "name": "CHEBI:16427", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5679034", "map_id": "none", "name": "BMG,BDG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10455124", "map_id": "none", "name": "ABCG2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498375", "map_id": "none", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10498372", "map_id": "Q9VLB3", "name": "Oatp30B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10498380", "map_id": "none", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498377", "map_id": "Q9VLB3", "name": "Oatp30B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10498365", "map_id": "none", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10486017", "map_id": "none", "name": "RNF34 or RFFL ubiquitinates phosphorylated TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486010", "map_id": "none", "name": "PolyUb,p-S15,S20-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10486012", "map_id": "A1Z971", "name": "dRNF34", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0033783", "map_id": "FBgn0033783", "name": "dRNF34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10481097", "map_id": "none", "name": "Ubiquitinated TP53 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467609", "map_id": "none", "name": "PolyUb-TP53 Tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10481095", "map_id": "none", "name": "PolyUb-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10467619", "map_id": "none", "name": "USP7 deubiquitinates TP53 and counteracts MDM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10495584", "map_id": "none", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495580", "map_id": "none", "name": "NGB:ferroheme b:O2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VF15", "map_id": "Q9VF15", "name": "glob1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027657", "map_id": "FBgn0027657", "name": "glob1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495578", "map_id": "none", "name": "NGB:ferroheme b", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495582", "map_id": "none", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10471496", "map_id": "none", "name": "MeSeO2H is reduced to MeSeOH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357694", "map_id": "CHEBI:77012", "name": "MeSeO2H", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5357663", "map_id": "CHEBI:77062", "name": "MeSeOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10471493", "map_id": "none", "name": "MeSeOH is reduced to MeSeH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357669", "map_id": "CHEBI:64685", "name": "MeSeH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10464075", "map_id": "none", "name": "Calcineurin binds NFATC1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10464073", "map_id": "none", "name": "Calcineurin:p-NFATC1,2,3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498551", "map_id": "none", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678991", "map_id": "none", "name": "tacrolimus", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10498549", "map_id": "none", "name": "FKBP1A:tacrolimus", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495732", "map_id": "none", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495726", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10495730", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495748", "map_id": "none", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495746", "map_id": "none", "name": "p-Y-STAT3:p-STAT5A,p-STAT5B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495777", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495769", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10495775", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495763", "map_id": "none", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495759", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10495761", "map_id": "none", "name": "p-Y-STAT1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495767", "map_id": "none", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495765", "map_id": "none", "name": "p-STAT5A,p-STAT5B dimer", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10495771", "map_id": "none", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10458684", "map_id": "none", "name": "Activation of HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458681", "map_id": "none", "name": "HCN channel bound to cAMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A1Z9N7", "map_id": "A1Z9N7", "name": "Ih", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263397", "map_id": "FBgn0263397", "name": "Ih", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458851", "map_id": "none", "name": "Binding of cAMP to HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458679", "map_id": "none", "name": "HCN channels", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10476866", "map_id": "none", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10437505", "map_id": "none", "name": "K63-Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10476863", "map_id": "none", "name": "ATXN3,ATXN3L,JOSD1,JOSD2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W422", "map_id": "Q9W422", "name": "JOSD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029853", "map_id": "FBgn0029853", "name": "JOSD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477104", "map_id": "none", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10456711", "map_id": "Q7KTX7", "name": "park", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0041100", "map_id": "FBgn0041100", "name": "park", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476869", "map_id": "Q7KTX7", "name": "park", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10459500", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10459493", "map_id": "none", "name": "CA1,2,3,7,13:Zinc", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10459498", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10459454", "map_id": "none", "name": "CA4,9,14,12:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9V9Y6", "map_id": "Q9V9Y6", "name": "CAH5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040629", "map_id": "FBgn0040629", "name": "CAH5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IMV4", "map_id": "Q8IMV4", "name": "CAH4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039235", "map_id": "FBgn0039235", "name": "CAH4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V4S9", "map_id": "Q4V4S9", "name": "CAH8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038956", "map_id": "FBgn0038956", "name": "CAH8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTU8", "map_id": "Q9VTU8", "name": "CAH2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027843", "map_id": "FBgn0027843", "name": "CAH2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB76", "map_id": "Q9VB76", "name": "CAH9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039486", "map_id": "FBgn0039486", "name": "CAH9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9Y8", "map_id": "Q9V9Y8", "name": "CAH6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039838", "map_id": "FBgn0039838", "name": "CAH6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10459496", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10459523", "map_id": "none", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_29896", "map_id": "CHEBI:17544", "name": "HCO3-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10459518", "map_id": "none", "name": "CA5A,B:Zinc", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10458226", "map_id": "none", "name": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10458223", "map_id": "none", "name": "CA6:Zinc", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10459457", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10459521", "map_id": "none", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10458241", "map_id": "none", "name": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10444363", "map_id": "none", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444322", "map_id": "none", "name": "Docked acetylcholine loaded Synaptic Vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10444360", "map_id": "O17444", "name": "VAChT", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10443019", "map_id": "none", "name": "SNARE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444325", "map_id": "none", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10443487", "map_id": "none", "name": "Acetylcholine Loaded Synaptic Vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10443490", "map_id": "none", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_372511", "map_id": "CHEBI:15378", "name": "H+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_372525", "compartment_display": "clathrin-sculpted acetylcholine transport vesicle lumen", "complex": "false" }, { "id": "species_10443485", "map_id": "none", "name": "Empty Acetylcholine Synaptic Vesicle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10443479", "map_id": "O17444", "name": "VAChT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_373334", "compartment_display": "clathrin-sculpted acetylcholine transport vesicle membrane", "complex": "false" }, { "id": "reaction_10427772", "map_id": "none", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427770", "map_id": "none", "name": "Ub-p-S123-CDC25A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10427800", "map_id": "none", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10498677", "map_id": "none", "name": "MLKL binds HSP90:CDC37", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471010", "map_id": "P11346", "name": "Raf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10462118", "map_id": "none", "name": "CDC37", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10462120", "map_id": "none", "name": "HSP90", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10498675", "map_id": "none", "name": "MLKL:HSP90:CDC37", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476089", "map_id": "none", "name": "BIRC2/3 (cIAP1/2) is autoubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471711", "map_id": "none", "name": "BIRC2,3,4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10476086", "map_id": "none", "name": "K48pUb- BIRC2,3,4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440446", "map_id": "none", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10440408", "map_id": "Q8INK3", "name": "fabp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_192483", "map_id": "none", "name": "bile salts and acids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10440410", "map_id": "none", "name": "bile salts and acids:FABP6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16525", "map_id": "CHEBI:16525", "name": "CHEBI:16525", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10440422", "map_id": "none", "name": "Homologues of SLC10A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10440444", "map_id": "none", "name": "NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471675", "map_id": "none", "name": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10440435", "map_id": "none", "name": "NR1H4:DCA,CDCA,LCHA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471673", "map_id": "none", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10440433", "map_id": "P34021", "name": "EcR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_5340249", "map_id": "none", "name": "DCA,CDCA,LCHA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10435765", "map_id": "none", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_194096", "map_id": "none", "name": "cholate; chenodeoxycholate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_194073", "map_id": "none", "name": "choloyl-CoA; chenodeoxycholoyl-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15519", "map_id": "CHEBI:15519", "name": "CHEBI:15519", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28701", "map_id": "CHEBI:28701", "name": "CHEBI:28701", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458872", "map_id": "none", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458869", "map_id": "none", "name": "TASK", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10491685", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10491672", "map_id": "none", "name": "GGC-RAB18:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V8W3", "map_id": "Q9V8W3", "name": "Rep", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026378", "map_id": "FBgn0026378", "name": "Rep", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLB7", "map_id": "Q9VLB7", "name": "Gdi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004868", "map_id": "FBgn0004868", "name": "Gdi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4A0", "map_id": "Q9W4A0", "name": "Rab18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015794", "map_id": "FBgn0015794", "name": "Rab18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491676", "map_id": "none", "name": "GGC-RAB18:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10491105", "map_id": "none", "name": "GDIs,CHMs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491682", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VKB9", "map_id": "Q9VKB9", "name": "Rab3-GAP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027505", "map_id": "FBgn0027505", "name": "Rab3-GAP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQ26", "map_id": "Q9VQ26", "name": "RAB3GAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051935", "map_id": "FBgn0051935", "name": "RAB3GAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491494", "map_id": "none", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10491471", "map_id": "none", "name": "GGC-RAB7:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491477", "map_id": "none", "name": "GGC-RAB7:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10491491", "map_id": "none", "name": "MON1:CCZ1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VZL5", "map_id": "Q9VZL5", "name": "Ccz1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035470", "map_id": "FBgn0035470", "name": "Ccz1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR38", "map_id": "Q9VR38", "name": "Mon1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031640", "map_id": "FBgn0031640", "name": "Mon1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491114", "map_id": "none", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane" }, { "id": "species_10491107", "map_id": "none", "name": "GGC-RAB3A:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491111", "map_id": "none", "name": "GGC-RAB3A:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "species_10474299", "map_id": "Q9VXY2", "name": "Rab3-GEF", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030613", "map_id": "FBgn0030613", "name": "Rab3-GEF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491402", "map_id": "none", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491388", "map_id": "none", "name": "GGC-RAB14:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86BK8", "map_id": "Q86BK8", "name": "Rab14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015791", "map_id": "FBgn0015791", "name": "Rab14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491392", "map_id": "none", "name": "GGC-RAB14:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10491397", "map_id": "Q9W4D1", "name": "BEST:LD39762", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0029756", "map_id": "FBgn0029756", "name": "BEST:LD39762", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491435", "map_id": "none", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10491424", "map_id": "none", "name": "GGC-RAB21:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7PLE9", "map_id": "Q7PLE9", "name": "Rab21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039966", "map_id": "FBgn0039966", "name": "Rab21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491428", "map_id": "none", "name": "GGC-RAB21:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10491430", "map_id": "Q9VGH9", "name": "Sbf", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10491467", "map_id": "none", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_10491455", "map_id": "none", "name": "GGC-RAB27:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O76901", "map_id": "O76901", "name": "Rab27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025382", "map_id": "FBgn0025382", "name": "Rab27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491465", "map_id": "none", "name": "RAB27:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "reaction_10491217", "map_id": "none", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane" }, { "id": "species_10491201", "map_id": "none", "name": "GGC-RAB10:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O15971", "map_id": "O15971", "name": "Rab10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015789", "map_id": "FBgn0015789", "name": "Rab10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491205", "map_id": "none", "name": "GGC-RAB10:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_10491210", "map_id": "Q9W3D3", "name": "Crag", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0025864", "map_id": "FBgn0025864", "name": "Crag", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491569", "map_id": "none", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10491547", "map_id": "none", "name": "GGC-RAB35:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491551", "map_id": "none", "name": "GGC-RAB35:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10491566", "map_id": "none", "name": "RAB35 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1Z7Q5", "map_id": "A1Z7Q5", "name": "CG30347", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027561", "map_id": "FBgn0027561", "name": "CG30347", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491634", "map_id": "none", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10491618", "map_id": "none", "name": "GGC-RAB39:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491624", "map_id": "none", "name": "GGC-RAB39:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10491629", "map_id": "Q9W0E1", "name": "pns", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035229", "map_id": "FBgn0035229", "name": "pns", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491155", "map_id": "none", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_171062", "compartment_display": "early endosome membrane" }, { "id": "species_10491118", "map_id": "none", "name": "GGC-RAB5:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491126", "map_id": "none", "name": "GGC-RAB5:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_171062", "compartment_display": "early endosome membrane", "complex": "true" }, { "id": "species_10491152", "map_id": "none", "name": "RAB5 GEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VNZ8", "map_id": "Q9VNZ8", "name": "Als2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037116", "map_id": "FBgn0037116", "name": "Als2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQW8", "map_id": "Q8MQW8", "name": "spri", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085443", "map_id": "FBgn0085443", "name": "spri", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZ08", "map_id": "Q9VZ08", "name": "GAPVD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030286", "map_id": "FBgn0030286", "name": "GAPVD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491318", "map_id": "none", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane" }, { "id": "species_10491291", "map_id": "none", "name": "GCC-RAB12:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491313", "map_id": "none", "name": "GGC-RAB12:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_262783", "compartment_display": "recycling endosome membrane", "complex": "true" }, { "id": "species_10491315", "map_id": "none", "name": "DENND3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W3D3", "map_id": "Q9W3D3", "name": "Crag", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491543", "map_id": "none", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane" }, { "id": "species_10491502", "map_id": "none", "name": "GGC-RAB1:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491516", "map_id": "none", "name": "GGC-RAB1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13946", "compartment_display": "transport vesicle membrane", "complex": "true" }, { "id": "species_10491540", "map_id": "none", "name": "TRAPPCs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IRE3", "map_id": "Q8IRE3", "name": "gry", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286567", "map_id": "FBgn0286567", "name": "gry", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPB6", "map_id": "Q9VPB6", "name": "Dmel\\CG11396", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037022", "map_id": "FBgn0037022", "name": "Dmel\\CG11396", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95TN1", "map_id": "Q95TN1", "name": "TRAPPC13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032204", "map_id": "FBgn0032204", "name": "TRAPPC13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW22", "map_id": "Q9VW22", "name": "l(3)76BDm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260655", "map_id": "FBgn0260655", "name": "l(3)76BDm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491287", "map_id": "none", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491280", "map_id": "Q9W3D3", "name": "Crag", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10491284", "map_id": "Q9W3D3", "name": "phospho-Crag", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475687", "map_id": "Q8MQJ7", "name": "phospho-Atg1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0260945", "map_id": "FBgn0260945", "name": "Atg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491384", "map_id": "none", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_204883", "compartment_display": "cell junction" }, { "id": "species_10491352", "map_id": "none", "name": "GGC-RAB13:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491374", "map_id": "none", "name": "GGC-RAB13:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_204883", "compartment_display": "cell junction", "complex": "true" }, { "id": "species_10491381", "map_id": "none", "name": "RAB13 GEFs", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10491960", "map_id": "none", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491553", "map_id": "A1Z7Q5", "name": "CG30347", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10491559", "map_id": "A1Z7Q5", "name": "phospho-CG30347", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10491962", "map_id": "none", "name": "YWHAE dimer binds phosphorylated DENND1 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491564", "map_id": "none", "name": "p-2S-DENND1A,B:YWHAE dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10491614", "map_id": "none", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane" }, { "id": "species_10491593", "map_id": "none", "name": "RAB32,RAB38:GDP:GDIs,CHMs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1Z7S3", "map_id": "A1Z7S3", "name": "Rab32", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002567", "map_id": "FBgn0002567", "name": "Rab32", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491599", "map_id": "none", "name": "RAB32,RAB38:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5668575", "compartment_display": "melanosome membrane", "complex": "true" }, { "id": "species_10491611", "map_id": "none", "name": "HPS1:HPS4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K3N1", "map_id": "Q7K3N1", "name": "HPS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033973", "map_id": "FBgn0033973", "name": "HPS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAX8", "map_id": "A1ZAX8", "name": "HPS4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034261", "map_id": "FBgn0034261", "name": "HPS4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490413", "map_id": "none", "name": "NPM1 binds TFAP2A homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489710", "map_id": "none", "name": "TFAP2 homo- and heterodimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9PIH9", "map_id": "M9PIH9", "name": "TfAP-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261953", "map_id": "FBgn0261953", "name": "TfAP-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10490411", "map_id": "none", "name": "NPM1:TFAP2A homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q27415", "map_id": "Q27415", "name": "Nlp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428447", "map_id": "none", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70858", "map_id": "CHEBI:27754", "name": "MACR-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_71847", "map_id": "CHEBI:28259", "name": "bHIB-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10428381", "map_id": "none", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70715", "map_id": "CHEBI:15487", "name": "ISV-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_70744", "map_id": "CHEBI:15486", "name": "bMC-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428378", "map_id": "none", "name": "IVD tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VSL9", "map_id": "Q9VSL9", "name": "Dmel\\CG6638", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035911", "map_id": "FBgn0035911", "name": "Dmel\\CG6638", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453146", "map_id": "none", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30004", "map_id": "CHEBI:16256", "name": "2M3OPROA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_573404", "map_id": "CHEBI:11805", "name": "bHIBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428462", "map_id": "none", "name": "HIBADH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9V8M5", "map_id": "Q9V8M5", "name": "HIBADH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034390", "map_id": "FBgn0034390", "name": "HIBADH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428473", "map_id": "none", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70843", "map_id": "CHEBI:15539", "name": "PROP-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428470", "map_id": "Q7KW39", "name": "ALDH6A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0023537", "map_id": "FBgn0023537", "name": "ALDH6A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453144", "map_id": "none", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70836", "map_id": "CHEBI:15476", "name": "2MACA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70829", "map_id": "CHEBI:15449", "name": "aMbHBUT-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428424", "map_id": "none", "name": "HSD17B10 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O18404", "map_id": "O18404", "name": "scu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0021765", "map_id": "FBgn0021765", "name": "scu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428407", "map_id": "none", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70772", "map_id": "CHEBI:15488", "name": "bMC-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_70784", "map_id": "CHEBI:15467", "name": "bHMG-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428404", "map_id": "none", "name": "AUH hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A1Z934", "map_id": "A1Z934", "name": "Dmel\\CG8778", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033761", "map_id": "FBgn0033761", "name": "Dmel\\CG8778", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453142", "map_id": "none", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428394", "map_id": "none", "name": "6x(Btn-MCCC1:MCCC2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10428437", "map_id": "none", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10428371", "map_id": "none", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508190", "map_id": "none", "name": "Leu, Ile, Val", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_508181", "map_id": "none", "name": "KIC, KMVA, KIV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:16530", "map_id": "CHEBI:16530", "name": "CHEBI:16530", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:28654", "map_id": "CHEBI:28654", "name": "CHEBI:28654", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:17865", "map_id": "CHEBI:17865", "name": "CHEBI:17865", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10428368", "map_id": "none", "name": "BCAT2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VYD5", "map_id": "Q9VYD5", "name": "Dmel\\CG1673", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030482", "map_id": "FBgn0030482", "name": "Dmel\\CG1673", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453134", "map_id": "none", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_508187", "map_id": "none", "name": "KIC,KMVA,KIV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_508182", "map_id": "none", "name": "Leu, Ile, Val", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10428360", "map_id": "none", "name": "BCAT1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10428455", "map_id": "none", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428452", "map_id": "Q86BP1", "name": "Dmel\\CG5044", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0038326", "map_id": "FBgn0038326", "name": "Dmel\\CG5044", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428417", "map_id": "none", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70718", "map_id": "CHEBI:15477", "name": "2MBUT-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_70799", "map_id": "CHEBI:15478", "name": "tiglyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428414", "map_id": "none", "name": "ACADSB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VVU1", "map_id": "Q9VVU1", "name": "GH07925p", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036824", "map_id": "FBgn0036824", "name": "GH07925p", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428352", "map_id": "none", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508261", "map_id": "none", "name": "BCAA-CoAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:15479", "map_id": "CHEBI:15479", "name": "CHEBI:15479", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10428349", "map_id": "none", "name": "lipo-BCKDH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q7PLE6", "map_id": "Q7PLE6", "name": "Dmel\\CG17691", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039993", "map_id": "FBgn0039993", "name": "Dmel\\CG17691", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHB8", "map_id": "Q9VHB8", "name": "Dmel\\CG8199", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037709", "map_id": "FBgn0037709", "name": "Dmel\\CG8199", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXY3", "map_id": "Q9VXY3", "name": "Dbct", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030612", "map_id": "FBgn0030612", "name": "Dbct", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430201", "map_id": "none", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10430194", "map_id": "none", "name": "Spliced mRNA:CBC:EJC:TREX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q27268", "map_id": "Q27268", "name": "Hel25E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014189", "map_id": "FBgn0014189", "name": "Hel25E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWQ6", "map_id": "Q9VWQ6", "name": "Dmel\\CG18259", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030956", "map_id": "FBgn0030956", "name": "Dmel\\CG18259", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWQ3", "map_id": "Q9VWQ3", "name": "cg6961", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030959", "map_id": "FBgn0030959", "name": "cg6961", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHC8", "map_id": "Q9VHC8", "name": "Dmel\\CG8149", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037700", "map_id": "FBgn0037700", "name": "Dmel\\CG8149", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHT2", "map_id": "Q9VHT2", "name": "tex", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037569", "map_id": "FBgn0037569", "name": "tex", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRJ8", "map_id": "Q8IRJ8", "name": "thoc7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035110", "map_id": "FBgn0035110", "name": "thoc7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E2QCS8", "map_id": "E2QCS8", "name": "tho2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031390", "map_id": "FBgn0031390", "name": "tho2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTV1", "map_id": "Q9VTV1", "name": "thoc6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036263", "map_id": "FBgn0036263", "name": "thoc6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNI8", "map_id": "Q9VNI8", "name": "Hpr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037382", "map_id": "FBgn0037382", "name": "Hpr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1F4", "map_id": "Q9W1F4", "name": "thoc5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034939", "map_id": "FBgn0034939", "name": "thoc5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAQ7", "map_id": "Q9VAQ7", "name": "Slu7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039626", "map_id": "FBgn0039626", "name": "Slu7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10430196", "map_id": "none", "name": "3' end cleaved, ligated exon containing complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10430198", "map_id": "none", "name": "mRNA 3'-end cleavage factor", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434116", "map_id": "none", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434112", "map_id": "none", "name": "Capped Intronless Histone pre-mRNA:CBC:ZFP100 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10434114", "map_id": "none", "name": "Mature intronless transcript derived Histone pre-mRNA:CBC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10460039", "map_id": "none", "name": "Formation of NRF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10460033", "map_id": "M9NFF9", "name": "Atac3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0052343", "map_id": "FBgn0052343", "name": "Atac3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460035", "map_id": "M9NFF9", "name": "Atac3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10460024", "map_id": "Q04688", "name": "Ets97D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0004510", "map_id": "FBgn0004510", "name": "Ets97D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460029", "map_id": "M9NFF9", "name": "Atac3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10460031", "map_id": "M9NFF9", "name": "Atac3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10460037", "map_id": "none", "name": "NRF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9NFF9", "map_id": "M9NFF9", "name": "Atac3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q04688", "map_id": "Q04688", "name": "Ets97D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476803", "map_id": "none", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428209", "map_id": "none", "name": "GLUD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "P54385", "map_id": "P54385", "name": "Gdh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001098", "map_id": "FBgn0001098", "name": "Gdh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476793", "map_id": "none", "name": "RibC-GLUD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5688274", "map_id": "CHEBI:17154", "name": "NAM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10476800", "map_id": "none", "name": "SIRT4:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q8IRR5", "map_id": "Q8IRR5", "name": "Sirt4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029783", "map_id": "FBgn0029783", "name": "Sirt4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476835", "map_id": "none", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10476821", "map_id": "none", "name": "Ack-ACCS2,AcK-GLUD,AcK-IDH2,Ack-SOD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VP61", "map_id": "Q9VP61", "name": "AcCoAS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0012034", "map_id": "FBgn0012034", "name": "AcCoAS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5688337", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10476825", "map_id": "none", "name": "ACCS2,GLUD,IDH2,SOD2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10476832", "map_id": "none", "name": "SIRT3(?-399):Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9I7I7", "map_id": "Q9I7I7", "name": "Sirt2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038788", "map_id": "FBgn0038788", "name": "Sirt2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493564", "map_id": "none", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10493562", "map_id": "none", "name": "F1Fo ATP synthase dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10458847", "map_id": "none", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458844", "map_id": "none", "name": "TREK homodimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_390116", "map_id": "none", "name": "Phospho FT reduces D accumulation at the plasma membrane", "reversible": "false", "notes": "There are observations that Fat (FT), Dachsous (DS), and Four-jointed (FJ) modulate the subcellular localisation of Dachs (D). In the absence of FT, D accumulates at the plasma membrane. These suggest a simple model whereby signalling through FT regulates the stability of the serine/threonine kinase, Warts (WTS), by reducing protein levels of D at the plasma membrane so it fails to interact with WTS.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_451851", "map_id": "none", "name": "DS:Phospho FT:DCO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q24292", "map_id": "Q24292", "name": "DS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "DS", "map_id": "DS", "name": "DS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P33450", "map_id": "P33450", "name": "Phospho FT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho FT", "map_id": "Phospho FT", "name": "Phospho FT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_451889", "map_id": "Q95VU9", "name": "D", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_390026", "map_id": "Q95VU9", "name": "D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_451856", "map_id": "none", "name": "FT is phosphorylated by DCO", "reversible": "false", "notes": "The casein kinase 1 epsilon orthologue, Discs overgrown (DCO) phosphorylates the cytoplasmic part of FT at unknown residues.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_451827", "map_id": "none", "name": "DS:FT:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_451839", "map_id": "none", "name": "DCO binds to FT", "reversible": "false", "notes": "Fat (FT) is cleaved in its extracellular domain at an unknown site with the two fragments produced remaining stably associated after processing. The casein kinase 1 epsilon orthologue, Discs overgrown (DCO) binds to the cytoplasmic part of FT.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_350966", "map_id": "none", "name": "DS:FT", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_350440", "map_id": "none", "name": "FT binds to DS in an adjacent cell", "reversible": "false", "notes": "The transmembrane non-classical cadherin Fat (FT) binds extracellularly to the transmembrane non-classical cadherin Dachsous (DS) in adjacent cells.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_351124", "map_id": "Q24292", "name": "DS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_351109", "map_id": "P33450", "name": "FT", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10431303", "map_id": "none", "name": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10431475", "map_id": "none", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10431472", "map_id": "none", "name": "OXCT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9W058", "map_id": "Q9W058", "name": "SCOT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035298", "map_id": "FBgn0035298", "name": "SCOT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449897", "map_id": "none", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449895", "map_id": "none", "name": "Active c-Src:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10449912", "map_id": "none", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432006", "map_id": "none", "name": "YWHAQ dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10449910", "map_id": "none", "name": "14-3-3-zeta:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10433182", "map_id": "none", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77284", "map_id": "CHEBI:28935", "name": "trans-Hexadec-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10433179", "map_id": "none", "name": "ACADVL dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A1ZBJ2", "map_id": "A1ZBJ2", "name": "cg7461", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034432", "map_id": "FBgn0034432", "name": "cg7461", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433188", "map_id": "none", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77302", "map_id": "CHEBI:15491", "name": "3-Oxopalmitoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77272", "map_id": "CHEBI:15532", "name": "MYS-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433186", "map_id": "none", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77300", "map_id": "CHEBI:27402", "name": "(S)-3-Hydroxyhexadecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433184", "map_id": "none", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10427815", "map_id": "none", "name": "CHEK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10474328", "map_id": "none", "name": "BRD7 promotes EP300-mediated acetylation of TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467732", "map_id": "none", "name": "BRD7:p-S15,S20-TP53:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VLX2", "map_id": "Q9VLX2", "name": "Dmel\\CG7154", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031947", "map_id": "FBgn0031947", "name": "Dmel\\CG7154", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474325", "map_id": "none", "name": "BRD7:Ac-K382,p-S15,S20-TP53:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10467734", "map_id": "none", "name": "BRD7 binds TP53 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467730", "map_id": "Q9VLX2", "name": "Dmel\\CG7154", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10486189", "map_id": "none", "name": "MTA2-NuRD complex deacetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486149", "map_id": "none", "name": "BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10486151", "map_id": "none", "name": "KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_5566518", "map_id": "CHEBI:30089", "name": "acetate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10486186", "map_id": "none", "name": "MTA2-NuRD complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10491585", "map_id": "none", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491571", "map_id": "none", "name": "PIP4K2B dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10491582", "map_id": "none", "name": "p-S326-PIP4K2B dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10450891", "map_id": "O62602", "name": "phospho-lic", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10487140", "map_id": "none", "name": "ING2-bound EP300 acetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10487130", "map_id": "none", "name": "ING2:EP300:p-S15,S20-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VEF5", "map_id": "Q9VEF5", "name": "Dmel\\CG7379", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038546", "map_id": "FBgn0038546", "name": "Dmel\\CG7379", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487137", "map_id": "none", "name": "ING2:EP300:Ac-K382,p-S15,S20-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10491589", "map_id": "none", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10455258", "map_id": "P54353", "name": "dod", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0015379", "map_id": "FBgn0015379", "name": "dod", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10491587", "map_id": "none", "name": "p-S326-PIP4K2B dimers:PIN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P54353", "map_id": "P54353", "name": "dod", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486887", "map_id": "none", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469624", "map_id": "Q9VEF5", "name": "Dmel\\CG7379", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10486885", "map_id": "none", "name": "ING2:PI5P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13231", "compartment_display": "nuclear envelope", "complex": "true" }, { "id": "reaction_10487132", "map_id": "none", "name": "ING2 recruits EP300 to TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10454653", "map_id": "none", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446818", "map_id": "A8DYW8", "name": "RapGAP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0264895", "map_id": "FBgn0264895", "name": "phospho-RapGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10454640", "map_id": "A8DYW8", "name": "phospho-RapGAP1", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10454650", "map_id": "none", "name": "PKA catalytic subunits, PKG type I", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10446840", "map_id": "none", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446032", "map_id": "none", "name": "RAPGEF3:cAMP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "A1Z6P8", "map_id": "A1Z6P8", "name": "Epac", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446823", "map_id": "none", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446816", "map_id": "A8DYW8", "name": "RapGAP1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10446821", "map_id": "none", "name": "RAP1GAP2:14-3-3beta, zeta", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A8DYW8", "map_id": "A8DYW8", "name": "phospho-RapGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454642", "map_id": "none", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10446848", "map_id": "none", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446846", "map_id": "none", "name": "Rap1-GTP:Raf1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10433100", "map_id": "none", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433097", "map_id": "none", "name": "Pol II transcription complex containing extruded transcript to +30", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434824", "map_id": "none", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10472491", "map_id": "none", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10472480", "map_id": "none", "name": "55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VLJ9", "map_id": "Q9VLJ9", "name": "mRpL51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032053", "map_id": "FBgn0032053", "name": "mRpL51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMY1", "map_id": "Q9VMY1", "name": "mRpL24", "type": "complex_component", "sub_type": "protein_component", 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"id": "FBgn0031357", "map_id": "FBgn0031357", "name": "mRpL48", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVX4", "map_id": "Q9VVX4", "name": "mRpL21", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036853", "map_id": "FBgn0036853", "name": "mRpL21", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYI3", "map_id": "Q9VYI3", "name": "mRpL49", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030433", "map_id": "FBgn0030433", "name": "mRpL49", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VY48", "map_id": "Q9VY48", "name": 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"compartment_display": "none" }, { "id": "FBgn0039159", "map_id": "FBgn0039159", "name": "mRpS24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKX4", "map_id": "Q9VKX4", "name": "mRpS7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032236", "map_id": "FBgn0032236", "name": "mRpS7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IP62", "map_id": "Q8IP62", "name": "mRpS23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260407", "map_id": "FBgn0260407", "name": "mRpS23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZD5", "map_id": "Q9VZD5", "name": "mRpS6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035534", "map_id": "FBgn0035534", "name": "mRpS6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAY9", "map_id": "Q9VAY9", "name": "mRpS22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039555", "map_id": "FBgn0039555", "name": "mRpS22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472487", "map_id": "none", "name": "GFM1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VM33", "map_id": "Q9VM33", "name": "mEFG1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263133", "map_id": "FBgn0263133", "name": "mEFG1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472489", "map_id": "none", "name": "55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10472506", "map_id": "none", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10472502", "map_id": "none", "name": "MTRF1L, ICT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VK20", "map_id": "Q9VK20", "name": "mRF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032486", "map_id": "FBgn0032486", "name": "mRF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472493", "map_id": "none", "name": "55S ribosome:mRNA:peptidyl-tRNA at P-site", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10472504", "map_id": "none", "name": "55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10472535", "map_id": "none", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10472524", "map_id": "Q9VSW4", "name": "mRRF1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0035980", "map_id": "FBgn0035980", "name": "mRRF1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472510", "map_id": "none", "name": "55S ribosome:mRNA:tRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10472533", "map_id": "none", "name": "55S ribosome:mRNA:tRNA:MRRF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VSW4", "map_id": "Q9VSW4", "name": "mRRF1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472531", "map_id": "none", "name": "Hydrolysis of GTP and dissociation of 28S and 39S subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10472526", "map_id": "none", "name": "55S ribosome:MRRF:GFM2:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VCX4", "map_id": "Q9VCX4", "name": "mRRF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051159", "map_id": "FBgn0051159", "name": "mRRF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472528", "map_id": "none", "name": "GFM2:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10472216", "map_id": "none", "name": "28S ribosomal subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10472474", "map_id": "none", "name": "39S ribosomal subunit", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10472512", "map_id": "none", "name": "55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5419287", "map_id": "none", "name": "polypeptide", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10497334", "map_id": "none", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10497318", "map_id": "none", "name": "PEX3:PEX19:class I PMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q9VUL8", "map_id": "Q9VUL8", "name": "Pex3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JZE1", "map_id": "Q7JZE1", "name": "Pex11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034058", "map_id": "FBgn0034058", "name": "Pex11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7YZT2", "map_id": "B7YZT2", "name": "Fis1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039969", "map_id": "FBgn0039969", "name": "Fis1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQI6", "map_id": "Q9VQI6", "name": "DmCG8814", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031478", "map_id": "FBgn0031478", "name": "DmCG8814", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRJ3", "map_id": "Q9VRJ3", "name": "Gdap1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035587", "map_id": "FBgn0035587", "name": "Gdap1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPB9", "map_id": "Q9VPB9", "name": "Pex16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037019", "map_id": "FBgn0037019", "name": "Pex16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0S0WGR0", "map_id": "A0A0S0WGR0", "name": "anon-WO0118547.268", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035252", "map_id": "FBgn0035252", "name": "anon-WO0118547.268", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZD9", "map_id": "Q9VZD9", "name": "PMP34", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052250", "map_id": "FBgn0052250", "name": "PMP34", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL02", "map_id": "Q9VL02", "name": "nmd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005322", "map_id": "FBgn0005322", "name": "nmd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497332", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10497336", "map_id": "none", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10497316", "map_id": "none", "name": "PEX19:class I PMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497338", "map_id": "none", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497314", "map_id": "none", "name": "Class I Peroxisomal Membrane Proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497233", "map_id": "none", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497208", "map_id": "none", "name": "Ub:PEX5L", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10497210", "map_id": "none", "name": "USP9X:Ub:PEX5L", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497248", "map_id": "none", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10497187", "map_id": "Q9W106", "name": "Dmel\\CG3589", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "FBgn0035065", "map_id": "FBgn0035065", "name": "Dmel\\CG3589", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497245", "map_id": "Q9W106", "name": "Dmel\\CG3589", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10497243", "map_id": "Q9W106", "name": "Dmel\\CG3589", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10497250", "map_id": "none", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10497197", "map_id": "none", "name": "PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q9VSN7", "map_id": "Q9VSN7", "name": "Pex7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035922", "map_id": "FBgn0035922", "name": "Pex7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497199", "map_id": "none", "name": "PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10497204", "map_id": "none", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10497201", "map_id": "none", "name": "PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10497191", "map_id": "none", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10497173", "map_id": "none", "name": "PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q7JZB1", "map_id": "Q7JZB1", "name": "Dmel\\CG12338", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033543", "map_id": "FBgn0033543", "name": "Dmel\\CG12338", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM80", "map_id": "Q9VM80", "name": "Dmel\\CG11236", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031860", "map_id": "FBgn0031860", "name": "Dmel\\CG11236", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V492", "map_id": "Q9V492", "name": "MPV17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039930", "map_id": "FBgn0039930", "name": "MPV17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8D3", "map_id": "A1Z8D3", "name": "Dmel\\CG18003", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0061356", "map_id": "FBgn0061356", "name": "Dmel\\CG18003", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W106", "map_id": "Q9W106", "name": "Dmel\\CG3589", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7Z028", "map_id": "B7Z028", "name": "LCAD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031813", "map_id": "FBgn0031813", "name": "LCAD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W5W8", "map_id": "Q9W5W8", "name": "Dmel\\CG9577", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031092", "map_id": "FBgn0031092", "name": "Dmel\\CG9577", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3Z3", "map_id": "Q9W3Z3", "name": "Spat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014031", "map_id": "FBgn0014031", "name": "Spat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K3B7", "map_id": "Q7K3B7", "name": "Hacl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034488", "map_id": "FBgn0034488", "name": "Hacl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIK0", "map_id": "Q9VIK0", "name": "Amacr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEM4", "map_id": "Q9VEM4", "name": "Dmel\\CG5265", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038486", "map_id": "FBgn0038486", "name": "Dmel\\CG5265", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VB02", "map_id": "Q9VB02", "name": "CROT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039543", "map_id": "FBgn0039543", "name": "CROT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22817", "map_id": "P22817", "name": "Ide", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001247", "map_id": "FBgn0001247", "name": "Ide", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIV6", "map_id": "Q9VIV6", "name": "Dmel\\CG10194", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032790", "map_id": "FBgn0032790", "name": "Dmel\\CG10194", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497189", "map_id": "none", "name": "Cargo proteins containing PTS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10497193", "map_id": "none", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10497171", "map_id": "none", "name": "PEX13:PEX14:PEX2:PEX10:PEX12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "species_10497169", "map_id": "none", "name": "PEX5S,L:Cargo protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497241", "map_id": "none", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10497237", "map_id": "none", "name": "PEX5L:PEX7:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q9V778", "map_id": "Q9V778", "name": "ADPS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033983", "map_id": "FBgn0033983", "name": "ADPS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497239", "map_id": "Q9V778", "name": "ADPS", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10497213", "map_id": "none", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497167", "map_id": "O46085", "name": "Pex5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10497087", "map_id": "none", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497083", "map_id": "Q9V778", "name": "ADPS", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10497078", "map_id": "Q9VSN7", "name": "Pex7", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10497085", "map_id": "none", "name": "PEX7:Cargo proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497622", "map_id": "none", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497405", "map_id": "none", "name": "SGTA dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VJD4", "map_id": "Q9VJD4", "name": "Sgt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032640", "map_id": "FBgn0032640", "name": "Sgt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497618", "map_id": "none", "name": "Mislocalized membrane protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10497620", "map_id": "none", "name": "Mislocalized membrane protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497453", "map_id": "none", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497449", "map_id": "none", "name": "Tail-anchored proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7JZN0", "map_id": "Q7JZN0", "name": "Sec61beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010638", "map_id": "FBgn0010638", "name": "Sec61beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWE9", "map_id": "Q9VWE9", "name": "Sec61gamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031049", "map_id": "FBgn0031049", "name": "Sec61gamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SYY6", "map_id": "Q8SYY6", "name": "Dmel\\CG32276", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0047135", "map_id": "FBgn0047135", "name": "Dmel\\CG32276", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEJ4", "map_id": "Q9VEJ4", "name": "Dmel\\CG5823", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038515", "map_id": "FBgn0038515", "name": "Dmel\\CG5823", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B7Z0E5", "map_id": "B7Z0E5", "name": "mfr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266757", "map_id": "FBgn0266757", "name": "mfr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497451", "map_id": "none", "name": "Tail-anchored protein:SGTA dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495803", "map_id": "none", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10495795", "map_id": "none", "name": "Mitochondrial targeting peptides (from inner membrane proteins)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10495800", "map_id": "Q9V9E3", "name": "PITRM1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0033005", "map_id": "FBgn0033005", "name": "PITRM1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10462211", "map_id": "none", "name": "TIMM9:TIMM10 transfers proteins to TIMM22", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10462198", "map_id": "none", "name": "TIMM9:TIMM10:Protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9W2D6", "map_id": "Q9W2D6", "name": "Tim10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027360", "map_id": "FBgn0027360", "name": "Tim10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYD7", "map_id": "Q9VYD7", "name": "Tim9a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030480", "map_id": "FBgn0030480", "name": "Tim9a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10462173", "map_id": "Q8IN78", "name": "Tim22", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0051229", "map_id": "FBgn0051229", "name": "Tim22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10462205", "map_id": "Q9Y0V3", "name": "Tim9b", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0027358", "map_id": "FBgn0027358", "name": "Tim9b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10462209", "map_id": "none", "name": "TIMM9:TIMM10:TIMM10B:TIM22:Protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9Y0V3", "map_id": "Q9Y0V3", "name": "Tim9b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IN78", "map_id": "Q8IN78", "name": "Tim22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471823", "map_id": "none", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471803", "map_id": "P13060", "name": "eEF2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10471790", "map_id": "P13060", "name": "eEF2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10471820", "map_id": "none", "name": "DPH1:DPH2:DPH3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VGQ9", "map_id": "Q9VGQ9", "name": "DPH3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037883", "map_id": "FBgn0037883", "name": "DPH3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFE9", "map_id": "Q9VFE9", "name": "Dph2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038272", "map_id": "FBgn0038272", "name": "Dph2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTM2", "map_id": "Q9VTM2", "name": "Dph1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036194", "map_id": "FBgn0036194", "name": "Dph1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471787", "map_id": "none", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471779", "map_id": "P13060", "name": "eEF2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10471784", "map_id": "Q8MRI4", "name": "Dmel\\CG1578", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030336", "map_id": "FBgn0030336", "name": "Dmel\\CG1578", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471801", "map_id": "none", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471793", "map_id": "P13060", "name": "eEF2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10471798", "map_id": "Q8IN02", "name": "Dph5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0024558", "map_id": "FBgn0024558", "name": "Dph5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479423", "map_id": "none", "name": "USP8 deubiquitinates STAM2:HGS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479418", "map_id": "none", "name": "USP8:Ub-STAM2:HGS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10479420", "map_id": "none", "name": "USP8:STAM2:HGS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479326", "map_id": "none", "name": "USP13 binds SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479324", "map_id": "none", "name": "SIAH2:USP13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VZU7", "map_id": "Q9VZU7", "name": "Usp5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477596", "map_id": "none", "name": "USP3,SAGA deubiquitinate Histone H2A,H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477591", "map_id": "none", "name": "USP3,SAGA:Ub-histone H2A, Ub-histone H2B", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q27272", "map_id": "Q27272", "name": "e(y)1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000617", "map_id": "FBgn0000617", "name": "e(y)1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PHZ1", "map_id": "M9PHZ1", "name": "Ada3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030891", "map_id": "FBgn0030891", "name": "Ada3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZT7", "map_id": "Q9XZT7", "name": "Taf10b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026324", "map_id": "FBgn0026324", "name": "Taf10b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I8V0", "map_id": "Q8I8V0", "name": "Ada2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037555", "map_id": "FBgn0037555", "name": "Ada2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVR1", "map_id": "Q9VVR1", "name": "not", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013717", "map_id": "FBgn0013717", "name": "not", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477593", "map_id": "none", "name": "USP3,SAGA:Histone H2A,Histone H2B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477625", "map_id": "none", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477618", "map_id": "none", "name": "USP21:PolyUb-RIPK1, PolyUb-DDX58", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IQ27", "map_id": "Q8IQ27", "name": "Usp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031187", "map_id": "FBgn0031187", "name": "Usp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477620", "map_id": "none", "name": "USP21:RIPK1,DDX58", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10477496", "map_id": "none", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477261", "map_id": "none", "name": "USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477267", "map_id": "none", "name": "USP7:TP53,MDM2,MDM4,FOXO4,PTEN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477493", "map_id": "none", "name": "PolyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477112", "map_id": "none", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477108", "map_id": "Q9VKZ8", "name": "Usp14", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475480", "map_id": "none", "name": "ADRM1:26S proteasome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K2G1", "map_id": "Q7K2G1", "name": "Rpn13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033886", "map_id": "FBgn0033886", "name": "Rpn13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477110", "map_id": "none", "name": "ADRM1:26S proteasome:USP14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479189", "map_id": "none", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479180", "map_id": "none", "name": "USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VRP5", "map_id": "Q9VRP5", "name": "scny", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9U1H8", "map_id": "Q9U1H8", "name": "Sras", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479186", "map_id": "none", "name": "USP17L1,USP17L2:RCE1, CDC25A, DDX58, IFIH1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479220", "map_id": "none", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479215", "map_id": "none", "name": "CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IPC5", "map_id": "Q8IPC5", "name": "CYLD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032210", "map_id": "FBgn0032210", "name": "CYLD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479217", "map_id": "none", "name": "TRAF2,TRAF6,IKBKG,RIPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479281", "map_id": "none", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479276", "map_id": "none", "name": "USP13:K63polyUb-BECN1,K63polyUb-USP10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VCE1", "map_id": "Q9VCE1", "name": "phospho-Atg6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264325", "map_id": "FBgn0264325", "name": "phospho-Atg6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479278", "map_id": "none", "name": "USP13:BECN1,USP10", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10477646", "map_id": "none", "name": "USP8 deubiquitinates RNF128", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477637", "map_id": "none", "name": "USP8:K48polyUb-RNF128:OTUB1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10477643", "map_id": "none", "name": "USP8:RNF128:OTUB1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479438", "map_id": "none", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479431", "map_id": "none", "name": "USP17:K63polyUb-SUDS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VWG2", "map_id": "Q9VWG2", "name": "SDS3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031036", "map_id": "FBgn0031036", "name": "SDS3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477395", "map_id": "none", "name": "K63polyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10479435", "map_id": "none", "name": "USP17:SUDS3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477515", "map_id": "none", "name": "USP10,USP24,USP42 deubiquitinate TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477510", "map_id": "none", "name": "USP10,USP24,USP42:PolyUb-TP53", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7JQI1", "map_id": "Q7JQI1", "name": "DUBAI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033738", "map_id": "FBgn0033738", "name": "DUBAI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477512", "map_id": "none", "name": "USP10,USP24,USP42:TP53", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479211", "map_id": "none", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479206", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:PolyUb-AR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VBC4", "map_id": "Q9VBC4", "name": "Dmel\\CG6420", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039451", "map_id": "FBgn0039451", "name": "Dmel\\CG6420", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCT9", "map_id": "Q9VCT9", "name": "Usp12-46", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039025", "map_id": "FBgn0039025", "name": "Usp12-46", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479208", "map_id": "none", "name": "USP12:WDR48:WDR20,USP26:AR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477608", "map_id": "none", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477603", "map_id": "none", "name": "USP5:PolyUb", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10477605", "map_id": "none", "name": "USP5:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479269", "map_id": "none", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479262", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:PolyUb-CCNA1,PolyUb-CCNA2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P14785", "map_id": "P14785", "name": "CycA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000404", "map_id": "FBgn0000404", "name": "CycA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZP3", "map_id": "Q9VZP3", "name": "CycJ", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010317", "map_id": "FBgn0010317", "name": "CycJ", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479266", "map_id": "none", "name": "USP37:RUVLB1:PSMC5:CCNA1,CCNA2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479459", "map_id": "none", "name": "USP21 deubiquitinates GATA3,IL33", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10479454", "map_id": "none", "name": "USP21:PolyUb-GATA3,PolyUb-IL33", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10479456", "map_id": "none", "name": "USP21:GATA3,IL33", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10479557", "map_id": "none", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457720", "map_id": "none", "name": "p-Y705-STAT3 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479555", "map_id": "none", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10454317", "map_id": "none", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10454314", "map_id": "none", "name": "ALDH5A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VBP6", "map_id": "Q9VBP6", "name": "Ssadh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039349", "map_id": "FBgn0039349", "name": "Ssadh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454932", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_916850", "map_id": "CHEBI:59888", "name": "GABA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10454929", "map_id": "none", "name": "PXLP-K357-ABAT dimer:2Fe-2S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VW68", "map_id": "Q9VW68", "name": "Gabat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036927", "map_id": "FBgn0036927", "name": "Gabat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457567", "map_id": "none", "name": "JMJD1C demethylates H3K9 mono- and di-methylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10457547", "map_id": "none", "name": "Histone H3 mono or di-methylated at K9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10457559", "map_id": "none", "name": "Histone H3 mono- or unmethylated at K9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10457564", "map_id": "Q9VHC5", "name": "JHDM2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0037703", "map_id": "FBgn0037703", "name": "JHDM2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457532", "map_id": "none", "name": "ZFPM proteins bind GATA proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10457477", "map_id": "Q9VPQ6", "name": "ush", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10457528", "map_id": "none", "name": "GATA proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P52168", "map_id": "P52168", "name": "pnr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003117", "map_id": "FBgn0003117", "name": "pnr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VF00", "map_id": "Q9VF00", "name": "GATAe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038391", "map_id": "FBgn0038391", "name": "GATAe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457530", "map_id": "none", "name": "ZFPM proteins:GATA proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10457401", "map_id": "none", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457397", "map_id": "none", "name": "Dual-specific AKAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KVW1", "map_id": "Q7KVW1", "name": "spoon", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263987", "map_id": "FBgn0263987", "name": "spoon", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3I3", "map_id": "Q9V3I3", "name": "pkaap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040079", "map_id": "FBgn0040079", "name": "pkaap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457399", "map_id": "none", "name": "Dual-specific AKAPs:PKA tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457385", "map_id": "none", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10457381", "map_id": "none", "name": "Mitofusins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10457383", "map_id": "none", "name": "Mitofusin complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "reaction_10457432", "map_id": "none", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10457428", "map_id": "none", "name": "Histone H3 methylated at lysine-9", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10457406", "map_id": "Q9VCU6", "name": "HP1c", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0039019", "map_id": "FBgn0039019", "name": "HP1c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457430", "map_id": "none", "name": "HP1alpha:Histone H3 methylated at K9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VCU6", "map_id": "Q9VCU6", "name": "HP1c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457637", "map_id": "none", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457633", "map_id": "none", "name": "RAC1, CDC42", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10457631", "map_id": "none", "name": "DOCK-GEFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "M9PCG3", "map_id": "M9PCG3", "name": "Ziz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260486", "map_id": "FBgn0260486", "name": "Ziz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPI9", "map_id": "Q9VPI9", "name": "Zir", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457635", "map_id": "none", "name": "DOCK-GEFs:RAC1, CDC42", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457604", "map_id": "none", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10457600", "map_id": "Q9VLS5", "name": "Rbsn-5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "FBgn0261064", "map_id": "FBgn0261064", "name": "Rbsn-5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457591", "map_id": "Q8T8W3", "name": "Past1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "FBgn0016693", "map_id": "FBgn0016693", "name": "Past1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457602", "map_id": "none", "name": "C-terminal EH domain containing proteins:Rabenosyn-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q8T8W3", "map_id": "Q8T8W3", "name": "Past1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLS5", "map_id": "Q9VLS5", "name": "Rbsn-5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457586", "map_id": "none", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10457583", "map_id": "Q9VGU6", "name": "Ak3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10454176", "map_id": "none", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454167", "map_id": "Q9W2N0", "name": "cpa", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0034577", "map_id": "FBgn0034577", "name": "cpa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10454172", "map_id": "P48603", "name": "cpb", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10454174", "map_id": "none", "name": "F-actin capping protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W2N0", "map_id": "Q9W2N0", "name": "cpa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457472", "map_id": "none", "name": "REST recruits the BHC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10457446", "map_id": "none", "name": "REST:REST DNA binding sites", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q59E36", "map_id": "Q59E36", "name": "CoRest", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261573", "map_id": "FBgn0261573", "name": "CoRest", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IPD6", "map_id": "Q8IPD6", "name": "Desr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051875", "map_id": "FBgn0051875", "name": "Desr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457468", "map_id": "none", "name": "BHC complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W2K8", "map_id": "Q9W2K8", "name": "Hmg-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026582", "map_id": "FBgn0026582", "name": "Hmg-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VW97", "map_id": "Q9VW97", "name": "Su(var)3-3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260397", "map_id": "FBgn0260397", "name": "Su(var)3-3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457470", "map_id": "none", "name": "BHC complex:REST:REST DNA binding sites", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10457648", "map_id": "none", "name": "Rabenosyn-5 connects Rab5 to VPS-45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10457639", "map_id": "Q9V3I2", "name": "Rab5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "species_10457644", "map_id": "Q9VHB5", "name": "Vps45", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "species_10457646", "map_id": "none", "name": "Rabenosyn-5:VPS-45", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10480078", "map_id": "none", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_1222719", "map_id": "CHEBI:16240", "name": "H2O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_6788973", "map_id": "CHEBI:17996", "name": "Cl-", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_1222475", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_6789150", "map_id": "CHEBI:24757", "name": "HOCl", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_10480037", "map_id": "none", "name": "MPO:ferriheme", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "CHEBI:55376", "map_id": "CHEBI:55376", "name": "CHEBI:55376", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZZ4", "map_id": "Q9VZZ4", "name": "Pxn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011828", "map_id": "FBgn0011828", "name": "Pxn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10480042", "map_id": "none", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_10480039", "map_id": "none", "name": "MPO:ferriheme:bacterial cell surface", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "reaction_10489081", "map_id": "none", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8855492", "map_id": "CHEBI:18022", "name": "SCN(-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_8855489", "map_id": "CHEBI:133907", "name": "OSCN-", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10489078", "map_id": "none", "name": "LPO:ferriheme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10491978", "map_id": "none", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_6789221", "map_id": "CHEBI:16301", "name": "nitrite", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "species_8933637", "map_id": "CHEBI:33101", "name": "NO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "false" }, { "id": "reaction_10480080", "map_id": "none", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "reaction_209075", "map_id": "none", "name": "Destabilisation and degradation of AXN in the 'destruction complex'", "reversible": "false", "notes": "Axin (AXN) is now destabilised and is degraded by an unknown mechanism, possibly by a similar ubiquitin-mediated proteolysis responsible for cytoplasmic Armadillo (ARM) degradation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_206993", "map_id": "none", "name": "WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_206837", "map_id": "none", "name": "WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209120", "map_id": "none", "name": "Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR", "reversible": "false", "notes": "Phosphorylated Arrow (ARR) is recognised by Axin (AXN) which binds to it along with the rest of the 'destruction complex'. Dishevelled (DSH) is recruited to the cytoplasmic part of Frizzled (FZ/FZ2) and additionally forms an interaction with AXN. There is conjecture whether DSH first binds to AXN, helping to recruit it to the membrane, while the 'destruction complex' is free in the cytoplasm.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_205749", "map_id": "P51140", "name": "DSH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206952", "map_id": "none", "name": "WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209081", "map_id": "none", "name": "Disassembly of the destabilised 'destruction complex'", "reversible": "false", "notes": "The destabilised 'destruction complex' disassembles into the cytoplasm. The cytoplasmic concentration of Axin (AXN) has now decreased.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_209112", "map_id": "none", "name": "Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM", "reversible": "false", "notes": "The binding of Dishevelled (DSH) to Axin (AXN) in the 'destruction complex' appears to inhibit the kinase Shaggy (SGG). As this component appears to be the main instigator in keeping the 'destruction complex' phosphorylated, it's inactivation means the protein phosphatase orthologue, PP2A, can dephosphorylate members of the 'destruction complex'. This results in a decreased binding affinity for Armadillo (ARM) by AXN and APC (APC/APC2). The now unphosphorylated ARM disassociates from the 'destruction complex' into the cytoplasm.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206612", "map_id": "none", "name": "PP2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209297", "map_id": "none", "name": "PYGO binds to the LGS:ARM complex", "reversible": "false", "notes": "The now nuclear Legless:Armadillo (LGS:ARM) complex binds to the nuclear anchor Pygopus (PYGO).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_206851", "map_id": "none", "name": "LGS:ARM:PYGO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_209181", "map_id": "none", "name": "ARM displaces GRO and binds to PAN which activates transcription", "reversible": "false", "notes": "Armadillo (ARM) in its complex binds to Pangolin (PAN) and transcription is now activated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_206729", "map_id": "none", "name": "PAN:LGS:ARM:PYGO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10428700", "map_id": "none", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30337", "map_id": "CHEBI:16169", "name": "HGTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31135", "map_id": "CHEBI:17105", "name": "4MAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428697", "map_id": "none", "name": "HGD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VKJ0", "map_id": "Q9VKJ0", "name": "hgo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040211", "map_id": "FBgn0040211", "name": "hgo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428678", "map_id": "none", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31365", "map_id": "CHEBI:15999", "name": "HPPYRA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428675", "map_id": "none", "name": "TAT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VY42", "map_id": "Q9VY42", "name": "Dmel\\CG1461", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030558", "map_id": "FBgn0030558", "name": "Dmel\\CG1461", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428710", "map_id": "none", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31175", "map_id": "CHEBI:18034", "name": "4FAA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428707", "map_id": "none", "name": "GSTZ1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10428690", "map_id": "none", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428687", "map_id": "none", "name": "HPD:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VPF3", "map_id": "Q9VPF3", "name": "Hpd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036992", "map_id": "FBgn0036992", "name": "Hpd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428720", "map_id": "none", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428717", "map_id": "none", "name": "FAH dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VZI8", "map_id": "Q9VZI8", "name": "Faa", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016013", "map_id": "FBgn0016013", "name": "Faa", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479117", "map_id": "none", "name": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5696361", "map_id": "CHEBI:2877", "name": "aspartame", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5359061", "map_id": "CHEBI:17790", "name": "MeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479114", "map_id": "none", "name": "ASRGL1 heterodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VXT7", "map_id": "Q9VXT7", "name": "ASRGL1(1-167)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030653", "map_id": "FBgn0030653", "name": "ASRGL1(1-167)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454396", "map_id": "none", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893599", "map_id": "CHEBI:29750", "name": "3IN-PYRA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10428667", "map_id": "none", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_71112", "map_id": "CHEBI:15374", "name": "4aOH-BH4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_71129", "map_id": "CHEBI:20680", "name": "qDHB", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428664", "map_id": "none", "name": "PCBD1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O76454", "map_id": "O76454", "name": "Pcd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024841", "map_id": "FBgn0024841", "name": "Pcd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428647", "map_id": "none", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428644", "map_id": "none", "name": "PAH:Fe2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P17276", "map_id": "P17276", "name": "Hn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001208", "map_id": "FBgn0001208", "name": "Hn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428657", "map_id": "none", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428654", "map_id": "none", "name": "QDPR dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSU6", "map_id": "Q9VSU6", "name": "Dhpr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035964", "map_id": "FBgn0035964", "name": "Dhpr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10426910", "map_id": "none", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426899", "map_id": "none", "name": "Orc4:Orc5:Orc3:Orc2:origin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10426906", "map_id": "O16810", "name": "Orc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10426908", "map_id": "none", "name": "Orc1:Orc4:Orc5:Orc3:Orc2:origin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10426892", "map_id": "none", "name": "Orc5 associates with Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426881", "map_id": "none", "name": "Orc3:Orc2:origin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10426888", "map_id": "Q24169", "name": "Orc5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10426890", "map_id": "none", "name": "Orc5:Orc3:Orc2:origin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10426919", "map_id": "none", "name": "Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426915", "map_id": "Q9Y1B2", "name": "Orc6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10426917", "map_id": "none", "name": "ORC complex bound to origin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10426901", "map_id": "none", "name": "Orc4 associates with Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426897", "map_id": "Q9W102", "name": "Orc4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10426883", "map_id": "none", "name": "Orc3 associates with Orc2 constitutively bound at origins of replication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426872", "map_id": "Q7K2L1", "name": "Orc3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10426879", "map_id": "none", "name": "Orc2:origin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432475", "map_id": "none", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432463", "map_id": "none", "name": "Pol II initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VIP1", "map_id": "Q9VIP1", "name": "Taf13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032847", "map_id": "FBgn0032847", "name": "Taf13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24325", "map_id": "Q24325", "name": "Taf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011836", "map_id": "FBgn0011836", "name": "Taf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGJ3", "map_id": "Q9VGJ3", "name": "Dmel\\CG14718", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037939", "map_id": "FBgn0037939", "name": "Dmel\\CG14718", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P47825", "map_id": "P47825", "name": "Taf4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010280", "map_id": "FBgn0010280", "name": "Taf4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJP5", "map_id": "Q9VJP5", "name": "nht", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041103", "map_id": "FBgn0041103", "name": "nht", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49847", "map_id": "P49847", "name": "Taf6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010417", "map_id": "FBgn0010417", "name": "Taf6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHY5", "map_id": "Q9VHY5", "name": "Taf7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024909", "map_id": "FBgn0024909", "name": "Taf7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49846", "map_id": "P49846", "name": "Taf5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010356", "map_id": "FBgn0010356", "name": "Taf5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VT91", "map_id": "Q9VT91", "name": "can", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011569", "map_id": "FBgn0011569", "name": "can", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCN9", "map_id": "Q9VCN9", "name": "wda", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039067", "map_id": "FBgn0039067", "name": "wda", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49906", "map_id": "P49906", "name": "Taf11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011291", "map_id": "FBgn0011291", "name": "Taf11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P51123", "map_id": "P51123", "name": "Taf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010355", "map_id": "FBgn0010355", "name": "Taf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49905", "map_id": "P49905", "name": "Taf12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011290", "map_id": "FBgn0011290", "name": "Taf12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4D4", "map_id": "Q9V4D4", "name": "Taf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026262", "map_id": "FBgn0026262", "name": "Taf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P29052", "map_id": "P29052", "name": "TfIIB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004915", "map_id": "FBgn0004915", "name": "TfIIB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96881", "map_id": "O96881", "name": "TfIIEbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015829", "map_id": "FBgn0015829", "name": "TfIIEbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96880", "map_id": "O96880", "name": "TfIIEalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015828", "map_id": "FBgn0015828", "name": "TfIIEalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432471", "map_id": "none", "name": "Pol II Initiation complex with phosphodiester-PPi intermediate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432473", "map_id": "none", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10431434", "map_id": "none", "name": "pol II transcription complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432465", "map_id": "none", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432459", "map_id": "none", "name": "pol II open pre-initiation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10437548", "map_id": "none", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_73663", "map_id": "CHEBI:46245", "name": "CoQ", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10437537", "map_id": "none", "name": "ETF:FADH2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q0KHZ6", "map_id": "Q0KHZ6", "name": "ETFB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039697", "map_id": "FBgn0039697", "name": "ETFB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KN94", "map_id": "Q7KN94", "name": "wal", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010516", "map_id": "FBgn0010516", "name": "wal", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_76633", "map_id": "CHEBI:17976", "name": "QH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10437535", "map_id": "none", "name": "ETF:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10437545", "map_id": "Q7JWF1", "name": "Etf-QO", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0286783", "map_id": "FBgn0286783", "name": "Etf-QO", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436779", "map_id": "none", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10436776", "map_id": "none", "name": "Ubiquinol-cytochrome c reductase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VRL0", "map_id": "Q9VRL0", "name": "Cyt-c1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035600", "map_id": "FBgn0035600", "name": "Cyt-c1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFF0", "map_id": "Q9VFF0", "name": "UQCR-C1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038271", "map_id": "FBgn0038271", "name": "UQCR-C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXI6", "map_id": "Q9VXI6", "name": "UQCR-14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030733", "map_id": "FBgn0030733", "name": "UQCR-14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQ29", "map_id": "Q9VQ29", "name": "RFeSP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0021906", "map_id": "FBgn0021906", "name": "RFeSP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVH5", "map_id": "Q9VVH5", "name": "UQCR-Q", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036728", "map_id": "FBgn0036728", "name": "UQCR-Q", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8Y535", "map_id": "A8Y535", "name": "UQCR-11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260008", "map_id": "FBgn0260008", "name": "UQCR-11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18935", "map_id": "P18935", "name": "mt:Cyt-b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013678", "map_id": "FBgn0013678", "name": "mt:Cyt-b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XY35", "map_id": "Q9XY35", "name": "ox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011227", "map_id": "FBgn0011227", "name": "ox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VV75", "map_id": "Q9VV75", "name": "UQCR-C2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250814", "map_id": "FBgn0250814", "name": "UQCR-C2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10437540", "map_id": "none", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10436576", "map_id": "none", "name": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10436572", "map_id": "Q8MLL3", "name": "Coq10", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0033086", "map_id": "FBgn0033086", "name": "Coq10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440271", "map_id": "none", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176626", "map_id": "CHEBI:28689", "name": "DHEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440269", "map_id": "none", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440264", "map_id": "Q9W3N1", "name": "spidey", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10498692", "map_id": "none", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10469802", "map_id": "Q9VLP9", "name": "SRD5A3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0032014", "map_id": "FBgn0032014", "name": "SRD5A3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10443612", "map_id": "none", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10443603", "map_id": "Q9V8K2", "name": "Sec6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "false" }, { "id": "species_10443588", "map_id": "Q9VDE6", "name": "Sec15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10443573", "map_id": "Q9VNH6", "name": "Sec8", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10443608", "map_id": "Q9VSJ8", "name": "Exo70", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10443593", "map_id": "Q7KRZ3", "name": "Exo84", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10443578", "map_id": "Q9VQQ9", "name": "Sec5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10443598", "map_id": "Q9VVG4", "name": "Sec3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10443583", "map_id": "Q9XTM1", "name": "Sec10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10443610", "map_id": "none", "name": "Exocyst Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10490116", "map_id": "none", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8868399", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8868400", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10490113", "map_id": "A1Z814", "name": "Dmel\\CG1513", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0033463", "map_id": "FBgn0033463", "name": "Dmel\\CG1513", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490199", "map_id": "none", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8868393", "map_id": "CHEBI:42977", "name": "25OH-CHOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10440382", "map_id": "none", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193762", "map_id": "CHEBI:63824", "name": "TetraHCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193741", "map_id": "CHEBI:27458", "name": "25(R) TetraHCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440366", "map_id": "none", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193778", "map_id": "CHEBI:48736", "name": "3,7,24THCA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_193739", "map_id": "CHEBI:27403", "name": "3,7,24THCA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440380", "map_id": "none", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193793", "map_id": "CHEBI:27458", "name": "25(R) TetraHCA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10440378", "map_id": "none", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193760", "map_id": "CHEBI:63829", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_213285", "map_id": "CHEBI:63831", "name": "5beta-cholestan-3alpha,7alpha,24(S)-triol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440376", "map_id": "none", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193745", "map_id": "CHEBI:63839", "name": "4CHOL7a,12a,24(S)TONE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_193707", "map_id": "CHEBI:63830", "name": "5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440374", "map_id": "none", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193724", "map_id": "CHEBI:63838", "name": "4CHOL7a,24(S)DONE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10440372", "map_id": "none", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10440386", "map_id": "none", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_192189", "map_id": "CHEBI:37640", "name": "CHOL7a,24(S)DIOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10440370", "map_id": "none", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10440384", "map_id": "none", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193728", "map_id": "CHEBI:63834", "name": "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440368", "map_id": "none", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10457738", "map_id": "none", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434957", "map_id": "none", "name": "Homologues of PRKCB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10434971", "map_id": "none", "name": "Activated PKC beta", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10457781", "map_id": "none", "name": "NF-kappaB translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457765", "map_id": "none", "name": "NF-kappaB p50,p65,c-Rel dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10457779", "map_id": "none", "name": "NF-kappaB p50,p65,c-Rel dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10457811", "map_id": "none", "name": "Ubiquitinated IkB is degraded", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457809", "map_id": "none", "name": "NF-kappaB p50,p65,c-Rel:ub-p-IKB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464584", "map_id": "none", "name": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10464581", "map_id": "none", "name": "BCAP Signalosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10457751", "map_id": "none", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10457744", "map_id": "none", "name": "STIM1:Calcium", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10457746", "map_id": "none", "name": "STIM1 Dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10464790", "map_id": "none", "name": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10464787", "map_id": "none", "name": "CD19 Signalosome", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10464848", "map_id": "none", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10464844", "map_id": "none", "name": "Homologues of TRPC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458693", "map_id": "none", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458690", "map_id": "none", "name": "Potassium transport channels (Kir 1.1 and Kir 4.1/5.1)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10458898", "map_id": "none", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10458895", "map_id": "none", "name": "TALK 1and 2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q94526", "map_id": "Q94526", "name": "Ork1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017561", "map_id": "FBgn0017561", "name": "Ork1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10456991", "map_id": "none", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_983034", "map_id": "CHEBI:25676", "name": "oligopeptide fragment", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10456988", "map_id": "none", "name": "TAP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VRW2", "map_id": "Q9VRW2", "name": "Dmel\\CG10226", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035695", "map_id": "FBgn0035695", "name": "Dmel\\CG10226", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q00748", "map_id": "Q00748", "name": "Mdr65", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004513", "map_id": "FBgn0004513", "name": "Mdr65", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q00449", "map_id": "Q00449", "name": "Mdr49", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004512", "map_id": "FBgn0004512", "name": "Mdr49", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457141", "map_id": "none", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_8943716", "map_id": "CHEBI:59869", "name": "L-amino acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_983033", "map_id": "CHEBI:25676", "name": "Antigen peptide", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10457138", "map_id": "none", "name": "ERAP1/2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10433208", "map_id": "none", "name": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77326", "map_id": "CHEBI:27540", "name": "HX-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77324", "map_id": "CHEBI:28706", "name": "trans-Hex-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433206", "map_id": "none", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77322", "map_id": "CHEBI:28276", "name": "(S)-Hydroxyhexanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433204", "map_id": "none", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77320", "map_id": "CHEBI:27648", "name": "3-Oxohexanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433212", "map_id": "none", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77332", "map_id": "CHEBI:27537", "name": "trans-Oct-2-enoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77330", "map_id": "CHEBI:28632", "name": "(S)-Hydroxyoctanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433210", "map_id": "none", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77328", "map_id": "CHEBI:28264", "name": "3-Oxooctanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433222", "map_id": "none", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10433166", "map_id": "none", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77269", "map_id": "CHEBI:28726", "name": "3-Oxotetradecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_77261", "map_id": "CHEBI:15521", "name": "LAU-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433172", "map_id": "none", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77276", "map_id": "CHEBI:27466", "name": "(S)-3-Hydroxytetradecanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10433169", "map_id": "none", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_77273", "map_id": "CHEBI:27721", "name": "trans-Tetradec-2-enoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_210662", "map_id": "none", "name": "Phosphorylated HOP is dephosphorylated by PTP61F isoform 1", "reversible": "false", "notes": "The Janus tyrosine kinase, Hopscotch (HOP) is dephosphorylated in the cytosol by the protein tyrosine phosphatase, PTP61F isoform 1.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206905", "map_id": "none", "name": "Phospho HOP:DOME:UPD:DOME:Phospho HOP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q59E38", "map_id": "Q59E38", "name": "UPD3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "UPD3", "map_id": "UPD3", "name": "UPD3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWX2", "map_id": "Q9VWX2", "name": "UPD2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "UPD2", "map_id": "UPD2", "name": "UPD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O96525", "map_id": "O96525", "name": "OS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "OS", "map_id": "OS", "name": "OS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWE0", "map_id": "Q9VWE0", "name": "dome", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "dome", "map_id": "dome", "name": "dome", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_206753", "map_id": "none", "name": "HOP:DOME:UPD:DOME:HOP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_210628", "map_id": "Q9W0G1-1", "name": "PTP61F isoform 1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_210646", "map_id": "none", "name": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1", "reversible": "false", "notes": "In the cytosol, phosphorylated STAT92E dimer is dephosphorylated on Tyr711 by the protein tyrosine phosphatase, PTP61F isoform 1.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_207008", "map_id": "none", "name": "Phospho STAT92E dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_205965", "map_id": "Q24151", "name": "STAT92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_210694", "map_id": "none", "name": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2", "reversible": "false", "notes": "An alternative spliced form of the protein tyrosine phosphatase, PTP61FC (PTP61F isoform 2) is active in the nucleus and dephosphorylates the phosphorylated STAT92E dimer on Tyr711 resulting in its dissociation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_207031", "map_id": "none", "name": "Phospho STAT92E dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_206244", "map_id": "Q24151", "name": "STAT92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_210622", "map_id": "Q9W0G1-2", "name": "PTP61F isoform 2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_210687", "map_id": "none", "name": "STAT92E transports from the nucleus to the cytosol", "reversible": "false", "notes": "Unphosphorylated STAT92E translocates from the nucleus to the cytosol.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_209307", "map_id": "none", "name": "Phosphorylated STAT92E dimer activates transcription", "reversible": "false", "notes": "Once in the nucleus, the phosphorylated STAT92E dimer binds to a palindromic DNA sequence in the promoters of the pathway target genes. This now enables transcription to be activated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_209255", "map_id": "none", "name": "UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP", "reversible": "false", "notes": "The UPD (OS, UPD2, UPD3) family of ligands bind to the DOME:HOP dimer complex. Ligand binding suggests an induced conformational change in the DOME receptor that brings the HOP proteins, bound to the intracellular domains, closer together. The HOP tyrosine kinase is now activated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_206971", "map_id": "none", "name": "HOP:DOME:DOME:HOP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_206555", "map_id": "none", "name": "UPD", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_209336", "map_id": "none", "name": "Activated HOP is autophosphorylated and/or transphosphorylated", "reversible": "false", "notes": "The activated HOPs phosphorylate themselves and each other. The precise residue position where this takes place is currently unknown as there are many potential phosphorylation sites on HOP.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_209160", "map_id": "none", "name": "Phosphorylated HOP phosphorylates DOME", "reversible": "false", "notes": "Tyr966 on the cytoplasmic tail of the DOME receptor is phosphorylated by phosphorylated HOP.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206942", "map_id": "none", "name": "Phospho HOP:Phospho DOME:UPD:Phospho DOME:Phospho HOP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209231", "map_id": "none", "name": "DOME:HOP complex forms a dimer at the plasma membrane", "reversible": "false", "notes": "The HOP:DOME:DOME:HOP complex formation precedes ligand binding", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_206890", "map_id": "none", "name": "HOP:DOME", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209245", "map_id": "none", "name": "Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex", "reversible": "false", "notes": "The Domeless (DOME) cytokine receptor contains no tyrosine kinase domain. However, it is constitutively associated with the JAK tyrosine kinase, Hopscotch (HOP).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206172", "map_id": "Q9VWE0", "name": "DOME", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_206271", "map_id": "Q24592", "name": "HOP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209296", "map_id": "none", "name": "SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription", "reversible": "false", "notes": "The negative pathway regulator SU(VAR)2-10 physically interacts with the phosphorylated STAT92E dimer and prevents it from binding to it's pathway target genes and so inhibiting transcription.SU(VAR)2-10 is a PIAS protein (protein inhibitors of activated STAT) and is also referred to as ZIMP protein.In vertebrates, PIAS proteins control the duration of JAK/STAT signalling by targeting active STAT for degradation by SUMOlation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_205759", "map_id": "Q7KNF5", "name": "SU(VAR)2-10", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_206936", "map_id": "none", "name": "SU(VAR)2-10:Phospho STAT92E:Phospho STAT92E", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7KNF5", "map_id": "Q7KNF5", "name": "SU(VAR)2-10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "SU(VAR)2-10", "map_id": "SU(VAR)2-10", "name": "SU(VAR)2-10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_210700", "map_id": "none", "name": "KEN dimer represses transcription", "reversible": "false", "notes": "In the nucleus, the BCL6 orthologue, Ken and Barbie (KEN) dimer binds to GAAA sequences of the target gene DNA sequence. These overlap with some STAT92E binding sites and leads to transcription repression.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_210679", "map_id": "none", "name": "KEN dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O77459", "map_id": "O77459", "name": "KEN", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "KEN", "map_id": "KEN", "name": "KEN", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_209361", "map_id": "none", "name": "STAT92E binds to phosphorylated HOP and phosphorylated DOME", "reversible": "false", "notes": "The phosphorylated residues on HOP and DOME form a docking site for the SH2 domains of STAT92E molecules and so a complex is formed involving these domains.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206838", "map_id": "none", "name": "STAT92E:Phospho HOP:Phospho DOME:UPD:Phospho DOME:Phospho HOP:STAT92E", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209365", "map_id": "none", "name": "Phosphorylated STAT92E dimer transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated STAT92E dimer is translocated to the nucleus.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_209210", "map_id": "none", "name": "STAT92E is phosphorylated by phosphorylated HOP", "reversible": "false", "notes": "Tyr711 on STAT92E is phosphorylated by phosphorylated HOP tyrosine kinase.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206806", "map_id": "none", "name": "Phospho STAT92E:Phospho HOP:Phospho DOME:UPD:Phospho DOME:Phospho HOP:Phospho STAT92E", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209321", "map_id": "none", "name": "Phosphorylated STAT92E dissociates from HOP and DOME and dimerises", "reversible": "false", "notes": "After STAT92E is phosphorylated, it dissociates from phosphorylated HOP and phosphorylated DOME or the receptor complex. The now free phosphorylated STAT92E forms a dimer with another phosphorylated STAT92E molecule. These dimers are stabilised by the interaction between the SH2 domain of one molecule and the phospho Tyr of the other.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10446644", "map_id": "none", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10491859", "map_id": "none", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435578", "map_id": "none", "name": "Homologues of EEF1A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491851", "map_id": "none", "name": "Homologues of Me3K79-EEF1A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491856", "map_id": "Q9VMH7", "name": "N6AMT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031777", "map_id": "FBgn0031777", "name": "N6AMT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491942", "map_id": "none", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491934", "map_id": "none", "name": "Homologues of Me3K318-EEF1A1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10491939", "map_id": "Q9VQJ8", "name": "Dmel\\CG9643", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031485", "map_id": "FBgn0031485", "name": "Dmel\\CG9643", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491880", "map_id": "none", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491872", "map_id": "Q7KN62", "name": "TER94", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10491877", "map_id": "Q9VWJ9", "name": "Dmel\\CG7889", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031003", "map_id": "FBgn0031003", "name": "Dmel\\CG7889", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491839", "map_id": "none", "name": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10491831", "map_id": "P31009", "name": "RpS2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10491836", "map_id": "Q9VFB3", "name": "Art3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0038306", "map_id": "FBgn0038306", "name": "Art3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490208", "map_id": "none", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490194", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8MQJ8", "map_id": "Q8MQJ8", "name": "Hip1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036309", "map_id": "FBgn0036309", "name": "Hip1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDF4", "map_id": "Q9VDF4", "name": "Cortactin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025865", "map_id": "FBgn0025865", "name": "Cortactin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KLE5", "map_id": "Q7KLE5", "name": "Amph", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027356", "map_id": "FBgn0027356", "name": "Amph", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9NCC3", "map_id": "Q9NCC3", "name": "SH3PX1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040475", "map_id": "FBgn0040475", "name": "SH3PX1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10490201", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10490368", "map_id": "none", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490203", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10490359", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10489506", "map_id": "none", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489326", "map_id": "none", "name": "FCHO1,2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10489339", "map_id": "Q6AWD5", "name": "Dmel\\CG8176", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10489337", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10489331", "map_id": "Q8MQS4", "name": "Reps", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439052", "map_id": "Q9W111", "name": "Eps-15", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442542", "map_id": "M9ND00", "name": "Dap160", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10489341", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10490921", "map_id": "none", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10490919", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "Q9VMY8", "map_id": "Q9VMY8", "name": "aux", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037218", "map_id": "FBgn0037218", "name": "aux", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489311", "map_id": "Q9VJ30", "name": "Nak", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10490404", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10490923", "map_id": "none", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10490917", "map_id": "none", "name": "GGC-RAB5:GDP:GAPVD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10490352", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10490925", "map_id": "none", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447882", "map_id": "none", "name": "Clathrin Triskelion", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10489357", "map_id": "none", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10489347", "map_id": "none", "name": "NECAPs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10489349", "map_id": "none", "name": "PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10489355", "map_id": "none", "name": "ARFGAP1:ARF6:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VTX5", "map_id": "Q9VTX5", "name": "ArfGAP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020655", "map_id": "FBgn0020655", "name": "ArfGAP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490190", "map_id": "none", "name": "SNX9 recruits components of the actin polymerizing machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490175", "map_id": "none", "name": "HIP1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10490171", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10490186", "map_id": "none", "name": "ARP2/3 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10490184", "map_id": "Q9VDF4", "name": "Cortactin", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10490179", "map_id": "none", "name": "HIP1R dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10490188", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10490130", "map_id": "none", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490118", "map_id": "none", "name": "CLASP proteins:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10490120", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10490196", "map_id": "none", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10490192", "map_id": "none", "name": "DNM:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10490133", "map_id": "none", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447052", "map_id": "Q0E8Y1", "name": "PIP5K59B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10490357", "map_id": "none", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10490350", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "species_10490354", "map_id": "none", "name": "clathrin:HSPA8:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10490135", "map_id": "none", "name": "Clathrin recruits PIK3C2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10461053", "map_id": "Q7K3H0", "name": "Pi3K68D", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10490122", "map_id": "none", "name": "PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10489368", "map_id": "none", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10490138", "map_id": "none", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10490363", "map_id": "none", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10447997", "map_id": "Q9VMY8", "name": "aux", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10490361", "map_id": "none", "name": "PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10490365", "map_id": "none", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane" }, { "id": "species_10471267", "map_id": "none", "name": "HSPA8:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10490206", "map_id": "none", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10439917", "map_id": "none", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439913", "map_id": "none", "name": "Invaginating gap junction plaques", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "Q01989", "map_id": "Q01989", "name": "jar", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011225", "map_id": "FBgn0011225", "name": "jar", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439915", "map_id": "none", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439857", "map_id": "Q01989", "name": "jar", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10439852", "map_id": "none", "name": "Planar gap junction plaques associated with Dab2 and Dynamin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10440628", "map_id": "none", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10439834", "map_id": "none", "name": "planar gap junction plaques", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10439839", "map_id": "P98081", "name": "Dab", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10439841", "map_id": "none", "name": "planar gap junction plaques associated with Dab2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10440626", "map_id": "none", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10486354", "map_id": "none", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10486350", "map_id": "none", "name": "ARF:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10486342", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "A1Z8W8", "map_id": "A1Z8W8", "name": "garz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486352", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10486755", "map_id": "none", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10486749", "map_id": "none", "name": "cis-Golgi cis SNARE bundle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10486753", "map_id": "none", "name": "cis-SNARE:3xSNAP:NSF hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10486564", "map_id": "none", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10486475", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "Q86BA5", "map_id": "Q86BA5", "name": "p24-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053105", "map_id": "FBgn0053105", "name": "p24-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7K5", "map_id": "Q9I7K5", "name": "eca", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0069242", "map_id": "FBgn0069242", "name": "eca", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYT6", "map_id": "Q9VYT6", "name": "p24-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030341", "map_id": "FBgn0030341", "name": "p24-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SXY6", "map_id": "Q8SXY6", "name": "bai", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0045866", "map_id": "FBgn0045866", "name": "bai", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4K0", "map_id": "Q9W4K0", "name": "CHOp24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O76767", "map_id": "O76767", "name": "KdelR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267330", "map_id": "FBgn0267330", "name": "KdelR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VV89", "map_id": "Q9VV89", "name": "zetaCOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040512", "map_id": "FBgn0040512", "name": "zetaCOP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W555", "map_id": "Q9W555", "name": "deltaCOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028969", "map_id": "FBgn0028969", "name": "deltaCOP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I0G5", "map_id": "Q8I0G5", "name": "gammaCOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028968", "map_id": "FBgn0028968", "name": "gammaCOP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P45437", "map_id": "P45437", "name": "betaCOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0008635", "map_id": "FBgn0008635", "name": "betaCOP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0B8", "map_id": "Q9W0B8", "name": "alphaCOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025725", "map_id": "FBgn0025725", "name": "alphaCOP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62621", "map_id": "O62621", "name": "beta'COP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025724", "map_id": "FBgn0025724", "name": "beta'COP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y0Y5", "map_id": "Q9Y0Y5", "name": "epsilonCOP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027496", "map_id": "FBgn0027496", "name": "epsilonCOP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JNX0", "map_id": "A8JNX0", "name": "ArfGAP3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037182", "map_id": "FBgn0037182", "name": "ArfGAP3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486421", "map_id": "none", "name": "ARFGAP1,2,3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10486340", "map_id": "A1Z8W8", "name": "garz", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10486561", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10486407", "map_id": "none", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10486358", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10486403", "map_id": "none", "name": "coatomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10486405", "map_id": "none", "name": "RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "reaction_10486344", "map_id": "none", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "reaction_10486361", "map_id": "none", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "reaction_10486587", "map_id": "none", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_432051", "compartment_display": "transport vesicle" }, { "id": "species_10473488", "map_id": "none", "name": "Dynein:Dynactin:microtubule", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P37276", "map_id": "P37276", "name": "Dhc64C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261797", "map_id": "FBgn0261797", "name": "Dhc64C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZ20", "map_id": "Q9VZ20", "name": "Dlic", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030276", "map_id": "FBgn0030276", "name": "Dlic", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KWG3", "map_id": "Q7KWG3", "name": "Sdic2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053497", "map_id": "FBgn0053497", "name": "Sdic2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "T2FGB0", "map_id": "T2FGB0", "name": "SdicC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283434", "map_id": "FBgn0283434", "name": "SdicC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24246", "map_id": "Q24246", "name": "sw", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003654", "map_id": "FBgn0003654", "name": "sw", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W5W4", "map_id": "Q9W5W4", "name": "Sdic1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0067861", "map_id": "FBgn0067861", "name": "Sdic1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B5RJJ8", "map_id": "B5RJJ8", "name": "Sdic4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0053499", "map_id": "FBgn0053499", "name": "Sdic4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IRZ3", "map_id": "Q8IRZ3", "name": "Sdic3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052823", "map_id": "FBgn0052823", "name": "Sdic3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P45889", "map_id": "P45889", "name": "Arp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011745", "map_id": "FBgn0011745", "name": "Arp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K130", "map_id": "Q7K130", "name": "DCTN4-p62", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033206", "map_id": "FBgn0033206", "name": "DCTN4-p62", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIZ1", "map_id": "Q9VIZ1", "name": "DCTN6-p27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086446", "map_id": "FBgn0086446", "name": "DCTN6-p27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJQ6", "map_id": "Q9VJQ6", "name": "DCTN5-p25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040228", "map_id": "FBgn0040228", "name": "DCTN5-p25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWE8", "map_id": "Q9VWE8", "name": "Arp10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031050", "map_id": "FBgn0031050", "name": "Arp10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P13496", "map_id": "P13496", "name": "DCTN1-p150", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001108", "map_id": "FBgn0001108", "name": "DCTN1-p150", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1V8", "map_id": "Q9W1V8", "name": "DCTN3-p24", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010622", "map_id": "FBgn0010622", "name": "DCTN3-p24", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K2D2", "map_id": "Q7K2D2", "name": "DCTN2-p50", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0021825", "map_id": "FBgn0021825", "name": "DCTN2-p50", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486585", "map_id": "none", "name": "RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10486477", "map_id": "none", "name": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane" }, { "id": "species_10486473", "map_id": "none", "name": "Spectrin tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10478762", "map_id": "Q9W3M8", "name": "Ykt6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "species_10486467", "map_id": "none", "name": "ERGIC-to-cis-Golgi cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10486450", "map_id": "none", "name": "p24 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "true" }, { "id": "species_10449902", "map_id": "Q0KIE7", "name": "Ank", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10486751", "map_id": "none", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10486730", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q9VMD2", "map_id": "Q9VMD2", "name": "Dmel\\CG9536", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031818", "map_id": "FBgn0031818", "name": "Dmel\\CG9536", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486745", "map_id": "none", "name": "cis-Golgi t-SNARES", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10486747", "map_id": "none", "name": "RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10478860", "map_id": "none", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10478856", "map_id": "none", "name": "LMAN family receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10478844", "map_id": "none", "name": "glycosylated LMAN cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10478858", "map_id": "none", "name": "LMAN receptor:glycosylated cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10478888", "map_id": "none", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10478884", "map_id": "none", "name": "Homologues of GRIA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10478868", "map_id": "P49858", "name": "cni", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10478886", "map_id": "none", "name": "CNIH2,3:GRIA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10478866", "map_id": "none", "name": "MIA2 binds PREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10478862", "map_id": "Q9VMA7", "name": "Tango1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0286898", "map_id": "FBgn0286898", "name": "Tango1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10478864", "map_id": "none", "name": "MIA2:PREB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VMH4", "map_id": "Q9VMH4", "name": "Dmel\\CG9175", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMA7", "map_id": "Q9VMA7", "name": "Tango1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488161", "map_id": "none", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10488157", "map_id": "none", "name": "BICD dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P16568", "map_id": "P16568", "name": "BicD", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000183", "map_id": "FBgn0000183", "name": "BicD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488144", "map_id": "none", "name": "COPI-independent Golgi-to-ER cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10488159", "map_id": "none", "name": "RAB6:GTP:BICD dimer:COPI-independent retrograde cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10488321", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10488317", "map_id": "none", "name": "RAB18:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10488198", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10488319", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10488324", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10488204", "map_id": "none", "name": "RAB3GAP1:RAB3GAP2:RAB18:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10487912", "map_id": "none", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_429785", "map_id": "CHEBI:16110", "name": "PC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_6814303", "map_id": "CHEBI:35366", "name": "fatty acid", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8848483", "map_id": "CHEBI:17504", "name": "2-lysophosphatidylcholine", "type": "catalyst", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10488138", "map_id": "none", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10488135", "map_id": "none", "name": "Homologues of AGPAT3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10488172", "map_id": "none", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10488168", "map_id": "none", "name": "Dynein:Dynactin:microtubules:PAFAH1B1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7KNS3", "map_id": "Q7KNS3", "name": "Lis-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015754", "map_id": "FBgn0015754", "name": "Lis-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488170", "map_id": "none", "name": "RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10488166", "map_id": "Q7KNS3", "name": "Lis-1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488206", "map_id": "none", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10488186", "map_id": "none", "name": "RAB6:GTP:COPI-independent retrograde Golgi-to-ER cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10486977", "map_id": "none", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10486962", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "O18405", "map_id": "O18405", "name": "Surf4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019925", "map_id": "FBgn0019925", "name": "Surf4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486974", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10487089", "map_id": "none", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10487087", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo:NBAS:RINT1:ZW10:STX18:USE1L:BNIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VSU7", "map_id": "Q9VSU7", "name": "Use1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035965", "map_id": "FBgn0035965", "name": "Use1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNI9", "map_id": "Q9VNI9", "name": "Sec20", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037383", "map_id": "FBgn0037383", "name": "Sec20", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VC58", "map_id": "Q9VC58", "name": "Syx18", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039212", "map_id": "FBgn0039212", "name": "Syx18", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS46", "map_id": "Q9VS46", "name": "Rint1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035762", "map_id": "FBgn0035762", "name": "Rint1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4X9", "map_id": "Q9W4X9", "name": "Zw10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004643", "map_id": "FBgn0004643", "name": "Zw10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487085", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10487003", "map_id": "none", "name": "SEC22B:STX18:USE1L:BNIP1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10487051", "map_id": "none", "name": "p24 dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10486947", "map_id": "none", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10486943", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10486945", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GTP:coatomer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10486964", "map_id": "none", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10486954", "map_id": "M9PGI6", "name": "Sec22", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10486708", "map_id": "none", "name": "p24 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10486960", "map_id": "none", "name": "Golgi-to-ER cargo", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10486950", "map_id": "none", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10486939", "map_id": "none", "name": "RAB1:GTP:GBF1:ARF:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10486999", "map_id": "none", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10486996", "map_id": "none", "name": "SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10486987", "map_id": "Q9VC58", "name": "Syx18", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10486982", "map_id": "Q9VNI9", "name": "Sec20", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10478669", "map_id": "M9PGI6", "name": "Sec22", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10486992", "map_id": "Q9VSU7", "name": "Use1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10486952", "map_id": "none", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10486678", "map_id": "none", "name": "RAB1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10486937", "map_id": "none", "name": "RAB1:GTP:GBF1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10486941", "map_id": "none", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "reaction_10487005", "map_id": "none", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10487007", "map_id": "none", "name": "Retrograde COPI vesicles bind kinesin and microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_432051", "compartment_display": "transport vesicle" }, { "id": "species_10487001", "map_id": "none", "name": "RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_432051", "compartment_display": "transport vesicle", "complex": "true" }, { "id": "reaction_10487616", "map_id": "none", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10487612", "map_id": "none", "name": "STX6:STX16:VTI1A:VAMP4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10487614", "map_id": "none", "name": "STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10487651", "map_id": "none", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10487644", "map_id": "none", "name": "RAB43:GTP:USP6NL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "O18339", "map_id": "O18339", "name": "Rab19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015793", "map_id": "FBgn0015793", "name": "Rab19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487648", "map_id": "none", "name": "RAB43:GDP:USP6NL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10487252", "map_id": "none", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10487206", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "P25160", "map_id": "P25160", "name": "Arl1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000115", "map_id": "FBgn0000115", "name": "Arl1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W389", "map_id": "Q9W389", "name": "Arfrp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030088", "map_id": "FBgn0030088", "name": "Arfrp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHP1", "map_id": "Q9VHP1", "name": "Dmel\\CG11753", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037603", "map_id": "FBgn0037603", "name": "Dmel\\CG11753", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487248", "map_id": "none", "name": "TGN Golgin dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W1R3", "map_id": "Q9W1R3", "name": "Golgin245", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034854", "map_id": "FBgn0034854", "name": "Golgin245", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGR1", "map_id": "Q9VGR1", "name": "GCC88", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037881", "map_id": "FBgn0037881", "name": "GCC88", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K4K7", "map_id": "Q7K4K7", "name": "cbs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086757", "map_id": "FBgn0086757", "name": "cbs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3V2", "map_id": "Q9W3V2", "name": "Dmel\\CG4557", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029912", "map_id": "FBgn0029912", "name": "Dmel\\CG4557", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487250", "map_id": "none", "name": "AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10487270", "map_id": "none", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487266", "map_id": "Q9VB51", "name": "Dmel\\CG5934", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0039505", "map_id": "FBgn0039505", "name": "Dmel\\CG5934", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487200", "map_id": "none", "name": "MyrG-ARL1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10487268", "map_id": "none", "name": "SCOC:MyrG-ARL1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VB51", "map_id": "Q9VB51", "name": "Dmel\\CG5934", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487655", "map_id": "none", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10487642", "map_id": "none", "name": "RAB43:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10487653", "map_id": "A1Z9K4", "name": "RN-tre", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10487208", "map_id": "none", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10487192", "map_id": "none", "name": "AcM-ARFRP1:GTP:SYS1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10487562", "map_id": "none", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10487552", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10487560", "map_id": "none", "name": "STX10:STX16:VTI1A:VAMP3:NSF hexamer:SNAPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "reaction_10487261", "map_id": "none", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487257", "map_id": "Q9VGQ8", "name": "Arfip", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0037884", "map_id": "FBgn0037884", "name": "Arfip", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487259", "map_id": "none", "name": "ARFIP2:MyrG-ARL1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VGQ8", "map_id": "Q9VGQ8", "name": "Arfip", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487565", "map_id": "none", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10487508", "map_id": "Q9W0N6", "name": "Vti1a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "species_10487522", "map_id": "none", "name": "Homologues of VAMP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "species_10487506", "map_id": "Q9VR90", "name": "Syx16", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "species_10487504", "map_id": "Q7JY00", "name": "Syx6", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "reaction_10487214", "map_id": "none", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_10487182", "map_id": "Q9VHP1", "name": "Dmel\\CG11753", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "false" }, { "id": "species_10487212", "map_id": "none", "name": "AcM-ARFRP1:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10447993", "map_id": "none", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447892", "map_id": "none", "name": "Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "Q7KVR8", "map_id": "Q7KVR8", "name": "AP-1gamma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030089", "map_id": "FBgn0030089", "name": "AP-1gamma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "B8A403", "map_id": "B8A403", "name": "AP-1sigma", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039132", "map_id": "FBgn0039132", "name": "AP-1sigma", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O62531", "map_id": "O62531", "name": "AP-1mu", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024833", "map_id": "FBgn0024833", "name": "AP-1mu", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10439074", "map_id": "Q8T390", "name": "EndoA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10447990", "map_id": "none", "name": "Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "true" }, { "id": "species_10447884", "map_id": "P27619", "name": "shi", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10447894", "map_id": "none", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10447876", "map_id": "none", "name": "Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10444042", "map_id": "none", "name": "Arf1-GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10449633", "map_id": "none", "name": "Recruitment Of Cytoplasmic Proteins To Vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447984", "map_id": "none", "name": "Vamp", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_437051", "compartment_display": "cytoplasmic vesicle membrane", "complex": "false" }, { "id": "species_10449619", "map_id": "none", "name": "Ferritin Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VYH1", "map_id": "Q9VYH1", "name": "Fer3HCH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030449", "map_id": "FBgn0030449", "name": "Fer3HCH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449624", "map_id": "P25822", "name": "pum", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0003165", "map_id": "FBgn0003165", "name": "pum", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449610", "map_id": "Q8IN05", "name": "lqfR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0261279", "map_id": "FBgn0261279", "name": "lqfR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449629", "map_id": "Q9VE96", "name": "l(3)05822", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0010877", "map_id": "FBgn0010877", "name": "l(3)05822", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449631", "map_id": "none", "name": "Golgi-associated vesicle interacting proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VE96", "map_id": "Q9VE96", "name": "l(3)05822", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IN05", "map_id": "Q8IN05", "name": "lqfR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25822", "map_id": "P25822", "name": "pum", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475663", "map_id": "none", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10439057", "map_id": "Q960X8", "name": "Hrs", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10454937", "map_id": "Q9VBI3", "name": "Vps2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475659", "map_id": "Q7KVR8", "name": "AP-1gamma", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "species_10475661", "map_id": "none", "name": "AP1G2:HGS:CHMP2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10449498", "map_id": "none", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449493", "map_id": "none", "name": "Lysosome Destined Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "species_10449475", "map_id": "none", "name": "Lysosome Cargo:AP-1:Beta-arrestin:Clathrin Triskelion:Vamp Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10449495", "map_id": "none", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449489", "map_id": "none", "name": "Lysosome Destined Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10471574", "map_id": "none", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane" }, { "id": "species_5334668", "map_id": "CHEBI:16851", "name": "PI(3,5)P2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10471570", "map_id": "none", "name": "CLAT:AP1:CLVS", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_263163", "compartment_display": "trans-Golgi network membrane", "complex": "true" }, { "id": "Q9VTY1", "map_id": "Q9VTY1", "name": "Dmel\\CG10657", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036289", "map_id": "FBgn0036289", "name": "Dmel\\CG10657", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRP8", "map_id": "Q9VRP8", "name": "Cralbp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035636", "map_id": "FBgn0035636", "name": "Cralbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471572", "map_id": "none", "name": "CLAT:AP1:CLVS:PI(3,5)P2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "reaction_10444054", "map_id": "none", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444046", "map_id": "none", "name": "Arf1-GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10455085", "map_id": "none", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454980", "map_id": "none", "name": "ESCRT-III", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10455081", "map_id": "none", "name": "ESCRT-II/Cargo Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q9VD72", "map_id": "Q9VD72", "name": "lsn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260940", "map_id": "FBgn0260940", "name": "lsn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VU87", "map_id": "Q9VU87", "name": "Vps36", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086785", "map_id": "FBgn0086785", "name": "Vps36", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JXV9", "map_id": "Q7JXV9", "name": "Vps25", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022027", "map_id": "FBgn0022027", "name": "Vps25", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10455014", "map_id": "none", "name": "ESCRT-III/Cargo Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10455079", "map_id": "none", "name": "ESCRT-II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10455083", "map_id": "none", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455062", "map_id": "none", "name": "ESCRT-I/Cargo Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "Q9V359", "map_id": "Q9V359", "name": "Vps28", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0021814", "map_id": "FBgn0021814", "name": "Vps28", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VN88", "map_id": "Q9VN88", "name": "Vps37B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037299", "map_id": "FBgn0037299", "name": "Vps37B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O77259", "map_id": "O77259", "name": "Vsp37A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016038", "map_id": "FBgn0016038", "name": "Vsp37A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWY7", "map_id": "Q9VWY7", "name": "Mvb12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030894", "map_id": "FBgn0030894", "name": "Mvb12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHX1", "map_id": "Q9VHX1", "name": "Dmel\\CG10435", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037539", "map_id": "FBgn0037539", "name": "Dmel\\CG10435", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVA7", "map_id": "Q9VVA7", "name": "TSG101", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036666", "map_id": "FBgn0036666", "name": "TSG101", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10455060", "map_id": "none", "name": "ESCRT-I", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "reaction_10455091", "map_id": "none", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10455089", "map_id": "none", "name": "ESCRT-0/Cargo Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10455087", "map_id": "none", "name": "ESCRT-0", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465199", "map_id": "none", "name": "Hemopexin binds Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10465195", "map_id": "Q9W122", "name": "Mmp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10465197", "map_id": "none", "name": "HPX:Hemes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10442798", "map_id": "none", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_209911", "map_id": "CHEBI:17780", "name": "5HTP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442795", "map_id": "none", "name": "DDC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P05031", "map_id": "P05031", "name": "Ddc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000422", "map_id": "FBgn0000422", "name": "Ddc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10442780", "map_id": "none", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442777", "map_id": "none", "name": "TPH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W0K2", "map_id": "Q9W0K2", "name": "Trh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035187", "map_id": "FBgn0035187", "name": "Trh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449260", "map_id": "none", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449257", "map_id": "P00528", "name": "Src64B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10447546", "map_id": "none", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447543", "map_id": "none", "name": "cGMP phosphodiesterases", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10447521", "map_id": "none", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10448285", "map_id": "none", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_426219", "map_id": "none", "name": "Cations", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_426221", "map_id": "none", "name": "Cations", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10484607", "map_id": "none", "name": "TP53 binds HIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10484603", "map_id": "Q9W0Q1", "name": "Hipk", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0035142", "map_id": "FBgn0035142", "name": "Hipk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484605", "map_id": "none", "name": "TP53 Tetramer:HIPK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W0Q1", "map_id": "Q9W0Q1", "name": "Hipk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486113", "map_id": "none", "name": "CDK5 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486103", "map_id": "none", "name": "p-S15,S33,S46-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10486110", "map_id": "none", "name": "p-Y15,S159-CDK5:CDK5R1 (99-307)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10486083", "map_id": "none", "name": "CDK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486081", "map_id": "none", "name": "p-S315-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10484601", "map_id": "none", "name": "HIPK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467602", "map_id": "none", "name": "TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9NFM7", "map_id": "M9NFM7", "name": "DOR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035542", "map_id": "FBgn0035542", "name": "DOR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467600", "map_id": "none", "name": "p-HIPK2:PIN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10467592", "map_id": "M9NFM7", "name": "DOR", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10481386", "map_id": "none", "name": "p-S15,S20,S46-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10486087", "map_id": "none", "name": "AURKB binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470050", "map_id": "none", "name": "Homologues of AURKB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10467755", "map_id": "none", "name": "NOC2L:p-S15,S20-TP53", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VIF0", "map_id": "Q9VIF0", "name": "NOC2L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032925", "map_id": "FBgn0032925", "name": "NOC2L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486085", "map_id": "none", "name": "AURKB:NOC2L:p-S15,S20-TP53", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10486121", "map_id": "none", "name": "TAF1 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486118", "map_id": "none", "name": "p-T55-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10431420", "map_id": "none", "name": "TFIID", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10467604", "map_id": "none", "name": "TP53INP1 and HIPK2 bind TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10481389", "map_id": "none", "name": "DYRK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10481378", "map_id": "P83102", "name": "phospho-Dyrk3", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0027101", "map_id": "FBgn0027101", "name": "phospho-Dyrk3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467757", "map_id": "none", "name": "NOC2L binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467753", "map_id": "Q9VIF0", "name": "NOC2L", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10486098", "map_id": "none", "name": "AURKB phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486095", "map_id": "none", "name": "AURKB:NOC2L:p-S15,S20,S269,T284-TP53", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10486134", "map_id": "none", "name": "AMPK phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486131", "map_id": "none", "name": "Activated AMPK heterotrimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10486074", "map_id": "none", "name": "CK2:FACT phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486053", "map_id": "none", "name": "p-S15,S20,S392-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10486071", "map_id": "none", "name": "CK2:FACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10486076", "map_id": "none", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486069", "map_id": "none", "name": "Casein kinase II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10486142", "map_id": "none", "name": "TP53RK phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486139", "map_id": "Q9VRJ6", "name": "Prpk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0035590", "map_id": "FBgn0035590", "name": "Prpk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486000", "map_id": "none", "name": "TP53 binds POU4F1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10485996", "map_id": "P24350", "name": "acj6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0000028", "map_id": "FBgn0000028", "name": "acj6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485998", "map_id": "none", "name": "p-S15,S20-TP53 Tetramer:POU4F1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P24350", "map_id": "P24350", "name": "acj6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486006", "map_id": "none", "name": "TP53 binds POU4F2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486002", "map_id": "P24350", "name": "acj6", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10486004", "map_id": "none", "name": "p-S15,S20-TP53 Tetramer:POU4F2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10467785", "map_id": "none", "name": "PHF20 binds TP53 dimethylated on K370 and K382", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467781", "map_id": "none", "name": "Me2-K370,K382-TP53 Tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10467775", "map_id": "Q9VGA4", "name": "MBD-R2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0038016", "map_id": "FBgn0038016", "name": "phospho-MBD-R2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467783", "map_id": "none", "name": "PHF20:Me2-K370,K382-TP53 Tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VGA4", "map_id": "Q9VGA4", "name": "phospho-MBD-R2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486215", "map_id": "none", "name": "AKT phosphorylates PHF20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486213", "map_id": "Q9VGA4", "name": "phospho-MBD-R2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10484676", "map_id": "none", "name": "TP53 family members bind PPP1R13B or TP53BP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10481317", "map_id": "none", "name": "p-S15,S20-TP53,TP63,TP73", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10484670", "map_id": "Q86BG1", "name": "ASPP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0034606", "map_id": "FBgn0034606", "name": "ASPP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484674", "map_id": "none", "name": "(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q86BG1", "map_id": "Q86BG1", "name": "ASPP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486219", "map_id": "none", "name": "p-S291-PHF20 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486217", "map_id": "Q9VGA4", "name": "phospho-MBD-R2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10486046", "map_id": "none", "name": "TP53 forms homotetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467282", "map_id": "Q8IMZ4", "name": "p53", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10474397", "map_id": "none", "name": "DDIT4 binds 14-3-3 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474390", "map_id": "none", "name": "Homologues of DDIT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VTH4", "map_id": "Q9VTH4", "name": "scyl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041094", "map_id": "FBgn0041094", "name": "scyl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTI8", "map_id": "Q9VTI8", "name": "chrb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036165", "map_id": "FBgn0036165", "name": "chrb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474392", "map_id": "none", "name": "DDIT4:14-3-3 dimer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10474394", "map_id": "none", "name": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474378", "map_id": "none", "name": "p-S939,T1462-TSC2:14-3-3 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10474353", "map_id": "none", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474341", "map_id": "Q9W1K5", "name": "Sesn", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0034897", "map_id": "FBgn0034897", "name": "Sesn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10474351", "map_id": "none", "name": "SESN1,2,3:p-AMPK heterotrimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W1K5", "map_id": "Q9W1K5", "name": "Sesn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436944", "map_id": "none", "name": "Formation of TSC1:TSC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10436938", "map_id": "Q9VCC9", "name": "Tsc1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10474349", "map_id": "none", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10474333", "map_id": "none", "name": "HOOS-C52-PRDX1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10474347", "map_id": "none", "name": "SESN1,2,3:HOOS-C52-PRDX1 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10474336", "map_id": "none", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468393", "map_id": "none", "name": "PRDX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10481119", "map_id": "none", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434613", "map_id": "Q961D1", "name": "CycK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10481115", "map_id": "Q9VP22", "name": "Cdk12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0037093", "map_id": "FBgn0037093", "name": "Cdk12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10481117", "map_id": "none", "name": "CCNK:CDK13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VP22", "map_id": "Q9VP22", "name": "Cdk12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10481276", "map_id": "none", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10481111", "map_id": "none", "name": "CCNK:CDK12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10481256", "map_id": "none", "name": "Elongation Complex at DNA Repair Genes", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10481258", "map_id": "none", "name": "CCNK:CDK12:Elongation Complex at DNA Repair Genes", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10481274", "map_id": "none", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10481271", "map_id": "none", "name": "CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10481113", "map_id": "none", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10481109", "map_id": "Q9VP22", "name": "Cdk12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10485756", "map_id": "none", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10485748", "map_id": "none", "name": "Homologues of p-T788-PIDD1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q960C5", "map_id": "Q960C5", "name": "phospho-Lrch", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032633", "map_id": "FBgn0032633", "name": "phospho-Lrch", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2D7", "map_id": "Q9W2D7", "name": "phospho-Dmel\\CG10307", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034655", "map_id": "FBgn0034655", "name": "phospho-Dmel\\CG10307", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485754", "map_id": "none", "name": "Homologues of p-T788-PIDD1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10485783", "map_id": "none", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10485772", "map_id": "none", "name": "RGGT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VN77", "map_id": "Q9VN77", "name": "RabGGTalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037293", "map_id": "FBgn0037293", "name": "RabGGTalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZ68", "map_id": "Q9XZ68", "name": "betaggt-II", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028970", "map_id": "FBgn0028970", "name": "betaggt-II", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485779", "map_id": "Q9V8W3", "name": "Rep", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10485781", "map_id": "none", "name": "RGGT:CHM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10485774", "map_id": "none", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10485770", "map_id": "Q9XZ68", "name": "betaggt-II", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10485765", "map_id": "Q9VN77", "name": "RabGGTalpha", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10485804", "map_id": "none", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_10485788", "map_id": "Q6NLJ9", "name": "Dmel\\CG30109", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "FBgn0050109", "map_id": "FBgn0050109", "name": "Dmel\\CG30109", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485800", "map_id": "none", "name": "PRELID1, PRELID3A", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q9V579", "map_id": "Q9V579", "name": "prel", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033413", "map_id": "FBgn0033413", "name": "prel", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485802", "map_id": "none", "name": "TRIAP1:PRELID1, PRELID3A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q6NLJ9", "map_id": "Q6NLJ9", "name": "Dmel\\CG30109", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10485807", "map_id": "none", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "reaction_10430972", "map_id": "none", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500829", "map_id": "none", "name": "Cyt-Rib, dC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:15698", "map_id": "CHEBI:15698", "name": "CHEBI:15698", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_500430", "map_id": "none", "name": "(d)Ura", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16450", "map_id": "CHEBI:16450", "name": "CHEBI:16450", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10430969", "map_id": "none", "name": "CDA tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VLR3", "map_id": "Q9VLR3", "name": "Dmel\\CG8360", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032001", "map_id": "FBgn0032001", "name": "Dmel\\CG8360", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433723", "map_id": "none", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_500822", "map_id": "none", "name": "dC, Thy-dRib, dU", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_500823", "map_id": "none", "name": "dCMP, TMP, dUMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10433720", "map_id": "Q9XZT6", "name": "dnk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0022338", "map_id": "FBgn0022338", "name": "dnk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431579", "map_id": "none", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83962", "map_id": "CHEBI:17568", "name": "Ura", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431576", "map_id": "none", "name": "UPP1, UPP2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VBA0", "map_id": "Q9VBA0", "name": "Dmel\\CG6330", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039464", "map_id": "FBgn0039464", "name": "Dmel\\CG6330", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T8S2", "map_id": "Q8T8S2", "name": "Dmel\\CG3788", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034800", "map_id": "FBgn0034800", "name": "Dmel\\CG3788", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E8U4", "map_id": "Q0E8U4", "name": "Dmel\\CG17224", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031489", "map_id": "FBgn0031489", "name": "Dmel\\CG17224", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10433803", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500759", "map_id": "none", "name": "Cyt-Rib, Ura-Rib", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500761", "map_id": "none", "name": "CMP, UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433800", "map_id": "none", "name": "UCK2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VC99", "map_id": "Q9VC99", "name": "Uck", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263398", "map_id": "FBgn0263398", "name": "Uck", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430952", "map_id": "none", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430949", "map_id": "none", "name": "UCK1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10479975", "map_id": "none", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6788291", "map_id": "CHEBI:18116", "name": "PURIDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6788290", "map_id": "CHEBI:17802", "name": "PURID", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479972", "map_id": "none", "name": "HDHD1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q94529", "map_id": "Q94529", "name": "Gs1l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019982", "map_id": "FBgn0019982", "name": "Gs1l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495070", "map_id": "none", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495067", "map_id": "Q8MQK4", "name": "l(2)k01209", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0022029", "map_id": "FBgn0022029", "name": "l(2)k01209", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427902", "map_id": "none", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30170", "map_id": "CHEBI:17973", "name": "Gal1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10427899", "map_id": "Q9VMA2", "name": "Galt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0263200", "map_id": "FBgn0263200", "name": "Galt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427912", "map_id": "none", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427909", "map_id": "none", "name": "GALE:NAD+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W0P5", "map_id": "Q9W0P5", "name": "Gale", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035147", "map_id": "FBgn0035147", "name": "Gale", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427975", "map_id": "none", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427861", "map_id": "none", "name": "PGM:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10488852", "map_id": "none", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_8853396", "map_id": "CHEBI:91280", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_6799577", "map_id": "CHEBI:91279", "name": "alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_6799594", "map_id": "CHEBI:4208", "name": "Man", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10488849", "map_id": "none", "name": "MAN2B1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q8IPB7", "map_id": "Q8IPB7", "name": "LManII", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027611", "map_id": "FBgn0027611", "name": "LManII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10484649", "map_id": "none", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_8853719", "map_id": "CHEBI:71553", "name": "GlcNAc:Man", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10484646", "map_id": "none", "name": "MAN2B2:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9VKV2", "map_id": "Q9VKV2", "name": "LManI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032253", "map_id": "FBgn0032253", "name": "LManI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLI1", "map_id": "Q9VLI1", "name": "LManIV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032067", "map_id": "FBgn0032067", "name": "LManIV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLI0", "map_id": "Q9VLI0", "name": "LManV", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032068", "map_id": "FBgn0032068", "name": "LManV", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLH9", "map_id": "Q9VLH9", "name": "LManVI", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032069", "map_id": "FBgn0032069", "name": "LManVI", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLI2", "map_id": "Q9VLI2", "name": "LManIII", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032066", "map_id": "FBgn0032066", "name": "LManIII", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488857", "map_id": "none", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10488854", "map_id": "Q9VMY5", "name": "beta-Man", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "FBgn0037215", "map_id": "FBgn0037215", "name": "beta-Man", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497920", "map_id": "none", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497917", "map_id": "none", "name": "PGM1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VUY9", "map_id": "Q9VUY9", "name": "Pgm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003076", "map_id": "FBgn0003076", "name": "Pgm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428999", "map_id": "none", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428910", "map_id": "none", "name": "PGYM dimer, b form", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9XTL9", "map_id": "Q9XTL9", "name": "phospho-GlyP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004507", "map_id": "FBgn0004507", "name": "phospho-GlyP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10428915", "map_id": "none", "name": "PGYM dimer a form", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10428996", "map_id": "none", "name": "phosphorylase kinase complex (PHKM)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VLS1", "map_id": "Q9VLS1", "name": "PHKB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031995", "map_id": "FBgn0031995", "name": "PHKB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W391", "map_id": "Q9W391", "name": "PHKA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030087", "map_id": "FBgn0030087", "name": "PHKA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10451638", "map_id": "none", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10451634", "map_id": "none", "name": "PGYM b dimer:AMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10428063", "map_id": "none", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428060", "map_id": "none", "name": "FBP tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A0A0U1RVK6", "map_id": "A0A0U1RVK6", "name": "fbp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032820", "map_id": "FBgn0032820", "name": "fbp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468121", "map_id": "none", "name": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_113782", "map_id": "CHEBI:58225", "name": "G6P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_113780", "map_id": "CHEBI:17925", "name": "Glc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10468118", "map_id": "Q9VQH1", "name": "G6P", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0031463", "map_id": "FBgn0031463", "name": "G6P", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444376", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_372364", "map_id": "CHEBI:58702", "name": "PEP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10444373", "map_id": "P20007", "name": "Pepck", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0003067", "map_id": "FBgn0003067", "name": "Pepck", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444312", "map_id": "none", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10440823", "map_id": "none", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440820", "map_id": "none", "name": "malate dehydrogenase 1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VKX2", "map_id": "Q9VKX2", "name": "Mdh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262782", "map_id": "FBgn0262782", "name": "Mdh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427830", "map_id": "none", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10427827", "map_id": "none", "name": "Homologues of PCK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P20007", "map_id": "P20007", "name": "Pepck", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JXB5", "map_id": "Q7JXB5", "name": "Pepck2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034356", "map_id": "FBgn0034356", "name": "Pepck2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428116", "map_id": "none", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428113", "map_id": "none", "name": "pyruvate carboxylase holoenzyme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10468116", "map_id": "none", "name": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468111", "map_id": "Q8MLW5", "name": "MFS16", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0034611", "map_id": "FBgn0034611", "name": "MFS16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10440813", "map_id": "none", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10440810", "map_id": "none", "name": "SLC25A11 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VAJ9", "map_id": "Q9VAJ9", "name": "Dmel\\CG1907", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039674", "map_id": "FBgn0039674", "name": "Dmel\\CG1907", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445386", "map_id": "none", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10468169", "map_id": "none", "name": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10468166", "map_id": "Q9VQH1", "name": "G6P", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10428264", "map_id": "none", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10429153", "map_id": "none", "name": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10429150", "map_id": "Q9VQH1", "name": "G6P", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10474612", "map_id": "none", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5652213", "map_id": "CHEBI:17924", "name": "D-sorbitol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10474624", "map_id": "none", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10427884", "map_id": "none", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31221", "map_id": "CHEBI:18105", "name": "Fru 1-P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10427881", "map_id": "none", "name": "KHK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VW84", "map_id": "Q9VW84", "name": "Dmel\\CG7328", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036942", "map_id": "FBgn0036942", "name": "Dmel\\CG7328", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10484615", "map_id": "none", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6799497", "map_id": "CHEBI:32398", "name": "DGA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6799493", "map_id": "CHEBI:58272", "name": "3PDGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10484612", "map_id": "Q9VQC4", "name": "Glyctk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031428", "map_id": "FBgn0031428", "name": "Glyctk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10427894", "map_id": "none", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30393", "map_id": "CHEBI:17378", "name": "GA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10427891", "map_id": "none", "name": "ALDOB tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440638", "map_id": "none", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193124", "map_id": "CHEBI:28750", "name": "17aHPREG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_196366", "map_id": "CHEBI:63843", "name": "pregn-5-ene-3,20-dione-17-ol", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10440398", "map_id": "none", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193092", "map_id": "CHEBI:17252", "name": "17aHPROG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10459245", "map_id": "none", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_1449707", "map_id": "none", "name": "Corticosteroids", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:27584", "map_id": "CHEBI:27584", "name": "CHEBI:27584", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_193977", "map_id": "CHEBI:17650", "name": "CORT", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "CHEBI:16973", "map_id": "CHEBI:16973", "name": "CHEBI:16973", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10459241", "map_id": "none", "name": "Homologues of SERPINA6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10459243", "map_id": "none", "name": "CBG:Corticosteroids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10440406", "map_id": "none", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_194035", "map_id": "CHEBI:16962", "name": "COR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10440403", "map_id": "P91615", "name": "Adhr", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10489504", "map_id": "none", "name": "HSD17B2 oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10489501", "map_id": "P91615", "name": "Adhr", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10479237", "map_id": "none", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5696835", "map_id": "CHEBI:16469", "name": "EST17b", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_5696848", "map_id": "CHEBI:17263", "name": "E1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10479234", "map_id": "none", "name": "Homologues of AKR1B15", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10478098", "map_id": "none", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_193132", "map_id": "CHEBI:16469", "name": "EST17b", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10478095", "map_id": "none", "name": "Homologues of HSD17B11", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10440273", "map_id": "none", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10496005", "map_id": "none", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491664", "map_id": "none", "name": "RUNX2:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10495911", "map_id": "none", "name": "p-S451-RUNX2:CBFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492400", "map_id": "none", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492396", "map_id": "Q94901", "name": "lark", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0011640", "map_id": "FBgn0011640", "name": "lark", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10492398", "map_id": "none", "name": "RUNX2:RBM14", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q94901", "map_id": "Q94901", "name": "lark", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491660", "map_id": "none", "name": "Activated AR binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10473354", "map_id": "none", "name": "AR:androgen", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10491658", "map_id": "none", "name": "RUNX2:AR:androgen", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10491668", "map_id": "none", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491662", "map_id": "none", "name": "p-2S-SMAD1:p-2S-SMAD1:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10491666", "map_id": "none", "name": "RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495959", "map_id": "none", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495951", "map_id": "none", "name": "p-S432-RUNX2:CBFB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10495956", "map_id": "Q9W4H8", "name": "Pp2C1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0022768", "map_id": "FBgn0022768", "name": "Pp2C1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495914", "map_id": "none", "name": "CDK4 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10493280", "map_id": "none", "name": "CDK4/6:CCND", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495757", "map_id": "none", "name": "RUNX2 binds SOX9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10474272", "map_id": "Q9VA17", "name": "Sox100B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10495755", "map_id": "none", "name": "RUNX2:SOX9", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10449051", "map_id": "none", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449036", "map_id": "none", "name": "Translatable mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K581", "map_id": "Q7K581", "name": "Dmel\\CG8963", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034181", "map_id": "FBgn0034181", "name": "Dmel\\CG8963", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10449024", "map_id": "none", "name": "Partially Deadenylated mRNA Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10449048", "map_id": "none", "name": "PAN2-PAN3 Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q95RR8", "map_id": "Q95RR8", "name": "PAN3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035397", "map_id": "FBgn0035397", "name": "PAN3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7K9", "map_id": "A1Z7K9", "name": "PAN2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033352", "map_id": "FBgn0033352", "name": "PAN2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493178", "map_id": "none", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6782337", "map_id": "CHEBI:73747", "name": "uridine residue", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10493168", "map_id": "none", "name": "Uridylated partially Deadenylated mRNA Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10493173", "map_id": "Q95U58", "name": "mkg-p", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0035889", "map_id": "FBgn0035889", "name": "mkg-p", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488832", "map_id": "none", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1221562", "map_id": "P15357", "name": "UBI-P63E 11", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430300", "map_id": "P15357", "name": "RpS27A", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10488829", "map_id": "none", "name": "UCHL3,USP7,USP9X", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P35122", "map_id": "P35122", "name": "Uch", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010288", "map_id": "FBgn0010288", "name": "Uch", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488784", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10488611", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8T0L3", "map_id": "Q8T0L3", "name": "Uba1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023143", "map_id": "FBgn0023143", "name": "Uba1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488710", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10488771", "map_id": "none", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10488732", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9I7T6", "map_id": "Q9I7T6", "name": "Dmel\\CG10862", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035455", "map_id": "FBgn0035455", "name": "Dmel\\CG10862", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQ00", "map_id": "Q9VQ00", "name": "Dmel\\CG5440", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031331", "map_id": "FBgn0031331", "name": "Dmel\\CG5440", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYN3", "map_id": "Q9VYN3", "name": "Dmel\\CG2574", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030386", "map_id": "FBgn0030386", "name": "Dmel\\CG2574", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUR4", "map_id": "Q9VUR4", "name": "Dmel\\CG7656", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036516", "map_id": "FBgn0036516", "name": "Dmel\\CG7656", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8B5", "map_id": "A1Z8B5", "name": "Ube2W", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033544", "map_id": "FBgn0033544", "name": "Ube2W", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488712", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10488769", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10488836", "map_id": "none", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488834", "map_id": "P18101", "name": "RpL40", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1221561", "map_id": "P18101", "name": "UBI-P63E 12", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430729", "map_id": "P18101", "name": "RpL40", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488708", "map_id": "none", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488649", "map_id": "none", "name": "Ub-Cys632-UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10488615", "map_id": "none", "name": "E2 ubiquitin conjugating enzyme (UBA1 substrate)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7JW03", "map_id": "Q7JW03", "name": "UbcE2H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029996", "map_id": "FBgn0029996", "name": "UbcE2H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q29R09", "map_id": "Q29R09", "name": "Dmel\\CG2924", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023528", "map_id": "FBgn0023528", "name": "Dmel\\CG2924", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXE8", "map_id": "Q9VXE8", "name": "Ubc7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267384", "map_id": "FBgn0267384", "name": "Ubc7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P52486", "map_id": "P52486", "name": "Ubc4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015321", "map_id": "FBgn0015321", "name": "Ubc4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SYG3", "map_id": "Q8SYG3", "name": "BcDNA:RE63412", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0058045", "map_id": "FBgn0058045", "name": "BcDNA:RE63412", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488651", "map_id": "none", "name": "UBA1:ubiquitin adenylate", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10488706", "map_id": "none", "name": "Ub:E2 (UBA1 substrate)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10488613", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10488565", "map_id": "Q8T0L3", "name": "Uba1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10488773", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10488776", "map_id": "none", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488617", "map_id": "none", "name": "Ub-Cys632-UBA1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10488841", "map_id": "none", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488838", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426977", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426979", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426981", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426983", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426985", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426969", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426971", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426973", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10426975", "map_id": "Q9W418", "name": "Ubi-p5E", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10477601", "map_id": "Q9VZU7", "name": "Usp5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488779", "map_id": "none", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10488845", "map_id": "none", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10488843", "map_id": "P0CG69", "name": "Ubi-p63E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1221567", "map_id": "P0CG69", "name": "UBI-P63E 1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1221557", "map_id": "P0CG69", "name": "UBI-P63E 2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1221559", "map_id": "P0CG69", "name": "UBI-P63E 3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10488782", "map_id": "none", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457011", "map_id": "Q8T0L3", "name": "Uba1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10495281", "map_id": "none", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495278", "map_id": "Q45VV3", "name": "phospho-yki", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10476652", "map_id": "P00522", "name": "phospho-Abl", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10495297", "map_id": "none", "name": "ITCH polyubiquitinates TP73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495289", "map_id": "none", "name": "TP73 Tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10495294", "map_id": "none", "name": "PolyUb-TP73 tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495299", "map_id": "none", "name": "TP73 tetramer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10481315", "map_id": "none", "name": "TP73 Tetramer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495269", "map_id": "none", "name": "RUNX1 binds the core TAL1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495265", "map_id": "none", "name": "TAL1 core complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "M9PI02", "map_id": "M9PI02", "name": "Bx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265598", "map_id": "FBgn0265598", "name": "Bx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4X2", "map_id": "Q9W4X2", "name": "HLH3B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011276", "map_id": "FBgn0011276", "name": "HLH3B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KVG9", "map_id": "Q7KVG9", "name": "Chi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013764", "map_id": "FBgn0013764", "name": "Chi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495267", "map_id": "none", "name": "RUNX1:CBFB:TAL1 core complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495285", "map_id": "none", "name": "YAP1 binds TP73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495283", "map_id": "none", "name": "p-Y407-YAP1:TP73 tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495301", "map_id": "none", "name": "26S proteasome degrades TP73 polyubiquitinated by ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10489814", "map_id": "none", "name": "KMT2A (MLL) binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489810", "map_id": "P20659", "name": "trx", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10489812", "map_id": "none", "name": "RUNX1:CBFB:KMT2A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495274", "map_id": "none", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495272", "map_id": "none", "name": "RUNX1:CBFB:YAP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10438764", "map_id": "none", "name": "Association of MCM8 with ORC:origin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10426938", "map_id": "Q9VF30", "name": "rec", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10427248", "map_id": "none", "name": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10482653", "map_id": "none", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane" }, { "id": "species_10482575", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6799713", "compartment_display": "tertiary granule membrane", "complex": "true" }, { "id": "O96692", "map_id": "O96692", "name": "Rap2l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283666", "map_id": "FBgn0283666", "name": "Rap2l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMJ6", "map_id": "Q9VMJ6", "name": "Tsp26A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031760", "map_id": "FBgn0031760", "name": "Tsp26A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q6NP91", "map_id": "Q6NP91", "name": "Tmem63", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033259", "map_id": "FBgn0033259", "name": "Tmem63", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQC6", "map_id": "Q8IQC6", "name": "BcDNA:RE03722", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052039", "map_id": "FBgn0052039", "name": "BcDNA:RE03722", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49283", "map_id": "P49283", "name": "Mvl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLT5", "map_id": "Q9VLT5", "name": "poe", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011230", "map_id": "FBgn0011230", "name": "poe", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPJ0", "map_id": "Q9VPJ0", "name": "CT31762", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031217", "map_id": "FBgn0031217", "name": "CT31762", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z6W9", "map_id": "A1Z6W9", "name": "pwn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003174", "map_id": "FBgn0003174", "name": "pwn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VS89", "map_id": "Q9VS89", "name": "frac", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035798", "map_id": "FBgn0035798", "name": "frac", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P09478", "map_id": "P09478", "name": "nAChRalpha1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000036", "map_id": "FBgn0000036", "name": "nAChRalpha1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10482651", "map_id": "none", "name": "Tertiary granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10483433", "map_id": "none", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_10483133", "map_id": "none", "name": "Secretory granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "true" }, { "id": "Q9VDL0", "map_id": "Q9VDL0", "name": "Srp14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038808", "map_id": "FBgn0038808", "name": "Srp14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHP0", "map_id": "Q9VHP0", "name": "bel", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263231", "map_id": "FBgn0263231", "name": "bel", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JY94", "map_id": "Q7JY94", "name": "Atg7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034366", "map_id": "FBgn0034366", "name": "Atg7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VY39", "map_id": "Q9VY39", "name": "anon-WO0140519.10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030562", "map_id": "FBgn0030562", "name": "anon-WO0140519.10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T3W8", "map_id": "Q8T3W8", "name": "scpr-C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037879", "map_id": "FBgn0037879", "name": "scpr-C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VT82", "map_id": "Q9VT82", "name": "Dmel\\CG8072", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036070", "map_id": "FBgn0036070", "name": "Dmel\\CG8072", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VY19", "map_id": "Q9VY19", "name": "Ag5r2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": 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"map_id": "FBgn0034624", "name": "Dmel\\CG17974", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IND6", "map_id": "Q8IND6", "name": "NEST:bs01d08", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051296", "map_id": "FBgn0051296", "name": "NEST:bs01d08", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGQ3", "map_id": "Q9VGQ3", "name": "scpr-A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037889", "map_id": "FBgn0037889", "name": "scpr-A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VT84", "map_id": "Q9VT84", "name": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"none" }, { "id": "Q9VSB3", "map_id": "Q9VSB3", "name": "CG13682", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052365", "map_id": "FBgn0052365", "name": "CG13682", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PCP3", "map_id": "M9PCP3", "name": "mdcds_8484", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031752", "map_id": "FBgn0031752", "name": "mdcds_8484", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7U2", "map_id": "A1Z7U2", "name": "Dmel\\CG8800", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": 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"FBgn0003889", "name": "betaTub85D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P08841", "map_id": "P08841", "name": "betaTub60D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003888", "map_id": "FBgn0003888", "name": "betaTub60D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q5BIL9", "map_id": "Q5BIL9", "name": "Dmel\\CG18278", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V4M2", "map_id": "Q9V4M2", "name": "wech", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259745", "map_id": "FBgn0259745", "name": "wech", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA41", "map_id": "Q9VA41", "name": "Npc2h", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039801", "map_id": "FBgn0039801", "name": "Npc2h", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFN7", "map_id": "Q9VFN7", "name": "Npc2b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038198", "map_id": "FBgn0038198", "name": "Npc2b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH33", "map_id": "Q9VH33", "name": "Npc2e", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051410", "map_id": "FBgn0051410", "name": "Npc2e", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCC8", "map_id": "Q9VCC8", "name": "Npc2f", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039154", "map_id": "FBgn0039154", "name": "Npc2f", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH32", "map_id": "Q9VH32", "name": "Npc2d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037782", "map_id": "FBgn0037782", "name": "Npc2d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA42", "map_id": "Q9VA42", "name": "Npc2g", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039800", "map_id": "FBgn0039800", "name": "Npc2g", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH31", "map_id": "Q9VH31", "name": "Npc2c", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037783", "map_id": "FBgn0037783", "name": "Npc2c", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQ62", "map_id": "Q9VQ62", "name": "Npc2a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031381", "map_id": "FBgn0031381", "name": "Npc2a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ58", "map_id": "Q9VJ58", "name": "Faf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025608", "map_id": "FBgn0025608", "name": "Faf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHA8", "map_id": "Q9VHA8", "name": "phospho-P58IPK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037718", "map_id": "FBgn0037718", "name": "phospho-P58IPK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPX6", "map_id": "Q9VPX6", "name": "capt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261458", "map_id": "FBgn0261458", "name": "capt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10484240", "map_id": "none", "name": "Azurophil granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10482369", "map_id": "none", "name": "Exocytosis of tertiary granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen" }, { "id": "species_10482267", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800173", "compartment_display": "tertiary granule lumen", "complex": "true" }, { "id": "Q9VTP0", "map_id": "Q9VTP0", "name": "CT18701", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259140", "map_id": "FBgn0259140", "name": "CT18701", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZF0", "map_id": "Q9XZF0", "name": "Yippee", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026749", "map_id": "FBgn0026749", "name": "Yippee", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10482367", "map_id": "none", "name": "Tertiary granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10485728", "map_id": "none", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10485646", "map_id": "none", "name": "Ficolin-rich granule lumen proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800405", "compartment_display": "ficolin-1-rich granule lumen", "complex": "true" }, { "id": "Q95RX5", "map_id": "Q95RX5", "name": "Kcmf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037655", "map_id": "FBgn0037655", "name": "Kcmf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXH6", "map_id": "Q9VXH6", "name": "CalpC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260450", "map_id": "FBgn0260450", "name": "CalpC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VY87", "map_id": "Q9VY87", "name": "CtsB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030521", "map_id": "FBgn0030521", "name": "CtsB", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7W2", "map_id": "Q9I7W2", "name": "Dmel\\CG12106", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030100", "map_id": "FBgn0030100", "name": "Dmel\\CG12106", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4J4", "map_id": "Q9W4J4", "name": "Dmel\\CG11444", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029715", "map_id": "FBgn0029715", "name": "Dmel\\CG11444", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485726", "map_id": "none", "name": "Ficolin-rich granule lumen proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10485200", "map_id": "none", "name": "Exocytosis of ficolin-rich granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane" }, { "id": "species_10485116", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_6800424", "compartment_display": "ficolin-1-rich granule membrane", "complex": "true" }, { "id": "Q9VHM2", "map_id": "Q9VHM2", "name": "C16orf62", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037622", "map_id": "FBgn0037622", "name": "C16orf62", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPV8", "map_id": "Q9VPV8", "name": "IA-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031294", "map_id": "FBgn0031294", "name": "IA-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPU6", "map_id": "Q9VPU6", "name": "phospho-Dmel\\CG13950", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031289", "map_id": "FBgn0031289", "name": "phospho-Dmel\\CG13950", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEX6", "map_id": "Q9VEX6", "name": "bor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0287225", "map_id": "FBgn0287225", "name": "bor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485198", "map_id": "none", "name": "Ficolin-rich granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10482080", "map_id": "none", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10481912", "map_id": "none", "name": "Secretory granule membrane proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_216813", "compartment_display": "secretory granule membrane", "complex": "true" }, { "id": "Q9VPH1", "map_id": "Q9VPH1", "name": "Toll-9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036978", "map_id": "FBgn0036978", "name": "Toll-9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KRW4", "map_id": "Q7KRW4", "name": "superdeath", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039640", "map_id": "FBgn0039640", "name": "superdeath", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W5Y0", "map_id": "Q9W5Y0", "name": "Nep3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10482078", "map_id": "none", "name": "Secretory granule membrane proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10493472", "map_id": "none", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493467", "map_id": "Q9VL16", "name": "Dmel\\CG5676", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "FBgn0032200", "map_id": "FBgn0032200", "name": "phospho-Dmel\\CG5676", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493470", "map_id": "Q9VL16", "name": "phospho-Dmel\\CG5676", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10493490", "map_id": "none", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493487", "map_id": "Q9VL16", "name": "phospho-Dmel\\CG5676", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10493476", "map_id": "none", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10475486", "map_id": "Q8MQJ7", "name": "Atg1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10493474", "map_id": "Q8MQJ7", "name": "Atg1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10493496", "map_id": "none", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10493493", "map_id": "Q9VL16", "name": "phospho-Dmel\\CG5676", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10493484", "map_id": "none", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493481", "map_id": "O46084", "name": "Pgam5", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "FBgn0023517", "map_id": "FBgn0023517", "name": "Pgam5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470847", "map_id": "none", "name": "Parkin promotes the ubiquitination of mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10457377", "map_id": "none", "name": "Homologues of MFN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10457379", "map_id": "Q7YU24", "name": "Marf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10470844", "map_id": "Q9VPD5", "name": "mTerf3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "FBgn0037008", "map_id": "FBgn0037008", "name": "mTerf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470752", "map_id": "none", "name": "Homologues of K48polyUb-MFN2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10470784", "map_id": "none", "name": "Homologues of K48polyUb-VDAC1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "species_10470758", "map_id": "Q9VPD5", "name": "mTerf3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10470745", "map_id": "Q7YU24", "name": "Marf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "species_10470798", "map_id": "none", "name": "PARK2:PINK1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q0KHV6", "map_id": "Q0KHV6", "name": "Pink1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029891", "map_id": "FBgn0029891", "name": "Pink1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTX7", "map_id": "Q7KTX7", "name": "park", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470828", "map_id": "none", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10470789", "map_id": "P14199", "name": "ref(2)P", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0003231", "map_id": "FBgn0003231", "name": "ref(2)P", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470791", "map_id": "none", "name": "K48polyUB Mitophagy Substrates:SQSTM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "Q9VPD5", "map_id": "Q9VPD5", "name": "mTerf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P14199", "map_id": "P14199", "name": "ref(2)P", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470826", "map_id": "none", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "species_10470804", "map_id": "Q0KHV6", "name": "Pink1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10470796", "map_id": "Q0KHV6", "name": "Pink1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10470824", "map_id": "none", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle" }, { "id": "species_10470816", "map_id": "none", "name": "ATG5:ATG12", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "Q9W3R7", "map_id": "Q9W3R7", "name": "Atg5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029943", "map_id": "FBgn0029943", "name": "Atg5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTU1", "map_id": "Q9VTU1", "name": "Atg12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036255", "map_id": "FBgn0036255", "name": "Atg12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470820", "map_id": "none", "name": "LC3:K48polyUB Mitophagy Substrates:SQSTM1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10470822", "map_id": "none", "name": "ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_21994", "compartment_display": "phagocytic vesicle", "complex": "true" }, { "id": "reaction_10470832", "map_id": "none", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_10470830", "map_id": "Q0KHV6", "name": "Pink1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "reaction_10470800", "map_id": "none", "name": "Pink1 recruits Parkin to the outer mitochondrial membrane.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane" }, { "id": "reaction_10498066", "map_id": "none", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498064", "map_id": "none", "name": "PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q400N2", "map_id": "Q400N2", "name": "Plp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086690", "map_id": "FBgn0086690", "name": "Plp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA37", "map_id": "Q9VA37", "name": "dj-1beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039802", "map_id": "FBgn0039802", "name": "dj-1beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10498062", "map_id": "none", "name": "PolyUb-Misfolded Proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10498041", "map_id": "none", "name": "UBE2N:UBE2V1:PRKN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498039", "map_id": "none", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498013", "map_id": "none", "name": "Ub:UBE2N:UBE2V1:PRKN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10498035", "map_id": "none", "name": "Misfolded Proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10498037", "map_id": "none", "name": "Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498122", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498118", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "M9PJN5", "map_id": "M9PJN5", "name": "HDAC6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026428", "map_id": "FBgn0026428", "name": "HDAC6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10473486", "map_id": "none", "name": "Dynein complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10498120", "map_id": "none", "name": "PolyUb-Misfolded Proteins:HDAC6:Dynein complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498091", "map_id": "none", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498089", "map_id": "none", "name": "Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498093", "map_id": "none", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10498015", "map_id": "none", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10498011", "map_id": "none", "name": "Ub:UBE2N:UBE2V1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476379", "map_id": "none", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476267", "map_id": "none", "name": "LC3:CysO263-ATG3:ATG7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VVS6", "map_id": "Q9VVS6", "name": "Atg3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036813", "map_id": "FBgn0036813", "name": "Atg3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEG5", "map_id": "Q9VEG5", "name": "Atg8b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038539", "map_id": "FBgn0038539", "name": "Atg8b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476252", "map_id": "none", "name": "ATG7 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10476207", "map_id": "none", "name": "CysO263-ATG3:LC3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476250", "map_id": "none", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10460755", "map_id": "none", "name": "BECN1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VAP6", "map_id": "Q9VAP6", "name": "Atg14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039636", "map_id": "FBgn0039636", "name": "Atg14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476237", "map_id": "none", "name": "Beclin-1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10476377", "map_id": "none", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476211", "map_id": "Q9VVS6", "name": "Atg3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10476263", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10476265", "map_id": "none", "name": "LC3:CysO572-ATG7:ATG7:ATG3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476248", "map_id": "none", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476225", "map_id": "none", "name": "ATG16L1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "B7Z0R7", "map_id": "B7Z0R7", "name": "Atg16", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039705", "map_id": "FBgn0039705", "name": "Atg16", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476227", "map_id": "none", "name": "WIPI2:PI(3,5)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "M9PER1", "map_id": "M9PER1", "name": "Atg18a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035850", "map_id": "FBgn0035850", "name": "Atg18a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476229", "map_id": "none", "name": "ATG16L1 complex:WIPI2:PI(3,5)P2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "reaction_10476246", "map_id": "none", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476100", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VHR6", "map_id": "Q9VHR6", "name": "Atg13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261108", "map_id": "FBgn0261108", "name": "Atg13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MQJ7", "map_id": "Q8MQJ7", "name": "Atg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWQ1", "map_id": "Q9VWQ1", "name": "Atg101", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030960", "map_id": "FBgn0030960", "name": "Atg101", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7KTS2", "map_id": "Q7KTS2", "name": "Atg17", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037363", "map_id": "FBgn0037363", "name": "Atg17", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460794", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10476244", "map_id": "none", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476241", "map_id": "none", "name": "MTMR3,MTMR14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475727", "map_id": "none", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475494", "map_id": "none", "name": "ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10475696", "map_id": "none", "name": "MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10476239", "map_id": "none", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475715", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10475724", "map_id": "none", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10475722", "map_id": "none", "name": "TSC1:p-S1387-TSC2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476299", "map_id": "none", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476199", "map_id": "none", "name": "LC3 family", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476297", "map_id": "none", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476278", "map_id": "none", "name": "LC3 family precursors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10476294", "map_id": "none", "name": "ATG4", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VPW2", "map_id": "Q9VPW2", "name": "Atg4a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031298", "map_id": "FBgn0031298", "name": "Atg4a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476232", "map_id": "none", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5681998", "map_id": "CHEBI:16038", "name": "PE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10476209", "map_id": "none", "name": "LC3:PE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "reaction_10476103", "map_id": "none", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475691", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475718", "map_id": "none", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10460797", "map_id": "none", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10460757", "map_id": "none", "name": "AMBRA1:DYNLL1,DYNLL2:BECN1 complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10460763", "map_id": "none", "name": "BECN1 complex:p-AMBRA1:DYNLL1,DYNLL2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475708", "map_id": "none", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475496", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476091", "map_id": "none", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10475946", "map_id": "none", "name": "MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "species_10475701", "map_id": "none", "name": "p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476347", "map_id": "none", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane" }, { "id": "species_10476338", "map_id": "none", "name": "LC3:PE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5683628", "compartment_display": "autophagosome membrane", "complex": "true" }, { "id": "species_10476345", "map_id": "none", "name": "UVRAG complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VK07", "map_id": "Q9VK07", "name": "Uvrag", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032499", "map_id": "FBgn0032499", "name": "Uvrag", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10475706", "map_id": "none", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane" }, { "id": "species_10475703", "map_id": "none", "name": "MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10476407", "map_id": "none", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475505", "map_id": "none", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475502", "map_id": "none", "name": "p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10475694", "map_id": "none", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10476270", "map_id": "none", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475948", "map_id": "none", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10496854", "map_id": "none", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476254", "map_id": "none", "name": "ATG12:ATG7 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10476375", "map_id": "none", "name": "ATG12:ATG7:CysO572-ATG7", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476328", "map_id": "none", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10476326", "map_id": "none", "name": "ATG14:PIK3C3:PIK3R4:p-S15-BECN1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "reaction_10476322", "map_id": "none", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10476128", "map_id": "none", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5693050", "map_id": "CHEBI:17283", "name": "PI3P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "false" }, { "id": "species_10476124", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VIE1", "map_id": "Q9VIE1", "name": "Atg18b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032935", "map_id": "FBgn0032935", "name": "Atg18b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10476126", "map_id": "none", "name": "WIPI1,WIPI2,(WDR45,WDR45B):PI3P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5679192", "compartment_display": "phagophore assembly site membrane", "complex": "true" }, { "id": "reaction_10476256", "map_id": "none", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10476218", "map_id": "Q9VTU1", "name": "Atg12", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_350436", "map_id": "none", "name": "DGO binds to DSH", "reversible": "false", "notes": "Diego (DGO) binding to Dishevelled (DSH) enhances Frizzled (FZ) PCP signalling. DGO, like FZ is required in R3/Distal cell fate. DGO binds to PDZ domain of DSH. DGO binding to DSH protects it from (Prickle) PK binding and its antagonistic effects. DGO could help promote DSH activation via stimulation of its phosphorylation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450795", "map_id": "none", "name": "PK:VANG:STAN dimer:FZ:DSH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_351073", "map_id": "Q7JUF2", "name": "DGO", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_350486", "map_id": "none", "name": "DSH binds to FZ at the plasma membrane", "reversible": "false", "notes": "In the cytosol, the PDZ domain of Dishevelled (DSH) binds to the transmembrane receptor Frizzled (FZ) at the plasma membrane.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450698", "map_id": "none", "name": "VANG:STAN dimer:FZ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_450779", "map_id": "none", "name": "VANG:STAN dimer:FZ:DSH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_350408", "map_id": "none", "name": "PK binds to VANG at the plasma membrane", "reversible": "false", "notes": "C-terminal region of Vang Gogh (VANG) binds to a C-terminal region of Prickle (PK). Both VANG and PK are both able to bind to themselves in the same regions.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351050", "map_id": "A1Z6W3", "name": "PK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10493702", "map_id": "none", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10493700", "map_id": "none", "name": "RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_390133", "map_id": "none", "name": "YKI transports from the cytosol to the nucleus", "reversible": "false", "notes": "The transcription factor Yorkie (YKI) translocates from the cytosol to the nucleus.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_390143", "map_id": "Q45VV3", "name": "YKI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_390184", "map_id": "none", "name": "YKI binds to SD and activates transcription", "reversible": "false", "notes": "The transcriptional factor Yorkie (YKI) forms a transcriptional activation complex for its target genes with Scalloped (SD).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_390187", "map_id": "P30052", "name": "SD", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_390092", "map_id": "none", "name": "YKI:SD", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_451819", "map_id": "none", "name": "YKI binds to HTH and TSH and activates transcription", "reversible": "false", "notes": "Yorkie (YKI) binds to the DNA-binding transcription factor, Homothorax (HTH). HTH in conjunction with the DNA-binding transcription factor, Teashirt (TSH) regulate the YKI target gene for the microRNA bantam (ban). HTH and YKI are both bound to the same region of the bantam locus in eye discs. This suggests that YKI, HTH, and TSH form a DNA-binding complex which activates transcription for the bantam target gene.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_451881", "map_id": "O46339", "name": "HTH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_451832", "map_id": "P22265", "name": "TSH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_451887", "map_id": "none", "name": "HTH:YKI:TSH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P22265", "map_id": "P22265", "name": "TSH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "TSH", "map_id": "TSH", "name": "TSH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O46339", "map_id": "O46339", "name": "HTH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "HTH", "map_id": "HTH", "name": "HTH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10436586", "map_id": "none", "name": "Association of mTERF with the termination sequence", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_164569", "map_id": "none", "name": "mitochondrial transcription termination sequence", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10436582", "map_id": "Q9V3F3", "name": "mTTF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0028530", "map_id": "FBgn0028530", "name": "mTTF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10436584", "map_id": "none", "name": "mTERF:mitochondrial transcription termination sequence", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9V3F3", "map_id": "Q9V3F3", "name": "mTTF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432638", "map_id": "none", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432467", "map_id": "none", "name": "pol II closed pre-initiation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432479", "map_id": "none", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432427", "map_id": "none", "name": "pol II transcription complex containing 3 Nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10431322", "map_id": "P29052", "name": "TfIIB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10432477", "map_id": "none", "name": "pol II transcription complex containing 4 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10429256", "map_id": "none", "name": "RNA Polymerase II (unphosphorylated):TFIIF complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432430", "map_id": "none", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10432494", "map_id": "none", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10431432", "map_id": "none", "name": "TFIIE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10432492", "map_id": "none", "name": "pol II transcription complex containing 9 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434104", "map_id": "none", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433060", "map_id": "none", "name": "pol II transcription complex containing 11 nucleotide long transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497528", "map_id": "none", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10433062", "map_id": "none", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10497530", "map_id": "none", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10434782", "map_id": "none", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434780", "map_id": "none", "name": "Processive elongation complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434796", "map_id": "none", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434792", "map_id": "none", "name": "Elongation complex prior to separation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10434794", "map_id": "none", "name": "Elongation complex with separated and uncleaved transcript", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434818", "map_id": "none", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10492379", "map_id": "none", "name": "SERPINB13 binds cathepsin L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10492375", "map_id": "none", "name": "Cathepsin L", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10492373", "map_id": "none", "name": "Homologues of SERPINB13", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10492377", "map_id": "none", "name": "SERPINB13:cathepsin L", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10492383", "map_id": "none", "name": "SERPINB13 binds CTSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10465003", "map_id": "none", "name": "Homologues of CTSK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10492381", "map_id": "none", "name": "CTSK:SERPINB13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "reaction_10492387", "map_id": "none", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467716", "map_id": "none", "name": "SWI/SNF chromatin remodelling complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VKJ1", "map_id": "Q9VKJ1", "name": "SMARCC1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032348", "map_id": "FBgn0032348", "name": "SMARCC1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VF03", "map_id": "Q9VF03", "name": "mor", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0002783", "map_id": "FBgn0002783", "name": "mor", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24090", "map_id": "Q24090", "name": "Snr1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0011715", "map_id": "FBgn0011715", "name": "Snr1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10492385", "map_id": "none", "name": "RUNX1:CBFB:SWI/SNF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10491720", "map_id": "none", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491687", "map_id": "none", "name": "RUNX1:CBFB:EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10491717", "map_id": "none", "name": "p-S249,S273,T276-RUNX1:CBFB:p-S,T-EP300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10469635", "map_id": "Q9W0Q1", "name": "Hipk", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10491722", "map_id": "none", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10491715", "map_id": "none", "name": "p-S249,S273,T276-RUNX1:CBFB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492299", "map_id": "none", "name": "RUNX1 binds PRC1 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492295", "map_id": "none", "name": "(PRC1.4,PRC1.5)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10492297", "map_id": "none", "name": "RUNX1:CBFB:(PRC1.4,PRC1.5)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10491724", "map_id": "none", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10492446", "map_id": "none", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492442", "map_id": "P11536", "name": "Eip74EF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0000567", "map_id": "FBgn0000567", "name": "Eip74EF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10492444", "map_id": "none", "name": "RUNX1:CBFB:ELF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P11536", "map_id": "P11536", "name": "Eip74EF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10492480", "map_id": "none", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492476", "map_id": "none", "name": "Homologues of PAX5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O16117", "map_id": "O16117", "name": "sv", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005561", "map_id": "FBgn0005561", "name": "sv", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O18381", "map_id": "O18381", "name": "ey", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005558", "map_id": "FBgn0005558", "name": "ey", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P23758", "map_id": "P23758", "name": "Poxn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003130", "map_id": "FBgn0003130", "name": "Poxn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10492478", "map_id": "none", "name": "RUNX1:CBFB:PAX5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492459", "map_id": "none", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10492455", "map_id": "none", "name": "Homologues of ELF2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q01842", "map_id": "Q01842", "name": "aop", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000097", "map_id": "FBgn0000097", "name": "aop", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10492457", "map_id": "none", "name": "RUNX1:CBFB:ELF2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10494980", "map_id": "none", "name": "E2F6:TFDP1 binds to MGA:MAX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10494970", "map_id": "none", "name": "E2F6:TFDP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10494976", "map_id": "none", "name": "MGA:MAX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P91664", "map_id": "P91664", "name": "Max", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0017578", "map_id": "FBgn0017578", "name": "Max", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10494978", "map_id": "none", "name": "E2F6:TFDP1:MGA:MAX", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495062", "map_id": "none", "name": "E2F6 binds the PRC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495049", "map_id": "none", "name": "E2F6:(TFDP1,TFDP2)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10495058", "map_id": "none", "name": "PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W215", "map_id": "Q9W215", "name": "RYBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034763", "map_id": "FBgn0034763", "name": "RYBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495060", "map_id": "none", "name": "E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495047", "map_id": "none", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10494968", "map_id": "Q27368", "name": "E2f1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10457961", "map_id": "Q24318", "name": "Dp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10495045", "map_id": "none", "name": "E2F6:TFDP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10494984", "map_id": "none", "name": "EHMT1:EHMT2 complex binds E2F6.com-1 core", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10494982", "map_id": "none", "name": "E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495850", "map_id": "none", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495848", "map_id": "Q27368", "name": "phospho-E2f1", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10494972", "map_id": "none", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10457959", "map_id": "Q24318", "name": "Dp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10495839", "map_id": "none", "name": "CBX3 and PRC1.6 associate with E2F6.com-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495835", "map_id": "none", "name": "PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VK33", "map_id": "Q9VK33", "name": "Sfmbt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495829", "map_id": "Q9VCU6", "name": "HP1c", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10495837", "map_id": "none", "name": "E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10492290", "map_id": "none", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10492282", "map_id": "none", "name": "MyrG-p-Y419-SRC:RUNX3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10492287", "map_id": "M9PI08", "name": "phospho-RunxA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10492292", "map_id": "none", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10492280", "map_id": "M9PI08", "name": "RunxA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10494821", "map_id": "none", "name": "SMURFs ubiquitinate RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10494816", "map_id": "M9PI08", "name": "RunxA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10494818", "map_id": "Q9V853", "name": "Smurf", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10492284", "map_id": "none", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10494812", "map_id": "none", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10494808", "map_id": "M9PI08", "name": "RunxA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10494810", "map_id": "M9PI08", "name": "RunxA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10489805", "map_id": "none", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10494814", "map_id": "none", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10493669", "map_id": "none", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10493667", "map_id": "none", "name": "RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10445384", "map_id": "none", "name": "Formation of NR-MED1 Coactivator Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10445375", "map_id": "none", "name": "NR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P13054", "map_id": "P13054", "name": "knrl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001323", "map_id": "FBgn0001323", "name": "knrl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P16376", "map_id": "P16376", "name": "svp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003651", "map_id": "FBgn0003651", "name": "svp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q05192", "map_id": "Q05192", "name": "Hr39", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261239", "map_id": "FBgn0261239", "name": "Hr39", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P33244", "map_id": "P33244", "name": "ftz-f1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24142", "map_id": "Q24142", "name": "Hr78", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015239", "map_id": "FBgn0015239", "name": "Hr78", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49866", "map_id": "P49866", "name": "Hnf4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004914", "map_id": "FBgn0004914", "name": "Hnf4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49869", "map_id": "P49869", "name": "phospho-Hr38", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZA01", "map_id": "A1ZA01", "name": "Hr51", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034012", "map_id": "FBgn0034012", "name": "Hr51", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P18102", "map_id": "P18102", "name": "tll", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003720", "map_id": "FBgn0003720", "name": "tll", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y0Y6", "map_id": "Q9Y0Y6", "name": "Madm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027497", "map_id": "FBgn0027497", "name": "Madm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JHX0", "map_id": "E1JHX0", "name": "Dmel\\CG42554", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260756", "map_id": "FBgn0260756", "name": "Dmel\\CG42554", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445382", "map_id": "none", "name": "NR-MED1 Coactivator Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10488872", "map_id": "none", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10488868", "map_id": "none", "name": "CTNNB1:TCF7L2,LEF1:CCND1 Gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10488864", "map_id": "Q04787", "name": "bsh", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0000529", "map_id": "FBgn0000529", "name": "bsh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488870", "map_id": "none", "name": "VENTX:TCF4,LEF1:CCND1 Gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q04787", "map_id": "Q04787", "name": "bsh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10490422", "map_id": "none", "name": "DEK binds TFAP2A homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10490418", "map_id": "Q8T0D3", "name": "Dek", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0026533", "map_id": "FBgn0026533", "name": "Dek", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10490420", "map_id": "none", "name": "DEK:TFAP2A homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8T0D3", "map_id": "Q8T0D3", "name": "Dek", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489712", "map_id": "none", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489702", "map_id": "M9PIH9", "name": "TfAP-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10489731", "map_id": "none", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10489725", "map_id": "M9PIH9", "name": "TfAP-2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467863", "map_id": "M9PIH9", "name": "TfAP-2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10489727", "map_id": "none", "name": "TFAP2C:WWOX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10489743", "map_id": "none", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489739", "map_id": "none", "name": "TFAP2B homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10489737", "map_id": "Q9VM63", "name": "Gas41", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0031873", "map_id": "FBgn0031873", "name": "Gas41", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489741", "map_id": "none", "name": "TFAP2B homodimer:YEATS4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VM63", "map_id": "Q9VM63", "name": "Gas41", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489729", "map_id": "none", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10489721", "map_id": "none", "name": "KCTD1 binds TFAP2 homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10489717", "map_id": "D5SHR0", "name": "twz", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0034636", "map_id": "FBgn0034636", "name": "twz", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489719", "map_id": "none", "name": "TFAP2 homo- and heterodimers:KCTD1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "D5SHR0", "map_id": "D5SHR0", "name": "twz", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489769", "map_id": "none", "name": "TFAP2C homodimer binds MYC and KDM5B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467865", "map_id": "none", "name": "TFAP2C homodimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10489765", "map_id": "Q9VMJ7", "name": "lid", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0031759", "map_id": "FBgn0031759", "name": "lid", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489760", "map_id": "Q9W4S7", "name": "Myc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0262656", "map_id": "FBgn0262656", "name": "Myc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489767", "map_id": "none", "name": "TFAP2C homodimer:MYC:KDM5B", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9W4S7", "map_id": "Q9W4S7", "name": "Myc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VMJ7", "map_id": "Q9VMJ7", "name": "lid", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497665", "map_id": "none", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497660", "map_id": "Q95V55", "name": "foxo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10497662", "map_id": "none", "name": "KAT2B,(EP300)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497764", "map_id": "none", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497762", "map_id": "none", "name": "FOXO1:CREBBP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10497672", "map_id": "none", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_427498", "map_id": "CHEBI:76279", "name": "2'-O-acetyl-ADP-ribose", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10497669", "map_id": "none", "name": "SIRT1,SIRT3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VK34", "map_id": "Q9VK34", "name": "Sirt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024291", "map_id": "FBgn0024291", "name": "Sirt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497573", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497569", "map_id": "none", "name": "YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10497571", "map_id": "none", "name": "p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497579", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497575", "map_id": "none", "name": "YWHAZ dimer,YWHAQ dimer,SFN dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10497577", "map_id": "none", "name": "p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497567", "map_id": "none", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10497583", "map_id": "none", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10497565", "map_id": "Q95V55", "name": "phospho-foxo", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10497581", "map_id": "none", "name": "p-T32,S197,S262-FOXO4:YWHAZ dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10497637", "map_id": "none", "name": "FOXG1 binds FOXO:SMAD complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497628", "map_id": "none", "name": "FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10497633", "map_id": "P32031", "name": "slp2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0004567", "map_id": "FBgn0004567", "name": "slp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10497635", "map_id": "none", "name": "FOXG1:FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P32031", "map_id": "P32031", "name": "slp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10497626", "map_id": "none", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10497624", "map_id": "none", "name": "FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434814", "map_id": "none", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10434808", "map_id": "none", "name": "Formation of NELF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434644", "map_id": "P92204", "name": "Nelf-E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10434629", "map_id": "Q86NP2", "name": "Nelf-A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10434634", "map_id": "Q9Y113", "name": "NELF-B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10434639", "map_id": "Q24134", "name": "TH1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434806", "map_id": "none", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434710", "map_id": "none", "name": "Elongin B:C complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10434715", "map_id": "Q9VCP0", "name": "EloA", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10432469", "map_id": "none", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10434804", "map_id": "none", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434708", "map_id": "O44226", "name": "EloB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10434703", "map_id": "Q7JWD6", "name": "EloC", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434802", "map_id": "none", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434651", "map_id": "Q9TVQ5", "name": "spt4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434800", "map_id": "none", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434608", "map_id": "O17432", "name": "Cdk9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10434622", "map_id": "none", "name": "CCNT1,CCNT2,CCNK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10434624", "map_id": "none", "name": "P-TEFb complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434798", "map_id": "none", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434691", "map_id": "Q05344", "name": "Ssrp", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10434696", "map_id": "Q8IRG6", "name": "dre4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10431436", "map_id": "none", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_109877", "map_id": "none", "name": "template DNA with first transcript dinucleotide, opened to +8 position", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10432457", "map_id": "none", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432455", "map_id": "none", "name": "Pol II Promoter Escape Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_110068", "map_id": "none", "name": "DNA containing Pol II promoter with transcript with 2 or 3 nucleotides", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434822", "map_id": "none", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10434790", "map_id": "none", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434788", "map_id": "none", "name": "Aborted elongation complex after arrest", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432613", "map_id": "none", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432611", "map_id": "none", "name": "pol II transcription complex containing 4-9 nucleotide long transcript", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_75897", "map_id": "none", "name": "template DNA:4-9 nucleotide transcript hybrid", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10434820", "map_id": "none", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10434786", "map_id": "none", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434784", "map_id": "none", "name": "Paused processive elongation complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10434816", "map_id": "none", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10433419", "map_id": "none", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432082", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF:TFIIE complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433417", "map_id": "none", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432078", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10432080", "map_id": "none", "name": "pol II promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433415", "map_id": "none", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432076", "map_id": "none", "name": "pol II promoter:TFIID complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10433413", "map_id": "none", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_109627", "map_id": "none", "name": "DNA containing RNA Polymerase II promoter", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10432084", "map_id": "none", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10486881", "map_id": "none", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486869", "map_id": "none", "name": "RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VF25", "map_id": "Q9VF25", "name": "Pbp45", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038371", "map_id": "FBgn0038371", "name": "Pbp45", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHX0", "map_id": "Q9VHX0", "name": "Pbp95", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037540", "map_id": "FBgn0037540", "name": "Pbp95", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P31368", "map_id": "P31368", "name": "nub", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085424", "map_id": "FBgn0085424", "name": "nub", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK71", "map_id": "Q9VK71", "name": "pdm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004394", "map_id": "FBgn0004394", "name": "pdm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWY6", "map_id": "Q9VWY6", "name": "Taf8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022724", "map_id": "FBgn0022724", "name": "Taf8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10486878", "map_id": "none", "name": "RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10486883", "map_id": "none", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10486871", "map_id": "none", "name": "Initiation factors:CDK7:snRNA gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10487494", "map_id": "none", "name": "Integrator complex processes the 3' end of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10487478", "map_id": "none", "name": "RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P22293", "map_id": "P22293", "name": "su(sable)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003575", "map_id": "FBgn0003575", "name": "su(sable)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95TS5", "map_id": "Q95TS5", "name": "IntS9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036570", "map_id": "FBgn0036570", "name": "IntS9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7PLS8", "map_id": "Q7PLS8", "name": "IntS3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262117", "map_id": "FBgn0262117", "name": "IntS3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEX5", "map_id": "Q9VEX5", "name": "Asun", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020407", "map_id": "FBgn0020407", "name": "Asun", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPY0", "map_id": "Q9VPY0", "name": "IntS14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031314", "map_id": "FBgn0031314", "name": "IntS14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3E1", "map_id": "Q9W3E1", "name": "IntS4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026679", "map_id": "FBgn0026679", "name": "IntS4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAH9", "map_id": "Q9VAH9", "name": "IntS11", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039691", "map_id": "FBgn0039691", "name": "IntS11", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFS6", "map_id": "Q9VFS6", "name": "omd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038168", "map_id": "FBgn0038168", "name": "omd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W1C5", "map_id": "Q9W1C5", "name": "IntS1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034964", "map_id": "FBgn0034964", "name": "IntS1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VM17", "map_id": "Q9VM17", "name": "NABP2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031909", "map_id": "FBgn0031909", "name": "NABP2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W485", "map_id": "Q9W485", "name": "IntS6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261383", "map_id": "FBgn0261383", "name": "IntS6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZM7", "map_id": "Q9VZM7", "name": "IntS10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035462", "map_id": "FBgn0035462", "name": "IntS10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VT41", "map_id": "Q9VT41", "name": "defl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036038", "map_id": "FBgn0036038", "name": "defl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBB3", "map_id": "Q9VBB3", "name": "IntS12", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039459", "map_id": "FBgn0039459", "name": "IntS12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAK1", "map_id": "A1ZAK1", "name": "IntS8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025830", "map_id": "FBgn0025830", "name": "IntS8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX31", "map_id": "Q9VX31", "name": "IntS2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030858", "map_id": "FBgn0030858", "name": "IntS2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W039", "map_id": "Q9W039", "name": "Dmel\\CG9018", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035318", "map_id": "FBgn0035318", "name": "Dmel\\CG9018", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2JAA3", "map_id": "X2JAA3", "name": "Dmel\\CG15160", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032688", "map_id": "FBgn0032688", "name": "Dmel\\CG15160", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z7P3", "map_id": "A1Z7P3", "name": "Phax", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033380", "map_id": "FBgn0033380", "name": "Phax", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487486", "map_id": "none", "name": "CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10487480", "map_id": "none", "name": "RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10430034", "map_id": "A1Z9W4", "name": "Pcf11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10487492", "map_id": "Q9VWE4", "name": "Ssu72", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0031054", "map_id": "FBgn0031054", "name": "Ssu72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487465", "map_id": "none", "name": "Pre-snRNA transcript initiation, Integrator binding, LEC binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_29470", "map_id": "CHEBI:17677", "name": "CTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_113562", "map_id": "CHEBI:15713", "name": "UTP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10487441", "map_id": "none", "name": "Integrator", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10487456", "map_id": "none", "name": "LEC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10487360", "map_id": "none", "name": "RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10487462", "map_id": "none", "name": "RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10487501", "map_id": "none", "name": "Pre-snRNA is elongated and capped with 7-methylguanosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10487498", "map_id": "none", "name": "RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10487630", "map_id": "none", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10440022", "map_id": "A1Z7P3", "name": "Phax", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10429515", "map_id": "Q9V9K7", "name": "Ars2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10471026", "map_id": "none", "name": "TDG excises 5-carboxylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5220996", "map_id": "none", "name": "DNA containing 5-caC", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_5221064", "map_id": "CHEBI:76793", "name": "5-caC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10471024", "map_id": "none", "name": "TDG excises 5-formylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_5221062", "map_id": "none", "name": "DNA containing 5-fC", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_5221065", "map_id": "CHEBI:76794", "name": "5-fC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_209227", "map_id": "none", "name": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The Drosophila orthologue of IKKB (IRD5) phosphorylates Relish (REL).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206633", "map_id": "none", "name": "KEY:Phospho IRD5 dimer:KEY", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9GYV5", "map_id": "Q9GYV5", "name": "KEY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "KEY", "map_id": "KEY", "name": "KEY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_214398", "map_id": "none", "name": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The Drosophila orthologue of IKKB (IRD5) phosphorylates Relish (REL).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_209200", "map_id": "none", "name": "HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex", "reversible": "false", "notes": "MAP kinase kinase orthologue, the dual specificity kinase Hemipterous (HEP), is phosphorylated and activated in its activation loop at residues Ser348 and Thr352 by the MAP kinase kinase kinase orthologue, phosphorylated TAK1.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206293", "map_id": "Q23977", "name": "HEP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206922", "map_id": "none", "name": "UEV1A:BEN:IAP2:UBI-P63E:TAB2:Phospho TAK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V3Q6", "map_id": "Q9V3Q6", "name": "TAK1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "TAK1", "map_id": "TAK1", "name": "TAK1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4TZQ4", "map_id": "Q4TZQ4", "name": "TAB2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "TAB2", "map_id": "TAB2", "name": "TAB2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_209188", "map_id": "none", "name": "TAK1-binding protein TAB2 binds to TAK1 kinase", "reversible": "false", "notes": "Areas in the C-terminal part of TAB2 (not the Zinc-finger domain) bind to TAK1 Ser/Thr kinase.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_205754", "map_id": "Q9V3Q6", "name": "TAK1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206059", "map_id": "Q4TZQ4", "name": "TAB2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206731", "map_id": "none", "name": "TAB2:TAK1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209179", "map_id": "none", "name": "IAP2:BEN:UEV1A E3 ligase complex auto-ubiquitinates", "reversible": "false", "notes": "The Apoptosis 2 Inhibitor (IAP2):Bendless (BEN):UEV1A E3 ubiquitin ligase complex autoubiquitinates, forming Lys63-linked ubiquitin chains.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_207030", "map_id": "none", "name": "UEV1A:BEN:IAP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_206608", "map_id": "none", "name": "UEV1A:BEN:IAP2:UBI-P63E", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_205735", "map_id": "Q24307", "name": "IAP2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209289", "map_id": "none", "name": "TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase", "reversible": "false", "notes": "TAB2 in complex with TAK1 kinase binds to the ubiquitin chains emanating from the Apoptosis 2 Inhibitor (IAP2):Bendless (BEN):UEV1A E3 ligase complex. The formation of an E3 ligase:TAB2:TAK1 complex may cause conformational changes to the catalytic domain of TAK1 thus inducing its kinase activity.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206764", "map_id": "none", "name": "UEV1A:BEN:IAP2:UBI-P63E:TAB2:TAK1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209320", "map_id": "none", "name": "Activated TAK1 kinase is autophosphorylated", "reversible": "false", "notes": "TAK1 kinase is phosphorylated at Thr171 by another activated TAK1 kinase in an intermolecular autophosphorylation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_209240", "map_id": "none", "name": "Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5", "reversible": "false", "notes": "IRD5 is phosphorylated and activated by phosphorylated TAK1 kinase at residues Thr217 and Ser221 in the activation loop.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206628", "map_id": "none", "name": "KEY:IRD5 dimer:KEY", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_354273", "map_id": "none", "name": "AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene", "reversible": "false", "notes": "When the JNK pathway is activated, the AP-1 transcription factor, a complex Jun-related antigen (JRA) and Kayak (KAY), forms a complex with the HMG protein, dorsal switch protein (DSP1) and STAT92E transcription factor (involved in the JAK/STAT pathway). This 'repressosome complex' and phosphorylated Relish (REL-68) are mutually exclusive in binding to this gene and so phosphorylated REL-68 is displaced from its target gene.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_354268", "map_id": "Q24537", "name": "DSP1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_354285", "map_id": "none", "name": "Phospho REL-68:PCAF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "O76216", "map_id": "O76216", "name": "PCAF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "PCAF", "map_id": "PCAF", "name": "PCAF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_354283", "map_id": "none", "name": "JRA:KAY:DSP1:STAT92E", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_354287", "map_id": "Q94527", "name": "Phospho REL-68", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_354279", "map_id": "O76216", "name": "PCAF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_354289", "map_id": "none", "name": "AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene", "reversible": "false", "notes": "The 'repressosome complex' recruits the histone deacetylase RPD3 aka HDAC1 to the Relish target gene resulting in repression of its transcription. This is an example of the JNK pathway downregulating the Imd pathway.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_354293", "map_id": "Q94517", "name": "RPD3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_354291", "map_id": "none", "name": "RPD3:JRA:KAY:DSP1:STAT92E", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_209257", "map_id": "none", "name": "Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription", "reversible": "false", "notes": "In the nucleus, phosphorylated Relish (REL-68) forms a complex with the histone acetyltransferase, PCAF, at its target gene and transcription is activated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_209309", "map_id": "none", "name": "Phosphorylated REL-68 transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated N-terminal cleaved domain of Relish (REL-68) translocates from the cytosol to the nucleus. The corresponding phosphorylated C-terminal cleaved domain (REL-49) remains in the cytoplasm.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10472558", "map_id": "none", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5490236", "map_id": "none", "name": "AFXBO-NAC,AFNBO-NAC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78580", "map_id": "CHEBI:78580", "name": "CHEBI:78580", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78585", "map_id": "CHEBI:78585", "name": "CHEBI:78585", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5490231", "map_id": "none", "name": "AFXBO-C,AFNBO-C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78583", "map_id": "CHEBI:78583", "name": "CHEBI:78583", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78578", "map_id": "CHEBI:78578", "name": "CHEBI:78578", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10472555", "map_id": "none", "name": "ACY1:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9I7K3", "map_id": "Q9I7K3", "name": "Dmel\\CG6465", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037818", "map_id": "FBgn0037818", "name": "Dmel\\CG6465", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472539", "map_id": "none", "name": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_5490235", "map_id": "none", "name": "AFXBO-CG,AFNBO-CG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:78579", "map_id": "CHEBI:78579", "name": "CHEBI:78579", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78584", "map_id": "CHEBI:78584", "name": "CHEBI:78584", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5490250", "map_id": "none", "name": "AFXBO-C,AFNBO-C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10443761", "map_id": "none", "name": "DPEP1,2,3 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VBG1", "map_id": "Q9VBG1", "name": "Dmel\\CG6154", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039420", "map_id": "FBgn0039420", "name": "Dmel\\CG6154", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2JCU8", "map_id": "X2JCU8", "name": "CG5917", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266100", "map_id": "FBgn0266100", "name": "CG5917", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPG0", "map_id": "Q9VPG0", "name": "Dmel\\CG5282", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036986", "map_id": "FBgn0036986", "name": "Dmel\\CG5282", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ94", "map_id": "Q9VJ94", "name": "CG7198", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261804", "map_id": "FBgn0261804", "name": "CG7198", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10472537", "map_id": "none", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5423723", "map_id": "none", "name": "AFXBO,AFNBO", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:30725", "map_id": "CHEBI:30725", "name": "CHEBI:30725", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78586", "map_id": "CHEBI:78586", "name": "CHEBI:78586", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_5423730", "map_id": "none", "name": "AFXBO-SG,AFNBO-SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:78581", "map_id": "CHEBI:78581", "name": "CHEBI:78581", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:78587", "map_id": "CHEBI:78587", "name": "CHEBI:78587", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438532", "map_id": "none", "name": "MGST1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10472548", "map_id": "none", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_5490253", "map_id": "none", "name": "AFXBO-SG,AFNBO-SG", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10472545", "map_id": "none", "name": "GGT dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7KUX2", "map_id": "Q7KUX2", "name": "Dmel\\CG4829", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030796", "map_id": "FBgn0030796", "name": "Dmel\\CG4829", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9NFP5", "map_id": "M9NFP5", "name": "Dmel\\CG17636", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025837", "map_id": "FBgn0025837", "name": "Dmel\\CG17636", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYR2", "map_id": "Q9VYR2", "name": "Dmel\\CG1492", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030361", "map_id": "FBgn0030361", "name": "Dmel\\CG1492", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWT3", "map_id": "Q9VWT3", "name": "Ggt-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030932", "map_id": "FBgn0030932", "name": "Ggt-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486816", "map_id": "none", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389843", "map_id": "CHEBI:28938", "name": "NH4+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810070", "map_id": "CHEBI:30744", "name": "OA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10486813", "map_id": "none", "name": "DDO:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10446586", "map_id": "none", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389678", "map_id": "CHEBI:16891", "name": "glyoxylate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389819", "map_id": "CHEBI:16995", "name": "OX", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446580", "map_id": "none", "name": "HAO1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10481081", "map_id": "none", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10478187", "map_id": "Q9U616", "name": "ppl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0027945", "map_id": "FBgn0027945", "name": "ppl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10481070", "map_id": "none", "name": "octanoyl:NDUFAB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "CHEBI:25650", "map_id": "CHEBI:25650", "name": "CHEBI:25650", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10481073", "map_id": "Q9U616", "name": "ppl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10436440", "map_id": "Q94519", "name": "ND-ACP", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10481078", "map_id": "Q9VN27", "name": "LIPT2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0037251", "map_id": "FBgn0037251", "name": "LIPT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10481048", "map_id": "none", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10481032", "map_id": "none", "name": "DHs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VA02", "map_id": "Q9VA02", "name": "lipo-K-DHTKD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039827", "map_id": "FBgn0039827", "name": "lipo-K-DHTKD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10478185", "map_id": "Q9U616", "name": "ppl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10481040", "map_id": "none", "name": "lipoylated DHs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10481045", "map_id": "Q8SX78", "name": "Dmel\\CG44243", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0265178", "map_id": "FBgn0265178", "name": "Dmel\\CG44243", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479511", "map_id": "none", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784236", "map_id": "CHEBI:32812", "name": "4-OH-L-Glu", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6784229", "map_id": "CHEBI:17742", "name": "HOG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10446583", "map_id": "none", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389822", "map_id": "CHEBI:29805", "name": "glycolate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10454421", "map_id": "none", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_159549", "map_id": "CHEBI:57305", "name": "Gly", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10454418", "map_id": "none", "name": "AGXT2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A8E6R2", "map_id": "A8E6R2", "name": "Dmel\\CG11241", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037186", "map_id": "FBgn0037186", "name": "Dmel\\CG11241", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479508", "map_id": "none", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6784241", "map_id": "CHEBI:27391", "name": "1-pyrroline-3-hydroxy-5-carboxylate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10479505", "map_id": "none", "name": "PRODH2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q04499", "map_id": "Q04499", "name": "slgA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003423", "map_id": "FBgn0003423", "name": "slgA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446546", "map_id": "none", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_193446", "map_id": "CHEBI:57305", "name": "Gly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446543", "map_id": "none", "name": "DAO dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10446507", "map_id": "none", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389664", "map_id": "CHEBI:57972", "name": "L-Ala", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389680", "map_id": "CHEBI:15361", "name": "PYR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446504", "map_id": "none", "name": "AGXT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10446571", "map_id": "none", "name": "glyoxylate + NADPH + H+ => glycolate + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10446568", "map_id": "none", "name": "Homologues of GRHPR", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "Q8INU6", "map_id": "Q8INU6", "name": "CG9332", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051674", "map_id": "FBgn0051674", "name": "CG9332", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8I725", "map_id": "Q8I725", "name": "Dmel\\CG1236", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037370", "map_id": "FBgn0037370", "name": "Dmel\\CG1236", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VII9", "map_id": "Q9VII9", "name": "CCG31673", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051673", "map_id": "FBgn0051673", "name": "CCG31673", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SZU0", "map_id": "Q8SZU0", "name": "Dmel\\CG9331", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032889", "map_id": "FBgn0032889", "name": "Dmel\\CG9331", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10481350", "map_id": "none", "name": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5359017", "map_id": "CHEBI:15611", "name": "SARC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10481347", "map_id": "none", "name": "GNMT tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VG42", "map_id": "Q9VG42", "name": "Gnmt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038074", "map_id": "FBgn0038074", "name": "Gnmt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478200", "map_id": "none", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10478189", "map_id": "none", "name": "GCSH:SAMDLL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9U616", "map_id": "Q9U616", "name": "ppl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:14949", "map_id": "CHEBI:14949", "name": "CHEBI:14949", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10478197", "map_id": "none", "name": "PXLP-K754-GLDC dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VH09", "map_id": "Q9VH09", "name": "Dmel\\CG3999", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037801", "map_id": "FBgn0037801", "name": "Dmel\\CG3999", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478215", "map_id": "none", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10478202", "map_id": "none", "name": "GCSH:DHLL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "CHEBI:50746", "map_id": "CHEBI:50746", "name": "CHEBI:50746", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10478212", "map_id": "none", "name": "DLD dimer:2xFAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10478210", "map_id": "none", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10478207", "map_id": "Q9VKR4", "name": "Dmel\\CG6415", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0032287", "map_id": "FBgn0032287", "name": "Dmel\\CG6415", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10481091", "map_id": "none", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6793610", "map_id": "CHEBI:26833", "name": "S", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6793613", "map_id": "CHEBI:17319", "name": "5dAde", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10481088", "map_id": "none", "name": "LIAS:2(4Fe-4S)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q7JQW6", "map_id": "Q7JQW6", "name": "Las", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029158", "map_id": "FBgn0029158", "name": "Las", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428303", "map_id": "none", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113597", "map_id": "CHEBI:16238", "name": "FAD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_113590", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_164934", "map_id": "CHEBI:17877", "name": "FADH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10428300", "map_id": "Q04499", "name": "slgA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10495134", "map_id": "none", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10479501", "map_id": "Q04499", "name": "slgA", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10444090", "map_id": "none", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_353113", "map_id": "CHEBI:15625", "name": "dc-AdoMet", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444087", "map_id": "P91931", "name": "SamDC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0019932", "map_id": "FBgn0019932", "name": "SamDC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444074", "map_id": "none", "name": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444071", "map_id": "X2JGL7", "name": "Sms", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036272", "map_id": "FBgn0036272", "name": "Sms", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444024", "map_id": "none", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444018", "map_id": "none", "name": "Homologues of AZIN1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P40807", "map_id": "P40807", "name": "Odc1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013307", "map_id": "FBgn0013307", "name": "Odc1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P40808", "map_id": "P40808", "name": "Odc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0013308", "map_id": "FBgn0013308", "name": "Odc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444005", "map_id": "none", "name": "ODC:OAZ complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P54361", "map_id": "P54361", "name": "Oda", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014184", "map_id": "FBgn0014184", "name": "Oda", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444022", "map_id": "none", "name": "AZIN1 bound OAZ:ODC complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10444007", "map_id": "none", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10428317", "map_id": "none", "name": "Homologues of PXLP-K69-ODC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10443999", "map_id": "P54361", "name": "Oda", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10444258", "map_id": "none", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10444012", "map_id": "none", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10444009", "map_id": "P40807", "name": "Odc1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10444082", "map_id": "none", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29610", "map_id": "CHEBI:17148", "name": "Putrescine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444079", "map_id": "Q9VHA1", "name": "SpdS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0037723", "map_id": "FBgn0037723", "name": "SpdS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428320", "map_id": "none", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29498", "map_id": "CHEBI:15729", "name": "L-Orn", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10479998", "map_id": "none", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6788606", "map_id": "CHEBI:60175", "name": "5HLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10479995", "map_id": "Q9VJ68", "name": "Dmel\\CG31751", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0086909", "map_id": "FBgn0086909", "name": "Dmel\\CG31751", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428637", "map_id": "none", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70955", "map_id": "CHEBI:15524", "name": "GL-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_71045", "map_id": "CHEBI:15473", "name": "crotonyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428634", "map_id": "none", "name": "GCDH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VMC6", "map_id": "Q9VMC6", "name": "152078_at", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031824", "map_id": "FBgn0031824", "name": "152078_at", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478071", "map_id": "none", "name": "CRYM reduces P2C to PPCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_5693311", "map_id": "CHEBI:16187", "name": "P2C", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_5693325", "map_id": "CHEBI:30913", "name": "PPCA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10478068", "map_id": "Q8SY58", "name": "Dmel\\CG4872", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "FBgn0030799", "map_id": "FBgn0030799", "name": "Dmel\\CG4872", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428486", "map_id": "none", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_30176", "map_id": "CHEBI:16927", "name": "SACN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428480", "map_id": "none", "name": "AASS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VLX0", "map_id": "Q9VLX0", "name": "LKRSDH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286198", "map_id": "FBgn0286198", "name": "LKRSDH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428483", "map_id": "none", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10428627", "map_id": "none", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_70951", "map_id": "CHEBI:15753", "name": "aKADA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10428496", "map_id": "none", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_508531", "map_id": "CHEBI:17082", "name": "2AMA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428493", "map_id": "none", "name": "ALDH7A1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q8SXQ1", "map_id": "Q8SXQ1", "name": "Aldh7A1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036857", "map_id": "FBgn0036857", "name": "Aldh7A1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10444320", "map_id": "none", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_113577", "map_id": "CHEBI:15753", "name": "aKADA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10444317", "map_id": "Q9V3T2", "name": "Dmel\\CG5254", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0040383", "map_id": "FBgn0040383", "name": "Dmel\\CG5254", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10481307", "map_id": "none", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6798162", "map_id": "CHEBI:15354", "name": "Cho", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10481304", "map_id": "Q9VZE7", "name": "Ctl1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "reaction_10481302", "map_id": "none", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6798194", "map_id": "CHEBI:15710", "name": "BETALD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6798202", "map_id": "CHEBI:17750", "name": "BET", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428491", "map_id": "Q8SXQ1", "name": "Aldh7A1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10481299", "map_id": "none", "name": "SARDH:FAD oxidatively demethylates SARC to Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_6797917", "map_id": "CHEBI:15611", "name": "SARC", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_6797920", "map_id": "CHEBI:16842", "name": "CH2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10481296", "map_id": "none", "name": "SARDH:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "A1ZAZ2", "map_id": "A1ZAZ2", "name": "Sardh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034276", "map_id": "FBgn0034276", "name": "Sardh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460684", "map_id": "none", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614532", "map_id": "CHEBI:16136", "name": "H2S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_1614594", "map_id": "CHEBI:62856", "name": "HLAN", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10460713", "map_id": "none", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10460710", "map_id": "none", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10487305", "map_id": "none", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6814151", "map_id": "CHEBI:17141", "name": "2AET", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10487302", "map_id": "none", "name": "ADO:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSD8", "map_id": "Q9VSD8", "name": "Dmel\\CG7550", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035839", "map_id": "FBgn0035839", "name": "Dmel\\CG7550", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487307", "map_id": "none", "name": "PXLP-K333-GADL1 decarboxylates CSA to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787748", "map_id": "CHEBI:16345", "name": "CSA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10460723", "map_id": "none", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10460720", "map_id": "none", "name": "CDO1:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1ZBA8", "map_id": "A1ZBA8", "name": "Dmel\\CG5493", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034364", "map_id": "FBgn0034364", "name": "Dmel\\CG5493", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460690", "map_id": "none", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1614582", "map_id": "CHEBI:21347", "name": "L-Lanthionine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10460671", "map_id": "none", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_1614538", "map_id": "CHEBI:17359", "name": "sulfite(2-)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10460668", "map_id": "none", "name": "holo-SUOX", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VWP4", "map_id": "Q9VWP4", "name": "shop", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030966", "map_id": "FBgn0030966", "name": "shop", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10460708", "map_id": "none", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10460696", "map_id": "Q9VZF6", "name": "Dmel\\CG14997", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0035515", "map_id": "FBgn0035515", "name": "Dmel\\CG14997", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460698", "map_id": "Q9VZF6", "name": "Dmel\\CG14997", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10460705", "map_id": "none", "name": "ETHE1:2Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q86PD3", "map_id": "Q86PD3", "name": "CG30022;CG30023", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050022", "map_id": "FBgn0050022", "name": "CG30022;CG30023", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438434", "map_id": "none", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83909", "map_id": "CHEBI:16335", "name": "Ade-Rib", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438431", "map_id": "none", "name": "AHCY:NAD+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q27580", "map_id": "Q27580", "name": "Ahcy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0014455", "map_id": "FBgn0014455", "name": "Ahcy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495325", "map_id": "none", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5357660", "map_id": "CHEBI:16503", "name": "H2Se", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8959518", "map_id": "CHEBI:16144", "name": "SELP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10495322", "map_id": "O18373", "name": "SelD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0261270", "map_id": "FBgn0261270", "name": "SelD", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428174", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_29514", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428171", "map_id": "none", "name": "ARG1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10428184", "map_id": "none", "name": "argininosuccinate <=> fumarate + arginine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_34575", "map_id": "CHEBI:15682", "name": "ARSUA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10428181", "map_id": "none", "name": "ASL tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VLG9", "map_id": "Q9VLG9", "name": "Argl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032076", "map_id": "FBgn0032076", "name": "Argl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10451632", "map_id": "none", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_374064", "map_id": "CHEBI:32682", "name": "L-Arg", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_374061", "map_id": "CHEBI:16199", "name": "Urea", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10451629", "map_id": "none", "name": "ARG2 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10428272", "map_id": "none", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_113567", "map_id": "CHEBI:16349", "name": "L-Cit", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428269", "map_id": "Q7KVQ8", "name": "Dmel\\CG1628", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0030218", "map_id": "FBgn0030218", "name": "Dmel\\CG1628", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428283", "map_id": "none", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_31339", "map_id": "CHEBI:17232", "name": "L-Glu5S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428280", "map_id": "none", "name": "OAT hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VW26", "map_id": "Q9VW26", "name": "Oat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0022774", "map_id": "FBgn0022774", "name": "Oat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453130", "map_id": "none", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10453127", "map_id": "none", "name": "P5CS dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9VNW6", "map_id": "Q9VNW6", "name": "P5CS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037146", "map_id": "FBgn0037146", "name": "P5CS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479495", "map_id": "none", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_35305", "map_id": "CHEBI:17388", "name": "1PYR-5COOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479492", "map_id": "none", "name": "PYCRL decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VEJ3", "map_id": "Q9VEJ3", "name": "P5cr-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038516", "map_id": "FBgn0038516", "name": "P5cr-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428214", "map_id": "none", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_517496", "map_id": "none", "name": "NAD(P)H", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_517495", "map_id": "none", "name": "NAD(P)+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_10428211", "map_id": "none", "name": "GLUD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10428293", "map_id": "none", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10428290", "map_id": "none", "name": "PYCR1 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10428229", "map_id": "none", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10454402", "map_id": "none", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_893598", "map_id": "CHEBI:30882", "name": "2OGA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10479488", "map_id": "none", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10479485", "map_id": "none", "name": "PYCR2 decamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10428750", "map_id": "none", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_35139", "map_id": "CHEBI:17311", "name": "TMLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_113546", "map_id": "CHEBI:15786", "name": "HTMLYS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10428747", "map_id": "none", "name": "TMLHE:AscH-:Fe2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VDM7", "map_id": "Q9VDM7", "name": "Dmel\\CG4335", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038795", "map_id": "FBgn0038795", "name": "Dmel\\CG4335", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10428761", "map_id": "none", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_31503", "map_id": "CHEBI:15786", "name": "HTMLYS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_31311", "map_id": "CHEBI:18020", "name": "TEABL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10442782", "map_id": "none", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352329", "map_id": "CHEBI:15768", "name": "DIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10442755", "map_id": "Q9VZZ4", "name": "Pxn", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10478122", "map_id": "none", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_351627", "map_id": "CHEBI:16474", "name": "NADPH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351628", "map_id": "CHEBI:18009", "name": "NADP+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10478117", "map_id": "Q9VQH2", "name": "Duox", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0283531", "map_id": "FBgn0283531", "name": "Duox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10442841", "map_id": "none", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352030", "map_id": "CHEBI:58315", "name": "L-Tyr", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10444056", "map_id": "none", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_351630", "map_id": "CHEBI:17606", "name": "I2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10442823", "map_id": "none", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10442839", "map_id": "none", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10442830", "map_id": "none", "name": "DEHAL1:FMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VTE7", "map_id": "Q9VTE7", "name": "Dmel\\CG46439", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036125", "map_id": "FBgn0036125", "name": "Dmel\\CG46439", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10442758", "map_id": "none", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_622410", "map_id": "CHEBI:43451", "name": "HI", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_351639", "map_id": "CHEBI:27847", "name": "MIT", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10442837", "map_id": "none", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_352331", "map_id": "CHEBI:28774", "name": "T3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10442833", "map_id": "none", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10442808", "map_id": "none", "name": "Dopamine is oxidised to noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen" }, { "id": "species_351593", "map_id": "CHEBI:15379", "name": "O2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_351601", "map_id": "CHEBI:18243", "name": "DA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen", "complex": "false" }, { "id": "species_351599", "map_id": "CHEBI:58539", "name": "DeHA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_351603", "map_id": "CHEBI:15377", "name": "H2O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_10442805", "map_id": "none", "name": "DBH tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "true" }, { "id": "Q86B61", "map_id": "Q86B61", "name": "Tbh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010329", "map_id": "FBgn0010329", "name": "Tbh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:18315", "map_id": "CHEBI:18315", "name": "CHEBI:18315", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10442835", "map_id": "none", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_159362", "map_id": "CHEBI:18243", "name": "DA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10442768", "map_id": "none", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442765", "map_id": "none", "name": "TH:Fe2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P18459", "map_id": "P18459", "name": "ple", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005626", "map_id": "FBgn0005626", "name": "ple", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10443240", "map_id": "none", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216621", "map_id": "CHEBI:37248", "name": "3OH-PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216612", "map_id": "CHEBI:63904", "name": "3,16DOH-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10443237", "map_id": "none", "name": "Cytochrome P450 (CYP4F11 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10443235", "map_id": "none", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216620", "map_id": "CHEBI:63998", "name": "19HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10443232", "map_id": "none", "name": "Homologues of CYP2U1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10443248", "map_id": "none", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_216547", "map_id": "CHEBI:16881", "name": "INDOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_216598", "map_id": "CHEBI:31697", "name": "Oxindole", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10443245", "map_id": "none", "name": "Cytochrome P450 (CYP2W1 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10443226", "map_id": "none", "name": "CYP24A1 24-hydroxylates CTL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_215607", "map_id": "CHEBI:17823", "name": "CTL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_215622", "map_id": "CHEBI:63911", "name": "CTLA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10442747", "map_id": "none", "name": "Homologues of CYP24A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "reaction_10442787", "map_id": "none", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8963870", "map_id": "CHEBI:28940", "name": "VD3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_8963879", "map_id": "CHEBI:17933", "name": "25(OH)D", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10442784", "map_id": "Q9VWR5", "name": "phm", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10443163", "map_id": "none", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_266056", "map_id": "CHEBI:15647", "name": "LTB4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161636", "map_id": "CHEBI:15646", "name": "20OH-LTB4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10443160", "map_id": "none", "name": "Cytochrome P450 (CYP4F2/4F3 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10472838", "map_id": "none", "name": "CYP4F22 20-hydroxylates TrXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142713", "map_id": "CHEBI:15630", "name": "TrXA3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5602281", "map_id": "CHEBI:83782", "name": "20OH-TrXA3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10433053", "map_id": "none", "name": "Homologues of CYP4F22", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10443219", "map_id": "none", "name": "CYP4F8 19-hydroxylates PGH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_30138", "map_id": "CHEBI:15554", "name": "PGH2", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_215545", "map_id": "CHEBI:63912", "name": "19OH-PGH2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10443216", "map_id": "none", "name": "Cytochrome P450 (CYP4F8 based)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10443328", "map_id": "none", "name": "CYP4F3 20-hydroxylates LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17960", "compartment_display": "smooth endoplasmic reticulum" }, { "id": "species_215557", "map_id": "CHEBI:15647", "name": "LTB4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_571314", "map_id": "CHEBI:15646", "name": "20OH-LTB4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10435630", "map_id": "none", "name": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435624", "map_id": "none", "name": "Mature intronless derived mRNA:TAP:Aly/Ref complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10435628", "map_id": "none", "name": "Mature Intronless Transcript Derived mRNA:eIF4E Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10433293", "map_id": "none", "name": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10433289", "map_id": "none", "name": "Mature intronless derived mRNA complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10433291", "map_id": "none", "name": "Nucleoplasmic mature intronless derived mRNA:TAP:Aly/Ref complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10435626", "map_id": "none", "name": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10435660", "map_id": "none", "name": "Release of the SLBP independent Histone mRNA from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435654", "map_id": "none", "name": "Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10435658", "map_id": "none", "name": "Mature SLBP independent Histone mRNA:eIF4E complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10434122", "map_id": "none", "name": "Docking of Mature Histone mRNA complex:TAP at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10434120", "map_id": "none", "name": "Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10435656", "map_id": "none", "name": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "reaction_10450430", "map_id": "none", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_449703", "map_id": "CHEBI:15784", "name": "AcGlcN6P", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_532204", "map_id": "CHEBI:7125", "name": "AcGlcN1P", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10450427", "map_id": "Q9VTZ4", "name": "nst", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0036298", "map_id": "FBgn0036298", "name": "nst", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10485958", "map_id": "none", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6803743", "map_id": "CHEBI:88130", "name": "GlcNGc-6-P", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10485955", "map_id": "Q9VR81", "name": "AMDHD2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031099", "map_id": "FBgn0031099", "name": "AMDHD2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450504", "map_id": "none", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450501", "map_id": "none", "name": "2xUAP1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9Y0Z0", "map_id": "Q9Y0Z0", "name": "mmy", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259749", "map_id": "FBgn0259749", "name": "mmy", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450806", "map_id": "none", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450803", "map_id": "none", "name": "GFPT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VAW3", "map_id": "Q9VAW3", "name": "Gfat2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039580", "map_id": "FBgn0039580", "name": "Gfat2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7PLC7", "map_id": "Q7PLC7", "name": "Gfat1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0287209", "map_id": "FBgn0287209", "name": "Gfat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10485950", "map_id": "none", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6803785", "map_id": "none", "name": "GlcNAc, GlcNGc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:27459", "map_id": "CHEBI:27459", "name": "CHEBI:27459", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6803738", "map_id": "none", "name": "GlcNAc-6-P, GlcNGc-6-P", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10485947", "map_id": "none", "name": "NAGK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VF86", "map_id": "Q9VF86", "name": "Dmel\\CG6218", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038321", "map_id": "FBgn0038321", "name": "Dmel\\CG6218", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450816", "map_id": "none", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450813", "map_id": "none", "name": "2xGNPNAT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VAI0", "map_id": "Q9VAI0", "name": "Gnpnat", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039690", "map_id": "FBgn0039690", "name": "Gnpnat", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10457936", "map_id": "none", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane" }, { "id": "species_10457933", "map_id": "none", "name": "V-ATPase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222693", "compartment_display": "phagocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10465115", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142780", "map_id": "CHEBI:34306", "name": "20-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10465112", "map_id": "none", "name": "CYP(3)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10465105", "map_id": "none", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142836", "map_id": "CHEBI:63998", "name": "19-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10465102", "map_id": "none", "name": "CYP(2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_350385", "map_id": "none", "name": "DSH binds to RAC1:GTP", "reversible": "false", "notes": "The DEP domain of Dishevelled (DSH) binds to activated Rac GTPase (RAC1:GTP).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_450786", "map_id": "none", "name": "PK:VANG:STAN dimer:FZ:DSH:DGO:RAC1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_450723", "map_id": "none", "name": "RAC1:GTP and MSN activate HEP", "reversible": "false", "notes": "Activated RAC1:GTP and the MAP kinase kinase kinase kinase (MKKKK) orthologue Misshapen (MSN) are involved in phosphorylating and activating the MKK orthologue Hemipterous (HEP). It is likely that a MKKK orthologue, currently unknown, is involved in directly phosphorylating HEP.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450710", "map_id": "Q9W002", "name": "MSN", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10450527", "map_id": "none", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449283", "map_id": "CHEBI:18396", "name": "MDCDD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449737", "map_id": "CHEBI:59085", "name": "(GlcNAc)2 (Man)2 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10450524", "map_id": "Q9VZU8", "name": "Alg2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0035401", "map_id": "FBgn0035401", "name": "Alg2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450543", "map_id": "none", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449315", "map_id": "CHEBI:53023", "name": "(GlcNAc)2 (Man)6 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449311", "map_id": "CHEBI:16214", "name": "DOLP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449312", "map_id": "CHEBI:59088", "name": "(GlcNAc)2 (Man)7 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10450540", "map_id": "Q9VBV8", "name": "Alg9", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0039293", "map_id": "FBgn0039293", "name": "Alg9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450441", "map_id": "Q9VMW8", "name": "MPDU1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0031662", "map_id": "FBgn0031662", "name": "MPDU1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450494", "map_id": "none", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449371", "map_id": "CHEBI:37637", "name": "(GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_532542", "map_id": "CHEBI:15812", "name": "DbGP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449649", "map_id": "CHEBI:59081", "name": "(Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10450491", "map_id": "Q9VKX7", "name": "gny", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0032234", "map_id": "FBgn0032234", "name": "gny", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450535", "map_id": "none", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_532214", "map_id": "CHEBI:15812", "name": "DbGP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10450532", "map_id": "Q9VLQ1", "name": "wol", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0261020", "map_id": "FBgn0261020", "name": "wol", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10486907", "map_id": "none", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10486904", "map_id": "Q9VB64", "name": "CG31063", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0261995", "map_id": "FBgn0261995", "name": "CG31063", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479928", "map_id": "none", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6787618", "map_id": "CHEBI:16955", "name": "GDP-DHDMan", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6787646", "map_id": "CHEBI:86476", "name": "GDP-KDGal", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479925", "map_id": "none", "name": "TSTA3 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W1X8", "map_id": "Q9W1X8", "name": "Gmer", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267823", "map_id": "FBgn0267823", "name": "Gmer", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479939", "map_id": "none", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10479936", "map_id": "none", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479933", "map_id": "Q9VMW9", "name": "Gmd", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031661", "map_id": "FBgn0031661", "name": "Gmd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10469805", "map_id": "none", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419981", "map_id": "CHEBI:67132", "name": "pPNOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_449221", "map_id": "CHEBI:16091", "name": "DCHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10469797", "map_id": "none", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_4419987", "map_id": "CHEBI:17407", "name": "E,E-FPP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_4419982", "map_id": "CHEBI:37531", "name": "pPPP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10469794", "map_id": "none", "name": "DHDDS:NUS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9W3M6", "map_id": "Q9W3M6", "name": "Dmel\\CG10778", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029980", "map_id": "FBgn0029980", "name": "Dmel\\CG10778", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPX8", "map_id": "Q9VPX8", "name": "Tango14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031312", "map_id": "FBgn0031312", "name": "Tango14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450468", "map_id": "none", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10450465", "map_id": "A1ZAI1", "name": "Dmel\\CG8311", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0034141", "map_id": "FBgn0034141", "name": "Dmel\\CG8311", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450460", "map_id": "none", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449222", "map_id": "CHEBI:18278", "name": "GlcNAcDOLDP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10450457", "map_id": "Q9VK30", "name": "Alg7", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0032477", "map_id": "FBgn0032477", "name": "Alg7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450476", "map_id": "none", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449365", "map_id": "CHEBI:59091", "name": "(GlcNAc)2 (Man)8 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10450473", "map_id": "Q9VH78", "name": "Alg12", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0037743", "map_id": "FBgn0037743", "name": "Alg12", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450443", "map_id": "none", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449298", "map_id": "CHEBI:53022", "name": "(GlcNAc)2 (Man)5 (PP-Dol)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10450435", "map_id": "Q27333", "name": "l(2)not", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0011297", "map_id": "FBgn0011297", "name": "l(2)not", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450553", "map_id": "none", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_449293", "map_id": "CHEBI:18341", "name": "N,N'-DCDOLDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453087", "compartment_display": "integral component of cytoplasmic side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10450550", "map_id": "Q9VEE9", "name": "Alg1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0038552", "map_id": "FBgn0038552", "name": "Alg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450519", "map_id": "none", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10450516", "map_id": "none", "name": "ALG13:ALG14", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VAP1", "map_id": "Q9VAP1", "name": "Alg13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039639", "map_id": "FBgn0039639", "name": "Alg13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXU7", "map_id": "Q9VXU7", "name": "Alg14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030645", "map_id": "FBgn0030645", "name": "Alg14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450452", "map_id": "none", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_449638", "map_id": "CHEBI:53020", "name": "(Glc)2 (GlcNAc)2 (Man)9 (PP-Dol)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_453088", "compartment_display": "integral component of lumenal side of endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10450449", "map_id": "Q9W3V8", "name": "xit", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0029906", "map_id": "FBgn0029906", "name": "xit", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450545", "map_id": "none", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "reaction_10435743", "map_id": "none", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10435738", "map_id": "none", "name": "polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10432271", "map_id": "none", "name": "NXF1,2:NXT1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VV73", "map_id": "Q9VV73", "name": "nxf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036640", "map_id": "FBgn0036640", "name": "nxf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQK4", "map_id": "Q8IQK4", "name": "Nxf3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263232", "map_id": "FBgn0263232", "name": "Nxf3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3H8", "map_id": "Q9V3H8", "name": "Nxt1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028411", "map_id": "FBgn0028411", "name": "Nxt1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10432277", "map_id": "none", "name": "NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10435740", "map_id": "none", "name": "DDX39B:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432342", "map_id": "none", "name": "mRNP complex dissociates from cytosolic face of NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10432329", "map_id": "none", "name": "NPC:NXF1:NXT1:EJC:CBC:mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10432340", "map_id": "none", "name": "mRNA:CBC:EJC:POLDIP3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10432301", "map_id": "none", "name": "NXF1,2:NXT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10432336", "map_id": "none", "name": "Transport of the export-competent mRNP complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13231", "compartment_display": "nuclear envelope" }, { "id": "species_10432279", "map_id": "none", "name": "NPC:NXF1,2:NXT1:EJC:CBC:mRNA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10432334", "map_id": "Q9V4W1", "name": "Gle1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0033316", "map_id": "FBgn0033316", "name": "Gle1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439582", "map_id": "none", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_189411", "map_id": "CHEBI:15439", "name": "COPRO3", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189480", "map_id": "CHEBI:16526", "name": "CO2", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_189478", "map_id": "CHEBI:15435", "name": "PPGEN9", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10439579", "map_id": "none", "name": "2xCPO", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q9V3D2", "map_id": "Q9V3D2", "name": "Coprox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0021944", "map_id": "FBgn0021944", "name": "Coprox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10467261", "map_id": "none", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_2995328", "map_id": "CHEBI:24480", "name": "heme O", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_2995348", "map_id": "CHEBI:24479", "name": "heme A", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10467258", "map_id": "Q9W1F5", "name": "Dmel\\CG3803", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0034938", "map_id": "FBgn0034938", "name": "Dmel\\CG3803", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439612", "map_id": "none", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189489", "map_id": "CHEBI:356416", "name": "dALA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_189464", "map_id": "CHEBI:58126", "name": "PBG", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439609", "map_id": "none", "name": "8x(ALAD:Zn2+)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10439640", "map_id": "none", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189487", "map_id": "CHEBI:15430", "name": "PRIN9", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10439637", "map_id": "none", "name": "2x(FECH:2Fe-2S cluster)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9V9S8", "map_id": "Q9V9S8", "name": "FeCh", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266268", "map_id": "FBgn0266268", "name": "FeCh", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_391232", "map_id": "CHEBI:27889", "name": "Pb2+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "reaction_10455127", "map_id": "none", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_917877", "map_id": "CHEBI:17627", "name": "heme", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10467253", "map_id": "none", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10467250", "map_id": "Q9VKZ1", "name": "Dmel\\CG5037", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "FBgn0032222", "map_id": "FBgn0032222", "name": "Dmel\\CG5037", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439572", "map_id": "none", "name": "4 PBGs bind to form HMB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189449", "map_id": "CHEBI:57845", "name": "HMBL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439569", "map_id": "none", "name": "HMBS:DIPY", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W0G4", "map_id": "Q9W0G4", "name": "l(3)02640", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010786", "map_id": "FBgn0010786", "name": "l(3)02640", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:36319", "map_id": "CHEBI:36319", "name": "CHEBI:36319", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439602", "map_id": "none", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_189407", "map_id": "CHEBI:15437", "name": "URO3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_189455", "map_id": "CHEBI:15439", "name": "COPRO3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10439599", "map_id": "none", "name": "2xUROD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V595", "map_id": "Q9V595", "name": "Urod", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033428", "map_id": "FBgn0033428", "name": "Urod", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439630", "map_id": "none", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_189466", "map_id": "CHEBI:356416", "name": "dALA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10439627", "map_id": "none", "name": "ALAS1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "O18680", "map_id": "O18680", "name": "Alas", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020764", "map_id": "FBgn0020764", "name": "Alas", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439592", "map_id": "none", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space" }, { "id": "species_189463", "map_id": "CHEBI:15430", "name": "PRIN9", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_10439589", "map_id": "none", "name": "2xPPOX:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "true" }, { "id": "Q9VC52", "map_id": "Q9VC52", "name": "Ppox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0020018", "map_id": "FBgn0020018", "name": "Ppox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10439654", "map_id": "none", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_190157", "map_id": "CHEBI:28766", "name": "URO1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_190128", "map_id": "CHEBI:28607", "name": "COPRO1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10439652", "map_id": "none", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_190173", "map_id": "CHEBI:27889", "name": "Pb2+", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10439650", "map_id": "none", "name": "8xALAD:Pb2+:Zn2+", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10439648", "map_id": "none", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439645", "map_id": "Q9W3B3", "name": "Uros1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030066", "map_id": "FBgn0030066", "name": "Uros1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10453037", "map_id": "none", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10453034", "map_id": "none", "name": "GLUT1,2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447180", "map_id": "none", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447177", "map_id": "none", "name": "PLC beta1,2,3:G-alpha(q):GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10443692", "map_id": "none", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10443689", "map_id": "none", "name": "Voltage-gated Calcium Channels (pancreatic beta cell)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P91645", "map_id": "P91645", "name": "cac", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0263111", "map_id": "FBgn0263111", "name": "cac", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10449645", "map_id": "none", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_400452", "map_id": "CHEBI:15756", "name": "PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10449642", "map_id": "E1JI63", "name": "Snmp2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10447214", "map_id": "none", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447212", "map_id": "none", "name": "G-alpha(i,o):GDP:G beta:G gamma", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10447204", "map_id": "none", "name": "G-alpha(i,o):GTP:G-beta:G-gamma", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447208", "map_id": "none", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10447206", "map_id": "none", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447202", "map_id": "none", "name": "G-beta:G-gamma (candidates)", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10447196", "map_id": "none", "name": "G-alpha(i,o):GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447221", "map_id": "none", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10447217", "map_id": "none", "name": "Adenylate Cyclase V or VI", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10447219", "map_id": "none", "name": "Adenylate cyclase type V or VI: G-protein beta gamma Complex", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10446063", "map_id": "none", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10446061", "map_id": "none", "name": "RAP1A:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446001", "map_id": "none", "name": "RAPGEF4:cAMP Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446059", "map_id": "none", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10446057", "map_id": "none", "name": "Potassium voltage-gated channels (beta cell, open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446027", "map_id": "none", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10446017", "map_id": "none", "name": "Ca-channel (closed)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "species_10446025", "map_id": "none", "name": "Ca-channel (open)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10446003", "map_id": "none", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10445999", "map_id": "A1Z6P8", "name": "Epac", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10446034", "map_id": "none", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10430876", "map_id": "none", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76632", "map_id": "CHEBI:16742", "name": "ORO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_111629", "map_id": "CHEBI:15842", "name": "OMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430870", "map_id": "none", "name": "UMPS dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q01637", "map_id": "Q01637", "name": "r-l", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003257", "map_id": "FBgn0003257", "name": "r-l", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430873", "map_id": "none", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10430902", "map_id": "none", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111647", "map_id": "CHEBI:17672", "name": "CAP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430893", "map_id": "none", "name": "CAD hexamer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "P05990", "map_id": "P05990", "name": "r", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003189", "map_id": "FBgn0003189", "name": "r", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430886", "map_id": "none", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_76630", "map_id": "CHEBI:17025", "name": "(S)-DHO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430883", "map_id": "none", "name": "DHODH:FMN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "P32748", "map_id": "P32748", "name": "Dhod", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000447", "map_id": "FBgn0000447", "name": "Dhod", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430899", "map_id": "none", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_111628", "map_id": "CHEBI:15859", "name": "N-carb-L-Asp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10430896", "map_id": "none", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10490053", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8866574", "map_id": "CHEBI:61560", "name": "dNTP(4-)", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866608", "map_id": "CHEBI:18274", "name": "2'-deoxynucleoside", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_8866567", "map_id": "CHEBI:18036", "name": "PPPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10490050", "map_id": "none", "name": "SAMHD1:Zn2+ tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VVY4", "map_id": "Q9VVY4", "name": "fal", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028380", "map_id": "FBgn0028380", "name": "fal", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430942", "map_id": "none", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73588", "map_id": "CHEBI:18261", "name": "UPROP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430939", "map_id": "none", "name": "UPB1:Zn2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VI04", "map_id": "Q9VI04", "name": "pyd3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037513", "map_id": "FBgn0037513", "name": "pyd3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430974", "map_id": "none", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_83960", "map_id": "CHEBI:17821", "name": "Thy", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73541", "map_id": "CHEBI:27468", "name": "5,6-Dihydrothymine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10430919", "map_id": "none", "name": "DPYD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W374", "map_id": "Q9W374", "name": "su(r)", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086450", "map_id": "FBgn0086450", "name": "su(r)", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10431581", "map_id": "none", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10433355", "map_id": "none", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_500347", "map_id": "none", "name": "(d)CMP, TMP, (d)UMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_500346", "map_id": "none", "name": "(d)C, T, (d)U", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10433352", "map_id": "none", "name": "NT5C3 holoenzyme", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W197", "map_id": "Q9W197", "name": "cN-IIIB", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10430922", "map_id": "none", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73584", "map_id": "CHEBI:15901", "name": "5,6-Dihydrouracil", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10433333", "map_id": "none", "name": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_500316", "map_id": "none", "name": "CMP, TMP, UMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_500318", "map_id": "none", "name": "Cyt-Rib, Thy-dRib, Ura-Rib", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10430932", "map_id": "none", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10430929", "map_id": "none", "name": "DPYS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10430978", "map_id": "none", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_73617", "map_id": "CHEBI:1670", "name": "UIBA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_73619", "map_id": "CHEBI:16320", "name": "3AIB", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10430976", "map_id": "none", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10488423", "map_id": "none", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8936165", "map_id": "none", "name": "ADP,GDP,CDP,UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_8851369", "map_id": "none", "name": "AMP,GMP,CMP,UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10488420", "map_id": "none", "name": "NPTDase5:Ca2+,Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "M9PBV2", "map_id": "M9PBV2", "name": "NTPase", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024947", "map_id": "FBgn0024947", "name": "NTPase", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488430", "map_id": "none", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8851462", "map_id": "none", "name": "CDP,GDP,IDP,UDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:17808", "map_id": "CHEBI:17808", "name": "CHEBI:17808", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8851461", "map_id": "none", "name": "CMP,GMP,IMP,UMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10488427", "map_id": "none", "name": "NTPDase6:Ca2+,Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10498277", "map_id": "none", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10498275", "map_id": "none", "name": "Homologues of SERPING1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10452491", "map_id": "none", "name": "Homologues of SERPING1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10472854", "map_id": "none", "name": "factor IXa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10435383", "map_id": "none", "name": "factor IXa", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10472852", "map_id": "none", "name": "factor IXa", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10498442", "map_id": "none", "name": "FIX is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10498440", "map_id": "none", "name": "Homologues of F9(29-461)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10435369", "map_id": "none", "name": "Homologues of 12xCbxE-3D-F9(47-461)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10478063", "map_id": "none", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_2022135", "map_id": "CHEBI:16134", "name": "NH3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_83921", "map_id": "CHEBI:17596", "name": "Ino", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10478060", "map_id": "none", "name": "CECR1:Zn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10497731", "map_id": "none", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10497729", "map_id": "Q9Y125", "name": "Sap-r", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10476466", "map_id": "Q9Y125", "name": "Sap-r", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "reaction_10476537", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_5685882", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10476468", "map_id": "Q9Y125", "name": "Sap-r", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10476470", "map_id": "Q9Y125", "name": "Sap-r", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10476472", "map_id": "Q9Y125", "name": "Sap-r", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "false" }, { "id": "species_10476534", "map_id": "none", "name": "NAPSA, CTSH, PGA3-5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "reaction_10480360", "map_id": "none", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen" }, { "id": "species_10476539", "map_id": "none", "name": "SFTPB dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_3828046", "compartment_display": "multivesicular body lumen", "complex": "true" }, { "id": "reaction_10476405", "map_id": "none", "name": "LMCD1 binds GATA6, sequestering it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10476401", "map_id": "A1ZAT5", "name": "Tes", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0034223", "map_id": "FBgn0034223", "name": "Tes", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10457526", "map_id": "none", "name": "Homologues of GATA6", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10476403", "map_id": "none", "name": "LMCD1:GATA6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "A1ZAT5", "map_id": "A1ZAT5", "name": "Tes", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10498522", "map_id": "none", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10498518", "map_id": "none", "name": "HDAC1:2-containing complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VXB3", "map_id": "Q9VXB3", "name": "Sap30", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030788", "map_id": "FBgn0030788", "name": "Sap30", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VWP5", "map_id": "Q9VWP5", "name": "htk", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0085451", "map_id": "FBgn0085451", "name": "htk", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEX9", "map_id": "Q9VEX9", "name": "Bin1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024491", "map_id": "FBgn0024491", "name": "Bin1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYI2", "map_id": "Q9VYI2", "name": "Brms1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030434", "map_id": "FBgn0030434", "name": "Brms1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK36", "map_id": "Q9VK36", "name": "kmg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032473", "map_id": "FBgn0032473", "name": "kmg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T092", "map_id": "Q8T092", "name": "Dmel\\CG4282", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034114", "map_id": "FBgn0034114", "name": "Dmel\\CG4282", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VRV0", "map_id": "Q9VRV0", "name": "Prdm13", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035687", "map_id": "FBgn0035687", "name": "Prdm13", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VH18", "map_id": "Q9VH18", "name": "Dmel\\CG6254", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037794", "map_id": "FBgn0037794", "name": "Dmel\\CG6254", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W137", "map_id": "Q9W137", "name": "Cg4707", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035036", "map_id": "FBgn0035036", "name": "Cg4707", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIS9", "map_id": "Q9VIS9", "name": "Dmel\\CG10366", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032814", "map_id": "FBgn0032814", "name": "Dmel\\CG10366", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZBC5", "map_id": "A1ZBC5", "name": "Dmel\\CG15073", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034379", "map_id": "FBgn0034379", "name": "Dmel\\CG15073", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_9679795", "map_id": "none", "name": "HDAC2 inhibitors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10498520", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023929", "map_id": "CHEBI:17401", "name": "IP6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10461577", "map_id": "Q9W2Q7", "name": "Ipk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0050295", "map_id": "FBgn0050295", "name": "Ipk1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461738", "map_id": "none", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_2023932", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_2023931", "map_id": "CHEBI:62923", "name": "1,5-(PP)2-IP4", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10461655", "map_id": "none", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629770", "map_id": "CHEBI:17401", "name": "IP6", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10461641", "map_id": "none", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10461608", "map_id": "none", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10461605", "map_id": "Q9W2Q7", "name": "Ipk1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10461735", "map_id": "none", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10461638", "map_id": "none", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629740", "map_id": "CHEBI:62919", "name": "1-PP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10461701", "map_id": "none", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10461635", "map_id": "none", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629738", "map_id": "CHEBI:62931", "name": "1,5-(PP)2-IP3", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10461536", "map_id": "none", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1629759", "map_id": "CHEBI:62985", "name": "5-PPP-IP5", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10442750", "map_id": "none", "name": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_209800", "map_id": "CHEBI:17823", "name": "1,25(OH)2D", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_350159", "map_id": "CHEBI:47828", "name": "CTA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10495353", "map_id": "none", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10495351", "map_id": "none", "name": "CUBN:25(OH)D", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_350136", "map_id": "CHEBI:17933", "name": "25(OH)D", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "species_10495349", "map_id": "A8JQY3", "name": "CG4940", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "false" }, { "id": "reaction_10495357", "map_id": "none", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_8963912", "map_id": "CHEBI:17823", "name": "1,25(OH)2D", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10495355", "map_id": "none", "name": "1,25(OH)2D:VDR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10460847", "map_id": "none", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10460835", "map_id": "none", "name": "SREBP1A,1C,2:Importin beta-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VW37", "map_id": "Q9VW37", "name": "SREBP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261283", "map_id": "FBgn0261283", "name": "SREBP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460845", "map_id": "none", "name": "SREBP1A,1C,2:Importin beta-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10464750", "map_id": "none", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10460827", "map_id": "Q9VW37", "name": "SREBP", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10460833", "map_id": "none", "name": "SREBP1A,1C,2 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10464748", "map_id": "none", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10442310", "map_id": "none", "name": "RAN:GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10464746", "map_id": "none", "name": "Importin-beta:Ran GTP complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10460843", "map_id": "none", "name": "SREBP1A,1C,2 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10460870", "map_id": "none", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10460862", "map_id": "Q9VW37", "name": "SREBP", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "reaction_10460868", "map_id": "none", "name": "S1P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10460860", "map_id": "none", "name": "SREBP1A,1C,2:SCAP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "A1Z6J2", "map_id": "A1Z6J2", "name": "SCAP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033052", "map_id": "FBgn0033052", "name": "SCAP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10460858", "map_id": "none", "name": "SCAP tetramer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "true" }, { "id": "reaction_10464752", "map_id": "none", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10446655", "map_id": "none", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_8848577", "map_id": "CHEBI:16125", "name": "HXOL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10446652", "map_id": "Q9VCF6", "name": "Dmel\\CG12268", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "FBgn0039131", "map_id": "FBgn0039131", "name": "Dmel\\CG12268", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487936", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8848499", "map_id": "CHEBI:75584", "name": "PALM-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10446670", "map_id": "none", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10446667", "map_id": "none", "name": "Homologues of FAR2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "Q9VES6", "map_id": "Q9VES6", "name": "Dmel\\CG17560", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038450", "map_id": "FBgn0038450", "name": "Dmel\\CG17560", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VES5", "map_id": "Q9VES5", "name": "CT34717", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038451", "map_id": "FBgn0038451", "name": "CT34717", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487938", "map_id": "none", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_30209", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2534407", "map_id": "CHEBI:17616", "name": "atR-PALM", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "reaction_10479146", "map_id": "none", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_192172", "map_id": "CHEBI:17984", "name": "Acyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696426", "map_id": "CHEBI:75627", "name": "ARACOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5696412", "map_id": "CHEBI:10036", "name": "arachidyl ester", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10479143", "map_id": "none", "name": "Homologues of AWAT1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10489409", "map_id": "none", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10489403", "map_id": "Q9VRJ2", "name": "Fitm2", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0035586", "map_id": "FBgn0035586", "name": "Fitm2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489407", "map_id": "none", "name": "(FITM1,FITM2):TAGs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9VRJ2", "map_id": "Q9VRJ2", "name": "Fitm2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10489306", "map_id": "none", "name": "CIDEA:CIDEC binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13977", "compartment_display": "lipid droplet" }, { "id": "species_8866926", "map_id": "none", "name": "lipid droplet", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "species_163579", "map_id": "CHEBI:17002", "name": "CHEST", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "CHEBI:16247", "map_id": "CHEBI:16247", "name": "CHEBI:16247", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489302", "map_id": "none", "name": "CIDEA:CIDEC", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A8DY77", "map_id": "A8DY77", "name": "Drep2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028408", "map_id": "FBgn0028408", "name": "Drep2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E9B7", "map_id": "Q0E9B7", "name": "Drep3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028407", "map_id": "FBgn0028407", "name": "Drep3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10489304", "map_id": "none", "name": "CIDEA:CIDEC:lipid droplet", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "reaction_10489517", "map_id": "none", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10489515", "map_id": "none", "name": "HSD17B13:lipid droplet", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "reaction_10465087", "map_id": "none", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2142740", "map_id": "CHEBI:63979", "name": "20cho-LTB4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465100", "map_id": "none", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_2161582", "map_id": "CHEBI:27562", "name": "20cooh-LTB4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10443833", "map_id": "none", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_266066", "map_id": "CHEBI:16978", "name": "LTC4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10443764", "map_id": "none", "name": "LTD4 is converted to LTE4 by DPEP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10443843", "map_id": "none", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_265281", "map_id": "CHEBI:15651", "name": "LTA4", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10443825", "map_id": "none", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10443822", "map_id": "none", "name": "GGT1, 5 dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10465110", "map_id": "none", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_29768", "map_id": "CHEBI:15843", "name": "AA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2161753", "map_id": "none", "name": "8,9/11,12/14,15-EET", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10432779", "map_id": "none", "name": "Homologues of CYP2J2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10465108", "map_id": "none", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10465126", "map_id": "none", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142811", "map_id": "CHEBI:15626", "name": "12S-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142678", "map_id": "CHEBI:34146", "name": "12S-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465121", "map_id": "Q8IRD3", "name": "PHGPx", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10465124", "map_id": "none", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2142790", "map_id": "CHEBI:34145", "name": "12R-HpETE", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_2142716", "map_id": "CHEBI:34144", "name": "12R-HETE", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10478161", "map_id": "none", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_13977", "compartment_display": "lipid droplet" }, { "id": "species_5693752", "map_id": "CHEBI:2700", "name": "AEA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_5693747", "map_id": "CHEBI:15377", "name": "H2O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_5693736", "map_id": "CHEBI:16000", "name": "ETA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_5693733", "map_id": "CHEBI:15843", "name": "AA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "species_10478158", "map_id": "Q7K2E1", "name": "Dmel\\CG8839", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "false" }, { "id": "FBgn0033717", "map_id": "FBgn0033717", "name": "Dmel\\CG8839", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464589", "map_id": "none", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046052", "map_id": "CHEBI:63545", "name": "SDA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046051", "map_id": "CHEBI:63542", "name": "ETA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "reaction_10464587", "map_id": "none", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_2046054", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_2046047", "map_id": "CHEBI:63540", "name": "THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10464779", "map_id": "none", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066767", "map_id": "CHEBI:65139", "name": "delta2-THA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446616", "map_id": "none", "name": "ACOX1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10464777", "map_id": "none", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_2066766", "map_id": "CHEBI:65130", "name": "1-3-hydroxy-THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_2066762", "map_id": "CHEBI:65131", "name": "1-3-oxo-THA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10464775", "map_id": "none", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10491976", "map_id": "none", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10491965", "map_id": "Q94519", "name": "phospho-ND-ACP", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_977314", "map_id": "CHEBI:15531", "name": "Malonyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10491968", "map_id": "Q94519", "name": "phospho-ND-ACP", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10491973", "map_id": "Q8T3L6", "name": "beg", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0036691", "map_id": "FBgn0036691", "name": "beg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487865", "map_id": "none", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_8848288", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_164991", "map_id": "CHEBI:33184", "name": "LCFA-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_5690542", "map_id": "CHEBI:61907", "name": "MCFA-CoA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10487859", "map_id": "Q9VLS4", "name": "Acbp1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "FBgn0031992", "map_id": "FBgn0031992", "name": "Acbp1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487863", "map_id": "none", "name": "DBI,ACBD7:MCFA-CoA,LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q9VLS4", "map_id": "Q9VLS4", "name": "Acbp1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477557", "map_id": "none", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5690540", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5690519", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "species_5690531", "map_id": "CHEBI:59554", "name": "MCFA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10477554", "map_id": "Q95TK5", "name": "Dmel\\CG1635", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0039854", "map_id": "FBgn0039854", "name": "Dmel\\CG1635", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477541", "map_id": "none", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5690044", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5690064", "map_id": "none", "name": "MCFA, LCFA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10477538", "map_id": "none", "name": "ACOT13 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VZZ6", "map_id": "Q9VZZ6", "name": "BcDNA:RE30174", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035355", "map_id": "FBgn0035355", "name": "BcDNA:RE30174", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZZ5", "map_id": "Q9VZZ5", "name": "Dmel\\CG16986", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035356", "map_id": "FBgn0035356", "name": "Dmel\\CG16986", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491084", "map_id": "none", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_8874749", "map_id": "CHEBI:15489", "name": "3OA-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10491081", "map_id": "none", "name": "ACAA2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "Q9VL70", "map_id": "Q9VL70", "name": "yip2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040064", "map_id": "FBgn0040064", "name": "yip2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479074", "map_id": "none", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_10479071", "map_id": "Q9VMR6", "name": "Dmel\\CG12512", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "FBgn0031703", "map_id": "FBgn0031703", "name": "Dmel\\CG12512", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10487885", "map_id": "none", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10487881", "map_id": "Q9VRG6", "name": "anox", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0064116", "map_id": "FBgn0064116", "name": "anox", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10487883", "map_id": "none", "name": "ACBD6:LCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VRG6", "map_id": "Q9VRG6", "name": "anox", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479965", "map_id": "none", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6787810", "map_id": "CHEBI:65101", "name": "2OH-PALM", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6787814", "map_id": "CHEBI:86988", "name": "2oxo-PALM", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10479962", "map_id": "none", "name": "HAO2 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10486915", "map_id": "none", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6810523", "map_id": "CHEBI:37554", "name": "FA-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6809360", "map_id": "CHEBI:37240", "name": "3',5'-ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_6810530", "map_id": "CHEBI:47983", "name": "acyl-PPANT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10486912", "map_id": "Q9VIV6", "name": "Dmel\\CG10194", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10487876", "map_id": "none", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_5690520", "map_id": "none", "name": "MCFA-CoA, LCFA-CoA", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "species_10487870", "map_id": "Q9VQI6", "name": "DmCG8814", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "species_10487874", "map_id": "none", "name": "ACBD4,5:LCFA-CoA, MCFA-CoA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10446606", "map_id": "none", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389982", "map_id": "CHEBI:63914", "name": "3-hydroxypristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389996", "map_id": "CHEBI:15371", "name": "3-ketopristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446589", "map_id": "none", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389893", "map_id": "CHEBI:64039", "name": "(2S) Pristanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389894", "map_id": "CHEBI:63803", "name": "trans-2,3-dehydropristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446637", "map_id": "none", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_353123", "map_id": "CHEBI:15351", "name": "Ac-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390294", "map_id": "CHEBI:17126", "name": "CAR", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390287", "map_id": "CHEBI:15960", "name": "ACAR", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_193514", "map_id": "CHEBI:15346", "name": "CoA-SH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446632", "map_id": "Q9VEM4", "name": "Dmel\\CG5265", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446604", "map_id": "none", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "reaction_10446635", "map_id": "none", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_192314", "map_id": "CHEBI:15539", "name": "propionyl CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390274", "map_id": "CHEBI:28867", "name": "Propionylcarnitine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446601", "map_id": "none", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389569", "map_id": "CHEBI:51341", "name": "(2R) Pristanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446599", "map_id": "none", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_10446596", "map_id": "none", "name": "ACOX3:FAD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10446627", "map_id": "none", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390271", "map_id": "CHEBI:63856", "name": "4,8-dimethylnonanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390290", "map_id": "CHEBI:63874", "name": "4,8-dimethylnonanoylcarnitine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446624", "map_id": "Q9VB02", "name": "CROT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446619", "map_id": "none", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390260", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_390249", "map_id": "CHEBI:52975", "name": "trans-2,3-dehydrohexacosanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446647", "map_id": "none", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_390394", "map_id": "CHEBI:52966", "name": "C26:0 CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10446279", "map_id": "none", "name": "ABCD1 homodimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10446610", "map_id": "none", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390248", "map_id": "CHEBI:64972", "name": "3-hydroxyhexacosanoyl-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446608", "map_id": "none", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_390241", "map_id": "CHEBI:52977", "name": "3-ketohexacosanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446474", "map_id": "none", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389594", "map_id": "CHEBI:15475", "name": "3S2HPhy-CoA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389578", "map_id": "CHEBI:15522", "name": "FOR-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389636", "map_id": "CHEBI:49189", "name": "Pristanal", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446471", "map_id": "none", "name": "HACL1 tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "true" }, { "id": "reaction_10446488", "map_id": "none", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_6811612", "map_id": "CHEBI:77268", "name": "pristanate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389573", "map_id": "CHEBI:30616", "name": "ATP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389593", "map_id": "CHEBI:29888", "name": "PPi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389620", "map_id": "CHEBI:16027", "name": "AMP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_10446482", "map_id": "none", "name": "Homologues of SLC27A2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "true" }, { "id": "reaction_10446485", "map_id": "none", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix" }, { "id": "species_389596", "map_id": "CHEBI:16285", "name": "Phytanate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "species_389615", "map_id": "CHEBI:15538", "name": "Phytanoyl-CoA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17951", "compartment_display": "peroxisomal matrix", "complex": "false" }, { "id": "reaction_10446496", "map_id": "none", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane" }, { "id": "species_10446493", "map_id": "Q9VZD9", "name": "PMP34", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17947", "compartment_display": "peroxisomal membrane", "complex": "false" }, { "id": "reaction_10484754", "map_id": "none", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6806829", "map_id": "CHEBI:17826", "name": "MMAIII", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6800127", "map_id": "CHEBI:48765", "name": "DMAA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10479105", "map_id": "none", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5696214", "map_id": "CHEBI:16005", "name": "methylarsonate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5696224", "map_id": "CHEBI:14597", "name": "methylarsonite", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438462", "map_id": "none", "name": "GSTO1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438713", "map_id": "none", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438710", "map_id": "none", "name": "SULTs active on DHEA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W1L8", "map_id": "Q9W1L8", "name": "St1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034887", "map_id": "FBgn0034887", "name": "St1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHH0", "map_id": "Q9VHH0", "name": "St2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037665", "map_id": "FBgn0037665", "name": "St2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z9J8", "map_id": "A1Z9J8", "name": "St4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033887", "map_id": "FBgn0033887", "name": "St4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438678", "map_id": "none", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176492", "map_id": "CHEBI:4866", "name": "E2-SO4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438632", "map_id": "none", "name": "SULT1E1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438708", "map_id": "none", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176618", "map_id": "CHEBI:41321", "name": "cholesterol sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438667", "map_id": "none", "name": "SULT2B1-2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438675", "map_id": "none", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176665", "map_id": "CHEBI:35420", "name": "PREGS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438672", "map_id": "none", "name": "SULTs active on pregnenolone", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438738", "map_id": "none", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176566", "map_id": "CHEBI:17931", "name": "N-hydroxy-2-acetylaminofluorene", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176500", "map_id": "CHEBI:35424", "name": "AAF-N-S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438735", "map_id": "none", "name": "SULTs active on NH2AAF", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438706", "map_id": "none", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438703", "map_id": "Q9VAG9", "name": "Dmel\\CG7789", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0039698", "map_id": "FBgn0039698", "name": "Dmel\\CG7789", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10435664", "map_id": "none", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158847", "map_id": "CHEBI:16580", "name": "NHABP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158859", "map_id": "CHEBI:32701", "name": "NHABP-SO4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10435649", "map_id": "none", "name": "SULT1A1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10435662", "map_id": "none", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158858", "map_id": "CHEBI:15882", "name": "PhOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158850", "map_id": "CHEBI:27905", "name": "Phenyl sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10438670", "map_id": "none", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176617", "map_id": "CHEBI:17703", "name": "27HCHOL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_176502", "map_id": "CHEBI:35419", "name": "27HCHOL3S", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10438733", "map_id": "none", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10438730", "map_id": "none", "name": "SULT1E1,2A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10494994", "map_id": "none", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_8851226", "map_id": "CHEBI:43474", "name": "Pi", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_8953493", "map_id": "CHEBI:16027", "name": "adenosine 5'-monophosphate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10494991", "map_id": "none", "name": "IMPAD1:Mg2+", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "Q9VYF2", "map_id": "Q9VYF2", "name": "IMPAD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030465", "map_id": "FBgn0030465", "name": "IMPAD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8953505", "map_id": "CHEBI:49713", "name": "Li+", "type": "inhibitor", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10438698", "map_id": "none", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176565", "map_id": "CHEBI:17179", "name": "taurolithocholate", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438642", "map_id": "none", "name": "SULT2A1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438728", "map_id": "none", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5695950", "map_id": "CHEBI:16836", "name": "PNP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176600", "map_id": "CHEBI:35422", "name": "p-nitrophenol sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438725", "map_id": "none", "name": "SULT1A1,A2,C2,4A1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438696", "map_id": "none", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176555", "map_id": "CHEBI:35421", "name": "lithocholate sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10438693", "map_id": "none", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176564", "map_id": "CHEBI:35432", "name": "3,5,3'-triiodothyronine 4-sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438690", "map_id": "none", "name": "SULT dimers (T3)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10435652", "map_id": "none", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_158469", "map_id": "CHEBI:46195", "name": "PARA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_158472", "map_id": "CHEBI:32635", "name": "PARA-SO4", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10435745", "map_id": "none", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_159352", "map_id": "CHEBI:37946", "name": "DAOS", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10438657", "map_id": "none", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176486", "map_id": "CHEBI:35430", "name": "3,3'-diiodothyronine", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_176519", "map_id": "CHEBI:35431", "name": "3,3'-diiodothyronine 4-sulfate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438654", "map_id": "none", "name": "SULT dimers (T2)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10438525", "map_id": "none", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_176070", "map_id": "none", "name": "Electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:29132", "map_id": "CHEBI:29132", "name": "CHEBI:29132", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34718", "map_id": "CHEBI:34718", "name": "CHEBI:34718", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:30614", "map_id": "CHEBI:30614", "name": "CHEBI:30614", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176049", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:8927", "map_id": "CHEBI:8927", "name": "CHEBI:8927", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:32639", "map_id": "CHEBI:32639", "name": "CHEBI:32639", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:34479", "map_id": "CHEBI:34479", "name": "CHEBI:34479", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10438522", "map_id": "none", "name": "GST dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1Z7X7", "map_id": "A1Z7X7", "name": "GstT2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050005", "map_id": "FBgn0050005", "name": "GstT2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8MRM0", "map_id": "Q8MRM0", "name": "GstT4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030484", "map_id": "FBgn0030484", "name": "GstT4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K0B6", "map_id": "Q7K0B6", "name": "GstT1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0050000", "map_id": "FBgn0050000", "name": "GstT1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "E1JJS1", "map_id": "E1JJS1", "name": "GstT3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031117", "map_id": "FBgn0031117", "name": "GstT3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10438399", "map_id": "none", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_174393", "map_id": "CHEBI:17515", "name": "gGluCys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10438396", "map_id": "none", "name": "GCL", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VCW6", "map_id": "Q9VCW6", "name": "Gclm", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0046114", "map_id": "FBgn0046114", "name": "Gclm", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3K5", "map_id": "Q9W3K5", "name": "Gclc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040319", "map_id": "FBgn0040319", "name": "Gclc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458317", "map_id": "none", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1247942", "map_id": "CHEBI:18183", "name": "OPRO", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458314", "map_id": "none", "name": "OPLAH", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W247", "map_id": "Q9W247", "name": "Dmel\\CG4752", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034733", "map_id": "FBgn0034733", "name": "Dmel\\CG4752", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493315", "map_id": "none", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_1247892", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_1247934", "map_id": "CHEBI:4047", "name": "CysGly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10458297", "map_id": "none", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1247904", "map_id": "CHEBI:4047", "name": "CysGly", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458294", "map_id": "none", "name": "CNDP2:2Mn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8MT58", "map_id": "Q8MT58", "name": "Cndp2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0259979", "map_id": "FBgn0259979", "name": "Cndp2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479737", "map_id": "none", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479732", "map_id": "Q9VYK7", "name": "Dmel\\CG2540", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030411", "map_id": "FBgn0030411", "name": "Dmel\\CG2540", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458307", "map_id": "none", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458304", "map_id": "none", "name": "GGCT dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IQT0", "map_id": "Q8IQT0", "name": "Dmel\\CG32196", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052196", "map_id": "FBgn0052196", "name": "Dmel\\CG32196", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478153", "map_id": "none", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5693723", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_158543", "map_id": "CHEBI:16856", "name": "GSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_194712", "map_id": "CHEBI:30751", "name": "formate", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10478150", "map_id": "none", "name": "ESD dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q7KSB5", "map_id": "Q7KSB5", "name": "Dmel\\CG4390", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038771", "map_id": "FBgn0038771", "name": "Dmel\\CG4390", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477976", "map_id": "none", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692212", "map_id": "CHEBI:81626", "name": "BaPtDHD", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692216", "map_id": "CHEBI:87752", "name": "BaP-7,8-dione", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10438535", "map_id": "none", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_176065", "map_id": "none", "name": "electrophilic substrate", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:27561", "map_id": "CHEBI:27561", "name": "CHEBI:27561", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_176048", "map_id": "none", "name": "electrophilic substrate:SG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "CHEBI:2505", "map_id": "CHEBI:2505", "name": "CHEBI:2505", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:35896", "map_id": "CHEBI:35896", "name": "CHEBI:35896", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478143", "map_id": "none", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_5693702", "map_id": "CHEBI:27958", "name": "COCN", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693711", "map_id": "CHEBI:17790", "name": "MeOH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_5693712", "map_id": "CHEBI:41001", "name": "BEG", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10478140", "map_id": "none", "name": "CES1 trimer, CES2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10479631", "map_id": "none", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_6784964", "map_id": "CHEBI:35854", "name": "VACV", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10479628", "map_id": "Q9VD00", "name": "Dmel\\CG5377", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "false" }, { "id": "FBgn0038974", "map_id": "FBgn0038974", "name": "Dmel\\CG5377", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478233", "map_id": "none", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_5694080", "map_id": "CHEBI:34560", "name": "BaP4,5O", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5694091", "map_id": "CHEBI:81621", "name": "BaP4,5-DHD", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10478230", "map_id": "Q7KB18", "name": "Jheh2", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0034405", "map_id": "FBgn0034405", "name": "Jheh2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10429084", "map_id": "none", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_30203", "map_id": "CHEBI:16236", "name": "EtOH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10429081", "map_id": "none", "name": "alcohol dehydrogenase complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10429112", "map_id": "none", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10429109", "map_id": "Q9VP61", "name": "AcCoAS", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10429094", "map_id": "none", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10479094", "map_id": "none", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "reaction_10477985", "map_id": "none", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5692221", "map_id": "CHEBI:48926", "name": "S-HMGSH", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5692249", "map_id": "CHEBI:16225", "name": "S-FGSH", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10477982", "map_id": "none", "name": "ADH5:2xZn2+ dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10492075", "map_id": "none", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8936443", "map_id": "CHEBI:47823", "name": "NOHA", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10492072", "map_id": "none", "name": "MARC1:Mo-MPT:MARC2:Mo-MPT:CYB5B:CYB5R3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17906", "compartment_display": "mitochondrial outer membrane", "complex": "true" }, { "id": "A1Z803", "map_id": "A1Z803", "name": "Marc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033451", "map_id": "FBgn0033451", "name": "Marc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:21437", "map_id": "CHEBI:21437", "name": "CHEBI:21437", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10492235", "map_id": "none", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10492232", "map_id": "none", "name": "Homologues of CES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465054", "map_id": "none", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2161525", "map_id": "none", "name": "abacavir", "type": "reactant", "sub_type": "other", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10465051", "map_id": "none", "name": "SLC22A1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10455658", "map_id": "none", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10455655", "map_id": "none", "name": "GABR heteropentamers:GABA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8SWZ1", "map_id": "Q8SWZ1", "name": "CT23391", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033558", "map_id": "FBgn0033558", "name": "CT23391", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q08832", "map_id": "Q08832", "name": "Lcch3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010240", "map_id": "FBgn0010240", "name": "Lcch3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25123", "map_id": "P25123", "name": "Rdl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004244", "map_id": "FBgn0004244", "name": "Rdl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXL9", "map_id": "Q9VXL9", "name": "Lcch-14A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030707", "map_id": "FBgn0030707", "name": "Lcch-14A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q24352", "map_id": "Q24352", "name": "Grd", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001134", "map_id": "FBgn0001134", "name": "Grd", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455765", "map_id": "none", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10455762", "map_id": "none", "name": "GABRR pentamers:GABA", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10435001", "map_id": "none", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434995", "map_id": "Q07327", "name": "Rop", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10434998", "map_id": "Q07327", "name": "phospho-Rop", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10434975", "map_id": "none", "name": "Activated conventional protein kinase C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10452783", "map_id": "none", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10452699", "map_id": "none", "name": "Platelet dense granule content", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114524", "compartment_display": "platelet dense granule lumen", "complex": "true" }, { "id": "Q9VKY4", "map_id": "Q9VKY4", "name": "Dmel\\CG5367", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032228", "map_id": "FBgn0032228", "name": "Dmel\\CG5367", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K187", "map_id": "Q7K187", "name": "Tango10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030330", "map_id": "FBgn0030330", "name": "Tango10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10452781", "map_id": "none", "name": "Platelet dense granule content", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10452814", "map_id": "none", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10452802", "map_id": "none", "name": "Platelet dense granule membrane components", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane", "complex": "true" }, { "id": "species_10452812", "map_id": "none", "name": "Platelet dense granule membrane components", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444110", "map_id": "none", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10444102", "map_id": "none", "name": "PSAP,CHID1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "Q9VLS0", "map_id": "Q9VLS0", "name": "Dmel\\CG8460", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031996", "map_id": "FBgn0031996", "name": "Dmel\\CG8460", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10444108", "map_id": "none", "name": "PSAP,CHID1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10452605", "map_id": "none", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10452245", "map_id": "none", "name": "Platelet alpha granule contents", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114506", "compartment_display": "platelet alpha granule lumen", "complex": "true" }, { "id": "Q9VLU2", "map_id": "Q9VLU2", "name": "Tg", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031975", "map_id": "FBgn0031975", "name": "Tg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK28", "map_id": "Q9VK28", "name": "CT35580", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032479", "map_id": "FBgn0032479", "name": "CT35580", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SXT3", "map_id": "Q8SXT3", "name": "swi2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034262", "map_id": "FBgn0034262", "name": "swi2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK22", "map_id": "Q9VK22", "name": "kek4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032484", "map_id": "FBgn0032484", "name": "kek4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKG1", "map_id": "Q9VKG1", "name": "kek2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015400", "map_id": "FBgn0015400", "name": "kek2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D0IQL1", "map_id": "D0IQL1", "name": "Lrt", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034540", "map_id": "FBgn0034540", "name": "Lrt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJN8", "map_id": "Q9VJN8", "name": "Dmel\\CG18480", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028518", "map_id": "FBgn0028518", "name": "Dmel\\CG18480", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VK54", "map_id": "Q9VK54", "name": "kek1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015399", "map_id": "FBgn0015399", "name": "kek1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4D6K327", "map_id": "A0A4D6K327", "name": "haf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261509", "map_id": "FBgn0261509", "name": "haf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V430", "map_id": "Q9V430", "name": "kek3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028370", "map_id": "FBgn0028370", "name": "kek3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "O97365", "map_id": "O97365", "name": "phospho-SPARC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX97", "map_id": "Q9VX97", "name": "Dmel\\CG4880", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030803", "map_id": "FBgn0030803", "name": "Dmel\\CG4880", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7L4", "map_id": "Q9I7L4", "name": "MAGE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037481", "map_id": "FBgn0037481", "name": "MAGE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K1H0", "map_id": "Q7K1H0", "name": "CG6491", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052066", "map_id": "FBgn0052066", "name": "CG6491", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SWU7", "map_id": "Q8SWU7", "name": "OLA1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030151", "map_id": "FBgn0030151", "name": "OLA1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q960F7", "map_id": "Q960F7", "name": "CG 2017", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037391", "map_id": "FBgn0037391", "name": "CG 2017", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VN86", "map_id": "Q9VN86", "name": "Sccpdh1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037298", "map_id": "FBgn0037298", "name": "Sccpdh1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W5T4", "map_id": "Q9W5T4", "name": "anon-EST:Posey268", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250830", "map_id": "FBgn0250830", "name": "anon-EST:Posey268", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0A0", "map_id": "Q9W0A0", "name": "phospho-drpr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VEY5", "map_id": "Q9VEY5", "name": "Dmel\\CG5903", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038400", "map_id": "FBgn0038400", "name": "Dmel\\CG5903", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10452603", "map_id": "none", "name": "Platelet alpha granule contents", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10453019", "map_id": "none", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10452947", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7JVP4", "map_id": "Q7JVP4", "name": "Br140", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033155", "map_id": "FBgn0033155", "name": "Br140", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VU68", "map_id": "Q9VU68", "name": "flr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260049", "map_id": "FBgn0260049", "name": "flr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9XZ63", "map_id": "Q9XZ63", "name": "Manf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0027095", "map_id": "FBgn0027095", "name": "Manf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V426", "map_id": "Q9V426", "name": "vig", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024183", "map_id": "FBgn0024183", "name": "vig", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "D2A6L8", "map_id": "D2A6L8", "name": "FDY", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0265047", "map_id": "FBgn0265047", "name": "FDY", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VED6", "map_id": "Q9VED6", "name": "Dmel\\CG7794", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038565", "map_id": "FBgn0038565", "name": "Dmel\\CG7794", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10453017", "map_id": "none", "name": "Platelet releasate cytosolic proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10452903", "map_id": "none", "name": "Release of platelet secretory granule components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10452899", "map_id": "Q9VWV6", "name": "Tsf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_1462052", "compartment_display": "secretory granule lumen", "complex": "false" }, { "id": "species_10452901", "map_id": "Q9VWV6", "name": "Tsf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10452882", "map_id": "none", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10452858", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_114510", "compartment_display": "platelet alpha granule membrane", "complex": "true" }, { "id": "Q961B9", "map_id": "Q961B9", "name": "LD24073p", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036579", "map_id": "FBgn0036579", "name": "LD24073p", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VZN0", "map_id": "Q9VZN0", "name": "CG12604", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052264", "map_id": "FBgn0052264", "name": "CG12604", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0X9", "map_id": "Q9W0X9", "name": "CT12588", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035085", "map_id": "FBgn0035085", "name": "CT12588", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VID1", "map_id": "Q9VID1", "name": "Tsp39D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032943", "map_id": "FBgn0032943", "name": "Tsp39D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFH5", "map_id": "Q9VFH5", "name": "Cad88C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038247", "map_id": "FBgn0038247", "name": "Cad88C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGG5", "map_id": "Q9VGG5", "name": "Cad87A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037963", "map_id": "FBgn0037963", "name": "Cad87A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10452880", "map_id": "none", "name": "Platelet alpha granule membrane components that are released on degranulation", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10448864", "map_id": "none", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane" }, { "id": "species_114565", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_114524", "compartment_display": "platelet dense granule lumen", "complex": "false" }, { "id": "species_10448861", "map_id": "Q9VLN6", "name": "Dme_CG7627", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_114584", "compartment_display": "platelet dense granule membrane", "complex": "false" }, { "id": "reaction_10434977", "map_id": "none", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10434959", "map_id": "none", "name": "Protein Kinase C, conventional", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10457707", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457703", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_927893", "compartment_display": "endoplasmic reticulum quality control compartment", "complex": "true" }, { "id": "species_10457705", "map_id": "none", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10443664", "map_id": "none", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_265479", "map_id": "CHEBI:49040", "name": "EZE", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10443660", "map_id": "none", "name": "Homologues of NPC1L1-1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VRC9", "map_id": "Q9VRC9", "name": "Npc1b", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261675", "map_id": "FBgn0261675", "name": "Npc1b", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VL24", "map_id": "Q9VL24", "name": "Npc1a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024320", "map_id": "FBgn0024320", "name": "Npc1a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10443662", "map_id": "none", "name": "NPC1L1:ezetimibe complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10439533", "map_id": "none", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189049", "map_id": "CHEBI:15824", "name": "Fru", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10439530", "map_id": "Q8IRI6", "name": "Glut1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10439540", "map_id": "none", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_189246", "map_id": "none", "name": "Fru, Gal, Glc", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_189219", "map_id": "none", "name": "Fru, Gal, Glc", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_209376", "map_id": "none", "name": "SPN27A binds to and inhibits EA protease activity", "reversible": "false", "notes": "In dorsoventral patterning, the serpin SPN27A binds to Easter (EA) serine protease. This complex inhibits Spatzle (SPZ) dimer processing.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_205912", "map_id": "P13582", "name": "EA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_206231", "map_id": "Q9V3N1", "name": "SPN27A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_206652", "map_id": "none", "name": "EA:SPN27A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_209141", "map_id": "none", "name": "ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane", "reversible": "false", "notes": "On binding to the Toll (TL) receptor ectodomain, Spatzle (SPZ) dimer sheds its Pro-domains. The SPZ dimer binds to the TL ectodomain at its N-terminus.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_206793", "map_id": "none", "name": "ProSPZ:SPZ dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_206218", "map_id": "P08953", "name": "TL", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_205949", "map_id": "P48607", "name": "ProSPZ", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_206655", "map_id": "none", "name": "SPZ dimer:TL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209076", "map_id": "none", "name": "SPZ dimer bound TL dimerises at the plasma membrane", "reversible": "false", "notes": "The binding of a Spatzle (SPZ) dimer to the N-terminus of the Toll (TL) receptor ectodomain triggers a conformational change in TL. This results in two discrete regions of the TL receptor ectodomains, one near the N-terminus and the other in the juxtamembrane region, to interact, inducing dimerisation and forming a 2:2 complex. The transmembrane segments of the receptor chains will be forced into close proximity forming additional favourable interactions which stabilise the dimer.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_206637", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_209156", "map_id": "none", "name": "MYD88 binds to TUB", "reversible": "false", "notes": "In close proximity to the plasma membrane, the adaptor proteins MYD88 and Tube (TUB) bind together through their death domains.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206015", "map_id": "Q7K105", "name": "MYD88", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206155", "map_id": "P22812", "name": "TUB", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_206621", "map_id": "none", "name": "MYD88:TUB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_214891", "map_id": "none", "name": "Full-length GD is cleaved by an unknown protease", "reversible": "false", "notes": "During early embryonic patterning, Toll (TL) is required for establishing the dorsoventral axis. The TL signal is initiated by activation of its ligand Spatzle (SPZ) by a serine protease cascade. Activation of this cascade is regulated by the probable chaperone protein Windbeutel (WBL) and by Pipe (PIP), a heparan-sulphanotransferase that has been proposed to create a heparin-modified proteoglycan that is required for local activation of the cascade. PIP is the only dorsoventral factor to be expressed on the ventral side of the embryo and is thought to be the key in activating the cascade. The full-length serine protease zymogen, Gastrulation Defective (GD) is cleaved between Arg136 and Lys137. This separates the inhibitory prodomain from the now active mature enzyme. How GD is activated remains uncertain, although a direct interaction with Nudel (NDL) or autoproteolytic processing cannot be ruled out.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_214753", "map_id": "O62589", "name": "GD full-length", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_214276", "map_id": "O62589", "name": "GD", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_214754", "map_id": "O62589", "name": "ProGD", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_214274", "map_id": "none", "name": "unknown protein", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_209130", "map_id": "none", "name": "Full-length SPZ dimer is cleaved by EA/SPE serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the trypsin-like serine protease Easter (EA) is known to cleave full-length Spatzle (SPZ) dimer between residues Arg220 and Val221. This frees the Pro-domain and the C-terminal SPZ dimer aka C-106. In the innate immunity response, the serine protease cleavage enzyme is the Spatzle-processing enzyme aka SPE (CG16705). The Pro-domains and the SPZ dimer remain associated after cleavage.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_206598", "map_id": "none", "name": "SPZ full-length dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_206576", "map_id": "none", "name": "EA/SPE", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "Q9VCJ8", "map_id": "Q9VCJ8", "name": "SPE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "SPE", "map_id": "SPE", "name": "SPE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_214953", "map_id": "none", "name": "Full-length SNK is cleaved by GD serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the full-length serine protease zymogen, Snake (SNK), is cleaved by active Gastrulation Defective (GD) serine protease between residues Leu185 and Ile186. The removal of the prodomain results in an active SNK protease.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_214747", "map_id": "P05049", "name": "SNK full-length", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_214750", "map_id": "P05049", "name": "ProSNK", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_214280", "map_id": "P05049", "name": "SNK", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_214853", "map_id": "none", "name": "WEK and MYD88:TUB bind to the TL receptor", "reversible": "false", "notes": "Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homodimerisation and activation. In dorsoventral patterning in Drosophila embryos, the zinc finger containing adaptor protein Weckle, (WEK) binds to both the TL receptor cytoplasmic domain and the adaptor protein MYD88, which in complex with Tube (TUB), also binds to TL. In addition, WEK forms dimers through its N-terminal region.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_214745", "map_id": "Q9VJN5", "name": "WEK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_209100", "map_id": "none", "name": "MYD88:TUB binds to TL receptor", "reversible": "false", "notes": "Upon Spatzle (SPZ) dimer binding, leading to Toll (TL) receptor homodimerisation and activation, MYD88:TUB complex binds to the endoplasmic Toll/Interleukin-1 receptor (TIR) domain of TL receptor at the plasma membrane.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_214956", "map_id": "none", "name": "Full-length EA is cleaved by SNK serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the full-length serine protease zymogen, Easter (EA) is cleaved by active serine protease, Snake (SNK), between residues Arg127 and Ile128. The removal of the inhibitory prodomain results in an active EA serine protease.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_214751", "map_id": "P13582", "name": "EA full-length", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_214755", "map_id": "P13582", "name": "ProEA", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_214871", "map_id": "none", "name": "Phosphorylated CACT is degraded in the cytosol", "reversible": "false", "notes": "In humans, the Cactus (CACT) orthologue IkappaB is polyubiquitinated by the beta-TrCP E3 ubiquitin ligase containing complex. This marks it for degradation by the 26S proteosome. It is believed that CACT is degraded in a similar manner, however, a Drosophila E3 ubiquitin ligase that acts in the Toll pathway has yet to be identified. The obvious candidate, the closest beta-TrCP orthologue Slimb (SLMB) has produced contradictory evidence on whether it participates in the Toll pathway (Spencer et al., 1999; Leulier et al., 2003).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_214741", "map_id": "none", "name": "Phospho DL/DIF dimer:Phospho CACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_214864", "map_id": "none", "name": "Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Once phosphorylated, Cactus (CACT), in complex with the Dorsal/Dorsal-related immunity factor (DL/DIF) homodimer, dissociates from the Toll (TL) receptor 'signalling complex'.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_214748", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:Phospho DL/DIF dimer:Phospho CACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_214847", "map_id": "none", "name": "Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Once phosphorylated, Cactus (CACT), in complex with the Dorsal (DL) homodimer, dissociates from the Toll (TL) receptor 'signalling complex'.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_214749", "map_id": "none", "name": "SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:Phospho DL dimer:Phospho CACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_214752", "map_id": "none", "name": "Phospho DL dimer:Phospho CACT", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_209057", "map_id": "none", "name": "Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "On binding to the 'signalling complex', the Ser/Thr kinase Pelle (PLL) is activated and autophosphorylates.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_214859", "map_id": "none", "name": "Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "On binding to the 'signalling complex', the Ser/Thr kinase Pelle (PLL) is activated and autophosphorylates.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_214845", "map_id": "none", "name": "CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Pelle (PLL) may be the kinase that phosphorylates both Cactus (CACT) and the Dorsal (DL) homodimer but the biochemical evidence for this is currently inconclusive. CACT is phosphorylated in its N-terminal half within the first 125 residues. In this region, there are two IKK target-like motifs, involving Ser74 and Ser78 in one, and Ser116 in the other. However, it is not clear which of these residues need to be phosphorylated. DL homodimer is phosphorylated at both Ser317 residues while associated with CACT.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_206306", "map_id": "none", "name": "unknown kinase", "type": "catalyst", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_214860", "map_id": "none", "name": "CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Pelle (PLL) may be the kinase that phosphorylates both Cactus (CACT) and the Dorsal/Dorsal-related immunity factor (DL/DIF) homodimer but the biochemical evidence for this is currently inconclusive. DL/DIF homodimer is phosphorylated while associated with CACT. DL is phosphorylated on Ser317 while DIF is very likely to be phosphorylated at Ser348 (inferred from DL). CACT is phosphorylated in its N-terminal half within the first 125 residues. In this region, there are two IKK target-like motifs, involving Ser74 and Ser78 in one, and Ser116 in the other. However, it is not clear which of these residues need to be phosphorylated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10466911", "map_id": "none", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10466905", "map_id": "P00528", "name": "Src64B", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10466908", "map_id": "P00528", "name": "phospho-Src64B", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10441884", "map_id": "none", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_202277", "map_id": "none", "name": "PIP3, PI(3,4)P2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10441882", "map_id": "none", "name": "PDK1:PIP2,PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466859", "map_id": "none", "name": "PI3K associates with phosphorylated GAB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10466855", "map_id": "none", "name": "p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10466857", "map_id": "none", "name": "p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466946", "map_id": "none", "name": "Phosphorylation of PIP2 to PIP3 by PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10466861", "map_id": "none", "name": "Interaction of GRB2:SOS complex with p-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10465768", "map_id": "Q9V3C8", "name": "phospho-Shc", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465770", "map_id": "none", "name": "p-SHC1:GRB2:SOS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10466844", "map_id": "none", "name": "Phosphorylation and activation of VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10466842", "map_id": "none", "name": "p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10466835", "map_id": "none", "name": "p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466840", "map_id": "none", "name": "Activation of RAC1 by VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10466837", "map_id": "none", "name": "p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466952", "map_id": "none", "name": "Recruitment of PAK to the membrane by binding active RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10466884", "map_id": "none", "name": "PAK dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10466886", "map_id": "none", "name": "p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466903", "map_id": "none", "name": "Autophosphorylation of BTK/ITK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10466826", "map_id": "none", "name": "p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "P08630", "map_id": "P08630", "name": "Btk29A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10466900", "map_id": "none", "name": "p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10466871", "map_id": "none", "name": "Hydrolysis of PIP2 by PLCG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10466868", "map_id": "none", "name": "p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10477775", "map_id": "none", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477766", "map_id": "none", "name": "UCHL3,SENP8:NEDD8(1-88)", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VRE9", "map_id": "Q9VRE9", "name": "Dmel\\CG1503", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031157", "map_id": "FBgn0031157", "name": "Dmel\\CG1503", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJ33", "map_id": "Q9VJ33", "name": "Nedd8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477770", "map_id": "none", "name": "UCHL3,SENP8:NEDD8", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10477772", "map_id": "Q9VJ33", "name": "Nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10475484", "map_id": "none", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475473", "map_id": "Q9XZ61", "name": "Uch-L5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10475482", "map_id": "none", "name": "ADRM1:26S proteasome:UCHL5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10477752", "map_id": "none", "name": "BAP1 binds Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477180", "map_id": "Q7K5N4", "name": "calypso", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0262166", "map_id": "FBgn0262166", "name": "calypso", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477741", "map_id": "Q9V4C8", "name": "Hcf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0039904", "map_id": "FBgn0039904", "name": "Hcf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477743", "map_id": "none", "name": "BAP1:K48polyUb,K63polyUb-HCFC1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9V4C8", "map_id": "Q9V4C8", "name": "Hcf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K5N4", "map_id": "Q7K5N4", "name": "calypso", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10477720", "map_id": "none", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477715", "map_id": "none", "name": "UCHL1,UCHL3:Ub-Lys", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_1131871", "map_id": "CHEBI:32551", "name": "L-lysine", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_459", "compartment_display": "cytoplasm", "complex": "false" }, { "id": "species_10477717", "map_id": "none", "name": "UCHL1,UCHL3:Ub", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10477175", "map_id": "none", "name": "UCHL5 binds INO80 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477171", "map_id": "Q9XZ61", "name": "Uch-L5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10477173", "map_id": "none", "name": "UCHL5:INO80 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10477750", "map_id": "none", "name": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477745", "map_id": "none", "name": "BAP1:HCFC1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10477747", "map_id": "none", "name": "K48-polyUb, K63-polyUb", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10475507", "map_id": "none", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475478", "map_id": "Q7K2G1", "name": "Rpn13", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10477216", "map_id": "none", "name": "BAP1 binds BAP1-interacting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10477212", "map_id": "none", "name": "BAP1-interacting complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q7KJA9", "map_id": "Q7KJA9", "name": "sxc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261403", "map_id": "FBgn0261403", "name": "sxc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PF47", "map_id": "M9PF47", "name": "FoxK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036134", "map_id": "FBgn0036134", "name": "FoxK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3Q5", "map_id": "Q9W3Q5", "name": "CHES-1-like", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029504", "map_id": "FBgn0029504", "name": "CHES-1-like", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V727", "map_id": "Q9V727", "name": "Asx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261823", "map_id": "FBgn0261823", "name": "Asx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477214", "map_id": "none", "name": "BAP1:BAP1-interacting complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10455103", "map_id": "none", "name": "apoTF binds 2Fe3+ to form holoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_912516", "map_id": "CHEBI:29034", "name": "Fe3+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10455101", "map_id": "none", "name": "holoTF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10477961", "map_id": "none", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477840", "map_id": "none", "name": "Homologues of IREB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VGZ3", "map_id": "Q9VGZ3", "name": "Irp-1B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024957", "map_id": "FBgn0024957", "name": "Irp-1B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VCV4", "map_id": "Q9VCV4", "name": "Irp-1A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024958", "map_id": "FBgn0024958", "name": "Irp-1A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10477952", "map_id": "none", "name": "Homologues of Ub-K-IREB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10477958", "map_id": "none", "name": "SKP1:FBXL5:CUL1:NEDD8", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10477944", "map_id": "none", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix" }, { "id": "species_5691135", "map_id": "CHEBI:78619", "name": "Fe(3+)O(OH)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10477941", "map_id": "none", "name": "FTMT 24mer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "true" }, { "id": "reaction_10477831", "map_id": "none", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477827", "map_id": "Q9VGZ3", "name": "Irp-1B", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5690881", "map_id": "none", "name": "4Fe-4S", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10477829", "map_id": "none", "name": "ACO1:4Fe-4S", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10477845", "map_id": "none", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_389545", "map_id": "CHEBI:151", "name": "ISCIT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10455096", "map_id": "none", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "reaction_10455111", "map_id": "none", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_917810", "map_id": "CHEBI:29033", "name": "Fe2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_171907", "compartment_display": "endosome lumen", "complex": "false" }, { "id": "species_10455108", "map_id": "Q9VW35", "name": "Trpml", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "false" }, { "id": "reaction_10459940", "map_id": "none", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5691103", "map_id": "CHEBI:78619", "name": "Fe(3+)O(OH)", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10477970", "map_id": "none", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477966", "map_id": "Q9VKY2", "name": "Cand1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10477968", "map_id": "none", "name": "CANDI:CUL1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10493560", "map_id": "none", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_8949232", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_8949220", "map_id": "CHEBI:29108", "name": "Ca2+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10493557", "map_id": "none", "name": "MCU complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q7JX57", "map_id": "Q7JX57", "name": "EMRE", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0062440", "map_id": "FBgn0062440", "name": "EMRE", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQ70", "map_id": "Q8IQ70", "name": "MCU", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042185", "map_id": "FBgn0042185", "name": "MCU", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A2VEI2", "map_id": "A2VEI2", "name": "MICU1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031893", "map_id": "FBgn0031893", "name": "MICU1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493619", "map_id": "none", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10493605", "map_id": "none", "name": "proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q9W0X3", "map_id": "Q9W0X3", "name": "DmP29", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035088", "map_id": "FBgn0035088", "name": "DmP29", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W4W8", "map_id": "Q9W4W8", "name": "Spg7", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024992", "map_id": "FBgn0024992", "name": "Spg7", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "F3YDF1", "map_id": "F3YDF1", "name": "YME1L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034792", "map_id": "FBgn0034792", "name": "YME1L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8T4G5", "map_id": "Q8T4G5", "name": "AFG3L2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036702", "map_id": "FBgn0036702", "name": "AFG3L2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P24156", "map_id": "P24156", "name": "l(2)37Cc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYI6", "map_id": "A8DYI6", "name": "Phb2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010551", "map_id": "FBgn0010551", "name": "Phb2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493607", "map_id": "Q7JX57", "name": "EMRE", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10493553", "map_id": "Q7JX57", "name": "EMRE", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "species_10493601", "map_id": "none", "name": "C2orf47:AFG3L2:SPG7:PHB:PHB2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "species_10493616", "map_id": "none", "name": "Mitochondrial processing peptidase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "true" }, { "id": "Q7K3W2", "map_id": "Q7K3W2", "name": "CG8728-RA", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033235", "map_id": "FBgn0033235", "name": "CG8728-RA", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493622", "map_id": "none", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "reaction_10493624", "map_id": "none", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_10493603", "map_id": "Q7JX57", "name": "EMRE", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10493629", "map_id": "none", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane" }, { "id": "species_2889072", "map_id": "CHEBI:29101", "name": "Na+", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17927", "compartment_display": "mitochondrial intermembrane space", "complex": "false" }, { "id": "species_2889083", "map_id": "CHEBI:29101", "name": "Na+", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_5460", "compartment_display": "mitochondrial matrix", "complex": "false" }, { "id": "species_10493626", "map_id": "A1Z7I1", "name": "Dmel\\CG14744", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70616", "compartment_display": "mitochondrial inner membrane", "complex": "false" }, { "id": "reaction_10471663", "map_id": "none", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471660", "map_id": "Q8SY53", "name": "Ostgamma", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10471086", "map_id": "none", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471077", "map_id": "none", "name": "ADD1:ADD2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10471082", "map_id": "E1JIH3", "name": "Unc-115a", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0051352", "map_id": "FBgn0051352", "name": "Unc-115a", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471084", "map_id": "none", "name": "ADD1:ADD2:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "E1JIH3", "map_id": "E1JIH3", "name": "Unc-115a", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471094", "map_id": "none", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471090", "map_id": "none", "name": "ADD1:ADD3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10471092", "map_id": "none", "name": "ADD1:ADD3:DMTN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10471636", "map_id": "none", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471627", "map_id": "M9PD12", "name": "spict", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0032451", "map_id": "FBgn0032451", "name": "spict", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471650", "map_id": "none", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471647", "map_id": "Q8SY53", "name": "Ostgamma", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10493197", "map_id": "none", "name": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8941540", "map_id": "none", "name": "I-, Cl-", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8941541", "map_id": "none", "name": "I-, Cl-", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10493194", "map_id": "none", "name": "VRAC heteromer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453114", "map_id": "none", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10453109", "map_id": "none", "name": "AQP0,1,2,3,4,5,7,8,9,10,11,12A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453112", "map_id": "none", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10479551", "map_id": "none", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10479517", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q7YU01", "map_id": "Q7YU01", "name": "LpR2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051092", "map_id": "FBgn0051092", "name": "LpR2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10479549", "map_id": "none", "name": "PCSK9:LDLR:Clathrin:AP2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane", "complex": "true" }, { "id": "reaction_10491346", "map_id": "none", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "species_10491342", "map_id": "Q9VL24", "name": "Npc1a", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "false" }, { "id": "species_10491338", "map_id": "none", "name": "NPC2:CHOL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10491336", "map_id": "none", "name": "Homologues of NPC2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen", "complex": "true" }, { "id": "species_10491344", "map_id": "none", "name": "NPC1:CHOL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17938", "compartment_display": "lysosomal membrane", "complex": "true" }, { "id": "reaction_10491348", "map_id": "none", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10491412", "map_id": "none", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_8876704", "map_id": "CHEBI:17002", "name": "CHEST", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "species_10491407", "map_id": "Q8MYW9", "name": "ACAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0037612", "map_id": "FBgn0037612", "name": "ACAT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10491340", "map_id": "none", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_161320", "compartment_display": "lysosomal lumen" }, { "id": "reaction_10437938", "map_id": "none", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_74700", "compartment_display": "endosome membrane" }, { "id": "species_10437930", "map_id": "none", "name": "Homologues of LDLR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74700", "compartment_display": "endosome membrane", "complex": "true" }, { "id": "species_10437936", "map_id": "none", "name": "Homologues of LDLR", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10479553", "map_id": "none", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1660541", "compartment_display": "endolysosome membrane" }, { "id": "species_10479547", "map_id": "none", "name": "Clathrin:AP2 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_24339", "compartment_display": "clathrin-coated endocytic vesicle membrane", "complex": "true" }, { "id": "reaction_10490897", "map_id": "none", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1131164", "map_id": "CHEBI:48861", "name": "geranylgeranyl diphosphate", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10490631", "map_id": "none", "name": "RGGT:CHMs:RABs:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10490894", "map_id": "none", "name": "RGGTA:RGGTB:GGPP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10490892", "map_id": "none", "name": "CHMs:GGC-RABs:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10490498", "map_id": "none", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10490490", "map_id": "none", "name": "RABGGTA:RABGGTB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10490496", "map_id": "none", "name": "RABGGTA:RABGGTB:CHMs:GGPP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10490633", "map_id": "none", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10490629", "map_id": "none", "name": "RABs:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10490492", "map_id": "none", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10490488", "map_id": "Q9XZ68", "name": "betaggt-II", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10490486", "map_id": "Q9VN77", "name": "RabGGTalpha", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10468651", "map_id": "none", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468647", "map_id": "none", "name": "HSP40:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VFV9", "map_id": "Q9VFV9", "name": "Droj2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038145", "map_id": "FBgn0038145", "name": "Droj2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PD23", "map_id": "M9PD23", "name": "DnaJ-H", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032474", "map_id": "FBgn0032474", "name": "DnaJ-H", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468649", "map_id": "none", "name": "HSP70:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10468516", "map_id": "none", "name": "HSP40:HSP70:ATP:nascent protein", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10468521", "map_id": "none", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468518", "map_id": "none", "name": "HSP40:HSP70:ADP:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10468514", "map_id": "none", "name": "HSP40s", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498696", "map_id": "none", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8979218", "map_id": "none", "name": "Androgens", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10473503", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:SHR", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10498694", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:AR:Androgens", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498553", "map_id": "none", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473346", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:NR3C1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_5618094", "map_id": "none", "name": "SH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10473348", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:NR3C1:SH", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10498474", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:NR3C1:NR3C1 agonists", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10468612", "map_id": "none", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468600", "map_id": "Q9VPN5", "name": "Stip1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0024352", "map_id": "FBgn0024352", "name": "Stip1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10468604", "map_id": "none", "name": "HSP90:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10468610", "map_id": "none", "name": "HSP90:STIP1:HSP70:nascent protein", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VPN5", "map_id": "Q9VPN5", "name": "Stip1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10473507", "map_id": "none", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473495", "map_id": "none", "name": "HSP90:ATP:STIP1:HSP70:nascent protein", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10498476", "map_id": "none", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_9678859", "map_id": "none", "name": "NR3C1 agonists", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10473490", "map_id": "none", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10473342", "map_id": "none", "name": "HSP90:ATP:FKBP4:PTGES3:SHR:SH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10473360", "map_id": "none", "name": "HSP90:ATP:PTGES3:FKBP52:SHR:SH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10473364", "map_id": "none", "name": "HSP90:ATP:PTGES3:FKBP52:NR3C1:SH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10473505", "map_id": "none", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10498428", "map_id": "none", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10427600", "map_id": "Q9VKW3", "name": "RfC3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10438451", "map_id": "none", "name": "CTF18 complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q2PDX2", "map_id": "Q2PDX2", "name": "Dmel\\CG34001", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0054001", "map_id": "FBgn0054001", "name": "Dmel\\CG34001", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IQ05", "map_id": "Q8IQ05", "name": "cutlet", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015376", "map_id": "FBgn0015376", "name": "cutlet", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q4V3Z5", "map_id": "Q4V3Z5", "name": "Dmel\\CG11788", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034495", "map_id": "FBgn0034495", "name": "Dmel\\CG11788", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10427605", "map_id": "Q9VX15", "name": "Rfc37", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427610", "map_id": "Q9U9Q1", "name": "RfC38", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10427615", "map_id": "P53034", "name": "RfC4", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10438453", "map_id": "none", "name": "CTF18-RFC(7s) complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10498430", "map_id": "none", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10438449", "map_id": "Q4V3Z5", "name": "Dmel\\CG11788", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10438439", "map_id": "Q8IQ05", "name": "cutlet", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10438444", "map_id": "Q2PDX2", "name": "Dmel\\CG34001", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10442443", "map_id": "none", "name": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442429", "map_id": "Q9GU68", "name": "eEF5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0285952", "map_id": "FBgn0285952", "name": "eEF5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_204628", "map_id": "CHEBI:15725", "name": "1,3-diaminopropane", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442425", "map_id": "Q9GU68", "name": "eEF5", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442438", "map_id": "none", "name": "DHPS tetramer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSF4", "map_id": "Q9VSF4", "name": "DHPS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035854", "map_id": "FBgn0035854", "name": "DHPS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10442458", "map_id": "none", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442446", "map_id": "Q9GU68", "name": "eEF5", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442455", "map_id": "none", "name": "DOHH:Fe++", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V9U4", "map_id": "Q9V9U4", "name": "nero", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261479", "map_id": "FBgn0261479", "name": "nero", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445932", "map_id": "none", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10445921", "map_id": "Q9NIV1", "name": "PEK", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0037327", "map_id": "FBgn0037327", "name": "PEK", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445930", "map_id": "none", "name": "PERK dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9NIV1", "map_id": "Q9NIV1", "name": "PEK", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445957", "map_id": "none", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445954", "map_id": "none", "name": "p-S52-EIF2S1:EIF2S2:EIF2S3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10476175", "map_id": "none", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5687536", "map_id": "CHEBI:85309", "name": "isoAsp", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_5687529", "map_id": "CHEBI:31882", "name": "MetAsp", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10476172", "map_id": "Q27869", "name": "Pcmt", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0086768", "map_id": "FBgn0086768", "name": "Pcmt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10476167", "map_id": "none", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5676932", "map_id": "CHEBI:49032", "name": "L-methionine (R)-S-oxide", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10476162", "map_id": "Q8INK9", "name": "SelR", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0267376", "map_id": "FBgn0267376", "name": "SelR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10461449", "map_id": "none", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10461443", "map_id": "none", "name": "Signal Recognition Particle", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSS2", "map_id": "Q9VSS2", "name": "Srp68", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035947", "map_id": "FBgn0035947", "name": "Srp68", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P49963", "map_id": "P49963", "name": "Srp19", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015298", "map_id": "FBgn0015298", "name": "Srp19", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSC1", "map_id": "Q9VSC1", "name": "Srp9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035827", "map_id": "FBgn0035827", "name": "Srp9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDK7", "map_id": "Q9VDK7", "name": "Srp72", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038810", "map_id": "FBgn0038810", "name": "Srp72", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3D9", "map_id": "Q9V3D9", "name": "Srp54k", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0010747", "map_id": "FBgn0010747", "name": "Srp54k", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10461445", "map_id": "none", "name": "ribosome:mRNA:polypeptide+signal", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10461447", "map_id": "none", "name": "SRP:polypeptide+signal:ribosome", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10494849", "map_id": "none", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493819", "map_id": "none", "name": "DCUN1Ds", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VUQ8", "map_id": "Q9VUQ8", "name": "DCUN1D1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036510", "map_id": "FBgn0036510", "name": "DCUN1D1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10494824", "map_id": "none", "name": "CRL1 E3 ubiquitin ligase:COMMDs:CCDC22", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VVB4", "map_id": "Q9VVB4", "name": "CCDC22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036671", "map_id": "FBgn0036671", "name": "CCDC22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10493698", "map_id": "none", "name": "NEDD8-AcM-UBE2M", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VSF3", "map_id": "Q9VSF3", "name": "UbcE2M", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035853", "map_id": "FBgn0035853", "name": "UbcE2M", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10494826", "map_id": "none", "name": "NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495201", "map_id": "none", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495188", "map_id": "none", "name": "NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VMR4", "map_id": "Q9VMR4", "name": "nompC", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0016920", "map_id": "FBgn0016920", "name": "nompC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUW0", "map_id": "Q9VUW0", "name": "Dmel\\CG10516", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036549", "map_id": "FBgn0036549", "name": "Dmel\\CG10516", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VQI1", "map_id": "Q9VQI1", "name": "Dmel\\CG3104", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031473", "map_id": "FBgn0031473", "name": "Dmel\\CG3104", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VA06", "map_id": "Q9VA06", "name": "stops", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086704", "map_id": "FBgn0086704", "name": "stops", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W112", "map_id": "Q9W112", "name": "Dmel\\CG3894", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035059", "map_id": "FBgn0035059", "name": "Dmel\\CG3894", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZBY1", "map_id": "A1ZBY1", "name": "Fem-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034542", "map_id": "FBgn0034542", "name": "Fem-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8INY1", "map_id": "Q8INY1", "name": "Socs36E", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0041184", "map_id": "FBgn0041184", "name": "Socs36E", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAQ0", "map_id": "Q9VAQ0", "name": "Cul5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JWH5", "map_id": "Q7JWH5", "name": "Roc2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0044020", "map_id": "FBgn0044020", "name": "Roc2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VDH3", "map_id": "Q9VDH3", "name": "Ktl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038839", "map_id": "FBgn0038839", "name": "Ktl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUU5", "map_id": "Q9VUU5", "name": "dbo", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0040230", "map_id": "FBgn0040230", "name": "dbo", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P05084", "map_id": "P05084", "name": "hb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001180", "map_id": "FBgn0001180", "name": "hb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VNZ4", "map_id": "Q9VNZ4", "name": "Dmel\\CG11247", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037120", "map_id": "FBgn0037120", "name": "Dmel\\CG11247", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JQX6", "map_id": "A8JQX6", "name": "Dmel\\CG4820", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037876", "map_id": "FBgn0037876", "name": "Dmel\\CG4820", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJL7", "map_id": "Q9VJL7", "name": "DS02740.8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028895", "map_id": "FBgn0028895", "name": "DS02740.8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1ZAV3", "map_id": "A1ZAV3", "name": "MESR4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034240", "map_id": "FBgn0034240", "name": "MESR4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHJ6", "map_id": "Q9VHJ6", "name": "ich", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0286204", "map_id": "FBgn0286204", "name": "ich", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K0L2", "map_id": "Q7K0L2", "name": "Dmel\\CG17754", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030114", "map_id": "FBgn0030114", "name": "Dmel\\CG17754", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A4D6K4X9", "map_id": "A0A4D6K4X9", "name": "axed", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035708", "map_id": "FBgn0035708", "name": "axed", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR80", "map_id": "Q9VR80", "name": "Dmel\\CG17068", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031098", "map_id": "FBgn0031098", "name": "Dmel\\CG17068", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q04652", "map_id": "Q04652", "name": "kel", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001301", "map_id": "FBgn0001301", "name": "kel", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VFD5", "map_id": "Q9VFD5", "name": "FEM1C", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038286", "map_id": "FBgn0038286", "name": "FEM1C", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7J2", "map_id": "Q9I7J2", "name": "m-cup", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0038488", "map_id": "FBgn0038488", "name": "m-cup", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495198", "map_id": "none", "name": "CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10477768", "map_id": "Q9VJ33", "name": "Nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10494949", "map_id": "none", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10494922", "map_id": "none", "name": "NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VAT2", "map_id": "Q9VAT2", "name": "DCAF10", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039601", "map_id": "FBgn0039601", "name": "DCAF10", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7K7W5", "map_id": "Q7K7W5", "name": "adp", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000057", "map_id": "FBgn0000057", "name": "adp", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9T1", "map_id": "Q9V9T1", "name": "CG2112", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0250755", "map_id": "FBgn0250755", "name": "CG2112", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IP73", "map_id": "Q8IP73", "name": "CG6537", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051855", "map_id": "FBgn0051855", "name": "CG6537", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W091", "map_id": "Q9W091", "name": "Dmel\\CG8001", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035268", "map_id": "FBgn0035268", "name": "Dmel\\CG8001", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q7JYQ4", "map_id": "Q7JYQ4", "name": "Dmel\\CG9945", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034527", "map_id": "FBgn0034527", "name": "Dmel\\CG9945", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR53", "map_id": "Q9VR53", "name": "wap", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266848", "map_id": "FBgn0266848", "name": "wap", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10494924", "map_id": "Q9VSF3", "name": "UbcE2M", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10494946", "map_id": "none", "name": "NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495238", "map_id": "none", "name": "NEDD8 and UBD bind NUB1 and the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495234", "map_id": "Q9VBQ3", "name": "Dmel\\CG5111", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0039343", "map_id": "FBgn0039343", "name": "Dmel\\CG5111", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495236", "map_id": "none", "name": "NEDD8,UBD:NUB1:26S proteasome", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VBQ3", "map_id": "Q9VBQ3", "name": "Dmel\\CG5111", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10494951", "map_id": "none", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10494920", "map_id": "none", "name": "DCUN1D1,2,4,5", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10494855", "map_id": "none", "name": "NEDD8-AcM-UBE2M", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10494912", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495208", "map_id": "none", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495205", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10495203", "map_id": "Q9VJ33", "name": "Nedd8", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10495240", "map_id": "none", "name": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10495242", "map_id": "none", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10494842", "map_id": "Q8T8S1", "name": "SCCRO3", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0033784", "map_id": "FBgn0033784", "name": "SCCRO3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10494844", "map_id": "none", "name": "CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8T8S1", "map_id": "Q8T8S1", "name": "SCCRO3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10493675", "map_id": "none", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10477759", "map_id": "none", "name": "UCHL3,SENP8", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495122", "map_id": "none", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495118", "map_id": "none", "name": "CRL E3 ubiquitin ligases", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10495120", "map_id": "none", "name": "CRL E3 ubiquitin ligase:CAND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495219", "map_id": "none", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495215", "map_id": "Q7K4I5", "name": "Dmel\\CG8892", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0031664", "map_id": "FBgn0031664", "name": "Dmel\\CG8892", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495210", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10495217", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q7K4I5", "map_id": "Q7K4I5", "name": "Dmel\\CG8892", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10495223", "map_id": "none", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495221", "map_id": "none", "name": "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495128", "map_id": "none", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10494894", "map_id": "none", "name": "RBX1:CUL4:DDB1:DCAFs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10495124", "map_id": "Q9VKY2", "name": "Cand1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10495126", "map_id": "none", "name": "CRL4 E3 ubiquitin ligase:CAND1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495228", "map_id": "none", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495225", "map_id": "none", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10494846", "map_id": "none", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493677", "map_id": "Q9VSF3", "name": "UbcE2M", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10494838", "map_id": "none", "name": "NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10489264", "map_id": "none", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8855720", "map_id": "CHEBI:37396", "name": "proteoglycan", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10489260", "map_id": "none", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10489262", "map_id": "none", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2:proteoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10488819", "map_id": "none", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8853371", "map_id": "none", "name": "unfolded protein:GlcNAc", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8853381", "map_id": "none", "name": "GlcNAc (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:91284", "map_id": "CHEBI:91284", "name": "CHEBI:91284", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91283", "map_id": "CHEBI:91283", "name": "CHEBI:91283", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91282", "map_id": "CHEBI:91282", "name": "CHEBI:91282", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:91281", "map_id": "CHEBI:91281", "name": "CHEBI:91281", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10488816", "map_id": "Q9VX51", "name": "Dmel\\CG5613", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0030839", "map_id": "FBgn0030839", "name": "Dmel\\CG5613", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10488392", "map_id": "none", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_1022114", "map_id": "none", "name": "unfolded protein", "type": "product", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_8852852", "map_id": "none", "name": "(GlcNAc)2 (Man)9-5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10488389", "map_id": "none", "name": "Deglycosylation complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q7KRR5", "map_id": "Q7KRR5", "name": "Pngl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0033050", "map_id": "FBgn0033050", "name": "Pngl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VSC5", "map_id": "Q9VSC5", "name": "anon-WO0172774.138", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035830", "map_id": "FBgn0035830", "name": "anon-WO0172774.138", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10454410", "map_id": "none", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10454406", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "P29413", "map_id": "P29413", "name": "Calr", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0005585", "map_id": "FBgn0005585", "name": "Calr", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7S9", "map_id": "Q9I7S9", "name": "Dmel\\CG1924", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030377", "map_id": "FBgn0030377", "name": "Dmel\\CG1924", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VXF6", "map_id": "Q9VXF6", "name": "Cnx14D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264077", "map_id": "FBgn0264077", "name": "Cnx14D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAL7", "map_id": "Q9VAL7", "name": "Cnx99A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015622", "map_id": "FBgn0015622", "name": "Cnx99A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:59080", "map_id": "CHEBI:59080", "name": "CHEBI:59080", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10453353", "map_id": "Q3YMU0", "name": "ERp60", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "FBgn0033663", "map_id": "FBgn0033663", "name": "ERp60", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10454408", "map_id": "none", "name": "unfolded protein:(Glc)1 (GlcNAc)2 (Man)9 (Asn)1:chaperone:ERp57", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "Q3YMU0", "map_id": "Q3YMU0", "name": "ERp60", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455485", "map_id": "none", "name": "Alternative endo-mannosidase I route", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17963", "compartment_display": "Golgi lumen" }, { "id": "species_964754", "map_id": "CHEBI:59084", "name": "(Glc)3 (GlcNAc)2 (Man)9 (Asn)1", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_964744", "map_id": "CHEBI:59089", "name": "(GlcNAc)2 (Man)8 (Asn)1", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10455482", "map_id": "Q9VMQ2", "name": "Dmel\\CG14015", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_20699", "compartment_display": "Golgi membrane", "complex": "false" }, { "id": "FBgn0031716", "map_id": "FBgn0031716", "name": "Dmel\\CG14015", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10455493", "map_id": "none", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10455490", "map_id": "Q60GL7", "name": "Mgat1", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_6791047", "compartment_display": "endoplasmic reticulum-Golgi intermediate compartment membrane", "complex": "false" }, { "id": "FBgn0034521", "map_id": "FBgn0034521", "name": "Mgat1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10478044", "map_id": "none", "name": "STAMBP binds STAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10439062", "map_id": "Q9XTL2", "name": "Stam", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10478040", "map_id": "Q9VA71", "name": "Q9VA71", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0039773", "map_id": "FBgn0039773", "name": "Q9VA71", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10478042", "map_id": "none", "name": "STAMBP:STAM", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VA71", "map_id": "Q9VA71", "name": "Q9VA71", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10479159", "map_id": "none", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10479156", "map_id": "Q9VA71", "name": "Q9VA71", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10477973", "map_id": "none", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10426995", "map_id": "Q9V3H2", "name": "Rpn11", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10435837", "map_id": "none", "name": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10435823", "map_id": "none", "name": "Homologues of F7(21-466)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_10435834", "map_id": "Q9W0C4", "name": "GC", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "FBgn0035245", "map_id": "FBgn0035245", "name": "GC", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10435960", "map_id": "none", "name": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10435952", "map_id": "none", "name": "Homologues of 3OHD110-F9(29-461)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10436711", "map_id": "none", "name": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10436703", "map_id": "none", "name": "Homologues of PROZ(24-400)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10435926", "map_id": "none", "name": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10435924", "map_id": "none", "name": "pro-protein C, uncarboxylated", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10435970", "map_id": "none", "name": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10435968", "map_id": "none", "name": "pro-factor X, uncarboxylated", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10436719", "map_id": "none", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10436715", "map_id": "Q9W0A0", "name": "drpr", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "species_10436717", "map_id": "Q9W0A0", "name": "drpr", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "false" }, { "id": "reaction_10435946", "map_id": "none", "name": "Furin cleaves pro-factor IX to factor IX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10435938", "map_id": "none", "name": "Homologues of 12xCbxE-3D-F9(47-461)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10435944", "map_id": "none", "name": "Homologues of factor IX propeptide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10435801", "map_id": "none", "name": "Furin cleaves pro-factor X to factor X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10435793", "map_id": "none", "name": "Homologues of factor X light chain propeptide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10435787", "map_id": "none", "name": "factor X", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10435895", "map_id": "none", "name": "Furin cleaves pro-protein C to protein C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10435893", "map_id": "none", "name": "Homologues of PROC(33-42)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10435887", "map_id": "none", "name": "protein C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10436677", "map_id": "none", "name": "Furin cleaves pro-protein Z to protein Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10436675", "map_id": "none", "name": "Homologues of PROZ(24-40)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10436669", "map_id": "none", "name": "Homologues of 13xCbxE-PROZ", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10435986", "map_id": "none", "name": "Furin cleaves pro-factor VII to factor VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_20699", "compartment_display": "Golgi membrane" }, { "id": "species_10435984", "map_id": "none", "name": "Homologues of factor VII propeptide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "species_10435978", "map_id": "none", "name": "Homologues of factor VII", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17963", "compartment_display": "Golgi lumen", "complex": "true" }, { "id": "reaction_10480016", "map_id": "none", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_6788753", "map_id": "CHEBI:86019", "name": "S-FARN-Cys", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_6788758", "map_id": "CHEBI:87167", "name": "S-FARN-CME", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10494803", "map_id": "none", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen" }, { "id": "species_10494300", "map_id": "none", "name": "FAM20C:FAM20C substrates", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "A4VCL2", "map_id": "A4VCL2", "name": "FAM20A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051145", "map_id": "FBgn0051145", "name": "FAM20A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VP10", "map_id": "Q9VP10", "name": "S1P", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VTZ5", "map_id": "Q9VTZ5", "name": "phospho-Tsf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036299", "map_id": "FBgn0036299", "name": "phospho-Tsf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLC3", "map_id": "Q9VLC3", "name": "phospho-Mco1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032116", "map_id": "FBgn0032116", "name": "phospho-Mco1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VX11", "map_id": "Q9VX11", "name": "phospho-Mco4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052557", "map_id": "FBgn0052557", "name": "phospho-Mco4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBK7", "map_id": "Q9VBK7", "name": "phospho-Mco3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039387", "map_id": "FBgn0039387", "name": "phospho-Mco3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVK3", "map_id": "Q9VVK3", "name": "phospho-Ccn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052183", "map_id": "FBgn0052183", "name": "phospho-Ccn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VUX3", "map_id": "Q9VUX3", "name": "phospho-Notum", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVK7", "map_id": "Q9VVK7", "name": "phospho-NUCB1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052190", "map_id": "FBgn0052190", "name": "phospho-NUCB1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V438", "map_id": "Q9V438", "name": "phospho-CaBP1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025678", "map_id": "FBgn0025678", "name": "phospho-CaBP1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VJD1", "map_id": "Q9VJD1", "name": "phospho-GCS2beta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032643", "map_id": "FBgn0032643", "name": "phospho-GCS2beta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VAY2", "map_id": "Q9VAY2", "name": "phospho-Gp93", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "X2JEB0", "map_id": "X2JEB0", "name": "phospho-dtn", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0262730", "map_id": "FBgn0262730", "name": "phospho-dtn", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W0H8", "map_id": "Q9W0H8", "name": "phospho-scf", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0025682", "map_id": "FBgn0025682", "name": "phospho-scf", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8IMZ9", "map_id": "Q8IMZ9", "name": "phospho-wfs1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039003", "map_id": "FBgn0039003", "name": "phospho-wfs1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPI6", "map_id": "Q9VPI6", "name": "phospho-galectin", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031213", "map_id": "FBgn0031213", "name": "phospho-galectin", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPI7", "map_id": "Q9VPI7", "name": "phospho-Dmel\\CG11374", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031214", "map_id": "FBgn0031214", "name": "phospho-Dmel\\CG11374", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_8931885", "map_id": "CHEBI:30616", "name": "ATP", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10494796", "map_id": "none", "name": "FAM20C:Phosphorylated FAM20C substrates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "species_8931884", "map_id": "CHEBI:456216", "name": "ADP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "false" }, { "id": "species_10494801", "map_id": "none", "name": "FAM20C:FAM20A", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_17957", "compartment_display": "endoplasmic reticulum lumen", "complex": "true" }, { "id": "reaction_10444863", "map_id": "none", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10444851", "map_id": "none", "name": "Noradrenalin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_20592", "compartment_display": "clathrin-coated endocytic vesicle", "complex": "true" }, { "id": "species_10444853", "map_id": "none", "name": "Docked Noradrenalin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10444858", "map_id": "none", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10444855", "map_id": "Q8IH57", "name": "Vmat", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10444371", "map_id": "none", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen" }, { "id": "species_10444368", "map_id": "Q8IH57", "name": "Vmat", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "false" }, { "id": "reaction_10496500", "map_id": "none", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_8982080", "map_id": "none", "name": "c-di-AMP, c-di-GMP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:49537", "map_id": "CHEBI:49537", "name": "CHEBI:49537", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:47037", "map_id": "CHEBI:47037", "name": "CHEBI:47037", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467519", "map_id": "Q9V3C0", "name": "abs", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0015331", "map_id": "FBgn0015331", "name": "abs", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496498", "map_id": "none", "name": "DDX41:c-di-AMP, c-di-GMP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V3C0", "map_id": "Q9V3C0", "name": "abs", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468991", "map_id": "none", "name": "Cdh1:APC/C complex binds EHMT1:EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468980", "map_id": "none", "name": "EHMT1:EHMT2:Cdh1:p-APC/C", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468989", "map_id": "none", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10468986", "map_id": "none", "name": "Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468969", "map_id": "none", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10469079", "map_id": "none", "name": "CEBPB homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469061", "map_id": "none", "name": "Homologues of p-T235, S321-CEBPB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10469063", "map_id": "none", "name": "p-T235,S321-CEBPB homodimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468966", "map_id": "none", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10469077", "map_id": "none", "name": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10469069", "map_id": "none", "name": "Homologues of CEBPB", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10469075", "map_id": "none", "name": "Homologues of p-T235-CEBPB", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10447725", "map_id": "none", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10446959", "map_id": "none", "name": "Ca permeable AMPA receptor ligand complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447723", "map_id": "none", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10446957", "map_id": "none", "name": "Ca permeable AMPA receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447721", "map_id": "none", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10446946", "map_id": "none", "name": "Ca impermeable AMPA receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10446951", "map_id": "none", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_350405", "map_id": "none", "name": "RHOGEF2 binds to RHO1:GDP complex at the plasma membrane", "reversible": "false", "notes": "At the plasma membrane, Rho guanyl-nucleotide exchange factor (RHOGEF2) associates with the inactive Rho GTPase complex (RHO1:GDP).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_350999", "map_id": "none", "name": "RHO1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_350951", "map_id": "O44113", "name": "RHOGEF2", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_351056", "map_id": "none", "name": "RHOGEF2:RHO1:GDP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "O44113", "map_id": "O44113", "name": "RHOGEF2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "RHOGEF2", "map_id": "RHOGEF2", "name": "RHOGEF2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_350453", "map_id": "none", "name": "RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane", "reversible": "false", "notes": "Rho GTPase activator (RHOGAPP190) associates with the activated Rho GTPase complex (RHO1:GTP) at the plasma membrane.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_350991", "map_id": "Q9VX32", "name": "RHOGAPP190", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_351000", "map_id": "none", "name": "RHOGAPP190:RHO1:GTP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_350359", "map_id": "none", "name": "RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane", "reversible": "false", "notes": "Inactive Rho GTPase complex (RHO1:GDP) dissociates from Rho GDP dissociation inhibitor (RHOGDI) and binds to the plasma membrane.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351058", "map_id": "none", "name": "RHOGDI:RHO1:GDP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_351008", "map_id": "Q9VW59", "name": "RHOGDI", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_350450", "map_id": "none", "name": "RHO1:GTP complex dissociates from RHOGEF2", "reversible": "false", "notes": "Rho guanyl-nucleotide exchange factor (RHOGEF2) dissociates from the activated Rho GTPase complex (RHO1:GTP).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_351086", "map_id": "none", "name": "RHOGEF2:RHO1:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_350477", "map_id": "none", "name": "RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex", "reversible": "false", "notes": "Rho guanyl-nucleotide exchange factor (RHOGEF2) catalyses GTP for GDP nucleotide exchange with the Rho GTPase complex (RHO1:GDP).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_350395", "map_id": "none", "name": "RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol", "reversible": "false", "notes": "Rho GDP dissociation inhibitor (RHOGDI) sequesters inactive Rho GTPase complex (RHO1:GDP) in the cytosol.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_350458", "map_id": "none", "name": "RHOGAPP190 activates GTP hydrolysis by RHO1:GTP", "reversible": "false", "notes": "RHOGAPP190 activates the GTPase activity of RHO1, leading to hydrolysis of its bound GTP.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351009", "map_id": "none", "name": "RHOGAPP190:RHO1:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_350410", "map_id": "none", "name": "RHO1:GDP complex dissociates from RHOGAPP190", "reversible": "false", "notes": "Rho GTPase activator (RHOGAPP190) dissociates from inactive Rho GTPase complex(RHO1:GDP).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10470223", "map_id": "none", "name": "p-S303,307-HSF1 binds YWHAE (14-3-3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10470219", "map_id": "P22813", "name": "phospho-Hsf", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10470221", "map_id": "none", "name": "p-S303,307-HSF1:YWHAE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10471487", "map_id": "none", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471418", "map_id": "none", "name": "HSP70s:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10471276", "map_id": "none", "name": "HSP70s:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10471470", "map_id": "none", "name": "HSP70 NEFs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "M9MSL3", "map_id": "M9MSL3", "name": "Hsc70Cb", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026418", "map_id": "FBgn0026418", "name": "Hsc70Cb", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JNS4", "map_id": "A8JNS4", "name": "stv", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0086708", "map_id": "FBgn0086708", "name": "stv", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q95RY2", "map_id": "Q95RY2", "name": "CG17014", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036505", "map_id": "FBgn0036505", "name": "CG17014", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471485", "map_id": "none", "name": "ST13 tetramer", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q86DS1", "map_id": "Q86DS1", "name": "HIP-R", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029676", "map_id": "FBgn0029676", "name": "HIP-R", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "C4NYP8", "map_id": "C4NYP8", "name": "HIP", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0260484", "map_id": "FBgn0260484", "name": "HIP", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10471450", "map_id": "none", "name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471278", "map_id": "none", "name": "Hikeshi:HSP70s:ATP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9W0C7", "map_id": "Q9W0C7", "name": "Hikeshi", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035243", "map_id": "FBgn0035243", "name": "Hikeshi", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10471354", "map_id": "none", "name": "Hikeshi:HSP70s:ATP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10470217", "map_id": "none", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468527", "map_id": "P22813", "name": "Hsf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10470214", "map_id": "P22813", "name": "phospho-Hsf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10471528", "map_id": "none", "name": "RPA1 binds HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471526", "map_id": "none", "name": "HSF1:RPA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471429", "map_id": "none", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471426", "map_id": "none", "name": "DNAJB1,B6,C2,C7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VP77", "map_id": "Q9VP77", "name": "Dmel\\CG10565", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037051", "map_id": "FBgn0037051", "name": "Dmel\\CG10565", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8DYF7", "map_id": "A8DYF7", "name": "mrj", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034091", "map_id": "FBgn0034091", "name": "mrj", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V3W1", "map_id": "Q9V3W1", "name": "Tpr2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032586", "map_id": "FBgn0032586", "name": "Tpr2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10468628", "map_id": "none", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468626", "map_id": "P22813", "name": "phospho-Hsf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10468532", "map_id": "none", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468530", "map_id": "P22813", "name": "phospho-Hsf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10471396", "map_id": "none", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10471376", "map_id": "none", "name": "HSP70s:ADP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10471352", "map_id": "Q9W0C7", "name": "Hikeshi", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10471393", "map_id": "none", "name": "DNAJB1,B6,C2,C7", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10471280", "map_id": "none", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10471200", "map_id": "Q9W0C7", "name": "Hikeshi", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10498679", "map_id": "none", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_10497384", "map_id": "none", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475840", "map_id": "none", "name": "Active FLT3:GRB2:SOS1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10454271", "map_id": "none", "name": "IL3 stimulation induces Vav binding to Tec kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10442646", "map_id": "P08630", "name": "Btk29A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10442471", "map_id": "Q9NHV9", "name": "Vav", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10454269", "map_id": "none", "name": "TEC:VAV1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10454509", "map_id": "none", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454503", "map_id": "none", "name": "p(Y700,731,774)-CBL:CRK", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10454507", "map_id": "none", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454505", "map_id": "none", "name": "p(Y700,731,774)-CBL:CRK:RAPGEF1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10454281", "map_id": "none", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10453140", "map_id": "none", "name": "p85-containing Class 1A PI3Ks", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10454279", "map_id": "none", "name": "FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10454501", "map_id": "none", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454499", "map_id": "none", "name": "p(Y700,731,774)-CBL:VAV1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10454497", "map_id": "none", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454434", "map_id": "none", "name": "FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10454495", "map_id": "none", "name": "FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10495825", "map_id": "none", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495805", "map_id": "none", "name": "2 x p-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10495823", "map_id": "none", "name": "2 x p-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495817", "map_id": "none", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495811", "map_id": "none", "name": "2 x p-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10495815", "map_id": "none", "name": "2xp-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10495819", "map_id": "none", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10495809", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10495807", "map_id": "none", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493643", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10450767", "map_id": "none", "name": "Caspase-3 cleaves pro-interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10450760", "map_id": "Q9VUE8", "name": "bbg", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0087007", "map_id": "FBgn0087007", "name": "bbg", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10450762", "map_id": "Q9VUE8", "name": "bbg", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10450764", "map_id": "Q9VUE8", "name": "bbg", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10496506", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10450776", "map_id": "Q9VBL3", "name": "Dmel\\CG5886", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0039379", "map_id": "FBgn0039379", "name": "Dmel\\CG5886", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10496502", "map_id": "Q24547", "name": "Syx1A", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10496504", "map_id": "none", "name": "TXLNA:STX3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VBL3", "map_id": "Q9VBL3", "name": "Dmel\\CG5886", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10450771", "map_id": "none", "name": "Interleukin-16 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10450769", "map_id": "Q9VUE8", "name": "bbg", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10450786", "map_id": "none", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10450778", "map_id": "none", "name": "TXLNA:STX1A", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10450784", "map_id": "none", "name": "STXA1:SNAP25,STXBP2, VAMP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10493651", "map_id": "none", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493647", "map_id": "none", "name": "p-STAT1:p-STAT4", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10493649", "map_id": "none", "name": "p-Y693-STAT4:p-Y701-STAT1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493665", "map_id": "none", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454425", "map_id": "Q24151", "name": "phospho-Stat92E", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10457722", "map_id": "none", "name": "p-Y701-STAT1: p-Y-705-STAT3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10493659", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10457730", "map_id": "none", "name": "p-Y701-STAT1:p-Y705-STAT3", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493640", "map_id": "none", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10493634", "map_id": "none", "name": "p-Y693-STAT4 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10493638", "map_id": "none", "name": "Y963-STAT4 dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10493661", "map_id": "none", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10475576", "map_id": "none", "name": "26Sproteasome degrades K48polyUb-NIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10475574", "map_id": "Q8MSQ4", "name": "Mekk1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_451846", "map_id": "none", "name": "LFT binds to FT and DS", "reversible": "false", "notes": "The small protein Lowfat (LFT) binds to the cytoplasmic domains of the cadherin domain containing transmembrane proteins Fat (FT) and Dachsous (DS). The function of LFT is currently unknown but it does appear to increase FT and DS protein levels.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_451871", "map_id": "Q9VKY1", "name": "LFT", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_451879", "map_id": "none", "name": "LFT:DS:Phospho FT:LFT:DCO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9VKY1", "map_id": "Q9VKY1", "name": "LFT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "LFT", "map_id": "LFT", "name": "LFT", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_451858", "map_id": "none", "name": "YKI binds to HPO homodimer", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Hippo (HPO) homodimer PPXY sequence motif, of which HPO has one per monomer unit. YKI remains in the cytosol where it is unable to activate its target genes.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_451843", "map_id": "none", "name": "HPO dimer:YKI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_451826", "map_id": "none", "name": "YKI binds to EX", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Expanded (EX) PPXY sequence motif, of which EX has three. YKI remains in the cytosol where it is unable to activate its target genes.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_451874", "map_id": "Q07436", "name": "EX", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_451822", "map_id": "none", "name": "EX:YKI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q07436", "map_id": "Q07436", "name": "EX", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "EX", "map_id": "EX", "name": "EX", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_451811", "map_id": "none", "name": "YKI binds to WTS", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Warts (WTS) PPXY sequence motif, of which WTS has five. YKI remains in the cytosol where it is unable to activate its target genes.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_451862", "map_id": "none", "name": "WTS:YKI", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_390120", "map_id": "none", "name": "Phosphorylated HPO dimer phosphorylates TH", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase phosphorylates Thread (TH) aka drosophila inhibitor of apoptosis protein 1 (Diap1) at unknown residues. This affects TH's stability.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390182", "map_id": "Q24306", "name": "TH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_390103", "map_id": "Q24306", "name": "Phospho TH", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_390059", "map_id": "none", "name": "HPO dimer binds to RASSF", "reversible": "false", "notes": "Ras association family member (RASSF) associates with inactive Hippo (HPO) kinase homodimer through their shared SARAH (Salvador/Rassf/Hippo) domains. It should be noted that Hippo (HPO) kinase domain also associates with scaffolding protein Salvador (SAV) through SARAH domains. However, RASSF fails to bind to SAV. HPO associated with RASSF shows barely detectable levels of phosphorylation. In this complex, HPO homodimer remains unphosphorylated and inactive. Thus, RASSF restricts HPO activity by competing with SAV for binding to HPO homodimer.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_390054", "map_id": "Q9VCQ7", "name": "RASSF", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_390177", "map_id": "none", "name": "HPO dimer:RASSF", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VCQ7", "map_id": "Q9VCQ7", "name": "RASSF", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "RASSF", "map_id": "RASSF", "name": "RASSF", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10458089", "map_id": "none", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458077", "map_id": "Q24167", "name": "sima", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10458083", "map_id": "Q24167", "name": "sima", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10458148", "map_id": "none", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458124", "map_id": "none", "name": "HIF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10458130", "map_id": "none", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10458128", "map_id": "none", "name": "HIF:CBP:p300", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10443099", "map_id": "none", "name": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10443096", "map_id": "none", "name": "SOS-1 bound to Tie2:Grb2", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10467110", "map_id": "none", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10467106", "map_id": "M9PIG4", "name": "Glg1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0264561", "map_id": "FBgn0264561", "name": "Glg1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467101", "map_id": "none", "name": "Homologues of SELE", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10467108", "map_id": "none", "name": "2xSELE ligands:SELE", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "M9PIG4", "map_id": "M9PIG4", "name": "Glg1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10464490", "map_id": "none", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10464487", "map_id": "none", "name": "PLD", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10464470", "map_id": "none", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10464465", "map_id": "Q8IGV3", "name": "WUN-like", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10464499", "map_id": "none", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_428981", "map_id": "CHEBI:17504", "name": "LPC", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "false" }, { "id": "reaction_10467643", "map_id": "none", "name": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467633", "map_id": "none", "name": "CCND1:CDK4:PRMT5:WDR77", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9U6Y9", "map_id": "Q9U6Y9", "name": "phospho-csul", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015925", "map_id": "FBgn0015925", "name": "phospho-csul", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VIP8", "map_id": "Q9VIP8", "name": "vls", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0003978", "map_id": "FBgn0003978", "name": "vls", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467640", "map_id": "none", "name": "CCND1:CDK4:PRMT5:pT5-WDR77", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10467720", "map_id": "none", "name": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467638", "map_id": "none", "name": "PRMT5:pT5-WDR77", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10467718", "map_id": "none", "name": "SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10467650", "map_id": "none", "name": "PRMT5 binds WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467624", "map_id": "Q9VIP8", "name": "vls", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10467629", "map_id": "Q9U6Y9", "name": "csul", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10467631", "map_id": "none", "name": "PRMT5:WDR77", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10467648", "map_id": "Q9U6Y9", "name": "phospho-csul", "type": "inhibitor", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10467501", "map_id": "none", "name": "MAPKs phosphorylate ETS1 and ETS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10467496", "map_id": "P51023", "name": "pnt", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0003118", "map_id": "FBgn0003118", "name": "pnt", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467499", "map_id": "P51023", "name": "phospho-pnt", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10476303", "map_id": "none", "name": "MRN complex binds shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_3785706", "map_id": "none", "name": "Shortened telomere", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "species_10476301", "map_id": "none", "name": "Shortened telomere:MRN", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10481055", "map_id": "none", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10481052", "map_id": "none", "name": "Shortened telomere:MRN:ATM dimer:KAT5", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10476309", "map_id": "none", "name": "Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10454382", "map_id": "none", "name": "Release of GABA at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10454363", "map_id": "none", "name": "Docked GABA loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "A1Z9M6", "map_id": "A1Z9M6", "name": "VGAT", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P20228", "map_id": "P20228", "name": "Gad1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004516", "map_id": "FBgn0004516", "name": "Gad1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10454369", "map_id": "P11147", "name": "Hsc70-4", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10442983", "map_id": "M9PE32", "name": "Fife", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_352003", "map_id": "CHEBI:59888", "name": "GABA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10454379", "map_id": "none", "name": "PXLP-GAD dimers", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10454365", "map_id": "A1Z9M6", "name": "VGAT", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10454367", "map_id": "Q03751", "name": "Csp", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10455094", "map_id": "none", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_917758", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle" }, { "id": "species_10454361", "map_id": "none", "name": "GABA Loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "reaction_10454328", "map_id": "none", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10454325", "map_id": "none", "name": "PXLP-K405-GAD1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "reaction_10454340", "map_id": "none", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane" }, { "id": "species_10454337", "map_id": "none", "name": "PXLP-GAD dimers", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "true" }, { "id": "reaction_10454385", "map_id": "none", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_428571", "map_id": "CHEBI:59888", "name": "GABA", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_917775", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen", "complex": "false" }, { "id": "species_10454349", "map_id": "A1Z9M6", "name": "VGAT", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_917757", "compartment_display": "clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane", "complex": "false" }, { "id": "reaction_10465871", "map_id": "none", "name": "AWAT2 transfers PALM to 11cROL forming 11cRPALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431863", "map_id": "none", "name": "RLBP1:11cROL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10465860", "map_id": "none", "name": "RLBP1:11cRPALM", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "CHEBI:16254", "map_id": "CHEBI:16254", "name": "CHEBI:16254", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465892", "map_id": "none", "name": "RLBP1 binds atROL to form RLBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10431861", "map_id": "none", "name": "Homologues of RLBP1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_2473617", "map_id": "CHEBI:17336", "name": "atROL", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465890", "map_id": "none", "name": "RLBP1:atROL", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10465888", "map_id": "none", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2473607", "map_id": "CHEBI:17336", "name": "atROL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10465885", "map_id": "none", "name": "Homologues of DHRS3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_74000", "compartment_display": "photoreceptor outer segment membrane", "complex": "true" }, { "id": "reaction_10484702", "map_id": "none", "name": "PGLYRP3,4 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6789198", "map_id": "CHEBI:55424", "name": "GlcNac-(1-->4)MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10484698", "map_id": "none", "name": "PGLYRP3,4 dimers", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10484700", "map_id": "none", "name": "PGLYRP3,4 dimer:peptidoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10485860", "map_id": "none", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10485854", "map_id": "none", "name": "REG3A(38-175):anionic phospholipids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "CHEBI:62643", "map_id": "CHEBI:62643", "name": "CHEBI:62643", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10485858", "map_id": "none", "name": "REG3A hexamer:anionic phospholipid", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_166005", "map_id": "CHEBI:16412", "name": "LPS", "type": "reactant", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10489510", "map_id": "none", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10482357", "map_id": "none", "name": "Homologues of LYZ", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10489508", "map_id": "none", "name": "LYZ:PGN", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10489513", "map_id": "none", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6788991", "map_id": "none", "name": "MurNAc:Peptide", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "true" }, { "id": "CHEBI:21615", "map_id": "CHEBI:21615", "name": "CHEBI:21615", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_6788982", "map_id": "CHEBI:28009", "name": "betaGlcNAc", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_1222574", "compartment_display": "cell wall", "complex": "false" }, { "id": "reaction_10486923", "map_id": "none", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6803081", "map_id": "CHEBI:16412", "name": "LPS", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10486917", "map_id": "Q9VB21", "name": "Dmel\\CG5639", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10486921", "map_id": "none", "name": "PI3:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10484723", "map_id": "none", "name": "PGLYRP2 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10484716", "map_id": "none", "name": "PGLYRP2 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10484718", "map_id": "none", "name": "PGLYRP2:peptidoglycan", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10484721", "map_id": "none", "name": "PGLYRP2 hydrolyzes bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_6799970", "map_id": "none", "name": "(GlcNAc+MurNac)n", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_6799975", "map_id": "CHEBI:61626", "name": "L-Ala-gamma-D-Glu-L-Lys-D-Ala", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "reaction_10489521", "map_id": "none", "name": "PLA2G2A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_8931784", "map_id": "none", "name": "Anionic phospholipids:microbial cell surface", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10460239", "map_id": "none", "name": "PLA2G2A:Ca2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10489519", "map_id": "none", "name": "PLA2G2A:phospholipids", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10480075", "map_id": "none", "name": "PGLYRP1 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_10480071", "map_id": "none", "name": "PGLYRP1 dimer", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "species_10480073", "map_id": "none", "name": "PGLYRP1dimer:peptidoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "reaction_10485878", "map_id": "none", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10485852", "map_id": "none", "name": "Homologues of REG3A(38-175)", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10485882", "map_id": "none", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10485880", "map_id": "none", "name": "REG3A(38-175), REG3G(38-175):peptidoglycan", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10457859", "map_id": "none", "name": "Lactoferrin scavenges iron ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen" }, { "id": "species_2101051", "map_id": "CHEBI:41609", "name": "CO3(2-)", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10457855", "map_id": "none", "name": "Homologues of LTF", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "species_10457857", "map_id": "none", "name": "LTF:2xFe3+:2xCO3(2-)", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_1222282", "compartment_display": "phagocytic vesicle lumen", "complex": "true" }, { "id": "reaction_10467566", "map_id": "none", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_874088", "map_id": "CHEBI:16991", "name": "Double-stranded DNA", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10467562", "map_id": "Q9XYZ4", "name": "mre11", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467564", "map_id": "none", "name": "MRE11:dsDNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10467514", "map_id": "none", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10467512", "map_id": "P18824", "name": "phospho-arm", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10467510", "map_id": "P18824", "name": "phospho-arm", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10458430", "map_id": "none", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10458426", "map_id": "none", "name": "Homologues of TXNIP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VGU4", "map_id": "Q9VGU4", "name": "Leash", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037856", "map_id": "FBgn0037856", "name": "Leash", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A8JQV1", "map_id": "A8JQV1", "name": "Dmel\\CG18748", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042105", "map_id": "FBgn0042105", "name": "Dmel\\CG18748", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7L1", "map_id": "Q9I7L1", "name": "Dmel\\CG18747", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042104", "map_id": "FBgn0042104", "name": "Dmel\\CG18747", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VI53", "map_id": "Q9VI53", "name": "Dmel\\CG1105", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037465", "map_id": "FBgn0037465", "name": "Dmel\\CG1105", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7L0", "map_id": "Q9I7L0", "name": "Dmel\\CG18745", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042102", "map_id": "FBgn0042102", "name": "Dmel\\CG18745", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VI00", "map_id": "Q9VI00", "name": "Dmel\\CG2641", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037518", "map_id": "FBgn0037518", "name": "Dmel\\CG2641", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7K8", "map_id": "Q9I7K8", "name": "Dmel\\CG18746", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042103", "map_id": "FBgn0042103", "name": "Dmel\\CG18746", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHZ9", "map_id": "Q9VHZ9", "name": "Dmel\\CG3014", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037519", "map_id": "FBgn0037519", "name": "Dmel\\CG3014", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9I7K7", "map_id": "Q9I7K7", "name": "Dmel\\CG18744", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0042101", "map_id": "FBgn0042101", "name": "Dmel\\CG18744", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VHZ8", "map_id": "Q9VHZ8", "name": "Dmel\\CG18268", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037520", "map_id": "FBgn0037520", "name": "Dmel\\CG18268", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q8SYU5", "map_id": "Q8SYU5", "name": "Dmel\\CG10086", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037517", "map_id": "FBgn0037517", "name": "Dmel\\CG10086", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VGU7", "map_id": "Q9VGU7", "name": "Dmel\\CG14696", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0037853", "map_id": "FBgn0037853", "name": "Dmel\\CG14696", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q0E8K8", "map_id": "Q0E8K8", "name": "Vdup1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0035103", "map_id": "FBgn0035103", "name": "Vdup1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10458428", "map_id": "none", "name": "Thioredoxin:TXNIP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10458432", "map_id": "none", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10464323", "map_id": "none", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10437523", "map_id": "none", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_168948", "map_id": "none", "name": "Ligand recognized by TLR10", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "false" }, { "id": "species_10437517", "map_id": "Q9VPH1", "name": "Toll-9", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10437521", "map_id": "none", "name": "TLR10 homodimer bound to ligand", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10485986", "map_id": "none", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10485978", "map_id": "none", "name": "Homologues of HC23,45-HMGB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10485984", "map_id": "none", "name": "HC23,45-HMGB1:LPS", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10486230", "map_id": "none", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10443916", "map_id": "none", "name": "Homologues of HMGB1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10485982", "map_id": "none", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_181015", "map_id": "CHEBI:28640", "name": "Lipoteichoic acid", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none", "complex": "false" }, { "id": "species_10485980", "map_id": "none", "name": "HC23,45-HMGB1:LTA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_10434118", "map_id": "none", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "reaction_390141", "map_id": "none", "name": "D inhibits WTS", "reversible": "false", "notes": "In the absence of the transmembrane cadherin Fat (FT), the unconventional myosin Dachs (D) accumulates at the plasma membrane where it has access to and inhibits Warts (WTS) kinase.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10495859", "map_id": "none", "name": "ATRX binds DAXX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10495855", "map_id": "A1Z8R2", "name": "ADD1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0026573", "map_id": "FBgn0026573", "name": "ADD1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10467725", "map_id": "Q9VMD0", "name": "Daxx", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "FBgn0031820", "map_id": "FBgn0031820", "name": "Daxx", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10495857", "map_id": "none", "name": "ATRX:DAXX", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VMD0", "map_id": "Q9VMD0", "name": "Daxx", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A1Z8R2", "map_id": "A1Z8R2", "name": "ADD1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10435134", "map_id": "none", "name": "factor VII -> factor VIIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10435117", "map_id": "none", "name": "10xCbxE-F7(61-466):Ca2+", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10435131", "map_id": "none", "name": "factor VIIa", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "species_10435079", "map_id": "none", "name": "factor Xa", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_984", "compartment_display": "extracellular region", "complex": "true" }, { "id": "reaction_350400", "map_id": "none", "name": "PK binds to DSH", "reversible": "false", "notes": "The PET/LIM domain of Prickle (PK) interacts with DEP domain and C-terminus of Dishevelled (DSH). The DEP domain is required by DSH for membrane localisation. Binding of Diego (DGO) and PK to DSH is mutually exclusive. PK binding to DSH prevents FZ PCP signalling.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351069", "map_id": "none", "name": "PK:DSH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_350403", "map_id": "none", "name": "DGO binds to PK", "reversible": "false", "notes": "In the cytosol, Diego (DGO) can bind to Prickle (PK). This may result in there being less DGO to bind to and stabilise the Frizzled (FZ):Dishevelled (DSH) complex.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351093", "map_id": "none", "name": "PK:DGO", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10445880", "map_id": "none", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10445872", "map_id": "none", "name": "Serotonin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "true" }, { "id": "species_10445808", "map_id": "none", "name": "Synapsin", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "false" }, { "id": "species_10445874", "map_id": "none", "name": "Docked serotonin loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10445877", "map_id": "none", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "reaction_10445844", "map_id": "none", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen" }, { "id": "species_380585", "map_id": "CHEBI:28790", "name": "5HT", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_374932", "compartment_display": "clathrin-sculpted monoamine transport vesicle lumen", "complex": "false" }, { "id": "reaction_10445870", "map_id": "none", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10445810", "map_id": "none", "name": "Docked dopamine loaded synaptic vesicle", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10471622", "map_id": "none", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445833", "map_id": "Q8IMT8", "name": "veli", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "FBgn0039269", "map_id": "FBgn0039269", "name": "veli", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445823", "map_id": "none", "name": "Homologues of APBA1", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "X2JE74", "map_id": "X2JE74", "name": "X11L", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0026313", "map_id": "FBgn0026313", "name": "X11L", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2S5", "map_id": "Q9W2S5", "name": "X11Lbeta", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0052677", "map_id": "FBgn0052677", "name": "X11Lbeta", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10445839", "map_id": "none", "name": "LIN7:CASK:APBA1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q8IMT8", "map_id": "Q8IMT8", "name": "veli", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10445841", "map_id": "none", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10445797", "map_id": "none", "name": "Dopamine loaded synaptic vesicle", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_374940", "compartment_display": "clathrin-sculpted monoamine transport vesicle membrane", "complex": "true" }, { "id": "reaction_10442917", "map_id": "none", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10442914", "map_id": "none", "name": "Voltage Gated Ca2+ Channel", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453885", "map_id": "none", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10453878", "map_id": "none", "name": "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W288", "map_id": "Q9W288", "name": "NtR", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029147", "map_id": "FBgn0029147", "name": "NtR", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VPQ8", "map_id": "Q9VPQ8", "name": "nAChRbeta3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031261", "map_id": "FBgn0031261", "name": "nAChRbeta3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P25162", "map_id": "P25162", "name": "nAChRbeta2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004118", "map_id": "FBgn0004118", "name": "nAChRbeta2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P17644", "map_id": "P17644", "name": "nAChRalpha2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000039", "map_id": "FBgn0000039", "name": "nAChRalpha2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P04755", "map_id": "P04755", "name": "nAChRbeta1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000038", "map_id": "FBgn0000038", "name": "nAChRbeta1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A0S0WNY8", "map_id": "A0A0S0WNY8", "name": "nAChRalpha4", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266347", "map_id": "FBgn0266347", "name": "nAChRalpha4", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3G6", "map_id": "Q9W3G6", "name": "nAChRalpha3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0015519", "map_id": "FBgn0015519", "name": "nAChRalpha3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "A0A499GGQ3", "map_id": "A0A499GGQ3", "name": "nAChRalpha5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0028875", "map_id": "FBgn0028875", "name": "nAChRalpha5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10453880", "map_id": "none", "name": "O-acteylcholine bound to calcium permeable postsynaptic nicotinic acetylcholine receptors", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453883", "map_id": "none", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10453827", "map_id": "none", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_984", "compartment_display": "extracellular region" }, { "id": "species_10453820", "map_id": "none", "name": "Highly sodium permeable nicotinic acetylcholine receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10453822", "map_id": "none", "name": "O-Acetylcholine bound to Acetylcholine receptor", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10453825", "map_id": "none", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "reaction_10455728", "map_id": "none", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10455725", "map_id": "none", "name": "GLRA:GLRB:Gly", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W4G1", "map_id": "Q9W4G1", "name": "CT21430", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029733", "map_id": "FBgn0029733", "name": "CT21430", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVH4", "map_id": "Q9VVH4", "name": "SecCl", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036727", "map_id": "FBgn0036727", "name": "SecCl", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9V9Y4", "map_id": "Q9V9Y4", "name": "pHCl-2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039840", "map_id": "FBgn0039840", "name": "pHCl-2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q94900", "map_id": "Q94900", "name": "GluClalpha", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0024963", "map_id": "FBgn0024963", "name": "GluClalpha", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "M9PI70", "map_id": "M9PI70", "name": "pHCl-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0264908", "map_id": "FBgn0264908", "name": "pHCl-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_350444", "map_id": "none", "name": "ROK phosphorylates SQH", "reversible": "false", "notes": "Myosin regulatory light chain (MRLC) orthologue Spaghetti Squash (SQH) is phosphorylated at Thr20 and Ser21 by Rho-kinase (ROK). Zipper (ZIP) the myosin heavy chain orthologue would be expected to have its conformation modified and catalytic ativity elevated upon SQH phosphorylation. This leads to cytoskeletal organisation and correct pre-hair orientation.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351068", "map_id": "none", "name": "Non-muscle Myosin II", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_351002", "map_id": "none", "name": "Phospho non-muscle Myosin II", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_350362", "map_id": "none", "name": "ROK phosphorylates MBS", "reversible": "false", "notes": "Myosin binding subunit (MBS) of Myosin phosphatase is phosphorylated at Thr594 by activated Rho-kinase (ROK). Myosin phosphatase is subsequently deactivated.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351071", "map_id": "none", "name": "Myosin phosphatase", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8IQN4", "map_id": "Q8IQN4", "name": "Phospho MBS", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Phospho MBS", "map_id": "Phospho MBS", "name": "Phospho MBS", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_351077", "map_id": "none", "name": "Phospho Myosin phosphatase", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10455221", "map_id": "none", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455216", "map_id": "none", "name": "SMG1:UPF1:EJC:Translated mRNP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "O46080", "map_id": "O46080", "name": "SMG9", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0023520", "map_id": "FBgn0023520", "name": "SMG9", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VKQ6", "map_id": "Q9VKQ6", "name": "SMG8", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032296", "map_id": "FBgn0032296", "name": "SMG8", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VYS3", "map_id": "Q9VYS3", "name": "phospho-Upf1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0030354", "map_id": "FBgn0030354", "name": "phospho-Upf1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W3L1", "map_id": "Q9W3L1", "name": "Upf2", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0029992", "map_id": "FBgn0029992", "name": "Upf2", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10455218", "map_id": "none", "name": "SMG1:Phosphorylated UPF1:EJC:Translated mRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10455200", "map_id": "none", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455197", "map_id": "none", "name": "Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9V414", "map_id": "Q9V414", "name": "Smg5", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0019890", "map_id": "FBgn0019890", "name": "Smg5", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VBZ6", "map_id": "Q9VBZ6", "name": "Smg6", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039260", "map_id": "FBgn0039260", "name": "Smg6", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10455182", "map_id": "none", "name": "mRNA Cleaved by SMG6", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10455156", "map_id": "none", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10455152", "map_id": "none", "name": "Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10455132", "map_id": "Q9VYS3", "name": "Upf1", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10455154", "map_id": "none", "name": "UPF1:eRF3 Complex on Translated mRNA", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10429278", "map_id": "none", "name": "Internal Methylation of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10429258", "map_id": "none", "name": "capped, methylated pre-mRNA:CBC Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10429275", "map_id": "none", "name": "mRNA (N6-adenosine)-methyltransferase", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q9VCE6", "map_id": "Q9VCE6", "name": "Mettl3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0039139", "map_id": "FBgn0039139", "name": "Mettl3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9Y091", "map_id": "Q9Y091", "name": "fl(2)d", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0000662", "map_id": "FBgn0000662", "name": "fl(2)d", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VLP7", "map_id": "Q9VLP7", "name": "Mettl14", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0032016", "map_id": "FBgn0032016", "name": "Mettl14", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432074", "map_id": "none", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432068", "map_id": "none", "name": "ATAC C Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "Q8IPW7", "map_id": "Q8IPW7", "name": "Dmel\\CG31922", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0051922", "map_id": "FBgn0051922", "name": "Dmel\\CG31922", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VR26", "map_id": "Q9VR26", "name": "Dmel\\CG3294", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0031628", "map_id": "FBgn0031628", "name": "Dmel\\CG3294", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10432072", "map_id": "none", "name": "Formation of AT-AC B Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432064", "map_id": "none", "name": "U4 ATAC:U5:U6 ATAC Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10432054", "map_id": "none", "name": "ATAC A Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10432066", "map_id": "none", "name": "ATAC B Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10432070", "map_id": "none", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10432058", "map_id": "none", "name": "U4 ATAC snRNP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10449034", "map_id": "none", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448979", "map_id": "none", "name": "Lsm1-7 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VEN9", "map_id": "Q9VEN9", "name": "Patr-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0266053", "map_id": "FBgn0266053", "name": "Patr-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9W2K2", "map_id": "Q9W2K2", "name": "LSm1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0261067", "map_id": "FBgn0261067", "name": "LSm1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10448981", "map_id": "none", "name": "Deadenylated mRNA:Lsm1-7 Complex", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10449015", "map_id": "none", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10448983", "map_id": "none", "name": "Decapped mRNA:LSM1-7 Complex", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_430004", "map_id": "CHEBI:20794", "name": "7-MeGDP", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449012", "map_id": "none", "name": "DCP1-DCP2 Decapping Complex", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q9VKK1", "map_id": "Q9VKK1", "name": "Ge-1", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0283682", "map_id": "FBgn0283682", "name": "Ge-1", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "Q9VVI2", "map_id": "Q9VVI2", "name": "Edc3", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0036735", "map_id": "FBgn0036735", "name": "Edc3", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P23128", "map_id": "P23128", "name": "me31B", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0004419", "map_id": "FBgn0004419", "name": "me31B", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10470317", "map_id": "none", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470281", "map_id": "none", "name": "p-S326-HSF1 trimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10470314", "map_id": "none", "name": "mTORC1 dimer", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10470283", "map_id": "none", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470233", "map_id": "none", "name": "HSF1 trimer:target gene", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10470271", "map_id": "none", "name": "Heat shock inducible proteins", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "P02517", "map_id": "P02517", "name": "Hsp26", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001225", "map_id": "FBgn0001225", "name": "Hsp26", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P22979", "map_id": "P22979", "name": "Hsp67Bc", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001229", "map_id": "FBgn0001229", "name": "Hsp67Bc", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02516", "map_id": "P02516", "name": "Hsp23", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001224", "map_id": "FBgn0001224", "name": "Hsp23", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P05812", "map_id": "P05812", "name": "Hsp67Ba", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001227", "map_id": "FBgn0001227", "name": "Hsp67Ba", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02515", "map_id": "P02515", "name": "Hsp22", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001223", "map_id": "FBgn0001223", "name": "Hsp22", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "P02518", "map_id": "P02518", "name": "Hsp27", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0001226", "map_id": "FBgn0001226", "name": "Hsp27", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10470276", "map_id": "none", "name": "p-S230-HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10470298", "map_id": "none", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470295", "map_id": "none", "name": "CaMKII", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "reaction_10468622", "map_id": "none", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468616", "map_id": "none", "name": "HSF1 trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10470302", "map_id": "none", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470300", "map_id": "P22813", "name": "Hsf", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10468653", "map_id": "none", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10470329", "map_id": "none", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_7660", "compartment_display": "nucleoplasm" }, { "id": "species_10470327", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10470325", "map_id": "none", "name": "HSP90:HSP90", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "true" }, { "id": "species_10470319", "map_id": "Q9VH95", "name": "PTGES3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_7660", "compartment_display": "nucleoplasm", "complex": "false" }, { "id": "reaction_10468645", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10468643", "map_id": "none", "name": "HSF1:HSP90:PTGES3", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10443622", "map_id": "Q9VH95", "name": "PTGES3", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10471524", "map_id": "none", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_5324631", "map_id": "none", "name": "Ub-protein aggregates", "type": "reactant", "sub_type": "", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10471519", "map_id": "none", "name": "HSF1:HSP90:HDAC6:VCP:PTGES3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10471521", "map_id": "none", "name": "HDAC6:VCP:protein aggregates", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_350441", "map_id": "none", "name": "FLW:MYPT-75D complex dephosphorylates SQH", "reversible": "false", "notes": "Flap wing (FLW) complexed with MYPT-75D dephosphorylates Spaghetti Squash (SQH).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_351064", "map_id": "P40423", "name": "Phospho SQH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_351041", "map_id": "P40423", "name": "SQH", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_351025", "map_id": "none", "name": "FLW:MYPT-75D", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "Q8SY34", "map_id": "Q8SY34", "name": "MYPT-75D", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "MYPT-75D", "map_id": "MYPT-75D", "name": "MYPT-75D", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_350475", "map_id": "none", "name": "FLW:MBS complex dephosphorylates SQH", "reversible": "false", "notes": "Flap wing (FLW) complexed with Myosin binding subunit (MBS) dephosphorylates Spaghetti Squash (SQH).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_350944", "map_id": "none", "name": "FLW:MBS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_350443", "map_id": "none", "name": "PP1-87B:MBS complex dephosphorylates SQH", "reversible": "false", "notes": "PP1-87B complexed with Myosin binding subunit (MBS) dephosphorylates Spaghetti Squash (SQH).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_350963", "map_id": "none", "name": "PP1-87B:MBS", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_450741", "map_id": "none", "name": "VANG, IN, FY, and FRTZ colocalise at the plasma membrane", "reversible": "false", "notes": "In the wing, Van Gogh (VANG) aka Strabismus (Stbm), Inturned (IN), Fuzzy (FY), and Fritz (FRTZ) all colocalise to the proximal side of the plasma membrane.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_450782", "map_id": "Q9VQ36", "name": "FRTZ", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_450722", "map_id": "O16868", "name": "FY", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_450756", "map_id": "Q9VPH0", "name": "IN", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_450770", "map_id": "none", "name": "MWH binds to RHO1:GTP and is activated", "reversible": "false", "notes": "In the wing, autoinhibited multiple wing hairs (MWH) protein via its GTPase binding domain (GBD) binds to activated RHO1:GTP at the proximal side of the plasma membrane. This relieves the inhibition in MWH and it is now activated. The previously blocked dimerisation domain (DD) is now exposed and able to bind to other formins in a dominant negative manner. The sequestered formins are now unable to promote actin polymerisation around the proximal edge of the cell. It is postulated that the MWH:formin complexes which form in proximity to the developing hair at the distal edge inhibit formation of secondary hairs. There is evidence in the literature that MWH is also phosphorylated by an unknown kinase but definitive proof that this is important for its activity is currently undetermined (Strutt and Warrington, 2008).", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_450759", "map_id": "Q9W0J2", "name": "MWH", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_450755", "map_id": "none", "name": "RHO1:GTP:MWH", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9W0J2", "map_id": "Q9W0J2", "name": "MWH", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "MWH", "map_id": "MWH", "name": "MWH", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_450802", "map_id": "none", "name": "FZ and VANG bind to STAN homodimer", "reversible": "false", "notes": "The seven-pass transmembrane protein Frizzled (FZ) and the four-pass transmembrane protein Van Gogh (VANG) aka Strabismus (Stbm) bind to opposite ends of the seven-pass transmembrane atypical cadherin Starry Night (STAN) aka Flamingo homodimer. In the case of VANG, this interaction is to the C-terminal domain of STAN. Additionally, there's a possibility of a direct interaction between FZ and VANG.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_205850", "map_id": "P18537", "name": "FZ", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_351026", "map_id": "none", "name": "STAN dimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_351126", "map_id": "O45030", "name": "VANG", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_350467", "map_id": "none", "name": "GUG binds to FT", "reversible": "false", "notes": "The transcriptional repressor Grunge (GUG) aka Atro binds to the intracellular domain of Fat (FT) reinforcing the corresponding strong genetic interaction evidence. GUG like FT is specifically required in the R3 photoreceptor.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_350975", "map_id": "Q9NHX6", "name": "GUG", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_350926", "map_id": "none", "name": "DS:FT:GUG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9NHX6", "map_id": "Q9NHX6", "name": "GUG", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "GUG", "map_id": "GUG", "name": "GUG", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_350377", "map_id": "none", "name": "Extracellular domains of STAN bind to each other in adjacent cells", "reversible": "false", "notes": "The seven-pass transmembrane atypical cadherin Starry Night (STAN) aka Flamingo is known to mediate homophilic protein-protein interaction.", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_350928", "map_id": "Q9V5N8", "name": "STAN", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10441901", "map_id": "none", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10441898", "map_id": "none", "name": "Active PKC theta bound to DAG", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10441919", "map_id": "none", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441912", "map_id": "Q9VXH3", "name": "phospho-sl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10441917", "map_id": "none", "name": "Activated PLC gamma1 bound to PIP2", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10441932", "map_id": "none", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10441929", "map_id": "Q9VXH3", "name": "phospho-sl", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10447468", "map_id": "none", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447466", "map_id": "none", "name": "F2R:ARRB1:MAPKs:SRC-1", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447489", "map_id": "none", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447487", "map_id": "none", "name": "F2R:ARRB2:MAPKs:SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10447473", "map_id": "none", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10447470", "map_id": "none", "name": "F2R:ARRB1:active MAPKs:active SRC-1", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449789", "map_id": "none", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449781", "map_id": "none", "name": "VAV3 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10449783", "map_id": "none", "name": "VAV3 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10449786", "map_id": "Q9NHV9", "name": "phospho-Vav", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "reaction_10435017", "map_id": "none", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10435014", "map_id": "Q9VXH3", "name": "phospho-sl", "type": "product", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10449704", "map_id": "none", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10448868", "map_id": "none", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10448866", "map_id": "Q9VXH3", "name": "sl", "type": "reactant", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "reaction_10449763", "map_id": "none", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449751", "map_id": "none", "name": "VAV1 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10449753", "map_id": "none", "name": "VAV1 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10449756", "map_id": "Q9NHV9", "name": "phospho-Vav", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10449761", "map_id": "none", "name": "PIP3:VAV1,2,3", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10449759", "map_id": "none", "name": "VAV family:PIP2", "type": "inhibitor", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "reaction_10449777", "map_id": "none", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_10449769", "map_id": "none", "name": "VAV2 Rho/Rac effectors:GDP", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_10449771", "map_id": "none", "name": "VAV2 Rho/Rac effectors:GTP", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "reaction_10446140", "map_id": "none", "name": "Olfactory Receptor - G Protein olfactory trimer complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_876", "compartment_display": "plasma membrane" }, { "id": "species_10446099", "map_id": "none", "name": "Olfactory receptors", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446067", "map_id": "none", "name": "GNAL:GNB1:GNG13", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "Q9NFZ3", "map_id": "Q9NFZ3", "name": "Ggamma30A", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0267252", "map_id": "FBgn0267252", "name": "Ggamma30A", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_10446101", "map_id": "none", "name": "Olfactory receptor:G protein trimer", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "true" }, { "id": "species_10446138", "map_id": "none", "name": "REEPs", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "Q9W1J5", "map_id": "Q9W1J5", "name": "Dmel\\CG5539", "type": "complex_component", "sub_type": "protein_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "FBgn0034907", "map_id": "FBgn0034907", "name": "Dmel\\CG5539", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10446069", "map_id": "none", "name": "G Protein trimer formation (olfactory)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "species_2864099", "map_id": "none", "name": "atREs", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "CHEBI:70762", "map_id": "CHEBI:70762", "name": "CHEBI:70762", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:70760", "map_id": "CHEBI:70760", "name": "CHEBI:70760", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "CHEBI:70761", "map_id": "CHEBI:70761", "name": "CHEBI:70761", "type": "complex_component", "sub_type": "metabolite_component", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "species_2864103", "map_id": "none", "name": "FAs", "type": "product", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_13977", "compartment_display": "lipid droplet", "complex": "true" }, { "id": "species_10465830", "map_id": "Q9VFS2", "name": "ninaB", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_876", "compartment_display": "plasma membrane", "complex": "false" }, { "id": "species_10465836", "map_id": "Q9V3Z6", "name": "ck", "type": "catalyst", "sub_type": "protein_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "FBgn0000317", "map_id": "FBgn0000317", "name": "ck", "type": "gene_component", "sub_type": "gene", "inferred": "false", "compartment": "none", "compartment_display": "none" }, { "id": "reaction_10465854", "map_id": "none", "name": "11cROL binds to RLBP1 to form RLBP1:11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "species_10431865", "map_id": "none", "name": "RLBP1:11cRAL", "type": "reactant", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "true" }, { "id": "species_8960974", "map_id": "CHEBI:16066", "name": "11cRAL", "type": "product", "sub_type": "metabolite_component", "inferred": "false", "compartment": "compartment_70101", "compartment_display": "cytosol", "complex": "false" }, { "id": "species_10431897", "map_id": "none", "name": "Homologues of RDH10", "type": "catalyst", "sub_type": "complex_component", "inferred": "false", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane", "complex": "true" }, { "id": "reaction_10465852", "map_id": "none", "name": "RDH5 oxidises 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_12045", "compartment_display": "endoplasmic reticulum membrane" }, { "id": "reaction_10495347", "map_id": "none", "name": "RLBP1:11cRAL dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "type": "reaction", "sub_type": "reaction", "compartment": "compartment_70101", "compartment_display": "cytosol" }, { "id": "reaction_10431849", "map_id": "none", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"type": "complex_component", "sub_type": "metabolite_component", "source": "species_74016", "target": "species_10461151" }, { "type": "reactant", "sub_type": "metabolite_component", "source": "species_74016", "target": "reaction_10448158" }, { "type": "reactant", "sub_type": "metabolite_component", "source": "species_74016", "target": "reaction_10448150" }, { "type": "complex_component", "sub_type": "metabolite_component", "source": "species_74016", "target": "species_10469032" }, { "type": "complex_component", "sub_type": "metabolite_component", "source": "species_74016", "target": "species_10469040" }, { "type": "complex_component", "sub_type": "metabolite_component", "source": "species_74016", "target": "species_10469036" }, { "type": "complex_component", "sub_type": "metabolite_component", "source": "species_74016", "target": "species_10469702" }, { "type": "complex_component", "sub_type": "metabolite_component", "source": "species_74016", "target": "species_10469697" }, { "type": 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10497649" ], "products": [ "species_10497651" ], "modifiers": [], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "FBgn0016126", "Q7JMV3", "FBgn0016126", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10435736": { "compartment": "compartment_70101", "id": "reaction_10435736", "reactome": "R-DME-159050", "name": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435730", "species_10430485" ], "products": [ "species_10432289", "species_10435734", "species_10432313" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "Q9VAN6", "FBgn0041186", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "FBgn0003321", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VAN6", "FBgn0041186", "FBgn0010774", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10433271": { "compartment": "compartment_7660", "id": "reaction_10433271", "reactome": "R-DME-77587", "name": "Docking of Mature Replication Dependent Histone mRNA with the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433265", "species_10429500", "species_10432253" ], "products": [ "species_10433269", "species_10429162", "species_10429167" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "FBgn0010774", "FBgn0003321", "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9VAN6", "FBgn0041186", "FBgn0022943", "FBgn0022942", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435732": { "compartment": "compartment_13231", "id": "reaction_10435732", "reactome": "R-DME-159046", "name": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440773", "species_113592" ], "products": [ "species_29370", "species_10440775", "species_10433704" ], "modifiers": [ [ "species_10440773", "catalyst" ] ], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838", "Q8INB9", "phospho-Akt1", "Q9W0V1", "Pdk1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "Q8INB9", "phospho-Akt1" ] }, "reaction_10471692": { "compartment": "compartment_876", "id": "reaction_10471692", "reactome": "R-DME-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471687" ], "products": [ "species_10447061", "species_29370", "species_10471000" ], "modifiers": [ [ "species_10446523", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10465531": { "compartment": "compartment_876", "id": "reaction_10465531", "reactome": "R-DME-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440771", "species_10433704" ], "products": [ "species_10440773" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "Q8INB9", "phospho-Akt1" ] }, "reaction_10471689": { "compartment": "compartment_876", "id": "reaction_10471689", "reactome": "R-DME-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471685" ], "products": [ "species_10471687" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10471703": { "compartment": "compartment_876", "id": "reaction_10471703", "reactome": "R-DME-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471000", "species_10446523" ], "products": [ "species_10471685" ], "modifiers": [], "additional_components": [ "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10471701": { "compartment": "compartment_876", "id": "reaction_10471701", "reactome": "R-DME-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471694" ], "products": [ "species_10471699", "species_29370" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q9VJB6", "FBgn0262018", "Q7PLI0", "FBgn0260799", "P18824", "arm", "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q7PLI0", "FBgn0260799", "Q9VJB6", "FBgn0262018", "P18824", "arm", "FBgn0267698" ] }, "reaction_10441860": { "compartment": "compartment_70101", "id": "reaction_10441860", "reactome": "R-DME-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10441857", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10465459": { "compartment": "compartment_70101", "id": "reaction_10465459", "reactome": "R-DME-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10441880" ], "products": [ "species_10433704" ], "modifiers": [], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10459875": { "compartment": "compartment_70101", "id": "reaction_10459875", "reactome": "R-DME-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10441853" ], "products": [ "species_10441857" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10440881": { "compartment": "compartment_70101", "id": "reaction_10440881", "reactome": "R-DME-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440860" ], "products": [ "species_10440771", "species_29370" ], "modifiers": [ [ "species_10440874", "catalyst" ], [ "species_10440879", "inhibitor" ] ], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "Q8INB9", "phospho-Akt1", "species_179838", "Q9VK45", "FBgn0021796", "Q9V719", "FBgn0033935", "Q9W328", "FBgn0264691", "Q9VWJ6", "FBgn0031006", "Q9V3Z1", "FBgn0028978", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10441872": { "compartment": "compartment_70101", "id": "reaction_10441872", "reactome": "R-DME-202137", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441840", "species_10440775" ], "products": [ "species_10441844" ], "modifiers": [], "additional_components": [ "P02828", "FBgn0001233", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "species_74016", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "species_74016" ] }, "reaction_10470966": { "compartment": "compartment_876", "id": "reaction_10470966", "reactome": "R-DME-5218819", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10470963", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10493673": { "compartment": "compartment_876", "id": "reaction_10493673", "reactome": "R-DME-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464321", "species_10470968" ], "products": [ "species_10470998" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "Q9NHV9", "FBgn0040068", "species_179838", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29420" ] }, "reaction_10470996": { "compartment": "compartment_876", "id": "reaction_10470996", "reactome": "R-DME-5218847", "name": "PAK2 binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470880", "species_10446517" ], "products": [ "species_10470985" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10470961": { "compartment": "compartment_876", "id": "reaction_10470961", "reactome": "R-DME-5218814", "name": "PAK2 autophorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470958" ], "products": [ "species_10470947", "species_29370" ], "modifiers": [ [ "species_10470958", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10439437": { "compartment": "compartment_70101", "id": "reaction_10439437", "reactome": "R-DME-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439409", "species_113592" ], "products": [ "species_29370", "species_10439416" ], "modifiers": [ [ "species_10439434", "catalyst" ] ], "additional_components": [ "FBgn0013987", "FBgn0013987", "species_29926", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765" ] }, "reaction_10471021": { "compartment": "compartment_70101", "id": "reaction_10471021", "reactome": "R-DME-5218916", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471014" ], "products": [ "species_10449184", "species_29370", "species_10471019" ], "modifiers": [ [ "species_10439416", "catalyst" ] ], "additional_components": [ "Q8IQW5", "FBgn0031037", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "FBgn0031037", "FBgn0013987" ] }, "reaction_10470892": { "compartment": "compartment_70101", "id": "reaction_10470892", "reactome": "R-DME-5218804", "name": "p38 MAPK activation by VEGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451571", "species_113592" ], "products": [ "species_29370", "species_10439434" ], "modifiers": [ [ "species_10470889", "catalyst" ] ], "additional_components": [ "species_29926", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "species_29926", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10470987": { "compartment": "compartment_876", "id": "reaction_10470987", "reactome": "R-DME-5218832", "name": "CDC42:GTP binds PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439139", "species_10470985" ], "products": [ "species_10470958" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "B7Z0W0", "FBgn0267698", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10469449": { "compartment": "compartment_876", "id": "reaction_10469449", "reactome": "R-DME-3928647", "name": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604", "species_10434906" ], "products": [ "species_10447647" ], "modifiers": [], "additional_components": [ "FBgn0026181", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181" ] }, "reaction_10464390": { "compartment": "compartment_876", "id": "reaction_10464390", "reactome": "R-DME-2029465", "name": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067", "species_10464386", "species_10464339", "species_179838" ], "products": [ "species_10464388" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "FBgn0052082", "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10470950": { "compartment": "compartment_876", "id": "reaction_10470950", "reactome": "R-DME-5218812", "name": "FYN phosphorylates PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470947", "species_113592" ], "products": [ "species_29370", "species_10470889" ], "modifiers": [ [ "species_10470947", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10471107": { "compartment": "compartment_70101", "id": "reaction_10471107", "reactome": "R-DME-5228992", "name": "ROCK1,ROCK2 are activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447647" ], "products": [ "species_10471105" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181", "species_29926", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181" ] }, "reaction_10471008": { "compartment": "compartment_70101", "id": "reaction_10471008", "reactome": "R-DME-5218854", "name": "p-Y420-FYN is phosphorylated on S21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470938" ], "products": [ "species_10470880", "species_29370" ], "modifiers": [ [ "species_10471005", "catalyst" ] ], "additional_components": [ "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_209235": { "compartment": "compartment_13231", "id": "reaction_209235", "reactome": "R-DME-209235", "name": "Phosphorylated BSK kinase transports from the cytosol to the nucleus", "reversible": "false", "notes": "Free phosphorylated Basket (BSK) kinase is now able to translocate from the cytosol to the nucleus.", "reactants": [ "species_206213" ], "products": [ "species_206300" ], "modifiers": [], "additional_components": [] }, "reaction_209330": { "compartment": "compartment_7660", "id": "reaction_209330", "reactome": "R-DME-209330", "name": "Phosphorylated BSK kinase and the AP-1 transcription factor, JRA:KAY, bind to CKA scaffolding protein in the nucleus", "reversible": "false", "notes": "In the nucleus, another molecule of the scaffolding protein CKA binds the phosphorylated Basket (BSK) kinase and the AP-1 transcription factor heterodimer. The latter is made up of the c-Jun ortholgue, Jun-related antigen (JRA) and the c-Fos orthologue, Kayak (KAY).", "reactants": [ "species_206300", "species_205983", "species_206724" ], "products": [ "species_207020" ], "modifiers": [], "additional_components": [ "P21525", "phospho-kay", "P18289", "phospho-Jra", "P21525", "phospho-kay", "P18289", "phospho-Jra", "Q9VLT9", "CKA", "P92208", "bsk" ] }, "reaction_209381": { "compartment": "compartment_7660", "id": "reaction_209381", "reactome": "R-DME-209381", "name": "AP-1 transcription factor, JRA:KAY, is phosphorylated by phosphorylated BSK kinase", "reversible": "false", "notes": "Phosphorylated Basket (BSK) kinase phosphorylates residues Ser82 and Ser92 on JRA along with residues Thr216 and Thr220 on KAY.", "reactants": [ "species_207020", "species_29358" ], "products": [ "species_113582", "species_206830" ], "modifiers": [ [ "species_207020", "catalyst" ] ], "additional_components": [ "P21525", "phospho-kay", "P18289", "phospho-Jra", "Q9VLT9", "CKA", "P92208", "bsk", "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q9VLT9", "CKA", "P92208", "bsk", "P21525", "phospho-kay", "P18289", "phospho-Jra", "Q9VLT9", "CKA", "P92208", "bsk" ] }, "reaction_209193": { "compartment": "compartment_7660", "id": "reaction_209193", "reactome": "R-DME-209193", "name": "Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA", "reversible": "false", "notes": "The phosphorylated AP-1 transcription factor, JRA:KAY dissociates from the scaffolding protein CKA.", "reactants": [ "species_206830" ], "products": [ "species_206892", "species_206657" ], "modifiers": [], "additional_components": [ "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q9VLT9", "CKA", "P92208", "bsk", "Q9VLT9", "CKA", "P92208", "bsk", "P18289", "phospho-Jra", "P21525", "phospho-kay" ] }, "reaction_209358": { "compartment": "compartment_7660", "id": "reaction_209358", "reactome": "R-DME-209358", "name": "Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription", "reversible": "false", "notes": "The phosphorylated AP-1 transcription factor binds to its target genes and activates transcription. One of its target genes encodes the phosphatase Puckered (PUC) which acts as a negative regulator of the pathway as part of a negative feedback loop.In the eye, another transcriptional target, arising from the Frizzled (FZ):Dishevelled (DSH) complex activation in R3 cells, is for the Notch (N) receptor ligand Delta (DL). This will subsequently bind to its receptor N in the neighbouring R4 cell.", "reactants": [ "species_206657" ], "products": [ "species_206657" ], "modifiers": [], "additional_components": [ "P18289", "phospho-Jra", "P21525", "phospho-kay", "P18289", "phospho-Jra", "P21525", "phospho-kay" ] }, "reaction_209298": { "compartment": "compartment_70101", "id": "reaction_209298", "reactome": "R-DME-209298", "name": "BSK is phosphorylated and activated by phosphorylated HEP kinase", "reversible": "false", "notes": "Basket (BSK) is phosphorylated and activated when residues Thr181 and Tyr183 (Thr183 an Tyr185 in human JNK1) are phosphorylated by dual-specificity kinase, Hemipterous (HEP).", "reactants": [ "species_206638", "species_113592" ], "products": [ "species_29370", "species_206913" ], "modifiers": [ [ "species_206638", "catalyst" ] ], "additional_components": [ "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA", "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA", "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA" ] }, "reaction_209302": { "compartment": "compartment_70101", "id": "reaction_209302", "reactome": "R-DME-209302", "name": "Phosphorylated BSK kinase dissociates from CKA scaffolding protein", "reversible": "false", "notes": "The phosphorylation of the scaffold protein CKA probably results in a conformational change resulting in the dissociation of the phosphorylated Basket (BSK) kinase.", "reactants": [ "species_206943" ], "products": [ "species_206789", "species_206213" ], "modifiers": [], "additional_components": [ "Q23977", "Phospho HEP", "Q9VLT9", "CKA", "P92208", "bsk", "Q23977", "Phospho HEP", "Q9VLT9", "CKA" ] }, "reaction_209157": { "compartment": "compartment_70101", "id": "reaction_209157", "reactome": "R-DME-209157", "name": "Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase", "reversible": "false", "notes": "The JUN kinase phosphatase Puckered (PUC) dephosphorylates and consequently deactivates the phosphorylated Basket (BSK) kinase. The gene that encodes PUC is a target of the AP-1 transcription factor making this interaction part of a regulatory negative feedback loop.", "reactants": [ "species_206213" ], "products": [ "species_29372", "species_206251" ], "modifiers": [ [ "species_205899", "catalyst" ] ], "additional_components": [] }, "reaction_209183": { "compartment": "compartment_70101", "id": "reaction_209183", "reactome": "R-DME-209183", "name": "Scaffolding protein CKA binds BSK and phosphorylated HEP kinases", "reversible": "false", "notes": "The multidomain scaffolding protein, connector of kinase to AP-1 (CKA) binds phosphorylated Hemipterous (HEP) and the MAP kinase/JNK orthologue, Basket (BSK).", "reactants": [ "species_205833", "species_206251", "species_205776" ], "products": [ "species_206638" ], "modifiers": [], "additional_components": [ "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA" ] }, "reaction_209199": { "compartment": "compartment_70101", "id": "reaction_209199", "reactome": "R-DME-209199", "name": "CKA is phosphorylated by phosphorylated BSK kinase", "reversible": "false", "notes": "The scaffolding protein CKA is phosphorylated by phosphorylated Basket (BSK) kinase.", "reactants": [ "species_113592", "species_206913" ], "products": [ "species_206943", "species_29370" ], "modifiers": [ [ "species_206913", "catalyst" ] ], "additional_components": [ "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA", "Q23977", "Phospho HEP", "Q9VLT9", "CKA", "P92208", "bsk", "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA" ] }, "reaction_10439486": { "compartment": "compartment_7660", "id": "reaction_10439486", "reactome": "R-DME-188371", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438214", "species_10427405" ], "products": [ "species_10438216" ], "modifiers": [], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438221": { "compartment": "compartment_7660", "id": "reaction_10438221", "reactome": "R-DME-174079", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438216" ], "products": [ "species_113582", "species_10438218" ], "modifiers": [ [ "species_10438216", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438380": { "compartment": "compartment_7660", "id": "reaction_10438380", "reactome": "R-DME-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438212" ], "products": [ "species_113582", "species_10438066" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "FBgn0262699", "FBgn0262699", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10435471": { "compartment": "compartment_70101", "id": "reaction_10435471", "reactome": "R-DME-141423", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427579", "species_10435467" ], "products": [ "species_10435469" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10435477": { "compartment": "compartment_70101", "id": "reaction_10435477", "reactome": "R-DME-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435460", "species_10435465", "species_10435450", "species_10435455" ], "products": [ "species_10435467" ], "modifiers": [], "additional_components": [ "FBgn0001086", "FBgn0035640", "FBgn0263855", "FBgn0025457", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086" ] }, "reaction_10435475": { "compartment": "compartment_70101", "id": "reaction_10435475", "reactome": "R-DME-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435460", "species_10435465" ], "products": [ "species_10435473" ], "modifiers": [], "additional_components": [ "FBgn0001086", "FBgn0035640", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086" ] }, "reaction_10438247": { "compartment": "compartment_7660", "id": "reaction_10438247", "reactome": "R-DME-174097", "name": "Association of Emi1 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438243", "species_10436108" ], "products": [ "species_10438245" ], "modifiers": [], "additional_components": [ "Q9W4H9", "FBgn0262699", "FBgn0017551", "Q9VM76", "FBgn0017551", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438310": { "compartment": "compartment_7660", "id": "reaction_10438310", "reactome": "R-DME-174139", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438102" ], "products": [ "species_10438066", "species_10438100" ], "modifiers": [], "additional_components": [ "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438374": { "compartment": "compartment_7660", "id": "reaction_10438374", "reactome": "R-DME-174235", "name": "Association of Emi1 with Cdc20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438282", "species_10436108" ], "products": [ "species_10438372" ], "modifiers": [], "additional_components": [ "FBgn0001086", "FBgn0017551", "Q9VM76", "FBgn0017551", "Q24044", "FBgn0001086" ] }, "reaction_10438361": { "compartment": "compartment_7660", "id": "reaction_10438361", "reactome": "R-DME-174174", "name": "Phosphorylation of the Emi1 DSGxxS degron by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438286" ], "products": [ "species_113582", "species_10438359" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "Q9VM76", "FBgn0017551", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q9VM76", "FBgn0017551", "FBgn0003124" ] }, "reaction_10438294": { "compartment": "compartment_7660", "id": "reaction_10438294", "reactome": "R-DME-174122", "name": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438286" ], "products": [ "species_113582", "species_10438291" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q9VM76", "FBgn0017551", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q9VM76", "FBgn0017551", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10438382": { "compartment": "compartment_70101", "id": "reaction_10438382", "reactome": "R-DME-174255", "name": "Degradation multiubiquitinated Cyclin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438253" ], "products": [ "species_10434593", "species_10426987", "species_10435469" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106", "FBgn0004106", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10438355": { "compartment": "compartment_70101", "id": "reaction_10438355", "reactome": "R-DME-174171", "name": "Association of Cyclin A with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438249", "species_10435469" ], "products": [ "species_10438251" ], "modifiers": [], "additional_components": [ "P23572", "FBgn0004106", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106" ] }, "reaction_10438256": { "compartment": "compartment_70101", "id": "reaction_10438256", "reactome": "R-DME-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10438251" ], "products": [ "species_10438253" ], "modifiers": [ [ "species_10435469", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10439023": { "compartment": "compartment_70101", "id": "reaction_10439023", "reactome": "R-DME-179417", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439016", "species_10426987" ], "products": [ "species_10439020" ], "modifiers": [ [ "species_10439016", "catalyst" ] ], "additional_components": [ "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970" ] }, "reaction_10439018": { "compartment": "compartment_70101", "id": "reaction_10439018", "reactome": "R-DME-179410", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439014", "species_10435469" ], "products": [ "species_10439016" ], "modifiers": [], "additional_components": [ "FBgn0029970", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970" ] }, "reaction_10439025": { "compartment": "compartment_70101", "id": "reaction_10439025", "reactome": "R-DME-179421", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439020" ], "products": [ "species_10426987", "species_10435469" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10438378": { "compartment": "compartment_70101", "id": "reaction_10438378", "reactome": "R-DME-174238", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435469" ], "products": [ "species_10438276", "species_10438376" ], "modifiers": [], "additional_components": [ "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640" ] }, "reaction_10438280": { "compartment": "compartment_70101", "id": "reaction_10438280", "reactome": "R-DME-174120", "name": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438276", "species_10437675" ], "products": [ "species_10438278" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086" ] }, "reaction_10438325": { "compartment": "compartment_70101", "id": "reaction_10438325", "reactome": "R-DME-174157", "name": "Degradation of multiubiquitinated Cyclin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438323" ], "products": [ "species_10434593", "species_10438276", "species_10426987" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "FBgn0004106", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10438370": { "compartment": "compartment_70101", "id": "reaction_10438370", "reactome": "R-DME-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438278", "species_10426987" ], "products": [ "species_10438323" ], "modifiers": [ [ "species_10438276", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086" ] }, "reaction_10438366": { "compartment": "compartment_70101", "id": "reaction_10438366", "reactome": "R-DME-174202", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438318" ], "products": [ "species_10438276", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10438321": { "compartment": "compartment_70101", "id": "reaction_10438321", "reactome": "R-DME-174144", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438314", "species_10426987" ], "products": [ "species_10438318" ], "modifiers": [ [ "species_10438276", "catalyst" ] ], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086" ] }, "reaction_10438308": { "compartment": "compartment_7660", "id": "reaction_10438308", "reactome": "R-DME-174132", "name": "Free APC/C phosphorylated by Cyclin B:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438100" ], "products": [ "species_10438100" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10438274": { "compartment": "compartment_7660", "id": "reaction_10438274", "reactome": "R-DME-174119", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438100" ], "products": [ "species_10438100" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "FBgn0003124" ] }, "reaction_10438107": { "compartment": "compartment_7660", "id": "reaction_10438107", "reactome": "R-DME-174057", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10438102" ], "products": [ "species_10438104" ], "modifiers": [ [ "species_10438102", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438208": { "compartment": "compartment_7660", "id": "reaction_10438208", "reactome": "R-DME-174058", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438104" ], "products": [ "species_10438100", "species_10427430" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10438306": { "compartment": "compartment_70101", "id": "reaction_10438306", "reactome": "R-DME-174124", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10438296" ], "products": [ "species_111294", "species_10427584" ], "modifiers": [ [ "species_10438303", "catalyst" ] ], "additional_components": [ "FBgn0262699", "FBgn0262699" ] }, "reaction_10438210": { "compartment": "compartment_70101", "id": "reaction_10438210", "reactome": "R-DME-174070", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427584", "species_10427579" ], "products": [ "species_10427586" ], "modifiers": [], "additional_components": [ "FBgn0262699", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438368": { "compartment": "compartment_70101", "id": "reaction_10438368", "reactome": "R-DME-174224", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438276" ], "products": [ "species_10435460", "species_10427579" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10498544": { "compartment": "compartment_7660", "id": "reaction_10498544", "reactome": "R-DME-9686969", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498541", "species_10427430" ], "products": [ "species_10439482" ], "modifiers": [ [ "species_10498541", "catalyst" ] ], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438364": { "compartment": "compartment_70101", "id": "reaction_10438364", "reactome": "R-DME-174195", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10438239" ], "products": [ "species_10438258" ], "modifiers": [ [ "species_10438239", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438260": { "compartment": "compartment_70101", "id": "reaction_10438260", "reactome": "R-DME-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438258" ], "products": [ "species_10427586", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10438241": { "compartment": "compartment_70101", "id": "reaction_10438241", "reactome": "R-DME-174088", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427586", "species_10438237" ], "products": [ "species_10438239" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699" ] }, "reaction_10472877": { "compartment": "compartment_70101", "id": "reaction_10472877", "reactome": "R-DME-5607722", "name": "Active NIK phosphorylates IKKA dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10472874", "species_10446829" ], "products": [ "species_29370", "species_10472862" ], "modifiers": [ [ "species_10446829", "catalyst" ] ], "additional_components": [ "Q9VEZ5", "phospho-IKKbeta", "FBgn0024329", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "FBgn0024329" ] }, "reaction_10472872": { "compartment": "compartment_70101", "id": "reaction_10472872", "reactome": "R-DME-5607721", "name": "Activation of NIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446829" ], "products": [ "species_10446829" ], "modifiers": [], "additional_components": [ "FBgn0024329", "FBgn0024329" ] }, "reaction_10472920": { "compartment": "compartment_70101", "id": "reaction_10472920", "reactome": "R-DME-5607731", "name": "26S proteasome processes p-7S-p100:RELB to form p52:RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472913" ], "products": [ "species_10472918", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "P15330", "dl", "Q94527", "Rel", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10472935": { "compartment": "compartment_7660", "id": "reaction_10472935", "reactome": "R-DME-5607741", "name": "p52:RELB translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472918" ], "products": [ "species_10472933" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P15330", "dl", "Q94527", "Rel", "P15330", "dl" ] }, "reaction_10472870": { "compartment": "compartment_70101", "id": "reaction_10472870", "reactome": "R-DME-5607720", "name": "p100:RELB binds active NIK:p-IKKA dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472866", "species_10472862" ], "products": [ "species_10472868" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P15330", "dl", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl" ] }, "reaction_10472916": { "compartment": "compartment_70101", "id": "reaction_10472916", "reactome": "R-DME-5607726", "name": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472868", "species_113592" ], "products": [ "species_29370", "species_10472890" ], "modifiers": [ [ "species_10472868", "catalyst" ] ], "additional_components": [ "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl" ] }, "reaction_10475005": { "compartment": "compartment_70101", "id": "reaction_10475005", "reactome": "R-DME-5654573", "name": "Activated FGFR1 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465461", "species_10474909" ], "products": [ "species_10475003" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475036": { "compartment": "compartment_70101", "id": "reaction_10475036", "reactome": "R-DME-5654600", "name": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475031", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296" ] }, "reaction_10475033": { "compartment": "compartment_876", "id": "reaction_10475033", "reactome": "R-DME-5654597", "name": "Activated FGFR1:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475013" ], "products": [ "species_10475031" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296" ] }, "reaction_10475016": { "compartment": "compartment_70101", "id": "reaction_10475016", "reactome": "R-DME-5654582", "name": "Activated FGFR1 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475003" ], "products": [ "species_29370", "species_10475013" ], "modifiers": [ [ "species_10475003", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10434311": { "compartment": "compartment_70101", "id": "reaction_10434311", "reactome": "R-DME-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434307" ], "products": [ "species_10434309", "species_10434303" ], "modifiers": [], "additional_components": [ "species_30389", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "species_30389", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10433343": { "compartment": "compartment_5460", "id": "reaction_10433343", "reactome": "R-DME-109338", "name": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77358" ], "products": [ "species_77360" ], "modifiers": [ [ "species_10433340", "catalyst" ] ], "additional_components": [ "Q9VL68", "FBgn0032160" ] }, "reaction_10433820": { "compartment": "compartment_5460", "id": "reaction_10433820", "reactome": "R-DME-109998", "name": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109994" ], "products": [ "species_77343" ], "modifiers": [ [ "species_10433340", "catalyst" ] ], "additional_components": [ "Q9VL68", "FBgn0032160" ] }, "reaction_10433345": { "compartment": "compartment_5460", "id": "reaction_10433345", "reactome": "R-DME-109341", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_109986" ], "products": [ "species_109990", "species_31649" ], "modifiers": [ [ "species_10433219", "catalyst" ] ], "additional_components": [ "Q9VSA3", "FBgn0035811" ] }, "reaction_10469608": { "compartment": "compartment_7660", "id": "reaction_10469608", "reactome": "R-DME-4085372", "name": "PIAS1 SUMOylates SAFB with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469602", "species_10467300" ], "products": [ "species_10467222", "species_10469606" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0039229", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "FBgn0039229", "FBgn0003612" ] }, "reaction_10469156": { "compartment": "compartment_7660", "id": "reaction_10469156", "reactome": "R-DME-3900194", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429510", "species_10467290" ], "products": [ "species_10469153", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0035720", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0035720", "FBgn0010602", "FBgn0003612" ] }, "reaction_10467491": { "compartment": "compartment_7660", "id": "reaction_10467491", "reactome": "R-DME-3108203", "name": "PRC1 SUMOylates CTBP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10467421" ], "products": [ "species_10467424", "species_10467222" ], "modifiers": [ [ "species_10467488", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0020496", "FBgn0020496", "FBgn0010602", "P26017", "FBgn0003042", "Q9VB08", "FBgn0003330", "Q9VHA0", "FBgn0003334", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "P39769", "FBgn0004861", "Q9VKL0", "FBgn0032330", "Q9W523", "FBgn0004860" ] }, "reaction_10469619": { "compartment": "compartment_7660", "id": "reaction_10469619", "reactome": "R-DME-4086059", "name": "SUMOylation of NPM1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469613" ], "products": [ "species_10469616", "species_10467222" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0016685", "FBgn0016685", "FBgn0010602", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10471853": { "compartment": "compartment_7660", "id": "reaction_10471853", "reactome": "R-DME-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427633", "species_10471849", "species_10471835" ], "products": [ "species_10471851" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655" ] }, "reaction_10471868": { "compartment": "compartment_7660", "id": "reaction_10471868", "reactome": "R-DME-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_5358610" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10427699", "catalyst" ] ], "additional_components": [ "FBgn0262619" ] }, "reaction_10471882": { "compartment": "compartment_7660", "id": "reaction_10471882", "reactome": "R-DME-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10471862" ], "products": [ "species_113582", "species_10471849" ], "modifiers": [], "additional_components": [ "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546" ] }, "reaction_10471864": { "compartment": "compartment_7660", "id": "reaction_10471864", "reactome": "R-DME-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471860", "species_5358514" ], "products": [ "species_10471862" ], "modifiers": [], "additional_components": [ "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370", "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370" ] }, "reaction_10471880": { "compartment": "compartment_7660", "id": "reaction_10471880", "reactome": "R-DME-5358599", "name": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_10471875" ], "products": [ "species_10471866" ], "modifiers": [ [ "species_10471875", "catalyst" ] ], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "Q24558", "FBgn0015553", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "Q24558", "FBgn0015553" ] }, "reaction_10471877": { "compartment": "compartment_7660", "id": "reaction_10471877", "reactome": "R-DME-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471873", "species_10471855" ], "products": [ "species_10471875" ], "modifiers": [], "additional_components": [ "FBgn0015553", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "Q24558", "FBgn0015553" ] }, "reaction_10472562": { "compartment": "compartment_7660", "id": "reaction_10472562", "reactome": "R-DME-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471828", "species_10471833" ], "products": [ "species_10471835" ], "modifiers": [], "additional_components": [ "FBgn0011659", "FBgn0011660", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659" ] }, "reaction_10471858": { "compartment": "compartment_7660", "id": "reaction_10471858", "reactome": "R-DME-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471851" ], "products": [ "species_10471855" ], "modifiers": [ [ "species_10471851", "catalyst" ] ], "additional_components": [ "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655" ] }, "reaction_10472560": { "compartment": "compartment_7660", "id": "reaction_10472560", "reactome": "R-DME-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10471840", "species_10471845" ], "products": [ "species_10471860" ], "modifiers": [], "additional_components": [ "FBgn0015546", "FBgn0036486", "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370" ] }, "reaction_10473069": { "compartment": "compartment_70101", "id": "reaction_10473069", "reactome": "R-DME-5610737", "name": "NUMB:ITCH bind and ubiquitnate GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473061", "species_10473055" ], "products": [ "species_10473066" ], "modifiers": [ [ "species_10473055", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9VG38", "FBgn0005355", "P19538", "ci", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10473111": { "compartment": "compartment_70101", "id": "reaction_10473111", "reactome": "R-DME-5610760", "name": "GLI1 is degraded by the proteasome after ubiquitination by ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473066" ], "products": [ "species_10472994", "species_10473055" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0005355", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10473109": { "compartment": "compartment_70101", "id": "reaction_10473109", "reactome": "R-DME-5610758", "name": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473071" ], "products": [ "species_10472994" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0005355", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10473073": { "compartment": "compartment_5263232", "id": "reaction_10473073", "reactome": "R-DME-5610742", "name": "SCF(beta-TrCP) ubiquitinates p-GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473061", "species_10426987" ], "products": [ "species_10473071" ], "modifiers": [ [ "species_10442677", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10473057": { "compartment": "compartment_70101", "id": "reaction_10473057", "reactome": "R-DME-5610735", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456470", "species_10473053" ], "products": [ "species_10473055" ], "modifiers": [], "additional_components": [ "FBgn0003557", "FBgn0002973", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10491420": { "compartment": "compartment_70101", "id": "reaction_10491420", "reactome": "R-DME-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10491417", "catalyst" ] ], "additional_components": [ "FBgn0023522" ] }, "reaction_10456032": { "compartment": "compartment_70101", "id": "reaction_10456032", "reactome": "R-DME-977301", "name": "Histidine is decarboxylated to histamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_175992", "species_113528" ], "modifiers": [ [ "species_10456029", "catalyst" ] ], "additional_components": [ "Q05733", "FBgn0005619" ] }, "reaction_10464665": { "compartment": "compartment_984", "id": "reaction_10464665", "reactome": "R-DME-2046239", "name": "Extracellular KSPG translocates to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464621" ], "products": [ "species_10461390" ], "modifiers": [], "additional_components": [ "FBgn0028872", "FBgn0028872" ] }, "reaction_10460806": { "compartment": "compartment_161320", "id": "reaction_10460806", "reactome": "R-DME-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10460515", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10497913": { "compartment": "compartment_161320", "id": "reaction_10497913", "reactome": "R-DME-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10460517", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10460725": { "compartment": "compartment_161320", "id": "reaction_10460725", "reactome": "R-DME-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104997" ], "products": [ "species_1605637", "species_2104995" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_10460803": { "compartment": "compartment_161320", "id": "reaction_10460803", "reactome": "R-DME-1638032", "name": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104995" ], "products": [ "species_1606845", "species_2105012" ], "modifiers": [ [ "species_10460800", "catalyst" ] ], "additional_components": [ "FBgn0033836" ] }, "reaction_10453964": { "compartment": "compartment_20699", "id": "reaction_10453964", "reactome": "R-DME-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744229", "species_735698" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10453959", "catalyst" ] ], "additional_components": [ "species_744227", "species_914003", "species_744227", "species_914003", "FBgn0042641" ] }, "reaction_10464619": { "compartment": "compartment_20699", "id": "reaction_10464619", "reactome": "R-DME-2046175", "name": "Further sulfation on galactose residues produces KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10464596" ], "products": [ "species_742343", "species_10464606" ], "modifiers": [ [ "species_10464616", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "FBgn0051637" ] }, "reaction_10463991": { "compartment": "compartment_20699", "id": "reaction_10463991", "reactome": "R-DME-2025724", "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10463960" ], "products": [ "species_10463973", "species_205687" ], "modifiers": [ [ "species_10463988", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q95RP8", "FBgn0040373", "A1Z8R6", "FBgn0053145", "A1Z8R5", "FBgn0050037", "A1Z8R4", "FBgn0050036", "Q9VZA6", "FBgn0035558", "Q9VLT0", "FBgn0031986", "Q9VLS8", "FBgn0031988", "Q9W1A7", "FBgn0041706" ] }, "reaction_10464663": { "compartment": "compartment_20699", "id": "reaction_10464663", "reactome": "R-DME-2046222", "name": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10464634" ], "products": [ "species_742343", "species_10464596" ], "modifiers": [ [ "species_10464660", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VMC4", "FBgn0031826", "Q9VMC3", "FBgn0051637" ] }, "reaction_10464631": { "compartment": "compartment_17963", "id": "reaction_10464631", "reactome": "R-DME-2046180", "name": "KSPG is secreted from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464606" ], "products": [ "species_10464621" ], "modifiers": [], "additional_components": [ "FBgn0028872", "FBgn0028872" ] }, "reaction_10464678": { "compartment": "compartment_20699", "id": "reaction_10464678", "reactome": "R-DME-2046265", "name": "B4GALTs transfer Gal to the keratan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463973", "species_735682" ], "products": [ "species_205687", "species_10464668" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10464691": { "compartment": "compartment_20699", "id": "reaction_10464691", "reactome": "R-DME-2046298", "name": "B4GALTs transfer Gal to a branch of keratan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10464668" ], "products": [ "species_10464681", "species_205687" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10463970": { "compartment": "compartment_20699", "id": "reaction_10463970", "reactome": "R-DME-2025723", "name": "B4GALTs transfer Gal to the N-glycan precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10463949" ], "products": [ "species_10463960", "species_205687" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10440396": { "compartment": "compartment_70101", "id": "reaction_10440396", "reactome": "R-DME-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440394": { "compartment": "compartment_70101", "id": "reaction_10440394", "reactome": "R-DME-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440392": { "compartment": "compartment_70101", "id": "reaction_10440392", "reactome": "R-DME-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9617026" ], "products": [ "species_193829", "species_29366" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440390": { "compartment": "compartment_70101", "id": "reaction_10440390", "reactome": "R-DME-193816", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192194" ], "products": [ "species_70106", "species_193835", "species_73473" ], "modifiers": [ [ "species_10440112", "catalyst" ] ], "additional_components": [ "FBgn0036698" ] }, "reaction_10440388": { "compartment": "compartment_70101", "id": "reaction_10440388", "reactome": "R-DME-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10434826": { "compartment": "compartment_7660", "id": "reaction_10434826", "reactome": "R-DME-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427460" ], "products": [ "species_113656", "species_10427272" ], "modifiers": [], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113" ] }, "reaction_10439755": { "compartment": "compartment_984", "id": "reaction_10439755", "reactome": "R-DME-190265", "name": "FGFR4 binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439749", "species_10433467", "species_190915" ], "products": [ "species_10439753" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10458927": { "compartment": "compartment_876", "id": "reaction_10458927", "reactome": "R-DME-1307963", "name": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10458922" ], "products": [ "species_10433616", "species_29370" ], "modifiers": [ [ "species_10458922", "catalyst" ] ], "additional_components": [ "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10458924": { "compartment": "compartment_70101", "id": "reaction_10458924", "reactome": "R-DME-1307955", "name": "FGFR4 binds HS:KLB:FGF19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439749", "species_10433610", "species_190915", "species_10433614" ], "products": [ "species_10458922" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "FBgn0036659", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10439762": { "compartment": "compartment_876", "id": "reaction_10439762", "reactome": "R-DME-190326", "name": "Autocatalytic phosphorylation of FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439753" ], "products": [ "species_29370", "species_10433612" ], "modifiers": [ [ "species_10439753", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474842": { "compartment": "compartment_876", "id": "reaction_10474842", "reactome": "R-DME-5654163", "name": "Activated FGFR4 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10439290", "species_10465485" ], "products": [ "species_10474831" ], "modifiers": [], "additional_components": [ "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474836": { "compartment": "compartment_70101", "id": "reaction_10474836", "reactome": "R-DME-5654151", "name": "Activated FGFR4 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474831" ], "products": [ "species_10474833", "species_29370" ], "modifiers": [ [ "species_10474831", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_179838", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474848": { "compartment": "compartment_876", "id": "reaction_10474848", "reactome": "R-DME-5654169", "name": "p-4Y-PLCG1 dissociates from activated FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474833" ], "products": [ "species_10441915", "species_10465485" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10475119": { "compartment": "compartment_70101", "id": "reaction_10475119", "reactome": "R-DME-5654659", "name": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465487" ], "products": [ "species_10465489" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475132": { "compartment": "compartment_70101", "id": "reaction_10475132", "reactome": "R-DME-5654667", "name": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10475128" ], "products": [ "species_10475130" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475188": { "compartment": "compartment_70101", "id": "reaction_10475188", "reactome": "R-DME-5654717", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465491", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10438947": { "compartment": "compartment_70101", "id": "reaction_10438947", "reactome": "R-DME-177931", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431812", "species_10438839" ], "products": [ "species_10438945" ], "modifiers": [], "additional_components": [ "FBgn0020622", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475185": { "compartment": "compartment_70101", "id": "reaction_10475185", "reactome": "R-DME-5654714", "name": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10475182", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475103": { "compartment": "compartment_70101", "id": "reaction_10475103", "reactome": "R-DME-5654651", "name": "Activated FGFR4 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474997", "species_10465485" ], "products": [ "species_10475101" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475117": { "compartment": "compartment_876", "id": "reaction_10475117", "reactome": "R-DME-5654655", "name": "Activated FGFR4 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475112" ], "products": [ "species_29370", "species_10475114" ], "modifiers": [ [ "species_10475112", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10475126": { "compartment": "compartment_70101", "id": "reaction_10475126", "reactome": "R-DME-5654664", "name": "Activated FGFR4:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475110" ], "products": [ "species_10475121" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474949": { "compartment": "compartment_70101", "id": "reaction_10474949", "reactome": "R-DME-5654422", "name": "Activated FGFR4 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474873", "species_10465485" ], "products": [ "species_10474941" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475108": { "compartment": "compartment_876", "id": "reaction_10475108", "reactome": "R-DME-5654653", "name": "Activated FGFR4 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475101" ], "products": [ "species_10475105", "species_29370" ], "modifiers": [ [ "species_10475101", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475124": { "compartment": "compartment_70101", "id": "reaction_10475124", "reactome": "R-DME-5654663", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475121", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474946": { "compartment": "compartment_876", "id": "reaction_10474946", "reactome": "R-DME-5654418", "name": "Activated FGFR4 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474941" ], "products": [ "species_29370", "species_10465487" ], "modifiers": [ [ "species_10474941", "catalyst" ], [ "species_10474944", "inhibitor" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10493199": { "compartment": "compartment_70101", "id": "reaction_10493199", "reactome": "R-DME-8941613", "name": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475114", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10474959": { "compartment": "compartment_70101", "id": "reaction_10474959", "reactome": "R-DME-5654425", "name": "Activated FGFR4 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474909", "species_10465485" ], "products": [ "species_10474957" ], "modifiers": [], "additional_components": [ "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10474955": { "compartment": "compartment_876", "id": "reaction_10474955", "reactome": "R-DME-5654423", "name": "Activated FGFR4:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10474951" ], "products": [ "species_10474953" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474965": { "compartment": "compartment_70101", "id": "reaction_10474965", "reactome": "R-DME-5654428", "name": "Activated FGFR4 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474957" ], "products": [ "species_29370", "species_10474951" ], "modifiers": [ [ "species_10474957", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10474962": { "compartment": "compartment_70101", "id": "reaction_10474962", "reactome": "R-DME-5654426", "name": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474953", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475194": { "compartment": "compartment_70101", "id": "reaction_10475194", "reactome": "R-DME-5654734", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439154", "species_10475128" ], "products": [ "species_10475157" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10475162": { "compartment": "compartment_70101", "id": "reaction_10475162", "reactome": "R-DME-5654684", "name": "CBL ubiquitinates FRS2 and FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475157", "species_10426987" ], "products": [ "species_10475159" ], "modifiers": [ [ "species_10475157", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10458638": { "compartment": "compartment_70101", "id": "reaction_10458638", "reactome": "R-DME-1295634", "name": "SPRY2 is serine phosphorylated in response to MAPK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458630" ], "products": [ "species_10458603" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "O44783", "FBgn0014388", "P11346", "Raf", "O44783", "FBgn0014388", "P40417", "FBgn0003256" ] }, "reaction_10458605": { "compartment": "compartment_70101", "id": "reaction_10458605", "reactome": "R-DME-1295604", "name": "B-RAF dissociates from S111/S120 p-SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458603" ], "products": [ "species_10458599", "species_10458601" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "O44783", "FBgn0014388", "FBgn0014388" ] }, "reaction_10458620": { "compartment": "compartment_70101", "id": "reaction_10458620", "reactome": "R-DME-1295622", "name": "SPRY2 binds CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10458607" ], "products": [ "species_10455248", "species_10455223" ], "modifiers": [], "additional_components": [ "FBgn0020224", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10455243": { "compartment": "compartment_70101", "id": "reaction_10455243", "reactome": "R-DME-934559", "name": "SPRY2 is phosphorylated by phosphorylated MNK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10455225" ], "products": [ "species_29370", "species_10455231" ], "modifiers": [ [ "species_10455240", "catalyst" ] ], "additional_components": [ "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "FBgn0017581" ] }, "reaction_10458618": { "compartment": "compartment_70101", "id": "reaction_10458618", "reactome": "R-DME-1295621", "name": "CBL dissociates from ubiquitinated p-SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455250" ], "products": [ "species_10458616", "species_10439032" ], "modifiers": [], "additional_components": [ "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0020224" ] }, "reaction_10458614": { "compartment": "compartment_70101", "id": "reaction_10458614", "reactome": "R-DME-1295613", "name": "SPRY2 binds GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458607", "species_10431791" ], "products": [ "species_10458612" ], "modifiers": [], "additional_components": [ "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "FBgn0004638", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "Q08012", "FBgn0004638" ] }, "reaction_10455253": { "compartment": "compartment_70101", "id": "reaction_10455253", "reactome": "R-DME-934604", "name": "Phosphorylated SPRY2 is ubiquitinated by CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455248", "species_10426987" ], "products": [ "species_10455250" ], "modifiers": [ [ "species_10455248", "catalyst" ] ], "additional_components": [ "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224" ] }, "reaction_10458628": { "compartment": "compartment_70101", "id": "reaction_10458628", "reactome": "R-DME-1295632", "name": "PPA2A dephosphorylates SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458625" ], "products": [ "species_10458593", "species_29372" ], "modifiers": [ [ "species_10458625", "catalyst" ] ], "additional_components": [ "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10458595": { "compartment": "compartment_70101", "id": "reaction_10458595", "reactome": "R-DME-1295599", "name": "SPRY2 translocates to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458593" ], "products": [ "species_10455225" ], "modifiers": [], "additional_components": [ "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388" ] }, "reaction_10458609": { "compartment": "compartment_70101", "id": "reaction_10458609", "reactome": "R-DME-1295609", "name": "SRC phosphorylates SPRY2 on Y55 and Y227", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10455225" ], "products": [ "species_29370", "species_10458607" ], "modifiers": [ [ "species_10438975", "catalyst" ], [ "species_10455231", "inhibitor" ] ], "additional_components": [ "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "FBgn0262733", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10474993": { "compartment": "compartment_70101", "id": "reaction_10474993", "reactome": "R-DME-5654566", "name": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474941" ], "products": [ "species_10474944", "species_29370" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "P40417", "FBgn0003256" ] }, "reaction_10466163": { "compartment": "compartment_70101", "id": "reaction_10466163", "reactome": "R-DME-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466159" ], "products": [ "species_29370", "species_10466149" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "Q9V3A7", "FBgn0015391", "A1Z987", "FBgn0259876", "Q9VIP9", "FBgn0014127", "Q9VAJ1", "FBgn0039680", "Q7KK96", "FBgn0027783", "Q9VIP9", "FBgn0014127", "A1Z987", "FBgn0259876", "Q7KK96", "FBgn0027783", "Q9VAJ1", "FBgn0039680", "Q9V3A7", "FBgn0015391", "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10466161": { "compartment": "compartment_70101", "id": "reaction_10466161", "reactome": "R-DME-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10466149" ], "products": [ "species_29372", "species_10466159" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q9VIP9", "FBgn0014127", "A1Z987", "FBgn0259876", "Q7KK96", "FBgn0027783", "Q9VAJ1", "FBgn0039680", "Q9V3A7", "FBgn0015391", "Q9V3A7", "FBgn0015391", "A1Z987", "FBgn0259876", "Q9VIP9", "FBgn0014127", "Q9VAJ1", "FBgn0039680", "Q7KK96", "FBgn0027783" ] }, "reaction_10435527": { "compartment": "compartment_7660", "id": "reaction_10435527", "reactome": "R-DME-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435521", "species_113592" ], "products": [ "species_29370", "species_10435525" ], "modifiers": [ [ "species_10435513", "catalyst" ] ], "additional_components": [ "FBgn0021768", "FBgn0021768", "FBgn0003124" ] }, "reaction_10466047": { "compartment": "compartment_1598585", "id": "reaction_10466047", "reactome": "R-DME-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466044" ], "products": [ "species_29370", "species_10465943" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "A1Z8S6", "FBgn0260012", "Q9VCD8", "FBgn0040283", "O96689", "FBgn0260987", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "Q9VCD8", "FBgn0040283", "O96689", "FBgn0260987", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "Q9W517", "FBgn0004655", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10465958": { "compartment": "compartment_1598585", "id": "reaction_10465958", "reactome": "R-DME-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10465943" ], "products": [ "species_10465955", "species_29370" ], "modifiers": [ [ "species_10437677", "catalyst" ] ], "additional_components": [ "A1Z8S6", "FBgn0260012", "Q9VCD8", "FBgn0040283", "O96689", "FBgn0260987", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "Q9W517", "FBgn0004655", "O96689", "FBgn0260987", "Q9VCD8", "FBgn0040283", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "A1Z8S6", "FBgn0260012", "Q9W517", "FBgn0004655", "FBgn0003124" ] }, "reaction_10465193": { "compartment": "compartment_7660", "id": "reaction_10465193", "reactome": "R-DME-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10465179" ], "products": [ "species_113582", "species_10465182" ], "modifiers": [ [ "species_10465190", "catalyst" ] ], "additional_components": [ "FBgn0061515", "FBgn0061515", "FBgn0260399" ] }, "reaction_10465827": { "compartment": "compartment_7660", "id": "reaction_10465827", "reactome": "R-DME-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10465822" ], "products": [ "species_113582", "species_10465825" ], "modifiers": [ [ "species_10465190", "catalyst" ] ], "additional_components": [ "FBgn0061515", "FBgn0061515", "FBgn0260399" ] }, "reaction_10467211": { "compartment": "compartment_70101", "id": "reaction_10467211", "reactome": "R-DME-2990882", "name": "CDK1 phosphorylates NUP98", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432243", "species_113592" ], "products": [ "species_29370", "species_10467195" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10471162": { "compartment": "compartment_7660", "id": "reaction_10471162", "reactome": "R-DME-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10471135" ], "products": [ "species_113582", "species_10471160" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10470742": { "compartment": "compartment_7660", "id": "reaction_10470742", "reactome": "R-DME-5195402", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10469763" ], "products": [ "species_113582", "species_10469757" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "FBgn0263593", "FBgn0263593", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10469782": { "compartment": "compartment_13231", "id": "reaction_10469782", "reactome": "R-DME-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10469757" ], "products": [ "species_113550", "species_10469763" ], "modifiers": [ [ "species_10469779", "catalyst" ] ], "additional_components": [ "FBgn0263593", "FBgn0263593", "Q9VRG7", "FBgn0029067", "Q8T0B1", "FBgn0036090" ] }, "reaction_10471029": { "compartment": "compartment_13231", "id": "reaction_10471029", "reactome": "R-DME-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10469763", "catalyst" ] ], "additional_components": [ "FBgn0263593" ] }, "reaction_10445787": { "compartment": "compartment_7660", "id": "reaction_10445787", "reactome": "R-DME-380278", "name": "CCNB1:p-T160-CDK1 phosphorylates NUMA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10445775" ], "products": [ "species_113582", "species_10445785" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q9VGE4", "FBgn0037979", "Q8IR55", "FBgn0002873", "Q9VGE4", "FBgn0037979", "Q8IR55", "FBgn0002873", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10465453": { "compartment": "compartment_20699", "id": "reaction_10465453", "reactome": "R-DME-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465445", "species_113592" ], "products": [ "species_29370", "species_10465450" ], "modifiers": [ [ "species_10465445", "catalyst" ] ], "additional_components": [ "P52304", "FBgn0003124", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "O18332", "FBgn0285937", "species_29438", "Q9W289", "FBgn0034697", "P52304", "FBgn0003124", "Q9VW57", "FBgn0036919", "O18332", "FBgn0285937", "species_29438", "P52304", "FBgn0003124", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "O18332", "FBgn0285937", "species_29438" ] }, "reaction_10465713": { "compartment": "compartment_20699", "id": "reaction_10465713", "reactome": "R-DME-2422927", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465698", "species_113592" ], "products": [ "species_29370", "species_10465704" ], "modifiers": [ [ "species_10465710", "catalyst" ] ], "additional_components": [ "Q9VHE3", "FBgn0037688", "Q9VW57", "FBgn0036919", "O18333", "FBgn0014009", "species_29438", "Q9VHE3", "FBgn0037688", "Q9VW57", "FBgn0036919", "O18333", "FBgn0014009", "species_29438" ] }, "reaction_10465820": { "compartment": "compartment_7660", "id": "reaction_10465820", "reactome": "R-DME-2429719", "name": "MCPH1 sequesters condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450944", "species_10465223", "species_10465816" ], "products": [ "species_10465818" ], "modifiers": [], "additional_components": [ "FBgn0014879", "Q9VMQ4", "FBgn0051989", "Q9V3A7", "FBgn0015391", "Q8INL2", "FBgn0037831", "Q7KK96", "FBgn0027783", "FBgn0260959", "E1JH39", "FBgn0260959", "Q9VMQ4", "FBgn0051989", "Q9V3A7", "FBgn0015391", "Q8INL2", "FBgn0037831", "Q7KK96", "FBgn0027783", "P53997", "FBgn0014879" ] }, "reaction_10498393": { "compartment": "compartment_70101", "id": "reaction_10498393", "reactome": "R-DME-9667965", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467266", "species_10455162" ], "products": [ "species_10498391" ], "modifiers": [], "additional_components": [ "FBgn0028343", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q8MQX9", "FBgn0028343" ] }, "reaction_10497739": { "compartment": "compartment_13231", "id": "reaction_10497739", "reactome": "R-DME-9624798", "name": "LBR binds KPNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497735", "species_10443115" ], "products": [ "species_10497737" ], "modifiers": [], "additional_components": [ "FBgn0034657", "FBgn0262743", "O18388", "FBgn0262743", "Q8MLV1", "FBgn0034657" ] }, "reaction_10497741": { "compartment": "compartment_70101", "id": "reaction_10497741", "reactome": "R-DME-9624800", "name": "CDK1 phosphorylates LBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440460" ], "products": [ "species_29370", "species_10497735" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "FBgn0034657", "FBgn0034657", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10467280": { "compartment": "compartment_70101", "id": "reaction_10467280", "reactome": "R-DME-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467266", "species_10467276" ], "products": [ "species_10467278" ], "modifiers": [], "additional_components": [ "FBgn0028343", "Q7KRY6", "FBgn0027889", "Q7KMI3", "FBgn0027504", "Q7KRY6", "FBgn0027889", "Q7KMI3", "FBgn0027504", "Q8MQX9", "FBgn0028343" ] }, "reaction_10498422": { "compartment": "compartment_70101", "id": "reaction_10498422", "reactome": "R-DME-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498413", "species_10498418" ], "products": [ "species_10498420" ], "modifiers": [], "additional_components": [ "Q8I0P1", "FBgn0039141", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "FBgn0283469", "Q9Y162", "FBgn0283469", "Q8I0P1", "FBgn0039141", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10498424": { "compartment": "compartment_13231", "id": "reaction_10498424", "reactome": "R-DME-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498409", "species_10498405" ], "products": [ "species_10498411" ], "modifiers": [], "additional_components": [ "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "FBgn0261983", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10498426": { "compartment": "compartment_70101", "id": "reaction_10498426", "reactome": "R-DME-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498411", "species_10498400" ], "products": [ "species_10498413" ], "modifiers": [], "additional_components": [ "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "FBgn0039141", "Q8I0P1", "FBgn0039141", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10497749": { "compartment": "compartment_1598585", "id": "reaction_10497749", "reactome": "R-DME-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10442325" ], "products": [ "species_10472625", "species_29420" ], "modifiers": [ [ "species_10497746", "catalyst" ] ], "additional_components": [ "species_29420", "Q9VZ23", "FBgn0020255", "Q9VZ23", "FBgn0020255", "species_29438", "FBgn0002638" ] }, "reaction_10497641": { "compartment": "compartment_70101", "id": "reaction_10497641", "reactome": "R-DME-9618378", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497596", "species_10432171" ], "products": [ "species_10497639" ], "modifiers": [], "additional_components": [ "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VWE6", "FBgn0031052", "FBgn0010660", "Q9W1X4", "FBgn0010660", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VWE6", "FBgn0031052" ] }, "reaction_10497753": { "compartment": "compartment_70101", "id": "reaction_10497753", "reactome": "R-DME-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472625", "species_9624879" ], "products": [ "species_10497751" ], "modifiers": [], "additional_components": [ "Q9VZ23", "FBgn0020255", "species_29438", "Q9VZ23", "FBgn0020255", "species_29438" ] }, "reaction_10497598": { "compartment": "compartment_70101", "id": "reaction_10497598", "reactome": "R-DME-9615901", "name": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10497594", "species_10432219" ], "products": [ "species_10497596" ], "modifiers": [], "additional_components": [ "FBgn0031052", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VWE6", "FBgn0031052" ] }, "reaction_10436113": { "compartment": "compartment_7660", "id": "reaction_10436113", "reactome": "R-DME-163010", "name": "Down Regulation of Emi1 through Phosphorylation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10436108" ], "products": [ "species_113582", "species_10436111" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0017551", "FBgn0017551", "FBgn0003124" ] }, "reaction_10466038": { "compartment": "compartment_7660", "id": "reaction_10466038", "reactome": "R-DME-2468040", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466008", "species_10466010", "species_10466014" ], "products": [ "species_10466016" ], "modifiers": [], "additional_components": [ "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "FBgn0260012", "FBgn0004655", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616" ] }, "reaction_10466067": { "compartment": "compartment_1598585", "id": "reaction_10466067", "reactome": "R-DME-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466016", "species_2537690", "species_10466059" ], "products": [ "species_10466065" ], "modifiers": [], "additional_components": [ "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q7PLI2", "FBgn0026401", "Q9VFC0", "FBgn0038300", "Q7PLI2", "FBgn0026401", "Q9VFC0", "FBgn0038300", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616" ] }, "reaction_10435497": { "compartment": "compartment_7660", "id": "reaction_10435497", "reactome": "R-DME-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10435484" ], "products": [ "species_113582", "species_10435488" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0011692", "FBgn0011692", "FBgn0003124" ] }, "reaction_10435542": { "compartment": "compartment_7660", "id": "reaction_10435542", "reactome": "R-DME-156723", "name": "Regulation of KIF20A (MKL2) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10435537" ], "products": [ "species_113582", "species_10435540" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0003545", "FBgn0003545", "FBgn0003124" ] }, "reaction_10448542": { "compartment": "compartment_70101", "id": "reaction_10448542", "reactome": "R-DME-428231", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428256" ], "products": [ "species_428193", "species_428198" ], "modifiers": [ [ "species_10448539", "catalyst" ] ], "additional_components": [ "FBgn0045064" ] }, "reaction_10478169": { "compartment": "compartment_12045", "id": "reaction_10478169", "reactome": "R-DME-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10478166", "catalyst" ] ], "additional_components": [ "FBgn0050502" ] }, "reaction_10448537": { "compartment": "compartment_70101", "id": "reaction_10448537", "reactome": "R-DME-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428163" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10448534", "catalyst" ] ], "additional_components": [ "Q9VYY8", "FBgn0030300", "Q9VZW0", "FBgn0052484" ] }, "reaction_10448919": { "compartment": "compartment_12045", "id": "reaction_10448919", "reactome": "R-DME-429699", "name": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448902", "species_428256" ], "products": [ "species_10448900" ], "modifiers": [], "additional_components": [ "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "species_429807", "Q9Y128", "FBgn0027569" ] }, "reaction_10498667": { "compartment": "compartment_70101", "id": "reaction_10498667", "reactome": "R-DME-9695890", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_419305" ], "modifiers": [ [ "species_10498664", "catalyst" ] ], "additional_components": [ "FBgn0086676" ] }, "reaction_10448914": { "compartment": "compartment_70101", "id": "reaction_10448914", "reactome": "R-DME-429694", "name": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448902" ], "products": [ "species_10448912", "species_10448891" ], "modifiers": [], "additional_components": [ "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515" ] }, "reaction_10448498": { "compartment": "compartment_70101", "id": "reaction_10448498", "reactome": "R-DME-428127", "name": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_9695889" ], "products": [ "species_113528", "species_76194", "species_428182" ], "modifiers": [ [ "species_10448490", "catalyst" ], [ "species_10448496", "inhibitor" ] ], "additional_components": [ "Q6NR46", "FBgn0086532", "Q9V3F2", "FBgn0002524", "A8DYH6", "FBgn0085223", "FBgn0037110" ] }, "reaction_10448464": { "compartment": "compartment_70101", "id": "reaction_10448464", "reactome": "R-DME-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10448461", "catalyst" ] ], "additional_components": [ "FBgn0039304" ] }, "reaction_10448656": { "compartment": "compartment_984", "id": "reaction_10448656", "reactome": "R-DME-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10448653", "catalyst" ] ], "additional_components": [ "FBgn0016078" ] }, "reaction_10498672": { "compartment": "compartment_70101", "id": "reaction_10498672", "reactome": "R-DME-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10448532", "catalyst" ], [ "species_10498670", "inhibitor" ] ], "additional_components": [ "Q9VYY8", "FBgn0030300", "Q9VZW0", "FBgn0052484", "Q9VYY8", "FBgn0030300", "Q9VZW0", "FBgn0052484" ] }, "reaction_10448909": { "compartment": "compartment_12045", "id": "reaction_10448909", "reactome": "R-DME-429683", "name": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448900" ], "products": [ "species_10448902", "species_428270" ], "modifiers": [ [ "species_10448907", "catalyst" ] ], "additional_components": [ "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "species_429807", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "FBgn0020626" ] }, "reaction_10448556": { "compartment": "compartment_70101", "id": "reaction_10448556", "reactome": "R-DME-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10446693", "catalyst" ] ], "additional_components": [ "FBgn0030300" ] }, "reaction_10448523": { "compartment": "compartment_20699", "id": "reaction_10448523", "reactome": "R-DME-428205", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428270" ], "products": [ "species_428248", "species_8934421" ], "modifiers": [ [ "species_10448520", "catalyst" ] ], "additional_components": [ "FBgn0045064" ] }, "reaction_10495317": { "compartment": "compartment_12045", "id": "reaction_10495317", "reactome": "R-DME-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10495314", "catalyst" ] ], "additional_components": [ "FBgn0052380" ] }, "reaction_10448553": { "compartment": "compartment_70101", "id": "reaction_10448553", "reactome": "R-DME-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428126", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9025544" ], "modifiers": [ [ "species_10448547", "catalyst" ] ], "additional_components": [ "FBgn0001941" ] }, "reaction_10448648": { "compartment": "compartment_70101", "id": "reaction_10448648", "reactome": "R-DME-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10448643", "catalyst" ] ], "additional_components": [ "FBgn0010591" ] }, "reaction_10448711": { "compartment": "compartment_70101", "id": "reaction_10448711", "reactome": "R-DME-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10448708", "catalyst" ] ], "additional_components": [ "Q9V576", "FBgn0016078", "Q9VNT8", "FBgn0037341", "Q9VNU1", "FBgn0037341", "Q9VNU0", "FBgn0037165", "Q7KGH1", "FBgn0041087", "Q9VNT9", "FBgn0037341", "Q9VNU2", "FBgn0037163" ] }, "reaction_10448550": { "compartment": "compartment_70101", "id": "reaction_10448550", "reactome": "R-DME-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10448547", "catalyst" ] ], "additional_components": [ "species_29362", "species_29364", "species_427523", "species_29366", "FBgn0001941" ] }, "reaction_10448646": { "compartment": "compartment_70101", "id": "reaction_10448646", "reactome": "R-DME-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428671", "species_428686" ], "modifiers": [ [ "species_10448643", "catalyst" ] ], "additional_components": [ "FBgn0010591" ] }, "reaction_10448932": { "compartment": "compartment_70101", "id": "reaction_10448932", "reactome": "R-DME-429732", "name": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448923", "species_10448891" ], "products": [ "species_10448927" ], "modifiers": [], "additional_components": [ "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515" ] }, "reaction_10448515": { "compartment": "compartment_70101", "id": "reaction_10448515", "reactome": "R-DME-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10448504", "catalyst" ] ], "additional_components": [ "FBgn0040918" ] }, "reaction_10448930": { "compartment": "compartment_70101", "id": "reaction_10448930", "reactome": "R-DME-429730", "name": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10448927" ], "products": [ "species_29372", "species_10448902" ], "modifiers": [ [ "species_10448927", "catalyst" ] ], "additional_components": [ "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515" ] }, "reaction_10474424": { "compartment": "compartment_261122", "id": "reaction_10474424", "reactome": "R-DME-5633040", "name": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474422" ], "products": [ "species_10474420", "species_10474409", "species_10474399" ], "modifiers": [], "additional_components": [ "P32865", "FBgn0260798", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "P91682", "phospho-smo", "P91682", "phospho-smo", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "FBgn0260798" ] }, "reaction_10497842": { "compartment": "compartment_876", "id": "reaction_10497842", "reactome": "R-DME-9632906", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438980", "species_10497827" ], "products": [ "species_10497840" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29420", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "P08646", "RAS85D", "species_29420" ] }, "reaction_10497830": { "compartment": "compartment_876", "id": "reaction_10497830", "reactome": "R-DME-9632858", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497822", "species_113592" ], "products": [ "species_29370", "species_10497827" ], "modifiers": [ [ "species_10497822", "catalyst" ] ], "additional_components": [ "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10497846": { "compartment": "compartment_7660", "id": "reaction_10497846", "reactome": "R-DME-9632910", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458634" ], "products": [ "species_10440931" ], "modifiers": [ [ "species_10497844", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "species_29438", "P08646", "RAS85D" ] }, "reaction_10497849": { "compartment": "compartment_876", "id": "reaction_10497849", "reactome": "R-DME-9632918", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497840" ], "products": [ "species_10497844" ], "modifiers": [], "additional_components": [ "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "P08646", "RAS85D", "species_29420", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "species_29438", "P08646", "RAS85D" ] }, "reaction_10449671": { "compartment": "compartment_172574", "id": "reaction_10449671", "reactome": "R-DME-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_445832", "species_1470067" ], "modifiers": [ [ "species_10449668", "catalyst" ] ], "additional_components": [ "species_1562550", "species_111793", "species_266099", "species_1562550", "species_266099", "species_111793", "FBgn0011672" ] }, "reaction_10449893": { "compartment": "compartment_7660", "id": "reaction_10449893", "reactome": "R-DME-442724", "name": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10449875", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0262866" ] }, "reaction_10497038": { "compartment": "compartment_7660", "id": "reaction_10497038", "reactome": "R-DME-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497030" ], "products": [ "species_10449875" ], "modifiers": [], "additional_components": [ "FBgn0262866", "FBgn0262866" ] }, "reaction_10450823": { "compartment": "compartment_5460", "id": "reaction_10450823", "reactome": "R-DME-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10450820", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "O77460", "FBgn0016687" ] }, "reaction_390087": { "compartment": "compartment_70101", "id": "reaction_390087", "reactome": "R-DME-390087", "name": "WTS binds to SAV", "reversible": "false", "notes": "The serine/threonine kinase, Warts (WTS), binds to the WW domain of the scaffolding protein Salvador (SAV). Hippo (HPO) kinase homodimer and WTS bind to different portions of SAV and the three proteins form a ternary complex.", "reactants": [ "species_451812", "species_390037" ], "products": [ "species_451836" ], "modifiers": [], "additional_components": [ "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO" ] }, "reaction_390145": { "compartment": "compartment_70101", "id": "reaction_390145", "reactome": "R-DME-390145", "name": "Phosphorylated HPO dimer phosphorylates SAV", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase homodimer phosphorylates the scaffolding Salvador (SAV) at unknown residues.", "reactants": [ "species_113592", "species_451829" ], "products": [ "species_29370", "species_451860" ], "modifiers": [ [ "species_451829", "catalyst" ] ], "additional_components": [ "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VCR6", "SAV", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q95RA8", "MATS" ] }, "reaction_390112": { "compartment": "compartment_70101", "id": "reaction_390112", "reactome": "R-DME-390112", "name": "Phosphorylated HPO dimer phosphorylates WTS", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase homodimer phosphorylates Warts (WTS) kinase at unknown residues.", "reactants": [ "species_113592", "species_451860" ], "products": [ "species_29370", "species_390172" ], "modifiers": [ [ "species_451860", "catalyst" ] ], "additional_components": [ "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VCR6", "SAV" ] }, "reaction_390035": { "compartment": "compartment_70101", "id": "reaction_390035", "reactome": "R-DME-390035", "name": "HPO dimer autophosphorylates", "reversible": "false", "notes": "The Hippo (HPO) serine/threonine kinase homodimer autophosphorylates on unknown residues and is activated. The scaffolding protein Salvador (SAV) appears to modestly increase the ability of HPO to autophosphorylate.", "reactants": [ "species_451805", "species_113592" ], "products": [ "species_29370", "species_451829" ], "modifiers": [ [ "species_451805", "catalyst" ] ], "additional_components": [ "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q8T0S6", "HPO", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q8T0S6", "HPO" ] }, "reaction_390124": { "compartment": "compartment_70101", "id": "reaction_390124", "reactome": "R-DME-390124", "name": "MATS binds to HPO dimer", "reversible": "false", "notes": "Mps one binder kinase activator-like 1 aka Mob as tumor suppressor protein 1 (MATS) associates with Hippo (HPO) kinase to form a complex.", "reactants": [ "species_390158", "species_451836" ], "products": [ "species_451805" ], "modifiers": [], "additional_components": [ "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q8T0S6", "HPO" ] }, "reaction_390025": { "compartment": "compartment_70101", "id": "reaction_390025", "reactome": "R-DME-390025", "name": "Phosphorylated WTS autophosphorylates", "reversible": "false", "notes": "Phosphorylated Warts (WTS) serine/threonine kinase autophosphorylates at unknown residues. WTS linase is now fully activated.", "reactants": [ "species_113592", "species_390134" ], "products": [ "species_29370", "species_390068" ], "modifiers": [ [ "species_390134", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390011": { "compartment": "compartment_70101", "id": "reaction_390011", "reactome": "R-DME-390011", "name": "HPO dimer binds to SAV", "reversible": "false", "notes": "Hippo (HPO) kinase homodimer associates with the scaffolding protein Salvador (SAV). The C-terminal SARAH (Salvador/Rassf/Hippo) domains of HPO homodimer bind to the N-terminal SARAH domian of SAV.", "reactants": [ "species_390185", "species_390014" ], "products": [ "species_451812" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q8T0S6", "HPO" ] }, "reaction_390154": { "compartment": "compartment_70101", "id": "reaction_390154", "reactome": "R-DME-390154", "name": "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS", "reversible": "false", "notes": "Mps one binder kinase activator-like 1 aka Mob as tumor suppressor protein 1 (MATS) is phosphorylated at unknown residues by the activated Hippo (HPO) serine/threonine kinase homodimer. The phosphorylation of MATS by HPO promotes its binding to Warts (WTS) kinase. MATS helps to activate WTS by relieving an autoinhibitory interaction between the N-terminal region and the C-terminal kinase region of WTS. It appears that MATS cannot simultaneously associate with HPO kinase homodimer and WTS in the same protein complex, so MATS dissociates from HPO homodimer and binds to phosphorylated WTS.", "reactants": [ "species_113592", "species_390172" ], "products": [ "species_29370", "species_390134" ], "modifiers": [ [ "species_390172", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_10476607": { "compartment": "compartment_70101", "id": "reaction_10476607", "reactome": "R-DME-5686073", "name": "GRB2-1:SOS1 binds p-3Y-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10476601" ], "products": [ "species_10476605" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10440940": { "compartment": "compartment_7660", "id": "reaction_10440940", "reactome": "R-DME-198756", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10440887" ], "products": [ "species_113582", "species_10440893" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "FBgn0020412", "FBgn0020412", "P40417", "FBgn0003256" ] }, "reaction_10440938": { "compartment": "compartment_7660", "id": "reaction_10440938", "reactome": "R-DME-198746", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10440901" ], "products": [ "species_113582", "species_10440913" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "FBgn0262866", "FBgn0262866", "P40417", "FBgn0003256" ] }, "reaction_10442249": { "compartment": "compartment_7660", "id": "reaction_10442249", "reactome": "R-DME-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10440935" ], "products": [ "species_113550", "species_10441236" ], "modifiers": [ [ "species_10442232", "catalyst" ], [ "species_10442247", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "X2JEB8", "FBgn0030976", "Q9VVW5", "FBgn0036844", "X2JEB8", "FBgn0030976", "Q7KMI3", "FBgn0027504", "Q7KRY6", "FBgn0027889" ] }, "reaction_10441253": { "compartment": "compartment_7660", "id": "reaction_10441253", "reactome": "R-DME-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10440935" ], "products": [ "species_113550", "species_10441236" ], "modifiers": [ [ "species_10441250", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q8IN89", "FBgn0042693" ] }, "reaction_10440896": { "compartment": "compartment_7660", "id": "reaction_10440896", "reactome": "R-DME-198669", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10440887" ], "products": [ "species_113582", "species_10440893" ], "modifiers": [ [ "species_10437359", "catalyst" ] ], "additional_components": [ "FBgn0020412", "FBgn0020412", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765" ] }, "reaction_10441211": { "compartment": "compartment_7660", "id": "reaction_10441211", "reactome": "R-DME-199895", "name": "RSK1/2/3 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10440913", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0262866" ] }, "reaction_10441226": { "compartment": "compartment_7660", "id": "reaction_10441226", "reactome": "R-DME-199935", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10440893", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0020412" ] }, "reaction_10441224": { "compartment": "compartment_7660", "id": "reaction_10441224", "reactome": "R-DME-199917", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10441221", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0013987" ] }, "reaction_10441219": { "compartment": "compartment_7660", "id": "reaction_10441219", "reactome": "R-DME-199910", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441213" ], "products": [ "species_113582", "species_10441216" ], "modifiers": [ [ "species_10440893", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0020412" ] }, "reaction_10440286": { "compartment": "compartment_70101", "id": "reaction_10440286", "reactome": "R-DME-193401", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10440156": { "compartment": "compartment_17951", "id": "reaction_10440156", "reactome": "R-DME-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_113575", "species_192342" ], "modifiers": [ [ "species_10440153", "catalyst" ] ], "additional_components": [ "species_113596", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628" ] }, "reaction_10440088": { "compartment": "compartment_70101", "id": "reaction_10440088", "reactome": "R-DME-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_192136", "species_29364" ], "products": [ "species_191980", "species_29366" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440119": { "compartment": "compartment_70101", "id": "reaction_10440119", "reactome": "R-DME-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440117": { "compartment": "compartment_70101", "id": "reaction_10440117", "reactome": "R-DME-192137", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10440115": { "compartment": "compartment_70101", "id": "reaction_10440115", "reactome": "R-DME-192097", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192114" ], "products": [ "species_70106", "species_192136", "species_73473" ], "modifiers": [ [ "species_10440112", "catalyst" ] ], "additional_components": [ "FBgn0036698" ] }, "reaction_10440275": { "compartment": "compartment_17951", "id": "reaction_10440275", "reactome": "R-DME-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_193442" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10440153", "catalyst" ] ], "additional_components": [ "species_113596", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628" ] }, "reaction_10440107": { "compartment": "compartment_70101", "id": "reaction_10440107", "reactome": "R-DME-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440299": { "compartment": "compartment_17951", "id": "reaction_10440299", "reactome": "R-DME-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440105": { "compartment": "compartment_17951", "id": "reaction_10440105", "reactome": "R-DME-192056", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192308" ], "products": [ "species_192316" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440297": { "compartment": "compartment_17951", "id": "reaction_10440297", "reactome": "R-DME-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440295": { "compartment": "compartment_17951", "id": "reaction_10440295", "reactome": "R-DME-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440292": { "compartment": "compartment_17951", "id": "reaction_10440292", "reactome": "R-DME-193452", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193429" ], "products": [ "species_193442" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440290": { "compartment": "compartment_70101", "id": "reaction_10440290", "reactome": "R-DME-193424", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193505" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10440097": { "compartment": "compartment_70101", "id": "reaction_10440097", "reactome": "R-DME-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440129": { "compartment": "compartment_17951", "id": "reaction_10440129", "reactome": "R-DME-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192342" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440288": { "compartment": "compartment_70101", "id": "reaction_10440288", "reactome": "R-DME-193407", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_193505", "species_76194" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10447126": { "compartment": "compartment_70101", "id": "reaction_10447126", "reactome": "R-DME-399944", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447104", "species_113592", "species_10447082" ], "products": [ "species_10447123", "species_29370" ], "modifiers": [ [ "species_10447104", "catalyst" ] ], "additional_components": [ "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259" ] }, "reaction_10447158": { "compartment": "compartment_70101", "id": "reaction_10447158", "reactome": "R-DME-399951", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447123", "species_113592" ], "products": [ "species_10447155", "species_29370" ], "modifiers": [ [ "species_10440540", "catalyst" ] ], "additional_components": [ "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P83101", "FBgn0046332", "P18431", "sgg" ] }, "reaction_10447140": { "compartment": "compartment_70101", "id": "reaction_10447140", "reactome": "R-DME-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447082", "species_10447002" ], "products": [ "species_10447137", "species_29370" ], "modifiers": [ [ "species_10442644", "catalyst" ] ], "additional_components": [ "Q8IPQ2", "FBgn0023023", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "Q8IPQ2", "FBgn0023023", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "FBgn0000723" ] }, "reaction_10447319": { "compartment": "compartment_70101", "id": "reaction_10447319", "reactome": "R-DME-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447312", "species_10442527" ], "products": [ "species_10447314" ], "modifiers": [], "additional_components": [ "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731", "FBgn0023172", "A1ZAN6", "FBgn0023172", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731" ] }, "reaction_10444630": { "compartment": "compartment_70101", "id": "reaction_10444630", "reactome": "R-DME-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10444615", "species_10444599" ], "products": [ "species_10444627", "species_29370" ], "modifiers": [ [ "species_10444615", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740" ] }, "reaction_10447317": { "compartment": "compartment_70101", "id": "reaction_10447317", "reactome": "R-DME-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447308" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10447314", "catalyst" ] ], "additional_components": [ "species_29420", "P48148", "Rho1", "P48148", "Rho1", "species_29438", "A1ZAN6", "FBgn0023172", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731" ] }, "reaction_10447651": { "compartment": "compartment_70101", "id": "reaction_10447651", "reactome": "R-DME-419049", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604", "species_10434906" ], "products": [ "species_10447647" ], "modifiers": [ [ "species_10447649", "inhibitor" ] ], "additional_components": [ "FBgn0026181", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181", "Q9VXE3", "FBgn0026181" ] }, "reaction_10498524": { "compartment": "compartment_70101", "id": "reaction_10498524", "reactome": "R-DME-9680443", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9686558", "species_10441604" ], "products": [ "species_10447649" ], "modifiers": [], "additional_components": [ "FBgn0026181", "Q9VXE3", "FBgn0026181" ] }, "reaction_10447670": { "compartment": "compartment_70101", "id": "reaction_10447670", "reactome": "R-DME-419645", "name": "Dimerization of LIMK1 by Hsp90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441846", "species_10447166" ], "products": [ "species_10447660" ], "modifiers": [], "additional_components": [ "FBgn0001233", "FBgn0283712", "Q8IR79", "FBgn0283712", "P02828", "FBgn0001233" ] }, "reaction_10447668": { "compartment": "compartment_70101", "id": "reaction_10447668", "reactome": "R-DME-419644", "name": "Transphosphorylation of pLIMK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447660" ], "products": [ "species_10447665", "species_29370", "species_10441846" ], "modifiers": [ [ "species_10447660", "catalyst" ] ], "additional_components": [ "Q8IR79", "FBgn0283712", "P02828", "FBgn0001233", "Q8IR79", "FBgn0283712", "FBgn0001233", "Q8IR79", "FBgn0283712", "P02828", "FBgn0001233" ] }, "reaction_10447074": { "compartment": "compartment_70101", "id": "reaction_10447074", "reactome": "R-DME-399939", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447006" ], "products": [ "species_29370", "species_10447071" ], "modifiers": [ [ "species_10447006", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10447169": { "compartment": "compartment_70101", "id": "reaction_10447169", "reactome": "R-DME-399952", "name": "Phosphorylation of LIMK-1 by PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447163" ], "products": [ "species_29370", "species_10447166" ], "modifiers": [ [ "species_10447071", "catalyst" ] ], "additional_components": [ "FBgn0283712", "FBgn0283712", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10447008": { "compartment": "compartment_70101", "id": "reaction_10447008", "reactome": "R-DME-399930", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446523", "species_10447004" ], "products": [ "species_10447006", "species_10446511" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698" ] }, "reaction_10447047": { "compartment": "compartment_876", "id": "reaction_10447047", "reactome": "R-DME-399933", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447041", "species_10446972" ], "products": [ "species_10447045", "species_10447037" ], "modifiers": [], "additional_components": [ "A8JQT5", "FBgn0265082", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P00528", "FBgn0262733", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P00528", "FBgn0262733", "FBgn0265082" ] }, "reaction_10447058": { "compartment": "compartment_70101", "id": "reaction_10447058", "reactome": "R-DME-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447037", "species_10447054" ], "products": [ "species_10447056", "species_10444276" ], "modifiers": [], "additional_components": [ "FBgn0265082", "Q0E8Y1", "FBgn0034789", "Q9VSL8", "FBgn0260442", "A8JQT5", "FBgn0265082", "Q0E8Y1", "FBgn0034789", "FBgn0260442" ] }, "reaction_10449663": { "compartment": "compartment_876", "id": "reaction_10449663", "reactome": "R-DME-434989", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449651", "species_10449659" ], "products": [ "species_10449661" ], "modifiers": [], "additional_components": [ "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740" ] }, "reaction_10447402": { "compartment": "compartment_984", "id": "reaction_10447402", "reactome": "R-DME-416683", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447392", "species_10447398" ], "products": [ "species_10447400" ], "modifiers": [], "additional_components": [ "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259" ] }, "reaction_10447414": { "compartment": "compartment_876", "id": "reaction_10447414", "reactome": "R-DME-416690", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447410", "species_10447398" ], "products": [ "species_10447412" ], "modifiers": [], "additional_components": [ "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059" ] }, "reaction_10447429": { "compartment": "compartment_876", "id": "reaction_10447429", "reactome": "R-DME-416698", "name": "SEMA5A binds to PLXNB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447425", "species_10447419" ], "products": [ "species_10447427" ], "modifiers": [], "additional_components": [ "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "FBgn0284221", "Q9VTT0", "FBgn0284221", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741" ] }, "reaction_10446800": { "compartment": "compartment_70101", "id": "reaction_10446800", "reactome": "R-DME-392054", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10446797", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "P00528", "FBgn0262733", "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617" ] }, "reaction_10444970": { "compartment": "compartment_984", "id": "reaction_10444970", "reactome": "R-DME-375160", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114570", "species_10444966" ], "products": [ "species_10444968" ], "modifiers": [], "additional_components": [ "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617", "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617", "species_113592" ] }, "reaction_10445181": { "compartment": "compartment_876", "id": "reaction_10445181", "reactome": "R-DME-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445177" ], "products": [ "species_10445179" ], "modifiers": [], "additional_components": [ "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046" ] }, "reaction_10445193": { "compartment": "compartment_70101", "id": "reaction_10445193", "reactome": "R-DME-376123", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445189", "species_10445167" ], "products": [ "species_10445191" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10451543": { "compartment": "compartment_70101", "id": "reaction_10451543", "reactome": "R-DME-451347", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_10437429", "species_29370" ], "modifiers": [ [ "species_10445191", "catalyst" ] ], "additional_components": [ "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10451574": { "compartment": "compartment_70101", "id": "reaction_10451574", "reactome": "R-DME-451366", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451571", "species_113592" ], "products": [ "species_29370", "species_10439434" ], "modifiers": [ [ "species_10445191", "catalyst" ] ], "additional_components": [ "species_29926", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "species_29926", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10444747": { "compartment": "compartment_70101", "id": "reaction_10444747", "reactome": "R-DME-374662", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444743", "species_179856" ], "products": [ "species_10444745" ], "modifiers": [], "additional_components": [ "FBgn0011661", "species_179856", "P46150", "FBgn0011661" ] }, "reaction_10444759": { "compartment": "compartment_70101", "id": "reaction_10444759", "reactome": "R-DME-374664", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10444745" ], "products": [ "species_10444752", "species_29370" ], "modifiers": [ [ "species_10441896", "catalyst" ] ], "additional_components": [ "species_179856", "P46150", "FBgn0011661", "P46150", "FBgn0011661", "species_179856", "FBgn0259680" ] }, "reaction_10444447": { "compartment": "compartment_876", "id": "reaction_10444447", "reactome": "R-DME-373707", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444421", "species_10444443" ], "products": [ "species_10444445" ], "modifiers": [], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444795": { "compartment": "compartment_70101", "id": "reaction_10444795", "reactome": "R-DME-374701", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10444792" ], "products": [ "species_29370", "species_10444508" ], "modifiers": [ [ "species_10444792", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444449": { "compartment": "compartment_984", "id": "reaction_10444449", "reactome": "R-DME-373711", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444421", "species_10444441" ], "products": [ "species_10444443" ], "modifiers": [], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "FBgn0015773", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444512": { "compartment": "compartment_70101", "id": "reaction_10444512", "reactome": "R-DME-373716", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444486", "species_10444508" ], "products": [ "species_10444510" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "Q9VPU1", "dock" ] }, "reaction_10453702": { "compartment": "compartment_876", "id": "reaction_10453702", "reactome": "R-DME-593685", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10453698", "species_10453691" ], "products": [ "species_10453700" ], "modifiers": [], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q95TU8", "FBgn0034013", "FBgn0261800", "P11046", "FBgn0261800", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q95TU8", "FBgn0034013" ] }, "reaction_10444756": { "compartment": "compartment_876", "id": "reaction_10444756", "reactome": "R-DME-374663", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444752", "species_10444421" ], "products": [ "species_10444754" ], "modifiers": [], "additional_components": [ "P46150", "FBgn0011661", "species_179856", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "P46150", "FBgn0011661", "species_179856" ] }, "reaction_10444786": { "compartment": "compartment_70101", "id": "reaction_10444786", "reactome": "R-DME-374667", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444443", "species_10444782" ], "products": [ "species_10444784" ], "modifiers": [], "additional_components": [ "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444768": { "compartment": "compartment_70101", "id": "reaction_10444768", "reactome": "R-DME-374665", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444443", "species_10444764" ], "products": [ "species_10444766" ], "modifiers": [], "additional_components": [ "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "FBgn0003410", "P21461", "FBgn0003410", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10496097": { "compartment": "compartment_984", "id": "reaction_10496097", "reactome": "R-DME-9010815", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496093", "species_2299699" ], "products": [ "species_10496095" ], "modifiers": [], "additional_components": [ "Q9VUN0", "FBgn0036494", "P24014", "sli", "species_2299699", "Q9VUN0", "FBgn0036494", "P24014", "sli" ] }, "reaction_10448744": { "compartment": "compartment_70101", "id": "reaction_10448744", "reactome": "R-DME-428888", "name": "Phosphorylation of ROBO1 by ABL kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445201", "species_113592" ], "products": [ "species_29370", "species_10448741" ], "modifiers": [ [ "species_10445201", "catalyst" ] ], "additional_components": [ "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9W213", "FBgn0005631", "M9PC46", "FBgn0002543", "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631" ] }, "reaction_10445203": { "compartment": "compartment_70101", "id": "reaction_10445203", "reactome": "R-DME-376141", "name": "Interaction of ABL with ROBO1:SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442417", "species_10445197" ], "products": [ "species_10445201" ], "modifiers": [], "additional_components": [ "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631" ] }, "reaction_10448598": { "compartment": "compartment_876", "id": "reaction_10448598", "reactome": "R-DME-428518", "name": "Glypican-1 (GPC1) binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448594", "species_10448587" ], "products": [ "species_10448596" ], "modifiers": [], "additional_components": [ "Q9VUG1", "FBgn0041604", "CHEBI:17421", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9VUG1", "FBgn0041604", "CHEBI:17421" ] }, "reaction_10496540": { "compartment": "compartment_984", "id": "reaction_10496540", "reactome": "R-DME-9014812", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496536", "species_2299699" ], "products": [ "species_10496538" ], "modifiers": [], "additional_components": [ "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "species_2299699", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog" ] }, "reaction_10442419": { "compartment": "compartment_876", "id": "reaction_10442419", "reactome": "R-DME-204364", "name": "ROBO1 binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442404", "species_10442415" ], "products": [ "species_10442417" ], "modifiers": [], "additional_components": [ "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631" ] }, "reaction_10448585": { "compartment": "compartment_876", "id": "reaction_10448585", "reactome": "R-DME-428510", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448581", "species_10448573" ], "products": [ "species_10448583" ], "modifiers": [], "additional_components": [ "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog" ] }, "reaction_10469295": { "compartment": "compartment_876", "id": "reaction_10469295", "reactome": "R-DME-3928591", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469291", "species_10469293" ], "products": [ "species_10469226" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469436": { "compartment": "compartment_70101", "id": "reaction_10469436", "reactome": "R-DME-3928641", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469389", "species_10446511" ], "products": [ "species_10469391" ], "modifiers": [], "additional_components": [ "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469434": { "compartment": "compartment_70101", "id": "reaction_10469434", "reactome": "R-DME-3928640", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10450286" ], "products": [ "species_10450386", "species_29370" ], "modifiers": [ [ "species_10469397", "catalyst" ] ], "additional_components": [ "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10469641": { "compartment": "compartment_70101", "id": "reaction_10469641", "reactome": "R-DME-4093329", "name": "EFNBs bind SDCBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469222", "species_10444571" ], "products": [ "species_10469639" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "FBgn0051342", "A8JQY9", "FBgn0051342", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469368": { "compartment": "compartment_70101", "id": "reaction_10469368", "reactome": "R-DME-3928615", "name": "EFNBs bind SFKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444516", "species_10469222" ], "products": [ "species_10469366" ], "modifiers": [], "additional_components": [ "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733" ] }, "reaction_10469400": { "compartment": "compartment_70101", "id": "reaction_10469400", "reactome": "R-DME-3928625", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469391" ], "products": [ "species_29370", "species_10469397" ], "modifiers": [ [ "species_10469391", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469431": { "compartment": "compartment_70101", "id": "reaction_10469431", "reactome": "R-DME-3928639", "name": "p-EFNB binds GRB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444514", "species_10469352" ], "products": [ "species_10469354" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock" ] }, "reaction_10469429": { "compartment": "compartment_876", "id": "reaction_10469429", "reactome": "R-DME-3928633", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442464", "species_29438", "species_10469387" ], "products": [ "species_114549", "species_10469389" ], "modifiers": [ [ "species_10469387", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539" ] }, "reaction_10469364": { "compartment": "compartment_70101", "id": "reaction_10469364", "reactome": "R-DME-3928614", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469360", "species_10469354" ], "products": [ "species_10469362" ], "modifiers": [], "additional_components": [ "FBgn0033539", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539" ] }, "reaction_10469426": { "compartment": "compartment_70101", "id": "reaction_10469426", "reactome": "R-DME-3928631", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469362", "species_10439144" ], "products": [ "species_10469387" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "FBgn0015803", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539" ] }, "reaction_10469457": { "compartment": "compartment_876", "id": "reaction_10469457", "reactome": "R-DME-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10469454", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VVC6", "FBgn0261547" ] }, "reaction_10469385": { "compartment": "compartment_876", "id": "reaction_10469385", "reactome": "R-DME-3928624", "name": "EPHBs bind EFNBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469206", "species_10469212" ], "products": [ "species_10469222" ], "modifiers": [], "additional_components": [ "FBgn0040324", "FBgn0025936", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469320": { "compartment": "compartment_876", "id": "reaction_10469320", "reactome": "R-DME-3928597", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469293" ], "products": [ "species_10469291" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469447": { "compartment": "compartment_876", "id": "reaction_10469447", "reactome": "R-DME-3928646", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469184", "species_10469171" ], "products": [ "species_10469202" ], "modifiers": [], "additional_components": [ "FBgn0025936", "FBgn0040324", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936" ] }, "reaction_10469285": { "compartment": "compartment_70101", "id": "reaction_10469285", "reactome": "R-DME-3928578", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469226" ], "products": [ "species_10469282", "species_29370" ], "modifiers": [ [ "species_10469226", "catalyst" ] ], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469657": { "compartment": "compartment_876", "id": "reaction_10469657", "reactome": "R-DME-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10469418", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "P91621", "FBgn0085447", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382" ] }, "reaction_10469304": { "compartment": "compartment_70101", "id": "reaction_10469304", "reactome": "R-DME-3928592", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10469301", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "M9PBE1", "FBgn0032796" ] }, "reaction_10469654": { "compartment": "compartment_876", "id": "reaction_10469654", "reactome": "R-DME-4093332", "name": "p-EPHB phosphorylates SDC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10461274" ], "products": [ "species_10469651", "species_29370" ], "modifiers": [ [ "species_10469280", "catalyst" ] ], "additional_components": [ "FBgn0010415", "FBgn0010415", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936" ] }, "reaction_10469647": { "compartment": "compartment_70101", "id": "reaction_10469647", "reactome": "R-DME-4093331", "name": "Ras:GTP binds p120-RasGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_206703", "species_10469643" ], "products": [ "species_10469645" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29438", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "P08646", "RAS85D", "species_29438" ] }, "reaction_10469166": { "compartment": "compartment_876", "id": "reaction_10469166", "reactome": "R-DME-3928576", "name": "RHOA:GTP binds ROCK, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604", "species_10434906" ], "products": [ "species_10447647" ], "modifiers": [], "additional_components": [ "FBgn0026181", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181" ] }, "reaction_10469421": { "compartment": "compartment_70101", "id": "reaction_10469421", "reactome": "R-DME-3928627", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469413", "species_113592" ], "products": [ "species_29370", "species_10469418" ], "modifiers": [ [ "species_10469413", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P91621", "FBgn0085447", "P91621", "FBgn0085447", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P91621", "FBgn0085447" ] }, "reaction_10469322": { "compartment": "compartment_876", "id": "reaction_10469322", "reactome": "R-DME-3928601", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469312", "species_179856" ], "products": [ "species_10469314" ], "modifiers": [], "additional_components": [ "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341", "species_179856", "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10469383": { "compartment": "compartment_70101", "id": "reaction_10469383", "reactome": "R-DME-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469374" ], "products": [ "species_10469380", "species_29370" ], "modifiers": [ [ "species_10469374", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469318": { "compartment": "compartment_876", "id": "reaction_10469318", "reactome": "R-DME-3928595", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469314", "species_10461790", "species_10442127" ], "products": [ "species_10469316" ], "modifiers": [], "additional_components": [ "species_179856", "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "species_179856", "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10469445": { "compartment": "compartment_70101", "id": "reaction_10469445", "reactome": "R-DME-3928645", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442480", "species_10469411" ], "products": [ "species_10469413" ], "modifiers": [], "additional_components": [ "FBgn0085447", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P91621", "FBgn0085447" ] }, "reaction_10469668": { "compartment": "compartment_876", "id": "reaction_10469668", "reactome": "R-DME-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469651" ], "products": [ "species_10469666" ], "modifiers": [], "additional_components": [ "FBgn0010415", "P49415", "FBgn0010415" ] }, "reaction_10469376": { "compartment": "compartment_876", "id": "reaction_10469376", "reactome": "R-DME-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_10442466" ], "products": [ "species_10469374" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469664": { "compartment": "compartment_876", "id": "reaction_10469664", "reactome": "R-DME-4093339", "name": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10469645" ], "products": [ "species_29372", "species_10469661" ], "modifiers": [ [ "species_10469645", "catalyst" ] ], "additional_components": [ "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "P08646", "RAS85D", "species_29438", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29420", "P08646", "RAS85D", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "P08646", "RAS85D", "species_29438" ] }, "reaction_10469503": { "compartment": "compartment_876", "id": "reaction_10469503", "reactome": "R-DME-3928656", "name": "gamma-secretase cleaves EPHB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469481" ], "products": [ "species_10469491", "species_10469501" ], "modifiers": [ [ "species_10458502", "catalyst" ] ], "additional_components": [ "FBgn0025936", "FBgn0025936", "FBgn0025936", "Q9VQG2", "FBgn0031458", "Q86BE9", "FBgn0053198", "O02194", "FBgn0284421", "Q9VC27", "FBgn0039234" ] }, "reaction_10469516": { "compartment": "compartment_876", "id": "reaction_10469516", "reactome": "R-DME-3928657", "name": "MMP2,9 cleave EPHB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469222" ], "products": [ "species_10469505", "species_10469206", "species_10469481" ], "modifiers": [ [ "species_10459272", "catalyst" ] ], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "FBgn0025936", "FBgn0040324", "FBgn0025936", "FBgn0035049" ] }, "reaction_10469479": { "compartment": "compartment_876", "id": "reaction_10469479", "reactome": "R-DME-3928654", "name": "Clathrin internalises EPH:EFN complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469475", "species_10439846", "species_10469222", "species_10469463", "species_10439790" ], "products": [ "species_10469477" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "FBgn0003392", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P27619", "FBgn0003392", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10469333": { "compartment": "compartment_876", "id": "reaction_10469333", "reactome": "R-DME-3928607", "name": "p-EPHs bind VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442473", "species_10469324" ], "products": [ "species_10469326" ], "modifiers": [], "additional_components": [ "FBgn0040068", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9NHV9", "FBgn0040068" ] }, "reaction_10469637": { "compartment": "compartment_70101", "id": "reaction_10469637", "reactome": "R-DME-4093327", "name": "EPHA binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442480", "species_10469438" ], "products": [ "species_10469440" ], "modifiers": [], "additional_components": [ "FBgn0085447", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "P91621", "FBgn0085447" ] }, "reaction_10469331": { "compartment": "compartment_876", "id": "reaction_10469331", "reactome": "R-DME-3928604", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469326" ], "products": [ "species_10469328", "species_29370" ], "modifiers": [ [ "species_10469326", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9NHV9", "FBgn0040068", "Q9NHV9", "FBgn0040068", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9NHV9", "FBgn0040068" ] }, "reaction_10469443": { "compartment": "compartment_876", "id": "reaction_10469443", "reactome": "R-DME-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10469440", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "P91621", "FBgn0085447" ] }, "reaction_10450221": { "compartment": "compartment_70101", "id": "reaction_10450221", "reactome": "R-DME-445079", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446836", "species_113592", "species_10433787" ], "products": [ "species_29370", "species_10450218" ], "modifiers": [ [ "species_10433787", "catalyst" ] ], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "FBgn0003256", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "P40417", "FBgn0003256", "Q8T390", "FBgn0038659", "FBgn0003256" ] }, "reaction_10453467": { "compartment": "compartment_876", "id": "reaction_10453467", "reactome": "R-DME-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438817", "species_10453462" ], "products": [ "species_29372", "species_29420", "species_10446836" ], "modifiers": [ [ "species_10439850", "catalyst" ] ], "additional_components": [ "FBgn0038659", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659" ] }, "reaction_10446838": { "compartment": "compartment_17940", "id": "reaction_10446838", "reactome": "R-DME-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446836" ], "products": [ "species_10446836" ], "modifiers": [], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659" ] }, "reaction_10444575": { "compartment": "compartment_70101", "id": "reaction_10444575", "reactome": "R-DME-373738", "name": "Neurofascin interacts with syntenin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444571", "species_10444543" ], "products": [ "species_10444573" ], "modifiers": [], "additional_components": [ "FBgn0051342", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "A8JQY9", "FBgn0051342" ] }, "reaction_10444553": { "compartment": "compartment_876", "id": "reaction_10444553", "reactome": "R-DME-373730", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444549", "species_10444543" ], "products": [ "species_10444551" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388" ] }, "reaction_10449908": { "compartment": "compartment_876", "id": "reaction_10449908", "reactome": "R-DME-443774", "name": "Trans-homodimerization of Neurofascin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449904", "species_10444543" ], "products": [ "species_10449906" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q0KIE7", "FBgn0011747", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q0KIE7", "FBgn0011747" ] }, "reaction_10450094": { "compartment": "compartment_70101", "id": "reaction_10450094", "reactome": "R-DME-445064", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10449774", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "FBgn0040068" ] }, "reaction_10450214": { "compartment": "compartment_70101", "id": "reaction_10450214", "reactome": "R-DME-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_351067", "species_113592" ], "products": [ "species_10450211", "species_29370", "species_10446511" ], "modifiers": [ [ "species_10446511", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698", "FBgn0267698" ] }, "reaction_10433782": { "compartment": "compartment_70101", "id": "reaction_10433782", "reactome": "R-DME-109860", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10433757" ], "products": [ "species_29370", "species_10433773" ], "modifiers": [ [ "species_10433757", "catalyst" ], [ "species_10433778", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10433792": { "compartment": "compartment_70101", "id": "reaction_10433792", "reactome": "R-DME-109862", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433765", "species_113592" ], "products": [ "species_29370", "species_10433789" ], "modifiers": [ [ "species_10433765", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10497559": { "compartment": "compartment_12045", "id": "reaction_10497559", "reactome": "R-DME-9614271", "name": "Autocleavage of ADGRG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497538" ], "products": [ "species_10497556" ], "modifiers": [ [ "species_10497538", "catalyst" ] ], "additional_components": [ "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818", "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818", "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818" ] }, "reaction_10497561": { "compartment": "compartment_876", "id": "reaction_10497561", "reactome": "R-DME-9614273", "name": "ADGRG heterodimer translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497556" ], "products": [ "species_10497556" ], "modifiers": [], "additional_components": [ "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818", "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818" ] }, "reaction_10437846": { "compartment": "compartment_70101", "id": "reaction_10437846", "reactome": "R-DME-170847", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437831", "species_10437838" ], "products": [ "species_10437844" ], "modifiers": [], "additional_components": [ "FBgn0011655", "FBgn0025800", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10437955": { "compartment": "compartment_70101", "id": "reaction_10437955", "reactome": "R-DME-173488", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437844" ], "products": [ "species_10437946" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10459921": { "compartment": "compartment_7660", "id": "reaction_10459921", "reactome": "R-DME-1535903", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1535904", "species_10437946", "species_10441099" ], "products": [ "species_10459919" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q95V55", "foxo", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10443101": { "compartment": "compartment_7660", "id": "reaction_10443101", "reactome": "R-DME-211164", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441097" ], "products": [ "species_113582", "species_10441108" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10443105": { "compartment": "compartment_7660", "id": "reaction_10443105", "reactome": "R-DME-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441108" ], "products": [ "species_10443103" ], "modifiers": [], "additional_components": [] }, "reaction_10486931": { "compartment": "compartment_70101", "id": "reaction_10486931", "reactome": "R-DME-6810843", "name": "Envoplakin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486927", "species_10486925" ], "products": [ "species_10486929" ], "modifiers": [], "additional_components": [ "FBgn0013733", "FBgn0013733", "A1Z9J3", "FBgn0013733" ] }, "reaction_10480300": { "compartment": "compartment_984", "id": "reaction_10480300", "reactome": "R-DME-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10480297", "catalyst" ] ], "additional_components": [ "Q9VPE9", "FBgn0036996", "Q9VG47", "FBgn0038069", "Q9VG46", "FBgn0038070", "Q9VBK6", "FBgn0051091", "Q9V9N3", "FBgn0032981", "Q8IMS3", "FBgn0051091", "Q59E63", "FBgn0034990", "Q9VQQ5", "FBgn0031533", "Q4V6L4", "FBgn0033999", "Q0KI77", "FBgn0038067", "Q9VKT8", "FBgn0032265", "O46108", "FBgn0023495", "Q9VKT7", "FBgn0032266", "O46107", "FBgn0023496", "Q9VKT2", "FBgn0032271", "M9PCU5", "FBgn0032264", "Q9VKT1", "FBgn0051872", "E2QCS7", "FBgn0265264", "Q9VKS9", "FBgn0043825", "Q9VKS5", "FBgn0051871", "Q9VKR5", "FBgn0024740", "Q9VG50", "FBgn0042207", "Q9VG48", "FBgn0038068" ] }, "reaction_10487309": { "compartment": "compartment_876", "id": "reaction_10487309", "reactome": "R-DME-6814187", "name": "EVL:PPL heterodimer binds the inner surface of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10486929" ], "products": [ "species_10486933" ], "modifiers": [], "additional_components": [ "A1Z9J3", "FBgn0013733", "A1Z9J3", "FBgn0013733" ] }, "reaction_10487326": { "compartment": "compartment_70101", "id": "reaction_10487326", "reactome": "R-DME-6814374", "name": "Kazrin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486927", "species_10487322" ], "products": [ "species_10487324" ], "modifiers": [], "additional_components": [ "FBgn0013733", "FBgn0034720", "A8DYM0", "FBgn0034720", "A1Z9J3", "FBgn0013733" ] }, "reaction_10444879": { "compartment": "compartment_876", "id": "reaction_10444879", "reactome": "R-DME-375138", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444869", "species_10444875" ], "products": [ "species_10444877" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388" ] }, "reaction_10450726": { "compartment": "compartment_876", "id": "reaction_10450726", "reactome": "R-DME-448958", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450724" ], "products": [ "species_10450672", "species_10450722" ], "modifiers": [], "additional_components": [ "P00522", "Abl", "Q9VZJ4", "FBgn0035488", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "species_29438", "P40793", "FBgn0010341", "Q9GQF1", "FBgn0024187", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P00522", "Abl", "Q9VZJ4", "FBgn0035488", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "species_29438", "P40793", "FBgn0010341", "Q9GQF1", "FBgn0024187" ] }, "reaction_10450755": { "compartment": "compartment_7660", "id": "reaction_10450755", "reactome": "R-DME-448963", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450683", "species_10450751" ], "products": [ "species_10450753" ], "modifiers": [], "additional_components": [ "P40791", "FBgn0011656", "P11420", "FBgn0267821", "P22816", "FBgn0002922", "P11420", "FBgn0267821", "P22816", "FBgn0002922", "P40791", "FBgn0011656" ] }, "reaction_10444914": { "compartment": "compartment_876", "id": "reaction_10444914", "reactome": "R-DME-375140", "name": "CDO binds promyogenic cadherins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444877", "species_10444910" ], "products": [ "species_10444912" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388" ] }, "reaction_10450688": { "compartment": "compartment_7660", "id": "reaction_10450688", "reactome": "R-DME-448955", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450672", "species_10450656", "species_29358" ], "products": [ "species_113582", "species_10450685" ], "modifiers": [ [ "species_10450672", "catalyst" ] ], "additional_components": [ "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "FBgn0011656", "P40791", "FBgn0011656", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846" ] }, "reaction_10445986": { "compartment": "compartment_7660", "id": "reaction_10445986", "reactome": "R-DME-381262", "name": "Formation of PPARG:RXRA heterodimer (ARF6 complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440428", "species_10445293" ], "products": [ "species_10445984" ], "modifiers": [], "additional_components": [ "FBgn0003964", "FBgn0000568", "P13055", "FBgn0000568", "P20153", "FBgn0003964" ] }, "reaction_10497719": { "compartment": "compartment_7660", "id": "reaction_10497719", "reactome": "R-DME-9624112", "name": "CEBPA binds CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432391", "species_10497715" ], "products": [ "species_10497717" ], "modifiers": [], "additional_components": [ "FBgn0016131", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q7K306", "FBgn0016131" ] }, "reaction_10497723": { "compartment": "compartment_7660", "id": "reaction_10497723", "reactome": "R-DME-9624120", "name": "CEBPA binds CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427334", "species_10497715" ], "products": [ "species_10497721" ], "modifiers": [], "additional_components": [ "FBgn0004107", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "P23573", "FBgn0004107" ] }, "reaction_10497614": { "compartment": "compartment_7660", "id": "reaction_10497614", "reactome": "R-DME-9617067", "name": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497606", "species_5334804" ], "products": [ "species_10497612" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "species_5334816", "P13055", "FBgn0000568" ] }, "reaction_10430843": { "compartment": "compartment_70101", "id": "reaction_10430843", "reactome": "R-DME-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430839", "species_10430461" ], "products": [ "species_10430463" ], "modifiers": [], "additional_components": [ "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136" ] }, "reaction_10430537": { "compartment": "compartment_70101", "id": "reaction_10430537", "reactome": "R-DME-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72393", "species_10430459" ], "products": [ "species_10430461" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438" ] }, "reaction_10430535": { "compartment": "compartment_70101", "id": "reaction_10430535", "reactome": "R-DME-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10430457" ], "products": [ "species_10430459" ], "modifiers": [], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438" ] }, "reaction_10465097": { "compartment": "compartment_70101", "id": "reaction_10465097", "reactome": "R-DME-2161779", "name": "LXA4 is oxidised to 15k-LXA4 by HPGD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161759", "species_29360" ], "products": [ "species_70106", "species_2142761", "species_73473" ], "modifiers": [ [ "species_10465094", "catalyst" ] ], "additional_components": [ "Q9I7R3", "FBgn0042137" ] }, "reaction_10496834": { "compartment": "compartment_70101", "id": "reaction_10496834", "reactome": "R-DME-9018868", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020583", "species_29450" ], "products": [ "species_29356", "species_9020474", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496829": { "compartment": "compartment_70101", "id": "reaction_10496829", "reactome": "R-DME-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496973": { "compartment": "compartment_70101", "id": "reaction_10496973", "reactome": "R-DME-9023968", "name": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9022660", "species_29360" ], "products": [ "species_9023963", "species_73473" ], "modifiers": [ [ "species_10465094", "catalyst" ] ], "additional_components": [ "Q9I7R3", "FBgn0042137" ] }, "reaction_10496836": { "compartment": "compartment_70101", "id": "reaction_10496836", "reactome": "R-DME-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9023708" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496838": { "compartment": "compartment_70101", "id": "reaction_10496838", "reactome": "R-DME-9018895", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023653", "species_29450" ], "products": [ "species_29356", "species_9023651", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496848": { "compartment": "compartment_70101", "id": "reaction_10496848", "reactome": "R-DME-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:138615", "CHEBI:138616", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496850": { "compartment": "compartment_70101", "id": "reaction_10496850", "reactome": "R-DME-9020271", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024522" ], "products": [ "species_29356", "species_9024463", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496840": { "compartment": "compartment_70101", "id": "reaction_10496840", "reactome": "R-DME-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024602" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10497011": { "compartment": "compartment_70101", "id": "reaction_10497011", "reactome": "R-DME-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10432773", "catalyst" ] ], "additional_components": [ "Q95078", "FBgn0010383", "Q9VWR5", "FBgn0004959" ] }, "reaction_10496852": { "compartment": "compartment_70101", "id": "reaction_10496852", "reactome": "R-DME-9020273", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024012" ], "products": [ "species_29356", "species_9024815", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496842": { "compartment": "compartment_70101", "id": "reaction_10496842", "reactome": "R-DME-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024781" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10497004": { "compartment": "compartment_70101", "id": "reaction_10497004", "reactome": "R-DME-9024766", "name": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024764", "species_29360" ], "products": [ "species_9024799", "species_73473" ], "modifiers": [ [ "species_10465094", "catalyst" ] ], "additional_components": [ "CHEBI:132797", "CHEBI:132800", "Q9I7R3", "FBgn0042137" ] }, "reaction_10496846": { "compartment": "compartment_70101", "id": "reaction_10496846", "reactome": "R-DME-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "species_9024764", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496844": { "compartment": "compartment_70101", "id": "reaction_10496844", "reactome": "R-DME-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024893" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10497006": { "compartment": "compartment_70101", "id": "reaction_10497006", "reactome": "R-DME-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10450926": { "compartment": "compartment_70101", "id": "reaction_10450926", "reactome": "R-DME-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437429" ], "products": [ "species_10437365" ], "modifiers": [], "additional_components": [] }, "reaction_10437443": { "compartment": "compartment_70101", "id": "reaction_10437443", "reactome": "R-DME-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_10437429", "species_29370" ], "modifiers": [ [ "species_10437440", "catalyst" ] ], "additional_components": [ "FBgn0024326" ] }, "reaction_10450893": { "compartment": "compartment_70101", "id": "reaction_10450893", "reactome": "R-DME-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450883" ], "products": [ "species_10450889" ], "modifiers": [], "additional_components": [ "FBgn0261524", "FBgn0261524" ] }, "reaction_10450918": { "compartment": "compartment_7660", "id": "reaction_10450918", "reactome": "R-DME-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10450915" ], "products": [ "species_113582", "species_10450840" ], "modifiers": [ [ "species_10450889", "catalyst" ] ], "additional_components": [ "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "FBgn0261524" ] }, "reaction_10450853": { "compartment": "compartment_70101", "id": "reaction_10450853", "reactome": "R-DME-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450846" ], "products": [ "species_10450851" ], "modifiers": [], "additional_components": [ "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765" ] }, "reaction_10450849": { "compartment": "compartment_7660", "id": "reaction_10450849", "reactome": "R-DME-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10450840" ], "products": [ "species_113582", "species_10450846" ], "modifiers": [ [ "species_10450840", "catalyst" ] ], "additional_components": [ "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987" ] }, "reaction_10450876": { "compartment": "compartment_7660", "id": "reaction_10450876", "reactome": "R-DME-450292", "name": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450872", "species_10437390" ], "products": [ "species_10450874" ], "modifiers": [], "additional_components": [ "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550", "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550" ] }, "reaction_10437382": { "compartment": "compartment_7660", "id": "reaction_10437382", "reactome": "R-DME-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437328", "species_29358" ], "products": [ "species_113582", "species_10437332" ], "modifiers": [ [ "species_10437379", "catalyst" ] ], "additional_components": [ "FBgn0265193", "FBgn0265193", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P92208", "bsk" ] }, "reaction_10450901": { "compartment": "compartment_7660", "id": "reaction_10450901", "reactome": "R-DME-450325", "name": "c-FOS activation by phospho ERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10450899" ], "products": [ "species_113582", "species_10450872" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550", "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550", "P40417", "FBgn0003256" ] }, "reaction_10437461": { "compartment": "compartment_7660", "id": "reaction_10437461", "reactome": "R-DME-168440", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437332", "species_10437390" ], "products": [ "species_10437459" ], "modifiers": [], "additional_components": [ "FBgn0265193", "P18289", "phospho-Jra", "Q2PE13", "FBgn0265193" ] }, "reaction_10437393": { "compartment": "compartment_7660", "id": "reaction_10437393", "reactome": "R-DME-168136", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437386" ], "products": [ "species_113582", "species_10437390" ], "modifiers": [ [ "species_10437365", "catalyst" ] ], "additional_components": [] }, "reaction_10463567": { "compartment": "compartment_20699", "id": "reaction_10463567", "reactome": "R-DME-2022851", "name": "EXT1:EXT2 transfer GlcNAc to the heparan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10463526" ], "products": [ "species_10463552", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10463662": { "compartment": "compartment_20699", "id": "reaction_10463662", "reactome": "R-DME-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10463622" ], "products": [ "species_10463648", "species_742343" ], "modifiers": [ [ "species_10463653", "catalyst" ] ], "additional_components": [ "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "FBgn0020251" ] }, "reaction_10464814": { "compartment": "compartment_20699", "id": "reaction_10464814", "reactome": "R-DME-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463809", "species_741440" ], "products": [ "species_742343", "species_10463831" ], "modifiers": [ [ "species_10464807", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "FBgn0038755" ] }, "reaction_10463596": { "compartment": "compartment_20699", "id": "reaction_10463596", "reactome": "R-DME-2022856", "name": "EXT1:EXT2 transfers GlcNAc to heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10463593" ], "products": [ "species_10463526", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10463691": { "compartment": "compartment_20699", "id": "reaction_10463691", "reactome": "R-DME-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_10463688" ], "products": [ "species_10463622", "species_2022890" ], "modifiers": [ [ "species_10463653", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "FBgn0020251" ] }, "reaction_10463947": { "compartment": "compartment_17963", "id": "reaction_10463947", "reactome": "R-DME-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463833" ], "products": [ "species_10463945" ], "modifiers": [], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally" ] }, "reaction_10464822": { "compartment": "compartment_20699", "id": "reaction_10464822", "reactome": "R-DME-2076508", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463731", "species_741440" ], "products": [ "species_742343", "species_10463757" ], "modifiers": [ [ "species_10464819", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "FBgn0024230" ] }, "reaction_10464836": { "compartment": "compartment_20699", "id": "reaction_10464836", "reactome": "R-DME-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10463757" ], "products": [ "species_742343", "species_10463783" ], "modifiers": [ [ "species_10464833", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "Q8MRE7", "FBgn0053147", "Q9VWJ7", "FBgn0031005" ] }, "reaction_10463699": { "compartment": "compartment_20699", "id": "reaction_10463699", "reactome": "R-DME-2022919", "name": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463697", "species_914003" ], "products": [ "species_10463593", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10464802": { "compartment": "compartment_20699", "id": "reaction_10464802", "reactome": "R-DME-2076392", "name": "EXT1:EXT2 transfers GlcA to heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463552", "species_1889970" ], "products": [ "species_10463688", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10464800": { "compartment": "compartment_17963", "id": "reaction_10464800", "reactome": "R-DME-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10463757" ], "products": [ "species_742343", "species_10463783" ], "modifiers": [ [ "species_10464795", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "FBgn0053147" ] }, "reaction_10497796": { "compartment": "compartment_70101", "id": "reaction_10497796", "reactome": "R-DME-9630923", "name": "NFkB inhibitor binds NFkB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411", "species_10437415" ], "products": [ "species_10437417" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl" ] }, "reaction_10437457": { "compartment": "compartment_70101", "id": "reaction_10437457", "reactome": "R-DME-168166", "name": "NFkB complex is transported from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10468309": { "compartment": "compartment_7660", "id": "reaction_10468309", "reactome": "R-DME-3322427", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468258", "species_10447242" ], "products": [ "species_10468307" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0261617", "M9MS40", "FBgn0261617", "P18824", "arm", "Q8IMA8", "FBgn0085432" ] }, "reaction_10468260": { "compartment": "compartment_7660", "id": "reaction_10468260", "reactome": "R-DME-3299569", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468256", "species_10441673" ], "products": [ "species_10468258", "species_10457450", "species_10468252" ], "modifiers": [], "additional_components": [ "P16371", "GRO", "Q94517", "HDAC1", "Q8IMA8", "FBgn0085432", "P18824", "arm", "Q8IMA8", "FBgn0085432", "P16371", "GRO" ] }, "reaction_10468305": { "compartment": "compartment_7660", "id": "reaction_10468305", "reactome": "R-DME-3322424", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434736", "species_10468258", "species_10434726" ], "products": [ "species_10468303" ], "modifiers": [], "additional_components": [ "FBgn0019637", "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0037657", "Q9VHI1", "FBgn0037657", "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q94546", "FBgn0019637" ] }, "reaction_10468464": { "compartment": "compartment_7660", "id": "reaction_10468464", "reactome": "R-DME-3364014", "name": "Recruitment of SET1 methyltransferase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468432", "species_10468437", "species_10465286", "species_10468442", "species_10468460" ], "products": [ "species_10468462" ], "modifiers": [], "additional_components": [ "FBgn0023518", "FBgn0000139", "FBgn0031885", "FBgn0036973", "Q9V9W8", "PYGO", "Q961D9", "LGS", "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q9VPH8", "FBgn0036973", "Q9V9W8", "PYGO", "Q961D9", "LGS", "P18824", "arm", "Q9VM47", "FBgn0031885", "Q94545", "FBgn0000139", "Q8IMA8", "FBgn0085432", "Q8IRW8", "FBgn0023518" ] }, "reaction_10441675": { "compartment": "compartment_70101", "id": "reaction_10441675", "reactome": "R-DME-201669", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440609" ], "products": [ "species_10441673" ], "modifiers": [], "additional_components": [] }, "reaction_10468687": { "compartment": "compartment_70101", "id": "reaction_10468687", "reactome": "R-DME-3640844", "name": "RNF146 binds RibC-AXIN:TNKS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468683", "species_10468669" ], "products": [ "species_10468685" ], "modifiers": [], "additional_components": [ "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "FBgn0036897", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn" ] }, "reaction_10468716": { "compartment": "compartment_70101", "id": "reaction_10468716", "reactome": "R-DME-3640874", "name": "Ub-RibC-AXIN is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468701" ], "products": [ "species_10468679", "species_10426987", "species_10468669" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "B7Z078", "FBgn0036897", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "FBgn0027508", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0036897", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10468694": { "compartment": "compartment_70101", "id": "reaction_10468694", "reactome": "R-DME-3640858", "name": "Tankyrase ADP-ribosylates AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468691", "species_29360" ], "products": [ "species_197277", "species_10468683" ], "modifiers": [ [ "species_10468691", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508" ] }, "reaction_10470006": { "compartment": "compartment_70101", "id": "reaction_10470006", "reactome": "R-DME-4641134", "name": "SMURF2 binds AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437960", "species_10440493" ], "products": [ "species_10469994" ], "modifiers": [], "additional_components": [ "FBgn0029006", "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006" ] }, "reaction_10470021": { "compartment": "compartment_70101", "id": "reaction_10470021", "reactome": "R-DME-4641256", "name": "Ubiquitinated AXIN is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470001" ], "products": [ "species_10437960", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006", "FBgn0029006", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10470004": { "compartment": "compartment_70101", "id": "reaction_10470004", "reactome": "R-DME-4641129", "name": "AXIN is ubiquitinated by SMURF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469994", "species_10426987" ], "products": [ "species_10470001" ], "modifiers": [ [ "species_10469994", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006", "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006" ] }, "reaction_10468706": { "compartment": "compartment_70101", "id": "reaction_10468706", "reactome": "R-DME-3640862", "name": "Tankyrase binds AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468679", "species_10440493" ], "products": [ "species_10468691" ], "modifiers": [], "additional_components": [ "FBgn0027508", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508" ] }, "reaction_10468704": { "compartment": "compartment_70101", "id": "reaction_10468704", "reactome": "R-DME-3640861", "name": "RNF146 ubiquitinates ADP-ribosylated AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10468685" ], "products": [ "species_10468701" ], "modifiers": [ [ "species_10468685", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "B7Z078", "FBgn0036897", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn" ] }, "reaction_10468714": { "compartment": "compartment_70101", "id": "reaction_10468714", "reactome": "R-DME-3640872", "name": "USP34 deubiquitinates AXIN1,AXIN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10468701" ], "products": [ "species_10426987", "species_10468685" ], "modifiers": [ [ "species_10468711", "catalyst" ] ], "additional_components": [ "B7Z078", "FBgn0036897", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "FBgn0039214" ] }, "reaction_10472015": { "compartment": "compartment_7660", "id": "reaction_10472015", "reactome": "R-DME-5368580", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441673", "species_10472011" ], "products": [ "species_10472013" ], "modifiers": [], "additional_components": [ "FBgn0266557", "B7Z002", "FBgn0266557", "P18824", "arm" ] }, "reaction_10475439": { "compartment": "compartment_7660", "id": "reaction_10475439", "reactome": "R-DME-5665608", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468258", "species_10475435" ], "products": [ "species_10475437" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "P18824", "arm", "Q8IMA8", "FBgn0085432" ] }, "reaction_10468798": { "compartment": "compartment_7660", "id": "reaction_10468798", "reactome": "R-DME-3769391", "name": "XPO1 binds the beta-catenin:CBY complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468794", "species_10437629" ], "products": [ "species_10468796" ], "modifiers": [], "additional_components": [ "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta", "FBgn0020497", "Q9TVM2", "FBgn0020497", "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta" ] }, "reaction_10468427": { "compartment": "compartment_7660", "id": "reaction_10468427", "reactome": "R-DME-3361751", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468421", "species_10468423" ], "products": [ "species_10468256", "species_10468425" ], "modifiers": [], "additional_components": [ "O46036", "FBgn0020496", "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P16371", "GRO", "Q94517", "HDAC1", "P16371", "GRO", "Q94517", "HDAC1", "Q8IMA8", "FBgn0085432", "O46036", "FBgn0020496", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589" ] }, "reaction_10468810": { "compartment": "compartment_7660", "id": "reaction_10468810", "reactome": "R-DME-3769394", "name": "AKT phosphorylates CBY1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10468785" ], "products": [ "species_113582", "species_10468792" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "B9A0M5", "FBgn0067317", "P18824", "arm", "P18824", "arm", "B9A0M5", "FBgn0067317" ] }, "reaction_10468345": { "compartment": "compartment_7660", "id": "reaction_10468345", "reactome": "R-DME-3322434", "name": "XIAP dissociates from ub-TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468338" ], "products": [ "species_10468336", "species_10468315" ], "modifiers": [], "additional_components": [ "Q24307", "Diap2", "Q24306", "Diap1", "P16371", "GRO", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10468808": { "compartment": "compartment_7660", "id": "reaction_10468808", "reactome": "R-DME-3769393", "name": "YWHAZ binds p-CBY:CTNNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451202", "species_10468792" ], "products": [ "species_10468794" ], "modifiers": [], "additional_components": [ "P18824", "arm", "B9A0M5", "FBgn0067317", "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta" ] }, "reaction_10468343": { "compartment": "compartment_7660", "id": "reaction_10468343", "reactome": "R-DME-3322431", "name": "XIAP binds TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468315", "species_10468252" ], "products": [ "species_10468317" ], "modifiers": [], "additional_components": [ "Q24307", "Diap2", "Q24306", "Diap1", "P16371", "GRO", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10468806": { "compartment": "compartment_70101", "id": "reaction_10468806", "reactome": "R-DME-3769392", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468796" ], "products": [ "species_10468804" ], "modifiers": [], "additional_components": [ "Q9TVM2", "FBgn0020497", "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "B9A0M5", "FBgn0067317", "P18824", "arm", "Q9TVM2", "FBgn0020497" ] }, "reaction_10468341": { "compartment": "compartment_7660", "id": "reaction_10468341", "reactome": "R-DME-3322429", "name": "XIAP monoubiquinates TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10468317" ], "products": [ "species_10468338" ], "modifiers": [ [ "species_10468317", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "P16371", "GRO", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10474292": { "compartment": "compartment_7660", "id": "reaction_10474292", "reactome": "R-DME-5626938", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474288", "species_10441673" ], "products": [ "species_10474290" ], "modifiers": [], "additional_components": [ "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "Q9VA17", "FBgn0024288", "P18824", "arm", "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "Q9VA17", "FBgn0024288" ] }, "reaction_10468787": { "compartment": "compartment_7660", "id": "reaction_10468787", "reactome": "R-DME-3769383", "name": "CBY1 binds beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441673", "species_10468783" ], "products": [ "species_10468785" ], "modifiers": [], "additional_components": [ "FBgn0067317", "B9A0M5", "FBgn0067317", "P18824", "arm" ] }, "reaction_10441753": { "compartment": "compartment_876", "id": "reaction_10441753", "reactome": "R-DME-201677", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441725" ], "products": [ "species_29370", "species_10441750" ], "modifiers": [ [ "species_10441725", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880", "P09615", "WG", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P18537", "FZ", "P51140", "phospho-dsh", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880", "Q9VLZ6", "FBgn0031926", "A1Z9D7", "FBgn0000119", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880" ] }, "reaction_10459892": { "compartment": "compartment_70101", "id": "reaction_10459892", "reactome": "R-DME-1504186", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441723", "species_10441677" ], "products": [ "species_10441725" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880" ] }, "reaction_10468814": { "compartment": "compartment_70101", "id": "reaction_10468814", "reactome": "R-DME-3772434", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460946", "species_10441717" ], "products": [ "species_10468812" ], "modifiers": [], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984", "P51140", "phospho-dsh", "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10468824": { "compartment": "compartment_70101", "id": "reaction_10468824", "reactome": "R-DME-3772436", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10468812", "catalyst" ] ], "additional_components": [ "P51140", "phospho-dsh", "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10468821": { "compartment": "compartment_70101", "id": "reaction_10468821", "reactome": "R-DME-3772435", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441766" ], "products": [ "species_29370", "species_10441717" ], "modifiers": [ [ "species_10468818", "catalyst" ] ], "additional_components": [] }, "reaction_10441793": { "compartment": "compartment_70101", "id": "reaction_10441793", "reactome": "R-DME-201717", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441759" ], "products": [ "species_29370", "species_10441766" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10471507": { "compartment": "compartment_984", "id": "reaction_10471507", "reactome": "R-DME-5323545", "name": "Canonical WNT signaling through the atypical receptor RYK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471501", "species_10471503" ], "products": [ "species_10471505" ], "modifiers": [], "additional_components": [ "FBgn0024245", "P09615", "WG", "P28466", "FBgn0010194", "P09615", "WG", "P28466", "FBgn0010194", "Q9V422", "FBgn0024245" ] }, "reaction_10470012": { "compartment": "compartment_70101", "id": "reaction_10470012", "reactome": "R-DME-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470008", "species_10441759" ], "products": [ "species_10470010" ], "modifiers": [], "additional_components": [ "FBgn0261931", "P51140", "phospho-dsh", "Q9W326", "FBgn0261931" ] }, "reaction_10470023": { "compartment": "compartment_70101", "id": "reaction_10470023", "reactome": "R-DME-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470014" ], "products": [ "species_10470008", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9W326", "FBgn0261931", "P51140", "phospho-dsh", "FBgn0261931", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10459910": { "compartment": "compartment_70101", "id": "reaction_10459910", "reactome": "R-DME-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459898", "species_10426987" ], "products": [ "species_10459907" ], "modifiers": [ [ "species_10459898", "catalyst" ] ], "additional_components": [ "Q8IP45", "FBgn0261268", "Q9W5E1", "Roc1a", "P51140", "phospho-dsh", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P51140", "phospho-dsh", "Q8IP45", "FBgn0261268", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9W5E1", "Roc1a", "P51140", "phospho-dsh" ] }, "reaction_10470017": { "compartment": "compartment_70101", "id": "reaction_10470017", "reactome": "R-DME-4641159", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470010", "species_10426987" ], "products": [ "species_10470014" ], "modifiers": [ [ "species_10470010", "catalyst" ] ], "additional_components": [ "P51140", "phospho-dsh", "Q9W326", "FBgn0261931", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W326", "FBgn0261931", "P51140", "phospho-dsh", "P51140", "phospho-dsh", "Q9W326", "FBgn0261931" ] }, "reaction_10496688": { "compartment": "compartment_876", "id": "reaction_10496688", "reactome": "R-DME-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496685" ], "products": [ "species_29420", "species_10496660" ], "modifiers": [ [ "species_10496685", "catalyst" ] ], "additional_components": [ "Q0KHU4", "FBgn0083940", "species_29420", "Q0KHU4", "FBgn0083940", "species_29438", "Q0KHU4", "FBgn0083940", "species_29420" ] }, "reaction_10496683": { "compartment": "compartment_876", "id": "reaction_10496683", "reactome": "R-DME-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496679", "species_10496660" ], "products": [ "species_10496681" ], "modifiers": [], "additional_components": [ "Q9VXE5", "FBgn0025743", "Q9VIS1", "FBgn0032821", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "Q0KHU4", "FBgn0083940", "species_29438", "Q0KHU4", "FBgn0083940", "species_29438", "Q9VXE5", "FBgn0025743", "Q9VIS1", "FBgn0032821", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698" ] }, "reaction_10496403": { "compartment": "compartment_876", "id": "reaction_10496403", "reactome": "R-DME-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464321", "species_10440312" ], "products": [ "species_10496401" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29420", "Q9VW59", "RhoGDI" ] }, "reaction_10496358": { "compartment": "compartment_876", "id": "reaction_10496358", "reactome": "R-DME-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067", "species_29356" ], "products": [ "species_10464321", "species_29372" ], "modifiers": [ [ "species_10496355", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29420", "Q9VWL7", "FBgn0261461", "X2JEI9", "FBgn0031118", "Q9VDS5", "FBgn0038747", "Q9VDG2", "FBgn0026056", "Q0E938", "FBgn0028494", "Q9VIS1", "FBgn0032821", "Q9W4A9", "FBgn0029778", "Q9V9S7", "FBgn0039883", "Q9VDE9", "RhoGAP93B", "B7Z058", "FBgn0036518" ] }, "reaction_10496311": { "compartment": "compartment_876", "id": "reaction_10496311", "reactome": "R-DME-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10464321" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10496308", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "P25157", "FBgn0000384", "Q9VAS8", "FBgn0264324", "Q9NHV9", "FBgn0040068", "P91621", "FBgn0085447" ] }, "reaction_10498558": { "compartment": "compartment_876", "id": "reaction_10498558", "reactome": "R-DME-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067" ], "products": [ "species_10498556" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10496399": { "compartment": "compartment_876", "id": "reaction_10496399", "reactome": "R-DME-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067", "species_10496395" ], "products": [ "species_10496397" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "O97111", "FBgn0026192", "B7YZT5", "FBgn0286511", "B7Z0W0", "FBgn0267698", "A1Z7T0", "FBgn0020621", "Q9W1B0", "FBgn0023081", "Q8IQE6", "FBgn0052082", "Q7K490", "FBgn0033996", "Q9VXE5", "FBgn0025743", "M9PE53", "FBgn0264272", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "Q9VF87", "FBgn0038320", "O97111", "FBgn0026192", "B7YZT5", "FBgn0286511", "B7Z0W0", "FBgn0267698", "A1Z7T0", "FBgn0020621", "Q9W1B0", "FBgn0023081", "Q8IQE6", "FBgn0052082", "Q7K490", "FBgn0033996", "Q9VXE5", "FBgn0025743", "M9PE53", "FBgn0264272", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10498562": { "compartment": "compartment_876", "id": "reaction_10498562", "reactome": "R-DME-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439139" ], "products": [ "species_10498560" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "P40793", "FBgn0010341", "species_29438" ] }, "reaction_10496452": { "compartment": "compartment_876", "id": "reaction_10496452", "reactome": "R-DME-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10439139" ], "products": [ "species_29372", "species_10496432" ], "modifiers": [ [ "species_10496449", "catalyst" ] ], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "species_29420", "P40793", "FBgn0010341", "Q9VX92", "FBgn0030808", "Q9VDE9", "RhoGAP93B", "Q8T0G4", "FBgn0039994", "Q9VTU3", "FBgn0036257", "B7Z058", "FBgn0036518", "Q0E938", "FBgn0028494" ] }, "reaction_10496438": { "compartment": "compartment_876", "id": "reaction_10496438", "reactome": "R-DME-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440312", "species_10496432" ], "products": [ "species_10496436" ], "modifiers": [], "additional_components": [ "species_29420", "P40793", "FBgn0010341", "P40793", "FBgn0010341", "species_29420", "Q9VW59", "RhoGDI" ] }, "reaction_10496445": { "compartment": "compartment_876", "id": "reaction_10496445", "reactome": "R-DME-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496432" ], "products": [ "species_29420", "species_10439139" ], "modifiers": [ [ "species_10496442", "catalyst" ] ], "additional_components": [ "species_29420", "P40793", "FBgn0010341", "species_29438", "P40793", "FBgn0010341", "P25157", "FBgn0000384", "A1ZBA1", "FBgn0050115", "Q9W0S2", "FBgn0264707", "Q9VVC6", "FBgn0261547", "Q7KU89", "FBgn0035802", "Q7K4E0", "FBgn0050440" ] }, "reaction_10498596": { "compartment": "compartment_876", "id": "reaction_10498596", "reactome": "R-DME-9693125", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498572", "species_10498592" ], "products": [ "species_10498594" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "A8JQT5", "FBgn0265082", "P48608", "FBgn0011202", "Q8IQE6", "FBgn0052082", "A8JQT5", "FBgn0265082", "P48608", "FBgn0011202", "Q8IQE6", "FBgn0052082", "P48148", "Rho1", "species_29438" ] }, "reaction_10498649": { "compartment": "compartment_876", "id": "reaction_10498649", "reactome": "R-DME-9693282", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10498572" ], "products": [ "species_29372", "species_10498570" ], "modifiers": [ [ "species_10498646", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29438", "species_29420", "P48148", "Rho1", "Q9VTU3", "FBgn0036257" ] }, "reaction_10498575": { "compartment": "compartment_876", "id": "reaction_10498575", "reactome": "R-DME-9693111", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10498570" ], "products": [ "species_29420", "species_10498572" ], "modifiers": [ [ "species_10498570", "catalyst" ] ], "additional_components": [ "species_29420", "P48148", "Rho1", "P48148", "Rho1", "species_29438", "species_29420", "P48148", "Rho1" ] }, "reaction_10496723": { "compartment": "compartment_876", "id": "reaction_10496723", "reactome": "R-DME-9018778", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496719", "species_10496695" ], "products": [ "species_10496721" ], "modifiers": [], "additional_components": [ "Q9VJ79", "FBgn0085370", "Q9VFI9", "FBgn0038237", "Q9VXE3", "FBgn0026181", "Q8IP45", "FBgn0261268", "M9PG08", "FBgn0036980", "species_29438", "M9PG08", "FBgn0036980", "species_29438", "Q9VJ79", "FBgn0085370", "Q9VFI9", "FBgn0038237", "Q9VXE3", "FBgn0026181", "Q8IP45", "FBgn0261268" ] }, "reaction_10496697": { "compartment": "compartment_74700", "id": "reaction_10496697", "reactome": "R-DME-9018774", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496693" ], "products": [ "species_10496695" ], "modifiers": [], "additional_components": [ "FBgn0036980", "M9PG08", "FBgn0036980", "species_29438" ] }, "reaction_10496752": { "compartment": "compartment_74700", "id": "reaction_10496752", "reactome": "R-DME-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496748", "species_10496727" ], "products": [ "species_10496750" ], "modifiers": [], "additional_components": [ "Q9VVE5", "FBgn0260943", "Q8IP45", "FBgn0261268", "M9PG08", "FBgn0036980", "species_29438", "M9PG08", "FBgn0036980", "species_29438", "Q9VVE5", "FBgn0260943", "Q8IP45", "FBgn0261268" ] }, "reaction_10496732": { "compartment": "compartment_70101", "id": "reaction_10496732", "reactome": "R-DME-9018785", "name": "RHOBTB2 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496725" ], "products": [ "species_10496727" ], "modifiers": [ [ "species_10496729", "catalyst" ] ], "additional_components": [ "FBgn0036980", "M9PG08", "FBgn0036980", "species_29438", "P02828", "FBgn0001233", "Q24276", "FBgn0011573" ] }, "reaction_10496496": { "compartment": "compartment_876", "id": "reaction_10496496", "reactome": "R-DME-9013452", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460" ], "products": [ "species_10475550" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438" ] }, "reaction_10498627": { "compartment": "compartment_876", "id": "reaction_10498627", "reactome": "R-DME-9693243", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460" ], "products": [ "species_10498625" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "species_29438", "P48148", "Rho1" ] }, "reaction_10496468": { "compartment": "compartment_876", "id": "reaction_10496468", "reactome": "R-DME-9013437", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496460" ], "products": [ "species_29372", "species_10496456" ], "modifiers": [ [ "species_10496465", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420", "Q9VIS1", "FBgn0032821", "Q9VX32", "RhoGAPp190", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685" ] }, "reaction_10498644": { "compartment": "compartment_20699", "id": "reaction_10498644", "reactome": "R-DME-9693250", "name": "RHOD binds effectors at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498625", "species_10498640" ], "products": [ "species_10498642" ], "modifiers": [], "additional_components": [ "species_29438", "P48148", "Rho1", "Q8SX68", "FBgn0034308", "Q8SX68", "FBgn0034308", "species_29438", "P48148", "Rho1" ] }, "reaction_10498613": { "compartment": "compartment_876", "id": "reaction_10498613", "reactome": "R-DME-9693207", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460" ], "products": [ "species_10498611" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438" ] }, "reaction_10498621": { "compartment": "compartment_17906", "id": "reaction_10498621", "reactome": "R-DME-9693214", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498617", "species_10498611" ], "products": [ "species_10498619" ], "modifiers": [], "additional_components": [ "Q9VXE5", "FBgn0025743", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE5", "FBgn0025743" ] }, "reaction_10496494": { "compartment": "compartment_876", "id": "reaction_10496494", "reactome": "R-DME-9013438", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496490", "species_10475550" ], "products": [ "species_10496492" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "Q9VPY3", "FBgn0031317", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "Q9VPY3", "FBgn0031317" ] }, "reaction_10496463": { "compartment": "compartment_876", "id": "reaction_10496463", "reactome": "R-DME-9013435", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496456" ], "products": [ "species_29420", "species_10496460" ], "modifiers": [ [ "species_10496456", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420" ] }, "reaction_10498607": { "compartment": "compartment_70101", "id": "reaction_10498607", "reactome": "R-DME-9693198", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460", "species_10498603" ], "products": [ "species_10498605" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "P48603", "FBgn0011570", "Q9VDE9", "RhoGAP93B", "Q9VJ26", "FBgn0032731", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P18091", "FBgn0000667", "Q02645", "FBgn0263391", "O76742", "FBgn0015795", "Q9VU84", "FBgn0036372", "P08928", "FBgn0002525", "Q8IPI3", "FBgn0259111", "Q9VTU3", "FBgn0036257", "Q9VW40", "FBgn0036908", "P48608", "FBgn0011202", "P48603", "FBgn0011570", "Q9VDE9", "RhoGAP93B", "Q9VJ26", "FBgn0032731", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P18091", "FBgn0000667", "Q02645", "FBgn0263391", "O76742", "FBgn0015795", "Q9VU84", "FBgn0036372", "P08928", "FBgn0002525", "Q8IPI3", "FBgn0259111", "Q9VTU3", "FBgn0036257", "Q9VW40", "FBgn0036908", "P48148", "Rho1", "species_29438" ] }, "reaction_10496514": { "compartment": "compartment_70101", "id": "reaction_10496514", "reactome": "R-DME-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496508", "species_10440312" ], "products": [ "species_10496512" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29420", "Q9VW59", "RhoGDI", "species_29420", "P48554", "FBgn0014011", "P40792", "RAC1_DROME" ] }, "reaction_10496532": { "compartment": "compartment_70101", "id": "reaction_10496532", "reactome": "R-DME-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496508" ], "products": [ "species_10434896", "species_29420" ], "modifiers": [ [ "species_10496529", "catalyst" ] ], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29420", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "X2JC00", "FBgn0025836", "Q9NHV9", "FBgn0040068", "Q7K4E0", "FBgn0050440", "P91621", "FBgn0085447" ] }, "reaction_10496534": { "compartment": "compartment_876", "id": "reaction_10496534", "reactome": "R-DME-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896" ], "products": [ "species_10475589" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10498823": { "compartment": "compartment_876", "id": "reaction_10498823", "reactome": "R-DME-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896" ], "products": [ "species_10498821" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10496522": { "compartment": "compartment_70101", "id": "reaction_10496522", "reactome": "R-DME-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896", "species_10496518" ], "products": [ "species_10496520" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "B7YZT5", "FBgn0286511", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "B7YZT5", "FBgn0286511", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10498813": { "compartment": "compartment_17906", "id": "reaction_10498813", "reactome": "R-DME-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498797", "species_10498809" ], "products": [ "species_10498811" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496527": { "compartment": "compartment_70101", "id": "reaction_10496527", "reactome": "R-DME-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896", "species_29356" ], "products": [ "species_29372", "species_10496508" ], "modifiers": [ [ "species_10496524", "catalyst" ] ], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29420", "Q9VX32", "RhoGAPp190", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685" ] }, "reaction_10498815": { "compartment": "compartment_876", "id": "reaction_10498815", "reactome": "R-DME-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896" ], "products": [ "species_10498797" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496786": { "compartment": "compartment_876", "id": "reaction_10496786", "reactome": "R-DME-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496782", "species_10496756" ], "products": [ "species_10496784" ], "modifiers": [], "additional_components": [ "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "Q0KHU4", "FBgn0083940", "species_29438", "Q0KHU4", "FBgn0083940", "species_29438", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698" ] }, "reaction_10496790": { "compartment": "compartment_876", "id": "reaction_10496790", "reactome": "R-DME-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496788" ], "products": [ "species_29420", "species_10496756" ], "modifiers": [], "additional_components": [ "Q0KHU4", "FBgn0083940", "species_29420", "Q0KHU4", "FBgn0083940", "species_29438" ] }, "reaction_10495680": { "compartment": "compartment_70101", "id": "reaction_10495680", "reactome": "R-DME-8981637", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10434906" ], "products": [ "species_29372", "species_10434904" ], "modifiers": [ [ "species_10495677", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420", "X2JDY8", "FBgn0030685", "Q9VX32", "RhoGAPp190", "Q8T0G4", "FBgn0039994", "A1ZAW3", "FBgn0034249", "H9XVN1", "FBgn0259216", "Q9VIS1", "FBgn0032821", "B7Z058", "FBgn0036518", "Q9VTU3", "FBgn0036257", "A8JR05", "FBgn0285955" ] }, "reaction_10496244": { "compartment": "compartment_70101", "id": "reaction_10496244", "reactome": "R-DME-9012835", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440312", "species_10434904" ], "products": [ "species_10496242" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29420", "Q9VW59", "RhoGDI" ] }, "reaction_10496248": { "compartment": "compartment_876", "id": "reaction_10496248", "reactome": "R-DME-9013006", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434906" ], "products": [ "species_10496246" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438" ] }, "reaction_10495532": { "compartment": "compartment_70101", "id": "reaction_10495532", "reactome": "R-DME-8980691", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10495529", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "M9PBE1", "FBgn0032796", "Q9VVC6", "FBgn0261547", "Q8IQ97", "FBgn0003041", "Q9NHV9", "FBgn0040068", "A1ZAN6", "FBgn0023172", "M9PHU0", "FBgn0263706", "Q7K4E0", "FBgn0050440", "Q9VW85", "FBgn0261556", "Q7KVD1", "FBgn0024277" ] }, "reaction_10496302": { "compartment": "compartment_876", "id": "reaction_10496302", "reactome": "R-DME-9013009", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496298", "species_10434906" ], "products": [ "species_10496300" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "B7YZT5", "FBgn0286511", "Q9XYY9", "FBgn0026374", "Q9W179", "FBgn0035001", "A1Z7T0", "FBgn0020621", "Q9VXE3", "FBgn0026181", "Q9V4P1", "FBgn0261385", "M9MSM5", "FBgn0025641", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "B7YZT5", "FBgn0286511", "Q9XYY9", "FBgn0026374", "Q9W179", "FBgn0035001", "A1Z7T0", "FBgn0020621", "Q9VXE3", "FBgn0026181", "Q9V4P1", "FBgn0261385", "M9MSM5", "FBgn0025641" ] }, "reaction_10496569": { "compartment": "compartment_876", "id": "reaction_10496569", "reactome": "R-DME-9017488", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496562" ], "products": [ "species_29372", "species_10496564" ], "modifiers": [ [ "species_10496566", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "P40793", "FBgn0010341", "species_29420", "Q9VX32", "RhoGAPp190", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685" ] }, "reaction_10496572": { "compartment": "compartment_876", "id": "reaction_10496572", "reactome": "R-DME-9017491", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496564" ], "products": [ "species_29420", "species_10496562" ], "modifiers": [ [ "species_10457618", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "species_29420", "P40793", "FBgn0010341", "species_29438", "FBgn0031216" ] }, "reaction_10496609": { "compartment": "compartment_70101", "id": "reaction_10496609", "reactome": "R-DME-9018746", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496591", "species_10496605" ], "products": [ "species_10496607" ], "modifiers": [], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "Q9VIS1", "FBgn0032821", "A8JNK4", "FBgn0035533", "B7Z0W0", "FBgn0267698", "Q9VIS1", "FBgn0032821", "A8JNK4", "FBgn0035533", "B7Z0W0", "FBgn0267698", "P40793", "FBgn0010341", "species_29438" ] }, "reaction_10496614": { "compartment": "compartment_876", "id": "reaction_10496614", "reactome": "R-DME-9018747", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496593" ], "products": [ "species_10496591", "species_29420" ], "modifiers": [ [ "species_10496611", "catalyst" ] ], "additional_components": [ "species_29420", "P40793", "FBgn0010341", "P40793", "FBgn0010341", "species_29438", "M9ND00", "FBgn0023388" ] }, "reaction_10496598": { "compartment": "compartment_70101", "id": "reaction_10496598", "reactome": "R-DME-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496591", "species_29356" ], "products": [ "species_29372", "species_10496593" ], "modifiers": [ [ "species_10496595", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "species_29420", "P40793", "FBgn0010341", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685", "A8JR05", "FBgn0285955" ] }, "reaction_10496826": { "compartment": "compartment_876", "id": "reaction_10496826", "reactome": "R-DME-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496591" ], "products": [ "species_10496824" ], "modifiers": [], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "P40793", "FBgn0010341", "species_29438" ] }, "reaction_10496626": { "compartment": "compartment_876", "id": "reaction_10496626", "reactome": "R-DME-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496622", "species_10440312" ], "products": [ "species_10496624" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "Q9VW59", "RhoGDI", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496628": { "compartment": "compartment_876", "id": "reaction_10496628", "reactome": "R-DME-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496620" ], "products": [ "species_10496622" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496653": { "compartment": "compartment_876", "id": "reaction_10496653", "reactome": "R-DME-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496622", "species_10496649" ], "products": [ "species_10496651" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10455477": { "compartment": "compartment_20699", "id": "reaction_10455477", "reactome": "R-DME-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10455474", "catalyst" ] ], "additional_components": [ "P53624", "FBgn0259170", "Q8IMK0", "FBgn0051202" ] }, "reaction_10455523": { "compartment": "compartment_20699", "id": "reaction_10455523", "reactome": "R-DME-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10455474", "catalyst" ] ], "additional_components": [ "P53624", "FBgn0259170", "Q8IMK0", "FBgn0051202" ] }, "reaction_10455521": { "compartment": "compartment_20699", "id": "reaction_10455521", "reactome": "R-DME-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10455474", "catalyst" ] ], "additional_components": [ "CHEBI:60629", "CHEBI:60628", "CHEBI:60627", "P53624", "FBgn0259170", "Q8IMK0", "FBgn0051202" ] }, "reaction_10461309": { "compartment": "compartment_161320", "id": "reaction_10461309", "reactome": "R-DME-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10461306", "catalyst" ] ], "additional_components": [ "FBgn0014417" ] }, "reaction_10464861": { "compartment": "compartment_17938", "id": "reaction_10464861", "reactome": "R-DME-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_2090045" ], "products": [ "species_2090053", "species_76194" ], "modifiers": [ [ "species_10461235", "catalyst" ] ], "additional_components": [ "Q9W4F7", "FBgn0029737" ] }, "reaction_10464859": { "compartment": "compartment_161320", "id": "reaction_10464859", "reactome": "R-DME-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_1605637", "species_2090063" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_10463705": { "compartment": "compartment_876", "id": "reaction_10463705", "reactome": "R-DME-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461260" ], "products": [ "species_10460901" ], "modifiers": [], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "Q24114", "dally" ] }, "reaction_10464857": { "compartment": "compartment_161320", "id": "reaction_10464857", "reactome": "R-DME-2090043", "name": "SGSH hydrolyses Heparan sulfate chain(7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090070" ], "products": [ "species_1606845", "species_2090045" ], "modifiers": [ [ "species_10461290", "catalyst" ] ], "additional_components": [ "FBgn0038660" ] }, "reaction_10464855": { "compartment": "compartment_161320", "id": "reaction_10464855", "reactome": "R-DME-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_1678743", "species_2065212" ], "modifiers": [ [ "species_10461306", "catalyst" ] ], "additional_components": [ "FBgn0014417" ] }, "reaction_10461238": { "compartment": "compartment_17938", "id": "reaction_10461238", "reactome": "R-DME-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_2090069", "species_76194" ], "modifiers": [ [ "species_10461235", "catalyst" ] ], "additional_components": [ "Q9W4F7", "FBgn0029737" ] }, "reaction_10461301": { "compartment": "compartment_161320", "id": "reaction_10461301", "reactome": "R-DME-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090033", "species_1605715" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10461298", "catalyst" ] ], "additional_components": [ "FBgn0032343" ] }, "reaction_10464853": { "compartment": "compartment_161320", "id": "reaction_10464853", "reactome": "R-DME-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090055" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10461298", "catalyst" ] ], "additional_components": [ "FBgn0032343" ] }, "reaction_10461293": { "compartment": "compartment_161320", "id": "reaction_10461293", "reactome": "R-DME-1678708", "name": "SGSH hydrolyses Heparan sulfate chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090072" ], "products": [ "species_2090040", "species_1606845" ], "modifiers": [ [ "species_10461290", "catalyst" ] ], "additional_components": [ "FBgn0038660" ] }, "reaction_10461228": { "compartment": "compartment_161320", "id": "reaction_10461228", "reactome": "R-DME-1678650", "name": "IDS hydrolyses Heparan sulfate chain(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090080", "species_1605715" ], "products": [ "species_2090055", "species_1606845" ], "modifiers": [ [ "species_10461225", "catalyst" ] ], "additional_components": [ "Q9VZP8", "FBgn0035445", "species_74016" ] }, "reaction_10460935": { "compartment": "compartment_161320", "id": "reaction_10460935", "reactome": "R-DME-1667005", "name": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10460901" ], "products": [ "species_2090033", "species_10460923" ], "modifiers": [ [ "species_10460932", "catalyst" ] ], "additional_components": [ "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VE79", "FBgn0038611" ] }, "reaction_10461351": { "compartment": "compartment_161320", "id": "reaction_10461351", "reactome": "R-DME-1678854", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065212" ], "products": [ "species_1678868", "species_2090075" ], "modifiers": [ [ "species_10461348", "catalyst" ], [ "species_427963", "inhibitor" ] ], "additional_components": [ "A1ZBG9", "FBgn0034417" ] }, "reaction_10461285": { "compartment": "compartment_876", "id": "reaction_10461285", "reactome": "R-DME-1678694", "name": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10461260" ], "products": [ "species_10461280", "species_2090023" ], "modifiers": [ [ "species_10461282", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "FBgn0038611" ] }, "reaction_10496818": { "compartment": "compartment_70101", "id": "reaction_10496818", "reactome": "R-DME-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496814", "species_10496796" ], "products": [ "species_10496816" ], "modifiers": [], "additional_components": [ "Q960V3", "FBgn0262872", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "Q8IMX7", "Miro", "species_29438", "Q8IMX7", "Miro", "species_29438", "Q960V3", "FBgn0262872", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596" ] }, "reaction_10496820": { "compartment": "compartment_70101", "id": "reaction_10496820", "reactome": "R-DME-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496796" ], "products": [ "species_10496798", "species_29372" ], "modifiers": [ [ "species_10496796", "catalyst" ] ], "additional_components": [ "Q8IMX7", "Miro", "species_29438", "Q8IMX7", "Miro", "species_29420", "Q8IMX7", "Miro", "species_29438" ] }, "reaction_10448207": { "compartment": "compartment_20699", "id": "reaction_10448207", "reactome": "R-DME-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10448204", "catalyst" ] ], "additional_components": [ "Q9VPJ1", "FBgn0026787", "Q8IPJ4", "FBgn0028703" ] }, "reaction_10448172": { "compartment": "compartment_172574", "id": "reaction_10448172", "reactome": "R-DME-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10448169", "catalyst" ] ], "additional_components": [ "FBgn0028703" ] }, "reaction_10448195": { "compartment": "compartment_876", "id": "reaction_10448195", "reactome": "R-DME-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10448184", "catalyst" ] ], "additional_components": [ "FBgn0040297" ] }, "reaction_10448179": { "compartment": "compartment_171062", "id": "reaction_10448179", "reactome": "R-DME-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10448174", "catalyst" ] ], "additional_components": [ "FBgn0028703" ] }, "reaction_209074": { "compartment": "compartment_984", "id": "reaction_209074", "reactome": "R-DME-209074", "name": "WG, FZ and ARR bind to each other", "reversible": "false", "notes": "The extracellular ligand Wingless (WG) binds to the extracellular domains of the plasma membrane Frizzled (FZ/FZ2) and Arrow (ARR) receptors. Both of these transmembrane receptors additionally interact with each other.", "reactants": [ "species_206202", "species_205797", "species_206546" ], "products": [ "species_206872" ], "modifiers": [], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR" ] }, "reaction_209108": { "compartment": "compartment_876", "id": "reaction_209108", "reactome": "R-DME-209108", "name": "Membrane-bound GISH binds to ARR receptor complex", "reversible": "false", "notes": "The plasma membrane tethered CKIgamma orthologue, GISH, complexes with the cytoplasmic tail of Arrow (ARR).", "reactants": [ "species_205695", "species_206872" ], "products": [ "species_206907" ], "modifiers": [], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH" ] }, "reaction_209135": { "compartment": "compartment_70101", "id": "reaction_209135", "reactome": "R-DME-209135", "name": "GISH further phosphorylates ARR in the receptor complex", "reversible": "false", "notes": "The bound kinase GISH phosphorylates two further residues on Arrow's (ARR) tail. Thr1493 and Thr1479 in Human LRP6 are phosphorylated by CKIgamma.", "reactants": [ "species_113592", "species_206800" ], "products": [ "species_29370", "species_206613" ], "modifiers": [ [ "species_206800", "catalyst" ] ], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "Q95V09", "ARR", "P09615", "WG", "Q86BR9", "GISH", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P18537", "FZ", "Q9VVX3", "FZ2", "Q95V09", "ARR", "P09615", "WG", "Q86BR9", "GISH" ] }, "reaction_209118": { "compartment": "compartment_70101", "id": "reaction_209118", "reactome": "R-DME-209118", "name": "Membrane localised SGG phosphorylates ARR", "reversible": "false", "notes": "The resulting transmembrane co-receptor complex is now primed for phosphorylation on the C-terminal tail of Arrow (ARR) by a membrane localised Shaggy (SGG). Ser1490 in Human LRP6 is phosphorylated by GSK3beta.", "reactants": [ "species_113592", "species_206907" ], "products": [ "species_29370", "species_206800" ], "modifiers": [ [ "species_5263693", "catalyst" ] ], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P18537", "FZ", "Q9VVX3", "FZ2", "Q95V09", "ARR", "P09615", "WG", "Q86BR9", "GISH" ] }, "reaction_10481336": { "compartment": "compartment_876", "id": "reaction_10481336", "reactome": "R-DME-6798258", "name": "PRTPRF, PTPRS, PTPRD bind LRRC4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481332", "species_10446397" ], "products": [ "species_10481334" ], "modifiers": [], "additional_components": [ "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "FBgn0000464", "P16621", "FBgn0000464", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435" ] }, "reaction_10446403": { "compartment": "compartment_70101", "id": "reaction_10446403", "reactome": "R-DME-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446392", "species_10446397" ], "products": [ "species_10446401" ], "modifiers": [], "additional_components": [ "Q9VU88", "FBgn0036376", "M9PCD4", "FBgn0046704", "FBgn0000464", "P16621", "FBgn0000464", "Q9VU88", "FBgn0036376", "M9PCD4", "FBgn0046704" ] }, "reaction_10481248": { "compartment": "compartment_876", "id": "reaction_10481248", "reactome": "R-DME-6797554", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442084", "species_10481244" ], "products": [ "species_10481246" ], "modifiers": [], "additional_components": [ "FBgn0036372", "A1Z9K8", "FBgn0040752", "Q7KT70", "FBgn0001987", "Q9W1B3", "FBgn0034972", "Q9VIC7", "FBgn0051146", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "Q7K1T1", "FBgn0259978", "A1Z9K8", "FBgn0040752", "Q7KT70", "FBgn0001987", "Q9W1B3", "FBgn0034972", "Q9VIC7", "FBgn0051146", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "Q7K1T1", "FBgn0259978", "Q9VU84", "FBgn0036372" ] }, "reaction_10481136": { "compartment": "compartment_70101", "id": "reaction_10481136", "reactome": "R-DME-6797553", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445828", "species_10481132" ], "products": [ "species_10481134" ], "modifiers": [], "additional_components": [ "FBgn0013759", "Q9VFU8", "FBgn0004049", "Q9V8R9", "FBgn0010434", "Q9VFU8", "FBgn0004049", "Q9V8R9", "FBgn0010434", "Q24210", "FBgn0013759" ] }, "reaction_10488289": { "compartment": "compartment_876", "id": "reaction_10488289", "reactome": "R-DME-8849906", "name": "SALM1 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488267", "species_10488250" ], "products": [ "species_10488287" ], "modifiers": [], "additional_components": [ "FBgn0031016", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "Q9VWI6", "FBgn0031016" ] }, "reaction_10488305": { "compartment": "compartment_876", "id": "reaction_10488305", "reactome": "R-DME-8849908", "name": "SALM4 binds flotillin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488301", "species_10488265" ], "products": [ "species_10488303" ], "modifiers": [], "additional_components": [ "O61492", "FBgn0264078", "FBgn0031016", "Q9VWI6", "FBgn0031016", "O61492", "FBgn0264078" ] }, "reaction_10488275": { "compartment": "compartment_876", "id": "reaction_10488275", "reactome": "R-DME-8849882", "name": "SALMs 1-4 bind reticulon 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488271", "species_10488265" ], "products": [ "species_10488273" ], "modifiers": [], "additional_components": [ "FBgn0053113", "FBgn0031016", "Q9VWI6", "FBgn0031016", "E1JHT6", "FBgn0053113" ] }, "reaction_10488263": { "compartment": "compartment_876", "id": "reaction_10488263", "reactome": "R-DME-8849881", "name": "SALM2 associate with AMPA and NMDA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488259", "species_10488257" ], "products": [ "species_10488261" ], "modifiers": [], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "FBgn0031016", "Q9VWI6", "FBgn0031016", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382" ] }, "reaction_10488281": { "compartment": "compartment_876", "id": "reaction_10488281", "reactome": "R-DME-8849891", "name": "SALMs 1-3 bind to PSD-95 family members", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488277", "species_10488257" ], "products": [ "species_10488279" ], "modifiers": [], "additional_components": [ "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "FBgn0031016", "Q9VWI6", "FBgn0031016", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624" ] }, "reaction_10488252": { "compartment": "compartment_876", "id": "reaction_10488252", "reactome": "R-DME-8849878", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488248", "species_10449288" ], "products": [ "species_10488250" ], "modifiers": [], "additional_components": [ "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382" ] }, "reaction_10489100": { "compartment": "compartment_876", "id": "reaction_10489100", "reactome": "R-DME-8855648", "name": "SALM3 binds LAR-RPTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488269", "species_10446397" ], "products": [ "species_10489098" ], "modifiers": [], "additional_components": [ "FBgn0031016", "FBgn0000464", "P16621", "FBgn0000464", "Q9VWI6", "FBgn0031016" ] }, "reaction_10488285": { "compartment": "compartment_876", "id": "reaction_10488285", "reactome": "R-DME-8849900", "name": "SALMs1-3 bind each other in cis interactions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488257" ], "products": [ "species_10488283" ], "modifiers": [], "additional_components": [ "FBgn0031016", "Q9VWI6", "FBgn0031016" ] }, "reaction_10453051": { "compartment": "compartment_984", "id": "reaction_10453051", "reactome": "R-DME-500717", "name": "Activation of GRIK3 homomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446852", "species_10453044" ], "products": [ "species_10453048" ], "modifiers": [ [ "species_10453044", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382", "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382" ] }, "reaction_10453046": { "compartment": "compartment_984", "id": "reaction_10453046", "reactome": "R-DME-500708", "name": "GRIK3 homomer binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10451326" ], "products": [ "species_10453044" ], "modifiers": [], "additional_components": [ "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382" ] }, "reaction_10451534": { "compartment": "compartment_984", "id": "reaction_10451534", "reactome": "R-DME-451309", "name": "Edited Kainate Receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10451530" ], "products": [ "species_10451532" ], "modifiers": [], "additional_components": [ "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "species_352022", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "species_352022", "species_210382" ] }, "reaction_10451537": { "compartment": "compartment_984", "id": "reaction_10451537", "reactome": "R-DME-451310", "name": "Activation of Edited Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10451532", "catalyst" ] ], "additional_components": [ "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "species_352022", "species_210382" ] }, "reaction_10451406": { "compartment": "compartment_876", "id": "reaction_10451406", "reactome": "R-DME-451283", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10451402" ], "products": [ "species_10451404" ], "modifiers": [], "additional_components": [ "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "species_352022", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "species_352022", "species_210382" ] }, "reaction_10451540": { "compartment": "compartment_70101", "id": "reaction_10451540", "reactome": "R-DME-451311", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10451404", "catalyst" ] ], "additional_components": [ "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "species_352022", "species_210382" ] }, "reaction_10442563": { "compartment": "compartment_70101", "id": "reaction_10442563", "reactome": "R-DME-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442464", "species_29438" ], "products": [ "species_10442466", "species_29420" ], "modifiers": [ [ "species_10442560", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "A1ZAN6", "FBgn0023172", "A1ZBA1", "FBgn0050115", "Q9W0S2", "FBgn0264707", "Q8IQ97", "FBgn0003041", "A8DZ19", "FBgn0015803", "Q9VVC6", "FBgn0261547", "Q7K4E0", "FBgn0050440", "P26675", "Sos", "P91621", "FBgn0085447", "M9PBE1", "FBgn0032796", "M9ND00", "FBgn0023388", "X2JC00", "FBgn0025836", "P25157", "FBgn0000384", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VW85", "FBgn0261556" ] }, "reaction_10440306": { "compartment": "compartment_13231", "id": "reaction_10440306", "reactome": "R-DME-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437429" ], "products": [ "species_10437365" ], "modifiers": [], "additional_components": [] }, "reaction_10442593": { "compartment": "compartment_70101", "id": "reaction_10442593", "reactome": "R-DME-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_29370", "species_10437429" ], "modifiers": [ [ "species_10442466", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10432761": { "compartment": "compartment_7660", "id": "reaction_10432761", "reactome": "R-DME-76056", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432757", "species_10432697" ], "products": [ "species_10432759" ], "modifiers": [], "additional_components": [ "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463" ] }, "reaction_10457699": { "compartment": "compartment_70101", "id": "reaction_10457699", "reactome": "R-DME-1013020", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10457696", "catalyst" ] ], "additional_components": [ "B7YZX2", "FBgn0032706", "species_352011", "Q9V3Q9", "FBgn0260446", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_216283": { "compartment": "compartment_7660", "id": "reaction_216283", "reactome": "R-DME-216283", "name": "RDX binds to and ubiquitinates CI", "reversible": "false", "notes": "HIB or Roadkill (RDX) is transcriptionally induced by Hedgehog signalling and binds directly to Cubitus Interruptus (CI), likely in competition with Supressor of Fused (SU(FU)), to link CI with a Cul3 aka guftagu (GFT)-based E3 ubiquitin ligase complex, leading to degradation of active nuclear CI.", "reactants": [ "species_216110", "species_216104", "species_205911" ], "products": [ "species_216204" ], "modifiers": [ [ "species_216104", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VFP2", "rdx", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "Q9VFP2", "rdx", "P19538", "ci", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VFP2", "rdx", "Q9V475", "GFT", "Q9NHX0", "ROC1B" ] }, "reaction_216282": { "compartment": "compartment_7660", "id": "reaction_216282", "reactome": "R-DME-216282", "name": "Ubiquitinated CI is degraded by the proteasome complex", "reversible": "false", "notes": "The ubiquitinated Cubitus Interruptus (CI) is marked for degradation in the nucleus by the 26S proteasome complex.", "reactants": [ "species_216204" ], "products": [ "species_216110", "species_216104" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "Q9VFP2", "rdx", "P19538", "ci", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VFP2", "rdx", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_10497363": { "compartment": "compartment_17963", "id": "reaction_10497363", "reactome": "R-DME-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9604808", "species_735682" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10497360", "catalyst" ] ], "additional_components": [ "Q24157", "FBgn0000221", "A1Z8R4", "FBgn0050036", "A1Z8R5", "FBgn0050037", "A1Z8R6", "FBgn0053145", "Q95RP8", "FBgn0040373", "Q9VLS8", "FBgn0031988", "Q9VZA6", "FBgn0035558", "Q9VLT0", "FBgn0031986" ] }, "reaction_10439963": { "compartment": "compartment_70101", "id": "reaction_10439963", "reactome": "R-DME-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10439960", "catalyst" ] ], "additional_components": [ "P14773", "FBgn0263782" ] }, "reaction_10439993": { "compartment": "compartment_70101", "id": "reaction_10439993", "reactome": "R-DME-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29372", "species_29370", "species_113528", "species_191362" ], "modifiers": [ [ "species_10439990", "catalyst" ] ], "additional_components": [ "Q9VXQ3", "FBgn0030683" ] }, "reaction_10440468": { "compartment": "compartment_70101", "id": "reaction_10440468", "reactome": "R-DME-194698", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_194644", "species_29364" ], "products": [ "species_194633", "species_29366" ], "modifiers": [ [ "species_10440465", "catalyst" ] ], "additional_components": [ "FBgn0034657" ] }, "reaction_10487854": { "compartment": "compartment_70101", "id": "reaction_10487854", "reactome": "R-DME-8848215", "name": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_191293", "species_29356", "species_76194" ], "modifiers": [ [ "species_10487851", "catalyst" ] ], "additional_components": [ "Q9W0H6", "FBgn0035203" ] }, "reaction_10439953": { "compartment": "compartment_70101", "id": "reaction_10439953", "reactome": "R-DME-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_76183" ], "products": [ "species_29356", "species_191374", "species_76194" ], "modifiers": [ [ "species_10439950", "catalyst" ] ], "additional_components": [ "FBgn0010611" ] }, "reaction_10439983": { "compartment": "compartment_70101", "id": "reaction_10439983", "reactome": "R-DME-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10439980", "catalyst" ] ], "additional_components": [ "Q9VDC2", "FBgn0038876", "species_29926" ] }, "reaction_10440463": { "compartment": "compartment_13231", "id": "reaction_10440463", "reactome": "R-DME-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194725", "species_194688" ], "products": [ "species_194668", "species_194704" ], "modifiers": [ [ "species_10440460", "catalyst" ] ], "additional_components": [ "FBgn0034657" ] }, "reaction_10439948": { "compartment": "compartment_70101", "id": "reaction_10439948", "reactome": "R-DME-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10439942", "catalyst" ] ], "additional_components": [ "species_29926", "Q7KN61", "FBgn0025373", "Q9VS54", "FBgn0019662" ] }, "reaction_10439945": { "compartment": "compartment_70101", "id": "reaction_10439945", "reactome": "R-DME-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10439942", "catalyst" ] ], "additional_components": [ "species_29926", "Q7KN61", "FBgn0025373", "Q9VS54", "FBgn0019662" ] }, "reaction_10471177": { "compartment": "compartment_17957", "id": "reaction_10471177", "reactome": "R-DME-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10471174", "catalyst" ] ], "additional_components": [ "FBgn0052442" ] }, "reaction_10493848": { "compartment": "compartment_70101", "id": "reaction_10493848", "reactome": "R-DME-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10493845", "catalyst" ] ], "additional_components": [ "FBgn0051717" ] }, "reaction_10439973": { "compartment": "compartment_70101", "id": "reaction_10439973", "reactome": "R-DME-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10439970", "catalyst" ] ], "additional_components": [ "Q7K2V9", "FBgn0061359" ] }, "reaction_10440001": { "compartment": "compartment_70101", "id": "reaction_10440001", "reactome": "R-DME-191422", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191296" ], "products": [ "species_29370", "species_191403" ], "modifiers": [ [ "species_10439998", "catalyst" ] ], "additional_components": [ "FBgn0032811" ] }, "reaction_10429104": { "compartment": "compartment_70101", "id": "reaction_10429104", "reactome": "R-DME-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10429101", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "O77460", "FBgn0016687" ] }, "reaction_10458157": { "compartment": "compartment_7660", "id": "reaction_10458157", "reactome": "R-DME-1234172", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458144", "species_10458150" ], "products": [ "species_10437973", "species_10458154" ], "modifiers": [ [ "species_10458144", "catalyst" ] ], "additional_components": [ "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24167", "FBgn0266411", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411" ] }, "reaction_10458075": { "compartment": "compartment_70101", "id": "reaction_10458075", "reactome": "R-DME-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458071" ], "products": [ "species_10458073", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10458168": { "compartment": "compartment_70101", "id": "reaction_10458168", "reactome": "R-DME-1234183", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458032", "species_10458067" ], "products": [ "species_10458093" ], "modifiers": [], "additional_components": [ "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q24167", "FBgn0266411" ] }, "reaction_10458166": { "compartment": "compartment_7660", "id": "reaction_10458166", "reactome": "R-DME-1234181", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458085", "species_113671", "species_113685" ], "products": [ "species_10458134", "species_159942", "species_159939" ], "modifiers": [ [ "species_10458114", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "species_111793", "Q8SX21", "FBgn0264785", "species_351595" ] }, "reaction_10458117": { "compartment": "compartment_7660", "id": "reaction_10458117", "reactome": "R-DME-1234165", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458087", "species_113671", "species_113685" ], "products": [ "species_10458104", "species_159942", "species_159939" ], "modifiers": [ [ "species_10458114", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "species_111793", "Q8SX21", "FBgn0264785", "species_351595" ] }, "reaction_10458164": { "compartment": "compartment_70101", "id": "reaction_10458164", "reactome": "R-DME-1234177", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29368", "species_10458079" ], "products": [ "species_10458036", "species_29434", "species_113528" ], "modifiers": [ [ "species_10458067", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530" ] }, "reaction_10458146": { "compartment": "compartment_7660", "id": "reaction_10458146", "reactome": "R-DME-1234169", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458132", "species_10458142" ], "products": [ "species_10458144" ], "modifiers": [], "additional_components": [ "FBgn0266411", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411" ] }, "reaction_10458162": { "compartment": "compartment_70101", "id": "reaction_10458162", "reactome": "R-DME-1234175", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458154" ], "products": [ "species_10458043" ], "modifiers": [], "additional_components": [ "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24167", "FBgn0266411", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956" ] }, "reaction_10458160": { "compartment": "compartment_70101", "id": "reaction_10458160", "reactome": "R-DME-1234173", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_10458081", "species_29368" ], "products": [ "species_29434", "species_113528", "species_10458039" ], "modifiers": [ [ "species_10458067", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530" ] }, "reaction_10458096": { "compartment": "compartment_70101", "id": "reaction_10458096", "reactome": "R-DME-1234163", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458091", "species_10458093" ], "products": [ "species_10458069", "species_10427563" ], "modifiers": [ [ "species_10458093", "catalyst" ] ], "additional_components": [ "Q9Y165", "FBgn0027609", "P25867", "eff", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q24167", "FBgn0266411", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q24167", "FBgn0266411" ] }, "reaction_10479102": { "compartment": "compartment_5460", "id": "reaction_10479102", "reactome": "R-DME-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_5696194", "species_113573" ], "modifiers": [ [ "species_10479099", "catalyst" ] ], "additional_components": [ "FBgn0051713" ] }, "reaction_10468283": { "compartment": "compartment_984", "id": "reaction_10468283", "reactome": "R-DME-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_3299686" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10468280", "catalyst" ] ], "additional_components": [ "species_1562550", "species_209799", "P61851", "FBgn0003462" ] }, "reaction_10468411": { "compartment": "compartment_70101", "id": "reaction_10468411", "reactome": "R-DME-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_29408" ], "products": [ "species_10430994", "species_29356" ], "modifiers": [ [ "species_10468408", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "Q9V3P0", "FBgn0040309", "Q960M4", "FBgn0038570", "Q9VUM4", "FBgn0036490" ] }, "reaction_10468378": { "compartment": "compartment_70616", "id": "reaction_10468378", "reactome": "R-DME-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10436150" ], "products": [ "species_10436148", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "P84029", "FBgn0284248", "CHEBI:38573", "P84029", "FBgn0284248" ] }, "reaction_10470231": { "compartment": "compartment_17963", "id": "reaction_10470231", "reactome": "R-DME-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470229" ], "products": [ "species_10468280" ], "modifiers": [], "additional_components": [ "species_1562550", "species_209799", "P61851", "FBgn0003462", "species_1562550", "species_209799", "P61851", "FBgn0003462" ] }, "reaction_10468372": { "compartment": "compartment_5460", "id": "reaction_10468372", "reactome": "R-DME-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468350", "species_1614617" ], "products": [ "species_10468353", "species_113521" ], "modifiers": [ [ "species_10468369", "catalyst" ] ], "additional_components": [ "FBgn0035334", "FBgn0035334", "Q960M4", "FBgn0038570", "Q9VEJ0", "FBgn0038519" ] }, "reaction_10486317": { "compartment": "compartment_12045", "id": "reaction_10486317", "reactome": "R-DME-6807557", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_70106", "species_1222424", "species_29366" ], "modifiers": [ [ "species_10486314", "catalyst" ] ], "additional_components": [ "FBgn0085428" ] }, "reaction_10468272": { "compartment": "compartment_5460", "id": "reaction_10468272", "reactome": "R-DME-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_3299683" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10468269", "catalyst" ] ], "additional_components": [ "Q00637", "FBgn0010213", "species_266099" ] }, "reaction_10432650": { "compartment": "compartment_17951", "id": "reaction_10432650", "reactome": "R-DME-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_113535", "species_141343" ], "modifiers": [ [ "species_10432647", "catalyst" ] ], "additional_components": [ "species_71185", "species_29364", "P17336", "FBgn0000261" ] }, "reaction_10468778": { "compartment": "compartment_5460", "id": "reaction_10468778", "reactome": "R-DME-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468350", "species_3697881" ], "products": [ "species_10468353", "species_3697842", "species_113521" ], "modifiers": [ [ "species_10468367", "catalyst" ] ], "additional_components": [ "FBgn0035334", "FBgn0035334", "FBgn0038570" ] }, "reaction_10468775": { "compartment": "compartment_70101", "id": "reaction_10468775", "reactome": "R-DME-3697882", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_1222481" ], "products": [ "species_10430994", "species_29356", "species_1222379" ], "modifiers": [ [ "species_10468406", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "FBgn0038570" ] }, "reaction_10468293": { "compartment": "compartment_70101", "id": "reaction_10468293", "reactome": "R-DME-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10468290", "catalyst" ] ], "additional_components": [ "P61851", "FBgn0003462", "species_1562550", "species_209799" ] }, "reaction_10431013": { "compartment": "compartment_70101", "id": "reaction_10431013", "reactome": "R-DME-73646", "name": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430994", "species_70106", "species_29364" ], "products": [ "species_10430996", "species_29366" ], "modifiers": [ [ "species_10431010", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "species_113596", "Q9VNT5", "FBgn0037170", "P91938", "FBgn0020653" ] }, "reaction_10468833": { "compartment": "compartment_17927", "id": "reaction_10468833", "reactome": "R-DME-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10468830", "catalyst" ] ], "additional_components": [ "species_209799", "species_1562550", "P61851", "FBgn0003462" ] }, "reaction_10461593": { "compartment": "compartment_70101", "id": "reaction_10461593", "reactome": "R-DME-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10461590", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "species_74016", "P13217", "FBgn0262738" ] }, "reaction_10461704": { "compartment": "compartment_70101", "id": "reaction_10461704", "reactome": "R-DME-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10461569", "catalyst" ] ], "additional_components": [ "M9PHS8", "FBgn0030761", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10461652": { "compartment": "compartment_70101", "id": "reaction_10461652", "reactome": "R-DME-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_114520" ], "modifiers": [ [ "species_10461649", "catalyst" ] ], "additional_components": [ "Q7KMQ6", "Pten", "species_29926" ] }, "reaction_10461698": { "compartment": "compartment_12045", "id": "reaction_10461698", "reactome": "R-DME-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10461695", "catalyst" ] ], "additional_components": [ "Q9VIF2", "FBgn0032923", "Q9VIE9", "FBgn0263050", "species_74016" ] }, "reaction_10461713": { "compartment": "compartment_876", "id": "reaction_10461713", "reactome": "R-DME-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10461710", "catalyst" ] ], "additional_components": [ "species_74016", "Q9VXH3", "FBgn0003416" ] }, "reaction_10461681": { "compartment": "compartment_876", "id": "reaction_10461681", "reactome": "R-DME-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10461676", "catalyst" ] ], "additional_components": [ "FBgn0023508" ] }, "reaction_10461472": { "compartment": "compartment_70101", "id": "reaction_10461472", "reactome": "R-DME-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114520" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10461469", "catalyst" ] ], "additional_components": [ "species_74016", "Q7KV26", "FBgn0283680", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VL83", "FBgn0032147" ] }, "reaction_10465533": { "compartment": "compartment_70101", "id": "reaction_10465533", "reactome": "R-DME-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10446639" ], "products": [ "species_10440860" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10484665": { "compartment": "compartment_70101", "id": "reaction_10484665", "reactome": "R-DME-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10484662", "catalyst" ] ], "additional_components": [ "Q9VMP9", "FBgn0031717" ] }, "reaction_10481369": { "compartment": "compartment_70101", "id": "reaction_10481369", "reactome": "R-DME-6798335", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800" ], "products": [ "species_6798337" ], "modifiers": [ [ "species_10481366", "catalyst" ] ], "additional_components": [ "Q9VAN7", "FBgn0014869", "Q8T8W6", "FBgn0038957", "Q9VGB6", "FBgn0011270" ] }, "reaction_10429145": { "compartment": "compartment_70101", "id": "reaction_10429145", "reactome": "R-DME-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10429142", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q9VWH7", "FBgn0027621" ] }, "reaction_10427841": { "compartment": "compartment_70101", "id": "reaction_10427841", "reactome": "R-DME-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10427838", "catalyst" ] ], "additional_components": [ "Q9VWH7", "FBgn0027621" ] }, "reaction_10428045": { "compartment": "compartment_70101", "id": "reaction_10428045", "reactome": "R-DME-70471", "name": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29512" ], "modifiers": [ [ "species_10428042", "catalyst" ] ], "additional_components": [ "P52029", "FBgn0003074" ] }, "reaction_10428013": { "compartment": "compartment_70101", "id": "reaction_10428013", "reactome": "R-DME-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10428010", "catalyst" ] ], "additional_components": [ "P29613", "FBgn0086355" ] }, "reaction_10429003": { "compartment": "compartment_70101", "id": "reaction_10429003", "reactome": "R-DME-71660", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29356", "species_29492" ], "modifiers": [ [ "species_10428103", "catalyst" ] ], "additional_components": [ "species_29926", "P15007", "FBgn0000579" ] }, "reaction_10429001": { "compartment": "compartment_70101", "id": "reaction_10429001", "reactome": "R-DME-71654", "name": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29728" ], "products": [ "species_30485" ], "modifiers": [ [ "species_10428883", "catalyst" ] ], "additional_components": [ "Q9VAN7", "FBgn0014869" ] }, "reaction_10428902": { "compartment": "compartment_70101", "id": "reaction_10428902", "reactome": "R-DME-71496", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014" ], "products": [ "species_29578", "species_75970" ], "modifiers": [ [ "species_10428897", "catalyst" ] ], "additional_components": [ "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064" ] }, "reaction_10427973": { "compartment": "compartment_70101", "id": "reaction_10427973", "reactome": "R-DME-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10427970", "catalyst" ] ], "additional_components": [ "Q7JYW9", "FBgn0001187", "Q9W330", "FBgn0001186", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710" ] }, "reaction_10429157": { "compartment": "compartment_70101", "id": "reaction_10429157", "reactome": "R-DME-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10428087", "catalyst" ] ], "additional_components": [ "species_29926", "Q01604", "FBgn0250906" ] }, "reaction_10495131": { "compartment": "compartment_70101", "id": "reaction_10495131", "reactome": "R-DME-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29800" ], "products": [ "species_70106", "species_8955759", "species_29728" ], "modifiers": [ [ "species_10427859", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z9V3", "FBgn0033969", "A1Z7P1", "FBgn0033377" ] }, "reaction_10428035": { "compartment": "compartment_70101", "id": "reaction_10428035", "reactome": "R-DME-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_30014", "species_29370" ], "modifiers": [ [ "species_10428032", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_76190", "inhibitor" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "P52034", "FBgn0003071" ] }, "reaction_10428003": { "compartment": "compartment_70101", "id": "reaction_10428003", "reactome": "R-DME-70449", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_29578", "species_29360" ], "products": [ "species_70106", "species_29800", "species_73473" ], "modifiers": [ [ "species_10428000", "catalyst" ] ], "additional_components": [ "P07486", "FBgn0001091", "Q7JY07", "FBgn0034173", "P07487", "FBgn0001092" ] }, "reaction_10429058": { "compartment": "compartment_70101", "id": "reaction_10429058", "reactome": "R-DME-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10429055", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_29358", "inhibitor" ], [ "species_30389", "inhibitor" ] ], "additional_components": [ "Q9VNZ9", "FBgn0037115", "Q9VFG4", "FBgn0038258", "Q9VVH0", "FBgn0036723", "Q9VD23", "FBgn0038952", "Q9VQH0", "FBgn0031462", "O62619", "FBgn0267385", "species_29926", "species_74126" ] }, "reaction_10437795": { "compartment": "compartment_13231", "id": "reaction_10437795", "reactome": "R-DME-170825", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437793" ], "products": [ "species_10427948" ], "modifiers": [], "additional_components": [ "Q9W330", "FBgn0001186", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710", "Q7JYW9", "FBgn0001187", "Q7JYW9", "FBgn0001187", "Q9W330", "FBgn0001186", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710" ] }, "reaction_10453164": { "compartment": "compartment_70101", "id": "reaction_10453164", "reactome": "R-DME-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10453161", "catalyst" ] ], "additional_components": [ "FBgn0286506" ] }, "reaction_10450486": { "compartment": "compartment_70101", "id": "reaction_10450486", "reactome": "R-DME-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10450481", "catalyst" ] ], "additional_components": [ "FBgn0036300" ] }, "reaction_10447638": { "compartment": "compartment_876", "id": "reaction_10447638", "reactome": "R-DME-419002", "name": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447632", "species_10442033", "species_10447634", "species_10447624" ], "products": [ "species_10447636" ], "modifiers": [], "additional_components": [ "P18824", "arm", "FBgn0262018", "FBgn0260799", "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q7PLI0", "FBgn0260799", "Q9VJB6", "FBgn0262018", "P18824", "arm" ] }, "reaction_10447616": { "compartment": "compartment_204883", "id": "reaction_10447616", "reactome": "R-DME-419001", "name": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442033", "species_140648" ], "products": [ "species_10447614" ], "modifiers": [], "additional_components": [ "FBgn0262018", "Q9VJB6", "FBgn0262018" ] }, "reaction_10449511": { "compartment": "compartment_70101", "id": "reaction_10449511", "reactome": "R-DME-432909", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443378", "species_10441643" ], "products": [ "species_10449509" ], "modifiers": [], "additional_components": [ "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "FBgn0013733", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657" ] }, "reaction_10449527": { "compartment": "compartment_984", "id": "reaction_10449527", "reactome": "R-DME-432956", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449523", "species_10449519" ], "products": [ "species_10449525" ], "modifiers": [], "additional_components": [ "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10450422": { "compartment": "compartment_984", "id": "reaction_10450422", "reactome": "R-DME-446089", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443411", "species_10450420" ], "products": [ "species_10449519" ], "modifiers": [], "additional_components": [ "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10450418": { "compartment": "compartment_70101", "id": "reaction_10450418", "reactome": "R-DME-446083", "name": "CD151 interacts with BP180 and the integrin alpha 6 subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449525", "species_10450414" ], "products": [ "species_10450416" ], "modifiers": [], "additional_components": [ "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "FBgn0043550", "Q8IQK9", "FBgn0043550", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10449180": { "compartment": "compartment_70101", "id": "reaction_10449180", "reactome": "R-DME-430341", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449176", "species_10449164" ], "products": [ "species_10449178" ], "modifiers": [], "additional_components": [ "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688", "FBgn0011642", "Q9N675", "FBgn0011642", "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688" ] }, "reaction_10450586": { "compartment": "compartment_70101", "id": "reaction_10450586", "reactome": "R-DME-446391", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450580", "species_10450582", "species_10449503" ], "products": [ "species_10450584" ], "modifiers": [], "additional_components": [ "FBgn0028427", "Q9V400", "FBgn0028427", "Q8INQ9", "FBgn0020249" ] }, "reaction_10449507": { "compartment": "compartment_70101", "id": "reaction_10449507", "reactome": "R-DME-432897", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441029", "species_10449503" ], "products": [ "species_10449505" ], "modifiers": [], "additional_components": [ "FBgn0004657", "FBgn0028427", "Q9V400", "FBgn0028427", "P11584", "FBgn0004657" ] }, "reaction_10450563": { "compartment": "compartment_70101", "id": "reaction_10450563", "reactome": "R-DME-446322", "name": "PARVA associates with Paxillin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450559", "species_10438879" ], "products": [ "species_10450561" ], "modifiers": [], "additional_components": [ "FBgn0052528", "FBgn0041789", "Q9VWD0", "FBgn0052528", "Q2PDT4", "FBgn0041789" ] }, "reaction_10450567": { "compartment": "compartment_70101", "id": "reaction_10450567", "reactome": "R-DME-446364", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448617", "species_10449164" ], "products": [ "species_10450565" ], "modifiers": [], "additional_components": [ "FBgn0011642", "Q9N675", "FBgn0011642", "Q8T4F7", "ena" ] }, "reaction_10449188": { "compartment": "compartment_70101", "id": "reaction_10449188", "reactome": "R-DME-430347", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449184", "species_10449131", "species_10449164" ], "products": [ "species_10449186" ], "modifiers": [], "additional_components": [ "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "FBgn0014141", "FBgn0011642", "Q9N675", "FBgn0011642", "Q9VEN1", "FBgn0014141", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592" ] }, "reaction_10449515": { "compartment": "compartment_70101", "id": "reaction_10449515", "reactome": "R-DME-432946", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449141", "species_10442520" ], "products": [ "species_10449513" ], "modifiers": [], "additional_components": [ "FBgn0052528", "FBgn0015803", "A8DZ19", "FBgn0015803", "Q9VWD0", "FBgn0052528" ] }, "reaction_10449145": { "compartment": "compartment_70101", "id": "reaction_10449145", "reactome": "R-DME-430308", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449136", "species_10449141" ], "products": [ "species_10449143" ], "modifiers": [], "additional_components": [ "FBgn0000667", "FBgn0052528", "Q9VWD0", "FBgn0052528", "P18091", "FBgn0000667" ] }, "reaction_10449159": { "compartment": "compartment_70101", "id": "reaction_10449159", "reactome": "R-DME-430311", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449155", "species_10449150" ], "products": [ "species_10449157" ], "modifiers": [], "additional_components": [ "FBgn0020249", "FBgn0028546", "Q9V428", "FBgn0028546", "Q8INQ9", "FBgn0020249" ] }, "reaction_10450576": { "compartment": "compartment_70101", "id": "reaction_10450576", "reactome": "R-DME-446372", "name": "Association of PARVA with TESK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450572", "species_10450559" ], "products": [ "species_10450574" ], "modifiers": [], "additional_components": [ "FBgn0004876", "FBgn0052528", "Q9VWD0", "FBgn0052528", "Q9VE06", "FBgn0004876" ] }, "reaction_10444555": { "compartment": "compartment_876", "id": "reaction_10444555", "reactome": "R-DME-373732", "name": "Nephrin trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444454" ], "products": [ "species_10444456" ], "modifiers": [], "additional_components": [ "FBgn0024189", "Q0E9F2", "FBgn0024189" ] }, "reaction_10451625": { "compartment": "compartment_876", "id": "reaction_10451625", "reactome": "R-DME-451757", "name": "Heterodimerization of nephrin and KIRREL2, KIRREL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451621", "species_10444456" ], "products": [ "species_10451623" ], "modifiers": [], "additional_components": [ "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "A0A023GPK8", "FBgn0051774", "Q0E9F2", "FBgn0024189", "Q0E9F2", "FBgn0024189", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "A0A023GPK8", "FBgn0051774" ] }, "reaction_10495542": { "compartment": "compartment_876", "id": "reaction_10495542", "reactome": "R-DME-8981534", "name": "Nephrin dimer:KIRREL binds FYN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444480", "species_10444516" ], "products": [ "species_10444577" ], "modifiers": [], "additional_components": [ "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "FBgn0262733", "P00528", "FBgn0262733", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189" ] }, "reaction_10444566": { "compartment": "compartment_876", "id": "reaction_10444566", "reactome": "R-DME-373734", "name": "Nephrin interacts with Podocin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444528", "species_10444562" ], "products": [ "species_10444564" ], "modifiers": [], "additional_components": [ "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733", "Q9VZA4", "FBgn0260657", "Q9VZA4", "FBgn0260657", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733" ] }, "reaction_10444580": { "compartment": "compartment_876", "id": "reaction_10444580", "reactome": "R-DME-373747", "name": "Phosphorylation of nephrin by FYN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444577", "species_113592" ], "products": [ "species_10444528", "species_29370" ], "modifiers": [ [ "species_10444577", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189" ] }, "reaction_10444532": { "compartment": "compartment_876", "id": "reaction_10444532", "reactome": "R-DME-373724", "name": "Nephrin binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444528", "species_10444486" ], "products": [ "species_10444530" ], "modifiers": [], "additional_components": [ "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733", "Q9VPU1", "dock", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733" ] }, "reaction_10444482": { "compartment": "compartment_876", "id": "reaction_10444482", "reactome": "R-DME-373714", "name": "Cis-Heterodimerization of nephrin and KIRREL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444456", "species_10444478" ], "products": [ "species_10444480" ], "modifiers": [], "additional_components": [ "Q0E9F2", "FBgn0024189", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189" ] }, "reaction_10484751": { "compartment": "compartment_70101", "id": "reaction_10484751", "reactome": "R-DME-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484729", "species_71284" ], "products": [ "species_10484736", "species_71285" ], "modifiers": [ [ "species_10484748", "catalyst" ] ], "additional_components": [ "Q9VPH7", "FBgn0036974", "Q9VK85", "FBgn0020443", "species_29438", "Q9VPH7", "FBgn0036974", "Q9VK85", "FBgn0020443", "species_29438", "Q9VP65", "FBgn0037061", "Q9VQF8", "FBgn0031454" ] }, "reaction_10469966": { "compartment": "compartment_70101", "id": "reaction_10469966", "reactome": "R-DME-4608854", "name": "SMURF1/2 are recruited to the DVL2:PARD6A complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469940", "species_10437960" ], "products": [ "species_10469961" ], "modifiers": [], "additional_components": [ "O97111", "FBgn0026192", "P51140", "phospho-dsh", "FBgn0029006", "Q9V853", "FBgn0029006", "O97111", "FBgn0026192", "P51140", "phospho-dsh" ] }, "reaction_10469964": { "compartment": "compartment_70101", "id": "reaction_10469964", "reactome": "R-DME-4608852", "name": "SMURF1/2 ubiquitinates PRICKLE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10469951" ], "products": [ "species_10469959" ], "modifiers": [ [ "species_10469961", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9U1I1", "FBgn0263934", "A1Z6W3", "PK", "Q9U1I1", "FBgn0263934", "A1Z6W3", "PK", "Q9V853", "FBgn0029006", "O97111", "FBgn0026192", "P51140", "phospho-dsh" ] }, "reaction_10470337": { "compartment": "compartment_876", "id": "reaction_10470337", "reactome": "R-DME-5099886", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470333", "species_10468078" ], "products": [ "species_10470335" ], "modifiers": [], "additional_components": [ "Q9VVX3", "FZ2", "FBgn0010194", "P28466", "FBgn0010194", "Q9VVX3", "FZ2" ] }, "reaction_10469968": { "compartment": "compartment_70101", "id": "reaction_10469968", "reactome": "R-DME-4608855", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469959" ], "products": [], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9U1I1", "FBgn0263934", "A1Z6W3", "PK", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10456021": { "compartment": "compartment_20699", "id": "reaction_10456021", "reactome": "R-DME-977228", "name": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_10454862" ], "products": [ "species_10456019", "species_727810" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "FBgn0035050" ] }, "reaction_10456000": { "compartment": "compartment_17963", "id": "reaction_10456000", "reactome": "R-DME-977071", "name": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454561", "species_727815" ], "products": [ "species_727810", "species_10455998" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "FBgn0035050" ] }, "reaction_10463326": { "compartment": "compartment_984", "id": "reaction_10463326", "reactome": "R-DME-2022399", "name": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10444709" ], "products": [ "species_10463316" ], "modifiers": [ [ "species_10463323", "catalyst" ] ], "additional_components": [ "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "Q9VFX0", "FBgn0038135" ] }, "reaction_10463254": { "compartment": "compartment_984", "id": "reaction_10463254", "reactome": "R-DME-2022398", "name": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463066" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463251", "catalyst" ] ], "additional_components": [ "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10497644": { "compartment": "compartment_984", "id": "reaction_10497644", "reactome": "R-DME-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10478126", "catalyst" ] ], "additional_components": [ "P23654", "FBgn0004108" ] }, "reaction_10497585": { "compartment": "compartment_984", "id": "reaction_10497585", "reactome": "R-DME-9614933", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464707", "species_9614913" ], "products": [ "species_10464710" ], "modifiers": [], "additional_components": [ "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10463500": { "compartment": "compartment_984", "id": "reaction_10463500", "reactome": "R-DME-2022412", "name": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463388" ], "products": [ "species_10463198" ], "modifiers": [ [ "species_10463497", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q7K485", "FBgn0029093", "Q9VQ13", "FBgn0051926", "A1Z9Q9", "FBgn0033933", "Q9VQ12", "FBgn0053128", "Q9VQ11", "FBgn0051928", "Q9VLK3", "FBgn0032049", "Q9VKP7", "FBgn0032303", "Q9VKP6", "FBgn0032304", "Q9VEK4", "FBgn0038506", "Q9W5G3", "FBgn0011822", "Q9VEK3", "FBgn0038507", "Q9VQ14", "FBgn0053128" ] }, "reaction_10463467": { "compartment": "compartment_984", "id": "reaction_10463467", "reactome": "R-DME-2022405", "name": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10444709" ], "modifiers": [ [ "species_10463251", "catalyst" ], [ "species_188972", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10463464": { "compartment": "compartment_984", "id": "reaction_10463464", "reactome": "R-DME-2022403", "name": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463388" ], "products": [ "species_10463198" ], "modifiers": [ [ "species_10463461", "catalyst" ], [ "species_10463461", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VKP7", "FBgn0032303", "Q9VQ12", "FBgn0053128", "Q9W5G3", "FBgn0011822", "Q7K485", "FBgn0029093", "Q9VKP6", "FBgn0032304", "Q9VQ11", "FBgn0051928", "Q9VQ14", "FBgn0053128", "A1Z9Q9", "FBgn0033933", "Q9VEK4", "FBgn0038506", "Q9VLK3", "FBgn0032049", "Q9VQ13", "FBgn0051926", "Q9VEK3", "FBgn0038507", "Q9VHG4", "FBgn0037671", "Q9VKP7", "FBgn0032303", "Q9VQ12", "FBgn0053128", "Q9W5G3", "FBgn0011822", "Q7K485", "FBgn0029093", "Q9VKP6", "FBgn0032304", "Q9VQ11", "FBgn0051928", "Q9VQ14", "FBgn0053128", "A1Z9Q9", "FBgn0033933", "Q9VEK4", "FBgn0038506", "Q9VLK3", "FBgn0032049", "Q9VQ13", "FBgn0051926", "Q9VEK3", "FBgn0038507", "Q9VHG4", "FBgn0037671" ] }, "reaction_10464744": { "compartment": "compartment_984", "id": "reaction_10464744", "reactome": "R-DME-2065357", "name": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463388" ], "products": [ "species_10463198" ], "modifiers": [ [ "species_10464741", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VEK3", "FBgn0038507", "Q9VQ14", "FBgn0053128", "Q7K485", "FBgn0029093", "Q9VQ13", "FBgn0051926", "A1Z9Q9", "FBgn0033933", "Q9VQ12", "FBgn0053128", "Q9VQ11", "FBgn0051928", "Q9VLK3", "FBgn0032049", "Q9VKP7", "FBgn0032303", "Q9VKP6", "FBgn0032304", "Q9VEK4", "FBgn0038506", "Q9W5G3", "FBgn0011822", "Q9VHG4", "FBgn0037671" ] }, "reaction_10464712": { "compartment": "compartment_984", "id": "reaction_10464712", "reactome": "R-DME-2065355", "name": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10444709" ], "modifiers": [ [ "species_10464707", "catalyst" ], [ "species_188972", "catalyst" ], [ "species_10464710", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10463237": { "compartment": "compartment_984", "id": "reaction_10463237", "reactome": "R-DME-2022396", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463133", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "FBgn0031081" ] }, "reaction_10463235": { "compartment": "compartment_984", "id": "reaction_10463235", "reactome": "R-DME-2022379", "name": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10444709" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463230", "catalyst" ] ], "additional_components": [ "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "Q8SXX2", "FBgn0032536", "Q9W0Z1", "FBgn0035076", "Q10714", "FBgn0012037", "Q9VLJ6", "FBgn0016122", "A1Z7M8", "FBgn0033366", "Q9VJV2", "FBgn0032535" ] }, "reaction_10463233": { "compartment": "compartment_984", "id": "reaction_10463233", "reactome": "R-DME-2022378", "name": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10463066" ], "modifiers": [ [ "species_10463230", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "Q8SXX2", "FBgn0032536", "Q9W0Z1", "FBgn0035076", "Q10714", "FBgn0012037", "Q9VLJ6", "FBgn0016122", "A1Z7M8", "FBgn0033366", "Q9VJV2", "FBgn0032535" ] }, "reaction_10464257": { "compartment": "compartment_984", "id": "reaction_10464257", "reactome": "R-DME-2028294", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10463066" ], "modifiers": [ [ "species_10464254", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "Q961J8", "FBgn0035781", "Q9VRZ3", "FBgn0035718", "Q9VX86", "FBgn0030815", "Q7JYV3", "FBgn0033774", "Q9VLZ2", "FBgn0031929", "Q9VS80", "FBgn0035791", "Q0E9F9", "FBgn0033241", "Q9VLZ1", "FBgn0031930", "Q9VS67", "FBgn0035780", "M9PEV1", "FBgn0035776", "Q9VL87", "FBgn0032143", "Q9VS66", "FBgn0035779", "Q9W478", "FBgn0029804", "Q9VL86", "FBgn0032144", "Q9VS65", "FBgn0052379", "Q9W477", "FBgn0259149", "Q9VCM8", "FBgn0039073", "Q9VS64", "FBgn0035777", "Q9W475", "FBgn0029807" ] }, "reaction_10463136": { "compartment": "compartment_984", "id": "reaction_10463136", "reactome": "R-DME-2022368", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463066" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463133", "catalyst" ] ], "additional_components": [ "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "FBgn0031081" ] }, "reaction_209224": { "compartment": "compartment_70101", "id": "reaction_209224", "reactome": "R-DME-209224", "name": "SLMB binds to and ubiquitinates phosphorylated CI", "reversible": "false", "notes": "Phosphorylated Cubitus Interruptus (CI) is now recognised by Slimb (SLMB), which is part of the SCF (Skp1, Cdc53, and F-box) ubiquitin ligase complex. CI associates with SLMB via its phosphorylated residues and is then ubiquitinated by the SCF ubiquitin ligase complex.", "reactants": [ "species_206204", "species_206766", "species_206788" ], "products": [ "species_207011" ], "modifiers": [ [ "species_207002", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209278": { "compartment": "compartment_70101", "id": "reaction_209278", "reactome": "R-DME-209278", "name": "Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex", "reversible": "false", "notes": "Ubiquitinated and phosphorylated Cubitus Interruptus (CI) is processed by the proteasome complex resulting in a truncated product, CI75, with a C-terminus somewhere between residues 650-700 (Aza-Blanc et al., 1997) or 611-760 (Methot and Basler, 1999). It is thought that the zinc-finger domain and C-terminal simple sequences arrest proteasome digestion from the C-terminus. Some CI is likely to be fully proteolysed by the proteasome.", "reactants": [ "species_207011" ], "products": [ "species_206204", "species_206171", "species_206788", "species_206900" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_10475099": { "compartment": "compartment_70101", "id": "reaction_10475099", "reactome": "R-DME-5654647", "name": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475094", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475096": { "compartment": "compartment_876", "id": "reaction_10475096", "reactome": "R-DME-5654646", "name": "Activated FGFR3:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475085" ], "products": [ "species_10475094" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475073": { "compartment": "compartment_70101", "id": "reaction_10475073", "reactome": "R-DME-5654625", "name": "Activated FGFR3 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465477", "species_10474909" ], "products": [ "species_10475071" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475088": { "compartment": "compartment_70101", "id": "reaction_10475088", "reactome": "R-DME-5654634", "name": "Activated FGFR3 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475071" ], "products": [ "species_29370", "species_10475085" ], "modifiers": [ [ "species_10475071", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475069": { "compartment": "compartment_70101", "id": "reaction_10475069", "reactome": "R-DME-5654623", "name": "Activated FGFR3 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474997", "species_10465477" ], "products": [ "species_10475067" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474925": { "compartment": "compartment_876", "id": "reaction_10474925", "reactome": "R-DME-5654408", "name": "Activated FGFR3 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474920" ], "products": [ "species_29370", "species_10465479" ], "modifiers": [ [ "species_10474920", "catalyst" ], [ "species_10474923", "inhibitor" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474939": { "compartment": "compartment_70101", "id": "reaction_10474939", "reactome": "R-DME-5654416", "name": "Activated FGFR3:pFRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474932", "species_10431797" ], "products": [ "species_10474934" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475083": { "compartment": "compartment_876", "id": "reaction_10475083", "reactome": "R-DME-5654631", "name": "Activated FGFR3 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475078" ], "products": [ "species_29370", "species_10475080" ], "modifiers": [ [ "species_10475078", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474937": { "compartment": "compartment_70101", "id": "reaction_10474937", "reactome": "R-DME-5654413", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474934", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10493208": { "compartment": "compartment_70101", "id": "reaction_10493208", "reactome": "R-DME-8941628", "name": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475080", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475076": { "compartment": "compartment_876", "id": "reaction_10475076", "reactome": "R-DME-5654628", "name": "Activated FGFR3 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475067" ], "products": [ "species_10474930", "species_29370" ], "modifiers": [ [ "species_10475067", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474928": { "compartment": "compartment_70101", "id": "reaction_10474928", "reactome": "R-DME-5654409", "name": "Activated FGFR3 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465477", "species_10474873" ], "products": [ "species_10474920" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474855": { "compartment": "compartment_876", "id": "reaction_10474855", "reactome": "R-DME-5654224", "name": "Activated FGFR3 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10465477", "species_10439290" ], "products": [ "species_10474850" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0003416", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_179838" ] }, "reaction_10474822": { "compartment": "compartment_876", "id": "reaction_10474822", "reactome": "R-DME-5654148", "name": "p-4Y-PLCG1 dissociates from activated FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474820" ], "products": [ "species_10465477", "species_10441915" ], "modifiers": [], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0003416" ] }, "reaction_10474853": { "compartment": "compartment_70101", "id": "reaction_10474853", "reactome": "R-DME-5654222", "name": "Activated FGFR3 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474850", "species_113592" ], "products": [ "species_10474820", "species_29370" ], "modifiers": [ [ "species_10474850", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_179838", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_179838" ] }, "reaction_10475180": { "compartment": "compartment_70101", "id": "reaction_10475180", "reactome": "R-DME-5654709", "name": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465509", "catalyst" ] ], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475177": { "compartment": "compartment_70101", "id": "reaction_10475177", "reactome": "R-DME-5654705", "name": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465483", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475092": { "compartment": "compartment_70101", "id": "reaction_10475092", "reactome": "R-DME-5654641", "name": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465505", "species_10438945" ], "products": [ "species_10465507" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475090": { "compartment": "compartment_70101", "id": "reaction_10475090", "reactome": "R-DME-5654637", "name": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465479" ], "products": [ "species_10465481" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10488437": { "compartment": "compartment_17963", "id": "reaction_10488437", "reactome": "R-DME-8851619", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10488432" ], "products": [ "species_205687", "species_10488434" ], "modifiers": [ [ "species_10454602", "catalyst" ] ], "additional_components": [ "FBgn0014135", "FBgn0014135", "FBgn0034025" ] }, "reaction_10488439": { "compartment": "compartment_17963", "id": "reaction_10488439", "reactome": "R-DME-8851632", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488434" ], "products": [ "species_10433476" ], "modifiers": [], "additional_components": [ "FBgn0014135", "FBgn0014135" ] }, "reaction_10439768": { "compartment": "compartment_876", "id": "reaction_10439768", "reactome": "R-DME-190388", "name": "Autocatalytic phosphorylation of FGFR3c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439729", "species_113592" ], "products": [ "species_29370", "species_10433592" ], "modifiers": [ [ "species_10439729", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439731": { "compartment": "compartment_984", "id": "reaction_10439731", "reactome": "R-DME-190261", "name": "FGFR3c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433467", "species_10439725", "species_190915" ], "products": [ "species_10439729" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439743": { "compartment": "compartment_984", "id": "reaction_10439743", "reactome": "R-DME-190263", "name": "FGFR3b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439737", "species_190915", "species_10433471" ], "products": [ "species_10439741" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10439765": { "compartment": "compartment_876", "id": "reaction_10439765", "reactome": "R-DME-190385", "name": "Autocatalytic phosphorylation of FGFR3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439741" ], "products": [ "species_29370", "species_10433573" ], "modifiers": [ [ "species_10439741", "catalyst" ] ], "additional_components": [ "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "species_190915", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474991": { "compartment": "compartment_70101", "id": "reaction_10474991", "reactome": "R-DME-5654565", "name": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474920" ], "products": [ "species_29370", "species_10474923" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "P40417", "FBgn0003256" ] }, "reaction_10475192": { "compartment": "compartment_70101", "id": "reaction_10475192", "reactome": "R-DME-5654730", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465505", "species_10439154" ], "products": [ "species_10475150" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475155": { "compartment": "compartment_70101", "id": "reaction_10475155", "reactome": "R-DME-5654679", "name": "CBL ubiquitinates FRS2 and FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10475150" ], "products": [ "species_10475152" ], "modifiers": [ [ "species_10475150", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10439771": { "compartment": "compartment_876", "id": "reaction_10439771", "reactome": "R-DME-190408", "name": "Autocatalytic phosphorylation of FGFR2b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439717", "species_113592" ], "products": [ "species_29370", "species_10433531" ], "modifiers": [ [ "species_10439717", "catalyst" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439719": { "compartment": "compartment_876", "id": "reaction_10439719", "reactome": "R-DME-190260", "name": "FGFR2b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433429", "species_10439670", "species_190915" ], "products": [ "species_10439717" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0014135", "FBgn0285896", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439774": { "compartment": "compartment_876", "id": "reaction_10439774", "reactome": "R-DME-190413", "name": "Autocatalytic phosphorylation of FGFR2c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439703" ], "products": [ "species_10433553", "species_29370" ], "modifiers": [ [ "species_10439703", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896" ] }, "reaction_10439705": { "compartment": "compartment_876", "id": "reaction_10439705", "reactome": "R-DME-190258", "name": "FGFR2c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439691", "species_10433467", "species_190915" ], "products": [ "species_10439703" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0285896", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896" ] }, "reaction_10475065": { "compartment": "compartment_876", "id": "reaction_10475065", "reactome": "R-DME-5654620", "name": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465499" ], "products": [ "species_10465501" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475174": { "compartment": "compartment_70101", "id": "reaction_10475174", "reactome": "R-DME-5654701", "name": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465475", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475171": { "compartment": "compartment_70101", "id": "reaction_10475171", "reactome": "R-DME-5654697", "name": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465503", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475056": { "compartment": "compartment_876", "id": "reaction_10475056", "reactome": "R-DME-5654612", "name": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465471" ], "products": [ "species_10465473" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475054": { "compartment": "compartment_876", "id": "reaction_10475054", "reactome": "R-DME-5654607", "name": "Activated FGFR2 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475049" ], "products": [ "species_29370", "species_10475051" ], "modifiers": [ [ "species_10475049", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474893": { "compartment": "compartment_70101", "id": "reaction_10474893", "reactome": "R-DME-5654399", "name": "Activated FGFR2 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474873", "species_10465469" ], "products": [ "species_10474875" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042" ] }, "reaction_10493202": { "compartment": "compartment_70101", "id": "reaction_10493202", "reactome": "R-DME-8941618", "name": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475051", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474890": { "compartment": "compartment_876", "id": "reaction_10474890", "reactome": "R-DME-5654397", "name": "Activated FGFR2 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474875" ], "products": [ "species_29370", "species_10465471" ], "modifiers": [ [ "species_10474875", "catalyst" ], [ "species_10474888", "inhibitor" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475063": { "compartment": "compartment_70101", "id": "reaction_10475063", "reactome": "R-DME-5654618", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475058", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475060": { "compartment": "compartment_70101", "id": "reaction_10475060", "reactome": "R-DME-5654615", "name": "Activated FGFR2:pFRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475047" ], "products": [ "species_10475058" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474907": { "compartment": "compartment_70101", "id": "reaction_10474907", "reactome": "R-DME-5654402", "name": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474904", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474918": { "compartment": "compartment_70101", "id": "reaction_10474918", "reactome": "R-DME-5654407", "name": "Activated FGFR2 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474911" ], "products": [ "species_29370", "species_10474902" ], "modifiers": [ [ "species_10474911", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474915": { "compartment": "compartment_876", "id": "reaction_10474915", "reactome": "R-DME-5654406", "name": "Activated FGFR2:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10474902" ], "products": [ "species_10474904" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474913": { "compartment": "compartment_70101", "id": "reaction_10474913", "reactome": "R-DME-5654404", "name": "Activated FGFR2 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474909", "species_10465469" ], "products": [ "species_10474911" ], "modifiers": [], "additional_components": [ "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474840": { "compartment": "compartment_876", "id": "reaction_10474840", "reactome": "R-DME-5654159", "name": "Activated FGFR2 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10439290", "species_10465469" ], "products": [ "species_10474813" ], "modifiers": [], "additional_components": [ "FBgn0003416", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474838": { "compartment": "compartment_876", "id": "reaction_10474838", "reactome": "R-DME-5654157", "name": "p-4Y-PLCG1 dissociates from activated FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474815" ], "products": [ "species_10441915", "species_10465469" ], "modifiers": [], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "FBgn0003416", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474818": { "compartment": "compartment_70101", "id": "reaction_10474818", "reactome": "R-DME-5654147", "name": "Activated FGFR2 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474813" ], "products": [ "species_29370", "species_10474815" ], "modifiers": [ [ "species_10474813", "catalyst" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_179838", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474989": { "compartment": "compartment_70101", "id": "reaction_10474989", "reactome": "R-DME-5654562", "name": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474875" ], "products": [ "species_29370", "species_10474888" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "P40417", "FBgn0003256" ] }, "reaction_10475148": { "compartment": "compartment_70101", "id": "reaction_10475148", "reactome": "R-DME-5654677", "name": "CBL ubiquitinates FRS2 and FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475143", "species_10426987" ], "products": [ "species_10475145" ], "modifiers": [ [ "species_10475143", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10475190": { "compartment": "compartment_70101", "id": "reaction_10475190", "reactome": "R-DME-5654729", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439154", "species_10465499" ], "products": [ "species_10475143" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10485933": { "compartment": "compartment_7660", "id": "reaction_10485933", "reactome": "R-DME-6803527", "name": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485901", "species_10485929", "species_10485927", "species_10485894", "species_10429340", "species_10485922" ], "products": [ "species_10485931" ], "modifiers": [], "additional_components": [ "Q9VGH5", "FBgn0259139", "Q9W0D6", "FBgn0035235", "M9NFQ7", "FBgn0052062", "FBgn0023441", "FBgn0023441", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "FBgn0267790", "A8JPX0", "FBgn0085383", "E1JIZ9", "FBgn0085391", "Q8IMX4", "FBgn0005649", "A8JPX0", "FBgn0085383", "E1JIZ9", "FBgn0085391", "Q8IMX4", "FBgn0005649", "Q9VHC7", "FBgn0267790", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9BJZ5", "FBgn0023441", "Q9VGH5", "FBgn0259139", "Q9W0D6", "FBgn0035235", "M9NFQ7", "FBgn0052062" ] }, "reaction_10474976": { "compartment": "compartment_876", "id": "reaction_10474976", "reactome": "R-DME-5654511", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433429", "species_10474972", "species_190915" ], "products": [ "species_10474974" ], "modifiers": [], "additional_components": [ "FBgn0014135", "Q9I7U4", "FBgn0086906", "species_190915", "Q9I7U4", "FBgn0086906", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474987": { "compartment": "compartment_70101", "id": "reaction_10474987", "reactome": "R-DME-5654560", "name": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474982" ], "products": [ "species_29370", "species_10474984" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "P40417", "FBgn0003256" ] }, "reaction_10475141": { "compartment": "compartment_70101", "id": "reaction_10475141", "reactome": "R-DME-5654673", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439154", "species_10465493" ], "products": [ "species_10475134" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10475139": { "compartment": "compartment_70101", "id": "reaction_10475139", "reactome": "R-DME-5654672", "name": "CBL ubiquitinates FRS2 and FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10475134" ], "products": [ "species_10475136" ], "modifiers": [ [ "species_10475134", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10474978": { "compartment": "compartment_876", "id": "reaction_10474978", "reactome": "R-DME-5654514", "name": "KAL1 binds FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439681", "species_10439672" ], "products": [ "species_10439683" ], "modifiers": [], "additional_components": [ "FBgn0039155", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VCC7", "FBgn0039155" ] }, "reaction_10439666": { "compartment": "compartment_984", "id": "reaction_10439666", "reactome": "R-DME-190245", "name": "FGFR1b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433429", "species_10439660", "species_190915" ], "products": [ "species_10439664" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439777": { "compartment": "compartment_876", "id": "reaction_10439777", "reactome": "R-DME-190427", "name": "Autocatalytic phosphorylation of FGFR1b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439664", "species_113592" ], "products": [ "species_29370", "species_10433465" ], "modifiers": [ [ "species_10439664", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "species_190915", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439687": { "compartment": "compartment_984", "id": "reaction_10439687", "reactome": "R-DME-190256", "name": "FGFR1c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439672", "species_10433467", "species_190915" ], "products": [ "species_10439676" ], "modifiers": [ [ "species_190915", "catalyst" ], [ "species_10439685", "catalyst" ], [ "species_10439683", "inhibitor" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VCC7", "FBgn0039155", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VCC7", "FBgn0039155" ] }, "reaction_10439780": { "compartment": "compartment_876", "id": "reaction_10439780", "reactome": "R-DME-190429", "name": "Autocatalytic phosphorylation of FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439676" ], "products": [ "species_29370", "species_10433484" ], "modifiers": [ [ "species_10439676", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474980": { "compartment": "compartment_984", "id": "reaction_10474980", "reactome": "R-DME-5654515", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439681", "species_190915" ], "products": [ "species_10439685" ], "modifiers": [], "additional_components": [ "FBgn0039155", "species_190915", "Q9VCC7", "FBgn0039155" ] }, "reaction_10439759": { "compartment": "compartment_984", "id": "reaction_10439759", "reactome": "R-DME-190268", "name": "FGFR1c binds to Klotho-bound FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439672", "species_190915", "species_10433503" ], "products": [ "species_10439757" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10439920": { "compartment": "compartment_876", "id": "reaction_10439920", "reactome": "R-DME-191062", "name": "Autocatalytic phosphorylation of Klotho-bound FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439757" ], "products": [ "species_10433505", "species_29370" ], "modifiers": [ [ "species_10439757", "catalyst" ] ], "additional_components": [ "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474846": { "compartment": "compartment_876", "id": "reaction_10474846", "reactome": "R-DME-5654167", "name": "Activated FGFR1 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10465461", "species_10439290" ], "products": [ "species_10474824" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0003416", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_179838" ] }, "reaction_10474829": { "compartment": "compartment_70101", "id": "reaction_10474829", "reactome": "R-DME-5654149", "name": "Activated FGFR1 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474824" ], "products": [ "species_29370", "species_10474826" ], "modifiers": [ [ "species_10474824", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_179838", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_179838" ] }, "reaction_10474844": { "compartment": "compartment_876", "id": "reaction_10474844", "reactome": "R-DME-5654165", "name": "p-4Y-PLCG1 dissociates from activated FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474826" ], "products": [ "species_10465461", "species_10441915" ], "modifiers": [], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0003416" ] }, "reaction_10475309": { "compartment": "compartment_876", "id": "reaction_10475309", "reactome": "R-DME-5656064", "name": "Activated FGFR1 binds FLRT1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475301", "species_10465461" ], "products": [ "species_10475307" ], "modifiers": [], "additional_components": [ "FBgn0028872", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "M9MSI4", "FBgn0028872", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475018": { "compartment": "compartment_70101", "id": "reaction_10475018", "reactome": "R-DME-5654586", "name": "Activated FGFR1:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474866", "species_10431797" ], "products": [ "species_10474868" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10493205": { "compartment": "compartment_70101", "id": "reaction_10493205", "reactome": "R-DME-8941623", "name": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475022", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475001": { "compartment": "compartment_70101", "id": "reaction_10475001", "reactome": "R-DME-5654571", "name": "Activated FGFR1 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465461", "species_10474997" ], "products": [ "species_10474999" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10474871": { "compartment": "compartment_70101", "id": "reaction_10474871", "reactome": "R-DME-5654392", "name": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474868", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10474995": { "compartment": "compartment_70101", "id": "reaction_10474995", "reactome": "R-DME-5654569", "name": "Activated FGFR1 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465461", "species_10474873" ], "products": [ "species_10474982" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475011": { "compartment": "compartment_876", "id": "reaction_10475011", "reactome": "R-DME-5654578", "name": "Activated FGFR1 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474999" ], "products": [ "species_10474864", "species_29370" ], "modifiers": [ [ "species_10474999", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475025": { "compartment": "compartment_876", "id": "reaction_10475025", "reactome": "R-DME-5654587", "name": "Activated FGFR1:p-FRS phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475020" ], "products": [ "species_29370", "species_10475022" ], "modifiers": [ [ "species_10475020", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475008": { "compartment": "compartment_876", "id": "reaction_10475008", "reactome": "R-DME-5654575", "name": "Activated FGFR1 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474982" ], "products": [ "species_29370", "species_10465463" ], "modifiers": [ [ "species_10474982", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475165": { "compartment": "compartment_70101", "id": "reaction_10475165", "reactome": "R-DME-5654690", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465467", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475029": { "compartment": "compartment_70101", "id": "reaction_10475029", "reactome": "R-DME-5654594", "name": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465493" ], "products": [ "species_10465495" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475027": { "compartment": "compartment_70101", "id": "reaction_10475027", "reactome": "R-DME-5654592", "name": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465463" ], "products": [ "species_10465465" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475168": { "compartment": "compartment_70101", "id": "reaction_10475168", "reactome": "R-DME-5654692", "name": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465497", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10459327": { "compartment": "compartment_876", "id": "reaction_10459327", "reactome": "R-DME-1470009", "name": "Phosphorylation of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10459159" ], "products": [ "species_29370", "species_10459324" ], "modifiers": [ [ "species_10459159", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop" ] }, "reaction_10498528": { "compartment": "compartment_876", "id": "reaction_10498528", "reactome": "R-DME-9681375", "name": "KIT binds ripretinib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442600", "species_9674322" ], "products": [ "species_10498526" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10498434": { "compartment": "compartment_876", "id": "reaction_10498434", "reactome": "R-DME-9669854", "name": "KIT binds type II TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9669722", "species_10442600" ], "products": [ "species_10498432" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10459164": { "compartment": "compartment_876", "id": "reaction_10459164", "reactome": "R-DME-1433471", "name": "Activation of RAS by p-KIT bound SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10442628", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10459161": { "compartment": "compartment_876", "id": "reaction_10459161", "reactome": "R-DME-1433456", "name": "Recruitment of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445861", "species_10459141" ], "products": [ "species_10459159" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop" ] }, "reaction_10459128": { "compartment": "compartment_70101", "id": "reaction_10459128", "reactome": "R-DME-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10459125", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "species_179838", "Q9NHV9", "FBgn0040068" ] }, "reaction_10459144": { "compartment": "compartment_876", "id": "reaction_10459144", "reactome": "R-DME-1433418", "name": "Phosphorylation of JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459136", "species_113592" ], "products": [ "species_29370", "species_10459141" ], "modifiers": [ [ "species_10459136", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop" ] }, "reaction_10459335": { "compartment": "compartment_876", "id": "reaction_10459335", "reactome": "R-DME-1470012", "name": "Disassociation and translocation of STATs to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459329" ], "products": [ "species_10458565", "species_10459141" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "Q24151", "Stat92E", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop" ] }, "reaction_10459157": { "compartment": "compartment_876", "id": "reaction_10459157", "reactome": "R-DME-1433423", "name": "PTP-RO interacts with p-c-Kit complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459153", "species_10442600" ], "products": [ "species_10459155" ], "modifiers": [], "additional_components": [ "Q9VJ95", "FBgn0267486", "A1ZAB3", "FBgn0034085", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ95", "FBgn0267486", "A1ZAB3", "FBgn0034085" ] }, "reaction_10459331": { "compartment": "compartment_876", "id": "reaction_10459331", "reactome": "R-DME-1470010", "name": "Dimerization of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459324" ], "products": [ "species_10459329" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop", "Q24151", "Stat92E", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop" ] }, "reaction_10459179": { "compartment": "compartment_876", "id": "reaction_10459179", "reactome": "R-DME-1433508", "name": "PKC alpha interacts with and phosphorylates KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434436", "species_113592", "species_10442600" ], "products": [ "species_29370", "species_10459176" ], "modifiers": [ [ "species_10434436", "catalyst" ] ], "additional_components": [ "FBgn0003091", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "P05130", "FBgn0003091", "FBgn0003091" ] }, "reaction_10442632": { "compartment": "compartment_876", "id": "reaction_10442632", "reactome": "R-DME-205244", "name": "Recruitment of CBL to KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442628", "species_10439032" ], "products": [ "species_10442630" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "FBgn0020224", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10458441": { "compartment": "compartment_70101", "id": "reaction_10458441", "reactome": "R-DME-1250383", "name": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10458438", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9V3C8", "FBgn0015296" ] }, "reaction_10458591": { "compartment": "compartment_7660", "id": "reaction_10458591", "reactome": "R-DME-1254386", "name": "ERBB4s80 forms a complex with estrogen receptor ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458515", "species_10458587" ], "products": [ "species_10458589" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "species_374146", "Q8WS79", "FBgn0035849", "species_374146", "Q8WS79", "FBgn0035849", "P04412", "FBgn0003731" ] }, "reaction_10458540": { "compartment": "compartment_70101", "id": "reaction_10458540", "reactome": "R-DME-1253343", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466", "species_10458536" ], "products": [ "species_10458538" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "FBgn0031972", "Q9VLU5", "FBgn0031972", "P04412", "FBgn0003731" ] }, "reaction_10458571": { "compartment": "compartment_70101", "id": "reaction_10458571", "reactome": "R-DME-1254291", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466", "species_10458559" ], "products": [ "species_10458561" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "Q24151", "Stat92E", "Q24151", "Stat92E", "P04412", "FBgn0003731" ] }, "reaction_10458554": { "compartment": "compartment_70101", "id": "reaction_10458554", "reactome": "R-DME-1254251", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544", "species_10458466" ], "products": [ "species_10458546" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q45VV3", "yki" ] }, "reaction_10458505": { "compartment": "compartment_70101", "id": "reaction_10458505", "reactome": "R-DME-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458456" ], "products": [ "species_10458466" ], "modifiers": [ [ "species_10458502", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9VQG2", "FBgn0031458", "Q86BE9", "FBgn0053198", "O02194", "FBgn0284421", "Q9VC27", "FBgn0039234" ] }, "reaction_10458569": { "compartment": "compartment_70101", "id": "reaction_10458569", "reactome": "R-DME-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458561" ], "products": [ "species_10458567" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "P04412", "FBgn0003731", "Q24151", "Stat92E", "P04412", "FBgn0003731" ] }, "reaction_10458552": { "compartment": "compartment_70101", "id": "reaction_10458552", "reactome": "R-DME-1254248", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458546" ], "products": [ "species_10458550" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "Q45VV3", "yki", "Q45VV3", "yki", "P04412", "FBgn0003731" ] }, "reaction_10458519": { "compartment": "compartment_70101", "id": "reaction_10458519", "reactome": "R-DME-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466" ], "products": [ "species_10458515" ], "modifiers": [ [ "species_10458517", "inhibitor" ] ], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731", "P00528", "FBgn0262733", "P04412", "FBgn0003731" ] }, "reaction_10458583": { "compartment": "compartment_70101", "id": "reaction_10458583", "reactome": "R-DME-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466" ], "products": [ "species_10458581" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731" ] }, "reaction_10462454": { "compartment": "compartment_70101", "id": "reaction_10462454", "reactome": "R-DME-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10462447" ], "products": [ "species_10462451" ], "modifiers": [ [ "species_10462447", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174" ] }, "reaction_10458531": { "compartment": "compartment_876", "id": "reaction_10458531", "reactome": "R-DME-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456500", "species_10458522" ], "products": [ "species_10458524" ], "modifiers": [], "additional_components": [ "FBgn0003557", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10458529": { "compartment": "compartment_70101", "id": "reaction_10458529", "reactome": "R-DME-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10458524" ], "products": [ "species_10458526" ], "modifiers": [ [ "species_10458524", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10462449": { "compartment": "compartment_70101", "id": "reaction_10462449", "reactome": "R-DME-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456484", "species_10458460" ], "products": [ "species_10462447" ], "modifiers": [], "additional_components": [ "FBgn0259174", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174" ] }, "reaction_10497518": { "compartment": "compartment_876", "id": "reaction_10497518", "reactome": "R-DME-9612219", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466", "species_10444503" ], "products": [ "species_10458517" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "FBgn0262733", "P00528", "FBgn0262733", "P04412", "FBgn0003731" ] }, "reaction_10476599": { "compartment": "compartment_70101", "id": "reaction_10476599", "reactome": "R-DME-5685366", "name": "GRB2-1:SOS1 binds p-Y-SHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475810", "species_10431797" ], "products": [ "species_10475816" ], "modifiers": [], "additional_components": [ "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9V3C8", "FBgn0015296" ] }, "reaction_10437918": { "compartment": "compartment_876", "id": "reaction_10437918", "reactome": "R-DME-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10437914" ], "products": [ "species_10437916" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "FBgn0026376", "M9PCE9", "FBgn0026376", "species_29438", "P08646", "RAS85D" ] }, "reaction_10497488": { "compartment": "compartment_70101", "id": "reaction_10497488", "reactome": "R-DME-9610166", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458636" ], "products": [ "species_10440935" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10497474": { "compartment": "compartment_74700", "id": "reaction_10497474", "reactome": "R-DME-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10497463" ], "products": [ "species_10497467", "species_29370" ], "modifiers": [ [ "species_10497463", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1" ] }, "reaction_10497478": { "compartment": "compartment_70101", "id": "reaction_10497478", "reactome": "R-DME-9610154", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497476" ], "products": [ "species_10475873", "species_10497461", "species_10433771" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "FBgn0003256" ] }, "reaction_10497465": { "compartment": "compartment_74700", "id": "reaction_10497465", "reactome": "R-DME-9610152", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475906", "species_10497461", "species_10433742" ], "products": [ "species_10497463" ], "modifiers": [], "additional_components": [ "Q24324", "phospho-Dsor1", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "FBgn0003256", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1" ] }, "reaction_10497481": { "compartment": "compartment_70101", "id": "reaction_10497481", "reactome": "R-DME-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497467", "species_113592" ], "products": [ "species_29370", "species_10497476" ], "modifiers": [ [ "species_10497467", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1" ] }, "reaction_10475989": { "compartment": "compartment_70101", "id": "reaction_10475989", "reactome": "R-DME-5674385", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433771" ], "products": [ "species_10458636" ], "modifiers": [], "additional_components": [ "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10497486": { "compartment": "compartment_74700", "id": "reaction_10497486", "reactome": "R-DME-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497483", "species_113592" ], "products": [ "species_29370", "species_10497461" ], "modifiers": [ [ "species_10497483", "catalyst" ] ], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta" ] }, "reaction_10438835": { "compartment": "compartment_984", "id": "reaction_10438835", "reactome": "R-DME-177479", "name": "Axonal transport of NGF:Trk complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438827" ], "products": [ "species_10438827" ], "modifiers": [ [ "species_10438832", "catalyst" ] ], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "FBgn0033687" ] }, "reaction_10440762": { "compartment": "compartment_947587", "id": "reaction_10440762", "reactome": "R-DME-198266", "name": "PI3K produces PIP3 and other phosphatidyl inositides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10440759", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9XTN2", "chico" ] }, "reaction_10441962": { "compartment": "compartment_876", "id": "reaction_10441962", "reactome": "R-DME-202692", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10434902" ], "products": [ "species_10441960" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_179838" ] }, "reaction_10431807": { "compartment": "compartment_70101", "id": "reaction_10431807", "reactome": "R-DME-74736", "name": "GRB2-1:SOS1 binds p-IRS1,p-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10431801" ], "products": [ "species_10431805" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10433706": { "compartment": "compartment_876", "id": "reaction_10433706", "reactome": "R-DME-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10433702" ], "products": [ "species_10433704" ], "modifiers": [], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10433715": { "compartment": "compartment_70101", "id": "reaction_10433715", "reactome": "R-DME-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433696", "species_113592" ], "products": [ "species_10433712", "species_29370" ], "modifiers": [ [ "species_10433704", "catalyst" ] ], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "Q8INB9", "phospho-Akt1", "species_179838", "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10433698": { "compartment": "compartment_876", "id": "reaction_10433698", "reactome": "R-DME-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10433694" ], "products": [ "species_10433696", "species_10433688" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "Q9V3Z1", "FBgn0028978", "Q8INB9", "phospho-Akt1", "species_179838", "FBgn0028978" ] }, "reaction_10433683": { "compartment": "compartment_70101", "id": "reaction_10433683", "reactome": "R-DME-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10433680", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9XTN2", "chico", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10431824": { "compartment": "compartment_70101", "id": "reaction_10431824", "reactome": "R-DME-74737", "name": "p-Y-IRS1,p-Y-IRS2 bind PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431801", "species_10431820" ], "products": [ "species_10431822" ], "modifiers": [], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9XTN2", "chico" ] }, "reaction_10431786": { "compartment": "compartment_876", "id": "reaction_10431786", "reactome": "R-DME-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431784" ], "products": [ "species_10431589" ], "modifiers": [], "additional_components": [ "P09208", "InR", "P09208", "InR" ] }, "reaction_10431768": { "compartment": "compartment_17940", "id": "reaction_10431768", "reactome": "R-DME-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10431765", "catalyst" ] ], "additional_components": [ "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q7JR49", "FBgn0262515" ] }, "reaction_10471490": { "compartment": "compartment_171062", "id": "reaction_10471490", "reactome": "R-DME-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431763", "species_10431758" ], "products": [ "species_10431765" ], "modifiers": [], "additional_components": [ "FBgn0262515", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q7JR49", "FBgn0262515" ] }, "reaction_10433749": { "compartment": "compartment_70101", "id": "reaction_10433749", "reactome": "R-DME-109823", "name": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10431805" ], "products": [ "species_10433747", "species_29370" ], "modifiers": [ [ "species_10433740", "catalyst" ] ], "additional_components": [ "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0003256" ] }, "reaction_10476611": { "compartment": "compartment_70101", "id": "reaction_10476611", "reactome": "R-DME-5686315", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433747" ], "products": [ "species_10433733", "species_10431801" ], "modifiers": [], "additional_components": [ "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10433745": { "compartment": "compartment_70101", "id": "reaction_10433745", "reactome": "R-DME-109822", "name": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10431832" ], "products": [ "species_29370", "species_10433735" ], "modifiers": [ [ "species_10433740", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0003256" ] }, "reaction_10476609": { "compartment": "compartment_70101", "id": "reaction_10476609", "reactome": "R-DME-5686074", "name": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433735" ], "products": [ "species_10433733", "species_10431830" ], "modifiers": [], "additional_components": [ "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296" ] }, "reaction_10433725": { "compartment": "compartment_70101", "id": "reaction_10433725", "reactome": "R-DME-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431795", "species_10431791" ], "products": [ "species_10431797" ], "modifiers": [], "additional_components": [ "FBgn0004638", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10431834": { "compartment": "compartment_70101", "id": "reaction_10431834", "reactome": "R-DME-74746", "name": "GRB2-1:SOS1 binds p-Y427-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10431830" ], "products": [ "species_10431832" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10446431": { "compartment": "compartment_70101", "id": "reaction_10446431", "reactome": "R-DME-389083", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10446424" ], "products": [ "species_29370", "species_10446426" ], "modifiers": [ [ "species_10446424", "catalyst" ], [ "species_10446429", "inhibitor" ] ], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964" ] }, "reaction_10489777": { "compartment": "compartment_984", "id": "reaction_10489777", "reactome": "R-DME-8865276", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446192" ], "products": [ "species_10489771", "species_10439284", "species_10439338" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "FBgn0030964", "Q9VWP6", "FBgn0030964", "FBgn0030964", "FBgn0004509" ] }, "reaction_10446204": { "compartment": "compartment_20699", "id": "reaction_10446204", "reactome": "R-DME-382053", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446186" ], "products": [ "species_10446202" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964" ] }, "reaction_10439340": { "compartment": "compartment_984", "id": "reaction_10439340", "reactome": "R-DME-186785", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439336" ], "products": [ "species_10439338", "species_10439276" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "FBgn0030964", "Q9VWP6", "FBgn0030964", "FBgn0004509" ] }, "reaction_10439324": { "compartment": "compartment_876", "id": "reaction_10439324", "reactome": "R-DME-186773", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439286", "species_10439308" ], "products": [ "species_10439318" ], "modifiers": [ [ "species_10439320", "inhibitor" ], [ "species_10439322", "inhibitor" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10498453": { "compartment": "compartment_876", "id": "reaction_10498453", "reactome": "R-DME-9674093", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9674075", "species_10446424" ], "products": [ "species_10446429" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964" ] }, "reaction_10446441": { "compartment": "compartment_70101", "id": "reaction_10446441", "reactome": "R-DME-389086", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446436", "species_113592" ], "products": [ "species_29370", "species_10446438" ], "modifiers": [ [ "species_10446436", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10498455": { "compartment": "compartment_876", "id": "reaction_10498455", "reactome": "R-DME-9674095", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9674079", "species_10439308" ], "products": [ "species_10439320" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10439359": { "compartment": "compartment_70101", "id": "reaction_10439359", "reactome": "R-DME-186800", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10439328", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10439294": { "compartment": "compartment_876", "id": "reaction_10439294", "reactome": "R-DME-186765", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439288", "species_10439290" ], "products": [ "species_10439292" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "FBgn0003416", "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10439356": { "compartment": "compartment_70101", "id": "reaction_10439356", "reactome": "R-DME-186798", "name": "GAP binds to PDGF-beta receptors only", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439344", "species_10439352" ], "products": [ "species_10439354" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "FBgn0003969", "Q8IR23", "FBgn0003969", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10445851": { "compartment": "compartment_70101", "id": "reaction_10445851", "reactome": "R-DME-380780", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439361", "species_113592" ], "products": [ "species_29370", "species_10445848" ], "modifiers": [ [ "species_10439361", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P00528", "FBgn0262733" ] }, "reaction_10446232": { "compartment": "compartment_70101", "id": "reaction_10446232", "reactome": "R-DME-382058", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444486", "species_10439288" ], "products": [ "species_10446230" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10446164": { "compartment": "compartment_70101", "id": "reaction_10446164", "reactome": "R-DME-382052", "name": "p130Cas and C3G bind PDGFR bound Crk", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446160", "species_10446150", "species_10446155" ], "products": [ "species_10446162" ], "modifiers": [], "additional_components": [ "FBgn0259228", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9XYM0", "FBgn0024811", "FBgn0035101", "A4IJ58", "FBgn0035101", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9XYM0", "FBgn0024811", "O77086", "FBgn0259228" ] }, "reaction_10459917": { "compartment": "compartment_876", "id": "reaction_10459917", "reactome": "R-DME-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439292" ], "products": [ "species_29370", "species_10459912" ], "modifiers": [ [ "species_10439292", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10445867": { "compartment": "compartment_70101", "id": "reaction_10445867", "reactome": "R-DME-380782", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439288", "species_10445855" ], "products": [ "species_10445865" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q24151", "Stat92E", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10459914": { "compartment": "compartment_876", "id": "reaction_10459914", "reactome": "R-DME-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459912" ], "products": [ "species_10439288", "species_10441915" ], "modifiers": [], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "FBgn0003416" ] }, "reaction_10439370": { "compartment": "compartment_70101", "id": "reaction_10439370", "reactome": "R-DME-186834", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10439365", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10439367": { "compartment": "compartment_70101", "id": "reaction_10439367", "reactome": "R-DME-186826", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10439288" ], "products": [ "species_10439365" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10446214": { "compartment": "compartment_70101", "id": "reaction_10446214", "reactome": "R-DME-382056", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446146", "species_10439288" ], "products": [ "species_10446150" ], "modifiers": [], "additional_components": [ "FBgn0024811", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9XYM0", "FBgn0024811" ] }, "reaction_10439363": { "compartment": "compartment_876", "id": "reaction_10439363", "reactome": "R-DME-186819", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438881", "species_10439288" ], "products": [ "species_10439361" ], "modifiers": [], "additional_components": [ "FBgn0262733", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P00528", "FBgn0262733" ] }, "reaction_10439330": { "compartment": "compartment_70101", "id": "reaction_10439330", "reactome": "R-DME-186780", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439288", "species_10431820" ], "products": [ "species_10439328" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10446228": { "compartment": "compartment_984", "id": "reaction_10446228", "reactome": "R-DME-382057", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446216" ], "products": [ "species_10446226" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964" ] }, "reaction_10439347": { "compartment": "compartment_70101", "id": "reaction_10439347", "reactome": "R-DME-186786", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439342" ], "products": [ "species_10439344", "species_29370" ], "modifiers": [ [ "species_10439342", "catalyst" ] ], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964" ] }, "reaction_10489775": { "compartment": "compartment_984", "id": "reaction_10489775", "reactome": "R-DME-8865275", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446190" ], "products": [ "species_10439282", "species_10489771" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964", "FBgn0030964", "FBgn0004509" ] }, "reaction_10479727": { "compartment": "compartment_70101", "id": "reaction_10479727", "reactome": "R-DME-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479721", "species_10475516" ], "products": [ "species_10479725" ], "modifiers": [], "additional_components": [ "Q9VG04", "FBgn0038110", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "Q9VG04", "FBgn0038110", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10479723": { "compartment": "compartment_70101", "id": "reaction_10479723", "reactome": "R-DME-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458352", "species_10479719" ], "products": [ "species_10479721" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0038110", "Q9VG04", "FBgn0038110", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10498279": { "compartment": "compartment_70101", "id": "reaction_10498279", "reactome": "R-DME-9652264", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9652360", "species_10462124" ], "products": [ "species_10462235" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573" ] }, "reaction_10462237": { "compartment": "compartment_876", "id": "reaction_10462237", "reactome": "R-DME-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462226", "species_113592" ], "products": [ "species_29370", "species_10458345" ], "modifiers": [ [ "species_10462226", "catalyst" ], [ "species_10462231", "inhibitor" ], [ "species_10462235", "inhibitor" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573" ] }, "reaction_10458911": { "compartment": "compartment_876", "id": "reaction_10458911", "reactome": "R-DME-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10458908", "catalyst" ] ], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10458913": { "compartment": "compartment_876", "id": "reaction_10458913", "reactome": "R-DME-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458352", "species_10438839" ], "products": [ "species_10458904" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10458920": { "compartment": "compartment_876", "id": "reaction_10458920", "reactome": "R-DME-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10458917", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10462245": { "compartment": "compartment_876", "id": "reaction_10462245", "reactome": "R-DME-1963586", "name": "SRC family kinases phosphorylate ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462226", "species_113592" ], "products": [ "species_29370", "species_10462221" ], "modifiers": [ [ "species_10444503", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0262733" ] }, "reaction_10458359": { "compartment": "compartment_876", "id": "reaction_10458359", "reactome": "R-DME-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458354", "species_113592" ], "products": [ "species_10458356", "species_29370" ], "modifiers": [ [ "species_10458354", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10491995": { "compartment": "compartment_70101", "id": "reaction_10491995", "reactome": "R-DME-8934446", "name": "Activated PKC phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10476601" ], "products": [ "species_10491981", "species_29370" ], "modifiers": [ [ "species_10491992", "catalyst" ] ], "additional_components": [ "FBgn0015296", "FBgn0015296", "species_74016", "P05130", "FBgn0003091", "species_114519", "species_33625" ] }, "reaction_10489700": { "compartment": "compartment_876", "id": "reaction_10489700", "reactome": "R-DME-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10489685" ], "products": [ "species_29372", "species_10489697" ], "modifiers": [ [ "species_10489685", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10462217": { "compartment": "compartment_876", "id": "reaction_10462217", "reactome": "R-DME-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458352", "species_10462213" ], "products": [ "species_10462215" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0262081", "Q8INJ8", "FBgn0262081", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10462134": { "compartment": "compartment_70101", "id": "reaction_10462134", "reactome": "R-DME-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10462124" ], "products": [ "species_10462131" ], "modifiers": [ [ "species_10456634", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "FBgn0039632" ] }, "reaction_10458958": { "compartment": "compartment_70101", "id": "reaction_10458958", "reactome": "R-DME-1358792", "name": "RNF41 ubiquitinates activated ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458953", "species_10426987" ], "products": [ "species_10458955", "species_10456701" ], "modifiers": [ [ "species_10458953", "catalyst" ] ], "additional_components": [ "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649", "Q9VUV7", "FBgn0283649" ] }, "reaction_10458939": { "compartment": "compartment_70101", "id": "reaction_10458939", "reactome": "R-DME-1358790", "name": "RNF41 ubiquitinates ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458934", "species_10426987" ], "products": [ "species_10458936", "species_10456701" ], "modifiers": [ [ "species_10458934", "catalyst" ] ], "additional_components": [ "Q9VUV7", "FBgn0283649", "P04412", "FBgn0003731", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "FBgn0283649", "Q9VUV7", "FBgn0283649", "P04412", "FBgn0003731" ] }, "reaction_10458967": { "compartment": "compartment_70101", "id": "reaction_10458967", "reactome": "R-DME-1358801", "name": "ERBB3 binds RNF41 ubiquitin ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458281", "species_10456701" ], "products": [ "species_10458934" ], "modifiers": [], "additional_components": [ "FBgn0003731", "FBgn0283649", "Q9VUV7", "FBgn0283649", "P04412", "FBgn0003731" ] }, "reaction_10458949": { "compartment": "compartment_70101", "id": "reaction_10458949", "reactome": "R-DME-1358791", "name": "Phosphorylation of USP8 by P-AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458944", "species_113592" ], "products": [ "species_10458947", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0038862", "FBgn0038862" ] }, "reaction_10458965": { "compartment": "compartment_70101", "id": "reaction_10458965", "reactome": "R-DME-1358797", "name": "Ubiquitinated RNF41 binds P-USP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458929", "species_10458947" ], "products": [ "species_10458960" ], "modifiers": [], "additional_components": [ "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0038862", "Q9VDD8", "FBgn0038862", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10458932": { "compartment": "compartment_70101", "id": "reaction_10458932", "reactome": "R-DME-1358789", "name": "Self-ubiquitination of RNF41", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10456701" ], "products": [ "species_10458929" ], "modifiers": [ [ "species_10456701", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649" ] }, "reaction_10458963": { "compartment": "compartment_70101", "id": "reaction_10458963", "reactome": "R-DME-1358795", "name": "Deubiquitination of RNF41 by P-USP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458960" ], "products": [ "species_10458947", "species_10426987", "species_10456701" ], "modifiers": [ [ "species_10458960", "catalyst" ] ], "additional_components": [ "Q9VDD8", "FBgn0038862", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0038862", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649", "Q9VDD8", "FBgn0038862", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10462129": { "compartment": "compartment_70101", "id": "reaction_10462129", "reactome": "R-DME-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10462124" ], "products": [ "species_10462126" ], "modifiers": [ [ "species_10456460", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "FBgn0027052" ] }, "reaction_10462224": { "compartment": "compartment_876", "id": "reaction_10462224", "reactome": "R-DME-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10462221" ], "products": [ "species_29370", "species_10458350" ], "modifiers": [ [ "species_10462221", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10498464": { "compartment": "compartment_459", "id": "reaction_10498464", "reactome": "R-DME-9674531", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498460", "species_10438846" ], "products": [ "species_10498462" ], "modifiers": [], "additional_components": [ "FBgn0036460", "FBgn0003731", "P04412", "FBgn0003731", "M9NE98", "FBgn0036460" ] }, "reaction_10438959": { "compartment": "compartment_70101", "id": "reaction_10438959", "reactome": "R-DME-177934", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10438855" ], "products": [ "species_29370", "species_10438908" ], "modifiers": [ [ "species_10438855", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10439003": { "compartment": "compartment_984", "id": "reaction_10439003", "reactome": "R-DME-177942", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438851", "species_10438846" ], "products": [ "species_10438853" ], "modifiers": [ [ "species_10439001", "inhibitor" ] ], "additional_components": [ "FBgn0000119", "FBgn0003731", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0034083" ] }, "reaction_10438857": { "compartment": "compartment_876", "id": "reaction_10438857", "reactome": "R-DME-177922", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438853" ], "products": [ "species_10438855" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10443325": { "compartment": "compartment_876", "id": "reaction_10443325", "reactome": "R-DME-212713", "name": "Active PLC-gamma1 dissociates from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443320" ], "products": [ "species_10441915", "species_10438908" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VXH3", "FBgn0003416", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10443323": { "compartment": "compartment_70101", "id": "reaction_10443323", "reactome": "R-DME-212710", "name": "EGFR activates PLC-gamma1 by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443316", "species_113592" ], "products": [ "species_29370", "species_10443320" ], "modifiers": [ [ "species_10443316", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VXH3", "FBgn0003416", "Q9VXH3", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10443318": { "compartment": "compartment_876", "id": "reaction_10443318", "reactome": "R-DME-212706", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438908", "species_10441886" ], "products": [ "species_10443316" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0003416", "Q9VXH3", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10438943": { "compartment": "compartment_70101", "id": "reaction_10438943", "reactome": "R-DME-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10438937" ], "products": [ "species_29370", "species_10438910" ], "modifiers": [ [ "species_10438937", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438927": { "compartment": "compartment_70101", "id": "reaction_10438927", "reactome": "R-DME-177924", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438912", "species_29356" ], "products": [ "species_29372", "species_10438925" ], "modifiers": [ [ "species_10438912", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438841": { "compartment": "compartment_70101", "id": "reaction_10438841", "reactome": "R-DME-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433424", "species_10431791" ], "products": [ "species_10438839" ], "modifiers": [], "additional_components": [ "FBgn0016794", "FBgn0004638", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794" ] }, "reaction_10438969": { "compartment": "compartment_70101", "id": "reaction_10438969", "reactome": "R-DME-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438912", "species_29356" ], "products": [ "species_29372", "species_10438967" ], "modifiers": [ [ "species_10438912", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438996": { "compartment": "compartment_70101", "id": "reaction_10438996", "reactome": "R-DME-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438935", "species_10438908" ], "products": [ "species_10438937" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10439027": { "compartment": "compartment_70101", "id": "reaction_10439027", "reactome": "R-DME-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10438839" ], "products": [ "species_10438933" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438915": { "compartment": "compartment_70101", "id": "reaction_10438915", "reactome": "R-DME-177923", "name": "Sustained activation of SRC kinase by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10438877" ], "products": [ "species_29372", "species_10438883", "species_10438862" ], "modifiers": [ [ "species_10438912", "catalyst" ] ], "additional_components": [ "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q2PDT4", "FBgn0041789", "Q2PDT4", "FBgn0041789", "P00528", "FBgn0262733", "FBgn0262081", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438994": { "compartment": "compartment_70101", "id": "reaction_10438994", "reactome": "R-DME-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10438991", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10439199": { "compartment": "compartment_70101", "id": "reaction_10439199", "reactome": "R-DME-183089", "name": "CBL binds and ubiquitinates phosphorylated Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439111", "species_10426987", "species_10439039" ], "products": [ "species_10439174" ], "modifiers": [ [ "species_10439039", "catalyst" ] ], "additional_components": [ "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10439103": { "compartment": "compartment_70101", "id": "reaction_10439103", "reactome": "R-DME-182986", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439090", "species_10426987" ], "products": [ "species_10439100" ], "modifiers": [ [ "species_10439090", "catalyst" ] ], "additional_components": [ "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q8T390", "FBgn0038659", "Q9VS85", "FBgn0028582", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659" ] }, "reaction_10439197": { "compartment": "compartment_70101", "id": "reaction_10439197", "reactome": "R-DME-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439192", "species_10426987" ], "products": [ "species_10439185", "species_10439194" ], "modifiers": [ [ "species_10439192", "catalyst" ] ], "additional_components": [ "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10439164": { "compartment": "compartment_70101", "id": "reaction_10439164", "reactome": "R-DME-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10439132" ], "products": [ "species_10439156" ], "modifiers": [ [ "species_10439132", "catalyst" ], [ "species_10439162", "inhibitor" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "FBgn0267486" ] }, "reaction_10439130": { "compartment": "compartment_70101", "id": "reaction_10439130", "reactome": "R-DME-182993", "name": "Ubiquitination of stimulated EGFR (CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10439039" ], "products": [ "species_10439127" ], "modifiers": [ [ "species_10439039", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10439190": { "compartment": "compartment_70101", "id": "reaction_10439190", "reactome": "R-DME-183067", "name": "Localization of CBL:GRB2 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439179", "species_10438908" ], "products": [ "species_10439185" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439125": { "compartment": "compartment_876", "id": "reaction_10439125", "reactome": "R-DME-182990", "name": "Sprouty sequesters CBL away from active EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439090", "species_10439119" ], "products": [ "species_10439123" ], "modifiers": [], "additional_components": [ "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659", "FBgn0014388", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659" ] }, "reaction_10439188": { "compartment": "compartment_70101", "id": "reaction_10439188", "reactome": "R-DME-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439185", "species_113592" ], "products": [ "species_29370", "species_10439132" ], "modifiers": [ [ "species_10439185", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439152": { "compartment": "compartment_70101", "id": "reaction_10439152", "reactome": "R-DME-183002", "name": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439146", "species_10439148" ], "products": [ "species_10439150" ], "modifiers": [], "additional_components": [ "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10439183": { "compartment": "compartment_876", "id": "reaction_10439183", "reactome": "R-DME-183055", "name": "Binding of CBL to EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10438908" ], "products": [ "species_10439034" ], "modifiers": [], "additional_components": [ "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224" ] }, "reaction_10490064": { "compartment": "compartment_876", "id": "reaction_10490064", "reactome": "R-DME-8867041", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490059", "species_113592" ], "products": [ "species_10490061", "species_29370" ], "modifiers": [ [ "species_10490059", "catalyst" ] ], "additional_components": [ "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582" ] }, "reaction_10439181": { "compartment": "compartment_70101", "id": "reaction_10439181", "reactome": "R-DME-183052", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10431791" ], "products": [ "species_10439179" ], "modifiers": [], "additional_components": [ "FBgn0020224", "FBgn0004638", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439117": { "compartment": "compartment_876", "id": "reaction_10439117", "reactome": "R-DME-182988", "name": "Sprouty lures CBL away from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439109", "species_10439032" ], "products": [ "species_10439115" ], "modifiers": [], "additional_components": [ "FBgn0014388", "FBgn0020224", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388" ] }, "reaction_10490066": { "compartment": "compartment_876", "id": "reaction_10490066", "reactome": "R-DME-8867044", "name": "EGFR binds EPS15, EPN1, EPS15L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439047", "species_10439066", "species_10439068", "species_10439148", "species_179856" ], "products": [ "species_10490059" ], "modifiers": [], "additional_components": [ "FBgn0028582", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582" ] }, "reaction_10439177": { "compartment": "compartment_70101", "id": "reaction_10439177", "reactome": "R-DME-183051", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439170", "species_10426987" ], "products": [ "species_10439174" ], "modifiers": [ [ "species_10439170", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O44783", "FBgn0014388", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388" ] }, "reaction_10490074": { "compartment": "compartment_876", "id": "reaction_10490074", "reactome": "R-DME-8867047", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490061", "species_29356" ], "products": [ "species_29372", "species_10490059" ], "modifiers": [ [ "species_10490071", "catalyst" ] ], "additional_components": [ "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "FBgn0261985" ] }, "reaction_10439203": { "compartment": "compartment_70101", "id": "reaction_10439203", "reactome": "R-DME-183094", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10439146" ], "products": [ "species_10439201" ], "modifiers": [], "additional_components": [ "FBgn0020224", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439042": { "compartment": "compartment_70101", "id": "reaction_10439042", "reactome": "R-DME-182969", "name": "Phosphorylation of CBL (EGFR:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439034" ], "products": [ "species_29370", "species_10439039" ], "modifiers": [ [ "species_10439034", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224" ] }, "reaction_10438973": { "compartment": "compartment_70101", "id": "reaction_10438973", "reactome": "R-DME-177936", "name": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10438953" ], "products": [ "species_10438971" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10438956": { "compartment": "compartment_70101", "id": "reaction_10438956", "reactome": "R-DME-177933", "name": "SHC1 phosphorylation by phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438929", "species_113592" ], "products": [ "species_29370", "species_10438953" ], "modifiers": [ [ "species_10438929", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296" ] }, "reaction_10438931": { "compartment": "compartment_70101", "id": "reaction_10438931", "reactome": "R-DME-177925", "name": "SHC1 binds to the phosphorylated EGF receptor:ligand complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431840", "species_10438908" ], "products": [ "species_10438929" ], "modifiers": [], "additional_components": [ "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296" ] }, "reaction_10439009": { "compartment": "compartment_70101", "id": "reaction_10439009", "reactome": "R-DME-177945", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10438971", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10438978": { "compartment": "compartment_70101", "id": "reaction_10438978", "reactome": "R-DME-177937", "name": "Phosphorylation of EGFR by SRC kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10438855" ], "products": [ "species_29370", "species_10438908" ], "modifiers": [ [ "species_10438975", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0262733" ] }, "reaction_10439006": { "compartment": "compartment_70101", "id": "reaction_10439006", "reactome": "R-DME-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10438908" ], "products": [ "species_10438982" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10438985": { "compartment": "compartment_70101", "id": "reaction_10438985", "reactome": "R-DME-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10438982", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10486291": { "compartment": "compartment_7660", "id": "reaction_10486291", "reactome": "R-DME-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10486280" ], "products": [ "species_10427430", "species_10486289" ], "modifiers": [ [ "species_10467616", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0030366" ] }, "reaction_10486293": { "compartment": "compartment_7660", "id": "reaction_10486293", "reactome": "R-DME-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486289" ], "products": [ "species_10441147" ], "modifiers": [], "additional_components": [] }, "reaction_10486282": { "compartment": "compartment_70101", "id": "reaction_10486282", "reactome": "R-DME-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486276" ], "products": [ "species_10486280" ], "modifiers": [], "additional_components": [] }, "reaction_10486287": { "compartment": "compartment_70101", "id": "reaction_10486287", "reactome": "R-DME-6807106", "name": "PTEN undergoes monoubiquitination", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10441147" ], "products": [ "species_10486276" ], "modifiers": [ [ "species_10486284", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10433277": { "compartment": "compartment_7660", "id": "reaction_10433277", "reactome": "R-DME-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433273", "species_10429982" ], "products": [ "species_10433275" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10433287": { "compartment": "compartment_7660", "id": "reaction_10433287", "reactome": "R-DME-77592", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433283" ], "products": [ "species_10430001", "species_10430036", "species_10433285", "species_10430024", "species_112165" ], "modifiers": [], "additional_components": [ "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7KNF2", "FBgn0005648", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q7K4N3", "FBgn0022942", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q9V3L6", "FBgn0022943", "Q7KNF2", "FBgn0005648", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872" ] }, "reaction_10433281": { "compartment": "compartment_7660", "id": "reaction_10433281", "reactome": "R-DME-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430001", "species_10433275" ], "products": [ "species_10433279" ], "modifiers": [], "additional_components": [ "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867" ] }, "reaction_10461644": { "compartment": "compartment_17957", "id": "reaction_10461644", "reactome": "R-DME-1855200", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024002" ], "products": [ "species_113551", "species_2024016" ], "modifiers": [ [ "species_10461541", "catalyst" ] ], "additional_components": [ "FBgn0026061" ] }, "reaction_10461544": { "compartment": "compartment_17957", "id": "reaction_10461544", "reactome": "R-DME-1855163", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024008" ], "products": [ "species_113551", "species_2024012" ], "modifiers": [ [ "species_10461541", "catalyst" ] ], "additional_components": [ "FBgn0026061" ] }, "reaction_10461732": { "compartment": "compartment_17957", "id": "reaction_10461732", "reactome": "R-DME-1855225", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024018" ], "products": [ "species_113551", "species_2564836" ], "modifiers": [ [ "species_10461541", "catalyst" ] ], "additional_components": [ "FBgn0026061" ] }, "reaction_10473766": { "compartment": "compartment_876", "id": "reaction_10473766", "reactome": "R-DME-5623632", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473760", "species_10433704" ], "products": [ "species_10473764" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621", "Q9W0V1", "Pdk1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621" ] }, "reaction_10475670": { "compartment": "compartment_70101", "id": "reaction_10475670", "reactome": "R-DME-5671749", "name": "p-T774-PKN1 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475665", "species_113592" ], "products": [ "species_10431988", "species_29370", "species_10473769" ], "modifiers": [ [ "species_10475665", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "A1Z7T0", "FBgn0020621", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0020621", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "A1Z7T0", "FBgn0020621" ] }, "reaction_10432022": { "compartment": "compartment_70101", "id": "reaction_10432022", "reactome": "R-DME-75016", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432018", "species_10431988" ], "products": [ "species_10432020" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon" ] }, "reaction_10475685": { "compartment": "compartment_70101", "id": "reaction_10475685", "reactome": "R-DME-5671772", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475630", "species_10475678" ], "products": [ "species_10475683" ], "modifiers": [], "additional_components": [ "M9NEB2", "FBgn0005536", "P48462", "flw", "FBgn0032297", "Q9VKQ5", "FBgn0032297", "M9NEB2", "FBgn0005536", "P48462", "flw" ] }, "reaction_10475667": { "compartment": "compartment_70101", "id": "reaction_10475667", "reactome": "R-DME-5671737", "name": "p-T774-PKN1 binds CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473769", "species_10435503" ], "products": [ "species_10475665" ], "modifiers": [], "additional_components": [ "FBgn0020621", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "A1Z7T0", "FBgn0020621" ] }, "reaction_10473762": { "compartment": "compartment_876", "id": "reaction_10473762", "reactome": "R-DME-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473750", "species_10473758" ], "products": [ "species_10473760" ], "modifiers": [], "additional_components": [ "FBgn0020621", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621" ] }, "reaction_10473778": { "compartment": "compartment_70101", "id": "reaction_10473778", "reactome": "R-DME-5623667", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473764", "species_113592" ], "products": [ "species_29370", "species_10433704", "species_10473769", "species_10473758" ], "modifiers": [ [ "species_10473764", "catalyst" ] ], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621", "Q9W0V1", "Pdk1", "species_179838", "FBgn0020621", "P48148", "Rho1", "species_29438", "Q9W0V1", "Pdk1", "species_179838", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621" ] }, "reaction_10474173": { "compartment": "compartment_7660", "id": "reaction_10474173", "reactome": "R-DME-5625717", "name": "Phosphorylated PKN1 binds androgen receptor (AR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473330", "species_10473769" ], "products": [ "species_10474171" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849", "FBgn0020621", "A1Z7T0", "FBgn0020621", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849" ] }, "reaction_10474183": { "compartment": "compartment_7660", "id": "reaction_10474183", "reactome": "R-DME-5625745", "name": "PKN1 stimulates association of AR with NCOA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474177", "species_10440442" ], "products": [ "species_10474181" ], "modifiers": [], "additional_components": [ "A1Z7T0", "FBgn0020621", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "FBgn0041092", "A1Z7T0", "FBgn0020621", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "M9ND53", "FBgn0041092" ] }, "reaction_10474179": { "compartment": "compartment_70101", "id": "reaction_10474179", "reactome": "R-DME-5625738", "name": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474171" ], "products": [ "species_10474177" ], "modifiers": [], "additional_components": [ "A1Z7T0", "FBgn0020621", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849", "A1Z7T0", "FBgn0020621", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079" ] }, "reaction_10475681": { "compartment": "compartment_70101", "id": "reaction_10475681", "reactome": "R-DME-5671763", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475675" ], "products": [ "species_29370", "species_10475678" ], "modifiers": [ [ "species_10473769", "catalyst" ] ], "additional_components": [ "FBgn0032297", "FBgn0032297", "FBgn0020621" ] }, "reaction_10475533": { "compartment": "compartment_70101", "id": "reaction_10475533", "reactome": "R-DME-5665999", "name": "MKL1 translocates from cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475531" ], "products": [ "species_10469150" ], "modifiers": [], "additional_components": [ "FBgn0052296", "FBgn0052296" ] }, "reaction_10469116": { "compartment": "compartment_70101", "id": "reaction_10469116", "reactome": "R-DME-3858495", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469108", "species_10469112" ], "products": [ "species_10469114" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "M9MSM5", "FBgn0025641", "species_29926", "P48148", "Rho1", "species_29438", "species_29926", "P48148", "Rho1", "species_29438", "P51140", "phospho-dsh", "M9MSM5", "FBgn0025641" ] }, "reaction_10475529": { "compartment": "compartment_7660", "id": "reaction_10475529", "reactome": "R-DME-5665998", "name": "MKL1 binds SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475525", "species_10469150" ], "products": [ "species_10475527" ], "modifiers": [], "additional_components": [ "FBgn0004101", "FBgn0052296", "B7Z043", "FBgn0052296", "Q24535", "FBgn0004101" ] }, "reaction_10475542": { "compartment": "compartment_7660", "id": "reaction_10475542", "reactome": "R-DME-5666008", "name": "SCAI binds SRF:MKL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475538", "species_10475527" ], "products": [ "species_10475540" ], "modifiers": [], "additional_components": [ "FBgn0035677", "B7Z043", "FBgn0052296", "Q24535", "FBgn0004101", "B7Z043", "FBgn0052296", "Q24535", "FBgn0004101", "M9PER3", "FBgn0035677" ] }, "reaction_10475558": { "compartment": "compartment_70101", "id": "reaction_10475558", "reactome": "R-DME-5666104", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475552", "species_10440003" ], "products": [ "species_10475556" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "FBgn0262733", "P00528", "FBgn0262733", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202" ] }, "reaction_10469110": { "compartment": "compartment_70101", "id": "reaction_10469110", "reactome": "R-DME-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469106", "species_10441719" ], "products": [ "species_10469108" ], "modifiers": [], "additional_components": [ "FBgn0025641", "P51140", "phospho-dsh", "M9MSM5", "FBgn0025641" ] }, "reaction_10475554": { "compartment": "compartment_70101", "id": "reaction_10475554", "reactome": "R-DME-5666088", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475546", "species_10475550" ], "products": [ "species_10475552" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202" ] }, "reaction_10475457": { "compartment": "compartment_876", "id": "reaction_10475457", "reactome": "R-DME-5665727", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439139", "species_10475453" ], "products": [ "species_10475455" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "Q9VUC6", "FBgn0267795", "M9PE53", "FBgn0264272", "Q9VUC6", "FBgn0267795", "M9PE53", "FBgn0264272", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10475520": { "compartment": "compartment_70101", "id": "reaction_10475520", "reactome": "R-DME-5665989", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475514", "species_10434906" ], "products": [ "species_10475516" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202" ] }, "reaction_10464334": { "compartment": "compartment_70101", "id": "reaction_10464334", "reactome": "R-DME-2029460", "name": "PAK1 phosphorylates LIMK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447163" ], "products": [ "species_29370", "species_10447166" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "FBgn0283712", "FBgn0283712", "FBgn0267698" ] }, "reaction_10495682": { "compartment": "compartment_70101", "id": "reaction_10495682", "reactome": "R-DME-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446521", "species_10446509" ], "products": [ "species_10474308", "species_10446519" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "FBgn0267698" ] }, "reaction_10495684": { "compartment": "compartment_70101", "id": "reaction_10495684", "reactome": "R-DME-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446517", "species_10446509" ], "products": [ "species_10474306", "species_10446515" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "FBgn0267698" ] }, "reaction_10475643": { "compartment": "compartment_70101", "id": "reaction_10475643", "reactome": "R-DME-5669158", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_10464328" ], "products": [ "species_10475641" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "FBgn0086384", "Q24564", "FBgn0086384", "B7Z0W0", "FBgn0267698" ] }, "reaction_10464330": { "compartment": "compartment_70101", "id": "reaction_10464330", "reactome": "R-DME-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_10446509" ], "products": [ "species_10446525", "species_10446511" ], "modifiers": [ [ "species_10464328", "inhibitor" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698", "FBgn0086384" ] }, "reaction_10474313": { "compartment": "compartment_70101", "id": "reaction_10474313", "reactome": "R-DME-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474310" ], "products": [ "species_29370", "species_10447061", "species_10446509" ], "modifiers": [ [ "species_10474310", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME" ] }, "reaction_10475657": { "compartment": "compartment_70101", "id": "reaction_10475657", "reactome": "R-DME-5669250", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475647" ], "products": [ "species_10447061", "species_29370", "species_10475654" ], "modifiers": [ [ "species_10475647", "catalyst" ] ], "additional_components": [ "Q9VEN1", "FBgn0014141", "B7Z0W0", "FBgn0267698", "FBgn0267698", "Q9VEN1", "FBgn0014141", "Q9VEN1", "FBgn0014141", "B7Z0W0", "FBgn0267698" ] }, "reaction_10475622": { "compartment": "compartment_70101", "id": "reaction_10475622", "reactome": "R-DME-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475599" ], "products": [ "species_10475619", "species_29370" ], "modifiers": [ [ "species_10447065", "catalyst" ] ], "additional_components": [ "Q9VG88", "FBgn0053098", "P40423", "phospho-sqh", "P18432", "FBgn0002773", "Q9W4B1", "FBgn0085464", "Q9VQA5", "FBgn0031410", "P54357", "Mlc-c", "P06742", "FBgn0002772", "Q99323", "zip", "Q9W4B1", "FBgn0085464", "Q9VQA5", "FBgn0031410", "P54357", "Mlc-c", "P06742", "FBgn0002772", "Q99323", "zip", "Q9VG88", "FBgn0053098", "P40423", "phospho-sqh", "P18432", "FBgn0002773", "FBgn0267698" ] }, "reaction_10475637": { "compartment": "compartment_70101", "id": "reaction_10475637", "reactome": "R-DME-5668947", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475630" ], "products": [ "species_10475635", "species_29370" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "M9NEB2", "FBgn0005536", "P48462", "flw", "M9NEB2", "FBgn0005536", "P48462", "flw", "FBgn0267698" ] }, "reaction_10475649": { "compartment": "compartment_70101", "id": "reaction_10475649", "reactome": "R-DME-5669240", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447061", "species_10475645" ], "products": [ "species_10475647" ], "modifiers": [], "additional_components": [ "FBgn0267698", "Q9VEN1", "FBgn0014141", "Q9VEN1", "FBgn0014141", "B7Z0W0", "FBgn0267698" ] }, "reaction_10481326": { "compartment": "compartment_1222693", "id": "reaction_10481326", "reactome": "R-DME-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_1629751", "species_29370" ], "modifiers": [ [ "species_10481323", "catalyst" ] ], "additional_components": [ "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10464910": { "compartment": "compartment_876", "id": "reaction_10464910", "reactome": "R-DME-2130194", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464388", "species_113592" ], "products": [ "species_10464452", "species_29370" ], "modifiers": [ [ "species_10445197", "catalyst" ] ], "additional_components": [ "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "P40792", "RAC1_DROME", "species_29438", "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10464460": { "compartment": "compartment_70101", "id": "reaction_10464460", "reactome": "R-DME-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449184", "species_10464456" ], "products": [ "species_10464458" ], "modifiers": [], "additional_components": [ "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10464473": { "compartment": "compartment_70101", "id": "reaction_10464473", "reactome": "R-DME-2029469", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464452", "species_113592" ], "products": [ "species_29370", "species_10464428" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "P40417", "FBgn0003256" ] }, "reaction_10465367": { "compartment": "compartment_70101", "id": "reaction_10465367", "reactome": "R-DME-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464458" ], "products": [ "species_10464454", "species_10464494" ], "modifiers": [], "additional_components": [ "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_29370" ] }, "reaction_10464496": { "compartment": "compartment_70101", "id": "reaction_10464496", "reactome": "R-DME-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464494", "species_10442127" ], "products": [ "species_10461792" ], "modifiers": [], "additional_components": [ "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_29370", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046" ] }, "reaction_10475571": { "compartment": "compartment_70101", "id": "reaction_10475571", "reactome": "R-DME-5667008", "name": "RHOA:GTP binds RHPN1 or RHPN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434906", "species_10475565" ], "products": [ "species_10475569" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "FBgn0026374", "Q9XYY9", "FBgn0026374", "P48148", "Rho1", "species_29438" ] }, "reaction_10438409": { "compartment": "compartment_12045", "id": "reaction_10438409", "reactome": "R-DME-174368", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_162756" ], "products": [ "species_3499326", "species_174384" ], "modifiers": [ [ "species_10438406", "catalyst" ] ], "additional_components": [ "Q95YI5", "FBgn0042641" ] }, "reaction_10427874": { "compartment": "compartment_70101", "id": "reaction_10427874", "reactome": "R-DME-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548", "species_29494" ], "products": [ "species_111294", "species_29410" ], "modifiers": [ [ "species_10427871", "catalyst" ] ], "additional_components": [ "Q9VSW1", "FBgn0035978" ] }, "reaction_10437986": { "compartment": "compartment_70101", "id": "reaction_10437986", "reactome": "R-DME-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410", "species_29360" ], "products": [ "species_70106", "species_158601", "species_73473" ], "modifiers": [ [ "species_10437983", "catalyst" ] ], "additional_components": [ "O02373", "FBgn0261445" ] }, "reaction_10430076": { "compartment": "compartment_7660", "id": "reaction_10430076", "reactome": "R-DME-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430069" ], "products": [ "species_10430073", "species_10430063" ], "modifiers": [ [ "species_10430069", "catalyst" ] ], "additional_components": [ "Q24562", "FBgn0005411", "Q9VQF5", "FBgn0031452", "Q94535", "FBgn0017457", "Q9VTN7", "FBgn0036207", "P26686", "FBgn0004587", "Q9VHC7", "FBgn0267790", "Q08473", "FBgn0263396", "A1ZBW0", "FBgn0267791", "Q7KU81", "FBgn0259935", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "P19018", "FBgn0003742", "Q8MZI3", "FBgn0035720", "M9NEH9", "FBgn0262737", "E1JGL8", "FBgn0050122", "Q9W0Q2", "FBgn0035141", "Q9V3T8", "FBgn0265298", "Q02427", "FBgn0260944", "Q9VHC0", "FBgn0037707", "Q95RI7", "FBgn0039977", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VEP9", "FBgn0266917", "O46106", "FBgn0014366", "Q9VU15", "FBgn0036314", "Q7PL83", "FBgn0086683", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8T6B9", "FBgn0028577", "Q7K3M5", "FBgn0033160", "Q9VXW2", "FBgn0030631", "P43332", "FBgn0003449", "Q9V4Q8", "FBgn0033210", "Q59E33", "FBgn0261872", "Q9W2N6", "FBgn0034572", "Q9VMC8", "FBgn0031822", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9V9K7", "FBgn0033062", "Q9VL71", "FBgn0024285", "Q9W0B6", "FBgn0035249", "Q9VY54", "FBgn0026713", "Q9VU43", "FBgn0036340", "Q95RB1", "FBgn0037220", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7KNF2", "FBgn0005648", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q9VD52", "FBgn0038927", "P39736", "FBgn0004856", "Q9VHS8", "FBgn0037573", "Q9VCH9", "FBgn0039116", "A1Z9G2", "FBgn0033859", "Q9VJ87", "FBgn0086707", "Q95RE4", "FBgn0022959", "Q7KSN8", "FBgn0051368", "Q9VPY4", "FBgn0031318", "A0A023GRW3", "FBgn0031319", "O97454", "FBgn0001491", "Q9VKV5", "FBgn0032250", "P17886", "FBgn0000377", "Q9V3E7", "FBgn0010774", "Q9VHV6", "FBgn0037550", "Q7KLW9", "FBgn0261119", "Q9VHJ7", "FBgn0037644", "Q9VYQ9", "FBgn0030365", "Q9W0R0", "FBgn0265574", "O76861", "FBgn0024998", "P11147", "FBgn0266599", "Q9VAY6", "FBgn0039558", "Q9V3B6", "FBgn0040235", "Q9VF55", "FBgn0038345", "Q9V3W7", "FBgn0283477", "Q9V3V0", "FBgn0028554", "P24785", "FBgn0002774", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q27294", "FBgn0285954", "Q9VES0", "FBgn0038454", "Q9VIZ3", "FBgn0086444", "Q9VES0", "FBgn0038454", "Q24562", "FBgn0005411", "Q9VQF5", "FBgn0031452", "Q94535", "FBgn0017457", "P26686", "FBgn0004587", "Q9VHC7", "FBgn0267790", "Q08473", "FBgn0263396", "A1ZBW0", "FBgn0267791", "Q7KU81", "FBgn0259935", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "P19018", "FBgn0003742", "Q8MZI3", "FBgn0035720", "M9NEH9", "FBgn0262737", "E1JGL8", "FBgn0050122", "Q9W0Q2", "FBgn0035141", "Q9V3T8", "FBgn0265298", "Q02427", "FBgn0260944", "Q9VHC0", "FBgn0037707", "Q95RI7", "FBgn0039977", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", 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demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429728", "species_10429536", "species_10429650", "species_10429733", "species_10429638", "species_10429655", "species_10429704", "species_10429640", "species_10429721", "species_10429723", "species_10429660", "species_10429645" ], "products": [ "species_10429735", "species_10429529" ], "modifiers": [], "additional_components": [ "FBgn0086707", "Q9VQK5", "FBgn0031492", "Q9VHC7", "FBgn0267790", "Q27294", "FBgn0285954", "Q9VEJ1", "FBgn0025571", "P24785", "FBgn0002774", "A1ZBW0", "FBgn0267791", "Q9VU43", "FBgn0036340", "Q9V3V0", "FBgn0028554", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "Q9V3W7", "FBgn0283477", "Q9V9K7", "FBgn0033062", "P19018", "FBgn0003742", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429924", "species_10429735", "species_10429899", "species_10429867", "species_10429904", "species_10429872", "species_10429941", "species_10429909", "species_10429877", "species_10429914", "species_10429882", "species_10429919", "species_10429887" ], "products": [ "species_10429943", "species_10429534" ], "modifiers": [], "additional_components": [ "FBgn0050342", "Q24562", "FBgn0005411", "Q94535", "FBgn0017457", "P26686", "FBgn0004587", "Q7KU81", "FBgn0259935", "Q9V3T8", "FBgn0265298", "Q08473", "FBgn0263396", "Q02427", "FBgn0260944", "Q9VHC0", "FBgn0037707", "Q8MZI3", "FBgn0035720", "Q95RI7", "FBgn0039977", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VEP9", "FBgn0266917", "O46106", "FBgn0014366", "Q9VU15", "FBgn0036314", "Q7PL83", "FBgn0086683", "Q9VLV5", "FBgn0261790", "Q9VU02", 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computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment": "compartment_7660", "id": "reaction_10435479", "reactome": "R-DME-156661", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430113", "species_10430097" ], "products": [ "species_10430117" ], "modifiers": [], "additional_components": [ "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "P26686", "FBgn0004587", "Q9VHC7", "FBgn0267790", "Q08473", "FBgn0263396", "A1ZBW0", "FBgn0267791", "Q7KU81", "FBgn0259935", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "P19018", "FBgn0003742", "Q8MZI3", "FBgn0035720", "M9NEH9", "FBgn0262737", "E1JGL8", "FBgn0050122", "Q9W0Q2", "FBgn0035141", "Q9V3T8", "FBgn0265298", "Q02427", "FBgn0260944", "Q9VHC0", "FBgn0037707", "Q95RI7", "FBgn0039977", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VEP9", "FBgn0266917", "O46106", "FBgn0014366", "Q9VU15", "FBgn0036314", "Q7PL83", "FBgn0086683", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", 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event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430081", "species_10430083", "species_10430088", "species_10430073", "species_10430093" ], "products": [ "species_10430097" ], "modifiers": [], "additional_components": [ "FBgn0034923", "FBgn0003742", "FBgn0033556", "Q9VES0", "FBgn0038454", "Q24562", "FBgn0005411", "Q9VQF5", "FBgn0031452", "Q94535", "FBgn0017457", "P26686", "FBgn0004587", "Q9VHC7", "FBgn0267790", "Q08473", "FBgn0263396", "A1ZBW0", "FBgn0267791", "Q7KU81", "FBgn0259935", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "P19018", "FBgn0003742", "Q8MZI3", "FBgn0035720", "M9NEH9", "FBgn0262737", "E1JGL8", "FBgn0050122", "Q9W0Q2", "FBgn0035141", "Q9V3T8", "FBgn0265298", "Q02427", "FBgn0260944", "Q9VHC0", "FBgn0037707", "Q95RI7", "FBgn0039977", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VEP9", "FBgn0266917", "O46106", 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homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694509" ], "products": [ "species_422506", "species_70106", "species_76116" ], "modifiers": [ [ "species_10479001", "catalyst" ] ], "additional_components": [ "FBgn0034419" ] }, "reaction_10448215": { "compartment": "compartment_876", "id": "reaction_10448215", "reactome": "R-DME-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10448212", "catalyst" ] ], "additional_components": [ "FBgn0261244" ] }, "reaction_10478699": { "compartment": "compartment_20699", "id": "reaction_10478699", "reactome": "R-DME-5694418", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478691", "species_10478647", "species_10478684" ], "products": [ "species_10478697" ], "modifiers": [], "additional_components": [ "Q9W3N6", "FBgn0040087", "O18332", "FBgn0285937", "species_29438", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "Q9W3N6", "FBgn0040087", "O18332", "FBgn0285937", "species_29438", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855" ] }, "reaction_10478650": { "compartment": "compartment_13959", "id": "reaction_10478650", "reactome": "R-DME-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10478643" ], "products": [ "species_29420", "species_10478647" ], "modifiers": [ [ "species_10478643", "catalyst" ] ], "additional_components": [ "species_29420", "O18332", "FBgn0285937", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855", "O18332", "FBgn0285937", "species_29438", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855", "species_29420", "O18332", "FBgn0285937", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855" ] }, "reaction_10487625": { "compartment": "compartment_6791047", "id": "reaction_10487625", "reactome": "R-DME-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487621", "species_10486338" ], "products": [ "species_10487623" ], "modifiers": [], "additional_components": [ "FBgn0040005", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W5H8", "FBgn0040005" ] }, "reaction_10478773": { "compartment": "compartment_6791047", "id": "reaction_10478773", "reactome": "R-DME-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478768", "species_113592" ], "products": [ "species_10478736", "species_29372", "species_10478756", "species_10478741", "species_10478727", "species_10478746", "species_10478764", "species_10478751" ], "modifiers": [ [ "species_10478768", "catalyst" ] ], "additional_components": [ "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791", "Q23983", "FBgn0250791", "FBgn0011708", "FBgn0260857", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "FBgn0260856", "M9PGI6", "FBgn0260855", "FBgn0264978", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10478996": { "compartment": "compartment_6791047", "id": "reaction_10478996", "reactome": "R-DME-5694446", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478758", "species_10478892" ], "products": [ "species_10478994", "species_10478691", "species_10478684", "species_10478766" ], "modifiers": [], "additional_components": [ "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "Q9W3N6", "FBgn0040087", "M9PGI6", "FBgn0260855", "Q7JYA0", "FBgn0033873", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9V3A8", "FBgn0035909", "P49858", "FBgn0000339", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9W3N6", "FBgn0040087", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708" ] }, "reaction_10487628": { "compartment": "compartment_6791047", "id": "reaction_10487628", "reactome": "R-DME-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487623" ], "products": [ "species_10478404", "species_10487621" ], "modifiers": [ [ "species_10487623", "catalyst" ] ], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W5H8", "FBgn0040005", "species_29420", "O18332", "FBgn0285937", "FBgn0040005", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W5H8", "FBgn0040005" ] }, "reaction_10478770": { "compartment": "compartment_6791047", "id": "reaction_10478770", "reactome": "R-DME-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10478727", "species_10478766" ], "products": [ "species_10478768" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10442369": { "compartment": "compartment_70101", "id": "reaction_10442369", "reactome": "R-DME-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10442357" ], "products": [ "species_29420", "species_10442361" ], "modifiers": [ [ "species_10442366", "catalyst" ] ], "additional_components": [ "Q9VD29", "FBgn0038947", "species_29420", "Q9VD29", "FBgn0038947", "species_29438", "FBgn0031779" ] }, "reaction_10447503": { "compartment": "compartment_876", "id": "reaction_10447503", "reactome": "R-DME-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10447494", "catalyst" ] ], "additional_components": [ "FBgn0259214" ] }, "reaction_10455452": { "compartment": "compartment_70101", "id": "reaction_10455452", "reactome": "R-DME-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_947588", "species_113592" ], "products": [ "species_29372", "species_29370", "species_947594" ], "modifiers": [ [ "species_10455391", "catalyst" ] ], "additional_components": [ "species_33625", "species_1602375", "species_1602375", "species_33625", "B7YZF8", "FBgn0259221", "Q7KTG6", "FBgn0032120", "Q9VGD4", "FBgn0037989", "Q9VXG6", "FBgn0030747", "Q9VXG7", "FBgn0030746" ] }, "reaction_10447514": { "compartment": "compartment_114521", "id": "reaction_10447514", "reactome": "R-DME-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427899", "species_74016" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10447507", "catalyst" ] ], "additional_components": [] }, "reaction_10477993": { "compartment": "compartment_70101", "id": "reaction_10477993", "reactome": "R-DME-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29418", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1981162" ], "modifiers": [ [ "species_10477990", "catalyst" ] ], "additional_components": [ "FBgn0027582" ] }, "reaction_10455270": { "compartment": "compartment_20699", "id": "reaction_10455270", "reactome": "R-DME-936883", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_74016" ], "products": [ "species_29372", "species_29370", "species_167012" ], "modifiers": [ [ "species_10455267", "catalyst" ] ], "additional_components": [ "M9PG15", "FBgn0052451", "species_29926" ] }, "reaction_10455334": { "compartment": "compartment_876", "id": "reaction_10455334", "reactome": "R-DME-937311", "name": "ATP4A/12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_29356", "species_70106", "species_113592" ], "products": [ "species_351626", "species_29804", "species_29372", "species_29370" ], "modifiers": [ [ "species_10455331", "catalyst" ] ], "additional_components": [ "P13607", "FBgn0002921", "A8QI34", "FBgn0267363", "Q9VDY7", "FBgn0038691", "Q24046", "FBgn0015776", "Q9V3Q7", "FBgn0038690", "M9PDX8", "FBgn0032946", "Q7KT77", "FBgn0053310", "Q24048", "FBgn0015777" ] }, "reaction_10448436": { "compartment": "compartment_12045", "id": "reaction_10448436", "reactome": "R-DME-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_74016" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10448412", "catalyst" ], [ "species_10448434", "catalyst" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607" ] }, "reaction_10478001": { "compartment": "compartment_70101", "id": "reaction_10478001", "reactome": "R-DME-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5692450" ], "products": [ "species_29372", "species_29370", "species_5692484" ], "modifiers": [ [ "species_10477998", "catalyst" ] ], "additional_components": [ "FBgn0052000" ] }, "reaction_10448234": { "compartment": "compartment_876", "id": "reaction_10448234", "reactome": "R-DME-426086", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_188972", "species_74113" ], "products": [ "species_29804", "species_83910", "species_352022" ], "modifiers": [ [ "species_10448231", "catalyst" ] ], "additional_components": [ "M9PI37", "FBgn0036279", "Q9VNC7", "FBgn0051547" ] }, "reaction_10448243": { "compartment": "compartment_876", "id": "reaction_10448243", "reactome": "R-DME-426130", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_74113" ], "products": [ "species_83910", "species_352022" ], "modifiers": [ [ "species_10448240", "catalyst" ] ], "additional_components": [ "Q9VNC7", "FBgn0051547", "M9PI37", "FBgn0036279" ] }, "reaction_10464875": { "compartment": "compartment_70101", "id": "reaction_10464875", "reactome": "R-DME-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464873" ], "products": [ "species_10443056" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016" ] }, "reaction_10443076": { "compartment": "compartment_70101", "id": "reaction_10443076", "reactome": "R-DME-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443056" ], "products": [ "species_10443074" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VLW8", "FBgn0031951" ] }, "reaction_10431293": { "compartment": "compartment_5460", "id": "reaction_10431293", "reactome": "R-DME-73916", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559" ], "products": [ "species_29374", "species_73871" ], "modifiers": [ [ "species_10428434", "catalyst" ] ], "additional_components": [ "Q9W3N9", "FBgn0029969" ] }, "reaction_10431485": { "compartment": "compartment_5460", "id": "reaction_10431485", "reactome": "R-DME-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_113559", "species_73909" ], "modifiers": [ [ "species_10431482", "catalyst" ] ], "additional_components": [ "Q9VM58", "FBgn0031877" ] }, "reaction_10431291": { "compartment": "compartment_5460", "id": "reaction_10431291", "reactome": "R-DME-73912", "name": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_73909", "species_29362" ], "products": [ "species_113526", "species_73911" ], "modifiers": [ [ "species_10431288", "catalyst" ] ], "additional_components": [ "Q7K3N4", "FBgn0033679" ] }, "reaction_10491097": { "compartment": "compartment_5460", "id": "reaction_10491097", "reactome": "R-DME-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10491094", "catalyst" ] ], "additional_components": [ "FBgn0039184" ] }, "reaction_10479990": { "compartment": "compartment_70101", "id": "reaction_10479990", "reactome": "R-DME-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10479987", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VM58", "FBgn0031877" ] }, "reaction_10431301": { "compartment": "compartment_5460", "id": "reaction_10431301", "reactome": "R-DME-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10431298", "catalyst" ] ], "additional_components": [ "FBgn0010611" ] }, "reaction_10479039": { "compartment": "compartment_20699", "id": "reaction_10479039", "reactome": "R-DME-5694487", "name": "A4GNT transfers GlcNAc to core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454881" ], "products": [ "species_10479031", "species_205687" ], "modifiers": [ [ "species_10479036", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "FBgn0031491" ] }, "reaction_10454637": { "compartment": "compartment_20699", "id": "reaction_10454637", "reactome": "R-DME-913675", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10454542" ], "products": [ "species_10454561", "species_205687" ], "modifiers": [ [ "species_10454634", "catalyst" ] ], "additional_components": [ "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9Y117", "FBgn0027558", "Q6WV17", "FBgn0031681", "Q8MV48", "FBgn0030930", "Q6WV19", "FBgn0031530", "Q6WV20", "FBgn0034025", "Q8MYY6", "FBgn0039596", "Q8MRC9", "FBgn0050463", "Q8MVS5", "FBgn0001970" ] }, "reaction_10462333": { "compartment": "compartment_20699", "id": "reaction_10462333", "reactome": "R-DME-1964505", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454561", "species_735682" ], "products": [ "species_205687", "species_10454862" ], "modifiers": [ [ "species_10462330", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VQH4", "FBgn0031466", "A8JNT3", "FBgn0085480", "Q9VQI0", "FBgn0031472", "Q7K237", "FBgn0032078", "A8JNT2", "FBgn0085481", "Q9VQH7", "FBgn0031469", "Q7JRF9", "FBgn0033271", "Q9W0L4", "FBgn0054056", "Q9VQH6", "FBgn0031468", "Q2PE08", "FBgn0054057", "Q9VWM1", "FBgn0030984" ] }, "reaction_10479773": { "compartment": "compartment_20699", "id": "reaction_10479773", "reactome": "R-DME-6786012", "name": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454881", "species_741440" ], "products": [ "species_742343", "species_10479764" ], "modifiers": [ [ "species_10479770", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VMC4", "FBgn0031826", "Q9VMC3", "FBgn0051637" ] }, "reaction_10462269": { "compartment": "compartment_17963", "id": "reaction_10462269", "reactome": "R-DME-1964501", "name": "Addition of galactose to Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10454714" ], "products": [ "species_10462264", "species_205687" ], "modifiers": [ [ "species_10462266", "catalyst" ] ], "additional_components": [ "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10454716": { "compartment": "compartment_17963", "id": "reaction_10454716", "reactome": "R-DME-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454561" ], "products": [ "species_10454714", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004" ] }, "reaction_10454843": { "compartment": "compartment_20699", "id": "reaction_10454843", "reactome": "R-DME-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454561" ], "products": [ "species_205687", "species_10454735" ], "modifiers": [ [ "species_10454840", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VZA6", "FBgn0035558", "Q95RP8", "FBgn0040373", "A1Z8R6", "FBgn0053145", "A1Z8R5", "FBgn0050037", "A1Z8R4", "FBgn0050036", "Q9VLT0", "FBgn0031986", "Q9VLS8", "FBgn0031988" ] }, "reaction_10454695": { "compartment": "compartment_17963", "id": "reaction_10454695", "reactome": "R-DME-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454561", "species_735682" ], "products": [ "species_10454693", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167" ] }, "reaction_10454902": { "compartment": "compartment_17963", "id": "reaction_10454902", "reactome": "R-DME-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10454561" ], "products": [ "species_10454900", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167" ] }, "reaction_10454674": { "compartment": "compartment_17963", "id": "reaction_10454674", "reactome": "R-DME-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454561" ], "products": [ "species_10454672", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167" ] }, "reaction_10470740": { "compartment": "compartment_12045", "id": "reaction_10470740", "reactome": "R-DME-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470732" ], "products": [ "species_10470564" ], "modifiers": [ [ "species_10470737", "catalyst" ] ], "additional_components": [ "Q9VM97", "FBgn0031850", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9W493", "FBgn0029791", "Q9W493", "FBgn0029791", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9VM97", "FBgn0031850", "FBgn0027791" ] }, "reaction_10470658": { "compartment": "compartment_12045", "id": "reaction_10470658", "reactome": "R-DME-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470564", "species_173594" ], "products": [ "species_158602", "species_10470650" ], "modifiers": [ [ "species_10470655", "catalyst" ] ], "additional_components": [ "Q9W493", "FBgn0029791", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9VM97", "FBgn0031850", "Q9W493", "FBgn0029791", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9VM97", "FBgn0031850", "FBgn0031765" ] }, "reaction_10449358": { "compartment": "compartment_984", "id": "reaction_10449358", "reactome": "R-DME-432164", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10449355", "catalyst" ], [ "species_9635195", "inhibitor" ] ], "additional_components": [ "Q7KRY7", "FBgn0263289", "P18091", "FBgn0000667", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "Q00168", "FBgn0264607", "CHEBI:16523", "species_29424", "species_210382" ] }, "reaction_10449740": { "compartment": "compartment_876", "id": "reaction_10449740", "reactome": "R-DME-438037", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10446948", "catalyst" ], [ "species_10449738", "catalyst" ] ], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q7KRY7", "FBgn0263289", "P18091", "FBgn0000667", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "CHEBI:16523", "species_29424", "species_210382" ] }, "reaction_10497396": { "compartment": "compartment_12045", "id": "reaction_10497396", "reactome": "R-DME-9609742", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497390", "species_10497392" ], "products": [ "species_10497394" ], "modifiers": [], "additional_components": [ "FBgn0010399", "FBgn0053513", "Q9W581", "FBgn0053513", "Q24418", "FBgn0010399" ] }, "reaction_10497508": { "compartment": "compartment_12045", "id": "reaction_10497508", "reactome": "R-DME-9610750", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497506" ], "products": [ "species_10449322" ], "modifiers": [], "additional_components": [ "Q9W581", "FBgn0053513", "Q24418", "FBgn0010399", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513" ] }, "reaction_10493706": { "compartment": "compartment_70101", "id": "reaction_10493706", "reactome": "R-DME-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434305", "species_30389" ], "products": [ "species_10434307" ], "modifiers": [], "additional_components": [ "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "species_30389", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243" ] }, "reaction_10434269": { "compartment": "compartment_7660", "id": "reaction_10434269", "reactome": "R-DME-111915", "name": "CAMK4 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10434260" ], "products": [ "species_113582", "species_10434266" ], "modifiers": [ [ "species_10434260", "catalyst" ] ], "additional_components": [ "Q7PLI7", "FBgn0261387", "species_74016", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q7PLI7", "FBgn0261387", "species_74016", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q7PLI7", "FBgn0261387", "species_74016", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273" ] }, "reaction_10435620": { "compartment": "compartment_70101", "id": "reaction_10435620", "reactome": "R-DME-157849", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435618", "species_10430440", "species_10430463" ], "products": [ "species_10430440", "species_10430508" ], "modifiers": [], "additional_components": [ "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10435555": { "compartment": "compartment_70101", "id": "reaction_10435555", "reactome": "R-DME-156808", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430440", "species_10435546", "species_10435551", "species_10430463" ], "products": [ "species_10435553", "species_10430440" ], "modifiers": [], "additional_components": [ "FBgn0026250", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0265297", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P21187", "FBgn0265297", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0026250" ] }, "reaction_10497375": { "compartment": "compartment_13231", "id": "reaction_10497375", "reactome": "R-DME-9604308", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497365" ], "products": [ "species_10443303" ], "modifiers": [ [ "species_10497373", "inhibitor" ] ], "additional_components": [ "FBgn0051665", "FBgn0051665", "P29310", "14-3-3zeta", "Q7KU08", "FBgn0051665" ] }, "reaction_10446682": { "compartment": "compartment_984", "id": "reaction_10446682", "reactome": "R-DME-390886", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445670", "species_390899" ], "products": [ "species_10445672" ], "modifiers": [], "additional_components": [ "FBgn0000037", "species_390899", "P16395", "FBgn0000037" ] }, "reaction_10498568": { "compartment": "compartment_984", "id": "reaction_10498568", "reactome": "R-DME-9692880", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10498564" ], "products": [ "species_10498566" ], "modifiers": [], "additional_components": [ "FBgn0000037", "P16395", "FBgn0000037", "species_390899" ] }, "reaction_10496054": { "compartment": "compartment_70101", "id": "reaction_10496054", "reactome": "R-DME-9009308", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496029", "species_10426987" ], "products": [ "species_10456460", "species_10496051" ], "modifiers": [ [ "species_10496029", "catalyst" ] ], "additional_components": [ "Q9XYW6", "FBgn0027052", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0027052", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "Q9XYW6", "FBgn0027052", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10492551": { "compartment": "compartment_7660", "id": "reaction_10492551", "reactome": "R-DME-8939706", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10492520" ], "products": [ "species_10427449", "species_10492548" ], "modifiers": [ [ "species_10492520", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10496056": { "compartment": "compartment_70101", "id": "reaction_10496056", "reactome": "R-DME-9009309", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496027", "species_10456460" ], "products": [ "species_10496029" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "FBgn0027052", "Q9XYW6", "FBgn0027052", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10492553": { "compartment": "compartment_7660", "id": "reaction_10492553", "reactome": "R-DME-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492548" ], "products": [ "species_10427430" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10492522": { "compartment": "compartment_7660", "id": "reaction_10492522", "reactome": "R-DME-8939688", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491656", "species_10427449" ], "products": [ "species_10492520" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_538904": { "compartment": "compartment_7660", "id": "reaction_538904", "reactome": "R-DME-538904", "name": "Phosphorylated PER binds to CLK", "reversible": "false", "notes": "After Timeless (TIM) and Period (PER) reform their heterodimer, PER binds to the E-box bound Clock (CLK) protein. Transcription of the per, tim, vri, and Pdp1 target genes is now deactivated. It appears that PER directly binds to CLK, whereas itself and TIM do not bind to Cycle (CYC). PER binding to CLK is in itself not sufficient for inhibition.", "reactants": [ "species_881986", "species_881995" ], "products": [ "species_882012" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_538891": { "compartment": "compartment_7660", "id": "reaction_538891", "reactome": "R-DME-538891", "name": "CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes", "reversible": "false", "notes": "The deactivation of the Clock (CLK):Cycle (CYC) heterodimer and subsequent deactivation of the per, tim, vri, and Pdp1 target genes causes the CLK:CYC heterodimer to be released from its binding to its target genes, sequestered in a stable complex with PER and TIM to reinforce the transcription inhibition. Towards the end of the night Period (PER) and Timeless (TIM) proteins are at their peak level.", "reactants": [ "species_881925" ], "products": [ "species_881962", "species_29428" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC" ] }, "reaction_432513": { "compartment": "compartment_7660", "id": "reaction_432513", "reactome": "R-DME-432513", "name": "CLK is phosphorylated by DCO", "reversible": "false", "notes": "Clock (CLK) protein is now phosphorylated on unknown serine/threonine residues by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO). It is not yet known whether other kinases are involved in phosphorylating CLK, potentially brought to there via interactions with DCO and Period (PER) acting as scaffolding proteins. There is also evidence from mammalian systems that chromatin remodelling factors are brought in by the PER scaffold and are responsible for a sustained state of transcription inhibition in these genes.", "reactants": [ "species_29358", "species_882012" ], "products": [ "species_113582", "species_881925" ], "modifiers": [ [ "species_882012", "catalyst" ] ], "additional_components": [ "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432381": { "compartment": "compartment_7660", "id": "reaction_432381", "reactome": "R-DME-432381", "name": "PDP1 replaces VRI as binder to Clk and cry genes", "reversible": "false", "notes": "PAR domain protein-1 (PDP1) levels reach their peak between mid to late night. Vrille (VRI) levels decline during this time due to TIM:PER:DCO mediated repression of Clock (CLK) driven vri transcription. The decreasing ratio of VRI/PDP1 levels favours binding of PDP1 over VRI to the V/P boxes resulting in activation of Clk and cry transcription.", "reactants": [ "species_881990", "species_432423" ], "products": [ "species_432467", "species_881966" ], "modifiers": [], "additional_components": [ "Q9VMS4", "VRI", "Q24217", "PDP1" ] }, "reaction_538900": { "compartment": "compartment_7660", "id": "reaction_538900", "reactome": "R-DME-538900", "name": "Phosphorylated PER rebinds to phosphorylated TIM", "reversible": "false", "notes": "Once in the nucleus, phosphorylated Timeless (TIM) and Period (PER) reform their heterodimer.", "reactants": [ "species_881991", "species_432657" ], "products": [ "species_881995" ], "modifiers": [], "additional_components": [ "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO" ] }, "reaction_432516": { "compartment": "compartment_7660", "id": "reaction_432516", "reactome": "R-DME-432516", "name": "CLK and CYC bind to form a heterodimer", "reversible": "false", "notes": "The basic-helix-loop-helix PAS (PER-ARNT-SIM) domain transcription factors, Clock (CLK) and Cycle (CYC) bind and form a heterodimer.", "reactants": [ "species_432489", "species_432557" ], "products": [ "species_432591" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432436": { "compartment": "compartment_7660", "id": "reaction_432436", "reactome": "R-DME-432436", "name": "CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes", "reversible": "false", "notes": "At midday, the Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target genes, per, tim, vri, and Pdp1. Transcription of these genes is now activated.", "reactants": [ "species_432591", "species_29428" ], "products": [ "species_881986" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432593": { "compartment": "compartment_70101", "id": "reaction_432593", "reactome": "R-DME-432593", "name": "Cytosolic JET binds to CRY, facilitating its ubiquitination", "reversible": "false", "notes": "After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY), facilitating its ubiquitination, marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.", "reactants": [ "species_206204", "species_432571", "species_432574" ], "products": [ "species_432576" ], "modifiers": [ [ "species_432571", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "O77059", "CRY", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_432428": { "compartment": "compartment_70101", "id": "reaction_432428", "reactome": "R-DME-432428", "name": "Cytosolic CRY is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated cryptochrome (CRY) is degraded by the 26S proteasome.", "reactants": [ "species_432576" ], "products": [ "species_206204", "species_432571" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "O77059", "CRY", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_432652": { "compartment": "compartment_7660", "id": "reaction_432652", "reactome": "R-DME-432652", "name": "Nuclear CRY is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated cryptochrome (CRY) is degraded by the 26S proteasome.", "reactants": [ "species_432418" ], "products": [ "species_432393", "species_216110" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "O77059", "CRY", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432378": { "compartment": "compartment_7660", "id": "reaction_432378", "reactome": "R-DME-432378", "name": "Nuclear JET binds CRY, facilitating its ubiquitination", "reversible": "false", "notes": "After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY), facilitating its ubiquitination and marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.", "reactants": [ "species_432393", "species_216110", "species_432582" ], "products": [ "species_432418" ], "modifiers": [ [ "species_432393", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O77059", "CRY", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET" ] }, "reaction_432510": { "compartment": "compartment_7660", "id": "reaction_432510", "reactome": "R-DME-432510", "name": "CLK is degraded by the 26S proteasome", "reversible": "false", "notes": "Hyperphosphorylated Clock (CLK) is degraded by the 26S proteasome via an unknown intermediate mechanism.", "reactants": [ "species_432621" ], "products": [ "species_432489" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432455": { "compartment": "compartment_7660", "id": "reaction_432455", "reactome": "R-DME-432455", "name": "Nuclear PER is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Period (PER) is degraded by the 26S proteasome.", "reactants": [ "species_882001" ], "products": [ "species_216110", "species_432621", "species_432399", "species_432469" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "O44382", "SLMB", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61734", "CYC", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61735", "Phospho CLK", "O61734", "CYC", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432483": { "compartment": "compartment_7660", "id": "reaction_432483", "reactome": "R-DME-432483", "name": "SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination", "reversible": "false", "notes": "During the day, with levels of its stabilising partner Timeless (TIM) drastically reduced by light, hyperphosphorylated Period (PER) becomes a target for the F-box containing protein, supernumerary limbs (SLMB). Ser47 phosphorylation of Period (PER) appears to be the trigger for SLMB to bind phosphorylated PER, facilitating its ubiquitination and marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for PER degradation are the same.", "reactants": [ "species_216110", "species_881927", "species_432469" ], "products": [ "species_882001" ], "modifiers": [ [ "species_432469", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "O61734", "CYC", "O44382", "SLMB", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61734", "CYC" ] }, "reaction_432411": { "compartment": "compartment_70101", "id": "reaction_432411", "reactome": "R-DME-432411", "name": "SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination", "reversible": "false", "notes": "During the day, with levels of its stabilising partner Timeless (TIM) drastically reduced by light, hyperphosphorylated Period (PER) becomes a target for the F-box containing protein, supernumerary limbs (SLMB). Ser47 phosphorylation of Period (PER) appears to be the trigger for SLMB to bind and facilitate ubiquitination of phosphorylated PER, marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for PER degradation are the same.", "reactants": [ "species_206204", "species_881987", "species_206299" ], "products": [ "species_881958" ], "modifiers": [ [ "species_206299", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O44382", "SLMB", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_432361": { "compartment": "compartment_70101", "id": "reaction_432361", "reactome": "R-DME-432361", "name": "Cytosolic PER is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Period (PER) is degraded by the 26S proteasome.", "reactants": [ "species_881958" ], "products": [ "species_206204", "species_206299", "species_205729" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O44382", "SLMB", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_432527": { "compartment": "compartment_7660", "id": "reaction_432527", "reactome": "R-DME-432527", "name": "Nuclear PP2A dephosphorylates phosphorylated PER", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Widerborst (WDB), helps stabilise hyperphosphorylated Period (PER) by dephosphorylating it and so prevent it from degradation. PP2A also seems to speed up nuclear import of PER. This is probably a secondary effect of stabilising PER.", "reactants": [ "species_881962" ], "products": [ "species_113550", "species_881965" ], "modifiers": [ [ "species_432603", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "P23696", "mts", "Q9VB23", "WDB", "P36179", "Pp2A-29B" ] }, "reaction_432556": { "compartment": "compartment_70101", "id": "reaction_432556", "reactome": "R-DME-432556", "name": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Twins (TWS), helps stabilise hyperphosphorylated Period (PER), within the PER:DCO complex, by dephosphorylating it and so prevent it from degradation. PP2A likely dephosphorylates the site phosphorylated by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) as it stabilises PER.", "reactants": [ "species_881987" ], "products": [ "species_432347", "species_29372" ], "modifiers": [ [ "species_206938", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_538822": { "compartment": "compartment_70101", "id": "reaction_538822", "reactome": "R-DME-538822", "name": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Twins (TWS), helps stabilise hyperphosphorylated Period (PER), within the PER:DCO complex, by dephosphorylating it and so prevent it from degradation. PP2A likely dephosphorylates the site phosphorylated by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) as it stabilises PER.", "reactants": [ "species_881967" ], "products": [ "species_29372", "species_432413" ], "modifiers": [ [ "species_206938", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_538824": { "compartment": "compartment_70101", "id": "reaction_538824", "reactome": "R-DME-538824", "name": "PP1 binds to phosphorylated TIM in complex with PER", "reversible": "false", "notes": "The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).", "reactants": [ "species_881944", "species_432645" ], "products": [ "species_882002" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "O76324", "DCO", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM" ] }, "reaction_432533": { "compartment": "compartment_70101", "id": "reaction_432533", "reactome": "R-DME-432533", "name": "PP1 binds to phosphorylated TIM", "reversible": "false", "notes": "The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).", "reactants": [ "species_432363", "species_432645" ], "products": [ "species_432543" ], "modifiers": [], "additional_components": [ "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P49021", "TIM" ] }, "reaction_538832": { "compartment": "compartment_70101", "id": "reaction_538832", "reactome": "R-DME-538832", "name": "PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO", "reversible": "false", "notes": "The protein phosphatase, PP1, dephosphorylates and stabilises Timeless (TIM) which helps promote the accumulation of Period (PER).", "reactants": [ "species_882002" ], "products": [ "species_29372", "species_881912", "species_432645" ], "modifiers": [ [ "species_882002", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P49021", "TIM", "P07663", "Phospho (multi-site 2) PER", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "O76324", "DCO", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM" ] }, "reaction_432427": { "compartment": "compartment_70101", "id": "reaction_432427", "reactome": "R-DME-432427", "name": "PP1 dephosphorylates phosphorylated TIM", "reversible": "false", "notes": "The protein phosphatase, PP1, dephosphorylates and stabilises Timeless (TIM) which helps promote the accumulation of Period (PER).", "reactants": [ "species_432543" ], "products": [ "species_29372", "species_432355", "species_432645" ], "modifiers": [ [ "species_432543", "catalyst" ] ], "additional_components": [ "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P49021", "TIM", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P49021", "TIM" ] }, "reaction_432642": { "compartment": "compartment_13231", "id": "reaction_432642", "reactome": "R-DME-432642", "name": "Phosphorylated TIM transports from the cytosol to the nucleus", "reversible": "false", "notes": "After the phosphorylated Period (PER):Discs Overgrown (DCO) complex has entered the nucleus, phosphorylated Timeless (TIM) does the same. The time frame between the two events appears to be variable, depending on the type of neuronal clock cell, and can be up to a few hours later. It is currently not known whether casein kinase II (CK2) is bound to PER and/or TIM and whether it travels with either from the cytosol to the nucleus.", "reactants": [ "species_432363" ], "products": [ "species_432657" ], "modifiers": [], "additional_components": [] }, "reaction_432544": { "compartment": "compartment_13231", "id": "reaction_432544", "reactome": "R-DME-432544", "name": "Phosphorylated PER transports from the cytosol to the nucleus", "reversible": "false", "notes": "Phosphorylated Period (PER):Discs Overgrown (DCO) complex is imported into the nucleus from the cytosol.", "reactants": [ "species_882007" ], "products": [ "species_881991" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO" ] }, "reaction_432371": { "compartment": "compartment_7660", "id": "reaction_432371", "reactome": "R-DME-432371", "name": "CRY is activated by light and binds to phosphorylated nuclear TIM", "reversible": "false", "notes": "At dawn, a light-induced conformational change in the blue-light photoreceptor cryptochrome (CRY) promotes the formation of a complex with phosphorylated Timeless (TIM). In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for TIM degradation are the same. Also, in flies kept in constant darkness for many days, TIM levels still undergo daily oscillations, although not as robust as in light-dark cycles. The mechanism that drives daily cycles in TIM levels during extended periods in complete darkness is not clear.", "reactants": [ "species_881962", "species_432582" ], "products": [ "species_881922", "species_881927" ], "modifiers": [ [ "species_432508", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "O77059", "CRY", "P49021", "TIM", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "O61734", "CYC" ] }, "reaction_432401": { "compartment": "compartment_70101", "id": "reaction_432401", "reactome": "R-DME-432401", "name": "JET binds cytosolic TIM, facilitating its ubiquitination", "reversible": "false", "notes": "There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and TIM helps promote the interaction between the F-box domain containing protein JET with TIM. This interaction targets TIM for ubiquitination, marking it for processing by the 26S proteasome.", "reactants": [ "species_206204", "species_432571", "species_881918" ], "products": [ "species_881984", "species_432574" ], "modifiers": [ [ "species_432571", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P49021", "TIM", "O77059", "CRY", "P49021", "TIM", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_432426": { "compartment": "compartment_70101", "id": "reaction_432426", "reactome": "R-DME-432426", "name": "CRY is activated by light and binds to cytosolic TIM", "reversible": "false", "notes": "At dawn, a light-induced conformational change in the blue-light photoreceptor cryptochrome (CRY) promotes the formation of a complex with Timeless (TIM). In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for TIM degradation are the same. Also, in flies kept in constant darkness for many days, TIM levels still undergo daily oscillations, although not as robust as in light-dark cycles. The mechanism that drives daily cycles in TIM levels during extended periods in complete darkness is not clear.", "reactants": [ "species_432574", "species_432355" ], "products": [ "species_881918" ], "modifiers": [ [ "species_432604", "catalyst" ] ], "additional_components": [ "P49021", "TIM", "O77059", "CRY" ] }, "reaction_432507": { "compartment": "compartment_70101", "id": "reaction_432507", "reactome": "R-DME-432507", "name": "Cytosolic TIM is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.", "reactants": [ "species_881984" ], "products": [ "species_206204", "species_432571" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "P49021", "TIM", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_432424": { "compartment": "compartment_7660", "id": "reaction_432424", "reactome": "R-DME-432424", "name": "JET binds phosphorylated nuclear TIM, facilitating its ubiquitination", "reversible": "false", "notes": "There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and phosphorylated TIM helps promote the interaction between the F-box domain containing protein JET with phosphorylated TIM, facilitating ubiquitination of the latter protein, marking it for processing by the 26S proteasome.", "reactants": [ "species_432393", "species_881922", "species_216110" ], "products": [ "species_882000", "species_432582" ], "modifiers": [ [ "species_432393", "catalyst" ] ], "additional_components": [ "O77059", "CRY", "P49021", "TIM", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P49021", "TIM", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET" ] }, "reaction_432521": { "compartment": "compartment_7660", "id": "reaction_432521", "reactome": "R-DME-432521", "name": "Nuclear TIM is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.", "reactants": [ "species_882000" ], "products": [ "species_432393", "species_216110" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "P49021", "TIM", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432487": { "compartment": "compartment_7660", "id": "reaction_432487", "reactome": "R-DME-432487", "name": "CWO binds to cwo gene and represses transcription", "reversible": "false", "notes": "Clockwork Orange (CWO) binds to the E-box of its own gene, cwo, and represses it's own transcription in a negative feedback loop.", "reactants": [ "species_29428", "species_432566" ], "products": [ "species_881926" ], "modifiers": [], "additional_components": [ "Q9VGZ5", "CWO" ] }, "reaction_432520": { "compartment": "compartment_7660", "id": "reaction_432520", "reactome": "R-DME-432520", "name": "CLK:CYC heterodimer binds to cwo gene and activates transcription", "reversible": "false", "notes": "The Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target gene, cwo. Transcription of cwo is now activated.", "reactants": [ "species_432591", "species_29428" ], "products": [ "species_881986" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432647": { "compartment": "compartment_70101", "id": "reaction_432647", "reactome": "R-DME-432647", "name": "Phosphorylated PER binds to TIM", "reversible": "false", "notes": "After dusk, per and tim genes continue to be transcribed and their mRNAs reach peak levels between during the early part of the night. Timeless (TIM) protein is stable in the dark and so begins to accumulate and forms a complex with Period (PER) and Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). TIM stabilises PER despite the continuous attentions of casein kinase II (CK2) and DCO. As a result, PER and TIM accumulate to high levels during the middle of the night.", "reactants": [ "species_881987", "species_432355" ], "products": [ "species_881967" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM" ] }, "reaction_432535": { "compartment": "compartment_70101", "id": "reaction_432535", "reactome": "R-DME-432535", "name": "TIM is phosphorylated by CK2", "reversible": "false", "notes": "Timeless (TIM) is phosphorylated on unknown serine/threonine residues by casein kinase II (CK2). CK2 phosphorylation appears to be important for subsequent nuclear entry of TIM.", "reactants": [ "species_113592", "species_881912" ], "products": [ "species_29370", "species_881944" ], "modifiers": [ [ "species_206956", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P49021", "TIM", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "P11346", "Raf", "Q7KNQ9", "cnk", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P92177", "14-3-3epsilon", "Q9V9J3", "phospho-Src42A", "Q8ML92", "AVE", "P08646", "RAS85D", "species_29438", "Q24170", "Phospho KSR" ] }, "reaction_432464": { "compartment": "compartment_70101", "id": "reaction_432464", "reactome": "R-DME-432464", "name": "Phosphorylated TIM:PER heterodimer dissociate", "reversible": "false", "notes": "The phosphorylation of Timeless (TIM) and Period (PER) by casein kinase II (CK2) appears to be the trigger for their nuclear entry. However, before this occurs, phosphorylated TIM dissociates from the PER:Discs Overgrown (DCO) complex.", "reactants": [ "species_881944" ], "products": [ "species_432363", "species_882007" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER" ] }, "reaction_432590": { "compartment": "compartment_70101", "id": "reaction_432590", "reactome": "R-DME-432590", "name": "Phosphorylated PER is phosphorylated by CK2", "reversible": "false", "notes": "Phosphorylated Period (PER) is phosphorylated on serine residues 149, 151, 153, by casein kinase II (CK2). CK2 phosphorylation appears to be important for subsequent nuclear entry of PER.", "reactants": [ "species_113592", "species_881967" ], "products": [ "species_29370", "species_881912" ], "modifiers": [ [ "species_206956", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P49021", "TIM", "P07663", "Phospho (multi-site 2) PER", "P11346", "Raf", "Q7KNQ9", "cnk", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P92177", "14-3-3epsilon", "Q9V9J3", "phospho-Src42A", "Q8ML92", "AVE", "P08646", "RAS85D", "species_29438", "Q24170", "Phospho KSR" ] }, "reaction_432559": { "compartment": "compartment_70101", "id": "reaction_432559", "reactome": "R-DME-432559", "name": "PER is phosphorylated by DCO", "reversible": "false", "notes": "Period (PER) is phosphorylated on between 15-20 individual serine and threonine sites by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). During the day, when light activated regulation of Timeless (TIM) occurs and its levels are low, phosphorylated PER is susceptible to supernumerary limbs (SLMB) mediated ubiquitination and degradation. Ser47 and possibly other phosphorylated residues nearby are key phospho-signals on PER mediating the binding of SLMB to PER.", "reactants": [ "species_432347", "species_113592" ], "products": [ "species_881987", "species_29370" ], "modifiers": [ [ "species_206741", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_881988": { "compartment": "compartment_70101", "id": "reaction_881988", "reactome": "R-DME-881988", "name": "CRY is phosphorylated by SGG", "reversible": "false", "notes": "The blue-light photoreceptor cryptochrome (CRY) is phosphorylated on unknown serine/threonine residues by GSK3beta kinase orthologue, Shaggy (SGG). Phosphorylation appears to attenuate the function of CRY and it doesn't degrade Timeless (TIM). Earlier studies suggested that the effect of SGG on the light-mediated degradation of TIM was due to direct phosphorylation of TIM by SGG (Martinek et al., 2001), however, more recent experiments suggest the actual target of SGG in this pathway is CRY (Storelu et al., 2007).", "reactants": [ "species_113592", "species_432574" ], "products": [ "species_29370", "species_882013" ], "modifiers": [ [ "species_206898", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_538835": { "compartment": "compartment_70101", "id": "reaction_538835", "reactome": "R-DME-538835", "name": "PER binds to DCO", "reversible": "false", "notes": "The Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT) forms a complex with Period (PER).", "reactants": [ "species_432515", "species_205729" ], "products": [ "species_432347" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER" ] }, "reaction_432537": { "compartment": "compartment_7660", "id": "reaction_432537", "reactome": "R-DME-432537", "name": "PP2A dephosphorylates phosphorylated CLK", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Widerborst (WDB), helps stabilise hyperphosphorylated Clock (CLK) by dephosphorylating it and so prevent it from degradation. CLK levels remain relatively constant because hypophosphorylated CLK is generated by de novo synthesis or by dephosphorylation of existent hyperphosphorylated CLK.", "reactants": [ "species_432621" ], "products": [ "species_113550", "species_432591" ], "modifiers": [ [ "species_432603", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "O61734", "CYC", "P23696", "mts", "Q9VB23", "WDB", "P36179", "Pp2A-29B" ] }, "reaction_10456268": { "compartment": "compartment_876", "id": "reaction_10456268", "reactome": "R-DME-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437245", "species_983438" ], "products": [ "species_10456122" ], "modifiers": [], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10456252": { "compartment": "compartment_876", "id": "reaction_10456252", "reactome": "R-DME-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437285", "species_983438" ], "products": [ "species_10456083" ], "modifiers": [], "additional_components": [ "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10438059": { "compartment": "compartment_984", "id": "reaction_10438059", "reactome": "R-DME-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10437271" ], "products": [ "species_10438057" ], "modifiers": [], "additional_components": [ "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10431519": { "compartment": "compartment_70101", "id": "reaction_10431519", "reactome": "R-DME-74242", "name": "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500172" ], "products": [ "species_113599", "species_500244" ], "modifiers": [ [ "species_10431516", "catalyst" ] ], "additional_components": [ "CHEBI:28997", "species_83927", "CHEBI:28542", "species_112016", "Q9W1K6", "FBgn0034898", "M9PE19", "FBgn0035348" ] }, "reaction_10431551": { "compartment": "compartment_70101", "id": "reaction_10431551", "reactome": "R-DME-74255", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_83956" ], "products": [ "species_31633", "species_30064" ], "modifiers": [ [ "species_10431548", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VMY9", "FBgn0261436" ] }, "reaction_10431529": { "compartment": "compartment_70101", "id": "reaction_10431529", "reactome": "R-DME-74247", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29356", "species_29368" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10431526", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "P10351", "FBgn0003308" ] }, "reaction_10466119": { "compartment": "compartment_70101", "id": "reaction_10466119", "reactome": "R-DME-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10466110", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VMW7", "FBgn0031663" ] }, "reaction_10431541": { "compartment": "compartment_70101", "id": "reaction_10431541", "reactome": "R-DME-74249", "name": "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500245" ], "products": [ "species_83956", "species_500244" ], "modifiers": [ [ "species_10431516", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:16750", "CHEBI:28542", "species_112016", "Q9W1K6", "FBgn0034898", "M9PE19", "FBgn0035348" ] }, "reaction_10465661": { "compartment": "compartment_70101", "id": "reaction_10465661", "reactome": "R-DME-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10465656", "catalyst" ] ], "additional_components": [ "FBgn0037911" ] }, "reaction_10465659": { "compartment": "compartment_70101", "id": "reaction_10465659", "reactome": "R-DME-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395880" ], "products": [ "species_29372", "species_2395877" ], "modifiers": [ [ "species_10465656", "catalyst" ] ], "additional_components": [ "FBgn0037911" ] }, "reaction_10465590": { "compartment": "compartment_5460", "id": "reaction_10465590", "reactome": "R-DME-2393954", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2393945", "species_113521" ], "products": [ "species_2393950", "species_159448" ], "modifiers": [ [ "species_10465587", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VV83", "FBgn0036648" ] }, "reaction_10465664": { "compartment": "compartment_70101", "id": "reaction_10465664", "reactome": "R-DME-2395965", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395963", "species_29356" ], "products": [ "species_29372", "species_2395964" ], "modifiers": [ [ "species_10465656", "catalyst" ] ], "additional_components": [ "FBgn0037911" ] }, "reaction_10466116": { "compartment": "compartment_70101", "id": "reaction_10466116", "reactome": "R-DME-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10466110", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VMW7", "FBgn0031663" ] }, "reaction_10433331": { "compartment": "compartment_984", "id": "reaction_10433331", "reactome": "R-DME-109278", "name": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_500101" ], "products": [ "species_500104", "species_109277" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_29602", "species_76577", "species_5696194", "species_109386", "species_83927", "CHEBI:16750", "species_83908", "CHEBI:17256", "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10431539": { "compartment": "compartment_70101", "id": "reaction_10431539", "reactome": "R-DME-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10431536", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "Q9VWV5", "FBgn0052549", "species_29926" ] }, "reaction_10431553": { "compartment": "compartment_70101", "id": "reaction_10431553", "reactome": "R-DME-74258", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_30064" ], "products": [ "species_30034", "species_29408" ], "modifiers": [ [ "species_10431526", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "P10351", "FBgn0003308" ] }, "reaction_10466113": { "compartment": "compartment_70101", "id": "reaction_10466113", "reactome": "R-DME-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10466110", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VMW7", "FBgn0031663" ] }, "reaction_10465084": { "compartment": "compartment_70101", "id": "reaction_10465084", "reactome": "R-DME-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10465081", "catalyst" ] ], "additional_components": [ "P41043", "FBgn0010226", "species_29450" ] }, "reaction_10443627": { "compartment": "compartment_70101", "id": "reaction_10443627", "reactome": "R-DME-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10443624", "catalyst" ] ], "additional_components": [ "Q9VH95", "FBgn0037728", "Q9V420", "FBgn0004465" ] }, "reaction_10465079": { "compartment": "compartment_12045", "id": "reaction_10465079", "reactome": "R-DME-2161660", "name": "PGH2 is isomerised to PGE2 by PTGES", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10465076", "catalyst" ] ], "additional_components": [ "species_29450", "Q8SY19", "FBgn0025814", "Q86B54", "FBgn0053177", "X2JF29", "FBgn0053178" ] }, "reaction_10465060": { "compartment": "compartment_70101", "id": "reaction_10465060", "reactome": "R-DME-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10465057": { "compartment": "compartment_70101", "id": "reaction_10465057", "reactome": "R-DME-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10474576": { "compartment": "compartment_7660", "id": "reaction_10474576", "reactome": "R-DME-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10474566" ], "products": [ "species_5651834", "species_10474568" ], "modifiers": [ [ "species_10474573", "catalyst" ] ], "additional_components": [ "P35875", "FBgn0010247", "P35875", "FBgn0010247", "FBgn0023216" ] }, "reaction_10433082": { "compartment": "compartment_70101", "id": "reaction_10433082", "reactome": "R-DME-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10433079", "catalyst" ] ], "additional_components": [ "X2JEY5", "FBgn0052626" ] }, "reaction_10431497": { "compartment": "compartment_70101", "id": "reaction_10431497", "reactome": "R-DME-74213", "name": "Adenine + PRPP => AMP + PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_83951" ], "products": [ "species_111294", "species_76577" ], "modifiers": [ [ "species_10431494", "catalyst" ] ], "additional_components": [ "P12426", "FBgn0000109" ] }, "reaction_10465047": { "compartment": "compartment_70101", "id": "reaction_10465047", "reactome": "R-DME-2161187", "name": "N6-methyl-AMP + H2O => IMP + methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161190" ], "products": [ "species_2161177", "species_29602" ], "modifiers": [ [ "species_10465044", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VHH7", "FBgn0037661" ] }, "reaction_10433411": { "compartment": "compartment_70101", "id": "reaction_10433411", "reactome": "R-DME-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_500088", "species_29370" ], "modifiers": [ [ "species_10433408", "catalyst" ] ], "additional_components": [ "species_83908", "CHEBI:17256", "species_76577", "species_109386", "Q9VU38", "FBgn0283494", "species_29926" ] }, "reaction_10458882": { "compartment": "compartment_876", "id": "reaction_10458882", "reactome": "R-DME-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458879", "catalyst" ] ], "additional_components": [ "Q9W2L7", "FBgn0085425" ] }, "reaction_10456063": { "compartment": "compartment_70101", "id": "reaction_10456063", "reactome": "R-DME-977348", "name": "PHGHD tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29728" ], "products": [ "species_977329", "species_70106", "species_73473" ], "modifiers": [ [ "species_10456060", "catalyst" ] ], "additional_components": [ "Q9VKI8", "FBgn0032350" ] }, "reaction_10456042": { "compartment": "compartment_70101", "id": "reaction_10456042", "reactome": "R-DME-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10456039", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VSY6", "FBgn0023129" ] }, "reaction_10491958": { "compartment": "compartment_70101", "id": "reaction_10491958", "reactome": "R-DME-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10491947", "catalyst" ] ], "additional_components": [ "FBgn0028399" ] }, "reaction_10456053": { "compartment": "compartment_70101", "id": "reaction_10456053", "reactome": "R-DME-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977329", "species_29404" ], "products": [ "species_29406", "species_936706" ], "modifiers": [ [ "species_10456050", "catalyst" ] ], "additional_components": [ "Q9VAN0", "FBgn0014427" ] }, "reaction_10469871": { "compartment": "compartment_7660", "id": "reaction_10469871", "reactome": "R-DME-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469863" ], "products": [ "species_10467222", "species_10469869" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0002906", "FBgn0010602", "FBgn0002906", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469853": { "compartment": "compartment_7660", "id": "reaction_10469853", "reactome": "R-DME-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10465325" ], "products": [ "species_10467222", "species_10469851" ], "modifiers": [ [ "species_10469560", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010247", "FBgn0010602", "FBgn0010247", "FBgn0003612" ] }, "reaction_10469847": { "compartment": "compartment_7660", "id": "reaction_10469847", "reactome": "R-DME-4551738", "name": "SUMOylation of TDG with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10433855" ], "products": [ "species_10469845", "species_10467222" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0026869", "FBgn0026869", "FBgn0010602", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469893": { "compartment": "compartment_7660", "id": "reaction_10469893", "reactome": "R-DME-4570463", "name": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469883" ], "products": [ "species_10469891", "species_10467222" ], "modifiers": [ [ "species_10467488", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "FBgn0010602", "P26017", "FBgn0003042", "Q9VB08", "FBgn0003330", "Q9VHA0", "FBgn0003334", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "P39769", "FBgn0004861", "Q9VKL0", "FBgn0032330", "Q9W523", "FBgn0004860" ] }, "reaction_10469936": { "compartment": "compartment_7660", "id": "reaction_10469936", "reactome": "R-DME-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469926" ], "products": [ "species_10467222", "species_10469934" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q95RC8", "FBgn0002872", "Q9VUB7", "FBgn0052133", "FBgn0010602", "Q9VUB7", "FBgn0052133", "Q95RC8", "FBgn0002872", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469840": { "compartment": "compartment_7660", "id": "reaction_10469840", "reactome": "R-DME-4551616", "name": "SUMOylation of RPA1 (RPA70) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10427308" ], "products": [ "species_10467222", "species_10469838" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010173", "FBgn0010602", "FBgn0010173", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10435033": { "compartment": "compartment_114521", "id": "reaction_10435033", "reactome": "R-DME-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10435030", "catalyst" ] ], "additional_components": [ "species_114520", "species_74016", "P29993", "FBgn0010051" ] }, "reaction_10473205": { "compartment": "compartment_876", "id": "reaction_10473205", "reactome": "R-DME-5617178", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447516", "species_10447500" ], "products": [ "species_10473203" ], "modifiers": [], "additional_components": [ "FBgn0011676", "FBgn0259214", "Q59DP9", "FBgn0259214", "Q27571", "FBgn0011676" ] }, "reaction_10464851": { "compartment": "compartment_70101", "id": "reaction_10464851", "reactome": "R-DME-2089943", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10464846", "catalyst" ] ], "additional_components": [ "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "P83094", "Stim" ] }, "reaction_10471073": { "compartment": "compartment_12045", "id": "reaction_10471073", "reactome": "R-DME-5226904", "name": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457748", "species_10471069" ], "products": [ "species_10471071" ], "modifiers": [], "additional_components": [ "species_114520", "P29993", "FBgn0010051", "Q9VZX9", "FBgn0035371", "P50245", "FBgn0015011", "species_427523", "Q9VZX9", "FBgn0035371", "P50245", "FBgn0015011", "species_427523", "species_114520", "P29993", "FBgn0010051" ] }, "reaction_10473217": { "compartment": "compartment_70101", "id": "reaction_10473217", "reactome": "R-DME-5617179", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10473210" ], "products": [ "species_29370", "species_10473214" ], "modifiers": [ [ "species_10434289", "catalyst" ], [ "species_10473203", "catalyst" ] ], "additional_components": [ "FBgn0283471", "FBgn0283471", "Q59DP9", "FBgn0259214", "Q27571", "FBgn0011676" ] }, "reaction_10466954": { "compartment": "compartment_70101", "id": "reaction_10466954", "reactome": "R-DME-2730894", "name": "NFKB1:RELA translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10441907": { "compartment": "compartment_70101", "id": "reaction_10441907", "reactome": "R-DME-202328", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112275", "species_10441582" ], "products": [ "species_10441905" ], "modifiers": [], "additional_components": [ "FBgn0259680", "P83099", "FBgn0259680", "species_112275" ] }, "reaction_10472898": { "compartment": "compartment_70101", "id": "reaction_10472898", "reactome": "R-DME-5607724", "name": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472896" ], "products": [ "species_10437411" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q03017", "phospho-cact", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10466833": { "compartment": "compartment_70101", "id": "reaction_10466833", "reactome": "R-DME-2730835", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441891", "species_113592" ], "products": [ "species_29370", "species_10466831" ], "modifiers": [], "additional_components": [ "species_112275", "P83099", "FBgn0259680", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10458269": { "compartment": "compartment_70101", "id": "reaction_10458269", "reactome": "R-DME-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10458266", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VN95", "FBgn0037305" ] }, "reaction_10458249": { "compartment": "compartment_70101", "id": "reaction_10458249", "reactome": "R-DME-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10458246", "catalyst" ] ], "additional_components": [ "FBgn0039849" ] }, "reaction_10458279": { "compartment": "compartment_70101", "id": "reaction_10458279", "reactome": "R-DME-1237160", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_353106" ], "products": [ "species_1237165", "species_83951" ], "modifiers": [ [ "species_10458276", "catalyst" ] ], "additional_components": [ "Q9V813", "FBgn0034215" ] }, "reaction_10458259": { "compartment": "compartment_70101", "id": "reaction_10458259", "reactome": "R-DME-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10458256", "catalyst" ] ], "additional_components": [ "Q6AWN0", "FBgn0052068", "species_111793" ] }, "reaction_10455900": { "compartment": "compartment_20699", "id": "reaction_10455900", "reactome": "R-DME-975919", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_975910" ], "products": [ "species_981618" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10455845": { "compartment": "compartment_20699", "id": "reaction_10455845", "reactome": "R-DME-975903", "name": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981616" ], "modifiers": [ [ "species_10455842", "catalyst" ] ], "additional_components": [ "Q9VUH5", "FBgn0036447", "Q9VUH4", "FBgn0036446" ] }, "reaction_10455826": { "compartment": "compartment_20699", "id": "reaction_10455826", "reactome": "R-DME-975902", "name": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975925", "species_975910" ], "products": [ "species_981615" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "FBgn0035050" ] }, "reaction_10440190": { "compartment": "compartment_984", "id": "reaction_10440190", "reactome": "R-DME-192417", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171076" ], "products": [ "species_171149", "species_174602" ], "modifiers": [ [ "species_10440187", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "Q9W1B3", "FBgn0034972", "Q7KT70", "FBgn0001987", "Q9VIC7", "FBgn0051146" ] }, "reaction_10440195": { "compartment": "compartment_984", "id": "reaction_10440195", "reactome": "R-DME-192430", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10440187", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "Q9W1B3", "FBgn0034972", "Q7KT70", "FBgn0001987", "Q9VIC7", "FBgn0051146" ] }, "reaction_10440193": { "compartment": "compartment_984", "id": "reaction_10440193", "reactome": "R-DME-192425", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6814795" ], "products": [ "species_174602", "species_192438" ], "modifiers": [ [ "species_10440187", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "Q9W1B3", "FBgn0034972", "Q7KT70", "FBgn0001987", "Q9VIC7", "FBgn0051146" ] }, "reaction_10495454": { "compartment": "compartment_984", "id": "reaction_10495454", "reactome": "R-DME-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10495451", "catalyst" ] ], "additional_components": [] }, "reaction_10439518": { "compartment": "compartment_984", "id": "reaction_10439518", "reactome": "R-DME-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10439515", "catalyst" ] ], "additional_components": [ "species_964746", "O18408", "FBgn0020506", "P81641", "FBgn0000078", "P08144", "FBgn0000079" ] }, "reaction_10479867": { "compartment": "compartment_984", "id": "reaction_10479867", "reactome": "R-DME-6786421", "name": "CHIA hydrolyses chitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6786438" ], "products": [ "species_6786426", "species_6786428" ], "modifiers": [ [ "species_10479864", "catalyst" ] ], "additional_components": [ "species_1678743", "FBgn0022702" ] }, "reaction_10439525": { "compartment": "compartment_984", "id": "reaction_10439525", "reactome": "R-DME-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10439522", "catalyst" ] ], "additional_components": [ "Q9VV98", "FBgn0036659" ] }, "reaction_10479907": { "compartment": "compartment_984", "id": "reaction_10479907", "reactome": "R-DME-6786652", "name": "CHIT1 hydrolyses CHIT to 3xADGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6786654" ], "products": [ "species_6786660" ], "modifiers": [ [ "species_10479904", "catalyst" ] ], "additional_components": [ "Q8T0R7", "FBgn0064237", "Q9W303", "FBgn0026415", "Q8MM24", "FBgn0020416", "Q9VZV2", "FBgn0035398", "Q8MLZ7", "FBgn0020414", "Q9V3D4", "FBgn0020415", "Q23997", "FBgn0013763" ] }, "reaction_10439922": { "compartment": "compartment_984", "id": "reaction_10439922", "reactome": "R-DME-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189071" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10439515", "catalyst" ] ], "additional_components": [ "species_964746", "O18408", "FBgn0020506", "P81641", "FBgn0000078", "P08144", "FBgn0000079" ] }, "reaction_10491791": { "compartment": "compartment_984", "id": "reaction_10491791", "reactome": "R-DME-8878787", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8878780" ], "products": [ "species_8878776", "species_109277" ], "modifiers": [ [ "species_10491788", "catalyst" ] ], "additional_components": [ "species_1562550", "species_74016", "Q9VRM9", "FBgn0035620", "Q9VXS8", "FBgn0030661", "Q9W273", "FBgn0034712", "Q9W274", "FBgn0283480", "Q9W275", "FBgn0034710", "M9PD70", "FBgn0283479", "Q24238", "FBgn0016123", "Q7K3X8", "FBgn0033423", "Q9VDG4", "FBgn0038845", "Q9VH28", "FBgn0037786", "Q9VHD0", "FBgn0043791", "Q9VIW9", "FBgn0032779", "Q9VRM8", "FBgn0035619" ] }, "reaction_10477790": { "compartment": "compartment_70101", "id": "reaction_10477790", "reactome": "R-DME-5690827", "name": "TNFAIP3 (A20) ubiquitinates RIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454480", "species_10477782" ], "products": [ "species_10477787" ], "modifiers": [ [ "species_10477782", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734" ] }, "reaction_10477822": { "compartment": "compartment_70101", "id": "reaction_10477822", "reactome": "R-DME-5690870", "name": "OTUD7B,TNFAIP3 deubiquitinate TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477817" ], "products": [ "species_10454480", "species_10477819" ], "modifiers": [ [ "species_10477817", "catalyst" ] ], "additional_components": [ "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VH90", "FBgn0037734", "Q9W3I9", "FBgn0265464", "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734" ] }, "reaction_10479341": { "compartment": "compartment_70101", "id": "reaction_10479341", "reactome": "R-DME-6781953", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479337", "species_10471517" ], "products": [ "species_10479339" ], "modifiers": [], "additional_components": [ "FBgn0035593", "FBgn0286784", "Q7KN62", "FBgn0286784", "Q9VRJ9", "FBgn0035593" ] }, "reaction_10477802": { "compartment": "compartment_70101", "id": "reaction_10477802", "reactome": "R-DME-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477794", "species_10477798" ], "products": [ "species_10477800" ], "modifiers": [], "additional_components": [ "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q8IMZ4", "FBgn0039044", "P48148", "Rho1", "Q9W3I9", "FBgn0265464", "Q06003", "FBgn0004919", "Q8IMZ4", "FBgn0039044", "P48148", "Rho1", "Q9W3I9", "FBgn0265464", "Q9VL00", "FBgn0032214" ] }, "reaction_10479481": { "compartment": "compartment_7660", "id": "reaction_10479481", "reactome": "R-DME-6783238", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479475", "species_10479477" ], "products": [ "species_10479479" ], "modifiers": [], "additional_components": [ "Q9VL00", "FBgn0032214", "Q8WS79", "FBgn0035849", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q8WS79", "FBgn0035849", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VL00", "FBgn0032214" ] }, "reaction_10490409": { "compartment": "compartment_70101", "id": "reaction_10490409", "reactome": "R-DME-8869506", "name": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490406" ], "products": [ "species_10437507", "species_10477819" ], "modifiers": [ [ "species_10490406", "catalyst" ] ], "additional_components": [ "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VH90", "FBgn0037734", "Q9W3I9", "FBgn0265464", "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734" ] }, "reaction_10477810": { "compartment": "compartment_70101", "id": "reaction_10477810", "reactome": "R-DME-5690856", "name": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477807" ], "products": [ "species_10437507", "species_10477782" ], "modifiers": [ [ "species_10477807", "catalyst" ] ], "additional_components": [ "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734" ] }, "reaction_10479330": { "compartment": "compartment_70101", "id": "reaction_10479330", "reactome": "R-DME-6781905", "name": "ZRANB1 binds APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477812", "species_10440558" ], "products": [ "species_10479328" ], "modifiers": [], "additional_components": [ "FBgn0037734", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9VH90", "FBgn0037734" ] }, "reaction_209107": { "compartment": "compartment_70101", "id": "reaction_209107", "reactome": "R-DME-209107", "name": "Further phosphorylation of APC by DCO", "reversible": "false", "notes": "Three Serine residues in APC (APC/APC2) are further phosphorylated by DCO. Ser1504, Ser1507 (priming), and Ser1510 in Human APC are further phosphorylated by CKIepsilon.", "reactants": [ "species_113592", "species_206811" ], "products": [ "species_206735", "species_29370" ], "modifiers": [ [ "species_206811", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P18431", "sgg", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209143": { "compartment": "compartment_70101", "id": "reaction_209143", "reactome": "R-DME-209143", "name": "Phosphorylation of AXN and APC by DCO", "reversible": "false", "notes": "Axin (AXN) and APC (APC/APC2) in the 'destruction complex' are primed for phosphorylation by the CKIepsilon orthologue DCO. Ser1505 in Human APC and Ser531 in Human Axin (equivalent to Ser621 in Mouse and Ser529 in Fly) are phosphorylated.", "reactants": [ "species_113592", "species_206741" ], "products": [ "species_29370", "species_206898" ], "modifiers": [ [ "species_206741", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_209082": { "compartment": "compartment_70101", "id": "reaction_209082", "reactome": "R-DME-209082", "name": "Further phosphorylation of APC by SGG", "reversible": "false", "notes": "A Serine in APC (APC/APC2) is further phosphorylated by Shaggy (SGG). Ser1503 in Human APC is phosphorylated by GSK3beta.", "reactants": [ "species_206735", "species_113592" ], "products": [ "species_29370", "species_206602" ], "modifiers": [ [ "species_206735", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P18431", "sgg", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P18431", "sgg", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209049": { "compartment": "compartment_70101", "id": "reaction_209049", "reactome": "R-DME-209049", "name": "Phosphorylation of AXN and APC by SGG", "reversible": "false", "notes": "Additional phosphorylation of the scaffolding molecules, Axin (AXN) and APC (APC/APC2), is carried out by the GSK3beta kinase orthologue Shaggy (SGG) with Ser1501 (also a priming phosphorylation) in Human APC and Ser614 and Thr609 in Mouse Axin (equivalent to Ser522 and Thr517 respectively in Fly and Ser524 and Thr519 in Human).", "reactants": [ "species_113592", "species_206898" ], "products": [ "species_29370", "species_206811" ], "modifiers": [ [ "species_206898", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209109": { "compartment": "compartment_70101", "id": "reaction_209109", "reactome": "R-DME-209109", "name": "Further phosphorylation of ARM by SGG", "reversible": "false", "notes": "Phosphorylation of bound Armadillo (ARM) at Ser44, Ser48, and Thr52 by Shaggy (SGG) occurs.", "reactants": [ "species_113592", "species_206805" ], "products": [ "species_29370", "species_207028" ], "modifiers": [ [ "species_206805", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209134": { "compartment": "compartment_70101", "id": "reaction_209134", "reactome": "R-DME-209134", "name": "Phosphorylation of ARM by CKIalpha", "reversible": "false", "notes": "Armadillo (ARM) is primed for phosphorylation by CKIalpha at Ser56.", "reactants": [ "species_113592", "species_206666" ], "products": [ "species_29370", "species_206805" ], "modifiers": [ [ "species_206666", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209097": { "compartment": "compartment_70101", "id": "reaction_209097", "reactome": "R-DME-209097", "name": "ARM binds to APC and AXN in the 'destruction complex'", "reversible": "false", "notes": "Phosphorylated APC (APC/APC2) and Axin (AXN) are able to bind cytoplasmic Armadillo (ARM) more strongly. This now brings ARM into the 'destruction complex' and within reach of the complexed kinases.", "reactants": [ "species_205774", "species_206602" ], "products": [ "species_206666" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209133": { "compartment": "compartment_70101", "id": "reaction_209133", "reactome": "R-DME-209133", "name": "Formation of the 'destruction complex'", "reversible": "false", "notes": "The 'destruction complex' is formed from the large scaffolding proteins Axin (AXN) and APC (APC/APC2). This enables regulating molecules such as the kinases, CKIalpha, DCO, and Shaggy (SGG) and the phosphatase, PP2A to be held together in close proximity where they can regulate the phosphorylation of the scaffolding molecules and cytoplasmic Armadillo (ARM). The protein serine/threonine phosphatase PP2A is made up of the regulatory subunit A, PP2A-29B; the regulatory subunit B, Twins (TWS); and the catalytic subunit C, Microtubule star (MTS).", "reactants": [ "species_206938", "species_205716", "species_206581", "species_205729", "species_206017", "species_206210" ], "products": [ "species_206741" ], "modifiers": [], "additional_components": [ "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_10436639": { "compartment": "compartment_7660", "id": "reaction_10436639", "reactome": "R-DME-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10432514" ], "modifiers": [ [ "species_10436628", "catalyst" ] ], "additional_components": [ "Q7KTI0", "FBgn0026718", "Q9VYJ4", "FBgn0030421", "Q9VID4", "FBgn0032940", "Q9VB47", "FBgn0039509" ] }, "reaction_10436637": { "compartment": "compartment_7660", "id": "reaction_10436637", "reactome": "R-DME-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10436635" ], "modifiers": [ [ "species_10436628", "catalyst" ] ], "additional_components": [ "FBgn0033246", "Q9VID4", "FBgn0032940", "Q9VB47", "FBgn0039509" ] }, "reaction_10436630": { "compartment": "compartment_7660", "id": "reaction_10436630", "reactome": "R-DME-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10432485" ], "modifiers": [ [ "species_10436628", "catalyst" ] ], "additional_components": [ "FBgn0283427", "Q9VID4", "FBgn0032940", "Q9VB47", "FBgn0039509" ] }, "reaction_10433767": { "compartment": "compartment_70101", "id": "reaction_10433767", "reactome": "R-DME-109858", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433763", "species_10433742" ], "products": [ "species_10433765" ], "modifiers": [], "additional_components": [ "FBgn0003256", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10433796": { "compartment": "compartment_70101", "id": "reaction_10433796", "reactome": "R-DME-109864", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433789" ], "products": [ "species_10433763", "species_10433787" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "FBgn0003256" ] }, "reaction_10428216": { "compartment": "compartment_70101", "id": "reaction_10428216", "reactome": "R-DME-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29448" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10428192", "catalyst" ] ], "additional_components": [ "A1ZAA5", "FBgn0001124" ] }, "reaction_10444310": { "compartment": "compartment_70101", "id": "reaction_10444310", "reactome": "R-DME-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10444305", "catalyst" ] ], "additional_components": [ "FBgn0028646" ] }, "reaction_10479958": { "compartment": "compartment_70101", "id": "reaction_10479958", "reactome": "R-DME-6787757", "name": "PXLP-K333-GADL1 decarboxylates acidic AAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787759" ], "products": [ "species_113528", "species_6787762" ], "modifiers": [ [ "species_10479955", "catalyst" ] ], "additional_components": [ "species_1614519", "species_113553", "CHEBI:17285", "species_73590", "species_1655445", "CHEBI:15891", "Q9VPH6", "FBgn0036975", "Q24062", "FBgn0000153" ] }, "reaction_10481284": { "compartment": "compartment_70101", "id": "reaction_10481284", "reactome": "R-DME-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29642" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10481281", "catalyst" ] ], "additional_components": [ "FBgn0029689" ] }, "reaction_10428227": { "compartment": "compartment_5460", "id": "reaction_10428227", "reactome": "R-DME-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113587", "species_113552" ], "modifiers": [ [ "species_10428224", "catalyst" ] ], "additional_components": [ "Q8IPY3", "FBgn0001125" ] }, "reaction_10428195": { "compartment": "compartment_70101", "id": "reaction_10428195", "reactome": "R-DME-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_76213" ], "products": [ "species_29406", "species_29448" ], "modifiers": [ [ "species_10428192", "catalyst" ] ], "additional_components": [ "A1ZAA5", "FBgn0001124" ] }, "reaction_10460687": { "compartment": "compartment_70101", "id": "reaction_10460687", "reactome": "R-DME-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_111707", "species_29382", "species_936714" ], "modifiers": [ [ "species_10460681", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460661": { "compartment": "compartment_70101", "id": "reaction_10460661", "reactome": "R-DME-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_174369" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10460658", "catalyst" ] ], "additional_components": [ "species_71185", "Q9VRD9", "FBgn0031148" ] }, "reaction_10498480": { "compartment": "compartment_70101", "id": "reaction_10498480", "reactome": "R-DME-9679028", "name": "JAK3 binds JAK3 inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678772", "species_10453150" ], "products": [ "species_10498478" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop" ] }, "reaction_10480006": { "compartment": "compartment_70101", "id": "reaction_10480006", "reactome": "R-DME-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480000" ], "products": [ "species_10480004" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10479859": { "compartment": "compartment_70101", "id": "reaction_10479859", "reactome": "R-DME-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479790" ], "products": [ "species_10479857" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10480307": { "compartment": "compartment_17957", "id": "reaction_10480307", "reactome": "R-DME-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10480305" ], "modifiers": [ [ "species_10457732", "catalyst" ] ], "additional_components": [ "FBgn0039562", "Q24151", "Stat92E" ] }, "reaction_10480002": { "compartment": "compartment_70101", "id": "reaction_10480002", "reactome": "R-DME-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479786" ], "products": [ "species_10480000" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10479792": { "compartment": "compartment_70101", "id": "reaction_10479792", "reactome": "R-DME-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718" ], "products": [ "species_10479790" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10498451": { "compartment": "compartment_7660", "id": "reaction_10498451", "reactome": "R-DME-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498447", "species_10436122" ], "products": [ "species_10498449" ], "modifiers": [], "additional_components": [ "FBgn0037482", "FBgn0259937", "O44081", "FBgn0259937", "Q9VI74", "FBgn0037482" ] }, "reaction_169827": { "compartment": "compartment_70101", "id": "reaction_169827", "reactome": "R-DME-169827", "name": "DPDK1 phosphorylates and activates DS6K", "reversible": "false", "notes": "DPDK1 is thought to directly phosphorylate a Threonine residue in the activation loop of the p70 DS6K catalytic domain.", "reactants": [ "species_113592", "species_110503" ], "products": [ "species_29370", "species_110505" ], "modifiers": [ [ "species_110528", "catalyst" ] ], "additional_components": [] }, "reaction_110498": { "compartment": "compartment_70101", "id": "reaction_110498", "reactome": "R-DME-110498", "name": "DTOR is positively regulated by DRheb-GTP", "reversible": "false", "notes": "Insulin signaling stimulates cell growth through the conserved protein kinase DTOR (target of rapamycin). DTOR is positively regulated by DRheb-GTP by a mechanism which has yet to be deciphered although a serine residue is thought to be phosphorylated on DTOR.", "reactants": [ "species_110495", "species_113592" ], "products": [ "species_29370", "species_110497" ], "modifiers": [], "additional_components": [] }, "reaction_110485": { "compartment": "compartment_70101", "id": "reaction_110485", "reactome": "R-DME-110485", "name": "DTSC1 AND DTSC2 form a complex", "reversible": "false", "notes": "Tuberous sclerosis is a human disease caused by mutated TSC1 or TSC2 tumor repressor genes. The Drosophila equivalents form a complex and are negative regulators of TOR signaling.", "reactants": [ "species_110482", "species_110480" ], "products": [ "species_110484" ], "modifiers": [], "additional_components": [ "Q9U9A9", "TSC1", "Q9U9B0", "Phospho-DTSC2" ] }, "reaction_165127": { "compartment": "compartment_70101", "id": "reaction_165127", "reactome": "R-DME-165127", "name": "GEF binds to the inactive DRheb", "reversible": "false", "notes": "The interaction of DRheb with its guanine nucleotide exchange factor (GEF) has not been studied experimentally, but is inferred here by analogy to the very well-studied interaction of Ran GTPase with RCC1 (Azuma et al. 1999; Renault et al. 2001). GEF binds reversibly to the DRheb-GDP complex, forming a GEF:GTPase:GDP complex. Complex formation induces a change in the shape of the GTPase, substantially reducing its affinity for bound guanine nucleotide.", "reactants": [ "species_165124", "species_110416" ], "products": [ "species_165123" ], "modifiers": [], "additional_components": [ "species_29420", "Q9VND8", "Rheb", "Q95V18", "GEF", "species_29420", "Q9VND8", "Rheb" ] }, "reaction_169828": { "compartment": "compartment_70101", "id": "reaction_169828", "reactome": "R-DME-169828", "name": "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex", "reversible": "false", "notes": "DTSC2 is inactivated by DAkt1-dependent phosphorylation of residues threonine (1518) and serine (924) which is thought to destabilize DTSC2 and disrupt it's interaction with DTSC1.", "reactants": [ "species_113592", "species_110484" ], "products": [ "species_29370", "species_110480", "species_169826" ], "modifiers": [ [ "species_110466", "catalyst" ] ], "additional_components": [ "Q9U9A9", "TSC1", "Q9U9B0", "Phospho-DTSC2" ] }, "reaction_110518": { "compartment": "compartment_70101", "id": "reaction_110518", "reactome": "R-DME-110518", "name": "Activated DTOR also phosphorylates D4EBP", "reversible": "false", "notes": "DeIF4E is an initiation factor for eukaryotic translation. D4EBP forms a complex with DeIF4E, inactivating the latter. Activated DTOR phosphorylates D4EBP on a threonine residue, causing it to dissociate from DeIF4E.", "reactants": [ "species_113592", "species_110512" ], "products": [ "species_110511", "species_29370", "species_110517" ], "modifiers": [ [ "species_110497", "catalyst" ] ], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1" ] }, "reaction_165131": { "compartment": "compartment_70101", "id": "reaction_165131", "reactome": "R-DME-165131", "name": "GEF dissociates from DRheb-GTP", "reversible": "false", "notes": "The interaction of DRheb with its guanine nucleotide exchange factor (GEF) has not been studied experimentally, but is inferred here by analogy to the very well-studied interaction of Ran GTPase with RCC1 (Azuma et al. 1999; Renault et al. 2001). The GEF:DRheb-GTP complex dissociates reversibly to GEF + DRheb-GTP. The affinity of GTPase for bound nucleotide returns to its high value, so the nucleotide now stays strongly bound.", "reactants": [ "species_165125" ], "products": [ "species_110415", "species_165124" ], "modifiers": [], "additional_components": [ "Q95V18", "GEF", "species_29438", "Q9VND8", "Rheb", "species_29438", "Q9VND8", "Rheb" ] }, "reaction_110491": { "compartment": "compartment_70101", "id": "reaction_110491", "reactome": "R-DME-110491", "name": "DRheb is inhibited by the TSC1/2 complex", "reversible": "false", "notes": "The DTSC1/2 complex antagonizes the amino-acid-TOR signaling pathway. DTSC1/2 complex has a GTPase-activating protein domain (GAP). DRheb (a small GTPase called Ras homologue enriched in brain) is a target for DTSC2 GAP activity. As DRheb is a downstream effector from DTSC1/2, its inhibition by DTSC1/2 results in growth inhibition.", "reactants": [ "species_110415" ], "products": [ "species_29372", "species_110416" ], "modifiers": [ [ "species_110484", "catalyst" ] ], "additional_components": [ "species_29438", "Q9VND8", "Rheb", "species_29420", "Q9VND8", "Rheb", "Q9U9A9", "TSC1", "Q9U9B0", "Phospho-DTSC2" ] }, "reaction_165129": { "compartment": "compartment_70101", "id": "reaction_165129", "reactome": "R-DME-165129", "name": "GDP is exchanged for GTP on DRheb", "reversible": "false", "notes": "The GEF:DRheb-GDP complex freely exchanges its bound nucleotide for free nucleotide from the cytosol. Normally, the concentration of cytosolic GTP is about ten times greater than the concentration of GDP, so under physiological conditions, this exchange event favors formation of DRheb-GTP.", "reactants": [ "species_29438", "species_165123" ], "products": [ "species_29420", "species_165125" ], "modifiers": [ [ "species_165123", "catalyst" ] ], "additional_components": [ "Q95V18", "GEF", "species_29420", "Q9VND8", "Rheb", "Q95V18", "GEF", "species_29438", "Q9VND8", "Rheb", "Q95V18", "GEF", "species_29420", "Q9VND8", "Rheb" ] }, "reaction_110506": { "compartment": "compartment_70101", "id": "reaction_110506", "reactome": "R-DME-110506", "name": "Activated DTOR phosphorylates DS6K", "reversible": "false", "notes": "DTOR phosphorylates a threonine residue on DS6K, which is an important effector of cell growth.", "reactants": [ "species_113592", "species_110503" ], "products": [ "species_29370", "species_110505" ], "modifiers": [ [ "species_110497", "catalyst" ] ], "additional_components": [] }, "reaction_110437": { "compartment": "compartment_984", "id": "reaction_110437", "reactome": "R-DME-110437", "name": "DILP binds to Drosophila insulin receptor (DINR)", "reversible": "false", "notes": "Drosophila contains seven insulin-like genes which encode for DILP (Drosophila Insulin-like peptide)1-7. These DILPs can bind to the Drosophila Insulin receptor (DINR) to initiate intracellular signaling.", "reactants": [ "species_110422", "species_164721" ], "products": [ "species_110427" ], "modifiers": [], "additional_components": [ "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR" ] }, "reaction_110453": { "compartment": "compartment_70101", "id": "reaction_110453", "reactome": "R-DME-110453", "name": "Phosphorylation of PIP2 to PIP3 by Dp110", "reversible": "false", "notes": "PI3Ks are implicated in cell growth, number and size. Dp110, the Drosophila PI3K, phosphorylates PIP2 -> PIP3 (both intracellular messengers) to continue the signaling mechanism. Overexpression of Dp110 results in enlarged cell size and number suggesting a role for Dp110 in growth and size control.", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_38117" ], "modifiers": [ [ "species_110435", "catalyst" ] ], "additional_components": [ "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "O18683", "PI3K21B", "P91634", "Pi3K92E" ] }, "reaction_110468": { "compartment": "compartment_70101", "id": "reaction_110468", "reactome": "R-DME-110468", "name": "Activation of DAkt1 by DPDK1", "reversible": "false", "notes": "DPDK1 (a phosphoinositide-dependant protein kinase) controls cellular and organism growth through two effector pathways by activating DAkt and DS6K (S6 kinase). Phosphorylation of the residues Thr308 and Ser473 by DPDK1 (and another downstream kinase?) relieves intermolecular inhibition, allowing the activated DAkt to dissociate from PIP3 and modify its target, DFOXO.", "reactants": [ "species_113592", "species_110452" ], "products": [ "species_29370", "species_38117", "species_110466" ], "modifiers": [ [ "species_110528", "catalyst" ] ], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_110440": { "compartment": "compartment_70101", "id": "reaction_110440", "reactome": "R-DME-110440", "name": "Autophosphorylation of DINR", "reversible": "false", "notes": "Binding of a DILP to DINR induces a conformational change leading to autophosphorylation.", "reactants": [ "species_110427", "species_113592" ], "products": [ "species_110426", "species_29370" ], "modifiers": [ [ "species_110427", "catalyst" ] ], "additional_components": [ "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR" ] }, "reaction_164696": { "compartment": "compartment_70101", "id": "reaction_164696", "reactome": "R-DME-164696", "name": "Chico is phosphorylated", "reversible": "false", "notes": "The beta subunit of the DINR complex binds and phosphorylates Chico. Chico has 3 phosphotyrosine binding domains on residues 411, 911 and 948 where it can be phosphorylated. The tyrosine kinase function of DINR phosphorylates Chico on these domains. Phosphorylated Chico binds to SH2 domain-containing proteins such as PI3K (Phosphoinositide 3-Kinase).", "reactants": [ "species_110430", "species_113592" ], "products": [ "species_29370", "species_164707" ], "modifiers": [ [ "species_110430", "catalyst" ] ], "additional_components": [ "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico", "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico" ] }, "reaction_110459": { "compartment": "compartment_70101", "id": "reaction_110459", "reactome": "R-DME-110459", "name": "PIP3 dephosphorylated to PIP2 by DPTEN", "reversible": "false", "notes": "DPTEN (a phosphoinositide phosphatase) catalyses the reversal of PIP3 to PIP2. This mechanism, together with Dp110 activity, regulates the levels of PIP3 which is the second messenger for controlling organism size.", "reactants": [ "species_38117" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_110456", "catalyst" ] ], "additional_components": [] }, "reaction_110475": { "compartment": "compartment_70101", "id": "reaction_110475", "reactome": "R-DME-110475", "name": "DAkt1-mediated phosphorylation inactivates DFOXO", "reversible": "false", "notes": "DFOXO belongs to the FOXO subfamily of forkhead transcription factors. The FOXO factors regulate genes involved in cell cycle control, cell death and stress responses. Phosphorylation of DFOXO by DAkt1 on three residues (Thr44, Ser190 and Ser259) leads to its cytoplasmic retention and inactivation, inhibiting expression of DFOXO-regulated genes. These include D4EBP, DInR and Chico.", "reactants": [ "species_113592", "species_110472" ], "products": [ "species_110474", "species_29370" ], "modifiers": [ [ "species_110466", "catalyst" ] ], "additional_components": [] }, "reaction_110442": { "compartment": "compartment_70101", "id": "reaction_110442", "reactome": "R-DME-110442", "name": "Activated DINR binds Chico", "reversible": "false", "notes": "The Drosophila homologue to mammalian IRS1-4 (Insulin Receptor Substrate), Chico, binds to the beta subunit of DINR. Chico is an adaptor protein that interacts with the activated drosophila insulin-like receptor (DINR), allowing signaling molecules to attach and signal to downstream effectors.", "reactants": [ "species_110429", "species_110426" ], "products": [ "species_110430" ], "modifiers": [], "additional_components": [ "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico" ] }, "reaction_110463": { "compartment": "compartment_70101", "id": "reaction_110463", "reactome": "R-DME-110463", "name": "Increased PIP3 levels recruit DAkt1 to the membrane", "reversible": "false", "notes": "DAkt (a protein kinase B) is recruited to the plasma membrane due to the interaction between its PH (pleckstrin homology) domain and PIP3. In Drosophila, DAkt appears to be the only target activated by increased PIP3 levels.", "reactants": [ "species_110462", "species_38117" ], "products": [ "species_110452" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_110446": { "compartment": "compartment_70101", "id": "reaction_110446", "reactome": "R-DME-110446", "name": "Phospho-Chico: Activated DINR binds p60:Dp110", "reversible": "false", "notes": "The Phospho-Chico: Activated DINR in the plasma membrane binds to cytosolic p60:p110. The p60 subunit of the latter complex mediates this interaction; the p110 subunit is the Drosophila PI3K. This complex is an active protein kinase whose direct and indirect targets include PIP2, annotated here.", "reactants": [ "species_110434", "species_164707" ], "products": [ "species_110435" ], "modifiers": [], "additional_components": [ "O18683", "PI3K21B", "P91634", "Pi3K92E", "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "O18683", "PI3K21B", "P91634", "Pi3K92E" ] }, "reaction_10461117": { "compartment": "compartment_172574", "id": "reaction_10461117", "reactome": "R-DME-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_1806198", "species_29370" ], "modifiers": [ [ "species_10461070", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099", "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10461137": { "compartment": "compartment_172574", "id": "reaction_10461137", "reactome": "R-DME-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10461006", "catalyst" ] ], "additional_components": [ "Q8MLR7", "FBgn0028497", "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10461009": { "compartment": "compartment_172574", "id": "reaction_10461009", "reactome": "R-DME-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10461006", "catalyst" ] ], "additional_components": [ "Q8MLR7", "FBgn0028497", "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10445980": { "compartment": "compartment_12045", "id": "reaction_10445980", "reactome": "R-DME-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445976" ], "products": [ "species_10445962" ], "modifiers": [], "additional_components": [ "FBgn0033010", "FBgn0033010" ] }, "reaction_10445916": { "compartment": "compartment_70101", "id": "reaction_10445916", "reactome": "R-DME-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445912" ], "products": [ "species_10445914" ], "modifiers": [], "additional_components": [ "FBgn0033010", "FBgn0033010" ] }, "reaction_10447719": { "compartment": "compartment_20699", "id": "reaction_10447719", "reactome": "R-DME-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445964" ], "products": [ "species_10445912", "species_10447711" ], "modifiers": [ [ "species_10447716", "catalyst" ] ], "additional_components": [ "FBgn0033010", "FBgn0033010", "FBgn0033010", "FBgn0033656" ] }, "reaction_10445974": { "compartment": "compartment_20699", "id": "reaction_10445974", "reactome": "R-DME-381135", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445962" ], "products": [ "species_10445964", "species_10445966" ], "modifiers": [ [ "species_10445971", "catalyst" ] ], "additional_components": [ "FBgn0033010", "FBgn0033010", "FBgn0033010", "FBgn0037105" ] }, "reaction_209303": { "compartment": "compartment_13231", "id": "reaction_209303", "reactome": "R-DME-209303", "name": "LGS transports from the nucleus to the cytosol", "reversible": "false", "notes": "The free Legless (LGS) protein exports from the nucleus to the cytoplasm by an unknown mechanism potentially with additional interaction partners, where it can now target Armadillo (ARM), which is now not being rapidly removed from the cytoplasm by the 'destruction complex'.", "reactants": [ "species_205826" ], "products": [ "species_205724" ], "modifiers": [], "additional_components": [] }, "reaction_209332": { "compartment": "compartment_7660", "id": "reaction_209332", "reactome": "R-DME-209332", "name": "LGS dissociates from the PYGO complex", "reversible": "false", "notes": "The inactivation and destabilisation of the 'destruction complex' means elevated levels of cytoplasmic Armadillo (ARM). In the nucleus, the protein Legless (LGS) dissociates from its nuclear anchor, Pygopus (PYGO).", "reactants": [ "species_206853" ], "products": [ "species_205990", "species_205826" ], "modifiers": [], "additional_components": [ "Q961D9", "LGS", "Q9V9W8", "PYGO" ] }, "reaction_209371": { "compartment": "compartment_70101", "id": "reaction_209371", "reactome": "R-DME-209371", "name": "LGS binds to ARM", "reversible": "false", "notes": "The targeted free cytoplasmic Armadillo (ARM) is complexed to Legless (LGS).", "reactants": [ "species_205724", "species_205774" ], "products": [ "species_206796" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q961D9", "LGS" ] }, "reaction_209177": { "compartment": "compartment_13231", "id": "reaction_209177", "reactome": "R-DME-209177", "name": "LGS:ARM complex transports from the cytosol to the nucleus", "reversible": "false", "notes": "The Legless:Armadillo (LGS:ARM) complex is imported to the nucleus by an unknown mechanism which may include additional interaction partners.", "reactants": [ "species_206796" ], "products": [ "species_206839" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q961D9", "LGS", "Q961D9", "LGS", "P18824", "arm" ] }, "reaction_10461167": { "compartment": "compartment_12045", "id": "reaction_10461167", "reactome": "R-DME-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806234" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10461164", "catalyst" ] ], "additional_components": [ "FBgn0283500" ] }, "reaction_10461022": { "compartment": "compartment_12045", "id": "reaction_10461022", "reactome": "R-DME-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10461019", "catalyst" ] ], "additional_components": [ "M9PDM4", "FBgn0267350", "Q9VND3", "FBgn0037339" ] }, "reaction_10486803": { "compartment": "compartment_70101", "id": "reaction_10486803", "reactome": "R-DME-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486799", "species_10460994" ], "products": [ "species_10486801" ], "modifiers": [], "additional_components": [ "FBgn0025802", "FBgn0025742", "Q9VMI9", "FBgn0025742", "Q9VGH9", "FBgn0025802" ] }, "reaction_10486806": { "compartment": "compartment_70101", "id": "reaction_10486806", "reactome": "R-DME-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10486801", "catalyst" ] ], "additional_components": [ "Q9VMI9", "FBgn0025742", "Q9VGH9", "FBgn0025802" ] }, "reaction_10486809": { "compartment": "compartment_70101", "id": "reaction_10486809", "reactome": "R-DME-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10486801", "catalyst" ] ], "additional_components": [ "Q9VMI9", "FBgn0025742", "Q9VGH9", "FBgn0025802" ] }, "reaction_10486896": { "compartment": "compartment_172574", "id": "reaction_10486896", "reactome": "R-DME-6810392", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486892" ], "products": [ "species_10486894" ], "modifiers": [], "additional_components": [ "FBgn0036058", "FBgn0036058" ] }, "reaction_10486899": { "compartment": "compartment_7660", "id": "reaction_10486899", "reactome": "R-DME-6810410", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_6810412" ], "products": [ "species_6810408", "species_113550" ], "modifiers": [ [ "species_10486894", "catalyst" ] ], "additional_components": [ "FBgn0036058" ] }, "reaction_10487163": { "compartment": "compartment_7660", "id": "reaction_10487163", "reactome": "R-DME-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_29358" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10487160", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924" ] }, "reaction_10461051": { "compartment": "compartment_20699", "id": "reaction_10461051", "reactome": "R-DME-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10461048", "catalyst" ] ], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "A0A4D6K881", "FBgn0004373" ] }, "reaction_10461210": { "compartment": "compartment_20699", "id": "reaction_10461210", "reactome": "R-DME-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10461207", "catalyst" ] ], "additional_components": [ "M9PDM4", "FBgn0267350", "Q9VND3", "FBgn0037339" ] }, "reaction_10461162": { "compartment": "compartment_20699", "id": "reaction_10461162", "reactome": "R-DME-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806159" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10461159", "catalyst" ] ], "additional_components": [ "FBgn0283500" ] }, "reaction_10461094": { "compartment": "compartment_20699", "id": "reaction_10461094", "reactome": "R-DME-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10461070", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099", "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10461062": { "compartment": "compartment_20699", "id": "reaction_10461062", "reactome": "R-DME-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10461059", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926" ] }, "reaction_10461188": { "compartment": "compartment_20699", "id": "reaction_10461188", "reactome": "R-DME-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461186", "species_10461046" ], "products": [ "species_10461048" ], "modifiers": [], "additional_components": [ "FBgn0004373", "P61209", "FBgn0010348", "species_29438", "P61209", "FBgn0010348", "species_29438", "A0A4D6K881", "FBgn0004373" ] }, "reaction_10461027": { "compartment": "compartment_20699", "id": "reaction_10461027", "reactome": "R-DME-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10461024", "catalyst" ] ], "additional_components": [ "FBgn0023508" ] }, "reaction_10461170": { "compartment": "compartment_20699", "id": "reaction_10461170", "reactome": "R-DME-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10461159", "catalyst" ] ], "additional_components": [ "FBgn0283500" ] }, "reaction_10490964": { "compartment": "compartment_437051", "id": "reaction_10490964", "reactome": "R-DME-8874470", "name": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8874484" ], "products": [ "species_8874460" ], "modifiers": [ [ "species_10490961", "catalyst" ] ], "additional_components": [ "species_179838", "species_179856", "species_179856", "species_179838", "Q7KVH9", "FBgn0034894" ] }, "reaction_10461198": { "compartment": "compartment_171062", "id": "reaction_10461198", "reactome": "R-DME-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806238" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10486787": { "compartment": "compartment_70101", "id": "reaction_10486787", "reactome": "R-DME-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486783", "species_10460992" ], "products": [ "species_10486785" ], "modifiers": [], "additional_components": [ "FBgn0030582", "FBgn0025742", "Q9VMI9", "FBgn0025742", "Q9VY15", "FBgn0030582" ] }, "reaction_10461145": { "compartment": "compartment_171062", "id": "reaction_10461145", "reactome": "R-DME-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10461142", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10461176": { "compartment": "compartment_171062", "id": "reaction_10461176", "reactome": "R-DME-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10461142", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10486791": { "compartment": "compartment_70101", "id": "reaction_10486791", "reactome": "R-DME-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486783", "species_10460994" ], "products": [ "species_10486789" ], "modifiers": [], "additional_components": [ "FBgn0030582", "FBgn0025742", "Q9VMI9", "FBgn0025742", "Q9VY15", "FBgn0030582" ] }, "reaction_10461096": { "compartment": "compartment_171062", "id": "reaction_10461096", "reactome": "R-DME-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_1806180", "species_29370" ], "modifiers": [ [ "species_10460982", "catalyst" ] ], "additional_components": [ "FBgn0037339" ] }, "reaction_10488313": { "compartment": "compartment_70101", "id": "reaction_10488313", "reactome": "R-DME-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_29372", "species_8849958" ], "modifiers": [ [ "species_10488310", "catalyst" ] ], "additional_components": [ "species_179838", "species_202247", "species_179856", "species_1806198", "species_1806289", "species_1806212", "FBgn0038890" ] }, "reaction_10486794": { "compartment": "compartment_171062", "id": "reaction_10486794", "reactome": "R-DME-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10486785", "catalyst" ] ], "additional_components": [ "Q9VMI9", "FBgn0025742", "Q9VY15", "FBgn0030582" ] }, "reaction_10461073": { "compartment": "compartment_171062", "id": "reaction_10461073", "reactome": "R-DME-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10461070", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099", "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10461216": { "compartment": "compartment_171062", "id": "reaction_10461216", "reactome": "R-DME-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_29370", "species_1806238" ], "modifiers": [ [ "species_10461055", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926" ] }, "reaction_10487317": { "compartment": "compartment_12045", "id": "reaction_10487317", "reactome": "R-DME-6814254", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6814253" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10487314", "catalyst" ] ], "additional_components": [ "FBgn0003656" ] }, "reaction_10487177": { "compartment": "compartment_876", "id": "reaction_10487177", "reactome": "R-DME-6813740", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6813734" ], "products": [ "species_426910", "species_76114" ], "modifiers": [ [ "species_10487174", "catalyst" ] ], "additional_components": [ "FBgn0038432" ] }, "reaction_10441150": { "compartment": "compartment_70101", "id": "reaction_10441150", "reactome": "R-DME-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10441147", "catalyst" ] ], "additional_components": [] }, "reaction_10461181": { "compartment": "compartment_876", "id": "reaction_10461181", "reactome": "R-DME-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10461178", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924", "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461213": { "compartment": "compartment_876", "id": "reaction_10461213", "reactome": "R-DME-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10461112", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q5U0V7", "FBgn0034691", "A1ZAS8", "FBgn0027506", "Q8MLR7", "FBgn0028497", "Q9VMI9", "FBgn0025742" ] }, "reaction_10461115": { "compartment": "compartment_876", "id": "reaction_10461115", "reactome": "R-DME-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10461112", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q5U0V7", "FBgn0034691", "A1ZAS8", "FBgn0027506", "Q8MLR7", "FBgn0028497", "Q9VMI9", "FBgn0025742" ] }, "reaction_10460987": { "compartment": "compartment_876", "id": "reaction_10460987", "reactome": "R-DME-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10460982", "catalyst" ] ], "additional_components": [ "FBgn0037339" ] }, "reaction_10460951": { "compartment": "compartment_876", "id": "reaction_10460951", "reactome": "R-DME-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461205": { "compartment": "compartment_876", "id": "reaction_10461205", "reactome": "R-DME-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10461202", "catalyst" ] ], "additional_components": [ "Q5U0V7", "FBgn0034691", "M9PHS8", "FBgn0030761", "Q7K161", "FBgn0034179" ] }, "reaction_10461173": { "compartment": "compartment_876", "id": "reaction_10461173", "reactome": "R-DME-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_1806224", "species_29370" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461140": { "compartment": "compartment_876", "id": "reaction_10461140", "reactome": "R-DME-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461012": { "compartment": "compartment_876", "id": "reaction_10461012", "reactome": "R-DME-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_1806240", "species_29370" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10486766": { "compartment": "compartment_70101", "id": "reaction_10486766", "reactome": "R-DME-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486762", "species_10486757" ], "products": [ "species_10486764" ], "modifiers": [], "additional_components": [ "FBgn0035945", "FBgn0028497", "Q8MLR7", "FBgn0028497", "Q8SZY7", "FBgn0035945" ] }, "reaction_10460977": { "compartment": "compartment_876", "id": "reaction_10460977", "reactome": "R-DME-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10460974", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924" ] }, "reaction_10461200": { "compartment": "compartment_876", "id": "reaction_10461200", "reactome": "R-DME-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10461039": { "compartment": "compartment_876", "id": "reaction_10461039", "reactome": "R-DME-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10461036", "catalyst" ] ], "additional_components": [ "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10461134": { "compartment": "compartment_876", "id": "reaction_10461134", "reactome": "R-DME-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10461131", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10486770": { "compartment": "compartment_70101", "id": "reaction_10486770", "reactome": "R-DME-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461105", "species_10486762" ], "products": [ "species_10486768" ], "modifiers": [], "additional_components": [ "FBgn0028497", "FBgn0035945", "Q8SZY7", "FBgn0035945", "Q8MLR7", "FBgn0028497" ] }, "reaction_10461099": { "compartment": "compartment_876", "id": "reaction_10461099", "reactome": "R-DME-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10461036", "catalyst" ] ], "additional_components": [ "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10490903": { "compartment": "compartment_20699", "id": "reaction_10490903", "reactome": "R-DME-8870499", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444044", "species_10490899", "species_1806217" ], "products": [ "species_10490901" ], "modifiers": [], "additional_components": [ "FBgn0010348", "FBgn0030641", "species_392417", "Q9VXV1", "FBgn0030641", "P61209", "FBgn0010348" ] }, "reaction_10486775": { "compartment": "compartment_876", "id": "reaction_10486775", "reactome": "R-DME-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10486772", "catalyst" ] ], "additional_components": [ "Q8SZY7", "FBgn0035945", "Q8MLR7", "FBgn0028497" ] }, "reaction_10486778": { "compartment": "compartment_876", "id": "reaction_10486778", "reactome": "R-DME-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10486772", "catalyst" ] ], "additional_components": [ "Q8SZY7", "FBgn0035945", "Q8MLR7", "FBgn0028497" ] }, "reaction_10461092": { "compartment": "compartment_876", "id": "reaction_10461092", "reactome": "R-DME-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_202247" ], "modifiers": [ [ "species_10461089", "catalyst" ] ], "additional_components": [ "M9PHS8", "FBgn0030761", "Q7K161", "FBgn0034179" ] }, "reaction_10461154": { "compartment": "compartment_876", "id": "reaction_10461154", "reactome": "R-DME-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10461151", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099" ] }, "reaction_10461184": { "compartment": "compartment_876", "id": "reaction_10461184", "reactome": "R-DME-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10441147", "catalyst" ] ], "additional_components": [] }, "reaction_10446383": { "compartment": "compartment_876", "id": "reaction_10446383", "reactome": "R-DME-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592" ], "products": [ "species_29372", "species_29370", "species_425425" ], "modifiers": [ [ "species_10446380", "catalyst" ] ], "additional_components": [ "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793" ] }, "reaction_10471103": { "compartment": "compartment_70101", "id": "reaction_10471103", "reactome": "R-DME-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430457", "species_10471099" ], "products": [ "species_10471101" ], "modifiers": [], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "FBgn0030321", "Q9VYW4", "FBgn0030321", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926" ] }, "reaction_10487844": { "compartment": "compartment_70101", "id": "reaction_10487844", "reactome": "R-DME-8848053", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_8848047" ], "products": [ "species_29372", "species_176478", "species_29370" ], "modifiers": [ [ "species_10487841", "catalyst" ] ], "additional_components": [ "FBgn0263747" ] }, "reaction_10446297": { "compartment": "compartment_17947", "id": "reaction_10446297", "reactome": "R-DME-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10446294", "catalyst" ] ], "additional_components": [ "Q7JUN3", "FBgn0039890", "Q9VWC8", "FBgn0031069" ] }, "reaction_10446328": { "compartment": "compartment_17947", "id": "reaction_10446328", "reactome": "R-DME-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446326", "species_10446302" ], "products": [ "species_10446324", "species_10446294", "species_10446302" ], "modifiers": [], "additional_components": [ "Q9VWC8", "FBgn0031069", "Q7JUN3", "FBgn0039890", "Q8IP97", "FBgn0032407", "FBgn0036484", "FBgn0032407", "Q7JUN3", "FBgn0039890", "Q9VWC8", "FBgn0031069", "FBgn0036484" ] }, "reaction_10459304": { "compartment": "compartment_70101", "id": "reaction_10459304", "reactome": "R-DME-1454928", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_29356", "species_113592" ], "products": [ "species_171149", "species_29372", "species_29370" ], "modifiers": [ [ "species_10459301", "catalyst" ] ], "additional_components": [ "Q9VQY4", "FBgn0020762" ] }, "reaction_10443719": { "compartment": "compartment_876", "id": "reaction_10443719", "reactome": "R-DME-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265784", "species_113592" ], "products": [ "species_29372", "species_29370", "species_265781" ], "modifiers": [ [ "species_10443716", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_8848047", "CHEBI:26125", "species_8848047", "P45843", "FBgn0003515", "P12428", "FBgn0000241", "Q0KI14", "FBgn0051121", "Q8MRJ2", "FBgn0039244" ] }, "reaction_10443895": { "compartment": "compartment_876", "id": "reaction_10443895", "reactome": "R-DME-266082", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_216762", "species_113592" ], "products": [ "species_29372", "species_29370", "species_171095" ], "modifiers": [ [ "species_10443892", "catalyst" ] ], "additional_components": [ "Q0E8U2", "FBgn0031515", "Q8T9E6", "FBgn0264494", "Q9VQY4", "FBgn0020762", "M9PBX3", "FBgn0031449", "Q8MRL3", "FBgn0031516", "Q9VPJ7", "FBgn0031220", "Q8IPV3", "FBgn0025683", "Q9VL61", "FBgn0032167", "Q9VTL3", "FBgn0052091" ] }, "reaction_10476387": { "compartment": "compartment_2133233", "id": "reaction_10476387", "reactome": "R-DME-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5684863" ], "products": [ "species_29372", "species_29370", "species_5684869" ], "modifiers": [ [ "species_10476384", "catalyst" ] ], "additional_components": [ "species_429802", "species_8954401", "species_429802", "species_8954401", "FBgn0031170" ] }, "reaction_10459119": { "compartment": "compartment_17906", "id": "reaction_10459119", "reactome": "R-DME-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10459116", "catalyst" ] ], "additional_components": [ "Q9VF20", "FBgn0038376" ] }, "reaction_10446272": { "compartment": "compartment_70616", "id": "reaction_10446272", "reactome": "R-DME-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_189444", "species_113521" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10446269", "catalyst" ] ], "additional_components": [ "Q9W0C5", "FBgn0035244" ] }, "reaction_10476235": { "compartment": "compartment_70101", "id": "reaction_10476235", "reactome": "R-DME-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_352022" ], "products": [ "species_188972", "species_29372", "species_29370" ], "modifiers": [ [ "species_10446380", "catalyst" ] ], "additional_components": [ "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793" ] }, "reaction_10471050": { "compartment": "compartment_70101", "id": "reaction_10471050", "reactome": "R-DME-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5223341" ], "products": [ "species_5223344", "species_29372", "species_29370" ], "modifiers": [ [ "species_10471047", "catalyst" ] ], "additional_components": [ "Q5BI62", "FBgn0010241" ] }, "reaction_10490055": { "compartment": "compartment_876", "id": "reaction_10490055", "reactome": "R-DME-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489992" ], "products": [ "species_10446380" ], "modifiers": [], "additional_components": [ "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793" ] }, "reaction_10459319": { "compartment": "compartment_876", "id": "reaction_10459319", "reactome": "R-DME-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1131652" ], "products": [ "species_29372", "species_29370", "species_1467459" ], "modifiers": [ [ "species_10459316", "catalyst" ] ], "additional_components": [ "Q86B52", "FBgn0263747", "X2JG15", "FBgn0083956" ] }, "reaction_10490041": { "compartment": "compartment_12045", "id": "reaction_10490041", "reactome": "R-DME-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490038", "species_10426987" ], "products": [ "species_10490036" ], "modifiers": [ [ "species_10490038", "catalyst" ] ], "additional_components": [ "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VKC7", "FBgn0032398", "Q9V415", "FBgn0028475", "Q9VXP1", "FBgn0030693", "Q9VFY3", "FBgn0038125", "Q8IQM1", "FBgn0052847", "Q8IR26", "FBgn0052581", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VKC7", "FBgn0032398", "Q9V415", "FBgn0028475", "Q9VXP1", "FBgn0030693", "Q9VFY3", "FBgn0038125", "Q8IQM1", "FBgn0052847", "Q8IR26", "FBgn0052581", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VKC7", "FBgn0032398", "Q9V415", "FBgn0028475", "Q9VXP1", "FBgn0030693", "Q9VFY3", "FBgn0038125", "Q8IQM1", "FBgn0052847", "Q8IR26", "FBgn0052581", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207" ] }, "reaction_10490043": { "compartment": "compartment_70101", "id": "reaction_10490043", "reactome": "R-DME-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489994" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10459297": { "compartment": "compartment_70101", "id": "reaction_10459297", "reactome": "R-DME-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1454930" ], "products": [ "species_29372", "species_29370", "species_1454919" ], "modifiers": [ [ "species_10459294", "catalyst" ] ], "additional_components": [ "Q9VLN6", "FBgn0032026", "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793", "Q9VLP5", "FBgn0032018", "Q9VL32", "FBgn0028675", "Q7KTC0", "FBgn0032456" ] }, "reaction_10463004": { "compartment": "compartment_984", "id": "reaction_10463004", "reactome": "R-DME-2022141", "name": "Prolysyl oxidase activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462952" ], "products": [ "species_10462980", "species_10463002" ], "modifiers": [ [ "species_10462626", "catalyst" ] ], "additional_components": [ "Q9W2C9", "FBgn0034660", "Q9V9X5", "FBgn0039848", "Q9W2C9", "FBgn0034660", "Q9V9X5", "FBgn0039848", "Q9W2C9", "FBgn0034660", "Q9V9X5", "FBgn0039848", "Q9VC47", "FBgn0004885", "P25723", "FBgn0003719" ] }, "reaction_10465381": { "compartment": "compartment_984", "id": "reaction_10465381", "reactome": "R-DME-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459394" ], "products": [ "species_10465379" ], "modifiers": [], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10459396": { "compartment": "compartment_984", "id": "reaction_10459396", "reactome": "R-DME-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459392" ], "products": [ "species_10459394" ], "modifiers": [], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10433228": { "compartment": "compartment_5460", "id": "reaction_10433228", "reactome": "R-DME-77345", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77308", "species_113596" ], "products": [ "species_77343", "species_31649" ], "modifiers": [ [ "species_10433219", "catalyst" ] ], "additional_components": [ "Q9VSA3", "FBgn0035811" ] }, "reaction_10433226": { "compartment": "compartment_5460", "id": "reaction_10433226", "reactome": "R-DME-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10494966": { "compartment": "compartment_5460", "id": "reaction_10494966", "reactome": "R-DME-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10494963", "catalyst" ] ], "additional_components": [ "Q9V6U9", "FBgn0033883" ] }, "reaction_10433224": { "compartment": "compartment_5460", "id": "reaction_10433224", "reactome": "R-DME-77340", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77339" ], "products": [ "species_77337", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_390061": { "compartment": "compartment_70101", "id": "reaction_390061", "reactome": "R-DME-390061", "name": "YKI binds to phosphorylated WTS", "reversible": "false", "notes": "The transcriptional factor Yorkie (YKI) via it's two WW domains binds to activated Warts (WTS) kinase. However, it appears that this particular binding has no detectable influence on YKI phosphorylation.", "reactants": [ "species_390114", "species_390068" ], "products": [ "species_390067" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q45VV3", "yki", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390044": { "compartment": "compartment_70101", "id": "reaction_390044", "reactome": "R-DME-390044", "name": "YKI is phosphorylated by and then dissociates from phosphorylated WTS", "reversible": "false", "notes": "The transcription factor Yorkie (YKI) is phosphorylated at Ser111, Ser168 and Ser250 by the activated serine/threonine kinase Warts (WTS).", "reactants": [ "species_113592", "species_390067" ], "products": [ "species_29370", "species_390064", "species_390068" ], "modifiers": [ [ "species_390067", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q45VV3", "yki", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q45VV3", "yki", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390078": { "compartment": "compartment_70101", "id": "reaction_390078", "reactome": "R-DME-390078", "name": "14-3-3 dimer binds to phosphorylated YKI", "reversible": "false", "notes": "The phosphorylated transcription factor Yorkie (YKI) associates with either one of the two 14-3-3 dimer isoforms (14-3-3epsilon or 14-3-3zeta). This effectively anchors YKI in the cytosol and prevents it entering the nucleus to activate its target genes.", "reactants": [ "species_390066", "species_390064" ], "products": [ "species_390163" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "P29310", "14-3-3zeta", "Q45VV3", "yki", "P92177", "14-3-3epsilon", "P29310", "14-3-3zeta" ] }, "reaction_10450831": { "compartment": "compartment_70101", "id": "reaction_10450831", "reactome": "R-DME-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450827" ], "products": [ "species_113592", "species_10450825" ], "modifiers": [], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "species_113592", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563" ] }, "reaction_10495569": { "compartment": "compartment_70101", "id": "reaction_10495569", "reactome": "R-DME-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10495566", "catalyst" ] ], "additional_components": [ "Q8IRI6", "FBgn0264574" ] }, "reaction_10450829": { "compartment": "compartment_70101", "id": "reaction_10450829", "reactome": "R-DME-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10450825" ], "products": [ "species_10450827" ], "modifiers": [], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "species_113592" ] }, "reaction_10495571": { "compartment": "compartment_70101", "id": "reaction_10495571", "reactome": "R-DME-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10439537", "catalyst" ] ], "additional_components": [ "Q8IRI6", "FBgn0264574" ] }, "reaction_10448859": { "compartment": "compartment_876", "id": "reaction_10448859", "reactome": "R-DME-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10448856", "catalyst" ] ], "additional_components": [ "A8JQU1", "FBgn0037386", "Q9VQP0", "FBgn0053282", "A0A1Z1CGZ4", "FBgn0037485", "Q7K2U8", "FBgn0028560", "Q9VQN6", "FBgn0031517", "Q7JVN6", "FBgn0037387", "Q9VI79", "FBgn0037486", "Q9W3S8", "FBgn0029932", "P53403", "FBgn0015230", "Q8MLQ7", "FBgn0034909", "Q9VU17", "FBgn0036316", "Q8MKK4", "FBgn0033644", "Q9VQP2", "FBgn0031523", "A1ZA52", "FBgn0034045", "Q8IPZ9", "FBgn0053282", "Q9VQP1", "FBgn0031522", "A1Z8N1", "FBgn0050035", "Q7K3P6", "FBgn0034247" ] }, "reaction_10495557": { "compartment": "compartment_70101", "id": "reaction_10495557", "reactome": "R-DME-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10495554", "catalyst" ] ], "additional_components": [ "Q0IGX4", "FBgn0033047", "Q7KJP2", "FBgn0028561", "Q7KK97", "FBgn0028563", "Q9U622", "FBgn0028562" ] }, "reaction_10471641": { "compartment": "compartment_70101", "id": "reaction_10471641", "reactome": "R-DME-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10450825", "catalyst" ], [ "species_10471639", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "FBgn0014135" ] }, "reaction_10448729": { "compartment": "compartment_876", "id": "reaction_10448729", "reactome": "R-DME-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10448724", "catalyst" ] ], "additional_components": [ "species_964746", "species_29532", "species_964746", "species_29532", "FBgn0264574" ] }, "reaction_10448760": { "compartment": "compartment_876", "id": "reaction_10448760", "reactome": "R-DME-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10448757", "catalyst" ] ], "additional_components": [ "species_964746", "species_30034", "species_29532", "species_964746", "species_30034", "species_29532", "FBgn0264574" ] }, "reaction_10495562": { "compartment": "compartment_70101", "id": "reaction_10495562", "reactome": "R-DME-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10495559", "catalyst" ] ], "additional_components": [ "Q7KK97", "FBgn0028563" ] }, "reaction_10450834": { "compartment": "compartment_70101", "id": "reaction_10450834", "reactome": "R-DME-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10439537", "catalyst" ] ], "additional_components": [ "Q8IRI6", "FBgn0264574" ] }, "reaction_10448879": { "compartment": "compartment_876", "id": "reaction_10448879", "reactome": "R-DME-429594", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_264638", "species_74113" ], "products": [ "species_264618", "species_83910", "species_352022" ], "modifiers": [ [ "species_10448876", "catalyst" ] ], "additional_components": [ "FBgn0038641" ] }, "reaction_10449996": { "compartment": "compartment_876", "id": "reaction_10449996", "reactome": "R-DME-444120", "name": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_266029", "species_74113" ], "products": [ "species_83910", "species_352022", "species_29424" ], "modifiers": [ [ "species_10449993", "catalyst" ] ], "additional_components": [ "Q7K330", "FBgn0033443", "A1ZBC7", "FBgn0034381", "Q9VSV2", "FBgn0035969", "A1Z8V9", "FBgn0033708", "Q9VLY6", "FBgn0267326", "Q9VLY5", "FBgn0031935", "Q9VLY4", "FBgn0031936", "Q9VLY3", "FBgn0031937", "Q9VJR4", "FBgn0028886", "Q7KTJ8", "FBgn0053296", "Q9W4C5", "FBgn0029762", "Q9W1J0", "FBgn0034911" ] }, "reaction_10449963": { "compartment": "compartment_876", "id": "reaction_10449963", "reactome": "R-DME-444100", "name": "PROT mediates L-proline uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_352033", "species_74113" ], "products": [ "species_83910", "species_113538", "species_352022" ], "modifiers": [ [ "species_10449960", "catalyst" ] ], "additional_components": [ "Q9VLY5", "FBgn0031935", "Q9VLY4", "FBgn0031936", "Q9VLY3", "FBgn0031937", "Q9VJR4", "FBgn0028886", "Q7KTJ8", "FBgn0053296", "Q9W4C5", "FBgn0029762", "Q7K330", "FBgn0033443", "Q9W1J0", "FBgn0034911", "A1ZBC7", "FBgn0034381", "Q9VSV2", "FBgn0035969", "A1Z8V9", "FBgn0033708", "Q9VLY6", "FBgn0267326" ] }, "reaction_10444219": { "compartment": "compartment_876", "id": "reaction_10444219", "reactome": "R-DME-352059", "name": "SLC6A15-mediated amino acid uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352051", "species_74113" ], "products": [ "species_83910", "species_352048" ], "modifiers": [ [ "species_10444216", "catalyst" ] ], "additional_components": [ "species_29432", "species_29472", "CHEBI:58045", "species_379717", "species_351990", "species_111707", "species_200736", "species_29642", "species_351964", "species_379705", "species_6784215", "species_29702", "species_29472", "species_379717", "species_351990", "species_200736", "species_351964", "species_379705", "species_6784215", "CHEBI:58045", "species_29702", "species_29432", "species_29642", "species_111707", "Q8IQQ7", "FBgn0027660", "B7Z122", "FBgn0029663" ] }, "reaction_10450010": { "compartment": "compartment_876", "id": "reaction_10450010", "reactome": "R-DME-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10450007", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "species_114523", "species_390899", "species_351597", "species_351597", "CHEBI:28918", "species_390899", "species_380873", "species_114523", "Q8IH57", "FBgn0260964", "Q9VCJ5", "FBgn0043005" ] }, "reaction_10444839": { "compartment": "compartment_876", "id": "reaction_10444839", "reactome": "R-DME-374896", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10449926": { "compartment": "compartment_876", "id": "reaction_10449926", "reactome": "R-DME-443997", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935", "species_74113" ], "products": [ "species_209789", "species_83910" ], "modifiers": [ [ "species_10449923", "catalyst" ] ], "additional_components": [ "FBgn0034136" ] }, "reaction_10444198": { "compartment": "compartment_876", "id": "reaction_10444198", "reactome": "R-DME-351963", "name": "SLC6A18 transports Gly from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266029" ], "products": [ "species_29424" ], "modifiers": [ [ "species_10444195", "catalyst" ] ], "additional_components": [ "FBgn0029663" ] }, "reaction_10445109": { "compartment": "compartment_876", "id": "reaction_10445109", "reactome": "R-DME-375487", "name": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_375468", "species_74113" ], "products": [ "species_83910", "species_375459", "species_352022" ], "modifiers": [ [ "species_10445106", "catalyst" ] ], "additional_components": [ "species_29432", "species_29500", "CHEBI:58045", "species_29612", "species_200736", "species_29424", "species_29468", "species_73590", "species_29444", "species_111707", "species_351964", "species_379705", "species_29702", "species_200736", "species_29702", "species_29612", "species_29444", "species_29424", "species_351964", "species_379705", "CHEBI:58045", "species_73590", "species_29432", "species_111707", "species_29468", "species_29500", "A1ZBC7", "FBgn0034381", "Q9VJR4", "FBgn0028886", "Q9VLY5", "FBgn0031935", "Q9W1J0", "FBgn0034911", "A1Z8V9", "FBgn0033708", "Q7KTJ8", "FBgn0053296", "Q9VLY4", "FBgn0031936", "Q9VSV2", "FBgn0035969", "Q7K330", "FBgn0033443", "Q9VLY3", "FBgn0031937", "Q9VLY6", "FBgn0267326", "Q9W4C5", "FBgn0029762" ] }, "reaction_10445044": { "compartment": "compartment_876", "id": "reaction_10445044", "reactome": "R-DME-375473", "name": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375458", "species_74113" ], "products": [ "species_375481", "species_83910" ], "modifiers": [ [ "species_10445041", "catalyst" ] ], "additional_components": [ "species_29432", "species_29500", "species_29472", "CHEBI:58045", "species_111707", "species_200736", "species_29424", "species_351964", "species_379705", "species_29506", "species_29502", "species_29702", "species_29424", "species_29472", "species_29506", "species_200736", "species_351964", "species_379705", "CHEBI:58045", "species_29702", "species_29432", "species_111707", "species_29500", "species_29502", "Q8IQQ7", "FBgn0027660", "B7Z122", "FBgn0029663" ] }, "reaction_10444210": { "compartment": "compartment_876", "id": "reaction_10444210", "reactome": "R-DME-352052", "name": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033", "species_74113" ], "products": [ "species_83910", "species_113538" ], "modifiers": [ [ "species_10444207", "catalyst" ] ], "additional_components": [ "Q8IQQ7", "FBgn0027660", "B7Z122", "FBgn0029663" ] }, "reaction_10495345": { "compartment": "compartment_70101", "id": "reaction_10495345", "reactome": "R-DME-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10495342", "catalyst" ] ], "additional_components": [ "M9PEG6", "FBgn0035432", "Q9VPE3", "FBgn0037000" ] }, "reaction_10449676": { "compartment": "compartment_876", "id": "reaction_10449676", "reactome": "R-DME-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10449673", "catalyst" ] ], "additional_components": [ "FBgn0011672" ] }, "reaction_10449684": { "compartment": "compartment_876", "id": "reaction_10449684", "reactome": "R-DME-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10449681", "catalyst" ] ], "additional_components": [ "FBgn0037000" ] }, "reaction_10449699": { "compartment": "compartment_20699", "id": "reaction_10449699", "reactome": "R-DME-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10449696", "catalyst" ] ], "additional_components": [ "Q9VKA3", "FBgn0051860", "Q9V471", "FBgn0028516" ] }, "reaction_10449823": { "compartment": "compartment_876", "id": "reaction_10449823", "reactome": "R-DME-442387", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449820", "catalyst" ] ], "additional_components": [ "Q9VSL7", "FBgn0024236", "A4IJ72", "FBgn0036461" ] }, "reaction_10449831": { "compartment": "compartment_12045", "id": "reaction_10449831", "reactome": "R-DME-442393", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_442320" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449828", "catalyst" ] ], "additional_components": [ "FBgn0002022" ] }, "reaction_10449862": { "compartment": "compartment_876", "id": "reaction_10449862", "reactome": "R-DME-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449859", "catalyst" ] ], "additional_components": [ "Q9VFA2", "FBgn0038312", "Q9VEX1", "FBgn0038412", "Q7JZR2", "FBgn0033096", "A1Z6P0", "FBgn0033097", "Q9VSL7", "FBgn0024236" ] }, "reaction_10449812": { "compartment": "compartment_876", "id": "reaction_10449812", "reactome": "R-DME-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449809", "catalyst" ] ], "additional_components": [ "Q9VSL7", "FBgn0024236", "A4IJ72", "FBgn0036461" ] }, "reaction_10449712": { "compartment": "compartment_876", "id": "reaction_10449712", "reactome": "R-DME-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10449709", "catalyst" ] ], "additional_components": [ "FBgn0062413" ] }, "reaction_10449872": { "compartment": "compartment_876", "id": "reaction_10449872", "reactome": "R-DME-442661", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10449867", "catalyst" ] ], "additional_components": [ "FBgn0053181" ] }, "reaction_10450071": { "compartment": "compartment_984", "id": "reaction_10450071", "reactome": "R-DME-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10450068", "catalyst" ] ], "additional_components": [ "Q9VAP3", "FBgn0039637", "Q9VZE7", "FBgn0035523" ] }, "reaction_10449579": { "compartment": "compartment_876", "id": "reaction_10449579", "reactome": "R-DME-433104", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433138", "species_74113" ], "products": [ "species_76190", "species_83910" ], "modifiers": [ [ "species_10449576", "catalyst" ] ], "additional_components": [ "FBgn0036816" ] }, "reaction_10449561": { "compartment": "compartment_876", "id": "reaction_10449561", "reactome": "R-DME-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10449558", "catalyst" ] ], "additional_components": [ "Q9VDQ0", "FBgn0260466", "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816" ] }, "reaction_10449592": { "compartment": "compartment_876", "id": "reaction_10449592", "reactome": "R-DME-433114", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10449589", "catalyst" ] ], "additional_components": [ "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816", "Q9VDQ0", "FBgn0260466" ] }, "reaction_10449574": { "compartment": "compartment_876", "id": "reaction_10449574", "reactome": "R-DME-433101", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433123", "species_74113" ], "products": [ "species_29434", "species_83910" ], "modifiers": [ [ "species_10449571", "catalyst" ] ], "additional_components": [ "Q9VDQ0", "FBgn0260466", "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816" ] }, "reaction_10449605": { "compartment": "compartment_876", "id": "reaction_10449605", "reactome": "R-DME-433131", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433111", "species_74113" ], "products": [ "species_83910", "species_433124" ], "modifiers": [ [ "species_10449602", "catalyst" ] ], "additional_components": [ "species_29654", "species_29434", "species_29434", "species_29654", "Q9VDQ0", "FBgn0260466", "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816" ] }, "reaction_10453615": { "compartment": "compartment_876", "id": "reaction_10453615", "reactome": "R-DME-561054", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549266" ], "products": [ "species_549237" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:6801", "CHEBI:16797", "CHEBI:16737", "species_264638", "CHEBI:65133", "CHEBI:641", "species_114523", "species_351164", "species_390899", "CHEBI:31941", "species_351597", "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_351597", "CHEBI:65133", "species_351164", "species_390899", "species_264638", "CHEBI:16797", "species_114523", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10453453": { "compartment": "compartment_876", "id": "reaction_10453453", "reactome": "R-DME-549297", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10453450", "catalyst" ] ], "additional_components": [ "Q9VD40", "FBgn0038938", "Q9VCA0", "FBgn0039178", "Q961R9", "FBgn0038407", "A2RVG5", "FBgn0063649", "Q9VNX2", "FBgn0037140", "Q9VNW8", "FBgn0037144", "Q9VEY1", "FBgn0038404" ] }, "reaction_10453430": { "compartment": "compartment_876", "id": "reaction_10453430", "reactome": "R-DME-549279", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549237" ], "products": [ "species_549266" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_351597", "CHEBI:65133", "species_351164", "species_390899", "species_264638", "CHEBI:16797", "species_114523", "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:6801", "CHEBI:16797", "CHEBI:16737", "species_264638", "CHEBI:65133", "CHEBI:641", "species_114523", "species_351164", "species_390899", "CHEBI:31941", "species_351597", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10453654": { "compartment": "compartment_876", "id": "reaction_10453654", "reactome": "R-DME-561072", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549255" ], "products": [ "species_549326" ], "modifiers": [ [ "species_10453455", "catalyst" ] ], "additional_components": [ "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "FBgn0034479" ] }, "reaction_10453365": { "compartment": "compartment_876", "id": "reaction_10453365", "reactome": "R-DME-549129", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549264" ], "products": [ "species_549250" ], "modifiers": [ [ "species_10453362", "catalyst" ] ], "additional_components": [ "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_141324", "CHEBI:15854", "species_351597", "CHEBI:65133", "species_390899", "species_141342", "species_264638", "CHEBI:16797", "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "CHEBI:16797", "species_264638", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_141342", "species_351597", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "D2NUL5", "FBgn0264907", "Q9VDS2", "FBgn0038750" ] }, "reaction_10453460": { "compartment": "compartment_876", "id": "reaction_10453460", "reactome": "R-DME-549322", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549250" ], "products": [ "species_549264" ], "modifiers": [ [ "species_10453362", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "CHEBI:16797", "species_264638", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_141342", "species_351597", "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_141324", "CHEBI:15854", "species_351597", "CHEBI:65133", "species_390899", "species_141342", "species_264638", "CHEBI:16797", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "D2NUL5", "FBgn0264907", "Q9VDS2", "FBgn0038750" ] }, "reaction_10453458": { "compartment": "compartment_876", "id": "reaction_10453458", "reactome": "R-DME-549304", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549326" ], "products": [ "species_549255" ], "modifiers": [ [ "species_10453455", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "FBgn0034479" ] }, "reaction_10453426": { "compartment": "compartment_876", "id": "reaction_10453426", "reactome": "R-DME-549241", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549261", "species_74113" ], "products": [ "species_83910", "species_549260" ], "modifiers": [ [ "species_10453401", "catalyst" ], [ "species_10453424", "inhibitor" ] ], "additional_components": [ "Q9VCA0", "FBgn0039178", "Q961R9", "FBgn0038407", "A2RVG5", "FBgn0063649", "Q9VNX2", "FBgn0037140", "Q9VNW8", "FBgn0037144", "Q9VEY1", "FBgn0038404", "Q9VD40", "FBgn0038938", "M9PI08", "FBgn0083981", "Q9W349", "FBgn0002576", "Q9VRA9", "FBgn0259162", "P22814", "FBgn0003300" ] }, "reaction_10453613": { "compartment": "compartment_876", "id": "reaction_10453613", "reactome": "R-DME-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561049" ], "products": [ "species_561078", "species_561075" ], "modifiers": [ [ "species_10453610", "catalyst" ] ], "additional_components": [ "CHEBI:104011", "species_561052", "species_561052", "CHEBI:104011", "Q9VDV8", "FBgn0038717", "Q9VRQ8", "FBgn0035645", "Q9VDV7", "FBgn0038718", "Q9VFG2", "FBgn0038260", "Q9VDV6", "FBgn0038719", "Q9VFG1", "FBgn0038261", "Q9VDV5", "FBgn0038720", "Q9VFG0", "FBgn0038262", "Q9VCA2", "FBgn0019952", "Q9VDW0", "FBgn0038715", "Q9VRT4", "FBgn0259164", "Q95R48", "FBgn0086365", "Q9VDV9", "FBgn0038716", "Q9VRR0", "FBgn0035647", "Q86NP5", "FBgn0053233" ] }, "reaction_10453689": { "compartment": "compartment_876", "id": "reaction_10453689", "reactome": "R-DME-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10453686", "catalyst" ] ], "additional_components": [ "Q9VDV5", "FBgn0038720", "Q9VCA2", "FBgn0019952", "Q95R48", "FBgn0086365", "Q86NP5", "FBgn0053233", "Q9VRT4", "FBgn0259164", "Q9VRR0", "FBgn0035647", "Q9VRQ8", "FBgn0035645", "Q9VFG2", "FBgn0038260", "Q9VFG1", "FBgn0038261", "Q9VFG0", "FBgn0038262", "Q9VDW0", "FBgn0038715", "Q9VDV9", "FBgn0038716", "Q9VDV8", "FBgn0038717", "Q9VDV7", "FBgn0038718", "Q9VDV6", "FBgn0038719" ] }, "reaction_10453652": { "compartment": "compartment_876", "id": "reaction_10453652", "reactome": "R-DME-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561071" ], "products": [ "species_561062", "species_561075" ], "modifiers": [ [ "species_10453649", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176501", "species_176496", "Q9VDV9", "FBgn0038716", "Q9VDV8", "FBgn0038717", "Q9VDV7", "FBgn0038718", "Q9VDV6", "FBgn0038719", "Q9VDV5", "FBgn0038720", "Q9VCA2", "FBgn0019952", "Q95R48", "FBgn0086365", "Q86NP5", "FBgn0053233", "Q9VRT4", "FBgn0259164", "Q9VRR0", "FBgn0035647", "Q9VRQ8", "FBgn0035645", "Q9VFG2", "FBgn0038260", "Q9VFG1", "FBgn0038261", "Q9VFG0", "FBgn0038262", "Q9VDW0", "FBgn0038715" ] }, "reaction_10449536": { "compartment": "compartment_876", "id": "reaction_10449536", "reactome": "R-DME-433089", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433120", "species_74113" ], "products": [ "species_83910", "species_176483" ], "modifiers": [ [ "species_10449533", "catalyst" ] ], "additional_components": [ "Q9VXV4", "FBgn0030638", "Q9VXF5", "FBgn0030756" ] }, "reaction_10450045": { "compartment": "compartment_876", "id": "reaction_10450045", "reactome": "R-DME-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10450042", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450557": { "compartment": "compartment_876", "id": "reaction_10450557", "reactome": "R-DME-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10450047", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450555": { "compartment": "compartment_876", "id": "reaction_10450555", "reactome": "R-DME-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10450037", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450040": { "compartment": "compartment_876", "id": "reaction_10450040", "reactome": "R-DME-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10450037", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450050": { "compartment": "compartment_876", "id": "reaction_10450050", "reactome": "R-DME-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10450047", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10436318": { "compartment": "compartment_70616", "id": "reaction_10436318", "reactome": "R-DME-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113581", "species_113592" ], "modifiers": [ [ "species_10436315", "catalyst" ] ], "additional_components": [ "Q26365", "FBgn0003360", "O62526", "FBgn0025111" ] }, "reaction_10433387": { "compartment": "compartment_70101", "id": "reaction_10433387", "reactome": "R-DME-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10433362", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "FBgn0031250" ] }, "reaction_10453898": { "compartment": "compartment_70101", "id": "reaction_10453898", "reactome": "R-DME-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10453895", "catalyst" ] ], "additional_components": [ "species_83908", "species_83927", "CHEBI:16704", "CHEBI:16750", "CHEBI:17562", "CHEBI:17748", "species_83951", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_83951", "FBgn0031250" ] }, "reaction_10433401": { "compartment": "compartment_70101", "id": "reaction_10433401", "reactome": "R-DME-109539", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179740", "species_74113" ], "products": [ "species_179741", "species_83910" ], "modifiers": [ [ "species_10433398", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83908", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "Q7K4A1", "FBgn0025709", "A1Z7N3", "FBgn0033371" ] }, "reaction_10433385": { "compartment": "compartment_70101", "id": "reaction_10433385", "reactome": "R-DME-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10433362", "catalyst" ] ], "additional_components": [ "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "FBgn0031250" ] }, "reaction_10433367": { "compartment": "compartment_70101", "id": "reaction_10433367", "reactome": "R-DME-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10433360", "catalyst" ] ], "additional_components": [ "species_83908", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_29692", "species_29554", "CHEBI:17562", "species_83951", "species_113599", "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "CHEBI:17748", "species_113599", "species_83908", "species_29692", "species_29554", "species_83951", "CHEBI:17562", "CHEBI:16040", "FBgn0031250" ] }, "reaction_10433382": { "compartment": "compartment_70101", "id": "reaction_10433382", "reactome": "R-DME-109530", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179738", "species_74113" ], "products": [ "species_179739", "species_83910" ], "modifiers": [ [ "species_10433379", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "CHEBI:17256", "CHEBI:17256", "species_83908", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "A1Z7N3", "FBgn0033371", "Q7K4A1", "FBgn0025709" ] }, "reaction_10453910": { "compartment": "compartment_70101", "id": "reaction_10453910", "reactome": "R-DME-727768", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727737" ], "products": [ "species_727774" ], "modifiers": [ [ "species_10453890", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "species_83908", "species_114523", "species_351597", "species_351597", "species_83908", "species_114523", "species_380873", "CHEBI:28918", "FBgn0036319" ] }, "reaction_10433365": { "compartment": "compartment_70101", "id": "reaction_10433365", "reactome": "R-DME-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10433360", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "CHEBI:17748", "species_113599", "species_83908", "species_29692", "species_29554", "species_83951", "CHEBI:17562", "CHEBI:16040", "species_83908", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_29692", "species_29554", "CHEBI:17562", "species_83951", "species_113599", "FBgn0031250" ] }, "reaction_10453893": { "compartment": "compartment_70101", "id": "reaction_10453893", "reactome": "R-DME-727740", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727774" ], "products": [ "species_727737" ], "modifiers": [ [ "species_10453890", "catalyst" ] ], "additional_components": [ "species_351597", "species_83908", "species_114523", "species_380873", "CHEBI:28918", "species_380873", "CHEBI:28918", "species_83908", "species_114523", "species_351597", "FBgn0036319" ] }, "reaction_10433392": { "compartment": "compartment_70101", "id": "reaction_10433392", "reactome": "R-DME-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_179743", "species_83910" ], "modifiers": [ [ "species_10433389", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "FBgn0025709" ] }, "reaction_10454262": { "compartment": "compartment_876", "id": "reaction_10454262", "reactome": "R-DME-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10454259", "catalyst" ] ], "additional_components": [ "CHEBI:16196", "CHEBI:16196", "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10453918": { "compartment": "compartment_20699", "id": "reaction_10453918", "reactome": "R-DME-727807", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727810", "species_4085435" ], "products": [ "species_727815", "species_109395" ], "modifiers": [ [ "species_10453915", "catalyst" ] ], "additional_components": [ "FBgn0024994" ] }, "reaction_10453946": { "compartment": "compartment_20699", "id": "reaction_10453946", "reactome": "R-DME-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10453943", "catalyst" ] ], "additional_components": [ "FBgn0265351" ] }, "reaction_10453962": { "compartment": "compartment_20699", "id": "reaction_10453962", "reactome": "R-DME-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_113578", "species_744233" ], "modifiers": [ [ "species_10453959", "catalyst" ] ], "additional_components": [ "FBgn0042641" ] }, "reaction_10453957": { "compartment": "compartment_20699", "id": "reaction_10453957", "reactome": "R-DME-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10453951", "catalyst" ] ], "additional_components": [ "FBgn0029849" ] }, "reaction_10453923": { "compartment": "compartment_20699", "id": "reaction_10453923", "reactome": "R-DME-735702", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_735692" ], "products": [ "species_109402", "species_735691" ], "modifiers": [ [ "species_10453920", "catalyst" ] ], "additional_components": [ "species_735700", "species_735682", "species_735682", "species_735700", "FBgn0024994" ] }, "reaction_10453938": { "compartment": "compartment_20699", "id": "reaction_10453938", "reactome": "R-DME-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10453935", "catalyst" ] ], "additional_components": [ "Q9VVD9", "FBgn0036695", "Q9VEI3", "FBgn0038524" ] }, "reaction_10453954": { "compartment": "compartment_20699", "id": "reaction_10453954", "reactome": "R-DME-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10453951", "catalyst" ] ], "additional_components": [ "FBgn0029849" ] }, "reaction_10453906": { "compartment": "compartment_20699", "id": "reaction_10453906", "reactome": "R-DME-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10453903", "catalyst" ] ], "additional_components": [ "FBgn0036662" ] }, "reaction_10454239": { "compartment": "compartment_876", "id": "reaction_10454239", "reactome": "R-DME-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10454236", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q9VLB3", "FBgn0032123", "C8VV48", "FBgn0001296", "Q9W270", "FBgn0034715", "Q9VK82", "FBgn0032435", "Q9W269", "FBgn0034716", "Q8SY02", "FBgn0051634", "Q9VVH9", "FBgn0036732", "Q9W271", "FBgn0050277", "Q9VK84", "FBgn0032433" ] }, "reaction_10454189": { "compartment": "compartment_876", "id": "reaction_10454189", "reactome": "R-DME-879562", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879553" ], "products": [ "species_879654" ], "modifiers": [ [ "species_10454186", "catalyst" ] ], "additional_components": [ "species_176496", "CHEBI:63836", "species_176501", "CHEBI:63836", "species_176501", "species_176496", "FBgn0032123" ] }, "reaction_10454267": { "compartment": "compartment_876", "id": "reaction_10454267", "reactome": "R-DME-879594", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879521" ], "products": [ "species_879517" ], "modifiers": [ [ "species_10454264", "catalyst" ] ], "additional_components": [ "FBgn0051634" ] }, "reaction_10497799": { "compartment": "compartment_876", "id": "reaction_10497799", "reactome": "R-DME-9631987", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10454191", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "FBgn0032123" ] }, "reaction_10454184": { "compartment": "compartment_876", "id": "reaction_10454184", "reactome": "R-DME-879528", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879566" ], "products": [ "species_879614" ], "modifiers": [ [ "species_10454181", "catalyst" ] ], "additional_components": [ "species_879535", "CHEBI:15544", "species_416911", "species_265287", "species_416911", "CHEBI:15544", "species_879535", "species_265287", "FBgn0032123" ] }, "reaction_10448447": { "compartment": "compartment_876", "id": "reaction_10448447", "reactome": "R-DME-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428027", "species_29804", "species_74113" ], "products": [ "species_74126", "species_427997", "species_70106", "species_83910" ], "modifiers": [ [ "species_10442846", "catalyst" ] ], "additional_components": [ "species_113553", "species_6810061", "species_210382", "species_113553", "species_6810061", "species_210382", "FBgn0026438" ] }, "reaction_10448637": { "compartment": "compartment_201753", "id": "reaction_10448637", "reactome": "R-DME-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428592", "species_428548" ], "products": [ "species_428632", "species_70106" ], "modifiers": [ [ "species_10448634", "catalyst" ] ], "additional_components": [ "species_29424", "species_352011", "species_352011", "species_29424", "FBgn0033911" ] }, "reaction_10474318": { "compartment": "compartment_70101", "id": "reaction_10474318", "reactome": "R-DME-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10474315", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10448410": { "compartment": "compartment_876", "id": "reaction_10448410", "reactome": "R-DME-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10448405", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10448393": { "compartment": "compartment_876", "id": "reaction_10448393", "reactome": "R-DME-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10448390", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10448388": { "compartment": "compartment_876", "id": "reaction_10448388", "reactome": "R-DME-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_427648" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10448383", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10491197": { "compartment": "compartment_70101", "id": "reaction_10491197", "reactome": "R-DME-8875871", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648" ], "products": [ "species_174375" ], "modifiers": [ [ "species_10491194", "catalyst" ] ], "additional_components": [ "FBgn0036240" ] }, "reaction_10491278": { "compartment": "compartment_70101", "id": "reaction_10491278", "reactome": "R-DME-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876310", "species_74113" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10491275", "catalyst" ] ], "additional_components": [ "species_113557", "species_373863", "species_8869604", "species_113557", "species_373863", "species_197230", "P83740", "FBgn0052669", "Q8SWV5", "FBgn0034494" ] }, "reaction_10489060": { "compartment": "compartment_70101", "id": "reaction_10489060", "reactome": "R-DME-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_2162265", "species_71285" ], "modifiers": [ [ "species_10489057", "catalyst" ] ], "additional_components": [ "FBgn0039357" ] }, "reaction_10448403": { "compartment": "compartment_876", "id": "reaction_10448403", "reactome": "R-DME-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10448398", "catalyst" ] ], "additional_components": [ "FBgn0260795" ] }, "reaction_10448445": { "compartment": "compartment_876", "id": "reaction_10448445", "reactome": "R-DME-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_428026", "species_70106" ], "modifiers": [ [ "species_10448442", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:47923", "CHEBI:90799", "FBgn0028491" ] }, "reaction_10471671": { "compartment": "compartment_70101", "id": "reaction_10471671", "reactome": "R-DME-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_5673778" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10471668", "catalyst" ] ], "additional_components": [ "FBgn0039045" ] }, "reaction_10448940": { "compartment": "compartment_876", "id": "reaction_10448940", "reactome": "R-DME-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10448934", "catalyst" ] ], "additional_components": [ "FBgn0034494" ] }, "reaction_10448937": { "compartment": "compartment_876", "id": "reaction_10448937", "reactome": "R-DME-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429739", "species_74113" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10448934", "catalyst" ] ], "additional_components": [ "species_113557", "species_373863", "species_8869604", "CHEBI:30772", "species_29416", "CHEBI:30768", "CHEBI:30772", "species_113557", "species_29416", "species_373863", "CHEBI:30768", "species_197230", "FBgn0034494" ] }, "reaction_10448456": { "compartment": "compartment_201753", "id": "reaction_10448456", "reactome": "R-DME-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10448449", "catalyst" ] ], "additional_components": [ "FBgn0031424" ] }, "reaction_10448871": { "compartment": "compartment_876", "id": "reaction_10448871", "reactome": "R-DME-429591", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10442820", "catalyst" ] ], "additional_components": [ "P83740", "FBgn0052669", "Q8SWV5", "FBgn0034494" ] }, "reaction_10448629": { "compartment": "compartment_17938", "id": "reaction_10448629", "reactome": "R-DME-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_428633", "species_70106" ], "modifiers": [ [ "species_10448626", "catalyst" ] ], "additional_components": [ "FBgn0030452" ] }, "reaction_10491181": { "compartment": "compartment_70101", "id": "reaction_10491181", "reactome": "R-DME-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_113529", "species_113552" ], "modifiers": [ [ "species_10491178", "catalyst" ] ], "additional_components": [ "Q9VGF7", "FBgn0260743", "Q8INJ3", "FBgn0037970" ] }, "reaction_10460673": { "compartment": "compartment_70616", "id": "reaction_10460673", "reactome": "R-DME-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_1614584" ], "products": [ "species_113544", "species_174375" ], "modifiers": [ [ "species_10444381", "catalyst" ] ], "additional_components": [ "FBgn0027610" ] }, "reaction_10444384": { "compartment": "compartment_70101", "id": "reaction_10444384", "reactome": "R-DME-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10444381", "catalyst" ] ], "additional_components": [ "FBgn0027610" ] }, "reaction_10445035": { "compartment": "compartment_876", "id": "reaction_10445035", "reactome": "R-DME-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10445032", "catalyst" ] ], "additional_components": [ "species_29432", "species_379717", "species_29424", "species_29424", "species_379717", "species_29432", "FBgn0032036" ] }, "reaction_10445030": { "compartment": "compartment_876", "id": "reaction_10445030", "reactome": "R-DME-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10445027", "catalyst" ] ], "additional_components": [ "species_379717", "species_29424", "species_29424", "species_379717", "M9PEU1", "FBgn0263776", "Q7K2W3", "FBgn0033760", "Q9VT04", "FBgn0036007", "Q9VX84", "FBgn0030816", "Q4V5R4", "FBgn0033572", "Q9VLM3", "FBgn0032036", "Q9VTD7", "FBgn0036116", "M9PHT8", "FBgn0030817", "Q8IQF3", "FBgn0052081", "Q9VTD5", "FBgn0052079", "Q9W056", "FBgn0035300" ] }, "reaction_10448095": { "compartment": "compartment_876", "id": "reaction_10448095", "reactome": "R-DME-425482", "name": "SLC4A1,2,3 exchanges HCO3- for Cl-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10448088", "catalyst" ] ], "additional_components": [ "FBgn0036043" ] }, "reaction_10448107": { "compartment": "compartment_876", "id": "reaction_10448107", "reactome": "R-DME-425483", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10448100", "catalyst" ] ], "additional_components": [ "FBgn0259111" ] }, "reaction_10491757": { "compartment": "compartment_876", "id": "reaction_10491757", "reactome": "R-DME-8878664", "name": "SLC4A4 cotransports Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10491752", "catalyst" ], [ "species_10491755", "catalyst" ] ], "additional_components": [ "FBgn0259111", "FBgn0035371" ] }, "reaction_10448114": { "compartment": "compartment_876", "id": "reaction_10448114", "reactome": "R-DME-425577", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_425425", "species_352022", "species_74113" ], "products": [ "species_351626", "species_188972", "species_111627", "species_83910" ], "modifiers": [ [ "species_10448109", "catalyst" ] ], "additional_components": [ "FBgn0259111" ] }, "reaction_10474206": { "compartment": "compartment_263163", "id": "reaction_10474206", "reactome": "R-DME-5626316", "name": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5626313", "species_83910", "species_167012" ], "products": [ "species_29804", "species_74016", "species_425958" ], "modifiers": [ [ "species_10474203", "catalyst" ] ], "additional_components": [ "Q9VN12", "FBgn0037238", "Q7PLW4", "FBgn0039941", "Q5LJX8", "FBgn0265767", "A8Y5A2", "FBgn0040031" ] }, "reaction_10448158": { "compartment": "compartment_876", "id": "reaction_10448158", "reactome": "R-DME-425822", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425815", "species_74016" ], "products": [ "species_425810", "species_74112" ], "modifiers": [ [ "species_10448155", "catalyst" ] ], "additional_components": [ "FBgn0033324" ] }, "reaction_10448150": { "compartment": "compartment_876", "id": "reaction_10448150", "reactome": "R-DME-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_74126", "species_83910", "species_74112" ], "modifiers": [ [ "species_10448147", "catalyst" ] ], "additional_components": [ "Q9VN12", "FBgn0037238", "Q9U6A0", "FBgn0028704", "Q7PLW4", "FBgn0039941", "Q5LJX8", "FBgn0265767", "A8Y5A2", "FBgn0040031" ] }, "reaction_10444254": { "compartment": "compartment_876", "id": "reaction_10444254", "reactome": "R-DME-352379", "name": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352036", "species_29472", "species_74113" ], "products": [ "species_29432", "species_83910", "species_212615", "species_74113" ], "modifiers": [ [ "species_10444251", "catalyst" ] ], "additional_components": [ "FBgn0026438" ] }, "reaction_10445150": { "compartment": "compartment_876", "id": "reaction_10445150", "reactome": "R-DME-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445126", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q9VNP7", "FBgn0037203", "Q2PDY3", "FBgn0036493", "Q9VVM0", "FBgn0036764" ] }, "reaction_10445148": { "compartment": "compartment_876", "id": "reaction_10445148", "reactome": "R-DME-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445145", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q9VVM0", "FBgn0036764", "Q9VNP7", "FBgn0037203", "Q2PDY3", "FBgn0036493" ] }, "reaction_10495333": { "compartment": "compartment_70101", "id": "reaction_10495333", "reactome": "R-DME-8959781", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959777" ], "products": [ "species_8959775" ], "modifiers": [ [ "species_10495330", "catalyst" ] ], "additional_components": [ "CHEBI:28229", "species_113585", "species_29468", "species_29612", "species_29444", "CHEBI:27747", "species_113585", "species_29444", "species_29468", "species_29612", "CHEBI:28229", "CHEBI:27747", "FBgn0032219" ] }, "reaction_10444249": { "compartment": "compartment_876", "id": "reaction_10444249", "reactome": "R-DME-352371", "name": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352355", "species_352000", "species_74113" ], "products": [ "species_83910", "species_351990", "species_352359", "species_74113" ], "modifiers": [ [ "species_10444240", "catalyst" ] ], "additional_components": [ "species_200736", "species_351990", "species_29432", "species_111707", "species_29432", "species_351990", "species_111707", "species_200736", "FBgn0026438" ] }, "reaction_10445650": { "compartment": "compartment_876", "id": "reaction_10445650", "reactome": "R-DME-379432", "name": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29588", "species_379430" ], "products": [ "species_351964", "species_379440" ], "modifiers": [ [ "species_10445647", "catalyst" ] ], "additional_components": [ "species_379444", "species_29444", "species_29468", "species_379444", "species_29468", "species_29444", "Q8IR48", "FBgn0030574", "A1Z7E8", "FBgn0033294", "A1Z7F3", "FBgn0033297", "P07192", "FBgn0002571", "A0A4P1SA55", "FBgn0032382", "A1Z7F2", "FBgn0033296", "P07191", "FBgn0002569", "Q9VKE6", "FBgn0032381", "A1Z7F1", "FBgn0050360", "P07190", "FBgn0002570", "Q5U124", "FBgn0050359" ] }, "reaction_10445137": { "compartment": "compartment_876", "id": "reaction_10445137", "reactome": "R-DME-375770", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445134", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "FBgn0032911" ] }, "reaction_10490484": { "compartment": "compartment_876", "id": "reaction_10490484", "reactome": "R-DME-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10490478", "catalyst" ] ], "additional_components": [ "Q8IQF3", "FBgn0052081", "Q9VLM3", "FBgn0032036", "Q9VT04", "FBgn0036007", "Q9VTD5", "FBgn0052079", "M9PEU1", "FBgn0263776", "Q9VTD7", "FBgn0036116", "M9PHT8", "FBgn0030817", "Q9VX84", "FBgn0030816", "Q4V5R4", "FBgn0033572", "Q9W056", "FBgn0035300", "Q7K2W3", "FBgn0033760" ] }, "reaction_10445129": { "compartment": "compartment_876", "id": "reaction_10445129", "reactome": "R-DME-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445126", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q9VNP7", "FBgn0037203", "Q2PDY3", "FBgn0036493", "Q9VVM0", "FBgn0036764" ] }, "reaction_10444227": { "compartment": "compartment_876", "id": "reaction_10444227", "reactome": "R-DME-352158", "name": "SLC16A10-mediated uptake of aromatic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352161" ], "products": [ "species_352139" ], "modifiers": [ [ "species_10444224", "catalyst" ] ], "additional_components": [ "species_29500", "species_29506", "species_29502", "species_29506", "species_29500", "species_29502", "FBgn0001296" ] }, "reaction_10431078": { "compartment": "compartment_7660", "id": "reaction_10431078", "reactome": "R-DME-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431074", "species_10431069" ], "products": [ "species_10431076" ], "modifiers": [], "additional_components": [ "FBgn0032988", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9V9M6", "FBgn0032988" ] }, "reaction_10431182": { "compartment": "compartment_7660", "id": "reaction_10431182", "reactome": "R-DME-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431176" ], "products": [ "species_10431074", "species_10431180" ], "modifiers": [], "additional_components": [ "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9V9M6", "FBgn0032988", "Q9VH20", "FBgn0037792", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "FBgn0032988", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9VH20", "FBgn0037792", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10431966": { "compartment": "compartment_350", "id": "reaction_10431966", "reactome": "R-DME-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74985", "species_30595" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10431180", "catalyst" ] ], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9VH20", "FBgn0037792", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10457357": { "compartment": "compartment_70101", "id": "reaction_10457357", "reactome": "R-DME-984689", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457269" ], "products": [ "species_10457271" ], "modifiers": [], "additional_components": [ "FBgn0040232", "Q9VKI0", "FBgn0040232" ] }, "reaction_10457355": { "compartment": "compartment_70101", "id": "reaction_10457355", "reactome": "R-DME-984671", "name": "Chromokinesins form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450203" ], "products": [ "species_10457237" ], "modifiers": [], "additional_components": [ "FBgn0011606", "Q9XZ29", "FBgn0011606" ] }, "reaction_10457353": { "compartment": "compartment_70101", "id": "reaction_10457353", "reactome": "R-DME-984648", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457250", "species_10457255" ], "products": [ "species_10457257" ], "modifiers": [], "additional_components": [ "Q9VZF5", "FBgn0011692", "FBgn0086356", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692" ] }, "reaction_10457208": { "compartment": "compartment_70101", "id": "reaction_10457208", "reactome": "R-DME-983194", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457202", "species_10457191" ], "products": [ "species_10457206" ], "modifiers": [], "additional_components": [ "FBgn0001308", "FBgn0010235", "P46824", "FBgn0010235", "P17210", "FBgn0001308" ] }, "reaction_10457351": { "compartment": "compartment_70101", "id": "reaction_10457351", "reactome": "R-DME-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457242" ], "products": [ "species_10457244" ], "modifiers": [], "additional_components": [ "FBgn0004378", "P46863", "FBgn0004378" ] }, "reaction_10457365": { "compartment": "compartment_70101", "id": "reaction_10457365", "reactome": "R-DME-990489", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457363" ], "products": [ "species_10457311" ], "modifiers": [], "additional_components": [ "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268" ] }, "reaction_10457349": { "compartment": "compartment_70101", "id": "reaction_10457349", "reactome": "R-DME-983259", "name": "Kinesins move along microtubules consuming ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457347", "species_113592" ], "products": [ "species_10457347", "species_29370" ], "modifiers": [], "additional_components": [ "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379", "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379" ] }, "reaction_10457361": { "compartment": "compartment_70101", "id": "reaction_10457361", "reactome": "R-DME-984733", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457359" ], "products": [ "species_10457233" ], "modifiers": [], "additional_components": [ "Q9VRK9", "FBgn0004380", "Q9VRK9", "FBgn0004380" ] }, "reaction_10450651": { "compartment": "compartment_70101", "id": "reaction_10450651", "reactome": "R-DME-448702", "name": "Caspase-1 active tetramer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450627" ], "products": [ "species_10450649" ], "modifiers": [], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd" ] }, "reaction_10450629": { "compartment": "compartment_70101", "id": "reaction_10450629", "reactome": "R-DME-448673", "name": "Formation of caspase-1 p10/p20 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450625", "species_10450619" ], "products": [ "species_10450627" ], "modifiers": [], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd" ] }, "reaction_10442686": { "compartment": "compartment_70101", "id": "reaction_10442686", "reactome": "R-DME-209063", "name": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442681", "species_10426987" ], "products": [ "species_10442683" ], "modifiers": [ [ "species_10442677", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10451597": { "compartment": "compartment_70101", "id": "reaction_10451597", "reactome": "R-DME-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451588" ], "products": [ "species_10451594" ], "modifiers": [ [ "species_10451588", "catalyst" ] ], "additional_components": [ "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "O77237", "FBgn0025574", "O77237", "FBgn0025574", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "O77237", "FBgn0025574" ] }, "reaction_10442695": { "compartment": "compartment_70101", "id": "reaction_10442695", "reactome": "R-DME-209125", "name": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442677", "species_10442679" ], "products": [ "species_10442681" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10442693": { "compartment": "compartment_70101", "id": "reaction_10442693", "reactome": "R-DME-209087", "name": "IKBA is phosphorylated by Phospho IKKB kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437415" ], "products": [ "species_29370", "species_10437421" ], "modifiers": [ [ "species_10442690", "catalyst" ] ], "additional_components": [] }, "reaction_10450611": { "compartment": "compartment_70101", "id": "reaction_10450611", "reactome": "R-DME-446877", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450601" ], "products": [ "species_10450608" ], "modifiers": [ [ "species_10450601", "catalyst" ] ], "additional_components": [ "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "Q9W3I9", "FBgn0265464", "Q9W3I9", "FBgn0265464", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "Q9W3I9", "FBgn0265464" ] }, "reaction_10442673": { "compartment": "compartment_70101", "id": "reaction_10442673", "reactome": "R-DME-209061", "name": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442671" ], "products": [ "species_10437411", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10495861": { "compartment": "compartment_984", "id": "reaction_10495861", "reactome": "R-DME-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_29370", "species_10437429" ], "modifiers": [], "additional_components": [] }, "reaction_10496003": { "compartment": "compartment_70101", "id": "reaction_10496003", "reactome": "R-DME-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10445855" ], "products": [ "species_29370", "species_10495728" ], "modifiers": [], "additional_components": [] }, "reaction_10495919": { "compartment": "compartment_70101", "id": "reaction_10495919", "reactome": "R-DME-9008684", "name": "TBK1 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10455277" ], "products": [ "species_10495917", "species_29370" ], "modifiers": [], "additional_components": [ "FBgn0086657", "FBgn0086657" ] }, "reaction_10460539": { "compartment": "compartment_161320", "id": "reaction_10460539", "reactome": "R-DME-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605637", "species_1605601" ], "modifiers": [ [ "species_10460536", "catalyst" ] ], "additional_components": [ "Q7K127", "FBgn0034117", "Q9VL27", "FBgn0032192" ] }, "reaction_10460569": { "compartment": "compartment_876", "id": "reaction_10460569", "reactome": "R-DME-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10460566", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VZS6", "FBgn0035421" ] }, "reaction_10460472": { "compartment": "compartment_17938", "id": "reaction_10460472", "reactome": "R-DME-1605591", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605592" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10460469", "catalyst" ] ], "additional_components": [ "Q9Y125", "FBgn0000416", "Q8IMY3", "FBgn0051414" ] }, "reaction_10460822": { "compartment": "compartment_876", "id": "reaction_10460822", "reactome": "R-DME-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_113592" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10460819", "catalyst" ] ], "additional_components": [ "FBgn0037315" ] }, "reaction_10460591": { "compartment": "compartment_876", "id": "reaction_10460591", "reactome": "R-DME-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429807" ], "products": [ "species_1606609", "species_1861754" ], "modifiers": [ [ "species_10460588", "catalyst" ] ], "additional_components": [] }, "reaction_10460814": { "compartment": "compartment_20699", "id": "reaction_10460814", "reactome": "R-DME-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744227", "species_428270" ], "products": [ "species_1660674", "species_205687" ], "modifiers": [ [ "species_10460811", "catalyst" ] ], "additional_components": [ "FBgn0067102" ] }, "reaction_10461805": { "compartment": "compartment_70101", "id": "reaction_10461805", "reactome": "R-DME-1861789", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861764" ], "products": [ "species_194377", "species_70113" ], "modifiers": [ [ "species_10461802", "catalyst" ] ], "additional_components": [ "FBgn0036659" ] }, "reaction_10491828": { "compartment": "compartment_17963", "id": "reaction_10491828", "reactome": "R-DME-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_8879102" ], "products": [ "species_8879101", "species_205687" ], "modifiers": [ [ "species_10491825", "catalyst" ] ], "additional_components": [ "FBgn0000221" ] }, "reaction_10460522": { "compartment": "compartment_161320", "id": "reaction_10460522", "reactome": "R-DME-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605608" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10460519", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10471658": { "compartment": "compartment_70101", "id": "reaction_10471658", "reactome": "R-DME-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10471655", "catalyst" ] ], "additional_components": [ "FBgn0050392" ] }, "reaction_10461800": { "compartment": "compartment_876", "id": "reaction_10461800", "reactome": "R-DME-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861782" ], "products": [ "species_429807", "species_70113" ], "modifiers": [ [ "species_10461797", "catalyst" ] ], "additional_components": [ "FBgn0028916" ] }, "reaction_10460581": { "compartment": "compartment_161320", "id": "reaction_10460581", "reactome": "R-DME-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605637", "species_1605592" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_10460644": { "compartment": "compartment_17957", "id": "reaction_10460644", "reactome": "R-DME-1614362", "name": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194653", "species_10460622" ], "products": [ "species_10460641", "species_1663154", "species_194697" ], "modifiers": [ [ "species_10460596", "catalyst" ] ], "additional_components": [ "Q8SZ72", "FBgn0033763", "Q8IQS4", "FBgn0052191", "Q9VVM4", "FBgn0036768", "Q9VVM1", "FBgn0036765", "Q8SZ72", "FBgn0033763", "Q9VVM4", "FBgn0036768", "Q9VVM1", "FBgn0036765", "Q8IQS4", "FBgn0052191", "FBgn0035102" ] }, "reaction_10460547": { "compartment": "compartment_161320", "id": "reaction_10460547", "reactome": "R-DME-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10460544", "catalyst" ] ], "additional_components": [ "FBgn0034997" ] }, "reaction_10460579": { "compartment": "compartment_17957", "id": "reaction_10460579", "reactome": "R-DME-1606288", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_1606283" ], "products": [ "species_428256", "species_1606280" ], "modifiers": [ [ "species_10460576", "catalyst" ] ], "additional_components": [ "Q9VGH0", "FBgn0037958", "species_29926" ] }, "reaction_10471683": { "compartment": "compartment_876", "id": "reaction_10471683", "reactome": "R-DME-5340320", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340315" ], "products": [ "species_5340299" ], "modifiers": [ [ "species_10471680", "catalyst" ] ], "additional_components": [ "FBgn0030641" ] }, "reaction_10479745": { "compartment": "compartment_70101", "id": "reaction_10479745", "reactome": "R-DME-6785933", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452", "species_429807" ], "products": [ "species_6785915", "species_110096" ], "modifiers": [ [ "species_10479742", "catalyst" ] ], "additional_components": [ "FBgn0040257" ] }, "reaction_10460480": { "compartment": "compartment_161320", "id": "reaction_10460480", "reactome": "R-DME-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_209094": { "compartment": "compartment_70101", "id": "reaction_209094", "reactome": "R-DME-209094", "name": "Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex'", "reversible": "false", "notes": "The bound and phosphorylated Armadillo (ARM) is ubiquitated by the ubiquitin ligase assembled complex, whether this occurs when ARM is bound to the 'destruction complex' or after it has dissociated from it is unclear. The interaction between Slimb (SLMB) and ARM has weakened the latter's binding to the scaffolding molecules in the 'destruction complex'. ARM and the bound ubiquitin ligase assembled complex dissociate from Axin (AXN), APC (APC/APC2) and also from each other to leave free ubiquitinated and phosphorylated ARM which is now marked for degradation by the 26S proteasome.", "reactants": [ "species_206204", "species_207002" ], "products": [ "species_206991", "species_206602", "species_206788" ], "modifiers": [ [ "species_207002", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P18824", "arm", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209129": { "compartment": "compartment_70101", "id": "reaction_209129", "reactome": "R-DME-209129", "name": "Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex", "reversible": "false", "notes": "The free ubiquitinated and phosphorylated Armadillo (ARM) is now targeted by the 26S proteasome which binds and then degrades it. The cytoplasmic concentration of Armadillo is now reduced.", "reactants": [ "species_206991" ], "products": [ "species_206204" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "P18824", "arm", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_209102": { "compartment": "compartment_70101", "id": "reaction_209102", "reactome": "R-DME-209102", "name": "SLMB binds to phosphorylated ARM to form the 'destruction complex'", "reversible": "false", "notes": "The phosphorylated Armadillo (ARM) is now recognised and bound by the F-box protein Slimb (SLMB), in the E3 ubiquitin ligase assembled complex additionally containing the S-phase kinase-associated protein SKPA, the Cullin orthologue, LIN19, the Ring-box protein containg ROC1A, and the ubiquitin-conjugating enzyme orthologue EFF.", "reactants": [ "species_206788", "species_207028" ], "products": [ "species_207002" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_10459100": { "compartment": "compartment_7660", "id": "reaction_10459100", "reactome": "R-DME-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458007", "species_10459084" ], "products": [ "species_10459098" ], "modifiers": [], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q24472", "Rbf" ] }, "reaction_10458025": { "compartment": "compartment_7660", "id": "reaction_10458025", "reactome": "R-DME-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458009", "species_10457450" ], "products": [ "species_10458023" ], "modifiers": [], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q94517", "HDAC1", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10459096": { "compartment": "compartment_7660", "id": "reaction_10459096", "reactome": "R-DME-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458009", "species_10459084" ], "products": [ "species_10459094" ], "modifiers": [], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10458999": { "compartment": "compartment_7660", "id": "reaction_10458999", "reactome": "R-DME-1362261", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458995", "species_10457963" ], "products": [ "species_10458997" ], "modifiers": [], "additional_components": [ "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979" ] }, "reaction_10458021": { "compartment": "compartment_7660", "id": "reaction_10458021", "reactome": "R-DME-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457450", "species_10457963" ], "products": [ "species_10458019" ], "modifiers": [], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q94517", "HDAC1" ] }, "reaction_10459092": { "compartment": "compartment_7660", "id": "reaction_10459092", "reactome": "R-DME-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457947", "species_10459084" ], "products": [ "species_10459090" ], "modifiers": [], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9VF04", "FBgn0038390", "Q24472", "Rbf" ] }, "reaction_10459011": { "compartment": "compartment_7660", "id": "reaction_10459011", "reactome": "R-DME-1362270", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10459003" ], "products": [ "species_113582", "species_10458995" ], "modifiers": [ [ "species_10459008", "catalyst" ] ], "additional_components": [ "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979", "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979", "FBgn0259168" ] }, "reaction_10459088": { "compartment": "compartment_7660", "id": "reaction_10459088", "reactome": "R-DME-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457963", "species_10459084" ], "products": [ "species_10459086" ], "modifiers": [], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10439374": { "compartment": "compartment_13231", "id": "reaction_10439374", "reactome": "R-DME-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439372" ], "products": [ "species_10427755" ], "modifiers": [], "additional_components": [ "FBgn0010316", "FBgn0010316" ] }, "reaction_10439484": { "compartment": "compartment_7660", "id": "reaction_10439484", "reactome": "R-DME-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427716" ], "products": [ "species_113582", "species_10427482" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10440842": { "compartment": "compartment_70101", "id": "reaction_10440842", "reactome": "R-DME-198613", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439372" ], "products": [ "species_29370", "species_10440840" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0010316", "FBgn0010316" ] }, "reaction_10435622": { "compartment": "compartment_13231", "id": "reaction_10435622", "reactome": "R-DME-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427710" ], "products": [ "species_10427716" ], "modifiers": [], "additional_components": [ "P54733", "FBgn0010382", "P23573", "FBgn0004107", "P23573", "FBgn0004107" ] }, "reaction_10439404": { "compartment": "compartment_7660", "id": "reaction_10439404", "reactome": "R-DME-187575", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439395", "species_10427430" ], "products": [ "species_10439399" ], "modifiers": [ [ "species_10439395", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10439401": { "compartment": "compartment_7660", "id": "reaction_10439401", "reactome": "R-DME-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439399" ], "products": [ "species_10439393", "species_10427430", "species_10427484" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10439384": { "compartment": "compartment_7660", "id": "reaction_10439384", "reactome": "R-DME-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439376", "species_29358" ], "products": [ "species_113582", "species_10439381" ], "modifiers": [ [ "species_10439376", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316" ] }, "reaction_10439397": { "compartment": "compartment_7660", "id": "reaction_10439397", "reactome": "R-DME-187552", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439393", "species_10439381" ], "products": [ "species_10439395" ], "modifiers": [], "additional_components": [ "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10427729": { "compartment": "compartment_7660", "id": "reaction_10427729", "reactome": "R-DME-69195", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427716" ], "products": [ "species_113582", "species_10427721" ], "modifiers": [ [ "species_10427726", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "FBgn0011737" ] }, "reaction_10427712": { "compartment": "compartment_70101", "id": "reaction_10427712", "reactome": "R-DME-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427704", "species_10427706" ], "products": [ "species_10427710" ], "modifiers": [], "additional_components": [ "FBgn0004107", "FBgn0010382", "P54733", "FBgn0010382", "P23573", "FBgn0004107" ] }, "reaction_10427760": { "compartment": "compartment_7660", "id": "reaction_10427760", "reactome": "R-DME-69562", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427716", "species_10427755" ], "products": [ "species_10427757" ], "modifiers": [ [ "species_10427755", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "FBgn0010316", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "FBgn0010316" ] }, "reaction_10427744": { "compartment": "compartment_7660", "id": "reaction_10427744", "reactome": "R-DME-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10427721" ], "products": [ "species_113550", "species_10427716" ], "modifiers": [ [ "species_10427741", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P54733", "FBgn0010382", "P23573", "FBgn0004107", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10427470": { "compartment": "compartment_7660", "id": "reaction_10427470", "reactome": "R-DME-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68419", "species_10427294" ], "products": [ "species_10427296" ], "modifiers": [ [ "species_10427363", "catalyst" ] ], "additional_components": [ "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427372": { "compartment": "compartment_7660", "id": "reaction_10427372", "reactome": "R-DME-68918", "name": "CDK and DDK associate with the Mcm10:pre-replicative complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427348", "species_10427336", "species_10427357" ], "products": [ "species_10427359" ], "modifiers": [], "additional_components": [ "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "P23573", "FBgn0004107", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427468": { "compartment": "compartment_7660", "id": "reaction_10427468", "reactome": "R-DME-68954", "name": "Mcm2-7 is phosphorylated by DDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427244" ], "products": [ "species_113582", "species_10427465" ], "modifiers": [ [ "species_10427348", "catalyst" ] ], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "species_29372", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427370": { "compartment": "compartment_7660", "id": "reaction_10427370", "reactome": "R-DME-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427359", "species_10427327" ], "products": [ "species_10427361" ], "modifiers": [], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "FBgn0026143", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427368": { "compartment": "compartment_7660", "id": "reaction_10427368", "reactome": "R-DME-68916", "name": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427361", "species_10427322" ], "products": [ "species_10427363" ], "modifiers": [], "additional_components": [ "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427750": { "compartment": "compartment_7660", "id": "reaction_10427750", "reactome": "R-DME-69299", "name": "Cdt1 associates with geminin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427746", "species_10427208" ], "products": [ "species_10427748" ], "modifiers": [], "additional_components": [ "FBgn0033081", "FBgn0000996", "Q7JVY2", "FBgn0000996", "Q7JX41", "FBgn0033081" ] }, "reaction_10427365": { "compartment": "compartment_7660", "id": "reaction_10427365", "reactome": "R-DME-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427296", "species_10427272" ], "products": [ "species_10427298" ], "modifiers": [ [ "species_10427363", "catalyst" ] ], "additional_components": [ "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427378": { "compartment": "compartment_7660", "id": "reaction_10427378", "reactome": "R-DME-68940", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427374" ], "products": [ "species_10427208", "species_10427357" ], "modifiers": [], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "FBgn0000996", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929" ] }, "reaction_10427376": { "compartment": "compartment_7660", "id": "reaction_10427376", "reactome": "R-DME-68919", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427353", "species_10427246" ], "products": [ "species_10427374" ], "modifiers": [], "additional_components": [ "FBgn0032929", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929" ] }, "reaction_10493217": { "compartment": "compartment_70101", "id": "reaction_10493217", "reactome": "R-DME-8941895", "name": "Formation of CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487898", "species_10432397" ], "products": [ "species_10487900" ], "modifiers": [], "additional_components": [ "FBgn0010315", "FBgn0016131", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10493286": { "compartment": "compartment_13231", "id": "reaction_10493286", "reactome": "R-DME-8942803", "name": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493276" ], "products": [ "species_10493284" ], "modifiers": [], "additional_components": [ "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7JNL9", "FBgn0010316" ] }, "reaction_10493223": { "compartment": "compartment_70101", "id": "reaction_10493223", "reactome": "R-DME-8941915", "name": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487900", "species_10439372" ], "products": [ "species_10493221" ], "modifiers": [], "additional_components": [ "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "FBgn0010316", "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10459080": { "compartment": "compartment_7660", "id": "reaction_10459080", "reactome": "R-DME-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10457975" ], "products": [ "species_113550", "species_10457947" ], "modifiers": [ [ "species_10459075", "catalyst" ] ], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q9VF04", "FBgn0038390", "Q24472", "Rbf" ] }, "reaction_10493288": { "compartment": "compartment_7660", "id": "reaction_10493288", "reactome": "R-DME-8942836", "name": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10493284" ], "products": [ "species_113582", "species_10458002" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7JNL9", "FBgn0010316", "Q7JNL9", "FBgn0010316", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10459078": { "compartment": "compartment_7660", "id": "reaction_10459078", "reactome": "R-DME-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10458015" ], "products": [ "species_113550", "species_10458007" ], "modifiers": [ [ "species_10459075", "catalyst" ] ], "additional_components": [] }, "reaction_10493274": { "compartment": "compartment_70101", "id": "reaction_10493274", "reactome": "R-DME-8942607", "name": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10493221" ], "products": [ "species_29370", "species_10493251" ], "modifiers": [ [ "species_10493271", "catalyst" ] ], "additional_components": [ "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10458005": { "compartment": "compartment_7660", "id": "reaction_10458005", "reactome": "R-DME-1226094", "name": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10457963" ], "products": [ "species_113582", "species_10457975", "species_10457977" ], "modifiers": [ [ "species_10458002", "catalyst" ] ], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q7JNL9", "FBgn0010316", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10459109": { "compartment": "compartment_7660", "id": "reaction_10459109", "reactome": "R-DME-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10459102" ], "products": [ "species_10439393", "species_10459106" ], "modifiers": [ [ "species_10459102", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10458017": { "compartment": "compartment_7660", "id": "reaction_10458017", "reactome": "R-DME-1226095", "name": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10458009" ], "products": [ "species_113582", "species_10457977", "species_10458015" ], "modifiers": [ [ "species_10458002", "catalyst" ] ], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q7JNL9", "FBgn0010316", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10459104": { "compartment": "compartment_7660", "id": "reaction_10459104", "reactome": "R-DME-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439393", "species_10457975" ], "products": [ "species_10459102" ], "modifiers": [], "additional_components": [ "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10439450": { "compartment": "compartment_7660", "id": "reaction_10439450", "reactome": "R-DME-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426928", "species_10427405" ], "products": [ "species_10439448" ], "modifiers": [], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q27368", "phospho-E2f1" ] }, "reaction_10439464": { "compartment": "compartment_7660", "id": "reaction_10439464", "reactome": "R-DME-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10439448" ], "products": [ "species_113582", "species_10439461" ], "modifiers": [ [ "species_10439448", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "Q27368", "phospho-E2f1", "P23573", "FBgn0004107", "Q27368", "phospho-E2f1", "P23573", "FBgn0004107", "Q27368", "phospho-E2f1" ] }, "reaction_10437631": { "compartment": "compartment_13231", "id": "reaction_10437631", "reactome": "R-DME-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437595" ], "products": [ "species_10437575" ], "modifiers": [ [ "species_10437629", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "FBgn0020497" ] }, "reaction_10437726": { "compartment": "compartment_70101", "id": "reaction_10437726", "reactome": "R-DME-170161", "name": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10437719" ], "products": [ "species_29372", "species_10437723" ], "modifiers": [ [ "species_10437671", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437692": { "compartment": "compartment_13231", "id": "reaction_10437692", "reactome": "R-DME-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435511" ], "products": [ "species_10437690" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437659": { "compartment": "compartment_13231", "id": "reaction_10437659", "reactome": "R-DME-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437657" ], "products": [ "species_10437651" ], "modifiers": [], "additional_components": [ "P23572", "FBgn0004106", "P23572", "FBgn0004106" ] }, "reaction_10437624": { "compartment": "compartment_7660", "id": "reaction_10437624", "reactome": "R-DME-170070", "name": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437622" ], "products": [ "species_113582", "species_10437595" ], "modifiers": [ [ "species_10427726", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "FBgn0011737" ] }, "reaction_10437655": { "compartment": "compartment_7660", "id": "reaction_10437655", "reactome": "R-DME-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437651" ], "products": [ "species_113582", "species_10437653" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P23572", "FBgn0004106", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10437684": { "compartment": "compartment_13231", "id": "reaction_10437684", "reactome": "R-DME-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437583" ], "products": [ "species_10437601" ], "modifiers": [], "additional_components": [ "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10489387": { "compartment": "compartment_7660", "id": "reaction_10489387", "reactome": "R-DME-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10459075" ], "products": [ "species_77502", "species_10489379" ], "modifiers": [ [ "species_10489384", "catalyst" ] ], "additional_components": [ "FBgn0028507" ] }, "reaction_10437715": { "compartment": "compartment_13231", "id": "reaction_10437715", "reactome": "R-DME-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437713" ], "products": [ "species_10437696" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437618": { "compartment": "compartment_70101", "id": "reaction_10437618", "reactome": "R-DME-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437568", "species_10437609" ], "products": [ "species_10437611" ], "modifiers": [], "additional_components": [ "FBgn0000405", "FBgn0004106", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10437682": { "compartment": "compartment_70101", "id": "reaction_10437682", "reactome": "R-DME-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437675" ], "products": [ "species_29370", "species_10437583" ], "modifiers": [ [ "species_10437679", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P20439", "FBgn0000405", "P23572", "FBgn0004106" ] }, "reaction_10437649": { "compartment": "compartment_70101", "id": "reaction_10437649", "reactome": "R-DME-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437609", "species_10437645" ], "products": [ "species_10437647" ], "modifiers": [], "additional_components": [ "FBgn0004106", "P23572", "FBgn0004106" ] }, "reaction_10437616": { "compartment": "compartment_70101", "id": "reaction_10437616", "reactome": "R-DME-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437611" ], "products": [ "species_10437570", "species_29370" ], "modifiers": [ [ "species_10437613", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "FBgn0040298" ] }, "reaction_10489395": { "compartment": "compartment_7660", "id": "reaction_10489395", "reactome": "R-DME-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10489379" ], "products": [ "species_10459075", "species_8857797" ], "modifiers": [ [ "species_10489392", "catalyst" ] ], "additional_components": [ "FBgn0035951" ] }, "reaction_10437705": { "compartment": "compartment_7660", "id": "reaction_10437705", "reactome": "R-DME-170158", "name": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10437701" ], "products": [ "species_113550", "species_10437703" ], "modifiers": [ [ "species_10427741", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P23572", "FBgn0004106", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437673": { "compartment": "compartment_13231", "id": "reaction_10437673", "reactome": "R-DME-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437665" ], "products": [ "species_10437671" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437605": { "compartment": "compartment_13231", "id": "reaction_10437605", "reactome": "R-DME-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437585" ], "products": [ "species_10437603" ], "modifiers": [], "additional_components": [ "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10437635": { "compartment": "compartment_7660", "id": "reaction_10437635", "reactome": "R-DME-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437591" ], "products": [ "species_113582", "species_10437622" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10437699": { "compartment": "compartment_7660", "id": "reaction_10437699", "reactome": "R-DME-170153", "name": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10437595" ], "products": [ "species_113550", "species_10437694" ], "modifiers": [ [ "species_10437696", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10435532": { "compartment": "compartment_7660", "id": "reaction_10435532", "reactome": "R-DME-156699", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427726" ], "products": [ "species_113582", "species_10435530" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0011737", "FBgn0011737", "FBgn0003124" ] }, "reaction_10435516": { "compartment": "compartment_7660", "id": "reaction_10435516", "reactome": "R-DME-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10435503" ], "products": [ "species_29370", "species_10435511" ], "modifiers": [ [ "species_10435513", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0003124" ] }, "reaction_10435996": { "compartment": "compartment_7660", "id": "reaction_10435996", "reactome": "R-DME-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10435991" ], "products": [ "species_113582", "species_10435994" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0040298", "FBgn0040298", "FBgn0003124" ] }, "reaction_10488880": { "compartment": "compartment_70101", "id": "reaction_10488880", "reactome": "R-DME-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488823", "species_10426987" ], "products": [ "species_10488877" ], "modifiers": [ [ "species_10488823", "catalyst" ] ], "additional_components": [ "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147" ] }, "reaction_10488882": { "compartment": "compartment_70101", "id": "reaction_10488882", "reactome": "R-DME-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488877" ], "products": [ "species_10488821", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10488825": { "compartment": "compartment_70101", "id": "reaction_10488825", "reactome": "R-DME-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438226", "species_10488821" ], "products": [ "species_10488823" ], "modifiers": [], "additional_components": [ "FBgn0000147", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147" ] }, "reaction_10488890": { "compartment": "compartment_70101", "id": "reaction_10488890", "reactome": "R-DME-8854051", "name": "SCF-FBXL18 ubiquitinates FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456346", "species_10426987" ], "products": [ "species_10488885" ], "modifiers": [ [ "species_10488887", "catalyst" ] ], "additional_components": [ "FBgn0038385", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236" ] }, "reaction_10488892": { "compartment": "compartment_70101", "id": "reaction_10488892", "reactome": "R-DME-8854052", "name": "Formation of the SCF-FBXL7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442675", "species_10438327", "species_10438329", "species_10456346" ], "products": [ "species_10488821" ], "modifiers": [], "additional_components": [ "FBgn0038385", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10488894": { "compartment": "compartment_70101", "id": "reaction_10488894", "reactome": "R-DME-8854071", "name": "Proteasome-mediated degradation of PolyUb-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488885" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0038385", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10469628": { "compartment": "compartment_70101", "id": "reaction_10469628", "reactome": "R-DME-4086410", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469626" ], "products": [ "species_29370", "species_10467358" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "FBgn0259791", "FBgn0259791", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10467367": { "compartment": "compartment_70101", "id": "reaction_10467367", "reactome": "R-DME-3000327", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467360", "species_113592" ], "products": [ "species_10467364", "species_29370", "species_10435513" ], "modifiers": [ [ "species_10467360", "catalyst" ] ], "additional_components": [ "Q9VVR2", "FBgn0259791", "P52304", "FBgn0003124", "FBgn0259791", "FBgn0003124", "Q9VVR2", "FBgn0259791", "P52304", "FBgn0003124" ] }, "reaction_10467399": { "compartment": "compartment_7660", "id": "reaction_10467399", "reactome": "R-DME-3002811", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10435494" ], "products": [ "species_113550", "species_10467382" ], "modifiers": [ [ "species_10467396", "catalyst" ] ], "additional_components": [ "FBgn0003124", "FBgn0003124", "M9NEB2", "FBgn0005536", "P48462", "flw" ] }, "reaction_10467380": { "compartment": "compartment_70101", "id": "reaction_10467380", "reactome": "R-DME-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435513" ], "products": [ "species_10435494" ], "modifiers": [], "additional_components": [ "FBgn0003124", "FBgn0003124" ] }, "reaction_10427303": { "compartment": "compartment_7660", "id": "reaction_10427303", "reactome": "R-DME-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427298", "species_30595" ], "products": [ "species_10427300", "species_10427294" ], "modifiers": [ [ "species_10427298", "catalyst" ] ], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "species_110577", "species_113592", "species_29494", "species_29438", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644" ] }, "reaction_10427463": { "compartment": "compartment_7660", "id": "reaction_10427463", "reactome": "R-DME-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427300", "species_30187", "species_30185", "species_29892", "species_29604" ], "products": [ "species_10427460" ], "modifiers": [ [ "species_10427272", "catalyst" ] ], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113" ] }, "reaction_10427595": { "compartment": "compartment_7660", "id": "reaction_10427595", "reactome": "R-DME-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427244" ], "products": [ "species_10427217", "species_10427593", "species_10427242", "species_10427227" ], "modifiers": [], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "FBgn0284442", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9V461", "FBgn0025815", "FBgn0014861", "FBgn0017577" ] }, "reaction_10427452": { "compartment": "compartment_7660", "id": "reaction_10427452", "reactome": "R-DME-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10427382" ], "products": [ "species_10427433" ], "modifiers": [ [ "species_10427449", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0286788", "FBgn0286788", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1" ] }, "reaction_10427458": { "compartment": "compartment_70101", "id": "reaction_10427458", "reactome": "R-DME-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427454" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0286788", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10427408": { "compartment": "compartment_7660", "id": "reaction_10427408", "reactome": "R-DME-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427246" ], "products": [ "species_113582", "species_10427382", "species_10427384" ], "modifiers": [ [ "species_10427405", "catalyst" ] ], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "FBgn0286788", "Q9VSM9", "FBgn0035918", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q7JVY2", "FBgn0000996", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "P23573", "FBgn0004107" ] }, "reaction_10427456": { "compartment": "compartment_7660", "id": "reaction_10427456", "reactome": "R-DME-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427433" ], "products": [ "species_10427454" ], "modifiers": [], "additional_components": [ "FBgn0286788", "FBgn0286788" ] }, "reaction_10427487": { "compartment": "compartment_7660", "id": "reaction_10427487", "reactome": "R-DME-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10426924" ], "products": [ "species_113582", "species_10427473" ], "modifiers": [ [ "species_10427484", "catalyst" ] ], "additional_components": [ "FBgn0035918", "FBgn0035918", "P23573", "FBgn0004107", "P54733", "FBgn0010382" ] }, "reaction_10427591": { "compartment": "compartment_70101", "id": "reaction_10427591", "reactome": "R-DME-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427495" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSM9", "FBgn0035918", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10427589": { "compartment": "compartment_70101", "id": "reaction_10427589", "reactome": "R-DME-69015", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427489", "species_113592", "species_10426987" ], "products": [ "species_10427495" ], "modifiers": [ [ "species_10427586", "catalyst" ] ], "additional_components": [ "FBgn0035918", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSM9", "FBgn0035918", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699" ] }, "reaction_10427491": { "compartment": "compartment_7660", "id": "reaction_10427491", "reactome": "R-DME-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427473" ], "products": [ "species_10427489" ], "modifiers": [], "additional_components": [ "FBgn0035918", "FBgn0035918" ] }, "reaction_10427694": { "compartment": "compartment_7660", "id": "reaction_10427694", "reactome": "R-DME-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427682" ], "products": [ "species_10427686" ], "modifiers": [ [ "species_10427691", "catalyst" ] ], "additional_components": [ "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "FBgn0025832" ] }, "reaction_10427671": { "compartment": "compartment_7660", "id": "reaction_10427671", "reactome": "R-DME-69140", "name": "RPA binds to the Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_10427663" ], "products": [ "species_10427669" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10427684": { "compartment": "compartment_7660", "id": "reaction_10427684", "reactome": "R-DME-69144", "name": "Removal of RNA primer and dissociation of RPA and Dna2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427678" ], "products": [ "species_418075", "species_10427682", "species_10427667", "species_164121", "species_29626", "species_418076", "species_10427676" ], "modifiers": [], "additional_components": [ "Q8IRL9", "FBgn0030170", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0030170" ] }, "reaction_10427680": { "compartment": "compartment_7660", "id": "reaction_10427680", "reactome": "R-DME-69142", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427669", "species_10427676" ], "products": [ "species_10427678" ], "modifiers": [], "additional_components": [ "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0030170", "Q8IRL9", "FBgn0030170", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10427702": { "compartment": "compartment_7660", "id": "reaction_10427702", "reactome": "R-DME-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10427699", "catalyst" ] ], "additional_components": [ "FBgn0262619" ] }, "reaction_10427665": { "compartment": "compartment_7660", "id": "reaction_10427665", "reactome": "R-DME-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427661" ], "products": [ "species_10427663" ], "modifiers": [], "additional_components": [ "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655" ] }, "reaction_10427626": { "compartment": "compartment_7660", "id": "reaction_10427626", "reactome": "R-DME-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427460", "species_10427622" ], "products": [ "species_10427624" ], "modifiers": [], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113" ] }, "reaction_10427641": { "compartment": "compartment_7660", "id": "reaction_10427641", "reactome": "R-DME-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427635" ], "products": [ "species_10427622", "species_10427639" ], "modifiers": [], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655" ] }, "reaction_10427637": { "compartment": "compartment_7660", "id": "reaction_10427637", "reactome": "R-DME-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427633", "species_10427624" ], "products": [ "species_113582", "species_10427635" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655" ] }, "reaction_10438762": { "compartment": "compartment_7660", "id": "reaction_10438762", "reactome": "R-DME-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438753", "species_10438758", "species_10438743", "species_10438748" ], "products": [ "species_10438760" ], "modifiers": [], "additional_components": [ "FBgn0030196", "FBgn0039403", "FBgn0035194", "FBgn0261976", "Q9VQY9", "FBgn0261976", "Q9W0I7", "FBgn0035194", "Q9VBI1", "FBgn0039403", "Q9W2V7", "FBgn0030196" ] }, "reaction_10438063": { "compartment": "compartment_70101", "id": "reaction_10438063", "reactome": "R-DME-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427704", "species_10437645" ], "products": [ "species_10438061" ], "modifiers": [], "additional_components": [ "FBgn0004107", "P23573", "FBgn0004107" ] }, "reaction_10439454": { "compartment": "compartment_7660", "id": "reaction_10439454", "reactome": "R-DME-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438267" ], "products": [ "species_113582", "species_10427405" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10439452": { "compartment": "compartment_7660", "id": "reaction_10439452", "reactome": "R-DME-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438212" ], "products": [ "species_113582", "species_10438066" ], "modifiers": [ [ "species_10427405", "catalyst" ] ], "additional_components": [ "FBgn0262699", "FBgn0262699", "P23573", "FBgn0004107" ] }, "reaction_10439446": { "compartment": "compartment_7660", "id": "reaction_10439446", "reactome": "R-DME-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427755", "species_10438267" ], "products": [ "species_10439439" ], "modifiers": [ [ "species_10427755", "catalyst" ] ], "additional_components": [ "FBgn0010316", "P23573", "FBgn0004107", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "FBgn0010316" ] }, "reaction_10439444": { "compartment": "compartment_7660", "id": "reaction_10439444", "reactome": "R-DME-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10439439" ], "products": [ "species_113582", "species_10439441" ], "modifiers": [ [ "species_10439439", "catalyst" ] ], "additional_components": [ "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q7JNL9", "FBgn0010316", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107" ] }, "reaction_10438353": { "compartment": "compartment_7660", "id": "reaction_10438353", "reactome": "R-DME-174164", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438267" ], "products": [ "species_113582", "species_10438265" ], "modifiers": [ [ "species_10427726", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "FBgn0011737" ] }, "reaction_10438384": { "compartment": "compartment_13231", "id": "reaction_10438384", "reactome": "R-DME-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438061" ], "products": [ "species_10438267" ], "modifiers": [], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107" ] }, "reaction_10438272": { "compartment": "compartment_7660", "id": "reaction_10438272", "reactome": "R-DME-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10438265" ], "products": [ "species_113550", "species_10438267" ], "modifiers": [ [ "species_10438269", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10432407": { "compartment": "compartment_70101", "id": "reaction_10432407", "reactome": "R-DME-75825", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432405" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7KUZ5", "FBgn0010315", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10432403": { "compartment": "compartment_13231", "id": "reaction_10432403", "reactome": "R-DME-75823", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432386" ], "products": [ "species_10432395" ], "modifiers": [], "additional_components": [ "FBgn0010315", "FBgn0010315" ] }, "reaction_10432401": { "compartment": "compartment_13231", "id": "reaction_10432401", "reactome": "R-DME-75822", "name": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432393" ], "products": [ "species_10432399" ], "modifiers": [], "additional_components": [ "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10466073": { "compartment": "compartment_7660", "id": "reaction_10466073", "reactome": "R-DME-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466069", "species_113560" ], "products": [ "species_2485002", "species_10466071" ], "modifiers": [ [ "species_10466031", "catalyst" ] ], "additional_components": [ "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9VXE9", "FBgn0015615", "FBgn0035766" ] }, "reaction_10466036": { "compartment": "compartment_7660", "id": "reaction_10466036", "reactome": "R-DME-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466018", "species_113560" ], "products": [ "species_2485002", "species_10466026" ], "modifiers": [ [ "species_10466031", "catalyst" ] ], "additional_components": [ "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9VXE9", "FBgn0015615", "FBgn0035766" ] }, "reaction_10498336": { "compartment": "compartment_70101", "id": "reaction_10498336", "reactome": "R-DME-9656947", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498332" ], "products": [ "species_10498334" ], "modifiers": [], "additional_components": [ "FBgn0027864", "FBgn0027864" ] }, "reaction_10497794": { "compartment": "compartment_7660", "id": "reaction_10497794", "reactome": "R-DME-9629492", "name": "NEIL3 cleaves spiroiminodihydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497791" ], "products": [ "species_9629439", "species_10497784" ], "modifiers": [ [ "species_10497791", "catalyst" ] ], "additional_components": [ "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258" ] }, "reaction_10433945": { "compartment": "compartment_7660", "id": "reaction_10433945", "reactome": "R-DME-110243", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433940" ], "products": [ "species_10433942", "species_110242" ], "modifiers": [ [ "species_10433940", "catalyst" ] ], "additional_components": [ "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864" ] }, "reaction_10497787": { "compartment": "compartment_7660", "id": "reaction_10497787", "reactome": "R-DME-9629470", "name": "NEIL3 cleaves 5-guanidinohydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497782" ], "products": [ "species_10497784", "species_9629218" ], "modifiers": [ [ "species_10497782", "catalyst" ] ], "additional_components": [ "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258" ] }, "reaction_10433903": { "compartment": "compartment_7660", "id": "reaction_10433903", "reactome": "R-DME-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433898" ], "products": [ "species_110223", "species_10433900" ], "modifiers": [ [ "species_10433898", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10433950": { "compartment": "compartment_7660", "id": "reaction_10433950", "reactome": "R-DME-110244", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433947" ], "products": [ "species_10433942", "species_5636006" ], "modifiers": [ [ "species_10433947", "catalyst" ] ], "additional_components": [ "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864" ] }, "reaction_10433917": { "compartment": "compartment_7660", "id": "reaction_10433917", "reactome": "R-DME-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433914" ], "products": [ "species_30140", "species_10433900" ], "modifiers": [ [ "species_10433914", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10433883": { "compartment": "compartment_7660", "id": "reaction_10433883", "reactome": "R-DME-110219", "name": "Cleavage of thymine by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433880" ], "products": [ "species_10433873", "species_29692" ], "modifiers": [ [ "species_10433880", "catalyst" ] ], "additional_components": [ "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869" ] }, "reaction_10433931": { "compartment": "compartment_7660", "id": "reaction_10433931", "reactome": "R-DME-110234", "name": "Cleavage of ethenocytosine by TDG glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433928" ], "products": [ "species_10433873", "species_110233" ], "modifiers": [ [ "species_10433928", "catalyst" ] ], "additional_components": [ "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869" ] }, "reaction_10433894": { "compartment": "compartment_7660", "id": "reaction_10433894", "reactome": "R-DME-110221", "name": "Cleavage of uracil by SMUG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433887" ], "products": [ "species_10433891", "species_29554" ], "modifiers": [ [ "species_10433887", "catalyst" ] ], "additional_components": [ "Q9VEM1", "FBgn0038490", "Q9VEM1", "FBgn0038490", "Q9VEM1", "FBgn0038490" ] }, "reaction_10433910": { "compartment": "compartment_7660", "id": "reaction_10433910", "reactome": "R-DME-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433907" ], "products": [ "species_10433900", "species_110225" ], "modifiers": [ [ "species_10433907", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10433876": { "compartment": "compartment_7660", "id": "reaction_10433876", "reactome": "R-DME-110218", "name": "Cleavage of uracil by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433869" ], "products": [ "species_10433873", "species_29554" ], "modifiers": [ [ "species_10433869", "catalyst" ] ], "additional_components": [ "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869" ] }, "reaction_10433924": { "compartment": "compartment_7660", "id": "reaction_10433924", "reactome": "R-DME-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433921" ], "products": [ "species_5637659", "species_10433900" ], "modifiers": [ [ "species_10433921", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10474548": { "compartment": "compartment_7660", "id": "reaction_10474548", "reactome": "R-DME-5649681", "name": "NEIL2 cleaves 5-OHU from damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474543" ], "products": [ "species_10474545", "species_110216" ], "modifiers": [ [ "species_10474543", "catalyst" ] ], "additional_components": [ "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258" ] }, "reaction_10434063": { "compartment": "compartment_7660", "id": "reaction_10434063", "reactome": "R-DME-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434046" ], "products": [ "species_10434060" ], "modifiers": [ [ "species_10434046", "catalyst" ] ], "additional_components": [ "P27864", "FBgn0004584", "P27864", "FBgn0004584", "P27864", "FBgn0004584" ] }, "reaction_10434056": { "compartment": "compartment_7660", "id": "reaction_10434056", "reactome": "R-DME-110354", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433942", "species_10434044" ], "products": [ "species_10433936", "species_10434046" ], "modifiers": [], "additional_components": [ "Q9V3I8", "FBgn0027864", "FBgn0004584", "FBgn0027864", "P27864", "FBgn0004584" ] }, "reaction_10434054": { "compartment": "compartment_7660", "id": "reaction_10434054", "reactome": "R-DME-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433900", "species_10434044" ], "products": [ "species_10433865", "species_10434046" ], "modifiers": [], "additional_components": [ "Q9VIH0", "FBgn0032907", "FBgn0004584", "FBgn0032907", "P27864", "FBgn0004584" ] }, "reaction_10434052": { "compartment": "compartment_7660", "id": "reaction_10434052", "reactome": "R-DME-110351", "name": "Displacement of SMUG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434050", "species_10434044" ], "products": [ "species_10433860", "species_10434046" ], "modifiers": [], "additional_components": [ "Q9VEM1", "FBgn0038490", "FBgn0004584", "FBgn0038490", "P27864", "FBgn0004584" ] }, "reaction_10434048": { "compartment": "compartment_7660", "id": "reaction_10434048", "reactome": "R-DME-110350", "name": "Displacement of TDG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433873", "species_10434044" ], "products": [ "species_10434046", "species_10433855" ], "modifiers": [], "additional_components": [ "Q9V4D8", "FBgn0026869", "FBgn0004584", "P27864", "FBgn0004584", "FBgn0026869" ] }, "reaction_10474554": { "compartment": "compartment_7660", "id": "reaction_10474554", "reactome": "R-DME-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434060" ], "products": [ "species_10474552" ], "modifiers": [], "additional_components": [ "P27864", "FBgn0004584", "P27864", "FBgn0004584" ] }, "reaction_10434078": { "compartment": "compartment_7660", "id": "reaction_10434078", "reactome": "R-DME-110368", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10434075" ], "products": [ "species_10434071", "species_113541" ], "modifiers": [ [ "species_10434075", "catalyst" ] ], "additional_components": [ "P27864", "FBgn0004584", "Q7K7A9", "FBgn0025832", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P27864", "FBgn0004584", "Q7K7A9", "FBgn0025832", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P27864", "FBgn0004584", "Q7K7A9", "FBgn0025832", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10434086": { "compartment": "compartment_7660", "id": "reaction_10434086", "reactome": "R-DME-110371", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434082", "species_10427699" ], "products": [ "species_10434084" ], "modifiers": [], "additional_components": [ "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "FBgn0262619", "Q9W1H4", "FBgn0262619", "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10474561": { "compartment": "compartment_7660", "id": "reaction_10474561", "reactome": "R-DME-5651805", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434084" ], "products": [ "species_10474558" ], "modifiers": [ [ "species_10434084", "catalyst" ] ], "additional_components": [ "Q9W1H4", "FBgn0262619", "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P27864", "FBgn0004584", "Q9W1H4", "FBgn0262619", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q9W1H4", "FBgn0262619", "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10432365": { "compartment": "compartment_7660", "id": "reaction_10432365", "reactome": "R-DME-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432356", "species_10432361" ], "products": [ "species_10432363" ], "modifiers": [], "additional_components": [ "FBgn0034728", "FBgn0020270", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728" ] }, "reaction_10468909": { "compartment": "compartment_7660", "id": "reaction_10468909", "reactome": "R-DME-3785768", "name": "MRN complex binds DNA double strand breaks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75165", "species_10432372" ], "products": [ "species_10468907" ], "modifiers": [], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476443": { "compartment": "compartment_70101", "id": "reaction_10476443", "reactome": "R-DME-5684008", "name": "NBN binds KPNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476433", "species_10476435" ], "products": [ "species_10476437" ], "modifiers": [], "additional_components": [ "FBgn0267727", "FBgn0261530", "Q9VT40", "FBgn0261530", "P52295", "FBgn0267727" ] }, "reaction_10476441": { "compartment": "compartment_7660", "id": "reaction_10476441", "reactome": "R-DME-5684006", "name": "KPNA2 translocates NBN to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476437" ], "products": [ "species_10432370", "species_10476439" ], "modifiers": [], "additional_components": [ "Q9VT40", "FBgn0261530", "P52295", "FBgn0267727", "FBgn0261530", "FBgn0267727" ] }, "reaction_10432374": { "compartment": "compartment_7660", "id": "reaction_10432374", "reactome": "R-DME-75174", "name": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432370", "species_10432363" ], "products": [ "species_10432372" ], "modifiers": [], "additional_components": [ "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476320": { "compartment": "compartment_7660", "id": "reaction_10476320", "reactome": "R-DME-5682044", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10476315" ], "products": [ "species_2485002", "species_10476317" ], "modifiers": [ [ "species_10476315", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080" ] }, "reaction_10476396": { "compartment": "compartment_7660", "id": "reaction_10476396", "reactome": "R-DME-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10476391" ], "products": [ "species_113582", "species_10427797" ], "modifiers": [ [ "species_10476391", "catalyst" ] ], "additional_components": [ "O61267", "FBgn0019686", "FBgn0019686", "O61267", "FBgn0019686" ] }, "reaction_10476393": { "compartment": "compartment_7660", "id": "reaction_10476393", "reactome": "R-DME-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476389" ], "products": [ "species_10476391" ], "modifiers": [], "additional_components": [ "FBgn0019686", "O61267", "FBgn0019686" ] }, "reaction_10478112": { "compartment": "compartment_7660", "id": "reaction_10478112", "reactome": "R-DME-5693598", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10478100" ], "products": [ "species_113582", "species_10476458" ], "modifiers": [ [ "species_10478100", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080" ] }, "reaction_10476764": { "compartment": "compartment_7660", "id": "reaction_10476764", "reactome": "R-DME-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10476754" ], "products": [ "species_68454", "species_10476761", "species_10427691" ], "modifiers": [ [ "species_10476754", "catalyst" ] ], "additional_components": [ "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "FBgn0025832", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476728": { "compartment": "compartment_7660", "id": "reaction_10476728", "reactome": "R-DME-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10476721" ], "products": [ "species_30555", "species_10476725" ], "modifiers": [ [ "species_10476721", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476743": { "compartment": "compartment_7660", "id": "reaction_10476743", "reactome": "R-DME-5687484", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476725", "species_10474568", "species_10427691", "species_10476735" ], "products": [ "species_10476741" ], "modifiers": [], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "FBgn0025832", "O18475", "FBgn0002905", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "P35875", "FBgn0010247", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476757": { "compartment": "compartment_7660", "id": "reaction_10476757", "reactome": "R-DME-5687653", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10476749" ], "products": [ "species_427497", "species_10476754", "species_10474566", "species_10476735" ], "modifiers": [ [ "species_10476749", "catalyst" ] ], "additional_components": [ "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "O18475", "FBgn0002905", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247" ] }, "reaction_10476752": { "compartment": "compartment_7660", "id": "reaction_10476752", "reactome": "R-DME-5687640", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10476741" ], "products": [ "species_113541", "species_10476749" ], "modifiers": [ [ "species_10476741", "catalyst" ] ], "additional_components": [ "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "P35875", "FBgn0010247", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "P35875", "FBgn0010247", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476768": { "compartment": "compartment_7660", "id": "reaction_10476768", "reactome": "R-DME-5687673", "name": "MRN recruits LIG3:XRCC1 to MMEJ sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434098", "species_10476761" ], "products": [ "species_10476766" ], "modifiers": [], "additional_components": [ "Q9Y095", "FBgn0026751", "Q9VG84", "FBgn0286075", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9Y095", "FBgn0026751", "Q9VG84", "FBgn0286075" ] }, "reaction_10476783": { "compartment": "compartment_7660", "id": "reaction_10476783", "reactome": "R-DME-5687758", "name": "PPP4C:PPP4R2 dephosphorylates RPA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10476563" ], "products": [ "species_113550", "species_10427667" ], "modifiers": [ [ "species_10476780", "catalyst" ] ], "additional_components": [ "Q24492", "FBgn0010173", "Q9VYW3", "FBgn0266421", "Q9VIH1", "FBgn0032906", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W2U4", "FBgn0030208", "O76932", "FBgn0023177" ] }, "reaction_10476631": { "compartment": "compartment_7660", "id": "reaction_10476631", "reactome": "R-DME-5686430", "name": "MUS81 binds EME1, EME2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476616", "species_10476623" ], "products": [ "species_10476629" ], "modifiers": [], "additional_components": [ "FBgn0033549", "FBgn0040347", "Q9V3T1", "FBgn0040347", "A1Z8C0", "FBgn0033549" ] }, "reaction_10476647": { "compartment": "compartment_7660", "id": "reaction_10476647", "reactome": "R-DME-5686475", "name": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476643", "species_10476629" ], "products": [ "species_10476645" ], "modifiers": [], "additional_components": [ "Q9VN41", "FBgn0037263", "Q9VS48", "FBgn0002909", "Q9V3T1", "FBgn0040347", "A1Z8C0", "FBgn0033549", "Q9V3T1", "FBgn0040347", "A1Z8C0", "FBgn0033549", "Q9VN41", "FBgn0037263", "Q9VS48", "FBgn0002909" ] }, "reaction_10476597": { "compartment": "compartment_7660", "id": "reaction_10476597", "reactome": "R-DME-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476592", "species_29358" ], "products": [ "species_113582", "species_10476595" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "FBgn0003479", "FBgn0003479", "FBgn0261278" ] }, "reaction_10479290": { "compartment": "compartment_7660", "id": "reaction_10479290", "reactome": "R-DME-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479283", "species_6781829" ], "products": [ "species_10479287", "species_113541" ], "modifiers": [ [ "species_10479283", "catalyst" ] ], "additional_components": [ "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10479322": { "compartment": "compartment_7660", "id": "reaction_10479322", "reactome": "R-DME-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479302", "species_10427430" ], "products": [ "species_10479319" ], "modifiers": [ [ "species_10479302", "catalyst" ] ], "additional_components": [ "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962" ] }, "reaction_10479304": { "compartment": "compartment_7660", "id": "reaction_10479304", "reactome": "R-DME-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479300", "species_10479294" ], "products": [ "species_10479302", "species_10477930" ], "modifiers": [], "additional_components": [ "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057" ] }, "reaction_10479285": { "compartment": "compartment_7660", "id": "reaction_10479285", "reactome": "R-DME-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431174", "species_10429254", "species_5688114" ], "products": [ "species_10479283" ], "modifiers": [], "additional_components": [ "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10479365": { "compartment": "compartment_7660", "id": "reaction_10479365", "reactome": "R-DME-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479356" ], "products": [ "species_10479362", "species_10427430" ], "modifiers": [ [ "species_10479356", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366" ] }, "reaction_10479390": { "compartment": "compartment_7660", "id": "reaction_10479390", "reactome": "R-DME-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433815", "species_10479386" ], "products": [ "species_10479388" ], "modifiers": [], "additional_components": [ "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10479406": { "compartment": "compartment_7660", "id": "reaction_10479406", "reactome": "R-DME-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479388" ], "products": [ "species_10479392" ], "modifiers": [ [ "species_10479388", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P20232", "FBgn0010422", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P28518", "FBgn0004832", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10479376": { "compartment": "compartment_7660", "id": "reaction_10479376", "reactome": "R-DME-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10479362" ], "products": [ "species_113550", "species_113582", "species_10479373" ], "modifiers": [ [ "species_10479362", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962" ] }, "reaction_10479402": { "compartment": "compartment_7660", "id": "reaction_10479402", "reactome": "R-DME-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10479397" ], "products": [ "species_10479399", "species_113541" ], "modifiers": [ [ "species_10479397", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366" ] }, "reaction_10479413": { "compartment": "compartment_7660", "id": "reaction_10479413", "reactome": "R-DME-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479399" ], "products": [ "species_10479408", "species_10477658" ], "modifiers": [ [ "species_10479410", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W1H4", "FBgn0262619", "Q9Y095", "FBgn0026751", "Q9VG84", "FBgn0286075" ] }, "reaction_10477876": { "compartment": "compartment_7660", "id": "reaction_10477876", "reactome": "R-DME-5691001", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477873", "species_30555" ], "products": [ "species_113541", "species_10477869" ], "modifiers": [ [ "species_10477873", "catalyst" ] ], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10479228": { "compartment": "compartment_7660", "id": "reaction_10479228", "reactome": "R-DME-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479224", "species_427523" ], "products": [ "species_427497", "species_10477240" ], "modifiers": [], "additional_components": [ "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698" ] }, "reaction_10477880": { "compartment": "compartment_7660", "id": "reaction_10477880", "reactome": "R-DME-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477878", "species_5688114", "species_10477932" ], "products": [ "species_10477930", "species_10477934" ], "modifiers": [ [ "species_10477169", "catalyst" ] ], "additional_components": [ "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "Q24595", "FBgn0004698", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "Q24595", "FBgn0004698", "Q7K012", "FBgn0025716", "Q9Y0Z1", "FBgn0027503", "Q8ST83", "FBgn0002521", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "Q9W3D4", "FBgn0040929", "Q9VH07", "FBgn0040078", "A1Z6E8", "FBgn0033019", "A1Z8D5", "FBgn0033566", "Q9VX09", "FBgn0030877", "Q9VFH4", "FBgn0086686", "Q9VEC3", "FBgn0038576", "Q4V604", "FBgn0052202", "Q9VDY1", "FBgn0086613", "Q9VZJ3", "FBgn0263832" ] }, "reaction_10477871": { "compartment": "compartment_7660", "id": "reaction_10477871", "reactome": "R-DME-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431174", "species_10477240" ], "products": [ "species_10477242" ], "modifiers": [], "additional_components": [ "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10477865": { "compartment": "compartment_7660", "id": "reaction_10477865", "reactome": "R-DME-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10477858" ], "products": [ "species_113550", "species_113582", "species_10477862" ], "modifiers": [ [ "species_10477858", "catalyst" ] ], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P28518", "FBgn0004832", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P28518", "FBgn0004832" ] }, "reaction_10433817": { "compartment": "compartment_7660", "id": "reaction_10433817", "reactome": "R-DME-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433808", "species_10433813" ], "products": [ "species_10433815" ], "modifiers": [], "additional_components": [ "FBgn0028434", "FBgn0002707", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10480324": { "compartment": "compartment_7660", "id": "reaction_10480324", "reactome": "R-DME-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480310", "species_10477862" ], "products": [ "species_10467222", "species_10480319" ], "modifiers": [ [ "species_10480321", "catalyst" ] ], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "FBgn0010602", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q24595", "FBgn0004698", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O97102", "FBgn0264922", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832" ] }, "reaction_10477248": { "compartment": "compartment_7660", "id": "reaction_10477248", "reactome": "R-DME-5689861", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477221", "species_10477242" ], "products": [ "species_10431137", "species_10477246" ], "modifiers": [], "additional_components": [ "FBgn0004832", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P28518", "FBgn0004832" ] }, "reaction_10477856": { "compartment": "compartment_7660", "id": "reaction_10477856", "reactome": "R-DME-5690991", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433815", "species_10477849" ], "products": [ "species_10477851" ], "modifiers": [], "additional_components": [ "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10477854": { "compartment": "compartment_7660", "id": "reaction_10477854", "reactome": "R-DME-5690990", "name": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477851" ], "products": [ "species_10477652" ], "modifiers": [ [ "species_10477851", "catalyst" ] ], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10477662": { "compartment": "compartment_7660", "id": "reaction_10477662", "reactome": "R-DME-5690213", "name": "DNA polymerases delta, epsilon or kappa bind the GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434065", "species_10477652", "species_10477654", "species_10427622" ], "products": [ "species_10477660" ], "modifiers": [], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P35875", "FBgn0010247", "P28518", "FBgn0004832" ] }, "reaction_10475262": { "compartment": "compartment_7660", "id": "reaction_10475262", "reactome": "R-DME-5655466", "name": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475257" ], "products": [ "species_10427430", "species_10475255", "species_10475259" ], "modifiers": [ [ "species_10475257", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476" ] }, "reaction_10474603": { "compartment": "compartment_7660", "id": "reaction_10474603", "reactome": "R-DME-5652005", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474580", "species_10474599" ], "products": [ "species_10474601" ], "modifiers": [], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10475271": { "compartment": "compartment_7660", "id": "reaction_10475271", "reactome": "R-DME-5655483", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475255" ], "products": [ "species_10475266", "species_10475268", "species_10475253" ], "modifiers": [ [ "species_10475255", "catalyst" ] ], "additional_components": [ "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "FBgn0028476", "FBgn0028476", "FBgn0033607", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476" ] }, "reaction_10474608": { "compartment": "compartment_7660", "id": "reaction_10474608", "reactome": "R-DME-5652009", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10474601" ], "products": [ "species_10434065", "species_10474599", "species_10474605" ], "modifiers": [ [ "species_10474601", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10475264": { "compartment": "compartment_7660", "id": "reaction_10475264", "reactome": "R-DME-5655481", "name": "USP1:WDR48 binds monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475255", "species_10474605" ], "products": [ "species_10475257" ], "modifiers": [], "additional_components": [ "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476" ] }, "reaction_10475290": { "compartment": "compartment_7660", "id": "reaction_10475290", "reactome": "R-DME-5655892", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475281", "species_30555" ], "products": [ "species_10475287", "species_113541" ], "modifiers": [ [ "species_10475281", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150" ] }, "reaction_10475299": { "compartment": "compartment_7660", "id": "reaction_10475299", "reactome": "R-DME-5655965", "name": "POLK and POLZ cooperate in elongation of mispaired primer termini", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10475287" ], "products": [ "species_10475296", "species_10433955", "species_10433993", "species_113541" ], "modifiers": [ [ "species_10475287", "catalyst" ] ], "additional_components": [ "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "species_266099", "species_29926", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150" ] }, "reaction_10433981": { "compartment": "compartment_7660", "id": "reaction_10433981", "reactome": "R-DME-110308", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433970", "species_30185" ], "products": [ "species_10433978" ], "modifiers": [ [ "species_10433970", "catalyst" ] ], "additional_components": [ "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10434039": { "compartment": "compartment_7660", "id": "reaction_10434039", "reactome": "R-DME-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433986", "species_10433991" ], "products": [ "species_10433993" ], "modifiers": [], "additional_components": [ "FBgn0002891", "FBgn0037345", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891" ] }, "reaction_10433972": { "compartment": "compartment_7660", "id": "reaction_10433972", "reactome": "R-DME-110307", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433968", "species_10433955" ], "products": [ "species_10433970" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0035150", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10474610": { "compartment": "compartment_7660", "id": "reaction_10474610", "reactome": "R-DME-5652151", "name": "REV1 recruits POLZ to (AP:Cyt)-DNA Template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433993", "species_10433978" ], "products": [ "species_10433995" ], "modifiers": [], "additional_components": [ "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891" ] }, "reaction_10434002": { "compartment": "compartment_7660", "id": "reaction_10434002", "reactome": "R-DME-110311", "name": "POLZ extends translesion synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10433995" ], "products": [ "species_10433993", "species_113541", "species_10433999" ], "modifiers": [ [ "species_10433995", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891" ] }, "reaction_10475337": { "compartment": "compartment_7660", "id": "reaction_10475337", "reactome": "R-DME-5656158", "name": "POLZ elongates POLI-incorporated dNMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10475325" ], "products": [ "species_10433955", "species_10475334", "species_10433993", "species_113541" ], "modifiers": [ [ "species_10475325", "catalyst" ] ], "additional_components": [ "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "FBgn0035150", "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150" ] }, "reaction_10475319": { "compartment": "compartment_7660", "id": "reaction_10475319", "reactome": "R-DME-5656105", "name": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475315", "species_10433955", "species_10433993", "species_10475311" ], "products": [ "species_10475317" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9VHV1", "FBgn0037554", "species_29926", "Q9VHV1", "FBgn0037554", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10475328": { "compartment": "compartment_7660", "id": "reaction_10475328", "reactome": "R-DME-5656148", "name": "POLI incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10475317" ], "products": [ "species_113541", "species_10475325" ], "modifiers": [ [ "species_10475317", "catalyst" ] ], "additional_components": [ "Q9VHV1", "FBgn0037554", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "Q9VHV1", "FBgn0037554", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10474686": { "compartment": "compartment_7660", "id": "reaction_10474686", "reactome": "R-DME-5653838", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434065", "species_10474682" ], "products": [ "species_10474684" ], "modifiers": [], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10474680": { "compartment": "compartment_7660", "id": "reaction_10474680", "reactome": "R-DME-5653780", "name": "USP43 binds ISG:K164,ISG:K168-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474672", "species_10474676" ], "products": [ "species_10474678" ], "modifiers": [], "additional_components": [ "FBgn0050421", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q9W117", "FBgn0050421" ] }, "reaction_10434030": { "compartment": "compartment_7660", "id": "reaction_10434030", "reactome": "R-DME-110317", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29604", "species_10434013" ], "products": [ "species_113541", "species_10434027" ], "modifiers": [ [ "species_10434013", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141" ] }, "reaction_10475228": { "compartment": "compartment_7660", "id": "reaction_10475228", "reactome": "R-DME-5654989", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10475219" ], "products": [ "species_113582", "species_10434007", "species_10475225" ], "modifiers": [ [ "species_10475219", "catalyst" ] ], "additional_components": [ "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784", "FBgn0037141", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784" ] }, "reaction_10475243": { "compartment": "compartment_7660", "id": "reaction_10475243", "reactome": "R-DME-5655170", "name": "RCHY1 monoubiquitinates POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10475230" ], "products": [ "species_10434018", "species_10475240" ], "modifiers": [ [ "species_10475230", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VNX1", "FBgn0037141", "Q9VMD4", "FBgn0031816", "FBgn0031816", "Q9VNX1", "FBgn0037141", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VNX1", "FBgn0037141", "Q9VMD4", "FBgn0031816" ] }, "reaction_10475223": { "compartment": "compartment_7660", "id": "reaction_10475223", "reactome": "R-DME-5654986", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434034", "species_10475199" ], "products": [ "species_10475201" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "FBgn0267977", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141" ] }, "reaction_10434037": { "compartment": "compartment_7660", "id": "reaction_10434037", "reactome": "R-DME-110319", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10434027" ], "products": [ "species_10434034", "species_113541" ], "modifiers": [ [ "species_10434027", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141" ] }, "reaction_10475221": { "compartment": "compartment_7660", "id": "reaction_10475221", "reactome": "R-DME-5654985", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475217", "species_10475201" ], "products": [ "species_10475219" ], "modifiers": [], "additional_components": [ "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784" ] }, "reaction_10434020": { "compartment": "compartment_7660", "id": "reaction_10434020", "reactome": "R-DME-110316", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434007", "species_10434011" ], "products": [ "species_10434013" ], "modifiers": [ [ "species_10434018", "inhibitor" ] ], "additional_components": [ "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "FBgn0031816" ] }, "reaction_10475232": { "compartment": "compartment_7660", "id": "reaction_10475232", "reactome": "R-DME-5655142", "name": "RCHY1 binds POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434018", "species_10434007" ], "products": [ "species_10475230" ], "modifiers": [], "additional_components": [ "FBgn0031816", "FBgn0037141", "Q9VNX1", "FBgn0037141", "Q9VMD4", "FBgn0031816" ] }, "reaction_10479709": { "compartment": "compartment_7660", "id": "reaction_10479709", "reactome": "R-DME-6785594", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479700", "species_10479705" ], "products": [ "species_10479707" ], "modifiers": [], "additional_components": [ "FBgn0038827", "FBgn0033354", "A1Z7L1", "FBgn0033354", "Q8MYL1", "FBgn0038827" ] }, "reaction_10449934": { "compartment": "compartment_876", "id": "reaction_10449934", "reactome": "R-DME-444008", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_114523", "species_74113" ], "products": [ "species_209914", "species_83910", "species_352022" ], "modifiers": [ [ "species_10449931", "catalyst" ] ], "additional_components": [ "FBgn0010414" ] }, "reaction_10445846": { "compartment": "compartment_5460", "id": "reaction_10445846", "reactome": "R-DME-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10429091", "catalyst" ] ], "additional_components": [ "Q9VLC5", "FBgn0012036" ] }, "reaction_10444860": { "compartment": "compartment_984", "id": "reaction_10444860", "reactome": "R-DME-374919", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10497879": { "compartment": "compartment_876", "id": "reaction_10497879", "reactome": "R-DME-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444352", "species_9634838" ], "products": [ "species_10444355" ], "modifiers": [], "additional_components": [ "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943", "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943" ] }, "reaction_10444357": { "compartment": "compartment_984", "id": "reaction_10444357", "reactome": "R-DME-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10444352", "catalyst" ], [ "species_10444355", "inhibitor" ] ], "additional_components": [ "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943", "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943" ] }, "reaction_10486033": { "compartment": "compartment_7660", "id": "reaction_10486033", "reactome": "R-DME-6804468", "name": "PIAS1 SUMOylates SP3 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467290", "species_10467901" ], "products": [ "species_10486031", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q9VPQ5", "FBgn0043364", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "M9PJG1", "FBgn0020378", "Q24266", "FBgn0000233", "Q2MGN0", "FBgn0034946", "Q9VPQ5", "FBgn0043364", "FBgn0010602", "FBgn0003612" ] }, "reaction_10470035": { "compartment": "compartment_7660", "id": "reaction_10470035", "reactome": "R-DME-4641350", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470028" ], "products": [ "species_10470033", "species_10467222" ], "modifiers": [ [ "species_10469560", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0284220", "FBgn0284220", "FBgn0010602", "FBgn0003612" ] }, "reaction_10470128": { "compartment": "compartment_70101", "id": "reaction_10470128", "reactome": "R-DME-4655355", "name": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470071" ], "products": [ "species_10470093", "species_10470095" ], "modifiers": [ [ "species_10469818", "catalyst" ], [ "species_10470125", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q7JRJ9", "FBgn0260991", "Q9VLD6", "FBgn0032105", "Q9VLD7", "FBgn0032104", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VLD7", "FBgn0032104", "Q9VLD6", "FBgn0032105", "Q7JRJ9", "FBgn0260991", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "FBgn0010602", "FBgn0003612", "A1YK02", "FBgn0034310", "A1Z8P9", "FBgn0013756", "Q9VE85", "FBgn0038609", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VCH5", "FBgn0039120", "Q9VBU8", "FBgn0039301", "Q9V466", "FBgn0027868", "Q9VCW3", "FBgn0039004", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "A1Z6H7", "FBgn0266580", "Q8IQV9", "FBgn0031078", "Q7K0D8", "FBgn0033264", "Q7KNM2", "FBgn0010602", "Q9VIW3", "FBgn0003346", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9VWS2", "FBgn0030943", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VFE7", "FBgn0038274", "Q7K2X8", "FBgn0033247", "Q9VXE6", "FBgn0061200", "Q9V463", "FBgn0021761" ] }, "reaction_10470191": { "compartment": "compartment_7660", "id": "reaction_10470191", "reactome": "R-DME-4755524", "name": "SUMOylation of NR1I2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10470184" ], "products": [ "species_10467222", "species_10470189" ], "modifiers": [], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "Q24143", "FBgn0015240", "CHEBI:28077", "FBgn0010602", "Q24143", "FBgn0015240", "CHEBI:28077" ] }, "reaction_10470143": { "compartment": "compartment_7660", "id": "reaction_10470143", "reactome": "R-DME-4719413", "name": "PIAS2,3,4 SUMOylate RORA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445281", "species_10467290" ], "products": [ "species_10467222", "species_10470138" ], "modifiers": [ [ "species_10470140", "catalyst" ] ], "additional_components": [ "P45447", "FBgn0004865", "P31396", "FBgn0000448", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "P45447", "FBgn0004865", "P31396", "FBgn0000448", "FBgn0003612" ] }, "reaction_10469820": { "compartment": "compartment_7660", "id": "reaction_10469820", "reactome": "R-DME-4546385", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445316", "species_10467290" ], "products": [ "species_10467222", "species_10469816" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0001078", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "FBgn0001078", "FBgn0003612" ] }, "reaction_10470156": { "compartment": "compartment_7660", "id": "reaction_10470156", "reactome": "R-DME-4719448", "name": "PIAS1 SUMOylates THRB with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10445311" ], "products": [ "species_10467222", "species_10470154" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "FBgn0000568", "FBgn0010602", "FBgn0000568", "FBgn0003612" ] }, "reaction_10470167": { "compartment": "compartment_7660", "id": "reaction_10470167", "reactome": "R-DME-4720432", "name": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470158" ], "products": [ "species_10470164", "species_10467222" ], "modifiers": [ [ "species_10469978", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:1301", "CHEBI:34310", "CHEBI:1301", "P34021", "FBgn0000546", "FBgn0010602", "FBgn0041210" ] }, "reaction_10469718": { "compartment": "compartment_7660", "id": "reaction_10469718", "reactome": "R-DME-4341072", "name": "SUMOylation of RARA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445299", "species_10467290" ], "products": [ "species_10469715", "species_10467222" ], "modifiers": [ [ "species_10467290", "catalyst" ] ], "additional_components": [ "FBgn0000568", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0000568", "FBgn0010602", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10470149": { "compartment": "compartment_7660", "id": "reaction_10470149", "reactome": "R-DME-4719423", "name": "PIAS2-2 SUMOylates THRA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10445309" ], "products": [ "species_10470147", "species_10467222" ], "modifiers": [ [ "species_10470140", "catalyst" ] ], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "FBgn0000568", "FBgn0000568", "FBgn0010602", "FBgn0003612" ] }, "reaction_10469826": { "compartment": "compartment_7660", "id": "reaction_10469826", "reactome": "R-DME-4546387", "name": "PIAS4 SUMOylates VDR with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445234", "species_10467290" ], "products": [ "species_10467222", "species_10469823" ], "modifiers": [ [ "species_10469560", "catalyst" ] ], "additional_components": [ "FBgn0015240", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "FBgn0015240", "FBgn0003612" ] }, "reaction_10470176": { "compartment": "compartment_7660", "id": "reaction_10470176", "reactome": "R-DME-4720446", "name": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470169" ], "products": [ "species_10467222", "species_10470174" ], "modifiers": [ [ "species_10469978", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:1301", "FBgn0010602", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:1301", "FBgn0041210" ] }, "reaction_10470211": { "compartment": "compartment_7660", "id": "reaction_10470211", "reactome": "R-DME-4755536", "name": "PIAS3 SUMOylates RELA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470193", "species_10467298" ], "products": [ "species_10470209", "species_10467222" ], "modifiers": [ [ "species_10469818", "catalyst" ] ], "additional_components": [ "P98149", "Dif", "P15330", "dl", "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "P98149", "Dif", "P15330", "dl", "FBgn0010602", "FBgn0003612" ] }, "reaction_10469909": { "compartment": "compartment_7660", "id": "reaction_10469909", "reactome": "R-DME-4570499", "name": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429333", "species_10467290" ], "products": [ "species_10469907", "species_10467222" ], "modifiers": [ [ "species_10467488", "catalyst" ] ], "additional_components": [ "FBgn0267791", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0267791", "FBgn0010602", "P26017", "FBgn0003042", "Q9VB08", "FBgn0003330", "Q9VHA0", "FBgn0003334", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "P39769", "FBgn0004861", "Q9VKL0", "FBgn0032330", "Q9W523", "FBgn0004860" ] }, "reaction_10469904": { "compartment": "compartment_7660", "id": "reaction_10469904", "reactome": "R-DME-4570489", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467290", "species_10469898" ], "products": [ "species_10467222", "species_10469902" ], "modifiers": [ [ "species_10467290", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0026196", "FBgn0010602", "FBgn0026196", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469992": { "compartment": "compartment_7660", "id": "reaction_10469992", "reactome": "R-DME-4615987", "name": "RANBP2 SUMOylates HDAC4 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469978" ], "products": [ "species_10469989", "species_10467222" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0041210", "FBgn0041210", "FBgn0010602", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10469973": { "compartment": "compartment_7660", "id": "reaction_10469973", "reactome": "R-DME-4615839", "name": "PIAS1 SUMOylates SATB1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10444232" ], "products": [ "species_10469971", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0020307", "FBgn0020307", "FBgn0010602", "FBgn0003612" ] }, "reaction_10486044": { "compartment": "compartment_7660", "id": "reaction_10486044", "reactome": "R-DME-6804485", "name": "PIAS1 SUMOylates L3MBTL2 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486038", "species_10467290" ], "products": [ "species_10486042", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0032475", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0032475", "FBgn0010602", "FBgn0003612" ] }, "reaction_10469986": { "compartment": "compartment_7660", "id": "reaction_10469986", "reactome": "R-DME-4615900", "name": "PIAS1 SUMOylates SATB2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10469980" ], "products": [ "species_10469984", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "FBgn0020307", "FBgn0020307", "FBgn0010602", "FBgn0003612" ] }, "reaction_10467179": { "compartment": "compartment_7660", "id": "reaction_10467179", "reactome": "R-DME-2990842", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467152" ], "products": [ "species_10467154" ], "modifiers": [ [ "species_10467176", "catalyst" ] ], "additional_components": [ "FBgn0264922", "FBgn0264922", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110" ] }, "reaction_10467217": { "compartment": "compartment_7660", "id": "reaction_10467217", "reactome": "R-DME-2993763", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467213" ], "products": [ "species_10467215" ], "modifiers": [ [ "species_10467176", "catalyst" ] ], "additional_components": [ "FBgn0264922", "FBgn0264922", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110" ] }, "reaction_10493344": { "compartment": "compartment_7660", "id": "reaction_10493344", "reactome": "R-DME-8943817", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493338", "species_10493336" ], "products": [ "species_10493342" ], "modifiers": [], "additional_components": [ "Q8I7Z8", "FBgn0045852", "Q8I7Z8", "FBgn0045852" ] }, "reaction_10493329": { "compartment": "compartment_7660", "id": "reaction_10493329", "reactome": "R-DME-8943780", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493323", "species_10493319" ], "products": [ "species_10493327" ], "modifiers": [], "additional_components": [ "Q94517", "HDAC1", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q24572", "FBgn0263979", "Q9VKH3", "FBgn0000287", "P39770", "FBgn0261648", "Q9VKH3", "FBgn0000287", "P39770", "FBgn0261648", "Q94517", "HDAC1", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q24572", "FBgn0263979" ] }, "reaction_10493377": { "compartment": "compartment_13231", "id": "reaction_10493377", "reactome": "R-DME-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493368" ], "products": [ "species_10493366" ], "modifiers": [ [ "species_10437040", "inhibitor" ] ], "additional_components": [ "FBgn0267861", "FBgn0267861", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10493375": { "compartment": "compartment_70101", "id": "reaction_10493375", "reactome": "R-DME-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10493368" ], "products": [ "species_10493373", "species_29370" ], "modifiers": [ [ "species_10437040", "catalyst" ] ], "additional_components": [ "FBgn0267861", "FBgn0267861", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10467806": { "compartment": "compartment_70101", "id": "reaction_10467806", "reactome": "R-DME-3228469", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10450922" ], "products": [ "species_10450883", "species_29370" ], "modifiers": [ [ "species_10467790", "catalyst" ] ], "additional_components": [ "FBgn0261524", "FBgn0261524", "FBgn0014006" ] }, "reaction_10467802": { "compartment": "compartment_70101", "id": "reaction_10467802", "reactome": "R-DME-3225851", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467792", "species_1250243" ], "products": [ "species_10430994", "species_10467790" ], "modifiers": [ [ "species_10467796", "catalyst" ] ], "additional_components": [ "Q9VDS9", "FBgn0014006", "Q9V429", "FBgn0040070", "FBgn0040070", "FBgn0014006" ] }, "reaction_10495401": { "compartment": "compartment_7660", "id": "reaction_10495401", "reactome": "R-DME-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495397", "species_111793" ], "products": [ "species_10495399" ], "modifiers": [], "additional_components": [ "FBgn0260749", "species_111793", "Q9VL07", "FBgn0260749" ] }, "reaction_10467889": { "compartment": "compartment_7660", "id": "reaction_10467889", "reactome": "R-DME-3240957", "name": "Formation of PRC2-EZH2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458993", "species_10467875", "species_10467880", "species_10467885" ], "products": [ "species_10467887" ], "modifiers": [], "additional_components": [ "FBgn0263979", "FBgn0032391", "FBgn0000629", "FBgn0020887", "Q9NJG9", "FBgn0020887", "P42124", "FBgn0000629", "Q9VKD5", "FBgn0032391", "Q24572", "FBgn0263979" ] }, "reaction_10473727": { "compartment": "compartment_13949", "id": "reaction_10473727", "reactome": "R-DME-5623524", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473705", "species_10473723" ], "products": [ "species_10473725" ], "modifiers": [], "additional_components": [ "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "species_29438", "O18335", "FBgn0015790", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9V8K2", "FBgn0266671", "Q9VQQ9", "FBgn0266670", "Q9VVG4", "FBgn0266669", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VDE6", "FBgn0266674", "Q9XTM1", "FBgn0266673", "Q9VNH6", "FBgn0266672", "Q9V8K2", "FBgn0266671", "Q9VQQ9", "FBgn0266670", "Q9VVG4", "FBgn0266669", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VDE6", "FBgn0266674", "Q9XTM1", "FBgn0266673", "Q9VNH6", "FBgn0266672", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "species_29438", "O18335", "FBgn0015790", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145" ] }, "reaction_10473635": { "compartment": "compartment_70101", "id": "reaction_10473635", "reactome": "R-DME-5623508", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10473633" ], "products": [ "species_29420", "species_10473517" ], "modifiers": [ [ "species_10444051", "catalyst" ] ], "additional_components": [ "P40945", "FBgn0013749", "species_29420", "P40945", "FBgn0013749", "species_29438", "FBgn0264560" ] }, "reaction_10473683": { "compartment": "compartment_20699", "id": "reaction_10473683", "reactome": "R-DME-5623513", "name": "ASAP1 stimulates GTPase activity of ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10473678" ], "products": [ "species_10473680", "species_10473633", "species_29372" ], "modifiers": [ [ "species_10473678", "catalyst" ] ], "additional_components": [ "O18335", "FBgn0015790", "species_29438", "M9ND89", "FBgn0013718", "P40945", "FBgn0013749", "A1Z7A6", "FBgn0050372", "O18335", "FBgn0015790", "species_29438", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "P40945", "FBgn0013749", "species_29420", "O18335", "FBgn0015790", "species_29438", "M9ND89", "FBgn0013718", "P40945", "FBgn0013749", "A1Z7A6", "FBgn0050372" ] }, "reaction_10473745": { "compartment": "compartment_261122", "id": "reaction_10473745", "reactome": "R-DME-5623527", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473725" ], "products": [ "species_10473743" ], "modifiers": [], "additional_components": [ "Q9V8K2", "FBgn0266671", "Q9VQQ9", "FBgn0266670", "Q9VVG4", "FBgn0266669", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VDE6", "FBgn0266674", "Q9XTM1", "FBgn0266673", "Q9VNH6", "FBgn0266672", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "species_29438", "O18335", "FBgn0015790", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145" ] }, "reaction_10433822": { "compartment": "compartment_70101", "id": "reaction_10433822", "reactome": "R-DME-110133", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500077" ], "products": [ "species_113592", "species_500071" ], "modifiers": [ [ "species_10431187", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:28862", "species_5696194", "CHEBI:16192", "FBgn0036099" ] }, "reaction_10452894": { "compartment": "compartment_70101", "id": "reaction_10452894", "reactome": "R-DME-482621", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_482625" ], "products": [ "species_113592", "species_482627" ], "modifiers": [ [ "species_10452889", "catalyst" ] ], "additional_components": [ "species_29892", "species_29604", "species_30185", "species_29494", "species_30187", "species_110577", "species_500739", "species_29438", "species_205687", "CHEBI:28846", "CHEBI:16174", "species_29420", "CHEBI:28850", "CHEBI:28862", "CHEBI:18075", "species_110094", "P08879", "FBgn0000150" ] }, "reaction_10480029": { "compartment": "compartment_7660", "id": "reaction_10480029", "reactome": "R-DME-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6788813" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10480026", "catalyst" ] ], "additional_components": [ "CHEBI:15918", "species_1524067", "species_76577", "species_109386", "species_110094", "CHEBI:16174", "CHEBI:28846", "species_29370", "FBgn0033754" ] }, "reaction_10432346": { "compartment": "compartment_70101", "id": "reaction_10432346", "reactome": "R-DME-75126", "name": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_499999" ], "products": [ "species_499997", "species_113592" ], "modifiers": [ [ "species_10430985", "catalyst" ] ], "additional_components": [ "CHEBI:28850", "CHEBI:18075", "species_109382", "species_109366", "A1ZB29", "FBgn0034299" ] }, "reaction_10432344": { "compartment": "compartment_70101", "id": "reaction_10432344", "reactome": "R-DME-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500006" ], "products": [ "species_500009", "species_113592" ], "modifiers": [ [ "species_10430860", "catalyst" ] ], "additional_components": [ "species_205687", "CHEBI:28846", "species_110094", "species_1524067", "CHEBI:15918", "species_418075", "Q9VBI2", "FBgn0028833" ] }, "reaction_10480021": { "compartment": "compartment_5460", "id": "reaction_10480021", "reactome": "R-DME-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6788802" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10480018", "catalyst" ] ], "additional_components": [ "species_1524067", "species_109386", "species_76577", "CHEBI:15918", "species_29370", "CHEBI:16174", "CHEBI:28846", "species_110094", "FBgn0042094" ] }, "reaction_10486254": { "compartment": "compartment_70101", "id": "reaction_10486254", "reactome": "R-DME-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6806885" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10486251", "catalyst" ] ], "additional_components": [ "P08879", "FBgn0000150" ] }, "reaction_10431502": { "compartment": "compartment_70101", "id": "reaction_10431502", "reactome": "R-DME-74220", "name": "(d)AMP + ATP <=> (d)ADP + ADP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500088", "species_113592" ], "products": [ "species_29370", "species_500087" ], "modifiers": [ [ "species_10431499", "catalyst" ] ], "additional_components": [ "species_76577", "species_109386", "species_29370", "CHEBI:16174", "Q8IQG9", "FBgn0022709" ] }, "reaction_10453058": { "compartment": "compartment_70101", "id": "reaction_10453058", "reactome": "R-DME-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10453055", "catalyst" ] ], "additional_components": [ "Q9VUL1", "FBgn0266452" ] }, "reaction_10433850": { "compartment": "compartment_70101", "id": "reaction_10433850", "reactome": "R-DME-110145", "name": "AMP + ATP <=> ADP + ADP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76577" ], "products": [ "species_29370" ], "modifiers": [ [ "species_10433845", "catalyst" ] ], "additional_components": [ "FBgn0283494" ] }, "reaction_10434170": { "compartment": "compartment_70101", "id": "reaction_10434170", "reactome": "R-DME-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_8866401" ], "products": [ "species_10430994", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10434167", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "species_1222611", "P48592", "FBgn0011704", "P48591", "FBgn0011703" ] }, "reaction_10431033": { "compartment": "compartment_7660", "id": "reaction_10431033", "reactome": "R-DME-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10431030", "catalyst" ] ], "additional_components": [ "Q9V3I1", "FBgn0250837" ] }, "reaction_10430962": { "compartment": "compartment_70101", "id": "reaction_10430962", "reactome": "R-DME-73605", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355", "species_109382" ], "products": [ "species_109366", "species_73604" ], "modifiers": [ [ "species_10430959", "catalyst" ] ], "additional_components": [ "O76511", "FBgn0024920", "species_29926" ] }, "reaction_10434161": { "compartment": "compartment_70101", "id": "reaction_10434161", "reactome": "R-DME-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_8866401" ], "products": [ "species_10430994", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10434158", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "P48592", "FBgn0011704", "species_1222611", "P48591", "FBgn0011703" ] }, "reaction_10431023": { "compartment": "compartment_70101", "id": "reaction_10431023", "reactome": "R-DME-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10431020", "catalyst" ] ], "additional_components": [ "Q9VUL1", "FBgn0266452" ] }, "reaction_10433838": { "compartment": "compartment_70101", "id": "reaction_10433838", "reactome": "R-DME-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10433833", "catalyst" ] ], "additional_components": [ "species_76577", "species_1524067", "CHEBI:15918", "species_109386", "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "Q8IQG9", "FBgn0022709", "M9PCF9", "FBgn0032083" ] }, "reaction_10433836": { "compartment": "compartment_70101", "id": "reaction_10433836", "reactome": "R-DME-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10433833", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "species_76577", "species_1524067", "CHEBI:15918", "species_109386", "Q8IQG9", "FBgn0022709", "M9PCF9", "FBgn0032083" ] }, "reaction_10453032": { "compartment": "compartment_5460", "id": "reaction_10453032", "reactome": "R-DME-482812", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113581", "species_482807" ], "products": [ "species_113593", "species_482803" ], "modifiers": [ [ "species_10453027", "catalyst" ] ], "additional_components": [ "species_110577", "species_29438", "species_500739", "species_29892", "species_29494", "species_29604", "species_30185", "species_30187", "CHEBI:18075", "species_29420", "CHEBI:28850", "CHEBI:28862", "species_205687", "CHEBI:16174", "CHEBI:28846", "species_110094", "P08879", "FBgn0000150" ] }, "reaction_10480797": { "compartment": "compartment_7660", "id": "reaction_10480797", "reactome": "R-DME-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480711" ], "products": [ "species_10480770" ], "modifiers": [ [ "species_10480794", "catalyst" ], [ "species_10480430", "catalyst" ], [ "species_10480782", "catalyst" ], [ "species_10480418", "catalyst" ] ], "additional_components": [ "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VGZ2", "FBgn0037815", "Q9VK19", "FBgn0032487", "Q8IPX7", "FBgn0260648", "Q9W1M9", "FBgn0034879", "Q9VKJ4", "FBgn0032346", "Q8T4A9", "FBgn0030789", "Q29QQ9", "FBgn0034065", "Q9VW53", "FBgn0036916", "Q9VFF3", "FBgn0038269", "Q9VXL4", "FBgn0030711", "Q95PE4", "FBgn0032921", "Q9Y134", "FBgn0001986", "FBgn0038269", "FBgn0037815", "FBgn0001986" ] }, "reaction_10480745": { "compartment": "compartment_7660", "id": "reaction_10480745", "reactome": "R-DME-6791221", "name": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480707" ], "products": [ "species_10480711" ], "modifiers": [ [ "species_10480713", "catalyst" ], [ "species_10430268", "catalyst" ], [ "species_10480715", "catalyst" ], [ "species_10480694", "catalyst" ], [ "species_10480689", "catalyst" ], [ "species_10480683", "catalyst" ], [ "species_10480681", "catalyst" ], [ "species_10480546", "catalyst" ], [ "species_10480630", "catalyst" ], [ "species_10480717", "catalyst" ], [ "species_10480719", "catalyst" ], [ "species_10480721", "catalyst" ], [ "species_10480723", "catalyst" ], [ "species_10480725", "catalyst" ], [ "species_10480727", "catalyst" ], [ "species_10480729", "catalyst" ], [ "species_10480731", "catalyst" ], [ "species_10480733", "catalyst" ], [ "species_10480738", "catalyst" ], [ "species_10480679", "catalyst" ], [ "species_10480743", "catalyst" ] ], "additional_components": [ "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "FBgn0039300", "FBgn0004867", "FBgn0261596", "FBgn0036886", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "FBgn0010408", "FBgn0039757", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "FBgn0010520", "FBgn0034743", "FBgn0033912", "FBgn0010265", "FBgn0017545", "FBgn0002590", "FBgn0030136", "FBgn0010198", "FBgn0039713", "FBgn0033699", "FBgn0030720", "FBgn0261592", "FBgn0039233" ] }, "reaction_10480933": { "compartment": "compartment_7660", "id": "reaction_10480933", "reactome": "R-DME-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480919" ], "products": [ "species_10480923" ], "modifiers": [ [ "species_10480928", "catalyst" ], [ "species_10480546", "catalyst" ], [ "species_10480595", "catalyst" ], [ "species_10480931", "catalyst" ], [ "species_10480571", "catalyst" ], [ "species_10480694", "catalyst" ], [ "species_10480418", "catalyst" ] ], "additional_components": [ "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "FBgn0031868", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "FBgn0003742", "FBgn0262560", "FBgn0036886", "FBgn0001986" ] }, "reaction_10480467": { "compartment": "compartment_7660", "id": "reaction_10480467", "reactome": "R-DME-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480451" ], "products": [ "species_10480408" ], "modifiers": [ [ "species_10480465", "catalyst" ], [ "species_10480449", "catalyst" ], [ "species_10480395", "catalyst" ], [ "species_10480400", "catalyst" ] ], "additional_components": [ "Q8SZY9", "FBgn0052075", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110", "Q9W3K4", "FBgn0029999", "Q8MS38", "FBgn0053217", "Q9W550", "FBgn0023514", "Q9VKQ3", "FBgn0032298", "Q9VL96", "FBgn0032138", "Q7K0Y1", "FBgn0028744", "A1ZA92", "FBgn0034073", "Q8SZY9", "FBgn0052075", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110", "Q9W3K4", "FBgn0029999", "Q8MS38", "FBgn0053217", "Q9W550", "FBgn0023514", "A1ZA92", "FBgn0034073", "Q8MT06", "FBgn0038473", "Q9V9Z9", "FBgn0039828", "Q9VL96", "FBgn0032138", "Q9VKQ3", "FBgn0032298", "Q9VL96", "FBgn0032138", "Q7K0Y1", "FBgn0028744", "FBgn0052075", "FBgn0034073" ] }, "reaction_10468641": { "compartment": "compartment_7660", "id": "reaction_10468641", "reactome": "R-DME-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468620", "species_10468637" ], "products": [ "species_10468639" ], "modifiers": [], "additional_components": [ "P22813", "FBgn0001222", "Q9VK90", "FBgn0032429", "Q9VK90", "FBgn0032429", "P22813", "FBgn0001222" ] }, "reaction_10493657": { "compartment": "compartment_70101", "id": "reaction_10493657", "reactome": "R-DME-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493653" ], "products": [ "species_10493655" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493663": { "compartment": "compartment_70101", "id": "reaction_10493663", "reactome": "R-DME-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718", "species_10493632" ], "products": [ "species_10493653" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_350388": { "compartment": "compartment_70101", "id": "reaction_350388", "reactome": "R-DME-350388", "name": "ROK binds to activated RHO1:GTP", "reversible": "false", "notes": "Rho-kinase (ROK) aka Drok binds to activated Rho GTPase (RHO1:GTP) and is itself activated. The conserved Rho-binding site in ROK is the area of interaction.", "reactants": [ "species_450801", "species_350932" ], "products": [ "species_450785" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641", "Q9U779", "ROK", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_350391": { "compartment": "compartment_876", "id": "reaction_350391", "reactome": "R-DME-350391", "name": "RHO1:GTP binds to activated DAAM", "reversible": "false", "notes": "Activated Rho GTPase (RHO1:GTP) binds to activated Dishevelled Associated Activator of Morphogenesis (DAAM) complexed to Dishevelled (DSH). DAAM is a bridging factor between DSH and RHO1.", "reactants": [ "species_450703", "species_350950" ], "products": [ "species_450801" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641", "species_29438", "P48148", "Rho1", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_350396": { "compartment": "compartment_70101", "id": "reaction_350396", "reactome": "R-DME-350396", "name": "DSH binds to DAAM", "reversible": "false", "notes": "Dishevelled Associated Activator of Morphogenesis (DAAM) is autoinhibited by intramolecular interactions between its GBD and DAD domains. Dishevelled (DSH) binds to the DAD domain of DAAM and disrupts the autoinhibitory interaction, thus activating DAAM.", "reactants": [ "species_351034", "species_450734" ], "products": [ "species_450703" ], "modifiers": [], "additional_components": [ "FBgn0025641", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_10470444": { "compartment": "compartment_7660", "id": "reaction_10470444", "reactome": "R-DME-5159250", "name": "ATF7IP binds SETDB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470435", "species_10470440" ], "products": [ "species_10470442" ], "modifiers": [], "additional_components": [ "FBgn0027499", "FBgn0086908", "Q32KD2", "FBgn0086908", "Q7KMH9", "FBgn0027499" ] }, "reaction_10495537": { "compartment": "compartment_876", "id": "reaction_10495537", "reactome": "R-DME-8981353", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495534" ], "products": [ "species_10438980", "species_10439352" ], "modifiers": [ [ "species_10495534", "catalyst" ], [ "species_10488125", "inhibitor" ] ], "additional_components": [ "Q8IR23", "FBgn0003969", "species_29438", "P08646", "RAS85D", "P08646", "RAS85D", "species_29420", "FBgn0003969", "Q8IR23", "FBgn0003969", "species_29438", "P08646", "RAS85D", "Q9VX32", "RhoGAPp190", "Q8IR23", "FBgn0003969" ] }, "reaction_10495540": { "compartment": "compartment_876", "id": "reaction_10495540", "reactome": "R-DME-8981355", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10439352" ], "products": [ "species_10495534" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "FBgn0003969", "Q8IR23", "FBgn0003969", "species_29438", "P08646", "RAS85D" ] }, "reaction_10487958": { "compartment": "compartment_876", "id": "reaction_10487958", "reactome": "R-DME-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464321", "species_29438" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10487955", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "Q9XYM0", "FBgn0024811", "Q9VKB2", "FBgn0032409", "Q2PDT4", "FBgn0041789" ] }, "reaction_10488121": { "compartment": "compartment_70101", "id": "reaction_10488121", "reactome": "R-DME-8849082", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488118" ], "products": [ "species_29372", "species_10434904", "species_10488116" ], "modifiers": [ [ "species_10488118", "catalyst" ] ], "additional_components": [ "Q9VX32", "RhoGAPp190", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420", "Q9VX32", "RhoGAPp190", "P48148", "Rho1", "species_29438" ] }, "reaction_10488123": { "compartment": "compartment_70101", "id": "reaction_10488123", "reactome": "R-DME-8849085", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434906", "species_10488116" ], "products": [ "species_10488118" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "Q9VX32", "RhoGAPp190", "P48148", "Rho1", "species_29438" ] }, "reaction_10488127": { "compartment": "compartment_70101", "id": "reaction_10488127", "reactome": "R-DME-8849094", "name": "ARHGAP35 binds RASA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439352", "species_10488116" ], "products": [ "species_10488125" ], "modifiers": [], "additional_components": [ "FBgn0003969", "Q9VX32", "RhoGAPp190", "Q8IR23", "FBgn0003969" ] }, "reaction_10487964": { "compartment": "compartment_70101", "id": "reaction_10487964", "reactome": "R-DME-8848829", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454432", "species_10426987" ], "products": [ "species_10487961" ], "modifiers": [ [ "species_10454432", "catalyst" ] ], "additional_components": [ "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0020224", "FBgn0020224" ] }, "reaction_10488040": { "compartment": "compartment_7660", "id": "reaction_10488040", "reactome": "R-DME-8848993", "name": "Phosphorylated KHDRBS1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488022" ], "products": [ "species_10488038" ], "modifiers": [], "additional_components": [ "O44434", "FBgn0022984", "Q9W240", "FBgn0034739", "Q9W254", "FBgn0022985", "Q9W2D0", "FBgn0034659", "Q9W224", "FBgn0034740", "Q9W249", "FBgn0034731", "Q9W255", "FBgn0022986", "Q9W254", "FBgn0022985", "Q9W255", "FBgn0022986", "Q9W2D0", "FBgn0034659", "O44434", "FBgn0022984", "Q9W224", "FBgn0034740", "Q9W240", "FBgn0034739", "Q9W249", "FBgn0034731" ] }, "reaction_10469023": { "compartment": "compartment_876", "id": "reaction_10469023", "reactome": "R-DME-3791155", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443411" ], "products": [ "species_10469021" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "P11046", "FBgn0261800", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "FBgn0035049" ] }, "reaction_10479128": { "compartment": "compartment_5460", "id": "reaction_10479128", "reactome": "R-DME-5696408", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696409", "species_113521" ], "products": [ "species_113548", "species_5693978", "species_113556" ], "modifiers": [ [ "species_10479125", "catalyst" ] ], "additional_components": [ "Q9VU95", "FBgn0036381" ] }, "reaction_10466188": { "compartment": "compartment_984", "id": "reaction_10466188", "reactome": "R-DME-2534248", "name": "DCN (decorin) degradation by MMP2, MMP3, MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465552" ], "products": [ "species_10466183", "species_10466185" ], "modifiers": [ [ "species_10459266", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "FBgn0028872", "FBgn0035049" ] }, "reaction_10459276": { "compartment": "compartment_984", "id": "reaction_10459276", "reactome": "R-DME-1454781", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459252", "species_10459247" ], "products": [ "species_10459274" ], "modifiers": [], "additional_components": [ "FBgn0035049", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9W122", "FBgn0035049" ] }, "reaction_10469689": { "compartment": "compartment_876", "id": "reaction_10469689", "reactome": "R-DME-4224014", "name": "E-cadherin degradation by ADAM10, ADAM15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469032" ], "products": [ "species_10469040", "species_10469036" ], "modifiers": [ [ "species_10469686", "catalyst" ] ], "additional_components": [ "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "Q6QU65", "FBgn0265140", "Q9VJW9", "FBgn0259984" ] }, "reaction_10460413": { "compartment": "compartment_984", "id": "reaction_10460413", "reactome": "R-DME-1604690", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460226" ], "products": [ "species_10459272", "species_10460411" ], "modifiers": [ [ "species_10459252", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460058": { "compartment": "compartment_984", "id": "reaction_10460058", "reactome": "R-DME-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460055" ], "products": [ "species_10459252" ], "modifiers": [ [ "species_10459266", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460378": { "compartment": "compartment_17963", "id": "reaction_10460378", "reactome": "R-DME-1602484", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460376" ], "products": [ "species_10459260" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0004509" ] }, "reaction_10460185": { "compartment": "compartment_984", "id": "reaction_10460185", "reactome": "R-DME-1592316", "name": "Initial activation of proMMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460060" ], "products": [ "species_10460064", "species_10460062" ], "modifiers": [ [ "species_10460182", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "Q9VUG2", "FBgn0036436", "P13582", "ProEA", "Q9I7V4", "FBgn0042098", "M9NDV6", "FBgn0036817", "Q9VUF0", "FBgn0036427", "Q8MLV8", "FBgn0050287", "C5WLM7", "FBgn0050414", "Q9VR15", "FBgn0031619", "Q9W2C8", "FBgn0034661", "Q8IRK6", "FBgn0050288", "A1ZA44", "FBgn0050083", "Q9VK10", "FBgn0284244", "Q9VZS9", "FBgn0053160", "Q8IRK5", "FBgn0050289", "A1ZA38", "FBgn0050088", "Q9VA87", "FBgn0039759", "Q9VXC7", "FBgn0030775", "Q7KVM8", "FBgn0069056", "A0A4D6K1E7", "FBgn0039272", "Q9VA44", "FBgn0039798", "Q9VWD8", "FBgn0031058", "Q7KVM3", "FBgn0034666", "Q9V3Z2", "FBgn0037515" ] }, "reaction_10460409": { "compartment": "compartment_876", "id": "reaction_10460409", "reactome": "R-DME-1604368", "name": "Autocatalytic activation of bound proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460396" ], "products": [ "species_10460050", "species_10460406" ], "modifiers": [ [ "species_10460396", "catalyst" ] ], "additional_components": [ "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10460374": { "compartment": "compartment_984", "id": "reaction_10460374", "reactome": "R-DME-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460062" ], "products": [ "species_10460371", "species_10460055" ], "modifiers": [ [ "species_10460062", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460053": { "compartment": "compartment_984", "id": "reaction_10460053", "reactome": "R-DME-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460048" ], "products": [ "species_10460050", "species_10459266" ], "modifiers": [ [ "species_10460048", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460437": { "compartment": "compartment_984", "id": "reaction_10460437", "reactome": "R-DME-1604741", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460380" ], "products": [ "species_10460435", "species_10460422" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460403": { "compartment": "compartment_876", "id": "reaction_10460403", "reactome": "R-DME-1604360", "name": "Initial activation of proMMP2 by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460388" ], "products": [ "species_10460392", "species_10460396" ], "modifiers": [ [ "species_10460187", "catalyst" ], [ "species_10460401", "inhibitor" ] ], "additional_components": [ "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "FBgn0035049", "FBgn0026562" ] }, "reaction_10460433": { "compartment": "compartment_984", "id": "reaction_10460433", "reactome": "R-DME-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460422" ], "products": [ "species_10459254", "species_10460426" ], "modifiers": [ [ "species_10460422", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460369": { "compartment": "compartment_17963", "id": "reaction_10460369", "reactome": "R-DME-1602466", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460353" ], "products": [ "species_10460367" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9W122", "FBgn0035049", "Q9W122", "FBgn0035049", "FBgn0004509" ] }, "reaction_10460559": { "compartment": "compartment_17963", "id": "reaction_10460559", "reactome": "R-DME-1605825", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460367" ], "products": [ "species_10460557" ], "modifiers": [], "additional_components": [ "Q9W122", "FBgn0035049", "Q9W122", "FBgn0035049" ] }, "reaction_10460334": { "compartment": "compartment_984", "id": "reaction_10460334", "reactome": "R-DME-1602454", "name": "proMMP9 binds TIMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460224", "species_10452419" ], "products": [ "species_10460332" ], "modifiers": [], "additional_components": [ "FBgn0035049", "FBgn0025879", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10460460": { "compartment": "compartment_984", "id": "reaction_10460460", "reactome": "R-DME-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460380" ], "products": [ "species_10460439", "species_10460424" ], "modifiers": [ [ "species_10460457", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q9W122", "FBgn0035049" ] }, "reaction_10460394": { "compartment": "compartment_984", "id": "reaction_10460394", "reactome": "R-DME-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460386" ], "products": [ "species_10460048", "species_10460392" ], "modifiers": [ [ "species_10459252", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460231": { "compartment": "compartment_984", "id": "reaction_10460231", "reactome": "R-DME-1592436", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460224" ], "products": [ "species_10460226", "species_10460228" ], "modifiers": [ [ "species_10459252", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460390": { "compartment": "compartment_876", "id": "reaction_10460390", "reactome": "R-DME-1604350", "name": "MMP14:TIMP2 binds proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460386", "species_10460191" ], "products": [ "species_10460388" ], "modifiers": [], "additional_components": [ "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10460420": { "compartment": "compartment_984", "id": "reaction_10460420", "reactome": "R-DME-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460197" ], "products": [ "species_10460417", "species_10459256" ], "modifiers": [ [ "species_10460197", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460193": { "compartment": "compartment_876", "id": "reaction_10460193", "reactome": "R-DME-1592349", "name": "MMP14 (MT1-MMP) binds TIMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460187", "species_10460189" ], "products": [ "species_10460191" ], "modifiers": [], "additional_components": [ "FBgn0035049", "FBgn0025879", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10469030": { "compartment": "compartment_984", "id": "reaction_10469030", "reactome": "R-DME-3791319", "name": "NID1 degradation by MMP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465781" ], "products": [ "species_10469025", "species_10469027" ], "modifiers": [ [ "species_10459264", "catalyst" ] ], "additional_components": [ "FBgn0000119", "FBgn0000119", "FBgn0000119", "FBgn0035049" ] }, "reaction_10466181": { "compartment": "compartment_876", "id": "reaction_10466181", "reactome": "R-DME-2533950", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451" ], "products": [ "species_10459980" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "FBgn0035049" ] }, "reaction_10469045": { "compartment": "compartment_876", "id": "reaction_10469045", "reactome": "R-DME-3828025", "name": "DCN (decorin) degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465552" ], "products": [ "species_10466183", "species_10466185" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "FBgn0028872", "FBgn0035049" ] }, "reaction_10468964": { "compartment": "compartment_876", "id": "reaction_10468964", "reactome": "R-DME-3788061", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451" ], "products": [ "species_10468949" ], "modifiers": [ [ "species_10468961", "catalyst" ] ], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140" ] }, "reaction_10469043": { "compartment": "compartment_876", "id": "reaction_10469043", "reactome": "R-DME-3827958", "name": "E-cadherin degradation by MMP9, KLK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469032" ], "products": [ "species_10469040", "species_10469036" ], "modifiers": [ [ "species_10459272", "catalyst" ] ], "additional_components": [ "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "FBgn0035049" ] }, "reaction_10460002": { "compartment": "compartment_984", "id": "reaction_10460002", "reactome": "R-DME-1566981", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451" ], "products": [ "species_10459980" ], "modifiers": [ [ "species_10459999", "catalyst" ] ], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q9W122", "FBgn0035049" ] }, "reaction_10434812": { "compartment": "compartment_7660", "id": "reaction_10434812", "reactome": "R-DME-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434771", "species_10434653" ], "products": [ "species_10434773" ], "modifiers": [], "additional_components": [ "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10434778": { "compartment": "compartment_7660", "id": "reaction_10434778", "reactome": "R-DME-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434658", "species_10429250", "species_10431174" ], "products": [ "species_10434771", "species_10431174" ], "modifiers": [ [ "species_10434658", "catalyst" ] ], "additional_components": [ "FBgn0035026", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "FBgn0035026" ] }, "reaction_10434810": { "compartment": "compartment_7660", "id": "reaction_10434810", "reactome": "R-DME-113402", "name": "Formation of DSIF:NELF:early elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434773", "species_10434646", "species_30595" ], "products": [ "species_10434775", "species_30595" ], "modifiers": [], "additional_components": [ "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "species_110577", "species_113592", "species_29494", "species_29438" ] }, "reaction_10446741": { "compartment": "compartment_70101", "id": "reaction_10446741", "reactome": "R-DME-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446737", "species_10446693" ], "products": [ "species_10446739" ], "modifiers": [], "additional_components": [ "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "FBgn0030300", "Q9VYY8", "FBgn0030300", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019" ] }, "reaction_10487280": { "compartment": "compartment_70101", "id": "reaction_10487280", "reactome": "R-DME-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487278" ], "products": [ "species_29372", "species_10487272" ], "modifiers": [], "additional_components": [ "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_113592", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105" ] }, "reaction_10488352": { "compartment": "compartment_70101", "id": "reaction_10488352", "reactome": "R-DME-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488348", "species_10488332" ], "products": [ "species_10488350" ], "modifiers": [], "additional_components": [ "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927" ] }, "reaction_10487330": { "compartment": "compartment_70101", "id": "reaction_10487330", "reactome": "R-DME-6814409", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487328" ], "products": [ "species_29370", "species_10487289" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "FBgn0036519", "FBgn0036519", "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10488356": { "compartment": "compartment_70101", "id": "reaction_10488356", "reactome": "R-DME-8850534", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488354" ], "products": [ "species_10488332", "species_10487289" ], "modifiers": [], "additional_components": [ "Q9VUR7", "FBgn0036519", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "FBgn0036519" ] }, "reaction_10488360": { "compartment": "compartment_70101", "id": "reaction_10488360", "reactome": "R-DME-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488350" ], "products": [ "species_10446737", "species_10488358" ], "modifiers": [], "additional_components": [ "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W3J1", "FBgn0030011", "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927" ] }, "reaction_10487274": { "compartment": "compartment_70101", "id": "reaction_10487274", "reactome": "R-DME-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434577", "species_10446737" ], "products": [ "species_10487272" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105" ] }, "reaction_10488330": { "compartment": "compartment_70101", "id": "reaction_10488330", "reactome": "R-DME-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488328" ], "products": [ "species_10446737", "species_10487334" ], "modifiers": [], "additional_components": [ "P29829", "FBgn0004623", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9VUR7", "FBgn0036519", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "Q9VUR7", "FBgn0036519" ] }, "reaction_10487340": { "compartment": "compartment_70101", "id": "reaction_10487340", "reactome": "R-DME-6814418", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434560", "species_10487334" ], "products": [ "species_10487338" ], "modifiers": [], "additional_components": [ "P38040", "FBgn0004921", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "Q9VUR7", "FBgn0036519", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VUR7", "FBgn0036519" ] }, "reaction_10488364": { "compartment": "compartment_70101", "id": "reaction_10488364", "reactome": "R-DME-8850560", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487338", "species_10434215" ], "products": [ "species_10488362", "species_10487289" ], "modifiers": [], "additional_components": [ "P29829", "FBgn0004623", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VUR7", "FBgn0036519", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P38040", "FBgn0004921", "FBgn0036519" ] }, "reaction_10487293": { "compartment": "compartment_70101", "id": "reaction_10487293", "reactome": "R-DME-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487289", "species_10487272" ], "products": [ "species_10487291" ], "modifiers": [], "additional_components": [ "FBgn0036519", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9VUR7", "FBgn0036519" ] }, "reaction_10487295": { "compartment": "compartment_70101", "id": "reaction_10487295", "reactome": "R-DME-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487272" ], "products": [ "species_10487278", "species_29370" ], "modifiers": [], "additional_components": [ "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_113592", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105" ] }, "reaction_10435035": { "compartment": "compartment_70101", "id": "reaction_10435035", "reactome": "R-DME-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435028", "species_114520" ], "products": [ "species_10435030" ], "modifiers": [], "additional_components": [ "P29993", "FBgn0010051", "species_114520", "species_74016", "P29993", "FBgn0010051" ] }, "reaction_10448282": { "compartment": "compartment_876", "id": "reaction_10448282", "reactome": "R-DME-426209", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448278", "species_114519" ], "products": [ "species_10448280" ], "modifiers": [], "additional_components": [ "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "species_114519", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861" ] }, "reaction_10448164": { "compartment": "compartment_70101", "id": "reaction_10448164", "reactome": "R-DME-425861", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440788", "species_114519" ], "products": [ "species_10448162" ], "modifiers": [], "additional_components": [ "P83099", "FBgn0259680", "P13678", "FBgn0003093", "species_114519", "P83099", "FBgn0259680", "P13678", "FBgn0003093" ] }, "reaction_10448320": { "compartment": "compartment_70101", "id": "reaction_10448320", "reactome": "R-DME-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10448317", "catalyst" ] ], "additional_components": [ "Q7K579", "FBgn0020930", "A8JQ65", "FBgn0085413", "Q09103", "FBgn0261549", "Q01583", "FBgn0085390" ] }, "reaction_10492391": { "compartment": "compartment_7660", "id": "reaction_10492391", "reactome": "R-DME-8938231", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447242", "species_10489794" ], "products": [ "species_10492389" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617" ] }, "reaction_10435599": { "compartment": "compartment_70101", "id": "reaction_10435599", "reactome": "R-DME-156910", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435585", "species_10435590", "species_10435595" ], "products": [ "species_10435597" ], "modifiers": [], "additional_components": [ "FBgn0028737", "FBgn0032198", "FBgn0029176", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737" ] }, "reaction_10435616": { "compartment": "compartment_70101", "id": "reaction_10435616", "reactome": "R-DME-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10435612" ], "products": [ "species_10435614" ], "modifiers": [], "additional_components": [ "FBgn0000559", "P13060", "FBgn0000559", "species_29438" ] }, "reaction_10435606": { "compartment": "compartment_70101", "id": "reaction_10435606", "reactome": "R-DME-156913", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10435601", "species_10435597" ], "products": [ "species_10435603", "species_10435580" ], "modifiers": [ [ "species_10435597", "catalyst" ] ], "additional_components": [ "P08736", "FBgn0284245", "P05303", "FBgn0000557", "species_29420", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737", "species_29420", "P08736", "FBgn0284245", "P05303", "FBgn0000557", "species_29438", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737" ] }, "reaction_10498785": { "compartment": "compartment_7660", "id": "reaction_10498785", "reactome": "R-DME-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1254400", "species_10492512" ], "products": [ "species_10492514" ], "modifiers": [], "additional_components": [ "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "species_374146" ] }, "reaction_10492498": { "compartment": "compartment_7660", "id": "reaction_10492498", "reactome": "R-DME-8939201", "name": "ESR dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492488" ], "products": [ "species_10492496" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "species_374146", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10492518": { "compartment": "compartment_7660", "id": "reaction_10492518", "reactome": "R-DME-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492508", "species_1254400" ], "products": [ "species_10492510" ], "modifiers": [], "additional_components": [ "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "species_374146", "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592" ] }, "reaction_10497254": { "compartment": "compartment_7660", "id": "reaction_10497254", "reactome": "R-DME-9038029", "name": "27-hydroxysterol binds ESR1, ESR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445260", "species_9024328" ], "products": [ "species_10497252" ], "modifiers": [], "additional_components": [ "FBgn0035849", "species_9024328", "Q8WS79", "FBgn0035849" ] }, "reaction_10495875": { "compartment": "compartment_7660", "id": "reaction_10495875", "reactome": "R-DME-9008270", "name": "NCOA1 binds ESR1:estrogen:TGFA gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495867", "species_10440440" ], "products": [ "species_10495873" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "FBgn0041092", "M9ND53", "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974" ] }, "reaction_10495879": { "compartment": "compartment_7660", "id": "reaction_10495879", "reactome": "R-DME-9008285", "name": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495869", "species_10458126" ], "products": [ "species_10495877" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092", "FBgn0261617", "M9MS40", "FBgn0261617", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092" ] }, "reaction_10496935": { "compartment": "compartment_7660", "id": "reaction_10496935", "reactome": "R-DME-9023840", "name": "HATs and coactivators are recruited to the CTSD gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476674", "species_10496924", "species_10445380", "species_10465316", "species_10496931", "species_10458126", "species_10496929" ], "products": [ "species_10496933" ], "modifiers": [], "additional_components": [ "FBgn0041092", "species_374146", "Q8WS79", "FBgn0035849", "FBgn0037109", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "FBgn0029711", "FBgn0261617", "FBgn0029711", "Q9W4J8", "FBgn0029711", "M9MS40", "FBgn0261617", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "Q9VP05", "FBgn0037109", "species_374146", "Q8WS79", "FBgn0035849", "M9ND53", "FBgn0041092" ] }, "reaction_10496587": { "compartment": "compartment_7660", "id": "reaction_10496587", "reactome": "R-DME-9018499", "name": "ESR1:ESTG and EP300 are recruited to TFF3 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496583", "species_10458587", "species_10458126" ], "products": [ "species_10496585" ], "modifiers": [], "additional_components": [ "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "species_374146", "Q8WS79", "FBgn0035849", "FBgn0261617", "M9MS40", "FBgn0261617", "species_374146", "Q8WS79", "FBgn0035849", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223" ] }, "reaction_10496075": { "compartment": "compartment_7660", "id": "reaction_10496075", "reactome": "R-DME-9009526", "name": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496071", "species_10447247" ], "products": [ "species_10496073" ], "modifiers": [], "additional_components": [ "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "FBgn0037770", "Q9VH48", "FBgn0037770", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10496077": { "compartment": "compartment_7660", "id": "reaction_10496077", "reactome": "R-DME-9009533", "name": "TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431317", "species_10431112", "species_10496069" ], "products": [ "species_10496071" ], "modifiers": [], "additional_components": [ "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10496079": { "compartment": "compartment_7660", "id": "reaction_10496079", "reactome": "R-DME-9009536", "name": "DDX5 binds ESR1:estrogen:TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429510", "species_10496067" ], "products": [ "species_10496069" ], "modifiers": [], "additional_components": [ "FBgn0035720", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720" ] }, "reaction_10496081": { "compartment": "compartment_7660", "id": "reaction_10496081", "reactome": "R-DME-9009541", "name": "ESR1 binds to TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495863", "species_10496065" ], "products": [ "species_10496067" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974" ] }, "reaction_10496945": { "compartment": "compartment_7660", "id": "reaction_10496945", "reactome": "R-DME-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496941", "species_10496937" ], "products": [ "species_10496943" ], "modifiers": [], "additional_components": [ "Q9VH48", "FBgn0037770", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VGW7", "FBgn0037834", "M9MS40", "FBgn0261617", "M9ND53", "FBgn0041092", "Q960X4", "FBgn0026080", "Q9VTZ1", "FBgn0020388", "M9MS40", "FBgn0261617", "M9ND53", "FBgn0041092", "Q960X4", "FBgn0026080", "Q9VTZ1", "FBgn0020388", "Q9VH48", "FBgn0037770", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VGW7", "FBgn0037834" ] }, "reaction_10496947": { "compartment": "compartment_7660", "id": "reaction_10496947", "reactome": "R-DME-9023861", "name": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467587", "species_10496071" ], "products": [ "species_10496939" ], "modifiers": [], "additional_components": [ "FBgn0037834", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VGW7", "FBgn0037834" ] }, "reaction_10496213": { "compartment": "compartment_7660", "id": "reaction_10496213", "reactome": "R-DME-9012315", "name": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496205", "species_10496209" ], "products": [ "species_10496211" ], "modifiers": [], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855" ] }, "reaction_10496951": { "compartment": "compartment_7660", "id": "reaction_10496951", "reactome": "R-DME-9023884", "name": "NCOA1 recruits EP300 to TGFA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458126", "species_10495873" ], "products": [ "species_10496949" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9ND53", "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9MS40", "FBgn0261617" ] }, "reaction_10491863": { "compartment": "compartment_7660", "id": "reaction_10491863", "reactome": "R-DME-8931981", "name": "RUNX1 binds ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458587", "species_10489794" ], "products": [ "species_10491861" ], "modifiers": [], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10496218": { "compartment": "compartment_7660", "id": "reaction_10496218", "reactome": "R-DME-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10496211" ], "products": [ "species_113582", "species_10496215" ], "modifiers": [ [ "species_10496211", "catalyst" ] ], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855" ] }, "reaction_10495871": { "compartment": "compartment_7660", "id": "reaction_10495871", "reactome": "R-DME-9008258", "name": "NCOA3 binds ESR1:estrogen:TFGA gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476674", "species_10495867" ], "products": [ "species_10495869" ], "modifiers": [], "additional_components": [ "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092" ] }, "reaction_10496898": { "compartment": "compartment_876", "id": "reaction_10496898", "reactome": "R-DME-9021600", "name": "G-proteins dissociate from plasma-membrane estrogen receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496896" ], "products": [ "species_10465520", "species_10434579", "species_10437767" ], "modifiers": [], "additional_components": [ "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P20353", "FBgn0001104" ] }, "reaction_10496900": { "compartment": "compartment_876", "id": "reaction_10496900", "reactome": "R-DME-9021601", "name": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465520", "species_10445744" ], "products": [ "species_10496896" ], "modifiers": [], "additional_components": [ "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146" ] }, "reaction_10496903": { "compartment": "compartment_876", "id": "reaction_10496903", "reactome": "R-DME-9021609", "name": "ESR-associated SRC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496890", "species_113592" ], "products": [ "species_10465522", "species_29370" ], "modifiers": [ [ "species_10496890", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146" ] }, "reaction_10496875": { "compartment": "compartment_20699", "id": "reaction_10496875", "reactome": "R-DME-9021072", "name": "ZDHHC7, ZDHHC21 palmitoylate ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_10496865" ], "products": [ "species_10471012", "species_10496857", "species_76194" ], "modifiers": [ [ "species_10496872", "catalyst" ] ], "additional_components": [ "Q8WS79", "FBgn0035849", "Q8IQW5", "FBgn0031037", "Q8IQW5", "FBgn0031037", "FBgn0035849", "Q9I7L7", "FBgn0042133", "Q9VBM6", "FBgn0039368", "Q9W251", "FBgn0034729", "Q8IQN9", "FBgn0036670", "Q9VBM5", "FBgn0039369", "Q9VBM8", "FBgn0039366", "Q0IGS7", "FBgn0033815", "Q9VBM4", "FBgn0039370", "Q9VBM7", "FBgn0039367", "Q7K3T4", "FBgn0034057" ] }, "reaction_10497874": { "compartment": "compartment_876", "id": "reaction_10497874", "reactome": "R-DME-9634584", "name": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431840", "species_10497870", "species_10497757" ], "products": [ "species_10497872" ], "modifiers": [], "additional_components": [ "FBgn0015296", "P09208", "InR", "species_374146", "Q8WS79", "FBgn0035849", "species_374146", "Q8WS79", "FBgn0035849", "P09208", "InR", "Q9V3C8", "FBgn0015296" ] }, "reaction_10496888": { "compartment": "compartment_876", "id": "reaction_10496888", "reactome": "R-DME-9021170", "name": "Estrogen stimulates dimerization of plasma membrane estrogen receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496878", "species_374146" ], "products": [ "species_10496886" ], "modifiers": [], "additional_components": [ "FBgn0035849", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10497818": { "compartment": "compartment_70101", "id": "reaction_10497818", "reactome": "R-DME-9632182", "name": "PRMT1 methylates ESRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5279190", "species_10497809" ], "products": [ "species_10496878", "species_71285" ], "modifiers": [ [ "species_10497815", "catalyst" ], [ "species_374146", "catalyst" ] ], "additional_components": [ "FBgn0035849", "FBgn0035849", "FBgn0037834" ] }, "reaction_10497851": { "compartment": "compartment_876", "id": "reaction_10497851", "reactome": "R-DME-9633044", "name": "ESR binds STRN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496886", "species_10465518" ], "products": [ "species_10497013" ], "modifiers": [], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "FBgn0044323", "D3DML3", "FBgn0044323", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10496892": { "compartment": "compartment_876", "id": "reaction_10496892", "reactome": "R-DME-9021596", "name": "Membrane estrogen receptors bind SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465520", "species_10438881" ], "products": [ "species_10496890" ], "modifiers": [ [ "species_10437767", "catalyst" ], [ "species_10434579", "catalyst" ] ], "additional_components": [ "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "FBgn0262733", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10441093": { "compartment": "compartment_7660", "id": "reaction_10441093", "reactome": "R-DME-199298", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784" ] }, "reaction_10497837": { "compartment": "compartment_7660", "id": "reaction_10497837", "reactome": "R-DME-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497833" ], "products": [ "species_10497835" ], "modifiers": [ [ "species_10437629", "catalyst" ], [ "species_10440931", "catalyst" ] ], "additional_components": [ "FBgn0010316", "FBgn0010316", "FBgn0020497", "P40417", "FBgn0003256" ] }, "reaction_10497725": { "compartment": "compartment_7660", "id": "reaction_10497725", "reactome": "R-DME-9624526", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441099" ], "products": [ "species_113582", "species_10441113" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10497727": { "compartment": "compartment_7660", "id": "reaction_10497727", "reactome": "R-DME-9624527", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441113" ], "products": [ "species_10497563" ], "modifiers": [], "additional_components": [] }, "reaction_10497759": { "compartment": "compartment_876", "id": "reaction_10497759", "reactome": "R-DME-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10446693", "catalyst" ], [ "species_10497757", "catalyst" ] ], "additional_components": [ "FBgn0030300", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10497042": { "compartment": "compartment_7660", "id": "reaction_10497042", "reactome": "R-DME-9029551", "name": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497000", "species_10440440" ], "products": [ "species_10497040" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "FBgn0041092", "M9ND53", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633" ] }, "reaction_10496998": { "compartment": "compartment_7660", "id": "reaction_10496998", "reactome": "R-DME-9024326", "name": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024383", "species_10496994" ], "products": [ "species_10496996" ], "modifiers": [], "additional_components": [ "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122" ] }, "reaction_10497046": { "compartment": "compartment_7660", "id": "reaction_10497046", "reactome": "R-DME-9029561", "name": "NCOA1 recruits EP300 to the ABCA1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458126", "species_10497040" ], "products": [ "species_10497044" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9ND53", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "M9ND53", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "M9MS40", "FBgn0261617" ] }, "reaction_10497002": { "compartment": "compartment_7660", "id": "reaction_10497002", "reactome": "R-DME-9024334", "name": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496996" ], "products": [ "species_10496990", "species_10497000" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633" ] }, "reaction_10497054": { "compartment": "compartment_7660", "id": "reaction_10497054", "reactome": "R-DME-9029580", "name": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497050", "species_10440440" ], "products": [ "species_10497052" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "M9ND53", "FBgn0041092" ] }, "reaction_10474430": { "compartment": "compartment_70101", "id": "reaction_10474430", "reactome": "R-DME-5634104", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471595" ], "products": [ "species_10471616" ], "modifiers": [], "additional_components": [ "species_5334816", "Q8INK3", "FBgn0037913", "Q8INK3", "FBgn0037913", "species_5334816" ] }, "reaction_10471597": { "compartment": "compartment_70101", "id": "reaction_10471597", "reactome": "R-DME-5334827", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471593", "species_5334816" ], "products": [ "species_10471595" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_5334816", "Q8INK3", "FBgn0037913" ] }, "reaction_10442349": { "compartment": "compartment_5460", "id": "reaction_10442349", "reactome": "R-DME-203946", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428865", "species_113593" ], "products": [ "species_113581", "species_10442333" ], "modifiers": [ [ "species_10442338", "catalyst" ], [ "species_29362", "catalyst" ], [ "species_113559", "catalyst" ], [ "species_10441275", "catalyst" ], [ "species_113557", "inhibitor" ], [ "species_10442347", "inhibitor" ] ], "additional_components": [ "Q9VM14", "FBgn0283658", "species_113596", "Q9VVL7", "FBgn0036762", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "Q9VM14", "FBgn0283658", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "species_113596", "Q9VVL7", "FBgn0036762", "FBgn0017558", "species_5334816", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P91622", "FBgn0017558" ] }, "reaction_10441277": { "compartment": "compartment_70101", "id": "reaction_10441277", "reactome": "R-DME-200406", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549207", "species_200993" ], "products": [ "species_201034", "species_76194" ], "modifiers": [ [ "species_10441263", "catalyst" ], [ "species_10441275", "catalyst" ], [ "species_29508", "inhibitor" ] ], "additional_components": [ "FBgn0261862", "species_5334816", "P20153", "FBgn0003964", "P13055", "FBgn0000568" ] }, "reaction_10474428": { "compartment": "compartment_7660", "id": "reaction_10474428", "reactome": "R-DME-5634103", "name": "SUMO-CRABP2 dissociates from atRA:RAR:RXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471618" ], "products": [ "species_10474426", "species_10471614" ], "modifiers": [], "additional_components": [ "P13055", "FBgn0000568", "P20153", "FBgn0003964", "Q8INK3", "FBgn0037913", "species_5334816", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "species_5334816", "FBgn0037913" ] }, "reaction_10471620": { "compartment": "compartment_7660", "id": "reaction_10471620", "reactome": "R-DME-5334854", "name": "RAR:RXR binds SUMO-CRABP2:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471616", "species_10471612" ], "products": [ "species_10471618" ], "modifiers": [], "additional_components": [ "Q8INK3", "FBgn0037913", "species_5334816", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "Q8INK3", "FBgn0037913", "species_5334816" ] }, "reaction_10473631": { "compartment": "compartment_70101", "id": "reaction_10473631", "reactome": "R-DME-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471971", "species_5334816" ], "products": [ "species_10471973" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_5334816", "Q8INK3", "FBgn0037913" ] }, "reaction_10472006": { "compartment": "compartment_70101", "id": "reaction_10472006", "reactome": "R-DME-5362721", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30927", "species_29360" ], "products": [ "species_70106", "species_32737", "species_73473" ], "modifiers": [ [ "species_10465841", "catalyst" ] ], "additional_components": [ "FBgn0000056" ] }, "reaction_10472004": { "compartment": "compartment_70101", "id": "reaction_10472004", "reactome": "R-DME-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10472001", "catalyst" ] ], "additional_components": [ "P46415", "FBgn0011768", "species_1562550" ] }, "reaction_10472051": { "compartment": "compartment_70101", "id": "reaction_10472051", "reactome": "R-DME-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10472048", "catalyst" ] ], "additional_components": [ "Q9VE80", "FBgn0038610", "Q8SZ46", "FBgn0286852", "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043", "Q9VRJ4", "FBgn0035588" ] }, "reaction_10473201": { "compartment": "compartment_70101", "id": "reaction_10473201", "reactome": "R-DME-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10471968": { "compartment": "compartment_70101", "id": "reaction_10471968", "reactome": "R-DME-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10471965", "catalyst" ] ], "additional_components": [ "Q9VIG6", "FBgn0032910", "Q9VCR9", "FBgn0039043", "Q9VKB8", "FBgn0032405", "Q9W3K9", "FBgn0029994", "Q9VCS2", "FBgn0039040", "Q9VR28", "FBgn0031630", "P91615", "FBgn0000056" ] }, "reaction_10436933": { "compartment": "compartment_70101", "id": "reaction_10436933", "reactome": "R-DME-165162", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436925" ], "products": [ "species_10436930", "species_29370" ], "modifiers": [ [ "species_10433712", "catalyst" ] ], "additional_components": [ "FBgn0005198", "FBgn0005198", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10436948": { "compartment": "compartment_70101", "id": "reaction_10436948", "reactome": "R-DME-165182", "name": "Phosphorylation of complexed TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436942" ], "products": [ "species_10436946", "species_29370" ], "modifiers": [ [ "species_10433712", "catalyst" ] ], "additional_components": [ "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10436958": { "compartment": "compartment_17938", "id": "reaction_10436958", "reactome": "R-DME-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10436954" ], "products": [ "species_29420", "species_10436956" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29420", "Q9VND8", "Rheb", "species_29438" ] }, "reaction_10445901": { "compartment": "compartment_70101", "id": "reaction_10445901", "reactome": "R-DME-380949", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10441308" ], "products": [ "species_29372", "species_10441300" ], "modifiers": [ [ "species_10445898", "catalyst" ] ], "additional_components": [ "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VBF9", "FBgn0039421", "Q961C5", "FBgn0086361" ] }, "reaction_10450613": { "compartment": "compartment_876", "id": "reaction_10450613", "reactome": "R-DME-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040", "species_113592" ], "products": [ "species_29370", "species_10437109" ], "modifiers": [ [ "species_10445887", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10445892": { "compartment": "compartment_70101", "id": "reaction_10445892", "reactome": "R-DME-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441308", "species_76577" ], "products": [ "species_10445887" ], "modifiers": [], "additional_components": [ "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10445890": { "compartment": "compartment_70101", "id": "reaction_10445890", "reactome": "R-DME-380927", "name": "p-AMPK phosphorylates TSC1:TSC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436942" ], "products": [ "species_29370", "species_10445885" ], "modifiers": [ [ "species_10445887", "catalyst" ] ], "additional_components": [ "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10445906": { "compartment": "compartment_70101", "id": "reaction_10445906", "reactome": "R-DME-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040" ], "products": [ "species_29372", "species_10445903" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10445885", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317" ] }, "reaction_10474811": { "compartment": "compartment_70101", "id": "reaction_10474811", "reactome": "R-DME-5653974", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437032", "species_10437004" ], "products": [ "species_10437034" ], "modifiers": [], "additional_components": [ "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10475738": { "compartment": "compartment_17938", "id": "reaction_10475738", "reactome": "R-DME-5672843", "name": "AKT1S1 (PRAS40) binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040", "species_10437061" ], "products": [ "species_10437063" ], "modifiers": [], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "FBgn0267824", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10498482": { "compartment": "compartment_70101", "id": "reaction_10498482", "reactome": "R-DME-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678687", "species_10437068" ], "products": [ "species_10437070" ], "modifiers": [], "additional_components": [ "FBgn0013954", "P48375", "FBgn0013954" ] }, "reaction_10437111": { "compartment": "compartment_17938", "id": "reaction_10437111", "reactome": "R-DME-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437089", "species_113592" ], "products": [ "species_29370", "species_10437099" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10437059", "catalyst" ], [ "species_10437070", "inhibitor" ], [ "species_10437109", "inhibitor" ] ], "additional_components": [ "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472", "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P48375", "FBgn0013954", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691" ] }, "reaction_10437077": { "compartment": "compartment_70101", "id": "reaction_10437077", "reactome": "R-DME-165708", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437048" ], "products": [ "species_10430485", "species_10437046" ], "modifiers": [], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709" ] }, "reaction_10437122": { "compartment": "compartment_70101", "id": "reaction_10437122", "reactome": "R-DME-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430332" ], "products": [ "species_29370", "species_10437119" ], "modifiers": [ [ "species_10437099", "catalyst" ] ], "additional_components": [ "FBgn0261592", "FBgn0261592", "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472" ] }, "reaction_10437136": { "compartment": "compartment_70101", "id": "reaction_10437136", "reactome": "R-DME-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430497", "species_113592" ], "products": [ "species_29370", "species_10437134" ], "modifiers": [ [ "species_10437099", "catalyst" ] ], "additional_components": [ "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472" ] }, "reaction_10437072": { "compartment": "compartment_17938", "id": "reaction_10437072", "reactome": "R-DME-165692", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430525" ], "products": [ "species_29370", "species_10437048" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10437059", "catalyst" ], [ "species_10437063", "inhibitor" ], [ "species_10437070", "inhibitor" ] ], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P48375", "FBgn0013954" ] }, "reaction_10474809": { "compartment": "compartment_17938", "id": "reaction_10474809", "reactome": "R-DME-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437036", "species_10436975" ], "products": [ "species_10437038" ], "modifiers": [], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10475736": { "compartment": "compartment_17938", "id": "reaction_10475736", "reactome": "R-DME-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437059", "species_113592" ], "products": [ "species_29370", "species_10475733" ], "modifiers": [ [ "species_10437059", "catalyst" ] ], "additional_components": [ "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10474807": { "compartment": "compartment_70101", "id": "reaction_10474807", "reactome": "R-DME-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437030", "species_10437017" ], "products": [ "species_10437032" ], "modifiers": [], "additional_components": [ "species_29420", "Q7K519", "FBgn0033272", "Q9VHJ4", "FBgn0037647", "species_29438", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10474805": { "compartment": "compartment_17938", "id": "reaction_10474805", "reactome": "R-DME-5653936", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436992", "species_10436997", "species_10436982", "species_10437002", "species_10436987" ], "products": [ "species_10437004" ], "modifiers": [], "additional_components": [ "FBgn0032642", "FBgn0035469", "FBgn0036932", "FBgn0026090", "FBgn0034350", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642" ] }, "reaction_10494954": { "compartment": "compartment_70101", "id": "reaction_10494954", "reactome": "R-DME-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10437036", "catalyst" ] ], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10437042": { "compartment": "compartment_70101", "id": "reaction_10437042", "reactome": "R-DME-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436956", "species_10437038" ], "products": [ "species_10437040" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29438", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10475729": { "compartment": "compartment_17938", "id": "reaction_10475729", "reactome": "R-DME-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437057", "species_10432008" ], "products": [ "species_10437059" ], "modifiers": [], "additional_components": [ "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10445389": { "compartment": "compartment_17938", "id": "reaction_10445389", "reactome": "R-DME-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437063" ], "products": [ "species_10437057", "species_29370" ], "modifiers": [ [ "species_10441842", "catalyst" ] ], "additional_components": [ "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10438766": { "compartment": "compartment_17963", "id": "reaction_10438766", "reactome": "R-DME-177107", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437824" ], "products": [ "species_10437860" ], "modifiers": [], "additional_components": [ "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10437884": { "compartment": "compartment_17941", "id": "reaction_10437884", "reactome": "R-DME-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437880" ], "products": [ "species_10437882", "species_10437838" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "FBgn0025800" ] }, "reaction_10437893": { "compartment": "compartment_171062", "id": "reaction_10437893", "reactome": "R-DME-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437890", "species_113592" ], "products": [ "species_29370", "species_10437880" ], "modifiers": [ [ "species_10437890", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300" ] }, "reaction_10437826": { "compartment": "compartment_20699", "id": "reaction_10437826", "reactome": "R-DME-170844", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437814" ], "products": [ "species_10437824" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "FBgn0004509" ] }, "reaction_10437967": { "compartment": "compartment_70101", "id": "reaction_10437967", "reactome": "R-DME-173542", "name": "SMURF2 ubiquitinates SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437962", "species_10426987" ], "products": [ "species_10437960", "species_10437964" ], "modifiers": [ [ "species_10437962", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "Q9V853", "FBgn0029006", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0029006", "O96660", "FBgn0025800", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O96660", "FBgn0025800", "Q9V853", "FBgn0029006" ] }, "reaction_10465227": { "compartment": "compartment_70101", "id": "reaction_10465227", "reactome": "R-DME-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437964" ], "products": [], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10465225": { "compartment": "compartment_70101", "id": "reaction_10465225", "reactome": "R-DME-2176445", "name": "SMURF2 binds SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437960", "species_10437886" ], "products": [ "species_10437962" ], "modifiers": [], "additional_components": [ "FBgn0029006", "FBgn0025800", "O96660", "FBgn0025800", "Q9V853", "FBgn0029006" ] }, "reaction_10465352": { "compartment": "compartment_70101", "id": "reaction_10465352", "reactome": "R-DME-2187382", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465345" ], "products": [], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O96660", "FBgn0025800" ] }, "reaction_10465350": { "compartment": "compartment_70101", "id": "reaction_10465350", "reactome": "R-DME-2187375", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437888", "species_10456460" ], "products": [ "species_10465343" ], "modifiers": [], "additional_components": [ "FBgn0025800", "FBgn0027052", "Q9XYW6", "FBgn0027052", "O96660", "FBgn0025800" ] }, "reaction_10465365": { "compartment": "compartment_70101", "id": "reaction_10465365", "reactome": "R-DME-2187405", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465358", "species_10437838" ], "products": [ "species_10465360" ], "modifiers": [], "additional_components": [ "FBgn0030735", "FBgn0025800", "O96660", "FBgn0025800", "Q7YU03", "FBgn0030735" ] }, "reaction_10465348": { "compartment": "compartment_70101", "id": "reaction_10465348", "reactome": "R-DME-2187368", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10465343" ], "products": [ "species_10465345", "species_10456460" ], "modifiers": [ [ "species_10465343", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XYW6", "FBgn0027052", "O96660", "FBgn0025800", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O96660", "FBgn0025800", "FBgn0027052", "Q9XYW6", "FBgn0027052", "O96660", "FBgn0025800" ] }, "reaction_10465363": { "compartment": "compartment_70101", "id": "reaction_10465363", "reactome": "R-DME-2187401", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465360", "species_29356" ], "products": [ "species_29372", "species_10465358", "species_10437886" ], "modifiers": [ [ "species_10465360", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "Q7YU03", "FBgn0030735", "FBgn0030735", "FBgn0025800", "O96660", "FBgn0025800", "Q7YU03", "FBgn0030735" ] }, "reaction_10465037": { "compartment": "compartment_204883", "id": "reaction_10465037", "reactome": "R-DME-2160931", "name": "Disassembly of tight junctions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465035" ], "products": [], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V853", "FBgn0029006", "M9PBE1", "FBgn0032796", "P48148", "Rho1", "A1Z9X0", "FBgn0261854", "Q0KHR3", "FBgn0000163", "O97111", "FBgn0026192", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300" ] }, "reaction_10454143": { "compartment": "compartment_70101", "id": "reaction_10454143", "reactome": "R-DME-870479", "name": "USP9X (FAM) binds to ubiquitinated SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454130", "species_10454139" ], "products": [ "species_10454132" ], "modifiers": [], "additional_components": [ "FBgn0005632", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P55824", "FBgn0005632" ] }, "reaction_10454141": { "compartment": "compartment_7660", "id": "reaction_10454141", "reactome": "R-DME-870477", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454137" ], "products": [ "species_10454139" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O62609", "FBgn0011655", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655" ] }, "reaction_10465341": { "compartment": "compartment_7660", "id": "reaction_10465341", "reactome": "R-DME-2187330", "name": "PARP1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437946", "species_10465325" ], "products": [ "species_10465327" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0010247", "P35875", "FBgn0010247", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465339": { "compartment": "compartment_7660", "id": "reaction_10465339", "reactome": "R-DME-2187325", "name": "PARP1 ADP-ribosylates SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10465327" ], "products": [ "species_427497", "species_10465336", "species_10465325" ], "modifiers": [ [ "species_10465327", "catalyst" ] ], "additional_components": [ "P35875", "FBgn0010247", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "FBgn0010247", "P35875", "FBgn0010247", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10437976": { "compartment": "compartment_7660", "id": "reaction_10437976", "reactome": "R-DME-173545", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437946" ], "products": [], "modifiers": [ [ "species_10437973", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q9Y165", "FBgn0027609", "P25867", "eff" ] }, "reaction_10454135": { "compartment": "compartment_70101", "id": "reaction_10454135", "reactome": "R-DME-870437", "name": "USP9X (FAM) deubiquitinates SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10454132" ], "products": [ "species_10454130", "species_10437831", "species_10426987" ], "modifiers": [ [ "species_10454132", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P55824", "FBgn0005632", "FBgn0005632", "FBgn0011655", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P55824", "FBgn0005632" ] }, "reaction_10465265": { "compartment": "compartment_7660", "id": "reaction_10465265", "reactome": "R-DME-2179276", "name": "SMURF2 monoubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10465258" ], "products": [ "species_10437940", "species_10465256", "species_10465262" ], "modifiers": [ [ "species_10465258", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9V853", "FBgn0029006", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0011655", "FBgn0029006", "O96660", "FBgn0025800", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9V853", "FBgn0029006", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465294": { "compartment": "compartment_7660", "id": "reaction_10465294", "reactome": "R-DME-2186767", "name": "Degradation of ubiquitinated SKI/SKIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465292" ], "products": [], "modifiers": [], "additional_components": [ "Q00G30", "FBgn0085450", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11" ] }, "reaction_10442669": { "compartment": "compartment_7660", "id": "reaction_10442669", "reactome": "R-DME-209055", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10442662" ], "products": [ "species_113550", "species_10442660", "species_10437940", "species_10442664" ], "modifiers": [ [ "species_10442662", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421", "FBgn0011655", "FBgn0025800", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421" ] }, "reaction_10465260": { "compartment": "compartment_7660", "id": "reaction_10465260", "reactome": "R-DME-2179274", "name": "SMURF2 binds SMAD3 phosphorylated in the linker region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465235", "species_10465256" ], "products": [ "species_10465258" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0029006", "Q9V853", "FBgn0029006", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465356": { "compartment": "compartment_70101", "id": "reaction_10465356", "reactome": "R-DME-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442664" ], "products": [ "species_10437886" ], "modifiers": [], "additional_components": [ "FBgn0025800", "FBgn0025800" ] }, "reaction_10465354": { "compartment": "compartment_7660", "id": "reaction_10465354", "reactome": "R-DME-2187388", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442660", "species_10437946" ], "products": [ "species_10442662" ], "modifiers": [], "additional_components": [ "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421" ] }, "reaction_10465254": { "compartment": "compartment_7660", "id": "reaction_10465254", "reactome": "R-DME-2176503", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465250" ], "products": [], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465252": { "compartment": "compartment_7660", "id": "reaction_10465252", "reactome": "R-DME-2176502", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10465246" ], "products": [ "species_10465250", "species_10465244" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VVI3", "FBgn0259174", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0259174" ] }, "reaction_10465248": { "compartment": "compartment_7660", "id": "reaction_10465248", "reactome": "R-DME-2176491", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465235", "species_10465244" ], "products": [ "species_10465246" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0259174", "Q9VVI3", "FBgn0259174", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10464907": { "compartment": "compartment_7660", "id": "reaction_10464907", "reactome": "R-DME-2127257", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458009", "species_10437946" ], "products": [ "species_10464905" ], "modifiers": [], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10465242": { "compartment": "compartment_7660", "id": "reaction_10465242", "reactome": "R-DME-2176475", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437946" ], "products": [ "species_113582", "species_10465235" ], "modifiers": [ [ "species_10465239", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "P25008", "FBgn0004597", "Q9VT57", "FBgn0015618", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10465290": { "compartment": "compartment_7660", "id": "reaction_10465290", "reactome": "R-DME-2186643", "name": "MEN1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465286", "species_10437946" ], "products": [ "species_10465288" ], "modifiers": [], "additional_components": [ "FBgn0031885", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q9VM47", "FBgn0031885" ] }, "reaction_10464521": { "compartment": "compartment_70101", "id": "reaction_10464521", "reactome": "R-DME-2031355", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437844", "species_10464315" ], "products": [ "species_10464519" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q45VV3", "yki", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465320": { "compartment": "compartment_7660", "id": "reaction_10465320", "reactome": "R-DME-2187309", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465316", "species_10437946" ], "products": [ "species_10465318" ], "modifiers": [], "additional_components": [ "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364" ] }, "reaction_10471447": { "compartment": "compartment_13231", "id": "reaction_10471447", "reactome": "R-DME-5252001", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471443", "species_10429914" ], "products": [ "species_10471445" ], "modifiers": [], "additional_components": [ "Q9V3Q7", "FBgn0038690", "Q7KT77", "FBgn0053310", "Q24048", "FBgn0015777", "Q24046", "FBgn0015776", "M9PDX8", "FBgn0032946", "Q9VDY7", "FBgn0038691", "FBgn0004856", "P39736", "FBgn0004856", "Q9V3Q7", "FBgn0038690", "Q7KT77", "FBgn0053310", "Q24048", "FBgn0015777", "Q24046", "FBgn0015776", "M9PDX8", "FBgn0032946", "Q9VDY7", "FBgn0038691" ] }, "reaction_10464867": { "compartment": "compartment_70101", "id": "reaction_10464867", "reactome": "R-DME-2106579", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464519" ], "products": [ "species_10464865" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q45VV3", "yki", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10441485": { "compartment": "compartment_70101", "id": "reaction_10441485", "reactome": "R-DME-201422", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441476", "species_10437831" ], "products": [ "species_10441483" ], "modifiers": [], "additional_components": [ "FBgn0011648", "FBgn0011655", "O62609", "FBgn0011655", "P42003", "FBgn0011648" ] }, "reaction_10441565": { "compartment": "compartment_13231", "id": "reaction_10441565", "reactome": "R-DME-201472", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441483" ], "products": [ "species_10441493" ], "modifiers": [], "additional_components": [ "O62609", "FBgn0011655", "P42003", "FBgn0011648", "P42003", "FBgn0011648", "O62609", "FBgn0011655" ] }, "reaction_10441563": { "compartment": "compartment_984", "id": "reaction_10441563", "reactome": "R-DME-201457", "name": "BMP2 binds to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441506", "species_10441524" ], "products": [ "species_10441526" ], "modifiers": [], "additional_components": [ "P07713", "FBgn0000490", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "P07713", "FBgn0000490" ] }, "reaction_10441499": { "compartment": "compartment_7660", "id": "reaction_10441499", "reactome": "R-DME-201425", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441493" ], "products": [], "modifiers": [ [ "species_10437973", "catalyst" ] ], "additional_components": [ "P42003", "FBgn0011648", "O62609", "FBgn0011655", "Q9Y165", "FBgn0027609", "P25867", "eff" ] }, "reaction_10441561": { "compartment": "compartment_17941", "id": "reaction_10441561", "reactome": "R-DME-201453", "name": "Phospho-R-Smad1/5/8 dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441557" ], "products": [ "species_10441476", "species_10441559" ], "modifiers": [], "additional_components": [ "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716" ] }, "reaction_10441497": { "compartment": "compartment_7660", "id": "reaction_10441497", "reactome": "R-DME-201423", "name": "SKI complexes with the Smad complex, suppressing BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441493", "species_10437951" ], "products": [ "species_10441495" ], "modifiers": [], "additional_components": [ "P42003", "FBgn0011648", "O62609", "FBgn0011655", "FBgn0085450", "Q00G30", "FBgn0085450", "P42003", "FBgn0011648", "O62609", "FBgn0011655" ] }, "reaction_10441671": { "compartment": "compartment_70101", "id": "reaction_10441671", "reactome": "R-DME-201648", "name": "An anchoring protein, Endofin, recruits R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441555", "species_10441539", "species_10441544" ], "products": [ "species_10441567" ], "modifiers": [], "additional_components": [ "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "FBgn0011648", "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716" ] }, "reaction_10441958": { "compartment": "compartment_876", "id": "reaction_10441958", "reactome": "R-DME-202604", "name": "Formation of a heteromeric BMP receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441522", "species_10441515" ], "products": [ "species_10441524" ], "modifiers": [], "additional_components": [ "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179" ] }, "reaction_10441542": { "compartment": "compartment_70101", "id": "reaction_10441542", "reactome": "R-DME-201443", "name": "Type II receptor phosphorylates type I receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441526" ], "products": [ "species_10441539", "species_29370" ], "modifiers": [ [ "species_10441526", "catalyst" ] ], "additional_components": [ "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "P07713", "FBgn0000490", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "P07713", "FBgn0000490" ] }, "reaction_10441570": { "compartment": "compartment_876", "id": "reaction_10441570", "reactome": "R-DME-201476", "name": "Activated type I receptor phosphorylates R-Smad1/5/8 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441567" ], "products": [ "species_29370", "species_10441557" ], "modifiers": [ [ "species_10441567", "catalyst" ] ], "additional_components": [ "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716" ] }, "reaction_10441553": { "compartment": "compartment_70101", "id": "reaction_10441553", "reactome": "R-DME-201445", "name": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441544" ], "products": [], "modifiers": [ [ "species_10437960", "catalyst" ] ], "additional_components": [ "FBgn0011648", "FBgn0029006" ] }, "reaction_10457846": { "compartment": "compartment_876", "id": "reaction_10457846", "reactome": "R-DME-1181149", "name": "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10457836" ], "products": [ "species_10457843", "species_29370" ], "modifiers": [ [ "species_10457836", "catalyst" ] ], "additional_components": [ "O61643", "FBgn0024913", "A1Z7L8", "FBgn0011300", "O61643", "FBgn0024913", "A1Z7L8", "FBgn0011300", "O61643", "FBgn0024913", "A1Z7L8", "FBgn0011300" ] }, "reaction_10459937": { "compartment": "compartment_70101", "id": "reaction_10459937", "reactome": "R-DME-1549526", "name": "Phosphorylation of SMAD2/3 by Activin:Activin Receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437886" ], "products": [ "species_29370", "species_10437838" ], "modifiers": [ [ "species_10459934", "catalyst" ] ], "additional_components": [ "FBgn0025800", "FBgn0025800", "A1Z7L8", "FBgn0011300", "O61643", "FBgn0024913" ] }, "reaction_10493361": { "compartment": "compartment_7660", "id": "reaction_10493361", "reactome": "R-DME-8944349", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493357", "species_10468252" ], "products": [ "species_10493359" ], "modifiers": [], "additional_components": [ "Q8IMA8", "FBgn0085432", "P16371", "GRO", "P16371", "GRO", "Q8IMA8", "FBgn0085432" ] }, "reaction_10471580": { "compartment": "compartment_7660", "id": "reaction_10471580", "reactome": "R-DME-5334050", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468226", "species_10467421" ], "products": [ "species_10471578" ], "modifiers": [], "additional_components": [ "FBgn0085432", "FBgn0020496", "O46036", "FBgn0020496", "Q8IMA8", "FBgn0085432" ] }, "reaction_10470019": { "compartment": "compartment_7660", "id": "reaction_10470019", "reactome": "R-DME-4641229", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468236" ], "products": [ "species_10468252" ], "modifiers": [], "additional_components": [ "P16371", "GRO" ] }, "reaction_10440586": { "compartment": "compartment_70101", "id": "reaction_10440586", "reactome": "R-DME-195280", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440579" ], "products": [ "species_10440579" ], "modifiers": [], "additional_components": [ "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn" ] }, "reaction_10464922": { "compartment": "compartment_70101", "id": "reaction_10464922", "reactome": "R-DME-2130286", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464912", "species_10426987" ], "products": [ "species_10464916" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn" ] }, "reaction_10440607": { "compartment": "compartment_70101", "id": "reaction_10440607", "reactome": "R-DME-195300", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440594", "species_113592" ], "products": [ "species_29370", "species_10440570" ], "modifiers": [ [ "species_10440594", "catalyst" ] ], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_10440604": { "compartment": "compartment_70101", "id": "reaction_10440604", "reactome": "R-DME-195287", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440601" ], "products": [ "species_29370", "species_10440590" ], "modifiers": [ [ "species_10440601", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10440616": { "compartment": "compartment_70101", "id": "reaction_10440616", "reactome": "R-DME-195318", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440611", "species_113592" ], "products": [ "species_29370", "species_10440601" ], "modifiers": [ [ "species_10440611", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10440597": { "compartment": "compartment_70101", "id": "reaction_10440597", "reactome": "R-DME-195283", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440590" ], "products": [ "species_10440594", "species_29370" ], "modifiers": [ [ "species_10440590", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10440584": { "compartment": "compartment_70101", "id": "reaction_10440584", "reactome": "R-DME-195275", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440570" ], "products": [ "species_10440579", "species_29370" ], "modifiers": [ [ "species_10440570", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10464920": { "compartment": "compartment_70101", "id": "reaction_10464920", "reactome": "R-DME-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464916" ], "products": [ "species_10442677", "species_10464918", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10471110": { "compartment": "compartment_70101", "id": "reaction_10471110", "reactome": "R-DME-5229343", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441755" ], "products": [ "species_10440560", "species_29370" ], "modifiers": [ [ "species_10441755", "catalyst" ] ], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650" ] }, "reaction_10440613": { "compartment": "compartment_70101", "id": "reaction_10440613", "reactome": "R-DME-195304", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440560", "species_10440609" ], "products": [ "species_10440611" ], "modifiers": [], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10464914": { "compartment": "compartment_70101", "id": "reaction_10464914", "reactome": "R-DME-2130279", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440579", "species_10442677" ], "products": [ "species_10464912" ], "modifiers": [], "additional_components": [ "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn" ] }, "reaction_10469710": { "compartment": "compartment_70101", "id": "reaction_10469710", "reactome": "R-DME-4332363", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469702" ], "products": [ "species_10469697", "species_29370" ], "modifiers": [ [ "species_10469702", "catalyst" ] ], "additional_components": [ "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10469834": { "compartment": "compartment_70101", "id": "reaction_10469834", "reactome": "R-DME-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469828" ], "products": [ "species_10469832" ], "modifiers": [], "additional_components": [ "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_74016", "Q24214", "FBgn0015614", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_1222611", "species_1562550" ] }, "reaction_10469706": { "compartment": "compartment_70101", "id": "reaction_10469706", "reactome": "R-DME-4332359", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10449351" ], "products": [ "species_10469702" ], "modifiers": [ [ "species_10469704", "inhibitor" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10469736": { "compartment": "compartment_7660", "id": "reaction_10469736", "reactome": "R-DME-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469730" ], "products": [ "species_10469734" ], "modifiers": [], "additional_components": [ "A0A4D6K823", "FBgn0011817", "A0A4D6K823", "FBgn0011817" ] }, "reaction_10469751": { "compartment": "compartment_7660", "id": "reaction_10469751", "reactome": "R-DME-4411383", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10469738" ], "products": [ "species_113582", "species_10469748" ], "modifiers": [ [ "species_10469734", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q8IMA8", "FBgn0085432", "P18824", "arm", "A0A4D6K823", "FBgn0011817" ] }, "reaction_10469558": { "compartment": "compartment_876", "id": "reaction_10469558", "reactome": "R-DME-3965447", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469553" ], "products": [ "species_10469538", "species_10434579", "species_10469543" ], "modifiers": [], "additional_components": [ "P16378", "FBgn0001122", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "FBgn0001122" ] }, "reaction_10446854": { "compartment": "compartment_70101", "id": "reaction_10446854", "reactome": "R-DME-398040", "name": "Gbeta:gamma activation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10434175" ], "products": [ "species_10446852" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "FBgn0004611", "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10469830": { "compartment": "compartment_70101", "id": "reaction_10469830", "reactome": "R-DME-4551451", "name": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10464038", "species_10464071" ], "products": [ "species_29372", "species_10469828" ], "modifiers": [ [ "species_10464071", "catalyst" ] ], "additional_components": [ "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614" ] }, "reaction_10469556": { "compartment": "compartment_876", "id": "reaction_10469556", "reactome": "R-DME-3965444", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10469549" ], "products": [ "species_10469553", "species_29420" ], "modifiers": [ [ "species_10469549", "catalyst" ] ], "additional_components": [ "P16378", "FBgn0001122", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16378", "FBgn0001122", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16378", "FBgn0001122", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343" ] }, "reaction_10466948": { "compartment": "compartment_70101", "id": "reaction_10466948", "reactome": "R-DME-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10464021", "species_74016" ], "products": [ "species_10464071" ], "modifiers": [], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614" ] }, "reaction_10469700": { "compartment": "compartment_70101", "id": "reaction_10469700", "reactome": "R-DME-4332358", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469697", "species_113592" ], "products": [ "species_10434387", "species_29370", "species_10469695" ], "modifiers": [ [ "species_10469697", "catalyst" ] ], "additional_components": [ "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10446865": { "compartment": "compartment_70101", "id": "reaction_10446865", "reactome": "R-DME-398193", "name": "PLC beta-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10446852", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10469087": { "compartment": "compartment_70101", "id": "reaction_10469087", "reactome": "R-DME-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441719", "species_10469083" ], "products": [ "species_10469085" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29438", "P51140", "phospho-dsh" ] }, "reaction_10469101": { "compartment": "compartment_876", "id": "reaction_10469101", "reactome": "R-DME-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441768", "species_10469097" ], "products": [ "species_10469099" ], "modifiers": [], "additional_components": [ "P09615", "WG", "Q9VFX1", "FBgn0038134", "P40589", "FBgn0010453", "P18537", "FZ", "P09615", "WG", "Q9VFX1", "FBgn0038134", "P40589", "FBgn0010453", "P18537", "FZ", "P51140", "phospho-dsh" ] }, "reaction_10470350": { "compartment": "compartment_876", "id": "reaction_10470350", "reactome": "R-DME-5138432", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470343" ], "products": [ "species_29370", "species_10470345" ], "modifiers": [ [ "species_10470347", "catalyst" ] ], "additional_components": [ "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343" ] }, "reaction_10470362": { "compartment": "compartment_876", "id": "reaction_10470362", "reactome": "R-DME-5138441", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441761", "species_10470339" ], "products": [ "species_10470343" ], "modifiers": [], "additional_components": [ "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh" ] }, "reaction_10470360": { "compartment": "compartment_876", "id": "reaction_10470360", "reactome": "R-DME-5138433", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470354", "species_10470345", "species_10447483" ], "products": [ "species_10470358" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319" ] }, "reaction_10470341": { "compartment": "compartment_876", "id": "reaction_10470341", "reactome": "R-DME-5099899", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469528", "species_10468078" ], "products": [ "species_10470339" ], "modifiers": [], "additional_components": [ "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "FBgn0010194", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343" ] }, "reaction_10470402": { "compartment": "compartment_20592", "id": "reaction_10470402", "reactome": "R-DME-5138459", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470358" ], "products": [ "species_10470400", "species_10447483" ], "modifiers": [], "additional_components": [ "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P29742", "FBgn0000319", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120" ] }, "reaction_10470415": { "compartment": "compartment_876", "id": "reaction_10470415", "reactome": "R-DME-5140741", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470411", "species_10468078" ], "products": [ "species_10470413" ], "modifiers": [], "additional_components": [ "Q9VVX3", "FZ2", "P18537", "FZ", "Q24488", "FBgn0010407", "FBgn0010194", "P28466", "FBgn0010194", "Q9VVX3", "FZ2", "P18537", "FZ", "Q24488", "FBgn0010407" ] }, "reaction_10470429": { "compartment": "compartment_20592", "id": "reaction_10470429", "reactome": "R-DME-5140747", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470413" ], "products": [ "species_10470427" ], "modifiers": [ [ "species_10470354", "catalyst" ] ], "additional_components": [ "P28466", "FBgn0010194", "Q9VVX3", "FZ2", "P18537", "FZ", "Q24488", "FBgn0010407", "P28466", "FBgn0010194", "Q24488", "FBgn0010407", "Q9VVX3", "FZ2", "P18537", "FZ", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319" ] }, "reaction_10468030": { "compartment": "compartment_20699", "id": "reaction_10468030", "reactome": "R-DME-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468016", "species_10467932" ], "products": [ "species_10468028" ], "modifiers": [], "additional_components": [ "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "FBgn0036141", "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902" ] }, "reaction_10468026": { "compartment": "compartment_171062", "id": "reaction_10468026", "reactome": "R-DME-3247839", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467923", "species_10467928", "species_10467918" ], "products": [ "species_10467930" ], "modifiers": [], "additional_components": [ "FBgn0036141", "FBgn0038065", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q9VG51", "FBgn0038065", "Q95ST2", "FBgn0036141" ] }, "reaction_10468088": { "compartment": "compartment_20699", "id": "reaction_10468088", "reactome": "R-DME-3247849", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467934" ], "products": [ "species_10467928", "species_10467932", "species_10467918" ], "modifiers": [], "additional_components": [ "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q95ST2", "FBgn0036141", "Q9VG51", "FBgn0038065", "FBgn0038065", "FBgn0036141", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411" ] }, "reaction_10468023": { "compartment": "compartment_17963", "id": "reaction_10468023", "reactome": "R-DME-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467992" ], "products": [ "species_10468016" ], "modifiers": [ [ "species_10468021", "catalyst" ] ], "additional_components": [ "P28465", "FBgn0004360", "P28466", "FBgn0010194", "Q9VM26", "FBgn0031902", "P09615", "WG", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "FBgn0264389" ] }, "reaction_10468086": { "compartment": "compartment_171062", "id": "reaction_10468086", "reactome": "R-DME-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468032" ], "products": [ "species_10467923" ], "modifiers": [], "additional_components": [ "FBgn0036141", "FBgn0036141" ] }, "reaction_10468084": { "compartment": "compartment_20699", "id": "reaction_10468084", "reactome": "R-DME-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468028" ], "products": [ "species_10468058" ], "modifiers": [], "additional_components": [ "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141" ] }, "reaction_10468898": { "compartment": "compartment_876", "id": "reaction_10468898", "reactome": "R-DME-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468058" ], "products": [ "species_10468866" ], "modifiers": [], "additional_components": [ "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141", "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902" ] }, "reaction_10468082": { "compartment": "compartment_984", "id": "reaction_10468082", "reactome": "R-DME-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468058" ], "products": [ "species_10468080", "species_10468032" ], "modifiers": [], "additional_components": [ "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141", "P09615", "WG", "Q9VM25", "FBgn0031903", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "Q9VFX1", "FBgn0038134", "P40589", "FBgn0010453", "FBgn0036141" ] }, "reaction_10468896": { "compartment": "compartment_383505", "id": "reaction_10468896", "reactome": "R-DME-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468866" ], "products": [ "species_10468894" ], "modifiers": [], "additional_components": [ "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141" ] }, "reaction_10467936": { "compartment": "compartment_20699", "id": "reaction_10467936", "reactome": "R-DME-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467930" ], "products": [ "species_10467934" ], "modifiers": [], "additional_components": [ "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q9VG51", "FBgn0038065", "Q95ST2", "FBgn0036141", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q95ST2", "FBgn0036141", "Q9VG51", "FBgn0038065" ] }, "reaction_10444271": { "compartment": "compartment_70101", "id": "reaction_10444271", "reactome": "R-DME-354060", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444262", "species_10444267", "species_179856" ], "products": [ "species_10444269" ], "modifiers": [], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "FBgn0261811", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438" ] }, "reaction_10449918": { "compartment": "compartment_876", "id": "reaction_10449918", "reactome": "R-DME-443910", "name": "SHC1 dissociates from integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449914" ], "products": [ "species_10444292", "species_10431830" ], "modifiers": [], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "FBgn0015296" ] }, "reaction_10449916": { "compartment": "compartment_876", "id": "reaction_10449916", "reactome": "R-DME-443905", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449253" ], "products": [ "species_10449914" ], "modifiers": [], "additional_components": [ "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733" ] }, "reaction_10455337": { "compartment": "compartment_70101", "id": "reaction_10455337", "reactome": "R-DME-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10444300" ], "products": [ "species_29420", "species_10444262" ], "modifiers": [ [ "species_10446030", "catalyst" ] ], "additional_components": [ "P08645", "FBgn0004636", "species_29420", "P08645", "FBgn0004636", "species_29438", "FBgn0085421" ] }, "reaction_10444296": { "compartment": "compartment_70101", "id": "reaction_10444296", "reactome": "R-DME-354097", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444276", "species_10444269" ], "products": [ "species_10444278" ], "modifiers": [], "additional_components": [ "FBgn0260442", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442" ] }, "reaction_10449255": { "compartment": "compartment_70101", "id": "reaction_10449255", "reactome": "R-DME-432096", "name": "Activated integrin alphaIIb beta3 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431840", "species_10444292" ], "products": [ "species_10449253" ], "modifiers": [], "additional_components": [ "FBgn0015296", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296" ] }, "reaction_10444294": { "compartment": "compartment_876", "id": "reaction_10444294", "reactome": "R-DME-354077", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444290", "species_10444278" ], "products": [ "species_10444292" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733" ] }, "reaction_10464527": { "compartment": "compartment_70101", "id": "reaction_10464527", "reactome": "R-DME-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544" ], "products": [ "species_10458548" ], "modifiers": [], "additional_components": [] }, "reaction_10464525": { "compartment": "compartment_70101", "id": "reaction_10464525", "reactome": "R-DME-2032768", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464315" ], "products": [ "species_10464523" ], "modifiers": [], "additional_components": [] }, "reaction_10464317": { "compartment": "compartment_70101", "id": "reaction_10464317", "reactome": "R-DME-2028661", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10464315" ], "products": [ "species_10464309", "species_29370" ], "modifiers": [ [ "species_10464286", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464300": { "compartment": "compartment_70101", "id": "reaction_10464300", "reactome": "R-DME-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464261", "species_10464269" ], "products": [ "species_10464271" ], "modifiers": [], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464298": { "compartment": "compartment_70101", "id": "reaction_10464298", "reactome": "R-DME-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544", "species_113592" ], "products": [ "species_29370", "species_10464295" ], "modifiers": [ [ "species_10464281", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464313": { "compartment": "compartment_70101", "id": "reaction_10464313", "reactome": "R-DME-2028651", "name": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432016", "species_10464309" ], "products": [ "species_10464311" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "Q45VV3", "yki", "P92177", "14-3-3epsilon" ] }, "reaction_10464568": { "compartment": "compartment_70101", "id": "reaction_10464568", "reactome": "R-DME-2038398", "name": "KIBRA (WWC1) binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464564", "species_10464261" ], "products": [ "species_10464566" ], "modifiers": [], "additional_components": [ "FBgn0262127", "Q9VA38", "WTS", "Q9VFG8", "FBgn0262127" ] }, "reaction_10464693": { "compartment": "compartment_70101", "id": "reaction_10464693", "reactome": "R-DME-2060328", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10464315" ], "products": [ "species_10464309", "species_29370" ], "modifiers": [ [ "species_10464281", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464773": { "compartment": "compartment_70101", "id": "reaction_10464773", "reactome": "R-DME-2066299", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441761", "species_10464309" ], "products": [ "species_10464771" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P51140", "phospho-dsh" ] }, "reaction_10464306": { "compartment": "compartment_70101", "id": "reaction_10464306", "reactome": "R-DME-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432010", "species_10464284" ], "products": [ "species_10464304" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "Q45VV3", "yki", "P29310", "14-3-3zeta" ] }, "reaction_10464289": { "compartment": "compartment_70101", "id": "reaction_10464289", "reactome": "R-DME-2028583", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544", "species_113592" ], "products": [ "species_29370", "species_10464284" ], "modifiers": [ [ "species_10464286", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10440828": { "compartment": "compartment_70101", "id": "reaction_10440828", "reactome": "R-DME-198609", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436925" ], "products": [ "species_29370", "species_10440825" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0005198", "FBgn0005198" ] }, "reaction_10441258": { "compartment": "compartment_70101", "id": "reaction_10441258", "reactome": "R-DME-200143", "name": "AKT phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437061", "species_113592" ], "products": [ "species_29370", "species_10441256" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0267824", "FBgn0267824" ] }, "reaction_10493525": { "compartment": "compartment_70101", "id": "reaction_10493525", "reactome": "R-DME-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10456731" ], "products": [ "species_29370", "species_10493523" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0029152", "FBgn0029152" ] }, "reaction_10440837": { "compartment": "compartment_70101", "id": "reaction_10440837", "reactome": "R-DME-198611", "name": "AKT phosphorylates IKKalpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440832", "species_113592" ], "products": [ "species_10440835", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [] }, "reaction_10440852": { "compartment": "compartment_70101", "id": "reaction_10440852", "reactome": "R-DME-198621", "name": "AKT phosphorylates caspase-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434854", "species_113592" ], "products": [ "species_10440850", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404" ] }, "reaction_10465457": { "compartment": "compartment_70101", "id": "reaction_10465457", "reactome": "R-DME-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441880", "species_179856" ], "products": [ "species_10465455" ], "modifiers": [], "additional_components": [ "species_179856", "Q9W0V1", "Pdk1" ] }, "reaction_10441143": { "compartment": "compartment_876", "id": "reaction_10441143", "reactome": "R-DME-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440860", "species_10440877" ], "products": [ "species_10440879" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "FBgn0028978", "Q9V3Z1", "FBgn0028978", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10441141": { "compartment": "compartment_70101", "id": "reaction_10441141", "reactome": "R-DME-199425", "name": "PHLPP dephosphorylates S473 in AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10440775" ], "products": [ "species_29372", "species_10441125" ], "modifiers": [ [ "species_10441138", "catalyst" ] ], "additional_components": [ "Q0E8W8", "FBgn0035008", "species_266099" ] }, "reaction_10489428": { "compartment": "compartment_70101", "id": "reaction_10489428", "reactome": "R-DME-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440527" ], "products": [ "species_29370", "species_10489416" ], "modifiers": [ [ "species_10489425", "catalyst" ], [ "species_1806240", "catalyst" ] ], "additional_components": [] }, "reaction_10465529": { "compartment": "compartment_70101", "id": "reaction_10465529", "reactome": "R-DME-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465526", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "P91634", "Pi3K92E", "Q9XTN2", "chico", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "Q9NHV9", "FBgn0040068", "species_179838", "Q9VFI0", "FBgn0020299", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10487135": { "compartment": "compartment_70101", "id": "reaction_10487135", "reactome": "R-DME-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10440775" ], "products": [ "species_29372", "species_10446639" ], "modifiers": [ [ "species_10487126", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q8IN89", "FBgn0042693", "Q9VXB7", "FBgn0052568" ] }, "reaction_10493536": { "compartment": "compartment_70101", "id": "reaction_10493536", "reactome": "R-DME-8948832", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493530", "species_10426987" ], "products": [ "species_10488409" ], "modifiers": [ [ "species_10468669", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0036897" ] }, "reaction_10488401": { "compartment": "compartment_70101", "id": "reaction_10488401", "reactome": "R-DME-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441147" ], "products": [ "species_10488399", "species_29370" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10486309": { "compartment": "compartment_70101", "id": "reaction_10486309", "reactome": "R-DME-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10486306" ], "products": [ "species_10426987", "species_10441147" ], "modifiers": [ [ "species_10479271", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0035402" ] }, "reaction_10487829": { "compartment": "compartment_70101", "id": "reaction_10487829", "reactome": "R-DME-8847968", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441147", "species_10487825" ], "products": [ "species_10487827" ], "modifiers": [], "additional_components": [ "Q9V9J3", "phospho-Src42A", "Q7KMQ6", "Pten" ] }, "reaction_10493528": { "compartment": "compartment_70101", "id": "reaction_10493528", "reactome": "R-DME-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10441147" ], "products": [ "species_10486306" ], "modifiers": [ [ "species_10493523", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0029152" ] }, "reaction_10487835": { "compartment": "compartment_70101", "id": "reaction_10487835", "reactome": "R-DME-8847977", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487827" ], "products": [ "species_29370", "species_10487832", "species_10487825" ], "modifiers": [ [ "species_10487827", "catalyst" ] ], "additional_components": [ "Q9V9J3", "phospho-Src42A", "Q7KMQ6", "Pten", "Q9V9J3", "phospho-Src42A", "Q7KMQ6", "Pten" ] }, "reaction_10493533": { "compartment": "compartment_70101", "id": "reaction_10493533", "reactome": "R-DME-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441147", "species_29360" ], "products": [ "species_197277", "species_10493530" ], "modifiers": [ [ "species_10468679", "catalyst" ] ], "additional_components": [ "FBgn0027508" ] }, "reaction_10488413": { "compartment": "compartment_70101", "id": "reaction_10488413", "reactome": "R-DME-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488411" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q7KMQ6", "Pten", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10486303": { "compartment": "compartment_70101", "id": "reaction_10486303", "reactome": "R-DME-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10441147" ], "products": [ "species_10486296" ], "modifiers": [ [ "species_10486300", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XYW6", "FBgn0027052", "Q9Y0H4", "FBgn0003557", "Q9VVI3", "FBgn0259174", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10441198": { "compartment": "compartment_7660", "id": "reaction_10441198", "reactome": "R-DME-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441192" ], "products": [ "species_113582", "species_10441196" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0283472", "FBgn0283472" ] }, "reaction_10441208": { "compartment": "compartment_7660", "id": "reaction_10441208", "reactome": "R-DME-199863", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441203" ], "products": [ "species_113582", "species_10441206" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0014859", "FBgn0014859" ] }, "reaction_10441123": { "compartment": "compartment_7660", "id": "reaction_10441123", "reactome": "R-DME-199299", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441097" ], "products": [ "species_113582", "species_10441108" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10434463": { "compartment": "compartment_876", "id": "reaction_10434463", "reactome": "R-DME-111970", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10434429" ], "products": [ "species_29370", "species_10434460" ], "modifiers": [ [ "species_10434454", "catalyst" ] ], "additional_components": [ "FBgn0260798", "FBgn0260798", "species_74016", "P83099", "FBgn0259680", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10434389": { "compartment": "compartment_876", "id": "reaction_10434389", "reactome": "R-DME-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10434384", "catalyst" ], [ "species_10434387", "catalyst" ] ], "additional_components": [ "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10434456": { "compartment": "compartment_70101", "id": "reaction_10434456", "reactome": "R-DME-111966", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10434429" ], "products": [ "species_10434431" ], "modifiers": [ [ "species_10434454", "inhibitor" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "FBgn0260798", "P32865", "FBgn0260798", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_74016", "P83099", "FBgn0259680", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10434412": { "compartment": "compartment_70101", "id": "reaction_10434412", "reactome": "R-DME-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434407" ], "products": [ "species_10434407" ], "modifiers": [ [ "species_10434387", "catalyst" ] ], "additional_components": [ "B7YZV4", "FBgn0264815", "B7YZV4", "FBgn0264815", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10434410": { "compartment": "compartment_70101", "id": "reaction_10434410", "reactome": "R-DME-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10434407", "catalyst" ] ], "additional_components": [ "B7YZV4", "FBgn0264815" ] }, "reaction_10440803": { "compartment": "compartment_876", "id": "reaction_10440803", "reactome": "R-DME-198314", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440788", "species_113592" ], "products": [ "species_10440800", "species_29370" ], "modifiers": [ [ "species_10440788", "catalyst" ], [ "species_112275", "catalyst" ] ], "additional_components": [ "P83099", "FBgn0259680", "P13678", "FBgn0003093", "P13678", "FBgn0003093", "P83099", "FBgn0259680", "P83099", "FBgn0259680", "P13678", "FBgn0003093" ] }, "reaction_10497028": { "compartment": "compartment_876", "id": "reaction_10497028", "reactome": "R-DME-9029150", "name": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497022", "species_10497024" ], "products": [ "species_10497026" ], "modifiers": [], "additional_components": [ "Q9XYM0", "FBgn0024811", "O77086", "FBgn0259228", "Q9XTN2", "chico", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "Q9NHV9", "FBgn0040068", "Q08012", "FBgn0004638", "Q9NHV9", "FBgn0040068", "Q9XYM0", "FBgn0024811", "O77086", "FBgn0259228", "Q9XTN2", "chico", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296" ] }, "reaction_10496920": { "compartment": "compartment_876", "id": "reaction_10496920", "reactome": "R-DME-9021627", "name": "EPOR-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10496917", "catalyst" ] ], "additional_components": [ "Q9VZZ9", "FBgn0016794", "Q9XTN2", "chico", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10462046": { "compartment": "compartment_70101", "id": "reaction_10462046", "reactome": "R-DME-1912357", "name": "ITCH ubiquitinates DTX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462041", "species_10426987" ], "products": [ "species_10462043" ], "modifiers": [ [ "species_10462041", "catalyst" ] ], "additional_components": [ "Q9Y0H4", "FBgn0003557", "Q23985", "dx", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9Y0H4", "FBgn0003557", "Q23985", "dx", "Q9Y0H4", "FBgn0003557", "Q23985", "dx" ] }, "reaction_10462467": { "compartment": "compartment_70101", "id": "reaction_10462467", "reactome": "R-DME-1980125", "name": "ITCH binds DTX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462035", "species_10456470" ], "products": [ "species_10462041" ], "modifiers": [], "additional_components": [ "FBgn0003557", "Q9Y0H4", "FBgn0003557", "Q23985", "dx" ] }, "reaction_10462113": { "compartment": "compartment_70101", "id": "reaction_10462113", "reactome": "R-DME-1912382", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462097" ], "products": [ "species_10462106" ], "modifiers": [ [ "species_10462111", "inhibitor" ] ], "additional_components": [ "Q7KU08", "FBgn0051665", "Q7KU08", "FBgn0051665", "FBgn0029709" ] }, "reaction_10497378": { "compartment": "compartment_70101", "id": "reaction_10497378", "reactome": "R-DME-9604328", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10497365" ], "products": [ "species_10497371", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0051665", "FBgn0051665" ] }, "reaction_10471742": { "compartment": "compartment_17957", "id": "reaction_10471742", "reactome": "R-DME-5358336", "name": "P4HB forms mixed disulphides with Hh precursors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471730", "species_10468383" ], "products": [ "species_10471740" ], "modifiers": [], "additional_components": [ "FBgn0286818", "P54399", "FBgn0286818", "Q02936", "hh" ] }, "reaction_10471950": { "compartment": "compartment_12045", "id": "reaction_10471950", "reactome": "R-DME-5362441", "name": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471897", "species_10471918" ], "products": [ "species_10471920" ], "modifiers": [], "additional_components": [ "Q02936", "hh", "Q9VKC7", "FBgn0032398", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q02936", "hh", "Q9VKC7", "FBgn0032398" ] }, "reaction_10471948": { "compartment": "compartment_12045", "id": "reaction_10471948", "reactome": "R-DME-5362437", "name": "C-terminal Hh fragments are bound by lectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471895", "species_10471753" ], "products": [ "species_10471897" ], "modifiers": [], "additional_components": [ "FBgn0032398", "Q02936", "hh", "Q9VKC7", "FBgn0032398" ] }, "reaction_10471932": { "compartment": "compartment_12045", "id": "reaction_10471932", "reactome": "R-DME-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471920", "species_10426987" ], "products": [ "species_10471929" ], "modifiers": [ [ "species_10471920", "catalyst" ] ], "additional_components": [ "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q02936", "hh", "Q9VKC7", "FBgn0032398", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q9VKC7", "FBgn0032398", "Q02936", "hh", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q02936", "hh", "Q9VKC7", "FBgn0032398" ] }, "reaction_10471961": { "compartment": "compartment_70101", "id": "reaction_10471961", "reactome": "R-DME-5362459", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_10471929" ], "products": [ "species_10471952", "species_1132287", "species_29370", "species_10471895", "species_10471918" ], "modifiers": [ [ "species_10471929", "catalyst" ] ], "additional_components": [ "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q9VKC7", "FBgn0032398", "Q02936", "hh", "FBgn0032398", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q9VKC7", "FBgn0032398", "Q02936", "hh" ] }, "reaction_10471975": { "compartment": "compartment_876", "id": "reaction_10471975", "reactome": "R-DME-5362549", "name": "Hh-Np traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471763" ], "products": [ "species_10471934" ], "modifiers": [], "additional_components": [] }, "reaction_10471958": { "compartment": "compartment_70101", "id": "reaction_10471958", "reactome": "R-DME-5362448", "name": "Hh C-terminal fragments are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471952" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10471890": { "compartment": "compartment_17957", "id": "reaction_10471890", "reactome": "R-DME-5362386", "name": "Glycosylation of Hh", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471884" ], "products": [ "species_10471730" ], "modifiers": [], "additional_components": [] }, "reaction_10471999": { "compartment": "compartment_876", "id": "reaction_10471999", "reactome": "R-DME-5362553", "name": "NOTUM releases Hh-Np:GPC5 from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471944" ], "products": [ "species_10471991" ], "modifiers": [ [ "species_10471996", "catalyst" ] ], "additional_components": [ "Q02936", "hh", "Q24114", "dally", "Q24114", "dally", "Q02936", "hh", "FBgn0044028" ] }, "reaction_10471946": { "compartment": "compartment_876", "id": "reaction_10471946", "reactome": "R-DME-5362427", "name": "Hh-Np binds GPC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471942", "species_10471934" ], "products": [ "species_10471944" ], "modifiers": [], "additional_components": [ "Q02936", "hh", "Q24114", "dally" ] }, "reaction_10471760": { "compartment": "compartment_17957", "id": "reaction_10471760", "reactome": "R-DME-5358340", "name": "Autoproteolytic cleavage of Hh precursors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471740", "species_174672" ], "products": [ "species_10471745", "species_10471753", "species_10468383" ], "modifiers": [ [ "species_10471740", "catalyst" ] ], "additional_components": [ "P54399", "FBgn0286818", "Q02936", "hh", "FBgn0286818", "P54399", "FBgn0286818", "Q02936", "hh" ] }, "reaction_10471776": { "compartment": "compartment_17957", "id": "reaction_10471776", "reactome": "R-DME-5358343", "name": "HHAT palmitoylates Hh N-terminal fragment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471745", "species_5358339" ], "products": [ "species_10471763", "species_162743" ], "modifiers": [ [ "species_10471773", "catalyst" ] ], "additional_components": [] }, "reaction_10473197": { "compartment": "compartment_5263228", "id": "reaction_10473197", "reactome": "R-DME-5610767", "name": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472996" ], "products": [ "species_10473138" ], "modifiers": [ [ "species_10473149", "catalyst" ], [ "species_10473166", "catalyst" ], [ "species_10473195", "catalyst" ] ], "additional_components": [ "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "FBgn0030395", "Q9VPH0", "in", "O16868", "fuz", "Q7KRS6", "FBgn0016919", "Q9VRK9", "FBgn0004380", "Q9W040", "FBgn0035317", "Q9VQS5", "FBgn0031550", "Q9VMC0", "FBgn0031829" ] }, "reaction_10473035": { "compartment": "compartment_18730", "id": "reaction_10473035", "reactome": "R-DME-5610726", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473031", "species_10473003" ], "products": [ "species_10473033" ], "modifiers": [], "additional_components": [ "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264", "FBgn0015721", "Q86PC9", "FBgn0015721", "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264" ] }, "reaction_10473099": { "compartment": "compartment_5263232", "id": "reaction_10473099", "reactome": "R-DME-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473095", "species_30389" ], "products": [ "species_10473097", "species_10472975" ], "modifiers": [], "additional_components": [ "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P16905", "FBgn0259243", "P81900", "FBgn0022382", "species_30389", "P16905", "FBgn0259243", "P81900", "FBgn0022382", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10473127": { "compartment": "compartment_24337", "id": "reaction_10473127", "reactome": "R-DME-5610763", "name": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473117" ], "products": [ "species_10473121" ], "modifiers": [ [ "species_10473125", "inhibitor" ] ], "additional_components": [ "P91682", "phospho-smo", "P91682", "phospho-smo" ] }, "reaction_10472998": { "compartment": "compartment_70101", "id": "reaction_10472998", "reactome": "R-DME-5610723", "name": "GLI proteins bind SUFU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472994", "species_10472988" ], "products": [ "species_10472996" ], "modifiers": [], "additional_components": [ "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355" ] }, "reaction_10473083": { "compartment": "compartment_70101", "id": "reaction_10473083", "reactome": "R-DME-5610746", "name": "SCF(beta-TrCP) ubiquitinates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473046", "species_10426987" ], "products": [ "species_10473081" ], "modifiers": [ [ "species_10442677", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10472986": { "compartment": "compartment_70101", "id": "reaction_10472986", "reactome": "R-DME-5610722", "name": "CK1 phosphorylates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472965", "species_113592" ], "products": [ "species_29370", "species_10472983" ], "modifiers": [ [ "species_10440489", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650" ] }, "reaction_10473048": { "compartment": "compartment_70101", "id": "reaction_10473048", "reactome": "R-DME-5610732", "name": "GSK3 phosphorylates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10472983" ], "products": [ "species_29370", "species_10473046" ], "modifiers": [ [ "species_10440540", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "P83101", "FBgn0046332", "P18431", "sgg" ] }, "reaction_10473107": { "compartment": "compartment_70101", "id": "reaction_10473107", "reactome": "R-DME-5610754", "name": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473081" ], "products": [ "species_10472994", "species_10473101" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0005355", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10472978": { "compartment": "compartment_5263232", "id": "reaction_10472978", "reactome": "R-DME-5610720", "name": "PKA phosphorylates GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10472956" ], "products": [ "species_29370", "species_10472965" ], "modifiers": [ [ "species_10472975", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10473042": { "compartment": "compartment_876", "id": "reaction_10473042", "reactome": "R-DME-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10473039", "catalyst" ] ], "additional_components": [ "species_29926" ] }, "reaction_10473105": { "compartment": "compartment_70101", "id": "reaction_10473105", "reactome": "R-DME-5610752", "name": "GLI3R translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473101" ], "products": [ "species_10473103" ], "modifiers": [], "additional_components": [] }, "reaction_10473168": { "compartment": "compartment_5263232", "id": "reaction_10473168", "reactome": "R-DME-5610766", "name": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473138" ], "products": [ "species_10473144" ], "modifiers": [ [ "species_10473149", "catalyst" ], [ "species_10473156", "catalyst" ], [ "species_10473166", "catalyst" ] ], "additional_components": [ "P19538", "ci", "Q9VG38", "FBgn0005355", "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0030395", "Q0E8P6", "FBgn0023096", "Q9VSJ6", "FBgn0265102", "Q9VPH0", "in", "O16868", "fuz" ] }, "reaction_10474463": { "compartment": "compartment_5263228", "id": "reaction_10474463", "reactome": "R-DME-5635843", "name": "GLI translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474454" ], "products": [ "species_10474442" ], "modifiers": [], "additional_components": [] }, "reaction_10474461": { "compartment": "compartment_5263228", "id": "reaction_10474461", "reactome": "R-DME-5635842", "name": "ULK3 phosphorylates GLI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5632460", "species_10473130" ], "products": [ "species_5632457", "species_10474454" ], "modifiers": [ [ "species_10474435", "catalyst" ] ], "additional_components": [ "FBgn0037679" ] }, "reaction_10474491": { "compartment": "compartment_7660", "id": "reaction_10474491", "reactome": "R-DME-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474489" ], "products": [ "species_10427430", "species_10474487" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10474521": { "compartment": "compartment_70101", "id": "reaction_10474521", "reactome": "R-DME-5635868", "name": "ub-GLI is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474512" ], "products": [ "species_10426987", "species_10473055" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10474519": { "compartment": "compartment_261122", "id": "reaction_10474519", "reactome": "R-DME-5635865", "name": "SMURF1/2 dissociates from ub-PTCH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474517" ], "products": [ "species_10474372", "species_10437960" ], "modifiers": [], "additional_components": [ "Q9V853", "FBgn0029006", "P18502", "ptc", "FBgn0029006" ] }, "reaction_10474515": { "compartment": "compartment_70101", "id": "reaction_10474515", "reactome": "R-DME-5635864", "name": "NUMB:ITCH ubiquitinates GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474506", "species_10426987" ], "products": [ "species_10474512" ], "modifiers": [ [ "species_10474506", "catalyst" ] ], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci" ] }, "reaction_10474363": { "compartment": "compartment_261122", "id": "reaction_10474363", "reactome": "R-DME-5632652", "name": "Hh-Npp binds CDON and PTCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474355", "species_10473125", "species_10444875" ], "products": [ "species_10474361" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "P18502", "ptc", "Q02936", "hh" ] }, "reaction_10474508": { "compartment": "compartment_70101", "id": "reaction_10474508", "reactome": "R-DME-5635861", "name": "NUMB:ITCH binds GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472988", "species_10473055" ], "products": [ "species_10474506" ], "modifiers": [], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci" ] }, "reaction_10474376": { "compartment": "compartment_261122", "id": "reaction_10474376", "reactome": "R-DME-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474372" ], "products": [ "species_10474374" ], "modifiers": [], "additional_components": [] }, "reaction_10474504": { "compartment": "compartment_7660", "id": "reaction_10474504", "reactome": "R-DME-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10474493" ], "products": [ "species_10474489" ], "modifiers": [ [ "species_10474493", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci" ] }, "reaction_10474439": { "compartment": "compartment_18730", "id": "reaction_10474439", "reactome": "R-DME-5635839", "name": "ULK3:SUFU dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474437" ], "products": [ "species_10473136", "species_10474435" ], "modifiers": [], "additional_components": [ "Q9VHF6", "FBgn0037679", "Q9VG38", "FBgn0005355", "FBgn0005355", "FBgn0037679" ] }, "reaction_10474500": { "compartment": "compartment_7660", "id": "reaction_10474500", "reactome": "R-DME-5635855", "name": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474450", "species_10474487" ], "products": [ "species_10474493" ], "modifiers": [ [ "species_10474498", "catalyst" ] ], "additional_components": [ "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "FBgn0039201" ] }, "reaction_10474467": { "compartment": "compartment_7660", "id": "reaction_10474467", "reactome": "R-DME-5635845", "name": "GLI proteins bind CDC73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474448", "species_10434726" ], "products": [ "species_10474465" ], "modifiers": [], "additional_components": [ "FBgn0037657", "Q9VHI1", "FBgn0037657", "P19538", "ci" ] }, "reaction_10442699": { "compartment": "compartment_70101", "id": "reaction_10442699", "reactome": "R-DME-209536", "name": "IkB is ubiquitinated and degraded", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10437421" ], "products": [ "species_10442697" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q03017", "phospho-cact", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10440308": { "compartment": "compartment_13231", "id": "reaction_10440308", "reactome": "R-DME-193691", "name": "NF-kB migrates to the nucleus and turns on transcription", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10440364": { "compartment": "compartment_876", "id": "reaction_10440364", "reactome": "R-DME-193696", "name": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440360" ], "products": [ "species_10434904", "species_10440362" ], "modifiers": [], "additional_components": [ "Q9VW59", "RhoGDI", "P48148", "Rho1", "species_29420", "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476", "P48148", "Rho1", "species_29420", "Q9VW59", "RhoGDI", "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476" ] }, "reaction_10440455": { "compartment": "compartment_876", "id": "reaction_10440455", "reactome": "R-DME-194518", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434904" ], "products": [ "species_10434906" ], "modifiers": [ [ "species_10440452", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "FBgn0050440" ] }, "reaction_10496236": { "compartment": "compartment_876", "id": "reaction_10496236", "reactome": "R-DME-9012761", "name": "The p75NTR:NgR:MDGI binds RHOA-GDI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440358", "species_10440314" ], "products": [ "species_10440360" ], "modifiers": [], "additional_components": [ "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476", "Q9VW59", "RhoGDI", "P48148", "Rho1", "species_29420", "Q9VW59", "RhoGDI", "P48148", "Rho1", "species_29420", "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476" ] }, "reaction_10444395": { "compartment": "compartment_984", "id": "reaction_10444395", "reactome": "R-DME-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10444389" ], "products": [ "species_10444393" ], "modifiers": [], "additional_components": [ "FBgn0019985", "P91685", "FBgn0019985", "species_210382" ] }, "reaction_10497512": { "compartment": "compartment_984", "id": "reaction_10497512", "reactome": "R-DME-9611839", "name": "3-agonists bind ADRB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9611836", "species_10445401" ], "products": [ "species_10497510" ], "modifiers": [], "additional_components": [ "FBgn0039419", "Q9VBG4", "FBgn0039419" ] }, "reaction_10497514": { "compartment": "compartment_984", "id": "reaction_10497514", "reactome": "R-DME-9611852", "name": "ADRB3 bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10445401" ], "products": [ "species_10445403" ], "modifiers": [ [ "species_10497510", "catalyst" ], [ "species_10497386", "inhibitor" ] ], "additional_components": [ "CHEBI:28918", "species_351597", "FBgn0039419", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "Q9VBG4", "FBgn0039419", "Q9VBG4", "FBgn0039419" ] }, "reaction_10497388": { "compartment": "compartment_984", "id": "reaction_10497388", "reactome": "R-DME-9609310", "name": "-blockers bind ADRB1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9609307", "species_10445401" ], "products": [ "species_10497386" ], "modifiers": [], "additional_components": [ "FBgn0039419", "Q9VBG4", "FBgn0039419" ] }, "reaction_10446674": { "compartment": "compartment_984", "id": "reaction_10446674", "reactome": "R-DME-390663", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10445692" ], "products": [ "species_10445696" ], "modifiers": [], "additional_components": [ "CHEBI:28918", "species_351597", "FBgn0004514", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10446680": { "compartment": "compartment_984", "id": "reaction_10446680", "reactome": "R-DME-390846", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380873", "species_10445685" ], "products": [ "species_10445687" ], "modifiers": [], "additional_components": [ "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873" ] }, "reaction_10446678": { "compartment": "compartment_984", "id": "reaction_10446678", "reactome": "R-DME-390835", "name": "DRD1,5 bind DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445408", "species_380873" ], "products": [ "species_10445412" ], "modifiers": [], "additional_components": [ "FBgn0038063", "species_380873", "Q4LBB9", "FBgn0038063" ] }, "reaction_10498330": { "compartment": "compartment_984", "id": "reaction_10498330", "reactome": "R-DME-9656244", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380873", "species_10498326" ], "products": [ "species_10498328" ], "modifiers": [], "additional_components": [ "FBgn0053517", "Q8IS44", "FBgn0053517", "species_380873" ] }, "reaction_10446686": { "compartment": "compartment_984", "id": "reaction_10446686", "reactome": "R-DME-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445424", "species_114523" ], "products": [ "species_10445426" ], "modifiers": [], "additional_components": [ "P20905", "FBgn0004573", "P41596", "FBgn0011582", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582" ] }, "reaction_10446684": { "compartment": "compartment_984", "id": "reaction_10446684", "reactome": "R-DME-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445666", "species_114523" ], "products": [ "species_10445668" ], "modifiers": [], "additional_components": [ "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_114523", "P28285", "FBgn0004168", "P28286", "FBgn0263116" ] }, "reaction_10498659": { "compartment": "compartment_984", "id": "reaction_10498659", "reactome": "R-DME-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498655", "species_114523" ], "products": [ "species_10498657" ], "modifiers": [], "additional_components": [ "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_114523", "P28285", "FBgn0004168", "P28286", "FBgn0263116" ] }, "reaction_10446676": { "compartment": "compartment_984", "id": "reaction_10446676", "reactome": "R-DME-390673", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445698", "species_372533" ], "products": [ "species_10445702" ], "modifiers": [], "additional_components": [ "FBgn0000037", "species_372533", "P16395", "FBgn0000037" ] }, "reaction_10446672": { "compartment": "compartment_984", "id": "reaction_10446672", "reactome": "R-DME-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445550", "species_372533" ], "products": [ "species_10445556" ], "modifiers": [], "additional_components": [ "FBgn0000037", "species_372533", "P16395", "FBgn0000037" ] }, "reaction_10446688": { "compartment": "compartment_984", "id": "reaction_10446688", "reactome": "R-DME-391211", "name": "Trace amine-associated receptors can bind trace amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445431", "species_391200" ], "products": [ "species_10445445" ], "modifiers": [], "additional_components": [ "FBgn0029909", "species_391200", "Q9W3V5", "FBgn0029909" ] }, "reaction_10447672": { "compartment": "compartment_984", "id": "reaction_10447672", "reactome": "R-DME-419861", "name": "Melanospin is stimulated by light", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419777", "species_10445561" ], "products": [ "species_10445563" ], "modifiers": [], "additional_components": [ "FBgn0019940", "O01668", "FBgn0019940", "species_419777" ] }, "reaction_10446747": { "compartment": "compartment_984", "id": "reaction_10446747", "reactome": "R-DME-391375", "name": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445459", "species_10445450" ], "products": [ "species_10445461" ], "modifiers": [], "additional_components": [ "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "FBgn0016650", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368" ] }, "reaction_10447588": { "compartment": "compartment_984", "id": "reaction_10447588", "reactome": "R-DME-418925", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83908", "species_10445466" ], "products": [ "species_10445470" ], "modifiers": [], "additional_components": [ "FBgn0039747", "species_83908", "Q9VAA2", "FBgn0039747" ] }, "reaction_10447586": { "compartment": "compartment_984", "id": "reaction_10447586", "reactome": "R-DME-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445704", "species_83908" ], "products": [ "species_10445708" ], "modifiers": [], "additional_components": [ "FBgn0039747", "species_83908", "Q9VAA2", "FBgn0039747" ] }, "reaction_10450073": { "compartment": "compartment_984", "id": "reaction_10450073", "reactome": "R-DME-444654", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444840", "species_10445494" ], "products": [ "species_10445496" ], "modifiers": [], "additional_components": [ "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "FBgn0039747", "Q9VAA2", "FBgn0039747", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755" ] }, "reaction_10446753": { "compartment": "compartment_984", "id": "reaction_10446753", "reactome": "R-DME-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_416911", "species_10445718" ], "products": [ "species_10445720" ], "modifiers": [], "additional_components": [ "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429" ] }, "reaction_10498546": { "compartment": "compartment_984", "id": "reaction_10498546", "reactome": "R-DME-9690439", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445565", "species_416372" ], "products": [ "species_10445567" ], "modifiers": [ [ "species_10498535", "inhibitor" ] ], "additional_components": [ "FBgn0039595", "species_266074", "species_266013", "species_266033", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "Q9NBC8", "FBgn0039595" ] }, "reaction_10498537": { "compartment": "compartment_984", "id": "reaction_10498537", "reactome": "R-DME-9684627", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9684615", "species_10445565" ], "products": [ "species_10498535" ], "modifiers": [], "additional_components": [ "FBgn0039595", "Q9NBC8", "FBgn0039595" ] }, "reaction_10446757": { "compartment": "compartment_984", "id": "reaction_10446757", "reactome": "R-DME-391943", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445569", "species_416372" ], "products": [ "species_10445571" ], "modifiers": [], "additional_components": [ "FBgn0039595", "species_266074", "species_266013", "species_266033", "species_266074", "species_266013", "species_266033", "Q9NBC8", "FBgn0039595" ] }, "reaction_10446755": { "compartment": "compartment_984", "id": "reaction_10446755", "reactome": "R-DME-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445573", "species_416436" ], "products": [ "species_10445577" ], "modifiers": [], "additional_components": [ "FBgn0039595", "species_416436", "Q9NBC8", "FBgn0039595" ] }, "reaction_10447656": { "compartment": "compartment_984", "id": "reaction_10447656", "reactome": "R-DME-419334", "name": "Melatonin receptors can bind melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419339", "species_10445738" ], "products": [ "species_10445740" ], "modifiers": [], "additional_components": [ "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339" ] }, "reaction_10450092": { "compartment": "compartment_984", "id": "reaction_10450092", "reactome": "R-DME-444879", "name": "Relaxin receptor 2 binds relaxin 2 and INSL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445490", "species_10445482" ], "products": [ "species_10445492" ], "modifiers": [], "additional_components": [ "Q9VT53", "ILP4 alpha chain", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain" ] }, "reaction_10497587": { "compartment": "compartment_984", "id": "reaction_10497587", "reactome": "R-DME-9615249", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9615246", "species_10444647" ], "products": [ "species_10444713" ], "modifiers": [], "additional_components": [ "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632" ] }, "reaction_10444715": { "compartment": "compartment_984", "id": "reaction_10444715", "reactome": "R-DME-374173", "name": "AGT(34-41) binds to AGTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444709", "species_10444647" ], "products": [ "species_10444711" ], "modifiers": [ [ "species_10444713", "inhibitor" ] ], "additional_components": [ "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632" ] }, "reaction_10497589": { "compartment": "compartment_984", "id": "reaction_10497589", "reactome": "R-DME-9615348", "name": "AGT(34-41) binds to AGTR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445652", "species_10444709" ], "products": [ "species_10445654" ], "modifiers": [], "additional_components": [ "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9W533", "FBgn0025632" ] }, "reaction_10481289": { "compartment": "compartment_876", "id": "reaction_10481289", "reactome": "R-DME-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_417891" ], "products": [ "species_109277", "species_6797635" ], "modifiers": [ [ "species_10481286", "catalyst" ] ], "additional_components": [ "FBgn0037341" ] }, "reaction_10454110": { "compartment": "compartment_876", "id": "reaction_10454110", "reactome": "R-DME-749456", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445744", "species_10445742" ], "products": [ "species_10445746" ], "modifiers": [], "additional_components": [ "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10437323": { "compartment": "compartment_947587", "id": "reaction_10437323", "reactome": "R-DME-167433", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10434469" ], "products": [ "species_10437302" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10437321": { "compartment": "compartment_70101", "id": "reaction_10437321", "reactome": "R-DME-167429", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10437316" ], "products": [ "species_10434583" ], "modifiers": [ [ "species_10434215", "catalyst" ] ], "additional_components": [ "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054" ] }, "reaction_10437318": { "compartment": "compartment_70101", "id": "reaction_10437318", "reactome": "R-DME-167419", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437304" ], "products": [ "species_29420", "species_10437316" ], "modifiers": [], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P38040", "FBgn0004921", "P26308", "FBgn0001105" ] }, "reaction_10437300": { "compartment": "compartment_947587", "id": "reaction_10437300", "reactome": "R-DME-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10434217" ], "products": [ "species_29438", "species_10434469" ], "modifiers": [ [ "species_10434215", "catalyst" ] ], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054" ] }, "reaction_10498096": { "compartment": "compartment_70101", "id": "reaction_10498096", "reactome": "R-DME-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10438771", "catalyst" ] ], "additional_components": [ "FBgn0000479" ] }, "reaction_10434424": { "compartment": "compartment_70101", "id": "reaction_10434424", "reactome": "R-DME-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10434417", "catalyst" ] ], "additional_components": [ "FBgn0000479" ] }, "reaction_10438774": { "compartment": "compartment_70101", "id": "reaction_10438774", "reactome": "R-DME-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438768", "species_113592" ], "products": [ "species_10438771", "species_29370" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "FBgn0000479", "FBgn0000479", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10437758": { "compartment": "compartment_876", "id": "reaction_10437758", "reactome": "R-DME-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437751" ], "products": [ "species_29372", "species_10437755" ], "modifiers": [ [ "species_10437751", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "P20353", "FBgn0001104", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437771": { "compartment": "compartment_876", "id": "reaction_10437771", "reactome": "R-DME-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437769" ], "products": [ "species_10434384", "species_10437767", "species_10437753" ], "modifiers": [], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "species_29420", "P20353", "FBgn0001104", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420" ] }, "reaction_10437783": { "compartment": "compartment_876", "id": "reaction_10437783", "reactome": "R-DME-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437751" ], "products": [ "species_29372", "species_10437769" ], "modifiers": [ [ "species_10437751", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437760": { "compartment": "compartment_876", "id": "reaction_10437760", "reactome": "R-DME-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437749", "species_10437740" ], "products": [ "species_10437751" ], "modifiers": [], "additional_components": [ "P20353", "FBgn0001104", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10434222": { "compartment": "compartment_70101", "id": "reaction_10434222", "reactome": "R-DME-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10434219", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10434471": { "compartment": "compartment_70101", "id": "reaction_10434471", "reactome": "R-DME-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10434219" ], "products": [ "species_29372", "species_10434469", "species_10434186" ], "modifiers": [], "additional_components": [ "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P25455", "FBgn0004611", "P13217", "FBgn0262738" ] }, "reaction_10437774": { "compartment": "compartment_876", "id": "reaction_10437774", "reactome": "R-DME-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10437762", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437765": { "compartment": "compartment_876", "id": "reaction_10437765", "reactome": "R-DME-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434384", "species_10437740" ], "products": [ "species_10437762" ], "modifiers": [ [ "species_10434384", "catalyst" ] ], "additional_components": [ "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437781": { "compartment": "compartment_876", "id": "reaction_10437781", "reactome": "R-DME-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437762" ], "products": [ "species_10437776", "species_29372" ], "modifiers": [ [ "species_10437762", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437778": { "compartment": "compartment_876", "id": "reaction_10437778", "reactome": "R-DME-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437776" ], "products": [ "species_10434384", "species_10437753" ], "modifiers": [], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420" ] }, "reaction_10454108": { "compartment": "compartment_984", "id": "reaction_10454108", "reactome": "R-DME-749454", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445750" ], "products": [ "species_10434579", "species_10437747", "species_10445742" ], "modifiers": [], "additional_components": [ "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "P20353", "FBgn0001104", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P20353", "FBgn0001104", "species_29438", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10495699": { "compartment": "compartment_876", "id": "reaction_10495699", "reactome": "R-DME-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495697" ], "products": [ "species_10495695", "species_10437767" ], "modifiers": [], "additional_components": [ "species_29420", "P20353", "FBgn0001104", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "species_29420", "P20353", "FBgn0001104" ] }, "reaction_10495369": { "compartment": "compartment_876", "id": "reaction_10495369", "reactome": "R-DME-8964242", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10495361" ], "products": [ "species_29370", "species_10495366" ], "modifiers": [ [ "species_10495361", "catalyst" ] ], "additional_components": [ "P20353", "FBgn0001104", "species_29438", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "P20353", "FBgn0001104", "species_29438", "P20353", "FBgn0001104", "species_29438", "P00528", "FBgn0262733" ] }, "reaction_10495371": { "compartment": "compartment_70101", "id": "reaction_10495371", "reactome": "R-DME-8964329", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495366" ], "products": [ "species_10437747", "species_10495364" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "P20353", "FBgn0001104", "species_29438", "P20353", "FBgn0001104", "species_29438", "FBgn0262733" ] }, "reaction_10495707": { "compartment": "compartment_876", "id": "reaction_10495707", "reactome": "R-DME-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495695", "species_10437747" ], "products": [ "species_10495705" ], "modifiers": [], "additional_components": [ "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "P20353", "FBgn0001104", "species_29438", "P20353", "FBgn0001104", "species_29438", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927" ] }, "reaction_10454114": { "compartment": "compartment_876", "id": "reaction_10454114", "reactome": "R-DME-751001", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10437767" ], "products": [ "species_10445744" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P20353", "FBgn0001104", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10495710": { "compartment": "compartment_876", "id": "reaction_10495710", "reactome": "R-DME-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495705" ], "products": [ "species_29372", "species_10495697" ], "modifiers": [ [ "species_10495705", "catalyst" ] ], "additional_components": [ "P20353", "FBgn0001104", "species_29438", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "species_29420", "P20353", "FBgn0001104", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "P20353", "FBgn0001104", "species_29438", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927" ] }, "reaction_10445760": { "compartment": "compartment_947587", "id": "reaction_10445760", "reactome": "R-DME-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10445746" ], "products": [ "species_29420", "species_10445750" ], "modifiers": [ [ "species_10445746", "catalyst" ], [ "species_10445756", "inhibitor" ] ], "additional_components": [ "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "P20353", "FBgn0001104", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "FBgn0040080" ] }, "reaction_10454106": { "compartment": "compartment_70101", "id": "reaction_10454106", "reactome": "R-DME-749453", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10454097" ], "products": [ "species_29420", "species_10454103" ], "modifiers": [ [ "species_10454097", "catalyst" ] ], "additional_components": [ "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10447293": { "compartment": "compartment_876", "id": "reaction_10447293", "reactome": "R-DME-416516", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434217", "species_10434429" ], "products": [ "species_10447291" ], "modifiers": [], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "FBgn0260798", "P32865", "FBgn0260798", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10495715": { "compartment": "compartment_876", "id": "reaction_10495715", "reactome": "R-DME-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495701" ], "products": [ "species_29372", "species_10495712" ], "modifiers": [ [ "species_10495701", "catalyst" ] ], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q8T017", "FBgn0028743", "Q8T017", "FBgn0028743", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q8T017", "FBgn0028743" ] }, "reaction_10447579": { "compartment": "compartment_876", "id": "reaction_10447579", "reactome": "R-DME-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434217" ], "products": [ "species_10434979" ], "modifiers": [ [ "species_10434217", "catalyst" ], [ "species_10447577", "catalyst" ] ], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "FBgn0028743" ] }, "reaction_10495717": { "compartment": "compartment_876", "id": "reaction_10495717", "reactome": "R-DME-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495712" ], "products": [ "species_10434979", "species_10447577" ], "modifiers": [], "additional_components": [ "Q8T017", "FBgn0028743", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "FBgn0028743" ] }, "reaction_10445588": { "compartment": "compartment_70101", "id": "reaction_10445588", "reactome": "R-DME-379048", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10445581" ], "products": [ "species_29420", "species_10445583" ], "modifiers": [ [ "species_10445585", "catalyst" ] ], "additional_components": [ "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9NBC8", "FBgn0039595", "species_266013" ] }, "reaction_10447284": { "compartment": "compartment_70101", "id": "reaction_10447284", "reactome": "R-DME-400586", "name": "G alpha (q) binds to Trio family RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447280", "species_10434217" ], "products": [ "species_10447282" ], "modifiers": [], "additional_components": [ "FBgn0024277", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q7KVD1", "FBgn0024277" ] }, "reaction_10453966": { "compartment": "compartment_876", "id": "reaction_10453966", "reactome": "R-DME-749448", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434981", "species_10445579" ], "products": [ "species_10445581" ], "modifiers": [], "additional_components": [ "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10454089": { "compartment": "compartment_984", "id": "reaction_10454089", "reactome": "R-DME-749452", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445583" ], "products": [ "species_10454081", "species_10434579", "species_10454087", "species_10434217" ], "modifiers": [], "additional_components": [ "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VFW6", "FBgn0038139", "Q9VFW5", "FBgn0038140", "Q8ITC9", "FBgn0038201", "Q8ITC7", "FBgn0037100", "Q9NBC8", "FBgn0039595", "Q9VML9", "FBgn0085410", "O01668", "FBgn0019940", "Q8IN35", "FBgn0038880", "Q7KTL9", "FBgn0025595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "P16395", "FBgn0000037", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q4V622", "FBgn0033058", "A1ZAX0", "FBgn0050106", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_74016", "species_29370", "species_419777", "species_113592", "species_210382", "species_163953", "species_1562550", "species_114523", "species_2161759", "P14599", "FBgn0000108", "CHEBI:28716", "species_3632881", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_9024011", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "species_29444", "species_29468", "species_113585", "species_417891", "CHEBI:28918", "species_351597", "species_205687", "CHEBI:52450", "species_29460", "CHEBI:31011", "CHEBI:30772", "species_29416", "CHEBI:30768", "CHEBI:50122", "species_33549", "CHEBI:42504", "species_372533", "species_266074", "species_266013", "species_266033", "species_416436", "CHEBI:17120", "species_209849", "species_390899", "CHEBI:15627", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_879535", "species_265287", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10495703": { "compartment": "compartment_876", "id": "reaction_10495703", "reactome": "R-DME-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447577", "species_10434217" ], "products": [ "species_10495701" ], "modifiers": [], "additional_components": [ "FBgn0028743", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q8T017", "FBgn0028743" ] }, "reaction_10465276": { "compartment": "compartment_70101", "id": "reaction_10465276", "reactome": "R-DME-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10465273", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "P04412", "FBgn0003731", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10465281": { "compartment": "compartment_876", "id": "reaction_10465281", "reactome": "R-DME-2179413", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465278" ], "products": [ "species_10459256" ], "modifiers": [ [ "species_10447182", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "species_114519", "P05130", "FBgn0003091" ] }, "reaction_10447184": { "compartment": "compartment_876", "id": "reaction_10447184", "reactome": "R-DME-400015", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434436", "species_114519" ], "products": [ "species_10447182" ], "modifiers": [], "additional_components": [ "FBgn0003091", "species_114519", "P05130", "FBgn0003091" ] }, "reaction_10454112": { "compartment": "compartment_876", "id": "reaction_10454112", "reactome": "R-DME-750993", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10434979" ], "products": [ "species_10434981" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10435008": { "compartment": "compartment_876", "id": "reaction_10435008", "reactome": "R-DME-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435003" ], "products": [ "species_10435005" ], "modifiers": [ [ "species_10434219", "catalyst" ] ], "additional_components": [ "species_179856", "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "species_114519", "species_114520", "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10498738": { "compartment": "compartment_70101", "id": "reaction_10498738", "reactome": "R-DME-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10434417", "catalyst" ] ], "additional_components": [ "FBgn0000479" ] }, "reaction_10445545": { "compartment": "compartment_70101", "id": "reaction_10445545", "reactome": "R-DME-379044", "name": "Liganded Gs-activating GPCR acts as a GEF for Gs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445536", "species_29438" ], "products": [ "species_29420", "species_10445542" ], "modifiers": [ [ "species_10445536", "catalyst" ] ], "additional_components": [ "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "species_391200", "Q9W3V5", "FBgn0029909", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "species_380873", "Q4LBB9", "FBgn0038063", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain", "Q9NBC8", "FBgn0039595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q7KTL9", "FBgn0025595", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582", "species_83908", "Q9VAA2", "FBgn0039747", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "species_391200", "Q9W3V5", "FBgn0029909", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "species_380873", "Q4LBB9", "FBgn0038063", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain", "Q9NBC8", "FBgn0039595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q7KTL9", "FBgn0025595", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29438", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "species_391200", "Q9W3V5", "FBgn0029909", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "species_380873", "Q4LBB9", "FBgn0038063", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain", "Q9NBC8", "FBgn0039595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q7KTL9", "FBgn0025595", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582" ] }, "reaction_10447560": { "compartment": "compartment_70101", "id": "reaction_10447560", "reactome": "R-DME-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10447557", "catalyst" ] ], "additional_components": [ "B7YZV4", "FBgn0264815", "Q9VFI9", "FBgn0038237", "Q9VJ79", "FBgn0085370", "Q6NNF2", "FBgn0266377", "Q9W4T4", "FBgn0000479" ] }, "reaction_10446862": { "compartment": "compartment_876", "id": "reaction_10446862", "reactome": "R-DME-398185", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444613", "species_10446856" ], "products": [ "species_10446860" ], "modifiers": [], "additional_components": [ "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "P25157", "FBgn0000384", "species_29438", "A1ZAN6", "FBgn0023172", "P25157", "FBgn0000384", "species_29438", "A1ZAN6", "FBgn0023172", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740" ] }, "reaction_10434925": { "compartment": "compartment_70101", "id": "reaction_10434925", "reactome": "R-DME-114548", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434913", "species_10434918" ], "products": [ "species_10434920" ], "modifiers": [], "additional_components": [ "P25157", "FBgn0000384", "species_29438", "FBgn0023172", "A1ZAN6", "FBgn0023172", "P25157", "FBgn0000384", "species_29438" ] }, "reaction_10447565": { "compartment": "compartment_876", "id": "reaction_10447565", "reactome": "R-DME-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446850" ], "products": [ "species_10447562" ], "modifiers": [ [ "species_10446850", "catalyst" ] ], "additional_components": [ "P25157", "FBgn0000384", "species_29438", "P25157", "FBgn0000384", "species_29420", "P25157", "FBgn0000384", "species_29438" ] }, "reaction_10454125": { "compartment": "compartment_876", "id": "reaction_10454125", "reactome": "R-DME-751039", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10447562" ], "products": [ "species_10434939" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P25157", "FBgn0000384", "species_29420", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10454123": { "compartment": "compartment_70101", "id": "reaction_10454123", "reactome": "R-DME-751029", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10454120" ], "products": [ "species_29420", "species_10454118" ], "modifiers": [ [ "species_10454120", "catalyst" ] ], "additional_components": [ "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P25157", "FBgn0000384", "species_29438", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10434923": { "compartment": "compartment_70101", "id": "reaction_10434923", "reactome": "R-DME-114544", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10434920", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "A1ZAN6", "FBgn0023172", "P25157", "FBgn0000384", "species_29438" ] }, "reaction_10446858": { "compartment": "compartment_70101", "id": "reaction_10446858", "reactome": "R-DME-398184", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442529", "species_10446850" ], "products": [ "species_10446856" ], "modifiers": [], "additional_components": [ "FBgn0023172", "P25157", "FBgn0000384", "species_29438", "P25157", "FBgn0000384", "species_29438", "A1ZAN6", "FBgn0023172" ] }, "reaction_10447654": { "compartment": "compartment_70101", "id": "reaction_10447654", "reactome": "R-DME-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447308" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10442560", "catalyst" ] ], "additional_components": [ "species_29420", "P48148", "Rho1", "P48148", "Rho1", "species_29438", "A1ZAN6", "FBgn0023172", "A1ZBA1", "FBgn0050115", "Q9W0S2", "FBgn0264707", "Q8IQ97", "FBgn0003041", "A8DZ19", "FBgn0015803", "Q9VVC6", "FBgn0261547", "Q7K4E0", "FBgn0050440", "P26675", "Sos", "P91621", "FBgn0085447", "M9PBE1", "FBgn0032796", "M9ND00", "FBgn0023388", "X2JC00", "FBgn0025836", "P25157", "FBgn0000384", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VW85", "FBgn0261556" ] }, "reaction_10497274": { "compartment": "compartment_70101", "id": "reaction_10497274", "reactome": "R-DME-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10441880", "species_10446639" ], "products": [ "species_10497272" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10495392": { "compartment": "compartment_876", "id": "reaction_10495392", "reactome": "R-DME-8964634", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495375", "species_10439137" ], "products": [ "species_10495381" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "FBgn0010341", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495379": { "compartment": "compartment_876", "id": "reaction_10495379", "reactome": "R-DME-8964599", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495377" ], "products": [ "species_10434579", "species_10439139", "species_10442520", "species_10446511" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29438", "P40793", "FBgn0010341", "FBgn0015803", "FBgn0267698" ] }, "reaction_10495384": { "compartment": "compartment_876", "id": "reaction_10495384", "reactome": "R-DME-8964604", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495381" ], "products": [ "species_10495377" ], "modifiers": [ [ "species_10495381", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495386": { "compartment": "compartment_70101", "id": "reaction_10495386", "reactome": "R-DME-8964605", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495373", "species_10434579" ], "products": [ "species_10495375" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495388": { "compartment": "compartment_876", "id": "reaction_10495388", "reactome": "R-DME-8964614", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495377" ], "products": [ "species_10495377" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495390": { "compartment": "compartment_70101", "id": "reaction_10495390", "reactome": "R-DME-8964619", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442520", "species_10446511" ], "products": [ "species_10495373" ], "modifiers": [], "additional_components": [ "FBgn0015803", "FBgn0267698", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10446527": { "compartment": "compartment_70101", "id": "reaction_10446527", "reactome": "R-DME-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446523", "species_10446509" ], "products": [ "species_10446525", "species_10446511" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698" ] }, "reaction_10478015": { "compartment": "compartment_7660", "id": "reaction_10478015", "reactome": "R-DME-5692749", "name": "CDC14A,B bind MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478007", "species_10478009" ], "products": [ "species_10478013" ], "modifiers": [], "additional_components": [ "FBgn0003256", "FBgn0031952", "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256" ] }, "reaction_10476696": { "compartment": "compartment_7660", "id": "reaction_10476696", "reactome": "R-DME-5687097", "name": "p-S857 NCOA3 binds ETV4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476692", "species_10476677" ], "products": [ "species_10476694" ], "modifiers": [], "additional_components": [ "FBgn0039225", "FBgn0041092", "M9ND53", "FBgn0041092", "Q8MRW5", "FBgn0039225" ] }, "reaction_10476719": { "compartment": "compartment_70101", "id": "reaction_10476719", "reactome": "R-DME-5687126", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476700" ], "products": [ "species_10476687" ], "modifiers": [], "additional_components": [] }, "reaction_10476715": { "compartment": "compartment_70101", "id": "reaction_10476715", "reactome": "R-DME-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476662" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0003256", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10478027": { "compartment": "compartment_7660", "id": "reaction_10478027", "reactome": "R-DME-5692764", "name": "MAPK6 binds CCND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476706", "species_10457981" ], "products": [ "species_10478025" ], "modifiers": [ [ "species_10478009", "catalyst" ] ], "additional_components": [ "FBgn0003256", "FBgn0010315", "Q7KUZ5", "FBgn0010315", "P40417", "FBgn0003256", "FBgn0031952" ] }, "reaction_10476682": { "compartment": "compartment_7660", "id": "reaction_10476682", "reactome": "R-DME-5687090", "name": "p-S MAPK6 phosphorylates NCOA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10476674" ], "products": [ "species_113582", "species_10476677" ], "modifiers": [ [ "species_10476679", "catalyst" ] ], "additional_components": [ "FBgn0041092", "FBgn0041092", "FBgn0003256" ] }, "reaction_10476712": { "compartment": "compartment_7660", "id": "reaction_10476712", "reactome": "R-DME-5687109", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476708" ], "products": [ "species_10476702" ], "modifiers": [ [ "species_10437629", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "FBgn0020497" ] }, "reaction_10478023": { "compartment": "compartment_7660", "id": "reaction_10478023", "reactome": "R-DME-5692755", "name": "CDK1 phosphorylates MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10476706" ], "products": [ "species_113582", "species_10478007" ], "modifiers": [ [ "species_10437599", "catalyst" ] ], "additional_components": [ "FBgn0003256", "FBgn0003256", "FBgn0004106" ] }, "reaction_10476710": { "compartment": "compartment_70101", "id": "reaction_10476710", "reactome": "R-DME-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476702" ], "products": [ "species_10476708" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10478020": { "compartment": "compartment_7660", "id": "reaction_10478020", "reactome": "R-DME-5692754", "name": "CDC14A,B dephosphorylate p-3S,T MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10478013" ], "products": [ "species_113550", "species_10478017" ], "modifiers": [ [ "species_10478013", "catalyst" ] ], "additional_components": [ "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256", "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256", "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256" ] }, "reaction_10476672": { "compartment": "compartment_70101", "id": "reaction_10476672", "reactome": "R-DME-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10476664" ], "products": [ "species_29370", "species_10476667" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "FBgn0003256", "FBgn0003256", "FBgn0267698" ] }, "reaction_10498144": { "compartment": "compartment_12045", "id": "reaction_10498144", "reactome": "R-DME-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498135", "species_71284" ], "products": [ "species_10498140", "species_71285" ], "modifiers": [ [ "species_10480013", "catalyst" ], [ "species_10498142", "inhibitor" ] ], "additional_components": [ "Q9VU37", "FBgn0036336", "species_1562550", "Q9VU37", "FBgn0036336", "species_1562550" ] }, "reaction_10498305": { "compartment": "compartment_17906", "id": "reaction_10498305", "reactome": "R-DME-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498284" ], "products": [ "species_10498303" ], "modifiers": [], "additional_components": [] }, "reaction_10498183": { "compartment": "compartment_876", "id": "reaction_10498183", "reactome": "R-DME-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10498179" ], "products": [ "species_10498181" ], "modifiers": [], "additional_components": [ "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096", "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096" ] }, "reaction_10498311": { "compartment": "compartment_876", "id": "reaction_10498311", "reactome": "R-DME-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469704" ], "products": [ "species_10498309" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10498186": { "compartment": "compartment_876", "id": "reaction_10498186", "reactome": "R-DME-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437905", "species_29356" ], "products": [ "species_10437907", "species_8848337" ], "modifiers": [ [ "species_10498179", "catalyst" ], [ "species_10498181", "inhibitor" ] ], "additional_components": [ "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096", "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096" ] }, "reaction_10498157": { "compartment": "compartment_70101", "id": "reaction_10498157", "reactome": "R-DME-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498147", "species_2530486" ], "products": [ "species_111294", "species_10498151" ], "modifiers": [ [ "species_10466175", "catalyst" ], [ "species_10498155", "inhibitor" ] ], "additional_components": [ "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424", "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424" ] }, "reaction_10498317": { "compartment": "compartment_70101", "id": "reaction_10498317", "reactome": "R-DME-9654523", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471169", "species_10498313" ], "products": [ "species_10498315" ], "modifiers": [], "additional_components": [ "Q06849", "FBgn0004908", "species_29438", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "Q06849", "FBgn0004908", "species_29438" ] }, "reaction_10498192": { "compartment": "compartment_12045", "id": "reaction_10498192", "reactome": "R-DME-9647999", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498151" ], "products": [ "species_10498135" ], "modifiers": [ [ "species_10498189", "catalyst" ] ], "additional_components": [ "FBgn0029121" ] }, "reaction_10498321": { "compartment": "compartment_70101", "id": "reaction_10498321", "reactome": "R-DME-9654525", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473927", "species_10498309" ], "products": [ "species_10498313" ], "modifiers": [ [ "species_10498319", "inhibitor" ] ], "additional_components": [ "FBgn0032059", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "Q9VLJ0", "FBgn0032059" ] }, "reaction_10498194": { "compartment": "compartment_12045", "id": "reaction_10498194", "reactome": "R-DME-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498140" ], "products": [ "species_10437907" ], "modifiers": [], "additional_components": [] }, "reaction_10498196": { "compartment": "compartment_876", "id": "reaction_10498196", "reactome": "R-DME-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10437899" ], "products": [ "species_10438980" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29420" ] }, "reaction_10498324": { "compartment": "compartment_876", "id": "reaction_10498324", "reactome": "R-DME-9654533", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498315" ], "products": [ "species_10471169", "species_10434387", "species_10437907", "species_10473927" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "Q06849", "FBgn0004908", "species_29438", "Q06849", "FBgn0004908", "species_29438", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "FBgn0032059" ] }, "reaction_10498293": { "compartment": "compartment_70101", "id": "reaction_10498293", "reactome": "R-DME-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437907", "species_113592" ], "products": [ "species_10498284", "species_29370" ], "modifiers": [ [ "species_10498290", "catalyst" ] ], "additional_components": [ "Q9VL34", "FBgn0032187", "Q03043", "FBgn0000721", "Q03042", "FBgn0000442", "species_30991", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10498166": { "compartment": "compartment_876", "id": "reaction_10498166", "reactome": "R-DME-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498160" ], "products": [ "species_10437905" ], "modifiers": [], "additional_components": [] }, "reaction_10498168": { "compartment": "compartment_70101", "id": "reaction_10498168", "reactome": "R-DME-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9653479", "species_10466175" ], "products": [ "species_10498155" ], "modifiers": [], "additional_components": [ "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424", "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424" ] }, "reaction_10498298": { "compartment": "compartment_12045", "id": "reaction_10498298", "reactome": "R-DME-9653514", "name": "USP17L2 deubiquitinates RCE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498189", "species_29356" ], "products": [ "species_10498295", "species_10477101" ], "modifiers": [ [ "species_10479178", "catalyst" ] ], "additional_components": [ "FBgn0029121", "FBgn0029121", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0260936" ] }, "reaction_10498300": { "compartment": "compartment_876", "id": "reaction_10498300", "reactome": "R-DME-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10437907" ], "products": [ "species_10469704" ], "modifiers": [ [ "species_10498284", "inhibitor" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10498350": { "compartment": "compartment_876", "id": "reaction_10498350", "reactome": "R-DME-9658253", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10431820" ], "products": [ "species_10498348" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "species_29438", "P08646", "RAS85D" ] }, "reaction_10498362": { "compartment": "compartment_876", "id": "reaction_10498362", "reactome": "R-DME-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498358", "species_10437914" ], "products": [ "species_10498360" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29438", "FBgn0026376", "M9PCE9", "FBgn0026376", "P08646", "RAS85D", "species_29438" ] }, "reaction_10475845": { "compartment": "compartment_876", "id": "reaction_10475845", "reactome": "R-DME-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475842", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q5BIB8", "FBgn0087011", "Q4V4U2", "FBgn0050280", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "P00528", "FBgn0262733", "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VQM8", "FBgn0085422", "Q7KTU3", "FBgn0037188", "A1ZAU6", "FBgn0034230", "Q9XTN2", "chico", "Q9VLL4", "FBgn0032042", "Q9VMF3", "FBgn0265778" ] }, "reaction_10498201": { "compartment": "compartment_876", "id": "reaction_10498201", "reactome": "R-DME-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909" ], "products": [ "species_10438980" ], "modifiers": [ [ "species_10437909", "catalyst" ] ], "additional_components": [ "species_29438", "P08646", "RAS85D", "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D" ] }, "reaction_10476045": { "compartment": "compartment_876", "id": "reaction_10476045", "reactome": "R-DME-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475910", "species_10475915" ], "products": [ "species_10475917" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0037432", "Q9VI08", "FBgn0037432", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10490146": { "compartment": "compartment_70101", "id": "reaction_10490146", "reactome": "R-DME-8868118", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10490103" ], "products": [ "species_10490143", "species_29370" ], "modifiers": [ [ "species_10490103", "catalyst" ] ], "additional_components": [ "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985" ] }, "reaction_10476043": { "compartment": "compartment_70101", "id": "reaction_10476043", "reactome": "R-DME-5675376", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10475991" ], "products": [ "species_29372", "species_10476027" ], "modifiers": [ [ "species_10476040", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q9VVW5", "FBgn0036844" ] }, "reaction_10475978": { "compartment": "compartment_20699", "id": "reaction_10475978", "reactome": "R-DME-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475782", "species_10475974" ], "products": [ "species_10475976" ], "modifiers": [], "additional_components": [ "FBgn0038256", "Q9VFG7", "FBgn0038256", "P11346", "Raf" ] }, "reaction_10476055": { "compartment": "compartment_876", "id": "reaction_10476055", "reactome": "R-DME-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476049", "species_29356" ], "products": [ "species_29372", "species_10476053" ], "modifiers": [ [ "species_10440527", "catalyst" ], [ "species_10476009", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P29310", "14-3-3zeta", "P11346", "Raf", "species_29438", "P08646", "RAS85D" ] }, "reaction_10490105": { "compartment": "compartment_70101", "id": "reaction_10490105", "reactome": "R-DME-8867654", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490101", "species_10450702" ], "products": [ "species_10490103" ], "modifiers": [], "additional_components": [ "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985" ] }, "reaction_10490108": { "compartment": "compartment_70101", "id": "reaction_10490108", "reactome": "R-DME-8867658", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490103" ], "products": [ "species_29372", "species_10490101", "species_10451567" ], "modifiers": [ [ "species_10490103", "catalyst" ] ], "additional_components": [ "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985", "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985" ] }, "reaction_10476011": { "compartment": "compartment_876", "id": "reaction_10476011", "reactome": "R-DME-5675194", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475854" ], "products": [ "species_29370", "species_10476009" ], "modifiers": [ [ "species_10475991", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256" ] }, "reaction_10476019": { "compartment": "compartment_876", "id": "reaction_10476019", "reactome": "R-DME-5675198", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475856", "species_113592" ], "products": [ "species_10476017", "species_29370" ], "modifiers": [ [ "species_10475991", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256" ] }, "reaction_10476002": { "compartment": "compartment_70101", "id": "reaction_10476002", "reactome": "R-DME-5674496", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475867" ], "products": [ "species_29370", "species_10475999" ], "modifiers": [ [ "species_10475991", "catalyst" ] ], "additional_components": [ "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256" ] }, "reaction_10497901": { "compartment": "compartment_70101", "id": "reaction_10497901", "reactome": "R-DME-9635739", "name": "PTPN7 dephosphorylates p-T,Y-MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497886", "species_29356" ], "products": [ "species_29372", "species_10497898" ], "modifiers": [ [ "species_10497886", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641", "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641", "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641" ] }, "reaction_10476064": { "compartment": "compartment_876", "id": "reaction_10476064", "reactome": "R-DME-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10475910" ], "products": [ "species_10476049", "species_29372" ], "modifiers": [ [ "species_10476061", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0005777" ] }, "reaction_10497903": { "compartment": "compartment_70101", "id": "reaction_10497903", "reactome": "R-DME-9635743", "name": "PTPN7 binds p-T,Y-MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497884", "species_10458636" ], "products": [ "species_10497886" ], "modifiers": [], "additional_components": [ "FBgn0016641", "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641" ] }, "reaction_10498198": { "compartment": "compartment_876", "id": "reaction_10498198", "reactome": "R-DME-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475919": { "compartment": "compartment_876", "id": "reaction_10475919", "reactome": "R-DME-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475906", "species_10475862", "species_10475896", "species_10433742" ], "products": [ "species_10475908" ], "modifiers": [ [ "species_10475917", "inhibitor" ] ], "additional_components": [ "Q24324", "phospho-Dsor1", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0003256", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "Q9VI08", "FBgn0037432", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475967": { "compartment": "compartment_74700", "id": "reaction_10475967", "reactome": "R-DME-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475963" ], "products": [ "species_29370", "species_10475965" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "Q24324", "phospho-Dsor1" ] }, "reaction_10498338": { "compartment": "compartment_876", "id": "reaction_10498338", "reactome": "R-DME-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10475908" ], "products": [ "species_10475929" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10475933": { "compartment": "compartment_876", "id": "reaction_10475933", "reactome": "R-DME-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475922", "species_113592" ], "products": [ "species_10475924", "species_29370" ], "modifiers": [ [ "species_10475922", "catalyst" ], [ "species_10475931", "inhibitor" ], [ "species_10475927", "inhibitor" ], [ "species_10475929", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10498340": { "compartment": "compartment_876", "id": "reaction_10498340", "reactome": "R-DME-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475922", "species_9657570" ], "products": [ "species_10475931" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10498342": { "compartment": "compartment_876", "id": "reaction_10498342", "reactome": "R-DME-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475922", "species_9657574" ], "products": [ "species_10475927" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10475944": { "compartment": "compartment_876", "id": "reaction_10475944", "reactome": "R-DME-5672980", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475924" ], "products": [ "species_10475873", "species_10475910", "species_10475896", "species_10433771" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0003256" ] }, "reaction_10475941": { "compartment": "compartment_876", "id": "reaction_10475941", "reactome": "R-DME-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475908", "species_113592" ], "products": [ "species_10475922", "species_29370" ], "modifiers": [ [ "species_10475908", "catalyst" ], [ "species_10475939", "inhibitor" ], [ "species_10475929", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10498346": { "compartment": "compartment_876", "id": "reaction_10498346", "reactome": "R-DME-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475924", "species_9657577" ], "products": [ "species_10498344" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10475987": { "compartment": "compartment_20699", "id": "reaction_10475987", "reactome": "R-DME-5674373", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475982" ], "products": [ "species_10475984", "species_29370" ], "modifiers": [ [ "species_10475982", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10475969": { "compartment": "compartment_74700", "id": "reaction_10475969", "reactome": "R-DME-5674132", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475906", "species_10475959", "species_10475961", "species_10433742" ], "products": [ "species_10475963" ], "modifiers": [], "additional_components": [ "Q24324", "phospho-Dsor1", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "P11346", "Raf", "FBgn0003256", "P40417", "FBgn0003256", "P11346", "Raf", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "Q24324", "phospho-Dsor1" ] }, "reaction_10475995": { "compartment": "compartment_7660", "id": "reaction_10475995", "reactome": "R-DME-5674387", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475991" ], "products": [ "species_10475993" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10475803": { "compartment": "compartment_70101", "id": "reaction_10475803", "reactome": "R-DME-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10475790" ], "products": [ "species_29372", "species_10475798" ], "modifiers": [ [ "species_10440527", "catalyst" ] ], "additional_components": [ "P29310", "14-3-3zeta", "P11346", "Raf", "P11346", "Raf", "P29310", "14-3-3zeta" ] }, "reaction_10475851": { "compartment": "compartment_876", "id": "reaction_10475851", "reactome": "R-DME-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475771", "species_10475742" ], "products": [ "species_10475847" ], "modifiers": [ [ "species_10475849", "catalyst" ] ], "additional_components": [ "P29310", "14-3-3zeta", "P11346", "Raf", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0030018" ] }, "reaction_10475800": { "compartment": "compartment_70101", "id": "reaction_10475800", "reactome": "R-DME-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475798" ], "products": [ "species_10432010", "species_10475742" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "P29310", "14-3-3zeta" ] }, "reaction_10475878": { "compartment": "compartment_876", "id": "reaction_10475878", "reactome": "R-DME-5672969", "name": "Phosphorylation of RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475847" ], "products": [ "species_29370", "species_10475862" ], "modifiers": [ [ "species_10475875", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10498281": { "compartment": "compartment_876", "id": "reaction_10498281", "reactome": "R-DME-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657579", "species_10475847" ], "products": [ "species_10475939" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475778": { "compartment": "compartment_876", "id": "reaction_10475778", "reactome": "R-DME-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10475769" ], "products": [ "species_10475771" ], "modifiers": [ [ "species_10475776", "catalyst" ] ], "additional_components": [ "species_29438", "P08646", "RAS85D", "P29310", "14-3-3zeta", "P11346", "Raf", "P29310", "14-3-3zeta", "P11346", "Raf", "species_29438", "P08646", "RAS85D", "FBgn0002031" ] }, "reaction_10475792": { "compartment": "compartment_70101", "id": "reaction_10475792", "reactome": "R-DME-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475782", "species_10432010" ], "products": [ "species_10475790" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "P11346", "Raf" ] }, "reaction_10433759": { "compartment": "compartment_70101", "id": "reaction_10433759", "reactome": "R-DME-109857", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433755", "species_10433740" ], "products": [ "species_10433757" ], "modifiers": [], "additional_components": [ "FBgn0003256", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10434596": { "compartment": "compartment_70101", "id": "reaction_10434596", "reactome": "R-DME-112342", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10434587" ], "products": [ "species_10433778", "species_29370" ], "modifiers": [ [ "species_10434593", "catalyst" ] ], "additional_components": [ "Q24324", "phospho-Dsor1", "FBgn0004106" ] }, "reaction_10433794": { "compartment": "compartment_70101", "id": "reaction_10433794", "reactome": "R-DME-109863", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433773" ], "products": [ "species_10433755", "species_10433771" ], "modifiers": [], "additional_components": [ "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "FBgn0003256" ] }, "reaction_10498724": { "compartment": "compartment_263163", "id": "reaction_10498724", "reactome": "R-DME-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498720", "species_10498704" ], "products": [ "species_10498722" ], "modifiers": [], "additional_components": [ "Q9VIW6", "FBgn0032782", "P54733", "FBgn0010382", "Q9V3C1", "FBgn0041174", "Q8IP45", "FBgn0261268", "Q9VCI3", "FBgn0039114", "Q9VXY7", "FBgn0030608", "Q960X8", "FBgn0031450", "P20905", "FBgn0004573", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "Q9VIW6", "FBgn0032782", "P54733", "FBgn0010382", "Q9V3C1", "FBgn0041174", "Q8IP45", "FBgn0261268", "Q9VCI3", "FBgn0039114", "Q9VXY7", "FBgn0030608", "Q960X8", "FBgn0031450", "P20905", "FBgn0004573", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011" ] }, "reaction_10498726": { "compartment": "compartment_263163", "id": "reaction_10498726", "reactome": "R-DME-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498702", "species_113592" ], "products": [ "species_10498704" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011" ] }, "reaction_10498731": { "compartment": "compartment_263163", "id": "reaction_10498731", "reactome": "R-DME-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10498704" ], "products": [ "species_29372", "species_10498728" ], "modifiers": [ [ "species_10498704", "catalyst" ] ], "additional_components": [ "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29370", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011" ] }, "reaction_10496801": { "compartment": "compartment_70101", "id": "reaction_10496801", "reactome": "R-DME-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496796" ], "products": [ "species_10496798", "species_29372" ], "modifiers": [ [ "species_10496796", "catalyst" ] ], "additional_components": [ "Q8IMX7", "Miro", "species_29438", "Q8IMX7", "Miro", "species_29420", "Q8IMX7", "Miro", "species_29438" ] }, "reaction_10496812": { "compartment": "compartment_17906", "id": "reaction_10496812", "reactome": "R-DME-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496796", "species_10496806" ], "products": [ "species_10496810" ], "modifiers": [], "additional_components": [ "Q8IMX7", "Miro", "species_29438", "FBgn0262872", "Q960V3", "FBgn0262872", "Q8IMX7", "Miro", "species_29438" ] }, "reaction_10458700": { "compartment": "compartment_876", "id": "reaction_10458700", "reactome": "R-DME-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10458697", "catalyst" ] ], "additional_components": [ "B7YZX2", "FBgn0032706" ] }, "reaction_10472658": { "compartment": "compartment_70101", "id": "reaction_10472658", "reactome": "R-DME-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10472655", "catalyst" ] ], "additional_components": [ "Q9VHE0", "FBgn0037690", "Q9VFS9", "FBgn0038165" ] }, "reaction_10472583": { "compartment": "compartment_70101", "id": "reaction_10472583", "reactome": "R-DME-5577213", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10472580", "catalyst" ] ], "additional_components": [ "Q9VRE6", "FBgn0064123", "Q24270", "FBgn0001991", "M9PD84", "FBgn0259822", "X2J9Z3", "FBgn0028863", "Q8IP22", "FBgn0261999" ] }, "reaction_10472614": { "compartment": "compartment_876", "id": "reaction_10472614", "reactome": "R-DME-5577234", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10472611", "catalyst" ] ], "additional_components": [ "P17971", "FBgn0005564", "Q9VBL2", "FBgn0039380", "Q8IR92", "FBgn0265595" ] }, "reaction_10472943": { "compartment": "compartment_876", "id": "reaction_10472943", "reactome": "R-DME-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472941" ], "products": [ "species_10472926" ], "modifiers": [], "additional_components": [ "FBgn0003416", "FBgn0003416" ] }, "reaction_10466943": { "compartment": "compartment_70101", "id": "reaction_10466943", "reactome": "R-DME-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466879" ], "products": [ "species_10466941" ], "modifiers": [], "additional_components": [ "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_74016", "Q24214", "FBgn0015614", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_1222611", "species_1562550" ] }, "reaction_10466882": { "compartment": "compartment_70101", "id": "reaction_10466882", "reactome": "R-DME-2730849", "name": "Calcineurin binds and dephosphorylates NFAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10464038", "species_10464071" ], "products": [ "species_29372", "species_10466879" ], "modifiers": [ [ "species_10464071", "catalyst" ] ], "additional_components": [ "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614" ] }, "reaction_10472924": { "compartment": "compartment_876", "id": "reaction_10472924", "reactome": "R-DME-5607734", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470925", "species_112275" ], "products": [ "species_10472922" ], "modifiers": [], "additional_components": [ "FBgn0259680", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10472939": { "compartment": "compartment_876", "id": "reaction_10472939", "reactome": "R-DME-5607746", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472922" ], "products": [ "species_10472937" ], "modifiers": [], "additional_components": [ "species_112275", "P83099", "FBgn0259680", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10472929": { "compartment": "compartment_876", "id": "reaction_10472929", "reactome": "R-DME-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10472926", "catalyst" ] ], "additional_components": [ "FBgn0003416" ] }, "reaction_10489499": { "compartment": "compartment_876", "id": "reaction_10489499", "reactome": "R-DME-8858500", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489495", "species_10489479" ], "products": [ "species_10489497" ], "modifiers": [], "additional_components": [ "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "M9NE79", "FBgn0262357", "M9PB26", "FBgn0264341", "Q59DY5", "FBgn0053533", "Q59DY6", "FBgn0053532", "Q7JY62", "FBgn0040092", "Q8IRH8", "FBgn0035199", "Q9VIX1", "FBgn0016675", "Q9VKL8", "FBgn0040096", "Q9VLM0", "FBgn0040098", "Q9VM16", "FBgn0031910", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "M9NE79", "FBgn0262357", "M9PB26", "FBgn0264341", "Q59DY5", "FBgn0053533", "Q59DY6", "FBgn0053532", "Q7JY62", "FBgn0040092", "Q8IRH8", "FBgn0035199", "Q9VIX1", "FBgn0016675", "Q9VKL8", "FBgn0040096", "Q9VLM0", "FBgn0040098", "Q9VM16", "FBgn0031910", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004" ] }, "reaction_10473885": { "compartment": "compartment_876", "id": "reaction_10473885", "reactome": "R-DME-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10446844" ], "products": [ "species_10473881" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "P11346", "Raf", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475388": { "compartment": "compartment_7660", "id": "reaction_10475388", "reactome": "R-DME-5660666", "name": "CBP and p300 binds NF-kB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447242", "species_10473850" ], "products": [ "species_10475363" ], "modifiers": [], "additional_components": [ "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "M9MS40", "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10473883": { "compartment": "compartment_876", "id": "reaction_10473883", "reactome": "R-DME-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10473881" ], "products": [ "species_29370", "species_10473870" ], "modifiers": [ [ "species_10446511", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "species_29438", "P08646", "RAS85D", "FBgn0267698" ] }, "reaction_10475386": { "compartment": "compartment_7660", "id": "reaction_10475386", "reactome": "R-DME-5660660", "name": "p300 acetylates RELA subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475363", "species_113560" ], "products": [ "species_2485002", "species_10475383" ], "modifiers": [ [ "species_10475363", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "M9MS40", "FBgn0261617", "Q94527", "Rel", "P15330", "dl", "P98149", "Dif", "M9MS40", "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10473865": { "compartment": "compartment_7660", "id": "reaction_10473865", "reactome": "R-DME-5624473", "name": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437455" ], "products": [ "species_113582", "species_10473850" ], "modifiers": [ [ "species_10473862", "catalyst" ] ], "additional_components": [ "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "Q9V3I5", "FBgn0020412", "P12370", "Pka-C1", "P16911", "FBgn0000274", "Q9VA47", "FBgn0039796" ] }, "reaction_10473879": { "compartment": "compartment_876", "id": "reaction_10473879", "reactome": "R-DME-5624486", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10473870" ], "products": [ "species_10473876", "species_29370" ], "modifiers": [ [ "species_10444516", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "species_29438", "P08646", "RAS85D", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "FBgn0262733" ] }, "reaction_10475392": { "compartment": "compartment_7660", "id": "reaction_10475392", "reactome": "R-DME-5660980", "name": "p-S276-RELA binds RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472931", "species_10473848" ], "products": [ "species_10475390" ], "modifiers": [], "additional_components": [ "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl" ] }, "reaction_10486210": { "compartment": "compartment_7660", "id": "reaction_10486210", "reactome": "R-DME-6805755", "name": "EHMT1:EHMT2 dimethylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10467611" ], "products": [ "species_10486207", "species_77502" ], "modifiers": [ [ "species_10468978", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "M9PGH7", "FBgn0040372" ] }, "reaction_10467770": { "compartment": "compartment_7660", "id": "reaction_10467770", "reactome": "R-DME-3222237", "name": "SMYD2 methylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10427813" ], "products": [ "species_77502", "species_10467762" ], "modifiers": [ [ "species_10467767", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0011566" ] }, "reaction_10486202": { "compartment": "compartment_7660", "id": "reaction_10486202", "reactome": "R-DME-6805740", "name": "SETD8 methylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10427813" ], "products": [ "species_10467744", "species_77502" ], "modifiers": [ [ "species_10486199", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0011474" ] }, "reaction_10467748": { "compartment": "compartment_7660", "id": "reaction_10467748", "reactome": "R-DME-3222116", "name": "L3MBTL1 binds TP53 monomethylated on K382", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467744", "species_10467739" ], "products": [ "species_10467746" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0002441", "Q9VB52", "FBgn0002441", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10479851": { "compartment": "compartment_12045", "id": "reaction_10479851", "reactome": "R-DME-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6786220", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_6786225" ], "modifiers": [ [ "species_10479848", "catalyst" ] ], "additional_components": [ "FBgn0015032" ] }, "reaction_10440259": { "compartment": "compartment_70101", "id": "reaction_10440259", "reactome": "R-DME-193060", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_193079", "species_29364" ], "products": [ "species_29356", "species_193066", "species_29366", "species_29460" ], "modifiers": [ [ "species_10440256", "catalyst" ] ], "additional_components": [ "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395" ] }, "reaction_10428799": { "compartment": "compartment_70101", "id": "reaction_10428799", "reactome": "R-DME-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10428796", "catalyst" ] ], "additional_components": [ "Q95RV5", "FBgn0050499", "species_111793" ] }, "reaction_10428829": { "compartment": "compartment_70101", "id": "reaction_10428829", "reactome": "R-DME-71335", "name": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790", "species_29878" ], "products": [ "species_29578", "species_29512" ], "modifiers": [ [ "species_10428814", "catalyst" ] ], "additional_components": [ "Q9VHN7", "FBgn0037607", "species_29926", "species_8878387" ] }, "reaction_10428827": { "compartment": "compartment_70101", "id": "reaction_10428827", "reactome": "R-DME-71334", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29512", "species_29878" ], "modifiers": [ [ "species_10428824", "catalyst" ] ], "additional_components": [ "Q9W1G0", "FBgn0023477" ] }, "reaction_10495142": { "compartment": "compartment_70101", "id": "reaction_10495142", "reactome": "R-DME-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_73578", "species_29370" ], "modifiers": [ [ "species_10495139", "catalyst" ] ], "additional_components": [ "FBgn0025640" ] }, "reaction_10436633": { "compartment": "compartment_70101", "id": "reaction_10436633", "reactome": "R-DME-163741", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29882", "species_29578" ], "products": [ "species_29790", "species_73578" ], "modifiers": [ [ "species_10428814", "catalyst" ] ], "additional_components": [ "Q9VHN7", "FBgn0037607", "species_29926", "species_8878387" ] }, "reaction_10495719": { "compartment": "compartment_70101", "id": "reaction_10495719", "reactome": "R-DME-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10427848", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z7P1", "FBgn0033377" ] }, "reaction_10427926": { "compartment": "compartment_70101", "id": "reaction_10427926", "reactome": "R-DME-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29366" ], "products": [ "species_70106", "species_31467", "species_29364" ], "modifiers": [ [ "species_10427923", "catalyst" ] ], "additional_components": [ "P12646", "FBgn0004057", "species_29366" ] }, "reaction_10438837": { "compartment": "compartment_70101", "id": "reaction_10438837", "reactome": "R-DME-177784", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10428804", "catalyst" ] ], "additional_components": [ "FBgn0050410" ] }, "reaction_10434100": { "compartment": "compartment_70101", "id": "reaction_10434100", "reactome": "R-DME-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10430909", "catalyst" ], [ "species_29372", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VT33", "FBgn0036030" ] }, "reaction_10430912": { "compartment": "compartment_70101", "id": "reaction_10430912", "reactome": "R-DME-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_113592" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10430909", "catalyst" ] ], "additional_components": [ "Q9VT33", "FBgn0036030" ] }, "reaction_10479918": { "compartment": "compartment_70101", "id": "reaction_10479918", "reactome": "R-DME-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10427848", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z7P1", "FBgn0033377" ] }, "reaction_10428779": { "compartment": "compartment_70101", "id": "reaction_10428779", "reactome": "R-DME-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29996", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_29732" ], "modifiers": [ [ "species_10428776", "catalyst" ] ], "additional_components": [ "P41572", "FBgn0004654" ] }, "reaction_10479915": { "compartment": "compartment_70101", "id": "reaction_10479915", "reactome": "R-DME-6787321", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787328" ], "products": [ "species_29578", "species_29510" ], "modifiers": [ [ "species_10479912", "catalyst" ] ], "additional_components": [ "FBgn0033735" ] }, "reaction_10441190": { "compartment": "compartment_70101", "id": "reaction_10441190", "reactome": "R-DME-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10428796", "catalyst" ] ], "additional_components": [ "Q95RV5", "FBgn0050499", "species_111793" ] }, "reaction_10428769": { "compartment": "compartment_70101", "id": "reaction_10428769", "reactome": "R-DME-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10428766", "catalyst" ] ], "additional_components": [ "FBgn0030239" ] }, "reaction_214393": { "compartment": "compartment_70101", "id": "reaction_214393", "reactome": "R-DME-214393", "name": "Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Phosphorylated Relish (REL) is endoproteolytically cleaved by the caspase-8 orthologue, DREDD, between residues Asp545 and Gly546 at a consensus target site for group III caspases found in the interdomain linker. The two cleavage products, REL-68 and REL-49, dissociate from DREDD.", "reactants": [ "species_214409" ], "products": [ "species_205709", "species_354270", "species_214404" ], "modifiers": [ [ "species_205876", "catalyst" ] ], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4" ] }, "reaction_209167": { "compartment": "compartment_70101", "id": "reaction_209167", "reactome": "R-DME-209167", "name": "Phosphorylated REL is cleaved by and dissociates from DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Phosphorylated Relish (REL) is endoproteolytically cleaved by the caspase-8 orthologue, DREDD, between residues Asp545 and Gly546 at a consensus target site for group III caspases found in the interdomain linker. The two cleavage products, REL-68 and REL-49, dissociate from DREDD.", "reactants": [ "species_354322" ], "products": [ "species_205709", "species_354270", "species_354317" ], "modifiers": [ [ "species_205876", "catalyst" ] ], "additional_components": [ "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_10436024": { "compartment": "compartment_12045", "id": "reaction_10436024", "reactome": "R-DME-162721", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449299" ], "products": [ "species_29420", "species_162681" ], "modifiers": [ [ "species_10436021", "catalyst" ] ], "additional_components": [ "E1JIA5", "FBgn0259933", "Q9VIU7", "FBgn0032799", "Q2PDR0", "FBgn0053977" ] }, "reaction_10457726": { "compartment": "compartment_70101", "id": "reaction_10457726", "reactome": "R-DME-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718" ], "products": [ "species_10457724" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10457736": { "compartment": "compartment_70101", "id": "reaction_10457736", "reactome": "R-DME-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457724" ], "products": [ "species_10457734" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10466124": { "compartment": "compartment_70101", "id": "reaction_10466124", "reactome": "R-DME-2514867", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113" ], "products": [ "species_83910", "species_74016" ], "modifiers": [ [ "species_10431457", "catalyst" ] ], "additional_components": [ "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_30991" ] }, "reaction_10466121": { "compartment": "compartment_70101", "id": "reaction_10466121", "reactome": "R-DME-2514865", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431457" ], "products": [ "species_30991", "species_10431455" ], "modifiers": [], "additional_components": [ "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_30991", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145" ] }, "reaction_10467853": { "compartment": "compartment_70101", "id": "reaction_10467853", "reactome": "R-DME-3229181", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10431455" ], "products": [ "species_10467851" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10466231": { "compartment": "compartment_70101", "id": "reaction_10466231", "reactome": "R-DME-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466229", "species_74016" ], "products": [ "species_10431940" ], "modifiers": [], "additional_components": [ "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303" ] }, "reaction_10431958": { "compartment": "compartment_2514888", "id": "reaction_10431958", "reactome": "R-DME-74885", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438" ], "products": [ "species_111294", "species_30991" ], "modifiers": [ [ "species_10431905", "catalyst" ], [ "species_10431946", "catalyst" ], [ "species_10431952", "catalyst" ], [ "species_10431940", "inhibitor" ], [ "species_10431954", "inhibitor" ], [ "species_10431956", "inhibitor" ] ], "additional_components": [ "FBgn0085386", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303" ] }, "reaction_10431459": { "compartment": "compartment_70101", "id": "reaction_10431459", "reactome": "R-DME-74031", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_10431455" ], "products": [ "species_10431457" ], "modifiers": [], "additional_components": [ "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_30991" ] }, "reaction_10479843": { "compartment": "compartment_70101", "id": "reaction_10479843", "reactome": "R-DME-6786205", "name": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428994", "species_71284" ], "products": [ "species_71285", "species_10479835" ], "modifiers": [ [ "species_10479840", "catalyst" ] ], "additional_components": [ "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "Q9W2L0", "FBgn0034592", "P47947", "FBgn0013348", "Q9VMT2", "FBgn0031692", "A1Z777", "FBgn0050378", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "FBgn0032857" ] }, "reaction_10466178": { "compartment": "compartment_2514888", "id": "reaction_10466178", "reactome": "R-DME-2530501", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466165", "species_2530486" ], "products": [ "species_111294", "species_10466168" ], "modifiers": [ [ "species_10466175", "catalyst" ] ], "additional_components": [ "FBgn0004921", "FBgn0004921", "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424" ] }, "reaction_10443513": { "compartment": "compartment_984", "id": "reaction_10443513", "reactome": "R-DME-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171149", "species_194276" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10443510", "catalyst" ] ], "additional_components": [ "Q9I7L9", "FBgn0042175", "Q9Y168", "FBgn0051683" ] }, "reaction_10495519": { "compartment": "compartment_984", "id": "reaction_10495519", "reactome": "R-DME-8980228", "name": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10495516", "catalyst" ] ], "additional_components": [ "A1ZAL5", "FBgn0034166", "A8DYT7", "FBgn0085477", "M9MRT1", "FBgn0032289", "M9NFL7", "FBgn0036977", "P02843", "FBgn0004045", "P02844", "FBgn0005391", "P06607", "FBgn0004047", "Q0E8T1", "FBgn0250847", "Q4V566", "FBgn0085476", "Q7K3Z8", "FBgn0032029", "Q9VB88", "FBgn0039476", "Q9VB89", "FBgn0039475", "Q9VB90", "FBgn0039474", "Q9VB91", "FBgn0039473", "Q9VB92", "FBgn0039472", "Q9VB93", "FBgn0039471", "Q9VB94", "FBgn0039470", "Q9VBQ2", "FBgn0039344", "Q9VEY9", "FBgn0038398", "Q9VJH1", "FBgn0032612", "Q9VLU1", "FBgn0031976", "Q9VRW5", "FBgn0035697", "Q9VU78", "FBgn0036367", "Q9VX01", "FBgn0030884", "Q9VX69", "FBgn0030828", "Q9VX70", "FBgn0265267", "Q9VZN6", "FBgn0035453", "Q9W304", "FBgn0030162", "Q9W448", "FBgn0029831" ] }, "reaction_10459822": { "compartment": "compartment_70616", "id": "reaction_10459822", "reactome": "R-DME-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524101", "species_110577" ], "products": [ "species_159450", "species_1524064" ], "modifiers": [ [ "species_10459819", "catalyst" ] ], "additional_components": [ "FBgn0010350" ] }, "reaction_10474159": { "compartment": "compartment_18730", "id": "reaction_10474159", "reactome": "R-DME-5625416", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474075" ], "products": [ "species_10474157" ], "modifiers": [], "additional_components": [ "Q9VUY2", "FBgn0036567", "Q9VQA6", "FBgn0028570", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q7KMS3", "FBgn0024196", "Q0E8P6", "FBgn0023096", "Q9VLB9", "FBgn0032119", "species_29438", "species_29420", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "Q9VRK9", "FBgn0004380", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9W097", "FBgn0035264", "Q9VSJ6", "FBgn0265102", "Q7KRS6", "FBgn0016919", "Q9VFL0", "FBgn0038221", "Q9W040", "FBgn0035317", "Q9VII8", "FBgn0032891", "Q9VJ72", "FBgn0032692", "Q9VK41", "FBgn0032470", "Q9VQS5", "FBgn0031550", "Q9VF41", "FBgn0038358", "Q9VMC0", "FBgn0031829", "Q9VR64", "FBgn0031196", "A1Z6F0", "FBgn0050441", "A1Z6F0", "FBgn0050441", "Q9W040", "FBgn0035317", "Q9VK41", "FBgn0032470", "Q9VF41", "FBgn0038358", "Q9VR64", "FBgn0031196", "Q9VFL0", "FBgn0038221", "Q7KRS6", "FBgn0016919", "Q9VII8", "FBgn0032891", "Q9VQS5", "FBgn0031550", "Q9VMC0", "FBgn0031829", "Q9VJ72", "FBgn0032692", "Q9VLB9", "FBgn0032119", "Q24117", "FBgn0011760", "Q7KMS3", "FBgn0024196", "Q9VQA6", "FBgn0028570", "O96860", "FBgn0026141", "Q9VUY2", "FBgn0036567", "Q0E8P6", "FBgn0023096", "A1ZBM3", "FBgn0034452", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264", "Q9VZ07", "FBgn0028421", "Q9VRK9", "FBgn0004380", "P46867", "FBgn0004381", "species_29438", "species_29420" ] }, "reaction_10474169": { "compartment": "compartment_18730", "id": "reaction_10474169", "reactome": "R-DME-5625426", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474167" ], "products": [ "species_10474163" ], "modifiers": [], "additional_components": [ "A1Z6F0", "FBgn0050441", "Q9W040", "FBgn0035317", "Q9VK41", "FBgn0032470", "Q9VF41", "FBgn0038358", "Q9VR64", "FBgn0031196", "Q9VFL0", "FBgn0038221", "Q7KRS6", "FBgn0016919", "Q9VII8", "FBgn0032891", "Q9VQS5", "FBgn0031550", "Q9VMC0", "FBgn0031829", "Q9VJ72", "FBgn0032692", "Q9VZ07", "FBgn0028421", "Q9VRK9", "FBgn0004380", "P46867", "FBgn0004381", "Q9VLB9", "FBgn0032119", "Q24117", "FBgn0011760", "Q7KMS3", "FBgn0024196", "Q9VQA6", "FBgn0028570", "O96860", "FBgn0026141", "Q9VUY2", "FBgn0036567", "Q0E8P6", "FBgn0023096", "species_29438", "species_29420", "A1ZBM3", "FBgn0034452", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9W097", "FBgn0035264", "Q9VSJ6", "FBgn0265102", "Q7KRS6", "FBgn0016919", "Q9VFL0", "FBgn0038221", "Q9W040", "FBgn0035317", "Q9VII8", "FBgn0032891", "Q9VJ72", "FBgn0032692", "Q9VK41", "FBgn0032470", "Q9VQS5", "FBgn0031550", "Q9VF41", "FBgn0038358", "Q9VMC0", "FBgn0031829", "Q9VR64", "FBgn0031196", "A1Z6F0", "FBgn0050441", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "Q9VRK9", "FBgn0004380", "Q9VUY2", "FBgn0036567", "Q9VQA6", "FBgn0028570", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q7KMS3", "FBgn0024196", "Q0E8P6", "FBgn0023096", "Q9VLB9", "FBgn0032119", "species_29438", "species_29420" ] }, "reaction_10473319": { "compartment": "compartment_20699", "id": "reaction_10473319", "reactome": "R-DME-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473317" ], "products": [ "species_10473315", "species_10473310" ], "modifiers": [], "additional_components": [ "A1Z6F0", "FBgn0050441", "A0A4D6K5M0", "FBgn0027287", "FBgn0027287", "FBgn0050441" ] }, "reaction_10473908": { "compartment": "compartment_70101", "id": "reaction_10473908", "reactome": "R-DME-5624951", "name": "TNPO1 binds KIF17 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473892", "species_10450986" ], "products": [ "species_10473894" ], "modifiers": [], "additional_components": [ "Q9V4A1", "FBgn0039925", "FBgn0024921", "Q9VRV8", "FBgn0024921", "Q9V4A1", "FBgn0039925" ] }, "reaction_10473904": { "compartment": "compartment_18730", "id": "reaction_10473904", "reactome": "R-DME-5624948", "name": "KIF17 enters the cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473894" ], "products": [ "species_10473902" ], "modifiers": [], "additional_components": [ "Q9VRV8", "FBgn0024921", "Q9V4A1", "FBgn0039925", "Q9VRV8", "FBgn0024921", "Q9V4A1", "FBgn0039925" ] }, "reaction_10458647": { "compartment": "compartment_876", "id": "reaction_10458647", "reactome": "R-DME-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458644", "catalyst" ] ], "additional_components": [ "FBgn0029761" ] }, "reaction_10458658": { "compartment": "compartment_876", "id": "reaction_10458658", "reactome": "R-DME-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458655", "catalyst" ] ], "additional_components": [ "Q7KVW5", "FBgn0029761" ] }, "reaction_10448363": { "compartment": "compartment_70101", "id": "reaction_10448363", "reactome": "R-DME-426522", "name": "Nonendonucleolytic RISC binds exactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523", "species_10448341", "species_10448348" ], "products": [ "species_10448361" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035", "FBgn0051992", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035" ] }, "reaction_10448359": { "compartment": "compartment_70101", "id": "reaction_10448359", "reactome": "R-DME-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10448333", "catalyst" ] ], "additional_components": [ "Q32KD4", "FBgn0262739" ] }, "reaction_10448356": { "compartment": "compartment_70101", "id": "reaction_10448356", "reactome": "R-DME-426489", "name": "RISC binds inexactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448343", "species_426515", "species_10448348" ], "products": [ "species_10448354" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035", "FBgn0051992", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035" ] }, "reaction_10448329": { "compartment": "compartment_70101", "id": "reaction_10448329", "reactome": "R-DME-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10442303" ], "products": [ "species_10448326" ], "modifiers": [ [ "species_10442303", "catalyst" ] ], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739" ] }, "reaction_10464903": { "compartment": "compartment_70101", "id": "reaction_10464903", "reactome": "R-DME-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448326" ], "products": [ "species_10464891" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016" ] }, "reaction_10496968": { "compartment": "compartment_70101", "id": "reaction_10496968", "reactome": "R-DME-9023909", "name": "C3PO hydrolyzes cleaved passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496953" ], "products": [ "species_10448331" ], "modifiers": [ [ "species_10496965", "catalyst" ] ], "additional_components": [ "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739", "Q9VF77", "FBgn0038327", "Q7JVK6", "FBgn0033528" ] }, "reaction_10464901": { "compartment": "compartment_70101", "id": "reaction_10464901", "reactome": "R-DME-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464891" ], "products": [ "species_10464899" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VLW8", "FBgn0031951" ] }, "reaction_10496971": { "compartment": "compartment_70101", "id": "reaction_10496971", "reactome": "R-DME-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464877" ], "products": [ "species_10496953" ], "modifiers": [ [ "species_10464877", "catalyst" ] ], "additional_components": [ "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739" ] }, "reaction_10472623": { "compartment": "compartment_70101", "id": "reaction_10472623", "reactome": "R-DME-5578712", "name": "Importin-8 binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443060", "species_10472619" ], "products": [ "species_10472621" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "FBgn0026252", "Q9VSD6", "FBgn0026252", "Q32KD4", "FBgn0262739" ] }, "reaction_10472637": { "compartment": "compartment_70101", "id": "reaction_10472637", "reactome": "R-DME-5578744", "name": "Importin-8 imports AGO2:miRNA into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472625", "species_10472621" ], "products": [ "species_10472631", "species_10472635" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9VZ23", "FBgn0020255", "species_29438", "Q9VSD6", "FBgn0026252", "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739", "Q9VSD6", "FBgn0026252", "species_29438", "Q9VZ23", "FBgn0020255", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10472668": { "compartment": "compartment_70101", "id": "reaction_10472668", "reactome": "R-DME-5578966", "name": "TNRC6A:AGO2:miRNA is transported into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472660" ], "products": [ "species_10472666" ], "modifiers": [], "additional_components": [ "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739" ] }, "reaction_10472662": { "compartment": "compartment_70101", "id": "reaction_10472662", "reactome": "R-DME-5578965", "name": "TNRC6A binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443060", "species_10448348" ], "products": [ "species_10472660" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "FBgn0051992", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739" ] }, "reaction_10458332": { "compartment": "compartment_70101", "id": "reaction_10458332", "reactome": "R-DME-1247960", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10458319" ], "products": [ "species_29370", "species_10458329" ], "modifiers": [ [ "species_10450887", "catalyst" ] ], "additional_components": [ "FBgn0261524" ] }, "reaction_10433309": { "compartment": "compartment_7660", "id": "reaction_10433309", "reactome": "R-DME-77615", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10433302" ], "products": [ "species_76230", "species_10433306" ], "modifiers": [ [ "species_10433300", "catalyst" ] ], "additional_components": [ "Q9NII1", "FBgn0026086", "Q9NII1", "FBgn0026086", "Q9NII1", "FBgn0026086" ] }, "reaction_10465775": { "compartment": "compartment_876", "id": "reaction_10465775", "reactome": "R-DME-2424477", "name": "SOS mediated nucleotide exchange of RAS (SHC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10465772", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_209218": { "compartment": "compartment_7660", "id": "reaction_209218", "reactome": "R-DME-209218", "name": "Phosphorylated DL/DIF dimer activates transcription", "reversible": "false", "notes": "In the nucleus, phosphorylated Dorsal/Dif (DL/DIF) homodimer binds to its target genes and activates transcription.", "reactants": [ "species_214725" ], "products": [ "species_214725" ], "modifiers": [], "additional_components": [ "P15330", "dl", "P98149", "Dif", "P15330", "dl", "P98149", "Dif" ] }, "reaction_209295": { "compartment": "compartment_13231", "id": "reaction_209295", "reactome": "R-DME-209295", "name": "Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated Dorsal/Dif (DL/DIF) homodimer, now free from its cytoplasmic anchor, Cactus (CACT), is imported to the nucleus. Phosphorylation of the DL/DIF homodimer is important for its nuclear localisation.", "reactants": [ "species_214728" ], "products": [ "species_214725" ], "modifiers": [], "additional_components": [ "P15330", "dl", "P98149", "Dif", "P15330", "dl", "P98149", "Dif" ] }, "reaction_209072": { "compartment": "compartment_70101", "id": "reaction_209072", "reactome": "R-DME-209072", "name": "PLL kinase binds to TL:MYD88:TUB 'signalling complex'", "reversible": "false", "notes": "The Ser/Thr kinase Pelle (PLL) binds to the death domain of Tube (TUB) in the 'signalling complex' at the plasma membrane. On binding to TUB, PLL is activated.", "reactants": [ "species_206600", "species_206070" ], "products": [ "species_206889" ], "modifiers": [], "additional_components": [ "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214878": { "compartment": "compartment_70101", "id": "reaction_214878", "reactome": "R-DME-214878", "name": "PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex'", "reversible": "false", "notes": "The Ser/Thr kinase Pelle (PLL) binds to the death domain of Tube (TUB) in the 'signalling complex' at the plasma membrane. On binding to TUB, PLL is activated.", "reactants": [ "species_206070", "species_214743" ], "products": [ "species_214742" ], "modifiers": [], "additional_components": [ "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_10436619": { "compartment": "compartment_7660", "id": "reaction_10436619", "reactome": "R-DME-163670", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436615" ], "products": [ "species_10436617" ], "modifiers": [], "additional_components": [ "FBgn0032940", "FBgn0032940" ] }, "reaction_10436721": { "compartment": "compartment_70101", "id": "reaction_10436721", "reactome": "R-DME-164423", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436617" ], "products": [ "species_10436615" ], "modifiers": [], "additional_components": [ "FBgn0032940", "FBgn0032940" ] }, "reaction_10477549": { "compartment": "compartment_161320", "id": "reaction_10477549", "reactome": "R-DME-5690046", "name": "PPT2 hydrolyses PALMCoA to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690537", "species_1605715" ], "products": [ "species_1678675", "species_5690516" ], "modifiers": [ [ "species_10477546", "catalyst" ] ], "additional_components": [ "FBgn0032358" ] }, "reaction_10432490": { "compartment": "compartment_70101", "id": "reaction_10432490", "reactome": "R-DME-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_76183", "species_29364", "species_29508" ], "products": [ "species_29356", "species_113528", "species_29366", "species_3632881", "species_76194" ], "modifiers": [ [ "species_10432487", "catalyst" ] ], "additional_components": [ "B7Z001", "FBgn0283427" ] }, "reaction_10477738": { "compartment": "compartment_12045", "id": "reaction_10477738", "reactome": "R-DME-5690565", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10477735", "catalyst" ] ], "additional_components": [ "Q7K4Y0", "FBgn0086687" ] }, "reaction_10432425": { "compartment": "compartment_70101", "id": "reaction_10432425", "reactome": "R-DME-75849", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654", "species_198498" ], "products": [ "species_76190", "species_113544" ], "modifiers": [ [ "species_10432422", "catalyst" ] ], "additional_components": [ "FBgn0037912" ] }, "reaction_10441352": { "compartment": "compartment_70101", "id": "reaction_10441352", "reactome": "R-DME-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10432436", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "FBgn0033246" ] }, "reaction_10441469": { "compartment": "compartment_70101", "id": "reaction_10441469", "reactome": "R-DME-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10441466", "catalyst" ] ], "additional_components": [ "FBgn0036821" ] }, "reaction_10476157": { "compartment": "compartment_12045", "id": "reaction_10476157", "reactome": "R-DME-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10476154", "catalyst" ] ], "additional_components": [ "Q9VKD2", "FBgn0032394" ] }, "reaction_10453291": { "compartment": "compartment_70101", "id": "reaction_10453291", "reactome": "R-DME-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10453288", "catalyst" ] ], "additional_components": [ "Q9VV87", "FBgn0260960", "Q9VHX7", "FBgn0037534", "Q6NN18", "FBgn0034382", "Q9VCY6", "FBgn0038986", "Q9VH59", "FBgn0037761", "Q4V3H4", "FBgn0037764", "Q9VCY5", "FBgn0053110", "Q9VH58", "FBgn0037762", "A1ZBD2", "FBgn0034383", "Q9VCT3", "FBgn0039030", "Q9VH57", "FBgn0037763", "Q95T98", "FBgn0051523", "Q9VH55", "FBgn0037765", "Q8SXD1", "FBgn0050008", "Q9VCZ0", "FBgn0038983", "Q8IMY2", "FBgn0051141", "Q9VCY7", "FBgn0260942" ] }, "reaction_10479066": { "compartment": "compartment_70101", "id": "reaction_10479066", "reactome": "R-DME-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5695985", "species_76194" ], "products": [ "species_111294", "species_5695971", "species_76577" ], "modifiers": [ [ "species_10479063", "catalyst" ] ], "additional_components": [ "Q9V3S9", "FBgn0027348", "Q9V3U0", "FBgn0286723" ] }, "reaction_10479082": { "compartment": "compartment_5460", "id": "reaction_10479082", "reactome": "R-DME-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5696008", "species_113593" ], "products": [ "species_159448", "species_159450", "species_5696003" ], "modifiers": [ [ "species_10479079", "catalyst" ] ], "additional_components": [ "FBgn0029945" ] }, "reaction_10453338": { "compartment": "compartment_70101", "id": "reaction_10453338", "reactome": "R-DME-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10440266", "catalyst" ] ], "additional_components": [ "FBgn0029975" ] }, "reaction_10453335": { "compartment": "compartment_70101", "id": "reaction_10453335", "reactome": "R-DME-548815", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548794" ], "products": [ "species_113528", "species_548829", "species_76194" ], "modifiers": [ [ "species_10453327", "catalyst" ] ], "additional_components": [ "Q9VCY6", "FBgn0038986", "Q9VCY5", "FBgn0053110", "Q9VCT3", "FBgn0039030", "Q95T98", "FBgn0051523", "Q8SXD1", "FBgn0050008", "Q8IMY2", "FBgn0051141", "Q6NN18", "FBgn0034382", "Q4V3H4", "FBgn0037764", "A1ZBD2", "FBgn0034383", "Q9VHX7", "FBgn0037534", "Q9VH59", "FBgn0037761", "Q9VH58", "FBgn0037762", "Q9VH57", "FBgn0037763", "Q9VH55", "FBgn0037765", "Q9VCZ0", "FBgn0038983", "Q9VCY7", "FBgn0260942" ] }, "reaction_10453332": { "compartment": "compartment_70101", "id": "reaction_10453332", "reactome": "R-DME-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10453329", "catalyst" ] ], "additional_components": [ "Q9VCY6", "FBgn0038986", "Q9VCY5", "FBgn0053110", "Q9VCT3", "FBgn0039030", "Q95T98", "FBgn0051523", "Q8SXD1", "FBgn0050008", "Q8IMY2", "FBgn0051141", "Q6NN18", "FBgn0034382", "Q4V3H4", "FBgn0037764", "A1ZBD2", "FBgn0034383", "Q9VHX7", "FBgn0037534", "Q9VH59", "FBgn0037761", "Q9VH58", "FBgn0037762", "Q9VH57", "FBgn0037763", "Q9VH55", "FBgn0037765", "Q9VCZ0", "FBgn0038983", "Q9VCY7", "FBgn0260942", "Q9VV87", "FBgn0260960" ] }, "reaction_10453348": { "compartment": "compartment_70101", "id": "reaction_10453348", "reactome": "R-DME-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_428139", "species_29366" ], "modifiers": [ [ "species_10453343", "catalyst" ] ], "additional_components": [ "FBgn0035471" ] }, "reaction_10436643": { "compartment": "compartment_70101", "id": "reaction_10436643", "reactome": "R-DME-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432485" ], "products": [ "species_10432487" ], "modifiers": [], "additional_components": [ "FBgn0283427", "B7Z001", "FBgn0283427" ] }, "reaction_10495309": { "compartment": "compartment_5460", "id": "reaction_10495309", "reactome": "R-DME-8957389", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8957387" ], "products": [ "species_8957386", "species_113521" ], "modifiers": [ [ "species_10495306", "catalyst" ] ], "additional_components": [ "FBgn0038425" ] }, "reaction_10432417": { "compartment": "compartment_70101", "id": "reaction_10432417", "reactome": "R-DME-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_113592", "species_76194" ], "products": [ "species_29372", "species_29370", "species_76183", "species_76213" ], "modifiers": [ [ "species_10432414", "catalyst" ] ], "additional_components": [ "Q7KN85", "FBgn0020236" ] }, "reaction_10487694": { "compartment": "compartment_12045", "id": "reaction_10487694", "reactome": "R-DME-8847579", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10487691", "catalyst" ] ], "additional_components": [ "Q9VG68", "FBgn0043043", "Q9VA93", "FBgn0039755", "Q9VTD4", "FBgn0029172", "Q9VA94", "FBgn0039754", "Q7K4Y0", "FBgn0086687", "Q9VFX5", "FBgn0038130", "Q9VA92", "FBgn0039756" ] }, "reaction_10477728": { "compartment": "compartment_161320", "id": "reaction_10477728", "reactome": "R-DME-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_5690533" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10477725", "catalyst" ] ], "additional_components": [ "species_3632881", "species_6785219", "FBgn0030057" ] }, "reaction_10495043": { "compartment": "compartment_17947", "id": "reaction_10495043", "reactome": "R-DME-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495031" ], "products": [ "species_10427563", "species_10495040" ], "modifiers": [ [ "species_10495031", "catalyst" ] ], "additional_components": [ "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609" ] }, "reaction_10495033": { "compartment": "compartment_17947", "id": "reaction_10495033", "reactome": "R-DME-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495029", "species_10495027" ], "products": [ "species_10495031" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609" ] }, "reaction_10493243": { "compartment": "compartment_7660", "id": "reaction_10493243", "reactome": "R-DME-8942099", "name": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434753", "species_10467826", "species_10493239", "species_10493237", "species_10493232" ], "products": [ "species_10493241" ], "modifiers": [], "additional_components": [ "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "FBgn0001198", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0030812", "Q9VRP9", "FBgn0086694", "Q9VRP9", "FBgn0086694", "Q9VX88", "FBgn0030812", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P02283", "FBgn0001198", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637" ] }, "reaction_10493246": { "compartment": "compartment_7660", "id": "reaction_10493246", "reactome": "R-DME-8942101", "name": "RNF20:RNF40 monoubiquitinates Histone H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493241" ], "products": [ "species_10434753", "species_10488716", "species_10477560", "species_10493237", "species_10493232" ], "modifiers": [ [ "species_10493241", "catalyst" ] ], "additional_components": [ "Q9VRP9", "FBgn0086694", "Q9VX88", "FBgn0030812", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P02283", "FBgn0001198", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "FBgn0004436", "FBgn0001198", "FBgn0030812", "Q9VRP9", "FBgn0086694", "Q9VRP9", "FBgn0086694", "Q9VX88", "FBgn0030812", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P02283", "FBgn0001198", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637" ] }, "reaction_10433263": { "compartment": "compartment_7660", "id": "reaction_10433263", "reactome": "R-DME-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433237", "species_10433259" ], "products": [ "species_10433261" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186" ] }, "reaction_10433239": { "compartment": "compartment_7660", "id": "reaction_10433239", "reactome": "R-DME-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433235", "species_10433230" ], "products": [ "species_10433237" ], "modifiers": [], "additional_components": [ "FBgn0041186", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186" ] }, "reaction_10433267": { "compartment": "compartment_7660", "id": "reaction_10433267", "reactome": "R-DME-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433261" ], "products": [ "species_10433265", "species_10433259" ], "modifiers": [], "additional_components": [ "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554" ] }, "reaction_10436095": { "compartment": "compartment_12045", "id": "reaction_10436095", "reactome": "R-DME-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855667" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10436092", "catalyst" ] ], "additional_components": [ "FBgn0035464" ] }, "reaction_10436079": { "compartment": "compartment_12045", "id": "reaction_10436079", "reactome": "R-DME-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855656", "species_449229" ], "products": [ "species_8855664" ], "modifiers": [ [ "species_10436076", "catalyst" ] ], "additional_components": [ "FBgn0266438" ] }, "reaction_10436056": { "compartment": "compartment_70101", "id": "reaction_10436056", "reactome": "R-DME-162730", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_162756" ], "products": [ "species_8855657", "species_110096" ], "modifiers": [ [ "species_10436053", "catalyst" ] ], "additional_components": [ "E1JIA5", "FBgn0259933", "Q7JUM3", "FBgn0034270", "Q8MSE4", "FBgn0039405", "Q9VHX6", "FBgn0037535", "A0A2U8U156", "FBgn0035435", "Q8IR17", "FBgn0086448" ] }, "reaction_10436087": { "compartment": "compartment_12045", "id": "reaction_10436087", "reactome": "R-DME-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855659", "species_1500581" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10436084", "catalyst" ] ], "additional_components": [ "FBgn0033479" ] }, "reaction_10436103": { "compartment": "compartment_12045", "id": "reaction_10436103", "reactome": "R-DME-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855663" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10436100", "catalyst" ] ], "additional_components": [ "FBgn0265174" ] }, "reaction_10436071": { "compartment": "compartment_12045", "id": "reaction_10436071", "reactome": "R-DME-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10436068", "catalyst" ] ], "additional_components": [ "Q9VW21", "FBgn0036893", "A1Z705", "FBgn0033187" ] }, "reaction_10436004": { "compartment": "compartment_17957", "id": "reaction_10436004", "reactome": "R-DME-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_8855666", "species_76194" ], "modifiers": [ [ "species_10436001", "catalyst" ] ], "additional_components": [ "FBgn0035265" ] }, "reaction_10467548": { "compartment": "compartment_70101", "id": "reaction_10467548", "reactome": "R-DME-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467524", "species_3134861" ], "products": [ "species_10467526" ], "modifiers": [], "additional_components": [ "FBgn0032883", "Q8SWT2", "FBgn0032883" ] }, "reaction_10497380": { "compartment": "compartment_70101", "id": "reaction_10497380", "reactome": "R-DME-9604480", "name": "NFkB complex translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [ [ "species_10467540", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P24785", "FBgn0002774", "Q7K105", "MYD88" ] }, "reaction_10467546": { "compartment": "compartment_70101", "id": "reaction_10467546", "reactome": "R-DME-3134954", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467528", "species_3134861" ], "products": [ "species_10467530" ], "modifiers": [], "additional_components": [ "FBgn0002774", "P24785", "FBgn0002774" ] }, "reaction_10467544": { "compartment": "compartment_70101", "id": "reaction_10467544", "reactome": "R-DME-3134953", "name": "DHX36 or DHX9 binds MyD88", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467536", "species_10467532" ], "products": [ "species_10467542" ], "modifiers": [], "additional_components": [ "P24785", "FBgn0002774", "Q8SWT2", "FBgn0032883", "P24785", "FBgn0002774", "Q7K105", "MYD88", "Q8SWT2", "FBgn0032883" ] }, "reaction_209187": { "compartment": "compartment_70101", "id": "reaction_209187", "reactome": "R-DME-209187", "name": "Further phosphorylation of CI by CKIalphaepsilon", "reversible": "false", "notes": "Previous phosphorylation of Cubitus Interruptus (CI) at Ser852 and Ser888 primes further phosphorylation by CKIalphaepsilon (CKIalpha/DCO) at Ser855, Ser858, and Ser891.", "reactants": [ "species_113592", "species_206997" ], "products": [ "species_206766", "species_29370" ], "modifiers": [ [ "species_206577", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "P19538", "ci", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "O76324", "DCO" ] }, "reaction_209172": { "compartment": "compartment_70101", "id": "reaction_209172", "reactome": "R-DME-209172", "name": "Phosphorylation of CI by SGG", "reversible": "false", "notes": "Previous phosphorylation of Cubitus Interruptus (CI) at Ser856 and Ser892 primes Shaggy (SGG) phosphorylation at Ser884 and Ser888. Ser852 can also be phosphorylated by SGG if it hasn't been previously phosphorylated by CKIalpha/DCO.", "reactants": [ "species_206924", "species_113592" ], "products": [ "species_29370", "species_206997" ], "modifiers": [ [ "species_206898", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "P19538", "ci", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209293": { "compartment": "compartment_70101", "id": "reaction_209293", "reactome": "R-DME-209293", "name": "Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO)", "reversible": "false", "notes": "The priming phosphorylations of Cubitus Interruptus (CI) results in additional phosphorylation by kinases CKIalphaepsilon (CKIalpha/DCO) at Ser841, Ser844, Thr845, Ser849, Ser852, Ser859, Ser862, and Ser895.", "reactants": [ "species_113592", "species_206916" ], "products": [ "species_206924", "species_29370" ], "modifiers": [ [ "species_206577", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "P19538", "ci", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "O76324", "DCO" ] }, "reaction_209196": { "compartment": "compartment_70101", "id": "reaction_209196", "reactome": "R-DME-209196", "name": "Phosphorylation of CI by PKA-C1", "reversible": "false", "notes": "Cubitus Interruptus (CI) is primed for phosphorylation by Protein kinase A (PKA-C1) at Ser838, Ser856, and Ser892.", "reactants": [ "species_113592", "species_206721" ], "products": [ "species_29370", "species_206916" ], "modifiers": [ [ "species_206865", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "P19538", "ci", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "Q24170", "Phospho KSR", "P11346", "Raf", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "Q7KNQ9", "cnk", "Q8ML92", "AVE", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10457576": { "compartment": "compartment_7660", "id": "reaction_10457576", "reactome": "R-DME-997326", "name": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10454153" ], "products": [ "species_113550", "species_10457569" ], "modifiers": [ [ "species_10457573", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10448751": { "compartment": "compartment_70101", "id": "reaction_10448751", "reactome": "R-DME-428917", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10448746" ], "products": [ "species_29420", "species_10448748" ], "modifiers": [ [ "species_10448746", "catalyst" ] ], "additional_components": [ "CHEBI:15627", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "CHEBI:15627", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P25157", "FBgn0000384", "species_29438", "CHEBI:15627", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10448722": { "compartment": "compartment_70101", "id": "reaction_10448722", "reactome": "R-DME-428750", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10448717" ], "products": [ "species_29420", "species_10448719" ], "modifiers": [ [ "species_10448717", "catalyst" ] ], "additional_components": [ "CHEBI:15627", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "CHEBI:15627", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "CHEBI:15627", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10446811": { "compartment": "compartment_70101", "id": "reaction_10446811", "reactome": "R-DME-392195", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10446806" ], "products": [ "species_29420", "species_10446808" ], "modifiers": [ [ "species_10446806", "catalyst" ] ], "additional_components": [ "species_29370", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P20353", "FBgn0001104", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29370", "species_29370", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10448755": { "compartment": "compartment_70101", "id": "reaction_10448755", "reactome": "R-DME-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448753", "species_113592" ], "products": [ "species_29370", "species_10439430" ], "modifiers": [ [ "species_10434217", "catalyst" ] ], "additional_components": [ "FBgn0024846", "FBgn0024846", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10447584": { "compartment": "compartment_70101", "id": "reaction_10447584", "reactome": "R-DME-418662", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440003" ], "products": [ "species_10447582" ], "modifiers": [], "additional_components": [ "FBgn0262733", "FBgn0262733" ] }, "reaction_10433304": { "compartment": "compartment_7660", "id": "reaction_10433304", "reactome": "R-DME-77613", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10433300" ], "products": [ "species_10433302" ], "modifiers": [], "additional_components": [ "Q9NII1", "FBgn0026086", "Q9NII1", "FBgn0026086" ] }, "reaction_10434102": { "compartment": "compartment_7660", "id": "reaction_10434102", "reactome": "R-DME-111238", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433298" ], "products": [ "species_10433300" ], "modifiers": [], "additional_components": [ "FBgn0026086", "Q9NII1", "FBgn0026086" ] }, "reaction_10455818": { "compartment": "compartment_20699", "id": "reaction_10455818", "reactome": "R-DME-975829", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975819" ], "products": [ "species_205687", "species_975822" ], "modifiers": [ [ "species_10455815", "catalyst" ] ], "additional_components": [ "FBgn0039738" ] }, "reaction_10479784": { "compartment": "compartment_20699", "id": "reaction_10479784", "reactome": "R-DME-6786048", "name": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_6786371" ], "products": [ "species_742343", "species_6786380" ], "modifiers": [ [ "species_10479781", "catalyst" ] ], "additional_components": [ "Q8IRG5", "FBgn0035287", "Q9VMS3", "FBgn0031697", "Q9VJG5", "FBgn0032618" ] }, "reaction_10457715": { "compartment": "compartment_20699", "id": "reaction_10457715", "reactome": "R-DME-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10457712", "catalyst" ] ], "additional_components": [ "FBgn0030327" ] }, "reaction_10478179": { "compartment": "compartment_161320", "id": "reaction_10478179", "reactome": "R-DME-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10478176", "catalyst" ] ], "additional_components": [ "Q9VTJ4", "FBgn0285958" ] }, "reaction_10455810": { "compartment": "compartment_20699", "id": "reaction_10455810", "reactome": "R-DME-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_964752", "species_975819" ], "modifiers": [ [ "species_10455807", "catalyst" ] ], "additional_components": [ "Q9VF33", "FBgn0026616", "species_1562550", "Q24451", "FBgn0011740" ] }, "reaction_10455908": { "compartment": "compartment_17963", "id": "reaction_10455908", "reactome": "R-DME-975926", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981613" ], "modifiers": [ [ "species_10455905", "catalyst" ] ], "additional_components": [ "FBgn0051849" ] }, "reaction_10440636": { "compartment": "compartment_70101", "id": "reaction_10440636", "reactome": "R-DME-196350", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_29360" ], "products": [ "species_70106", "species_196344", "species_73473" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10440208": { "compartment": "compartment_70101", "id": "reaction_10440208", "reactome": "R-DME-193052", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196344" ], "products": [ "species_193055" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10493825": { "compartment": "compartment_7660", "id": "reaction_10493825", "reactome": "R-DME-8952058", "name": "CCND1 binds RUNX3 and displaces EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493737", "species_10457979" ], "products": [ "species_10493823", "species_10458126" ], "modifiers": [], "additional_components": [ "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "FBgn0010315", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "FBgn0261617" ] }, "reaction_10493829": { "compartment": "compartment_7660", "id": "reaction_10493829", "reactome": "R-DME-8952062", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493823", "species_10469978" ], "products": [ "species_10493827" ], "modifiers": [], "additional_components": [ "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "FBgn0041210", "M9PHQ2", "FBgn0041210", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656" ] }, "reaction_10493721": { "compartment": "compartment_7660", "id": "reaction_10493721", "reactome": "R-DME-8951966", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493708", "species_113560" ], "products": [ "species_2485002", "species_10493718" ], "modifiers": [ [ "species_10493708", "catalyst" ], [ "species_10437860", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10493834": { "compartment": "compartment_7660", "id": "reaction_10493834", "reactome": "R-DME-8952069", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10493827" ], "products": [ "species_427486", "species_10493735", "species_10493831" ], "modifiers": [ [ "species_10493827", "catalyst" ] ], "additional_components": [ "M9PHQ2", "FBgn0041210", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "Q7KUZ5", "FBgn0010315", "M9PHQ2", "FBgn0041210", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "M9PHQ2", "FBgn0041210", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656" ] }, "reaction_10493739": { "compartment": "compartment_7660", "id": "reaction_10493739", "reactome": "R-DME-8951977", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493735", "species_10493718" ], "products": [ "species_10493737" ], "modifiers": [ [ "species_206703", "catalyst" ] ], "additional_components": [ "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "P08646", "RAS85D", "species_29438" ] }, "reaction_10493710": { "compartment": "compartment_7660", "id": "reaction_10493710", "reactome": "R-DME-8951951", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489803", "species_10458126" ], "products": [ "species_10493708" ], "modifiers": [], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "FBgn0261617", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981" ] }, "reaction_10449032": { "compartment": "compartment_70101", "id": "reaction_10449032", "reactome": "R-DME-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429926" ], "products": [ "species_430042", "species_429925" ], "modifiers": [ [ "species_10449029", "catalyst" ] ], "additional_components": [ "FBgn0037372" ] }, "reaction_10478392": { "compartment": "compartment_70101", "id": "reaction_10478392", "reactome": "R-DME-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_430042" ], "products": [ "species_29372", "species_5694090" ], "modifiers": [ [ "species_10478389", "catalyst" ] ], "additional_components": [ "FBgn0034988" ] }, "reaction_10449126": { "compartment": "compartment_70101", "id": "reaction_10449126", "reactome": "R-DME-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429974" ], "products": [ "species_109402", "species_113578", "species_109395", "species_429926", "species_76577" ], "modifiers": [ [ "species_10449123", "catalyst" ] ], "additional_components": [ "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9XZ19", "FBgn0027524", "Q6NNB2", "FBgn0033376", "Q9VCH8", "FBgn0039117", "Q9W074", "FBgn0042712" ] }, "reaction_10492020": { "compartment": "compartment_7660", "id": "reaction_10492020", "reactome": "R-DME-8934735", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10491997" ], "products": [ "species_77502", "species_10492017" ], "modifiers": [ [ "species_10491997", "catalyst" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834" ] }, "reaction_10492022": { "compartment": "compartment_7660", "id": "reaction_10492022", "reactome": "R-DME-8934742", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467587", "species_10489794" ], "products": [ "species_10491997" ], "modifiers": [], "additional_components": [ "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834" ] }, "reaction_10492150": { "compartment": "compartment_7660", "id": "reaction_10492150", "reactome": "R-DME-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492130" ], "products": [ "species_77502", "species_10492147" ], "modifiers": [ [ "species_10492130", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10492198": { "compartment": "compartment_7660", "id": "reaction_10492198", "reactome": "R-DME-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492193" ], "products": [ "species_77502", "species_10492195" ], "modifiers": [ [ "species_10492193", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10492189": { "compartment": "compartment_7660", "id": "reaction_10492189", "reactome": "R-DME-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492184" ], "products": [ "species_77502", "species_10492186" ], "modifiers": [ [ "species_10492184", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10492159": { "compartment": "compartment_7660", "id": "reaction_10492159", "reactome": "R-DME-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492154" ], "products": [ "species_77502", "species_10492156" ], "modifiers": [ [ "species_10492154", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10468106": { "compartment": "compartment_70101", "id": "reaction_10468106", "reactome": "R-DME-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468104" ], "products": [ "species_29370", "species_10468092" ], "modifiers": [], "additional_components": [] }, "reaction_10468102": { "compartment": "compartment_70101", "id": "reaction_10468102", "reactome": "R-DME-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468092" ], "products": [ "species_10468094" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10468100": { "compartment": "compartment_70101", "id": "reaction_10468100", "reactome": "R-DME-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468094" ], "products": [ "species_10468098" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10430845": { "compartment": "compartment_70101", "id": "reaction_10430845", "reactome": "R-DME-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430513", "species_72617", "species_10430440", "species_10430457", "species_10430508" ], "products": [ "species_10430513", "species_72617", "species_10430440", "species_10430457", "species_10430508" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "FBgn0030719", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0030719", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10430519": { "compartment": "compartment_70101", "id": "reaction_10430519", "reactome": "R-DME-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430508" ], "products": [ "species_29372", "species_29370", "species_10430508" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10464559": { "compartment": "compartment_7660", "id": "reaction_10464559", "reactome": "R-DME-2032794", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464550", "species_10464555", "species_10464523" ], "products": [ "species_10464557" ], "modifiers": [], "additional_components": [ "FBgn0020388", "FBgn0021767", "Q9W3F4", "FBgn0021767", "Q45VV3", "yki", "Q9VTZ1", "FBgn0020388" ] }, "reaction_10490929": { "compartment": "compartment_7660", "id": "reaction_10490929", "reactome": "R-DME-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10464537" ], "products": [ "species_10490927" ], "modifiers": [], "additional_components": [ "P30052", "sd", "Q45VV3", "yki" ] }, "reaction_10490933": { "compartment": "compartment_7660", "id": "reaction_10490933", "reactome": "R-DME-8871265", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10464541" ], "products": [ "species_10490931" ], "modifiers": [], "additional_components": [ "P30052", "sd", "Q45VV3", "yki" ] }, "reaction_10464535": { "compartment": "compartment_7660", "id": "reaction_10464535", "reactome": "R-DME-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464531", "species_10458548" ], "products": [ "species_10464533" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_10490937": { "compartment": "compartment_7660", "id": "reaction_10490937", "reactome": "R-DME-8871266", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10464539" ], "products": [ "species_10490935" ], "modifiers": [], "additional_components": [ "P30052", "sd", "Q45VV3", "yki" ] }, "reaction_10464545": { "compartment": "compartment_7660", "id": "reaction_10464545", "reactome": "R-DME-2032781", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464531", "species_10464523" ], "products": [ "species_10464543" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_10440633": { "compartment": "compartment_70101", "id": "reaction_10440633", "reactome": "R-DME-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196095", "species_70106", "species_29364" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10440630", "catalyst" ] ], "additional_components": [ "FBgn0086254" ] }, "reaction_10433192": { "compartment": "compartment_5460", "id": "reaction_10433192", "reactome": "R-DME-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77313", "species_113521" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433202": { "compartment": "compartment_5460", "id": "reaction_10433202", "reactome": "R-DME-77319", "name": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77318" ], "products": [ "species_31649", "species_77313" ], "modifiers": [ [ "species_10433199", "catalyst" ] ], "additional_components": [ "Q9VDT1", "FBgn0038742" ] }, "reaction_10435438": { "compartment": "compartment_17951", "id": "reaction_10435438", "reactome": "R-DME-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141349" ], "products": [ "species_141327", "species_113575", "species_141350" ], "modifiers": [ [ "species_10435435", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VHN8", "FBgn0037606" ] }, "reaction_10435428": { "compartment": "compartment_17951", "id": "reaction_10435428", "reactome": "R-DME-141341", "name": "SMOX-3 oxidises SPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141342" ], "products": [ "species_141324", "species_113575", "species_141328" ], "modifiers": [ [ "species_10435425", "catalyst" ] ], "additional_components": [ "FBgn0036749" ] }, "reaction_10444066": { "compartment": "compartment_70101", "id": "reaction_10444066", "reactome": "R-DME-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10444061", "catalyst" ] ], "additional_components": [ "FBgn0038302" ] }, "reaction_10444064": { "compartment": "compartment_70101", "id": "reaction_10444064", "reactome": "R-DME-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10444061", "catalyst" ] ], "additional_components": [ "FBgn0038302" ] }, "reaction_10435440": { "compartment": "compartment_17951", "id": "reaction_10435440", "reactome": "R-DME-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141323" ], "products": [ "species_141324", "species_141327", "species_113575" ], "modifiers": [ [ "species_10435435", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VHN8", "FBgn0037606" ] }, "reaction_10454399": { "compartment": "compartment_70101", "id": "reaction_10454399", "reactome": "R-DME-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_29432", "species_893615" ], "modifiers": [ [ "species_10454393", "catalyst" ], [ "species_29502", "inhibitor" ], [ "species_8939576", "inhibitor" ] ], "additional_components": [ "Q8SXC2", "FBgn0037955", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10490481": { "compartment": "compartment_876", "id": "reaction_10490481", "reactome": "R-DME-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10490478", "catalyst" ] ], "additional_components": [ "Q8IQF3", "FBgn0052081", "Q9VLM3", "FBgn0032036", "Q9VT04", "FBgn0036007", "Q9VTD5", "FBgn0052079", "M9PEU1", "FBgn0263776", "Q9VTD7", "FBgn0036116", "M9PHT8", "FBgn0030817", "Q9VX84", "FBgn0030816", "Q4V5R4", "FBgn0033572", "Q9W056", "FBgn0035300", "Q7K2W3", "FBgn0033760" ] }, "reaction_10428730": { "compartment": "compartment_70101", "id": "reaction_10428730", "reactome": "R-DME-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10428727", "catalyst" ] ], "additional_components": [ "species_71185", "P20351", "FBgn0003965" ] }, "reaction_10428738": { "compartment": "compartment_70101", "id": "reaction_10428738", "reactome": "R-DME-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10428735", "catalyst" ] ], "additional_components": [ "FBgn0000337" ] }, "reaction_10426991": { "compartment": "compartment_70101", "id": "reaction_10426991", "reactome": "R-DME-68712", "name": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10426958" ], "products": [ "species_10426956", "species_10426989" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7JVY2", "FBgn0000996", "Q7JX41", "FBgn0033081", "FBgn0000996", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7JX41", "FBgn0033081" ] }, "reaction_10427212": { "compartment": "compartment_7660", "id": "reaction_10427212", "reactome": "R-DME-68826", "name": "Free CDT1 associates with CDC6:ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426944", "species_10427208" ], "products": [ "species_10427210" ], "modifiers": [], "additional_components": [ "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "FBgn0000996", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918" ] }, "reaction_10427206": { "compartment": "compartment_70101", "id": "reaction_10427206", "reactome": "R-DME-68825", "name": "Ubiquitinated geminin is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426989" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7JX41", "FBgn0033081", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10491189": { "compartment": "compartment_17927", "id": "reaction_10491189", "reactome": "R-DME-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10491186", "catalyst" ] ], "additional_components": [ "FBgn0037852" ] }, "reaction_10441188": { "compartment": "compartment_876", "id": "reaction_10441188", "reactome": "R-DME-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10441185", "catalyst" ] ], "additional_components": [ "Q9VGV5", "FBgn0037846", "Q9VK64", "FBgn0032449", "Q9VGV6", "FBgn0037845" ] }, "reaction_10440656": { "compartment": "compartment_70101", "id": "reaction_10440656", "reactome": "R-DME-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10440653", "catalyst" ] ], "additional_components": [ "Q8T4A5", "FBgn0037942", "species_29926" ] }, "reaction_10440685": { "compartment": "compartment_70101", "id": "reaction_10440685", "reactome": "R-DME-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73524" ], "products": [ "species_111294", "species_29386" ], "modifiers": [ [ "species_10440682", "catalyst" ] ], "additional_components": [ "FBgn0030431" ] }, "reaction_10467560": { "compartment": "compartment_70101", "id": "reaction_10467560", "reactome": "R-DME-3165230", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3165253" ], "products": [ "species_196931" ], "modifiers": [ [ "species_10467553", "catalyst" ], [ "species_73524", "inhibitor" ], [ "species_29386", "inhibitor" ] ], "additional_components": [ "FBgn0039882" ] }, "reaction_10440695": { "compartment": "compartment_70101", "id": "reaction_10440695", "reactome": "R-DME-196964", "name": "RFK:Mg2+ phosphorylates RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196931" ], "products": [ "species_29370", "species_73524" ], "modifiers": [ [ "species_10440692", "catalyst" ] ], "additional_components": [ "species_29926", "O76206", "FBgn0014930" ] }, "reaction_10455535": { "compartment": "compartment_70101", "id": "reaction_10455535", "reactome": "R-DME-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965053" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10455530", "catalyst" ] ], "additional_components": [ "species_1562550", "Q7KUC2", "FBgn0085484" ] }, "reaction_10455533": { "compartment": "compartment_70101", "id": "reaction_10455533", "reactome": "R-DME-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10455530", "catalyst" ] ], "additional_components": [ "species_1562550", "Q7KUC2", "FBgn0085484" ] }, "reaction_10455549": { "compartment": "compartment_70101", "id": "reaction_10455549", "reactome": "R-DME-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965146" ], "products": [ "species_29390", "species_31633", "species_29408" ], "modifiers": [ [ "species_10455544", "catalyst" ] ], "additional_components": [ "species_76629", "Q9VHZ5", "FBgn0051472" ] }, "reaction_10455547": { "compartment": "compartment_70101", "id": "reaction_10455547", "reactome": "R-DME-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_964952" ], "products": [ "species_29390", "species_29408" ], "modifiers": [ [ "species_10455544", "catalyst" ] ], "additional_components": [ "species_76629", "Q9VHZ5", "FBgn0051472" ] }, "reaction_10467575": { "compartment": "compartment_70101", "id": "reaction_10467575", "reactome": "R-DME-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10467572", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "species_113596", "P10351", "FBgn0003308" ] }, "reaction_10455537": { "compartment": "compartment_70101", "id": "reaction_10455537", "reactome": "R-DME-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965131" ], "products": [ "species_29390", "species_29370" ], "modifiers": [ [ "species_10455530", "catalyst" ] ], "additional_components": [ "species_1562550", "Q7KUC2", "FBgn0085484" ] }, "reaction_10467320": { "compartment": "compartment_876", "id": "reaction_10467320", "reactome": "R-DME-3000103", "name": "CUBN:AMN binds GIF:Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467316", "species_10443525" ], "products": [ "species_10467318" ], "modifiers": [], "additional_components": [ "species_3000239", "Q9W4K2", "FBgn0029708", "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467416": { "compartment": "compartment_70101", "id": "reaction_10467416", "reactome": "R-DME-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_3000241", "species_113592" ], "products": [ "species_29372", "species_29370", "species_3000125" ], "modifiers": [ [ "species_10443830", "catalyst" ] ], "additional_components": [ "FBgn0032456" ] }, "reaction_10467352": { "compartment": "compartment_161320", "id": "reaction_10467352", "reactome": "R-DME-3000263", "name": "TCII:Cbl is degraded to release Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467328" ], "products": [ "species_3000239" ], "modifiers": [], "additional_components": [ "Q9W4K2", "FBgn0029708", "species_3000239" ] }, "reaction_10467350": { "compartment": "compartment_17940", "id": "reaction_10467350", "reactome": "R-DME-3000247", "name": "Endosomal GIF:Cbl translocates to lysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467342" ], "products": [ "species_10467348" ], "modifiers": [], "additional_components": [ "species_3000239", "Q9W4K2", "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467332": { "compartment": "compartment_984", "id": "reaction_10467332", "reactome": "R-DME-3000120", "name": "GIF binds Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467314", "species_3000125" ], "products": [ "species_10467316" ], "modifiers": [], "additional_components": [ "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467507": { "compartment": "compartment_984", "id": "reaction_10467507", "reactome": "R-DME-3132759", "name": "TCN1 binds Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3132775", "species_10467503" ], "products": [ "species_10467505", "species_3132772" ], "modifiers": [], "additional_components": [ "species_3000239", "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467891": { "compartment": "compartment_984", "id": "reaction_10467891", "reactome": "R-DME-3245898", "name": "TCN1 binds Cbl in the circulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467503", "species_3000125" ], "products": [ "species_10467505" ], "modifiers": [], "additional_components": [ "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467330": { "compartment": "compartment_17940", "id": "reaction_10467330", "reactome": "R-DME-3000112", "name": "Endosomal TCII:Cbl translocates to lysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467324" ], "products": [ "species_10467328" ], "modifiers": [], "additional_components": [ "species_3000239", "Q9W4K2", "FBgn0029708", "Q9W4K2", "FBgn0029708", "species_3000239" ] }, "reaction_10467344": { "compartment": "compartment_984", "id": "reaction_10467344", "reactome": "R-DME-3000137", "name": "CUBN:AMN transports extracellular GIF:Cbl to endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467318" ], "products": [ "species_10467338", "species_10467342" ], "modifiers": [], "additional_components": [ "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "species_3000239", "Q9W4K2", "FBgn0029708", "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467312": { "compartment": "compartment_984", "id": "reaction_10467312", "reactome": "R-DME-3000074", "name": "TCII binds Cbl in the circulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467308", "species_3000125" ], "products": [ "species_10467310" ], "modifiers": [], "additional_components": [ "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10440735": { "compartment": "compartment_70101", "id": "reaction_10440735", "reactome": "R-DME-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_197256", "species_113592", "species_29472" ], "products": [ "species_111294", "species_29404", "species_76577", "species_29360" ], "modifiers": [ [ "species_10440732", "catalyst" ] ], "additional_components": [ "Q9VYA0", "FBgn0030512" ] }, "reaction_10441342": { "compartment": "compartment_5460", "id": "reaction_10441342", "reactome": "R-DME-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938078", "species_8938090" ], "modifiers": [ [ "species_10441339", "catalyst" ] ], "additional_components": [ "Q9VC03", "FBgn0039254", "species_29926" ] }, "reaction_10490435": { "compartment": "compartment_70101", "id": "reaction_10490435", "reactome": "R-DME-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10490432", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10490440": { "compartment": "compartment_70101", "id": "reaction_10490440", "reactome": "R-DME-8869607", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10490437", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10440725": { "compartment": "compartment_70101", "id": "reaction_10440725", "reactome": "R-DME-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10440722", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VC03", "FBgn0039254" ] }, "reaction_10490443": { "compartment": "compartment_70101", "id": "reaction_10490443", "reactome": "R-DME-8869627", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10490437", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10492619": { "compartment": "compartment_984", "id": "reaction_10492619", "reactome": "R-DME-8940070", "name": "NT5E:Zn2+ hydrolyses NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352330", "species_109276" ], "products": [ "species_109277", "species_8940067" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10492621": { "compartment": "compartment_984", "id": "reaction_10492621", "reactome": "R-DME-8940074", "name": "NT5E:Zn2+ hydrolyses NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8940067" ], "products": [ "species_109277", "species_8940077" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10490446": { "compartment": "compartment_70101", "id": "reaction_10490446", "reactome": "R-DME-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10490432", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10440715": { "compartment": "compartment_70101", "id": "reaction_10440715", "reactome": "R-DME-197198", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29360" ], "products": [ "species_29370", "species_29366" ], "modifiers": [ [ "species_10440712", "catalyst" ] ], "additional_components": [ "species_1562550", "Q6IDH2", "FBgn0033853" ] }, "reaction_10492564": { "compartment": "compartment_70101", "id": "reaction_10492564", "reactome": "R-DME-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10440722", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VC03", "FBgn0039254" ] }, "reaction_10486272": { "compartment": "compartment_5460", "id": "reaction_10486272", "reactome": "R-DME-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6807477" ], "products": [ "species_113548", "species_113581", "species_113529", "species_113600" ], "modifiers": [ [ "species_10486269", "catalyst" ] ], "additional_components": [ "FBgn0036848" ] }, "reaction_10492311": { "compartment": "compartment_70101", "id": "reaction_10492311", "reactome": "R-DME-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938276", "species_29360" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10492304", "catalyst" ] ], "additional_components": [ "FBgn0034129" ] }, "reaction_10486264": { "compartment": "compartment_5460", "id": "reaction_10486264", "reactome": "R-DME-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10486261", "catalyst" ] ], "additional_components": [ "Q9W2Y3", "FBgn0030178" ] }, "reaction_10490427": { "compartment": "compartment_876", "id": "reaction_10490427", "reactome": "R-DME-8869603", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869604" ], "products": [ "species_197230" ], "modifiers": [ [ "species_10490424", "catalyst" ] ], "additional_components": [ "FBgn0086365" ] }, "reaction_10440705": { "compartment": "compartment_70101", "id": "reaction_10440705", "reactome": "R-DME-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_197230", "species_70106" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10440702", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VQX4", "FBgn0031589" ] }, "reaction_10441349": { "compartment": "compartment_7660", "id": "reaction_10441349", "reactome": "R-DME-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200492", "species_29358" ], "products": [ "species_8878981", "species_200499" ], "modifiers": [ [ "species_10441346", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VC03", "FBgn0039254" ] }, "reaction_10440974": { "compartment": "compartment_876", "id": "reaction_10440974", "reactome": "R-DME-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10440971", "catalyst" ] ], "additional_components": [ "Q7KK97", "FBgn0028563", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562" ] }, "reaction_10441014": { "compartment": "compartment_70101", "id": "reaction_10441014", "reactome": "R-DME-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10441000" ], "products": [ "species_10440998", "species_198816" ], "modifiers": [ [ "species_10441000", "catalyst" ] ], "additional_components": [ "species_71185", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "CHEBI:36144", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "species_71185", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575" ] }, "reaction_10441011": { "compartment": "compartment_70101", "id": "reaction_10441011", "reactome": "R-DME-198824", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10440998", "species_73473" ], "products": [ "species_10441000", "species_29360" ], "modifiers": [ [ "species_10441008", "catalyst" ] ], "additional_components": [ "CHEBI:36144", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "species_71185", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "X2JGK6", "FBgn0036211", "species_113596" ] }, "reaction_10440945": { "compartment": "compartment_70101", "id": "reaction_10440945", "reactome": "R-DME-198813", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_198827" ], "products": [ "species_198816", "species_111745" ], "modifiers": [ [ "species_10440942", "catalyst" ] ], "additional_components": [ "Q9VSL6", "FBgn0035907", "Q9VSL5", "FBgn0035906", "Q9VSL3", "FBgn0086348", "Q9VSL2", "FBgn0035904" ] }, "reaction_10441024": { "compartment": "compartment_876", "id": "reaction_10441024", "reactome": "R-DME-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198836", "species_74113" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10441019", "catalyst" ] ], "additional_components": [ "FBgn0037807" ] }, "reaction_10441433": { "compartment": "compartment_70101", "id": "reaction_10441433", "reactome": "R-DME-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10441430", "catalyst" ] ], "additional_components": [ "Q9VTI0", "FBgn0036157" ] }, "reaction_10441362": { "compartment": "compartment_70101", "id": "reaction_10441362", "reactome": "R-DME-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10486575": { "compartment": "compartment_5460", "id": "reaction_10486575", "reactome": "R-DME-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_6808499", "species_113521" ], "products": [ "species_113529", "species_200679", "species_113600", "species_29376" ], "modifiers": [ [ "species_10486572", "catalyst" ] ], "additional_components": [ "Q9VIC9", "FBgn0032945" ] }, "reaction_10441423": { "compartment": "compartment_70101", "id": "reaction_10441423", "reactome": "R-DME-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_29356", "species_200640" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441420": { "compartment": "compartment_876", "id": "reaction_10441420", "reactome": "R-DME-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10441417", "catalyst" ] ], "additional_components": [ "Q9VK64", "FBgn0032449", "Q9VGV6", "FBgn0037845", "Q9VGV5", "FBgn0037846" ] }, "reaction_10479244": { "compartment": "compartment_5460", "id": "reaction_10479244", "reactome": "R-DME-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801451", "species_200671", "species_113593" ], "products": [ "species_113548", "species_113581", "species_5389850" ], "modifiers": [ [ "species_10479241", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10486583": { "compartment": "compartment_70101", "id": "reaction_10486583", "reactome": "R-DME-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10486580", "catalyst" ] ], "additional_components": [ "Q9VIC9", "FBgn0032945" ] }, "reaction_10485817": { "compartment": "compartment_5460", "id": "reaction_10485817", "reactome": "R-DME-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_5693984" ], "products": [ "species_6801458", "species_29362" ], "modifiers": [ [ "species_10485812", "catalyst" ] ], "additional_components": [ "FBgn0010222" ] }, "reaction_10441409": { "compartment": "compartment_70101", "id": "reaction_10441409", "reactome": "R-DME-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10428758", "catalyst" ] ], "additional_components": [ "Q9W457", "FBgn0029823" ] }, "reaction_10441407": { "compartment": "compartment_876", "id": "reaction_10441407", "reactome": "R-DME-200646", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965" ], "products": [ "species_200716" ], "modifiers": [ [ "species_10441404", "catalyst" ] ], "additional_components": [ "B7YZU3", "FBgn0033387", "Q8INF8", "FBgn0051321", "Q9VY22", "FBgn0030576", "A1Z7R6", "FBgn0033388", "Q1EC10", "FBgn0050345", "Q9VA14", "FBgn0039817", "Q0E8E1", "FBgn0260388", "Q961H2", "FBgn0050344" ] }, "reaction_10485825": { "compartment": "compartment_70101", "id": "reaction_10485825", "reactome": "R-DME-6801342", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803257", "species_113592" ], "products": [ "species_29372", "species_70106", "species_29370", "species_200640" ], "modifiers": [ [ "species_10485822", "catalyst" ] ], "additional_components": [ "FBgn0085453" ] }, "reaction_10485827": { "compartment": "compartment_5460", "id": "reaction_10485827", "reactome": "R-DME-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_5389850" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10479241", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10485830": { "compartment": "compartment_5460", "id": "reaction_10485830", "reactome": "R-DME-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801458", "species_113521" ], "products": [ "species_5389850" ], "modifiers": [ [ "species_10485812", "catalyst" ] ], "additional_components": [ "FBgn0010222" ] }, "reaction_10441461": { "compartment": "compartment_70101", "id": "reaction_10441461", "reactome": "R-DME-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_200640" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441459": { "compartment": "compartment_70101", "id": "reaction_10441459", "reactome": "R-DME-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10428758", "catalyst" ] ], "additional_components": [ "Q9W457", "FBgn0029823" ] }, "reaction_10441457": { "compartment": "compartment_876", "id": "reaction_10441457", "reactome": "R-DME-200729", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200716" ], "products": [ "species_197965" ], "modifiers": [ [ "species_10441404", "catalyst" ] ], "additional_components": [ "B7YZU3", "FBgn0033387", "Q8INF8", "FBgn0051321", "Q9VY22", "FBgn0030576", "A1Z7R6", "FBgn0033388", "Q1EC10", "FBgn0050345", "Q9VA14", "FBgn0039817", "Q0E8E1", "FBgn0260388", "Q961H2", "FBgn0050344" ] }, "reaction_10440753": { "compartment": "compartment_70101", "id": "reaction_10440753", "reactome": "R-DME-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73604", "species_29364" ], "products": [ "species_111355", "species_29366" ], "modifiers": [ [ "species_10440748", "catalyst" ] ], "additional_components": [ "FBgn0004087" ] }, "reaction_10440751": { "compartment": "compartment_70101", "id": "reaction_10440751", "reactome": "R-DME-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10440748", "catalyst" ] ], "additional_components": [ "FBgn0004087" ] }, "reaction_10441455": { "compartment": "compartment_70616", "id": "reaction_10441455", "reactome": "R-DME-200720", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671" ], "products": [ "species_111355" ], "modifiers": [ [ "species_10441438", "catalyst" ] ], "additional_components": [ "FBgn0033391" ] }, "reaction_10441453": { "compartment": "compartment_70101", "id": "reaction_10441453", "reactome": "R-DME-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441451": { "compartment": "compartment_70101", "id": "reaction_10441451", "reactome": "R-DME-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29372", "species_29370", "species_111353" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441448": { "compartment": "compartment_5460", "id": "reaction_10441448", "reactome": "R-DME-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_113593", "species_113552" ], "products": [ "species_113548", "species_113581", "species_200679" ], "modifiers": [ [ "species_10441445", "catalyst" ] ], "additional_components": [ "FBgn0030407" ] }, "reaction_10440743": { "compartment": "compartment_70101", "id": "reaction_10440743", "reactome": "R-DME-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111355", "species_113592" ], "products": [ "species_29372", "species_29370", "species_197969" ], "modifiers": [ [ "species_10440740", "catalyst" ] ], "additional_components": [ "FBgn0030407" ] }, "reaction_10441443": { "compartment": "compartment_70101", "id": "reaction_10441443", "reactome": "R-DME-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_200665", "species_113592" ], "products": [ "species_29372", "species_29370", "species_174404" ], "modifiers": [ [ "species_10440740", "catalyst" ] ], "additional_components": [ "FBgn0030407" ] }, "reaction_10498781": { "compartment": "compartment_70101", "id": "reaction_10498781", "reactome": "R-DME-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10498778", "catalyst" ] ], "additional_components": [ "P17719", "FBgn0004087" ] }, "reaction_10469673": { "compartment": "compartment_5460", "id": "reaction_10469673", "reactome": "R-DME-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3065953" ], "products": [ "species_29582", "species_29444" ], "modifiers": [ [ "species_10469670", "catalyst" ] ], "additional_components": [ "FBgn0040069" ] }, "reaction_10468376": { "compartment": "compartment_70101", "id": "reaction_10468376", "reactome": "R-DME-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468374" ], "products": [ "species_10467405" ], "modifiers": [], "additional_components": [ "Q0E9E2", "FBgn0027580", "species_266099", "Q9V9T5", "FBgn0039877", "Q9V9A7", "FBgn0042083", "Q0E9E2", "FBgn0027580", "species_266099", "Q9V9T5", "FBgn0039877", "Q9V9A7", "FBgn0042083" ] }, "reaction_10467413": { "compartment": "compartment_984", "id": "reaction_10467413", "reactome": "R-DME-3076905", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3076887" ], "products": [ "species_199238", "species_351991" ], "modifiers": [ [ "species_10467410", "catalyst" ] ], "additional_components": [ "FBgn0040069" ] }, "reaction_10441069": { "compartment": "compartment_70101", "id": "reaction_10441069", "reactome": "R-DME-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441061", "species_76194" ], "products": [ "species_10432485", "species_158466" ], "modifiers": [ [ "species_10441066", "catalyst" ] ], "additional_components": [ "FBgn0283427", "FBgn0283427", "FBgn0052099" ] }, "reaction_10440669": { "compartment": "compartment_70101", "id": "reaction_10440669", "reactome": "R-DME-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10440666", "catalyst" ] ], "additional_components": [ "species_76629", "Q8MKK3", "FBgn0050290" ] }, "reaction_10440646": { "compartment": "compartment_70101", "id": "reaction_10440646", "reactome": "R-DME-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_111294", "species_196778" ], "modifiers": [ [ "species_10440643", "catalyst" ] ], "additional_components": [ "FBgn0035632" ] }, "reaction_10440677": { "compartment": "compartment_70101", "id": "reaction_10440677", "reactome": "R-DME-196857", "name": "PANK2 phosphorylates PanK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196820" ], "products": [ "species_29370", "species_196786" ], "modifiers": [ [ "species_10440674", "catalyst" ] ], "additional_components": [ "FBgn0011205" ] }, "reaction_10441076": { "compartment": "compartment_70101", "id": "reaction_10441076", "reactome": "R-DME-199203", "name": "PANK1/3/4 phosphorylate PanK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196820" ], "products": [ "species_29370", "species_196786" ], "modifiers": [ [ "species_10441071", "catalyst" ] ], "additional_components": [ "FBgn0011205" ] }, "reaction_10440659": { "compartment": "compartment_70101", "id": "reaction_10440659", "reactome": "R-DME-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_29370", "species_76194" ], "modifiers": [ [ "species_10440643", "catalyst" ] ], "additional_components": [ "FBgn0035632" ] }, "reaction_10455438": { "compartment": "compartment_70101", "id": "reaction_10455438", "reactome": "R-DME-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947561", "species_947496" ], "products": [ "species_111294", "species_947539", "species_76577" ], "modifiers": [ [ "species_10455435", "catalyst" ] ], "additional_components": [ "species_29926", "P39205", "FBgn0000316" ] }, "reaction_10455403": { "compartment": "compartment_70101", "id": "reaction_10455403", "reactome": "R-DME-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10455400", "catalyst" ] ], "additional_components": [ "FBgn0002641" ] }, "reaction_10455450": { "compartment": "compartment_70101", "id": "reaction_10455450", "reactome": "R-DME-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356", "species_71284" ], "products": [ "species_111294", "species_947537", "species_947703", "species_174390" ], "modifiers": [ [ "species_10455447", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q8IQF1", "FBgn0263241" ] }, "reaction_10455426": { "compartment": "compartment_70101", "id": "reaction_10455426", "reactome": "R-DME-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455410", "species_111707" ], "products": [ "species_10455415", "species_29432" ], "modifiers": [ [ "species_10455423", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VLJ8", "FBgn0032054", "species_1562550", "Q9VLJ8", "FBgn0032054", "Q9VKD3", "FBgn0032393" ] }, "reaction_10497008": { "compartment": "compartment_12045", "id": "reaction_10497008", "reactome": "R-DME-9026967", "name": "VKORC1 inhibitors binds VKORC1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435910", "species_9035082" ], "products": [ "species_10435913" ], "modifiers": [], "additional_components": [ "A1ZAJ5", "FBgn0053544", "A1ZAJ5", "FBgn0053544" ] }, "reaction_10486243": { "compartment": "compartment_17957", "id": "reaction_10486243", "reactome": "R-DME-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806362", "species_6806656" ], "modifiers": [ [ "species_10486240", "catalyst" ] ], "additional_components": [ "FBgn0028375" ] }, "reaction_10435915": { "compartment": "compartment_12045", "id": "reaction_10435915", "reactome": "R-DME-159790", "name": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_6806366" ], "products": [ "species_6806362" ], "modifiers": [ [ "species_10435910", "catalyst" ], [ "species_10435913", "inhibitor" ] ], "additional_components": [ "A1ZAJ5", "FBgn0053544", "A1ZAJ5", "FBgn0053544" ] }, "reaction_10486235": { "compartment": "compartment_17957", "id": "reaction_10486235", "reactome": "R-DME-6806647", "name": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_6806366" ], "products": [ "species_6806362" ], "modifiers": [ [ "species_10486232", "catalyst" ] ], "additional_components": [ "FBgn0053544" ] }, "reaction_10455791": { "compartment": "compartment_70101", "id": "reaction_10455791", "reactome": "R-DME-975635", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_975643" ], "products": [ "species_975622" ], "modifiers": [ [ "species_10455788", "catalyst" ] ], "additional_components": [ "Q9VFS2", "FBgn0002937", "species_111793" ] }, "reaction_10465678": { "compartment": "compartment_70101", "id": "reaction_10465678", "reactome": "R-DME-2404142", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431845", "species_2473616" ], "products": [ "species_10465676" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_2473604", "Q8INK3", "FBgn0037913" ] }, "reaction_10455773": { "compartment": "compartment_984", "id": "reaction_10455773", "reactome": "R-DME-975594", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_975591" ], "products": [ "species_975590", "species_426576" ], "modifiers": [ [ "species_10455770", "catalyst" ] ], "additional_components": [ "FBgn0036939" ] }, "reaction_10465674": { "compartment": "compartment_70101", "id": "reaction_10465674", "reactome": "R-DME-2399913", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_10455775" ], "products": [ "species_10455779" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_975622" ] }, "reaction_10467095": { "compartment": "compartment_70101", "id": "reaction_10467095", "reactome": "R-DME-2855259", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473610", "species_10431845" ], "products": [ "species_10465680" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_2473604" ] }, "reaction_10455781": { "compartment": "compartment_70101", "id": "reaction_10455781", "reactome": "R-DME-975633", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975590", "species_10455775" ], "products": [ "species_10455777" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_2473604" ] }, "reaction_10467093": { "compartment": "compartment_70101", "id": "reaction_10467093", "reactome": "R-DME-2855252", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455779", "species_70106", "species_29364" ], "products": [ "species_10455777", "species_29366" ], "modifiers": [ [ "species_10467090", "catalyst" ] ], "additional_components": [ "Q8INK3", "FBgn0037913", "species_975622", "Q8INK3", "FBgn0037913", "species_2473604", "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10470451": { "compartment": "compartment_5460", "id": "reaction_10470451", "reactome": "R-DME-5164399", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_5164389" ], "products": [ "species_5164390", "species_5164383" ], "modifiers": [ [ "species_10470448", "catalyst" ] ], "additional_components": [ "Q9VFS2", "FBgn0002937", "species_111793" ] }, "reaction_10465682": { "compartment": "compartment_70101", "id": "reaction_10465682", "reactome": "R-DME-2404144", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465680" ], "products": [ "species_10431845", "species_2473616" ], "modifiers": [], "additional_components": [ "Q8INK3", "FBgn0037913", "species_2473604", "FBgn0037913" ] }, "reaction_10491072": { "compartment": "compartment_70101", "id": "reaction_10491072", "reactome": "R-DME-8874705", "name": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491068" ], "products": [ "species_10491070" ], "modifiers": [], "additional_components": [ "species_8874708", "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783", "species_8874708", "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783" ] }, "reaction_10491074": { "compartment": "compartment_70101", "id": "reaction_10491074", "reactome": "R-DME-8874718", "name": "TTPA binds alpha-TOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491066", "species_8874708" ], "products": [ "species_10491068" ], "modifiers": [], "additional_components": [ "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783", "species_8874708", "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783" ] }, "reaction_10459358": { "compartment": "compartment_70101", "id": "reaction_10459358", "reactome": "R-DME-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10459355", "catalyst" ] ], "additional_components": [ "species_1562550", "P48611", "FBgn0003141" ] }, "reaction_10459534": { "compartment": "compartment_70101", "id": "reaction_10459534", "reactome": "R-DME-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474179", "species_29364" ], "products": [ "species_29870", "species_29366" ], "modifiers": [ [ "species_10459531", "catalyst" ] ], "additional_components": [ "O76752", "FBgn0014032" ] }, "reaction_10459879": { "compartment": "compartment_70101", "id": "reaction_10459879", "reactome": "R-DME-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441857", "species_1497857" ], "products": [ "species_29870", "species_10459877" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "species_1497857", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10459347": { "compartment": "compartment_70101", "id": "reaction_10459347", "reactome": "R-DME-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10459344", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "P48596", "FBgn0003162" ] }, "reaction_10459555": { "compartment": "compartment_70101", "id": "reaction_10459555", "reactome": "R-DME-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459538", "species_113592" ], "products": [ "species_29370", "species_10459355" ], "modifiers": [ [ "species_10459552", "catalyst" ] ], "additional_components": [ "P48611", "FBgn0003141", "species_1562550", "P48611", "FBgn0003141", "Q9VL34", "FBgn0032187", "Q03043", "FBgn0000721", "Q03042", "FBgn0000442" ] }, "reaction_10459890": { "compartment": "compartment_70101", "id": "reaction_10459890", "reactome": "R-DME-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1497811", "species_29364" ], "products": [ "species_1497857", "species_29366" ], "modifiers": [ [ "species_10459531", "catalyst" ] ], "additional_components": [ "O76752", "FBgn0014032" ] }, "reaction_10459888": { "compartment": "compartment_70101", "id": "reaction_10459888", "reactome": "R-DME-1497853", "name": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10459886" ], "products": [ "species_29370", "species_10459531" ], "modifiers": [ [ "species_10459552", "catalyst" ] ], "additional_components": [ "O76752", "FBgn0014032", "O76752", "FBgn0014032", "Q9VL34", "FBgn0032187", "Q03043", "FBgn0000721", "Q03042", "FBgn0000442" ] }, "reaction_10446462": { "compartment": "compartment_17951", "id": "reaction_10446462", "reactome": "R-DME-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389548", "species_389556" ], "products": [ "species_193465", "species_389536", "species_389537", "species_113602" ], "modifiers": [ [ "species_10446459", "catalyst" ] ], "additional_components": [ "B7Z0E0", "FBgn0001248" ] }, "reaction_10465151": { "compartment": "compartment_5460", "id": "reaction_10465151", "reactome": "R-DME-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162209" ], "products": [ "species_2162252", "species_113529", "species_2162215" ], "modifiers": [ [ "species_10465137", "catalyst" ] ], "additional_components": [ "FBgn0032922" ] }, "reaction_10465148": { "compartment": "compartment_70616", "id": "reaction_10465148", "reactome": "R-DME-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10465145", "catalyst" ] ], "additional_components": [ "FBgn0037574" ] }, "reaction_10465174": { "compartment": "compartment_5460", "id": "reaction_10465174", "reactome": "R-DME-2162253", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162257", "species_2162256" ], "products": [ "species_159450", "species_2162214" ], "modifiers": [ [ "species_10465171", "catalyst" ] ], "additional_components": [ "Q9V9Z3", "FBgn0051005", "species_29926", "Q9VP87", "FBgn0037044" ] }, "reaction_10465140": { "compartment": "compartment_5460", "id": "reaction_10465140", "reactome": "R-DME-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162212" ], "products": [ "species_2162252", "species_113529", "species_2162198" ], "modifiers": [ [ "species_10465137", "catalyst" ] ], "additional_components": [ "FBgn0032922" ] }, "reaction_216133": { "compartment": "compartment_70101", "id": "reaction_216133", "reactome": "R-DME-216133", "name": "Dissociation of CI from COS", "reversible": "false", "notes": "Coastal2 (COS) phosphorylated on Ser572 has reduced affinity for Cubitus Interruptus (CI). This may contribute to partial dissociation of CI from COS complexes.", "reactants": [ "species_206734" ], "products": [ "species_206046", "species_206634" ], "modifiers": [], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P91682", "phospho-smo" ] }, "reaction_209220": { "compartment": "compartment_70101", "id": "reaction_209220", "reactome": "R-DME-209220", "name": "Liberation of CI from SU(FU) repression", "reversible": "false", "notes": "Cubitus Interruptus (CI) that is spared from proteolysis is liberated from the repressive effects of its direct binding partner, Supressor of Fused (SU(FU)), by Fused (FU) Ser/Thr kinase activity. FU is believed to phosphorylate SU(FU) but it is not known if this relieves repression.", "reactants": [ "species_113592", "species_206634", "species_206802" ], "products": [ "species_205950", "species_206046", "species_29370", "species_206634" ], "modifiers": [ [ "species_205872", "catalyst" ] ], "additional_components": [ "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P91682", "phospho-smo", "Q27279", "Phospho SU(FU)", "P19538", "ci", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P91682", "phospho-smo" ] }, "reaction_209163": { "compartment": "compartment_13231", "id": "reaction_209163", "reactome": "R-DME-209163", "name": "CI transports from the cytosol to the nucleus", "reversible": "false", "notes": "Cubitus Interruptus (CI) access to the nucleus increases in response to Hedgehog signalling, most likely due to reduced cytoplasmic tethering by both Coastal2 (COS) and Suppressor of Fused (SU(FU)) complexes. However, the vast majority of CI is cytoplasmic.", "reactants": [ "species_206046" ], "products": [ "species_205911" ], "modifiers": [], "additional_components": [] }, "reaction_209215": { "compartment": "compartment_7660", "id": "reaction_209215", "reactome": "R-DME-209215", "name": "CI activates transcription", "reversible": "false", "notes": "Cubitus Interruptus (CI) activates transcription of ptc and several tissue-specific target genes that include direct CI binding sites in their regulatory sequences. CREB binding protein, CBP (NEJ) co-activator contributes to transcriptional activation.", "reactants": [ "species_205911" ], "products": [ "species_205911" ], "modifiers": [], "additional_components": [] }, "reaction_209178": { "compartment": "compartment_876", "id": "reaction_209178", "reactome": "R-DME-209178", "name": "N-HH binds to PTC receptor complex", "reversible": "false", "notes": "N-HH bound to Dally-like protein (DLP) is presented to Patched (PTC) receptor and Induced Hedgehog/Brother of Induced Hedgehog (IHOG/BOI) co-receptor to form a ternary complex at the plasma membrane. N-HH binds directly to PTC. Binding is enhanced by the putative co-receptor, IHOG/BOI, which is a type I transmembrane protein that can bind N-HH directly in the presence of Heparin. Signal transduction is also enhanced by DLP, implying that heparan sulphate proteoglycan (HSPG)-associated N-HH may be the most potent form of Hedgehog. Binding of N-HH to PTC leads to PTC internalisation and lysosomal degradation, resulting in a reduction of extracellular N-HH levels and a relief of repression of Smoothened (SMO) by PTC, which depends on the opposing actions of free PTC and N-HH bound PTC.", "reactants": [ "species_216284", "species_206021", "species_216135" ], "products": [ "species_216226" ], "modifiers": [], "additional_components": [ "Q02936", "hh", "Q9GPL5", "DLP", "Q9VM64", "ihog", "Q9W4Y6", "BOI", "Q02936", "hh", "Q9VM64", "ihog", "Q9W4Y6", "BOI", "P18502", "ptc", "Q9GPL5", "DLP" ] }, "reaction_216222": { "compartment": "compartment_70101", "id": "reaction_216222", "reactome": "R-DME-216222", "name": "COS binds to SMO", "reversible": "false", "notes": "SMO:COS:FU:CI complexes are present prior to Hedgehog signalling owing to direct binding of Smoothened (SMO) to both Coastal2 (COS) and the Ser/Thr kinase Fused (FU).", "reactants": [ "species_216188", "species_206086" ], "products": [ "species_216146" ], "modifiers": [], "additional_components": [ "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_209253": { "compartment": "compartment_70101", "id": "reaction_209253", "reactome": "R-DME-209253", "name": "Autophosphorylated FU phosphorylates COS", "reversible": "false", "notes": "The Ser/Thr protein kinase, Fused (FU), is capable of autophosphorylation and is proposed to be activated by phosphorylation on at least Thr158 and probably on other residues too. Costal2 (COS), bound to the phosphorylated transmembrane receptor Smoothened (SMO), is itself phosphorylated by FU at Ser572 and Ser931. Both FU and COS promote phosphorylation of SMO and its accumulation at the plasma membrane resulting in a positive feedback loop.", "reactants": [ "species_216158", "species_113592" ], "products": [ "species_206734", "species_29370" ], "modifiers": [ [ "species_205872", "catalyst" ] ], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_216202": { "compartment": "compartment_876", "id": "reaction_216202", "reactome": "R-DME-216202", "name": "Phosphorylated SMO changes conformation and is activated", "reversible": "false", "notes": "The Smoothened (SMO) large terminal cytoplasmic domain changes conformation in response to phosphorylation and becomes active. The localisation of SMO and its partners shifts from internal vesicles towards the plasma membrane. SMO stability increases results in the SMO:COS:FU:CI complexes at the plasma membrane becoming more abundant.Activation of SMO leads to reduced association of the Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase 1 alpha (CKIalpha), and Casein kinase I epsilon (DCO) with Costal2 (COS). This leads to a reduced phosphorylation of Cubitus Interruptus (CI) and inhibition of CI proteolysis and processing. This increases full-length CI protein levels.", "reactants": [ "species_206727" ], "products": [ "species_216158" ], "modifiers": [], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_209168": { "compartment": "compartment_70101", "id": "reaction_209168", "reactome": "R-DME-209168", "name": "Phosphorylation of SMO by CKIalpha", "reversible": "false", "notes": "Priming phosphorylation of the transmembrane protein Smoothened (SMO) leads to additional phosphorylation by Casein kinase I alpha (CKIalpha) at Ser670, Ser673, Ser690, Ser693, Ser743, and Ser746. Even though SMO has been shown to be explicitly phosphorylated by CKIalpha, phosphorylation of these residues by other CK1 isoforms cannot be ruled out. In addition, other residues are probably phosphorylated by unidentified kinases.", "reactants": [ "species_216105", "species_113592" ], "products": [ "species_29370", "species_206727" ], "modifiers": [ [ "species_206666", "catalyst" ] ], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209341": { "compartment": "compartment_70101", "id": "reaction_209341", "reactome": "R-DME-209341", "name": "Phosphorylation of SMO by PKA-C1", "reversible": "false", "notes": "The Ser/Thr kinase, Protein kinase A (PKA-C1) carries out priming phosphorylation of the transmembrane protein Smoothened (SMO) at Ser667, Ser687, and Ser740.", "reactants": [ "species_113592", "species_216146" ], "products": [ "species_29370", "species_216105" ], "modifiers": [ [ "species_206865", "catalyst" ] ], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "Q24170", "Phospho KSR", "P11346", "Raf", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "Q7KNQ9", "cnk", "Q8ML92", "AVE", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10458816": { "compartment": "compartment_876", "id": "reaction_10458816", "reactome": "R-DME-1296127", "name": "Activation of voltage gated Potassium channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458813", "catalyst" ] ], "additional_components": [ "M9PHI0", "FBgn0263220", "P17972", "FBgn0003386", "A8DYR5", "FBgn0085395", "Q7JPB9", "FBgn0003353", "P17970", "FBgn0262593", "Q02280", "FBgn0000535", "A1ZB14", "FBgn0011589", "P17971", "FBgn0005564", "A1Z856", "FBgn0033494", "P08510", "FBgn0003380" ] }, "reaction_10451102": { "compartment": "compartment_7660", "id": "reaction_10451102", "reactome": "R-DME-450550", "name": "PKCalpha phosphorylates HuR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10429721" ], "products": [ "species_113582", "species_10450960" ], "modifiers": [ [ "species_10451099", "catalyst" ] ], "additional_components": [ "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "FBgn0003091" ] }, "reaction_10451085": { "compartment": "compartment_7660", "id": "reaction_10451085", "reactome": "R-DME-450494", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429721", "species_450613" ], "products": [ "species_10450946" ], "modifiers": [], "additional_components": [ "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400" ] }, "reaction_10451097": { "compartment": "compartment_7660", "id": "reaction_10451097", "reactome": "R-DME-450533", "name": "PKCdelta phosphorylates HuR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10429721" ], "products": [ "species_113582", "species_10450973" ], "modifiers": [ [ "species_10451094", "catalyst" ] ], "additional_components": [ "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "FBgn0259680" ] }, "reaction_10450981": { "compartment": "compartment_7660", "id": "reaction_10450981", "reactome": "R-DME-450387", "name": "HuR binds the CRM1 nuclear export machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450944", "species_10450977", "species_10450932", "species_10450937", "species_10450939", "species_10437629" ], "products": [ "species_10450979" ], "modifiers": [], "additional_components": [ "FBgn0014879", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "FBgn0033483", "FBgn0034282", "FBgn0010660", "FBgn0020497", "Q9TVM2", "FBgn0020497", "Q9W1X4", "FBgn0010660", "Q9V895", "FBgn0034282", "Q8MUJ1", "FBgn0033483", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "P53997", "FBgn0014879" ] }, "reaction_10453156": { "compartment": "compartment_7660", "id": "reaction_10453156", "reactome": "R-DME-517705", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450973", "species_517622" ], "products": [ "species_10450975" ], "modifiers": [], "additional_components": [ "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263" ] }, "reaction_10453154": { "compartment": "compartment_7660", "id": "reaction_10453154", "reactome": "R-DME-517674", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450960", "species_450605" ], "products": [ "species_10450962" ], "modifiers": [], "additional_components": [ "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263" ] }, "reaction_10451200": { "compartment": "compartment_7660", "id": "reaction_10451200", "reactome": "R-DME-450595", "name": "HuR:mRNA complex translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450979" ], "products": [ "species_10451164", "species_10451198" ], "modifiers": [], "additional_components": [ "Q9TVM2", "FBgn0020497", "Q9W1X4", "FBgn0010660", "Q9V895", "FBgn0034282", "Q8MUJ1", "FBgn0033483", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "P53997", "FBgn0014879", "FBgn0033483", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263" ] }, "reaction_10451005": { "compartment": "compartment_70101", "id": "reaction_10451005", "reactome": "R-DME-450400", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451001", "species_10450986", "species_450597" ], "products": [ "species_10451003" ], "modifiers": [], "additional_components": [ "FBgn0011837", "FBgn0024921", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837" ] }, "reaction_10451052": { "compartment": "compartment_70101", "id": "reaction_10451052", "reactome": "R-DME-450463", "name": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451003" ], "products": [ "species_10450995", "species_29370" ], "modifiers": [ [ "species_10439416", "catalyst" ] ], "additional_components": [ "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "FBgn0013987" ] }, "reaction_10451031": { "compartment": "compartment_70101", "id": "reaction_10451031", "reactome": "R-DME-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448993", "species_10451027", "species_10449000", "species_10451003", "species_10449102" ], "products": [ "species_10451029" ], "modifiers": [], "additional_components": [ "FBgn0034921", "FBgn0020261", "FBgn0036534", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "Q5U127", "FBgn0036534", "E1JJR3", "FBgn0020261", "Q9W1H5", "FBgn0034921" ] }, "reaction_10450999": { "compartment": "compartment_70101", "id": "reaction_10450999", "reactome": "R-DME-450394", "name": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450995", "species_10432008" ], "products": [ "species_10450997" ], "modifiers": [], "additional_components": [ "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "P29310", "14-3-3zeta", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837" ] }, "reaction_10453023": { "compartment": "compartment_70101", "id": "reaction_10453023", "reactome": "R-DME-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451075", "species_10432008" ], "products": [ "species_10453021" ], "modifiers": [], "additional_components": [ "P47980", "FBgn0011837", "P29310", "14-3-3zeta", "P47980", "FBgn0011837" ] }, "reaction_10451083": { "compartment": "compartment_70101", "id": "reaction_10451083", "reactome": "R-DME-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451069" ], "products": [ "species_10451011", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "P47980", "FBgn0011837", "P47980", "FBgn0011837" ] }, "reaction_10451081": { "compartment": "compartment_70101", "id": "reaction_10451081", "reactome": "R-DME-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448993", "species_10451027", "species_10449000", "species_10451069", "species_10449102" ], "products": [ "species_10451079" ], "modifiers": [], "additional_components": [ "FBgn0034921", "FBgn0020261", "FBgn0036534", "P47980", "FBgn0011837", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "P47980", "FBgn0011837", "Q5U127", "FBgn0036534", "E1JJR3", "FBgn0020261", "Q9W1H5", "FBgn0034921" ] }, "reaction_10451015": { "compartment": "compartment_70101", "id": "reaction_10451015", "reactome": "R-DME-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451011", "species_10432008" ], "products": [ "species_10451013" ], "modifiers": [], "additional_components": [ "P47980", "FBgn0011837", "P29310", "14-3-3zeta", "P47980", "FBgn0011837" ] }, "reaction_10451077": { "compartment": "compartment_70101", "id": "reaction_10451077", "reactome": "R-DME-450474", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451069" ], "products": [ "species_10451075", "species_29370" ], "modifiers": [ [ "species_10439416", "catalyst" ] ], "additional_components": [ "P47980", "FBgn0011837", "P47980", "FBgn0011837", "FBgn0013987" ] }, "reaction_10451092": { "compartment": "compartment_70101", "id": "reaction_10451092", "reactome": "R-DME-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10451067" ], "products": [ "species_10451069" ], "modifiers": [], "additional_components": [ "FBgn0011837", "P47980", "FBgn0011837" ] }, "reaction_10451049": { "compartment": "compartment_70101", "id": "reaction_10451049", "reactome": "R-DME-450434", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451043", "species_450444" ], "products": [ "species_10451047" ], "modifiers": [], "additional_components": [ "Q08473", "FBgn0263396", "Q08473", "FBgn0263396" ] }, "reaction_10451065": { "compartment": "compartment_70101", "id": "reaction_10451065", "reactome": "R-DME-450466", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451063" ], "products": [], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q08473", "FBgn0263396", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10451160": { "compartment": "compartment_70101", "id": "reaction_10451160", "reactome": "R-DME-450580", "name": "AUF1 (hnRNP D0) is ubiquitinylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451156", "species_10426987" ], "products": [ "species_10451063" ], "modifiers": [], "additional_components": [ "P21187", "FBgn0265297", "P11147", "FBgn0266599", "Q08473", "FBgn0263396", "Q8IQW5", "FBgn0031037", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08473", "FBgn0263396" ] }, "reaction_10451158": { "compartment": "compartment_70101", "id": "reaction_10451158", "reactome": "R-DME-450551", "name": "AUF1 binds translation and heat shock proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430497", "species_10451154", "species_10451107", "species_10451047", "species_10447995", "species_10435551" ], "products": [ "species_10451156" ], "modifiers": [], "additional_components": [ "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "FBgn0031037", "Q08473", "FBgn0263396", "FBgn0266599", "FBgn0265297", "P21187", "FBgn0265297", "P11147", "FBgn0266599", "Q08473", "FBgn0263396", "Q8IQW5", "FBgn0031037", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10451162": { "compartment": "compartment_70101", "id": "reaction_10451162", "reactome": "R-DME-450592", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450386", "species_10451020" ], "products": [ "species_10451022" ], "modifiers": [], "additional_components": [ "FBgn0014870", "A1ZAK8", "FBgn0014870" ] }, "reaction_10451208": { "compartment": "compartment_70101", "id": "reaction_10451208", "reactome": "R-DME-450620", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451088", "species_10451202" ], "products": [ "species_10451206" ], "modifiers": [], "additional_components": [ "FBgn0014870", "A1ZAK8", "FBgn0014870", "P29310", "14-3-3zeta" ] }, "reaction_10451090": { "compartment": "compartment_70101", "id": "reaction_10451090", "reactome": "R-DME-450499", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451020" ], "products": [ "species_10451088", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0014870", "FBgn0014870" ] }, "reaction_10492435": { "compartment": "compartment_7660", "id": "reaction_10492435", "reactome": "R-DME-8938853", "name": "CDK6 binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492431", "species_10492429" ], "products": [ "species_10492433" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0016131", "Q7K306", "FBgn0016131", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10492437": { "compartment": "compartment_7660", "id": "reaction_10492437", "reactome": "R-DME-8938867", "name": "CCND3,(CCND1,CCND2) binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457981", "species_10489792" ], "products": [ "species_10489796" ], "modifiers": [], "additional_components": [ "FBgn0010315", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10489798": { "compartment": "compartment_7660", "id": "reaction_10489798", "reactome": "R-DME-8865320", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489782", "species_10489792" ], "products": [ "species_10489794" ], "modifiers": [ [ "species_10489796", "inhibitor" ] ], "additional_components": [ "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10466198": { "compartment": "compartment_876", "id": "reaction_10466198", "reactome": "R-DME-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10466195", "catalyst" ] ], "additional_components": [ "Q03720", "FBgn0003429" ] }, "reaction_10449198": { "compartment": "compartment_876", "id": "reaction_10449198", "reactome": "R-DME-432010", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10449195", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872" ] }, "reaction_10449388": { "compartment": "compartment_70101", "id": "reaction_10449388", "reactome": "R-DME-432232", "name": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10449372" ], "products": [ "species_29370", "species_10449386" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "D3DMU9", "FBgn0033635", "D3DMU9", "FBgn0033635", "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10449412": { "compartment": "compartment_876", "id": "reaction_10449412", "reactome": "R-DME-432237", "name": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449386" ], "products": [ "species_10449231" ], "modifiers": [ [ "species_10449409", "catalyst" ] ], "additional_components": [ "D3DMU9", "FBgn0033635", "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884", "O18335", "FBgn0015790", "species_29438", "Q9VWS3", "FBgn0027335", "A1Z6Z8", "FBgn0261397" ] }, "reaction_10449251": { "compartment": "compartment_876", "id": "reaction_10449251", "reactome": "R-DME-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10449248", "catalyst" ] ], "additional_components": [ "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "D3DMU9", "FBgn0033635" ] }, "reaction_10449234": { "compartment": "compartment_876", "id": "reaction_10449234", "reactome": "R-DME-432065", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10449231", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884" ] }, "reaction_10449200": { "compartment": "compartment_876", "id": "reaction_10449200", "reactome": "R-DME-432054", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10449195", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872" ] }, "reaction_10432557": { "compartment": "compartment_70101", "id": "reaction_10432557", "reactome": "R-DME-75886", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76114" ], "products": [ "species_76194", "species_76112" ], "modifiers": [ [ "species_10432552", "catalyst" ] ], "additional_components": [ "FBgn0027579" ] }, "reaction_10432635": { "compartment": "compartment_70101", "id": "reaction_10432635", "reactome": "R-DME-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10432632", "catalyst" ] ], "additional_components": [ "Q960U8", "FBgn0004797" ] }, "reaction_10484777": { "compartment": "compartment_12045", "id": "reaction_10484777", "reactome": "R-DME-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10484774", "catalyst" ] ], "additional_components": [ "Q7JYK2", "FBgn0033214", "Q7K1C2", "FBgn0033215", "A1Z739", "FBgn0033216" ] }, "reaction_10453385": { "compartment": "compartment_70101", "id": "reaction_10453385", "reactome": "R-DME-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10453382", "catalyst" ] ], "additional_components": [ "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216", "Q7K1C2", "FBgn0033215" ] }, "reaction_10432581": { "compartment": "compartment_70101", "id": "reaction_10432581", "reactome": "R-DME-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76116" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10432578", "catalyst" ] ], "additional_components": [ "Q7JY99", "FBgn0033673" ] }, "reaction_10432625": { "compartment": "compartment_70101", "id": "reaction_10432625", "reactome": "R-DME-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76108", "species_29356" ], "products": [ "species_29372", "species_76103" ], "modifiers": [ [ "species_10432618", "catalyst" ] ], "additional_components": [ "FBgn0263593" ] }, "reaction_10487894": { "compartment": "compartment_70101", "id": "reaction_10487894", "reactome": "R-DME-8848339", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_549167" ], "products": [ "species_8876730", "species_76103" ], "modifiers": [ [ "species_10487891", "catalyst" ] ], "additional_components": [ "Q9VXY8", "FBgn0030607", "E1JI03", "FBgn0036449" ] }, "reaction_10471590": { "compartment": "compartment_70101", "id": "reaction_10471590", "reactome": "R-DME-5334794", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876730", "species_10471582" ], "products": [ "species_10471588" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_8954142" ] }, "reaction_10439494": { "compartment": "compartment_5460", "id": "reaction_10439494", "reactome": "R-DME-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_31649", "species_188451" ], "modifiers": [ [ "species_10439491", "catalyst" ] ], "additional_components": [ "FBgn0022160" ] }, "reaction_209331": { "compartment": "compartment_70101", "id": "reaction_209331", "reactome": "R-DME-209331", "name": "Formation of the 'scaffold complex'", "reversible": "false", "notes": "The kinesin-related protein, Costal2 (COS), forms a microtubule-associated 'scaffold complex' with Cubitus Interruptus (CI) and the Ser/Thr protein kinase Fused (FU). CI also associates directly with the Supressor of Fused (SU(FU)) protein in a separate complex. Complexes containing CI, COS, FU and SU(FU) are detectable but rare. The Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase I alpha (CKIalpha), and Casein kinase I epsilon (DCO) all bind to the scaffold protein COS.", "reactants": [ "species_206046", "species_205832", "species_205931", "species_205716", "species_205872", "species_205729", "species_206210" ], "products": [ "species_206721" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_216136": { "compartment": "compartment_70101", "id": "reaction_216136", "reactome": "R-DME-216136", "name": "Formation of the CI:SU(FU) complex", "reversible": "false", "notes": "Cubitus Interruptus (CI) forms a separate complex with the Supressor of Fused (SU(FU)) protein.", "reactants": [ "species_206046", "species_206064" ], "products": [ "species_206802" ], "modifiers": [], "additional_components": [ "Q27279", "Phospho SU(FU)", "P19538", "ci" ] }, "reaction_209252": { "compartment": "compartment_7660", "id": "reaction_209252", "reactome": "R-DME-209252", "name": "CI75 inhibits transcription", "reversible": "false", "notes": "Upon arrival in the nucleus, truncated Cubitus Interruptus (CI75) represses transcription. Sensitive target genes include hh and dpp, but not ptc and repression depends on direct DNA-binding sites for CI75.", "reactants": [ "species_205741" ], "products": [ "species_205741" ], "modifiers": [], "additional_components": [] }, "reaction_209370": { "compartment": "compartment_13231", "id": "reaction_209370", "reactome": "R-DME-209370", "name": "CI75 transports from the cytosol to the nucleus", "reversible": "false", "notes": "Truncated Cubitus Interruptus (CI75) translocates from the cytosol to the nucleus.", "reactants": [ "species_206171" ], "products": [ "species_205741" ], "modifiers": [], "additional_components": [] }, "reaction_209313": { "compartment": "compartment_70101", "id": "reaction_209313", "reactome": "R-DME-209313", "name": "Autocleavage of HH", "reversible": "false", "notes": "The autoprocessing event results in cleavage of Hedgehog (HH) between Gly207 and Cys208, coupled to the covalent addition of cholesterol to Gly207 via an ester linkage to form N-HH.", "reactants": [ "species_176478", "species_205973" ], "products": [ "species_206216", "species_206215" ], "modifiers": [], "additional_components": [] }, "reaction_209271": { "compartment": "compartment_876", "id": "reaction_209271", "reactome": "R-DME-209271", "name": "N-HH moves from the cytosol to the extracellular region", "reversible": "false", "notes": "With the help of the transmembrane protein Dispatched (DISP), N-HH is secreted from the cytosol to the extracellular region.", "reactants": [ "species_206055", "species_206215" ], "products": [ "species_206055", "species_205888" ], "modifiers": [], "additional_components": [] }, "reaction_209272": { "compartment": "compartment_984", "id": "reaction_209272", "reactome": "R-DME-209272", "name": "N-HH binds to the transmembrane HSPG proteins", "reversible": "false", "notes": "N-HH movement between cells is facilitated by the glypicans aka heparan sulphate proteoglycan proteins (HSPGs), Dally (DALLY) and Dally-like protein (DLP) which require heparan sulphate modification by the Exostosin (EXT) family proteins tout-velu (TTV), brother of tout-velu (BOTV) and sister of tout-velu (EXT2) for this purpose. N-HH can form multimers, associated with enhanced movement of vertebrate Sonic Hedgehog, and can associate with lipophorin-containing lipophorin particles which appear to enhance N-HH movement. The protein Shifted (SHF) also facilitates HH movement.", "reactants": [ "species_205888", "species_206547" ], "products": [ "species_207018" ], "modifiers": [], "additional_components": [ "Q24114", "dally", "Q9GPL5", "DLP", "Q24114", "dally", "Q9GPL5", "DLP", "Q02936", "hh" ] }, "reaction_209357": { "compartment": "compartment_70101", "id": "reaction_209357", "reactome": "R-DME-209357", "name": "N-HH is palmitoylated by RASP", "reversible": "false", "notes": "After removal of an N-terminal signal sequence, RASP, a protein-cysteine N-palmitoyltransferase, palmitoylates the new N-terminus (CGPGR..) via a thiol intermediate that resolves into a stable amide linkage. Palmitoylation efficiency is increased by prior addition of cholesterol at the C-terminus.", "reactants": [ "species_76168", "species_206215" ], "products": [ "species_206215" ], "modifiers": [ [ "species_205927", "catalyst" ] ], "additional_components": [] }, "reaction_209185": { "compartment": "compartment_876", "id": "reaction_209185", "reactome": "R-DME-209185", "name": "Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for monomeric peptidoglycans (PGN). However, when monomeric PGN binds to PGRP-LCx receptor primarily through its elongated stem peptide, the unique disaccharide GlcNAc-MurNAc(anhydro) residues of the ligand are then presented by PGRP-LCx receptor in such a way as to make favourable interactions with the PGRP-LCa receptor ectodomain. The receptors are now in close proximity and can heterodimerise.", "reactants": [ "species_205720", "species_206681" ], "products": [ "species_206990" ], "modifiers": [], "additional_components": [ "Q9GNK5-2", "PGRP-LCx", "species_214401", "species_214401", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_209158": { "compartment": "compartment_876", "id": "reaction_209158", "reactome": "R-DME-209158", "name": "Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane", "reversible": "false", "notes": "The binding of polymeric peptidoglycan (PGN) to PGRP-LCx receptor results in adjacent PGRP-LCx receptors additionally binding to PGN. This brings the receptors into close enough proximity for them to multimerise.", "reactants": [ "species_207039", "species_205794" ], "products": [ "species_354316" ], "modifiers": [], "additional_components": [ "Q9GNK5-2", "PGRP-LCx", "species_214401", "CHEBI:28881", "species_1678743", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx" ] }, "reaction_214395": { "compartment": "compartment_70101", "id": "reaction_214395", "reactome": "R-DME-214395", "name": "Monomeric PGN bound PGRP-LE oligomerises in the cytosol", "reversible": "false", "notes": "The binding of monomeric peptidoglycans (PGN) to PGRP-LE receptor results in adjacent PGRP-LE receptors binding to the complex and forming a PGRP-LE oligomer.", "reactants": [ "species_214396" ], "products": [ "species_354246" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "species_214401", "Q9VXN9", "PGRP-LE" ] }, "reaction_10430841": { "compartment": "compartment_70101", "id": "reaction_10430841", "reactome": "R-DME-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430368", "species_10430435", "species_10430440" ], "products": [ "species_10430839" ], "modifiers": [], "additional_components": [ "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "FBgn0026250", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136" ] }, "reaction_10430837": { "compartment": "compartment_70101", "id": "reaction_10430837", "reactome": "R-DME-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430818", "species_10430440" ], "products": [ "species_10430816", "species_10430368", "species_10430440" ], "modifiers": [], "additional_components": [ "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "FBgn0026250", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "FBgn0026250" ] }, "reaction_10430527": { "compartment": "compartment_70101", "id": "reaction_10430527", "reactome": "R-DME-72622", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430525" ], "products": [ "species_10430485", "species_10430523" ], "modifiers": [], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709" ] }, "reaction_10430529": { "compartment": "compartment_70101", "id": "reaction_10430529", "reactome": "R-DME-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430497", "species_10430485", "species_10430474" ], "products": [ "species_10430499" ], "modifiers": [], "additional_components": [ "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q02748", "FBgn0001942", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10430568": { "compartment": "compartment_70101", "id": "reaction_10430568", "reactome": "R-DME-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430564", "species_10430517" ], "products": [ "species_10430566" ], "modifiers": [], "additional_components": [ "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29420", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "species_29420" ] }, "reaction_10430848": { "compartment": "compartment_70101", "id": "reaction_10430848", "reactome": "R-DME-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10430566" ], "products": [ "species_29420", "species_10430564", "species_10430459" ], "modifiers": [ [ "species_10430564", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "species_29420", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029" ] }, "reaction_10430835": { "compartment": "compartment_70101", "id": "reaction_10430835", "reactome": "R-DME-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430816", "species_10430515", "species_10430825" ], "products": [ "species_10430827" ], "modifiers": [], "additional_components": [ "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9VZP5", "FBgn0026259", "species_29438", "Q9VZP5", "FBgn0026259", "species_29438", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897" ] }, "reaction_10430833": { "compartment": "compartment_70101", "id": "reaction_10430833", "reactome": "R-DME-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430827" ], "products": [ "species_29372", "species_10430829", "species_10430831" ], "modifiers": [], "additional_components": [ "Q9VZP5", "FBgn0026259", "species_29438", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VZP5", "FBgn0026259", "species_29420", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897" ] }, "reaction_10435566": { "compartment": "compartment_70101", "id": "reaction_10435566", "reactome": "R-DME-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430816" ], "products": [ "species_10430608", "species_10435564" ], "modifiers": [], "additional_components": [ "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "FBgn0037351", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897" ] }, "reaction_10435562": { "compartment": "compartment_70101", "id": "reaction_10435562", "reactome": "R-DME-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435553", "species_10435558" ], "products": [ "species_10435560" ], "modifiers": [], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P21187", "FBgn0265297", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0037351", "Q9VNE9", "FBgn0037351", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P21187", "FBgn0265297", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10447275": { "compartment": "compartment_7660", "id": "reaction_10447275", "reactome": "R-DME-400204", "name": "PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_422139", "species_10445291", "species_10440428" ], "products": [ "species_10447235" ], "modifiers": [], "additional_components": [ "FBgn0000568", "FBgn0003964", "P20153", "FBgn0003964", "P13055", "FBgn0000568" ] }, "reaction_10447273": { "compartment": "compartment_7660", "id": "reaction_10447273", "reactome": "R-DME-400183", "name": "PPARA:RXRA heterodimer recruits corepressors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447233", "species_10447235", "species_10447226", "species_10447231" ], "products": [ "species_10447237" ], "modifiers": [], "additional_components": [ "FBgn0263933", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "FBgn0025825", "FBgn0263933", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "P20153", "FBgn0003964", "P13055", "FBgn0000568" ] }, "reaction_10447271": { "compartment": "compartment_7660", "id": "reaction_10447271", "reactome": "R-DME-400143", "name": "Fatty acid ligands activate PPARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447237", "species_10447259", "species_10447263" ], "products": [ "species_10447269", "species_10447226", "species_10447261" ], "modifiers": [], "additional_components": [ "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "Q9VH48", "FBgn0037770", "M9MS40", "FBgn0261617", "Q9VEA4", "FBgn0266195", "M9ND53", "FBgn0041092", "Q9VP05", "FBgn0037109", "Q9VYG2", "FBgn0025463", "species_9661418", "Q8INK3", "FBgn0037913", "species_3632881", "CHEBI:28364", "CHEBI:27432", "CHEBI:17351", "species_422506", "Q95RJ9", "FBgn0263933", "Q9VH48", "FBgn0037770", "M9MS40", "FBgn0261617", "Q9VEA4", "FBgn0266195", "M9ND53", "FBgn0041092", "Q9VP05", "FBgn0037109", "Q9VYG2", "FBgn0025463", "species_9661418", "P20153", "FBgn0003964", "species_3632881", "CHEBI:28364", "CHEBI:27432", "CHEBI:17351", "species_422506", "P13055", "FBgn0000568", "FBgn0025825", "FBgn0037913" ] }, "reaction_10443214": { "compartment": "compartment_17960", "id": "reaction_10443214", "reactome": "R-DME-211904", "name": "CYP4F12 18-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_352318" ], "modifiers": [ [ "species_10443211", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS79", "FBgn0015033", "O46051", "FBgn0023541", "Q9VS78", "FBgn0035790", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q27589", "FBgn0011576", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "P33269", "FBgn0005670", "Q9VVN6", "FBgn0036778" ] }, "reaction_10443224": { "compartment": "compartment_17960", "id": "reaction_10443224", "reactome": "R-DME-211924", "name": "CYP4B1 12-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215075" ], "modifiers": [ [ "species_10443221", "catalyst" ] ], "additional_components": [ "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053" ] }, "reaction_10443253": { "compartment": "compartment_17960", "id": "reaction_10443253", "reactome": "R-DME-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10443250", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34157", "species_2142739", "CHEBI:34490", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10433058": { "compartment": "compartment_17960", "id": "reaction_10433058", "reactome": "R-DME-76466", "name": "CYP4A11 12-hydroxylates DDCX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_33549", "species_113601" ], "products": [ "species_113519", "species_113564", "species_42373" ], "modifiers": [ [ "species_10433055", "catalyst" ] ], "additional_components": [ "Q9VXY0", "FBgn0030615", "Q9V557", "FBgn0033395", "Q9VLZ7", "FBgn0031925", "O46051", "FBgn0023541", "Q9VVN6", "FBgn0036778", "Q9V4T5", "FBgn0015034", "Q9VL92", "FBgn0015035", "Q9VS79", "FBgn0015033", "Q9V4T3", "FBgn0033292", "Q9VGH1", "FBgn0003312", "Q9VS78", "FBgn0035790", "Q27606", "FBgn0014469", "Q9V7G5", "FBgn0034053", "Q9VMS9", "FBgn0031693", "Q27589", "FBgn0011576", "Q9W011", "FBgn0035344", "Q9V559", "FBgn0033397", "Q9VMS8", "FBgn0031694", "P33269", "FBgn0005670", "Q9VYQ7", "FBgn0030367", "Q9V558", "FBgn0015037", "Q9VMS7", "FBgn0031695", "O46054", "FBgn0015036" ] }, "reaction_10465651": { "compartment": "compartment_5460", "id": "reaction_10465651", "reactome": "R-DME-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113600", "species_10465647" ], "products": [ "species_113563", "species_10465645" ], "modifiers": [], "additional_components": [ "Q9V3T9", "FBgn0015582", "species_113596", "species_31649", "Q9V3T9", "FBgn0015582" ] }, "reaction_10465649": { "compartment": "compartment_5460", "id": "reaction_10465649", "reactome": "R-DME-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459056", "species_10465645" ], "products": [ "species_113529", "species_10459048", "species_10465647" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "P37193", "FBgn0011769", "Q8SZA8", "FBgn0035529", "species_31649", "Q9V3T9", "FBgn0015582", "Q8SZA8", "FBgn0035529", "CHEBI:33738", "P37193", "FBgn0011769", "Q9V3T9", "FBgn0015582", "species_113596" ] }, "reaction_10459064": { "compartment": "compartment_5460", "id": "reaction_10459064", "reactome": "R-DME-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10459062" ], "products": [ "species_10459032" ], "modifiers": [], "additional_components": [ "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "Q9W385", "FBgn0030092", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "species_111793", "Q9W385", "FBgn0030092" ] }, "reaction_10491819": { "compartment": "compartment_5460", "id": "reaction_10491819", "reactome": "R-DME-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491798", "species_10491810" ], "products": [ "species_10491796", "species_10491812" ], "modifiers": [ [ "species_10491817", "catalyst" ] ], "additional_components": [ "Q8SXQ5", "FBgn0030584", "CHEBI:33739", "Q9VC65", "FBgn0039205", "Q8T3X9", "FBgn0026666", "FBgn0030584", "Q9VC65", "FBgn0039205", "Q8T3X9", "FBgn0026666", "CHEBI:49883", "FBgn0263606" ] }, "reaction_10459059": { "compartment": "compartment_5460", "id": "reaction_10459059", "reactome": "R-DME-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10459048", "species_10459032" ], "products": [ "species_10459056", "species_10459050", "species_379697" ], "modifiers": [ [ "species_10459032", "catalyst" ], [ "species_10459048", "catalyst" ] ], "additional_components": [ "Q8SZA8", "FBgn0035529", "CHEBI:33738", "P37193", "FBgn0011769", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "species_111793", "Q9W385", "FBgn0030092", "CHEBI:33737", "P37193", "FBgn0011769", "Q8SZA8", "FBgn0035529", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "CHEBI:33739", "Q9W385", "FBgn0030092", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "species_111793", "Q9W385", "FBgn0030092", "Q8SZA8", "FBgn0035529", "CHEBI:33738", "P37193", "FBgn0011769" ] }, "reaction_10443243": { "compartment": "compartment_12045", "id": "reaction_10443243", "reactome": "R-DME-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211993", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211952" ], "modifiers": [ [ "species_10432787", "catalyst" ] ], "additional_components": [ "Q95078", "FBgn0010383", "Q9VWR5", "FBgn0004959" ] }, "reaction_10432790": { "compartment": "compartment_12045", "id": "reaction_10432790", "reactome": "R-DME-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39703", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76455" ], "modifiers": [ [ "species_10432787", "catalyst" ] ], "additional_components": [ "Q95078", "FBgn0010383", "Q9VWR5", "FBgn0004959" ] }, "reaction_10465550": { "compartment": "compartment_876", "id": "reaction_10465550", "reactome": "R-DME-2327746", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442018", "species_10442026" ], "products": [ "species_10465548" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "species_266099", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10442028": { "compartment": "compartment_876", "id": "reaction_10442028", "reactome": "R-DME-202723", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442020", "species_10442024", "species_266099" ], "products": [ "species_10442026" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "species_266099", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163" ] }, "reaction_10466200": { "compartment": "compartment_984", "id": "reaction_10466200", "reactome": "R-DME-2545196", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442018" ], "products": [ "species_10442020" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163" ] }, "reaction_10498752": { "compartment": "compartment_7660", "id": "reaction_10498752", "reactome": "R-DME-9708430", "name": "XPO1 (CRM1) binds to BACH1:Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498740", "species_10437629" ], "products": [ "species_10498742" ], "modifiers": [], "additional_components": [ "Q9VYJ8", "FBgn0030417", "FBgn0020497", "Q9TVM2", "FBgn0020497", "Q9VYJ8", "FBgn0030417" ] }, "reaction_10455099": { "compartment": "compartment_876", "id": "reaction_10455099", "reactome": "R-DME-917870", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310" ], "products": [ "species_9707308" ], "modifiers": [ [ "species_10441404", "catalyst" ] ], "additional_components": [ "species_71185", "B7YZU3", "FBgn0033387", "Q8INF8", "FBgn0051321", "Q9VY22", "FBgn0030576", "A1Z7R6", "FBgn0033388", "Q1EC10", "FBgn0050345", "Q9VA14", "FBgn0039817", "Q0E8E1", "FBgn0260388", "Q961H2", "FBgn0050344" ] }, "reaction_10498750": { "compartment": "compartment_70101", "id": "reaction_10498750", "reactome": "R-DME-9708423", "name": "XPO1:BACH1:Hemes are transported out of the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498742" ], "products": [ "species_10498748" ], "modifiers": [], "additional_components": [ "Q9TVM2", "FBgn0020497", "Q9VYJ8", "FBgn0030417", "Q9VYJ8", "FBgn0030417", "Q9TVM2", "FBgn0020497" ] }, "reaction_10458287": { "compartment": "compartment_70101", "id": "reaction_10458287", "reactome": "R-DME-1247665", "name": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425425", "species_352022" ], "products": [ "species_188972", "species_111627" ], "modifiers": [ [ "species_10458178", "catalyst" ] ], "additional_components": [ "Q9VT48", "FBgn0036043" ] }, "reaction_10458285": { "compartment": "compartment_70101", "id": "reaction_10458285", "reactome": "R-DME-1247649", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10449195", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872" ] }, "reaction_10458236": { "compartment": "compartment_984", "id": "reaction_10458236", "reactome": "R-DME-1237059", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10458231", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VH26", "FBgn0037788" ] }, "reaction_10458283": { "compartment": "compartment_70101", "id": "reaction_10458283", "reactome": "R-DME-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10450042", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10459562": { "compartment": "compartment_70101", "id": "reaction_10459562", "reactome": "R-DME-1475436", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10459557", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10458234": { "compartment": "compartment_984", "id": "reaction_10458234", "reactome": "R-DME-1237047", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10458231", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VH26", "FBgn0037788" ] }, "reaction_10459560": { "compartment": "compartment_70101", "id": "reaction_10459560", "reactome": "R-DME-1475435", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10459557", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10457039": { "compartment": "compartment_70101", "id": "reaction_10457039", "reactome": "R-DME-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456947", "species_113592", "species_10456941" ], "products": [ "species_111294", "species_10456939", "species_10457005", "species_76577" ], "modifiers": [ [ "species_10456947", "catalyst" ] ], "additional_components": [ "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10457007": { "compartment": "compartment_70101", "id": "reaction_10457007", "reactome": "R-DME-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457005" ], "products": [ "species_983123", "species_10456828" ], "modifiers": [], "additional_components": [ "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653" ] }, "reaction_10457036": { "compartment": "compartment_70101", "id": "reaction_10457036", "reactome": "R-DME-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457028", "species_113592", "species_29926", "species_10426987" ], "products": [ "species_111294", "species_10457030", "species_29926", "species_76577" ], "modifiers": [ [ "species_10457028", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10457033": { "compartment": "compartment_70101", "id": "reaction_10457033", "reactome": "R-DME-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457030", "species_10456939" ], "products": [ "species_10457028", "species_10456941" ], "modifiers": [ [ "species_10456939", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436" ] }, "reaction_10456950": { "compartment": "compartment_70101", "id": "reaction_10456950", "reactome": "R-DME-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10456943" ], "products": [ "species_111294", "species_10456947", "species_10456939", "species_76577" ], "modifiers": [ [ "species_10456828", "catalyst" ] ], "additional_components": [ "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653" ] }, "reaction_10457186": { "compartment": "compartment_70101", "id": "reaction_10457186", "reactome": "R-DME-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10457183", "catalyst" ] ], "additional_components": [ "Q9V6K1", "FBgn0020370", "X2JEJ0", "FBgn0030038", "Q8IRH1", "FBgn0261243", "Q0KI25", "FBgn0039064", "Q0KI00", "FBgn0263236", "Q9W2S8", "FBgn0030222", "Q9W2S7", "FBgn0030223", "Q9W1S1", "FBgn0046253", "Q9VTL4", "FBgn0036186", "Q9VJN2", "FBgn0028935", "Q9VD87", "FBgn0038897", "Q9VAM2", "FBgn0039656", "Q95SR0", "FBgn0051445", "Q8SWX4", "FBgn0051343", "Q8MRN5", "FBgn0051343" ] }, "reaction_10457041": { "compartment": "compartment_70101", "id": "reaction_10457041", "reactome": "R-DME-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983035", "species_10456828", "species_10456941" ], "products": [ "species_10456943" ], "modifiers": [], "additional_components": [ "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653" ] }, "reaction_10457009": { "compartment": "compartment_70101", "id": "reaction_10457009", "reactome": "R-DME-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_983032", "species_10426987", "species_8942986", "species_983036" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_209377": { "compartment": "compartment_984", "id": "reaction_209377", "reactome": "R-DME-209377", "name": "Polymeric PGN binds to PGRP-LCx at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCx, receptor exhibits strong affinity for both polymeric and monomeric peptidoglycans.", "reactants": [ "species_206912", "species_205794" ], "products": [ "species_207039" ], "modifiers": [], "additional_components": [ "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "species_214401", "CHEBI:28881", "species_1678743" ] }, "reaction_209355": { "compartment": "compartment_984", "id": "reaction_209355", "reactome": "R-DME-209355", "name": "Monomeric PGN binds to PGRP-LCx at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for peptidoglycans (PGN). However, PGRP-LCx receptor exhibits strong affinity for them.", "reactants": [ "species_205686", "species_205794" ], "products": [ "species_206681" ], "modifiers": [], "additional_components": [ "Q9GNK5-2", "PGRP-LCx", "species_214401" ] }, "reaction_214410": { "compartment": "compartment_70101", "id": "reaction_214410", "reactome": "R-DME-214410", "name": "Monomeric PGN binds to PGRP-LE in the cytosol", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LE receptor contains no predicted transmembrane domain or signal sequence and so is predicted to be an intracellular receptor. The recognition of the monomeric diaminopimelic acid (DAP)-type peptidoglycan (PGN) tracheal cytotoxin, TCT by PGRP-LE occurs intracellularly. However, it is postulated that the PGRP domain of a truncated PGRP-LE can also function outside the cell in a CD14-like manner by presenting DAP-type PGNs to cell surface PGRP-LC receptors.", "reactants": [ "species_214412", "species_214401" ], "products": [ "species_214396" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE" ] }, "reaction_214418": { "compartment": "compartment_70101", "id": "reaction_214418", "reactome": "R-DME-214418", "name": "REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The NF-kappaB orthologue, Relish, binds to the caspase-8 orthologue, DREDD.", "reactants": [ "species_214404", "species_206135" ], "products": [ "species_214406" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4" ] }, "reaction_209244": { "compartment": "compartment_70101", "id": "reaction_209244", "reactome": "R-DME-209244", "name": "REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The NF-kappaB orthologue, Relish, binds to the caspase-8 orthologue, DREDD.", "reactants": [ "species_354317", "species_206135" ], "products": [ "species_354323" ], "modifiers": [], "additional_components": [ "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_209221": { "compartment": "compartment_70101", "id": "reaction_209221", "reactome": "R-DME-209221", "name": "Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Upon ligand binding and receptor multimerisation at the plasma membrane, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the cytoplasmic part of the receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.", "reactants": [ "species_354313", "species_205887", "species_205876", "species_206183" ], "products": [ "species_354317" ], "modifiers": [], "additional_components": [ "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_214405": { "compartment": "compartment_70101", "id": "reaction_214405", "reactome": "R-DME-214405", "name": "Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Upon monomeric peptidoglycan (PGN) binding and receptor multimerisation in the cytosol, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the PGRP-LE receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.", "reactants": [ "species_205887", "species_205876", "species_206183", "species_354246" ], "products": [ "species_214404" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4" ] }, "reaction_10433119": { "compartment": "compartment_7660", "id": "reaction_10433119", "reactome": "R-DME-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433113", "species_72084", "species_29428" ], "products": [ "species_10433117" ], "modifiers": [], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433149": { "compartment": "compartment_7660", "id": "reaction_10433149", "reactome": "R-DME-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429248", "species_10429169" ], "products": [ "species_10429250" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10433131": { "compartment": "compartment_7660", "id": "reaction_10433131", "reactome": "R-DME-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433121", "species_113571" ], "products": [ "species_10433128", "species_111349" ], "modifiers": [ [ "species_10433121", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "species_5696194", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433147": { "compartment": "compartment_7660", "id": "reaction_10433147", "reactome": "R-DME-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429162", "species_10429167" ], "products": [ "species_10429169" ], "modifiers": [], "additional_components": [ "FBgn0022943", "FBgn0022942", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10433115": { "compartment": "compartment_7660", "id": "reaction_10433115", "reactome": "R-DME-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433105", "species_10433089", "species_10433111" ], "products": [ "species_10433113" ], "modifiers": [], "additional_components": [ "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "FBgn0040273", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433145": { "compartment": "compartment_7660", "id": "reaction_10433145", "reactome": "R-DME-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10433138" ], "products": [ "species_10429248", "species_77502", "species_10431174", "species_10433142", "species_10433111" ], "modifiers": [ [ "species_10433138", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VY44", "FBgn0030556", "Q9VJQ4", "FBgn0286027", "FBgn0040273", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433095": { "compartment": "compartment_7660", "id": "reaction_10433095", "reactome": "R-DME-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433093", "species_10433087" ], "products": [ "species_10433089" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "FBgn0030556", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10433124": { "compartment": "compartment_7660", "id": "reaction_10433124", "reactome": "R-DME-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433117" ], "products": [ "species_113550", "species_10433121" ], "modifiers": [ [ "species_10433117", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433140": { "compartment": "compartment_7660", "id": "reaction_10433140", "reactome": "R-DME-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433133" ], "products": [ "species_10433138" ], "modifiers": [], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433091": { "compartment": "compartment_7660", "id": "reaction_10433091", "reactome": "R-DME-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433089" ], "products": [ "species_10433089" ], "modifiers": [], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10433136": { "compartment": "compartment_7660", "id": "reaction_10433136", "reactome": "R-DME-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433128" ], "products": [ "species_10433133" ], "modifiers": [ [ "species_10433128", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "species_5696194", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "species_5696194" ] }, "reaction_10479695": { "compartment": "compartment_984", "id": "reaction_10479695", "reactome": "R-DME-6785213", "name": "LIPC dimer binds heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1604784", "species_10478382" ], "products": [ "species_10478384" ], "modifiers": [], "additional_components": [ "Q9VB91", "FBgn0039473", "A1ZAL5", "FBgn0034166", "Q9VX70", "FBgn0265267", "Q9VB90", "FBgn0039474", "Q9VX69", "FBgn0030828", "Q9VB89", "FBgn0039475", "Q9VX01", "FBgn0030884", "Q9VB88", "FBgn0039476", "Q9VU78", "FBgn0036367", "Q7K3Z8", "FBgn0032029", "Q9VRW5", "FBgn0035697", "Q4V566", "FBgn0085476", "Q9VLU1", "FBgn0031976", "Q0E8T1", "FBgn0250847", "Q9VJH1", "FBgn0032612", "P06607", "FBgn0004047", "Q9VEY9", "FBgn0038398", "P02844", "FBgn0005391", "Q9VBQ2", "FBgn0039344", "P02843", "FBgn0004045", "Q9VB94", "FBgn0039470", "M9NFL7", "FBgn0036977", "Q9W448", "FBgn0029831", "Q9VB93", "FBgn0039471", "M9MRT1", "FBgn0032289", "Q9W304", "FBgn0030162", "Q9VB92", "FBgn0039472", "A8DYT7", "FBgn0085477", "Q9VZN6", "FBgn0035453", "Q9VB91", "FBgn0039473", "A1ZAL5", "FBgn0034166", "Q9VX70", "FBgn0265267", "Q9VB90", "FBgn0039474", "Q9VX69", "FBgn0030828", "Q9VB89", "FBgn0039475", "Q9VX01", "FBgn0030884", "Q9VB88", "FBgn0039476", "Q9VU78", "FBgn0036367", "Q7K3Z8", "FBgn0032029", "Q9VRW5", "FBgn0035697", "Q4V566", "FBgn0085476", "Q9VLU1", "FBgn0031976", "Q0E8T1", "FBgn0250847", "Q9VJH1", "FBgn0032612", "P06607", "FBgn0004047", "Q9VEY9", "FBgn0038398", "P02844", "FBgn0005391", "Q9VBQ2", "FBgn0039344", "P02843", "FBgn0004045", "Q9VB94", "FBgn0039470", "M9NFL7", "FBgn0036977", "Q9W448", "FBgn0029831", "Q9VB93", "FBgn0039471", "M9MRT1", "FBgn0032289", "Q9W304", "FBgn0030162", "Q9VB92", "FBgn0039472", "A8DYT7", "FBgn0085477", "Q9VZN6", "FBgn0035453", "species_1604784" ] }, "reaction_10479623": { "compartment": "compartment_984", "id": "reaction_10479623", "reactome": "R-DME-6784861", "name": "HSPG binds LPL dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479619", "species_1678620" ], "products": [ "species_10479621" ], "modifiers": [], "additional_components": [ "Q9VB90", "FBgn0039474", "Q9VB89", "FBgn0039475", "Q9VB88", "FBgn0039476", "Q7K3Z8", "FBgn0032029", "Q4V566", "FBgn0085476", "Q0E8T1", "FBgn0250847", "P06607", "FBgn0004047", "P02844", "FBgn0005391", "P02843", "FBgn0004045", "M9NFL7", "FBgn0036977", "M9MRT1", "FBgn0032289", "A8DYT7", "FBgn0085477", "A1ZAL5", "FBgn0034166", "Q9W448", "FBgn0029831", "Q9W304", "FBgn0030162", "Q9VZN6", "FBgn0035453", "Q9VX70", "FBgn0265267", "Q9VX69", "FBgn0030828", "Q9VX01", "FBgn0030884", "Q9VU78", "FBgn0036367", "Q9VRW5", "FBgn0035697", "Q9VLU1", "FBgn0031976", "Q9VJH1", "FBgn0032612", "Q9VEY9", "FBgn0038398", "Q9VBQ2", "FBgn0039344", "Q9VB94", "FBgn0039470", "Q9VB93", "FBgn0039471", "Q9VB92", "FBgn0039472", "Q9VB91", "FBgn0039473", "species_1678620", "Q9VB90", "FBgn0039474", "Q9VB89", "FBgn0039475", "Q9VB88", "FBgn0039476", "Q7K3Z8", "FBgn0032029", "Q4V566", "FBgn0085476", "Q0E8T1", "FBgn0250847", "P06607", "FBgn0004047", "P02844", "FBgn0005391", "P02843", "FBgn0004045", "M9NFL7", "FBgn0036977", "M9MRT1", "FBgn0032289", "A8DYT7", "FBgn0085477", "A1ZAL5", "FBgn0034166", "Q9W448", "FBgn0029831", "Q9W304", "FBgn0030162", "Q9VZN6", "FBgn0035453", "Q9VX70", "FBgn0265267", "Q9VX69", "FBgn0030828", "Q9VX01", "FBgn0030884", "Q9VU78", "FBgn0036367", "Q9VRW5", "FBgn0035697", "Q9VLU1", "FBgn0031976", "Q9VJH1", "FBgn0032612", "Q9VEY9", "FBgn0038398", "Q9VBQ2", "FBgn0039344", "Q9VB94", "FBgn0039470", "Q9VB93", "FBgn0039471", "Q9VB92", "FBgn0039472", "Q9VB91", "FBgn0039473" ] }, "reaction_10478387": { "compartment": "compartment_984", "id": "reaction_10478387", "reactome": "R-DME-5694109", "name": "LIPC dimer hydrolyses TAG to DAG and FA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_422024", "species_174675" ], "modifiers": [ [ "species_10478384", "catalyst" ] ], "additional_components": [ "Q9VB91", "FBgn0039473", "A1ZAL5", "FBgn0034166", "Q9VX70", "FBgn0265267", "Q9VB90", "FBgn0039474", "Q9VX69", "FBgn0030828", "Q9VB89", "FBgn0039475", "Q9VX01", "FBgn0030884", "Q9VB88", "FBgn0039476", "Q9VU78", "FBgn0036367", "Q7K3Z8", "FBgn0032029", "Q9VRW5", "FBgn0035697", "Q4V566", "FBgn0085476", "Q9VLU1", "FBgn0031976", "Q0E8T1", "FBgn0250847", "Q9VJH1", "FBgn0032612", "P06607", "FBgn0004047", "Q9VEY9", "FBgn0038398", "P02844", "FBgn0005391", "Q9VBQ2", "FBgn0039344", "P02843", "FBgn0004045", "Q9VB94", "FBgn0039470", "M9NFL7", "FBgn0036977", "Q9W448", "FBgn0029831", "Q9VB93", "FBgn0039471", "M9MRT1", "FBgn0032289", "Q9W304", "FBgn0030162", "Q9VB92", "FBgn0039472", "A8DYT7", "FBgn0085477", "Q9VZN6", "FBgn0035453", "species_1604784" ] }, "reaction_10435351": { "compartment": "compartment_984", "id": "reaction_10435351", "reactome": "R-DME-140806", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435285", "species_9693058" ], "products": [ "species_10435349" ], "modifiers": [], "additional_components": [ "Q0E8V6", "FBgn0051902", "Q9VFC1", "FBgn0038299", "Q0E8C8", "FBgn0262057", "Q9VA48", "FBgn0039795", "Q9VWB4", "FBgn0036969", "A1Z6V5", "FBgn0024293", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q9VVW1", "FBgn0015586", "A1Z6R4", "FBgn0033113", "Q8SYY7", "FBgn0044011", "Q9VPH9", "FBgn0036970", "A1Z6R3", "FBgn0033112", "Q7YTY6", "FBgn0028988", "Q9VLZ8", "FBgn0083141", "A1Z6I3", "FBgn0263109", "Q7KA66", "FBgn0024294", "Q9VLV3", "FBgn0053121", "Q7K8Y5", "FBgn0265137", "Q9VLU4", "FBgn0031973", "Q7K508", "FBgn0033574", "Q9VLQ7", "FBgn0028987", "Q7JWX3", "FBgn0002930", "Q9VL44", "FBgn0032178", "Q7JV69", "FBgn0028983", "Q9VII7", "FBgn0028986", "Q4V3G2", "FBgn0034195", "Q9VH46", "FBgn0037772", "Q3HKQ3", "FBgn0052203", "Q9VFC2", "FBgn0028984", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902" ] }, "reaction_10472771": { "compartment": "compartment_984", "id": "reaction_10472771", "reactome": "R-DME-5591086", "name": "SERPINA5 binds activated protein C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472753", "species_10472767" ], "products": [ "species_10472769" ], "modifiers": [ [ "species_977180", "catalyst" ] ], "additional_components": [ "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178" ] }, "reaction_10496558": { "compartment": "compartment_984", "id": "reaction_10496558", "reactome": "R-DME-9015111", "name": "Factor Xa inhibitors binds Xa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9038743", "species_10496554" ], "products": [ "species_10496556" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016" ] }, "reaction_10465672": { "compartment": "compartment_984", "id": "reaction_10465672", "reactome": "R-DME-2396079", "name": "VTN binds Plasminogen activator inhibitor- 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443474", "species_10452309" ], "products": [ "species_10465670" ], "modifiers": [], "additional_components": [ "FBgn0024366", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "O46099", "FBgn0024366" ] }, "reaction_10466600": { "compartment": "compartment_984", "id": "reaction_10466600", "reactome": "R-DME-2681681", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451", "species_10465757" ], "products": [ "species_10466598" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163" ] }, "reaction_10465811": { "compartment": "compartment_876", "id": "reaction_10465811", "reactome": "R-DME-2426471", "name": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443474", "species_10443447" ], "products": [ "species_10465809" ], "modifiers": [], "additional_components": [ "FBgn0024366", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "O46099", "FBgn0024366" ] }, "reaction_10465968": { "compartment": "compartment_984", "id": "reaction_10465968", "reactome": "R-DME-2467665", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465960", "species_10465964" ], "products": [ "species_10465966" ], "modifiers": [], "additional_components": [ "FBgn0015773", "P14599", "FBgn0000108", "P14599", "FBgn0000108", "Q24567", "FBgn0015773" ] }, "reaction_10462495": { "compartment": "compartment_12045", "id": "reaction_10462495", "reactome": "R-DME-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10462488", "species_1650779" ], "products": [ "species_1650769", "species_159751", "species_10462492" ], "modifiers": [ [ "species_10462486", "catalyst" ] ], "additional_components": [ "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793" ] }, "reaction_10462527": { "compartment": "compartment_12045", "id": "reaction_10462527", "reactome": "R-DME-1981157", "name": "Glucosylation of collagen propeptide hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462517", "species_173594" ], "products": [ "species_158602", "species_10462524" ], "modifiers": [ [ "species_10462484", "catalyst" ] ], "additional_components": [ "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147" ] }, "reaction_10462555": { "compartment": "compartment_17957", "id": "reaction_10462555", "reactome": "R-DME-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462529" ], "products": [ "species_10462553" ], "modifiers": [], "additional_components": [ "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10493353": { "compartment": "compartment_17957", "id": "reaction_10493353", "reactome": "R-DME-8944257", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462830" ], "products": [ "species_10462854" ], "modifiers": [], "additional_components": [ "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10462622": { "compartment": "compartment_984", "id": "reaction_10462622", "reactome": "R-DME-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462581" ], "products": [ "species_10462607" ], "modifiers": [ [ "species_10462619", "catalyst" ] ], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468", "Q9VC47", "FBgn0004885", "P25723", "FBgn0003719" ] }, "reaction_10462520": { "compartment": "compartment_12045", "id": "reaction_10462520", "reactome": "R-DME-1981128", "name": "Galactosylation of collagen propeptide hydroxylysines by PLOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10462515" ], "products": [ "species_10462517", "species_158602" ], "modifiers": [ [ "species_10462484", "catalyst" ] ], "additional_components": [ "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147" ] }, "reaction_10462629": { "compartment": "compartment_984", "id": "reaction_10462629", "reactome": "R-DME-2002440", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462607" ], "products": [ "species_10459392" ], "modifiers": [ [ "species_10462626", "catalyst" ] ], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468", "Q9VC47", "FBgn0004885", "P25723", "FBgn0003719" ] }, "reaction_10462513": { "compartment": "compartment_17957", "id": "reaction_10462513", "reactome": "R-DME-1981120", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10462506" ], "products": [ "species_158602", "species_10462510" ], "modifiers": [ [ "species_10462506", "catalyst" ] ], "additional_components": [ "Q8IPK4", "FBgn0051915", "Q8IPK4", "FBgn0051915", "Q8IPK4", "FBgn0051915" ] }, "reaction_10443439": { "compartment": "compartment_984", "id": "reaction_10443439", "reactome": "R-DME-216048", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443380", "species_10443435" ], "products": [ "species_10443437" ], "modifiers": [], "additional_components": [ "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q9W4Y3", "FBgn0284408", "Q8IP51", "FBgn0261563", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q9W4Y3", "FBgn0284408", "Q8IP51", "FBgn0261563", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657" ] }, "reaction_10469164": { "compartment": "compartment_876", "id": "reaction_10469164", "reactome": "R-DME-3907292", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469158", "species_10469160" ], "products": [ "species_10469162" ], "modifiers": [], "additional_components": [ "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "Q9W4Y3", "FBgn0284408", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "Q9W4Y3", "FBgn0284408", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "P11584", "FBgn0004657" ] }, "reaction_10443932": { "compartment": "compartment_984", "id": "reaction_10443932", "reactome": "R-DME-349626", "name": "Integrin alpha2beta1 binds laminin-332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443411", "species_10443928" ], "products": [ "species_10443930" ], "modifiers": [], "additional_components": [ "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10443465": { "compartment": "compartment_984", "id": "reaction_10443465", "reactome": "R-DME-216058", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443459", "species_10443461" ], "products": [ "species_10443463" ], "modifiers": [], "additional_components": [ "P11584", "FBgn0004657", "Q24247", "FBgn0004456", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "P11584", "FBgn0004657", "Q24247", "FBgn0004456" ] }, "reaction_10466975": { "compartment": "compartment_876", "id": "reaction_10466975", "reactome": "R-DME-2731074", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463847", "species_10466971" ], "products": [ "species_10466973" ], "modifiers": [], "additional_components": [ "FBgn0010415", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P49415", "FBgn0010415" ] }, "reaction_10466987": { "compartment": "compartment_876", "id": "reaction_10466987", "reactome": "R-DME-2731141", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463847", "species_10443451" ], "products": [ "species_10466985" ], "modifiers": [], "additional_components": [ "FBgn0010415", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P49415", "FBgn0010415" ] }, "reaction_10466983": { "compartment": "compartment_876", "id": "reaction_10466983", "reactome": "R-DME-2731122", "name": "Syndecans 1, 2 & 4 bind VTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443474", "species_10463847" ], "products": [ "species_10466981" ], "modifiers": [], "additional_components": [ "FBgn0024366", "FBgn0010415", "P49415", "FBgn0010415", "O46099", "FBgn0024366" ] }, "reaction_10467077": { "compartment": "compartment_876", "id": "reaction_10467077", "reactome": "R-DME-2750187", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467073", "species_10447182" ], "products": [ "species_10467075" ], "modifiers": [], "additional_components": [ "P49415", "FBgn0010415", "species_179856", "species_114519", "P05130", "FBgn0003091", "species_114519", "P05130", "FBgn0003091", "P49415", "FBgn0010415", "species_179856" ] }, "reaction_10466979": { "compartment": "compartment_876", "id": "reaction_10466979", "reactome": "R-DME-2731078", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437858", "species_10463849" ], "products": [ "species_10466977" ], "modifiers": [], "additional_components": [ "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "FBgn0010415", "P49415", "FBgn0010415", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10443455": { "compartment": "compartment_984", "id": "reaction_10443455", "reactome": "R-DME-216050", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443449", "species_10443451" ], "products": [ "species_10443453" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "P11584", "FBgn0004657", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10498486": { "compartment": "compartment_876", "id": "reaction_10498486", "reactome": "R-DME-9679740", "name": "ITGA4:ITGB1 binds natalizumab", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9679737", "species_10441036" ], "products": [ "species_10498484" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10469592": { "compartment": "compartment_984", "id": "reaction_10469592", "reactome": "R-DME-4085133", "name": "LUM (lumican) binds integrin alpha2beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469588", "species_10443928" ], "products": [ "species_10469590" ], "modifiers": [], "additional_components": [ "FBgn0028872", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "M9MSI4", "FBgn0028872" ] }, "reaction_10443635": { "compartment": "compartment_876", "id": "reaction_10443635", "reactome": "R-DME-265422", "name": "Interaction of integrin alphaEbeta7 with Cadherin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442033", "species_10443631" ], "products": [ "species_10443633" ], "modifiers": [], "additional_components": [ "FBgn0262018", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "Q9VJB6", "FBgn0262018" ] }, "reaction_10465779": { "compartment": "compartment_984", "id": "reaction_10465779", "reactome": "R-DME-2426259", "name": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465761", "species_10442024" ], "products": [ "species_10465777" ], "modifiers": [], "additional_components": [ "Q9VM97", "FBgn0031850", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q9VM97", "FBgn0031850" ] }, "reaction_10443648": { "compartment": "compartment_984", "id": "reaction_10443648", "reactome": "R-DME-265429", "name": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443642", "species_10443644" ], "products": [ "species_10443646" ], "modifiers": [], "additional_components": [ "Q9VM97", "FBgn0031850", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "O44386", "FBgn0286785", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "O44386", "FBgn0286785", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "Q9VM97", "FBgn0031850" ] }, "reaction_10465638": { "compartment": "compartment_984", "id": "reaction_10465638", "reactome": "R-DME-2395364", "name": "LTBP4 binds TGF-Beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465600", "species_10465570" ], "products": [ "species_10465636" ], "modifiers": [], "additional_components": [ "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P98163", "FBgn0004649", "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649", "Q9V4B8", "FBgn0051999", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234" ] }, "reaction_10465606": { "compartment": "compartment_876", "id": "reaction_10465606", "reactome": "R-DME-2395320", "name": "Latent TGF-beta-1 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465600", "species_10465602" ], "products": [ "species_10465604" ], "modifiers": [], "additional_components": [ "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234" ] }, "reaction_10465668": { "compartment": "compartment_876", "id": "reaction_10465668", "reactome": "R-DME-2396029", "name": "Latent TGF-beta-3 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443447", "species_10465628" ], "products": [ "species_10465666" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10465634": { "compartment": "compartment_984", "id": "reaction_10465634", "reactome": "R-DME-2395328", "name": "LTBP1, LTBP3 bind TGF-Beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465608", "species_10465630" ], "products": [ "species_10465632" ], "modifiers": [], "additional_components": [ "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649" ] }, "reaction_10489074": { "compartment": "compartment_876", "id": "reaction_10489074", "reactome": "R-DME-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489064" ], "products": [ "species_10489072" ], "modifiers": [], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "A8JRD0", "FBgn0066101", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "A8JRD0", "FBgn0066101" ] }, "reaction_10493840": { "compartment": "compartment_7660", "id": "reaction_10493840", "reactome": "R-DME-8952128", "name": "RUNX3 binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10467611" ], "products": [ "species_10493838" ], "modifiers": [], "additional_components": [ "FBgn0083981", "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "M9PI08", "FBgn0083981" ] }, "reaction_10491733": { "compartment": "compartment_7660", "id": "reaction_10491733", "reactome": "R-DME-8878117", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10491729" ], "products": [ "species_10491731" ], "modifiers": [ [ "species_10437860", "catalyst" ] ], "additional_components": [ "FBgn0083981", "FBgn0004607", "P28167", "FBgn0004607", "M9PI08", "FBgn0083981", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10491740": { "compartment": "compartment_7660", "id": "reaction_10491740", "reactome": "R-DME-8878143", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10491736" ], "products": [ "species_10491738" ], "modifiers": [], "additional_components": [ "FBgn0083981", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "M9PI08", "FBgn0083981" ] }, "reaction_10436609": { "compartment": "compartment_7660", "id": "reaction_10436609", "reactome": "R-DME-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10436603" ], "products": [ "species_10436607" ], "modifiers": [], "additional_components": [ "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357", "species_76577", "A1Z7Q8", "FBgn0260972" ] }, "reaction_10489849": { "compartment": "compartment_7660", "id": "reaction_10489849", "reactome": "R-DME-8865613", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489819", "species_10489827" ], "products": [ "species_10489847" ], "modifiers": [], "additional_components": [ "FBgn0011785", "FBgn0001199", "P02299", "FBgn0001199", "Q9VC96", "FBgn0011785" ] }, "reaction_10489823": { "compartment": "compartment_7660", "id": "reaction_10489823", "reactome": "R-DME-8865605", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489819", "species_10467677" ], "products": [ "species_10489821" ], "modifiers": [], "additional_components": [ "FBgn0011785", "FBgn0000212", "P25439", "FBgn0000212", "Q9VC96", "FBgn0011785" ] }, "reaction_10454519": { "compartment": "compartment_13231", "id": "reaction_10454519", "reactome": "R-DME-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454427" ], "products": [ "species_10454513" ], "modifiers": [ [ "species_10454517", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E", "O18388", "FBgn0262743", "Q24151", "Stat92E", "O76521", "FBgn0024889" ] }, "reaction_10454155": { "compartment": "compartment_13231", "id": "reaction_10454155", "reactome": "R-DME-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454149" ], "products": [ "species_10454153" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10496089": { "compartment": "compartment_70101", "id": "reaction_10496089", "reactome": "R-DME-9009950", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8983696" ], "products": [ "species_70106", "species_113592", "species_76577" ], "modifiers": [ [ "species_10496086", "catalyst" ] ], "additional_components": [ "species_113592", "FBgn0051759" ] }, "reaction_10461341": { "compartment": "compartment_70101", "id": "reaction_10461341", "reactome": "R-DME-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461329", "species_10461337" ], "products": [ "species_10461335", "species_10461339" ], "modifiers": [], "additional_components": [ "Q94981", "FBgn0017418", "E8NHA2", "FBgn0035207", "Q9VZ73", "FBgn0035584", "Q7K738", "FBgn0026316", "P52487", "FBgn0017456", "E1JIV5", "FBgn0053100", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A8DZ29", "FBgn0023213", "Q9VCH1", "FBgn0260634", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A8DZ29", "FBgn0023213", "Q9VCH1", "FBgn0260634", "Q94981", "FBgn0017418", "E8NHA2", "FBgn0035207", "Q9VZ73", "FBgn0035584", "Q7K738", "FBgn0026316", "P52487", "FBgn0017456", "E1JIV5", "FBgn0053100" ] }, "reaction_10453068": { "compartment": "compartment_5460", "id": "reaction_10453068", "reactome": "R-DME-507775", "name": "PXLP-K341-GPT2 transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_379697" ], "products": [ "species_113557", "species_113552" ], "modifiers": [ [ "species_10453063", "catalyst" ] ], "additional_components": [ "Q9VYD9", "FBgn0030478" ] }, "reaction_10428164": { "compartment": "compartment_70101", "id": "reaction_10428164", "reactome": "R-DME-70524", "name": "PXLP-K314-GPT transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_29398" ], "products": [ "species_29406", "species_29432" ], "modifiers": [ [ "species_10428159", "catalyst" ] ], "additional_components": [ "Q9VYD9", "FBgn0030478" ] }, "reaction_10443038": { "compartment": "compartment_70101", "id": "reaction_10443038", "reactome": "R-DME-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10443035" ], "products": [ "species_10442948" ], "modifiers": [ [ "species_10443035", "catalyst" ] ], "additional_components": [ "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P25228", "FBgn0005586", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P25228", "FBgn0005586" ] }, "reaction_10442860": { "compartment": "compartment_984", "id": "reaction_10442860", "reactome": "R-DME-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_210382", "species_29804", "species_74113" ], "products": [ "species_74126", "species_29404", "species_70106", "species_83910" ], "modifiers": [ [ "species_10442846", "catalyst" ], [ "species_10442858", "inhibitor" ] ], "additional_components": [ "FBgn0026438", "FBgn0032704" ] }, "reaction_10428262": { "compartment": "compartment_5460", "id": "reaction_10428262", "reactome": "R-DME-70609", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113522", "species_113521" ], "products": [ "species_113561", "species_113552" ], "modifiers": [ [ "species_10428259", "catalyst" ] ], "additional_components": [ "Q1RL13", "FBgn0261625" ] }, "reaction_10443028": { "compartment": "compartment_984", "id": "reaction_10443028", "reactome": "R-DME-210430", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443005", "species_74016" ], "products": [ "species_10443025", "species_210382", "species_10443011", "species_10442919", "species_10443003", "species_10442973", "species_10443021", "species_10443023" ], "modifiers": [ [ "species_10443005", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0031424", "FBgn0004574", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "species_74016", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q24547", "FBgn0013343" ] }, "reaction_10443008": { "compartment": "compartment_70101", "id": "reaction_10443008", "reactome": "R-DME-210426", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10442948", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10443005" ], "modifiers": [ [ "species_10442948", "catalyst" ], [ "species_10442988", "catalyst" ] ], "additional_components": [ "FBgn0013343", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q24547", "FBgn0013343", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "FBgn0025726" ] }, "reaction_10480942": { "compartment": "compartment_7660", "id": "reaction_10480942", "reactome": "R-DME-6791235", "name": "GADD45A binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480938", "species_10480365" ], "products": [ "species_10480940" ], "modifiers": [], "additional_components": [ "FBgn0000147", "FBgn0033153", "A1Z6W5", "FBgn0033153", "Q9VGF9", "FBgn0000147" ] }, "reaction_10485962": { "compartment": "compartment_70101", "id": "reaction_10485962", "reactome": "R-DME-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432002", "species_10437611" ], "products": [ "species_10485960" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P29310", "14-3-3zeta" ] }, "reaction_10485964": { "compartment": "compartment_70101", "id": "reaction_10485964", "reactome": "R-DME-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432000" ], "products": [ "species_10432002" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta" ] }, "reaction_10480369": { "compartment": "compartment_7660", "id": "reaction_10480369", "reactome": "R-DME-6791109", "name": "GADD45A binds PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427633", "species_10480365" ], "products": [ "species_10480367" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "FBgn0033153", "A1Z6W5", "FBgn0033153", "P17917", "FBgn0005655" ] }, "reaction_10432502": { "compartment": "compartment_70101", "id": "reaction_10432502", "reactome": "R-DME-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75973", "species_29364" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10432499", "catalyst" ] ], "additional_components": [ "FBgn0027583" ] }, "reaction_10498530": { "compartment": "compartment_70101", "id": "reaction_10498530", "reactome": "R-DME-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10469475" ], "products": [ "species_10489943" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10489892": { "compartment": "compartment_70101", "id": "reaction_10489892", "reactome": "R-DME-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489882", "species_10489888" ], "products": [ "species_10489890" ], "modifiers": [], "additional_components": [ "Q8IPM2", "FBgn0051528", "Q9VHX2", "FBgn0037538", "Q9VWD9", "FBgn0031057", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q8IPM2", "FBgn0051528", "Q9VHX2", "FBgn0037538", "Q9VWD9", "FBgn0031057" ] }, "reaction_10489638": { "compartment": "compartment_70101", "id": "reaction_10489638", "reactome": "R-DME-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489614", "species_10489598", "species_10489634" ], "products": [ "species_10489636" ], "modifiers": [], "additional_components": [ "O77277", "FBgn0025615", "FBgn0016975", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "O77277", "FBgn0025615", "Q24212", "FBgn0016975" ] }, "reaction_10489576": { "compartment": "compartment_876", "id": "reaction_10489576", "reactome": "R-DME-8863472", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489560", "species_10489572" ], "products": [ "species_10489574" ], "modifiers": [], "additional_components": [ "FBgn0000414", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414" ] }, "reaction_10489641": { "compartment": "compartment_70101", "id": "reaction_10489641", "reactome": "R-DME-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489636" ], "products": [ "species_10489614", "species_10477764", "species_10489634", "species_10489552" ], "modifiers": [ [ "species_10489636", "catalyst" ] ], "additional_components": [ "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "O77277", "FBgn0025615", "Q24212", "FBgn0016975", "O77277", "FBgn0025615", "FBgn0032725", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "FBgn0016975", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "O77277", "FBgn0025615", "Q24212", "FBgn0016975" ] }, "reaction_10489963": { "compartment": "compartment_876", "id": "reaction_10489963", "reactome": "R-DME-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489959", "species_10489888" ], "products": [ "species_10489961" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VS85", "FBgn0028582", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341" ] }, "reaction_10489643": { "compartment": "compartment_70101", "id": "reaction_10489643", "reactome": "R-DME-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477764", "species_10489552" ], "products": [ "species_10489598" ], "modifiers": [], "additional_components": [ "FBgn0032725", "FBgn0016975", "FBgn0016975" ] }, "reaction_10489969": { "compartment": "compartment_876", "id": "reaction_10489969", "reactome": "R-DME-8866283", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489853", "species_10489365" ], "products": [ "species_10489965" ], "modifiers": [ [ "species_10489967", "inhibitor" ] ], "additional_components": [ "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q8IPM2", "FBgn0051528", "Q9VHX2", "FBgn0037538", "Q9VWD9", "FBgn0031057", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582" ] }, "reaction_10490099": { "compartment": "compartment_876", "id": "reaction_10490099", "reactome": "R-DME-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490093", "species_10490091" ], "products": [ "species_10490097" ], "modifiers": [], "additional_components": [ "FBgn0086372", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372" ] }, "reaction_10489558": { "compartment": "compartment_876", "id": "reaction_10489558", "reactome": "R-DME-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489547", "species_10489552" ], "products": [ "species_10489556" ], "modifiers": [], "additional_components": [ "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "FBgn0016975", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090" ] }, "reaction_10489945": { "compartment": "compartment_876", "id": "reaction_10489945", "reactome": "R-DME-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469475", "species_10489939" ], "products": [ "species_10489941" ], "modifiers": [ [ "species_10489943", "inhibitor" ] ], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10489595": { "compartment": "compartment_876", "id": "reaction_10489595", "reactome": "R-DME-8863718", "name": "AGFG1 binds VAMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489591", "species_10489589" ], "products": [ "species_10489593" ], "modifiers": [], "additional_components": [ "FBgn0266186", "FBgn0020304", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186" ] }, "reaction_10489855": { "compartment": "compartment_876", "id": "reaction_10489855", "reactome": "R-DME-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489851", "species_10474367" ], "products": [ "species_10489853" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10484330": { "compartment": "compartment_7660", "id": "reaction_10484330", "reactome": "R-DME-6799246", "name": "CHEK1 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427808", "species_29358" ], "products": [ "species_113582", "species_10427813" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0261278" ] }, "reaction_10438565": { "compartment": "compartment_7660", "id": "reaction_10438565", "reactome": "R-DME-176116", "name": "Recruitment and activation of Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438550" ], "products": [ "species_113582", "species_10427785" ], "modifiers": [ [ "species_10438562", "catalyst" ] ], "additional_components": [ "FBgn0261278", "FBgn0261278", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367" ] }, "reaction_10432380": { "compartment": "compartment_7660", "id": "reaction_10432380", "reactome": "R-DME-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10431972" ], "products": [ "species_113582", "species_10431980" ], "modifiers": [ [ "species_10427797", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0019686" ] }, "reaction_10497068": { "compartment": "compartment_70101", "id": "reaction_10497068", "reactome": "R-DME-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431980" ], "products": [ "species_10431988" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10498000": { "compartment": "compartment_17938", "id": "reaction_10498000", "reactome": "R-DME-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10497993" ], "products": [ "species_10497997", "species_29420" ], "modifiers": [ [ "species_10497993", "catalyst" ] ], "additional_components": [ "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "species_29468", "species_29468", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "species_29468" ] }, "reaction_10498113": { "compartment": "compartment_17938", "id": "reaction_10498113", "reactome": "R-DME-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497982" ], "products": [ "species_29372", "species_10497986" ], "modifiers": [ [ "species_10497982", "catalyst" ], [ "species_10498111", "catalyst" ] ], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438", "Q9VS33", "FBgn0261111", "E3CTN7", "FBgn0036684" ] }, "reaction_10498116": { "compartment": "compartment_17938", "id": "reaction_10498116", "reactome": "R-DME-9645608", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497995", "species_10436975" ], "products": [ "species_10498002" ], "modifiers": [], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10497989": { "compartment": "compartment_17938", "id": "reaction_10497989", "reactome": "R-DME-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497982", "species_29420" ], "products": [ "species_29438", "species_10497986" ], "modifiers": [ [ "species_10497982", "catalyst" ] ], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438" ] }, "reaction_10498009": { "compartment": "compartment_17938", "id": "reaction_10498009", "reactome": "R-DME-9640195", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498004" ], "products": [ "species_29372", "species_10498006" ], "modifiers": [ [ "species_10498004", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VND8", "Rheb", "species_29438", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10498124": { "compartment": "compartment_17938", "id": "reaction_10498124", "reactome": "R-DME-9646468", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436956", "species_10498002" ], "products": [ "species_10498004" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29438", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10437161": { "compartment": "compartment_70616", "id": "reaction_10437161", "reactome": "R-DME-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437154" ], "products": [ "species_166216", "species_10437150" ], "modifiers": [], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872" ] }, "reaction_10437159": { "compartment": "compartment_70616", "id": "reaction_10437159", "reactome": "R-DME-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_166213", "species_10437150" ], "products": [ "species_10437152" ], "modifiers": [], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213" ] }, "reaction_10437157": { "compartment": "compartment_70616", "id": "reaction_10437157", "reactome": "R-DME-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437152" ], "products": [ "species_10437154" ], "modifiers": [ [ "species_10437152", "catalyst" ] ], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213" ] }, "reaction_10437560": { "compartment": "compartment_70616", "id": "reaction_10437560", "reactome": "R-DME-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10437150", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_113592", "species_29370", "species_29420", "species_29438" ] }, "reaction_10442079": { "compartment": "compartment_70101", "id": "reaction_10442079", "reactome": "R-DME-202960", "name": "Caspase mediated cleavage of C-IAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442065" ], "products": [ "species_10442071", "species_10442077" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "Q9XYF4", "FBgn0026404" ] }, "reaction_10497056": { "compartment": "compartment_7660", "id": "reaction_10497056", "reactome": "R-DME-9029680", "name": "Caspase-7 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434869" ], "products": [ "species_10444173" ], "modifiers": [], "additional_components": [ "Q9VET9", "FBgn0028381", "Q9VET9", "FBgn0028381" ] }, "reaction_10441599": { "compartment": "compartment_70101", "id": "reaction_10441599", "reactome": "R-DME-201608", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441593" ], "products": [ "species_10441595", "species_10441597" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0263391", "FBgn0263391", "FBgn0263391", "Q9XYF4", "FBgn0026404" ] }, "reaction_10442090": { "compartment": "compartment_70101", "id": "reaction_10442090", "reactome": "R-DME-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442084" ], "products": [ "species_10442086", "species_10442088" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0036372", "FBgn0036372", "FBgn0036372", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441658": { "compartment": "compartment_70101", "id": "reaction_10441658", "reactome": "R-DME-201637", "name": "Caspase-mediated cleavage of plectin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441643" ], "products": [ "species_10441645", "species_10441647" ], "modifiers": [ [ "species_10441655", "catalyst" ] ], "additional_components": [ "FBgn0013733", "FBgn0013733", "FBgn0013733", "O01382", "FBgn0019972" ] }, "reaction_10442101": { "compartment": "compartment_70101", "id": "reaction_10442101", "reactome": "R-DME-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442095" ], "products": [ "species_10442097", "species_10442099" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0250789", "FBgn0250789", "FBgn0250789", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441621": { "compartment": "compartment_70101", "id": "reaction_10441621", "reactome": "R-DME-201629", "name": "Caspase-mediated cleavage of Tau", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441615" ], "products": [ "species_10441617", "species_10441619" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0266579", "FBgn0266579", "FBgn0266579", "Q9XYF4", "FBgn0026404" ] }, "reaction_10443560": { "compartment": "compartment_7660", "id": "reaction_10443560", "reactome": "R-DME-264865", "name": "Caspase-mediated cleavage of Lamin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443537" ], "products": [ "species_10443543", "species_10443549" ], "modifiers": [ [ "species_10443557", "catalyst" ] ], "additional_components": [ "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q9VET9", "FBgn0028381" ] }, "reaction_10497066": { "compartment": "compartment_13231", "id": "reaction_10497066", "reactome": "R-DME-9029690", "name": "Caspase-6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497064" ], "products": [ "species_10443557" ], "modifiers": [], "additional_components": [ "Q9VET9", "FBgn0028381", "Q9VET9", "FBgn0028381" ] }, "reaction_10443568": { "compartment": "compartment_7660", "id": "reaction_10443568", "reactome": "R-DME-264871", "name": "Caspase-mediated cleavage of Lamin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443562" ], "products": [ "species_10443564", "species_10443566" ], "modifiers": [ [ "species_10443557", "catalyst" ] ], "additional_components": [ "FBgn0002525", "FBgn0002525", "FBgn0002525", "Q9VET9", "FBgn0028381" ] }, "reaction_10444150": { "compartment": "compartment_12045", "id": "reaction_10444150", "reactome": "R-DME-351894", "name": "Caspase mediated cleavage of BAP31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444141" ], "products": [ "species_10444145", "species_10444147", "species_10444143" ], "modifiers": [ [ "species_10444126", "catalyst" ] ], "additional_components": [ "FBgn0035165", "FBgn0035165", "FBgn0035165", "FBgn0035165", "O01382", "FBgn0019972" ] }, "reaction_10444118": { "compartment": "compartment_70101", "id": "reaction_10444118", "reactome": "R-DME-351849", "name": "Caspase-mediated cleavage of Etk", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444112" ], "products": [ "species_10444114", "species_10444116" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0003502", "FBgn0003502", "FBgn0003502", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441588": { "compartment": "compartment_70101", "id": "reaction_10441588", "reactome": "R-DME-201603", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441582" ], "products": [ "species_10441584", "species_10441586" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0259680", "FBgn0259680", "FBgn0259680", "Q9XYF4", "FBgn0026404" ] }, "reaction_10443314": { "compartment": "compartment_70101", "id": "reaction_10443314", "reactome": "R-DME-212552", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434441" ], "products": [ "species_10443312", "species_10443310" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0259680", "FBgn0259680", "FBgn0259680", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444176": { "compartment": "compartment_7660", "id": "reaction_10444176", "reactome": "R-DME-351936", "name": "Caspase-mediated cleavage of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438600" ], "products": [ "species_10444163", "species_10444165" ], "modifiers": [ [ "species_10444173", "catalyst" ] ], "additional_components": [ "FBgn0052251", "FBgn0052251", "FBgn0052251", "Q9VET9", "FBgn0028381" ] }, "reaction_10444238": { "compartment": "compartment_7660", "id": "reaction_10444238", "reactome": "R-DME-352268", "name": "Cleavage of Satb1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444232" ], "products": [ "species_10444234", "species_10444236" ], "modifiers": [ [ "species_10443557", "catalyst" ] ], "additional_components": [ "FBgn0020307", "FBgn0020307", "FBgn0020307", "Q9VET9", "FBgn0028381" ] }, "reaction_10442059": { "compartment": "compartment_70101", "id": "reaction_10442059", "reactome": "R-DME-202947", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442045" ], "products": [ "species_10442051", "species_10442057" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9VAS9", "FBgn0015589", "Q9Y1T2", "Apc2", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441610": { "compartment": "compartment_70101", "id": "reaction_10441610", "reactome": "R-DME-201611", "name": "Caspase-mediated cleavage of Rock-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604" ], "products": [ "species_10441606", "species_10441608" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0026181", "FBgn0026181", "FBgn0026181", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441669": { "compartment": "compartment_70101", "id": "reaction_10441669", "reactome": "R-DME-201640", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441663" ], "products": [ "species_10441665", "species_10441667" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0031633", "FBgn0031633", "FBgn0031633", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444035": { "compartment": "compartment_70101", "id": "reaction_10444035", "reactome": "R-DME-350651", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444029" ], "products": [ "species_10444033", "species_10444031" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0266465", "FBgn0266465", "FBgn0266465", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444161": { "compartment": "compartment_70101", "id": "reaction_10444161", "reactome": "R-DME-351901", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444152" ], "products": [ "species_10444154", "species_10444156" ], "modifiers": [ [ "species_10444158", "catalyst" ] ], "additional_components": [ "FBgn0266465", "FBgn0266465", "FBgn0266465", "Q9XYF4", "FBgn0026404", "Q9VET9", "FBgn0028381" ] }, "reaction_10442109": { "compartment": "compartment_70101", "id": "reaction_10442109", "reactome": "R-DME-202969", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442103" ], "products": [ "species_10442105", "species_10442107" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "Q9XYF4", "FBgn0026404" ] }, "reaction_10441580": { "compartment": "compartment_876", "id": "reaction_10441580", "reactome": "R-DME-201595", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441575" ], "products": [ "species_10441577" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0260799", "FBgn0260799", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441641": { "compartment": "compartment_70101", "id": "reaction_10441641", "reactome": "R-DME-201636", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441637" ], "products": [ "species_10441639" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0013733", "FBgn0013733", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444136": { "compartment": "compartment_70101", "id": "reaction_10444136", "reactome": "R-DME-351876", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444130" ], "products": [ "species_10444132", "species_10444134" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0014037", "FBgn0014037", "FBgn0014037", "Q9XYF4", "FBgn0026404" ] }, "reaction_10442039": { "compartment": "compartment_876", "id": "reaction_10442039", "reactome": "R-DME-202939", "name": "Caspase-mediated cleavage of E-Cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442033" ], "products": [ "species_10442035", "species_10442037" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0262018", "FBgn0262018", "FBgn0262018", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441632": { "compartment": "compartment_70101", "id": "reaction_10441632", "reactome": "R-DME-201630", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441626" ], "products": [ "species_10441628", "species_10441630" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0263198", "FBgn0263198", "FBgn0263198", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444189": { "compartment": "compartment_70101", "id": "reaction_10444189", "reactome": "R-DME-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444185" ], "products": [ "species_10444187" ], "modifiers": [ [ "species_10444143", "catalyst" ] ], "additional_components": [ "FBgn0026479", "FBgn0026479", "FBgn0035165" ] }, "reaction_10444180": { "compartment": "compartment_13231", "id": "reaction_10444180", "reactome": "R-DME-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444154" ], "products": [ "species_10444178" ], "modifiers": [], "additional_components": [ "FBgn0266465", "FBgn0266465" ] }, "reaction_10443148": { "compartment": "compartment_13231", "id": "reaction_10443148", "reactome": "R-DME-211206", "name": "Translocation of DFF to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443134" ], "products": [ "species_10443146" ], "modifiers": [], "additional_components": [ "O18388", "FBgn0262743", "O76521", "FBgn0024889", "Q9V3H0", "FBgn0028406", "O18388", "FBgn0262743", "O76521", "FBgn0024889", "Q9V3H0", "FBgn0028406" ] }, "reaction_10443158": { "compartment": "compartment_13231", "id": "reaction_10443158", "reactome": "R-DME-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434841" ], "products": [ "species_10443156" ], "modifiers": [], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q9XYF4", "FBgn0026404" ] }, "reaction_10443126": { "compartment": "compartment_7660", "id": "reaction_10443126", "reactome": "R-DME-211193", "name": "Homodimerization of DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443122" ], "products": [ "species_10443124" ], "modifiers": [], "additional_components": [ "FBgn0028406", "Q9V3H0", "FBgn0028406" ] }, "reaction_10443924": { "compartment": "compartment_7660", "id": "reaction_10443924", "reactome": "R-DME-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443920", "species_29428" ], "products": [ "species_10443922" ], "modifiers": [], "additional_components": [ "Q24537", "Dsp1", "E1JIT5", "FBgn0038979", "Q9VCZ5", "FBgn0038978", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "E1JIT5", "FBgn0038979", "Q9VCZ5", "FBgn0038978", "Q05783", "FBgn0004362" ] }, "reaction_10444128": { "compartment": "compartment_70101", "id": "reaction_10444128", "reactome": "R-DME-351863", "name": "Translocation of active caspase-8 to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441655" ], "products": [ "species_10444126" ], "modifiers": [], "additional_components": [ "O01382", "FBgn0019972", "O01382", "FBgn0019972" ] }, "reaction_10444436": { "compartment": "compartment_70101", "id": "reaction_10444436", "reactome": "R-DME-373705", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444421" ], "products": [ "species_10444433", "species_10444427" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "Q9XYF4", "FBgn0026404" ] }, "reaction_10497776": { "compartment": "compartment_70101", "id": "reaction_10497776", "reactome": "R-DME-9627369", "name": "SEPT4 binds XIAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497772", "species_10434883" ], "products": [ "species_10497774" ], "modifiers": [], "additional_components": [ "Q0KHR7", "FBgn0259923", "Q24306", "Diap1", "Q24307", "Diap2", "Q0KHR7", "FBgn0259923", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10497768": { "compartment": "compartment_70101", "id": "reaction_10497768", "reactome": "R-DME-9627104", "name": "XIAP binds CASP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434883", "species_10434841" ], "products": [ "species_10497766" ], "modifiers": [], "additional_components": [ "Q24306", "Diap1", "Q24307", "Diap2", "Q9XYF4", "FBgn0026404", "Q9XYF4", "FBgn0026404", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10497770": { "compartment": "compartment_70101", "id": "reaction_10497770", "reactome": "R-DME-9627107", "name": "XIAP binds CASP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434883", "species_10434869" ], "products": [ "species_10434885" ], "modifiers": [], "additional_components": [ "Q24306", "Diap1", "Q24307", "Diap2", "Q9VET9", "FBgn0028381", "Q9VET9", "FBgn0028381", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10486228": { "compartment": "compartment_70101", "id": "reaction_10486228", "reactome": "R-DME-6805811", "name": "Release of SEPT4 from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486224" ], "products": [ "species_10486226" ], "modifiers": [], "additional_components": [ "FBgn0259923", "FBgn0259923" ] }, "reaction_10434873": { "compartment": "compartment_17906", "id": "reaction_10434873", "reactome": "R-DME-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434871" ], "products": [ "species_10434846" ], "modifiers": [], "additional_components": [ "FBgn0284248", "FBgn0284248" ] }, "reaction_10433151": { "compartment": "compartment_5460", "id": "reaction_10433151", "reactome": "R-DME-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433190": { "compartment": "compartment_5460", "id": "reaction_10433190", "reactome": "R-DME-77309", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77253" ], "products": [ "species_77308", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10468301": { "compartment": "compartment_7660", "id": "reaction_10468301", "reactome": "R-DME-3318415", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467826", "species_113560" ], "products": [ "species_2485002", "species_10468296" ], "modifiers": [ [ "species_10437332", "catalyst" ] ], "additional_components": [ "FBgn0001198", "FBgn0001198", "FBgn0265193" ] }, "reaction_10468772": { "compartment": "compartment_7660", "id": "reaction_10468772", "reactome": "R-DME-3662335", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468720", "species_113560" ], "products": [ "species_2485002", "species_10468769" ], "modifiers": [ [ "species_10458126", "catalyst" ] ], "additional_components": [ "FBgn0261617" ] }, "reaction_10472691": { "compartment": "compartment_7660", "id": "reaction_10472691", "reactome": "R-DME-5579018", "name": "NCOA1(868-1441) binds PAX3(1-319)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472670", "species_10472687" ], "products": [ "species_10472689" ], "modifiers": [], "additional_components": [ "FBgn0041092", "P09083", "FBgn0001147", "P09082", "FBgn0001148", "P06601", "FBgn0003145", "P09083", "FBgn0001147", "P09082", "FBgn0001148", "P06601", "FBgn0003145", "M9ND53", "FBgn0041092" ] }, "reaction_10441327": { "compartment": "compartment_70101", "id": "reaction_10441327", "reactome": "R-DME-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441315", "species_113592" ], "products": [ "species_29370", "species_10441322" ], "modifiers": [ [ "species_10441324", "catalyst" ] ], "additional_components": [ "A1Z784", "FBgn0033246", "species_266099", "A1Z784", "FBgn0033246", "species_266099", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357" ] }, "reaction_10436920": { "compartment": "compartment_876", "id": "reaction_10436920", "reactome": "R-DME-165026", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10436917", "catalyst" ] ], "additional_components": [ "Q9VCA0", "FBgn0039178", "Q9VNW8", "FBgn0037144", "Q961R9", "FBgn0038407", "Q9VEY1", "FBgn0038404", "A2RVG5", "FBgn0063649", "Q9VD40", "FBgn0038938", "Q9VNX2", "FBgn0037140" ] }, "reaction_10441335": { "compartment": "compartment_17927", "id": "reaction_10441335", "reactome": "R-DME-200424", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_201023", "species_201034" ], "products": [ "species_549207", "species_201050" ], "modifiers": [ [ "species_10441332", "catalyst" ] ], "additional_components": [ "FBgn0019830" ] }, "reaction_10441286": { "compartment": "compartment_70616", "id": "reaction_10441286", "reactome": "R-DME-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10441283", "catalyst" ] ], "additional_components": [ "FBgn0035383" ] }, "reaction_10490057": { "compartment": "compartment_70101", "id": "reaction_10490057", "reactome": "R-DME-8866941", "name": "MID1IP1 binds THRSP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432448", "species_10432446" ], "products": [ "species_10432450" ], "modifiers": [], "additional_components": [ "FBgn0035087", "FBgn0035087", "Q9W0X5", "FBgn0035087" ] }, "reaction_10432452": { "compartment": "compartment_70101", "id": "reaction_10432452", "reactome": "R-DME-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10432440", "catalyst" ], [ "species_10432450", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "species_266099", "A1Z784", "FBgn0033246", "Q9W0X5", "FBgn0035087" ] }, "reaction_10491438": { "compartment": "compartment_70101", "id": "reaction_10491438", "reactome": "R-DME-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10441315", "catalyst" ], [ "species_10432450", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "A1Z784", "FBgn0033246", "species_266099", "Q9W0X5", "FBgn0035087" ] }, "reaction_10465132": { "compartment": "compartment_70101", "id": "reaction_10465132", "reactome": "R-DME-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10429065", "catalyst" ] ], "additional_components": [ "species_1562550", "P46415", "FBgn0011768" ] }, "reaction_10465049": { "compartment": "compartment_70101", "id": "reaction_10465049", "reactome": "R-DME-2161195", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161194" ], "products": [ "species_2161176", "species_2161175" ], "modifiers": [ [ "species_10465044", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VHH7", "FBgn0037661" ] }, "reaction_10465129": { "compartment": "compartment_70101", "id": "reaction_10465129", "reactome": "R-DME-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10431536", "catalyst" ] ], "additional_components": [ "Q9VWV5", "FBgn0052549", "species_29926" ] }, "reaction_10469582": { "compartment": "compartment_70101", "id": "reaction_10469582", "reactome": "R-DME-4084989", "name": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_4085390" ], "products": [ "species_428633", "species_29372" ], "modifiers": [ [ "species_10469579", "catalyst" ] ], "additional_components": [ "species_29926", "Q9W481", "FBgn0029801" ] }, "reaction_10469572": { "compartment": "compartment_70101", "id": "reaction_10469572", "reactome": "R-DME-4084976", "name": "NANS converts ManNAc-6-P to Neu5Ac-9-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_4085225", "species_29492" ], "products": [ "species_29372", "species_4085390" ], "modifiers": [ [ "species_10469569", "catalyst" ] ], "additional_components": [ "FBgn0038045" ] }, "reaction_10469586": { "compartment": "compartment_20699", "id": "reaction_10469586", "reactome": "R-DME-4085033", "name": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_4086285" ], "products": [ "species_727810", "species_4086294" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "FBgn0035050" ] }, "reaction_10475581": { "compartment": "compartment_70101", "id": "reaction_10475581", "reactome": "R-DME-5668545", "name": "NIK autophosphorylates on T559", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10446829" ], "products": [ "species_29370", "species_10475579" ], "modifiers": [ [ "species_10446829", "catalyst" ] ], "additional_components": [ "FBgn0024329", "FBgn0024329", "FBgn0024329" ] }, "reaction_10433321": { "compartment": "compartment_7660", "id": "reaction_10433321", "reactome": "R-DME-83805", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433315", "species_10432757" ], "products": [ "species_10433319" ], "modifiers": [], "additional_components": [ "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463", "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512" ] }, "reaction_10433317": { "compartment": "compartment_7660", "id": "reaction_10433317", "reactome": "R-DME-83790", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432662", "species_10433311" ], "products": [ "species_10433315" ], "modifiers": [], "additional_components": [ "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512" ] }, "reaction_10433313": { "compartment": "compartment_7660", "id": "reaction_10433313", "reactome": "R-DME-83788", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432691", "species_83747" ], "products": [ "species_10433311" ], "modifiers": [], "additional_components": [ "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390" ] }, "reaction_10443033": { "compartment": "compartment_984", "id": "reaction_10443033", "reactome": "R-DME-210439", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382" ], "products": [ "species_29404" ], "modifiers": [ [ "species_10443030", "catalyst" ] ], "additional_components": [] }, "reaction_10428246": { "compartment": "compartment_70101", "id": "reaction_10428246", "reactome": "R-DME-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_31633" ], "products": [ "species_29372", "species_29370", "species_29472" ], "modifiers": [ [ "species_10428243", "catalyst" ] ], "additional_components": [ "P20478", "FBgn0001145", "P20477", "FBgn0001142" ] }, "reaction_10464591": { "compartment": "compartment_12045", "id": "reaction_10464591", "reactome": "R-DME-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10446277", "catalyst" ] ], "additional_components": [ "FBgn0039890" ] }, "reaction_10464593": { "compartment": "compartment_17957", "id": "reaction_10464593", "reactome": "R-DME-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10453288", "catalyst" ] ], "additional_components": [ "Q9VV87", "FBgn0260960", "Q9VHX7", "FBgn0037534", "Q6NN18", "FBgn0034382", "Q9VCY6", "FBgn0038986", "Q9VH59", "FBgn0037761", "Q4V3H4", "FBgn0037764", "Q9VCY5", "FBgn0053110", "Q9VH58", "FBgn0037762", "A1ZBD2", "FBgn0034383", "Q9VCT3", "FBgn0039030", "Q9VH57", "FBgn0037763", "Q95T98", "FBgn0051523", "Q9VH55", "FBgn0037765", "Q8SXD1", "FBgn0050008", "Q9VCZ0", "FBgn0038983", "Q8IMY2", "FBgn0051141", "Q9VCY7", "FBgn0260942" ] }, "reaction_214880": { "compartment": "compartment_70101", "id": "reaction_214880", "reactome": "R-DME-214880", "name": "DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "In dorsoventral patterning in the embryo, Dorsal (DL) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.", "reactants": [ "species_214746", "species_214759" ], "products": [ "species_214758" ], "modifiers": [], "additional_components": [ "P15330", "dl", "Q03017", "phospho-cact", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P15330", "dl", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214857": { "compartment": "compartment_70101", "id": "reaction_214857", "reactome": "R-DME-214857", "name": "DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "The Dorsal (DL) and Dorsal-related immunity factor (DIF) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.", "reactants": [ "species_206862", "species_206693" ], "products": [ "species_214744" ], "modifiers": [], "additional_components": [ "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL" ] }, "reaction_10467071": { "compartment": "compartment_70101", "id": "reaction_10467071", "reactome": "R-DME-2744361", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10467068", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9VUM6", "FBgn0036491", "Q9VRW4", "FBgn0035696", "Q9VUM7", "FBgn0036492" ] }, "reaction_10498689": { "compartment": "compartment_70101", "id": "reaction_10498689", "reactome": "R-DME-9701141", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10468206", "catalyst" ] ], "additional_components": [ "FBgn0086693" ] }, "reaction_10468221": { "compartment": "compartment_70101", "id": "reaction_10468221", "reactome": "R-DME-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10468218", "catalyst" ] ], "additional_components": [ "Q9VJJ7", "FBgn0032593", "Q9W3W0", "FBgn0086693", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "Q9VW35", "FBgn0261361", "Q7Z020", "FBgn0035934", "A8DYE2", "FBgn0265194" ] }, "reaction_10498686": { "compartment": "compartment_70101", "id": "reaction_10498686", "reactome": "R-DME-9701055", "name": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10498683", "catalyst" ] ], "additional_components": [ "Q7Z020", "FBgn0035934" ] }, "reaction_10498213": { "compartment": "compartment_876", "id": "reaction_10498213", "reactome": "R-DME-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10498211" ], "products": [ "species_10466252" ], "modifiers": [], "additional_components": [ "Q9VJI4", "FBgn0032602", "Q9VJI4", "FBgn0032602", "species_163953" ] }, "reaction_10466969": { "compartment": "compartment_70101", "id": "reaction_10466969", "reactome": "R-DME-2730959", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2730999", "species_70106" ], "products": [ "species_428040", "species_352022" ], "modifiers": [ [ "species_10466966", "catalyst" ] ], "additional_components": [ "Q7JZ25", "FBgn0033755", "Q95SH7", "FBgn0035440" ] }, "reaction_10466773": { "compartment": "compartment_70101", "id": "reaction_10466773", "reactome": "R-DME-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10466770", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "M9PI24", "FBgn0036235", "O97132", "FBgn0000152", "Q9V416", "FBgn0028879" ] }, "reaction_10466997": { "compartment": "compartment_70101", "id": "reaction_10466997", "reactome": "R-DME-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10466992", "catalyst" ] ], "additional_components": [ "FBgn0051116" ] }, "reaction_10466803": { "compartment": "compartment_70101", "id": "reaction_10466803", "reactome": "R-DME-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_74722", "species_352022" ], "modifiers": [ [ "species_10466798", "catalyst" ] ], "additional_components": [ "FBgn0036566" ] }, "reaction_10467123": { "compartment": "compartment_17927", "id": "reaction_10467123", "reactome": "R-DME-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_2889081" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10467120", "catalyst" ] ], "additional_components": [ "species_74113", "species_425810", "species_425810", "species_74113", "FBgn0031865" ] }, "reaction_10466257": { "compartment": "compartment_70101", "id": "reaction_10466257", "reactome": "R-DME-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10466252", "catalyst" ], [ "species_10466255", "inhibitor" ], [ "species_2672379", "inhibitor" ], [ "species_2672383", "inhibitor" ] ], "additional_components": [ "Q9VJI4", "FBgn0032602", "species_163953", "FBgn0032602" ] }, "reaction_10467025": { "compartment": "compartment_70101", "id": "reaction_10467025", "reactome": "R-DME-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10467022", "catalyst" ] ], "additional_components": [ "FBgn0015558" ] }, "reaction_10489584": { "compartment": "compartment_876", "id": "reaction_10489584", "reactome": "R-DME-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489580", "species_10466252" ], "products": [ "species_10489582" ], "modifiers": [], "additional_components": [ "Q9VZA4", "FBgn0260657", "Q9VJI4", "FBgn0032602", "species_163953", "Q9VJI4", "FBgn0032602", "species_163953", "Q9VZA4", "FBgn0260657" ] }, "reaction_10467118": { "compartment": "compartment_984", "id": "reaction_10467118", "reactome": "R-DME-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10467115", "catalyst" ] ], "additional_components": [ "FBgn0031865" ] }, "reaction_10467020": { "compartment": "compartment_70101", "id": "reaction_10467020", "reactome": "R-DME-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10467017", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9W5A5", "FBgn0261444", "Q9U6L4", "FBgn0015558" ] }, "reaction_10466793": { "compartment": "compartment_70101", "id": "reaction_10466793", "reactome": "R-DME-2730664", "name": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10466790", "catalyst" ], [ "species_74016", "inhibitor" ] ], "additional_components": [ "Q9VDY5", "FBgn0038693", "A8JUW5", "FBgn0002917", "Q9VB11", "FBgn0039536" ] }, "reaction_10467080": { "compartment": "compartment_70101", "id": "reaction_10467080", "reactome": "R-DME-2752067", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627" ], "products": [ "species_425425" ], "modifiers": [ [ "species_10467068", "catalyst" ] ], "additional_components": [ "Q9VUM6", "FBgn0036491", "Q9VRW4", "FBgn0035696", "Q9VUM7", "FBgn0036492" ] }, "reaction_10466592": { "compartment": "compartment_984", "id": "reaction_10466592", "reactome": "R-DME-2672334", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10466589", "catalyst" ], [ "species_2672379", "inhibitor" ] ], "additional_components": [ "Q9W2B5", "FBgn0085398", "Q9W250", "FBgn0034730", "Q9VZN1", "FBgn0035458", "Q9VS73", "FBgn0035785", "Q9VME9", "FBgn0031802", "Q9VME8", "FBgn0031803", "Q9VL88", "FBgn0265001", "Q9VL84", "FBgn0065109", "Q9VBF6", "FBgn0039424", "Q9VAJ7", "FBgn0039675", "Q9VAJ6", "FBgn0039676", "Q9VAJ5", "FBgn0039677", "Q9VAJ3", "FBgn0039679", "Q9V9Y5", "FBgn0039839", "Q8MLR6", "FBgn0050181", "Q8IMV2", "FBgn0051105", "Q86LH3", "FBgn0034489", "Q86LH1", "FBgn0065110", "Q86LG9", "FBgn0053508", "Q86LG7", "FBgn0065108", "Q86LG1", "FBgn0030795", "Q7KTW2", "FBgn0053289", "Q7KT94", "FBgn0020258", "Q0KHW3", "FBgn0052792", "O61365", "FBgn0024319", "A8JV41", "FBgn0030844", "A8JPJ8", "FBgn0051065", "A8DYP1", "FBgn0034965", "A1Z6S4", "FBgn0053349" ] }, "reaction_10489010": { "compartment": "compartment_17938", "id": "reaction_10489010", "reactome": "R-DME-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10488963" ], "products": [ "species_29372", "species_10489003" ], "modifiers": [ [ "species_10488963", "catalyst" ], [ "species_10489008", "catalyst" ] ], "additional_components": [ "O76742", "FBgn0015795", "species_29438", "O76742", "FBgn0015795", "species_29420", "O76742", "FBgn0015795", "species_29438", "FBgn0031233" ] }, "reaction_10488981": { "compartment": "compartment_262783", "id": "reaction_10488981", "reactome": "R-DME-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488970", "species_10488977" ], "products": [ "species_10488979" ], "modifiers": [], "additional_components": [ "FBgn0037917", "species_29438", "P40946", "FBgn0013750", "species_29438", "P40946", "FBgn0013750", "Q9VGL8", "FBgn0037917" ] }, "reaction_10488999": { "compartment": "compartment_20699", "id": "reaction_10488999", "reactome": "R-DME-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488142", "species_10488995" ], "products": [ "species_10488997" ], "modifiers": [], "additional_components": [ "O18334", "Rab6", "species_29438", "FBgn0035879", "A8JNN5", "FBgn0035879", "O18334", "Rab6", "species_29438" ] }, "reaction_10488968": { "compartment": "compartment_17938", "id": "reaction_10488968", "reactome": "R-DME-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10488963" ], "products": [ "species_29372", "species_10488965" ], "modifiers": [ [ "species_10488963", "catalyst" ] ], "additional_components": [ "O76742", "FBgn0015795", "species_29438", "O76742", "FBgn0015795", "species_29420", "O76742", "FBgn0015795", "species_29438" ] }, "reaction_10488924": { "compartment": "compartment_24339", "id": "reaction_10488924", "reactome": "R-DME-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10488901" ], "products": [ "species_29372", "species_10488903" ], "modifiers": [ [ "species_10488901", "catalyst" ], [ "species_10488922", "catalyst" ] ], "additional_components": [ "Q9W5X0", "FBgn0031090", "species_29438", "Q9W5X0", "FBgn0031090", "species_29420", "Q9W5X0", "FBgn0031090", "species_29438", "Q9VSM8", "FBgn0035916", "Q9VIH7", "FBgn0032901", "Q9VGL8", "FBgn0037917" ] }, "reaction_10488990": { "compartment": "compartment_70101", "id": "reaction_10488990", "reactome": "R-DME-8854302", "name": "TBC1D7 binds the TSC1-TSC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488986", "species_10436942" ], "products": [ "species_10488988" ], "modifiers": [], "additional_components": [ "FBgn0039158", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VCC4", "FBgn0039158" ] }, "reaction_10489038": { "compartment": "compartment_437051", "id": "reaction_10489038", "reactome": "R-DME-8854604", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10489028" ], "products": [ "species_29372", "species_10489030" ], "modifiers": [ [ "species_10489028", "catalyst" ], [ "species_10489036", "catalyst" ] ], "additional_components": [ "Q7KY04", "FBgn0016701", "species_29438", "Q7KY04", "FBgn0016701", "species_29420", "Q7KY04", "FBgn0016701", "species_29438", "FBgn0032249" ] }, "reaction_10489022": { "compartment": "compartment_5683628", "id": "reaction_10489022", "reactome": "R-DME-8854588", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489018", "species_10476330" ], "products": [ "species_10489020" ], "modifiers": [], "additional_components": [ "FBgn0034009", "FBgn0052672", "Q9W2S2", "FBgn0052672", "Q5BI03", "FBgn0034009" ] }, "reaction_10488959": { "compartment": "compartment_171062", "id": "reaction_10488959", "reactome": "R-DME-8854222", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488927", "species_10488955" ], "products": [ "species_10488957" ], "modifiers": [], "additional_components": [ "FBgn0020620", "species_29438", "Q9V3I2", "FBgn0014010", "Q9W329", "FBgn0030141", "Q9W0H9", "FBgn0262937", "species_29438", "Q9V3I2", "FBgn0014010", "Q9W329", "FBgn0030141", "Q9W0H9", "FBgn0262937", "A1Z9K4", "FBgn0020620" ] }, "reaction_10479983": { "compartment": "compartment_5460", "id": "reaction_10479983", "reactome": "R-DME-6788556", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436354", "species_10477522", "species_76629", "species_10436347" ], "products": [ "species_10477520", "species_10436356", "species_10436349" ], "modifiers": [], "additional_components": [ "FBgn0030853", "Q9V9M8", "FBgn0032986", "FBgn0031771", "FBgn0032986", "Q9VX36", "FBgn0030853", "Q9VMI3", "FBgn0031771", "species_76629" ] }, "reaction_10485760": { "compartment": "compartment_5460", "id": "reaction_10485760", "reactome": "R-DME-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436528", "species_10436547", "species_10484249", "species_10436554", "species_10436540" ], "products": [ "species_10484251" ], "modifiers": [], "additional_components": [ "Q9VPE2", "FBgn0037001", "species_113596", "Q9VXK7", "FBgn0030718", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VF27", "FBgn0017567", "FBgn0266582", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596" ] }, "reaction_10484318": { "compartment": "compartment_70616", "id": "reaction_10484318", "reactome": "R-DME-6799191", "name": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484277", "species_10436408", "species_10484282", "species_10484270" ], "products": [ "species_10484284" ], "modifiers": [], "additional_components": [ "FBgn0033891", "FBgn0013679", "FBgn0030352", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891" ] }, "reaction_10479981": { "compartment": "compartment_5460", "id": "reaction_10479981", "reactome": "R-DME-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477522", "species_10479977" ], "products": [ "species_10477520", "species_10479979" ], "modifiers": [], "additional_components": [ "Q9V9M8", "FBgn0032986", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q94511", "FBgn0017566", "Q9VXK7", "FBgn0030718", "FBgn0032986", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q94511", "FBgn0017566", "Q9VXK7", "FBgn0030718" ] }, "reaction_10484328": { "compartment": "compartment_5460", "id": "reaction_10484328", "reactome": "R-DME-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484256", "species_10484261", "species_10484266", "species_10484251" ], "products": [ "species_10484268" ], "modifiers": [], "additional_components": [ "FBgn0034919", "FBgn0037777", "FBgn0010340", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919" ] }, "reaction_10484326": { "compartment": "compartment_70616", "id": "reaction_10484326", "reactome": "R-DME-6799202", "name": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484305", "species_10484284" ], "products": [ "species_10484307" ], "modifiers": [], "additional_components": [ "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681" ] }, "reaction_10477524": { "compartment": "compartment_5460", "id": "reaction_10477524", "reactome": "R-DME-5690023", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477520", "species_169274" ], "products": [ "species_10477522" ], "modifiers": [], "additional_components": [ "FBgn0032986", "Q9V9M8", "FBgn0032986" ] }, "reaction_10484324": { "compartment": "compartment_70616", "id": "reaction_10484324", "reactome": "R-DME-6799197", "name": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436370", "species_10484307", "species_10436365" ], "products": [ "species_10484309" ], "modifiers": [], "additional_components": [ "FBgn0013684", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "FBgn0262952", "P18931", "FBgn0262952", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "P18932", "FBgn0013684" ] }, "reaction_10484322": { "compartment": "compartment_70616", "id": "reaction_10484322", "reactome": "R-DME-6799196", "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484320" ], "products": [ "species_10484256", "species_10484277", "species_10484261", "species_10436566", "species_10484247", "species_10484266", "species_10484282", "species_10484314", "species_10484303" ], "modifiers": [], "additional_components": [ "Q9VMU0", "FBgn0031684", "Q9VMI3", "FBgn0031771", "species_76629", "Q9VWI0", "FBgn0031021", "M9NEW0", "FBgn0263051", "Q94511", "FBgn0017566", "Q9VQD7", "FBgn0031436", "Q9VX36", "FBgn0030853", "P18931", "FBgn0262952", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "P18932", "FBgn0013684", "FBgn0034919", "FBgn0033891", "FBgn0037777", "Q9VMU0", "FBgn0031684", "Q9VMI3", "FBgn0031771", "species_76629", "Q9VWI0", "FBgn0031021", "Q94511", "FBgn0017566", "Q9VQD7", "FBgn0031436", "Q9VX36", "FBgn0030853", "P18931", "FBgn0262952", "P18932", "FBgn0013684", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "P18929", "FBgn0013679", "FBgn0037880", "FBgn0010340", "FBgn0030352", "FBgn0263051", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436" ] }, "reaction_10484272": { "compartment": "compartment_70616", "id": "reaction_10484272", "reactome": "R-DME-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436521", "species_10484268" ], "products": [ "species_10484270" ], "modifiers": [], "additional_components": [ "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "species_113596", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967" ] }, "reaction_10492180": { "compartment": "compartment_70101", "id": "reaction_10492180", "reactome": "R-DME-8936851", "name": "AHRR binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492174", "species_10458122" ], "products": [ "species_10492178" ], "modifiers": [], "additional_components": [ "FBgn0003513", "FBgn0264075", "O15945", "FBgn0264075", "E1JIM6", "FBgn0003513" ] }, "reaction_10492214": { "compartment": "compartment_70101", "id": "reaction_10492214", "reactome": "R-DME-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492170" ], "products": [ "species_10492212" ], "modifiers": [], "additional_components": [ "E1JIM6", "FBgn0003513", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_8936852", "Q9VH95", "FBgn0037728", "P02828", "FBgn0001233", "E1JIM6", "FBgn0003513", "species_8936852" ] }, "reaction_10492172": { "compartment": "compartment_70101", "id": "reaction_10492172", "reactome": "R-DME-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10492168" ], "products": [ "species_10492170" ], "modifiers": [], "additional_components": [ "E1JIM6", "FBgn0003513", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "E1JIM6", "FBgn0003513", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_8936852" ] }, "reaction_10492220": { "compartment": "compartment_7660", "id": "reaction_10492220", "reactome": "R-DME-8937177", "name": "AHR:TCDD binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492216", "species_10458122" ], "products": [ "species_10492218" ], "modifiers": [], "additional_components": [ "species_8936852", "E1JIM6", "FBgn0003513", "FBgn0264075", "O15945", "FBgn0264075", "species_8936852", "E1JIM6", "FBgn0003513" ] }, "reaction_10426932": { "compartment": "compartment_7660", "id": "reaction_10426932", "reactome": "R-DME-68637", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10426924" ], "modifiers": [ [ "species_10426928", "catalyst" ] ], "additional_components": [ "FBgn0035918" ] }, "reaction_10426946": { "compartment": "compartment_7660", "id": "reaction_10426946", "reactome": "R-DME-68688", "name": "CDC6 association with ORC:origin complexes mediated by MCM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426924", "species_10426942" ], "products": [ "species_10426944" ], "modifiers": [], "additional_components": [ "FBgn0035918", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918" ] }, "reaction_10436878": { "compartment": "compartment_5460", "id": "reaction_10436878", "reactome": "R-DME-164834", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436872", "species_163953" ], "products": [ "species_10436868", "species_113529", "species_113593" ], "modifiers": [ [ "species_10436872", "catalyst" ] ], "additional_components": [ "species_113592", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_113592", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081" ] }, "reaction_10436875": { "compartment": "compartment_5460", "id": "reaction_10436875", "reactome": "R-DME-164832", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436870" ], "products": [ "species_10436872", "species_113521" ], "modifiers": [ [ "species_10436870", "catalyst" ] ], "additional_components": [ "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_29370", "species_29372", "species_113592", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_29370", "species_29372" ] }, "reaction_10436880": { "compartment": "compartment_5460", "id": "reaction_10436880", "reactome": "R-DME-164840", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_10436868" ], "products": [ "species_10436870" ], "modifiers": [], "additional_components": [ "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_29370", "species_29372" ] }, "reaction_10442136": { "compartment": "compartment_70101", "id": "reaction_10442136", "reactome": "R-DME-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442132", "species_10441803" ], "products": [ "species_10442134" ], "modifiers": [], "additional_components": [ "FBgn0030915", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VWV8", "FBgn0030915" ] }, "reaction_10442216": { "compartment": "compartment_876", "id": "reaction_10442216", "reactome": "R-DME-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442134" ], "products": [ "species_10442214" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VWV8", "FBgn0030915", "Q9VWV8", "FBgn0030915", "species_71185", "species_1562550", "species_76629", "species_113596", "species_29870", "Q27571", "FBgn0011676" ] }, "reaction_10442198": { "compartment": "compartment_70101", "id": "reaction_10442198", "reactome": "R-DME-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10442196" ], "products": [ "species_10441862" ], "modifiers": [], "additional_components": [ "FBgn0011676", "FBgn0011676" ] }, "reaction_10442194": { "compartment": "compartment_20699", "id": "reaction_10442194", "reactome": "R-DME-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441862", "species_200993" ], "products": [ "species_10442144" ], "modifiers": [ [ "species_10442191", "catalyst" ] ], "additional_components": [ "FBgn0011676", "FBgn0011676", "Q9I7L7", "FBgn0042133", "Q9VBM6", "FBgn0039368", "Q9W251", "FBgn0034729", "Q8IQN9", "FBgn0036670", "Q9VBM5", "FBgn0039369", "Q9VBM8", "FBgn0039366", "Q0IGS7", "FBgn0033815", "Q9VBM4", "FBgn0039370", "Q9VBM7", "FBgn0039367" ] }, "reaction_10441870": { "compartment": "compartment_20699", "id": "reaction_10441870", "reactome": "R-DME-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441864" ], "products": [ "species_10441868" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870" ] }, "reaction_10442218": { "compartment": "compartment_20699", "id": "reaction_10442218", "reactome": "R-DME-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442144" ], "products": [ "species_10441803" ], "modifiers": [], "additional_components": [ "FBgn0011676", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596" ] }, "reaction_10459882": { "compartment": "compartment_70101", "id": "reaction_10459882", "reactome": "R-DME-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_1222424", "species_29366" ], "modifiers": [ [ "species_10459877", "catalyst" ] ], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "species_1497857", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10478081": { "compartment": "compartment_876", "id": "reaction_10478081", "reactome": "R-DME-5693373", "name": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5693375" ], "products": [ "species_5693410", "species_29968" ], "modifiers": [ [ "species_10478076", "catalyst" ] ], "additional_components": [ "FBgn0030467" ] }, "reaction_10442208": { "compartment": "compartment_876", "id": "reaction_10442208", "reactome": "R-DME-203613", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441803" ], "products": [ "species_76168", "species_10441864" ], "modifiers": [ [ "species_10442205", "catalyst" ] ], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "M9PEW1", "FBgn0042138" ] }, "reaction_10434767": { "compartment": "compartment_7660", "id": "reaction_10434767", "reactome": "R-DME-112379", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434753", "species_10434721", "species_10434758", "species_10431174", "species_10434681", "species_10434698", "species_10434763", "species_10434686" ], "products": [ "species_10434765" ], "modifiers": [], "additional_components": [ "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "FBgn0030738", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q7JRJ1", "FBgn0033166", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "FBgn0028982", "FBgn0010422", "P20232", "FBgn0010422", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q7JRJ1", "FBgn0033166", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "A8JV07", "FBgn0030738", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637" ] }, "reaction_10475420": { "compartment": "compartment_70101", "id": "reaction_10475420", "reactome": "R-DME-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661268", "species_29360" ], "products": [ "species_70106", "species_5661262", "species_73473" ], "modifiers": [ [ "species_10475417", "catalyst" ] ], "additional_components": [ "Q9VXI1", "FBgn0286508" ] }, "reaction_10475402": { "compartment": "compartment_70101", "id": "reaction_10475402", "reactome": "R-DME-5661240", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5660036" ], "products": [ "species_5660033", "species_29366" ], "modifiers": [ [ "species_10475399", "catalyst" ] ], "additional_components": [ "Q9VWP2", "FBgn0030968" ] }, "reaction_10475431": { "compartment": "compartment_70101", "id": "reaction_10475431", "reactome": "R-DME-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_5661281", "species_73473" ], "modifiers": [ [ "species_10474621", "catalyst" ] ], "additional_components": [ "species_1562550", "O96299", "FBgn0022359" ] }, "reaction_10475428": { "compartment": "compartment_70101", "id": "reaction_10475428", "reactome": "R-DME-5662466", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5661281" ], "products": [ "species_29790", "species_29370" ], "modifiers": [ [ "species_10475425", "catalyst" ] ], "additional_components": [ "FBgn0038463" ] }, "reaction_10475410": { "compartment": "compartment_70101", "id": "reaction_10475410", "reactome": "R-DME-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10475407", "catalyst" ] ], "additional_components": [ "FBgn0035476" ] }, "reaction_10454299": { "compartment": "compartment_5460", "id": "reaction_10454299", "reactome": "R-DME-880033", "name": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_880041" ], "products": [ "species_880046", "species_879997" ], "modifiers": [ [ "species_10454286", "catalyst" ] ], "additional_components": [ "FBgn0017482" ] }, "reaction_10454297": { "compartment": "compartment_5460", "id": "reaction_10454297", "reactome": "R-DME-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10454294", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_880067", "catalyst" ], [ "species_113527", "catalyst" ] ], "additional_components": [ "FBgn0023507" ] }, "reaction_10454307": { "compartment": "compartment_70616", "id": "reaction_10454307", "reactome": "R-DME-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10454304", "catalyst" ] ], "additional_components": [ "FBgn0032729" ] }, "reaction_10479469": { "compartment": "compartment_70101", "id": "reaction_10479469", "reactome": "R-DME-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10479466", "catalyst" ] ], "additional_components": [ "species_1562550", "Q8IPU3", "FBgn0037024" ] }, "reaction_10496099": { "compartment": "compartment_5460", "id": "reaction_10496099", "reactome": "R-DME-9011543", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442340", "species_9010792" ], "products": [ "species_10442347" ], "modifiers": [], "additional_components": [ "FBgn0017558", "P91622", "FBgn0017558" ] }, "reaction_10442392": { "compartment": "compartment_5460", "id": "reaction_10442392", "reactome": "R-DME-204169", "name": "PDP dephosphorylates p-lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442333", "species_113521" ], "products": [ "species_10428865", "species_113548" ], "modifiers": [ [ "species_10442389", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q9VM14", "FBgn0283658", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "species_113596", "Q9VVL7", "FBgn0036762", "Q9VM14", "FBgn0283658", "species_113596", "Q9VVL7", "FBgn0036762", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "Q9W4K8", "FBgn0029706", "species_113596", "Q9W3Q1", "FBgn0029958" ] }, "reaction_10496106": { "compartment": "compartment_5460", "id": "reaction_10496106", "reactome": "R-DME-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_904849", "species_3301973" ], "modifiers": [ [ "species_10496103", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "Q9VHD2", "FBgn0037697", "species_29450" ] }, "reaction_10496180": { "compartment": "compartment_70101", "id": "reaction_10496180", "reactome": "R-DME-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_113528", "species_29398", "species_29364" ], "modifiers": [ [ "species_10496177", "catalyst" ] ], "additional_components": [ "species_29926", "Q86NT5", "FBgn0029154", "A1ZAF6", "FBgn0029153", "Q9VG31", "FBgn0002719", "E1JIZ4", "FBgn0029155", "Q7K3R0", "FBgn0034127" ] }, "reaction_10486326": { "compartment": "compartment_5460", "id": "reaction_10486326", "reactome": "R-DME-6807826", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113557", "species_29362" ], "products": [ "species_113526", "species_6807616" ], "modifiers": [ [ "species_10486323", "catalyst" ] ], "additional_components": [ "Q95028", "FBgn0001258", "A1Z9F8", "FBgn0033856" ] }, "reaction_10428151": { "compartment": "compartment_70101", "id": "reaction_10428151", "reactome": "R-DME-70510", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_29360" ], "products": [ "species_70106", "species_29398", "species_73473" ], "modifiers": [ [ "species_10428148", "catalyst" ] ], "additional_components": [ "A1Z9F8", "FBgn0033856", "Q95028", "FBgn0001258" ] }, "reaction_10496232": { "compartment": "compartment_70101", "id": "reaction_10496232", "reactome": "R-DME-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10470842", "catalyst" ] ], "additional_components": [ "Q9VKP4", "FBgn0260453", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q94920", "FBgn0004363" ] }, "reaction_10428868": { "compartment": "compartment_5460", "id": "reaction_10428868", "reactome": "R-DME-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_113557" ], "products": [ "species_113559", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428865", "catalyst" ] ], "additional_components": [ "Q9VM14", "FBgn0283658", "species_113596", "Q9VVL7", "FBgn0036762", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325" ] }, "reaction_10429155": { "compartment": "compartment_70101", "id": "reaction_10429155", "reactome": "R-DME-71849", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29398", "species_73473" ], "products": [ "species_29708", "species_29360" ], "modifiers": [ [ "species_10428148", "catalyst" ] ], "additional_components": [ "A1Z9F8", "FBgn0033856", "Q95028", "FBgn0001258" ] }, "reaction_10478225": { "compartment": "compartment_70101", "id": "reaction_10478225", "reactome": "R-DME-5694071", "name": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694074", "species_29450" ], "products": [ "species_5694130" ], "modifiers": [ [ "species_10478222", "catalyst" ] ], "additional_components": [ "species_1562550", "A1Z6X6", "FBgn0283450" ] }, "reaction_10496229": { "compartment": "compartment_5460", "id": "reaction_10496229", "reactome": "R-DME-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113529", "species_113557", "species_113600", "species_29376" ], "modifiers": [ [ "species_10496226", "catalyst" ] ], "additional_components": [ "species_29926", "E1JIZ4", "FBgn0029155" ] }, "reaction_10428534": { "compartment": "compartment_5460", "id": "reaction_10428534", "reactome": "R-DME-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10428531", "catalyst" ] ], "additional_components": [ "Q9W401", "FBgn0261955" ] }, "reaction_10428598": { "compartment": "compartment_5460", "id": "reaction_10428598", "reactome": "R-DME-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113581" ], "products": [ "species_29374", "species_113593", "species_113536" ], "modifiers": [ [ "species_10428595", "catalyst" ] ], "additional_components": [ "Q94522", "FBgn0004888", "Q95U38", "FBgn0037643" ] }, "reaction_10496201": { "compartment": "compartment_5460", "id": "reaction_10496201", "reactome": "R-DME-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_113557", "species_29362", "species_29376" ], "modifiers": [ [ "species_10496198", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "A1ZAF6", "FBgn0029153", "E1JIZ4", "FBgn0029155", "Q7K3R0", "FBgn0034127", "Q86NT5", "FBgn0029154", "Q9VG31", "FBgn0002719", "species_29926" ] }, "reaction_10496144": { "compartment": "compartment_5460", "id": "reaction_10496144", "reactome": "R-DME-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10496141", "catalyst" ] ], "additional_components": [ "Q9VDE2", "FBgn0038858", "species_29926" ] }, "reaction_10428524": { "compartment": "compartment_5460", "id": "reaction_10428524", "reactome": "R-DME-70971", "name": "citrate <=> isocitrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654" ], "products": [ "species_29938" ], "modifiers": [ [ "species_10428521", "catalyst" ] ], "additional_components": [ "FBgn0010100" ] }, "reaction_10451212": { "compartment": "compartment_5460", "id": "reaction_10451212", "reactome": "R-DME-451033", "name": "(S)-Malate <=> Fumarate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544" ], "products": [ "species_113588", "species_113521" ], "modifiers": [ [ "species_10428551", "catalyst" ] ], "additional_components": [ "Q9W3X6", "FBgn0286222" ] }, "reaction_10428583": { "compartment": "compartment_5460", "id": "reaction_10428583", "reactome": "R-DME-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10428580", "catalyst" ] ], "additional_components": [ "Q9VGS3", "FBgn0037873", "P21914", "FBgn0014028", "Q9VCI5", "FBgn0039112", "Q94523", "FBgn0261439", "species_113596" ] }, "reaction_10428870": { "compartment": "compartment_5460", "id": "reaction_10428870", "reactome": "R-DME-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_70958", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428624", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "species_8878387", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10428516": { "compartment": "compartment_5460", "id": "reaction_10428516", "reactome": "R-DME-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_29938" ], "products": [ "species_113594", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428513", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q8MT18", "FBgn0039358", "Q9VD58", "FBgn0038922", "species_266099", "Q9VWH4", "FBgn0027291" ] }, "reaction_10429124": { "compartment": "compartment_5460", "id": "reaction_10429124", "reactome": "R-DME-71783", "name": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_29362", "species_113587" ], "products": [ "species_113544", "species_113526" ], "modifiers": [ [ "species_10428541", "catalyst" ] ], "additional_components": [ "Q9VEB1", "FBgn0262559" ] }, "reaction_10429122": { "compartment": "compartment_5460", "id": "reaction_10429122", "reactome": "R-DME-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113525" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10429119", "catalyst" ] ], "additional_components": [ "Q9V470", "FBgn0029118", "Q94522", "FBgn0004888" ] }, "reaction_10487120": { "compartment": "compartment_20699", "id": "reaction_10487120", "reactome": "R-DME-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487116", "species_10486635" ], "products": [ "species_10487118" ], "modifiers": [], "additional_components": [ "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q7JY00", "FBgn0037084", "Q9W0N6", "FBgn0260862", "Q9W1I8", "FBgn0034913", "Q9VHB5", "FBgn0261049", "Q9VR90", "FBgn0031106", "Q9VE50", "FBgn0044871", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q7JY00", "FBgn0037084", "Q9W0N6", "FBgn0260862", "Q9W1I8", "FBgn0034913", "Q9VHB5", "FBgn0261049", "Q9VR90", "FBgn0031106", "Q9VE50", "FBgn0044871" ] }, "reaction_10487796": { "compartment": "compartment_20699", "id": "reaction_10487796", "reactome": "R-DME-8847875", "name": "ARF1:GTP binds Golgin TRIP11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461046", "species_10487792" ], "products": [ "species_10487794" ], "modifiers": [], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "A0A4D6K5M0", "FBgn0027287", "A0A4D6K5M0", "FBgn0027287", "P61209", "FBgn0010348", "species_29438" ] }, "reaction_10488246": { "compartment": "compartment_20699", "id": "reaction_10488246", "reactome": "R-DME-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486635", "species_10488242" ], "products": [ "species_10488244" ], "modifiers": [], "additional_components": [ "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "species_29438", "O18334", "Rab6", "Q9W0A7", "FBgn0035255", "Q9W3Q0", "FBgn0029959", "Q9VM50", "FBgn0031882", "species_29438", "O18334", "Rab6", "Q9W0A7", "FBgn0035255", "Q9W3Q0", "FBgn0029959", "Q9VM50", "FBgn0031882", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401" ] }, "reaction_10487719": { "compartment": "compartment_20699", "id": "reaction_10487719", "reactome": "R-DME-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10478727", "species_10487715" ], "products": [ "species_10487717" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9W3M8", "FBgn0260858", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9W3M8", "FBgn0260858", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487815": { "compartment": "compartment_20699", "id": "reaction_10487815", "reactome": "R-DME-8847880", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461046", "species_10487801" ], "products": [ "species_10487813" ], "modifiers": [], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "FBgn0086779", "P61209", "FBgn0010348", "species_29438", "Q0E8N2", "FBgn0086779" ] }, "reaction_10487822": { "compartment": "compartment_20699", "id": "reaction_10487822", "reactome": "R-DME-8847883", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487813" ], "products": [ "species_10487819" ], "modifiers": [ [ "species_10487813", "catalyst" ] ], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "Q0E8N2", "FBgn0086779", "P61209", "FBgn0010348", "species_29420", "Q0E8N2", "FBgn0086779", "P61209", "FBgn0010348", "species_29438", "Q0E8N2", "FBgn0086779" ] }, "reaction_10474701": { "compartment": "compartment_17963", "id": "reaction_10474701", "reactome": "R-DME-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10474698", "catalyst" ] ], "additional_components": [ "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047" ] }, "reaction_10474773": { "compartment": "compartment_17963", "id": "reaction_10474773", "reactome": "R-DME-5653878", "name": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_964746" ], "products": [ "species_5653871", "species_205687" ], "modifiers": [ [ "species_10474770", "catalyst" ] ], "additional_components": [ "Q7KN92", "FBgn0027538", "P83972", "FBgn0004427", "A1ZBX6", "FBgn0034538", "P83971", "FBgn0004426", "A1ZAB8", "FBgn0034092", "P37161", "FBgn0004431", "A1Z9D5", "FBgn0050062", "P37160", "FBgn0004430", "Q9W4C2", "FBgn0029765", "P37159", "FBgn0004428", "Q9VSA5", "FBgn0035813", "P29615", "FBgn0004429", "Q08694", "FBgn0004425", "A1ZBX7", "FBgn0034539" ] }, "reaction_10474803": { "compartment": "compartment_17963", "id": "reaction_10474803", "reactome": "R-DME-5653886", "name": "B4GALT1 binds LALBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474801", "species_10455850" ], "products": [ "species_10474770" ], "modifiers": [ [ "species_735682", "catalyst" ], [ "species_5653875", "catalyst" ] ], "additional_components": [ "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "FBgn0027538", "Q7KN92", "FBgn0027538", "P83972", "FBgn0004427", "A1ZBX6", "FBgn0034538", "P83971", "FBgn0004426", "A1ZAB8", "FBgn0034092", "P37161", "FBgn0004431", "A1Z9D5", "FBgn0050062", "P37160", "FBgn0004430", "Q9W4C2", "FBgn0029765", "P37159", "FBgn0004428", "Q9VSA5", "FBgn0035813", "P29615", "FBgn0004429", "Q08694", "FBgn0004425", "A1ZBX7", "FBgn0034539" ] }, "reaction_10431982": { "compartment": "compartment_7660", "id": "reaction_10431982", "reactome": "R-DME-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10431972" ], "products": [ "species_113582", "species_10431980" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0261278" ] }, "reaction_10427788": { "compartment": "compartment_7660", "id": "reaction_10427788", "reactome": "R-DME-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427741" ], "products": [ "species_113582", "species_10427778" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "FBgn0261278" ] }, "reaction_10438571": { "compartment": "compartment_7660", "id": "reaction_10438571", "reactome": "R-DME-176250", "name": "Binding of ATR-ATRIP to the RPA-ssDNA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438544", "species_10438562" ], "products": [ "species_10438569" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438567": { "compartment": "compartment_7660", "id": "reaction_10438567", "reactome": "R-DME-176175", "name": "Stalling of DNA replication fork and RPA binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_176104" ], "products": [ "species_10438544" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438548": { "compartment": "compartment_7660", "id": "reaction_10438548", "reactome": "R-DME-176101", "name": "Recruitment of Rad17-RFC complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438544", "species_10438542" ], "products": [ "species_10438546" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438612": { "compartment": "compartment_7660", "id": "reaction_10438612", "reactome": "R-DME-176318", "name": "Loading of claspin onto DNA during replication origin firing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427361", "species_10438600" ], "products": [ "species_10438602" ], "modifiers": [], "additional_components": [ "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "FBgn0052251", "Q8IRB5", "FBgn0052251", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10438595": { "compartment": "compartment_7660", "id": "reaction_10438595", "reactome": "R-DME-176264", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438546", "species_10438590" ], "products": [ "species_10438592" ], "modifiers": [ [ "species_10438546", "catalyst" ] ], "additional_components": [ "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VQD4", "FBgn0026778", "Q9VN60", "FBgn0026417", "A8JNV5", "FBgn0025807", "Q9VQD4", "FBgn0026778", "Q9VN60", "FBgn0026417", "A8JNV5", "FBgn0025807", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438610": { "compartment": "compartment_7660", "id": "reaction_10438610", "reactome": "R-DME-176298", "name": "Activation of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438602" ], "products": [ "species_10438608", "species_113582" ], "modifiers": [ [ "species_10438562", "catalyst" ] ], "additional_components": [ "Q8IRB5", "FBgn0052251", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "Q8IRB5", "FBgn0052251", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367" ] }, "reaction_209322": { "compartment": "compartment_7660", "id": "reaction_209322", "reactome": "R-DME-209322", "name": "In the absence of ARM, GRO binds to PAN and inhibits transcription", "reversible": "false", "notes": "In the absence of Armadillo (ARM) due to an active 'destruction complex' removing it in the cytoplasm, the protein Groucho (GRO) binds to Pangolin (PAN) and inhibits transcription.", "reactants": [ "species_205750", "species_205730" ], "products": [ "species_206798" ], "modifiers": [], "additional_components": [ "P91943", "PAN", "P16371", "GRO" ] }, "reaction_10464863": { "compartment": "compartment_161320", "id": "reaction_10464863", "reactome": "R-DME-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10460515", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10462796": { "compartment": "compartment_984", "id": "reaction_10462796", "reactome": "R-DME-2022056", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462724", "species_10462750" ], "products": [ "species_10462776", "species_10462794" ], "modifiers": [], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872" ] }, "reaction_10461387": { "compartment": "compartment_161320", "id": "reaction_10461387", "reactome": "R-DME-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105025" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10461298", "catalyst" ] ], "additional_components": [ "FBgn0032343" ] }, "reaction_10497909": { "compartment": "compartment_161320", "id": "reaction_10497909", "reactome": "R-DME-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10460517", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10461385": { "compartment": "compartment_161320", "id": "reaction_10461385", "reactome": "R-DME-1793182", "name": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065213" ], "products": [ "species_2065269", "species_1606845" ], "modifiers": [ [ "species_10461225", "catalyst" ] ], "additional_components": [ "Q9VZP8", "FBgn0035445", "species_74016" ] }, "reaction_10458176": { "compartment": "compartment_70101", "id": "reaction_10458176", "reactome": "R-DME-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_8942986", "species_983036" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10497911": { "compartment": "compartment_161320", "id": "reaction_10497911", "reactome": "R-DME-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10460517", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10465157": { "compartment": "compartment_161320", "id": "reaction_10465157", "reactome": "R-DME-2162227", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160866" ], "products": [ "species_2162223", "species_1678868" ], "modifiers": [ [ "species_10461348", "catalyst" ] ], "additional_components": [ "species_2162224", "A1ZBG9", "FBgn0034417" ] }, "reaction_10465155": { "compartment": "compartment_161320", "id": "reaction_10465155", "reactome": "R-DME-2162226", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2162224" ], "products": [ "species_1678743", "species_1678868" ], "modifiers": [ [ "species_10461348", "catalyst" ] ], "additional_components": [ "A1ZBG9", "FBgn0034417" ] }, "reaction_10465153": { "compartment": "compartment_161320", "id": "reaction_10465153", "reactome": "R-DME-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10460515", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10438422": { "compartment": "compartment_70101", "id": "reaction_10438422", "reactome": "R-DME-174392", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174375" ], "products": [ "species_111294", "species_174370" ], "modifiers": [ [ "species_10438414", "catalyst" ] ], "additional_components": [ "FBgn0020389" ] }, "reaction_10438419": { "compartment": "compartment_70101", "id": "reaction_10438419", "reactome": "R-DME-174389", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174370" ], "products": [ "species_29370", "species_158471" ], "modifiers": [ [ "species_10438414", "catalyst" ] ], "additional_components": [ "FBgn0020389" ] }, "reaction_10461983": { "compartment": "compartment_20699", "id": "reaction_10461983", "reactome": "R-DME-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10461911" ], "products": [ "species_10461945", "species_205687" ], "modifiers": [ [ "species_10461980", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "O97422", "FBgn0066114", "Q9VTG7", "FBgn0036144", "Q9VLA1", "FBgn0032135", "species_266099" ] }, "reaction_10497906": { "compartment": "compartment_20699", "id": "reaction_10497906", "reactome": "R-DME-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10461911" ], "products": [ "species_10461945", "species_205687" ], "modifiers": [ [ "species_10461978", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "O97422", "FBgn0066114", "species_266099" ] }, "reaction_10462025": { "compartment": "compartment_20699", "id": "reaction_10462025", "reactome": "R-DME-1889978", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462017", "species_735682" ], "products": [ "species_10461911", "species_205687" ], "modifiers": [ [ "species_10462022", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "FBgn0033315" ] }, "reaction_10461877": { "compartment": "compartment_20699", "id": "reaction_10461877", "reactome": "R-DME-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461833", "species_742361" ], "products": [ "species_10461867", "species_205687" ], "modifiers": [ [ "species_10461872", "catalyst" ] ], "additional_components": [ "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "FBgn0015360" ] }, "reaction_10462033": { "compartment": "compartment_20699", "id": "reaction_10462033", "reactome": "R-DME-1889981", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10461867" ], "products": [ "species_10462017", "species_205687" ], "modifiers": [ [ "species_10462030", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "FBgn0039258" ] }, "reaction_10462812": { "compartment": "compartment_20699", "id": "reaction_10462812", "reactome": "R-DME-2022061", "name": "Dermatan sulfate can be further sulfated on position 2 of iduronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10462684" ], "products": [ "species_742343", "species_10462804" ], "modifiers": [ [ "species_10462809", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "FBgn0003089" ] }, "reaction_10462828": { "compartment": "compartment_17963", "id": "reaction_10462828", "reactome": "R-DME-2022065", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462826" ], "products": [ "species_10462724" ], "modifiers": [], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872" ] }, "reaction_10462415": { "compartment": "compartment_20699", "id": "reaction_10462415", "reactome": "R-DME-1971483", "name": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10462365" ], "products": [ "species_742343", "species_10462375" ], "modifiers": [ [ "species_10462412", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VMS3", "FBgn0031697", "Q9VJG5", "FBgn0032618", "Q8IRG5", "FBgn0035287" ] }, "reaction_10463695": { "compartment": "compartment_17963", "id": "reaction_10463695", "reactome": "R-DME-2022911", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463693" ], "products": [ "species_10462750" ], "modifiers": [], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872" ] }, "reaction_10462445": { "compartment": "compartment_20699", "id": "reaction_10462445", "reactome": "R-DME-1971491", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10462345" ], "products": [ "species_10462425", "species_205687" ], "modifiers": [ [ "species_10462437", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VYH2", "FBgn0263005", "Q7KUZ9", "FBgn0030662" ] }, "reaction_10462440": { "compartment": "compartment_20699", "id": "reaction_10462440", "reactome": "R-DME-1971487", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10462425" ], "products": [ "species_205687", "species_10462365" ], "modifiers": [ [ "species_10462437", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VYH2", "FBgn0263005", "Q7KUZ9", "FBgn0030662" ] }, "reaction_10462355": { "compartment": "compartment_20699", "id": "reaction_10462355", "reactome": "R-DME-1971482", "name": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10462335" ], "products": [ "species_10462345", "species_205687" ], "modifiers": [ [ "species_10462350", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "FBgn0033500" ] }, "reaction_10497804": { "compartment": "compartment_20699", "id": "reaction_10497804", "reactome": "R-DME-9632033", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10462425" ], "products": [ "species_205687", "species_10462365" ], "modifiers": [ [ "species_10497801", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "FBgn0030662" ] }, "reaction_10497807": { "compartment": "compartment_20699", "id": "reaction_10497807", "reactome": "R-DME-9632034", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10462345" ], "products": [ "species_10462425", "species_205687" ], "modifiers": [ [ "species_10497801", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "FBgn0030662" ] }, "reaction_10462672": { "compartment": "compartment_20699", "id": "reaction_10462672", "reactome": "R-DME-2018682", "name": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10462365" ], "products": [ "species_742343", "species_10462649" ], "modifiers": [ [ "species_10462669", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VMC4", "FBgn0031826", "Q9VMC3", "FBgn0051637" ] }, "reaction_10461519": { "compartment": "compartment_70101", "id": "reaction_10461519", "reactome": "R-DME-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_870330" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10461516", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUW3", "FBgn0036553", "Q7KTW5", "FBgn0037063", "Q9VUW2", "FBgn0036553", "Q9VUW1", "FBgn0036550", "Q9VUW4", "FBgn0036553", "Q9VP62", "FBgn0037064" ] }, "reaction_10461647": { "compartment": "compartment_70101", "id": "reaction_10461647", "reactome": "R-DME-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629746" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10461723": { "compartment": "compartment_876", "id": "reaction_10461723", "reactome": "R-DME-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10461720", "catalyst" ] ], "additional_components": [ "O46094", "FBgn0023508", "B7Z0Q2", "FBgn0259178" ] }, "reaction_10461611": { "compartment": "compartment_70101", "id": "reaction_10461611", "reactome": "R-DME-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10461674": { "compartment": "compartment_70101", "id": "reaction_10461674", "reactome": "R-DME-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629753" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10461516", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUW3", "FBgn0036553", "Q7KTW5", "FBgn0037063", "Q9VUW2", "FBgn0036553", "Q9VUW1", "FBgn0036550", "Q9VUW4", "FBgn0036553", "Q9VP62", "FBgn0037064" ] }, "reaction_10476185": { "compartment": "compartment_70101", "id": "reaction_10476185", "reactome": "R-DME-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_426910" ], "products": [ "species_29356", "species_70106", "species_2162232" ], "modifiers": [ [ "species_10476182", "catalyst" ] ], "additional_components": [ "species_111793", "Q9VTU9", "FBgn0036262" ] }, "reaction_10461671": { "compartment": "compartment_70101", "id": "reaction_10461671", "reactome": "R-DME-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10461516", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUW3", "FBgn0036553", "Q7KTW5", "FBgn0037063", "Q9VUW2", "FBgn0036553", "Q9VUW1", "FBgn0036550", "Q9VUW4", "FBgn0036553", "Q9VP62", "FBgn0037064" ] }, "reaction_10461572": { "compartment": "compartment_70101", "id": "reaction_10461572", "reactome": "R-DME-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10461569", "catalyst" ] ], "additional_components": [ "M9PHS8", "FBgn0030761", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10461668": { "compartment": "compartment_70101", "id": "reaction_10461668", "reactome": "R-DME-1855208", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629739" ], "products": [ "species_29372", "species_1629753" ], "modifiers": [ [ "species_10461665", "catalyst" ] ], "additional_components": [ "Q9VFP6", "FBgn0016672", "species_29926" ] }, "reaction_10461603": { "compartment": "compartment_70101", "id": "reaction_10461603", "reactome": "R-DME-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10461600", "catalyst" ] ], "additional_components": [ "species_427523", "O97477", "FBgn0025885" ] }, "reaction_10461744": { "compartment": "compartment_70101", "id": "reaction_10461744", "reactome": "R-DME-1855232", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629746" ], "modifiers": [ [ "species_10461665", "catalyst" ] ], "additional_components": [ "Q9VFP6", "FBgn0016672", "species_29926" ] }, "reaction_10435903": { "compartment": "compartment_13959", "id": "reaction_10435903", "reactome": "R-DME-159783", "name": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435829" ], "products": [ "species_10435901" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10435817": { "compartment": "compartment_13959", "id": "reaction_10435817", "reactome": "R-DME-159757", "name": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435815" ], "products": [ "species_10435779" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10436713": { "compartment": "compartment_13959", "id": "reaction_10436713", "reactome": "R-DME-163825", "name": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436709" ], "products": [ "species_10436663" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459" ] }, "reaction_10436697": { "compartment": "compartment_13959", "id": "reaction_10436697", "reactome": "R-DME-163809", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436693" ], "products": [ "species_10436695" ], "modifiers": [], "additional_components": [ "FBgn0027594", "FBgn0027594" ] }, "reaction_10435879": { "compartment": "compartment_13959", "id": "reaction_10435879", "reactome": "R-DME-159762", "name": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435863" ], "products": [ "species_10435877" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10435972": { "compartment": "compartment_13959", "id": "reaction_10435972", "reactome": "R-DME-159836", "name": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435958" ], "products": [ "species_10435932" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10473803": { "compartment": "compartment_876", "id": "reaction_10473803", "reactome": "R-DME-5624126", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473254", "species_10473799", "species_10473785" ], "products": [ "species_10473801" ], "modifiers": [], "additional_components": [ "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "A1ZBK9", "FBgn0034446", "species_29438", "A1ZBK9", "FBgn0034446", "species_29438", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280" ] }, "reaction_10473835": { "compartment": "compartment_261122", "id": "reaction_10473835", "reactome": "R-DME-5624127", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473801" ], "products": [ "species_10473833" ], "modifiers": [], "additional_components": [ "A1ZBK9", "FBgn0034446", "species_29438", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280", "species_29438", "A1ZBK9", "FBgn0034446", "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260" ] }, "reaction_10488803": { "compartment": "compartment_984", "id": "reaction_10488803", "reactome": "R-DME-8852809", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488798" ], "products": [ "species_10488800" ], "modifiers": [ [ "species_10464252", "catalyst" ] ], "additional_components": [ "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VCM8", "FBgn0039073", "Q961J8", "FBgn0035781", "Q7JYV3", "FBgn0033774", "Q9W478", "FBgn0029804", "Q0E9F9", "FBgn0033241", "Q9W477", "FBgn0259149", "M9PEV1", "FBgn0035776", "Q9W475", "FBgn0029807", "Q9VX86", "FBgn0030815", "Q9VS80", "FBgn0035791", "Q9VS67", "FBgn0035780", "Q9VS66", "FBgn0035779", "Q9VS65", "FBgn0052379", "Q9VS64", "FBgn0035777", "Q9VRZ3", "FBgn0035718", "Q9VLZ2", "FBgn0031929", "Q9VLZ1", "FBgn0031930", "Q9VL87", "FBgn0032143", "Q9VL86", "FBgn0032144" ] }, "reaction_10455979": { "compartment": "compartment_984", "id": "reaction_10455979", "reactome": "R-DME-976801", "name": "Complement factor I complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455955", "species_10455975" ], "products": [ "species_10455977" ], "modifiers": [], "additional_components": [ "A1Z7M3", "FBgn0265011", "A8DY75", "FBgn0033362", "Q9VRS5", "FBgn0035663", "A1Z709", "FBgn0033192", "A1Z7M7", "FBgn0033365", "Q05319", "FBgn0003319", "A1Z7M5", "FBgn0033363", "B7YZU2", "FBgn0286782", "Q9VZH5", "FBgn0035501", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319" ] }, "reaction_10457578": { "compartment": "compartment_876", "id": "reaction_10457578", "reactome": "R-DME-1006143", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456081", "species_10456083" ], "products": [ "species_10456085" ], "modifiers": [], "additional_components": [ "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10467082": { "compartment": "compartment_984", "id": "reaction_10467082", "reactome": "R-DME-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10437245" ], "products": [ "species_10456099" ], "modifiers": [], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10493671": { "compartment": "compartment_876", "id": "reaction_10493671", "reactome": "R-DME-8951486", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456081", "species_10456122" ], "products": [ "species_10456124" ], "modifiers": [], "additional_components": [ "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10456231": { "compartment": "compartment_876", "id": "reaction_10456231", "reactome": "R-DME-977615", "name": "Factor I inactivates MCP/CR1-bound C4b/C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456132" ], "products": [ "species_10456228", "species_10455977", "species_10456186", "species_10456188" ], "modifiers": [ [ "species_10456132", "catalyst" ] ], "additional_components": [ "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10456134": { "compartment": "compartment_876", "id": "reaction_10456134", "reactome": "R-DME-977602", "name": "Complement factor I binds to MCP, CR1:C4b, C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456130", "species_10455977" ], "products": [ "species_10456132" ], "modifiers": [], "additional_components": [ "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10468164": { "compartment": "compartment_876", "id": "reaction_10468164", "reactome": "R-DME-3266557", "name": "Factor I cleaves iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468123" ], "products": [ "species_10468161", "species_10468149", "species_10456075" ], "modifiers": [ [ "species_10455977", "catalyst" ] ], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319" ] }, "reaction_10488811": { "compartment": "compartment_876", "id": "reaction_10488811", "reactome": "R-DME-8852874", "name": "CR2 binds C3d, C3dg, iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488807", "species_10488805" ], "products": [ "species_10488809" ], "modifiers": [], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "FBgn0001083", "Q9VYR4", "FBgn0001083", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180" ] }, "reaction_10459709": { "compartment": "compartment_12045", "id": "reaction_10459709", "reactome": "R-DME-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10459706", "catalyst" ] ], "additional_components": [ "Q960U8", "FBgn0004797", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216", "Q7K1C2", "FBgn0033215" ] }, "reaction_10479149": { "compartment": "compartment_12045", "id": "reaction_10479149", "reactome": "R-DME-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10459644": { "compartment": "compartment_12045", "id": "reaction_10459644", "reactome": "R-DME-1482654", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728" ], "products": [ "species_76116", "species_1500596" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10459642": { "compartment": "compartment_12045", "id": "reaction_10459642", "reactome": "R-DME-1482647", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_1500596" ], "products": [ "species_76116", "species_1500594" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10459672": { "compartment": "compartment_12045", "id": "reaction_10459672", "reactome": "R-DME-1482777", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500594" ], "products": [ "species_1524021", "species_1500596" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10459686": { "compartment": "compartment_12045", "id": "reaction_10459686", "reactome": "R-DME-1482811", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500596" ], "products": [ "species_1498728", "species_1524021" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10487933": { "compartment": "compartment_12045", "id": "reaction_10487933", "reactome": "R-DME-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10487930", "catalyst" ] ], "additional_components": [ "A1Z739", "FBgn0033216", "Q7JYK2", "FBgn0033214", "Q7K1C2", "FBgn0033215" ] }, "reaction_10459690": { "compartment": "compartment_70616", "id": "reaction_10459690", "reactome": "R-DME-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524083", "species_1498773" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10459677", "catalyst" ] ], "additional_components": [ "FBgn0026619" ] }, "reaction_10459683": { "compartment": "compartment_70616", "id": "reaction_10459683", "reactome": "R-DME-1482794", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524079" ], "products": [ "species_1524075", "species_1498773" ], "modifiers": [ [ "species_10459677", "catalyst" ] ], "additional_components": [ "FBgn0026619" ] }, "reaction_10459667": { "compartment": "compartment_70616", "id": "reaction_10459667", "reactome": "R-DME-1482775", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524038" ], "products": [ "species_1524072", "species_29374" ], "modifiers": [ [ "species_10459664", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10479135": { "compartment": "compartment_5460", "id": "reaction_10479135", "reactome": "R-DME-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696414", "species_113521" ], "products": [ "species_113548", "species_113532", "species_5693978" ], "modifiers": [ [ "species_10479132", "catalyst" ] ], "additional_components": [ "Q9VU95", "FBgn0036381" ] }, "reaction_10459804": { "compartment": "compartment_70101", "id": "reaction_10459804", "reactome": "R-DME-1483096", "name": "PETA is dephosphorylated to ETA by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428686" ], "products": [ "species_29372", "species_1498751" ], "modifiers": [ [ "species_10459801", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VWF3", "FBgn0031045", "Q9VWF0", "FBgn0031048" ] }, "reaction_10459850": { "compartment": "compartment_12045", "id": "reaction_10459850", "reactome": "R-DME-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428686", "species_110614" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10459847", "catalyst" ] ], "additional_components": [ "Q9VK25", "FBgn0032482" ] }, "reaction_10459861": { "compartment": "compartment_12045", "id": "reaction_10459861", "reactome": "R-DME-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10459858", "catalyst" ] ], "additional_components": [ "species_29926", "Q8SXP0", "FBgn0263593" ] }, "reaction_10459733": { "compartment": "compartment_12045", "id": "reaction_10459733", "reactome": "R-DME-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10459730", "catalyst" ] ], "additional_components": [ "species_29926", "species_266099", "Q9VIU4", "FBgn0053116", "Q8T0S3", "FBgn0031948" ] }, "reaction_10459873": { "compartment": "compartment_70101", "id": "reaction_10459873", "reactome": "R-DME-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10459870", "catalyst" ] ], "additional_components": [ "Q8IMF4", "FBgn0032955", "P54352", "FBgn0000536" ] }, "reaction_10459743": { "compartment": "compartment_12045", "id": "reaction_10459743", "reactome": "R-DME-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_426639", "species_109395" ], "modifiers": [ [ "species_10459740", "catalyst" ] ], "additional_components": [ "Q8SX37", "FBgn0030670", "species_29926", "species_266099" ] }, "reaction_10459814": { "compartment": "compartment_12045", "id": "reaction_10459814", "reactome": "R-DME-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_111294", "species_426955" ], "modifiers": [ [ "species_10459811", "catalyst" ] ], "additional_components": [ "species_29926", "P56079", "FBgn0010350" ] }, "reaction_10490382": { "compartment": "compartment_70101", "id": "reaction_10490382", "reactome": "R-DME-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10490379", "catalyst" ] ], "additional_components": [ "P43125", "FBgn0003218", "Q9VLS7", "FBgn0031990" ] }, "reaction_10459764": { "compartment": "compartment_70616", "id": "reaction_10459764", "reactome": "R-DME-1483063", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_1524064" ], "products": [ "species_1524072", "species_1524067" ], "modifiers": [ [ "species_10459585", "catalyst" ] ], "additional_components": [ "FBgn0039360" ] }, "reaction_10479092": { "compartment": "compartment_17906", "id": "reaction_10479092", "reactome": "R-DME-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696066", "species_5696069" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10479089", "catalyst" ] ], "additional_components": [ "species_5696449", "species_114519", "species_1500590", "species_417891", "Q9VL10", "FBgn0260750", "species_29926" ] }, "reaction_10459840": { "compartment": "compartment_12045", "id": "reaction_10459840", "reactome": "R-DME-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10459837", "catalyst" ] ], "additional_components": [ "FBgn0287585" ] }, "reaction_10490948": { "compartment": "compartment_12045", "id": "reaction_10490948", "reactome": "R-DME-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10490945", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36313", "CHEBI:36314", "FBgn0039681" ] }, "reaction_10459577": { "compartment": "compartment_12045", "id": "reaction_10459577", "reactome": "R-DME-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10459574", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q0KHU5", "FBgn0052699", "Q6NN55", "FBgn0033476" ] }, "reaction_10459688": { "compartment": "compartment_12045", "id": "reaction_10459688", "reactome": "R-DME-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10460328": { "compartment": "compartment_984", "id": "reaction_10460328", "reactome": "R-DME-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10460293", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9W3I8", "FBgn0030013", "Q9VYG9", "FBgn0250862", "Q7JX94", "FBgn0050503", "Q9W4I0", "FBgn0029720", "Q6XPX3", "FBgn0033170", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459591": { "compartment": "compartment_12045", "id": "reaction_10459591", "reactome": "R-DME-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10459574", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q0KHU5", "FBgn0052699", "Q6NN55", "FBgn0033476" ] }, "reaction_10460326": { "compartment": "compartment_984", "id": "reaction_10460326", "reactome": "R-DME-1602399", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10455770", "catalyst" ] ], "additional_components": [ "FBgn0036939" ] }, "reaction_10459698": { "compartment": "compartment_12045", "id": "reaction_10459698", "reactome": "R-DME-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10459613": { "compartment": "compartment_12045", "id": "reaction_10459613", "reactome": "R-DME-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10432542", "catalyst" ] ], "additional_components": [ "FBgn0052699" ] }, "reaction_10459580": { "compartment": "compartment_12045", "id": "reaction_10459580", "reactome": "R-DME-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10432542", "catalyst" ] ], "additional_components": [ "FBgn0052699" ] }, "reaction_10459658": { "compartment": "compartment_70616", "id": "reaction_10459658", "reactome": "R-DME-1482689", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524027", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10459585", "catalyst" ] ], "additional_components": [ "FBgn0039360" ] }, "reaction_10460313": { "compartment": "compartment_984", "id": "reaction_10460313", "reactome": "R-DME-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602402" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10460293", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9W3I8", "FBgn0030013", "Q9VYG9", "FBgn0250862", "Q7JX94", "FBgn0050503", "Q9W4I0", "FBgn0029720", "Q6XPX3", "FBgn0033170", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459716": { "compartment": "compartment_12045", "id": "reaction_10459716", "reactome": "R-DME-1482907", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10459588": { "compartment": "compartment_70616", "id": "reaction_10459588", "reactome": "R-DME-1482546", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524047", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10459585", "catalyst" ] ], "additional_components": [ "FBgn0039360" ] }, "reaction_10459714": { "compartment": "compartment_12045", "id": "reaction_10459714", "reactome": "R-DME-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10459604", "catalyst" ] ], "additional_components": [ "FBgn0039655" ] }, "reaction_10459599": { "compartment": "compartment_12045", "id": "reaction_10459599", "reactome": "R-DME-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10459596", "catalyst" ] ], "additional_components": [ "FBgn0031815" ] }, "reaction_10459610": { "compartment": "compartment_12045", "id": "reaction_10459610", "reactome": "R-DME-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10459596", "catalyst" ] ], "additional_components": [ "FBgn0031815" ] }, "reaction_10459700": { "compartment": "compartment_12045", "id": "reaction_10459700", "reactome": "R-DME-1482868", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10460321": { "compartment": "compartment_984", "id": "reaction_10460321", "reactome": "R-DME-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_426658" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10460316", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459646": { "compartment": "compartment_70101", "id": "reaction_10459646", "reactome": "R-DME-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10459604", "catalyst" ] ], "additional_components": [ "FBgn0039655" ] }, "reaction_10459832": { "compartment": "compartment_12045", "id": "reaction_10459832", "reactome": "R-DME-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10459827", "catalyst" ] ], "additional_components": [ "FBgn0286511" ] }, "reaction_10459607": { "compartment": "compartment_17906", "id": "reaction_10459607", "reactome": "R-DME-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500590" ], "products": [ "species_1500580", "species_1524103" ], "modifiers": [ [ "species_10459604", "catalyst" ] ], "additional_components": [ "FBgn0039655" ] }, "reaction_10481009": { "compartment": "compartment_876", "id": "reaction_10481009", "reactome": "R-DME-6792445", "name": "LIPH, I hydrolyse PA to 2-acyl LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_6792472", "species_1602366" ], "modifiers": [ [ "species_10481006", "catalyst" ] ], "additional_components": [ "Q9VU78", "FBgn0036367", "Q9VRW5", "FBgn0035697", "Q9VLU1", "FBgn0031976", "Q9VJH1", "FBgn0032612", "Q9VEY9", "FBgn0038398", "Q9VBQ2", "FBgn0039344", "Q9VB94", "FBgn0039470", "Q9VB93", "FBgn0039471", "Q9VB92", "FBgn0039472", "Q9VB91", "FBgn0039473", "Q9VB90", "FBgn0039474", "Q9VB89", "FBgn0039475", "Q9VB88", "FBgn0039476", "Q7K3Z8", "FBgn0032029", "Q4V566", "FBgn0085476", "Q0E8T1", "FBgn0250847", "P06607", "FBgn0004047", "P02844", "FBgn0005391", "P02843", "FBgn0004045", "M9NFL7", "FBgn0036977", "M9MRT1", "FBgn0032289", "A8DYT7", "FBgn0085477", "A1ZAL5", "FBgn0034166", "Q9W448", "FBgn0029831", "Q9W304", "FBgn0030162", "Q9VZN6", "FBgn0035453", "Q9VX70", "FBgn0265267", "Q9VX69", "FBgn0030828", "Q9VX01", "FBgn0030884" ] }, "reaction_10453360": { "compartment": "compartment_12045", "id": "reaction_10453360", "reactome": "R-DME-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_1500604", "species_76194" ], "modifiers": [ [ "species_10432535", "catalyst" ] ], "additional_components": [ "FBgn0031132" ] }, "reaction_10459662": { "compartment": "compartment_17906", "id": "reaction_10459662", "reactome": "R-DME-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10432552", "catalyst" ] ], "additional_components": [ "FBgn0027579" ] }, "reaction_10460330": { "compartment": "compartment_984", "id": "reaction_10460330", "reactome": "R-DME-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10460316", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10495095": { "compartment": "compartment_17906", "id": "reaction_10495095", "reactome": "R-DME-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10495077", "catalyst" ], [ "species_10495093", "catalyst" ] ], "additional_components": [ "Q9VKD7", "FBgn0261266", "Q9W3F7", "FBgn0030037" ] }, "reaction_10459655": { "compartment": "compartment_12045", "id": "reaction_10459655", "reactome": "R-DME-1482679", "name": "PA is hydrolysed to 1-acyl LPA by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10432547": { "compartment": "compartment_12045", "id": "reaction_10432547", "reactome": "R-DME-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10432544", "catalyst" ] ], "additional_components": [ "Q0KHU5", "FBgn0052699", "Q9VRC1", "FBgn0031132", "Q9VYJ4", "FBgn0030421", "Q7KTI0", "FBgn0026718", "D5AEK7", "FBgn0036623", "Q9VV49", "FBgn0036622" ] }, "reaction_10432609": { "compartment": "compartment_70101", "id": "reaction_10432609", "reactome": "R-DME-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75970", "species_73473" ], "products": [ "species_76114", "species_29360" ], "modifiers": [ [ "species_10432606", "catalyst" ] ], "additional_components": [ "P13706", "FBgn0001128", "Q9W1U3", "FBgn0034825", "Q8IN06", "FBgn0263048" ] }, "reaction_10493857": { "compartment": "compartment_984", "id": "reaction_10493857", "reactome": "R-DME-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2173763" ], "products": [ "species_8954142", "species_8952253" ], "modifiers": [ [ "species_10493854", "catalyst" ] ], "additional_components": [ "Q9I7L9", "FBgn0042175", "Q9Y168", "FBgn0051683" ] }, "reaction_10460319": { "compartment": "compartment_984", "id": "reaction_10460319", "reactome": "R-DME-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10460316", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459660": { "compartment": "compartment_12045", "id": "reaction_10459660", "reactome": "R-DME-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10459669": { "compartment": "compartment_12045", "id": "reaction_10459669", "reactome": "R-DME-1482776", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1524021", "species_1498724" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10459620": { "compartment": "compartment_12045", "id": "reaction_10459620", "reactome": "R-DME-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10459704": { "compartment": "compartment_12045", "id": "reaction_10459704", "reactome": "R-DME-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10459623": { "compartment": "compartment_12045", "id": "reaction_10459623", "reactome": "R-DME-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10479047": { "compartment": "compartment_70101", "id": "reaction_10479047", "reactome": "R-DME-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694568", "species_29356" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10479044", "catalyst" ] ], "additional_components": [ "FBgn0033226" ] }, "reaction_10459702": { "compartment": "compartment_12045", "id": "reaction_10459702", "reactome": "R-DME-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10460323": { "compartment": "compartment_984", "id": "reaction_10460323", "reactome": "R-DME-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602375", "species_109276" ], "products": [ "species_1602372", "species_1602366" ], "modifiers": [ [ "species_10460293", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9W3I8", "FBgn0030013", "Q9VYG9", "FBgn0250862", "Q7JX94", "FBgn0050503", "Q9W4I0", "FBgn0029720", "Q6XPX3", "FBgn0033170", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459648": { "compartment": "compartment_12045", "id": "reaction_10459648", "reactome": "R-DME-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10459787": { "compartment": "compartment_12045", "id": "reaction_10459787", "reactome": "R-DME-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10459784", "catalyst" ] ], "additional_components": [ "Q9W0D9", "FBgn0035231", "Q7K4C7", "FBgn0041342" ] }, "reaction_10443498": { "compartment": "compartment_70101", "id": "reaction_10443498", "reactome": "R-DME-264622", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_76183" ], "products": [ "species_264643", "species_76194" ], "modifiers": [ [ "species_10443495", "catalyst" ] ], "additional_components": [ "FBgn0000303" ] }, "reaction_10459817": { "compartment": "compartment_70101", "id": "reaction_10459817", "reactome": "R-DME-1483159", "name": "PCho is dephosphorylated to Cho by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524071" ], "products": [ "species_264618", "species_29372" ], "modifiers": [ [ "species_10459801", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VWF3", "FBgn0031045", "Q9VWF0", "FBgn0031048" ] }, "reaction_10491447": { "compartment": "compartment_12045", "id": "reaction_10491447", "reactome": "R-DME-8877153", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10491443" ], "products": [ "species_10491445" ], "modifiers": [], "additional_components": [ "FBgn0032513", "Q9VJZ2", "FBgn0032513", "species_429802" ] }, "reaction_10479012": { "compartment": "compartment_876", "id": "reaction_10479012", "reactome": "R-DME-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694502" ], "products": [ "species_5694457", "species_1861754" ], "modifiers": [ [ "species_10479009", "catalyst" ] ], "additional_components": [ "FBgn0033382" ] }, "reaction_10459761": { "compartment": "compartment_70101", "id": "reaction_10459761", "reactome": "R-DME-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10459758", "catalyst" ] ], "additional_components": [ "Q8IMF4", "FBgn0032955" ] }, "reaction_10465406": { "compartment": "compartment_161320", "id": "reaction_10465406", "reactome": "R-DME-2213240", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213221" ], "products": [ "species_2213225" ], "modifiers": [ [ "species_10465403", "catalyst" ] ], "additional_components": [ "Q9VCK1", "FBgn0039099", "Q95RA9", "FBgn0038149", "Q9VHA5", "FBgn0037721", "Q9VCK2", "FBgn0039098" ] }, "reaction_10465008": { "compartment": "compartment_161320", "id": "reaction_10465008", "reactome": "R-DME-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10465005", "catalyst" ] ], "additional_components": [ "Q9VN93", "FBgn0260462", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q7K485", "FBgn0029093" ] }, "reaction_10431263": { "compartment": "compartment_70101", "id": "reaction_10431263", "reactome": "R-DME-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111354", "species_113592", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_111369" ], "modifiers": [ [ "species_10431260", "catalyst" ] ], "additional_components": [ "FBgn0000052" ] }, "reaction_10434110": { "compartment": "compartment_70101", "id": "reaction_10434110", "reactome": "R-DME-111289", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434106" ], "products": [ "species_10431276" ], "modifiers": [ [ "species_73566", "catalyst" ] ], "additional_components": [ "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793", "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793" ] }, "reaction_10431198": { "compartment": "compartment_70101", "id": "reaction_10431198", "reactome": "R-DME-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10431195", "catalyst" ] ], "additional_components": [ "FBgn0000239" ] }, "reaction_10434142": { "compartment": "compartment_70101", "id": "reaction_10434142", "reactome": "R-DME-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10434139", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_35141", "inhibitor" ], [ "species_113578", "inhibitor" ] ], "additional_components": [ "species_29926", "Q9Y0Y2", "FBgn0027493" ] }, "reaction_10434108": { "compartment": "compartment_70101", "id": "reaction_10434108", "reactome": "R-DME-111285", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431276" ], "products": [ "species_10434106" ], "modifiers": [ [ "species_29602", "catalyst" ], [ "species_113578", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793", "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793" ] }, "reaction_10431224": { "compartment": "compartment_70101", "id": "reaction_10431224", "reactome": "R-DME-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419151", "species_111409" ], "products": [ "species_111355", "species_111427" ], "modifiers": [ [ "species_10431218", "catalyst" ] ], "additional_components": [ "Q9VC18", "FBgn0039241" ] }, "reaction_10431255": { "compartment": "compartment_70101", "id": "reaction_10431255", "reactome": "R-DME-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_29372", "species_111370", "species_29370" ], "modifiers": [ [ "species_10431252", "catalyst" ] ], "additional_components": [ "FBgn0000053" ] }, "reaction_10498472": { "compartment": "compartment_70101", "id": "reaction_10498472", "reactome": "R-DME-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10431205" ], "products": [ "species_10431208" ], "modifiers": [], "additional_components": [ "Q07152", "FBgn0003204", "Q07152", "FBgn0003204" ] }, "reaction_10431221": { "compartment": "compartment_70101", "id": "reaction_10431221", "reactome": "R-DME-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29356", "species_29602" ], "modifiers": [ [ "species_10431218", "catalyst" ] ], "additional_components": [ "Q9VC18", "FBgn0039241" ] }, "reaction_10431281": { "compartment": "compartment_70101", "id": "reaction_10431281", "reactome": "R-DME-73828", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_35141" ], "products": [ "species_29586", "species_76577" ], "modifiers": [ [ "species_10431231", "catalyst" ] ], "additional_components": [ "Q9VEP6", "FBgn0038467" ] }, "reaction_10431279": { "compartment": "compartment_70101", "id": "reaction_10431279", "reactome": "R-DME-73815", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_29356", "species_29472" ], "products": [ "species_111294", "species_111292", "species_29404" ], "modifiers": [ [ "species_10431276", "catalyst" ] ], "additional_components": [ "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793" ] }, "reaction_10431247": { "compartment": "compartment_70101", "id": "reaction_10431247", "reactome": "R-DME-73806", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111370", "species_113528" ], "products": [ "species_111395" ], "modifiers": [ [ "species_10431241", "catalyst" ] ], "additional_components": [ "Q9I7S8", "FBgn0020513" ] }, "reaction_10431244": { "compartment": "compartment_70101", "id": "reaction_10431244", "reactome": "R-DME-73805", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29448", "species_111395" ], "products": [ "species_29372", "species_29370", "species_111399" ], "modifiers": [ [ "species_10431241", "catalyst" ] ], "additional_components": [ "Q9I7S8", "FBgn0020513" ] }, "reaction_10431210": { "compartment": "compartment_70101", "id": "reaction_10431210", "reactome": "R-DME-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29602", "species_29360" ], "products": [ "species_70106", "species_111584", "species_73473" ], "modifiers": [ [ "species_10431205", "catalyst" ], [ "species_10431208", "inhibitor" ], [ "species_111584", "inhibitor" ] ], "additional_components": [ "Q07152", "FBgn0003204", "Q07152", "FBgn0003204" ] }, "reaction_10431269": { "compartment": "compartment_70101", "id": "reaction_10431269", "reactome": "R-DME-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111292", "species_113592", "species_29424" ], "products": [ "species_29372", "species_111338", "species_29370" ], "modifiers": [ [ "species_10431252", "catalyst" ] ], "additional_components": [ "FBgn0000053" ] }, "reaction_10431266": { "compartment": "compartment_70101", "id": "reaction_10431266", "reactome": "R-DME-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_111354", "species_111355" ], "modifiers": [ [ "species_10431252", "catalyst" ] ], "additional_components": [ "FBgn0000053" ] }, "reaction_10431234": { "compartment": "compartment_70101", "id": "reaction_10431234", "reactome": "R-DME-73800", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111399" ], "products": [ "species_29586", "species_111409" ], "modifiers": [ [ "species_10431231", "catalyst" ] ], "additional_components": [ "Q9VEP6", "FBgn0038467" ] }, "reaction_10498768": { "compartment": "compartment_70101", "id": "reaction_10498768", "reactome": "R-DME-9708536", "name": "HMOX1 translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497417" ], "products": [ "species_10498766" ], "modifiers": [], "additional_components": [ "FBgn0037933", "FBgn0037933" ] }, "reaction_10498774": { "compartment": "compartment_70101", "id": "reaction_10498774", "reactome": "R-DME-9708558", "name": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439555" ], "products": [ "species_10498772" ], "modifiers": [], "additional_components": [ "Q9VGJ9", "FBgn0037933", "Q9VGJ9", "FBgn0037933" ] }, "reaction_10498760": { "compartment": "compartment_12045", "id": "reaction_10498760", "reactome": "R-DME-9708457", "name": "HM13 cleaves HMOX1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439555" ], "products": [ "species_10497417" ], "modifiers": [ [ "species_10498757", "catalyst" ] ], "additional_components": [ "Q9VGJ9", "FBgn0037933", "FBgn0037933", "FBgn0031260" ] }, "reaction_10498762": { "compartment": "compartment_70101", "id": "reaction_10498762", "reactome": "R-DME-9708466", "name": "BACH1 translocates from the nucleoplasm to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498736" ], "products": [ "species_10498744" ], "modifiers": [ [ "species_3785707", "catalyst" ] ], "additional_components": [ "FBgn0030417", "FBgn0030417" ] }, "reaction_10491908": { "compartment": "compartment_70101", "id": "reaction_10491908", "reactome": "R-DME-8932327", "name": "NFE2L2 binds KEAP1:CUL3:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491902", "species_10491904" ], "products": [ "species_10491906" ], "modifiers": [], "additional_components": [ "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975" ] }, "reaction_10498789": { "compartment": "compartment_70101", "id": "reaction_10498789", "reactome": "R-DME-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9714134", "species_10491906" ], "products": [ "species_10498787" ], "modifiers": [], "additional_components": [ "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975" ] }, "reaction_10491912": { "compartment": "compartment_70101", "id": "reaction_10491912", "reactome": "R-DME-8932334", "name": "KEAP1:CUL3:RBX1:NFE2L2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491906", "species_10491904" ], "products": [ "species_10491902", "species_10491910" ], "modifiers": [], "additional_components": [ "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268" ] }, "reaction_10491900": { "compartment": "compartment_70101", "id": "reaction_10491900", "reactome": "R-DME-8932309", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491892" ], "products": [ "species_10491898" ], "modifiers": [], "additional_components": [] }, "reaction_10491917": { "compartment": "compartment_70101", "id": "reaction_10491917", "reactome": "R-DME-8932351", "name": "KEAP1 facilitates ubiquitination of NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10491906" ], "products": [ "species_10491914", "species_10491904" ], "modifiers": [ [ "species_10491906", "catalyst" ], [ "species_1250243", "inhibitor" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P20482", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975" ] }, "reaction_10491919": { "compartment": "compartment_70101", "id": "reaction_10491919", "reactome": "R-DME-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491914" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P20482", "FBgn0262975", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10439548": { "compartment": "compartment_70101", "id": "reaction_10439548", "reactome": "R-DME-189384", "name": "BLVRA:Zn2+, BLVRB reduce BV to BIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189396", "species_29364" ], "products": [ "species_189386", "species_29366" ], "modifiers": [ [ "species_10439545", "catalyst" ] ], "additional_components": [ "FBgn0037749" ] }, "reaction_10439562": { "compartment": "compartment_70101", "id": "reaction_10439562", "reactome": "R-DME-189398", "name": "HMOX1 dimer, HMOX2 cleave heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364", "species_71185" ], "products": [ "species_29356", "species_189385", "species_71067", "species_189396", "species_29366" ], "modifiers": [ [ "species_10439559", "catalyst" ] ], "additional_components": [ "Q9VGJ9", "FBgn0037933" ] }, "reaction_10436293": { "compartment": "compartment_70616", "id": "reaction_10436293", "reactome": "R-DME-163214", "name": "Electron transfer from reduced cytochrome c to molecular oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_10436148", "species_113529" ], "products": [ "species_10436150", "species_163953", "species_113521" ], "modifiers": [ [ "species_10436237", "catalyst" ], [ "species_10436243", "catalyst" ], [ "species_10436265", "catalyst" ], [ "species_10436289", "catalyst" ], [ "species_10436291", "inhibitor" ] ], "additional_components": [ "CHEBI:38573", "P84029", "FBgn0284248", "CHEBI:38574", "P84029", "FBgn0284248", "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "FBgn0260222", "Q9VF98", "FBgn0011476", "Q9VMQ6", "FBgn0051648", "Q9VST8", "FBgn0035960", "Q9VG00", "FBgn0002354", "Q9VL11", "FBgn0032205", "Q9VJ86", "FBgn0284256", "Q9U4F3", "FBgn0029117", "Q9VMX4", "FBgn0262467", "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "species_9709326" ] }, "reaction_10498783": { "compartment": "compartment_70616", "id": "reaction_10498783", "reactome": "R-DME-9709406", "name": "CO binds to Cytochrome c oxidase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9709326", "species_10436237" ], "products": [ "species_10436291" ], "modifiers": [], "additional_components": [ "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "species_9709326" ] }, "reaction_10498367": { "compartment": "compartment_70101", "id": "reaction_10498367", "reactome": "R-DME-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10443830", "catalyst" ] ], "additional_components": [ "FBgn0032456" ] }, "reaction_10445949": { "compartment": "compartment_12045", "id": "reaction_10445949", "reactome": "R-DME-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445937" ], "products": [ "species_10445939" ], "modifiers": [], "additional_components": [ "FBgn0261984", "A8JR46", "FBgn0261984" ] }, "reaction_10445947": { "compartment": "compartment_12045", "id": "reaction_10445947", "reactome": "R-DME-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445939", "species_113592" ], "products": [ "species_29370", "species_10445944" ], "modifiers": [ [ "species_10445939", "catalyst" ] ], "additional_components": [ "A8JR46", "FBgn0261984", "A8JR46", "FBgn0261984", "A8JR46", "FBgn0261984" ] }, "reaction_10498384": { "compartment": "compartment_70101", "id": "reaction_10498384", "reactome": "R-DME-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498382" ], "products": [ "species_189386", "species_10471582" ], "modifiers": [], "additional_components": [ "Q8INK3", "FBgn0037913", "species_9661418", "FBgn0037913" ] }, "reaction_10498386": { "compartment": "compartment_70101", "id": "reaction_10498386", "reactome": "R-DME-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10471582" ], "products": [ "species_10498382" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_9661418" ] }, "reaction_10498370": { "compartment": "compartment_70101", "id": "reaction_10498370", "reactome": "R-DME-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10455124", "catalyst" ] ], "additional_components": [ "CHEBI:18392", "CHEBI:16427", "CHEBI:16427", "CHEBI:18392", "P45843", "FBgn0003515", "P12428", "FBgn0000241", "Q0KI14", "FBgn0051121" ] }, "reaction_10498375": { "compartment": "compartment_876", "id": "reaction_10498375", "reactome": "R-DME-9661723", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10498372", "catalyst" ] ], "additional_components": [ "FBgn0032123" ] }, "reaction_10498380": { "compartment": "compartment_70101", "id": "reaction_10498380", "reactome": "R-DME-9661799", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10498377", "catalyst" ] ], "additional_components": [ "FBgn0032123" ] }, "reaction_10498365": { "compartment": "compartment_70101", "id": "reaction_10498365", "reactome": "R-DME-9661397", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10454191", "catalyst" ] ], "additional_components": [ "FBgn0032123" ] }, "reaction_10486017": { "compartment": "compartment_7660", "id": "reaction_10486017", "reactome": "R-DME-6804441", "name": "RNF34 or RFFL ubiquitinates phosphorylated TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10427430" ], "products": [ "species_10486010" ], "modifiers": [ [ "species_10486012", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8IMZ4", "FBgn0039044", "FBgn0033783" ] }, "reaction_10481097": { "compartment": "compartment_70101", "id": "reaction_10481097", "reactome": "R-DME-6793685", "name": "Ubiquitinated TP53 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467609" ], "products": [ "species_10481095" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10467619": { "compartment": "compartment_7660", "id": "reaction_10467619", "reactome": "R-DME-3215310", "name": "USP7 deubiquitinates TP53 and counteracts MDM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10467609" ], "products": [ "species_10427430", "species_10467611" ], "modifiers": [ [ "species_10467616", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8IMZ4", "FBgn0039044", "FBgn0030366" ] }, "reaction_10495584": { "compartment": "compartment_70101", "id": "reaction_10495584", "reactome": "R-DME-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495580" ], "products": [ "species_10495578", "species_29368" ], "modifiers": [], "additional_components": [ "species_113535", "species_71185", "Q9VF15", "FBgn0027657", "species_71185", "Q9VF15", "FBgn0027657" ] }, "reaction_10495582": { "compartment": "compartment_70101", "id": "reaction_10495582", "reactome": "R-DME-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495578", "species_29368" ], "products": [ "species_10495580" ], "modifiers": [], "additional_components": [ "species_71185", "Q9VF15", "FBgn0027657", "species_113535", "species_71185", "Q9VF15", "FBgn0027657" ] }, "reaction_10471496": { "compartment": "compartment_70101", "id": "reaction_10471496", "reactome": "R-DME-5263616", "name": "MeSeO2H is reduced to MeSeOH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357694", "species_70106", "species_29364" ], "products": [ "species_5357663", "species_29356", "species_29366" ], "modifiers": [ [ "species_10431010", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VNT5", "FBgn0037170", "P91938", "FBgn0020653" ] }, "reaction_10471493": { "compartment": "compartment_70101", "id": "reaction_10471493", "reactome": "R-DME-5263614", "name": "MeSeOH is reduced to MeSeH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357663", "species_70106", "species_29364" ], "products": [ "species_29356", "species_29366", "species_5357669" ], "modifiers": [ [ "species_10431010", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VNT5", "FBgn0037170", "P91938", "FBgn0020653" ] }, "reaction_10464075": { "compartment": "compartment_70101", "id": "reaction_10464075", "reactome": "R-DME-2025890", "name": "Calcineurin binds NFATC1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10464021", "species_10464038", "species_74016" ], "products": [ "species_10464073" ], "modifiers": [], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505" ] }, "reaction_10498551": { "compartment": "compartment_70101", "id": "reaction_10498551", "reactome": "R-DME-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678991", "species_10437068" ], "products": [ "species_10498549" ], "modifiers": [], "additional_components": [ "FBgn0013954", "P48375", "FBgn0013954" ] }, "reaction_10495732": { "compartment": "compartment_70101", "id": "reaction_10495732", "reactome": "R-DME-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495726", "species_10495728" ], "products": [ "species_10495730" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10495748": { "compartment": "compartment_70101", "id": "reaction_10495748", "reactome": "R-DME-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495730" ], "products": [ "species_10495746" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495777": { "compartment": "compartment_70101", "id": "reaction_10495777", "reactome": "R-DME-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495769" ], "products": [ "species_10495775" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495763": { "compartment": "compartment_70101", "id": "reaction_10495763", "reactome": "R-DME-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495759" ], "products": [ "species_10495761" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10495767": { "compartment": "compartment_70101", "id": "reaction_10495767", "reactome": "R-DME-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495726" ], "products": [ "species_10495765" ], "modifiers": [], "additional_components": [] }, "reaction_10495771": { "compartment": "compartment_70101", "id": "reaction_10495771", "reactome": "R-DME-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495759", "species_10495728" ], "products": [ "species_10495769" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10458684": { "compartment": "compartment_876", "id": "reaction_10458684", "reactome": "R-DME-1296043", "name": "Activation of HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458681", "catalyst" ] ], "additional_components": [ "species_30389", "A1Z9N7", "FBgn0263397" ] }, "reaction_10458851": { "compartment": "compartment_876", "id": "reaction_10458851", "reactome": "R-DME-1297444", "name": "Binding of cAMP to HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458679", "species_30389" ], "products": [ "species_10458681" ], "modifiers": [], "additional_components": [ "A1Z9N7", "FBgn0263397", "species_30389", "A1Z9N7", "FBgn0263397" ] }, "reaction_10476866": { "compartment": "compartment_70101", "id": "reaction_10476866", "reactome": "R-DME-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10437507" ], "products": [ "species_10437505", "species_10437507" ], "modifiers": [ [ "species_10476863", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W422", "FBgn0029853" ] }, "reaction_10477104": { "compartment": "compartment_70101", "id": "reaction_10477104", "reactome": "R-DME-5689111", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456711", "species_10477101" ], "products": [ "species_10476869" ], "modifiers": [ [ "species_10456711", "catalyst" ] ], "additional_components": [ "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0041100", "FBgn0041100" ] }, "reaction_10459500": { "compartment": "compartment_70101", "id": "reaction_10459500", "reactome": "R-DME-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10459493", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10459498": { "compartment": "compartment_876", "id": "reaction_10459498", "reactome": "R-DME-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10459454", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9V9Y6", "FBgn0040629", "Q8IMV4", "FBgn0039235", "Q4V4S9", "FBgn0038956", "Q9VTU8", "FBgn0027843", "Q9VH26", "FBgn0037788", "Q9VB76", "FBgn0039486", "Q9V9Y8", "FBgn0039838" ] }, "reaction_10459496": { "compartment": "compartment_70101", "id": "reaction_10459496", "reactome": "R-DME-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10459493", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10459523": { "compartment": "compartment_5460", "id": "reaction_10459523", "reactome": "R-DME-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_29376" ], "products": [ "species_29896", "species_113529" ], "modifiers": [ [ "species_10459518", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10458226": { "compartment": "compartment_984", "id": "reaction_10458226", "reactome": "R-DME-1237045", "name": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10458223", "catalyst" ] ], "additional_components": [ "Q4V4S9", "FBgn0038956", "Q9V9Y8", "FBgn0039838", "Q9VTU8", "FBgn0027843", "Q9V9Y6", "FBgn0040629", "Q9VH26", "FBgn0037788", "Q8IMV4", "FBgn0039235", "Q9VB76", "FBgn0039486", "species_1562550" ] }, "reaction_10459457": { "compartment": "compartment_876", "id": "reaction_10459457", "reactome": "R-DME-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10459454", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9V9Y6", "FBgn0040629", "Q8IMV4", "FBgn0039235", "Q4V4S9", "FBgn0038956", "Q9VTU8", "FBgn0027843", "Q9VH26", "FBgn0037788", "Q9VB76", "FBgn0039486", "Q9V9Y8", "FBgn0039838" ] }, "reaction_10459521": { "compartment": "compartment_5460", "id": "reaction_10459521", "reactome": "R-DME-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29896", "species_113529" ], "products": [ "species_113521", "species_29376" ], "modifiers": [ [ "species_10459518", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10458241": { "compartment": "compartment_984", "id": "reaction_10458241", "reactome": "R-DME-1237081", "name": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10458223", "catalyst" ] ], "additional_components": [ "Q4V4S9", "FBgn0038956", "Q9V9Y8", "FBgn0039838", "Q9VTU8", "FBgn0027843", "Q9V9Y6", "FBgn0040629", "Q9VH26", "FBgn0037788", "Q8IMV4", "FBgn0039235", "Q9VB76", "FBgn0039486", "species_1562550" ] }, "reaction_10444363": { "compartment": "compartment_876", "id": "reaction_10444363", "reactome": "R-DME-372529", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444322" ], "products": [ "species_10443025", "species_10442919", "species_10444360", "species_10443003", "species_10443019", "species_10442973", "species_10443023", "species_372533" ], "modifiers": [ [ "species_10444322", "catalyst" ] ], "additional_components": [ "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0004574", "FBgn0270928", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343" ] }, "reaction_10444325": { "compartment": "compartment_70101", "id": "reaction_10444325", "reactome": "R-DME-372505", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10442919", "species_10442968", "species_10443003", "species_10442973", "species_10443487" ], "products": [ "species_10444322" ], "modifiers": [ [ "species_10443487", "catalyst" ] ], "additional_components": [ "FBgn0013343", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660" ] }, "reaction_10443490": { "compartment": "compartment_70101", "id": "reaction_10443490", "reactome": "R-DME-264615", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372511", "species_264643", "species_10443485" ], "products": [ "species_70106", "species_10443487" ], "modifiers": [ [ "species_10443479", "catalyst" ] ], "additional_components": [ "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "FBgn0270928" ] }, "reaction_10427772": { "compartment": "compartment_70101", "id": "reaction_10427772", "reactome": "R-DME-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427770" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10427800": { "compartment": "compartment_7660", "id": "reaction_10427800", "reactome": "R-DME-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427741" ], "products": [ "species_113582", "species_10427778" ], "modifiers": [ [ "species_10427797", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "FBgn0019686" ] }, "reaction_10498677": { "compartment": "compartment_70101", "id": "reaction_10498677", "reactome": "R-DME-9698844", "name": "MLKL binds HSP90:CDC37", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471010", "species_10462118", "species_10462120" ], "products": [ "species_10498675" ], "modifiers": [], "additional_components": [ "Q24276", "FBgn0011573", "P02828", "FBgn0001233", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P11346", "Raf" ] }, "reaction_10476089": { "compartment": "compartment_70101", "id": "reaction_10476089", "reactome": "R-DME-5675470", "name": "BIRC2/3 (cIAP1/2) is autoubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454480", "species_10471711" ], "products": [ "species_10476086" ], "modifiers": [ [ "species_10471711", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10440446": { "compartment": "compartment_876", "id": "reaction_10440446", "reactome": "R-DME-194187", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440408", "species_192483", "species_74113" ], "products": [ "species_83910", "species_10440410" ], "modifiers": [ [ "species_10440422", "catalyst" ], [ "species_10440444", "catalyst" ] ], "additional_components": [ "FBgn0037913", "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q8INK3", "FBgn0037913", "species_193473", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:16755", "CHEBI:28865", "Q9VXF5", "FBgn0030756", "Q9VXV4", "FBgn0030638", "P20153", "FBgn0003964", "M9ND53", "FBgn0041092", "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546" ] }, "reaction_10471675": { "compartment": "compartment_7660", "id": "reaction_10471675", "reactome": "R-DME-5340251", "name": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440435", "species_10440440", "species_10440442", "species_10440428" ], "products": [ "species_10440444" ], "modifiers": [], "additional_components": [ "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546", "FBgn0041092", "FBgn0041092", "FBgn0003964", "P20153", "FBgn0003964", "M9ND53", "FBgn0041092", "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546" ] }, "reaction_10471673": { "compartment": "compartment_7660", "id": "reaction_10471673", "reactome": "R-DME-5340195", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440433", "species_5340249" ], "products": [ "species_10440435" ], "modifiers": [], "additional_components": [ "FBgn0000546", "species_176655", "CHEBI:16755", "CHEBI:28834", "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546" ] }, "reaction_10435765": { "compartment": "compartment_70101", "id": "reaction_10435765", "reactome": "R-DME-159425", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_194096" ], "products": [ "species_111294", "species_29356", "species_194073", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "species_193473", "CHEBI:16755", "CHEBI:15519", "CHEBI:28701", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10458872": { "compartment": "compartment_876", "id": "reaction_10458872", "reactome": "R-DME-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458869", "catalyst" ] ], "additional_components": [ "Q9VHE0", "FBgn0037690", "Q9VFS9", "FBgn0038165" ] }, "reaction_10491685": { "compartment": "compartment_12045", "id": "reaction_10491685", "reactome": "R-DME-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491672" ], "products": [ "species_29420", "species_10491676", "species_10491105" ], "modifiers": [ [ "species_10491682", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9W4A0", "FBgn0015794", "species_29420", "Q9W4A0", "FBgn0015794", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935" ] }, "reaction_10491494": { "compartment": "compartment_17938", "id": "reaction_10491494", "reactome": "R-DME-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491471", "species_29438" ], "products": [ "species_29420", "species_10491477", "species_10491105" ], "modifiers": [ [ "species_10491491", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "O76742", "FBgn0015795", "species_29420", "O76742", "FBgn0015795", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VZL5", "FBgn0035470", "Q9VR38", "FBgn0031640" ] }, "reaction_10491114": { "compartment": "compartment_216813", "id": "reaction_10491114", "reactome": "R-DME-8875318", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491107" ], "products": [ "species_29420", "species_10491111", "species_10491105" ], "modifiers": [ [ "species_10474299", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29420", "P25228", "FBgn0005586", "P25228", "FBgn0005586", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0030613" ] }, "reaction_10491402": { "compartment": "compartment_70101", "id": "reaction_10491402", "reactome": "R-DME-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491388" ], "products": [ "species_29420", "species_10491105", "species_10491392" ], "modifiers": [ [ "species_10491397", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q86BK8", "FBgn0015791", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29438", "Q86BK8", "FBgn0015791", "FBgn0029756" ] }, "reaction_10491435": { "compartment": "compartment_171062", "id": "reaction_10491435", "reactome": "R-DME-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491424" ], "products": [ "species_29420", "species_10491428", "species_10491105" ], "modifiers": [ [ "species_10491430", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q7PLE9", "FBgn0039966", "species_29420", "Q7PLE9", "FBgn0039966", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0025802" ] }, "reaction_10491467": { "compartment": "compartment_5668575", "id": "reaction_10491467", "reactome": "R-DME-8877308", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491455", "species_29438" ], "products": [ "species_29420", "species_10491465", "species_10491105" ], "modifiers": [ [ "species_10474299", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "O76901", "FBgn0025382", "species_29420", "O76901", "FBgn0025382", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0030613" ] }, "reaction_10491217": { "compartment": "compartment_437051", "id": "reaction_10491217", "reactome": "R-DME-8876188", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491201" ], "products": [ "species_29420", "species_10491205", "species_10491105" ], "modifiers": [ [ "species_10491210", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "O15971", "FBgn0015789", "species_29420", "O15971", "FBgn0015789", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0025864" ] }, "reaction_10491569": { "compartment": "compartment_262783", "id": "reaction_10491569", "reactome": "R-DME-8877612", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491547" ], "products": [ "species_10491551", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491566", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9W5X0", "FBgn0031090", "species_29420", "Q9W5X0", "FBgn0031090", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "A1Z7Q5", "FBgn0027561", "P92177", "14-3-3epsilon" ] }, "reaction_10491634": { "compartment": "compartment_20699", "id": "reaction_10491634", "reactome": "R-DME-8877813", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491618" ], "products": [ "species_29420", "species_10491624", "species_10491105" ], "modifiers": [ [ "species_10491629", "catalyst" ] ], "additional_components": [ "Q9W3Q0", "FBgn0029959", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9W3Q0", "FBgn0029959", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0035229" ] }, "reaction_10491155": { "compartment": "compartment_171062", "id": "reaction_10491155", "reactome": "R-DME-8875320", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491118", "species_29438" ], "products": [ "species_29420", "species_10491126", "species_10491105" ], "modifiers": [ [ "species_10491152", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9V3I2", "FBgn0014010", "species_29420", "Q9V3I2", "FBgn0014010", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VNZ8", "FBgn0037116", "Q8MQW8", "FBgn0085443", "Q9W0H9", "FBgn0262937", "Q9VZ08", "FBgn0030286" ] }, "reaction_10491318": { "compartment": "compartment_262783", "id": "reaction_10491318", "reactome": "R-DME-8876454", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491291" ], "products": [ "species_29420", "species_10491105", "species_10491313" ], "modifiers": [ [ "species_10491315", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q8IRK9", "FBgn0067052", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q9VC31", "FBgn0051118", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "Q9VQG6", "FBgn0031460", "Q8IRK8", "FBgn0052673", "Q9VZ47", "FBgn0052671", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29438", "Q8IRK8", "FBgn0052673", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "Q9VQG6", "FBgn0031460", "Q9VZ47", "FBgn0052671", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "Q9W3D3", "FBgn0025864" ] }, "reaction_10491543": { "compartment": "compartment_13946", "id": "reaction_10491543", "reactome": "R-DME-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491502", "species_29438" ], "products": [ "species_10491516", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491540", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29420", "O18332", "FBgn0285937", "O18332", "FBgn0285937", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VLI9", "FBgn0260861", "Q8IRE3", "FBgn0286567", "Q9VSY8", "FBgn0260859", "Q9VPB6", "FBgn0037022", "A1Z8I0", "FBgn0033605", "Q95TN1", "FBgn0032204", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VW22", "FBgn0260655", "Q9VFB7", "FBgn0038303", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "Q7K2Q8", "FBgn0266723" ] }, "reaction_10491287": { "compartment": "compartment_70101", "id": "reaction_10491287", "reactome": "R-DME-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10491280" ], "products": [ "species_29370", "species_10491284" ], "modifiers": [ [ "species_10475687", "catalyst" ] ], "additional_components": [ "FBgn0025864", "FBgn0025864", "FBgn0260945" ] }, "reaction_10491384": { "compartment": "compartment_204883", "id": "reaction_10491384", "reactome": "R-DME-8876615", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491352" ], "products": [ "species_10491374", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491381", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29420", "Q9VQG6", "FBgn0031460", "O18338", "FBgn0262518", "Q9VZ47", "FBgn0052671", "Q8IR98", "FBgn0052670", "Q9W2S9", "FBgn0030221", "Q8IRK8", "FBgn0052673", "Q9W2V3", "FBgn0030200", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "Q9VQG6", "FBgn0031460", "Q9VZ47", "FBgn0052671", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "Q8IRK8", "FBgn0052673", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868" ] }, "reaction_10491960": { "compartment": "compartment_70101", "id": "reaction_10491960", "reactome": "R-DME-8933446", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10491553" ], "products": [ "species_29370", "species_10491559" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0027561", "FBgn0027561" ] }, "reaction_10491962": { "compartment": "compartment_70101", "id": "reaction_10491962", "reactome": "R-DME-8933452", "name": "YWHAE dimer binds phosphorylated DENND1 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432016", "species_10491559" ], "products": [ "species_10491564" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "FBgn0027561", "A1Z7Q5", "FBgn0027561", "P92177", "14-3-3epsilon" ] }, "reaction_10491614": { "compartment": "compartment_5668575", "id": "reaction_10491614", "reactome": "R-DME-8877760", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491593" ], "products": [ "species_10491599", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491611", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "A1Z7S3", "FBgn0002567", "species_29420", "A1Z7S3", "FBgn0002567", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q7K3N1", "FBgn0033973", "A1ZAX8", "FBgn0034261" ] }, "reaction_10490413": { "compartment": "compartment_7660", "id": "reaction_10490413", "reactome": "R-DME-8869568", "name": "NPM1 binds TFAP2A homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489710", "species_10469613" ], "products": [ "species_10490411" ], "modifiers": [ [ "species_5334804", "catalyst" ] ], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0016685", "Q27415", "FBgn0016685", "M9PIH9", "FBgn0261953" ] }, "reaction_10428447": { "compartment": "compartment_5460", "id": "reaction_10428447", "reactome": "R-DME-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70858", "species_113521" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10428381": { "compartment": "compartment_5460", "id": "reaction_10428381", "reactome": "R-DME-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10428378", "catalyst" ] ], "additional_components": [ "Q9VSL9", "FBgn0035911", "species_113596" ] }, "reaction_10453146": { "compartment": "compartment_5460", "id": "reaction_10453146", "reactome": "R-DME-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_30004", "species_29362" ], "products": [ "species_113526", "species_573404" ], "modifiers": [ [ "species_10428462", "catalyst" ] ], "additional_components": [ "Q9V8M5", "FBgn0034390" ] }, "reaction_10428473": { "compartment": "compartment_5460", "id": "reaction_10428473", "reactome": "R-DME-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428470", "catalyst" ] ], "additional_components": [ "FBgn0023537" ] }, "reaction_10453144": { "compartment": "compartment_5460", "id": "reaction_10453144", "reactome": "R-DME-508369", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_70836", "species_29362" ], "products": [ "species_70829", "species_113526" ], "modifiers": [ [ "species_10428424", "catalyst" ] ], "additional_components": [ "O18404", "FBgn0021765" ] }, "reaction_10428407": { "compartment": "compartment_5460", "id": "reaction_10428407", "reactome": "R-DME-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10428404", "catalyst" ] ], "additional_components": [ "A1Z934", "FBgn0033761" ] }, "reaction_10453142": { "compartment": "compartment_5460", "id": "reaction_10453142", "reactome": "R-DME-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70772", "species_113521" ], "products": [ "species_70744", "species_29896", "species_113593" ], "modifiers": [ [ "species_10428394", "catalyst" ] ], "additional_components": [ "Q9V9T5", "FBgn0039877", "Q9V9A7", "FBgn0042083" ] }, "reaction_10428437": { "compartment": "compartment_5460", "id": "reaction_10428437", "reactome": "R-DME-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10428434", "catalyst" ] ], "additional_components": [ "Q9W3N9", "FBgn0029969" ] }, "reaction_10428371": { "compartment": "compartment_5460", "id": "reaction_10428371", "reactome": "R-DME-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_508181", "species_113552" ], "modifiers": [ [ "species_10428368", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29702", "species_351964", "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "Q9VYD5", "FBgn0030482" ] }, "reaction_10453134": { "compartment": "compartment_70101", "id": "reaction_10453134", "reactome": "R-DME-508189", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_508187" ], "products": [ "species_29406", "species_508182" ], "modifiers": [ [ "species_10428360", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:17865", "CHEBI:16530", "species_351964", "CHEBI:58045", "species_29702", "Q9VYD5", "FBgn0030482" ] }, "reaction_10428455": { "compartment": "compartment_5460", "id": "reaction_10428455", "reactome": "R-DME-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10428452", "catalyst" ] ], "additional_components": [ "FBgn0038326" ] }, "reaction_10428417": { "compartment": "compartment_5460", "id": "reaction_10428417", "reactome": "R-DME-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10428414", "catalyst" ] ], "additional_components": [ "Q9VVU1", "FBgn0036824", "species_113596" ] }, "reaction_10428352": { "compartment": "compartment_5460", "id": "reaction_10428352", "reactome": "R-DME-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_508181" ], "products": [ "species_29362", "species_508261", "species_29376" ], "modifiers": [ [ "species_10428349", "catalyst" ] ], "additional_components": [ "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "CHEBI:15479", "species_70715", "species_70718", "Q7PLE6", "FBgn0039993", "Q9VHB8", "FBgn0037709", "species_8878387", "Q9VXY3", "FBgn0030612", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10430201": { "compartment": "compartment_7660", "id": "reaction_10430201", "reactome": "R-DME-72180", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430194" ], "products": [ "species_10430001", "species_10430036", "species_10430196", "species_10430024" ], "modifiers": [ [ "species_10430198", "catalyst" ] ], "additional_components": [ "Q02427", "FBgn0260944", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7KNF2", "FBgn0005648", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q02427", "FBgn0260944", "Q7KNF2", "FBgn0005648", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962" ] }, "reaction_10434116": { "compartment": "compartment_7660", "id": "reaction_10434116", "reactome": "R-DME-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434112" ], "products": [ "species_10434114", "species_10433259" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554" ] }, "reaction_10460039": { "compartment": "compartment_7660", "id": "reaction_10460039", "reactome": "R-DME-1592240", "name": "Formation of NRF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460033", "species_10460035", "species_10460024", "species_10460029", "species_10460031" ], "products": [ "species_10460037" ], "modifiers": [], "additional_components": [ "FBgn0052343", "FBgn0052343", "FBgn0004510", "FBgn0052343", "FBgn0052343", "M9NFF9", "FBgn0052343", "Q04688", "FBgn0004510" ] }, "reaction_10476803": { "compartment": "compartment_5460", "id": "reaction_10476803", "reactome": "R-DME-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428209", "species_113526" ], "products": [ "species_10476793", "species_5688274" ], "modifiers": [ [ "species_10476800", "catalyst" ] ], "additional_components": [ "P54385", "FBgn0001098", "P54385", "FBgn0001098", "Q8IRR5", "FBgn0029783", "species_1562550" ] }, "reaction_10476835": { "compartment": "compartment_5460", "id": "reaction_10476835", "reactome": "R-DME-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476821", "species_113526" ], "products": [ "species_5688337", "species_10476825", "species_5688274" ], "modifiers": [ [ "species_10476832", "catalyst" ] ], "additional_components": [ "Q9VP61", "FBgn0012034", "Q00637", "FBgn0010213", "P54385", "FBgn0001098", "Q00637", "FBgn0010213", "Q9VP61", "FBgn0012034", "P54385", "FBgn0001098", "Q9I7I7", "FBgn0038788", "species_1562550" ] }, "reaction_10493564": { "compartment": "compartment_70616", "id": "reaction_10493564", "reactome": "R-DME-8949580", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436868" ], "products": [ "species_10493562" ], "modifiers": [], "additional_components": [ "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081" ] }, "reaction_10458847": { "compartment": "compartment_876", "id": "reaction_10458847", "reactome": "R-DME-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458844", "catalyst" ] ], "additional_components": [ "Q9VHE0", "FBgn0037690", "Q9VFS9", "FBgn0038165" ] }, "reaction_390116": { "compartment": "compartment_70101", "id": "reaction_390116", "reactome": "R-DME-390116", "name": "Phospho FT reduces D accumulation at the plasma membrane", "reversible": "false", "notes": "There are observations that Fat (FT), Dachsous (DS), and Four-jointed (FJ) modulate the subcellular localisation of Dachs (D). In the absence of FT, D accumulates at the plasma membrane. These suggest a simple model whereby signalling through FT regulates the stability of the serine/threonine kinase, Warts (WTS), by reducing protein levels of D at the plasma membrane so it fails to interact with WTS.", "reactants": [ "species_451851", "species_451889" ], "products": [ "species_390026", "species_451851" ], "modifiers": [], "additional_components": [ "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "FBgn0000411", "FBgn0000411", "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO" ] }, "reaction_451856": { "compartment": "compartment_70101", "id": "reaction_451856", "reactome": "R-DME-451856", "name": "FT is phosphorylated by DCO", "reversible": "false", "notes": "The casein kinase 1 epsilon orthologue, Discs overgrown (DCO) phosphorylates the cytoplasmic part of FT at unknown residues.", "reactants": [ "species_113592", "species_451827" ], "products": [ "species_451851", "species_29370" ], "modifiers": [ [ "species_451827", "catalyst" ] ], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS", "O76324", "DCO", "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "P33450", "Phospho FT", "Q24292", "DS", "O76324", "DCO" ] }, "reaction_451839": { "compartment": "compartment_70101", "id": "reaction_451839", "reactome": "R-DME-451839", "name": "DCO binds to FT", "reversible": "false", "notes": "Fat (FT) is cleaved in its extracellular domain at an unknown site with the two fragments produced remaining stably associated after processing. The casein kinase 1 epsilon orthologue, Discs overgrown (DCO) binds to the cytoplasmic part of FT.", "reactants": [ "species_350966", "species_205729" ], "products": [ "species_451827" ], "modifiers": [], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS", "P33450", "Phospho FT", "Q24292", "DS", "O76324", "DCO" ] }, "reaction_350440": { "compartment": "compartment_876", "id": "reaction_350440", "reactome": "R-DME-350440", "name": "FT binds to DS in an adjacent cell", "reversible": "false", "notes": "The transmembrane non-classical cadherin Fat (FT) binds extracellularly to the transmembrane non-classical cadherin Dachsous (DS) in adjacent cells.", "reactants": [ "species_351124", "species_351109" ], "products": [ "species_350966" ], "modifiers": [], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS" ] }, "reaction_10431303": { "compartment": "compartment_5460", "id": "reaction_10431303", "reactome": "R-DME-73920", "name": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_73911" ], "products": [ "species_113529", "species_73909", "species_29362" ], "modifiers": [ [ "species_10431288", "catalyst" ] ], "additional_components": [ "Q7K3N4", "FBgn0033679" ] }, "reaction_10431475": { "compartment": "compartment_5460", "id": "reaction_10431475", "reactome": "R-DME-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_73909" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10431472", "catalyst" ] ], "additional_components": [ "Q9W058", "FBgn0035298" ] }, "reaction_10449897": { "compartment": "compartment_70101", "id": "reaction_10449897", "reactome": "R-DME-443439", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446844", "species_10447582" ], "products": [ "species_10449895" ], "modifiers": [], "additional_components": [ "FBgn0262733", "P00528", "FBgn0262733", "P11346", "Raf" ] }, "reaction_10449912": { "compartment": "compartment_70101", "id": "reaction_10449912", "reactome": "R-DME-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432006", "species_10446844" ], "products": [ "species_10449910" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P11346", "Raf", "P29310", "14-3-3zeta" ] }, "reaction_10433182": { "compartment": "compartment_5460", "id": "reaction_10433182", "reactome": "R-DME-77299", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77281" ], "products": [ "species_77284", "species_31649" ], "modifiers": [ [ "species_10433179", "catalyst" ] ], "additional_components": [ "A1ZBJ2", "FBgn0034432" ] }, "reaction_10433188": { "compartment": "compartment_5460", "id": "reaction_10433188", "reactome": "R-DME-77304", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77302" ], "products": [ "species_77272", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433186": { "compartment": "compartment_5460", "id": "reaction_10433186", "reactome": "R-DME-77303", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77300" ], "products": [ "species_113529", "species_77302", "species_29362" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433184": { "compartment": "compartment_5460", "id": "reaction_10433184", "reactome": "R-DME-77301", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77284", "species_113521" ], "products": [ "species_77300" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10427815": { "compartment": "compartment_7660", "id": "reaction_10427815", "reactome": "R-DME-69685", "name": "CHEK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427808", "species_29358" ], "products": [ "species_113582", "species_10427813" ], "modifiers": [ [ "species_10427797", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0019686" ] }, "reaction_10474328": { "compartment": "compartment_7660", "id": "reaction_10474328", "reactome": "R-DME-5628871", "name": "BRD7 promotes EP300-mediated acetylation of TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467732", "species_113560" ], "products": [ "species_2485002", "species_10474325" ], "modifiers": [ [ "species_10467732", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947", "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947", "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947" ] }, "reaction_10467734": { "compartment": "compartment_7660", "id": "reaction_10467734", "reactome": "R-DME-3222093", "name": "BRD7 binds TP53 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467730", "species_10427813", "species_10458126" ], "products": [ "species_10467732" ], "modifiers": [], "additional_components": [ "FBgn0031947", "Q8IMZ4", "FBgn0039044", "FBgn0261617", "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947" ] }, "reaction_10486189": { "compartment": "compartment_7660", "id": "reaction_10486189", "reactome": "R-DME-6805650", "name": "MTA2-NuRD complex deacetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10486149" ], "products": [ "species_10486151", "species_5566518" ], "modifiers": [ [ "species_10486186", "catalyst" ] ], "additional_components": [ "Q94517", "HDAC1", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q24572", "FBgn0263979" ] }, "reaction_10491585": { "compartment": "compartment_7660", "id": "reaction_10491585", "reactome": "R-DME-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491571" ], "products": [ "species_113582", "species_10491582" ], "modifiers": [ [ "species_10450891", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924", "Q8SXX1", "FBgn0039924", "FBgn0261524" ] }, "reaction_10487140": { "compartment": "compartment_7660", "id": "reaction_10487140", "reactome": "R-DME-6811508", "name": "ING2-bound EP300 acetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487130", "species_113560" ], "products": [ "species_2485002", "species_10487137" ], "modifiers": [ [ "species_10487130", "catalyst" ], [ "species_6810408", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044", "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044", "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10491589": { "compartment": "compartment_7660", "id": "reaction_10491589", "reactome": "R-DME-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491582", "species_10455258" ], "products": [ "species_10491587" ], "modifiers": [], "additional_components": [ "Q8SXX1", "FBgn0039924", "FBgn0015379", "P54353", "FBgn0015379", "Q8SXX1", "FBgn0039924" ] }, "reaction_10486887": { "compartment": "compartment_7660", "id": "reaction_10486887", "reactome": "R-DME-6810376", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_10469624" ], "products": [ "species_10486885" ], "modifiers": [], "additional_components": [ "FBgn0038546", "Q9VEF5", "FBgn0038546", "species_1806212" ] }, "reaction_10487132": { "compartment": "compartment_7660", "id": "reaction_10487132", "reactome": "R-DME-6811479", "name": "ING2 recruits EP300 to TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10469624", "species_10458126" ], "products": [ "species_10487130" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0038546", "FBgn0261617", "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10454653": { "compartment": "compartment_70101", "id": "reaction_10454653", "reactome": "R-DME-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446818", "species_113592" ], "products": [ "species_10454640", "species_29370" ], "modifiers": [ [ "species_10454650", "catalyst" ] ], "additional_components": [ "FBgn0264895", "FBgn0264895", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "Q03042", "FBgn0000442" ] }, "reaction_10446840": { "compartment": "compartment_70101", "id": "reaction_10446840", "reactome": "R-DME-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10446030" ], "products": [ "species_10446032" ], "modifiers": [], "additional_components": [ "FBgn0085421", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10446823": { "compartment": "compartment_70101", "id": "reaction_10446823", "reactome": "R-DME-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444262" ], "products": [ "species_111294", "species_10444300" ], "modifiers": [ [ "species_10446816", "catalyst" ], [ "species_10446821", "inhibitor" ] ], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "P08645", "FBgn0004636", "species_29420", "FBgn0264895", "P29310", "14-3-3zeta", "A8DYW8", "FBgn0264895" ] }, "reaction_10454642": { "compartment": "compartment_70101", "id": "reaction_10454642", "reactome": "R-DME-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446818", "species_10432008" ], "products": [ "species_10446821" ], "modifiers": [ [ "species_10454640", "inhibitor" ] ], "additional_components": [ "FBgn0264895", "P29310", "14-3-3zeta", "A8DYW8", "FBgn0264895", "FBgn0264895" ] }, "reaction_10446848": { "compartment": "compartment_70101", "id": "reaction_10446848", "reactome": "R-DME-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444262", "species_10446844" ], "products": [ "species_10446846" ], "modifiers": [], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "P08645", "FBgn0004636", "species_29438" ] }, "reaction_10433100": { "compartment": "compartment_7660", "id": "reaction_10433100", "reactome": "R-DME-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10433097" ], "products": [ "species_113582", "species_10433093" ], "modifiers": [ [ "species_10433097", "catalyst" ] ], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10434824": { "compartment": "compartment_7660", "id": "reaction_10434824", "reactome": "R-DME-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433097" ], "products": [ "species_10433097" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10472491": { "compartment": "compartment_5460", "id": "reaction_10472491", "reactome": "R-DME-5419261", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472480", "species_10472487" ], "products": [ "species_10472489" ], "modifiers": [], "additional_components": [ "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VM33", "FBgn0263133", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VM33", "FBgn0263133" ] }, "reaction_10472506": { "compartment": "compartment_5460", "id": "reaction_10472506", "reactome": "R-DME-5419264", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472502", "species_113573", "species_10472493" ], "products": [ "species_10472504" ], "modifiers": [], "additional_components": [ "Q9VKU3", "FBgn0032261", "Q9VK20", "FBgn0032486", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VK20", "FBgn0032486" ] }, "reaction_10472535": { "compartment": "compartment_5460", "id": "reaction_10472535", "reactome": "R-DME-5419281", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472524", "species_10472510" ], "products": [ "species_10472533" ], "modifiers": [], "additional_components": [ "FBgn0035980", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "Q9VSW4", "FBgn0035980", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555" ] }, "reaction_10472531": { "compartment": "compartment_5460", "id": "reaction_10472531", "reactome": "R-DME-5419273", "name": "Hydrolysis of GTP and dissociation of 28S and 39S subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472526" ], "products": [ "species_10472528", "species_113548", "species_10472216", "species_10472474", "species_10472524" ], "modifiers": [ [ "species_10472526", "catalyst" ] ], "additional_components": [ "Q9VSW4", "FBgn0035980", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472504" ], "products": [ "species_113548", "species_10472502", "species_5419287", "species_113525", "species_10472510" ], "modifiers": [], "additional_components": [ "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VK20", "FBgn0032486", "Q9VKU3", "FBgn0032261", "Q9VK20", "FBgn0032486", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555" ] }, "reaction_10497334": { "compartment": "compartment_17947", "id": "reaction_10497334", "reactome": "R-DME-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497318" ], "products": [ "species_10446324", "species_10497332", "species_10446302" ], "modifiers": [], "additional_components": [ "Q9VUL8", "FBgn0036484", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407", "FBgn0032407", "Q9VZD9", "FBgn0052250", "Q9VL02", "FBgn0005322", "B7YZT2", "FBgn0039969", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q7JZE1", "FBgn0034058", "Q7JRD4", "FBgn0033812", "Q7JUN3", "FBgn0039890", "Q9VPB8", "FBgn0037020", "Q9VQI6", "FBgn0031478", "FBgn0036484" ] }, "reaction_10497336": { "compartment": "compartment_17947", "id": "reaction_10497336", "reactome": "R-DME-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497316", "species_10446302" ], "products": [ "species_10497318" ], "modifiers": [], "additional_components": [ "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407", "FBgn0036484", "Q9VUL8", "FBgn0036484", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407" ] }, "reaction_10497338": { "compartment": "compartment_70101", "id": "reaction_10497338", "reactome": "R-DME-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446324", "species_10497314" ], "products": [ "species_10497316" ], "modifiers": [], "additional_components": [ "FBgn0032407", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407" ] }, "reaction_10497233": { "compartment": "compartment_70101", "id": "reaction_10497233", "reactome": "R-DME-9033509", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454130", "species_10497208" ], "products": [ "species_10497210" ], "modifiers": [], "additional_components": [ "FBgn0005632", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P55824", "FBgn0005632" ] }, "reaction_10497248": { "compartment": "compartment_17951", "id": "reaction_10497248", "reactome": "R-DME-9033520", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_10497187" ], "products": [ "species_10497245", "species_10497243" ], "modifiers": [ [ "species_10497187", "catalyst" ] ], "additional_components": [ "FBgn0035065", "FBgn0035065", "FBgn0035065", "FBgn0035065" ] }, "reaction_10497250": { "compartment": "compartment_17947", "id": "reaction_10497250", "reactome": "R-DME-9033527", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497197", "species_10495029" ], "products": [ "species_10497199" ], "modifiers": [], "additional_components": [ "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497204": { "compartment": "compartment_17947", "id": "reaction_10497204", "reactome": "R-DME-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497199" ], "products": [ "species_10427563", "species_10497201" ], "modifiers": [ [ "species_10497199", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497191": { "compartment": "compartment_17947", "id": "reaction_10497191", "reactome": "R-DME-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497173" ], "products": [ "species_10497189", "species_10495027" ], "modifiers": [], "additional_components": [ "Q7KML2", "FBgn0027572", "Q9VRJ4", "FBgn0035588", "Q27571", "FBgn0011676", "Q7JZB1", "FBgn0033543", "Q9VM80", "FBgn0031860", "Q9V492", "FBgn0039930", "A1Z8D3", "FBgn0061356", "Q9W2G8", "FBgn0034629", "Q9W2G9", "FBgn0034628", "Q9W3U0", "FBgn0029924", "Q9W106", "FBgn0035065", "B7Z028", "FBgn0031813", "B7Z0E0", "FBgn0001248", "Q9VXJ0", "FBgn0030731", "Q8SXR7", "FBgn0034999", "E1JHE4", "FBgn0267828", "Q7KVJ6", "FBgn0265187", "Q9W5W8", "FBgn0031092", "Q9W3Z3", "FBgn0014031", "Q7K3B7", "FBgn0034488", "Q9VHN8", "FBgn0037606", "Q9VIK0", "FBgn0032881", "Q9VM58", "FBgn0031877", "Q9VEM4", "FBgn0038486", "Q9VB02", "FBgn0039543", "P22817", "FBgn0001247", "P17336", "FBgn0000261", "Q9VIV6", "FBgn0032790", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VIV6", "FBgn0032790", "Q9V492", "FBgn0039930", "Q9VXJ0", "FBgn0030731", "Q9W106", "FBgn0035065", "B7Z0E0", "FBgn0001248", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999", "A1Z8D3", "FBgn0061356", "Q9VM80", "FBgn0031860", "Q7JZB1", "FBgn0033543", "Q9VHN8", "FBgn0037606", "Q9W5W8", "FBgn0031092", "Q9VEM4", "FBgn0038486", "Q9VIK0", "FBgn0032881", "Q9W3Z3", "FBgn0014031", "Q9VM58", "FBgn0031877", "P22817", "FBgn0001247", "Q7K3B7", "FBgn0034488", "P17336", "FBgn0000261", "B7Z028", "FBgn0031813", "Q9VRJ4", "FBgn0035588", "Q9VB02", "FBgn0039543", "Q27571", "FBgn0011676", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497193": { "compartment": "compartment_17947", "id": "reaction_10497193", "reactome": "R-DME-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497171", "species_10497169" ], "products": [ "species_10497173" ], "modifiers": [], "additional_components": [ "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q7KML2", "FBgn0027572", "Q9VRJ4", "FBgn0035588", "Q27571", "FBgn0011676", "Q7JZB1", "FBgn0033543", "Q9VM80", "FBgn0031860", "Q9V492", "FBgn0039930", "A1Z8D3", "FBgn0061356", "Q9W2G8", "FBgn0034629", "Q9W2G9", "FBgn0034628", "Q9W3U0", "FBgn0029924", "Q9W106", "FBgn0035065", "B7Z028", "FBgn0031813", "B7Z0E0", "FBgn0001248", "Q9VXJ0", "FBgn0030731", "Q8SXR7", "FBgn0034999", "E1JHE4", "FBgn0267828", "Q7KVJ6", "FBgn0265187", "Q9W5W8", "FBgn0031092", "Q9W3Z3", "FBgn0014031", "Q7K3B7", "FBgn0034488", "Q9VHN8", "FBgn0037606", "Q9VIK0", "FBgn0032881", "Q9VM58", "FBgn0031877", "Q9VEM4", "FBgn0038486", "Q9VB02", "FBgn0039543", "P22817", "FBgn0001247", "P17336", "FBgn0000261", "Q9VIV6", "FBgn0032790", "O46085", "FBgn0023516", "Q7KML2", "FBgn0027572", "Q9VRJ4", "FBgn0035588", "Q27571", "FBgn0011676", "Q7JZB1", "FBgn0033543", "Q9VM80", "FBgn0031860", "Q9V492", "FBgn0039930", "A1Z8D3", "FBgn0061356", "Q9W2G8", "FBgn0034629", "Q9W2G9", "FBgn0034628", "Q9W3U0", "FBgn0029924", "Q9W106", "FBgn0035065", "B7Z028", "FBgn0031813", "B7Z0E0", "FBgn0001248", "Q9VXJ0", "FBgn0030731", "Q8SXR7", "FBgn0034999", "E1JHE4", "FBgn0267828", "Q7KVJ6", "FBgn0265187", "Q9W5W8", "FBgn0031092", "Q9W3Z3", "FBgn0014031", "Q7K3B7", "FBgn0034488", "Q9VHN8", "FBgn0037606", "Q9VIK0", "FBgn0032881", "Q9VM58", "FBgn0031877", "Q9VEM4", "FBgn0038486", "Q9VB02", "FBgn0039543", "P22817", "FBgn0001247", "P17336", "FBgn0000261", "Q9VIV6", "FBgn0032790", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497241": { "compartment": "compartment_17947", "id": "reaction_10497241", "reactome": "R-DME-9033514", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497237" ], "products": [ "species_10497197", "species_10497239" ], "modifiers": [], "additional_components": [ "Q9VSN7", "FBgn0035922", "Q9V778", "FBgn0033983", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "FBgn0033983" ] }, "reaction_10497213": { "compartment": "compartment_70101", "id": "reaction_10497213", "reactome": "R-DME-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10497210" ], "products": [ "species_10497167", "species_10454130", "species_10426987" ], "modifiers": [ [ "species_10497210", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P55824", "FBgn0005632", "FBgn0023516", "FBgn0005632", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P55824", "FBgn0005632" ] }, "reaction_10497087": { "compartment": "compartment_70101", "id": "reaction_10497087", "reactome": "R-DME-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497083", "species_10497078" ], "products": [ "species_10497085" ], "modifiers": [], "additional_components": [ "FBgn0033983", "FBgn0035922", "Q9VSN7", "FBgn0035922", "Q9V778", "FBgn0033983" ] }, "reaction_10497622": { "compartment": "compartment_70101", "id": "reaction_10497622", "reactome": "R-DME-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497405", "species_10497618" ], "products": [ "species_10497620" ], "modifiers": [], "additional_components": [ "Q9VJD4", "FBgn0032640", "P14599", "FBgn0000108", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P14599", "FBgn0000108", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9VJD4", "FBgn0032640" ] }, "reaction_10497453": { "compartment": "compartment_70101", "id": "reaction_10497453", "reactome": "R-DME-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497405", "species_10497449" ], "products": [ "species_10497451" ], "modifiers": [], "additional_components": [ "Q9VJD4", "FBgn0032640", "Q24509", "FBgn0011708", "Q7JZN0", "FBgn0010638", "Q9V4N3", "FBgn0264294", "Q9VJC0", "FBgn0032652", "Q9VUZ3", "FBgn0036575", "Q8IRR0", "FBgn0029854", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9VWE9", "FBgn0031049", "Q9VGJ9", "FBgn0037933", "Q8SYY6", "FBgn0047135", "Q9VEJ4", "FBgn0038515", "B7Z0E5", "FBgn0266757", "Q24547", "FBgn0013343", "Q24509", "FBgn0011708", "Q7JZN0", "FBgn0010638", "Q9V4N3", "FBgn0264294", "Q9VJC0", "FBgn0032652", "Q9VUZ3", "FBgn0036575", "Q8IRR0", "FBgn0029854", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9VWE9", "FBgn0031049", "Q9VGJ9", "FBgn0037933", "Q8SYY6", "FBgn0047135", "Q9VEJ4", "FBgn0038515", "B7Z0E5", "FBgn0266757", "Q24547", "FBgn0013343", "Q9VJD4", "FBgn0032640" ] }, "reaction_10495803": { "compartment": "compartment_5460", "id": "reaction_10495803", "reactome": "R-DME-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495795" ], "products": [], "modifiers": [ [ "species_10495800", "catalyst" ] ], "additional_components": [ "Q9W3X7", "FBgn0029888", "FBgn0033005" ] }, "reaction_10462211": { "compartment": "compartment_70616", "id": "reaction_10462211", "reactome": "R-DME-1955380", "name": "TIMM9:TIMM10 transfers proteins to TIMM22", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462198", "species_10462173", "species_10462205" ], "products": [ "species_10462209" ], "modifiers": [], "additional_components": [ "Q26365", "FBgn0003360", "Q9W2D6", "FBgn0027360", "Q9VYD7", "FBgn0030480", "FBgn0051229", "FBgn0027358", "Q9Y0V3", "FBgn0027358", "Q9W2D6", "FBgn0027360", "Q9VYD7", "FBgn0030480", "Q8IN78", "FBgn0051229", "Q26365", "FBgn0003360" ] }, "reaction_10471823": { "compartment": "compartment_70101", "id": "reaction_10471823", "reactome": "R-DME-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10471803" ], "products": [ "species_353106", "species_10471790" ], "modifiers": [ [ "species_10471820", "catalyst" ] ], "additional_components": [ "FBgn0000559", "FBgn0000559", "Q9VGQ9", "FBgn0037883", "Q9VFE9", "FBgn0038272", "Q9VTM2", "FBgn0036194" ] }, "reaction_10471787": { "compartment": "compartment_70101", "id": "reaction_10471787", "reactome": "R-DME-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471779", "species_113592", "species_31633" ], "products": [ "species_111294", "species_10435612", "species_76577" ], "modifiers": [ [ "species_10471784", "catalyst" ] ], "additional_components": [ "FBgn0000559", "FBgn0000559", "FBgn0030336" ] }, "reaction_10471801": { "compartment": "compartment_70101", "id": "reaction_10471801", "reactome": "R-DME-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10471790" ], "products": [ "species_10471793", "species_71285" ], "modifiers": [ [ "species_10471798", "catalyst" ] ], "additional_components": [ "FBgn0000559", "FBgn0000559", "FBgn0024558" ] }, "reaction_10479423": { "compartment": "compartment_70101", "id": "reaction_10479423", "reactome": "R-DME-6782628", "name": "USP8 deubiquitinates STAM2:HGS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479418" ], "products": [ "species_10426987", "species_10479420" ], "modifiers": [ [ "species_10479418", "catalyst" ] ], "additional_components": [ "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VDD8", "FBgn0038862", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VDD8", "FBgn0038862", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VDD8", "FBgn0038862" ] }, "reaction_10479326": { "compartment": "compartment_70101", "id": "reaction_10479326", "reactome": "R-DME-6781899", "name": "USP13 binds SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479271", "species_10444782" ], "products": [ "species_10479324" ], "modifiers": [], "additional_components": [ "FBgn0035402", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q9VZU7", "FBgn0035402" ] }, "reaction_10477596": { "compartment": "compartment_7660", "id": "reaction_10477596", "reactome": "R-DME-5690080", "name": "USP3,SAGA deubiquitinate Histone H2A,H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477591" ], "products": [ "species_10427430", "species_10477593" ], "modifiers": [ [ "species_10477591", "catalyst" ] ], "additional_components": [ "Q27272", "FBgn0000617", "M9PHZ1", "FBgn0030891", "Q9XZT7", "FBgn0026324", "Q8I8V0", "FBgn0037555", "Q9VVR1", "FBgn0013717", "Q9VTZ1", "FBgn0020388", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q27272", "FBgn0000617", "M9PHZ1", "FBgn0030891", "Q9XZT7", "FBgn0026324", "Q8I8V0", "FBgn0037555", "Q9VVR1", "FBgn0013717", "Q9VTZ1", "FBgn0020388", "Q27272", "FBgn0000617", "M9PHZ1", "FBgn0030891", "Q9XZT7", "FBgn0026324", "Q8I8V0", "FBgn0037555", "Q9VVR1", "FBgn0013717", "Q9VTZ1", "FBgn0020388" ] }, "reaction_10477625": { "compartment": "compartment_70101", "id": "reaction_10477625", "reactome": "R-DME-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477618", "species_29356" ], "products": [ "species_10477620", "species_10477101" ], "modifiers": [ [ "species_10477618", "catalyst" ] ], "additional_components": [ "Q8IQ27", "FBgn0031187", "P83104", "FBgn0046689", "Q8IQ27", "FBgn0031187", "P83104", "FBgn0046689", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8IQ27", "FBgn0031187", "P83104", "FBgn0046689" ] }, "reaction_10477496": { "compartment": "compartment_7660", "id": "reaction_10477496", "reactome": "R-DME-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477261" ], "products": [ "species_10477267", "species_10477493" ], "modifiers": [ [ "species_10477261", "catalyst" ] ], "additional_components": [ "Q7KMQ6", "Pten", "Q95V55", "foxo", "Q8IMZ4", "FBgn0039044", "Q9VYQ8", "FBgn0030366", "Q7KMQ6", "Pten", "Q95V55", "foxo", "Q8IMZ4", "FBgn0039044", "Q9VYQ8", "FBgn0030366", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q7KMQ6", "Pten", "Q95V55", "foxo", "Q8IMZ4", "FBgn0039044", "Q9VYQ8", "FBgn0030366" ] }, "reaction_10477112": { "compartment": "compartment_70101", "id": "reaction_10477112", "reactome": "R-DME-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477108", "species_10475480" ], "products": [ "species_10477110" ], "modifiers": [], "additional_components": [ "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q9VKZ8", "Usp14" ] }, "reaction_10479189": { "compartment": "compartment_70101", "id": "reaction_10479189", "reactome": "R-DME-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479180" ], "products": [ "species_10479186", "species_10477101" ], "modifiers": [ [ "species_10479180", "catalyst" ] ], "additional_components": [ "Q9VRP5", "FBgn0260936", "Q9U1H8", "FBgn0029121", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q9VRP5", "FBgn0260936", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q9U1H8", "FBgn0029121", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRP5", "FBgn0260936", "Q9U1H8", "FBgn0029121", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10479220": { "compartment": "compartment_70101", "id": "reaction_10479220", "reactome": "R-DME-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479215" ], "products": [ "species_10479217", "species_10437507" ], "modifiers": [ [ "species_10479215", "catalyst" ] ], "additional_components": [ "P83104", "FBgn0046689", "Q9W3I9", "FBgn0265464", "Q8IPC5", "FBgn0032210", "P83104", "FBgn0046689", "Q9W3I9", "FBgn0265464", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P83104", "FBgn0046689", "Q9W3I9", "FBgn0265464", "Q8IPC5", "FBgn0032210" ] }, "reaction_10479281": { "compartment": "compartment_70101", "id": "reaction_10479281", "reactome": "R-DME-6781779", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479276" ], "products": [ "species_10437507", "species_10479278" ], "modifiers": [ [ "species_10479276", "catalyst" ] ], "additional_components": [ "Q9VCE1", "FBgn0264325", "Q9VZU7", "FBgn0035402", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402", "Q9VCE1", "FBgn0264325", "Q9VCE1", "FBgn0264325", "Q9VZU7", "FBgn0035402" ] }, "reaction_10477646": { "compartment": "compartment_70101", "id": "reaction_10477646", "reactome": "R-DME-5690196", "name": "USP8 deubiquitinates RNF128", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477637" ], "products": [ "species_10454480", "species_10477643" ], "modifiers": [ [ "species_10477637", "catalyst" ] ], "additional_components": [ "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q9VDD8", "FBgn0038862", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q9VDD8", "FBgn0038862", "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q9VDD8", "FBgn0038862" ] }, "reaction_10479438": { "compartment": "compartment_7660", "id": "reaction_10479438", "reactome": "R-DME-6782820", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479431" ], "products": [ "species_10477395", "species_10479435" ], "modifiers": [ [ "species_10479431", "catalyst" ] ], "additional_components": [ "Q9VRP5", "FBgn0260936", "Q9VWG2", "FBgn0031036", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9VRP5", "FBgn0260936", "Q9VWG2", "FBgn0031036", "Q9VRP5", "FBgn0260936", "Q9VWG2", "FBgn0031036" ] }, "reaction_10477515": { "compartment": "compartment_7660", "id": "reaction_10477515", "reactome": "R-DME-5689973", "name": "USP10,USP24,USP42 deubiquitinate TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477510" ], "products": [ "species_10477493", "species_10477512" ], "modifiers": [ [ "species_10477510", "catalyst" ] ], "additional_components": [ "Q7JQI1", "FBgn0033738", "Q9VRP5", "FBgn0260936", "Q8IMZ4", "FBgn0039044", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q7JQI1", "FBgn0033738", "Q9VRP5", "FBgn0260936", "Q8IMZ4", "FBgn0039044", "Q7JQI1", "FBgn0033738", "Q9VRP5", "FBgn0260936", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10479211": { "compartment": "compartment_7660", "id": "reaction_10479211", "reactome": "R-DME-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479206" ], "products": [ "species_10477493", "species_10479208" ], "modifiers": [ [ "species_10479206", "catalyst" ] ], "additional_components": [ "Q8WS79", "FBgn0035849", "Q9VBC4", "FBgn0039451", "Q9VCT9", "FBgn0039025", "Q1LZ08", "FBgn0033607", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q8WS79", "FBgn0035849", "Q9VBC4", "FBgn0039451", "Q9VCT9", "FBgn0039025", "Q1LZ08", "FBgn0033607", "Q8WS79", "FBgn0035849", "Q9VBC4", "FBgn0039451", "Q9VCT9", "FBgn0039025", "Q1LZ08", "FBgn0033607" ] }, "reaction_10477608": { "compartment": "compartment_70101", "id": "reaction_10477608", "reactome": "R-DME-5690152", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477603" ], "products": [ "species_10477605", "species_10426987" ], "modifiers": [ [ "species_10477603", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402" ] }, "reaction_10479269": { "compartment": "compartment_7660", "id": "reaction_10479269", "reactome": "R-DME-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479262" ], "products": [ "species_10479266", "species_10477493" ], "modifiers": [ [ "species_10479262", "catalyst" ] ], "additional_components": [ "O18413", "Rpt6", "Q9VH07", "FBgn0040078", "P14785", "FBgn0000404", "Q9VZP3", "FBgn0010317", "O18413", "Rpt6", "Q9VH07", "FBgn0040078", "P14785", "FBgn0000404", "Q9VZP3", "FBgn0010317", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "O18413", "Rpt6", "Q9VH07", "FBgn0040078", "P14785", "FBgn0000404", "Q9VZP3", "FBgn0010317" ] }, "reaction_10479459": { "compartment": "compartment_7660", "id": "reaction_10479459", "reactome": "R-DME-6783177", "name": "USP21 deubiquitinates GATA3,IL33", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479454" ], "products": [ "species_10479456", "species_10477493" ], "modifiers": [ [ "species_10479454", "catalyst" ] ], "additional_components": [ "Q9VKZ0", "FBgn0032223", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q8IQ27", "FBgn0031187", "Q8IQ27", "FBgn0031187", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9VKZ0", "FBgn0032223", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q8IQ27", "FBgn0031187" ] }, "reaction_10479557": { "compartment": "compartment_70101", "id": "reaction_10479557", "reactome": "R-DME-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718" ], "products": [ "species_10457720" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10479555": { "compartment": "compartment_70101", "id": "reaction_10479555", "reactome": "R-DME-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457720" ], "products": [ "species_10457732" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10454317": { "compartment": "compartment_5460", "id": "reaction_10454317", "reactome": "R-DME-888548", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_880046", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113536" ], "modifiers": [ [ "species_10454314", "catalyst" ] ], "additional_components": [ "Q9VBP6", "FBgn0039349" ] }, "reaction_10454932": { "compartment": "compartment_5460", "id": "reaction_10454932", "reactome": "R-DME-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_916850", "species_113594" ], "products": [ "species_880046", "species_113552" ], "modifiers": [ [ "species_10454929", "catalyst" ] ], "additional_components": [ "Q9VW68", "FBgn0036927", "CHEBI:33739" ] }, "reaction_10457567": { "compartment": "compartment_7660", "id": "reaction_10457567", "reactome": "R-DME-997263", "name": "JMJD1C demethylates H3K9 mono- and di-methylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457547" ], "products": [ "species_10457559" ], "modifiers": [ [ "species_10457564", "catalyst" ] ], "additional_components": [ "P02299", "FBgn0001199", "C0HL67", "FBgn0004828", "C0HL66", "FBgn0014857", "P02299", "FBgn0001199", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "FBgn0037703" ] }, "reaction_10457532": { "compartment": "compartment_7660", "id": "reaction_10457532", "reactome": "R-DME-996755", "name": "ZFPM proteins bind GATA proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457477", "species_10457528" ], "products": [ "species_10457530" ], "modifiers": [], "additional_components": [ "FBgn0003963", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "P52168", "FBgn0003117", "Q9VF00", "FBgn0038391", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "P52168", "FBgn0003117", "Q9VF00", "FBgn0038391", "Q9VPQ6", "FBgn0003963" ] }, "reaction_10457401": { "compartment": "compartment_70101", "id": "reaction_10457401", "reactome": "R-DME-992708", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434305", "species_10457397" ], "products": [ "species_10457399" ], "modifiers": [], "additional_components": [ "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "Q7KVW1", "FBgn0263987", "Q9V3I3", "FBgn0040079", "Q7KVW1", "FBgn0263987", "Q9V3I3", "FBgn0040079", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243" ] }, "reaction_10457385": { "compartment": "compartment_17906", "id": "reaction_10457385", "reactome": "R-DME-992703", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457381" ], "products": [ "species_10457383" ], "modifiers": [], "additional_components": [ "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596" ] }, "reaction_10457432": { "compartment": "compartment_7660", "id": "reaction_10457432", "reactome": "R-DME-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457428", "species_10457406" ], "products": [ "species_10457430" ], "modifiers": [], "additional_components": [ "P02299", "FBgn0001199", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "FBgn0039019", "Q9VCU6", "FBgn0039019", "P02299", "FBgn0001199", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828" ] }, "reaction_10457637": { "compartment": "compartment_70101", "id": "reaction_10457637", "reactome": "R-DME-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457633", "species_10457631" ], "products": [ "species_10457635" ], "modifiers": [], "additional_components": [ "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "M9PCG3", "FBgn0260486", "Q9VPI9", "FBgn0031216", "M9PCG3", "FBgn0260486", "Q9VPI9", "FBgn0031216", "P40793", "FBgn0010341", "P40792", "RAC1_DROME" ] }, "reaction_10457604": { "compartment": "compartment_74700", "id": "reaction_10457604", "reactome": "R-DME-1011576", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457600", "species_10457591" ], "products": [ "species_10457602" ], "modifiers": [], "additional_components": [ "FBgn0261064", "FBgn0016693", "Q8T8W3", "FBgn0016693", "Q9VLS5", "FBgn0261064" ] }, "reaction_10457586": { "compartment": "compartment_5460", "id": "reaction_10457586", "reactome": "R-DME-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113581", "species_113525" ], "modifiers": [ [ "species_10457583", "catalyst" ] ], "additional_components": [ "FBgn0042094" ] }, "reaction_10454176": { "compartment": "compartment_70101", "id": "reaction_10454176", "reactome": "R-DME-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454167", "species_10454172" ], "products": [ "species_10454174" ], "modifiers": [], "additional_components": [ "FBgn0034577", "FBgn0011570", "P48603", "FBgn0011570", "Q9W2N0", "FBgn0034577" ] }, "reaction_10457472": { "compartment": "compartment_7660", "id": "reaction_10457472", "reactome": "R-DME-996727", "name": "REST recruits the BHC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457446", "species_10457468" ], "products": [ "species_10457470" ], "modifiers": [], "additional_components": [ "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q94517", "HDAC1", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397", "Q94517", "HDAC1", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397" ] }, "reaction_10457648": { "compartment": "compartment_74700", "id": "reaction_10457648", "reactome": "R-DME-1011600", "name": "Rabenosyn-5 connects Rab5 to VPS-45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457600", "species_10457639", "species_10457644" ], "products": [ "species_10457646" ], "modifiers": [], "additional_components": [ "FBgn0261064", "FBgn0014010", "FBgn0261049", "Q9VHB5", "FBgn0261049", "Q9V3I2", "FBgn0014010", "Q9VLS5", "FBgn0261064" ] }, "reaction_10480078": { "compartment": "compartment_1222282", "id": "reaction_10480078", "reactome": "R-DME-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10480037", "catalyst" ] ], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_10480042": { "compartment": "compartment_21994", "id": "reaction_10480042", "reactome": "R-DME-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10480039", "catalyst" ] ], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_10489081": { "compartment": "compartment_984", "id": "reaction_10489081", "reactome": "R-DME-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_8855492" ], "products": [ "species_109276", "species_8855489" ], "modifiers": [ [ "species_10489078", "catalyst" ] ], "additional_components": [ "Q9VZZ4", "FBgn0011828", "CHEBI:55376" ] }, "reaction_10491978": { "compartment": "compartment_1222282", "id": "reaction_10491978", "reactome": "R-DME-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_1470067", "species_6789221" ], "products": [ "species_8933637", "species_1222475" ], "modifiers": [ [ "species_10480037", "catalyst" ] ], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_10480080": { "compartment": "compartment_21994", "id": "reaction_10480080", "reactome": "R-DME-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480037", "species_983438" ], "products": [ "species_10480039" ], "modifiers": [], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828", "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_209075": { "compartment": "compartment_876", "id": "reaction_209075", "reactome": "R-DME-209075", "name": "Destabilisation and degradation of AXN in the 'destruction complex'", "reversible": "false", "notes": "Axin (AXN) is now destabilised and is degraded by an unknown mechanism, possibly by a similar ubiquitin-mediated proteolysis responsible for cytoplasmic Armadillo (ARM) degradation.", "reactants": [ "species_206993" ], "products": [ "species_206837" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P54367", "CkIalpha", "O76324", "DCO", "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_209120": { "compartment": "compartment_70101", "id": "reaction_209120", "reactome": "R-DME-209120", "name": "Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR", "reversible": "false", "notes": "Phosphorylated Arrow (ARR) is recognised by Axin (AXN) which binds to it along with the rest of the 'destruction complex'. Dishevelled (DSH) is recruited to the cytoplasmic part of Frizzled (FZ/FZ2) and additionally forms an interaction with AXN. There is conjecture whether DSH first binds to AXN, helping to recruit it to the membrane, while the 'destruction complex' is free in the cytoplasm.", "reactants": [ "species_207028", "species_205749", "species_206613" ], "products": [ "species_206952" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209081": { "compartment": "compartment_70101", "id": "reaction_209081", "reactome": "R-DME-209081", "name": "Disassembly of the destabilised 'destruction complex'", "reversible": "false", "notes": "The destabilised 'destruction complex' disassembles into the cytoplasm. The cytoplasmic concentration of Axin (AXN) has now decreased.", "reactants": [ "species_206837" ], "products": [ "species_206938", "species_205716", "species_206613", "species_205749", "species_206581", "species_205729", "species_206210" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC" ] }, "reaction_209112": { "compartment": "compartment_70101", "id": "reaction_209112", "reactome": "R-DME-209112", "name": "Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM", "reversible": "false", "notes": "The binding of Dishevelled (DSH) to Axin (AXN) in the 'destruction complex' appears to inhibit the kinase Shaggy (SGG). As this component appears to be the main instigator in keeping the 'destruction complex' phosphorylated, it's inactivation means the protein phosphatase orthologue, PP2A, can dephosphorylate members of the 'destruction complex'. This results in a decreased binding affinity for Armadillo (ARM) by AXN and APC (APC/APC2). The now unphosphorylated ARM disassociates from the 'destruction complex' into the cytoplasm.", "reactants": [ "species_206952" ], "products": [ "species_205774", "species_29372", "species_206993" ], "modifiers": [ [ "species_206612", "catalyst" ] ], "additional_components": [ "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P51140", "phospho-dsh", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_209297": { "compartment": "compartment_7660", "id": "reaction_209297", "reactome": "R-DME-209297", "name": "PYGO binds to the LGS:ARM complex", "reversible": "false", "notes": "The now nuclear Legless:Armadillo (LGS:ARM) complex binds to the nuclear anchor Pygopus (PYGO).", "reactants": [ "species_205990", "species_206839" ], "products": [ "species_206851" ], "modifiers": [], "additional_components": [ "Q961D9", "LGS", "P18824", "arm", "Q961D9", "LGS", "P18824", "arm", "Q9V9W8", "PYGO" ] }, "reaction_209181": { "compartment": "compartment_7660", "id": "reaction_209181", "reactome": "R-DME-209181", "name": "ARM displaces GRO and binds to PAN which activates transcription", "reversible": "false", "notes": "Armadillo (ARM) in its complex binds to Pangolin (PAN) and transcription is now activated.", "reactants": [ "species_206798", "species_206851" ], "products": [ "species_206729", "species_205750" ], "modifiers": [], "additional_components": [ "P91943", "PAN", "P16371", "GRO", "Q961D9", "LGS", "P18824", "arm", "Q9V9W8", "PYGO", "Q961D9", "LGS", "P18824", "arm", "Q9V9W8", "PYGO", "P91943", "PAN" ] }, "reaction_10428700": { "compartment": "compartment_70101", "id": "reaction_10428700", "reactome": "R-DME-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10428697", "catalyst" ] ], "additional_components": [ "Q9VKJ0", "FBgn0040211", "species_111793" ] }, "reaction_10428678": { "compartment": "compartment_70101", "id": "reaction_10428678", "reactome": "R-DME-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29506" ], "products": [ "species_29404", "species_31365" ], "modifiers": [ [ "species_10428675", "catalyst" ] ], "additional_components": [ "Q9VY42", "FBgn0030558" ] }, "reaction_10428710": { "compartment": "compartment_70101", "id": "reaction_10428710", "reactome": "R-DME-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10428707", "catalyst" ] ], "additional_components": [ "species_29450", "Q9VHD2", "FBgn0037697" ] }, "reaction_10428690": { "compartment": "compartment_70101", "id": "reaction_10428690", "reactome": "R-DME-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10428687", "catalyst" ] ], "additional_components": [ "species_351595", "Q9VPF3", "FBgn0036992", "species_111793" ] }, "reaction_10428720": { "compartment": "compartment_70101", "id": "reaction_10428720", "reactome": "R-DME-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29666", "species_29586" ], "modifiers": [ [ "species_10428717", "catalyst" ] ], "additional_components": [ "Q9VZI8", "FBgn0016013" ] }, "reaction_10479117": { "compartment": "compartment_70101", "id": "reaction_10479117", "reactome": "R-DME-5696365", "name": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696361", "species_29356" ], "products": [ "species_29502", "species_29448", "species_5359061" ], "modifiers": [ [ "species_10479114", "catalyst" ] ], "additional_components": [ "Q9VXT7", "FBgn0030653" ] }, "reaction_10454396": { "compartment": "compartment_70101", "id": "reaction_10454396", "reactome": "R-DME-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_29432", "species_893599" ], "modifiers": [ [ "species_10454393", "catalyst" ] ], "additional_components": [ "Q8SXC2", "FBgn0037955" ] }, "reaction_10428667": { "compartment": "compartment_70101", "id": "reaction_10428667", "reactome": "R-DME-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10428664", "catalyst" ] ], "additional_components": [ "O76454", "FBgn0024841" ] }, "reaction_10428647": { "compartment": "compartment_70101", "id": "reaction_10428647", "reactome": "R-DME-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29502", "species_29368" ], "products": [ "species_71112", "species_29506" ], "modifiers": [ [ "species_10428644", "catalyst" ] ], "additional_components": [ "species_111793", "P17276", "FBgn0001208" ] }, "reaction_10428657": { "compartment": "compartment_70101", "id": "reaction_10428657", "reactome": "R-DME-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71129", "species_73473" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10428654", "catalyst" ] ], "additional_components": [ "Q9VSU6", "FBgn0035964" ] }, "reaction_10426910": { "compartment": "compartment_7660", "id": "reaction_10426910", "reactome": "R-DME-68611", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426899", "species_10426906" ], "products": [ "species_10426908" ], "modifiers": [], "additional_components": [ "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181", "FBgn0286788", "O16810", "FBgn0286788", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181" ] }, "reaction_10426892": { "compartment": "compartment_7660", "id": "reaction_10426892", "reactome": "R-DME-68603", "name": "Orc5 associates with Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426881", "species_10426888" ], "products": [ "species_10426890" ], "modifiers": [], "additional_components": [ "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "FBgn0015271", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654" ] }, "reaction_10426919": { "compartment": "compartment_7660", "id": "reaction_10426919", "reactome": "R-DME-68615", "name": "Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426915", "species_10426908" ], "products": [ "species_10426917" ], "modifiers": [], "additional_components": [ "FBgn0023180", "O16810", "FBgn0286788", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181", "Q24168", "FBgn0015270", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181" ] }, "reaction_10426901": { "compartment": "compartment_7660", "id": "reaction_10426901", "reactome": "R-DME-68610", "name": "Orc4 associates with Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426897", "species_10426890" ], "products": [ "species_10426899" ], "modifiers": [], "additional_components": [ "FBgn0023181", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181" ] }, "reaction_10426883": { "compartment": "compartment_7660", "id": "reaction_10426883", "reactome": "R-DME-68595", "name": "Orc3 associates with Orc2 constitutively bound at origins of replication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426872", "species_10426879" ], "products": [ "species_10426881" ], "modifiers": [], "additional_components": [ "FBgn0005654", "Q24168", "FBgn0015270", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654" ] }, "reaction_10432475": { "compartment": "compartment_7660", "id": "reaction_10432475", "reactome": "R-DME-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432463" ], "products": [ "species_10432471" ], "modifiers": [], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10432473": { "compartment": "compartment_7660", "id": "reaction_10432473", "reactome": "R-DME-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432471" ], "products": [ "species_10431434", "species_113541" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10432465": { "compartment": "compartment_7660", "id": "reaction_10432465", "reactome": "R-DME-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432459", "species_30595" ], "products": [ "species_10432463" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10437548": { "compartment": "compartment_5460", "id": "reaction_10437548", "reactome": "R-DME-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10437537" ], "products": [ "species_76633", "species_10437535" ], "modifiers": [ [ "species_10437545", "catalyst" ] ], "additional_components": [ "species_31649", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "species_113596", "FBgn0286783" ] }, "reaction_10436779": { "compartment": "compartment_70616", "id": "reaction_10436779", "reactome": "R-DME-164651", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10436150", "species_113529", "species_76633" ], "products": [ "species_73663", "species_10436148", "species_76633", "species_163953" ], "modifiers": [ [ "species_10436776", "catalyst" ] ], "additional_components": [ "CHEBI:38574", "P84029", "FBgn0284248", "CHEBI:38573", "P84029", "FBgn0284248", "Q9VRL0", "FBgn0035600", "Q9VFF0", "FBgn0038271", "Q9VXI6", "FBgn0030733", "Q9VQ29", "FBgn0021906", "Q9VVH5", "FBgn0036728", "A8Y535", "FBgn0260008", "P18935", "FBgn0013678", "Q9XY35", "FBgn0011227", "Q9VV75", "FBgn0250814" ] }, "reaction_10437540": { "compartment": "compartment_5460", "id": "reaction_10437540", "reactome": "R-DME-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31649", "species_10437535" ], "products": [ "species_10437537", "species_113596" ], "modifiers": [ [ "species_10437535", "catalyst" ] ], "additional_components": [ "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "species_113596", "species_31649", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "species_113596" ] }, "reaction_10436576": { "compartment": "compartment_70616", "id": "reaction_10436576", "reactome": "R-DME-163217", "name": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_113529", "species_29362" ], "products": [ "species_76633", "species_113526", "species_163953" ], "modifiers": [ [ "species_10436566", "catalyst" ], [ "species_10436572", "catalyst" ] ], "additional_components": [ "Q9VMU0", "FBgn0031684", "Q9VMI3", "FBgn0031771", "species_76629", "Q9VWI0", "FBgn0031021", "Q94511", "FBgn0017566", "Q9VQD7", "FBgn0031436", "Q9VX36", "FBgn0030853", "P18931", "FBgn0262952", "P18932", "FBgn0013684", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "P18929", "FBgn0013679", "FBgn0033086" ] }, "reaction_10440271": { "compartment": "compartment_70101", "id": "reaction_10440271", "reactome": "R-DME-193073", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176626", "species_29360" ], "products": [ "species_70106", "species_193079", "species_73473" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10440269": { "compartment": "compartment_70101", "id": "reaction_10440269", "reactome": "R-DME-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193079", "species_29364" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10440264", "catalyst" ] ], "additional_components": [ "FBgn0029975" ] }, "reaction_10498692": { "compartment": "compartment_70101", "id": "reaction_10498692", "reactome": "R-DME-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10469802", "catalyst" ] ], "additional_components": [ "FBgn0032014" ] }, "reaction_10443612": { "compartment": "compartment_876", "id": "reaction_10443612", "reactome": "R-DME-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443603", "species_10443588", "species_10443573", "species_10443608", "species_10443593", "species_10443578", "species_10443598", "species_10443583" ], "products": [ "species_10443610" ], "modifiers": [], "additional_components": [ "FBgn0266671", "FBgn0266674", "FBgn0266672", "FBgn0266667", "FBgn0266668", "FBgn0266670", "FBgn0266669", "FBgn0266673", "Q9XTM1", "FBgn0266673", "Q9VVG4", "FBgn0266669", "Q9VQQ9", "FBgn0266670", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VNH6", "FBgn0266672", "Q9VDE6", "FBgn0266674", "Q9V8K2", "FBgn0266671" ] }, "reaction_10490116": { "compartment": "compartment_70101", "id": "reaction_10490116", "reactome": "R-DME-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10490113", "catalyst" ] ], "additional_components": [ "FBgn0033463" ] }, "reaction_10490199": { "compartment": "compartment_70101", "id": "reaction_10490199", "reactome": "R-DME-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_8868393", "species_1806234" ], "modifiers": [ [ "species_10448907", "catalyst" ] ], "additional_components": [ "FBgn0020626" ] }, "reaction_10440382": { "compartment": "compartment_70101", "id": "reaction_10440382", "reactome": "R-DME-193766", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10440366": { "compartment": "compartment_70101", "id": "reaction_10440366", "reactome": "R-DME-193711", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10440380": { "compartment": "compartment_17951", "id": "reaction_10440380", "reactome": "R-DME-193763", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193793" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440378": { "compartment": "compartment_70101", "id": "reaction_10440378", "reactome": "R-DME-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440376": { "compartment": "compartment_70101", "id": "reaction_10440376", "reactome": "R-DME-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_193707", "species_29366" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440374": { "compartment": "compartment_70101", "id": "reaction_10440374", "reactome": "R-DME-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193724", "species_70106", "species_29364" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440372": { "compartment": "compartment_70101", "id": "reaction_10440372", "reactome": "R-DME-193743", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10440386": { "compartment": "compartment_70101", "id": "reaction_10440386", "reactome": "R-DME-193789", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192189", "species_29360" ], "products": [ "species_193724", "species_70106", "species_73473" ], "modifiers": [ [ "species_10440112", "catalyst" ] ], "additional_components": [ "FBgn0036698" ] }, "reaction_10440370": { "compartment": "compartment_17951", "id": "reaction_10440370", "reactome": "R-DME-193736", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440384": { "compartment": "compartment_70101", "id": "reaction_10440384", "reactome": "R-DME-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440368": { "compartment": "compartment_70101", "id": "reaction_10440368", "reactome": "R-DME-193727", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10457738": { "compartment": "compartment_70101", "id": "reaction_10457738", "reactome": "R-DME-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10434957", "species_74016" ], "products": [ "species_10434971" ], "modifiers": [], "additional_components": [ "P13677", "FBgn0004784", "P05130", "FBgn0003091", "species_114519", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "species_33625", "species_74016" ] }, "reaction_10457781": { "compartment": "compartment_70101", "id": "reaction_10457781", "reactome": "R-DME-1168633", "name": "NF-kappaB translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457765" ], "products": [ "species_10457779" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10457811": { "compartment": "compartment_70101", "id": "reaction_10457811", "reactome": "R-DME-1168640", "name": "Ubiquitinated IkB is degraded", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457809" ], "products": [ "species_10457765" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q03017", "phospho-cact", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10464584": { "compartment": "compartment_876", "id": "reaction_10464584", "reactome": "R-DME-2045911", "name": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_179838" ], "modifiers": [ [ "species_10464581", "catalyst" ] ], "additional_components": [ "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q9VFI0", "FBgn0020299" ] }, "reaction_10457751": { "compartment": "compartment_12045", "id": "reaction_10457751", "reactome": "R-DME-1168376", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457744" ], "products": [ "species_10457746", "species_74016" ], "modifiers": [ [ "species_10457748", "catalyst" ] ], "additional_components": [ "P83094", "Stim", "species_74016", "P83094", "Stim", "species_114520", "P29993", "FBgn0010051" ] }, "reaction_10464790": { "compartment": "compartment_876", "id": "reaction_10464790", "reactome": "R-DME-2076220", "name": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_179838" ], "modifiers": [ [ "species_10464787", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q08012", "FBgn0004638" ] }, "reaction_10464848": { "compartment": "compartment_12045", "id": "reaction_10464848", "reactome": "R-DME-2089927", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457746", "species_10464844" ], "products": [ "species_10464846" ], "modifiers": [], "additional_components": [ "P83094", "Stim", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "P83094", "Stim" ] }, "reaction_10458693": { "compartment": "compartment_876", "id": "reaction_10458693", "reactome": "R-DME-1296045", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458690", "catalyst" ] ], "additional_components": [ "B7YZX2", "FBgn0032706" ] }, "reaction_10458898": { "compartment": "compartment_876", "id": "reaction_10458898", "reactome": "R-DME-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458895", "catalyst" ] ], "additional_components": [ "Q94526", "FBgn0017561" ] }, "reaction_10456991": { "compartment": "compartment_17957", "id": "reaction_10456991", "reactome": "R-DME-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_983032" ], "products": [ "species_29372", "species_29370", "species_983034" ], "modifiers": [ [ "species_10456988", "catalyst" ] ], "additional_components": [ "Q9VRW2", "FBgn0035695", "Q5BI62", "FBgn0010241", "Q00748", "FBgn0004513", "Q00449", "FBgn0004512" ] }, "reaction_10457141": { "compartment": "compartment_17957", "id": "reaction_10457141", "reactome": "R-DME-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_8943716", "species_983033" ], "modifiers": [ [ "species_10457138", "catalyst" ] ], "additional_components": [ "Q9VJN2", "FBgn0028935", "Q0KI25", "FBgn0039064", "Q9VD87", "FBgn0038897", "Q0KI00", "FBgn0263236", "Q9VAM2", "FBgn0039656", "Q9W2S8", "FBgn0030222", "Q95SR0", "FBgn0051445", "Q9W2S7", "FBgn0030223", "Q8SWX4", "FBgn0051343", "Q9W1S1", "FBgn0046253", "Q8MRN5", "FBgn0051343", "Q9VTL4", "FBgn0036186", "Q8IRH1", "FBgn0261243" ] }, "reaction_10433208": { "compartment": "compartment_5460", "id": "reaction_10433208", "reactome": "R-DME-77327", "name": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77326", "species_113596" ], "products": [ "species_77324", "species_31649" ], "modifiers": [ [ "species_10433199", "catalyst" ] ], "additional_components": [ "Q9VDT1", "FBgn0038742" ] }, "reaction_10433206": { "compartment": "compartment_5460", "id": "reaction_10433206", "reactome": "R-DME-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77324", "species_113521" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433204": { "compartment": "compartment_5460", "id": "reaction_10433204", "reactome": "R-DME-77321", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77320" ], "products": [ "species_77318", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433212": { "compartment": "compartment_5460", "id": "reaction_10433212", "reactome": "R-DME-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433210": { "compartment": "compartment_5460", "id": "reaction_10433210", "reactome": "R-DME-77329", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77328" ], "products": [ "species_77326", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433222": { "compartment": "compartment_5460", "id": "reaction_10433222", "reactome": "R-DME-77338", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77337" ], "products": [ "species_77332", "species_31649" ], "modifiers": [ [ "species_10433219", "catalyst" ] ], "additional_components": [ "Q9VSA3", "FBgn0035811" ] }, "reaction_10433166": { "compartment": "compartment_5460", "id": "reaction_10433166", "reactome": "R-DME-77271", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77269" ], "products": [ "species_77261", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433172": { "compartment": "compartment_5460", "id": "reaction_10433172", "reactome": "R-DME-77283", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77276", "species_113526" ], "products": [ "species_113529", "species_77269", "species_29362" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433169": { "compartment": "compartment_5460", "id": "reaction_10433169", "reactome": "R-DME-77277", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77273", "species_113521" ], "products": [ "species_77276" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_210662": { "compartment": "compartment_70101", "id": "reaction_210662", "reactome": "R-DME-210662", "name": "Phosphorylated HOP is dephosphorylated by PTP61F isoform 1", "reversible": "false", "notes": "The Janus tyrosine kinase, Hopscotch (HOP) is dephosphorylated in the cytosol by the protein tyrosine phosphatase, PTP61F isoform 1.", "reactants": [ "species_206905" ], "products": [ "species_29372", "species_206753" ], "modifiers": [ [ "species_210628", "catalyst" ] ], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_210646": { "compartment": "compartment_70101", "id": "reaction_210646", "reactome": "R-DME-210646", "name": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1", "reversible": "false", "notes": "In the cytosol, phosphorylated STAT92E dimer is dephosphorylated on Tyr711 by the protein tyrosine phosphatase, PTP61F isoform 1.", "reactants": [ "species_207008" ], "products": [ "species_205965", "species_29372" ], "modifiers": [ [ "species_210628", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_210694": { "compartment": "compartment_7660", "id": "reaction_210694", "reactome": "R-DME-210694", "name": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2", "reversible": "false", "notes": "An alternative spliced form of the protein tyrosine phosphatase, PTP61FC (PTP61F isoform 2) is active in the nucleus and dephosphorylates the phosphorylated STAT92E dimer on Tyr711 resulting in its dissociation.", "reactants": [ "species_207031" ], "products": [ "species_113550", "species_206244" ], "modifiers": [ [ "species_210622", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_210687": { "compartment": "compartment_13231", "id": "reaction_210687", "reactome": "R-DME-210687", "name": "STAT92E transports from the nucleus to the cytosol", "reversible": "false", "notes": "Unphosphorylated STAT92E translocates from the nucleus to the cytosol.", "reactants": [ "species_206244" ], "products": [ "species_205965" ], "modifiers": [], "additional_components": [] }, "reaction_209307": { "compartment": "compartment_7660", "id": "reaction_209307", "reactome": "R-DME-209307", "name": "Phosphorylated STAT92E dimer activates transcription", "reversible": "false", "notes": "Once in the nucleus, the phosphorylated STAT92E dimer binds to a palindromic DNA sequence in the promoters of the pathway target genes. This now enables transcription to be activated.", "reactants": [ "species_207031" ], "products": [ "species_207031" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_209255": { "compartment": "compartment_984", "id": "reaction_209255", "reactome": "R-DME-209255", "name": "UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP", "reversible": "false", "notes": "The UPD (OS, UPD2, UPD3) family of ligands bind to the DOME:HOP dimer complex. Ligand binding suggests an induced conformational change in the DOME receptor that brings the HOP proteins, bound to the intracellular domains, closer together. The HOP tyrosine kinase is now activated.", "reactants": [ "species_206971", "species_206555" ], "products": [ "species_206753" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q9VWE0", "dome", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209336": { "compartment": "compartment_70101", "id": "reaction_209336", "reactome": "R-DME-209336", "name": "Activated HOP is autophosphorylated and/or transphosphorylated", "reversible": "false", "notes": "The activated HOPs phosphorylate themselves and each other. The precise residue position where this takes place is currently unknown as there are many potential phosphorylation sites on HOP.", "reactants": [ "species_113592", "species_206753" ], "products": [ "species_29370", "species_206905" ], "modifiers": [ [ "species_206753", "catalyst" ] ], "additional_components": [ "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209160": { "compartment": "compartment_70101", "id": "reaction_209160", "reactome": "R-DME-209160", "name": "Phosphorylated HOP phosphorylates DOME", "reversible": "false", "notes": "Tyr966 on the cytoplasmic tail of the DOME receptor is phosphorylated by phosphorylated HOP.", "reactants": [ "species_206905", "species_113592" ], "products": [ "species_206942", "species_29370" ], "modifiers": [ [ "species_206905", "catalyst" ] ], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome" ] }, "reaction_209231": { "compartment": "compartment_876", "id": "reaction_209231", "reactome": "R-DME-209231", "name": "DOME:HOP complex forms a dimer at the plasma membrane", "reversible": "false", "notes": "The HOP:DOME:DOME:HOP complex formation precedes ligand binding", "reactants": [ "species_206890" ], "products": [ "species_206971" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209245": { "compartment": "compartment_70101", "id": "reaction_209245", "reactome": "R-DME-209245", "name": "Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex", "reversible": "false", "notes": "The Domeless (DOME) cytokine receptor contains no tyrosine kinase domain. However, it is constitutively associated with the JAK tyrosine kinase, Hopscotch (HOP).", "reactants": [ "species_206172", "species_206271" ], "products": [ "species_206890" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209296": { "compartment": "compartment_7660", "id": "reaction_209296", "reactome": "R-DME-209296", "name": "SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription", "reversible": "false", "notes": "The negative pathway regulator SU(VAR)2-10 physically interacts with the phosphorylated STAT92E dimer and prevents it from binding to it's pathway target genes and so inhibiting transcription.SU(VAR)2-10 is a PIAS protein (protein inhibitors of activated STAT) and is also referred to as ZIMP protein.In vertebrates, PIAS proteins control the duration of JAK/STAT signalling by targeting active STAT for degradation by SUMOlation.", "reactants": [ "species_205759", "species_207031" ], "products": [ "species_206936" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E", "Q7KNF5", "SU(VAR)2-10" ] }, "reaction_210700": { "compartment": "compartment_7660", "id": "reaction_210700", "reactome": "R-DME-210700", "name": "KEN dimer represses transcription", "reversible": "false", "notes": "In the nucleus, the BCL6 orthologue, Ken and Barbie (KEN) dimer binds to GAAA sequences of the target gene DNA sequence. These overlap with some STAT92E binding sites and leads to transcription repression.", "reactants": [ "species_210679" ], "products": [ "species_210679" ], "modifiers": [], "additional_components": [ "O77459", "KEN", "O77459", "KEN" ] }, "reaction_209361": { "compartment": "compartment_70101", "id": "reaction_209361", "reactome": "R-DME-209361", "name": "STAT92E binds to phosphorylated HOP and phosphorylated DOME", "reversible": "false", "notes": "The phosphorylated residues on HOP and DOME form a docking site for the SH2 domains of STAT92E molecules and so a complex is formed involving these domains.", "reactants": [ "species_205965", "species_206942" ], "products": [ "species_206838" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E" ] }, "reaction_209365": { "compartment": "compartment_13231", "id": "reaction_209365", "reactome": "R-DME-209365", "name": "Phosphorylated STAT92E dimer transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated STAT92E dimer is translocated to the nucleus.", "reactants": [ "species_207008" ], "products": [ "species_207031" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_209210": { "compartment": "compartment_70101", "id": "reaction_209210", "reactome": "R-DME-209210", "name": "STAT92E is phosphorylated by phosphorylated HOP", "reversible": "false", "notes": "Tyr711 on STAT92E is phosphorylated by phosphorylated HOP tyrosine kinase.", "reactants": [ "species_113592", "species_206838" ], "products": [ "species_29370", "species_206806" ], "modifiers": [ [ "species_206838", "catalyst" ] ], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E", "Q24592", "phospho-hop", "Q24151", "Stat92E", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E" ] }, "reaction_209321": { "compartment": "compartment_70101", "id": "reaction_209321", "reactome": "R-DME-209321", "name": "Phosphorylated STAT92E dissociates from HOP and DOME and dimerises", "reversible": "false", "notes": "After STAT92E is phosphorylated, it dissociates from phosphorylated HOP and phosphorylated DOME or the receptor complex. The now free phosphorylated STAT92E forms a dimer with another phosphorylated STAT92E molecule. These dimers are stabilised by the interaction between the SH2 domain of one molecule and the phospho Tyr of the other.", "reactants": [ "species_206806" ], "products": [ "species_206942", "species_207008" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q24151", "Stat92E", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E" ] }, "reaction_10446644": { "compartment": "compartment_70101", "id": "reaction_10446644", "reactome": "R-DME-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10440775" ], "products": [ "species_29372", "species_10446639" ], "modifiers": [ [ "species_10440527", "catalyst" ] ], "additional_components": [] }, "reaction_10491859": { "compartment": "compartment_70101", "id": "reaction_10491859", "reactome": "R-DME-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10435578" ], "products": [ "species_10491851", "species_71285" ], "modifiers": [ [ "species_10491856", "catalyst" ] ], "additional_components": [ "P08736", "FBgn0284245", "P05303", "FBgn0000557", "P05303", "FBgn0000557", "P08736", "FBgn0284245", "FBgn0031777" ] }, "reaction_10491942": { "compartment": "compartment_70101", "id": "reaction_10491942", "reactome": "R-DME-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10435578" ], "products": [ "species_10491934", "species_71285" ], "modifiers": [ [ "species_10491939", "catalyst" ] ], "additional_components": [ "P08736", "FBgn0284245", "P05303", "FBgn0000557", "P05303", "FBgn0000557", "P08736", "FBgn0284245", "FBgn0031485" ] }, "reaction_10491880": { "compartment": "compartment_70101", "id": "reaction_10491880", "reactome": "R-DME-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10471517" ], "products": [ "species_71285", "species_10491872" ], "modifiers": [ [ "species_10491877", "catalyst" ] ], "additional_components": [ "FBgn0286784", "FBgn0286784", "FBgn0031003" ] }, "reaction_10491839": { "compartment": "compartment_70101", "id": "reaction_10491839", "reactome": "R-DME-8879123", "name": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10430268" ], "products": [ "species_10491831", "species_71285" ], "modifiers": [ [ "species_10491836", "catalyst" ] ], "additional_components": [ "FBgn0004867", "FBgn0004867", "FBgn0038306" ] }, "reaction_10490208": { "compartment": "compartment_876", "id": "reaction_10490208", "reactome": "R-DME-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461036", "species_10490194" ], "products": [ "species_10490201" ], "modifiers": [], "additional_components": [ "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10490368": { "compartment": "compartment_876", "id": "reaction_10490368", "reactome": "R-DME-8868661", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490203" ], "products": [ "species_29372", "species_10490359" ], "modifiers": [ [ "species_10490203", "catalyst" ] ], "additional_components": [ "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", 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"FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", 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"O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "Q7KLE5", "FBgn0027356", "P27619", "FBgn0003392", "species_29438", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772" ] }, "reaction_10489506": { "compartment": "compartment_876", "id": "reaction_10489506", "reactome": "R-DME-8862280", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489326", "species_10489339", "species_10489337", "species_10489331", "species_10439052", "species_10442542" ], "products": [ "species_10489341" ], "modifiers": [], "additional_components": [ "Q6AWD5", "FBgn0037702", "FBgn0037702", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "FBgn0032341", "FBgn0035060", "FBgn0023388", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q6AWD5", "FBgn0037702" ] }, "reaction_10490921": { "compartment": "compartment_24339", "id": "reaction_10490921", "reactome": "R-DME-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490919" ], "products": [ "species_10489311", "species_10490404" ], "modifiers": [], "additional_components": [ "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9V3I2", "FBgn0014010", "Q9VZ08", "FBgn0030286", "FBgn0015772", "Q9V3I2", "FBgn0014010", "species_29438", "Q9VZ08", "FBgn0030286", "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702" ] }, "reaction_10490923": { "compartment": "compartment_24339", "id": "reaction_10490923", "reactome": "R-DME-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490917", "species_10490352" ], "products": [ "species_10490919" ], "modifiers": [], "additional_components": [ "Q9V3I2", "FBgn0014010", "species_29420", "Q9VZ08", "FBgn0030286", "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9V3I2", "FBgn0014010", "Q9VZ08", "FBgn0030286" ] }, "reaction_10490925": { "compartment": "compartment_876", "id": "reaction_10490925", "reactome": "R-DME-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469475", "species_10447882", "species_179856" ], "products": [ "species_10489337" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10489357": { "compartment": "compartment_876", "id": "reaction_10489357", "reactome": "R-DME-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489311", "species_10489341", "species_10469475", "species_10447882", "species_10489347" ], "products": [ "species_10489349" ], "modifiers": [ [ "species_10489355", "catalyst" ] ], "additional_components": [ "FBgn0015772", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q6AWD5", "FBgn0037702", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9VXB0", "FBgn0030791", "Q9VXB0", "FBgn0030791", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9VTX5", "FBgn0020655", "P40946", "FBgn0013750", "species_29438" ] }, "reaction_10490190": { "compartment": "compartment_876", "id": "reaction_10490190", "reactome": "R-DME-8868230", "name": "SNX9 recruits components of the actin polymerizing machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490175", "species_10490171", "species_10490186", "species_10490184", "species_10469463", "species_10490179" ], "products": [ "species_10490188" ], "modifiers": [], "additional_components": [ "Q8MQJ8", "FBgn0036309", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "species_113592", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q8MQJ8", "FBgn0036309", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475" ] }, "reaction_10490130": { "compartment": "compartment_876", "id": "reaction_10490130", "reactome": "R-DME-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490118", "species_10489365" ], "products": [ "species_10490120" ], "modifiers": [], "additional_components": [ "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10490196": { "compartment": "compartment_876", "id": "reaction_10490196", "reactome": "R-DME-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490188", "species_10490192" ], "products": [ "species_10490194" ], "modifiers": [], "additional_components": [ "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "P27619", "FBgn0003392", "species_29438", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475" ] }, "reaction_10490133": { "compartment": "compartment_876", "id": "reaction_10490133", "reactome": "R-DME-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10447052", "catalyst" ] ], "additional_components": [ "FBgn0034789" ] }, "reaction_10490357": { "compartment": "compartment_24339", "id": "reaction_10490357", "reactome": "R-DME-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490350", "species_29356" ], "products": [ "species_29372", "species_10490354", "species_10490352" ], "modifiers": [ [ "species_10490350", "catalyst" ] ], "additional_components": [ "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490120", "species_10461053" ], "products": [ "species_10490122" ], "modifiers": [], "additional_components": [ "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "FBgn0015278", "Q7K3H0", "FBgn0015278", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10489368": { "compartment": "compartment_876", "id": "reaction_10489368", "reactome": "R-DME-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10489349" ], "products": [ "species_29370", "species_10489365" ], "modifiers": [ [ "species_10489349", "catalyst" ] ], "additional_components": [ "Q9VXB0", "FBgn0030791", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9VXB0", "FBgn0030791", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772" ] }, "reaction_10490138": { "compartment": "compartment_876", "id": "reaction_10490138", "reactome": "R-DME-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10490122", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10490363": { "compartment": "compartment_24339", "id": "reaction_10490363", "reactome": "R-DME-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490359", "species_10447997" ], "products": [ "species_10490361" ], "modifiers": [], "additional_components": [ "P27619", "FBgn0003392", "species_29420", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "FBgn0037218", "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q8MQJ8", "FBgn0036309", "Q9VMY8", "FBgn0037218", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9VJ30", "FBgn0015772" ] }, "reaction_10490365": { "compartment": "compartment_24339", "id": "reaction_10490365", "reactome": "R-DME-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471267", "species_10490361" ], "products": [ "species_10490350" ], "modifiers": [], "additional_components": [ "P11147", "FBgn0266599", "species_113592", "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q8MQJ8", "FBgn0036309", "Q9VMY8", "FBgn0037218", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9VJ30", "FBgn0015772", "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q8MQJ8", "FBgn0036309", "Q9VMY8", "FBgn0037218", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "P11147", "FBgn0266599", "Q9VJ30", "FBgn0015772" ] }, "reaction_10490206": { "compartment": "compartment_876", "id": "reaction_10490206", "reactome": "R-DME-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490201" ], "products": [ "species_29372", "species_10490203" ], "modifiers": [ [ "species_10490201", "catalyst" ] ], "additional_components": [ "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", 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"FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "Q7KLE5", "FBgn0027356", "P27619", "FBgn0003392", "species_29438", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10439917": { "compartment": "compartment_70101", "id": "reaction_10439917", "reactome": "R-DME-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439913" ], "products": [], "modifiers": [], "additional_components": [ "P98081", "FBgn0000414", "O62530", "FBgn0263351", "Q01989", "FBgn0011225" ] }, "reaction_10439915": { "compartment": "compartment_876", "id": "reaction_10439915", "reactome": "R-DME-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439857", "species_10439852" ], "products": [ "species_10439913" ], "modifiers": [], "additional_components": [ "FBgn0011225", "P98081", "FBgn0000414", "O62530", "FBgn0263351", "P98081", "FBgn0000414", "O62530", "FBgn0263351", "Q01989", "FBgn0011225" ] }, "reaction_10440628": { "compartment": "compartment_876", "id": "reaction_10440628", "reactome": "R-DME-196026", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439834", "species_10439839" ], "products": [ "species_10439841" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "FBgn0000414", "P98081", "FBgn0000414", "O62530", "FBgn0263351" ] }, "reaction_10440626": { "compartment": "compartment_876", "id": "reaction_10440626", "reactome": "R-DME-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439841", "species_10439850" ], "products": [ "species_10439852" ], "modifiers": [], "additional_components": [ "P98081", "FBgn0000414", "O62530", "FBgn0263351", "P98081", "FBgn0000414", "O62530", "FBgn0263351" ] }, "reaction_10486354": { "compartment": "compartment_6791047", "id": "reaction_10486354", "reactome": "R-DME-6807866", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486350", "species_10486342" ], "products": [ "species_10486352" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29420", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10486755": { "compartment": "compartment_20699", "id": "reaction_10486755", "reactome": "R-DME-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10486749", "species_10478727" ], "products": [ "species_10486753" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "Q9W3M8", "FBgn0260858", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9W3M8", "FBgn0260858", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "Q23983", "FBgn0250791" ] }, "reaction_10486564": { "compartment": "compartment_6791047", "id": "reaction_10486564", "reactome": "R-DME-6807877", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486475" ], "products": [ "species_10486350", "species_10486421", "species_10486340", "species_10486561" ], "modifiers": [ [ "species_10486475", "catalyst" ] ], "additional_components": [ "Q0KIE7", "FBgn0011747", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9W3M8", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "P40945", "FBgn0013749", "species_29420", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "FBgn0264560", "Q0KIE7", "FBgn0011747", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9W3N6", "FBgn0040087", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VVX6", "FBgn0260857", "O76767", "FBgn0267330", "Q9W3M8", "FBgn0260858", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q0KIE7", "FBgn0011747", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9W3M8", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789" ] }, "reaction_10486407": { "compartment": "compartment_6791047", "id": "reaction_10486407", "reactome": "R-DME-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486358", "species_10486403" ], "products": [ "species_10486405" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087" ] }, "reaction_10486344": { "compartment": "compartment_6791047", "id": "reaction_10486344", "reactome": "R-DME-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478691", "species_10486340", "species_10486338" ], "products": [ "species_10486342" ], "modifiers": [], "additional_components": [ "Q9W3N6", "FBgn0040087", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087" ] }, "reaction_10486361": { "compartment": "compartment_6791047", "id": "reaction_10486361", "reactome": "R-DME-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10486352" ], "products": [ "species_29370", "species_10486358" ], "modifiers": [ [ "species_10486352", "catalyst" ] ], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "P40945", "FBgn0013749", "species_29420", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10486587": { "compartment": "compartment_432051", "id": "reaction_10486587", "reactome": "R-DME-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473488", "species_10486561" ], "products": [ "species_10486585" ], "modifiers": [], "additional_components": [ "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420", "Q0KIE7", "FBgn0011747", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9W3N6", "FBgn0040087", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VVX6", "FBgn0260857", "O76767", "FBgn0267330", "Q9W3M8", "FBgn0260858", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q0KIE7", "FBgn0011747", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9W3N6", "FBgn0040087", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VVX6", "FBgn0260857", "O76767", "FBgn0267330", "Q9W3M8", "FBgn0260858", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29420" ] }, "reaction_10486477": { "compartment": "compartment_6791047", "id": "reaction_10486477", "reactome": "R-DME-6807875", "name": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486473", "species_10478762", "species_10486421", "species_10486405", "species_10486467", "species_10486450", "species_10449902" ], "products": [ "species_10486475" ], "modifiers": [], "additional_components": [ "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "FBgn0011747", "Q0KIE7", "FBgn0011747", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9W3M8", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789" ] }, "reaction_10486751": { "compartment": "compartment_20699", "id": "reaction_10486751", "reactome": "R-DME-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486730", "species_10486745" ], "products": [ "species_10486747" ], "modifiers": [], "additional_components": [ "Q9VMD2", "FBgn0031818", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "Q0KIE7", "FBgn0011747", "Q9W3M8", "FBgn0260858", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W3N6", "FBgn0040087", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "Q9VMD2", "FBgn0031818", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "Q0KIE7", "FBgn0011747", "Q9W3M8", "FBgn0260858", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W3N6", "FBgn0040087", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401" ] }, "reaction_10478860": { "compartment": "compartment_12045", "id": "reaction_10478860", "reactome": "R-DME-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478856", "species_10478844" ], "products": [ "species_10478858" ], "modifiers": [], "additional_components": [ "Q9V3A8", "FBgn0035909", "Q7JYA0", "FBgn0033873", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q7JYA0", "FBgn0033873", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3A8", "FBgn0035909" ] }, "reaction_10478888": { "compartment": "compartment_12045", "id": "reaction_10478888", "reactome": "R-DME-5694442", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478884", "species_10478868" ], "products": [ "species_10478886" ], "modifiers": [], "additional_components": [ "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "FBgn0000339", "P49858", "FBgn0000339", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401" ] }, "reaction_10478866": { "compartment": "compartment_12045", "id": "reaction_10478866", "reactome": "R-DME-5694433", "name": "MIA2 binds PREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442366", "species_10478862" ], "products": [ "species_10478864" ], "modifiers": [], "additional_components": [ "FBgn0031779", "FBgn0286898", "Q9VMH4", "FBgn0031779", "Q9VMA7", "FBgn0286898" ] }, "reaction_10488161": { "compartment": "compartment_20699", "id": "reaction_10488161", "reactome": "R-DME-8849348", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488142", "species_10488157", "species_10488144" ], "products": [ "species_10488159" ], "modifiers": [], "additional_components": [ "O18334", "Rab6", "species_29438", "P16568", "FBgn0000183", "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438" ] }, "reaction_10488321": { "compartment": "compartment_12045", "id": "reaction_10488321", "reactome": "R-DME-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488317", "species_10488198" ], "products": [ "species_10488319" ], "modifiers": [], "additional_components": [ "Q9W4A0", "FBgn0015794", "species_29420", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29420" ] }, "reaction_10488324": { "compartment": "compartment_12045", "id": "reaction_10488324", "reactome": "R-DME-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488319", "species_29438" ], "products": [ "species_29420", "species_10488204" ], "modifiers": [ [ "species_10488319", "catalyst" ] ], "additional_components": [ "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29420", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29438", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29420" ] }, "reaction_10487912": { "compartment": "compartment_20699", "id": "reaction_10487912", "reactome": "R-DME-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10488138": { "compartment": "compartment_20699", "id": "reaction_10488138", "reactome": "R-DME-8849345", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_8848483" ], "products": [ "species_429785", "species_76194" ], "modifiers": [ [ "species_10488135", "catalyst" ] ], "additional_components": [ "D5AEK7", "FBgn0036623", "Q9VV49", "FBgn0036622" ] }, "reaction_10488172": { "compartment": "compartment_20699", "id": "reaction_10488172", "reactome": "R-DME-8849350", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488159", "species_10488168" ], "products": [ "species_10488170", "species_10488166" ], "modifiers": [], "additional_components": [ "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "Q7KNS3", "FBgn0015754", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420", "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29420", "FBgn0015754" ] }, "reaction_10488206": { "compartment": "compartment_12045", "id": "reaction_10488206", "reactome": "R-DME-8849353", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488170", "species_113592" ], "products": [ "species_10473488", "species_10488157", "species_29370", "species_10488186" ], "modifiers": [ [ "species_10488204", "catalyst" ], [ "species_8848483", "catalyst" ] ], "additional_components": [ "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29420", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "Q6WV17", "FBgn0031681", "Q6WV19", "FBgn0031530", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29438" ] }, "reaction_10486977": { "compartment": "compartment_20699", "id": "reaction_10486977", "reactome": "R-DME-6811418", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486962" ], "products": [ "species_10486350", "species_10486974", "species_10486421", "species_10486340" ], "modifiers": [ [ "species_10486962", "catalyst" ] ], "additional_components": [ "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "M9PGI6", "FBgn0260855", "P40945", "FBgn0013749", "species_29420", "M9PGI6", "FBgn0260855", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "O76767", "FBgn0267330", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "FBgn0264560", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "M9PGI6", "FBgn0260855" ] }, "reaction_10487089": { "compartment": "compartment_12045", "id": "reaction_10487089", "reactome": "R-DME-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487087" ], "products": [ "species_10487085", "species_10487003", "species_10487051", "species_10478404", "species_10486403" ], "modifiers": [], "additional_components": [ "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "Q8I0G5", "FBgn0028968", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9VYT6", "FBgn0030341", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "Q9VS46", "FBgn0035762", "Q9W4X9", "FBgn0004643", "O76767", "FBgn0267330", "O18405", "FBgn0019925", "O76767", "FBgn0267330", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "M9PGI6", "FBgn0260855", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "Q9VYT6", "FBgn0030341", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "species_29420", "O18332", "FBgn0285937", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496" ] }, "reaction_10486947": { "compartment": "compartment_20699", "id": "reaction_10486947", "reactome": "R-DME-6811412", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486943", "species_10486403" ], "products": [ "species_10486945" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560" ] }, "reaction_10486964": { "compartment": "compartment_20699", "id": "reaction_10486964", "reactome": "R-DME-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486954", "species_10486421", "species_10486708", "species_10486945", "species_10486960" ], "products": [ "species_10486962" ], "modifiers": [], "additional_components": [ "FBgn0260855", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "M9PGI6", "FBgn0260855" ] }, "reaction_10486950": { "compartment": "compartment_20699", "id": "reaction_10486950", "reactome": "R-DME-6811414", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10486939" ], "products": [ "species_10486943", "species_29420" ], "modifiers": [ [ "species_10486939", "catalyst" ] ], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "P40945", "FBgn0013749", "species_29420", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10486999": { "compartment": "compartment_12045", "id": "reaction_10486999", "reactome": "R-DME-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10486996" ], "products": [ "species_10478736", "species_29372", "species_10486987", "species_10478727", "species_10486982", "species_10478669", "species_10486992" ], "modifiers": [ [ "species_10486996", "catalyst" ] ], "additional_components": [ "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791", "Q23983", "FBgn0250791", "FBgn0039212", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "FBgn0037383", "FBgn0260855", "FBgn0035965", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10486952": { "compartment": "compartment_20699", "id": "reaction_10486952", "reactome": "R-DME-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486678", "species_10486340" ], "products": [ "species_10486937" ], "modifiers": [], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560" ] }, "reaction_10486941": { "compartment": "compartment_20699", "id": "reaction_10486941", "reactome": "R-DME-6811411", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486350", "species_10486937" ], "products": [ "species_10486939" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29420", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10487005": { "compartment": "compartment_12045", "id": "reaction_10487005", "reactome": "R-DME-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10487003", "species_10478727" ], "products": [ "species_10486996" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "M9PGI6", "FBgn0260855", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487007": { "compartment": "compartment_432051", "id": "reaction_10487007", "reactome": "R-DME-6811426", "name": "Retrograde COPI vesicles bind kinesin and microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486974", "species_10457347" ], "products": [ "species_10487001" ], "modifiers": [], "additional_components": [ "M9PGI6", "FBgn0260855", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "O76767", "FBgn0267330", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379", "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379", "M9PGI6", "FBgn0260855", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "O76767", "FBgn0267330", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341" ] }, "reaction_10487616": { "compartment": "compartment_263163", "id": "reaction_10487616", "reactome": "R-DME-6814684", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10487612", "species_10478727" ], "products": [ "species_10487614" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "Q9VR90", "FBgn0031106", "Q9W0N6", "FBgn0260862", "Q7JY00", "FBgn0037084", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9VR90", "FBgn0031106", "Q9W0N6", "FBgn0260862", "Q7JY00", "FBgn0037084", "Q23983", "FBgn0250791" ] }, "reaction_10487651": { "compartment": "compartment_263163", "id": "reaction_10487651", "reactome": "R-DME-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487644" ], "products": [ "species_10487648" ], "modifiers": [ [ "species_10487644", "catalyst" ] ], "additional_components": [ "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29438", "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29420", "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29438" ] }, "reaction_10487252": { "compartment": "compartment_263163", "id": "reaction_10487252", "reactome": "R-DME-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487206", "species_10487248" ], "products": [ "species_10487250" ], "modifiers": [], "additional_components": [ "P25160", "FBgn0000115", "species_29438", "Q9W389", "FBgn0030088", "Q9VHP1", "FBgn0037603", "Q9VGE4", "FBgn0037979", "Q9W1R3", "FBgn0034854", "Q9VGR1", "FBgn0037881", "Q7K4K7", "FBgn0086757", "Q9W3V2", "FBgn0029912", "Q9VGE4", "FBgn0037979", "Q9W1R3", "FBgn0034854", "Q9VGR1", "FBgn0037881", "Q7K4K7", "FBgn0086757", "Q9W3V2", "FBgn0029912", "P25160", "FBgn0000115", "species_29438", "Q9W389", "FBgn0030088", "Q9VHP1", "FBgn0037603" ] }, "reaction_10487270": { "compartment": "compartment_70101", "id": "reaction_10487270", "reactome": "R-DME-6814096", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487266", "species_10487200" ], "products": [ "species_10487268" ], "modifiers": [], "additional_components": [ "FBgn0039505", "species_29438", "P25160", "FBgn0000115", "species_29438", "P25160", "FBgn0000115", "Q9VB51", "FBgn0039505" ] }, "reaction_10487655": { "compartment": "compartment_263163", "id": "reaction_10487655", "reactome": "R-DME-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487642", "species_10487653" ], "products": [ "species_10487644" ], "modifiers": [], "additional_components": [ "O18339", "FBgn0015793", "species_29438", "FBgn0020620", "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29438" ] }, "reaction_10487208": { "compartment": "compartment_263163", "id": "reaction_10487208", "reactome": "R-DME-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487192", "species_10487200" ], "products": [ "species_10487206" ], "modifiers": [], "additional_components": [ "Q9W389", "FBgn0030088", "species_29438", "Q9VHP1", "FBgn0037603", "species_29438", "P25160", "FBgn0000115", "P25160", "FBgn0000115", "species_29438", "Q9W389", "FBgn0030088", "Q9VHP1", "FBgn0037603" ] }, "reaction_10487562": { "compartment": "compartment_263163", "id": "reaction_10487562", "reactome": "R-DME-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10478727", "species_10487552" ], "products": [ "species_10487560" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487261": { "compartment": "compartment_70101", "id": "reaction_10487261", "reactome": "R-DME-6814094", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487257", "species_10487200" ], "products": [ "species_10487259" ], "modifiers": [], "additional_components": [ "FBgn0037884", "species_29438", "P25160", "FBgn0000115", "species_29438", "P25160", "FBgn0000115", "Q9VGQ8", "FBgn0037884" ] }, "reaction_10487565": { "compartment": "compartment_263163", "id": "reaction_10487565", "reactome": "R-DME-6814678", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487560" ], "products": [ "species_10478736", "species_29370", "species_10478727", "species_10487508", "species_10487522", "species_10487506", "species_10487504" ], "modifiers": [ [ "species_10487560", "catalyst" ] ], "additional_components": [ "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791", "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "FBgn0260862", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "FBgn0031106", "FBgn0037084", "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487214": { "compartment": "compartment_263163", "id": "reaction_10487214", "reactome": "R-DME-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487182", "species_10487212" ], "products": [ "species_10487192" ], "modifiers": [], "additional_components": [ "FBgn0037603", "Q9W389", "FBgn0030088", "species_29438", "Q9W389", "FBgn0030088", "species_29438", "Q9VHP1", "FBgn0037603" ] }, "reaction_10447993": { "compartment": "compartment_70101", "id": "reaction_10447993", "reactome": "R-DME-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447892" ], "products": [ "species_10439074", "species_29372", "species_29420", "species_10447990", "species_10447884" ], "modifiers": [ [ "species_10447892", "catalyst" ] ], "additional_components": [ "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P27619", "FBgn0003392", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P27619", "FBgn0003392", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833" ] }, "reaction_10447894": { "compartment": "compartment_20699", "id": "reaction_10447894", "reactome": "R-DME-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439074", "species_10447876", "species_10447882", "species_10447884" ], "products": [ "species_29372", "species_10447892", "species_10444042" ], "modifiers": [], "additional_components": [ "FBgn0038659", "P61209", "FBgn0010348", "species_29438", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P27619", "FBgn0003392", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P61209", "FBgn0010348", "species_29420" ] }, "reaction_10449633": { "compartment": "compartment_70101", "id": "reaction_10449633", "reactome": "R-DME-434362", "name": "Recruitment Of Cytoplasmic Proteins To Vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447984", "species_10449619", "species_10449624", "species_10449610", "species_10449629" ], "products": [ "species_10447984", "species_10449631" ], "modifiers": [], "additional_components": [ "Q9VYH1", "FBgn0030449", "FBgn0003165", "FBgn0261279", "FBgn0010877", "Q9VE96", "FBgn0010877", "Q8IN05", "FBgn0261279", "P25822", "FBgn0003165", "Q9VYH1", "FBgn0030449" ] }, "reaction_10475663": { "compartment": "compartment_20699", "id": "reaction_10475663", "reactome": "R-DME-5671702", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439057", "species_10454937", "species_10475659" ], "products": [ "species_10475661" ], "modifiers": [], "additional_components": [ "FBgn0031450", "FBgn0039402", "FBgn0030089", "Q7KVR8", "FBgn0030089", "Q9VBI3", "FBgn0039402", "Q960X8", "FBgn0031450" ] }, "reaction_10449498": { "compartment": "compartment_70101", "id": "reaction_10449498", "reactome": "R-DME-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449493" ], "products": [ "species_10439074", "species_29372", "species_10449475", "species_29420", "species_10447884" ], "modifiers": [ [ "species_10449493", "catalyst" ] ], "additional_components": [ "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P27619", "FBgn0003392", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P27619", "FBgn0003392" ] }, "reaction_10449495": { "compartment": "compartment_70101", "id": "reaction_10449495", "reactome": "R-DME-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449489", "species_10439074", "species_10447882", "species_10447884" ], "products": [ "species_29372", "species_10449493", "species_10444042" ], "modifiers": [], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P27619", "FBgn0003392", "P61209", "FBgn0010348", "species_29420" ] }, "reaction_10471574": { "compartment": "compartment_263163", "id": "reaction_10471574", "reactome": "R-DME-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10471570" ], "products": [ "species_10471572" ], "modifiers": [], "additional_components": [ "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "B8A403", "FBgn0039132", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "P29742", "FBgn0000319", "species_1806289", "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "B8A403", "FBgn0039132", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "P29742", "FBgn0000319" ] }, "reaction_10444054": { "compartment": "compartment_70101", "id": "reaction_10444054", "reactome": "R-DME-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10444042" ], "products": [ "species_29420", "species_10444046" ], "modifiers": [ [ "species_10444051", "catalyst" ] ], "additional_components": [ "P61209", "FBgn0010348", "species_29420", "P61209", "FBgn0010348", "species_29438", "FBgn0264560" ] }, "reaction_10455085": { "compartment": "compartment_70101", "id": "reaction_10455085", "reactome": "R-DME-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454980", "species_10455081" ], "products": [ "species_10455014", "species_10455079" ], "modifiers": [], "additional_components": [ "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027" ] }, "reaction_10455083": { "compartment": "compartment_70101", "id": "reaction_10455083", "reactome": "R-DME-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455062", "species_10455079" ], "products": [ "species_10455060", "species_10455081" ], "modifiers": [], "additional_components": [ "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027", "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10455091": { "compartment": "compartment_876", "id": "reaction_10455091", "reactome": "R-DME-917730", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455089", "species_10455060" ], "products": [ "species_10455062", "species_10455087" ], "modifiers": [], "additional_components": [ "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450" ] }, "reaction_10465199": { "compartment": "compartment_984", "id": "reaction_10465199", "reactome": "R-DME-2168886", "name": "Hemopexin binds Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310", "species_10465195" ], "products": [ "species_10465197" ], "modifiers": [], "additional_components": [ "species_71185", "FBgn0035049", "Q9W122", "FBgn0035049", "species_71185" ] }, "reaction_10442798": { "compartment": "compartment_70101", "id": "reaction_10442798", "reactome": "R-DME-209859", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209911" ], "products": [ "species_113528", "species_209914" ], "modifiers": [ [ "species_10442795", "catalyst" ] ], "additional_components": [ "P05031", "FBgn0000422" ] }, "reaction_10442780": { "compartment": "compartment_70101", "id": "reaction_10442780", "reactome": "R-DME-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29500", "species_29368" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10442777", "catalyst" ] ], "additional_components": [ "Q9W0K2", "FBgn0035187", "species_111793" ] }, "reaction_10449260": { "compartment": "compartment_70101", "id": "reaction_10449260", "reactome": "R-DME-432148", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448753", "species_113592" ], "products": [ "species_29370", "species_10439430" ], "modifiers": [ [ "species_10449257", "catalyst" ] ], "additional_components": [ "FBgn0024846", "FBgn0024846", "FBgn0262733" ] }, "reaction_10447546": { "compartment": "compartment_70101", "id": "reaction_10447546", "reactome": "R-DME-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10447543", "catalyst" ] ], "additional_components": [ "Q9VJ79", "FBgn0085370", "Q9VFI9", "FBgn0038237", "B7YZV4", "FBgn0264815" ] }, "reaction_10447521": { "compartment": "compartment_70101", "id": "reaction_10447521", "reactome": "R-DME-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10447516", "catalyst" ] ], "additional_components": [ "FBgn0011676" ] }, "reaction_10448285": { "compartment": "compartment_876", "id": "reaction_10448285", "reactome": "R-DME-426223", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426219" ], "products": [ "species_426221" ], "modifiers": [ [ "species_10448280", "catalyst" ] ], "additional_components": [ "species_74113", "species_74016", "species_29926", "species_74016", "species_29926", "species_74113", "species_114519", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861" ] }, "reaction_10484607": { "compartment": "compartment_7660", "id": "reaction_10484607", "reactome": "R-DME-6799431", "name": "TP53 binds HIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467611", "species_10484603" ], "products": [ "species_10484605" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0035142", "Q9W0Q1", "FBgn0035142", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486113": { "compartment": "compartment_7660", "id": "reaction_10486113", "reactome": "R-DME-6805276", "name": "CDK5 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_113582", "species_10486103" ], "modifiers": [ [ "species_10486110", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P48609", "FBgn0013762", "Q9V3H5", "FBgn0027491" ] }, "reaction_10486083": { "compartment": "compartment_7660", "id": "reaction_10486083", "reactome": "R-DME-6805109", "name": "CDK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_113582", "species_10486081" ], "modifiers": [ [ "species_10427405", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P23573", "FBgn0004107" ] }, "reaction_10484601": { "compartment": "compartment_7660", "id": "reaction_10484601", "reactome": "R-DME-6799409", "name": "HIPK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467602" ], "products": [ "species_10467600", "species_113582", "species_10467592", "species_10481386" ], "modifiers": [ [ "species_10467602", "catalyst" ] ], "additional_components": [ "M9NFM7", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "M9NFM7", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379" ] }, "reaction_10486087": { "compartment": "compartment_7660", "id": "reaction_10486087", "reactome": "R-DME-6805122", "name": "AURKB binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470050", "species_10467755" ], "products": [ "species_10486085" ], "modifiers": [], "additional_components": [ "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227" ] }, "reaction_10486121": { "compartment": "compartment_7660", "id": "reaction_10486121", "reactome": "R-DME-6805399", "name": "TAF1 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_113582", "species_10486118" ], "modifiers": [ [ "species_10431420", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10467604": { "compartment": "compartment_7660", "id": "reaction_10467604", "reactome": "R-DME-3215251", "name": "TP53INP1 and HIPK2 bind TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467600", "species_10427813", "species_10467592" ], "products": [ "species_10467602" ], "modifiers": [], "additional_components": [ "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379", "Q8IMZ4", "FBgn0039044", "FBgn0035542", "M9NFM7", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379" ] }, "reaction_10481389": { "compartment": "compartment_7660", "id": "reaction_10481389", "reactome": "R-DME-6798374", "name": "DYRK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427813" ], "products": [ "species_113582", "species_10481386" ], "modifiers": [ [ "species_10481378", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0027101" ] }, "reaction_10467757": { "compartment": "compartment_7660", "id": "reaction_10467757", "reactome": "R-DME-3222128", "name": "NOC2L binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10467753" ], "products": [ "species_10467755" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0032925", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486098": { "compartment": "compartment_7660", "id": "reaction_10486098", "reactome": "R-DME-6805126", "name": "AURKB phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10486085" ], "products": [ "species_10486095", "species_113582" ], "modifiers": [ [ "species_10486085", "catalyst" ] ], "additional_components": [ "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227" ] }, "reaction_10486134": { "compartment": "compartment_7660", "id": "reaction_10486134", "reactome": "R-DME-6805470", "name": "AMPK phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_10427808", "species_113582" ], "modifiers": [ [ "species_10486131", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "O18645", "FBgn0023169", "A1Z7Q8", "FBgn0260972", "species_76577", "Q9VDD2", "FBgn0264357" ] }, "reaction_10486074": { "compartment": "compartment_7660", "id": "reaction_10486074", "reactome": "R-DME-6805059", "name": "CK2:FACT phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427813" ], "products": [ "species_113582", "species_10486053" ], "modifiers": [ [ "species_10486071", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278" ] }, "reaction_10486076": { "compartment": "compartment_7660", "id": "reaction_10486076", "reactome": "R-DME-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434698", "species_10486069" ], "products": [ "species_10486071" ], "modifiers": [], "additional_components": [ "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278" ] }, "reaction_10486142": { "compartment": "compartment_7660", "id": "reaction_10486142", "reactome": "R-DME-6805479", "name": "TP53RK phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_10427808", "species_113582" ], "modifiers": [ [ "species_10486139", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0035590" ] }, "reaction_10486000": { "compartment": "compartment_7660", "id": "reaction_10486000", "reactome": "R-DME-6804402", "name": "TP53 binds POU4F1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485996", "species_10427813" ], "products": [ "species_10485998" ], "modifiers": [], "additional_components": [ "FBgn0000028", "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P24350", "FBgn0000028" ] }, "reaction_10486006": { "compartment": "compartment_7660", "id": "reaction_10486006", "reactome": "R-DME-6804425", "name": "TP53 binds POU4F2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10486002" ], "products": [ "species_10486004" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0000028", "P24350", "FBgn0000028", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10467785": { "compartment": "compartment_7660", "id": "reaction_10467785", "reactome": "R-DME-3222259", "name": "PHF20 binds TP53 dimethylated on K370 and K382", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467781", "species_10467775" ], "products": [ "species_10467783" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0038016", "Q9VGA4", "FBgn0038016", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486215": { "compartment": "compartment_7660", "id": "reaction_10486215", "reactome": "R-DME-6805785", "name": "AKT phosphorylates PHF20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467775" ], "products": [ "species_113582", "species_10486213" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0038016", "FBgn0038016" ] }, "reaction_10484676": { "compartment": "compartment_7660", "id": "reaction_10484676", "reactome": "R-DME-6799777", "name": "TP53 family members bind PPP1R13B or TP53BP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481317", "species_10484670" ], "products": [ "species_10484674" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0034606", "Q86BG1", "FBgn0034606", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486219": { "compartment": "compartment_7660", "id": "reaction_10486219", "reactome": "R-DME-6805792", "name": "p-S291-PHF20 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486213" ], "products": [ "species_10486217" ], "modifiers": [], "additional_components": [ "FBgn0038016", "FBgn0038016" ] }, "reaction_10486046": { "compartment": "compartment_7660", "id": "reaction_10486046", "reactome": "R-DME-6804762", "name": "TP53 forms homotetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467282" ], "products": [ "species_10467611" ], "modifiers": [], "additional_components": [ "FBgn0039044", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10474397": { "compartment": "compartment_70101", "id": "reaction_10474397", "reactome": "R-DME-5632738", "name": "DDIT4 binds 14-3-3 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432018", "species_10474390" ], "products": [ "species_10474392" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "Q9VTH4", "FBgn0041094", "Q9VTI8", "FBgn0036165", "Q9VTH4", "FBgn0041094", "Q9VTI8", "FBgn0036165", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon" ] }, "reaction_10474394": { "compartment": "compartment_70101", "id": "reaction_10474394", "reactome": "R-DME-5632732", "name": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432018", "species_10440825" ], "products": [ "species_10474378" ], "modifiers": [ [ "species_10474392", "inhibitor" ] ], "additional_components": [ "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "FBgn0005198", "Q9VW83", "FBgn0005198", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "Q9VTH4", "FBgn0041094", "Q9VTI8", "FBgn0036165", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon" ] }, "reaction_10474353": { "compartment": "compartment_70101", "id": "reaction_10474353", "reactome": "R-DME-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474341", "species_10445887" ], "products": [ "species_10474351" ], "modifiers": [], "additional_components": [ "FBgn0034897", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9W1K5", "FBgn0034897" ] }, "reaction_10436944": { "compartment": "compartment_70101", "id": "reaction_10436944", "reactome": "R-DME-165179", "name": "Formation of TSC1:TSC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436938", "species_10436925" ], "products": [ "species_10436942" ], "modifiers": [], "additional_components": [ "FBgn0026317", "FBgn0005198", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317" ] }, "reaction_10474349": { "compartment": "compartment_70101", "id": "reaction_10474349", "reactome": "R-DME-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474341", "species_10474333" ], "products": [ "species_10474347" ], "modifiers": [], "additional_components": [ "FBgn0034897", "Q9V3P0", "FBgn0040309", "Q9V3P0", "FBgn0040309", "Q9W1K5", "FBgn0034897" ] }, "reaction_10474336": { "compartment": "compartment_70101", "id": "reaction_10474336", "reactome": "R-DME-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468393", "species_29408" ], "products": [ "species_29356", "species_10474333" ], "modifiers": [ [ "species_10468393", "catalyst" ] ], "additional_components": [ "Q9V3P0", "FBgn0040309", "Q9V3P0", "FBgn0040309", "Q9V3P0", "FBgn0040309" ] }, "reaction_10481119": { "compartment": "compartment_7660", "id": "reaction_10481119", "reactome": "R-DME-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434613", "species_10481115" ], "products": [ "species_10481117" ], "modifiers": [], "additional_components": [ "FBgn0025674", "FBgn0037093", "Q9VP22", "FBgn0037093", "Q961D1", "FBgn0025674" ] }, "reaction_10481276": { "compartment": "compartment_7660", "id": "reaction_10481276", "reactome": "R-DME-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481111", "species_10481256" ], "products": [ "species_10481258" ], "modifiers": [], "additional_components": [ "Q961D1", "FBgn0025674", "Q9VP22", "FBgn0037093", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9VP22", "FBgn0037093" ] }, "reaction_10481274": { "compartment": "compartment_7660", "id": "reaction_10481274", "reactome": "R-DME-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10481258" ], "products": [ "species_113582", "species_10481271" ], "modifiers": [ [ "species_10481258", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9VP22", "FBgn0037093", "Q961D1", "FBgn0025674", "Q9VP22", "FBgn0037093", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VW51", "FBgn0014037", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "P04052", "FBgn0003277", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9VP22", "FBgn0037093" ] }, "reaction_10481113": { "compartment": "compartment_7660", "id": "reaction_10481113", "reactome": "R-DME-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481109", "species_10434613" ], "products": [ "species_10481111" ], "modifiers": [], "additional_components": [ "FBgn0037093", "FBgn0025674", "Q961D1", "FBgn0025674", "Q9VP22", "FBgn0037093" ] }, "reaction_10485756": { "compartment": "compartment_70101", "id": "reaction_10485756", "reactome": "R-DME-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485748" ], "products": [ "species_10485754" ], "modifiers": [], "additional_components": [ "Q960C5", "FBgn0032633", "Q9W2D7", "FBgn0034655", "Q9W2D7", "FBgn0034655", "Q960C5", "FBgn0032633" ] }, "reaction_10485783": { "compartment": "compartment_70101", "id": "reaction_10485783", "reactome": "R-DME-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485772", "species_10485779" ], "products": [ "species_10485781" ], "modifiers": [], "additional_components": [ "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "FBgn0026378", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970" ] }, "reaction_10485774": { "compartment": "compartment_876", "id": "reaction_10485774", "reactome": "R-DME-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485770", "species_10485765" ], "products": [ "species_10485772" ], "modifiers": [], "additional_components": [ "FBgn0028970", "FBgn0037293", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970" ] }, "reaction_10485804": { "compartment": "compartment_17927", "id": "reaction_10485804", "reactome": "R-DME-6801242", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485788", "species_10485800" ], "products": [ "species_10485802" ], "modifiers": [], "additional_components": [ "FBgn0050109", "Q9V579", "FBgn0033413", "Q9V579", "FBgn0033413", "Q6NLJ9", "FBgn0050109" ] }, "reaction_10485807": { "compartment": "compartment_17906", "id": "reaction_10485807", "reactome": "R-DME-6801250", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590" ], "products": [ "species_1524101" ], "modifiers": [ [ "species_10485802", "catalyst" ] ], "additional_components": [ "Q9V579", "FBgn0033413", "Q6NLJ9", "FBgn0050109" ] }, "reaction_10430972": { "compartment": "compartment_70101", "id": "reaction_10430972", "reactome": "R-DME-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10430969", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_1562550", "Q9VLR3", "FBgn0032001" ] }, "reaction_10433723": { "compartment": "compartment_5460", "id": "reaction_10433723", "reactome": "R-DME-109759", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_500822" ], "products": [ "species_113581", "species_500823" ], "modifiers": [ [ "species_10433720", "catalyst" ] ], "additional_components": [ "CHEBI:17748", "CHEBI:16450", "CHEBI:15698", "species_109366", "species_109382", "CHEBI:15918", "FBgn0022338" ] }, "reaction_10431579": { "compartment": "compartment_70101", "id": "reaction_10431579", "reactome": "R-DME-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83962", "species_500244" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10431576", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "species_112016", "CHEBI:16450", "CHEBI:16704", "Q9VBA0", "FBgn0039464", "Q8T8S2", "FBgn0034800", "Q0E8U4", "FBgn0031489" ] }, "reaction_10433803": { "compartment": "compartment_70101", "id": "reaction_10433803", "reactome": "R-DME-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10433800", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_1524067", "species_418075", "Q9VC99", "FBgn0263398" ] }, "reaction_10430952": { "compartment": "compartment_70101", "id": "reaction_10430952", "reactome": "R-DME-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10430949", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_1524067", "species_418075", "Q9VC99", "FBgn0263398" ] }, "reaction_10479975": { "compartment": "compartment_70101", "id": "reaction_10479975", "reactome": "R-DME-6788295", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6788291" ], "products": [ "species_29372", "species_6788290" ], "modifiers": [ [ "species_10479972", "catalyst" ] ], "additional_components": [ "species_29926", "Q94529", "FBgn0019982" ] }, "reaction_10495070": { "compartment": "compartment_70101", "id": "reaction_10495070", "reactome": "R-DME-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10495067", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_1524067", "species_418075", "FBgn0022029" ] }, "reaction_10427902": { "compartment": "compartment_70101", "id": "reaction_10427902", "reactome": "R-DME-70361", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30170", "species_29410" ], "products": [ "species_29452", "species_29548" ], "modifiers": [ [ "species_10427899", "catalyst" ] ], "additional_components": [ "FBgn0263200" ] }, "reaction_10427912": { "compartment": "compartment_70101", "id": "reaction_10427912", "reactome": "R-DME-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10427909", "catalyst" ] ], "additional_components": [ "species_427523", "Q9W0P5", "FBgn0035147" ] }, "reaction_10427975": { "compartment": "compartment_70101", "id": "reaction_10427975", "reactome": "R-DME-70427", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10427861", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z7P1", "FBgn0033377", "A1Z9V3", "FBgn0033969" ] }, "reaction_10488852": { "compartment": "compartment_161320", "id": "reaction_10488852", "reactome": "R-DME-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10488849", "catalyst" ] ], "additional_components": [ "Q8IPB7", "FBgn0027611", "species_1562550" ] }, "reaction_10484649": { "compartment": "compartment_161320", "id": "reaction_10484649", "reactome": "R-DME-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10484646", "catalyst" ] ], "additional_components": [ "Q9VKV2", "FBgn0032253", "Q9VLI1", "FBgn0032067", "Q8IPB7", "FBgn0027611", "Q9VLI0", "FBgn0032068", "Q9VLH9", "FBgn0032069", "Q9VLI2", "FBgn0032066", "species_1562550" ] }, "reaction_10488857": { "compartment": "compartment_161320", "id": "reaction_10488857", "reactome": "R-DME-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10488854", "catalyst" ] ], "additional_components": [ "FBgn0037215" ] }, "reaction_10497920": { "compartment": "compartment_70101", "id": "reaction_10497920", "reactome": "R-DME-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10497917", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUY9", "FBgn0003076" ] }, "reaction_10428999": { "compartment": "compartment_70101", "id": "reaction_10428999", "reactome": "R-DME-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10428910" ], "products": [ "species_10428915", "species_29370" ], "modifiers": [ [ "species_10428996", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9XTL9", "FBgn0004507", "Q9XTL9", "FBgn0004507", "Q9VLS1", "FBgn0031995", "Q9W391", "FBgn0030087", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10451638": { "compartment": "compartment_70101", "id": "reaction_10451638", "reactome": "R-DME-453342", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428910", "species_76577" ], "products": [ "species_10451634" ], "modifiers": [ [ "species_30537", "inhibitor" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q9XTL9", "FBgn0004507", "species_76577", "Q9XTL9", "FBgn0004507" ] }, "reaction_10428063": { "compartment": "compartment_70101", "id": "reaction_10428063", "reactome": "R-DME-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10428060", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "species_29926", "A0A0U1RVK6", "FBgn0032820" ] }, "reaction_10468121": { "compartment": "compartment_17957", "id": "reaction_10468121", "reactome": "R-DME-3262512", "name": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10468118", "catalyst" ] ], "additional_components": [ "FBgn0031463" ] }, "reaction_10444376": { "compartment": "compartment_5460", "id": "reaction_10444376", "reactome": "R-DME-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_113525", "species_29376" ], "modifiers": [ [ "species_10444373", "catalyst" ] ], "additional_components": [ "FBgn0003067" ] }, "reaction_10444312": { "compartment": "compartment_70101", "id": "reaction_10444312", "reactome": "R-DME-372449", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_372364" ], "products": [ "species_29654", "species_29492" ], "modifiers": [ [ "species_10432422", "catalyst" ] ], "additional_components": [ "FBgn0037912" ] }, "reaction_10440823": { "compartment": "compartment_70101", "id": "reaction_10440823", "reactome": "R-DME-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10440820", "catalyst" ] ], "additional_components": [ "Q9VKX2", "FBgn0262782" ] }, "reaction_10427830": { "compartment": "compartment_70101", "id": "reaction_10427830", "reactome": "R-DME-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_29420", "species_113528", "species_29492" ], "modifiers": [ [ "species_10427827", "catalyst" ] ], "additional_components": [ "P20007", "FBgn0003067", "Q7JXB5", "FBgn0034356" ] }, "reaction_10428116": { "compartment": "compartment_5460", "id": "reaction_10428116", "reactome": "R-DME-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113557", "species_29376" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10428113", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "Q0E9E2", "FBgn0027580", "species_266099", "species_199238" ] }, "reaction_10468116": { "compartment": "compartment_70101", "id": "reaction_10468116", "reactome": "R-DME-3257122", "name": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10468111", "catalyst" ] ], "additional_components": [ "FBgn0034611" ] }, "reaction_10440813": { "compartment": "compartment_70101", "id": "reaction_10440813", "reactome": "R-DME-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10440810", "catalyst" ] ], "additional_components": [ "Q9VAJ9", "FBgn0039674" ] }, "reaction_10445386": { "compartment": "compartment_70101", "id": "reaction_10445386", "reactome": "R-DME-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10440810", "catalyst" ] ], "additional_components": [ "Q9VAJ9", "FBgn0039674" ] }, "reaction_10468169": { "compartment": "compartment_17957", "id": "reaction_10468169", "reactome": "R-DME-3266566", "name": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10468166", "catalyst" ] ], "additional_components": [ "FBgn0031463" ] }, "reaction_10428264": { "compartment": "compartment_5460", "id": "reaction_10428264", "reactome": "R-DME-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_113552" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10428224", "catalyst" ] ], "additional_components": [ "Q8IPY3", "FBgn0001125" ] }, "reaction_10429153": { "compartment": "compartment_17957", "id": "reaction_10429153", "reactome": "R-DME-71825", "name": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10429150", "catalyst" ] ], "additional_components": [ "FBgn0031463" ] }, "reaction_10474612": { "compartment": "compartment_70101", "id": "reaction_10474612", "reactome": "R-DME-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10440630", "catalyst" ] ], "additional_components": [ "FBgn0086254" ] }, "reaction_10474624": { "compartment": "compartment_70101", "id": "reaction_10474624", "reactome": "R-DME-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5652213", "species_29360" ], "products": [ "species_29532", "species_70106", "species_73473" ], "modifiers": [ [ "species_10474621", "catalyst" ] ], "additional_components": [ "species_1562550", "O96299", "FBgn0022359" ] }, "reaction_10427884": { "compartment": "compartment_70101", "id": "reaction_10427884", "reactome": "R-DME-70333", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29532", "species_113592" ], "products": [ "species_29370", "species_31221" ], "modifiers": [ [ "species_10427881", "catalyst" ], [ "species_29804", "catalyst" ], [ "species_29370", "inhibitor" ] ], "additional_components": [ "Q9VW84", "FBgn0036942" ] }, "reaction_10484615": { "compartment": "compartment_70101", "id": "reaction_10484615", "reactome": "R-DME-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799497", "species_113592" ], "products": [ "species_70106", "species_29370", "species_6799493" ], "modifiers": [ [ "species_10484612", "catalyst" ] ], "additional_components": [ "FBgn0031428" ] }, "reaction_10427894": { "compartment": "compartment_70101", "id": "reaction_10427894", "reactome": "R-DME-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_30393", "species_75970" ], "modifiers": [ [ "species_10427891", "catalyst" ] ], "additional_components": [ "P07764", "FBgn0000064" ] }, "reaction_10440638": { "compartment": "compartment_70101", "id": "reaction_10440638", "reactome": "R-DME-196372", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193124", "species_29360" ], "products": [ "species_196366", "species_70106", "species_73473" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10440398": { "compartment": "compartment_70101", "id": "reaction_10440398", "reactome": "R-DME-193961", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196366" ], "products": [ "species_193092" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10459245": { "compartment": "compartment_984", "id": "reaction_10459245", "reactome": "R-DME-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1449707", "species_10459241" ], "products": [ "species_10459243" ], "modifiers": [], "additional_components": [ "CHEBI:27584", "species_193055", "species_193977", "CHEBI:16973", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "CHEBI:27584", "species_193055", "species_193977", "CHEBI:16973" ] }, "reaction_10440406": { "compartment": "compartment_17957", "id": "reaction_10440406", "reactome": "R-DME-194023", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193977", "species_29366" ], "products": [ "species_70106", "species_29364", "species_194035" ], "modifiers": [ [ "species_10440403", "catalyst" ] ], "additional_components": [ "FBgn0000056" ] }, "reaction_10489504": { "compartment": "compartment_70101", "id": "reaction_10489504", "reactome": "R-DME-8862137", "name": "HSD17B2 oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10489501", "catalyst" ] ], "additional_components": [ "FBgn0000056" ] }, "reaction_10479237": { "compartment": "compartment_5460", "id": "reaction_10479237", "reactome": "R-DME-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_5696835" ], "products": [ "species_113529", "species_5696848", "species_113600" ], "modifiers": [ [ "species_10479234", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10478098": { "compartment": "compartment_70101", "id": "reaction_10478098", "reactome": "R-DME-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10478095", "catalyst" ] ], "additional_components": [ "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043" ] }, "reaction_10440273": { "compartment": "compartment_70101", "id": "reaction_10440273", "reactome": "R-DME-193143", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_193057" ], "products": [ "species_193132", "species_29356", "species_29366", "species_29460" ], "modifiers": [ [ "species_10440256", "catalyst" ] ], "additional_components": [ "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395" ] }, "reaction_10496005": { "compartment": "compartment_7660", "id": "reaction_10496005", "reactome": "R-DME-9009282", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491664" ], "products": [ "species_113582", "species_10495911" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q24040", "FBgn0013753", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10492400": { "compartment": "compartment_7660", "id": "reaction_10492400", "reactome": "R-DME-8938356", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492396", "species_10491656" ], "products": [ "species_10492398" ], "modifiers": [], "additional_components": [ "FBgn0011640", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q94901", "FBgn0011640" ] }, "reaction_10491660": { "compartment": "compartment_7660", "id": "reaction_10491660", "reactome": "R-DME-8877902", "name": "Activated AR binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491656", "species_10473354" ], "products": [ "species_10491658" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10491668": { "compartment": "compartment_7660", "id": "reaction_10491668", "reactome": "R-DME-8877941", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491662", "species_10491664" ], "products": [ "species_10491666" ], "modifiers": [], "additional_components": [ "P42003", "FBgn0011648", "O62609", "FBgn0011655", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "P42003", "FBgn0011648", "O62609", "FBgn0011655" ] }, "reaction_10495959": { "compartment": "compartment_7660", "id": "reaction_10495959", "reactome": "R-DME-9008822", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10495951" ], "products": [ "species_113541", "species_10491664" ], "modifiers": [ [ "species_10495956", "catalyst" ] ], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "FBgn0022768" ] }, "reaction_10495914": { "compartment": "compartment_7660", "id": "reaction_10495914", "reactome": "R-DME-9008412", "name": "CDK4 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491664" ], "products": [ "species_113582", "species_10495911" ], "modifiers": [ [ "species_10493280", "catalyst" ] ], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q24040", "FBgn0013753", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10495757": { "compartment": "compartment_7660", "id": "reaction_10495757", "reactome": "R-DME-8985343", "name": "RUNX2 binds SOX9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474272", "species_10491656" ], "products": [ "species_10495755" ], "modifiers": [], "additional_components": [ "FBgn0024288", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VA17", "FBgn0024288" ] }, "reaction_10449051": { "compartment": "compartment_70101", "id": "reaction_10449051", "reactome": "R-DME-430021", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10449036" ], "products": [ "species_10449024", "species_76577" ], "modifiers": [ [ "species_10449048", "catalyst" ] ], "additional_components": [ "P21187", "FBgn0265297", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P21187", "FBgn0265297", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q95RR8", "FBgn0035397", "A1Z7K9", "FBgn0033352" ] }, "reaction_10493178": { "compartment": "compartment_70101", "id": "reaction_10493178", "reactome": "R-DME-8941312", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449024", "species_6782337" ], "products": [ "species_10493168" ], "modifiers": [ [ "species_10493173", "catalyst" ] ], "additional_components": [ "P21187", "FBgn0265297", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P21187", "FBgn0265297", "species_6782337", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0035889" ] }, "reaction_10488832": { "compartment": "compartment_70101", "id": "reaction_10488832", "reactome": "R-DME-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1221562" ], "products": [ "species_1221562", "species_10430300" ], "modifiers": [ [ "species_10488829", "catalyst" ] ], "additional_components": [ "P35122", "FBgn0010288", "Q9VYQ8", "FBgn0030366", "P55824", "FBgn0005632" ] }, "reaction_10488784": { "compartment": "compartment_7660", "id": "reaction_10488784", "reactome": "R-DME-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488611" ], "products": [ "species_164121", "species_10488710" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11" ] }, "reaction_10488771": { "compartment": "compartment_7660", "id": "reaction_10488771", "reactome": "R-DME-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488732", "species_10488712" ], "products": [ "species_10488611", "species_10488769" ], "modifiers": [], "additional_components": [ "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q9I7T6", "FBgn0035455", "Q9VQ00", "FBgn0031331", "Q9VYN3", "FBgn0030386", "Q7K738", "FBgn0026316", "Q9VUR4", "FBgn0036516", "Q9Y165", "FBgn0027609", "P25867", "eff", "A1Z8B5", "FBgn0033544", "P25153", "FBgn0004436", "Q9VX25", "FBgn0030863", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P25153", "FBgn0004436", "Q9VTY6", "FBgn0264848", "Q9I7T6", "FBgn0035455", "Q9VQ00", "FBgn0031331", "Q9VYN3", "FBgn0030386", "P52485", "FBgn0015320", "Q7K738", "FBgn0026316", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9VX25", "FBgn0030863", "A1Z8B5", "FBgn0033544", "Q9VUR4", "FBgn0036516" ] }, "reaction_10488836": { "compartment": "compartment_70101", "id": "reaction_10488836", "reactome": "R-DME-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488834" ], "products": [ "species_1221561", "species_10430729" ], "modifiers": [ [ "species_10488829", "catalyst" ] ], "additional_components": [ "P35122", "FBgn0010288", "Q9VYQ8", "FBgn0030366", "P55824", "FBgn0005632" ] }, "reaction_10488708": { "compartment": "compartment_70101", "id": "reaction_10488708", "reactome": "R-DME-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488649", "species_10488615" ], "products": [ "species_10488651", "species_10488706" ], "modifiers": [], "additional_components": [ "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "Q9VYN3", "FBgn0030386", "Q9VQ00", "FBgn0031331", "Q9I7T6", "FBgn0035455", "P52485", "FBgn0015320", "Q7JW03", "FBgn0029996", "Q7K738", "FBgn0026316", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q29R09", "FBgn0023528", "Q9VX25", "FBgn0030863", "Q9VXE8", "FBgn0267384", "P52486", "FBgn0015321", "Q8SYG3", "FBgn0058045", "Q9VUR4", "FBgn0036516", "Q9VTY6", "FBgn0264848", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "Q7JW03", "FBgn0029996", "Q9VTY6", "FBgn0264848", "P52486", "FBgn0015321", "Q7K738", "FBgn0026316", "Q9VQ00", "FBgn0031331", "Q9VYN3", "FBgn0030386", "P52485", "FBgn0015320", "Q9I7T6", "FBgn0035455", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q29R09", "FBgn0023528", "Q8SYG3", "FBgn0058045", "Q9VXE8", "FBgn0267384", "Q9VUR4", "FBgn0036516", "Q9VX25", "FBgn0030863", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10488613": { "compartment": "compartment_7660", "id": "reaction_10488613", "reactome": "R-DME-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427430", "species_10488565" ], "products": [ "species_113541", "species_10488611" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0023143", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488773": { "compartment": "compartment_7660", "id": "reaction_10488773", "reactome": "R-DME-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427430", "species_10488710" ], "products": [ "species_10488712", "species_113541" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488776": { "compartment": "compartment_70101", "id": "reaction_10488776", "reactome": "R-DME-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488617", "species_113592", "species_10426987" ], "products": [ "species_111294", "species_10488649" ], "modifiers": [ [ "species_10488617", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8T0L3", "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488841": { "compartment": "compartment_70101", "id": "reaction_10488841", "reactome": "R-DME-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488838" ], "products": [ "species_10426977", "species_10426979", "species_10426981", "species_10426983", "species_10426985", "species_10426969", "species_10426971", "species_10426973", "species_10426975" ], "modifiers": [ [ "species_10477601", "catalyst" ] ], "additional_components": [ "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0035402" ] }, "reaction_10488779": { "compartment": "compartment_70101", "id": "reaction_10488779", "reactome": "R-DME-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488651" ], "products": [ "species_10488617", "species_76577" ], "modifiers": [ [ "species_10488651", "catalyst" ] ], "additional_components": [ "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8T0L3", "FBgn0023143", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488845": { "compartment": "compartment_70101", "id": "reaction_10488845", "reactome": "R-DME-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488843" ], "products": [ "species_1221567", "species_1221557", "species_1221559" ], "modifiers": [ [ "species_10477601", "catalyst" ] ], "additional_components": [ "FBgn0035402" ] }, "reaction_10488782": { "compartment": "compartment_70101", "id": "reaction_10488782", "reactome": "R-DME-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457011", "species_113592", "species_10426987" ], "products": [ "species_111294", "species_10488651" ], "modifiers": [ [ "species_10457011", "catalyst" ] ], "additional_components": [ "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "FBgn0023143" ] }, "reaction_10495281": { "compartment": "compartment_7660", "id": "reaction_10495281", "reactome": "R-DME-8956659", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10458548" ], "products": [ "species_113582", "species_10495278" ], "modifiers": [ [ "species_10476652", "catalyst" ] ], "additional_components": [] }, "reaction_10495297": { "compartment": "compartment_70101", "id": "reaction_10495297", "reactome": "R-DME-8956684", "name": "ITCH polyubiquitinates TP73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495289", "species_10426987" ], "products": [ "species_10495294" ], "modifiers": [ [ "species_10456470", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8IMZ4", "FBgn0039044", "FBgn0003557" ] }, "reaction_10495299": { "compartment": "compartment_13231", "id": "reaction_10495299", "reactome": "R-DME-8957241", "name": "TP73 tetramer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495289" ], "products": [ "species_10481315" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10495269": { "compartment": "compartment_7660", "id": "reaction_10495269", "reactome": "R-DME-8956568", "name": "RUNX1 binds the core TAL1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489794", "species_10495265" ], "products": [ "species_10495267" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "P11420", "FBgn0267821", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "M9PI02", "FBgn0265598", "Q9W4X2", "FBgn0011276", "Q7KVG9", "FBgn0013764", "P11420", "FBgn0267821", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "M9PI02", "FBgn0265598", "Q9W4X2", "FBgn0011276", "Q7KVG9", "FBgn0013764", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10495285": { "compartment": "compartment_7660", "id": "reaction_10495285", "reactome": "R-DME-8956676", "name": "YAP1 binds TP73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495278", "species_10481315" ], "products": [ "species_10495283" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "Q45VV3", "yki" ] }, "reaction_10495301": { "compartment": "compartment_70101", "id": "reaction_10495301", "reactome": "R-DME-8957265", "name": "26S proteasome degrades TP73 polyubiquitinated by ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495294" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10489814": { "compartment": "compartment_7660", "id": "reaction_10489814", "reactome": "R-DME-8865482", "name": "KMT2A (MLL) binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489794", "species_10489810" ], "products": [ "species_10489812" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0003862", "P20659", "FBgn0003862", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10495274": { "compartment": "compartment_7660", "id": "reaction_10495274", "reactome": "R-DME-8956639", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10489794" ], "products": [ "species_10495272" ], "modifiers": [ [ "species_10476652", "inhibitor" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q45VV3", "yki" ] }, "reaction_10438764": { "compartment": "compartment_7660", "id": "reaction_10438764", "reactome": "R-DME-176973", "name": "Association of MCM8 with ORC:origin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426917", "species_10426938" ], "products": [ "species_10426942" ], "modifiers": [], "additional_components": [ "Q24168", "FBgn0015270", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "FBgn0003227", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181" ] }, "reaction_10427248": { "compartment": "compartment_7660", "id": "reaction_10427248", "reactome": "R-DME-68849", "name": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427210", "species_10427244" ], "products": [ "species_10427246" ], "modifiers": [], "additional_components": [ "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918" ] }, "reaction_10482653": { "compartment": "compartment_6799713", "id": "reaction_10482653", "reactome": "R-DME-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10482575" ], "products": [ "species_10482651" ], "modifiers": [], "additional_components": [ "O96692", "FBgn0283666", "Q9VMJ6", "FBgn0031760", "Q6NP91", "FBgn0033259", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "Q8IQC6", "FBgn0052039", "Q9VH76", "FBgn0266720", "P36975", "FBgn0011288", "Q86BK8", "FBgn0015791", "Q9VHG4", "FBgn0037671", "P45437", "FBgn0008635", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "P49283", "FBgn0011672", "P08646", "RAS85D", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "Q7KK97", "FBgn0028563", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q9VLT5", "FBgn0011230", "Q9VJW9", "FBgn0259984", "Q7YTY6", "FBgn0028988", "Q6QU65", "FBgn0265140", "X2JE21", "FBgn0259110", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9VS89", "FBgn0035798", "Q9VZA4", "FBgn0260657", "Q9NBC8", "FBgn0039595", "P12080", "FBgn0001250", "P23380", "FBgn0262736", "P09478", "FBgn0000036", "Q9VGD4", "FBgn0037989", "Q9W4F7", "FBgn0029737", "B7YZT5", "FBgn0286511", "M9PHI0", "FBgn0263220", "Q9VWE0", "dome", "Q9VWE0", "dome", "Q9W4F7", "FBgn0029737", "B7YZT5", "FBgn0286511", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9VMJ6", "FBgn0031760", "Q9VGD4", "FBgn0037989", "Q6NP91", "FBgn0033259", "P49283", "FBgn0011672", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "O96692", "FBgn0283666", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q86BK8", "FBgn0015791", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VLT5", "FBgn0011230", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9NBC8", "FBgn0039595", "Q9VZA4", "FBgn0260657", "Q7KK97", "FBgn0028563", "P23380", "FBgn0262736", "P09478", "FBgn0000036", "Q8IQC6", "FBgn0052039", "M9PHI0", "FBgn0263220", "Q9VJW9", "FBgn0259984", "Q7YTY6", "FBgn0028988", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "P08646", "RAS85D", "P45437", "FBgn0008635", "Q9VHG4", "FBgn0037671", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140", "P12080", "FBgn0001250" ] }, "reaction_10483433": { "compartment": "compartment_1462052", "id": "reaction_10483433", "reactome": "R-DME-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10483133" ], "products": [ "species_10483431" ], "modifiers": [], "additional_components": [ "Q9V3V6", "Rpt5", "Q9VDL0", "FBgn0038808", "P08736", "FBgn0284245", "P05303", "FBgn0000557", "Q9VHP0", "FBgn0263231", "Q7KN62", "FBgn0286784", "P13060", "FBgn0000559", "Q7JY94", "FBgn0034366", "B7Z0E0", "FBgn0001248", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710", "Q7JYW9", "FBgn0001187", "Q9W330", "FBgn0001186", "Q9VCZ5", "FBgn0038978", "Q24537", "Dsp1", "Q05783", "FBgn0004362", "E1JIT5", "FBgn0038979", "M9PE19", "FBgn0035348", "Q9W1K6", "FBgn0034898", "Q9VUJ1", "Prosbeta2", "O61443", "FBgn0024846", "P40301", "Prosalpha2", "Q95083", "Prosalpha5", "Q9VY39", "FBgn0030562", "Q8T3W8", "FBgn0037879", "Q9VT82", "FBgn0036070", "Q9VY19", "FBgn0020508", "Q9W2H4", "FBgn0034623", "Q8IRL3", "FBgn0052679", "Q9VI17", "FBgn0260766", "Q9VY18", "FBgn0015010", "Q9W2H3", "FBgn0034624", "Q8IND6", "FBgn0051296", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10483596" ], "products": [ "species_10483636" ], "modifiers": [], "additional_components": [ "O46037", "FBgn0004397", "Q94527", "Rel", "Q9W4K2", "FBgn0029708", "X2JAR4", "FBgn0261848", "Q7JQR3", "FBgn0033814", "Q8MM24", "FBgn0020416", "Q8MLZ7", "FBgn0020414", "Q23997", "FBgn0013763", "Q9W303", "FBgn0026415", "Q9VZV2", "FBgn0035398", "Q9V3D4", "FBgn0020415", "Q8T0R7", "FBgn0064237", "Q9VGN8", "FBgn0037900", "O76901", "FBgn0025382", "Q7KUC2", "FBgn0085484", "P29349", "FBgn0000382", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VE79", "FBgn0038611", "Q7K485", "FBgn0029093", "Q9VWZ7", "FBgn0030887", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q9VHE4", "FBgn0037687", "Q9VH14", "FBgn0025879", "Q7KRY7", "FBgn0263289", "Q9W122", "FBgn0035049", "Q9VJQ0", "FBgn0028888", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "A1Z9N6", "FBgn0261269", "Q9W0M1", "FBgn0035168", "P18824", "arm", "Q9VZI1", "FBgn0035499", "Q9VB21", "FBgn0039527", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "P13395", "FBgn0250789", "Q9VG73", "FBgn0038046", "O76895", "FBgn0023535", "O18388", "FBgn0262743", "Q9V9J3", "phospho-Src42A", "Q8IQM9", "FBgn0263607", "Q95TL8", "FBgn0030734", "Q86PD7", "FBgn0036999", "Q9VF87", "FBgn0038320", "Q7JQR3", "FBgn0033814", "Q95TL8", "FBgn0030734", "Q94527", "Rel", "Q9VH14", "FBgn0025879", "Q9VF87", "FBgn0038320", "Q23997", "FBgn0013763", "Q9W303", "FBgn0026415", "Q9VZV2", "FBgn0035398", "Q9V3D4", "FBgn0020415", "Q8T0R7", "FBgn0064237", "Q8MM24", "FBgn0020416", "Q8MLZ7", "FBgn0020414", "Q7KUC2", "FBgn0085484", "Q9VJQ0", "FBgn0028888", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "A1Z9N6", "FBgn0261269", "Q7K485", "FBgn0029093", "Q9W122", "FBgn0035049", "Q9VG73", "FBgn0038046", "Q8IQM9", "FBgn0263607", "X2JAR4", "FBgn0261848", "Q9VZI1", "FBgn0035499", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "P13395", "FBgn0250789", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "O46037", "FBgn0004397", "Q9VWZ7", "FBgn0030887", "Q9VE79", "FBgn0038611", "Q9VHE4", "FBgn0037687", "Q9W4K2", "FBgn0029708", "Q9V9J3", "phospho-Src42A", "O76895", "FBgn0023535", "P29349", "FBgn0000382", "Q9VB21", "FBgn0039527", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "P18824", "arm", "Q9W0M1", "FBgn0035168", "O76901", "FBgn0025382", "Q9VGN8", "FBgn0037900", "Q7KRY7", "FBgn0263289", "Q86PD7", "FBgn0036999", "O18388", "FBgn0262743" ] }, "reaction_10484598": { "compartment": "compartment_6799351", "id": "reaction_10484598", "reactome": "R-DME-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484554" ], "products": [ "species_10484596" ], "modifiers": [], "additional_components": [ "Q9W179", "FBgn0035001", "Q9VIG0", "FBgn0032916", "Q9VYJ4", "FBgn0030421", "O62531", "FBgn0024833", "Q9VXM4", "FBgn0030703", "B7YZF8", "FBgn0259221", "P09478", "FBgn0000036", "Q9VGD4", "FBgn0037989", "M9PHI0", "FBgn0263220", "P12080", "FBgn0001250", "Q9VWE0", "dome", "Q9VXG0", "FBgn0030752", "O96692", "FBgn0283666", "Q94515", "FBgn0001941", "Q9VW73", "FBgn0036932", "B7YZT5", "FBgn0286511", "Q9VMJ6", "FBgn0031760", "Q9VAP3", "FBgn0039637", "Q6NP91", "FBgn0033259", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999", "Q9VH76", "FBgn0266720", "P36975", "FBgn0011288", "Q8IRI6", "FBgn0264574", "E1JI63", "FBgn0035815", "Q9NBC8", "FBgn0039595", "A1Z7G7", "FBgn0033313", "Q9VA10", "FBgn0039821", "Q8SZ78", "FBgn0039818", "Q9VGJ9", "FBgn0037933", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "Q9VXD1", "FBgn0261245", "Q9W4B6", "FBgn0029771", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9VLT5", "FBgn0011230", "P35992", "FBgn0004370", "Q960U8", "FBgn0004797", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "Q9VJW9", "FBgn0259984", "Q8MPP3", "FBgn0033438", "P08645", "FBgn0004636", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140", "Q9VZA4", "FBgn0260657", "Q9VXV6", "FBgn0040285", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9V7D2", "FBgn0022097", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "Q7KK97", "FBgn0028563", "Q9W4F7", "FBgn0029737", "Q9V8I2", "FBgn0034350", "Q9VJD2", "FBgn0032642", "Q9VSZ1", "FBgn0035995", "Q8SY02", "FBgn0051634", "Q03751", "FBgn0004179", "Q9VP04", "FBgn0037110", "M9PBR6", "FBgn0053523", "A1Z7G7", "FBgn0033313", "Q9VA10", "FBgn0039821", "Q8SZ78", "FBgn0039818", "Q9VGJ9", "FBgn0037933", "M9PBR6", "FBgn0053523", "E1JI63", "FBgn0035815", "Q9VIG0", "FBgn0032916", "Q8IRI6", "FBgn0264574", "Q9VXM4", "FBgn0030703", "Q9W179", "FBgn0035001", "Q9V7D2", "FBgn0022097", "Q9VXV6", "FBgn0040285", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "P12080", "FBgn0001250", "Q8SY02", "FBgn0051634", "Q9VSZ1", "FBgn0035995", "P09478", "FBgn0000036", "Q9W4B6", "FBgn0029771", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "Q9VXD1", "FBgn0261245", "Q9VYJ4", "FBgn0030421", "Q9NBC8", "FBgn0039595", "O62531", "FBgn0024833", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "Q94515", "FBgn0001941", "Q9VLT5", "FBgn0011230", "Q960U8", "FBgn0004797", "P35992", "FBgn0004370", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q9VGD4", "FBgn0037989", "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "B7YZT5", "FBgn0286511", "Q03751", "FBgn0004179", "Q9VP04", "FBgn0037110", "B7YZF8", "FBgn0259221", "Q9VJW9", "FBgn0259984", "M9PHI0", "FBgn0263220", "Q9VXG0", "FBgn0030752", "Q9VW73", "FBgn0036932", "Q7KK97", "FBgn0028563", "Q9VZA4", "FBgn0260657", "Q8MPP3", "FBgn0033438", "Q9VAP3", "FBgn0039637", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9V8I2", "FBgn0034350", "Q9VJD2", "FBgn0032642", "O96692", "FBgn0283666", "Q6NP91", "FBgn0033259", "Q9VMJ6", "FBgn0031760", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9W4F7", "FBgn0029737", "Q9VWE0", "dome", "P08645", "FBgn0004636", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140" ] }, "reaction_10481684": { "compartment": "compartment_6798757", "id": "reaction_10481684", "reactome": "R-DME-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481590" ], "products": [ "species_10481682" ], "modifiers": [], "additional_components": [ "Q9VXG0", "FBgn0030752", "Q9VIM0", "FBgn0032864", "Q9VXD1", "FBgn0261245", "Q9W4B6", "FBgn0029771", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "P23380", "FBgn0262736", "Q9VSZ1", "FBgn0035995", "O02194", "FBgn0284421", "Q8SY02", "FBgn0051634", "Q9W1I8", "FBgn0034913", "Q9VC27", "FBgn0039234", "Q9VQM2", "FBgn0031505", "Q7JYV2", "FBgn0033876", "Q8SY19", "FBgn0025814", "Q8SY53", "FBgn0032015", "A1Z959", "FBgn0050486", "Q9VHJ0", "FBgn0037650", "Q8IRK1", "FBgn0264297", "Q9W129", "FBgn0035042", "A8WHB7", "FBgn0054049", "Q9VIN6", "FBgn0032853", "O18405", "FBgn0019925", "Q9VLH1", "FBgn0032074", "Q9V3I2", "FBgn0014010", "Q9V9S0", "FBgn0032949", "P25228", "FBgn0005586", "Q9VZP9", "FBgn0035444", "Q9VD68", "FBgn0038912", "Q9VW01", "FBgn0036877", "Q8I0P9", "FBgn0000032", "Q9VW00", "FBgn0036876", "B7Z080", "FBgn0036875", "Q9VQ86", "FBgn0031397", "Q9VMY5", "FBgn0037215", "Q7KN92", "FBgn0027538", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "P08645", "FBgn0004636", "Q9VHV5", "FBgn0037551", "Q0KHU5", "FBgn0052699", "B7YZF8", "FBgn0259221", "Q24319", "FBgn0014868", "Q9VZA4", "FBgn0260657", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q03751", "FBgn0004179", "A1Z7S0", "FBgn0015477", "Q9VW73", "FBgn0036932", "Q9Y125", "FBgn0000416", "Q03751", "FBgn0004179", "Q9VQM2", "FBgn0031505", "Q8SY19", "FBgn0025814", "A1Z959", "FBgn0050486", "Q9W129", "FBgn0035042", "Q9VIN6", "FBgn0032853", "Q9VHJ0", "FBgn0037650", "Q8IRK1", "FBgn0264297", "A8WHB7", "FBgn0054049", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "A1Z7S0", "FBgn0015477", "Q24319", "FBgn0014868", "Q9VZA4", "FBgn0260657", "Q9W4B6", "FBgn0029771", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "Q9VXD1", "FBgn0261245", "Q9VW73", "FBgn0036932", "Q9VLH1", "FBgn0032074", "Q9VHV5", "FBgn0037551", "Q9VXG0", "FBgn0030752", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "O02194", "FBgn0284421", "P23380", "FBgn0262736", "Q9VMY5", "FBgn0037215", "Q9VSZ1", "FBgn0035995", "Q0KHU5", "FBgn0052699", "Q7JYV2", "FBgn0033876", "Q9V9S0", "FBgn0032949", "Q9W1I8", "FBgn0034913", "Q9VZP9", "FBgn0035444", "Q8SY02", "FBgn0051634", "O18405", "FBgn0019925", "Q9V3I2", "FBgn0014010", "P25228", "FBgn0005586", "Q9VC27", "FBgn0039234", "Q9Y125", "FBgn0000416", "Q9VIM0", "FBgn0032864", "B7YZF8", "FBgn0259221", "Q8SY53", "FBgn0032015", "Q9VW01", "FBgn0036877", "Q9VW00", "FBgn0036876", "Q9VQ86", "FBgn0031397", "Q9VD68", "FBgn0038912", "Q8I0P9", "FBgn0000032", "B7Z080", "FBgn0036875", "P08645", "FBgn0004636", "Q7KN92", "FBgn0027538" ] }, "reaction_10484242": { "compartment": "compartment_1470028", "id": "reaction_10484242", "reactome": "R-DME-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484040" ], "products": [ "species_10484240" ], "modifiers": [], "additional_components": [ "A1Z8C9", "FBgn0050016", "Q9VQX4", "FBgn0031589", "Q7KN62", "FBgn0286784", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630", "Q9W3C4", "FBgn0041629", "Q8IQM9", "FBgn0263607", "Q7JYA0", "FBgn0033873", "Q9VWE8", "FBgn0031050", "Q9VRP2", "FBgn0035630", "Q9V420", "FBgn0004465", "Q9VEK7", "FBgn0025456", "P83099", "FBgn0259680", "A1ZBX7", "FBgn0034539", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9VQI7", "FBgn0031479", "Q9VS41", 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homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10482267" ], "products": [ "species_10482367" ], "modifiers": [], "additional_components": [ "Q9VH14", "FBgn0025879", "P13395", "FBgn0250789", "Q9VTP0", "FBgn0259140", "Q9VHE4", "FBgn0037687", "Q9VZI1", "FBgn0035499", "Q9V3D4", "FBgn0020415", "Q8T0R7", "FBgn0064237", "Q8MM24", "FBgn0020416", "Q8MLZ7", "FBgn0020414", "Q23997", "FBgn0013763", "Q9W303", "FBgn0026415", "Q9VZV2", "FBgn0035398", "Q9VJ39", "FBgn0032721", "Q9VWZ7", "FBgn0030887", "Q9VUY9", "FBgn0003076", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9VYH1", "FBgn0030449", "X2JAR4", "FBgn0261848", "Q9VU84", "FBgn0036372", "Q9VLR3", "FBgn0032001", "P29349", "FBgn0000382", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q8IQM9", "FBgn0263607", "Q9VGN8", "FBgn0037900", "Q9VG73", "FBgn0038046", "Q7JQR3", "FBgn0033814", "Q9VNK6", "FBgn0037396", "Q9W4K2", "FBgn0029708", "Q7K485", "FBgn0029093", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "Q9VJQ0", "FBgn0028888", "A1Z9N6", "FBgn0261269", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "Q9XZF0", "FBgn0026749", "Q9W122", "FBgn0035049", "Q86PD7", "FBgn0036999", "B7Z0E0", "FBgn0001248", "Q9VF87", "FBgn0038320", "B7Z0E0", "FBgn0001248", "Q7JQR3", "FBgn0033814", "Q9VF87", "FBgn0038320", "Q9VH14", "FBgn0025879", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q9VYH1", "FBgn0030449", "Q9VU84", "FBgn0036372", "Q9VNK6", "FBgn0037396", "Q9VLR3", "FBgn0032001", "Q9VJQ0", "FBgn0028888", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "A1Z9N6", "FBgn0261269", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9W122", "FBgn0035049", "Q7K485", "FBgn0029093", "Q9VG73", "FBgn0038046", "Q8IQM9", "FBgn0263607", "X2JAR4", "FBgn0261848", "Q9VZI1", "FBgn0035499", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VTP0", "FBgn0259140", "Q9VUY9", "FBgn0003076", "Q9VJ39", "FBgn0032721", "P13395", "FBgn0250789", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "Q9VWZ7", "FBgn0030887", "Q9VHE4", "FBgn0037687", "Q9W4K2", "FBgn0029708", "Q9XZF0", "FBgn0026749", "P29349", "FBgn0000382", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "Q9VGN8", "FBgn0037900", "Q86PD7", "FBgn0036999", "Q8T0R7", "FBgn0064237", "Q9W303", "FBgn0026415", "Q8MM24", "FBgn0020416", "Q9VZV2", "FBgn0035398", "Q8MLZ7", "FBgn0020414", "Q9V3D4", "FBgn0020415", "Q23997", "FBgn0013763" ] }, "reaction_10485728": { "compartment": "compartment_984", "id": "reaction_10485728", "reactome": "R-DME-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485116" ], "products": [ "species_10485198" ], "modifiers": [], "additional_components": [ "Q9VIM0", "FBgn0032864", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "P23380", "FBgn0262736", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "P49283", "FBgn0011672", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P55162", "FBgn0011771", "Q9VHM2", "FBgn0037622", "Q9VLT5", "FBgn0011230", "Q9VLL4", 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"FBgn0259110", "Q6QU65", "FBgn0265140" ] }, "reaction_10482080": { "compartment": "compartment_876", "id": "reaction_10482080", "reactome": "R-DME-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481912" ], "products": [ "species_10482078" ], "modifiers": [], "additional_components": [ "O18334", "Rab6", "Q7KK97", "FBgn0028563", "Q9XZ10", "FBgn0028671", "Q8IQC6", "FBgn0052039", "Q9VEX6", "FBgn0287225", "Q9V3I2", "FBgn0014010", "Q7KY04", "FBgn0016701", "P91926", "FBgn0264855", "Q7KN92", "FBgn0027538", "A1Z7S0", "FBgn0015477", "P25228", "FBgn0005586", "Q9VP04", "FBgn0037110", "Q9W4A0", "FBgn0015794", "P45437", "FBgn0008635", "O15971", "FBgn0015789", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "P40792", "RAC1_DROME", "Q9VIW6", "FBgn0032782", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VPH1", "FBgn0036978", "Q9VPU6", "FBgn0031289", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "P55162", "FBgn0011771", "Q7KRW4", "FBgn0039640", "Q9VLL4", "FBgn0032042", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "P48608", "FBgn0011202", "Q9VZ20", "FBgn0030276", "Q9W5Y0", "FBgn0031081", "P12080", "FBgn0001250", "P48148", "Rho1", "Q09101", "FBgn0010114", "Q9VYR4", "FBgn0001083", "O76742", "FBgn0015795", "Q9W5Y0", "FBgn0031081", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q7KRW4", "FBgn0039640", "P48148", "Rho1", "P25228", "FBgn0005586", "O76742", "FBgn0015795", "O18334", "Rab6", "P91926", "FBgn0264855", "A1Z7S0", "FBgn0015477", "Q9V3I2", "FBgn0014010", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q7KY04", "FBgn0016701", "Q7KK97", "FBgn0028563", "Q9W4A0", "FBgn0015794", "O15971", "FBgn0015789", "Q9VIW6", "FBgn0032782", "Q9VPH1", "FBgn0036978", "Q9VPU6", "FBgn0031289", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q8IQC6", "FBgn0052039", "P55162", "FBgn0011771", "Q9VLL4", "FBgn0032042", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "P48608", "FBgn0011202", "Q9VZ20", "FBgn0030276", "Q9XZ10", "FBgn0028671", "Q9VEX6", "FBgn0287225", "Q9VP04", "FBgn0037110", "P12080", "FBgn0001250", "P45437", "FBgn0008635", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "P40792", "RAC1_DROME", "Q7KN92", "FBgn0027538" ] }, "reaction_10493472": { "compartment": "compartment_70101", "id": "reaction_10493472", "reactome": "R-DME-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493467", "species_113592" ], "products": [ "species_10493470", "species_29370" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10493490": { "compartment": "compartment_70101", "id": "reaction_10493490", "reactome": "R-DME-8948143", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493470", "species_113592" ], "products": [ "species_10493487", "species_29370" ], "modifiers": [ [ "species_10440003", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "FBgn0262733" ] }, "reaction_10493476": { "compartment": "compartment_17906", "id": "reaction_10493476", "reactome": "R-DME-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475486" ], "products": [ "species_10493474" ], "modifiers": [], "additional_components": [ "FBgn0260945", "FBgn0260945" ] }, "reaction_10493496": { "compartment": "compartment_17906", "id": "reaction_10493496", "reactome": "R-DME-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493467", "species_113592" ], "products": [ "species_29370", "species_10493493" ], "modifiers": [ [ "species_10493474", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "FBgn0260945" ] }, "reaction_10493484": { "compartment": "compartment_70101", "id": "reaction_10493484", "reactome": "R-DME-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493470" ], "products": [ "species_10493467" ], "modifiers": [ [ "species_10493481", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "FBgn0023517" ] }, "reaction_10470847": { "compartment": "compartment_17906", "id": "reaction_10470847", "reactome": "R-DME-5205682", "name": "Parkin promotes the ubiquitination of mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457377", "species_10457379", "species_10470842", "species_10426987", "species_10470844" ], "products": [ "species_10470752", "species_10470784", "species_10470758", "species_10470745" ], "modifiers": [ [ "species_10470798", "catalyst" ] ], "additional_components": [ "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "FBgn0029870", "Q9VKP4", "FBgn0260453", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q94920", "FBgn0004363", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0037008", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "FBgn0037008", "FBgn0029870", "Q0KHV6", "FBgn0029891", "Q7KTX7", "FBgn0041100" ] }, "reaction_10470828": { "compartment": "compartment_70101", "id": "reaction_10470828", "reactome": "R-DME-5205673", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470784", "species_10470752", "species_10470789", "species_10470758", "species_10470745" ], "products": [ "species_10470791" ], "modifiers": [], "additional_components": [ "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "FBgn0003231", "FBgn0037008", "FBgn0029870", "Q7YU24", "FBgn0029870", "Q9VPD5", "FBgn0037008", "P14199", "FBgn0003231", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354" ] }, "reaction_10470826": { "compartment": "compartment_17906", "id": "reaction_10470826", "reactome": "R-DME-5205672", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470804" ], "products": [ "species_10470796" ], "modifiers": [], "additional_components": [ "FBgn0029891", "FBgn0029891" ] }, "reaction_10470824": { "compartment": "compartment_21994", "id": "reaction_10470824", "reactome": "R-DME-5205663", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470816", "species_10470820" ], "products": [ "species_10470822" ], "modifiers": [], "additional_components": [ "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "Q7YU24", "FBgn0029870", "Q9VPD5", "FBgn0037008", "P14199", "FBgn0003231", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q7YU24", "FBgn0029870", "Q9VPD5", "FBgn0037008", "P14199", "FBgn0003231", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255" ] }, "reaction_10470832": { "compartment": "compartment_17927", "id": "reaction_10470832", "reactome": "R-DME-5205681", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470804" ], "products": [ "species_10470830" ], "modifiers": [], "additional_components": [ "FBgn0029891", "FBgn0029891" ] }, "reaction_10470800": { "compartment": "compartment_17906", "id": "reaction_10470800", "reactome": "R-DME-5205652", "name": "Pink1 recruits Parkin to the outer mitochondrial membrane.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456711", "species_10470796" ], "products": [ "species_10470798" ], "modifiers": [], "additional_components": [ "FBgn0041100", "FBgn0029891", "Q0KHV6", "FBgn0029891", "Q7KTX7", "FBgn0041100" ] }, "reaction_10498066": { "compartment": "compartment_70101", "id": "reaction_10498066", "reactome": "R-DME-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498064" ], "products": [ "species_10498062", "species_10498041" ], "modifiers": [], "additional_components": [ "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10498039": { "compartment": "compartment_70101", "id": "reaction_10498039", "reactome": "R-DME-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498013", "species_10498035" ], "products": [ "species_10498037" ], "modifiers": [], "additional_components": [ "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10498122": { "compartment": "compartment_70101", "id": "reaction_10498122", "reactome": "R-DME-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498118", "species_10473486" ], "products": [ "species_10498120" ], "modifiers": [], "additional_components": [ "M9PJN5", "FBgn0026428", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "M9PJN5", "FBgn0026428", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802" ] }, "reaction_10498091": { "compartment": "compartment_70101", "id": "reaction_10498091", "reactome": "R-DME-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498037" ], "products": [ "species_10498089" ], "modifiers": [], "additional_components": [ "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q400N2", "FBgn0086690", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q9VA37", "FBgn0039802", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10498093": { "compartment": "compartment_70101", "id": "reaction_10498093", "reactome": "R-DME-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498089" ], "products": [ "species_10498064" ], "modifiers": [], "additional_components": [ "Q400N2", "FBgn0086690", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q9VA37", "FBgn0039802", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802" ] }, "reaction_10498015": { "compartment": "compartment_70101", "id": "reaction_10498015", "reactome": "R-DME-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498011", "species_10456711" ], "products": [ "species_10498013" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "FBgn0041100", "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10476379": { "compartment": "compartment_70101", "id": "reaction_10476379", "reactome": "R-DME-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476267" ], "products": [ "species_10476252", "species_10476207" ], "modifiers": [], "additional_components": [ "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539" ] }, "reaction_10476250": { "compartment": "compartment_70101", "id": "reaction_10476250", "reactome": "R-DME-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460755" ], "products": [ "species_10476237" ], "modifiers": [], "additional_components": [ "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325" ] }, "reaction_10476377": { "compartment": "compartment_70101", "id": "reaction_10476377", "reactome": "R-DME-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476211", "species_10476263" ], "products": [ "species_10476265" ], "modifiers": [], "additional_components": [ "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813" ] }, "reaction_10476248": { "compartment": "compartment_70101", "id": "reaction_10476248", "reactome": "R-DME-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476225", "species_10476227" ], "products": [ "species_10476229" ], "modifiers": [], "additional_components": [ "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "B7Z0R7", "FBgn0039705", "species_1806289", "M9PER1", "FBgn0035850", "species_1806289", "M9PER1", "FBgn0035850", "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "B7Z0R7", "FBgn0039705" ] }, "reaction_10476246": { "compartment": "compartment_70101", "id": "reaction_10476246", "reactome": "R-DME-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476100" ], "products": [ "species_10460794" ], "modifiers": [], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960", "Q7KTS2", "FBgn0037363", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10476244": { "compartment": "compartment_70101", "id": "reaction_10476244", "reactome": "R-DME-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10476241", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "A1ZAS8", "FBgn0027506" ] }, "reaction_10475727": { "compartment": "compartment_70101", "id": "reaction_10475727", "reactome": "R-DME-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040", "species_10475494" ], "products": [ "species_10475696" ], "modifiers": [], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10476239": { "compartment": "compartment_70101", "id": "reaction_10476239", "reactome": "R-DME-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10476237" ], "products": [ "species_10475715", "species_29370" ], "modifiers": [ [ "species_10460794", "catalyst" ] ], "additional_components": [ "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475724": { "compartment": "compartment_17938", "id": "reaction_10475724", "reactome": "R-DME-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040" ], "products": [ "species_10445903" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10475722", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198" ] }, "reaction_10476299": { "compartment": "compartment_70101", "id": "reaction_10476299", "reactome": "R-DME-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476199", "species_10476252" ], "products": [ "species_10476263" ], "modifiers": [], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366" ] }, "reaction_10476297": { "compartment": "compartment_70101", "id": "reaction_10476297", "reactome": "R-DME-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476278" ], "products": [ "species_10476199" ], "modifiers": [ [ "species_10476294", "catalyst" ] ], "additional_components": [ "Q9VEG5", "FBgn0038539", "Q9W2S2", "FBgn0052672", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q9VPW2", "FBgn0031298" ] }, "reaction_10476232": { "compartment": "compartment_70101", "id": "reaction_10476232", "reactome": "R-DME-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5681998", "species_10476207" ], "products": [ "species_10476209", "species_10476211" ], "modifiers": [ [ "species_10476229", "catalyst" ] ], "additional_components": [ "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "species_1602375", "FBgn0036813", "species_1806289", "M9PER1", "FBgn0035850", "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "B7Z0R7", "FBgn0039705" ] }, "reaction_10476103": { "compartment": "compartment_70101", "id": "reaction_10476103", "reactome": "R-DME-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475691" ], "products": [ "species_10476100", "species_29370" ], "modifiers": [ [ "species_10475691", "catalyst" ] ], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960", "Q7KTS2", "FBgn0037363", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475718": { "compartment": "compartment_12045", "id": "reaction_10475718", "reactome": "R-DME-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_5676030" ], "modifiers": [ [ "species_10475715", "catalyst" ] ], "additional_components": [ "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325" ] }, "reaction_10460797": { "compartment": "compartment_70101", "id": "reaction_10460797", "reactome": "R-DME-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460757", "species_113592" ], "products": [ "species_29370", "species_10460763" ], "modifiers": [ [ "species_10460794", "catalyst" ] ], "additional_components": [ "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475708": { "compartment": "compartment_70101", "id": "reaction_10475708", "reactome": "R-DME-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475494", "species_10445887" ], "products": [ "species_10475496" ], "modifiers": [], "additional_components": [ "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10476091": { "compartment": "compartment_74700", "id": "reaction_10476091", "reactome": "R-DME-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475946" ], "products": [ "species_10475701", "species_10437109" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691" ] }, "reaction_10476347": { "compartment": "compartment_5683628", "id": "reaction_10476347", "reactome": "R-DME-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476209" ], "products": [ "species_10476338" ], "modifiers": [ [ "species_10476345", "catalyst" ], [ "species_10454980", "catalyst" ] ], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "species_1602375", "species_1602375", "Q9VEG5", "FBgn0038539", "Q9W2S2", "FBgn0052672", "Q9W1M7", "FBgn0015277", "Q9VK07", "FBgn0032499", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10475706": { "compartment": "compartment_17938", "id": "reaction_10475706", "reactome": "R-DME-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475696", "species_113592" ], "products": [ "species_29370", "species_10475703" ], "modifiers": [ [ "species_10475696", "catalyst" ] ], "additional_components": [ "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10476407": { "compartment": "compartment_70101", "id": "reaction_10476407", "reactome": "R-DME-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475701" ], "products": [ "species_29372", "species_10475494" ], "modifiers": [], "additional_components": [ "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475505": { "compartment": "compartment_70101", "id": "reaction_10475505", "reactome": "R-DME-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475496" ], "products": [ "species_29370", "species_10475502" ], "modifiers": [ [ "species_10475496", "catalyst" ] ], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475694": { "compartment": "compartment_70101", "id": "reaction_10475694", "reactome": "R-DME-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475502" ], "products": [ "species_29370", "species_10475691" ], "modifiers": [ [ "species_10475502", "catalyst" ] ], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10476270": { "compartment": "compartment_70101", "id": "reaction_10476270", "reactome": "R-DME-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476265" ], "products": [ "species_10476267" ], "modifiers": [ [ "species_10476265", "catalyst" ] ], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813", "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813" ] }, "reaction_10475948": { "compartment": "compartment_70101", "id": "reaction_10475948", "reactome": "R-DME-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475703" ], "products": [ "species_29370", "species_10475946" ], "modifiers": [ [ "species_10445887", "catalyst" ] ], "additional_components": [ "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10496854": { "compartment": "compartment_70101", "id": "reaction_10496854", "reactome": "R-DME-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476254" ], "products": [ "species_10476375" ], "modifiers": [], "additional_components": [ "Q7JY94", "FBgn0034366", "Q9VTU1", "FBgn0036255", "Q9VTU1", "FBgn0036255", "Q7JY94", "FBgn0034366" ] }, "reaction_10476328": { "compartment": "compartment_12045", "id": "reaction_10476328", "reactome": "R-DME-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475715" ], "products": [ "species_10476326" ], "modifiers": [], "additional_components": [ "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325" ] }, "reaction_10476322": { "compartment": "compartment_70101", "id": "reaction_10476322", "reactome": "R-DME-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476209" ], "products": [ "species_5681998", "species_10476199" ], "modifiers": [ [ "species_10476294", "catalyst" ] ], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "species_1602375", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q9VPW2", "FBgn0031298" ] }, "reaction_10476128": { "compartment": "compartment_70101", "id": "reaction_10476128", "reactome": "R-DME-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693050", "species_10476124" ], "products": [ "species_10476126" ], "modifiers": [], "additional_components": [ "M9PER1", "FBgn0035850", "Q9VIE1", "FBgn0032935", "M9PER1", "FBgn0035850", "Q9VIE1", "FBgn0032935", "species_1806198" ] }, "reaction_10476256": { "compartment": "compartment_70101", "id": "reaction_10476256", "reactome": "R-DME-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476218", "species_10476252" ], "products": [ "species_10476254" ], "modifiers": [], "additional_components": [ "FBgn0036255", "Q7JY94", "FBgn0034366", "Q7JY94", "FBgn0034366", "Q9VTU1", "FBgn0036255" ] }, "reaction_350436": { "compartment": "compartment_70101", "id": "reaction_350436", "reactome": "R-DME-350436", "name": "DGO binds to DSH", "reversible": "false", "notes": "Diego (DGO) binding to Dishevelled (DSH) enhances Frizzled (FZ) PCP signalling. DGO, like FZ is required in R3/Distal cell fate. DGO binds to PDZ domain of DSH. DGO binding to DSH protects it from (Prickle) PK binding and its antagonistic effects. DGO could help promote DSH activation via stimulation of its phosphorylation.", "reactants": [ "species_450795", "species_351073" ], "products": [ "species_450734" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK" ] }, "reaction_350486": { "compartment": "compartment_70101", "id": "reaction_350486", "reactome": "R-DME-350486", "name": "DSH binds to FZ at the plasma membrane", "reversible": "false", "notes": "In the cytosol, the PDZ domain of Dishevelled (DSH) binds to the transmembrane receptor Frizzled (FZ) at the plasma membrane.", "reactants": [ "species_450698", "species_205749" ], "products": [ "species_450779" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "Q9V5N8", "STAN", "P18537", "FZ", "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ" ] }, "reaction_350408": { "compartment": "compartment_70101", "id": "reaction_350408", "reactome": "R-DME-350408", "name": "PK binds to VANG at the plasma membrane", "reversible": "false", "notes": "C-terminal region of Vang Gogh (VANG) binds to a C-terminal region of Prickle (PK). Both VANG and PK are both able to bind to themselves in the same regions.", "reactants": [ "species_351050", "species_450779" ], "products": [ "species_450795" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK" ] }, "reaction_10493702": { "compartment": "compartment_7660", "id": "reaction_10493702", "reactome": "R-DME-8951676", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464533", "species_10489801" ], "products": [ "species_10493700" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd", "FBgn0083981", "M9PI08", "FBgn0083981", "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_390133": { "compartment": "compartment_13231", "id": "reaction_390133", "reactome": "R-DME-390133", "name": "YKI transports from the cytosol to the nucleus", "reversible": "false", "notes": "The transcription factor Yorkie (YKI) translocates from the cytosol to the nucleus.", "reactants": [ "species_390114" ], "products": [ "species_390143" ], "modifiers": [], "additional_components": [] }, "reaction_390184": { "compartment": "compartment_7660", "id": "reaction_390184", "reactome": "R-DME-390184", "name": "YKI binds to SD and activates transcription", "reversible": "false", "notes": "The transcriptional factor Yorkie (YKI) forms a transcriptional activation complex for its target genes with Scalloped (SD).", "reactants": [ "species_390187", "species_390143" ], "products": [ "species_390092" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_451819": { "compartment": "compartment_7660", "id": "reaction_451819", "reactome": "R-DME-451819", "name": "YKI binds to HTH and TSH and activates transcription", "reversible": "false", "notes": "Yorkie (YKI) binds to the DNA-binding transcription factor, Homothorax (HTH). HTH in conjunction with the DNA-binding transcription factor, Teashirt (TSH) regulate the YKI target gene for the microRNA bantam (ban). HTH and YKI are both bound to the same region of the bantam locus in eye discs. This suggests that YKI, HTH, and TSH form a DNA-binding complex which activates transcription for the bantam target gene.", "reactants": [ "species_451881", "species_451832", "species_390143" ], "products": [ "species_451887" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P22265", "TSH", "O46339", "HTH" ] }, "reaction_10436586": { "compartment": "compartment_5460", "id": "reaction_10436586", "reactome": "R-DME-163320", "name": "Association of mTERF with the termination sequence", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164569", "species_10436582" ], "products": [ "species_10436584" ], "modifiers": [], "additional_components": [ "FBgn0028530", "Q9V3F3", "FBgn0028530" ] }, "reaction_10432638": { "compartment": "compartment_7660", "id": "reaction_10432638", "reactome": "R-DME-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10432467" ], "products": [ "species_113550", "species_113582", "species_10432459" ], "modifiers": [ [ "species_10431174", "catalyst" ] ], "additional_components": [ "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10432479": { "compartment": "compartment_7660", "id": "reaction_10432479", "reactome": "R-DME-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432427", "species_30595" ], "products": [ "species_10431322", "species_113541", "species_10432477" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10432430": { "compartment": "compartment_7660", "id": "reaction_10432430", "reactome": "R-DME-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431434", "species_30595" ], "products": [ "species_113541", "species_10432427" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10432494": { "compartment": "compartment_7660", "id": "reaction_10432494", "reactome": "R-DME-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10432477" ], "products": [ "species_10431317", "species_10431432", "species_113541", "species_10431420", "species_10432492" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10434104": { "compartment": "compartment_7660", "id": "reaction_10434104", "reactome": "R-DME-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433060", "species_30595" ], "products": [ "species_10433097", "species_113541" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10497528": { "compartment": "compartment_7660", "id": "reaction_10497528", "reactome": "R-DME-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10432427" ], "products": [ "species_164121", "species_113541", "species_10432427" ], "modifiers": [ [ "species_10431174", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10433062": { "compartment": "compartment_7660", "id": "reaction_10433062", "reactome": "R-DME-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10432492" ], "products": [ "species_10433060", "species_113541" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10497530": { "compartment": "compartment_7660", "id": "reaction_10497530", "reactome": "R-DME-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431434", "species_30595" ], "products": [ "species_10431434", "species_113541" ], "modifiers": [ [ "species_10431174", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10434782": { "compartment": "compartment_7660", "id": "reaction_10434782", "reactome": "R-DME-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10434765" ], "products": [ "species_10431174", "species_10434780" ], "modifiers": [], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P20232", "FBgn0010422", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q7JRJ1", "FBgn0033166", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "A8JV07", "FBgn0030738", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434796": { "compartment": "compartment_7660", "id": "reaction_10434796", "reactome": "R-DME-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434792" ], "products": [ "species_10434794" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434818": { "compartment": "compartment_7660", "id": "reaction_10434818", "reactome": "R-DME-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10434780" ], "products": [ "species_10434792", "species_30595" ], "modifiers": [], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "species_110577", "species_113592", "species_29494", "species_29438" ] }, "reaction_10492379": { "compartment": "compartment_161320", "id": "reaction_10492379", "reactome": "R-DME-8938108", "name": "SERPINB13 binds cathepsin L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492375", "species_10492373" ], "products": [ "species_10492377" ], "modifiers": [], "additional_components": [ "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229" ] }, "reaction_10492383": { "compartment": "compartment_161320", "id": "reaction_10492383", "reactome": "R-DME-8938121", "name": "SERPINB13 binds CTSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492373", "species_10465003" ], "products": [ "species_10492381" ], "modifiers": [], "additional_components": [ "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293" ] }, "reaction_10492387": { "compartment": "compartment_7660", "id": "reaction_10492387", "reactome": "R-DME-8938217", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467716", "species_10489794" ], "products": [ "species_10492385" ], "modifiers": [], "additional_components": [ "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715" ] }, "reaction_10491720": { "compartment": "compartment_7660", "id": "reaction_10491720", "reactome": "R-DME-8878050", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491687" ], "products": [ "species_113582", "species_10491717" ], "modifiers": [ [ "species_10469635", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617", "FBgn0035142" ] }, "reaction_10491722": { "compartment": "compartment_7660", "id": "reaction_10491722", "reactome": "R-DME-8878054", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10489794" ], "products": [ "species_113582", "species_10491715" ], "modifiers": [ [ "species_10469635", "catalyst" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0035142" ] }, "reaction_10492299": { "compartment": "compartment_7660", "id": "reaction_10492299", "reactome": "R-DME-8937989", "name": "RUNX1 binds PRC1 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492295", "species_10489794" ], "products": [ "species_10492297" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10491724": { "compartment": "compartment_7660", "id": "reaction_10491724", "reactome": "R-DME-8878056", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489794", "species_10458126" ], "products": [ "species_10491687" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0261617", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10492446": { "compartment": "compartment_7660", "id": "reaction_10492446", "reactome": "R-DME-8938913", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492442", "species_10489794" ], "products": [ "species_10492444" ], "modifiers": [], "additional_components": [ "FBgn0000567", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "P11536", "FBgn0000567" ] }, "reaction_10492480": { "compartment": "compartment_7660", "id": "reaction_10492480", "reactome": "R-DME-8938951", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492476", "species_10489794" ], "products": [ "species_10492478" ], "modifiers": [], "additional_components": [ "O16117", "FBgn0005561", "O18381", "FBgn0005558", "P23758", "FBgn0003130", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "O16117", "FBgn0005561", "O18381", "FBgn0005558", "P23758", "FBgn0003130" ] }, "reaction_10492459": { "compartment": "compartment_7660", "id": "reaction_10492459", "reactome": "R-DME-8938930", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492455", "species_10489794" ], "products": [ "species_10492457" ], "modifiers": [], "additional_components": [ "P11536", "FBgn0000567", "Q01842", "FBgn0000097", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "P11536", "FBgn0000567", "Q01842", "FBgn0000097" ] }, "reaction_10494980": { "compartment": "compartment_7660", "id": "reaction_10494980", "reactome": "R-DME-8953115", "name": "E2F6:TFDP1 binds to MGA:MAX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494970", "species_10494976" ], "products": [ "species_10494978" ], "modifiers": [], "additional_components": [ "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763" ] }, "reaction_10495062": { "compartment": "compartment_7660", "id": "reaction_10495062", "reactome": "R-DME-8954082", "name": "E2F6 binds the PRC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495049", "species_10495058" ], "products": [ "species_10495060" ], "modifiers": [], "additional_components": [ "Q9W215", "FBgn0034763", "Q9VB08", "FBgn0003330", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "Q9VKL0", "FBgn0032330", "P39769", "FBgn0004861", "Q9W523", "FBgn0004860", "Q9W215", "FBgn0034763", "Q9VB08", "FBgn0003330", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "Q9VKL0", "FBgn0032330", "P39769", "FBgn0004861", "Q9W523", "FBgn0004860" ] }, "reaction_10495047": { "compartment": "compartment_7660", "id": "reaction_10495047", "reactome": "R-DME-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494968", "species_10457961" ], "products": [ "species_10495045" ], "modifiers": [], "additional_components": [ "FBgn0011763", "Q24318", "FBgn0011763", "Q27368", "phospho-E2f1" ] }, "reaction_10494984": { "compartment": "compartment_7660", "id": "reaction_10494984", "reactome": "R-DME-8953418", "name": "EHMT1:EHMT2 complex binds E2F6.com-1 core", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468978", "species_10494978" ], "products": [ "species_10494982" ], "modifiers": [], "additional_components": [ "M9PGH7", "FBgn0040372", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "M9PGH7", "FBgn0040372" ] }, "reaction_10495850": { "compartment": "compartment_7660", "id": "reaction_10495850", "reactome": "R-DME-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10494968" ], "products": [ "species_113582", "species_10495848" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "FBgn0261278" ] }, "reaction_10494972": { "compartment": "compartment_7660", "id": "reaction_10494972", "reactome": "R-DME-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457959", "species_10494968" ], "products": [ "species_10494970" ], "modifiers": [], "additional_components": [ "FBgn0011763", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763" ] }, "reaction_10495839": { "compartment": "compartment_7660", "id": "reaction_10495839", "reactome": "R-DME-9007283", "name": "CBX3 and PRC1.6 associate with E2F6.com-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495835", "species_10494982", "species_10495829" ], "products": [ "species_10495837" ], "modifiers": [], "additional_components": [ "Q9VK33", "FBgn0032475", "Q9VB08", "FBgn0003330", "Q9W215", "FBgn0034763", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "M9PGH7", "FBgn0040372", "FBgn0039019", "Q9VCU6", "FBgn0039019", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "M9PGH7", "FBgn0040372", "Q9VK33", "FBgn0032475", "Q9VB08", "FBgn0003330", "Q9W215", "FBgn0034763" ] }, "reaction_10492290": { "compartment": "compartment_70101", "id": "reaction_10492290", "reactome": "R-DME-8937807", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492282", "species_113592" ], "products": [ "species_10492287", "species_29370", "species_10444503" ], "modifiers": [ [ "species_10492282", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "M9PI08", "FBgn0083981", "FBgn0083981", "FBgn0262733", "P00528", "FBgn0262733", "M9PI08", "FBgn0083981" ] }, "reaction_10492292": { "compartment": "compartment_70101", "id": "reaction_10492292", "reactome": "R-DME-8937814", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492280" ], "products": [ "species_10489801" ], "modifiers": [ [ "species_10437860", "catalyst" ], [ "species_10444503", "inhibitor" ] ], "additional_components": [ "FBgn0083981", "FBgn0083981", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "FBgn0262733" ] }, "reaction_10494821": { "compartment": "compartment_7660", "id": "reaction_10494821", "reactome": "R-DME-8952419", "name": "SMURFs ubiquitinate RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10489801" ], "products": [ "species_10494816" ], "modifiers": [ [ "species_10494818", "catalyst" ], [ "species_10458126", "inhibitor" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0083981", "FBgn0083981", "FBgn0029006", "FBgn0261617" ] }, "reaction_10492284": { "compartment": "compartment_70101", "id": "reaction_10492284", "reactome": "R-DME-8937792", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492280", "species_10444503" ], "products": [ "species_10492282" ], "modifiers": [], "additional_components": [ "FBgn0083981", "FBgn0262733", "P00528", "FBgn0262733", "M9PI08", "FBgn0083981" ] }, "reaction_10494812": { "compartment": "compartment_7660", "id": "reaction_10494812", "reactome": "R-DME-8952399", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494808" ], "products": [ "species_10494810" ], "modifiers": [], "additional_components": [ "FBgn0083981", "FBgn0083981" ] }, "reaction_10489805": { "compartment": "compartment_7660", "id": "reaction_10489805", "reactome": "R-DME-8865454", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10489782" ], "products": [ "species_10489803" ], "modifiers": [], "additional_components": [ "FBgn0083981", "FBgn0013753", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981" ] }, "reaction_10494814": { "compartment": "compartment_70101", "id": "reaction_10494814", "reactome": "R-DME-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494810" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "FBgn0083981", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10493669": { "compartment": "compartment_7660", "id": "reaction_10493669", "reactome": "R-DME-8951428", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468258", "species_10489801" ], "products": [ "species_10493667" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0083981", "M9PI08", "FBgn0083981", "P18824", "arm", "Q8IMA8", "FBgn0085432" ] }, "reaction_10445384": { "compartment": "compartment_7660", "id": "reaction_10445384", "reactome": "R-DME-376419", "name": "Formation of NR-MED1 Coactivator Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445380", "species_10445375" ], "products": [ "species_10445382" ], "modifiers": [], "additional_components": [ "FBgn0037109", "P13054", "FBgn0001323", "P16376", "FBgn0003651", "Q05192", "FBgn0261239", "P33244", "FBgn0001078", "Q24142", "FBgn0015239", "P49866", "FBgn0004914", "P49869", "FBgn0014859", "Q24143", "FBgn0015240", "P34021", "FBgn0000546", "A1ZA01", "FBgn0034012", "P18102", "FBgn0003720", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P31396", "FBgn0000448", "Q9Y0Y6", "FBgn0027497", "P45447", "FBgn0004865", "E1JHX0", "FBgn0260756", "Q8WS79", "FBgn0035849", "P13054", "FBgn0001323", "P16376", "FBgn0003651", "Q05192", "FBgn0261239", "P33244", "FBgn0001078", "Q24142", "FBgn0015239", "P49866", "FBgn0004914", "P49869", "FBgn0014859", "Q24143", "FBgn0015240", "P34021", "FBgn0000546", "A1ZA01", "FBgn0034012", "P18102", "FBgn0003720", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P31396", "FBgn0000448", "Q9Y0Y6", "FBgn0027497", "P45447", "FBgn0004865", "E1JHX0", "FBgn0260756", "Q8WS79", "FBgn0035849", "Q9VP05", "FBgn0037109" ] }, "reaction_10488872": { "compartment": "compartment_7660", "id": "reaction_10488872", "reactome": "R-DME-8853965", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488868", "species_10488864" ], "products": [ "species_10441673", "species_10488870" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0000529", "Q04787", "FBgn0000529", "Q8IMA8", "FBgn0085432" ] }, "reaction_10490422": { "compartment": "compartment_7660", "id": "reaction_10490422", "reactome": "R-DME-8869580", "name": "DEK binds TFAP2A homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489710", "species_10490418" ], "products": [ "species_10490420" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0026533", "Q8T0D3", "FBgn0026533", "M9PIH9", "FBgn0261953" ] }, "reaction_10489712": { "compartment": "compartment_7660", "id": "reaction_10489712", "reactome": "R-DME-8864278", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489702" ], "products": [ "species_10489710" ], "modifiers": [], "additional_components": [ "FBgn0261953", "M9PIH9", "FBgn0261953" ] }, "reaction_10489731": { "compartment": "compartment_70101", "id": "reaction_10489731", "reactome": "R-DME-8864577", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489725" ], "products": [ "species_10467863" ], "modifiers": [ [ "species_10489727", "inhibitor" ] ], "additional_components": [ "FBgn0261953", "FBgn0261953", "Q9VLU5", "FBgn0031972", "M9PIH9", "FBgn0261953" ] }, "reaction_10489743": { "compartment": "compartment_7660", "id": "reaction_10489743", "reactome": "R-DME-8864595", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489739", "species_10489737" ], "products": [ "species_10489741" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0031873", "Q9VM63", "FBgn0031873", "M9PIH9", "FBgn0261953" ] }, "reaction_10489729": { "compartment": "compartment_70101", "id": "reaction_10489729", "reactome": "R-DME-8864569", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489725", "species_10458536" ], "products": [ "species_10489727" ], "modifiers": [], "additional_components": [ "FBgn0261953", "FBgn0031972", "Q9VLU5", "FBgn0031972", "M9PIH9", "FBgn0261953" ] }, "reaction_10489721": { "compartment": "compartment_7660", "id": "reaction_10489721", "reactome": "R-DME-8864343", "name": "KCTD1 binds TFAP2 homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489710", "species_10489717" ], "products": [ "species_10489719" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0034636", "D5SHR0", "FBgn0034636", "M9PIH9", "FBgn0261953" ] }, "reaction_10489769": { "compartment": "compartment_7660", "id": "reaction_10489769", "reactome": "R-DME-8865265", "name": "TFAP2C homodimer binds MYC and KDM5B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467865", "species_10489765", "species_10489760" ], "products": [ "species_10489767" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0031759", "FBgn0262656", "Q9W4S7", "FBgn0262656", "Q9VMJ7", "FBgn0031759", "M9PIH9", "FBgn0261953" ] }, "reaction_10497665": { "compartment": "compartment_7660", "id": "reaction_10497665", "reactome": "R-DME-9620515", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10441099" ], "products": [ "species_2485002", "species_10497660" ], "modifiers": [ [ "species_10497662", "catalyst" ], [ "species_3785707", "catalyst" ] ], "additional_components": [ "Q9VTZ1", "FBgn0020388" ] }, "reaction_10497764": { "compartment": "compartment_7660", "id": "reaction_10497764", "reactome": "R-DME-9626928", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441097", "species_10447242" ], "products": [ "species_10497762" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9MS40", "FBgn0261617", "Q95V55", "foxo" ] }, "reaction_10497672": { "compartment": "compartment_7660", "id": "reaction_10497672", "reactome": "R-DME-9620532", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497660", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10441099" ], "modifiers": [ [ "species_10497669", "catalyst" ] ], "additional_components": [ "Q9I7I7", "FBgn0038788", "Q9VK34", "FBgn0024291" ] }, "reaction_10497573": { "compartment": "compartment_70101", "id": "reaction_10497573", "reactome": "R-DME-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497569", "species_10443103" ], "products": [ "species_10497571" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "Q95V55", "foxo", "P29310", "14-3-3zeta" ] }, "reaction_10497579": { "compartment": "compartment_70101", "id": "reaction_10497579", "reactome": "R-DME-9614562", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497563", "species_10497575" ], "products": [ "species_10497577" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "Q95V55", "foxo" ] }, "reaction_10497567": { "compartment": "compartment_7660", "id": "reaction_10497567", "reactome": "R-DME-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441108" ], "products": [ "species_10443103" ], "modifiers": [], "additional_components": [] }, "reaction_10497583": { "compartment": "compartment_70101", "id": "reaction_10497583", "reactome": "R-DME-9614564", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497565", "species_10432006" ], "products": [ "species_10497581" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "Q95V55", "foxo" ] }, "reaction_10497637": { "compartment": "compartment_7660", "id": "reaction_10497637", "reactome": "R-DME-9618021", "name": "FOXG1 binds FOXO:SMAD complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497628", "species_10497633" ], "products": [ "species_10497635" ], "modifiers": [], "additional_components": [ "Q95V55", "foxo", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0004567", "P32031", "FBgn0004567", "Q95V55", "foxo", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10497626": { "compartment": "compartment_7660", "id": "reaction_10497626", "reactome": "R-DME-9617996", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441097", "species_10437946" ], "products": [ "species_10497624" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q95V55", "foxo" ] }, "reaction_10434814": { "compartment": "compartment_7660", "id": "reaction_10434814", "reactome": "R-DME-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434775" ], "products": [ "species_10434775" ], "modifiers": [], "additional_components": [ "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10434808": { "compartment": "compartment_7660", "id": "reaction_10434808", "reactome": "R-DME-112437", "name": "Formation of NELF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434644", "species_10434629", "species_10434634", "species_10434639" ], "products": [ "species_10434646" ], "modifiers": [], "additional_components": [ "FBgn0017430", "FBgn0038872", "FBgn0027553", "FBgn0010416", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430" ] }, "reaction_10434806": { "compartment": "compartment_7660", "id": "reaction_10434806", "reactome": "R-DME-112436", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434710", "species_10434715" ], "products": [ "species_10434721" ], "modifiers": [], "additional_components": [ "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "FBgn0039066", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212" ] }, "reaction_10432469": { "compartment": "compartment_7660", "id": "reaction_10432469", "reactome": "R-DME-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432459" ], "products": [ "species_10432467" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10434804": { "compartment": "compartment_7660", "id": "reaction_10434804", "reactome": "R-DME-112435", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434708", "species_10434703" ], "products": [ "species_10434710" ], "modifiers": [], "additional_components": [ "FBgn0023212", "FBgn0266711", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212" ] }, "reaction_10434802": { "compartment": "compartment_7660", "id": "reaction_10434802", "reactome": "R-DME-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433111", "species_10434651" ], "products": [ "species_10434653" ], "modifiers": [], "additional_components": [ "FBgn0040273", "FBgn0028683", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273" ] }, "reaction_10434800": { "compartment": "compartment_7660", "id": "reaction_10434800", "reactome": "R-DME-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434608", "species_10434622" ], "products": [ "species_10434624" ], "modifiers": [], "additional_components": [ "FBgn0019949", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434798": { "compartment": "compartment_7660", "id": "reaction_10434798", "reactome": "R-DME-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434691", "species_10434696" ], "products": [ "species_10434698" ], "modifiers": [], "additional_components": [ "FBgn0010278", "FBgn0002183", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278" ] }, "reaction_10431436": { "compartment": "compartment_7660", "id": "reaction_10431436", "reactome": "R-DME-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431434" ], "products": [ "species_10431317", "species_10431174", "species_10431432", "species_10429256", "species_10431322", "species_109877", "species_10431420" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10432457": { "compartment": "compartment_7660", "id": "reaction_10432457", "reactome": "R-DME-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432455" ], "products": [ "species_10431317", "species_10431174", "species_10431432", "species_10429256", "species_10431322", "species_110068", "species_10431420" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10434822": { "compartment": "compartment_7660", "id": "reaction_10434822", "reactome": "R-DME-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434780" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434790": { "compartment": "compartment_7660", "id": "reaction_10434790", "reactome": "R-DME-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434788" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10432613": { "compartment": "compartment_7660", "id": "reaction_10432613", "reactome": "R-DME-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432611" ], "products": [ "species_10431174", "species_75897", "species_10431432", "species_10429256" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10434820": { "compartment": "compartment_7660", "id": "reaction_10434820", "reactome": "R-DME-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434780" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434786": { "compartment": "compartment_7660", "id": "reaction_10434786", "reactome": "R-DME-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434784" ], "products": [ "species_10434780" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434816": { "compartment": "compartment_7660", "id": "reaction_10434816", "reactome": "R-DME-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434784" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10433419": { "compartment": "compartment_7660", "id": "reaction_10433419", "reactome": "R-DME-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432082", "species_10431174" ], "products": [ "species_10432467" ], "modifiers": [], "additional_components": [ "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10433417": { "compartment": "compartment_7660", "id": "reaction_10433417", "reactome": "R-DME-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429256", "species_10432078" ], "products": [ "species_10432080" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10433415": { "compartment": "compartment_7660", "id": "reaction_10433415", "reactome": "R-DME-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431317", "species_10431322", "species_10432076" ], "products": [ "species_10432078" ], "modifiers": [], "additional_components": [ "P52654", "FBgn0011289", "P52656", "FBgn0013347", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10433413": { "compartment": "compartment_7660", "id": "reaction_10433413", "reactome": "R-DME-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10431420" ], "products": [ "species_10432076" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10432084": { "compartment": "compartment_7660", "id": "reaction_10432084", "reactome": "R-DME-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432080", "species_10431432" ], "products": [ "species_10432082" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10486881": { "compartment": "compartment_7660", "id": "reaction_10486881", "reactome": "R-DME-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10486869" ], "products": [ "species_113582", "species_10486878" ], "modifiers": [ [ "species_10486869", "catalyst" ] ], "additional_components": [ "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24216", "FBgn0263237", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24216", "FBgn0263237", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10486883": { "compartment": "compartment_7660", "id": "reaction_10486883", "reactome": "R-DME-6810238", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487478" ], "products": [ "species_10487486", "species_10487480" ], "modifiers": [ [ "species_10487478", "catalyst" ], [ "species_10430034", "catalyst" ], [ "species_10487492", "catalyst" ] ], "additional_components": [ "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "X2JAA3", "FBgn0032688", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", 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"FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", 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"FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "FBgn0264962", "FBgn0031054" ] }, "reaction_10487465": { "compartment": "compartment_7660", "id": "reaction_10487465", "reactome": "R-DME-6814549", "name": "Pre-snRNA transcript initiation, Integrator binding, LEC binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29470", "species_29358", "species_113562", "species_113571", "species_10487441", "species_10487456", "species_10487360" ], "products": [ "species_10487462" ], "modifiers": [ [ "species_10487360", "catalyst" ], [ "species_10434653", "catalyst" ] ], "additional_components": [ "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", 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demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "X2JAA3", "FBgn0032688", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10487630": { "compartment": "compartment_7660", "id": "reaction_10487630", "reactome": "R-DME-6814885", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429169", "species_10487498", "species_10440022", "species_10429515" ], "products": [ "species_10487478" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "X2JAA3", "FBgn0032688", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P04052", "FBgn0003277", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "species_430042", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "FBgn0033380", "FBgn0033062", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "X2JAA3", "FBgn0032688", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P04052", "FBgn0003277", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "species_430042", "Q9V9K7", "FBgn0033062", "A1Z7P3", "FBgn0033380", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10471026": { "compartment": "compartment_7660", "id": "reaction_10471026", "reactome": "R-DME-5221061", "name": "TDG excises 5-carboxylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5220996", "species_10433855" ], "products": [ "species_10433873", "species_5221064" ], "modifiers": [ [ "species_10433855", "catalyst" ] ], "additional_components": [ "FBgn0026869", "Q9V4D8", "FBgn0026869", "FBgn0026869" ] }, "reaction_10471024": { "compartment": "compartment_7660", "id": "reaction_10471024", "reactome": "R-DME-5220959", "name": "TDG excises 5-formylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5221062", "species_10433855" ], "products": [ "species_10433873", "species_5221065" ], "modifiers": [ [ "species_10433855", "catalyst" ] ], "additional_components": [ "FBgn0026869", "Q9V4D8", "FBgn0026869", "FBgn0026869" ] }, "reaction_209227": { "compartment": "compartment_70101", "id": "reaction_209227", "reactome": "R-DME-209227", "name": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The Drosophila orthologue of IKKB (IRD5) phosphorylates Relish (REL).", "reactants": [ "species_113592", "species_354323" ], "products": [ "species_29370", "species_354322" ], "modifiers": [ [ "species_206633", "catalyst" ] ], "additional_components": [ "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta" ] }, "reaction_214398": { "compartment": "compartment_70101", "id": "reaction_214398", "reactome": "R-DME-214398", "name": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The Drosophila orthologue of IKKB (IRD5) phosphorylates Relish (REL).", "reactants": [ "species_113592", "species_214406" ], "products": [ "species_29370", "species_214409" ], "modifiers": [ [ "species_206633", "catalyst" ] ], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta" ] }, "reaction_209200": { "compartment": "compartment_70101", "id": "reaction_209200", "reactome": "R-DME-209200", "name": "HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex", "reversible": "false", "notes": "MAP kinase kinase orthologue, the dual specificity kinase Hemipterous (HEP), is phosphorylated and activated in its activation loop at residues Ser348 and Thr352 by the MAP kinase kinase kinase orthologue, phosphorylated TAK1.", "reactants": [ "species_113592", "species_206293" ], "products": [ "species_29370", "species_205776" ], "modifiers": [ [ "species_206922", "catalyst" ] ], "additional_components": [ "P35128", "ben", "Q24307", "Diap2", "Q9V3Q6", "TAK1", "Q4TZQ4", "TAB2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209188": { "compartment": "compartment_70101", "id": "reaction_209188", "reactome": "R-DME-209188", "name": "TAK1-binding protein TAB2 binds to TAK1 kinase", "reversible": "false", "notes": "Areas in the C-terminal part of TAB2 (not the Zinc-finger domain) bind to TAK1 Ser/Thr kinase.", "reactants": [ "species_205754", "species_206059" ], "products": [ "species_206731" ], "modifiers": [], "additional_components": [ "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1" ] }, "reaction_209179": { "compartment": "compartment_70101", "id": "reaction_209179", "reactome": "R-DME-209179", "name": "IAP2:BEN:UEV1A E3 ligase complex auto-ubiquitinates", "reversible": "false", "notes": "The Apoptosis 2 Inhibitor (IAP2):Bendless (BEN):UEV1A E3 ubiquitin ligase complex autoubiquitinates, forming Lys63-linked ubiquitin chains.", "reactants": [ "species_206204", "species_207030" ], "products": [ "species_206608" ], "modifiers": [ [ "species_205735", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q9VRL1", "Uev1A", "P35128", "ben", "Q24307", "Diap2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209289": { "compartment": "compartment_70101", "id": "reaction_209289", "reactome": "R-DME-209289", "name": "TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase", "reversible": "false", "notes": "TAB2 in complex with TAK1 kinase binds to the ubiquitin chains emanating from the Apoptosis 2 Inhibitor (IAP2):Bendless (BEN):UEV1A E3 ligase complex. The formation of an E3 ligase:TAB2:TAK1 complex may cause conformational changes to the catalytic domain of TAK1 thus inducing its kinase activity.", "reactants": [ "species_206731", "species_206608" ], "products": [ "species_206764" ], "modifiers": [], "additional_components": [ "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "P35128", "ben", "Q24307", "Diap2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209320": { "compartment": "compartment_70101", "id": "reaction_209320", "reactome": "R-DME-209320", "name": "Activated TAK1 kinase is autophosphorylated", "reversible": "false", "notes": "TAK1 kinase is phosphorylated at Thr171 by another activated TAK1 kinase in an intermolecular autophosphorylation.", "reactants": [ "species_206764", "species_113592" ], "products": [ "species_29370", "species_206922" ], "modifiers": [ [ "species_206764", "catalyst" ] ], "additional_components": [ "P35128", "ben", "Q24307", "Diap2", "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q9V3Q6", "TAK1", "Q4TZQ4", "TAB2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209240": { "compartment": "compartment_70101", "id": "reaction_209240", "reactome": "R-DME-209240", "name": "Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5", "reversible": "false", "notes": "IRD5 is phosphorylated and activated by phosphorylated TAK1 kinase at residues Thr217 and Ser221 in the activation loop.", "reactants": [ "species_113592", "species_206628" ], "products": [ "species_29370", "species_206633" ], "modifiers": [ [ "species_206922", "catalyst" ] ], "additional_components": [ "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta", "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta", "P35128", "ben", "Q24307", "Diap2", "Q9V3Q6", "TAK1", "Q4TZQ4", "TAB2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_354273": { "compartment": "compartment_7660", "id": "reaction_354273", "reactome": "R-DME-354273", "name": "AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene", "reversible": "false", "notes": "When the JNK pathway is activated, the AP-1 transcription factor, a complex Jun-related antigen (JRA) and Kayak (KAY), forms a complex with the HMG protein, dorsal switch protein (DSP1) and STAT92E transcription factor (involved in the JAK/STAT pathway). This 'repressosome complex' and phosphorylated Relish (REL-68) are mutually exclusive in binding to this gene and so phosphorylated REL-68 is displaced from its target gene.", "reactants": [ "species_354268", "species_354285", "species_206244", "species_206724" ], "products": [ "species_354283", "species_354287", "species_354279" ], "modifiers": [], "additional_components": [ "O76216", "PCAF", "Q94527", "Rel", "P21525", "phospho-kay", "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q24151", "Stat92E", "Q24537", "Dsp1", "P18289", "phospho-Jra" ] }, "reaction_354289": { "compartment": "compartment_7660", "id": "reaction_354289", "reactome": "R-DME-354289", "name": "AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene", "reversible": "false", "notes": "The 'repressosome complex' recruits the histone deacetylase RPD3 aka HDAC1 to the Relish target gene resulting in repression of its transcription. This is an example of the JNK pathway downregulating the Imd pathway.", "reactants": [ "species_354283", "species_354293" ], "products": [ "species_354291" ], "modifiers": [], "additional_components": [ "P21525", "phospho-kay", "Q24151", "Stat92E", "Q24537", "Dsp1", "P18289", "phospho-Jra", "Q94517", "HDAC1", "P21525", "phospho-kay", "Q24151", "Stat92E", "Q24537", "Dsp1", "P18289", "phospho-Jra" ] }, "reaction_209257": { "compartment": "compartment_7660", "id": "reaction_209257", "reactome": "R-DME-209257", "name": "Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription", "reversible": "false", "notes": "In the nucleus, phosphorylated Relish (REL-68) forms a complex with the histone acetyltransferase, PCAF, at its target gene and transcription is activated.", "reactants": [ "species_354287", "species_354279" ], "products": [ "species_354285" ], "modifiers": [], "additional_components": [ "O76216", "PCAF", "Q94527", "Rel" ] }, "reaction_209309": { "compartment": "compartment_13231", "id": "reaction_209309", "reactome": "R-DME-209309", "name": "Phosphorylated REL-68 transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated N-terminal cleaved domain of Relish (REL-68) translocates from the cytosol to the nucleus. The corresponding phosphorylated C-terminal cleaved domain (REL-49) remains in the cytoplasm.", "reactants": [ "species_354270" ], "products": [ "species_354287" ], "modifiers": [], "additional_components": [] }, "reaction_10472558": { "compartment": "compartment_70101", "id": "reaction_10472558", "reactome": "R-DME-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10472555", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_1562550", "Q9I7K3", "FBgn0037818" ] }, "reaction_10472539": { "compartment": "compartment_876", "id": "reaction_10472539", "reactome": "R-DME-5433067", "name": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490235" ], "products": [ "species_266029", "species_5490250" ], "modifiers": [ [ "species_10443761", "catalyst" ] ], "additional_components": [ "CHEBI:78579", "CHEBI:78584", "CHEBI:78578", "CHEBI:78583", "Q9VBG1", "FBgn0039420", "X2JCU8", "FBgn0266100", "Q9VPG0", "FBgn0036986", "Q9VJ94", "FBgn0261804", "species_1562550" ] }, "reaction_10472537": { "compartment": "compartment_70101", "id": "reaction_10472537", "reactome": "R-DME-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10438532", "catalyst" ] ], "additional_components": [ "CHEBI:30725", "CHEBI:78586", "CHEBI:78581", "CHEBI:78587", "Q8SY19", "FBgn0025814" ] }, "reaction_10472548": { "compartment": "compartment_984", "id": "reaction_10472548", "reactome": "R-DME-5433072", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490253", "species_109276" ], "products": [ "species_210382", "species_5490235" ], "modifiers": [ [ "species_10472545", "catalyst" ] ], "additional_components": [ "CHEBI:78581", "CHEBI:78587", "CHEBI:78579", "CHEBI:78584", "Q7KUX2", "FBgn0030796", "M9NFP5", "FBgn0025837", "Q9VYR2", "FBgn0030361", "Q9VWT3", "FBgn0030932" ] }, "reaction_10486816": { "compartment": "compartment_17951", "id": "reaction_10486816", "reactome": "R-DME-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10486813", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VM80", "FBgn0031860" ] }, "reaction_10446586": { "compartment": "compartment_17951", "id": "reaction_10446586", "reactome": "R-DME-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_389678" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10446580", "catalyst" ] ], "additional_components": [ "species_76629", "A1Z8D3", "FBgn0061356" ] }, "reaction_10481081": { "compartment": "compartment_5460", "id": "reaction_10481081", "reactome": "R-DME-6793590", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478187", "species_10481070" ], "products": [ "species_10481073", "species_10436440" ], "modifiers": [ [ "species_10481078", "catalyst" ] ], "additional_components": [ "FBgn0027945", "CHEBI:25650", "Q94519", "FBgn0011361", "FBgn0027945", "FBgn0011361", "FBgn0037251" ] }, "reaction_10481048": { "compartment": "compartment_5460", "id": "reaction_10481048", "reactome": "R-DME-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481032", "species_10478185" ], "products": [ "species_10481040", "species_10478187" ], "modifiers": [ [ "species_10481045", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "species_8878387", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "species_113596", "Q9VVL7", "FBgn0036762", "Q9VM14", "FBgn0283658", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "Q9VA02", "FBgn0039827", "Q9VXY3", "FBgn0030612", "Q7PLE6", "FBgn0039993", "Q9VHB8", "FBgn0037709", "FBgn0027945", "Q9VA02", "FBgn0039827", "Q7PLE6", "FBgn0039993", "Q9VHB8", "FBgn0037709", "species_8878387", "Q9VXY3", "FBgn0030612", "species_113596", "Q9VVL7", "FBgn0036762", "Q9VM14", "FBgn0283658", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "FBgn0027945", "FBgn0265178" ] }, "reaction_10479511": { "compartment": "compartment_5460", "id": "reaction_10479511", "reactome": "R-DME-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784236", "species_113587" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10428224", "catalyst" ] ], "additional_components": [ "Q8IPY3", "FBgn0001125" ] }, "reaction_10446583": { "compartment": "compartment_17951", "id": "reaction_10446583", "reactome": "R-DME-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389822" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10446580", "catalyst" ] ], "additional_components": [ "species_76629", "A1Z8D3", "FBgn0061356" ] }, "reaction_10454421": { "compartment": "compartment_5460", "id": "reaction_10454421", "reactome": "R-DME-904864", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_904849", "species_379697" ], "products": [ "species_159549", "species_113557" ], "modifiers": [ [ "species_10454418", "catalyst" ] ], "additional_components": [ "A8E6R2", "FBgn0037186" ] }, "reaction_10479508": { "compartment": "compartment_5460", "id": "reaction_10479508", "reactome": "R-DME-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10479505", "catalyst" ] ], "additional_components": [ "Q04499", "FBgn0003423", "species_113596" ] }, "reaction_10446546": { "compartment": "compartment_17951", "id": "reaction_10446546", "reactome": "R-DME-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_193446" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10446543", "catalyst" ] ], "additional_components": [ "Q9VM80", "FBgn0031860", "Q7JZB1", "FBgn0033543", "species_113596" ] }, "reaction_10446507": { "compartment": "compartment_17951", "id": "reaction_10446507", "reactome": "R-DME-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_389664" ], "products": [ "species_389680", "species_193446" ], "modifiers": [ [ "species_10446504", "catalyst" ] ], "additional_components": [ "Q9W3Z3", "FBgn0014031" ] }, "reaction_10446571": { "compartment": "compartment_17951", "id": "reaction_10446571", "reactome": "R-DME-389826", "name": "glyoxylate + NADPH + H+ => glycolate + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_389678", "species_113602" ], "products": [ "species_389822", "species_389556" ], "modifiers": [ [ "species_10446568", "catalyst" ] ], "additional_components": [ "Q8INU6", "FBgn0051674", "Q8I725", "FBgn0037370", "Q9VII9", "FBgn0051673", "Q8SZU0", "FBgn0032889" ] }, "reaction_10481350": { "compartment": "compartment_70101", "id": "reaction_10481350", "reactome": "R-DME-6798317", "name": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_29424" ], "products": [ "species_5359017", "species_71285" ], "modifiers": [ [ "species_10481347", "catalyst" ] ], "additional_components": [ "Q9VG42", "FBgn0038074" ] }, "reaction_10478200": { "compartment": "compartment_5460", "id": "reaction_10478200", "reactome": "R-DME-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10478185" ], "products": [ "species_10478189", "species_29376" ], "modifiers": [ [ "species_10478197", "catalyst" ] ], "additional_components": [ "FBgn0027945", "Q9U616", "FBgn0027945", "CHEBI:14949", "Q9VH09", "FBgn0037801" ] }, "reaction_10478215": { "compartment": "compartment_5460", "id": "reaction_10478215", "reactome": "R-DME-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_10478202" ], "products": [ "species_113529", "species_10478185", "species_29362" ], "modifiers": [ [ "species_10478212", "catalyst" ] ], "additional_components": [ "Q9U616", "FBgn0027945", "CHEBI:50746", "FBgn0027945", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10478210": { "compartment": "compartment_5460", "id": "reaction_10478210", "reactome": "R-DME-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_10478189" ], "products": [ "species_5693978", "species_5693984", "species_10478202" ], "modifiers": [ [ "species_10478207", "catalyst" ] ], "additional_components": [ "Q9U616", "FBgn0027945", "CHEBI:14949", "Q9U616", "FBgn0027945", "CHEBI:50746", "FBgn0032287" ] }, "reaction_10481091": { "compartment": "compartment_5460", "id": "reaction_10481091", "reactome": "R-DME-6793591", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481073", "species_6793610", "species_2162265" ], "products": [ "species_379705", "species_6793613", "species_10478185" ], "modifiers": [ [ "species_10481088", "catalyst" ] ], "additional_components": [ "FBgn0027945", "FBgn0027945", "Q7JQW6", "FBgn0029158", "CHEBI:49883" ] }, "reaction_10428303": { "compartment": "compartment_5460", "id": "reaction_10428303", "reactome": "R-DME-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_379717" ], "products": [ "species_113529", "species_113590", "species_164934" ], "modifiers": [ [ "species_10428300", "catalyst" ] ], "additional_components": [ "FBgn0003423" ] }, "reaction_10495134": { "compartment": "compartment_5460", "id": "reaction_10495134", "reactome": "R-DME-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10479501", "catalyst" ] ], "additional_components": [ "FBgn0003423" ] }, "reaction_10444090": { "compartment": "compartment_70101", "id": "reaction_10444090", "reactome": "R-DME-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10444087", "catalyst" ] ], "additional_components": [ "FBgn0019932" ] }, "reaction_10444074": { "compartment": "compartment_70101", "id": "reaction_10444074", "reactome": "R-DME-351210", "name": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_204635" ], "products": [ "species_353560", "species_353106" ], "modifiers": [ [ "species_10444071", "catalyst" ] ], "additional_components": [ "FBgn0036272" ] }, "reaction_10444024": { "compartment": "compartment_70101", "id": "reaction_10444024", "reactome": "R-DME-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444018", "species_10444005" ], "products": [ "species_10444022" ], "modifiers": [], "additional_components": [ "P40807", "FBgn0013307", "P40808", "FBgn0013308", "P54361", "FBgn0014184", "P40808", "FBgn0013308", "P40807", "FBgn0013307", "P40808", "FBgn0013308", "P40807", "FBgn0013307", "P54361", "FBgn0014184" ] }, "reaction_10444007": { "compartment": "compartment_70101", "id": "reaction_10444007", "reactome": "R-DME-350567", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428317", "species_10443999" ], "products": [ "species_10444005" ], "modifiers": [], "additional_components": [ "P40808", "FBgn0013308", "P40807", "FBgn0013307", "FBgn0014184", "P54361", "FBgn0014184", "P40808", "FBgn0013308", "P40807", "FBgn0013307" ] }, "reaction_10444258": { "compartment": "compartment_70101", "id": "reaction_10444258", "reactome": "R-DME-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444005" ], "products": [ "species_10443999" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P54361", "FBgn0014184", "P40808", "FBgn0013308", "P40807", "FBgn0013307", "FBgn0014184", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10444012": { "compartment": "compartment_70101", "id": "reaction_10444012", "reactome": "R-DME-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10444009", "catalyst" ] ], "additional_components": [ "FBgn0013307" ] }, "reaction_10444082": { "compartment": "compartment_70101", "id": "reaction_10444082", "reactome": "R-DME-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_204635", "species_353106" ], "modifiers": [ [ "species_10444079", "catalyst" ] ], "additional_components": [ "FBgn0037723" ] }, "reaction_10428320": { "compartment": "compartment_70101", "id": "reaction_10428320", "reactome": "R-DME-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10428317", "catalyst" ] ], "additional_components": [ "P40808", "FBgn0013308", "P40807", "FBgn0013307" ] }, "reaction_10479998": { "compartment": "compartment_5460", "id": "reaction_10479998", "reactome": "R-DME-6788611", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788606", "species_113573" ], "products": [ "species_5696409", "species_113525" ], "modifiers": [ [ "species_10479995", "catalyst" ] ], "additional_components": [ "FBgn0086909" ] }, "reaction_10428637": { "compartment": "compartment_5460", "id": "reaction_10428637", "reactome": "R-DME-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70955" ], "products": [ "species_71045", "species_31649", "species_29376" ], "modifiers": [ [ "species_10428634", "catalyst" ] ], "additional_components": [ "Q9VMC6", "FBgn0031824", "species_113596" ] }, "reaction_10478071": { "compartment": "compartment_17951", "id": "reaction_10478071", "reactome": "R-DME-5693347", "name": "CRYM reduces P2C to PPCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_5693311", "species_113602" ], "products": [ "species_5693325", "species_389556" ], "modifiers": [ [ "species_10478068", "catalyst" ] ], "additional_components": [ "FBgn0030799" ] }, "reaction_10428486": { "compartment": "compartment_5460", "id": "reaction_10428486", "reactome": "R-DME-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113521", "species_30176" ], "products": [ "species_113529", "species_113556", "species_29362", "species_113552" ], "modifiers": [ [ "species_10428480", "catalyst" ] ], "additional_components": [ "Q9VLX0", "FBgn0286198" ] }, "reaction_10428483": { "compartment": "compartment_5460", "id": "reaction_10428483", "reactome": "R-DME-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113529", "species_29444", "species_113600" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10428480", "catalyst" ] ], "additional_components": [ "Q9VLX0", "FBgn0286198" ] }, "reaction_10428627": { "compartment": "compartment_5460", "id": "reaction_10428627", "reactome": "R-DME-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428624", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "species_8878387", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10428496": { "compartment": "compartment_5460", "id": "reaction_10428496", "reactome": "R-DME-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10428493", "catalyst" ] ], "additional_components": [ "Q8SXQ1", "FBgn0036857" ] }, "reaction_10444320": { "compartment": "compartment_5460", "id": "reaction_10444320", "reactome": "R-DME-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113577" ], "products": [ "species_29406", "species_70951" ], "modifiers": [ [ "species_10444317", "catalyst" ] ], "additional_components": [ "FBgn0040383" ] }, "reaction_10481307": { "compartment": "compartment_70101", "id": "reaction_10481307", "reactome": "R-DME-6797956", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618" ], "products": [ "species_6798162" ], "modifiers": [ [ "species_10481304", "catalyst" ] ], "additional_components": [ "FBgn0035523" ] }, "reaction_10481302": { "compartment": "compartment_5460", "id": "reaction_10481302", "reactome": "R-DME-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10428491", "catalyst" ] ], "additional_components": [ "FBgn0036857" ] }, "reaction_10481299": { "compartment": "compartment_5460", "id": "reaction_10481299", "reactome": "R-DME-6797913", "name": "SARDH:FAD oxidatively demethylates SARC to Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6797917", "species_113521" ], "products": [ "species_159549", "species_6797920" ], "modifiers": [ [ "species_10481296", "catalyst" ] ], "additional_components": [ "A1ZAZ2", "FBgn0034276", "species_113596" ] }, "reaction_10460684": { "compartment": "compartment_70101", "id": "reaction_10460684", "reactome": "R-DME-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10460681", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460713": { "compartment": "compartment_70101", "id": "reaction_10460713", "reactome": "R-DME-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_174369" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10460681", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460710": { "compartment": "compartment_70101", "id": "reaction_10460710", "reactome": "R-DME-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111707" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10460681", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10487305": { "compartment": "compartment_70101", "id": "reaction_10487305", "reactome": "R-DME-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_1655445", "species_70106" ], "modifiers": [ [ "species_10487302", "catalyst" ] ], "additional_components": [ "Q9VSD8", "FBgn0035839", "species_111793" ] }, "reaction_10487307": { "compartment": "compartment_70101", "id": "reaction_10487307", "reactome": "R-DME-6814165", "name": "PXLP-K333-GADL1 decarboxylates CSA to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787748" ], "products": [ "species_1655445", "species_113528" ], "modifiers": [ [ "species_10479955", "catalyst" ] ], "additional_components": [ "Q9VPH6", "FBgn0036975", "Q24062", "FBgn0000153" ] }, "reaction_10460723": { "compartment": "compartment_70101", "id": "reaction_10460723", "reactome": "R-DME-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10460720", "catalyst" ] ], "additional_components": [ "A1ZBA8", "FBgn0034364", "species_111793" ] }, "reaction_10460690": { "compartment": "compartment_70101", "id": "reaction_10460690", "reactome": "R-DME-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614582", "species_1614532" ], "modifiers": [ [ "species_10460681", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460671": { "compartment": "compartment_5460", "id": "reaction_10460671", "reactome": "R-DME-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_1614538", "species_113521" ], "products": [ "species_1614617", "species_1614584" ], "modifiers": [ [ "species_10460668", "catalyst" ] ], "additional_components": [ "Q9VWP4", "FBgn0030966", "species_947539" ] }, "reaction_10460708": { "compartment": "compartment_70616", "id": "reaction_10460708", "reactome": "R-DME-1614605", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_10460696", "species_113521" ], "products": [ "species_113529", "species_10460698", "species_1614538" ], "modifiers": [ [ "species_10460705", "catalyst" ] ], "additional_components": [ "FBgn0035515", "FBgn0035515", "Q86PD3", "FBgn0050022", "species_1562550" ] }, "reaction_10438434": { "compartment": "compartment_70101", "id": "reaction_10438434", "reactome": "R-DME-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_71285" ], "products": [ "species_83909", "species_174369" ], "modifiers": [ [ "species_10438431", "catalyst" ] ], "additional_components": [ "species_427523", "Q27580", "FBgn0014455" ] }, "reaction_10495325": { "compartment": "compartment_70101", "id": "reaction_10495325", "reactome": "R-DME-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357660", "species_29356", "species_113592" ], "products": [ "species_29372", "species_70106", "species_8959518", "species_76577" ], "modifiers": [ [ "species_10495322", "catalyst" ] ], "additional_components": [ "FBgn0261270" ] }, "reaction_10428174": { "compartment": "compartment_70101", "id": "reaction_10428174", "reactome": "R-DME-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29468" ], "products": [ "species_29514", "species_29498" ], "modifiers": [ [ "species_10428171", "catalyst" ] ], "additional_components": [ "O76895", "FBgn0023535", "species_266099" ] }, "reaction_10428184": { "compartment": "compartment_70101", "id": "reaction_10428184", "reactome": "R-DME-70573", "name": "argininosuccinate <=> fumarate + arginine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34575" ], "products": [ "species_29468", "species_29586" ], "modifiers": [ [ "species_10428181", "catalyst" ] ], "additional_components": [ "Q9VLG9", "FBgn0032076" ] }, "reaction_10451632": { "compartment": "compartment_5460", "id": "reaction_10451632", "reactome": "R-DME-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374064", "species_113521" ], "products": [ "species_374061", "species_113585" ], "modifiers": [ [ "species_10451629", "catalyst" ] ], "additional_components": [ "O76895", "FBgn0023535", "species_266099" ] }, "reaction_10428272": { "compartment": "compartment_70101", "id": "reaction_10428272", "reactome": "R-DME-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113567", "species_29498" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10428269", "catalyst" ] ], "additional_components": [ "FBgn0030218" ] }, "reaction_10428283": { "compartment": "compartment_5460", "id": "reaction_10428283", "reactome": "R-DME-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10428280", "catalyst" ] ], "additional_components": [ "Q9VW26", "FBgn0022774" ] }, "reaction_10453130": { "compartment": "compartment_5460", "id": "reaction_10453130", "reactome": "R-DME-508040", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113593", "species_113600", "species_113552" ], "products": [ "species_113548", "species_113581", "species_31339", "species_113563" ], "modifiers": [ [ "species_10453127", "catalyst" ] ], "additional_components": [ "Q9VNW6", "FBgn0037146" ] }, "reaction_10479495": { "compartment": "compartment_70101", "id": "reaction_10479495", "reactome": "R-DME-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_35305", "species_29364" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10479492", "catalyst" ] ], "additional_components": [ "Q9VEJ3", "FBgn0038516" ] }, "reaction_10428214": { "compartment": "compartment_5460", "id": "reaction_10428214", "reactome": "R-DME-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10428211", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_29362", "species_427523", "species_29366", "P54385", "FBgn0001098" ] }, "reaction_10428293": { "compartment": "compartment_5460", "id": "reaction_10428293", "reactome": "R-DME-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10428290", "catalyst" ] ], "additional_components": [ "Q9VEJ3", "FBgn0038516" ] }, "reaction_10428229": { "compartment": "compartment_5460", "id": "reaction_10428229", "reactome": "R-DME-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10428211", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_427523", "species_29366", "species_29364", "species_29362", "P54385", "FBgn0001098" ] }, "reaction_10454402": { "compartment": "compartment_70101", "id": "reaction_10454402", "reactome": "R-DME-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29472" ], "products": [ "species_29432", "species_893598" ], "modifiers": [ [ "species_10454393", "catalyst" ] ], "additional_components": [ "Q8SXC2", "FBgn0037955" ] }, "reaction_10479488": { "compartment": "compartment_5460", "id": "reaction_10479488", "reactome": "R-DME-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10479485", "catalyst" ] ], "additional_components": [ "Q9VEJ3", "FBgn0038516" ] }, "reaction_10428750": { "compartment": "compartment_5460", "id": "reaction_10428750", "reactome": "R-DME-71241", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113594", "species_35139" ], "products": [ "species_113546", "species_113536", "species_29376" ], "modifiers": [ [ "species_10428747", "catalyst" ] ], "additional_components": [ "species_351595", "Q9VDM7", "FBgn0038795", "species_111793" ] }, "reaction_10428761": { "compartment": "compartment_70101", "id": "reaction_10428761", "reactome": "R-DME-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_31311", "species_29424" ], "modifiers": [ [ "species_10428758", "catalyst" ] ], "additional_components": [ "Q9W457", "FBgn0029823" ] }, "reaction_10442782": { "compartment": "compartment_984", "id": "reaction_10442782", "reactome": "R-DME-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10478122": { "compartment": "compartment_876", "id": "reaction_10478122", "reactome": "R-DME-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352327" ], "products": [ "species_351628", "species_351629" ], "modifiers": [ [ "species_10478117", "catalyst" ] ], "additional_components": [ "FBgn0283531" ] }, "reaction_10442841": { "compartment": "compartment_984", "id": "reaction_10442841", "reactome": "R-DME-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352030", "species_209818", "species_351629" ], "products": [ "species_109276", "species_352329", "species_351628" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10444056": { "compartment": "compartment_984", "id": "reaction_10444056", "reactome": "R-DME-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_209818", "species_351629" ], "products": [ "species_109276", "species_351630", "species_351628" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10442823": { "compartment": "compartment_876", "id": "reaction_10442823", "reactome": "R-DME-209910", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10442820", "catalyst" ] ], "additional_components": [ "P83740", "FBgn0052669", "Q8SWV5", "FBgn0034494" ] }, "reaction_10442839": { "compartment": "compartment_984", "id": "reaction_10442839", "reactome": "R-DME-209960", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_352329" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10442830", "catalyst" ] ], "additional_components": [ "Q9VTE7", "FBgn0036125", "species_76629" ] }, "reaction_10442758": { "compartment": "compartment_984", "id": "reaction_10442758", "reactome": "R-DME-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351630", "species_352030" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10442837": { "compartment": "compartment_984", "id": "reaction_10442837", "reactome": "R-DME-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329", "species_351639" ], "products": [ "species_352331", "species_352036" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10442833": { "compartment": "compartment_984", "id": "reaction_10442833", "reactome": "R-DME-209921", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351639" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10442830", "catalyst" ] ], "additional_components": [ "Q9VTE7", "FBgn0036125", "species_76629" ] }, "reaction_10442808": { "compartment": "compartment_1462052", "id": "reaction_10442808", "reactome": "R-DME-209891", "name": "Dopamine is oxidised to noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351595", "species_351593", "species_351601" ], "products": [ "species_351599", "species_351597", "species_351603" ], "modifiers": [ [ "species_10442805", "catalyst" ] ], "additional_components": [ "CHEBI:28694", "Q86B61", "FBgn0010329", "CHEBI:18315" ] }, "reaction_10442835": { "compartment": "compartment_70101", "id": "reaction_10442835", "reactome": "R-DME-209924", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209849" ], "products": [ "species_113528", "species_159362" ], "modifiers": [ [ "species_10442795", "catalyst" ] ], "additional_components": [ "P05031", "FBgn0000422" ] }, "reaction_10442768": { "compartment": "compartment_70101", "id": "reaction_10442768", "reactome": "R-DME-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29506" ], "products": [ "species_209849", "species_71112" ], "modifiers": [ [ "species_10442765", "catalyst" ] ], "additional_components": [ "P18459", "FBgn0005626", "species_111793" ] }, "reaction_10443240": { "compartment": "compartment_17960", "id": "reaction_10443240", "reactome": "R-DME-211962", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_216621", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216612" ], "modifiers": [ [ "species_10443237", "catalyst" ] ], "additional_components": [ "Q27589", "FBgn0011576" ] }, "reaction_10443235": { "compartment": "compartment_17960", "id": "reaction_10443235", "reactome": "R-DME-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10443232", "catalyst" ] ], "additional_components": [ "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10443248": { "compartment": "compartment_17960", "id": "reaction_10443248", "reactome": "R-DME-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10443245", "catalyst" ] ], "additional_components": [ "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10443226": { "compartment": "compartment_5460", "id": "reaction_10443226", "reactome": "R-DME-211950", "name": "CYP24A1 24-hydroxylates CTL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_215607", "species_113600" ], "products": [ "species_113563", "species_215622", "species_113521" ], "modifiers": [ [ "species_10442747", "catalyst" ] ], "additional_components": [ "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053" ] }, "reaction_10442787": { "compartment": "compartment_70101", "id": "reaction_10442787", "reactome": "R-DME-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10442784", "catalyst" ] ], "additional_components": [ "FBgn0004959" ] }, "reaction_10443163": { "compartment": "compartment_12045", "id": "reaction_10443163", "reactome": "R-DME-211873", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266056", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2161636" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10472838": { "compartment": "compartment_12045", "id": "reaction_10472838", "reactome": "R-DME-5602295", "name": "CYP4F22 20-hydroxylates TrXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2142713", "species_29368", "species_29364" ], "products": [ "species_5602281", "species_29356", "species_29366" ], "modifiers": [ [ "species_10433053", "catalyst" ] ], "additional_components": [ "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397" ] }, "reaction_10443219": { "compartment": "compartment_17960", "id": "reaction_10443219", "reactome": "R-DME-211919", "name": "CYP4F8 19-hydroxylates PGH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30138", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215545" ], "modifiers": [ [ "species_10443216", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10443328": { "compartment": "compartment_17960", "id": "reaction_10443328", "reactome": "R-DME-215526", "name": "CYP4F3 20-hydroxylates LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215557", "species_113601" ], "products": [ "species_113519", "species_113564", "species_571314" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10435630": { "compartment": "compartment_70101", "id": "reaction_10435630", "reactome": "R-DME-158447", "name": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430485", "species_10435624" ], "products": [ "species_10432289", "species_10432313", "species_10435628" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "FBgn0003321", "FBgn0010774", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10433293": { "compartment": "compartment_7660", "id": "reaction_10433293", "reactome": "R-DME-77594", "name": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433289", "species_10429500", "species_10432253" ], "products": [ "species_10429169", "species_10433291", "species_10429982" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "FBgn0010774", "FBgn0003321", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435626": { "compartment": "compartment_13231", "id": "reaction_10435626", "reactome": "R-DME-158441", "name": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433291" ], "products": [ "species_10435624" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435660": { "compartment": "compartment_70101", "id": "reaction_10435660", "reactome": "R-DME-158484", "name": "Release of the SLBP independent Histone mRNA from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430485", "species_10435654" ], "products": [ "species_10432289", "species_10432313", "species_10435658" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "FBgn0003321", "FBgn0010774", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10434122": { "compartment": "compartment_7660", "id": "reaction_10434122", "reactome": "R-DME-111439", "name": "Docking of Mature Histone mRNA complex:TAP at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434114", "species_10429500", "species_10432253" ], "products": [ "species_10429169", "species_10434120" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "FBgn0010774", "FBgn0003321", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435656": { "compartment": "compartment_13231", "id": "reaction_10435656", "reactome": "R-DME-158481", "name": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434120" ], "products": [ "species_10435654" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10450430": { "compartment": "compartment_70101", "id": "reaction_10450430", "reactome": "R-DME-446185", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449703" ], "products": [ "species_532204" ], "modifiers": [ [ "species_10450427", "catalyst" ] ], "additional_components": [ "FBgn0036298" ] }, "reaction_10485958": { "compartment": "compartment_70101", "id": "reaction_10485958", "reactome": "R-DME-6803789", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6803743" ], "products": [ "species_193473", "species_449701" ], "modifiers": [ [ "species_10485955", "catalyst" ] ], "additional_components": [ "FBgn0031099" ] }, "reaction_10450504": { "compartment": "compartment_70101", "id": "reaction_10450504", "reactome": "R-DME-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_532204" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10450501", "catalyst" ] ], "additional_components": [ "Q9Y0Z0", "FBgn0259749" ] }, "reaction_10450806": { "compartment": "compartment_70101", "id": "reaction_10450806", "reactome": "R-DME-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10450803", "catalyst" ] ], "additional_components": [ "Q9VAW3", "FBgn0039580", "Q7PLC7", "FBgn0287209" ] }, "reaction_10485950": { "compartment": "compartment_70101", "id": "reaction_10485950", "reactome": "R-DME-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803785", "species_113592" ], "products": [ "species_6803738", "species_70106", "species_29370" ], "modifiers": [ [ "species_10485947", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "species_449703", "species_6803743", "Q9VF86", "FBgn0038321" ] }, "reaction_10450816": { "compartment": "compartment_70101", "id": "reaction_10450816", "reactome": "R-DME-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_449701" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10450813", "catalyst" ] ], "additional_components": [ "Q9VAI0", "FBgn0039690" ] }, "reaction_10457936": { "compartment": "compartment_1222693", "id": "reaction_10457936", "reactome": "R-DME-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10457933", "catalyst" ] ], "additional_components": [ "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "P23380", "FBgn0262736" ] }, "reaction_10465115": { "compartment": "compartment_12045", "id": "reaction_10465115", "reactome": "R-DME-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10465112", "catalyst" ] ], "additional_components": [ "Q9VXY0", "FBgn0030615", "Q9V557", "FBgn0033395", "Q9VLZ7", "FBgn0031925", "O46051", "FBgn0023541", "Q9VVN6", "FBgn0036778", "Q9V4T5", "FBgn0015034", "Q9VL92", "FBgn0015035", "Q9VS79", "FBgn0015033", "Q9V4T3", "FBgn0033292", "Q9VGH1", "FBgn0003312", "Q9VS78", "FBgn0035790", "Q27606", "FBgn0014469", "Q9V7G5", "FBgn0034053", "Q9VMS9", "FBgn0031693", "Q27589", "FBgn0011576", "Q9W011", "FBgn0035344", "Q9V559", "FBgn0033397", "Q9VMS8", "FBgn0031694", "P33269", "FBgn0005670", "Q9VYQ7", "FBgn0030367", "Q9V558", "FBgn0015037", "Q9VMS7", "FBgn0031695", "O46054", "FBgn0015036", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10465105": { "compartment": "compartment_12045", "id": "reaction_10465105", "reactome": "R-DME-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10465102", "catalyst" ] ], "additional_components": [ "Q9VXY0", "FBgn0030615", "Q9V557", "FBgn0033395", "Q9VLZ7", "FBgn0031925", "O46051", "FBgn0023541", "Q9VVN6", "FBgn0036778", "Q9V4T5", "FBgn0015034", "Q9VL92", "FBgn0015035", "Q9VS79", "FBgn0015033", "Q9V4T3", "FBgn0033292", "Q9VGH1", "FBgn0003312", "Q9VS78", "FBgn0035790", "Q27606", "FBgn0014469", "Q9V7G5", "FBgn0034053", "Q9VMS9", "FBgn0031693", "Q27589", "FBgn0011576", "Q9W011", "FBgn0035344", "Q9V559", "FBgn0033397", "Q9VMS8", "FBgn0031694", "P33269", "FBgn0005670", "Q9VYQ7", "FBgn0030367", "Q9V558", "FBgn0015037", "Q9VMS7", "FBgn0031695", "O46054", "FBgn0015036", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_350385": { "compartment": "compartment_876", "id": "reaction_350385", "reactome": "R-DME-350385", "name": "DSH binds to RAC1:GTP", "reversible": "false", "notes": "The DEP domain of Dishevelled (DSH) binds to activated Rac GTPase (RAC1:GTP).", "reactants": [ "species_351067", "species_450734" ], "products": [ "species_450786" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "P40792", "RAC1_DROME", "species_29438", "A1Z6W3", "PK" ] }, "reaction_450723": { "compartment": "compartment_70101", "id": "reaction_450723", "reactome": "R-DME-450723", "name": "RAC1:GTP and MSN activate HEP", "reversible": "false", "notes": "Activated RAC1:GTP and the MAP kinase kinase kinase kinase (MKKKK) orthologue Misshapen (MSN) are involved in phosphorylating and activating the MKK orthologue Hemipterous (HEP). It is likely that a MKKK orthologue, currently unknown, is involved in directly phosphorylating HEP.", "reactants": [ "species_113592", "species_206293" ], "products": [ "species_29370", "species_205776" ], "modifiers": [ [ "species_450710", "catalyst" ], [ "species_450786", "catalyst" ] ], "additional_components": [ "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "P40792", "RAC1_DROME", "species_29438", "A1Z6W3", "PK" ] }, "reaction_10450527": { "compartment": "compartment_12045", "id": "reaction_10450527", "reactome": "R-DME-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10450524", "catalyst" ] ], "additional_components": [ "FBgn0035401" ] }, "reaction_10450543": { "compartment": "compartment_17957", "id": "reaction_10450543", "reactome": "R-DME-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449315" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10450540", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0039293", "FBgn0031662" ] }, "reaction_10450494": { "compartment": "compartment_17957", "id": "reaction_10450494", "reactome": "R-DME-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10450491", "catalyst" ] ], "additional_components": [ "FBgn0032234" ] }, "reaction_10450535": { "compartment": "compartment_12045", "id": "reaction_10450535", "reactome": "R-DME-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_29410" ], "products": [ "species_532214", "species_110096" ], "modifiers": [ [ "species_10450532", "catalyst" ] ], "additional_components": [ "FBgn0261020" ] }, "reaction_10486907": { "compartment": "compartment_70101", "id": "reaction_10486907", "reactome": "R-DME-6810464", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410" ], "products": [ "species_29548", "species_109402" ], "modifiers": [ [ "species_10486904", "catalyst" ] ], "additional_components": [ "FBgn0261995" ] }, "reaction_10479928": { "compartment": "compartment_70101", "id": "reaction_10479928", "reactome": "R-DME-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10479925", "catalyst" ] ], "additional_components": [ "Q9W1X8", "FBgn0267823" ] }, "reaction_10479939": { "compartment": "compartment_70101", "id": "reaction_10479939", "reactome": "R-DME-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6787646", "species_29364" ], "products": [ "species_742368", "species_29366" ], "modifiers": [ [ "species_10479925", "catalyst" ] ], "additional_components": [ "Q9W1X8", "FBgn0267823" ] }, "reaction_10479936": { "compartment": "compartment_70101", "id": "reaction_10479936", "reactome": "R-DME-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_29356", "species_6787618" ], "modifiers": [ [ "species_10479933", "catalyst" ] ], "additional_components": [ "FBgn0031661" ] }, "reaction_10469805": { "compartment": "compartment_12045", "id": "reaction_10469805", "reactome": "R-DME-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10469802", "catalyst" ] ], "additional_components": [ "FBgn0032014" ] }, "reaction_10469797": { "compartment": "compartment_12045", "id": "reaction_10469797", "reactome": "R-DME-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_4419987" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10469794", "catalyst" ] ], "additional_components": [ "Q9W3M6", "FBgn0029980", "Q9VPX8", "FBgn0031312" ] }, "reaction_10450468": { "compartment": "compartment_12045", "id": "reaction_10450468", "reactome": "R-DME-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_449221" ], "products": [ "species_110094", "species_449299" ], "modifiers": [ [ "species_10450465", "catalyst" ] ], "additional_components": [ "FBgn0034141" ] }, "reaction_10450460": { "compartment": "compartment_12045", "id": "reaction_10450460", "reactome": "R-DME-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449299" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10450457", "catalyst" ] ], "additional_components": [ "FBgn0032477" ] }, "reaction_10450476": { "compartment": "compartment_17957", "id": "reaction_10450476", "reactome": "R-DME-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449312" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10450473", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0037743", "FBgn0031662" ] }, "reaction_10450443": { "compartment": "compartment_17957", "id": "reaction_10450443", "reactome": "R-DME-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449298" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10450435", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0011297", "FBgn0031662" ] }, "reaction_10450553": { "compartment": "compartment_12045", "id": "reaction_10450553", "reactome": "R-DME-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_29420", "species_449283" ], "modifiers": [ [ "species_10450550", "catalyst" ] ], "additional_components": [ "FBgn0038552" ] }, "reaction_10450519": { "compartment": "compartment_12045", "id": "reaction_10450519", "reactome": "R-DME-446207", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449222" ], "products": [ "species_449293", "species_110096" ], "modifiers": [ [ "species_10450516", "catalyst" ] ], "additional_components": [ "Q9VAP1", "FBgn0039639", "Q9VXU7", "FBgn0030645" ] }, "reaction_10450452": { "compartment": "compartment_17957", "id": "reaction_10450452", "reactome": "R-DME-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10450449", "catalyst" ] ], "additional_components": [ "FBgn0029906" ] }, "reaction_10450545": { "compartment": "compartment_17957", "id": "reaction_10450545", "reactome": "R-DME-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449371", "species_449311" ], "modifiers": [ [ "species_10450540", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0039293", "FBgn0031662" ] }, "reaction_10435743": { "compartment": "compartment_7660", "id": "reaction_10435743", "reactome": "R-DME-159101", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435738", "species_10432271" ], "products": [ "species_113550", "species_10432277", "species_10435740" ], "modifiers": [ [ "species_10435738", "catalyst" ] ], "additional_components": [ "Q02427", "FBgn0260944", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q9V3V0", "FBgn0028554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q9U1H9", "FBgn0003321", "Q9VV73", "FBgn0036640", "Q8IQK4", "FBgn0263232", "Q9V3H8", "FBgn0028411", "Q9U1H9", "FBgn0003321", "Q9VV73", "FBgn0036640", "Q8IQK4", "FBgn0263232", "Q9V3H8", "FBgn0028411", "Q02427", "FBgn0260944", "Q9VD52", "FBgn0038927", "Q9V3T8", "FBgn0265298", "Q9VY54", "FBgn0026713", "P26686", "FBgn0004587", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9V3E7", "FBgn0010774", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q27268", "FBgn0014189", "species_29370", "Q02427", "FBgn0260944", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q9V3V0", "FBgn0028554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411" ] }, "reaction_10432342": { "compartment": "compartment_70101", "id": "reaction_10432342", "reactome": "R-DME-75098", "name": "mRNP complex dissociates from cytosolic face of NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432329" ], "products": [ "species_10432243", "species_10432340", "species_10432301" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3H8", "FBgn0028411", "Q9VV73", "FBgn0036640", "Q9U1H9", "FBgn0003321", "Q8IQK4", "FBgn0263232", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VHC0", "FBgn0037707", "Q9V3E7", "FBgn0010774", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VHC0", "FBgn0037707", "Q9V3E7", "FBgn0010774", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3H8", "FBgn0028411", "Q9VV73", "FBgn0036640", "Q9U1H9", "FBgn0003321", "Q8IQK4", "FBgn0263232", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10432336": { "compartment": "compartment_13231", "id": "reaction_10432336", "reactome": "R-DME-75097", "name": "Transport of the export-competent mRNP complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432279" ], "products": [ "species_10432329" ], "modifiers": [ [ "species_10432243", "catalyst" ], [ "species_10432334", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9VV73", "FBgn0036640", "Q8IQK4", "FBgn0263232", "Q9V3H8", "FBgn0028411", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3H8", "FBgn0028411", "Q9VV73", "FBgn0036640", "Q9U1H9", "FBgn0003321", "Q8IQK4", "FBgn0263232", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VHC0", "FBgn0037707", "Q9V3E7", "FBgn0010774", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "FBgn0033316" ] }, "reaction_10439582": { "compartment": "compartment_17927", "id": "reaction_10439582", "reactome": "R-DME-189421", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189411" ], "products": [ "species_189481", "species_189480", "species_189478" ], "modifiers": [ [ "species_10439579", "catalyst" ] ], "additional_components": [ "Q9V3D2", "FBgn0021944" ] }, "reaction_10467261": { "compartment": "compartment_5460", "id": "reaction_10467261", "reactome": "R-DME-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10467258", "catalyst" ] ], "additional_components": [ "FBgn0034938" ] }, "reaction_10439612": { "compartment": "compartment_70101", "id": "reaction_10439612", "reactome": "R-DME-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_29356", "species_70106", "species_189464" ], "modifiers": [ [ "species_10439609", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VTV9", "FBgn0036271" ] }, "reaction_10439640": { "compartment": "compartment_5460", "id": "reaction_10439640", "reactome": "R-DME-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_113529", "species_189444" ], "modifiers": [ [ "species_10439637", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "Q9V9S8", "FBgn0266268" ] }, "reaction_10455127": { "compartment": "compartment_876", "id": "reaction_10455127", "reactome": "R-DME-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_71185" ], "products": [ "species_29372", "species_917877", "species_29370" ], "modifiers": [ [ "species_10455124", "catalyst" ] ], "additional_components": [ "P45843", "FBgn0003515", "P12428", "FBgn0000241", "Q0KI14", "FBgn0051121" ] }, "reaction_10467253": { "compartment": "compartment_5460", "id": "reaction_10467253", "reactome": "R-DME-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10467250", "catalyst" ] ], "additional_components": [ "FBgn0032222" ] }, "reaction_10439572": { "compartment": "compartment_70101", "id": "reaction_10439572", "reactome": "R-DME-189406", "name": "4 PBGs bind to form HMB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_189464" ], "products": [ "species_189449", "species_31633" ], "modifiers": [ [ "species_10439569", "catalyst" ] ], "additional_components": [ "Q9W0G4", "FBgn0010786", "CHEBI:36319" ] }, "reaction_10439602": { "compartment": "compartment_70101", "id": "reaction_10439602", "reactome": "R-DME-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_189455", "species_113528" ], "modifiers": [ [ "species_10439599", "catalyst" ] ], "additional_components": [ "Q9V595", "FBgn0033428" ] }, "reaction_10439630": { "compartment": "compartment_5460", "id": "reaction_10439630", "reactome": "R-DME-189442", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_70958", "species_113529" ], "products": [ "species_29374", "species_189466", "species_29376" ], "modifiers": [ [ "species_10439627", "catalyst" ], [ "species_189444", "inhibitor" ] ], "additional_components": [ "O18680", "FBgn0020764" ] }, "reaction_10439592": { "compartment": "compartment_17927", "id": "reaction_10439592", "reactome": "R-DME-189423", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189478" ], "products": [ "species_189481", "species_189463" ], "modifiers": [ [ "species_10439589", "catalyst" ] ], "additional_components": [ "Q9VC52", "FBgn0020018", "species_113596" ] }, "reaction_10439654": { "compartment": "compartment_70101", "id": "reaction_10439654", "reactome": "R-DME-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10439599", "catalyst" ] ], "additional_components": [ "Q9V595", "FBgn0033428" ] }, "reaction_10439652": { "compartment": "compartment_70101", "id": "reaction_10439652", "reactome": "R-DME-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10439609" ], "products": [ "species_10439650", "species_29426" ], "modifiers": [], "additional_components": [ "species_1562550", "Q9VTV9", "FBgn0036271", "species_1562550", "Q9VTV9", "FBgn0036271", "species_190173" ] }, "reaction_10439648": { "compartment": "compartment_70101", "id": "reaction_10439648", "reactome": "R-DME-189488", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189449" ], "products": [ "species_189407", "species_29356" ], "modifiers": [ [ "species_10439645", "catalyst" ] ], "additional_components": [ "FBgn0030066" ] }, "reaction_10453037": { "compartment": "compartment_876", "id": "reaction_10453037", "reactome": "R-DME-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10453034", "catalyst" ] ], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "Q8IRI6", "FBgn0264574" ] }, "reaction_10447180": { "compartment": "compartment_876", "id": "reaction_10447180", "reactome": "R-DME-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10447177", "catalyst" ] ], "additional_components": [ "species_29438" ] }, "reaction_10443692": { "compartment": "compartment_876", "id": "reaction_10443692", "reactome": "R-DME-265645", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10443689", "catalyst" ] ], "additional_components": [ "X2J9Z3", "FBgn0028863", "Q8IP22", "FBgn0261999", "Q24270", "FBgn0001991", "P91645", "FBgn0263111" ] }, "reaction_10449645": { "compartment": "compartment_876", "id": "reaction_10449645", "reactome": "R-DME-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10449642", "catalyst" ] ], "additional_components": [ "FBgn0035815" ] }, "reaction_10447214": { "compartment": "compartment_876", "id": "reaction_10447214", "reactome": "R-DME-400092", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447212" ], "products": [ "species_29420", "species_10447204" ], "modifiers": [ [ "species_10445696", "catalyst" ] ], "additional_components": [ "species_29420", "species_29438", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10447208": { "compartment": "compartment_876", "id": "reaction_10447208", "reactome": "R-DME-400071", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10445692" ], "products": [ "species_10445696" ], "modifiers": [], "additional_components": [ "CHEBI:28918", "species_351597", "FBgn0004514", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10447206": { "compartment": "compartment_876", "id": "reaction_10447206", "reactome": "R-DME-400037", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447204" ], "products": [ "species_10447202", "species_10447196" ], "modifiers": [], "additional_components": [ "species_29438", "species_29438" ] }, "reaction_10447221": { "compartment": "compartment_876", "id": "reaction_10447221", "reactome": "R-DME-400097", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447217", "species_10447202" ], "products": [ "species_10447219" ], "modifiers": [], "additional_components": [] }, "reaction_10446063": { "compartment": "compartment_70101", "id": "reaction_10446063", "reactome": "R-DME-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10446061" ], "products": [ "species_29420", "species_10444262" ], "modifiers": [ [ "species_10446032", "catalyst" ], [ "species_10446001", "catalyst" ] ], "additional_components": [ "species_29420", "P08645", "FBgn0004636", "P08645", "FBgn0004636", "species_29438", "A1Z6P8", "FBgn0085421", "species_30389", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10446059": { "compartment": "compartment_876", "id": "reaction_10446059", "reactome": "R-DME-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446057" ], "products": [ "species_10446057" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "P17970", "FBgn0262593", "P17972", "FBgn0003386", "A8DYR5", "FBgn0085395", "P17970", "FBgn0262593", "P17972", "FBgn0003386", "A8DYR5", "FBgn0085395", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10446027": { "compartment": "compartment_12045", "id": "reaction_10446027", "reactome": "R-DME-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446017" ], "products": [ "species_10446025" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "P29993", "FBgn0010051", "P29993", "FBgn0010051", "species_114520", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10446003": { "compartment": "compartment_876", "id": "reaction_10446003", "reactome": "R-DME-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10445999" ], "products": [ "species_10446001" ], "modifiers": [], "additional_components": [ "FBgn0085421", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10446034": { "compartment": "compartment_876", "id": "reaction_10446034", "reactome": "R-DME-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10446030" ], "products": [ "species_10446032" ], "modifiers": [], "additional_components": [ "FBgn0085421", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10430876": { "compartment": "compartment_70101", "id": "reaction_10430876", "reactome": "R-DME-73567", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111294", "species_111629" ], "modifiers": [ [ "species_10430870", "catalyst" ] ], "additional_components": [ "Q01637", "FBgn0003257" ] }, "reaction_10430873": { "compartment": "compartment_70101", "id": "reaction_10430873", "reactome": "R-DME-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10430870", "catalyst" ] ], "additional_components": [ "Q01637", "FBgn0003257" ] }, "reaction_10430902": { "compartment": "compartment_70101", "id": "reaction_10430902", "reactome": "R-DME-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592", "species_29472" ], "products": [ "species_111647", "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10430893", "catalyst" ] ], "additional_components": [ "P05990", "FBgn0003189" ] }, "reaction_10430886": { "compartment": "compartment_70101", "id": "reaction_10430886", "reactome": "R-DME-73569", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_76630" ], "products": [ "species_76632", "species_76633" ], "modifiers": [ [ "species_10430883", "catalyst" ] ], "additional_components": [ "species_76629", "P32748", "FBgn0000447" ] }, "reaction_10430899": { "compartment": "compartment_70101", "id": "reaction_10430899", "reactome": "R-DME-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111647", "species_29448" ], "products": [ "species_111628", "species_29372" ], "modifiers": [ [ "species_10430893", "catalyst" ] ], "additional_components": [ "P05990", "FBgn0003189" ] }, "reaction_10430896": { "compartment": "compartment_70101", "id": "reaction_10430896", "reactome": "R-DME-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111628", "species_70106" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10430893", "catalyst" ] ], "additional_components": [ "P05990", "FBgn0003189" ] }, "reaction_10490053": { "compartment": "compartment_7660", "id": "reaction_10490053", "reactome": "R-DME-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567" ], "modifiers": [ [ "species_10490050", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "Q9VVY4", "FBgn0028380", "species_1562550" ] }, "reaction_10430942": { "compartment": "compartment_70101", "id": "reaction_10430942", "reactome": "R-DME-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73588" ], "products": [ "species_113528", "species_73590", "species_31633" ], "modifiers": [ [ "species_10430939", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VI04", "FBgn0037513" ] }, "reaction_10430974": { "compartment": "compartment_70101", "id": "reaction_10430974", "reactome": "R-DME-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83960", "species_29364" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10430919", "catalyst" ] ], "additional_components": [ "species_76629", "Q9W374", "FBgn0086450", "species_113596" ] }, "reaction_10431581": { "compartment": "compartment_70101", "id": "reaction_10431581", "reactome": "R-DME-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_83962", "species_500244" ], "modifiers": [ [ "species_10431576", "catalyst" ] ], "additional_components": [ "CHEBI:16450", "CHEBI:16704", "CHEBI:28542", "species_112016", "Q9VBA0", "FBgn0039464", "Q8T8S2", "FBgn0034800", "Q0E8U4", "FBgn0031489" ] }, "reaction_10433355": { "compartment": "compartment_70101", "id": "reaction_10433355", "reactome": "R-DME-109449", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10433352", "catalyst" ] ], "additional_components": [ "species_1524067", "CHEBI:15918", "species_109366", "species_109382", "species_418075", "CHEBI:15698", "CHEBI:16450", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_29926", "Q9W197", "FBgn0034988" ] }, "reaction_10430922": { "compartment": "compartment_70101", "id": "reaction_10430922", "reactome": "R-DME-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83962", "species_29364" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10430919", "catalyst" ] ], "additional_components": [ "species_76629", "Q9W374", "FBgn0086450", "species_113596" ] }, "reaction_10433333": { "compartment": "compartment_984", "id": "reaction_10433333", "reactome": "R-DME-109291", "name": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_500316" ], "products": [ "species_109277", "species_500318" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_418075", "species_1524067", "species_109366", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10430932": { "compartment": "compartment_70101", "id": "reaction_10430932", "reactome": "R-DME-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_73588" ], "modifiers": [ [ "species_10430929", "catalyst" ] ], "additional_components": [ "Q8IPQ2", "FBgn0023023", "species_1562550" ] }, "reaction_10430978": { "compartment": "compartment_70101", "id": "reaction_10430978", "reactome": "R-DME-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73617" ], "products": [ "species_113528", "species_73619", "species_31633" ], "modifiers": [ [ "species_10430939", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VI04", "FBgn0037513" ] }, "reaction_10430976": { "compartment": "compartment_70101", "id": "reaction_10430976", "reactome": "R-DME-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73541" ], "products": [ "species_73617" ], "modifiers": [ [ "species_10430929", "catalyst" ] ], "additional_components": [ "Q8IPQ2", "FBgn0023023", "species_1562550" ] }, "reaction_10488423": { "compartment": "compartment_984", "id": "reaction_10488423", "reactome": "R-DME-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8936165" ], "products": [ "species_8851369", "species_109277" ], "modifiers": [ [ "species_10488420", "catalyst" ] ], "additional_components": [ "species_29370", "species_205687", "species_29420", "species_110094", "species_418075", "species_1524067", "species_5696194", "species_76577", "M9PBV2", "FBgn0024947", "species_29926", "species_74016" ] }, "reaction_10488430": { "compartment": "compartment_984", "id": "reaction_10488430", "reactome": "R-DME-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8851462" ], "products": [ "species_109277", "species_8851461" ], "modifiers": [ [ "species_10488427", "catalyst" ] ], "additional_components": [ "CHEBI:17808", "species_205687", "species_29420", "species_110094", "species_418075", "species_29602", "species_1524067", "species_5696194", "species_29926", "species_74016", "M9PBV2", "FBgn0024947" ] }, "reaction_10498277": { "compartment": "compartment_17957", "id": "reaction_10498277", "reactome": "R-DME-9650473", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498275" ], "products": [ "species_10452491" ], "modifiers": [], "additional_components": [ "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930" ] }, "reaction_10472854": { "compartment": "compartment_984", "id": "reaction_10472854", "reactome": "R-DME-5607023", "name": "factor IXa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435383" ], "products": [ "species_10472852" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10498442": { "compartment": "compartment_17957", "id": "reaction_10498442", "reactome": "R-DME-9670673", "name": "FIX is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498440" ], "products": [ "species_10435369" ], "modifiers": [], "additional_components": [ "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459" ] }, "reaction_10478063": { "compartment": "compartment_984", "id": "reaction_10478063", "reactome": "R-DME-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_83908" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10478060", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VVK5", "FBgn0036752" ] }, "reaction_10497731": { "compartment": "compartment_12045", "id": "reaction_10497731", "reactome": "R-DME-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497729" ], "products": [ "species_10476466" ], "modifiers": [], "additional_components": [ "FBgn0000416", "FBgn0000416" ] }, "reaction_10476537": { "compartment": "compartment_3828046", "id": "reaction_10476537", "reactome": "R-DME-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476466", "species_5685882" ], "products": [ "species_10476468", "species_10476470", "species_10476472" ], "modifiers": [ [ "species_10476534", "catalyst" ] ], "additional_components": [ "FBgn0000416", "FBgn0000416", "FBgn0000416", "FBgn0000416", "Q9VLK3", "FBgn0032049", "Q9VKP7", "FBgn0032303", "Q9VKP6", "FBgn0032304", "Q9VEK4", "FBgn0038506", "Q9W5G3", "FBgn0011822", "Q9VEK3", "FBgn0038507", "Q9VQ14", "FBgn0053128", "Q7K485", "FBgn0029093", "Q9VQ13", "FBgn0051926", "A1Z9Q9", "FBgn0033933", "Q9VQ12", "FBgn0053128", "Q9VQ11", "FBgn0051928", "Q9VNK6", "FBgn0037396" ] }, "reaction_10480360": { "compartment": "compartment_3828046", "id": "reaction_10480360", "reactome": "R-DME-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476468" ], "products": [ "species_10476539" ], "modifiers": [], "additional_components": [ "FBgn0000416", "Q9Y125", "FBgn0000416" ] }, "reaction_10476405": { "compartment": "compartment_7660", "id": "reaction_10476405", "reactome": "R-DME-5683888", "name": "LMCD1 binds GATA6, sequestering it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476401", "species_10457526" ], "products": [ "species_10476403" ], "modifiers": [], "additional_components": [ "FBgn0034223", "Q9VF00", "FBgn0038391", "P52168", "FBgn0003117", "Q9VF00", "FBgn0038391", "P52168", "FBgn0003117", "A1ZAT5", "FBgn0034223" ] }, "reaction_10498522": { "compartment": "compartment_7660", "id": "reaction_10498522", "reactome": "R-DME-9679787", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498518", "species_9679795" ], "products": [ "species_10498520" ], "modifiers": [], "additional_components": [ "Q9VXB3", "FBgn0030788", "Q94517", "HDAC1", "Q9VWP5", "FBgn0085451", "Q9VWG2", "FBgn0031036", "Q9VEX9", "FBgn0024491", "Q24572", "FBgn0263979", "Q9VYI2", "FBgn0030434", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397", "Q9VK36", "FBgn0032473", "Q8T092", "FBgn0034114", "Q9VRV0", "FBgn0035687", "Q9VH18", "FBgn0037794", "Q9W137", "FBgn0035036", "Q9VIS9", "FBgn0032814", "A1ZBC5", "FBgn0034379", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q9VXB3", "FBgn0030788", "Q94517", "HDAC1", "Q9VWP5", "FBgn0085451", "Q9VWG2", "FBgn0031036", "Q9VEX9", "FBgn0024491", "Q24572", "FBgn0263979", "Q9VYI2", "FBgn0030434", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397", "Q9VK36", "FBgn0032473", "Q8T092", "FBgn0034114", "Q9VRV0", "FBgn0035687", "Q9VH18", "FBgn0037794", "Q9W137", "FBgn0035036", "Q9VIS9", "FBgn0032814", "A1ZBC5", "FBgn0034379", "O97159", "FBgn0262519", "O16102", "FBgn0023395" ] }, "reaction_10461614": { "compartment": "compartment_7660", "id": "reaction_10461614", "reactome": "R-DME-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461741": { "compartment": "compartment_7660", "id": "reaction_10461741", "reactome": "R-DME-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461580": { "compartment": "compartment_7660", "id": "reaction_10461580", "reactome": "R-DME-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10461577", "catalyst" ] ], "additional_components": [ "FBgn0050295" ] }, "reaction_10461738": { "compartment": "compartment_7660", "id": "reaction_10461738", "reactome": "R-DME-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023892" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461658": { "compartment": "compartment_7660", "id": "reaction_10461658", "reactome": "R-DME-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461529": { "compartment": "compartment_7660", "id": "reaction_10461529", "reactome": "R-DME-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461655": { "compartment": "compartment_7660", "id": "reaction_10461655", "reactome": "R-DME-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461747": { "compartment": "compartment_7660", "id": "reaction_10461747", "reactome": "R-DME-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461729": { "compartment": "compartment_7660", "id": "reaction_10461729", "reactome": "R-DME-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461632": { "compartment": "compartment_7660", "id": "reaction_10461632", "reactome": "R-DME-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023935" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461567": { "compartment": "compartment_70101", "id": "reaction_10461567", "reactome": "R-DME-1855166", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023943" ], "products": [ "species_29372", "species_994141" ], "modifiers": [ [ "species_10461555", "catalyst" ] ], "additional_components": [ "species_1629736", "species_2023922", "CHEBI:62927", "species_29926", "species_266099", "Q7JVG2", "FBgn0036111" ] }, "reaction_10461726": { "compartment": "compartment_70101", "id": "reaction_10461726", "reactome": "R-DME-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461564": { "compartment": "compartment_70101", "id": "reaction_10461564", "reactome": "R-DME-1855165", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_1629765", "species_29372" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "species_2023931", "CHEBI:62924", "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10461624": { "compartment": "compartment_70101", "id": "reaction_10461624", "reactome": "R-DME-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10461619", "catalyst" ] ], "additional_components": [ "FBgn0027279" ] }, "reaction_10463703": { "compartment": "compartment_70101", "id": "reaction_10463703", "reactome": "R-DME-2023973", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_29372", "species_2023974" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "species_2023931", "CHEBI:62924", "species_2023932", "CHEBI:62922", "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10463701": { "compartment": "compartment_70101", "id": "reaction_10463701", "reactome": "R-DME-2023971", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023974" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "species_2023932", "CHEBI:62922", "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10461641": { "compartment": "compartment_70101", "id": "reaction_10461641", "reactome": "R-DME-1855198", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_29356" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10461608": { "compartment": "compartment_70101", "id": "reaction_10461608", "reactome": "R-DME-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10461605", "catalyst" ] ], "additional_components": [ "FBgn0050295" ] }, "reaction_10461735": { "compartment": "compartment_70101", "id": "reaction_10461735", "reactome": "R-DME-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461638": { "compartment": "compartment_70101", "id": "reaction_10461638", "reactome": "R-DME-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461701": { "compartment": "compartment_70101", "id": "reaction_10461701", "reactome": "R-DME-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10461619", "catalyst" ] ], "additional_components": [ "FBgn0027279" ] }, "reaction_10461635": { "compartment": "compartment_70101", "id": "reaction_10461635", "reactome": "R-DME-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461536": { "compartment": "compartment_70101", "id": "reaction_10461536", "reactome": "R-DME-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10442750": { "compartment": "compartment_70616", "id": "reaction_10442750", "reactome": "R-DME-209765", "name": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_209800", "species_29368", "species_29364" ], "products": [ "species_29356", "species_350159", "species_29366" ], "modifiers": [ [ "species_10442747", "catalyst" ], [ "species_29532", "catalyst" ] ], "additional_components": [ "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053" ] }, "reaction_10495353": { "compartment": "compartment_161320", "id": "reaction_10495353", "reactome": "R-DME-8963864", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495351" ], "products": [ "species_350136", "species_10495349" ], "modifiers": [], "additional_components": [ "A8JQY3", "FBgn0085431", "species_8963879", "FBgn0085431" ] }, "reaction_10495357": { "compartment": "compartment_7660", "id": "reaction_10495357", "reactome": "R-DME-8963915", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445234", "species_8963912" ], "products": [ "species_10495355" ], "modifiers": [], "additional_components": [ "FBgn0015240", "species_8963912", "Q24143", "FBgn0015240" ] }, "reaction_10460847": { "compartment": "compartment_70101", "id": "reaction_10460847", "reactome": "R-DME-1655831", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460835" ], "products": [ "species_10460845" ], "modifiers": [], "additional_components": [ "O18388", "FBgn0262743", "Q9VW37", "FBgn0261283", "Q9VW37", "FBgn0261283", "O18388", "FBgn0262743" ] }, "reaction_10464750": { "compartment": "compartment_70101", "id": "reaction_10464750", "reactome": "R-DME-2065549", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460827" ], "products": [ "species_10460833" ], "modifiers": [], "additional_components": [ "FBgn0261283", "Q9VW37", "FBgn0261283" ] }, "reaction_10464748": { "compartment": "compartment_7660", "id": "reaction_10464748", "reactome": "R-DME-2065539", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442310", "species_10460845" ], "products": [ "species_10464746", "species_10460843" ], "modifiers": [], "additional_components": [ "species_29438", "Q9VZ23", "FBgn0020255", "Q9VW37", "FBgn0261283", "O18388", "FBgn0262743", "O18388", "FBgn0262743", "species_29438", "Q9VZ23", "FBgn0020255", "Q9VW37", "FBgn0261283" ] }, "reaction_10460870": { "compartment": "compartment_20699", "id": "reaction_10460870", "reactome": "R-DME-1655851", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460862" ], "products": [ "species_10460827" ], "modifiers": [ [ "species_10447716", "catalyst" ] ], "additional_components": [ "FBgn0261283", "FBgn0261283", "FBgn0033656" ] }, "reaction_10460868": { "compartment": "compartment_20699", "id": "reaction_10460868", "reactome": "R-DME-1655842", "name": "S1P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460860" ], "products": [ "species_10460858", "species_10460862" ], "modifiers": [ [ "species_10445971", "catalyst" ] ], "additional_components": [ "A1Z6J2", "FBgn0033052", "Q9VW37", "FBgn0261283", "A1Z6J2", "FBgn0033052", "FBgn0261283", "FBgn0037105" ] }, "reaction_10464752": { "compartment": "compartment_70101", "id": "reaction_10464752", "reactome": "R-DME-2065550", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460833", "species_10443115" ], "products": [ "species_10460835" ], "modifiers": [], "additional_components": [ "Q9VW37", "FBgn0261283", "FBgn0262743", "O18388", "FBgn0262743", "Q9VW37", "FBgn0261283" ] }, "reaction_10446655": { "compartment": "compartment_17951", "id": "reaction_10446655", "reactome": "R-DME-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10446652", "catalyst" ] ], "additional_components": [ "FBgn0039131" ] }, "reaction_10487936": { "compartment": "compartment_12045", "id": "reaction_10487936", "reactome": "R-DME-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10446670": { "compartment": "compartment_17951", "id": "reaction_10446670", "reactome": "R-DME-390438", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10446667", "catalyst" ] ], "additional_components": [ "Q9VES6", "FBgn0038450", "Q9VES5", "FBgn0038451" ] }, "reaction_10487938": { "compartment": "compartment_12045", "id": "reaction_10487938", "reactome": "R-DME-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10479146": { "compartment": "compartment_12045", "id": "reaction_10479146", "reactome": "R-DME-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10479143", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10489409": { "compartment": "compartment_12045", "id": "reaction_10489409", "reactome": "R-DME-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489403", "species_549167" ], "products": [ "species_10489407" ], "modifiers": [], "additional_components": [ "FBgn0035586", "species_1500594", "Q9VRJ2", "FBgn0035586" ] }, "reaction_10489306": { "compartment": "compartment_13977", "id": "reaction_10489306", "reactome": "R-DME-8856630", "name": "CIDEA:CIDEC binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866926", "species_10489302" ], "products": [ "species_10489304" ], "modifiers": [], "additional_components": [ "species_1500594", "species_163579", "CHEBI:16247", "A8DY77", "FBgn0028408", "Q0E9B7", "FBgn0028407", "A8DY77", "FBgn0028408", "Q0E9B7", "FBgn0028407", "species_1500594", "species_163579", "CHEBI:16247" ] }, "reaction_10489517": { "compartment": "compartment_70101", "id": "reaction_10489517", "reactome": "R-DME-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866926", "species_10478095" ], "products": [ "species_10489515" ], "modifiers": [], "additional_components": [ "species_1500594", "species_163579", "CHEBI:16247", "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043", "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043", "species_1500594", "species_163579", "CHEBI:16247" ] }, "reaction_10465087": { "compartment": "compartment_12045", "id": "reaction_10465087", "reactome": "R-DME-2161745", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2161636" ], "products": [ "species_29356", "species_29366", "species_2142740" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10465100": { "compartment": "compartment_12045", "id": "reaction_10465100", "reactome": "R-DME-2161792", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2142740" ], "products": [ "species_2161582", "species_29356", "species_29366" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10443833": { "compartment": "compartment_876", "id": "reaction_10443833", "reactome": "R-DME-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10443830", "catalyst" ] ], "additional_components": [ "FBgn0032456" ] }, "reaction_10443764": { "compartment": "compartment_876", "id": "reaction_10443764", "reactome": "R-DME-266012", "name": "LTD4 is converted to LTE4 by DPEP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266074", "species_109276" ], "products": [ "species_266029", "species_266033" ], "modifiers": [ [ "species_10443761", "catalyst" ] ], "additional_components": [ "Q9VBG1", "FBgn0039420", "X2JCU8", "FBgn0266100", "Q9VPG0", "FBgn0036986", "Q9VJ94", "FBgn0261804", "species_1562550" ] }, "reaction_10443843": { "compartment": "compartment_70101", "id": "reaction_10443843", "reactome": "R-DME-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265281" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10443825": { "compartment": "compartment_876", "id": "reaction_10443825", "reactome": "R-DME-266046", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_266013" ], "products": [ "species_266074", "species_210382" ], "modifiers": [ [ "species_10443822", "catalyst" ] ], "additional_components": [ "Q9VYR2", "FBgn0030361", "Q9VWT3", "FBgn0030932", "Q7KUX2", "FBgn0030796", "M9NFP5", "FBgn0025837" ] }, "reaction_10465110": { "compartment": "compartment_12045", "id": "reaction_10465110", "reactome": "R-DME-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10432779", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10465108": { "compartment": "compartment_12045", "id": "reaction_10465108", "reactome": "R-DME-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10432779", "catalyst" ] ], "additional_components": [ "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10465126": { "compartment": "compartment_70101", "id": "reaction_10465126", "reactome": "R-DME-2161999", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142811", "species_29450" ], "products": [ "species_29356", "species_2142678", "species_111745" ], "modifiers": [ [ "species_10465121", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10465124": { "compartment": "compartment_70101", "id": "reaction_10465124", "reactome": "R-DME-2161959", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142790" ], "products": [ "species_29356", "species_2142716", "species_111745" ], "modifiers": [ [ "species_10465121", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10478161": { "compartment": "compartment_13977", "id": "reaction_10478161", "reactome": "R-DME-5693751", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693752", "species_5693747" ], "products": [ "species_5693736", "species_5693733" ], "modifiers": [ [ "species_10478158", "catalyst" ] ], "additional_components": [ "FBgn0033717" ] }, "reaction_10464589": { "compartment": "compartment_17957", "id": "reaction_10464589", "reactome": "R-DME-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10453288", "catalyst" ] ], "additional_components": [ "Q9VV87", "FBgn0260960", "Q9VHX7", "FBgn0037534", "Q6NN18", "FBgn0034382", "Q9VCY6", "FBgn0038986", "Q9VH59", "FBgn0037761", "Q4V3H4", "FBgn0037764", "Q9VCY5", "FBgn0053110", "Q9VH58", "FBgn0037762", "A1ZBD2", "FBgn0034383", "Q9VCT3", "FBgn0039030", "Q9VH57", "FBgn0037763", "Q95T98", "FBgn0051523", "Q9VH55", "FBgn0037765", "Q8SXD1", "FBgn0050008", "Q9VCZ0", "FBgn0038983", "Q8IMY2", "FBgn0051141", "Q9VCY7", "FBgn0260942" ] }, "reaction_10464587": { "compartment": "compartment_17957", "id": "reaction_10464587", "reactome": "R-DME-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10446277", "catalyst" ] ], "additional_components": [ "FBgn0039890" ] }, "reaction_10464779": { "compartment": "compartment_17951", "id": "reaction_10464779", "reactome": "R-DME-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_2046047" ], "products": [ "species_113575", "species_2066767" ], "modifiers": [ [ "species_10446616", "catalyst" ] ], "additional_components": [ "species_113596", "Q7KML2", "FBgn0027572" ] }, "reaction_10464777": { "compartment": "compartment_17951", "id": "reaction_10464777", "reactome": "R-DME-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10464775": { "compartment": "compartment_17951", "id": "reaction_10464775", "reactome": "R-DME-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066767" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10491976": { "compartment": "compartment_70616", "id": "reaction_10491976", "reactome": "R-DME-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491965", "species_977314" ], "products": [ "species_29374", "species_10491968" ], "modifiers": [ [ "species_10491973", "catalyst" ] ], "additional_components": [ "FBgn0011361", "FBgn0011361", "FBgn0036691" ] }, "reaction_10487865": { "compartment": "compartment_17957", "id": "reaction_10487865", "reactome": "R-DME-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10487859" ], "products": [ "species_10487863" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "FBgn0031992", "Q9VLS4", "FBgn0031992", "species_164991", "species_5690542" ] }, "reaction_10477557": { "compartment": "compartment_5460", "id": "reaction_10477557", "reactome": "R-DME-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10477554", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_30495", "species_5690531", "FBgn0039854" ] }, "reaction_10477541": { "compartment": "compartment_70101", "id": "reaction_10477541", "reactome": "R-DME-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10477538", "catalyst" ] ], "additional_components": [ "species_5690542", "species_164991", "species_5690531", "species_30495", "Q9VZZ6", "FBgn0035355", "Q9VZZ5", "FBgn0035356" ] }, "reaction_10491084": { "compartment": "compartment_5460", "id": "reaction_10491084", "reactome": "R-DME-8874745", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_1524038" ], "products": [ "species_29374", "species_8874749" ], "modifiers": [ [ "species_10491081", "catalyst" ] ], "additional_components": [ "Q9VL70", "FBgn0040064" ] }, "reaction_10479074": { "compartment": "compartment_5460", "id": "reaction_10479074", "reactome": "R-DME-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_5690531" ], "products": [ "species_159448", "species_159450", "species_5690542" ], "modifiers": [ [ "species_10479071", "catalyst" ] ], "additional_components": [ "FBgn0031703" ] }, "reaction_10487885": { "compartment": "compartment_70101", "id": "reaction_10487885", "reactome": "R-DME-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164991", "species_10487881" ], "products": [ "species_10487883" ], "modifiers": [], "additional_components": [ "FBgn0064116", "Q9VRG6", "FBgn0064116", "species_164991" ] }, "reaction_10479965": { "compartment": "compartment_17951", "id": "reaction_10479965", "reactome": "R-DME-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_6787810" ], "products": [ "species_113575", "species_6787814" ], "modifiers": [ [ "species_10479962", "catalyst" ] ], "additional_components": [ "A1Z8D3", "FBgn0061356" ] }, "reaction_10486915": { "compartment": "compartment_17951", "id": "reaction_10486915", "reactome": "R-DME-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10486912", "catalyst" ] ], "additional_components": [ "FBgn0032790" ] }, "reaction_10487876": { "compartment": "compartment_17947", "id": "reaction_10487876", "reactome": "R-DME-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_10487870" ], "products": [ "species_10487874" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "FBgn0031478", "species_164991", "species_5690542", "Q9VQI6", "FBgn0031478" ] }, "reaction_10446606": { "compartment": "compartment_17951", "id": "reaction_10446606", "reactome": "R-DME-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389982", "species_192307" ], "products": [ "species_193465", "species_389996", "species_192305" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446589": { "compartment": "compartment_17951", "id": "reaction_10446589", "reactome": "R-DME-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10440153", "catalyst" ] ], "additional_components": [ "species_113596", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628" ] }, "reaction_10446637": { "compartment": "compartment_17951", "id": "reaction_10446637", "reactome": "R-DME-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353123", "species_390294" ], "products": [ "species_390287", "species_193514" ], "modifiers": [ [ "species_10446632", "catalyst" ] ], "additional_components": [ "FBgn0038486" ] }, "reaction_10446604": { "compartment": "compartment_17951", "id": "reaction_10446604", "reactome": "R-DME-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_389894" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446635": { "compartment": "compartment_17951", "id": "reaction_10446635", "reactome": "R-DME-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192314", "species_390294" ], "products": [ "species_193514", "species_390274" ], "modifiers": [ [ "species_10446632", "catalyst" ] ], "additional_components": [ "FBgn0038486" ] }, "reaction_10446601": { "compartment": "compartment_17951", "id": "reaction_10446601", "reactome": "R-DME-389897", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389569" ], "products": [ "species_389893" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10446599": { "compartment": "compartment_17951", "id": "reaction_10446599", "reactome": "R-DME-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10446596", "catalyst" ] ], "additional_components": [ "species_113596", "B7Z028", "FBgn0031813" ] }, "reaction_10446627": { "compartment": "compartment_17951", "id": "reaction_10446627", "reactome": "R-DME-390281", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390271", "species_390294" ], "products": [ "species_193514", "species_390290" ], "modifiers": [ [ "species_10446624", "catalyst" ] ], "additional_components": [ "FBgn0039543" ] }, "reaction_10446619": { "compartment": "compartment_17951", "id": "reaction_10446619", "reactome": "R-DME-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10446616", "catalyst" ] ], "additional_components": [ "species_113596", "Q7KML2", "FBgn0027572" ] }, "reaction_10446647": { "compartment": "compartment_17947", "id": "reaction_10446647", "reactome": "R-DME-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10446279", "catalyst" ] ], "additional_components": [ "Q7JUN3", "FBgn0039890" ] }, "reaction_10446610": { "compartment": "compartment_17951", "id": "reaction_10446610", "reactome": "R-DME-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446608": { "compartment": "compartment_17951", "id": "reaction_10446608", "reactome": "R-DME-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446474": { "compartment": "compartment_17951", "id": "reaction_10446474", "reactome": "R-DME-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10446471", "catalyst" ] ], "additional_components": [ "species_8878387", "species_29926", "Q7K3B7", "FBgn0034488" ] }, "reaction_10446488": { "compartment": "compartment_17951", "id": "reaction_10446488", "reactome": "R-DME-389632", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6811612", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389569", "species_389620" ], "modifiers": [ [ "species_10446482", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10446485": { "compartment": "compartment_17951", "id": "reaction_10446485", "reactome": "R-DME-389622", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389596", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389615", "species_389620" ], "modifiers": [ [ "species_10446482", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10446496": { "compartment": "compartment_17947", "id": "reaction_10446496", "reactome": "R-DME-389652", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_389620" ], "products": [ "species_389573", "species_76577" ], "modifiers": [ [ "species_10446493", "catalyst" ] ], "additional_components": [ "FBgn0052250" ] }, "reaction_10484754": { "compartment": "compartment_70101", "id": "reaction_10484754", "reactome": "R-DME-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10484748", "catalyst" ] ], "additional_components": [ "Q9VP65", "FBgn0037061", "Q9VQF8", "FBgn0031454" ] }, "reaction_10479105": { "compartment": "compartment_70101", "id": "reaction_10479105", "reactome": "R-DME-5696230", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5696214" ], "products": [ "species_29356", "species_5696224", "species_111745" ], "modifiers": [ [ "species_10438462", "catalyst" ] ], "additional_components": [ "Q9VSL3", "FBgn0086348" ] }, "reaction_10438713": { "compartment": "compartment_70101", "id": "reaction_10438713", "reactome": "R-DME-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10438710", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438678": { "compartment": "compartment_70101", "id": "reaction_10438678", "reactome": "R-DME-176521", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_158471" ], "products": [ "species_176492", "species_158466" ], "modifiers": [ [ "species_10438632", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438708": { "compartment": "compartment_70101", "id": "reaction_10438708", "reactome": "R-DME-176609", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_158471" ], "products": [ "species_176618", "species_158466" ], "modifiers": [ [ "species_10438667", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438675": { "compartment": "compartment_70101", "id": "reaction_10438675", "reactome": "R-DME-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_158471" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10438672", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438738": { "compartment": "compartment_70101", "id": "reaction_10438738", "reactome": "R-DME-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10438735", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438706": { "compartment": "compartment_70101", "id": "reaction_10438706", "reactome": "R-DME-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_29372", "species_76577" ], "modifiers": [ [ "species_10438703", "catalyst" ] ], "additional_components": [ "FBgn0039698" ] }, "reaction_10435664": { "compartment": "compartment_70101", "id": "reaction_10435664", "reactome": "R-DME-158860", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158847", "species_158471" ], "products": [ "species_158859", "species_158466" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10435662": { "compartment": "compartment_70101", "id": "reaction_10435662", "reactome": "R-DME-158849", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158858", "species_158471" ], "products": [ "species_158466", "species_158850" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438670": { "compartment": "compartment_70101", "id": "reaction_10438670", "reactome": "R-DME-176494", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176617", "species_158471" ], "products": [ "species_176502", "species_158466" ], "modifiers": [ [ "species_10438667", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438733": { "compartment": "compartment_70101", "id": "reaction_10438733", "reactome": "R-DME-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176575", "species_158471" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10438730", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10494994": { "compartment": "compartment_17963", "id": "reaction_10494994", "reactome": "R-DME-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10494991", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_29926", "Q9VYF2", "FBgn0030465" ] }, "reaction_10438698": { "compartment": "compartment_70101", "id": "reaction_10438698", "reactome": "R-DME-176604", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176565", "species_158471" ], "products": [ "species_176483", "species_158466" ], "modifiers": [ [ "species_10438642", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438728": { "compartment": "compartment_70101", "id": "reaction_10438728", "reactome": "R-DME-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695950", "species_158471" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10438725", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438696": { "compartment": "compartment_70101", "id": "reaction_10438696", "reactome": "R-DME-176588", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_158471" ], "products": [ "species_176555", "species_158466" ], "modifiers": [ [ "species_10438642", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438693": { "compartment": "compartment_70101", "id": "reaction_10438693", "reactome": "R-DME-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176667", "species_158471" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10438690", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10435652": { "compartment": "compartment_70101", "id": "reaction_10435652", "reactome": "R-DME-158468", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158469", "species_158471" ], "products": [ "species_158472", "species_158466" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10435745": { "compartment": "compartment_70101", "id": "reaction_10435745", "reactome": "R-DME-159358", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_159362" ], "products": [ "species_159352", "species_158466" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438657": { "compartment": "compartment_70101", "id": "reaction_10438657", "reactome": "R-DME-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10438654", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438525": { "compartment": "compartment_70101", "id": "reaction_10438525", "reactome": "R-DME-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10438522", "catalyst" ] ], "additional_components": [ "CHEBI:29132", "CHEBI:34718", "CHEBI:30614", "CHEBI:8927", "CHEBI:32639", "CHEBI:34479", "A1Z7X7", "FBgn0050005", "Q8MRM0", "FBgn0030484", "Q7K0B6", "FBgn0050000", "E1JJS1", "FBgn0031117", "Q9VSL3", "FBgn0086348", "P41043", "FBgn0010226", "Q9VSL6", "FBgn0035907", "Q9VSL5", "FBgn0035906", "Q9VSL2", "FBgn0035904", "Q9VHD2", "FBgn0037697" ] }, "reaction_10438399": { "compartment": "compartment_70101", "id": "reaction_10438399", "reactome": "R-DME-174367", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111707", "species_113592" ], "products": [ "species_29372", "species_174393", "species_29370" ], "modifiers": [ [ "species_10438396", "catalyst" ] ], "additional_components": [ "Q9VCW6", "FBgn0046114", "Q9W3K5", "FBgn0040319" ] }, "reaction_10458317": { "compartment": "compartment_70101", "id": "reaction_10458317", "reactome": "R-DME-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1247942" ], "products": [ "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10458314", "catalyst" ] ], "additional_components": [ "Q9W247", "FBgn0034733" ] }, "reaction_10493315": { "compartment": "compartment_876", "id": "reaction_10493315", "reactome": "R-DME-8943279", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1247892" ], "products": [ "species_210382", "species_1247934" ], "modifiers": [ [ "species_10472545", "catalyst" ] ], "additional_components": [ "Q7KUX2", "FBgn0030796", "M9NFP5", "FBgn0025837", "Q9VYR2", "FBgn0030361", "Q9VWT3", "FBgn0030932" ] }, "reaction_10458297": { "compartment": "compartment_70101", "id": "reaction_10458297", "reactome": "R-DME-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1247904" ], "products": [ "species_111707", "species_29424" ], "modifiers": [ [ "species_10458294", "catalyst" ] ], "additional_components": [ "species_266099", "Q8MT58", "FBgn0259979" ] }, "reaction_10479737": { "compartment": "compartment_70101", "id": "reaction_10479737", "reactome": "R-DME-6785928", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450" ], "products": [ "species_1247942", "species_1247904" ], "modifiers": [ [ "species_10479732", "catalyst" ] ], "additional_components": [ "FBgn0030411" ] }, "reaction_10458307": { "compartment": "compartment_70101", "id": "reaction_10458307", "reactome": "R-DME-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10458304", "catalyst" ] ], "additional_components": [ "Q8IQT0", "FBgn0052196" ] }, "reaction_10478153": { "compartment": "compartment_17957", "id": "reaction_10478153", "reactome": "R-DME-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10478150", "catalyst" ] ], "additional_components": [ "Q7KSB5", "FBgn0038771" ] }, "reaction_10477976": { "compartment": "compartment_70101", "id": "reaction_10477976", "reactome": "R-DME-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10475407", "catalyst" ] ], "additional_components": [ "FBgn0035476" ] }, "reaction_10438535": { "compartment": "compartment_17957", "id": "reaction_10438535", "reactome": "R-DME-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10438532", "catalyst" ] ], "additional_components": [ "CHEBI:30725", "CHEBI:27561", "CHEBI:29132", "CHEBI:32639", "CHEBI:2505", "CHEBI:35896", "Q8SY19", "FBgn0025814" ] }, "reaction_10478143": { "compartment": "compartment_17957", "id": "reaction_10478143", "reactome": "R-DME-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10478140", "catalyst" ] ], "additional_components": [ "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943", "A1ZA97", "FBgn0034076" ] }, "reaction_10479631": { "compartment": "compartment_70101", "id": "reaction_10479631", "reactome": "R-DME-6784959", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6784964" ], "products": [ "species_29702", "species_561052" ], "modifiers": [ [ "species_10479628", "catalyst" ] ], "additional_components": [ "FBgn0038974" ] }, "reaction_10478233": { "compartment": "compartment_12045", "id": "reaction_10478233", "reactome": "R-DME-5694077", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694080" ], "products": [ "species_5694091" ], "modifiers": [ [ "species_10478230", "catalyst" ] ], "additional_components": [ "FBgn0034405" ] }, "reaction_10429084": { "compartment": "compartment_70101", "id": "reaction_10429084", "reactome": "R-DME-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10429081", "catalyst" ] ], "additional_components": [ "P46415", "FBgn0011768", "species_1562550" ] }, "reaction_10429112": { "compartment": "compartment_70101", "id": "reaction_10429112", "reactome": "R-DME-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29416", "species_76194" ], "products": [ "species_111294", "species_76183", "species_76577" ], "modifiers": [ [ "species_10429109", "catalyst" ] ], "additional_components": [ "FBgn0012034" ] }, "reaction_10429094": { "compartment": "compartment_5460", "id": "reaction_10429094", "reactome": "R-DME-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10429091", "catalyst" ] ], "additional_components": [ "Q9VLC5", "FBgn0012036" ] }, "reaction_10479094": { "compartment": "compartment_5460", "id": "reaction_10479094", "reactome": "R-DME-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10429091", "catalyst" ] ], "additional_components": [ "Q9VLC5", "FBgn0012036" ] }, "reaction_10477985": { "compartment": "compartment_70101", "id": "reaction_10477985", "reactome": "R-DME-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10477982", "catalyst" ] ], "additional_components": [ "species_1562550", "P46415", "FBgn0011768" ] }, "reaction_10492075": { "compartment": "compartment_70101", "id": "reaction_10492075", "reactome": "R-DME-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_8936443", "species_73473" ], "products": [ "species_29356", "species_29468", "species_29360" ], "modifiers": [ [ "species_10492072", "catalyst" ] ], "additional_components": [ "A1Z803", "FBgn0033451", "CHEBI:21437", "X2JGK6", "FBgn0036211", "Q9V4N3", "FBgn0264294" ] }, "reaction_10492235": { "compartment": "compartment_70101", "id": "reaction_10492235", "reactome": "R-DME-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10492232", "catalyst" ] ], "additional_components": [ "P23654", "FBgn0004108", "Q8T016", "FBgn0033943", "Q9VLA3", "FBgn0032132", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076" ] }, "reaction_10465054": { "compartment": "compartment_70101", "id": "reaction_10465054", "reactome": "R-DME-2161500", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161525" ], "products": [ "species_2161185" ], "modifiers": [ [ "species_10465051", "catalyst" ] ], "additional_components": [ "Q7K3M6", "FBgn0034479", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10455658": { "compartment": "compartment_876", "id": "reaction_10455658", "reactome": "R-DME-975340", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10455655", "catalyst" ] ], "additional_components": [ "species_352011", "Q8SWZ1", "FBgn0033558", "Q08832", "FBgn0010240", "P25123", "FBgn0004244", "Q9VXL9", "FBgn0030707", "Q24352", "FBgn0001134", "Q9W0S2", "FBgn0264707" ] }, "reaction_10455765": { "compartment": "compartment_876", "id": "reaction_10455765", "reactome": "R-DME-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10455762", "catalyst" ] ], "additional_components": [ "species_352011", "Q8SWZ1", "FBgn0033558", "Q08832", "FBgn0010240", "P25123", "FBgn0004244" ] }, "reaction_10435001": { "compartment": "compartment_70101", "id": "reaction_10435001", "reactome": "R-DME-114683", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434995", "species_113592" ], "products": [ "species_29370", "species_10434998" ], "modifiers": [ [ "species_10434975", "catalyst" ] ], "additional_components": [ "FBgn0004574", "FBgn0004574", "species_114519", "species_33625", "species_74016", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10452783": { "compartment": "compartment_876", "id": "reaction_10452783", "reactome": "R-DME-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452699" ], "products": [ "species_10452781" ], "modifiers": [], "additional_components": [ "species_29438", "Q9VH14", "FBgn0025879", "species_29370", "species_29926", "Q9VN93", "FBgn0260462", "Q9VKY4", "FBgn0032228", "species_113592", "species_29372", "Q24276", "FBgn0011573", "species_74016", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q7K187", "FBgn0030330", "species_114523", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "species_29420", "species_113541", "species_74016", "species_29438", "Q9VH14", "FBgn0025879", "species_29370", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "species_113541", "species_29926", "species_113592", "Q7K187", "FBgn0030330", "Q9VN93", "FBgn0260462", "Q9VKY4", "FBgn0032228", "species_114523", "species_29372", "Q24276", "FBgn0011573", "species_29420", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10452814": { "compartment": "compartment_876", "id": "reaction_10452814", "reactome": "R-DME-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452802" ], "products": [ "species_10452812" ], "modifiers": [], "additional_components": [ "B7YZX0", "FBgn0032797", "Q9VLH1", "FBgn0032074", "Q9V9S0", "FBgn0032949", "O76901", "FBgn0025382", "O76901", "FBgn0025382", "B7YZX0", "FBgn0032797", "Q9VLH1", "FBgn0032074", "Q9V9S0", "FBgn0032949" ] }, "reaction_10444110": { "compartment": "compartment_161320", "id": "reaction_10444110", "reactome": "R-DME-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444102" ], "products": [ "species_10444108" ], "modifiers": [], "additional_components": [ "Q9Y125", "FBgn0000416", "Q9VLS0", "FBgn0031996", "Q9Y125", "FBgn0000416", "Q9VLS0", "FBgn0031996" ] }, "reaction_10452605": { "compartment": "compartment_876", "id": "reaction_10452605", "reactome": "R-DME-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452245" ], "products": [ "species_10452603" ], "modifiers": [], "additional_components": [ "Q7JQR3", "FBgn0033814", "Q9VLU2", "FBgn0031975", "Q9VK28", "FBgn0032479", "Q8SXT3", "FBgn0034262", "Q9VK22", "FBgn0032484", "Q9VKG1", "FBgn0015400", "D0IQL1", "FBgn0034540", "Q9VJN8", "FBgn0028518", "Q9VK54", "FBgn0015399", "A0A4D6K327", "FBgn0261509", "Q9V430", "FBgn0028370", "O97365", "FBgn0026562", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "O77277", "FBgn0025615", "Q9VX97", "FBgn0030803", "A1Z9D7", "FBgn0000119", "P18091", "FBgn0000667", "Q9VWP6", "FBgn0030964", "Q9I7L4", "FBgn0037481", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q7K1H0", "FBgn0052066", "Q8SWU7", "FBgn0030151", "P14599", "FBgn0000108", "Q960F7", "FBgn0037391", "Q9VU94", "FBgn0029167", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P07713", "FBgn0000490", "Q9VN86", "FBgn0037298", "Q9W5T4", "FBgn0250830", "Q9VM97", "FBgn0031850", "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688", "Q9W0A0", "FBgn0027594", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9VEY5", "FBgn0038400", "Q9VH14", "FBgn0025879", "D0IQL1", "FBgn0034540", "A0A4D6K327", "FBgn0261509", "Q9VKG1", "FBgn0015400", "Q9VK54", "FBgn0015399", "Q9VK28", "FBgn0032479", "Q9VK22", "FBgn0032484", "Q9VJN8", "FBgn0028518", "Q9V430", "FBgn0028370", "Q8SXT3", "FBgn0034262", "Q7JQR3", "FBgn0033814", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "O97365", "FBgn0026562", "P07713", "FBgn0000490", "Q9W0A0", "FBgn0027594", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9VH14", "FBgn0025879", "Q9VLU2", "FBgn0031975", "P18091", "FBgn0000667", "Q9VM97", "FBgn0031850", "A1Z9D7", "FBgn0000119", "Q9VN86", "FBgn0037298", "Q9VWP6", "FBgn0030964", "Q9W5T4", "FBgn0250830", "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VX97", "FBgn0030803", "O77277", "FBgn0025615", "Q9VU94", "FBgn0029167", "P14599", "FBgn0000108", "Q9I7L4", "FBgn0037481", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q7K1H0", "FBgn0052066", "Q8SWU7", "FBgn0030151", "Q960F7", "FBgn0037391", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q9VEY5", "FBgn0038400" ] }, "reaction_10453019": { "compartment": "compartment_70101", "id": "reaction_10453019", "reactome": "R-DME-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452947" ], "products": [ "species_10453017" ], "modifiers": [], "additional_components": [ "Q07327", "FBgn0004574", "Q7JVP4", "FBgn0033155", "P61851", "FBgn0003462", "Q9VSL8", "FBgn0260442", "Q9VU68", "FBgn0260049", "Q9XZ63", "FBgn0027095", "O46037", "FBgn0004397", "Q9VZI1", "FBgn0035499", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "Q9VEN1", "FBgn0014141", "Q9V426", "FBgn0024183", "D2A6L8", "FBgn0265047", "Q9VED6", "FBgn0038565", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q7JVP4", "FBgn0033155", "P61851", "FBgn0003462", "Q9XZ63", "FBgn0027095", "Q9VED6", "FBgn0038565", "Q9VU68", "FBgn0260049", "Q9VZI1", "FBgn0035499", "O46037", "FBgn0004397", "Q07327", "FBgn0004574", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q9VSL8", "FBgn0260442", "Q9VEN1", "FBgn0014141", "Q9V426", "FBgn0024183", "D2A6L8", "FBgn0265047", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743" ] }, "reaction_10452903": { "compartment": "compartment_984", "id": "reaction_10452903", "reactome": "R-DME-482770", "name": "Release of platelet secretory granule components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452899" ], "products": [ "species_10452901" ], "modifiers": [], "additional_components": [ "FBgn0022355", "FBgn0022355" ] }, "reaction_10452882": { "compartment": "compartment_876", "id": "reaction_10452882", "reactome": "R-DME-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452858" ], "products": [ "species_10452880" ], "modifiers": [], "additional_components": [ "Q961B9", "FBgn0036579", "Q9VZN0", "FBgn0052264", "P14599", "FBgn0000108", "Q9W0X9", "FBgn0035085", "B7YZX0", "FBgn0032797", "Q9VID1", "FBgn0032943", "Q9VFH5", "FBgn0038247", "Q9VGG5", "FBgn0037963", "Q9NFV7", "FBgn0041182", "X2JGK6", "FBgn0036211", "E1JI63", "FBgn0035815", "P14599", "FBgn0000108", "Q9W0X9", "FBgn0035085", "Q9VID1", "FBgn0032943", "Q9NFV7", "FBgn0041182", "E1JI63", "FBgn0035815", "X2JGK6", "FBgn0036211", "B7YZX0", "FBgn0032797", "Q961B9", "FBgn0036579", "Q9VZN0", "FBgn0052264", "Q9VGG5", "FBgn0037963", "Q9VFH5", "FBgn0038247" ] }, "reaction_10448864": { "compartment": "compartment_114584", "id": "reaction_10448864", "reactome": "R-DME-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_114565" ], "modifiers": [ [ "species_10448861", "catalyst" ] ], "additional_components": [ "FBgn0032026" ] }, "reaction_10434977": { "compartment": "compartment_70101", "id": "reaction_10434977", "reactome": "R-DME-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_74016", "species_10434959" ], "products": [ "species_10434975" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "P13677", "FBgn0004784", "P05130", "FBgn0003091", "species_114519", "species_33625", "species_74016", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10457707": { "compartment": "compartment_70101", "id": "reaction_10457707", "reactome": "R-DME-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457703" ], "products": [ "species_10457705" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10443664": { "compartment": "compartment_984", "id": "reaction_10443664", "reactome": "R-DME-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10443660" ], "products": [ "species_10443662" ], "modifiers": [], "additional_components": [ "Q9VRC9", "FBgn0261675", "Q9VL24", "FBgn0024320", "Q9VRC9", "FBgn0261675", "Q9VL24", "FBgn0024320", "species_265479" ] }, "reaction_10439533": { "compartment": "compartment_876", "id": "reaction_10439533", "reactome": "R-DME-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10439530", "catalyst" ] ], "additional_components": [ "FBgn0264574" ] }, "reaction_10439540": { "compartment": "compartment_876", "id": "reaction_10439540", "reactome": "R-DME-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10439537", "catalyst" ] ], "additional_components": [ "species_964746", "species_188995", "species_29532", "species_188995", "species_964746", "species_29532", "Q8IRI6", "FBgn0264574" ] }, "reaction_209376": { "compartment": "compartment_984", "id": "reaction_209376", "reactome": "R-DME-209376", "name": "SPN27A binds to and inhibits EA protease activity", "reversible": "false", "notes": "In dorsoventral patterning, the serpin SPN27A binds to Easter (EA) serine protease. This complex inhibits Spatzle (SPZ) dimer processing.", "reactants": [ "species_205912", "species_206231" ], "products": [ "species_206652" ], "modifiers": [], "additional_components": [ "Q9V3N1", "Spn27A", "P13582", "ProEA" ] }, "reaction_209141": { "compartment": "compartment_984", "id": "reaction_209141", "reactome": "R-DME-209141", "name": "ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane", "reversible": "false", "notes": "On binding to the Toll (TL) receptor ectodomain, Spatzle (SPZ) dimer sheds its Pro-domains. The SPZ dimer binds to the TL ectodomain at its N-terminus.", "reactants": [ "species_206793", "species_206218" ], "products": [ "species_205949", "species_206655" ], "modifiers": [], "additional_components": [ "P48607", "ProSPZ", "P08953", "TL", "P48607", "ProSPZ" ] }, "reaction_209076": { "compartment": "compartment_876", "id": "reaction_209076", "reactome": "R-DME-209076", "name": "SPZ dimer bound TL dimerises at the plasma membrane", "reversible": "false", "notes": "The binding of a Spatzle (SPZ) dimer to the N-terminus of the Toll (TL) receptor ectodomain triggers a conformational change in TL. This results in two discrete regions of the TL receptor ectodomains, one near the N-terminus and the other in the juxtamembrane region, to interact, inducing dimerisation and forming a 2:2 complex. The transmembrane segments of the receptor chains will be forced into close proximity forming additional favourable interactions which stabilise the dimer.", "reactants": [ "species_206655" ], "products": [ "species_206637" ], "modifiers": [], "additional_components": [ "P08953", "TL", "P48607", "ProSPZ", "P08953", "TL", "P48607", "ProSPZ" ] }, "reaction_209156": { "compartment": "compartment_70101", "id": "reaction_209156", "reactome": "R-DME-209156", "name": "MYD88 binds to TUB", "reversible": "false", "notes": "In close proximity to the plasma membrane, the adaptor proteins MYD88 and Tube (TUB) bind together through their death domains.", "reactants": [ "species_206015", "species_206155" ], "products": [ "species_206621" ], "modifiers": [], "additional_components": [ "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214891": { "compartment": "compartment_984", "id": "reaction_214891", "reactome": "R-DME-214891", "name": "Full-length GD is cleaved by an unknown protease", "reversible": "false", "notes": "During early embryonic patterning, Toll (TL) is required for establishing the dorsoventral axis. The TL signal is initiated by activation of its ligand Spatzle (SPZ) by a serine protease cascade. Activation of this cascade is regulated by the probable chaperone protein Windbeutel (WBL) and by Pipe (PIP), a heparan-sulphanotransferase that has been proposed to create a heparin-modified proteoglycan that is required for local activation of the cascade. PIP is the only dorsoventral factor to be expressed on the ventral side of the embryo and is thought to be the key in activating the cascade. The full-length serine protease zymogen, Gastrulation Defective (GD) is cleaved between Arg136 and Lys137. This separates the inhibitory prodomain from the now active mature enzyme. How GD is activated remains uncertain, although a direct interaction with Nudel (NDL) or autoproteolytic processing cannot be ruled out.", "reactants": [ "species_214753" ], "products": [ "species_214276", "species_214754" ], "modifiers": [ [ "species_214274", "catalyst" ] ], "additional_components": [] }, "reaction_209130": { "compartment": "compartment_984", "id": "reaction_209130", "reactome": "R-DME-209130", "name": "Full-length SPZ dimer is cleaved by EA/SPE serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the trypsin-like serine protease Easter (EA) is known to cleave full-length Spatzle (SPZ) dimer between residues Arg220 and Val221. This frees the Pro-domain and the C-terminal SPZ dimer aka C-106. In the innate immunity response, the serine protease cleavage enzyme is the Spatzle-processing enzyme aka SPE (CG16705). The Pro-domains and the SPZ dimer remain associated after cleavage.", "reactants": [ "species_206598" ], "products": [ "species_206793" ], "modifiers": [ [ "species_206576", "catalyst" ] ], "additional_components": [ "P48607", "ProSPZ", "P48607", "ProSPZ", "Q9VCJ8", "SPE", "P13582", "ProEA" ] }, "reaction_214953": { "compartment": "compartment_984", "id": "reaction_214953", "reactome": "R-DME-214953", "name": "Full-length SNK is cleaved by GD serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the full-length serine protease zymogen, Snake (SNK), is cleaved by active Gastrulation Defective (GD) serine protease between residues Leu185 and Ile186. The removal of the prodomain results in an active SNK protease.", "reactants": [ "species_214747" ], "products": [ "species_214750", "species_214280" ], "modifiers": [ [ "species_214276", "catalyst" ] ], "additional_components": [] }, "reaction_214853": { "compartment": "compartment_70101", "id": "reaction_214853", "reactome": "R-DME-214853", "name": "WEK and MYD88:TUB bind to the TL receptor", "reversible": "false", "notes": "Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homodimerisation and activation. In dorsoventral patterning in Drosophila embryos, the zinc finger containing adaptor protein Weckle, (WEK) binds to both the TL receptor cytoplasmic domain and the adaptor protein MYD88, which in complex with Tube (TUB), also binds to TL. In addition, WEK forms dimers through its N-terminal region.", "reactants": [ "species_206621", "species_206637", "species_214745" ], "products": [ "species_214743" ], "modifiers": [], "additional_components": [ "P22812", "TUB", "Q7K105", "MYD88", "P08953", "TL", "P48607", "ProSPZ", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_209100": { "compartment": "compartment_70101", "id": "reaction_209100", "reactome": "R-DME-209100", "name": "MYD88:TUB binds to TL receptor", "reversible": "false", "notes": "Upon Spatzle (SPZ) dimer binding, leading to Toll (TL) receptor homodimerisation and activation, MYD88:TUB complex binds to the endoplasmic Toll/Interleukin-1 receptor (TIR) domain of TL receptor at the plasma membrane.", "reactants": [ "species_206621", "species_206637" ], "products": [ "species_206600" ], "modifiers": [], "additional_components": [ "P22812", "TUB", "Q7K105", "MYD88", "P08953", "TL", "P48607", "ProSPZ", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214956": { "compartment": "compartment_984", "id": "reaction_214956", "reactome": "R-DME-214956", "name": "Full-length EA is cleaved by SNK serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the full-length serine protease zymogen, Easter (EA) is cleaved by active serine protease, Snake (SNK), between residues Arg127 and Ile128. The removal of the inhibitory prodomain results in an active EA serine protease.", "reactants": [ "species_214751" ], "products": [ "species_205912", "species_214755" ], "modifiers": [ [ "species_214280", "catalyst" ] ], "additional_components": [] }, "reaction_214871": { "compartment": "compartment_70101", "id": "reaction_214871", "reactome": "R-DME-214871", "name": "Phosphorylated CACT is degraded in the cytosol", "reversible": "false", "notes": "In humans, the Cactus (CACT) orthologue IkappaB is polyubiquitinated by the beta-TrCP E3 ubiquitin ligase containing complex. This marks it for degradation by the 26S proteosome. It is believed that CACT is degraded in a similar manner, however, a Drosophila E3 ubiquitin ligase that acts in the Toll pathway has yet to be identified. The obvious candidate, the closest beta-TrCP orthologue Slimb (SLMB) has produced contradictory evidence on whether it participates in the Toll pathway (Spencer et al., 1999; Leulier et al., 2003).", "reactants": [ "species_214741" ], "products": [ "species_214728" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P15330", "dl", "P98149", "Dif", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_214864": { "compartment": "compartment_70101", "id": "reaction_214864", "reactome": "R-DME-214864", "name": "Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Once phosphorylated, Cactus (CACT), in complex with the Dorsal/Dorsal-related immunity factor (DL/DIF) homodimer, dissociates from the Toll (TL) receptor 'signalling complex'.", "reactants": [ "species_214748" ], "products": [ "species_214741", "species_206693" ], "modifiers": [], "additional_components": [ "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL" ] }, "reaction_214847": { "compartment": "compartment_70101", "id": "reaction_214847", "reactome": "R-DME-214847", "name": "Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Once phosphorylated, Cactus (CACT), in complex with the Dorsal (DL) homodimer, dissociates from the Toll (TL) receptor 'signalling complex'.", "reactants": [ "species_214749" ], "products": [ "species_214759", "species_214752" ], "modifiers": [], "additional_components": [ "P15330", "dl", "Q03017", "phospho-cact", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "P15330", "dl", "Q03017", "phospho-cact" ] }, "reaction_209057": { "compartment": "compartment_70101", "id": "reaction_209057", "reactome": "R-DME-209057", "name": "Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "On binding to the 'signalling complex', the Ser/Thr kinase Pelle (PLL) is activated and autophosphorylates.", "reactants": [ "species_206889", "species_113592" ], "products": [ "species_29370", "species_206693" ], "modifiers": [ [ "species_206889", "catalyst" ] ], "additional_components": [ "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214859": { "compartment": "compartment_70101", "id": "reaction_214859", "reactome": "R-DME-214859", "name": "Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "On binding to the 'signalling complex', the Ser/Thr kinase Pelle (PLL) is activated and autophosphorylates.", "reactants": [ "species_113592", "species_214742" ], "products": [ "species_29370", "species_214759" ], "modifiers": [ [ "species_214742", "catalyst" ] ], "additional_components": [ "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214845": { "compartment": "compartment_70101", "id": "reaction_214845", "reactome": "R-DME-214845", "name": "CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Pelle (PLL) may be the kinase that phosphorylates both Cactus (CACT) and the Dorsal (DL) homodimer but the biochemical evidence for this is currently inconclusive. CACT is phosphorylated in its N-terminal half within the first 125 residues. In this region, there are two IKK target-like motifs, involving Ser74 and Ser78 in one, and Ser116 in the other. However, it is not clear which of these residues need to be phosphorylated. DL homodimer is phosphorylated at both Ser317 residues while associated with CACT.", "reactants": [ "species_113592", "species_214758" ], "products": [ "species_214749", "species_29370" ], "modifiers": [ [ "species_206306", "catalyst" ] ], "additional_components": [ "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P15330", "dl", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "P15330", "dl", "Q03017", "phospho-cact", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214860": { "compartment": "compartment_70101", "id": "reaction_214860", "reactome": "R-DME-214860", "name": "CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Pelle (PLL) may be the kinase that phosphorylates both Cactus (CACT) and the Dorsal/Dorsal-related immunity factor (DL/DIF) homodimer but the biochemical evidence for this is currently inconclusive. DL/DIF homodimer is phosphorylated while associated with CACT. DL is phosphorylated on Ser317 while DIF is very likely to be phosphorylated at Ser348 (inferred from DL). CACT is phosphorylated in its N-terminal half within the first 125 residues. In this region, there are two IKK target-like motifs, involving Ser74 and Ser78 in one, and Ser116 in the other. However, it is not clear which of these residues need to be phosphorylated.", "reactants": [ "species_214744", "species_113592" ], "products": [ "species_214748", "species_29370" ], "modifiers": [ [ "species_206306", "catalyst" ] ], "additional_components": [ "P08953", "TL", "P48607", "ProSPZ", "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL" ] }, "reaction_10466911": { "compartment": "compartment_876", "id": "reaction_10466911", "reactome": "R-DME-2730862", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466905" ], "products": [ "species_29370", "species_10466908" ], "modifiers": [ [ "species_10466905", "catalyst" ] ], "additional_components": [ "FBgn0262733", "FBgn0262733", "FBgn0262733" ] }, "reaction_10441884": { "compartment": "compartment_70101", "id": "reaction_10441884", "reactome": "R-DME-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441880", "species_202277" ], "products": [ "species_10441882" ], "modifiers": [], "additional_components": [ "species_202247", "species_179838", "species_202247", "species_179838", "Q9W0V1", "Pdk1" ] }, "reaction_10466859": { "compartment": "compartment_876", "id": "reaction_10466859", "reactome": "R-DME-2730842", "name": "PI3K associates with phosphorylated GAB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466855", "species_10431820" ], "products": [ "species_10466857" ], "modifiers": [], "additional_components": [ "Q9VZZ9", "FBgn0016794", "species_179838", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VZZ9", "FBgn0016794", "species_179838", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466946": { "compartment": "compartment_876", "id": "reaction_10466946", "reactome": "R-DME-2730870", "name": "Phosphorylation of PIP2 to PIP3 by PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10466857", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VZZ9", "FBgn0016794", "species_179838", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466861": { "compartment": "compartment_70101", "id": "reaction_10466861", "reactome": "R-DME-2730844", "name": "Interaction of GRB2:SOS complex with p-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10465768" ], "products": [ "species_10465770" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466844": { "compartment": "compartment_876", "id": "reaction_10466844", "reactome": "R-DME-2730841", "name": "Phosphorylation and activation of VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466842" ], "products": [ "species_10466835", "species_29370" ], "modifiers": [ [ "species_179838", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466840": { "compartment": "compartment_70101", "id": "reaction_10466840", "reactome": "R-DME-2730840", "name": "Activation of RAC1 by VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10466835", "species_428485" ], "products": [ "species_29420", "species_10466837" ], "modifiers": [ [ "species_10466835", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "P40792", "RAC1_DROME", "species_29420", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466952": { "compartment": "compartment_876", "id": "reaction_10466952", "reactome": "R-DME-2730889", "name": "Recruitment of PAK to the membrane by binding active RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466884", "species_10466837" ], "products": [ "species_10466886" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10466903": { "compartment": "compartment_876", "id": "reaction_10466903", "reactome": "R-DME-2730858", "name": "Autophosphorylation of BTK/ITK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466826" ], "products": [ "species_10466900", "species_29370" ], "modifiers": [ [ "species_10466826", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "species_179838", "P08630", "FBgn0003502", "P08630", "FBgn0003502", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "species_179838", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "species_179838", "P08630", "FBgn0003502" ] }, "reaction_10466871": { "compartment": "compartment_70101", "id": "reaction_10466871", "reactome": "R-DME-2730847", "name": "Hydrolysis of PIP2 by PLCG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10466868", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "species_179838", "P08630", "FBgn0003502", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VXH3", "FBgn0003416" ] }, "reaction_10477775": { "compartment": "compartment_70101", "id": "reaction_10477775", "reactome": "R-DME-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477766" ], "products": [ "species_10477770", "species_10477772" ], "modifiers": [ [ "species_10477766", "catalyst" ] ], "additional_components": [ "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725", "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725", "FBgn0032725", "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725" ] }, "reaction_10475484": { "compartment": "compartment_70101", "id": "reaction_10475484", "reactome": "R-DME-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475473", "species_10475480" ], "products": [ "species_10475482" ], "modifiers": [], "additional_components": [ "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q9XZ61", "Uch-L5" ] }, "reaction_10477752": { "compartment": "compartment_7660", "id": "reaction_10477752", "reactome": "R-DME-5690785", "name": "BAP1 binds Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477180", "species_10477741" ], "products": [ "species_10477743" ], "modifiers": [], "additional_components": [ "FBgn0262166", "FBgn0039904", "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166" ] }, "reaction_10477720": { "compartment": "compartment_70101", "id": "reaction_10477720", "reactome": "R-DME-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477715" ], "products": [ "species_1131871", "species_10477717" ], "modifiers": [ [ "species_10477715", "catalyst" ] ], "additional_components": [ "P35122", "FBgn0010288", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P35122", "FBgn0010288", "P35122", "FBgn0010288", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10477175": { "compartment": "compartment_7660", "id": "reaction_10477175", "reactome": "R-DME-5689544", "name": "UCHL5 binds INO80 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477169", "species_10477171" ], "products": [ "species_10477173" ], "modifiers": [], "additional_components": [ "Q7K012", "FBgn0025716", "Q9Y0Z1", "FBgn0027503", "Q8ST83", "FBgn0002521", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "Q9W3D4", "FBgn0040929", "Q9VH07", "FBgn0040078", "A1Z6E8", "FBgn0033019", "A1Z8D5", "FBgn0033566", "Q9VX09", "FBgn0030877", "Q9VFH4", "FBgn0086686", "Q9VEC3", "FBgn0038576", "Q4V604", "FBgn0052202", "Q9VDY1", "FBgn0086613", "Q9VZJ3", "FBgn0263832", "Q9XZ61", "Uch-L5", "Q7K012", "FBgn0025716", "Q9Y0Z1", "FBgn0027503", "Q8ST83", "FBgn0002521", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "Q9W3D4", "FBgn0040929", "Q9VH07", "FBgn0040078", "A1Z6E8", "FBgn0033019", "A1Z8D5", "FBgn0033566", "Q9VX09", "FBgn0030877", "Q9VFH4", "FBgn0086686", "Q9VEC3", "FBgn0038576", "Q4V604", "FBgn0052202", "Q9VDY1", "FBgn0086613", "Q9VZJ3", "FBgn0263832" ] }, "reaction_10477750": { "compartment": "compartment_7660", "id": "reaction_10477750", "reactome": "R-DME-5690759", "name": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477743" ], "products": [ "species_10477745", "species_10477747" ], "modifiers": [ [ "species_10477743", "catalyst" ] ], "additional_components": [ "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166", "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166" ] }, "reaction_10475507": { "compartment": "compartment_70101", "id": "reaction_10475507", "reactome": "R-DME-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427203", "species_10475478" ], "products": [ "species_10475480" ], "modifiers": [], "additional_components": [ "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "FBgn0033886", "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10477216": { "compartment": "compartment_7660", "id": "reaction_10477216", "reactome": "R-DME-5689630", "name": "BAP1 binds BAP1-interacting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477212", "species_10477180" ], "products": [ "species_10477214" ], "modifiers": [], "additional_components": [ "Q8ST83", "FBgn0002521", "Q9V4C8", "FBgn0039904", "Q7KJA9", "FBgn0261403", "M9PF47", "FBgn0036134", "Q9W3Q5", "FBgn0029504", "Q9V727", "FBgn0261823", "FBgn0262166", "Q7K5N4", "FBgn0262166", "Q8ST83", "FBgn0002521", "Q9V4C8", "FBgn0039904", "Q7KJA9", "FBgn0261403", "M9PF47", "FBgn0036134", "Q9W3Q5", "FBgn0029504", "Q9V727", "FBgn0261823" ] }, "reaction_10455103": { "compartment": "compartment_984", "id": "reaction_10455103", "reactome": "R-DME-917888", "name": "apoTF binds 2Fe3+ to form holoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452901", "species_912516" ], "products": [ "species_10455101" ], "modifiers": [], "additional_components": [ "FBgn0022355", "species_1222611", "Q9VWV6", "FBgn0022355" ] }, "reaction_10477961": { "compartment": "compartment_70101", "id": "reaction_10477961", "reactome": "R-DME-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477840", "species_10426987" ], "products": [ "species_10477952" ], "modifiers": [ [ "species_10477958", "catalyst" ] ], "additional_components": [ "Q9VGZ3", "FBgn0024957", "Q9VCV4", "FBgn0024958", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGZ3", "FBgn0024957", "Q9VCV4", "FBgn0024958", "Q9VJ33", "FBgn0032725", "Q24311", "Cul1", "O77430", "SkpA" ] }, "reaction_10477944": { "compartment": "compartment_5460", "id": "reaction_10477944", "reactome": "R-DME-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10477941", "catalyst" ] ], "additional_components": [ "Q9VYH1", "FBgn0030449" ] }, "reaction_10477831": { "compartment": "compartment_70101", "id": "reaction_10477831", "reactome": "R-DME-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477827", "species_5690881" ], "products": [ "species_10477829" ], "modifiers": [], "additional_components": [ "FBgn0024957", "Q9VGZ3", "FBgn0024957" ] }, "reaction_10477845": { "compartment": "compartment_70101", "id": "reaction_10477845", "reactome": "R-DME-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10477829", "catalyst" ] ], "additional_components": [ "Q9VGZ3", "FBgn0024957" ] }, "reaction_10455096": { "compartment": "compartment_74700", "id": "reaction_10455096", "reactome": "R-DME-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_70106", "species_113592" ], "products": [ "species_29372", "species_29370", "species_74722" ], "modifiers": [ [ "species_10431765", "catalyst" ] ], "additional_components": [ "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q7JR49", "FBgn0262515" ] }, "reaction_10455111": { "compartment": "compartment_74700", "id": "reaction_10455111", "reactome": "R-DME-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10455108", "catalyst" ] ], "additional_components": [ "FBgn0261361" ] }, "reaction_10459940": { "compartment": "compartment_70101", "id": "reaction_10459940", "reactome": "R-DME-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71067", "species_29368" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10449619", "catalyst" ] ], "additional_components": [ "Q9VYH1", "FBgn0030449" ] }, "reaction_10477970": { "compartment": "compartment_70101", "id": "reaction_10477970", "reactome": "R-DME-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438329", "species_10477966" ], "products": [ "species_10477968" ], "modifiers": [], "additional_components": [ "FBgn0027568", "Q9VKY2", "FBgn0027568", "Q24311", "Cul1" ] }, "reaction_10493560": { "compartment": "compartment_70616", "id": "reaction_10493560", "reactome": "R-DME-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10493557", "catalyst" ] ], "additional_components": [ "Q7JX57", "FBgn0062440", "Q8IQ70", "FBgn0042185", "A2VEI2", "FBgn0031893" ] }, "reaction_10493619": { "compartment": "compartment_70616", "id": "reaction_10493619", "reactome": "R-DME-8949649", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493605" ], "products": [ "species_10493607", "species_10493553", "species_10493601" ], "modifiers": [ [ "species_10493616", "catalyst" ] ], "additional_components": [ "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q7JX57", "FBgn0062440", "FBgn0062440", "FBgn0062440", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q7K3W2", "FBgn0033235", "Q9VFF0", "FBgn0038271" ] }, "reaction_10493622": { "compartment": "compartment_70616", "id": "reaction_10493622", "reactome": "R-DME-8949659", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493553" ], "products": [], "modifiers": [ [ "species_10493601", "catalyst" ] ], "additional_components": [ "FBgn0062440", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551" ] }, "reaction_10493624": { "compartment": "compartment_70616", "id": "reaction_10493624", "reactome": "R-DME-8949661", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493603", "species_10493601" ], "products": [ "species_10493605" ], "modifiers": [], "additional_components": [ "FBgn0062440", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q7JX57", "FBgn0062440" ] }, "reaction_10493629": { "compartment": "compartment_70616", "id": "reaction_10493629", "reactome": "R-DME-8949688", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2889072", "species_8949220" ], "products": [ "species_8949232", "species_2889083" ], "modifiers": [ [ "species_10493626", "catalyst" ] ], "additional_components": [ "FBgn0033324" ] }, "reaction_10471663": { "compartment": "compartment_70101", "id": "reaction_10471663", "reactome": "R-DME-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10471660", "catalyst" ] ], "additional_components": [ "FBgn0032015" ] }, "reaction_10471086": { "compartment": "compartment_70101", "id": "reaction_10471086", "reactome": "R-DME-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471077", "species_10471082" ], "products": [ "species_10471084" ], "modifiers": [], "additional_components": [ "Q02645", "FBgn0263391", "FBgn0051352", "E1JIH3", "FBgn0051352", "Q02645", "FBgn0263391" ] }, "reaction_10471094": { "compartment": "compartment_70101", "id": "reaction_10471094", "reactome": "R-DME-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471090", "species_10471082" ], "products": [ "species_10471092" ], "modifiers": [], "additional_components": [ "Q02645", "FBgn0263391", "FBgn0051352", "E1JIH3", "FBgn0051352", "Q02645", "FBgn0263391" ] }, "reaction_10471636": { "compartment": "compartment_70101", "id": "reaction_10471636", "reactome": "R-DME-5336453", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10471627", "catalyst" ] ], "additional_components": [ "FBgn0032451" ] }, "reaction_10471650": { "compartment": "compartment_70101", "id": "reaction_10471650", "reactome": "R-DME-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10471647", "catalyst" ] ], "additional_components": [ "FBgn0032015" ] }, "reaction_10493197": { "compartment": "compartment_70101", "id": "reaction_10493197", "reactome": "R-DME-8941543", "name": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941540" ], "products": [ "species_8941541" ], "modifiers": [ [ "species_10493194", "catalyst" ] ], "additional_components": [ "species_352022", "species_209818", "species_209818", "species_352022", "Q0E8W8", "FBgn0035008" ] }, "reaction_10453114": { "compartment": "compartment_876", "id": "reaction_10453114", "reactome": "R-DME-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10453109", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884" ] }, "reaction_10453112": { "compartment": "compartment_876", "id": "reaction_10453112", "reactome": "R-DME-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10453109", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884" ] }, "reaction_10479551": { "compartment": "compartment_1660541", "id": "reaction_10479551", "reactome": "R-DME-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479517" ], "products": [ "species_10479549" ], "modifiers": [], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101" ] }, "reaction_10491346": { "compartment": "compartment_161320", "id": "reaction_10491346", "reactome": "R-DME-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491342", "species_10491338" ], "products": [ "species_10491336", "species_10491344" ], "modifiers": [], "additional_components": [ "FBgn0024320", "species_8848047", "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198", "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198", "species_8848047", "Q9VL24", "FBgn0024320" ] }, "reaction_10491348": { "compartment": "compartment_12045", "id": "reaction_10491348", "reactome": "R-DME-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491344" ], "products": [ "species_10491342", "species_193384" ], "modifiers": [], "additional_components": [ "species_8848047", "Q9VL24", "FBgn0024320", "FBgn0024320" ] }, "reaction_10491412": { "compartment": "compartment_12045", "id": "reaction_10491412", "reactome": "R-DME-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10491407", "catalyst" ] ], "additional_components": [ "FBgn0037612" ] }, "reaction_10491340": { "compartment": "compartment_161320", "id": "reaction_10491340", "reactome": "R-DME-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10491336" ], "products": [ "species_10491338" ], "modifiers": [], "additional_components": [ "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198", "species_8848047", "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198" ] }, "reaction_10437938": { "compartment": "compartment_74700", "id": "reaction_10437938", "reactome": "R-DME-171087", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437930" ], "products": [ "species_10437936" ], "modifiers": [], "additional_components": [ "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101" ] }, "reaction_10479553": { "compartment": "compartment_1660541", "id": "reaction_10479553", "reactome": "R-DME-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479549" ], "products": [ "species_10479547" ], "modifiers": [], "additional_components": [ "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380" ] }, "reaction_10490897": { "compartment": "compartment_70101", "id": "reaction_10490897", "reactome": "R-DME-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10490631" ], "products": [ "species_10490894", "species_10490892", "species_1132084" ], "modifiers": [ [ "species_10490631", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "Q9V8W3", "FBgn0026378", "O18335", "FBgn0015790", "A1Z7S3", "FBgn0002567", "Q9V3I2", "FBgn0014010", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "O18333", "FBgn0014009", "Q9VQG6", "FBgn0031460", "O18338", "FBgn0262518", "Q9VZ47", "FBgn0052671", "Q8IR98", "FBgn0052670", "Q9W2S9", "FBgn0030221", "Q8IRK8", "FBgn0052673", "Q9W2V3", "FBgn0030200", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "P25228", "FBgn0005586", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420" ] }, "reaction_10490498": { "compartment": "compartment_70101", "id": "reaction_10490498", "reactome": "R-DME-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10490490", "species_10485779" ], "products": [ "species_10490496" ], "modifiers": [], "additional_components": [ "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "FBgn0026378", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164" ] }, "reaction_10490633": { "compartment": "compartment_70101", "id": "reaction_10490633", "reactome": "R-DME-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490629", "species_10490496" ], "products": [ "species_10490631" ], "modifiers": [], "additional_components": [ "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420" ] }, "reaction_10490492": { "compartment": "compartment_70101", "id": "reaction_10490492", "reactome": "R-DME-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490488", "species_10490486" ], "products": [ "species_10490490" ], "modifiers": [], "additional_components": [ "FBgn0028970", "FBgn0037293", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970" ] }, "reaction_10468651": { "compartment": "compartment_70101", "id": "reaction_10468651", "reactome": "R-DME-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468647", "species_10468649" ], "products": [ "species_10468516" ], "modifiers": [], "additional_components": [ "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474" ] }, "reaction_10468521": { "compartment": "compartment_70101", "id": "reaction_10468521", "reactome": "R-DME-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468516" ], "products": [ "species_29372", "species_10468518" ], "modifiers": [ [ "species_10468516", "catalyst" ], [ "species_10468514", "catalyst" ] ], "additional_components": [ "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474" ] }, "reaction_10498696": { "compartment": "compartment_70101", "id": "reaction_10498696", "reactome": "R-DME-9705925", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8979218", "species_10473503" ], "products": [ "species_10498694" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849" ] }, "reaction_10498553": { "compartment": "compartment_70101", "id": "reaction_10498553", "reactome": "R-DME-9690534", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473346", "species_5618094" ], "products": [ "species_10473348" ], "modifiers": [ [ "species_10498474", "catalyst" ] ], "additional_components": [ "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849" ] }, "reaction_10468612": { "compartment": "compartment_70101", "id": "reaction_10468612", "reactome": "R-DME-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468518", "species_10468600", "species_10468604" ], "products": [ "species_10468514", "species_10468610" ], "modifiers": [], "additional_components": [ "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "FBgn0024352", "P02828", "FBgn0001233", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "P02828", "FBgn0001233", "Q9VPN5", "FBgn0024352", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878" ] }, "reaction_10473507": { "compartment": "compartment_70101", "id": "reaction_10473507", "reactome": "R-DME-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468610", "species_113592" ], "products": [ "species_10473495" ], "modifiers": [], "additional_components": [ "P02828", "FBgn0001233", "Q9VPN5", "FBgn0024352", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VPN5", "FBgn0024352", "P02828", "FBgn0001233", "species_113592" ] }, "reaction_10498476": { "compartment": "compartment_70101", "id": "reaction_10498476", "reactome": "R-DME-9678925", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473346", "species_9678859" ], "products": [ "species_10498474" ], "modifiers": [], "additional_components": [ "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849" ] }, "reaction_10473490": { "compartment": "compartment_70101", "id": "reaction_10473490", "reactome": "R-DME-5618080", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473348", "species_10473342" ], "products": [ "species_10473360", "species_10473364" ], "modifiers": [ [ "species_10473488", "catalyst" ] ], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q8WS79", "FBgn0035849", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q9VH95", "FBgn0037728", "species_113592", "Q9VH95", "FBgn0037728", "species_193055", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "species_193977", "CHEBI:27584", "CHEBI:16973", "P02828", "FBgn0001233", "species_113592", "species_469662", "species_193977", "species_193055", "CHEBI:27584", "CHEBI:16973", "species_193057", "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420" ] }, "reaction_10473505": { "compartment": "compartment_70101", "id": "reaction_10473505", "reactome": "R-DME-5618099", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5618094", "species_10473503" ], "products": [ "species_10473342" ], "modifiers": [], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q8WS79", "FBgn0035849", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q9VH95", "FBgn0037728", "species_113592" ] }, "reaction_10498428": { "compartment": "compartment_7660", "id": "reaction_10498428", "reactome": "R-DME-9668902", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427600", "species_10438451", "species_10427605", "species_10427610", "species_10427615" ], "products": [ "species_10438453" ], "modifiers": [], "additional_components": [ "FBgn0032244", "Q2PDX2", "FBgn0054001", "Q8IQ05", "FBgn0015376", "Q4V3Z5", "FBgn0034495", "FBgn0030871", "FBgn0028700", "FBgn0260985", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q2PDX2", "FBgn0054001", "Q8IQ05", "FBgn0015376", "Q4V3Z5", "FBgn0034495", "Q9VKW3", "FBgn0032244" ] }, "reaction_10498430": { "compartment": "compartment_7660", "id": "reaction_10498430", "reactome": "R-DME-9668904", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438449", "species_10438439", "species_10438444" ], "products": [ "species_10438451" ], "modifiers": [], "additional_components": [ "FBgn0034495", "FBgn0015376", "FBgn0054001", "Q2PDX2", "FBgn0054001", "Q8IQ05", "FBgn0015376", "Q4V3Z5", "FBgn0034495" ] }, "reaction_10442443": { "compartment": "compartment_70101", "id": "reaction_10442443", "reactome": "R-DME-204647", "name": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_10442429", "species_29360" ], "products": [ "species_70106", "species_204628", "species_10442425", "species_73473" ], "modifiers": [ [ "species_10442438", "catalyst" ] ], "additional_components": [ "FBgn0285952", "FBgn0285952", "Q9VSF4", "FBgn0035854" ] }, "reaction_10442458": { "compartment": "compartment_70101", "id": "reaction_10442458", "reactome": "R-DME-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10442425", "species_73473" ], "products": [ "species_29356", "species_10442446", "species_29360" ], "modifiers": [ [ "species_10442455", "catalyst" ] ], "additional_components": [ "FBgn0285952", "FBgn0285952", "Q9V9U4", "FBgn0261479", "species_111793" ] }, "reaction_10445932": { "compartment": "compartment_12045", "id": "reaction_10445932", "reactome": "R-DME-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445921" ], "products": [ "species_10445930" ], "modifiers": [], "additional_components": [ "FBgn0037327", "Q9NIV1", "FBgn0037327" ] }, "reaction_10445957": { "compartment": "compartment_70101", "id": "reaction_10445957", "reactome": "R-DME-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430457" ], "products": [ "species_10445954", "species_29370" ], "modifiers": [ [ "species_10445930", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q9NIV1", "FBgn0037327" ] }, "reaction_10476175": { "compartment": "compartment_70101", "id": "reaction_10476175", "reactome": "R-DME-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10476172", "catalyst" ] ], "additional_components": [ "FBgn0086768" ] }, "reaction_10476167": { "compartment": "compartment_70101", "id": "reaction_10476167", "reactome": "R-DME-5676917", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_5676932" ], "products": [ "species_10430994", "species_174390" ], "modifiers": [ [ "species_10476162", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "FBgn0267376" ] }, "reaction_10461449": { "compartment": "compartment_70101", "id": "reaction_10461449", "reactome": "R-DME-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461443", "species_10461445" ], "products": [ "species_10461447" ], "modifiers": [], "additional_components": [ "Q9VSS2", "FBgn0035947", "P49963", "FBgn0015298", "Q9VSC1", "FBgn0035827", "Q9VDL0", "FBgn0038808", "Q9VDK7", "FBgn0038810", "Q9V3D9", "FBgn0010747", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VSS2", "FBgn0035947", "P49963", "FBgn0015298", "Q9VSC1", "FBgn0035827", "Q9VDL0", "FBgn0038808", "Q9VDK7", "FBgn0038810", "Q9V3D9", "FBgn0010747" ] }, "reaction_10494849": { "compartment": "compartment_70101", "id": "reaction_10494849", "reactome": "R-DME-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493819", "species_10494824", "species_10493698" ], "products": [ "species_10494826" ], "modifiers": [], "additional_components": [ "Q9VUQ8", "FBgn0036510", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510" ] }, "reaction_10495201": { "compartment": "compartment_70101", "id": "reaction_10495201", "reactome": "R-DME-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495188" ], "products": [ "species_10495198", "species_10477768" ], "modifiers": [ [ "species_10489634", "catalyst" ] ], "additional_components": [ "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "A1ZBY1", "FBgn0034542", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9VJ33", "FBgn0032725", "Q9VAQ0", "FBgn0039632", "Q7JWH5", "FBgn0044020", "Q9VVB4", "FBgn0036671", "Q9VUQ8", "FBgn0036510", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9V9R2", "FBgn0032956", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "A1ZBY1", "FBgn0034542", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "Q9VAQ0", "FBgn0039632", "Q7JWH5", "FBgn0044020", "FBgn0032725", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836" ] }, "reaction_10494949": { "compartment": "compartment_7660", "id": "reaction_10494949", "reactome": "R-DME-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494922" ], "products": [ "species_10494924", "species_10494946" ], "modifiers": [ [ "species_10494922", "catalyst" ] ], "additional_components": [ "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "FBgn0035853", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9VJ33", "FBgn0032725", "Q5BI50", "FBgn0033260", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853" ] }, "reaction_10495238": { "compartment": "compartment_70101", "id": "reaction_10495238", "reactome": "R-DME-8956140", "name": "NEDD8 and UBD bind NUB1 and the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427203", "species_10477768", "species_10495234" ], "products": [ "species_10495236" ], "modifiers": [], "additional_components": [ "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "FBgn0032725", "FBgn0039343", "Q9VBQ3", "FBgn0039343", "Q9VJ33", "FBgn0032725", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10494951": { "compartment": "compartment_7660", "id": "reaction_10494951", "reactome": "R-DME-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494920", "species_10494855", "species_10494912" ], "products": [ "species_10494922" ], "modifiers": [], "additional_components": [ "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853" ] }, "reaction_10495208": { "compartment": "compartment_7660", "id": "reaction_10495208", "reactome": "R-DME-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494946" ], "products": [ "species_10495205", "species_10495203" ], "modifiers": [ [ "species_10477930", "catalyst" ] ], "additional_components": [ "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9VJ33", "FBgn0032725", "Q5BI50", "FBgn0033260", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VVB4", "FBgn0036671", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "FBgn0032725", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057" ] }, "reaction_10495240": { "compartment": "compartment_70101", "id": "reaction_10495240", "reactome": "R-DME-8956184", "name": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495236" ], "products": [ "species_10427203", "species_10495234" ], "modifiers": [], "additional_components": [ "Q9VBQ3", "FBgn0039343", "Q9VJ33", "FBgn0032725", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "FBgn0039343" ] }, "reaction_10495242": { "compartment": "compartment_876", "id": "reaction_10495242", "reactome": "R-DME-8956200", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494842", "species_10494824" ], "products": [ "species_10494844" ], "modifiers": [], "additional_components": [ "FBgn0033784", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q8T8S1", "FBgn0033784" ] }, "reaction_10493675": { "compartment": "compartment_70101", "id": "reaction_10493675", "reactome": "R-DME-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477770" ], "products": [ "species_10477768", "species_10477759" ], "modifiers": [], "additional_components": [ "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725", "FBgn0032725", "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288" ] }, "reaction_10495122": { "compartment": "compartment_70101", "id": "reaction_10495122", "reactome": "R-DME-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495118", "species_10477966" ], "products": [ "species_10495120" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "A1ZBY1", "FBgn0034542", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "Q9VAQ0", "FBgn0039632", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q7JWH5", "FBgn0044020", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "Q9V9R2", "FBgn0032956", "FBgn0027568", "Q9VKY2", "FBgn0027568", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "A1ZBY1", "FBgn0034542", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "Q9VAQ0", "FBgn0039632", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q7JWH5", "FBgn0044020", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "Q9V9R2", "FBgn0032956" ] }, "reaction_10495219": { "compartment": "compartment_70101", "id": "reaction_10495219", "reactome": "R-DME-8956099", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495215", "species_10495210" ], "products": [ "species_10495217" ], "modifiers": [], "additional_components": [ "FBgn0031664", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q7K4I5", "FBgn0031664" ] }, "reaction_10495223": { "compartment": "compartment_70101", "id": "reaction_10495223", "reactome": "R-DME-8956103", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458032", "species_10495210" ], "products": [ "species_10495221" ], "modifiers": [], "additional_components": [ "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411" ] }, "reaction_10495128": { "compartment": "compartment_7660", "id": "reaction_10495128", "reactome": "R-DME-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494894", "species_10495124" ], "products": [ "species_10495126" ], "modifiers": [], "additional_components": [ "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "FBgn0027568", "Q9VKY2", "FBgn0027568", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962" ] }, "reaction_10495228": { "compartment": "compartment_70101", "id": "reaction_10495228", "reactome": "R-DME-8956106", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495221", "species_10458091" ], "products": [ "species_10495225", "species_10427563" ], "modifiers": [ [ "species_10495221", "catalyst" ], [ "species_10495217", "inhibitor" ] ], "additional_components": [ "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411", "Q9Y165", "FBgn0027609", "P25867", "eff", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q7K4I5", "FBgn0031664" ] }, "reaction_10494846": { "compartment": "compartment_70101", "id": "reaction_10494846", "reactome": "R-DME-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494826" ], "products": [ "species_10493677", "species_10494838" ], "modifiers": [ [ "species_10494826", "catalyst" ], [ "species_10494844", "inhibitor" ] ], "additional_components": [ "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510", "FBgn0035853", "Q24311", "Cul1", "Q9VJ33", "FBgn0032725", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VVB4", "FBgn0036671", "Q9VUQ8", "FBgn0036510", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q8T8S1", "FBgn0033784" ] }, "reaction_10489264": { "compartment": "compartment_984", "id": "reaction_10489264", "reactome": "R-DME-8855711", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855720", "species_10489260" ], "products": [ "species_10489262" ], "modifiers": [], "additional_components": [ "M9NE79", "FBgn0262357", "Q9VPS2", "FBgn0040107", "M9PB26", "FBgn0264341", "Q9VQ53", "FBgn0031373", "Q59DY5", "FBgn0053533", "Q9VQU4", "FBgn0040104", "Q59DY6", "FBgn0053532", "Q9VQX3", "FBgn0040102", "Q7JY62", "FBgn0040092", "Q9W3D8", "FBgn0030050", "A1Z7Z6", "FBgn0040093", "Q8IRH8", "FBgn0035199", "A1Z8L7", "FBgn0040503", "Q9VIX1", "FBgn0016675", "B4ZJ93", "FBgn0259958", "Q9VKL8", "FBgn0040096", "B7YZU7", "FBgn0259230", "Q9VLM0", "FBgn0040098", "B7Z0K3", "FBgn0038315", "Q9VM16", "FBgn0031910", "C3KGN2", "FBgn0283508", "Q9VPS1", "FBgn0040106", "M9NE79", "FBgn0262357", "Q9VPS2", "FBgn0040107", "M9PB26", "FBgn0264341", "Q9VQ53", "FBgn0031373", "Q59DY5", "FBgn0053533", "Q9VQU4", "FBgn0040104", "Q59DY6", "FBgn0053532", "Q9VQX3", "FBgn0040102", "Q7JY62", "FBgn0040092", "Q9W3D8", "FBgn0030050", "A1Z7Z6", "FBgn0040093", "Q8IRH8", "FBgn0035199", "A1Z8L7", "FBgn0040503", "Q9VIX1", "FBgn0016675", "B4ZJ93", "FBgn0259958", "Q9VKL8", "FBgn0040096", "B7YZU7", "FBgn0259230", "Q9VLM0", "FBgn0040098", "B7Z0K3", "FBgn0038315", "Q9VM16", "FBgn0031910", "C3KGN2", "FBgn0283508", "Q9VPS1", "FBgn0040106", "species_8855720" ] }, "reaction_10488819": { "compartment": "compartment_70101", "id": "reaction_10488819", "reactome": "R-DME-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10457705" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10488816", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "species_8853396", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "FBgn0030839" ] }, "reaction_10488392": { "compartment": "compartment_70101", "id": "reaction_10488392", "reactome": "R-DME-8850594", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10457705" ], "products": [ "species_1022114", "species_8852852" ], "modifiers": [ [ "species_10488389", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "CHEBI:60628", "CHEBI:60629", "species_964740", "species_915149", "CHEBI:60627", "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VCD5", "FBgn0039147", "Q9V3W9", "FBgn0026777", "Q7KRR5", "FBgn0033050", "Q9VSC5", "FBgn0035830", "P48601", "Rpt2" ] }, "reaction_10454410": { "compartment": "compartment_17957", "id": "reaction_10454410", "reactome": "R-DME-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454406", "species_10453353" ], "products": [ "species_10454408" ], "modifiers": [], "additional_components": [ "P29413", "FBgn0005585", "Q9I7S9", "FBgn0030377", "Q9VXF6", "FBgn0264077", "Q9VAL7", "FBgn0015622", "CHEBI:59080", "FBgn0033663", "Q3YMU0", "FBgn0033663", "P29413", "FBgn0005585", "Q9I7S9", "FBgn0030377", "Q9VXF6", "FBgn0264077", "Q9VAL7", "FBgn0015622", "CHEBI:59080" ] }, "reaction_10455485": { "compartment": "compartment_17963", "id": "reaction_10455485", "reactome": "R-DME-964759", "name": "Alternative endo-mannosidase I route", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964754" ], "products": [ "species_964744", "species_964746" ], "modifiers": [ [ "species_10455482", "catalyst" ] ], "additional_components": [ "FBgn0031716" ] }, "reaction_10455493": { "compartment": "compartment_20699", "id": "reaction_10455493", "reactome": "R-DME-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_964740" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10455490", "catalyst" ] ], "additional_components": [ "FBgn0034521" ] }, "reaction_10478044": { "compartment": "compartment_70101", "id": "reaction_10478044", "reactome": "R-DME-5693061", "name": "STAMBP binds STAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439062", "species_10478040" ], "products": [ "species_10478042" ], "modifiers": [], "additional_components": [ "FBgn0027363", "FBgn0039773", "Q9VA71", "FBgn0039773", "Q9XTL2", "FBgn0027363" ] }, "reaction_10479159": { "compartment": "compartment_70101", "id": "reaction_10479159", "reactome": "R-DME-5696547", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437507" ], "products": [ "species_10437505" ], "modifiers": [ [ "species_10479156", "catalyst" ], [ "species_10478042", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0039773", "Q9VA71", "FBgn0039773", "Q9XTL2", "FBgn0027363" ] }, "reaction_10477973": { "compartment": "compartment_70101", "id": "reaction_10477973", "reactome": "R-DME-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437507" ], "products": [ "species_10437505" ], "modifiers": [ [ "species_10426995", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10435837": { "compartment": "compartment_17957", "id": "reaction_10435837", "reactome": "R-DME-159761", "name": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_6806362", "species_159751", "species_10435823" ], "products": [ "species_113519", "species_10435829", "species_6806366" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10435960": { "compartment": "compartment_17957", "id": "reaction_10435960", "reactome": "R-DME-159803", "name": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10435952", "species_6806362", "species_159751" ], "products": [ "species_113519", "species_6806366", "species_10435958" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10436711": { "compartment": "compartment_17957", "id": "reaction_10436711", "reactome": "R-DME-163820", "name": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_6806362", "species_159751", "species_10436703" ], "products": [ "species_113519", "species_10436709", "species_6806366" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10435926": { "compartment": "compartment_17957", "id": "reaction_10435926", "reactome": "R-DME-159795", "name": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_6806362", "species_10435924", "species_159751" ], "products": [ "species_113519", "species_6806366", "species_10435863" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10435970": { "compartment": "compartment_17957", "id": "reaction_10435970", "reactome": "R-DME-159819", "name": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10435968", "species_6806362", "species_159751" ], "products": [ "species_113519", "species_6806366", "species_10435815" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10436719": { "compartment": "compartment_20699", "id": "reaction_10436719", "reactome": "R-DME-163843", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436695" ], "products": [ "species_10436715", "species_10436717" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "FBgn0027594", "FBgn0027594", "FBgn0027594", "FBgn0004509" ] }, "reaction_10435946": { "compartment": "compartment_20699", "id": "reaction_10435946", "reactome": "R-DME-159796", "name": "Furin cleaves pro-factor IX to factor IX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435932" ], "products": [ "species_10435938", "species_10435944" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10435801": { "compartment": "compartment_20699", "id": "reaction_10435801", "reactome": "R-DME-159733", "name": "Furin cleaves pro-factor X to factor X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435779" ], "products": [ "species_10435793", "species_10435787" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10435895": { "compartment": "compartment_20699", "id": "reaction_10435895", "reactome": "R-DME-159771", "name": "Furin cleaves pro-protein C to protein C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435877" ], "products": [ "species_10435893", "species_10435887" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10436677": { "compartment": "compartment_20699", "id": "reaction_10436677", "reactome": "R-DME-163798", "name": "Furin cleaves pro-protein Z to protein Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436663" ], "products": [ "species_10436675", "species_10436669" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10435986": { "compartment": "compartment_20699", "id": "reaction_10435986", "reactome": "R-DME-159868", "name": "Furin cleaves pro-factor VII to factor VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435901" ], "products": [ "species_10435984", "species_10435978" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10480016": { "compartment": "compartment_12045", "id": "reaction_10480016", "reactome": "R-DME-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_71285", "species_6788758" ], "modifiers": [ [ "species_10480013", "catalyst" ] ], "additional_components": [ "Q9VU37", "FBgn0036336", "species_1562550" ] }, "reaction_10494803": { "compartment": "compartment_17957", "id": "reaction_10494803", "reactome": "R-DME-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494300", "species_8931885" ], "products": [ "species_10494796", "species_8931884" ], "modifiers": [ [ "species_10494300", "catalyst" ], [ "species_10494801", "catalyst" ] ], "additional_components": [ "A4VCL2", "FBgn0051145", "P54399", "FBgn0286818", "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649", "Q9VP10", "FBgn0037105", "Q9VTZ5", "FBgn0036299", "Q9VJW9", "FBgn0259984", "Q9VLC3", "FBgn0032116", "Q9VX11", "FBgn0052557", "Q9VBK7", "FBgn0039387", "Q9VM47", "FBgn0031885", "Q9V416", "FBgn0028879", "P14599", "FBgn0000108", "Q9VVK3", "FBgn0052183", "Q9VHA8", "FBgn0037718", "Q9VUH4", "FBgn0036446", "Q9VUH5", "FBgn0036447", "Q9VDT9", "FBgn0014135", "Q9VMA7", "FBgn0286898", "Q9VUX3", "FBgn0044028", "P27091", "FBgn0024234", "P54631", "FBgn0005590", "Q9V4E6", "FBgn0039914", "P07713", "FBgn0000490", "Q9VVK7", "FBgn0052190", "Q9V438", "FBgn0025678", "E1JI03", "FBgn0036449", "Q9W302", "FBgn0030163", 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"Q9VJW9", "FBgn0259984", "Q9VLC3", "FBgn0032116", "Q9VX11", "FBgn0052557", "Q9VBK7", "FBgn0039387", "Q9VM47", "FBgn0031885", "Q9V416", "FBgn0028879", "P14599", "FBgn0000108", "Q9VVK3", "FBgn0052183", "Q9VHA8", "FBgn0037718", "Q9VUH4", "FBgn0036446", "Q9VUH5", "FBgn0036447", "Q9VDT9", "FBgn0014135", "Q9VMA7", "FBgn0286898", "Q9VUX3", "FBgn0044028", "P27091", "FBgn0024234", "P54631", "FBgn0005590", "Q9V4E6", "FBgn0039914", "P07713", "FBgn0000490", "Q9VVK7", "FBgn0052190", "Q9V438", "FBgn0025678", "E1JI03", "FBgn0036449", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "B7Z0B2", "FBgn0035452", "Q7KT80", "FBgn0051832", "Q8IRM2", "FBgn0030164", "Q95SM8", "FBgn0050281", "Q9VME7", "FBgn0031804", "Q9VX04", "FBgn0030880", "Q9VLT3", "FBgn0267488", "Q9VLY7", "FBgn0041181", "M9PDR0", "FBgn0041180", "Q9NFV7", "FBgn0041182", "Q9NFV8", "FBgn0041183", "Q9VJD1", "FBgn0032643", "Q9VTJ4", "FBgn0285958", "Q9W0A0", "FBgn0027594", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q24114", "dally", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "O97365", "FBgn0026562", "P11046", "FBgn0261800", "Q7JQR3", "FBgn0033814", "Q9VWV6", "FBgn0022355", "Q9VAY2", "FBgn0039562", "Q9VH14", "FBgn0025879", "P15215", "FBgn0267348", "P49415", "FBgn0010415", "X2JEB0", "FBgn0262730", "Q9W0H8", "FBgn0025682", "Q9VJB6", "FBgn0262018", "Q8IMZ9", "FBgn0039003", "Q9VPI6", "FBgn0031213", "Q9VPI7", "FBgn0031214", "Q9VPU6", "FBgn0031289", "A4VCL2", "FBgn0051145" ] }, "reaction_10444863": { "compartment": "compartment_876", "id": "reaction_10444863", "reactome": "R-DME-374922", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10444851", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10444853" ], "modifiers": [ [ "species_10444851", "catalyst" ] ], "additional_components": [ "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964" ] }, "reaction_10444858": { "compartment": "compartment_984", "id": "reaction_10444858", "reactome": "R-DME-374899", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444853" ], "products": [ "species_10443025", "species_10442919", "species_10444855", "species_10443003", "species_10443019", "species_10442973", "species_374935", "species_10443023" ], "modifiers": [ [ "species_10444853", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0004574", "FBgn0260964", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343" ] }, "reaction_10444371": { "compartment": "compartment_374932", "id": "reaction_10444371", "reactome": "R-DME-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10444368", "catalyst" ] ], "additional_components": [ "FBgn0260964" ] }, "reaction_10496500": { "compartment": "compartment_70101", "id": "reaction_10496500", "reactome": "R-DME-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8982080", "species_10467519" ], "products": [ "species_10496498" ], "modifiers": [], "additional_components": [ "CHEBI:49537", "CHEBI:47037", "FBgn0015331", "Q9V3C0", "FBgn0015331", "CHEBI:49537", "CHEBI:47037" ] }, "reaction_10468991": { "compartment": "compartment_7660", "id": "reaction_10468991", "reactome": "R-DME-3788725", "name": "Cdh1:APC/C complex binds EHMT1:EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468978", "species_10438214" ], "products": [ "species_10468980" ], "modifiers": [], "additional_components": [ "M9PGH7", "FBgn0040372", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "M9PGH7", "FBgn0040372" ] }, "reaction_10468989": { "compartment": "compartment_7660", "id": "reaction_10468989", "reactome": "R-DME-3788724", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468980", "species_10427430" ], "products": [ "species_10468986" ], "modifiers": [ [ "species_10468980", "catalyst" ] ], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "M9PGH7", "FBgn0040372", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "M9PGH7", "FBgn0040372", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "M9PGH7", "FBgn0040372" ] }, "reaction_10468969": { "compartment": "compartment_7660", "id": "reaction_10468969", "reactome": "R-DME-3788708", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438214", "species_10427405" ], "products": [ "species_10438216" ], "modifiers": [ [ "species_10439439", "inhibitor" ] ], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107" ] }, "reaction_10469079": { "compartment": "compartment_7660", "id": "reaction_10469079", "reactome": "R-DME-3857336", "name": "CEBPB homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469061" ], "products": [ "species_10469063" ], "modifiers": [], "additional_components": [ "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493" ] }, "reaction_10468966": { "compartment": "compartment_7660", "id": "reaction_10468966", "reactome": "R-DME-3788705", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438216" ], "products": [ "species_113582", "species_10438218" ], "modifiers": [ [ "species_10438216", "catalyst" ], [ "species_10439439", "inhibitor" ] ], "additional_components": [ "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107" ] }, "reaction_10469077": { "compartment": "compartment_7660", "id": "reaction_10469077", "reactome": "R-DME-3857329", "name": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10469069" ], "products": [ "species_113582", "species_10469075" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "P40417", "FBgn0003256" ] }, "reaction_10447725": { "compartment": "compartment_876", "id": "reaction_10447725", "reactome": "R-DME-420980", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10446959", "catalyst" ] ], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_10447723": { "compartment": "compartment_984", "id": "reaction_10447723", "reactome": "R-DME-420977", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10446957" ], "products": [ "species_10446959" ], "modifiers": [], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_10447721": { "compartment": "compartment_984", "id": "reaction_10447721", "reactome": "R-DME-420975", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10446946" ], "products": [ "species_10446948" ], "modifiers": [], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_10446951": { "compartment": "compartment_876", "id": "reaction_10446951", "reactome": "R-DME-399711", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10446948", "catalyst" ] ], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_350405": { "compartment": "compartment_876", "id": "reaction_350405", "reactome": "R-DME-350405", "name": "RHOGEF2 binds to RHO1:GDP complex at the plasma membrane", "reversible": "false", "notes": "At the plasma membrane, Rho guanyl-nucleotide exchange factor (RHOGEF2) associates with the inactive Rho GTPase complex (RHO1:GDP).", "reactants": [ "species_350999", "species_350951" ], "products": [ "species_351056" ], "modifiers": [], "additional_components": [ "species_29420", "P48148", "Rho1", "O44113", "RHOGEF2", "species_29420", "P48148", "Rho1" ] }, "reaction_350453": { "compartment": "compartment_70101", "id": "reaction_350453", "reactome": "R-DME-350453", "name": "RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane", "reversible": "false", "notes": "Rho GTPase activator (RHOGAPP190) associates with the activated Rho GTPase complex (RHO1:GTP) at the plasma membrane.", "reactants": [ "species_350991", "species_350950" ], "products": [ "species_351000" ], "modifiers": [], "additional_components": [ "species_29438", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "Q9VX32", "RhoGAPp190" ] }, "reaction_350359": { "compartment": "compartment_70101", "id": "reaction_350359", "reactome": "R-DME-350359", "name": "RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane", "reversible": "false", "notes": "Inactive Rho GTPase complex (RHO1:GDP) dissociates from Rho GDP dissociation inhibitor (RHOGDI) and binds to the plasma membrane.", "reactants": [ "species_351058" ], "products": [ "species_351008", "species_350999" ], "modifiers": [], "additional_components": [ "Q9VW59", "RhoGDI", "species_29420", "P48148", "Rho1", "species_29420", "P48148", "Rho1" ] }, "reaction_350450": { "compartment": "compartment_876", "id": "reaction_350450", "reactome": "R-DME-350450", "name": "RHO1:GTP complex dissociates from RHOGEF2", "reversible": "false", "notes": "Rho guanyl-nucleotide exchange factor (RHOGEF2) dissociates from the activated Rho GTPase complex (RHO1:GTP).", "reactants": [ "species_351086" ], "products": [ "species_350950", "species_350951" ], "modifiers": [], "additional_components": [ "O44113", "RHOGEF2", "species_29438", "P48148", "Rho1", "species_29438", "P48148", "Rho1" ] }, "reaction_350477": { "compartment": "compartment_70101", "id": "reaction_350477", "reactome": "R-DME-350477", "name": "RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex", "reversible": "false", "notes": "Rho guanyl-nucleotide exchange factor (RHOGEF2) catalyses GTP for GDP nucleotide exchange with the Rho GTPase complex (RHO1:GDP).", "reactants": [ "species_29438", "species_351056" ], "products": [ "species_29420", "species_351086" ], "modifiers": [ [ "species_351056", "catalyst" ] ], "additional_components": [ "O44113", "RHOGEF2", "species_29420", "P48148", "Rho1", "O44113", "RHOGEF2", "species_29438", "P48148", "Rho1", "O44113", "RHOGEF2", "species_29420", "P48148", "Rho1" ] }, "reaction_350395": { "compartment": "compartment_70101", "id": "reaction_350395", "reactome": "R-DME-350395", "name": "RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol", "reversible": "false", "notes": "Rho GDP dissociation inhibitor (RHOGDI) sequesters inactive Rho GTPase complex (RHO1:GDP) in the cytosol.", "reactants": [ "species_351008", "species_350999" ], "products": [ "species_351058" ], "modifiers": [], "additional_components": [ "species_29420", "P48148", "Rho1", "Q9VW59", "RhoGDI", "species_29420", "P48148", "Rho1" ] }, "reaction_350458": { "compartment": "compartment_70101", "id": "reaction_350458", "reactome": "R-DME-350458", "name": "RHOGAPP190 activates GTP hydrolysis by RHO1:GTP", "reversible": "false", "notes": "RHOGAPP190 activates the GTPase activity of RHO1, leading to hydrolysis of its bound GTP.", "reactants": [ "species_351000" ], "products": [ "species_29372", "species_351009" ], "modifiers": [ [ "species_351000", "catalyst" ] ], "additional_components": [ "species_29438", "P48148", "Rho1", "Q9VX32", "RhoGAPp190", "species_29420", "P48148", "Rho1", "Q9VX32", "RhoGAPp190", "species_29438", "P48148", "Rho1", "Q9VX32", "RhoGAPp190" ] }, "reaction_350410": { "compartment": "compartment_70101", "id": "reaction_350410", "reactome": "R-DME-350410", "name": "RHO1:GDP complex dissociates from RHOGAPP190", "reversible": "false", "notes": "Rho GTPase activator (RHOGAPP190) dissociates from inactive Rho GTPase complex(RHO1:GDP).", "reactants": [ "species_351009" ], "products": [ "species_350991", "species_350999" ], "modifiers": [], "additional_components": [ "species_29420", "P48148", "Rho1", "Q9VX32", "RhoGAPp190", "species_29420", "P48148", "Rho1" ] }, "reaction_10470223": { "compartment": "compartment_70101", "id": "reaction_10470223", "reactome": "R-DME-4793925", "name": "p-S303,307-HSF1 binds YWHAE (14-3-3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432016", "species_10470219" ], "products": [ "species_10470221" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "FBgn0001222", "P22813", "FBgn0001222", "P92177", "14-3-3epsilon" ] }, "reaction_10471487": { "compartment": "compartment_70101", "id": "reaction_10471487", "reactome": "R-DME-5252079", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471418" ], "products": [ "species_29370", "species_10471276" ], "modifiers": [ [ "species_10471470", "catalyst" ], [ "species_10471485", "inhibitor" ] ], "additional_components": [ "species_29370", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "M9MSL3", "FBgn0026418", "A8JNS4", "FBgn0086708", "Q95RY2", "FBgn0036505", "Q86DS1", "FBgn0029676", "C4NYP8", "FBgn0260484" ] }, "reaction_10471450": { "compartment": "compartment_70101", "id": "reaction_10471450", "reactome": "R-DME-5252041", "name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471278" ], "products": [ "species_10471354" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9W0C7", "FBgn0035243", "Q9W0C7", "FBgn0035243", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "species_113592", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10470217": { "compartment": "compartment_70101", "id": "reaction_10470217", "reactome": "R-DME-4793911", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468527" ], "products": [ "species_29370", "species_10470214" ], "modifiers": [ [ "species_10439409", "catalyst" ] ], "additional_components": [ "FBgn0001222", "FBgn0001222", "FBgn0013987" ] }, "reaction_10471528": { "compartment": "compartment_7660", "id": "reaction_10471528", "reactome": "R-DME-5333051", "name": "RPA1 binds HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_10468620" ], "products": [ "species_10471526" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P22813", "FBgn0001222", "P22813", "FBgn0001222", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10471429": { "compartment": "compartment_70101", "id": "reaction_10471429", "reactome": "R-DME-5251959", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10471276" ], "products": [ "species_29372", "species_10471418" ], "modifiers": [ [ "species_10471426", "catalyst" ] ], "additional_components": [ "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_29370", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VP77", "FBgn0037051", "A8DYF7", "FBgn0034091", "Q9V3W1", "FBgn0032586" ] }, "reaction_10468628": { "compartment": "compartment_70101", "id": "reaction_10468628", "reactome": "R-DME-3371531", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468527" ], "products": [ "species_10468626", "species_29370" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "FBgn0001222", "FBgn0001222", "P40417", "FBgn0003256" ] }, "reaction_10468532": { "compartment": "compartment_70101", "id": "reaction_10468532", "reactome": "R-DME-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468527" ], "products": [ "species_10468530", "species_29370" ], "modifiers": [ [ "species_10440540", "catalyst" ] ], "additional_components": [ "FBgn0001222", "FBgn0001222", "P83101", "FBgn0046332", "P18431", "sgg" ] }, "reaction_10471396": { "compartment": "compartment_7660", "id": "reaction_10471396", "reactome": "R-DME-5251955", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10471354" ], "products": [ "species_113550", "species_10471376", "species_10471352" ], "modifiers": [ [ "species_10471393", "catalyst" ] ], "additional_components": [ "Q9W0C7", "FBgn0035243", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "species_113592", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "species_29370", "FBgn0035243", "Q9V3W1", "FBgn0032586", "Q9VP77", "FBgn0037051", "A8DYF7", "FBgn0034091" ] }, "reaction_10471280": { "compartment": "compartment_70101", "id": "reaction_10471280", "reactome": "R-DME-5251942", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471200", "species_10471276" ], "products": [ "species_10471278" ], "modifiers": [], "additional_components": [ "FBgn0035243", "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9W0C7", "FBgn0035243" ] }, "reaction_10498679": { "compartment": "compartment_7660", "id": "reaction_10498679", "reactome": "R-DME-9699579", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441099" ], "products": [ "species_113582", "species_10441113" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10497384": { "compartment": "compartment_70101", "id": "reaction_10497384", "reactome": "R-DME-9607304", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475840", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P26675", "Sos" ] }, "reaction_10454271": { "compartment": "compartment_70101", "id": "reaction_10454271", "reactome": "R-DME-879914", "name": "IL3 stimulation induces Vav binding to Tec kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442646", "species_10442471" ], "products": [ "species_10454269" ], "modifiers": [], "additional_components": [ "FBgn0003502", "FBgn0040068", "Q9NHV9", "FBgn0040068", "P08630", "FBgn0003502" ] }, "reaction_10454509": { "compartment": "compartment_70101", "id": "reaction_10454509", "reactome": "R-DME-912790", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454432", "species_10446146" ], "products": [ "species_10454503" ], "modifiers": [], "additional_components": [ "FBgn0020224", "FBgn0024811", "Q9XYM0", "FBgn0024811", "Q9VSK2", "FBgn0020224" ] }, "reaction_10454507": { "compartment": "compartment_70101", "id": "reaction_10454507", "reactome": "R-DME-912734", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446160", "species_10454503" ], "products": [ "species_10454505" ], "modifiers": [], "additional_components": [ "FBgn0259228", "Q9XYM0", "FBgn0024811", "Q9VSK2", "FBgn0020224", "Q9XYM0", "FBgn0024811", "Q9VSK2", "FBgn0020224", "O77086", "FBgn0259228" ] }, "reaction_10454281": { "compartment": "compartment_70101", "id": "reaction_10454281", "reactome": "R-DME-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444516", "species_10453140", "species_10439032", "species_10431791" ], "products": [ "species_10454279" ], "modifiers": [], "additional_components": [ "FBgn0262733", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "FBgn0020224", "FBgn0004638", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P00528", "FBgn0262733" ] }, "reaction_10454501": { "compartment": "compartment_70101", "id": "reaction_10454501", "reactome": "R-DME-912727", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454432", "species_10442471" ], "products": [ "species_10454499" ], "modifiers": [], "additional_components": [ "FBgn0020224", "FBgn0040068", "Q9NHV9", "FBgn0040068", "Q9VSK2", "FBgn0020224" ] }, "reaction_10454497": { "compartment": "compartment_70101", "id": "reaction_10454497", "reactome": "R-DME-912627", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454480", "species_10454434" ], "products": [ "species_10454495" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P00528", "FBgn0262733", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "P00528", "FBgn0262733", "Q9VSK2", "FBgn0020224" ] }, "reaction_10495825": { "compartment": "compartment_70101", "id": "reaction_10495825", "reactome": "R-DME-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495805" ], "products": [ "species_10495823" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495817": { "compartment": "compartment_70101", "id": "reaction_10495817", "reactome": "R-DME-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495811" ], "products": [ "species_10495815" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495819": { "compartment": "compartment_70101", "id": "reaction_10495819", "reactome": "R-DME-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495809" ], "products": [ "species_10495811" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10495807": { "compartment": "compartment_70101", "id": "reaction_10495807", "reactome": "R-DME-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493643" ], "products": [ "species_10495805" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10450767": { "compartment": "compartment_70101", "id": "reaction_10450767", "reactome": "R-DME-449073", "name": "Caspase-3 cleaves pro-interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450760" ], "products": [ "species_10450762", "species_10450764" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0087007", "FBgn0087007", "FBgn0087007", "Q9XYF4", "FBgn0026404" ] }, "reaction_10496506": { "compartment": "compartment_984", "id": "reaction_10496506", "reactome": "R-DME-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450776", "species_10496502" ], "products": [ "species_10496504" ], "modifiers": [], "additional_components": [ "FBgn0039379", "FBgn0013343", "Q24547", "FBgn0013343", "Q9VBL3", "FBgn0039379" ] }, "reaction_10450771": { "compartment": "compartment_984", "id": "reaction_10450771", "reactome": "R-DME-449077", "name": "Interleukin-16 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450764" ], "products": [ "species_10450769" ], "modifiers": [], "additional_components": [ "FBgn0087007", "FBgn0087007" ] }, "reaction_10450786": { "compartment": "compartment_984", "id": "reaction_10450786", "reactome": "R-DME-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10450776" ], "products": [ "species_10450778" ], "modifiers": [ [ "species_10450784", "inhibitor" ] ], "additional_components": [ "FBgn0013343", "FBgn0039379", "Q9VBL3", "FBgn0039379", "Q24547", "FBgn0013343", "Q07327", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343" ] }, "reaction_10493651": { "compartment": "compartment_70101", "id": "reaction_10493651", "reactome": "R-DME-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493647" ], "products": [ "species_10493649" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493665": { "compartment": "compartment_70101", "id": "reaction_10493665", "reactome": "R-DME-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718", "species_10454425" ], "products": [ "species_10457722" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10493659": { "compartment": "compartment_70101", "id": "reaction_10493659", "reactome": "R-DME-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457722" ], "products": [ "species_10457730" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493640": { "compartment": "compartment_70101", "id": "reaction_10493640", "reactome": "R-DME-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493634" ], "products": [ "species_10493638" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493661": { "compartment": "compartment_70101", "id": "reaction_10493661", "reactome": "R-DME-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493632" ], "products": [ "species_10493634" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10475576": { "compartment": "compartment_70101", "id": "reaction_10475576", "reactome": "R-DME-5668520", "name": "26Sproteasome degrades K48polyUb-NIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475574" ], "products": [], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0024329", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_451846": { "compartment": "compartment_70101", "id": "reaction_451846", "reactome": "R-DME-451846", "name": "LFT binds to FT and DS", "reversible": "false", "notes": "The small protein Lowfat (LFT) binds to the cytoplasmic domains of the cadherin domain containing transmembrane proteins Fat (FT) and Dachsous (DS). The function of LFT is currently unknown but it does appear to increase FT and DS protein levels.", "reactants": [ "species_451851", "species_451871" ], "products": [ "species_451879" ], "modifiers": [], "additional_components": [ "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "Q9VKY1", "LFT" ] }, "reaction_451858": { "compartment": "compartment_70101", "id": "reaction_451858", "reactome": "R-DME-451858", "name": "YKI binds to HPO homodimer", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Hippo (HPO) homodimer PPXY sequence motif, of which HPO has one per monomer unit. YKI remains in the cytosol where it is unable to activate its target genes.", "reactants": [ "species_390185", "species_390114" ], "products": [ "species_451843" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q45VV3", "yki", "Q8T0S6", "HPO" ] }, "reaction_451826": { "compartment": "compartment_70101", "id": "reaction_451826", "reactome": "R-DME-451826", "name": "YKI binds to EX", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Expanded (EX) PPXY sequence motif, of which EX has three. YKI remains in the cytosol where it is unable to activate its target genes.", "reactants": [ "species_390114", "species_451874" ], "products": [ "species_451822" ], "modifiers": [], "additional_components": [ "Q07436", "EX", "Q45VV3", "yki" ] }, "reaction_451811": { "compartment": "compartment_70101", "id": "reaction_451811", "reactome": "R-DME-451811", "name": "YKI binds to WTS", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Warts (WTS) PPXY sequence motif, of which WTS has five. YKI remains in the cytosol where it is unable to activate its target genes.", "reactants": [ "species_390114", "species_390037" ], "products": [ "species_451862" ], "modifiers": [], "additional_components": [ "Q9VA38", "WTS", "Q45VV3", "yki" ] }, "reaction_390120": { "compartment": "compartment_70101", "id": "reaction_390120", "reactome": "R-DME-390120", "name": "Phosphorylated HPO dimer phosphorylates TH", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase phosphorylates Thread (TH) aka drosophila inhibitor of apoptosis protein 1 (Diap1) at unknown residues. This affects TH's stability.", "reactants": [ "species_113592", "species_390182" ], "products": [ "species_29370", "species_390103" ], "modifiers": [ [ "species_390068", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390059": { "compartment": "compartment_70101", "id": "reaction_390059", "reactome": "R-DME-390059", "name": "HPO dimer binds to RASSF", "reversible": "false", "notes": "Ras association family member (RASSF) associates with inactive Hippo (HPO) kinase homodimer through their shared SARAH (Salvador/Rassf/Hippo) domains. It should be noted that Hippo (HPO) kinase domain also associates with scaffolding protein Salvador (SAV) through SARAH domains. However, RASSF fails to bind to SAV. HPO associated with RASSF shows barely detectable levels of phosphorylation. In this complex, HPO homodimer remains unphosphorylated and inactive. Thus, RASSF restricts HPO activity by competing with SAV for binding to HPO homodimer.", "reactants": [ "species_390185", "species_390054" ], "products": [ "species_390177" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q9VCQ7", "RASSF", "Q8T0S6", "HPO" ] }, "reaction_10458089": { "compartment": "compartment_70101", "id": "reaction_10458089", "reactome": "R-DME-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458077" ], "products": [ "species_10458083" ], "modifiers": [], "additional_components": [ "FBgn0266411", "FBgn0266411" ] }, "reaction_10458148": { "compartment": "compartment_7660", "id": "reaction_10458148", "reactome": "R-DME-1234171", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458083", "species_10458122" ], "products": [ "species_10458124" ], "modifiers": [], "additional_components": [ "FBgn0266411", "FBgn0264075", "O15945", "FBgn0264075", "Q24167", "FBgn0266411" ] }, "reaction_10458130": { "compartment": "compartment_7660", "id": "reaction_10458130", "reactome": "R-DME-1234167", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447242", "species_29428", "species_10458124", "species_10458126" ], "products": [ "species_10458128" ], "modifiers": [], "additional_components": [ "FBgn0261617", "O15945", "FBgn0264075", "Q24167", "FBgn0266411", "FBgn0261617", "M9MS40", "FBgn0261617", "O15945", "FBgn0264075", "Q24167", "FBgn0266411" ] }, "reaction_10443099": { "compartment": "compartment_70101", "id": "reaction_10443099", "reactome": "R-DME-210977", "name": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10443096", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "Q5BIB8", "FBgn0087011", "Q4V4U2", "FBgn0050280", "P26675", "Sos" ] }, "reaction_10467110": { "compartment": "compartment_876", "id": "reaction_10467110", "reactome": "R-DME-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467106", "species_10467101" ], "products": [ "species_10467108" ], "modifiers": [], "additional_components": [ "FBgn0264561", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "M9PIG4", "FBgn0264561" ] }, "reaction_10464490": { "compartment": "compartment_876", "id": "reaction_10464490", "reactome": "R-DME-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10464487", "catalyst" ] ], "additional_components": [ "B7YZT5", "FBgn0286511" ] }, "reaction_10464470": { "compartment": "compartment_876", "id": "reaction_10464470", "reactome": "R-DME-2029468", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_29372", "species_112275" ], "modifiers": [ [ "species_10464465", "catalyst" ] ], "additional_components": [ "FBgn0037341" ] }, "reaction_10464499": { "compartment": "compartment_876", "id": "reaction_10464499", "reactome": "R-DME-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10467643": { "compartment": "compartment_7660", "id": "reaction_10467643", "reactome": "R-DME-3215385", "name": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467633" ], "products": [ "species_10467640" ], "modifiers": [ [ "species_10467633", "catalyst" ] ], "additional_components": [ "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10467720": { "compartment": "compartment_7660", "id": "reaction_10467720", "reactome": "R-DME-3215448", "name": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467716", "species_10467638" ], "products": [ "species_10467718" ], "modifiers": [], "additional_components": [ "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715" ] }, "reaction_10467650": { "compartment": "compartment_7660", "id": "reaction_10467650", "reactome": "R-DME-3215406", "name": "PRMT5 binds WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467624", "species_10467629" ], "products": [ "species_10467631" ], "modifiers": [ [ "species_10467648", "inhibitor" ] ], "additional_components": [ "FBgn0003978", "FBgn0015925", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "FBgn0015925" ] }, "reaction_10467501": { "compartment": "compartment_7660", "id": "reaction_10467501", "reactome": "R-DME-3132737", "name": "MAPKs phosphorylate ETS1 and ETS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467496" ], "products": [ "species_113582", "species_10467499" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "FBgn0003118", "FBgn0003118", "P40417", "FBgn0003256" ] }, "reaction_10476303": { "compartment": "compartment_7660", "id": "reaction_10476303", "reactome": "R-DME-5682020", "name": "MRN complex binds shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432372", "species_3785706" ], "products": [ "species_10476301" ], "modifiers": [], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10481055": { "compartment": "compartment_7660", "id": "reaction_10481055", "reactome": "R-DME-6792712", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10481052" ], "products": [ "species_2485002", "species_10476309" ], "modifiers": [ [ "species_10481052", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080" ] }, "reaction_10454382": { "compartment": "compartment_876", "id": "reaction_10454382", "reactome": "R-DME-888589", "name": "Release of GABA at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454363", "species_74016" ], "products": [ "species_10443025", "species_10454369", "species_10442983", "species_10442919", "species_352003", "species_10454379", "species_10443021", "species_10442973", "species_10454365", "species_10454367", "species_10443023" ], "modifiers": [ [ "species_10454363", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "M9PE32", "FBgn0264606", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0266599", "FBgn0264606", "FBgn0004574", "P20228", "FBgn0004516", "species_74016", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0033911", "FBgn0004179", "FBgn0004242", "Q8IPM8", "FBgn0041605", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "M9PE32", "FBgn0264606", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343" ] }, "reaction_10455094": { "compartment": "compartment_917758", "id": "reaction_10455094", "reactome": "R-DME-917744", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10442919", "species_10442983", "species_10442968", "species_10454361", "species_10442973" ], "products": [ "species_10454363" ], "modifiers": [ [ "species_10454361", "catalyst" ] ], "additional_components": [ "FBgn0013343", "FBgn0004574", "FBgn0264606", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "FBgn0041605", "Q8IPM8", "FBgn0041605", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "M9PE32", "FBgn0264606", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516" ] }, "reaction_10454328": { "compartment": "compartment_70101", "id": "reaction_10454328", "reactome": "R-DME-888572", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10454325", "catalyst" ] ], "additional_components": [ "P20228", "FBgn0004516" ] }, "reaction_10454340": { "compartment": "compartment_917757", "id": "reaction_10454340", "reactome": "R-DME-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10454337", "catalyst" ] ], "additional_components": [ "P20228", "FBgn0004516" ] }, "reaction_10454385": { "compartment": "compartment_70101", "id": "reaction_10454385", "reactome": "R-DME-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10454349", "catalyst" ] ], "additional_components": [ "FBgn0033911" ] }, "reaction_10465871": { "compartment": "compartment_70101", "id": "reaction_10465871", "reactome": "R-DME-2465919", "name": "AWAT2 transfers PALM to 11cROL forming 11cRPALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431863", "species_200993" ], "products": [ "species_10465860", "species_76194" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927", "CHEBI:16254", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10465892": { "compartment": "compartment_70101", "id": "reaction_10465892", "reactome": "R-DME-2465971", "name": "RLBP1 binds atROL to form RLBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431861", "species_2473617" ], "products": [ "species_10465890" ], "modifiers": [], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_2473604", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289" ] }, "reaction_10465888": { "compartment": "compartment_70101", "id": "reaction_10465888", "reactome": "R-DME-2465940", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_2473607" ], "modifiers": [ [ "species_10465885", "catalyst" ] ], "additional_components": [ "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043" ] }, "reaction_10484702": { "compartment": "compartment_984", "id": "reaction_10484702", "reactome": "R-DME-6799959", "name": "PGLYRP3,4 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10484698" ], "products": [ "species_10484700" ], "modifiers": [ [ "species_158417", "catalyst" ] ], "additional_components": [ "Q9VYX7", "FBgn0030310", "Q9VYX7", "FBgn0030310", "species_6789198" ] }, "reaction_10485860": { "compartment": "compartment_984", "id": "reaction_10485860", "reactome": "R-DME-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485854" ], "products": [ "species_10485858" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "CHEBI:62643", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273", "CHEBI:62643", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273" ] }, "reaction_10489510": { "compartment": "compartment_984", "id": "reaction_10489510", "reactome": "R-DME-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10482357", "species_6789198" ], "products": [ "species_10489508" ], "modifiers": [], "additional_components": [ "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "species_6789198", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539" ] }, "reaction_10489513": { "compartment": "compartment_984", "id": "reaction_10489513", "reactome": "R-DME-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10489508" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10489508", "catalyst" ] ], "additional_components": [ "species_6789198", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "species_1236719", "CHEBI:21615", "species_6789198", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539" ] }, "reaction_10486923": { "compartment": "compartment_984", "id": "reaction_10486923", "reactome": "R-DME-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10486917" ], "products": [ "species_10486921" ], "modifiers": [], "additional_components": [ "FBgn0039527", "Q9VB21", "FBgn0039527", "species_6803081" ] }, "reaction_10484723": { "compartment": "compartment_984", "id": "reaction_10484723", "reactome": "R-DME-6799981", "name": "PGLYRP2 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10484716" ], "products": [ "species_10484718" ], "modifiers": [], "additional_components": [ "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "species_6789198" ] }, "reaction_10484721": { "compartment": "compartment_984", "id": "reaction_10484721", "reactome": "R-DME-6799977", "name": "PGLYRP2 hydrolyzes bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10484718" ], "products": [ "species_6799970", "species_10484716", "species_6799975" ], "modifiers": [ [ "species_10484716", "catalyst" ], [ "species_158417", "catalyst" ] ], "additional_components": [ "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "species_6789198", "CHEBI:28881", "species_1678743", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576" ] }, "reaction_10489521": { "compartment": "compartment_984", "id": "reaction_10489521", "reactome": "R-DME-8862771", "name": "PLA2G2A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8931784", "species_10460239" ], "products": [ "species_10489519" ], "modifiers": [], "additional_components": [ "CHEBI:62643", "species_74016", "Q8IML0", "FBgn0039655", "species_74016", "Q8IML0", "FBgn0039655", "CHEBI:62643" ] }, "reaction_10480075": { "compartment": "compartment_1222282", "id": "reaction_10480075", "reactome": "R-DME-6789072", "name": "PGLYRP1 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10480071" ], "products": [ "species_10480073" ], "modifiers": [ [ "species_1562550", "catalyst" ] ], "additional_components": [ "C0HK98", "FBgn0043576", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "Q9VYX7", "FBgn0030310", "C0HK98", "FBgn0043576", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "Q9VYX7", "FBgn0030310", "species_6789198" ] }, "reaction_10485878": { "compartment": "compartment_984", "id": "reaction_10485878", "reactome": "R-DME-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485852", "species_8931784" ], "products": [ "species_10485854" ], "modifiers": [], "additional_components": [ "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273", "CHEBI:62643", "CHEBI:62643", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273" ] }, "reaction_10485882": { "compartment": "compartment_984", "id": "reaction_10485882", "reactome": "R-DME-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485852", "species_6789198" ], "products": [ "species_10485880" ], "modifiers": [], "additional_components": [ "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273", "species_6789198", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273" ] }, "reaction_10457859": { "compartment": "compartment_1222282", "id": "reaction_10457859", "reactome": "R-DME-1222491", "name": "Lactoferrin scavenges iron ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2101051", "species_1222611", "species_10457855" ], "products": [ "species_10457857" ], "modifiers": [], "additional_components": [ "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "species_1222611", "species_2101051" ] }, "reaction_10467566": { "compartment": "compartment_70101", "id": "reaction_10467566", "reactome": "R-DME-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10467562" ], "products": [ "species_10467564" ], "modifiers": [], "additional_components": [ "FBgn0020270", "Q9XYZ4", "FBgn0020270", "species_874088" ] }, "reaction_10467514": { "compartment": "compartment_70101", "id": "reaction_10467514", "reactome": "R-DME-3134914", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467512" ], "products": [ "species_10467510" ], "modifiers": [], "additional_components": [] }, "reaction_10458430": { "compartment": "compartment_70101", "id": "reaction_10458430", "reactome": "R-DME-1250264", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_10458426" ], "products": [ "species_10458428" ], "modifiers": [], "additional_components": [ "FBgn0040070", "Q9VGU4", "FBgn0037856", "A8JQV1", "FBgn0042105", "Q9I7L1", "FBgn0042104", "Q9VI53", "FBgn0037465", "Q9I7L0", "FBgn0042102", "Q9VI00", "FBgn0037518", "Q9I7K8", "FBgn0042103", "Q9VHZ9", "FBgn0037519", "Q9I7K7", "FBgn0042101", "Q9VHZ8", "FBgn0037520", "Q8SYU5", "FBgn0037517", "Q9VGU7", "FBgn0037853", "Q0E8K8", "FBgn0035103", "Q9VGU4", "FBgn0037856", "A8JQV1", "FBgn0042105", "Q9I7L1", "FBgn0042104", "Q9VI53", "FBgn0037465", "Q9I7L0", "FBgn0042102", "Q9VI00", "FBgn0037518", "Q9I7K8", "FBgn0042103", "Q9VHZ9", "FBgn0037519", "Q9I7K7", "FBgn0042101", "Q9VHZ8", "FBgn0037520", "Q8SYU5", "FBgn0037517", "Q9VGU7", "FBgn0037853", "Q0E8K8", "FBgn0035103", "Q9V429", "FBgn0040070" ] }, "reaction_10458432": { "compartment": "compartment_70101", "id": "reaction_10458432", "reactome": "R-DME-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_1250243" ], "products": [ "species_10430994" ], "modifiers": [], "additional_components": [ "FBgn0040070", "FBgn0040070" ] }, "reaction_10464323": { "compartment": "compartment_70101", "id": "reaction_10464323", "reactome": "R-DME-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10446525" ], "products": [ "species_29370", "species_10447061", "species_10446509" ], "modifiers": [ [ "species_10446511", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698" ] }, "reaction_10437523": { "compartment": "compartment_984", "id": "reaction_10437523", "reactome": "R-DME-168947", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_168948", "species_10437517" ], "products": [ "species_10437521" ], "modifiers": [], "additional_components": [ "FBgn0036978", "Q9VPH1", "FBgn0036978" ] }, "reaction_10485986": { "compartment": "compartment_984", "id": "reaction_10485986", "reactome": "R-DME-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485978", "species_166005" ], "products": [ "species_10485984" ], "modifiers": [], "additional_components": [ "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979", "species_6803081", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979" ] }, "reaction_10486230": { "compartment": "compartment_984", "id": "reaction_10486230", "reactome": "R-DME-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443916" ], "products": [ "species_10485978" ], "modifiers": [], "additional_components": [ "E1JIT5", "FBgn0038979", "Q9VCZ5", "FBgn0038978", "Q24537", "Dsp1", "Q05783", "FBgn0004362", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979" ] }, "reaction_10485982": { "compartment": "compartment_984", "id": "reaction_10485982", "reactome": "R-DME-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485978", "species_181015" ], "products": [ "species_10485980" ], "modifiers": [], "additional_components": [ "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979", "species_181015", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979" ] }, "reaction_10434118": { "compartment": "compartment_7660", "id": "reaction_10434118", "reactome": "R-DME-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433259", "species_10433230" ], "products": [ "species_10434112" ], "modifiers": [], "additional_components": [ "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554" ] }, "reaction_390141": { "compartment": "compartment_70101", "id": "reaction_390141", "reactome": "R-DME-390141", "name": "D inhibits WTS", "reversible": "false", "notes": "In the absence of the transmembrane cadherin Fat (FT), the unconventional myosin Dachs (D) accumulates at the plasma membrane where it has access to and inhibits Warts (WTS) kinase.", "reactants": [ "species_390026", "species_390037" ], "products": [ "species_451889", "species_390037" ], "modifiers": [], "additional_components": [ "FBgn0000411", "FBgn0000411" ] }, "reaction_10495859": { "compartment": "compartment_7660", "id": "reaction_10495859", "reactome": "R-DME-9007926", "name": "ATRX binds DAXX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495855", "species_10467725" ], "products": [ "species_10495857" ], "modifiers": [], "additional_components": [ "FBgn0026573", "FBgn0031820", "Q9VMD0", "FBgn0031820", "A1Z8R2", "FBgn0026573" ] }, "reaction_10435134": { "compartment": "compartment_984", "id": "reaction_10435134", "reactome": "R-DME-140769", "name": "factor VII -> factor VIIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435117" ], "products": [ "species_10435131" ], "modifiers": [ [ "species_10435079", "catalyst" ] ], "additional_components": [ "species_74016", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016" ] }, "reaction_350400": { "compartment": "compartment_70101", "id": "reaction_350400", "reactome": "R-DME-350400", "name": "PK binds to DSH", "reversible": "false", "notes": "The PET/LIM domain of Prickle (PK) interacts with DEP domain and C-terminus of Dishevelled (DSH). The DEP domain is required by DSH for membrane localisation. Binding of Diego (DGO) and PK to DSH is mutually exclusive. PK binding to DSH prevents FZ PCP signalling.", "reactants": [ "species_351050", "species_205749" ], "products": [ "species_351069" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "A1Z6W3", "PK" ] }, "reaction_350403": { "compartment": "compartment_70101", "id": "reaction_350403", "reactome": "R-DME-350403", "name": "DGO binds to PK", "reversible": "false", "notes": "In the cytosol, Diego (DGO) can bind to Prickle (PK). This may result in there being less DGO to bind to and stabilise the Frizzled (FZ):Dishevelled (DSH) complex.", "reactants": [ "species_351050", "species_351073" ], "products": [ "species_351093" ], "modifiers": [], "additional_components": [ "Q7JUF2", "DGO", "A1Z6W3", "PK" ] }, "reaction_10445880": { "compartment": "compartment_876", "id": "reaction_10445880", "reactome": "R-DME-380905", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445872", "species_10445808", "species_10442978", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10445874" ], "modifiers": [ [ "species_10445872", "catalyst" ] ], "additional_components": [ "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0013343", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964" ] }, "reaction_10445877": { "compartment": "compartment_984", "id": "reaction_10445877", "reactome": "R-DME-380901", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445874" ], "products": [ "species_10445808", "species_10443025", "species_114523", "species_10442919", "species_10444855", "species_10443003", "species_10443019", "species_10442973", "species_10443023" ], "modifiers": [ [ "species_10445874", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0005586", "FBgn0004574", "FBgn0260964", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964" ] }, "reaction_10445844": { "compartment": "compartment_374932", "id": "reaction_10445844", "reactome": "R-DME-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10444368", "catalyst" ] ], "additional_components": [ "FBgn0260964" ] }, "reaction_10445870": { "compartment": "compartment_984", "id": "reaction_10445870", "reactome": "R-DME-380869", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445810" ], "products": [ "species_10445808", "species_10443025", "species_380873", "species_10444855", "species_10442919", "species_10443003", "species_10443019", "species_10442973", "species_10443023" ], "modifiers": [ [ "species_10445810", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0260964", "FBgn0004574", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343" ] }, "reaction_10471622": { "compartment": "compartment_70101", "id": "reaction_10471622", "reactome": "R-DME-5336443", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445828", "species_10445833", "species_10445823" ], "products": [ "species_10445839" ], "modifiers": [], "additional_components": [ "FBgn0013759", "FBgn0039269", "X2JE74", "FBgn0026313", "Q9W2S5", "FBgn0052677", "X2JE74", "FBgn0026313", "Q9W2S5", "FBgn0052677", "Q8IMT8", "FBgn0039269", "Q24210", "FBgn0013759" ] }, "reaction_10445841": { "compartment": "compartment_70101", "id": "reaction_10445841", "reactome": "R-DME-380574", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445808", "species_10442978", "species_10445797", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10445810" ], "modifiers": [ [ "species_10445797", "catalyst" ], [ "species_10445839", "catalyst" ] ], "additional_components": [ "FBgn0013343", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "X2JE74", "FBgn0026313", "Q9W2S5", "FBgn0052677", "Q8IMT8", "FBgn0039269", "Q24210", "FBgn0013759" ] }, "reaction_10442917": { "compartment": "compartment_984", "id": "reaction_10442917", "reactome": "R-DME-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10442914", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "Q9VRE6", "FBgn0064123", "M9PD84", "FBgn0259822", "P91645", "FBgn0263111" ] }, "reaction_10453885": { "compartment": "compartment_984", "id": "reaction_10453885", "reactome": "R-DME-629596", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10453878", "species_372533" ], "products": [ "species_10453880" ], "modifiers": [], "additional_components": [ "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "P25162", "FBgn0004118", "P17644", "FBgn0000039", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "A0A0S0WNY8", "FBgn0266347", "Q9W3G6", "FBgn0015519", "A0A499GGQ3", "FBgn0028875", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "P25162", "FBgn0004118", "P17644", "FBgn0000039", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "A0A0S0WNY8", "FBgn0266347", "Q9W3G6", "FBgn0015519", "A0A499GGQ3", "FBgn0028875", "species_372533" ] }, "reaction_10453883": { "compartment": "compartment_70101", "id": "reaction_10453883", "reactome": "R-DME-629595", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10453880", "catalyst" ] ], "additional_components": [ "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "P25162", "FBgn0004118", "P17644", "FBgn0000039", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "A0A0S0WNY8", "FBgn0266347", "Q9W3G6", "FBgn0015519", "A0A499GGQ3", "FBgn0028875", "species_372533" ] }, "reaction_10453827": { "compartment": "compartment_984", "id": "reaction_10453827", "reactome": "R-DME-629588", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10453820", "species_372533" ], "products": [ "species_10453822" ], "modifiers": [], "additional_components": [ "P09478", "FBgn0000036", "P04755", "FBgn0000038", "P25162", "FBgn0004118", "Q9W3G6", "FBgn0015519", "A0A0S0WNY8", "FBgn0266347", "P17644", "FBgn0000039", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "species_372533", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "P25162", "FBgn0004118", "Q9W3G6", "FBgn0015519", "A0A0S0WNY8", "FBgn0266347", "P17644", "FBgn0000039", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261" ] }, "reaction_10453825": { "compartment": "compartment_876", "id": "reaction_10453825", "reactome": "R-DME-622325", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10453822", "catalyst" ] ], "additional_components": [ "species_372533", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "P25162", "FBgn0004118", "Q9W3G6", "FBgn0015519", "A0A0S0WNY8", "FBgn0266347", "P17644", "FBgn0000039", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261" ] }, "reaction_10455728": { "compartment": "compartment_876", "id": "reaction_10455728", "reactome": "R-DME-975389", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10455725", "catalyst" ] ], "additional_components": [ "Q9W4G1", "FBgn0029733", "Q9VVH4", "FBgn0036727", "Q9V9Y4", "FBgn0039840", "Q94900", "FBgn0024963", "M9PI70", "FBgn0264908", "species_29424" ] }, "reaction_350444": { "compartment": "compartment_70101", "id": "reaction_350444", "reactome": "R-DME-350444", "name": "ROK phosphorylates SQH", "reversible": "false", "notes": "Myosin regulatory light chain (MRLC) orthologue Spaghetti Squash (SQH) is phosphorylated at Thr20 and Ser21 by Rho-kinase (ROK). Zipper (ZIP) the myosin heavy chain orthologue would be expected to have its conformation modified and catalytic ativity elevated upon SQH phosphorylation. This leads to cytoskeletal organisation and correct pre-hair orientation.", "reactants": [ "species_113592", "species_351068" ], "products": [ "species_351002", "species_29370" ], "modifiers": [ [ "species_450785", "catalyst" ] ], "additional_components": [ "Q99323", "zip", "P40423", "phospho-sqh", "P54357", "Mlc-c", "Q99323", "zip", "P54357", "Mlc-c", "P40423", "phospho-sqh", "Q9U779", "ROK", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_350362": { "compartment": "compartment_70101", "id": "reaction_350362", "reactome": "R-DME-350362", "name": "ROK phosphorylates MBS", "reversible": "false", "notes": "Myosin binding subunit (MBS) of Myosin phosphatase is phosphorylated at Thr594 by activated Rho-kinase (ROK). Myosin phosphatase is subsequently deactivated.", "reactants": [ "species_351071", "species_113592" ], "products": [ "species_29370", "species_351077" ], "modifiers": [ [ "species_450785", "catalyst" ] ], "additional_components": [ "P48462", "flw", "P12982", "PP1-87B", "Q8IQN4", "Phospho MBS", "P48462", "flw", "P12982", "PP1-87B", "Q8IQN4", "Phospho MBS", "Q9U779", "ROK", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_10455221": { "compartment": "compartment_70101", "id": "reaction_10455221", "reactome": "R-DME-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455216", "species_113592" ], "products": [ "species_10455218", "species_29370" ], "modifiers": [ [ "species_10455216", "catalyst" ] ], "additional_components": [ "O46080", "FBgn0023520", "Q9VKQ6", "FBgn0032296", "Q9VYS3", "FBgn0030354", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "O46080", "FBgn0023520", "Q9VKQ6", "FBgn0032296", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VYS3", "FBgn0030354", "O46080", "FBgn0023520", "Q9VKQ6", "FBgn0032296", "Q9VYS3", "FBgn0030354", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10455200": { "compartment": "compartment_70101", "id": "reaction_10455200", "reactome": "R-DME-927836", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455197" ], "products": [ "species_10455182" ], "modifiers": [ [ "species_10455197", "catalyst" ] ], "additional_components": [ "Q9V414", "FBgn0019890", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VYS3", "FBgn0030354", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q9VBZ6", "FBgn0039260", "P21187", "FBgn0265297", "Q9V414", "FBgn0019890", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q9VYS3", "FBgn0030354", "Q9VBZ6", "FBgn0039260", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9V414", "FBgn0019890", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VYS3", "FBgn0030354", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q9VBZ6", "FBgn0039260" ] }, "reaction_10455156": { "compartment": "compartment_70101", "id": "reaction_10455156", "reactome": "R-DME-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455152", "species_10455132" ], "products": [ "species_10455154" ], "modifiers": [], "additional_components": [ "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VK85", "FBgn0020443", "species_29420", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "FBgn0030354", "Q9VYS3", "FBgn0030354", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VK85", "FBgn0020443", "species_29420", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974" ] }, "reaction_10429278": { "compartment": "compartment_7660", "id": "reaction_10429278", "reactome": "R-DME-72095", "name": "Internal Methylation of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429250" ], "products": [ "species_10429258" ], "modifiers": [ [ "species_10429275", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCE6", "FBgn0039139", "Q9Y091", "FBgn0000662", "Q9VLP7", "FBgn0032016" ] }, "reaction_10432074": { "compartment": "compartment_7660", "id": "reaction_10432074", "reactome": "R-DME-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432068" ], "products": [ "species_10432068" ], "modifiers": [], "additional_components": [ "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587" ] }, "reaction_10432072": { "compartment": "compartment_7660", "id": "reaction_10432072", "reactome": "R-DME-75081", "name": "Formation of AT-AC B Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432064", "species_10432054" ], "products": [ "species_10432066" ], "modifiers": [], "additional_components": [ "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786" ] }, "reaction_10432070": { "compartment": "compartment_7660", "id": "reaction_10432070", "reactome": "R-DME-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432066" ], "products": [ "species_10432068", "species_10432058" ], "modifiers": [], "additional_components": [ "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426" ] }, "reaction_10449034": { "compartment": "compartment_70101", "id": "reaction_10449034", "reactome": "R-DME-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448979", "species_429974" ], "products": [ "species_10448981" ], "modifiers": [], "additional_components": [ "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067", "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067" ] }, "reaction_10449015": { "compartment": "compartment_70101", "id": "reaction_10449015", "reactome": "R-DME-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10448981" ], "products": [ "species_10448983", "species_430004" ], "modifiers": [ [ "species_10449012", "catalyst" ] ], "additional_components": [ "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067", "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067", "Q9VKK1", "FBgn0283682", "Q9VVI2", "FBgn0036735", "Q5U127", "FBgn0036534", "Q9W1H5", "FBgn0034921", "P23128", "FBgn0004419" ] }, "reaction_10470317": { "compartment": "compartment_7660", "id": "reaction_10470317", "reactome": "R-DME-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10468620" ], "products": [ "species_113582", "species_10470281" ], "modifiers": [ [ "species_10470314", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "P22813", "FBgn0001222", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691" ] }, "reaction_10470283": { "compartment": "compartment_7660", "id": "reaction_10470283", "reactome": "R-DME-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470233" ], "products": [ "species_10470271" ], "modifiers": [ [ "species_10470276", "catalyst" ], [ "species_10470281", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "P02517", "FBgn0001225", "P22979", "FBgn0001229", "P02516", "FBgn0001224", "P05812", "FBgn0001227", "P02515", "FBgn0001223", "P02518", "FBgn0001226", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "P02828", "FBgn0001233", "Q9VK90", "FBgn0032429", "P11147", "FBgn0266599", "P22813", "FBgn0001222", "P22813", "FBgn0001222" ] }, "reaction_10470298": { "compartment": "compartment_7660", "id": "reaction_10470298", "reactome": "R-DME-5082387", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10468620" ], "products": [ "species_113582", "species_10470276" ], "modifiers": [ [ "species_10470295", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "P22813", "FBgn0001222", "Q00168", "FBgn0264607" ] }, "reaction_10468622": { "compartment": "compartment_70101", "id": "reaction_10468622", "reactome": "R-DME-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468616" ], "products": [ "species_10468620" ], "modifiers": [ [ "species_10432016", "inhibitor" ] ], "additional_components": [ "P22813", "FBgn0001222", "P22813", "FBgn0001222", "P92177", "14-3-3epsilon" ] }, "reaction_10470302": { "compartment": "compartment_7660", "id": "reaction_10470302", "reactome": "R-DME-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470300" ], "products": [ "species_10468620" ], "modifiers": [], "additional_components": [ "FBgn0001222", "P22813", "FBgn0001222" ] }, "reaction_10468653": { "compartment": "compartment_70101", "id": "reaction_10468653", "reactome": "R-DME-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468527" ], "products": [ "species_10468616" ], "modifiers": [ [ "species_10435578", "catalyst" ] ], "additional_components": [ "FBgn0001222", "P22813", "FBgn0001222", "P08736", "FBgn0284245", "P05303", "FBgn0000557" ] }, "reaction_10470329": { "compartment": "compartment_7660", "id": "reaction_10470329", "reactome": "R-DME-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470327" ], "products": [ "species_10470325", "species_10470300", "species_10470319" ], "modifiers": [], "additional_components": [ "Q9VH95", "FBgn0037728", "P22813", "FBgn0001222", "P02828", "FBgn0001233", "P02828", "FBgn0001233", "FBgn0001222", "FBgn0037728" ] }, "reaction_10468645": { "compartment": "compartment_70101", "id": "reaction_10468645", "reactome": "R-DME-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468643" ], "products": [ "species_10443622", "species_10468604", "species_10468527" ], "modifiers": [], "additional_components": [ "P22813", "FBgn0001222", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "FBgn0037728", "P02828", "FBgn0001233", "FBgn0001222" ] }, "reaction_10471524": { "compartment": "compartment_70101", "id": "reaction_10471524", "reactome": "R-DME-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10471519" ], "products": [ "species_10471521", "species_10443622", "species_10468604", "species_10468527" ], "modifiers": [ [ "species_10471519", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "Q7KN62", "FBgn0286784", "P02828", "FBgn0001233", "M9PJN5", "FBgn0026428", "Q9VH95", "FBgn0037728", "Q7KN62", "FBgn0286784", "M9PJN5", "FBgn0026428", "FBgn0037728", "P02828", "FBgn0001233", "FBgn0001222", "P22813", "FBgn0001222", "Q7KN62", "FBgn0286784", "P02828", "FBgn0001233", "M9PJN5", "FBgn0026428", "Q9VH95", "FBgn0037728" ] }, "reaction_350441": { "compartment": "compartment_70101", "id": "reaction_350441", "reactome": "R-DME-350441", "name": "FLW:MYPT-75D complex dephosphorylates SQH", "reversible": "false", "notes": "Flap wing (FLW) complexed with MYPT-75D dephosphorylates Spaghetti Squash (SQH).", "reactants": [ "species_351064" ], "products": [ "species_29372", "species_351041" ], "modifiers": [ [ "species_351025", "catalyst" ] ], "additional_components": [ "Q8SY34", "MYPT-75D", "P48462", "flw" ] }, "reaction_350475": { "compartment": "compartment_70101", "id": "reaction_350475", "reactome": "R-DME-350475", "name": "FLW:MBS complex dephosphorylates SQH", "reversible": "false", "notes": "Flap wing (FLW) complexed with Myosin binding subunit (MBS) dephosphorylates Spaghetti Squash (SQH).", "reactants": [ "species_351064" ], "products": [ "species_29372", "species_351041" ], "modifiers": [ [ "species_350944", "catalyst" ] ], "additional_components": [ "Q8IQN4", "Phospho MBS", "P48462", "flw" ] }, "reaction_350443": { "compartment": "compartment_70101", "id": "reaction_350443", "reactome": "R-DME-350443", "name": "PP1-87B:MBS complex dephosphorylates SQH", "reversible": "false", "notes": "PP1-87B complexed with Myosin binding subunit (MBS) dephosphorylates Spaghetti Squash (SQH).", "reactants": [ "species_351064" ], "products": [ "species_29372", "species_351041" ], "modifiers": [ [ "species_350963", "catalyst" ] ], "additional_components": [ "Q8IQN4", "Phospho MBS", "P12982", "PP1-87B" ] }, "reaction_450741": { "compartment": "compartment_876", "id": "reaction_450741", "reactome": "R-DME-450741", "name": "VANG, IN, FY, and FRTZ colocalise at the plasma membrane", "reversible": "false", "notes": "In the wing, Van Gogh (VANG) aka Strabismus (Stbm), Inturned (IN), Fuzzy (FY), and Fritz (FRTZ) all colocalise to the proximal side of the plasma membrane.", "reactants": [ "species_450782", "species_450734", "species_450722", "species_450756" ], "products": [ "species_450782", "species_450734", "species_450722", "species_450756" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK" ] }, "reaction_450770": { "compartment": "compartment_70101", "id": "reaction_450770", "reactome": "R-DME-450770", "name": "MWH binds to RHO1:GTP and is activated", "reversible": "false", "notes": "In the wing, autoinhibited multiple wing hairs (MWH) protein via its GTPase binding domain (GBD) binds to activated RHO1:GTP at the proximal side of the plasma membrane. This relieves the inhibition in MWH and it is now activated. The previously blocked dimerisation domain (DD) is now exposed and able to bind to other formins in a dominant negative manner. The sequestered formins are now unable to promote actin polymerisation around the proximal edge of the cell. It is postulated that the MWH:formin complexes which form in proximity to the developing hair at the distal edge inhibit formation of secondary hairs. There is evidence in the literature that MWH is also phosphorylated by an unknown kinase but definitive proof that this is important for its activity is currently undetermined (Strutt and Warrington, 2008).", "reactants": [ "species_350950", "species_450759" ], "products": [ "species_450755" ], "modifiers": [], "additional_components": [ "species_29438", "P48148", "Rho1", "Q9W0J2", "MWH", "species_29438", "P48148", "Rho1" ] }, "reaction_450802": { "compartment": "compartment_876", "id": "reaction_450802", "reactome": "R-DME-450802", "name": "FZ and VANG bind to STAN homodimer", "reversible": "false", "notes": "The seven-pass transmembrane protein Frizzled (FZ) and the four-pass transmembrane protein Van Gogh (VANG) aka Strabismus (Stbm) bind to opposite ends of the seven-pass transmembrane atypical cadherin Starry Night (STAN) aka Flamingo homodimer. In the case of VANG, this interaction is to the C-terminal domain of STAN. Additionally, there's a possibility of a direct interaction between FZ and VANG.", "reactants": [ "species_205850", "species_351026", "species_351126" ], "products": [ "species_450698" ], "modifiers": [], "additional_components": [ "Q9V5N8", "STAN", "O45030", "VANG", "Q9V5N8", "STAN", "P18537", "FZ" ] }, "reaction_350467": { "compartment": "compartment_70101", "id": "reaction_350467", "reactome": "R-DME-350467", "name": "GUG binds to FT", "reversible": "false", "notes": "The transcriptional repressor Grunge (GUG) aka Atro binds to the intracellular domain of Fat (FT) reinforcing the corresponding strong genetic interaction evidence. GUG like FT is specifically required in the R3 photoreceptor.", "reactants": [ "species_350975", "species_350966" ], "products": [ "species_350926" ], "modifiers": [], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS", "P33450", "Phospho FT", "Q24292", "DS", "Q9NHX6", "GUG" ] }, "reaction_350377": { "compartment": "compartment_876", "id": "reaction_350377", "reactome": "R-DME-350377", "name": "Extracellular domains of STAN bind to each other in adjacent cells", "reversible": "false", "notes": "The seven-pass transmembrane atypical cadherin Starry Night (STAN) aka Flamingo is known to mediate homophilic protein-protein interaction.", "reactants": [ "species_350928" ], "products": [ "species_351026" ], "modifiers": [], "additional_components": [ "Q9V5N8", "STAN" ] }, "reaction_10441901": { "compartment": "compartment_876", "id": "reaction_10441901", "reactome": "R-DME-202222", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441891", "species_113592" ], "products": [ "species_29370", "species_10441898" ], "modifiers": [ [ "species_10441882", "catalyst" ] ], "additional_components": [ "species_112275", "P83099", "FBgn0259680", "species_112275", "P83099", "FBgn0259680", "species_202247", "species_179838", "Q9W0V1", "Pdk1" ] }, "reaction_10441919": { "compartment": "compartment_70101", "id": "reaction_10441919", "reactome": "R-DME-202354", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441912", "species_179856" ], "products": [ "species_10441917" ], "modifiers": [], "additional_components": [ "FBgn0003416", "species_179856", "Q9VXH3", "FBgn0003416" ] }, "reaction_10441932": { "compartment": "compartment_70101", "id": "reaction_10441932", "reactome": "R-DME-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10441929", "catalyst" ] ], "additional_components": [ "FBgn0003416" ] }, "reaction_10447468": { "compartment": "compartment_70101", "id": "reaction_10447468", "reactome": "R-DME-418158", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447466" ], "products": [ "species_10447466" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733" ] }, "reaction_10447489": { "compartment": "compartment_70101", "id": "reaction_10447489", "reactome": "R-DME-418200", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447487" ], "products": [ "species_10447487" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P00528", "FBgn0262733" ] }, "reaction_10447473": { "compartment": "compartment_70101", "id": "reaction_10447473", "reactome": "R-DME-418163", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447466" ], "products": [ "species_10447470" ], "modifiers": [ [ "species_10447466", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733" ] }, "reaction_10449789": { "compartment": "compartment_70101", "id": "reaction_10449789", "reactome": "R-DME-442314", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449781" ], "products": [ "species_29420", "species_10449783" ], "modifiers": [ [ "species_10449786", "catalyst" ] ], "additional_components": [ "species_29420", "P40792", "RAC1_DROME", "P48148", "Rho1", "P40792", "RAC1_DROME", "P48148", "Rho1", "species_29438", "FBgn0040068" ] }, "reaction_10435017": { "compartment": "compartment_70101", "id": "reaction_10435017", "reactome": "R-DME-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10435014", "catalyst" ] ], "additional_components": [ "FBgn0003416" ] }, "reaction_10449704": { "compartment": "compartment_70101", "id": "reaction_10449704", "reactome": "R-DME-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10431820", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10448868": { "compartment": "compartment_876", "id": "reaction_10448868", "reactome": "R-DME-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448866" ], "products": [ "species_10435014" ], "modifiers": [], "additional_components": [ "FBgn0003416", "FBgn0003416" ] }, "reaction_10449763": { "compartment": "compartment_70101", "id": "reaction_10449763", "reactome": "R-DME-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449751" ], "products": [ "species_29420", "species_10449753" ], "modifiers": [ [ "species_10449756", "catalyst" ], [ "species_10449761", "catalyst" ], [ "species_10449759", "inhibitor" ] ], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29420", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "FBgn0040068", "Q9NHV9", "FBgn0040068", "species_179838", "species_179856", "Q9NHV9", "FBgn0040068" ] }, "reaction_10449777": { "compartment": "compartment_70101", "id": "reaction_10449777", "reactome": "R-DME-442291", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449769" ], "products": [ "species_29420", "species_10449771" ], "modifiers": [ [ "species_10449774", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "FBgn0040068" ] }, "reaction_10446140": { "compartment": "compartment_876", "id": "reaction_10446140", "reactome": "R-DME-381750", "name": "Olfactory Receptor - G Protein olfactory trimer complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446099", "species_10446067" ], "products": [ "species_10446101" ], "modifiers": [ [ "species_10446138", "catalyst" ] ], "additional_components": [ "Q4LBB9", "FBgn0038063", "P41596", "FBgn0011582", "Q9NFZ3", "FBgn0267252", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "P26308", "FBgn0001105", "Q4LBB9", "FBgn0038063", "P41596", "FBgn0011582", "Q9NFZ3", "FBgn0267252", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "P26308", "FBgn0001105", "Q9W1J5", "FBgn0034907" ] }, "reaction_10446069": { "compartment": "compartment_876", "id": "reaction_10446069", "reactome": "R-DME-381749", "name": "G Protein trimer formation (olfactory)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437306", "species_10437738", "species_10434556" ], "products": [ "species_10446067" ], "modifiers": [], "additional_components": [ "FBgn0001105", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "FBgn0267252", "Q9NFZ3", "FBgn0267252", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "P26308", "FBgn0001105" ] }, "reaction_10465838": { "compartment": "compartment_70101", "id": "reaction_10465838", "reactome": "R-DME-2453833", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2864099" ], "products": [ "species_30927", "species_2864103", "species_70106" ], "modifiers": [ [ "species_10465830", "catalyst" ], [ "species_10465836", "catalyst" ] ], "additional_components": [ "CHEBI:70762", "species_2534407", "CHEBI:70760", "CHEBI:70761", "CHEBI:16196", "CHEBI:17351", "species_3632881", "species_8934421", "FBgn0002937", "FBgn0000317" ] }, "reaction_10465854": { "compartment": "compartment_70101", "id": "reaction_10465854", "reactome": "R-DME-2454264", "name": "11cROL binds to RLBP1 to form RLBP1:11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30927", "species_10431861" ], "products": [ "species_10431863" ], "modifiers": [], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927" ] }, "reaction_10431900": { "compartment": "compartment_12045", "id": "reaction_10431900", "reactome": "R-DME-74872", "name": "RDH10,11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431863", "species_29366" ], "products": [ "species_70106", "species_10431865", "species_29364" ], "modifiers": [ [ "species_10431897", "catalyst" ] ], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927", "species_8960974", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q9VCR9", "FBgn0039043", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9W3K9", "FBgn0029994", "Q9VCS2", "FBgn0039040", "Q9VR28", "FBgn0031630" ] }, "reaction_10465852": { "compartment": "compartment_12045", "id": "reaction_10465852", "reactome": "R-DME-2454081", "name": "RDH5 oxidises 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431863", "species_29360" ], "products": [ "species_70106", "species_10431865", "species_73473" ], "modifiers": [ [ "species_10465841", "catalyst" ] ], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927", "species_8960974", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "FBgn0000056" ] }, "reaction_10495347": { "compartment": "compartment_70101", "id": "reaction_10495347", "reactome": "R-DME-8960973", "name": "RLBP1:11cRAL dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431865" ], "products": [ "species_10431861", "species_8960974" ], "modifiers": [], "additional_components": [ "species_8960974", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289" ] }, "reaction_10431849": { "compartment": "compartment_70101", "id": "reaction_10431849", "reactome": "R-DME-74843", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431845", "species_2473604" ], "products": [ "species_10431847" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_2473604", "Q8INK3", "FBgn0037913" ] } }, "collapsed_reaction_dictionary": { "reaction_10497653": { "compartment": "compartment_70101", "id": "reaction_10497653", "reactome": "R-DME-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10497649" ], "products": [ "species_10497651" ], "modifiers": [], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "FBgn0016126", "Q7JMV3", "FBgn0016126", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10435736": { "compartment": "compartment_70101", "id": "reaction_10435736", "reactome": "R-DME-159050", "name": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435730", "species_10430485" ], "products": [ "species_10432289", "species_10435734", "species_10432313" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "Q9VAN6", "FBgn0041186", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "FBgn0003321", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VAN6", "FBgn0041186", "FBgn0010774", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10433271": { "compartment": "compartment_7660", "id": "reaction_10433271", "reactome": "R-DME-77587", "name": "Docking of Mature Replication Dependent Histone mRNA with the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433265", "species_10429500", "species_10432253" ], "products": [ "species_10433269", "species_10429162", "species_10429167" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "FBgn0010774", "FBgn0003321", "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9VAN6", "FBgn0041186", "FBgn0022943", "FBgn0022942", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435732": { "compartment": "compartment_13231", "id": "reaction_10435732", "reactome": "R-DME-159046", "name": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433269" ], "products": [ "species_10435730" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9VAN6", "FBgn0041186", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "Q9VAN6", "FBgn0041186", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10470941": { "compartment": "compartment_876", "id": "reaction_10470941", "reactome": "R-DME-5218806", "name": "FYN autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470936" ], "products": [ "species_29370", "species_10470938" ], "modifiers": [ [ "species_10470936", "catalyst" ] ], "additional_components": [ "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "P00528", "FBgn0262733" ] }, "reaction_10471003": { "compartment": "compartment_876", "id": "reaction_10471003", "reactome": "R-DME-5218850", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10470998" ], "products": [ "species_29420", "species_10471000" ], "modifiers": [ [ "species_10470998", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29420", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29420" ] }, "reaction_10470975": { "compartment": "compartment_876", "id": "reaction_10470975", "reactome": "R-DME-5218821", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470972" ], "products": [ "species_29370", "species_10470910" ], "modifiers": [ [ "species_10433702", "catalyst" ] ], "additional_components": [ "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854", "P83099", "FBgn0259680", "A1Z9X0", "FBgn0261854", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091" ] }, "reaction_10470954": { "compartment": "compartment_70101", "id": "reaction_10470954", "reactome": "R-DME-5218813", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470931", "species_112275", "species_74016" ], "products": [ "species_10470952" ], "modifiers": [], "additional_components": [ "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854", "species_74016", "species_112275", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854" ] }, "reaction_10470934": { "compartment": "compartment_70101", "id": "reaction_10470934", "reactome": "R-DME-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470910" ], "products": [ "species_10470931", "species_29370" ], "modifiers": [ [ "species_10470910", "catalyst" ] ], "additional_components": [ "A1Z9X0", "FBgn0261854", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854", "A1Z9X0", "FBgn0261854", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091" ] }, "reaction_10470981": { "compartment": "compartment_876", "id": "reaction_10470981", "reactome": "R-DME-5218823", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446693", "species_113592" ], "products": [ "species_10470978", "species_29370" ], "modifiers": [ [ "species_10470952", "catalyst" ] ], "additional_components": [ "FBgn0030300", "FBgn0030300", "species_74016", "species_112275", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854" ] }, "reaction_10470994": { "compartment": "compartment_70101", "id": "reaction_10470994", "reactome": "R-DME-5218845", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470991" ], "products": [ "species_5218688", "species_10437909", "species_29370", "species_10439352" ], "modifiers": [ [ "species_10470978", "catalyst" ] ], "additional_components": [ "Q8IR23", "FBgn0003969", "species_1606609", "species_29438", "P08646", "RAS85D", "species_29438", "P08646", "RAS85D", "FBgn0003969", "FBgn0030300" ] }, "reaction_10441855": { "compartment": "compartment_70101", "id": "reaction_10441855", "reactome": "R-DME-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441844", "species_113592" ], "products": [ "species_29370", "species_10441853" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "species_74016", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10440781": { "compartment": "compartment_70101", "id": "reaction_10440781", "reactome": "R-DME-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440773", "species_113592" ], "products": [ "species_29370", "species_10440775", "species_10433704" ], "modifiers": [ [ "species_10440773", "catalyst" ] ], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838", "Q8INB9", "phospho-Akt1", "Q9W0V1", "Pdk1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "Q8INB9", "phospho-Akt1" ] }, "reaction_10471692": { "compartment": "compartment_876", "id": "reaction_10471692", "reactome": "R-DME-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471687" ], "products": [ "species_10447061", "species_29370", "species_10471000" ], "modifiers": [ [ "species_10446523", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10465531": { "compartment": "compartment_876", "id": "reaction_10465531", "reactome": "R-DME-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440771", "species_10433704" ], "products": [ "species_10440773" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "Q8INB9", "phospho-Akt1" ] }, "reaction_10471689": { "compartment": "compartment_876", "id": "reaction_10471689", "reactome": "R-DME-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471685" ], "products": [ "species_10471687" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10471703": { "compartment": "compartment_876", "id": "reaction_10471703", "reactome": "R-DME-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471000", "species_10446523" ], "products": [ "species_10471685" ], "modifiers": [], "additional_components": [ "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10471701": { "compartment": "compartment_876", "id": "reaction_10471701", "reactome": "R-DME-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471694" ], "products": [ "species_10471699", "species_29370" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q9VJB6", "FBgn0262018", "Q7PLI0", "FBgn0260799", "P18824", "arm", "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q7PLI0", "FBgn0260799", "Q9VJB6", "FBgn0262018", "P18824", "arm", "FBgn0267698" ] }, "reaction_10441860": { "compartment": "compartment_70101", "id": "reaction_10441860", "reactome": "R-DME-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10441857", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10465459": { "compartment": "compartment_70101", "id": "reaction_10465459", "reactome": "R-DME-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10441880" ], "products": [ "species_10433704" ], "modifiers": [], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10459875": { "compartment": "compartment_70101", "id": "reaction_10459875", "reactome": "R-DME-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10441853" ], "products": [ "species_10441857" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10440881": { "compartment": "compartment_70101", "id": "reaction_10440881", "reactome": "R-DME-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440860" ], "products": [ "species_10440771", "species_29370" ], "modifiers": [ [ "species_10440874", "catalyst" ], [ "species_10440879", "inhibitor" ] ], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "Q8INB9", "phospho-Akt1", "species_179838", "Q9VK45", "FBgn0021796", "Q9V719", "FBgn0033935", "Q9W328", "FBgn0264691", "Q9VWJ6", "FBgn0031006", "Q9V3Z1", "FBgn0028978", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10441872": { "compartment": "compartment_70101", "id": "reaction_10441872", "reactome": "R-DME-202137", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441840", "species_10440775" ], "products": [ "species_10441844" ], "modifiers": [], "additional_components": [ "P02828", "FBgn0001233", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "species_74016", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "species_74016" ] }, "reaction_10470966": { "compartment": "compartment_876", "id": "reaction_10470966", "reactome": "R-DME-5218819", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10470963", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10493673": { "compartment": "compartment_876", "id": "reaction_10493673", "reactome": "R-DME-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464321", "species_10470968" ], "products": [ "species_10470998" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "Q9NHV9", "FBgn0040068", "species_179838", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29420" ] }, "reaction_10470996": { "compartment": "compartment_876", "id": "reaction_10470996", "reactome": "R-DME-5218847", "name": "PAK2 binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470880", "species_10446517" ], "products": [ "species_10470985" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10470961": { "compartment": "compartment_876", "id": "reaction_10470961", "reactome": "R-DME-5218814", "name": "PAK2 autophorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470958" ], "products": [ "species_10470947", "species_29370" ], "modifiers": [ [ "species_10470958", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10439437": { "compartment": "compartment_70101", "id": "reaction_10439437", "reactome": "R-DME-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439409", "species_113592" ], "products": [ "species_29370", "species_10439416" ], "modifiers": [ [ "species_10439434", "catalyst" ] ], "additional_components": [ "FBgn0013987", "FBgn0013987", "species_29926", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765" ] }, "reaction_10471021": { "compartment": "compartment_70101", "id": "reaction_10471021", "reactome": "R-DME-5218916", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471014" ], "products": [ "species_10449184", "species_29370", "species_10471019" ], "modifiers": [ [ "species_10439416", "catalyst" ] ], "additional_components": [ "Q8IQW5", "FBgn0031037", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "FBgn0031037", "FBgn0013987" ] }, "reaction_10470892": { "compartment": "compartment_70101", "id": "reaction_10470892", "reactome": "R-DME-5218804", "name": "p38 MAPK activation by VEGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451571", "species_113592" ], "products": [ "species_29370", "species_10439434" ], "modifiers": [ [ "species_10470889", "catalyst" ] ], "additional_components": [ "species_29926", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "species_29926", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10470987": { "compartment": "compartment_876", "id": "reaction_10470987", "reactome": "R-DME-5218832", "name": "CDC42:GTP binds PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439139", "species_10470985" ], "products": [ "species_10470958" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "B7Z0W0", "FBgn0267698", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10469449": { "compartment": "compartment_876", "id": "reaction_10469449", "reactome": "R-DME-3928647", "name": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604", "species_10434906" ], "products": [ "species_10447647" ], "modifiers": [], "additional_components": [ "FBgn0026181", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181" ] }, "reaction_10464390": { "compartment": "compartment_876", "id": "reaction_10464390", "reactome": "R-DME-2029465", "name": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067", "species_10464386", "species_10464339", "species_179838" ], "products": [ "species_10464388" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "FBgn0052082", "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10470950": { "compartment": "compartment_876", "id": "reaction_10470950", "reactome": "R-DME-5218812", "name": "FYN phosphorylates PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470947", "species_113592" ], "products": [ "species_29370", "species_10470889" ], "modifiers": [ [ "species_10470947", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10471107": { "compartment": "compartment_70101", "id": "reaction_10471107", "reactome": "R-DME-5228992", "name": "ROCK1,ROCK2 are activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447647" ], "products": [ "species_10471105" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181", "species_29926", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181" ] }, "reaction_10471008": { "compartment": "compartment_70101", "id": "reaction_10471008", "reactome": "R-DME-5218854", "name": "p-Y420-FYN is phosphorylated on S21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470938" ], "products": [ "species_10470880", "species_29370" ], "modifiers": [ [ "species_10471005", "catalyst" ] ], "additional_components": [ "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_209235": { "compartment": "compartment_13231", "id": "reaction_209235", "reactome": "R-DME-209235", "name": "Phosphorylated BSK kinase transports from the cytosol to the nucleus", "reversible": "false", "notes": "Free phosphorylated Basket (BSK) kinase is now able to translocate from the cytosol to the nucleus.", "reactants": [ "species_206213" ], "products": [ "species_206300" ], "modifiers": [], "additional_components": [] }, "reaction_209330": { "compartment": "compartment_7660", "id": "reaction_209330", "reactome": "R-DME-209330", "name": "Phosphorylated BSK kinase and the AP-1 transcription factor, JRA:KAY, bind to CKA scaffolding protein in the nucleus", "reversible": "false", "notes": "In the nucleus, another molecule of the scaffolding protein CKA binds the phosphorylated Basket (BSK) kinase and the AP-1 transcription factor heterodimer. The latter is made up of the c-Jun ortholgue, Jun-related antigen (JRA) and the c-Fos orthologue, Kayak (KAY).", "reactants": [ "species_206300", "species_205983", "species_206724" ], "products": [ "species_207020" ], "modifiers": [], "additional_components": [ "P21525", "phospho-kay", "P18289", "phospho-Jra", "P21525", "phospho-kay", "P18289", "phospho-Jra", "Q9VLT9", "CKA", "P92208", "bsk" ] }, "reaction_209381": { "compartment": "compartment_7660", "id": "reaction_209381", "reactome": "R-DME-209381", "name": "AP-1 transcription factor, JRA:KAY, is phosphorylated by phosphorylated BSK kinase", "reversible": "false", "notes": "Phosphorylated Basket (BSK) kinase phosphorylates residues Ser82 and Ser92 on JRA along with residues Thr216 and Thr220 on KAY.", "reactants": [ "species_207020", "species_29358" ], "products": [ "species_113582", "species_206830" ], "modifiers": [ [ "species_207020", "catalyst" ] ], "additional_components": [ "P21525", "phospho-kay", "P18289", "phospho-Jra", "Q9VLT9", "CKA", "P92208", "bsk", "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q9VLT9", "CKA", "P92208", "bsk", "P21525", "phospho-kay", "P18289", "phospho-Jra", "Q9VLT9", "CKA", "P92208", "bsk" ] }, "reaction_209193": { "compartment": "compartment_7660", "id": "reaction_209193", "reactome": "R-DME-209193", "name": "Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA", "reversible": "false", "notes": "The phosphorylated AP-1 transcription factor, JRA:KAY dissociates from the scaffolding protein CKA.", "reactants": [ "species_206830" ], "products": [ "species_206892", "species_206657" ], "modifiers": [], "additional_components": [ "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q9VLT9", "CKA", "P92208", "bsk", "Q9VLT9", "CKA", "P92208", "bsk", "P18289", "phospho-Jra", "P21525", "phospho-kay" ] }, "reaction_209358": { "compartment": "compartment_7660", "id": "reaction_209358", "reactome": "R-DME-209358", "name": "Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription", "reversible": "false", "notes": "The phosphorylated AP-1 transcription factor binds to its target genes and activates transcription. One of its target genes encodes the phosphatase Puckered (PUC) which acts as a negative regulator of the pathway as part of a negative feedback loop.In the eye, another transcriptional target, arising from the Frizzled (FZ):Dishevelled (DSH) complex activation in R3 cells, is for the Notch (N) receptor ligand Delta (DL). This will subsequently bind to its receptor N in the neighbouring R4 cell.", "reactants": [ "species_206657" ], "products": [ "species_206657" ], "modifiers": [], "additional_components": [ "P18289", "phospho-Jra", "P21525", "phospho-kay", "P18289", "phospho-Jra", "P21525", "phospho-kay" ] }, "reaction_209298": { "compartment": "compartment_70101", "id": "reaction_209298", "reactome": "R-DME-209298", "name": "BSK is phosphorylated and activated by phosphorylated HEP kinase", "reversible": "false", "notes": "Basket (BSK) is phosphorylated and activated when residues Thr181 and Tyr183 (Thr183 an Tyr185 in human JNK1) are phosphorylated by dual-specificity kinase, Hemipterous (HEP).", "reactants": [ "species_206638", "species_113592" ], "products": [ "species_29370", "species_206913" ], "modifiers": [ [ "species_206638", "catalyst" ] ], "additional_components": [ "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA", "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA", "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA" ] }, "reaction_209302": { "compartment": "compartment_70101", "id": "reaction_209302", "reactome": "R-DME-209302", "name": "Phosphorylated BSK kinase dissociates from CKA scaffolding protein", "reversible": "false", "notes": "The phosphorylation of the scaffold protein CKA probably results in a conformational change resulting in the dissociation of the phosphorylated Basket (BSK) kinase.", "reactants": [ "species_206943" ], "products": [ "species_206789", "species_206213" ], "modifiers": [], "additional_components": [ "Q23977", "Phospho HEP", "Q9VLT9", "CKA", "P92208", "bsk", "Q23977", "Phospho HEP", "Q9VLT9", "CKA" ] }, "reaction_209157": { "compartment": "compartment_70101", "id": "reaction_209157", "reactome": "R-DME-209157", "name": "Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase", "reversible": "false", "notes": "The JUN kinase phosphatase Puckered (PUC) dephosphorylates and consequently deactivates the phosphorylated Basket (BSK) kinase. The gene that encodes PUC is a target of the AP-1 transcription factor making this interaction part of a regulatory negative feedback loop.", "reactants": [ "species_206213" ], "products": [ "species_29372", "species_206251" ], "modifiers": [ [ "species_205899", "catalyst" ] ], "additional_components": [] }, "reaction_209183": { "compartment": "compartment_70101", "id": "reaction_209183", "reactome": "R-DME-209183", "name": "Scaffolding protein CKA binds BSK and phosphorylated HEP kinases", "reversible": "false", "notes": "The multidomain scaffolding protein, connector of kinase to AP-1 (CKA) binds phosphorylated Hemipterous (HEP) and the MAP kinase/JNK orthologue, Basket (BSK).", "reactants": [ "species_205833", "species_206251", "species_205776" ], "products": [ "species_206638" ], "modifiers": [], "additional_components": [ "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA" ] }, "reaction_209199": { "compartment": "compartment_70101", "id": "reaction_209199", "reactome": "R-DME-209199", "name": "CKA is phosphorylated by phosphorylated BSK kinase", "reversible": "false", "notes": "The scaffolding protein CKA is phosphorylated by phosphorylated Basket (BSK) kinase.", "reactants": [ "species_113592", "species_206913" ], "products": [ "species_206943", "species_29370" ], "modifiers": [ [ "species_206913", "catalyst" ] ], "additional_components": [ "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA", "Q23977", "Phospho HEP", "Q9VLT9", "CKA", "P92208", "bsk", "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA" ] }, "reaction_10439486": { "compartment": "compartment_7660", "id": "reaction_10439486", "reactome": "R-DME-188371", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438214", "species_10427405" ], "products": [ "species_10438216" ], "modifiers": [], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438221": { "compartment": "compartment_7660", "id": "reaction_10438221", "reactome": "R-DME-174079", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438216" ], "products": [ "species_113582", "species_10438218" ], "modifiers": [ [ "species_10438216", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438380": { "compartment": "compartment_7660", "id": "reaction_10438380", "reactome": "R-DME-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438212" ], "products": [ "species_113582", "species_10438066" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "FBgn0262699", "FBgn0262699", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10435471": { "compartment": "compartment_70101", "id": "reaction_10435471", "reactome": "R-DME-141423", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427579", "species_10435467" ], "products": [ "species_10435469" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10435477": { "compartment": "compartment_70101", "id": "reaction_10435477", "reactome": "R-DME-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435460", "species_10435465", "species_10435450", "species_10435455" ], "products": [ "species_10435467" ], "modifiers": [], "additional_components": [ "FBgn0001086", "FBgn0035640", "FBgn0263855", "FBgn0025457", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086" ] }, "reaction_10435475": { "compartment": "compartment_70101", "id": "reaction_10435475", "reactome": "R-DME-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435460", "species_10435465" ], "products": [ "species_10435473" ], "modifiers": [], "additional_components": [ "FBgn0001086", "FBgn0035640", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086" ] }, "reaction_10438247": { "compartment": "compartment_7660", "id": "reaction_10438247", "reactome": "R-DME-174097", "name": "Association of Emi1 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438243", "species_10436108" ], "products": [ "species_10438245" ], "modifiers": [], "additional_components": [ "Q9W4H9", "FBgn0262699", "FBgn0017551", "Q9VM76", "FBgn0017551", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438310": { "compartment": "compartment_7660", "id": "reaction_10438310", "reactome": "R-DME-174139", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438102" ], "products": [ "species_10438066", "species_10438100" ], "modifiers": [], "additional_components": [ "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438374": { "compartment": "compartment_7660", "id": "reaction_10438374", "reactome": "R-DME-174235", "name": "Association of Emi1 with Cdc20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438282", "species_10436108" ], "products": [ "species_10438372" ], "modifiers": [], "additional_components": [ "FBgn0001086", "FBgn0017551", "Q9VM76", "FBgn0017551", "Q24044", "FBgn0001086" ] }, "reaction_10438361": { "compartment": "compartment_7660", "id": "reaction_10438361", "reactome": "R-DME-174174", "name": "Phosphorylation of the Emi1 DSGxxS degron by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438286" ], "products": [ "species_113582", "species_10438359" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "Q9VM76", "FBgn0017551", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q9VM76", "FBgn0017551", "FBgn0003124" ] }, "reaction_10438294": { "compartment": "compartment_7660", "id": "reaction_10438294", "reactome": "R-DME-174122", "name": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438286" ], "products": [ "species_113582", "species_10438291" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q9VM76", "FBgn0017551", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q9VM76", "FBgn0017551", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10438382": { "compartment": "compartment_70101", "id": "reaction_10438382", "reactome": "R-DME-174255", "name": "Degradation multiubiquitinated Cyclin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438253" ], "products": [ "species_10434593", "species_10426987", "species_10435469" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106", "FBgn0004106", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10438355": { "compartment": "compartment_70101", "id": "reaction_10438355", "reactome": "R-DME-174171", "name": "Association of Cyclin A with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438249", "species_10435469" ], "products": [ "species_10438251" ], "modifiers": [], "additional_components": [ "P23572", "FBgn0004106", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106" ] }, "reaction_10438256": { "compartment": "compartment_70101", "id": "reaction_10438256", "reactome": "R-DME-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10438251" ], "products": [ "species_10438253" ], "modifiers": [ [ "species_10435469", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10439023": { "compartment": "compartment_70101", "id": "reaction_10439023", "reactome": "R-DME-179417", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439016", "species_10426987" ], "products": [ "species_10439020" ], "modifiers": [ [ "species_10439016", "catalyst" ] ], "additional_components": [ "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970" ] }, "reaction_10439018": { "compartment": "compartment_70101", "id": "reaction_10439018", "reactome": "R-DME-179410", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439014", "species_10435469" ], "products": [ "species_10439016" ], "modifiers": [], "additional_components": [ "FBgn0029970", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970" ] }, "reaction_10439025": { "compartment": "compartment_70101", "id": "reaction_10439025", "reactome": "R-DME-179421", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439020" ], "products": [ "species_10426987", "species_10435469" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10438378": { "compartment": "compartment_70101", "id": "reaction_10438378", "reactome": "R-DME-174238", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435469" ], "products": [ "species_10438276", "species_10438376" ], "modifiers": [], "additional_components": [ "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640" ] }, "reaction_10438280": { "compartment": "compartment_70101", "id": "reaction_10438280", "reactome": "R-DME-174120", "name": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438276", "species_10437675" ], "products": [ "species_10438278" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086" ] }, "reaction_10438325": { "compartment": "compartment_70101", "id": "reaction_10438325", "reactome": "R-DME-174157", "name": "Degradation of multiubiquitinated Cyclin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438323" ], "products": [ "species_10434593", "species_10438276", "species_10426987" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "FBgn0004106", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10438370": { "compartment": "compartment_70101", "id": "reaction_10438370", "reactome": "R-DME-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438278", "species_10426987" ], "products": [ "species_10438323" ], "modifiers": [ [ "species_10438276", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086" ] }, "reaction_10438366": { "compartment": "compartment_70101", "id": "reaction_10438366", "reactome": "R-DME-174202", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438318" ], "products": [ "species_10438276", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10438321": { "compartment": "compartment_70101", "id": "reaction_10438321", "reactome": "R-DME-174144", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438314", "species_10426987" ], "products": [ "species_10438318" ], "modifiers": [ [ "species_10438276", "catalyst" ] ], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086" ] }, "reaction_10438308": { "compartment": "compartment_7660", "id": "reaction_10438308", "reactome": "R-DME-174132", "name": "Free APC/C phosphorylated by Cyclin B:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438100" ], "products": [ "species_10438100" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10438274": { "compartment": "compartment_7660", "id": "reaction_10438274", "reactome": "R-DME-174119", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438100" ], "products": [ "species_10438100" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "FBgn0003124" ] }, "reaction_10438107": { "compartment": "compartment_7660", "id": "reaction_10438107", "reactome": "R-DME-174057", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10438102" ], "products": [ "species_10438104" ], "modifiers": [ [ "species_10438102", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438208": { "compartment": "compartment_7660", "id": "reaction_10438208", "reactome": "R-DME-174058", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438104" ], "products": [ "species_10438100", "species_10427430" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10438306": { "compartment": "compartment_70101", "id": "reaction_10438306", "reactome": "R-DME-174124", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10438296" ], "products": [ "species_111294", "species_10427584" ], "modifiers": [ [ "species_10438303", "catalyst" ] ], "additional_components": [ "FBgn0262699", "FBgn0262699" ] }, "reaction_10438210": { "compartment": "compartment_70101", "id": "reaction_10438210", "reactome": "R-DME-174070", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427584", "species_10427579" ], "products": [ "species_10427586" ], "modifiers": [], "additional_components": [ "FBgn0262699", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438368": { "compartment": "compartment_70101", "id": "reaction_10438368", "reactome": "R-DME-174224", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438276" ], "products": [ "species_10435460", "species_10427579" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10498544": { "compartment": "compartment_7660", "id": "reaction_10498544", "reactome": "R-DME-9686969", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498541", "species_10427430" ], "products": [ "species_10439482" ], "modifiers": [ [ "species_10498541", "catalyst" ] ], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438364": { "compartment": "compartment_70101", "id": "reaction_10438364", "reactome": "R-DME-174195", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10438239" ], "products": [ "species_10438258" ], "modifiers": [ [ "species_10438239", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438260": { "compartment": "compartment_70101", "id": "reaction_10438260", "reactome": "R-DME-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438258" ], "products": [ "species_10427586", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10438241": { "compartment": "compartment_70101", "id": "reaction_10438241", "reactome": "R-DME-174088", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427586", "species_10438237" ], "products": [ "species_10438239" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699" ] }, "reaction_10472877": { "compartment": "compartment_70101", "id": "reaction_10472877", "reactome": "R-DME-5607722", "name": "Active NIK phosphorylates IKKA dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10472874", "species_10446829" ], "products": [ "species_29370", "species_10472862" ], "modifiers": [ [ "species_10446829", "catalyst" ] ], "additional_components": [ "Q9VEZ5", "phospho-IKKbeta", "FBgn0024329", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "FBgn0024329" ] }, "reaction_10472872": { "compartment": "compartment_70101", "id": "reaction_10472872", "reactome": "R-DME-5607721", "name": "Activation of NIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446829" ], "products": [ "species_10446829" ], "modifiers": [], "additional_components": [ "FBgn0024329", "FBgn0024329" ] }, "reaction_10472920": { "compartment": "compartment_70101", "id": "reaction_10472920", "reactome": "R-DME-5607731", "name": "26S proteasome processes p-7S-p100:RELB to form p52:RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472913" ], "products": [ "species_10472918", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "P15330", "dl", "Q94527", "Rel", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10472935": { "compartment": "compartment_7660", "id": "reaction_10472935", "reactome": "R-DME-5607741", "name": "p52:RELB translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472918" ], "products": [ "species_10472933" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P15330", "dl", "Q94527", "Rel", "P15330", "dl" ] }, "reaction_10472870": { "compartment": "compartment_70101", "id": "reaction_10472870", "reactome": "R-DME-5607720", "name": "p100:RELB binds active NIK:p-IKKA dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472866", "species_10472862" ], "products": [ "species_10472868" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P15330", "dl", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl" ] }, "reaction_10472916": { "compartment": "compartment_70101", "id": "reaction_10472916", "reactome": "R-DME-5607726", "name": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472868", "species_113592" ], "products": [ "species_29370", "species_10472890" ], "modifiers": [ [ "species_10472868", "catalyst" ] ], "additional_components": [ "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl" ] }, "reaction_10475005": { "compartment": "compartment_70101", "id": "reaction_10475005", "reactome": "R-DME-5654573", "name": "Activated FGFR1 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465461", "species_10474909" ], "products": [ "species_10475003" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475036": { "compartment": "compartment_70101", "id": "reaction_10475036", "reactome": "R-DME-5654600", "name": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475031", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296" ] }, "reaction_10475033": { "compartment": "compartment_876", "id": "reaction_10475033", "reactome": "R-DME-5654597", "name": "Activated FGFR1:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475013" ], "products": [ "species_10475031" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296" ] }, "reaction_10475016": { "compartment": "compartment_70101", "id": "reaction_10475016", "reactome": "R-DME-5654582", "name": "Activated FGFR1 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475003" ], "products": [ "species_29370", "species_10475013" ], "modifiers": [ [ "species_10475003", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10434311": { "compartment": "compartment_70101", "id": "reaction_10434311", "reactome": "R-DME-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434307" ], "products": [ "species_10434309", "species_10434303" ], "modifiers": [], "additional_components": [ "species_30389", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "species_30389", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10433343": { "compartment": "compartment_5460", "id": "reaction_10433343", "reactome": "R-DME-109338", "name": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77358" ], "products": [ "species_77360" ], "modifiers": [ [ "species_10433340", "catalyst" ] ], "additional_components": [ "Q9VL68", "FBgn0032160" ] }, "reaction_10433820": { "compartment": "compartment_5460", "id": "reaction_10433820", "reactome": "R-DME-109998", "name": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109994" ], "products": [ "species_77343" ], "modifiers": [ [ "species_10433340", "catalyst" ] ], "additional_components": [ "Q9VL68", "FBgn0032160" ] }, "reaction_10433345": { "compartment": "compartment_5460", "id": "reaction_10433345", "reactome": "R-DME-109341", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_109986" ], "products": [ "species_109990", "species_31649" ], "modifiers": [ [ "species_10433219", "catalyst" ] ], "additional_components": [ "Q9VSA3", "FBgn0035811" ] }, "reaction_10469608": { "compartment": "compartment_7660", "id": "reaction_10469608", "reactome": "R-DME-4085372", "name": "PIAS1 SUMOylates SAFB with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469602", "species_10467300" ], "products": [ "species_10467222", "species_10469606" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0039229", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "FBgn0039229", "FBgn0003612" ] }, "reaction_10469156": { "compartment": "compartment_7660", "id": "reaction_10469156", "reactome": "R-DME-3900194", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429510", "species_10467290" ], "products": [ "species_10469153", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0035720", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0035720", "FBgn0010602", "FBgn0003612" ] }, "reaction_10467491": { "compartment": "compartment_7660", "id": "reaction_10467491", "reactome": "R-DME-3108203", "name": "PRC1 SUMOylates CTBP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10467421" ], "products": [ "species_10467424", "species_10467222" ], "modifiers": [ [ "species_10467488", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0020496", "FBgn0020496", "FBgn0010602", "P26017", "FBgn0003042", "Q9VB08", "FBgn0003330", "Q9VHA0", "FBgn0003334", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "P39769", "FBgn0004861", "Q9VKL0", "FBgn0032330", "Q9W523", "FBgn0004860" ] }, "reaction_10469619": { "compartment": "compartment_7660", "id": "reaction_10469619", "reactome": "R-DME-4086059", "name": "SUMOylation of NPM1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469613" ], "products": [ "species_10469616", "species_10467222" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0016685", "FBgn0016685", "FBgn0010602", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10471853": { "compartment": "compartment_7660", "id": "reaction_10471853", "reactome": "R-DME-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427633", "species_10471849", "species_10471835" ], "products": [ "species_10471851" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655" ] }, "reaction_10471868": { "compartment": "compartment_7660", "id": "reaction_10471868", "reactome": "R-DME-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_5358610" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10427699", "catalyst" ] ], "additional_components": [ "FBgn0262619" ] }, "reaction_10471882": { "compartment": "compartment_7660", "id": "reaction_10471882", "reactome": "R-DME-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10471862" ], "products": [ "species_113582", "species_10471849" ], "modifiers": [], "additional_components": [ "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546" ] }, "reaction_10471864": { "compartment": "compartment_7660", "id": "reaction_10471864", "reactome": "R-DME-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471860", "species_5358514" ], "products": [ "species_10471862" ], "modifiers": [], "additional_components": [ "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370", "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370" ] }, "reaction_10471880": { "compartment": "compartment_7660", "id": "reaction_10471880", "reactome": "R-DME-5358599", "name": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_10471875" ], "products": [ "species_10471866" ], "modifiers": [ [ "species_10471875", "catalyst" ] ], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "Q24558", "FBgn0015553", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "Q24558", "FBgn0015553" ] }, "reaction_10471877": { "compartment": "compartment_7660", "id": "reaction_10471877", "reactome": "R-DME-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471873", "species_10471855" ], "products": [ "species_10471875" ], "modifiers": [], "additional_components": [ "FBgn0015553", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "Q24558", "FBgn0015553" ] }, "reaction_10472562": { "compartment": "compartment_7660", "id": "reaction_10472562", "reactome": "R-DME-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471828", "species_10471833" ], "products": [ "species_10471835" ], "modifiers": [], "additional_components": [ "FBgn0011659", "FBgn0011660", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659" ] }, "reaction_10471858": { "compartment": "compartment_7660", "id": "reaction_10471858", "reactome": "R-DME-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471851" ], "products": [ "species_10471855" ], "modifiers": [ [ "species_10471851", "catalyst" ] ], "additional_components": [ "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655" ] }, "reaction_10472560": { "compartment": "compartment_7660", "id": "reaction_10472560", "reactome": "R-DME-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10471840", "species_10471845" ], "products": [ "species_10471860" ], "modifiers": [], "additional_components": [ "FBgn0015546", "FBgn0036486", "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370" ] }, "reaction_10473069": { "compartment": "compartment_70101", "id": "reaction_10473069", "reactome": "R-DME-5610737", "name": "NUMB:ITCH bind and ubiquitnate GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473061", "species_10473055" ], "products": [ "species_10473066" ], "modifiers": [ [ "species_10473055", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9VG38", "FBgn0005355", "P19538", "ci", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10473111": { "compartment": "compartment_70101", "id": "reaction_10473111", "reactome": "R-DME-5610760", "name": "GLI1 is degraded by the proteasome after ubiquitination by ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473066" ], "products": [ "species_10472994", "species_10473055" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0005355", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10473109": { "compartment": "compartment_70101", "id": "reaction_10473109", "reactome": "R-DME-5610758", "name": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473071" ], "products": [ "species_10472994" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0005355", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10473073": { "compartment": "compartment_5263232", "id": "reaction_10473073", "reactome": "R-DME-5610742", "name": "SCF(beta-TrCP) ubiquitinates p-GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473061", "species_10426987" ], "products": [ "species_10473071" ], "modifiers": [ [ "species_10442677", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10473057": { "compartment": "compartment_70101", "id": "reaction_10473057", "reactome": "R-DME-5610735", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456470", "species_10473053" ], "products": [ "species_10473055" ], "modifiers": [], "additional_components": [ "FBgn0003557", "FBgn0002973", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10491420": { "compartment": "compartment_70101", "id": "reaction_10491420", "reactome": "R-DME-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10491417", "catalyst" ] ], "additional_components": [ "FBgn0023522" ] }, "reaction_10456032": { "compartment": "compartment_70101", "id": "reaction_10456032", "reactome": "R-DME-977301", "name": "Histidine is decarboxylated to histamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_175992", "species_113528" ], "modifiers": [ [ "species_10456029", "catalyst" ] ], "additional_components": [ "Q05733", "FBgn0005619" ] }, "reaction_10464665": { "compartment": "compartment_984", "id": "reaction_10464665", "reactome": "R-DME-2046239", "name": "Extracellular KSPG translocates to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464621" ], "products": [ "species_10461390" ], "modifiers": [], "additional_components": [ "FBgn0028872", "FBgn0028872" ] }, "reaction_10460806": { "compartment": "compartment_161320", "id": "reaction_10460806", "reactome": "R-DME-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10460515", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10497913": { "compartment": "compartment_161320", "id": "reaction_10497913", "reactome": "R-DME-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10460517", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10460725": { "compartment": "compartment_161320", "id": "reaction_10460725", "reactome": "R-DME-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104997" ], "products": [ "species_1605637", "species_2104995" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_10460803": { "compartment": "compartment_161320", "id": "reaction_10460803", "reactome": "R-DME-1638032", "name": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104995" ], "products": [ "species_1606845", "species_2105012" ], "modifiers": [ [ "species_10460800", "catalyst" ] ], "additional_components": [ "FBgn0033836" ] }, "reaction_10453964": { "compartment": "compartment_20699", "id": "reaction_10453964", "reactome": "R-DME-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744229", "species_735698" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10453959", "catalyst" ] ], "additional_components": [ "species_744227", "species_914003", "species_744227", "species_914003", "FBgn0042641" ] }, "reaction_10464619": { "compartment": "compartment_20699", "id": "reaction_10464619", "reactome": "R-DME-2046175", "name": "Further sulfation on galactose residues produces KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10464596" ], "products": [ "species_742343", "species_10464606" ], "modifiers": [ [ "species_10464616", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "FBgn0051637" ] }, "reaction_10463991": { "compartment": "compartment_20699", "id": "reaction_10463991", "reactome": "R-DME-2025724", "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10463960" ], "products": [ "species_10463973", "species_205687" ], "modifiers": [ [ "species_10463988", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q95RP8", "FBgn0040373", "A1Z8R6", "FBgn0053145", "A1Z8R5", "FBgn0050037", "A1Z8R4", "FBgn0050036", "Q9VZA6", "FBgn0035558", "Q9VLT0", "FBgn0031986", "Q9VLS8", "FBgn0031988", "Q9W1A7", "FBgn0041706" ] }, "reaction_10464663": { "compartment": "compartment_20699", "id": "reaction_10464663", "reactome": "R-DME-2046222", "name": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10464634" ], "products": [ "species_742343", "species_10464596" ], "modifiers": [ [ "species_10464660", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VMC4", "FBgn0031826", "Q9VMC3", "FBgn0051637" ] }, "reaction_10464631": { "compartment": "compartment_17963", "id": "reaction_10464631", "reactome": "R-DME-2046180", "name": "KSPG is secreted from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464606" ], "products": [ "species_10464621" ], "modifiers": [], "additional_components": [ "FBgn0028872", "FBgn0028872" ] }, "reaction_10464678": { "compartment": "compartment_20699", "id": "reaction_10464678", "reactome": "R-DME-2046265", "name": "B4GALTs transfer Gal to the keratan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463973", "species_735682" ], "products": [ "species_205687", "species_10464668" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10464691": { "compartment": "compartment_20699", "id": "reaction_10464691", "reactome": "R-DME-2046298", "name": "B4GALTs transfer Gal to a branch of keratan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10464668" ], "products": [ "species_10464681", "species_205687" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10463970": { "compartment": "compartment_20699", "id": "reaction_10463970", "reactome": "R-DME-2025723", "name": "B4GALTs transfer Gal to the N-glycan precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10463949" ], "products": [ "species_10463960", "species_205687" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10440396": { "compartment": "compartment_70101", "id": "reaction_10440396", "reactome": "R-DME-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440394": { "compartment": "compartment_70101", "id": "reaction_10440394", "reactome": "R-DME-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440392": { "compartment": "compartment_70101", "id": "reaction_10440392", "reactome": "R-DME-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9617026" ], "products": [ "species_193829", "species_29366" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440390": { "compartment": "compartment_70101", "id": "reaction_10440390", "reactome": "R-DME-193816", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192194" ], "products": [ "species_70106", "species_193835", "species_73473" ], "modifiers": [ [ "species_10440112", "catalyst" ] ], "additional_components": [ "FBgn0036698" ] }, "reaction_10440388": { "compartment": "compartment_70101", "id": "reaction_10440388", "reactome": "R-DME-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10434826": { "compartment": "compartment_7660", "id": "reaction_10434826", "reactome": "R-DME-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427460" ], "products": [ "species_113656", "species_10427272" ], "modifiers": [], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113" ] }, "reaction_10439755": { "compartment": "compartment_984", "id": "reaction_10439755", "reactome": "R-DME-190265", "name": "FGFR4 binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439749", "species_10433467", "species_190915" ], "products": [ "species_10439753" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10458927": { "compartment": "compartment_876", "id": "reaction_10458927", "reactome": "R-DME-1307963", "name": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10458922" ], "products": [ "species_10433616", "species_29370" ], "modifiers": [ [ "species_10458922", "catalyst" ] ], "additional_components": [ "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10458924": { "compartment": "compartment_70101", "id": "reaction_10458924", "reactome": "R-DME-1307955", "name": "FGFR4 binds HS:KLB:FGF19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439749", "species_10433610", "species_190915", "species_10433614" ], "products": [ "species_10458922" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "FBgn0036659", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10439762": { "compartment": "compartment_876", "id": "reaction_10439762", "reactome": "R-DME-190326", "name": "Autocatalytic phosphorylation of FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439753" ], "products": [ "species_29370", "species_10433612" ], "modifiers": [ [ "species_10439753", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474842": { "compartment": "compartment_876", "id": "reaction_10474842", "reactome": "R-DME-5654163", "name": "Activated FGFR4 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10439290", "species_10465485" ], "products": [ "species_10474831" ], "modifiers": [], "additional_components": [ "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474836": { "compartment": "compartment_70101", "id": "reaction_10474836", "reactome": "R-DME-5654151", "name": "Activated FGFR4 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474831" ], "products": [ "species_10474833", "species_29370" ], "modifiers": [ [ "species_10474831", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_179838", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474848": { "compartment": "compartment_876", "id": "reaction_10474848", "reactome": "R-DME-5654169", "name": "p-4Y-PLCG1 dissociates from activated FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474833" ], "products": [ "species_10441915", "species_10465485" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10475119": { "compartment": "compartment_70101", "id": "reaction_10475119", "reactome": "R-DME-5654659", "name": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465487" ], "products": [ "species_10465489" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475132": { "compartment": "compartment_70101", "id": "reaction_10475132", "reactome": "R-DME-5654667", "name": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10475128" ], "products": [ "species_10475130" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475188": { "compartment": "compartment_70101", "id": "reaction_10475188", "reactome": "R-DME-5654717", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465491", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10438947": { "compartment": "compartment_70101", "id": "reaction_10438947", "reactome": "R-DME-177931", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431812", "species_10438839" ], "products": [ "species_10438945" ], "modifiers": [], "additional_components": [ "FBgn0020622", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475185": { "compartment": "compartment_70101", "id": "reaction_10475185", "reactome": "R-DME-5654714", "name": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10475182", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475103": { "compartment": "compartment_70101", "id": "reaction_10475103", "reactome": "R-DME-5654651", "name": "Activated FGFR4 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474997", "species_10465485" ], "products": [ "species_10475101" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475117": { "compartment": "compartment_876", "id": "reaction_10475117", "reactome": "R-DME-5654655", "name": "Activated FGFR4 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475112" ], "products": [ "species_29370", "species_10475114" ], "modifiers": [ [ "species_10475112", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10475126": { "compartment": "compartment_70101", "id": "reaction_10475126", "reactome": "R-DME-5654664", "name": "Activated FGFR4:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475110" ], "products": [ "species_10475121" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474949": { "compartment": "compartment_70101", "id": "reaction_10474949", "reactome": "R-DME-5654422", "name": "Activated FGFR4 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474873", "species_10465485" ], "products": [ "species_10474941" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475108": { "compartment": "compartment_876", "id": "reaction_10475108", "reactome": "R-DME-5654653", "name": "Activated FGFR4 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475101" ], "products": [ "species_10475105", "species_29370" ], "modifiers": [ [ "species_10475101", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475124": { "compartment": "compartment_70101", "id": "reaction_10475124", "reactome": "R-DME-5654663", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475121", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474946": { "compartment": "compartment_876", "id": "reaction_10474946", "reactome": "R-DME-5654418", "name": "Activated FGFR4 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474941" ], "products": [ "species_29370", "species_10465487" ], "modifiers": [ [ "species_10474941", "catalyst" ], [ "species_10474944", "inhibitor" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10493199": { "compartment": "compartment_70101", "id": "reaction_10493199", "reactome": "R-DME-8941613", "name": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475114", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10474959": { "compartment": "compartment_70101", "id": "reaction_10474959", "reactome": "R-DME-5654425", "name": "Activated FGFR4 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474909", "species_10465485" ], "products": [ "species_10474957" ], "modifiers": [], "additional_components": [ "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10474955": { "compartment": "compartment_876", "id": "reaction_10474955", "reactome": "R-DME-5654423", "name": "Activated FGFR4:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10474951" ], "products": [ "species_10474953" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474965": { "compartment": "compartment_70101", "id": "reaction_10474965", "reactome": "R-DME-5654428", "name": "Activated FGFR4 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474957" ], "products": [ "species_29370", "species_10474951" ], "modifiers": [ [ "species_10474957", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10474962": { "compartment": "compartment_70101", "id": "reaction_10474962", "reactome": "R-DME-5654426", "name": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474953", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475194": { "compartment": "compartment_70101", "id": "reaction_10475194", "reactome": "R-DME-5654734", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439154", "species_10475128" ], "products": [ "species_10475157" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10475162": { "compartment": "compartment_70101", "id": "reaction_10475162", "reactome": "R-DME-5654684", "name": "CBL ubiquitinates FRS2 and FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475157", "species_10426987" ], "products": [ "species_10475159" ], "modifiers": [ [ "species_10475157", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10458638": { "compartment": "compartment_70101", "id": "reaction_10458638", "reactome": "R-DME-1295634", "name": "SPRY2 is serine phosphorylated in response to MAPK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458630" ], "products": [ "species_10458603" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "O44783", "FBgn0014388", "P11346", "Raf", "O44783", "FBgn0014388", "P40417", "FBgn0003256" ] }, "reaction_10458605": { "compartment": "compartment_70101", "id": "reaction_10458605", "reactome": "R-DME-1295604", "name": "B-RAF dissociates from S111/S120 p-SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458603" ], "products": [ "species_10458599", "species_10458601" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "O44783", "FBgn0014388", "FBgn0014388" ] }, "reaction_10458620": { "compartment": "compartment_70101", "id": "reaction_10458620", "reactome": "R-DME-1295622", "name": "SPRY2 binds CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10458607" ], "products": [ "species_10455248", "species_10455223" ], "modifiers": [], "additional_components": [ "FBgn0020224", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10455243": { "compartment": "compartment_70101", "id": "reaction_10455243", "reactome": "R-DME-934559", "name": "SPRY2 is phosphorylated by phosphorylated MNK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10455225" ], "products": [ "species_29370", "species_10455231" ], "modifiers": [ [ "species_10455240", "catalyst" ] ], "additional_components": [ "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "FBgn0017581" ] }, "reaction_10458618": { "compartment": "compartment_70101", "id": "reaction_10458618", "reactome": "R-DME-1295621", "name": "CBL dissociates from ubiquitinated p-SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455250" ], "products": [ "species_10458616", "species_10439032" ], "modifiers": [], "additional_components": [ "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0020224" ] }, "reaction_10458614": { "compartment": "compartment_70101", "id": "reaction_10458614", "reactome": "R-DME-1295613", "name": "SPRY2 binds GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458607", "species_10431791" ], "products": [ "species_10458612" ], "modifiers": [], "additional_components": [ "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "FBgn0004638", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "Q08012", "FBgn0004638" ] }, "reaction_10455253": { "compartment": "compartment_70101", "id": "reaction_10455253", "reactome": "R-DME-934604", "name": "Phosphorylated SPRY2 is ubiquitinated by CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455248", "species_10426987" ], "products": [ "species_10455250" ], "modifiers": [ [ "species_10455248", "catalyst" ] ], "additional_components": [ "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224" ] }, "reaction_10458628": { "compartment": "compartment_70101", "id": "reaction_10458628", "reactome": "R-DME-1295632", "name": "PPA2A dephosphorylates SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458625" ], "products": [ "species_10458593", "species_29372" ], "modifiers": [ [ "species_10458625", "catalyst" ] ], "additional_components": [ "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10458595": { "compartment": "compartment_70101", "id": "reaction_10458595", "reactome": "R-DME-1295599", "name": "SPRY2 translocates to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458593" ], "products": [ "species_10455225" ], "modifiers": [], "additional_components": [ "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388" ] }, "reaction_10458609": { "compartment": "compartment_70101", "id": "reaction_10458609", "reactome": "R-DME-1295609", "name": "SRC phosphorylates SPRY2 on Y55 and Y227", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10455225" ], "products": [ "species_29370", "species_10458607" ], "modifiers": [ [ "species_10438975", "catalyst" ], [ "species_10455231", "inhibitor" ] ], "additional_components": [ "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "FBgn0262733", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10474993": { "compartment": "compartment_70101", "id": "reaction_10474993", "reactome": "R-DME-5654566", "name": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474941" ], "products": [ "species_10474944", "species_29370" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "P40417", "FBgn0003256" ] }, "reaction_10466163": { "compartment": "compartment_70101", "id": "reaction_10466163", "reactome": "R-DME-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466159" ], "products": [ "species_29370", "species_10466149" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "Q9V3A7", "FBgn0015391", "A1Z987", "FBgn0259876", "Q9VIP9", "FBgn0014127", "Q9VAJ1", "FBgn0039680", "Q7KK96", "FBgn0027783", "Q9VIP9", "FBgn0014127", "A1Z987", "FBgn0259876", "Q7KK96", "FBgn0027783", "Q9VAJ1", "FBgn0039680", "Q9V3A7", "FBgn0015391", "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10466161": { "compartment": "compartment_70101", "id": "reaction_10466161", "reactome": "R-DME-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10466149" ], "products": [ "species_29372", "species_10466159" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q9VIP9", "FBgn0014127", "A1Z987", "FBgn0259876", "Q7KK96", "FBgn0027783", "Q9VAJ1", "FBgn0039680", "Q9V3A7", "FBgn0015391", "Q9V3A7", "FBgn0015391", "A1Z987", "FBgn0259876", "Q9VIP9", "FBgn0014127", "Q9VAJ1", "FBgn0039680", "Q7KK96", "FBgn0027783" ] }, "reaction_10435527": { "compartment": "compartment_7660", "id": "reaction_10435527", "reactome": "R-DME-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435521", "species_113592" ], "products": [ "species_29370", "species_10435525" ], "modifiers": [ [ "species_10435513", "catalyst" ] ], "additional_components": [ "FBgn0021768", "FBgn0021768", "FBgn0003124" ] }, "reaction_10466047": { "compartment": "compartment_1598585", "id": "reaction_10466047", "reactome": "R-DME-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466044" ], "products": [ "species_29370", "species_10465943" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "A1Z8S6", "FBgn0260012", "Q9VCD8", "FBgn0040283", "O96689", "FBgn0260987", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "Q9VCD8", "FBgn0040283", "O96689", "FBgn0260987", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "Q9W517", "FBgn0004655", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10465958": { "compartment": "compartment_1598585", "id": "reaction_10465958", "reactome": "R-DME-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10465943" ], "products": [ "species_10465955", "species_29370" ], "modifiers": [ [ "species_10437677", "catalyst" ] ], "additional_components": [ "A1Z8S6", "FBgn0260012", "Q9VCD8", "FBgn0040283", "O96689", "FBgn0260987", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "Q9W517", "FBgn0004655", "O96689", "FBgn0260987", "Q9VCD8", "FBgn0040283", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "A1Z8S6", "FBgn0260012", "Q9W517", "FBgn0004655", "FBgn0003124" ] }, "reaction_10465193": { "compartment": "compartment_7660", "id": "reaction_10465193", "reactome": "R-DME-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10465179" ], "products": [ "species_113582", "species_10465182" ], "modifiers": [ [ "species_10465190", "catalyst" ] ], "additional_components": [ "FBgn0061515", "FBgn0061515", "FBgn0260399" ] }, "reaction_10465827": { "compartment": "compartment_7660", "id": "reaction_10465827", "reactome": "R-DME-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10465822" ], "products": [ "species_113582", "species_10465825" ], "modifiers": [ [ "species_10465190", "catalyst" ] ], "additional_components": [ "FBgn0061515", "FBgn0061515", "FBgn0260399" ] }, "reaction_10467211": { "compartment": "compartment_70101", "id": "reaction_10467211", "reactome": "R-DME-2990882", "name": "CDK1 phosphorylates NUP98", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432243", "species_113592" ], "products": [ "species_29370", "species_10467195" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10471162": { "compartment": "compartment_7660", "id": "reaction_10471162", "reactome": "R-DME-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10471135" ], "products": [ "species_113582", "species_10471160" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10470742": { "compartment": "compartment_7660", "id": "reaction_10470742", "reactome": "R-DME-5195402", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10469763" ], "products": [ "species_113582", "species_10469757" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "FBgn0263593", "FBgn0263593", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10469782": { "compartment": "compartment_13231", "id": "reaction_10469782", "reactome": "R-DME-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10469757" ], "products": [ "species_113550", "species_10469763" ], "modifiers": [ [ "species_10469779", "catalyst" ] ], "additional_components": [ "FBgn0263593", "FBgn0263593", "Q9VRG7", "FBgn0029067", "Q8T0B1", "FBgn0036090" ] }, "reaction_10471029": { "compartment": "compartment_13231", "id": "reaction_10471029", "reactome": "R-DME-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10469763", "catalyst" ] ], "additional_components": [ "FBgn0263593" ] }, "reaction_10445787": { "compartment": "compartment_7660", "id": "reaction_10445787", "reactome": "R-DME-380278", "name": "CCNB1:p-T160-CDK1 phosphorylates NUMA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10445775" ], "products": [ "species_113582", "species_10445785" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q9VGE4", "FBgn0037979", "Q8IR55", "FBgn0002873", "Q9VGE4", "FBgn0037979", "Q8IR55", "FBgn0002873", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10465453": { "compartment": "compartment_20699", "id": "reaction_10465453", "reactome": "R-DME-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465445", "species_113592" ], "products": [ "species_29370", "species_10465450" ], "modifiers": [ [ "species_10465445", "catalyst" ] ], "additional_components": [ "P52304", "FBgn0003124", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "O18332", "FBgn0285937", "species_29438", "Q9W289", "FBgn0034697", "P52304", "FBgn0003124", "Q9VW57", "FBgn0036919", "O18332", "FBgn0285937", "species_29438", "P52304", "FBgn0003124", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "O18332", "FBgn0285937", "species_29438" ] }, "reaction_10465713": { "compartment": "compartment_20699", "id": "reaction_10465713", "reactome": "R-DME-2422927", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465698", "species_113592" ], "products": [ "species_29370", "species_10465704" ], "modifiers": [ [ "species_10465710", "catalyst" ] ], "additional_components": [ "Q9VHE3", "FBgn0037688", "Q9VW57", "FBgn0036919", "O18333", "FBgn0014009", "species_29438", "Q9VHE3", "FBgn0037688", "Q9VW57", "FBgn0036919", "O18333", "FBgn0014009", "species_29438" ] }, "reaction_10465820": { "compartment": "compartment_7660", "id": "reaction_10465820", "reactome": "R-DME-2429719", "name": "MCPH1 sequesters condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450944", "species_10465223", "species_10465816" ], "products": [ "species_10465818" ], "modifiers": [], "additional_components": [ "FBgn0014879", "Q9VMQ4", "FBgn0051989", "Q9V3A7", "FBgn0015391", "Q8INL2", "FBgn0037831", "Q7KK96", "FBgn0027783", "FBgn0260959", "E1JH39", "FBgn0260959", "Q9VMQ4", "FBgn0051989", "Q9V3A7", "FBgn0015391", "Q8INL2", "FBgn0037831", "Q7KK96", "FBgn0027783", "P53997", "FBgn0014879" ] }, "reaction_10498393": { "compartment": "compartment_70101", "id": "reaction_10498393", "reactome": "R-DME-9667965", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467266", "species_10455162" ], "products": [ "species_10498391" ], "modifiers": [], "additional_components": [ "FBgn0028343", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q8MQX9", "FBgn0028343" ] }, "reaction_10497739": { "compartment": "compartment_13231", "id": "reaction_10497739", "reactome": "R-DME-9624798", "name": "LBR binds KPNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497735", "species_10443115" ], "products": [ "species_10497737" ], "modifiers": [], "additional_components": [ "FBgn0034657", "FBgn0262743", "O18388", "FBgn0262743", "Q8MLV1", "FBgn0034657" ] }, "reaction_10497741": { "compartment": "compartment_70101", "id": "reaction_10497741", "reactome": "R-DME-9624800", "name": "CDK1 phosphorylates LBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440460" ], "products": [ "species_29370", "species_10497735" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "FBgn0034657", "FBgn0034657", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10467280": { "compartment": "compartment_70101", "id": "reaction_10467280", "reactome": "R-DME-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467266", "species_10467276" ], "products": [ "species_10467278" ], "modifiers": [], "additional_components": [ "FBgn0028343", "Q7KRY6", "FBgn0027889", "Q7KMI3", "FBgn0027504", "Q7KRY6", "FBgn0027889", "Q7KMI3", "FBgn0027504", "Q8MQX9", "FBgn0028343" ] }, "reaction_10498422": { "compartment": "compartment_70101", "id": "reaction_10498422", "reactome": "R-DME-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498413", "species_10498418" ], "products": [ "species_10498420" ], "modifiers": [], "additional_components": [ "Q8I0P1", "FBgn0039141", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "FBgn0283469", "Q9Y162", "FBgn0283469", "Q8I0P1", "FBgn0039141", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10498424": { "compartment": "compartment_13231", "id": "reaction_10498424", "reactome": "R-DME-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498409", "species_10498405" ], "products": [ "species_10498411" ], "modifiers": [], "additional_components": [ "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "FBgn0261983", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10498426": { "compartment": "compartment_70101", "id": "reaction_10498426", "reactome": "R-DME-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498411", "species_10498400" ], "products": [ "species_10498413" ], "modifiers": [], "additional_components": [ "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "FBgn0039141", "Q8I0P1", "FBgn0039141", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10497749": { "compartment": "compartment_1598585", "id": "reaction_10497749", "reactome": "R-DME-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10442325" ], "products": [ "species_10472625", "species_29420" ], "modifiers": [ [ "species_10497746", "catalyst" ] ], "additional_components": [ "species_29420", "Q9VZ23", "FBgn0020255", "Q9VZ23", "FBgn0020255", "species_29438", "FBgn0002638" ] }, "reaction_10497641": { "compartment": "compartment_70101", "id": "reaction_10497641", "reactome": "R-DME-9618378", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497596", "species_10432171" ], "products": [ "species_10497639" ], "modifiers": [], "additional_components": [ "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VWE6", "FBgn0031052", "FBgn0010660", "Q9W1X4", "FBgn0010660", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VWE6", "FBgn0031052" ] }, "reaction_10497753": { "compartment": "compartment_70101", "id": "reaction_10497753", "reactome": "R-DME-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472625", "species_9624879" ], "products": [ "species_10497751" ], "modifiers": [], "additional_components": [ "Q9VZ23", "FBgn0020255", "species_29438", "Q9VZ23", "FBgn0020255", "species_29438" ] }, "reaction_10497598": { "compartment": "compartment_70101", "id": "reaction_10497598", "reactome": "R-DME-9615901", "name": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10497594", "species_10432219" ], "products": [ "species_10497596" ], "modifiers": [], "additional_components": [ "FBgn0031052", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VWE6", "FBgn0031052" ] }, "reaction_10436113": { "compartment": "compartment_7660", "id": "reaction_10436113", "reactome": "R-DME-163010", "name": "Down Regulation of Emi1 through Phosphorylation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10436108" ], "products": [ "species_113582", "species_10436111" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0017551", "FBgn0017551", "FBgn0003124" ] }, "reaction_10466038": { "compartment": "compartment_7660", "id": "reaction_10466038", "reactome": "R-DME-2468040", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466008", "species_10466010", "species_10466014" ], "products": [ "species_10466016" ], "modifiers": [], "additional_components": [ "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "FBgn0260012", "FBgn0004655", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616" ] }, "reaction_10466067": { "compartment": "compartment_1598585", "id": "reaction_10466067", "reactome": "R-DME-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466016", "species_2537690", "species_10466059" ], "products": [ "species_10466065" ], "modifiers": [], "additional_components": [ "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q7PLI2", "FBgn0026401", "Q9VFC0", "FBgn0038300", "Q7PLI2", "FBgn0026401", "Q9VFC0", "FBgn0038300", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616" ] }, "reaction_10435497": { "compartment": "compartment_7660", "id": "reaction_10435497", "reactome": "R-DME-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10435484" ], "products": [ "species_113582", "species_10435488" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0011692", "FBgn0011692", "FBgn0003124" ] }, "reaction_10435542": { "compartment": "compartment_7660", "id": "reaction_10435542", "reactome": "R-DME-156723", "name": "Regulation of KIF20A (MKL2) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10435537" ], "products": [ "species_113582", "species_10435540" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0003545", "FBgn0003545", "FBgn0003124" ] }, "reaction_10448542": { "compartment": "compartment_70101", "id": "reaction_10448542", "reactome": "R-DME-428231", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428256" ], "products": [ "species_428193", "species_428198" ], "modifiers": [ [ "species_10448539", "catalyst" ] ], "additional_components": [ "FBgn0045064" ] }, "reaction_10478169": { "compartment": "compartment_12045", "id": "reaction_10478169", "reactome": "R-DME-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10478166", "catalyst" ] ], "additional_components": [ "FBgn0050502" ] }, "reaction_10448537": { "compartment": "compartment_70101", "id": "reaction_10448537", "reactome": "R-DME-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428163" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10448534", "catalyst" ] ], "additional_components": [ "Q9VYY8", "FBgn0030300", "Q9VZW0", "FBgn0052484" ] }, "reaction_10448919": { "compartment": "compartment_12045", "id": "reaction_10448919", "reactome": "R-DME-429699", "name": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448902", "species_428256" ], "products": [ "species_10448900" ], "modifiers": [], "additional_components": [ "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "species_429807", "Q9Y128", "FBgn0027569" ] }, "reaction_10498667": { "compartment": "compartment_70101", "id": "reaction_10498667", "reactome": "R-DME-9695890", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_419305" ], "modifiers": [ [ "species_10498664", "catalyst" ] ], "additional_components": [ "FBgn0086676" ] }, "reaction_10448914": { "compartment": "compartment_70101", "id": "reaction_10448914", "reactome": "R-DME-429694", "name": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448902" ], "products": [ "species_10448912", "species_10448891" ], "modifiers": [], "additional_components": [ "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515" ] }, "reaction_10448498": { "compartment": "compartment_70101", "id": "reaction_10448498", "reactome": "R-DME-428127", "name": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_9695889" ], "products": [ "species_113528", "species_76194", "species_428182" ], "modifiers": [ [ "species_10448490", "catalyst" ], [ "species_10448496", "inhibitor" ] ], "additional_components": [ "Q6NR46", "FBgn0086532", "Q9V3F2", "FBgn0002524", "A8DYH6", "FBgn0085223", "FBgn0037110" ] }, "reaction_10448464": { "compartment": "compartment_70101", "id": "reaction_10448464", "reactome": "R-DME-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10448461", "catalyst" ] ], "additional_components": [ "FBgn0039304" ] }, "reaction_10448656": { "compartment": "compartment_984", "id": "reaction_10448656", "reactome": "R-DME-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10448653", "catalyst" ] ], "additional_components": [ "FBgn0016078" ] }, "reaction_10498672": { "compartment": "compartment_70101", "id": "reaction_10498672", "reactome": "R-DME-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10448532", "catalyst" ], [ "species_10498670", "inhibitor" ] ], "additional_components": [ "Q9VYY8", "FBgn0030300", "Q9VZW0", "FBgn0052484", "Q9VYY8", "FBgn0030300", "Q9VZW0", "FBgn0052484" ] }, "reaction_10448909": { "compartment": "compartment_12045", "id": "reaction_10448909", "reactome": "R-DME-429683", "name": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448900" ], "products": [ "species_10448902", "species_428270" ], "modifiers": [ [ "species_10448907", "catalyst" ] ], "additional_components": [ "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "species_429807", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "FBgn0020626" ] }, "reaction_10448556": { "compartment": "compartment_70101", "id": "reaction_10448556", "reactome": "R-DME-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10446693", "catalyst" ] ], "additional_components": [ "FBgn0030300" ] }, "reaction_10448523": { "compartment": "compartment_20699", "id": "reaction_10448523", "reactome": "R-DME-428205", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428270" ], "products": [ "species_428248", "species_8934421" ], "modifiers": [ [ "species_10448520", "catalyst" ] ], "additional_components": [ "FBgn0045064" ] }, "reaction_10495317": { "compartment": "compartment_12045", "id": "reaction_10495317", "reactome": "R-DME-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10495314", "catalyst" ] ], "additional_components": [ "FBgn0052380" ] }, "reaction_10448553": { "compartment": "compartment_70101", "id": "reaction_10448553", "reactome": "R-DME-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428126", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9025544" ], "modifiers": [ [ "species_10448547", "catalyst" ] ], "additional_components": [ "FBgn0001941" ] }, "reaction_10448648": { "compartment": "compartment_70101", "id": "reaction_10448648", "reactome": "R-DME-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10448643", "catalyst" ] ], "additional_components": [ "FBgn0010591" ] }, "reaction_10448711": { "compartment": "compartment_70101", "id": "reaction_10448711", "reactome": "R-DME-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10448708", "catalyst" ] ], "additional_components": [ "Q9V576", "FBgn0016078", "Q9VNT8", "FBgn0037341", "Q9VNU1", "FBgn0037341", "Q9VNU0", "FBgn0037165", "Q7KGH1", "FBgn0041087", "Q9VNT9", "FBgn0037341", "Q9VNU2", "FBgn0037163" ] }, "reaction_10448550": { "compartment": "compartment_70101", "id": "reaction_10448550", "reactome": "R-DME-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10448547", "catalyst" ] ], "additional_components": [ "species_29362", "species_29364", "species_427523", "species_29366", "FBgn0001941" ] }, "reaction_10448646": { "compartment": "compartment_70101", "id": "reaction_10448646", "reactome": "R-DME-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428671", "species_428686" ], "modifiers": [ [ "species_10448643", "catalyst" ] ], "additional_components": [ "FBgn0010591" ] }, "reaction_10448932": { "compartment": "compartment_70101", "id": "reaction_10448932", "reactome": "R-DME-429732", "name": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448923", "species_10448891" ], "products": [ "species_10448927" ], "modifiers": [], "additional_components": [ "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515" ] }, "reaction_10448515": { "compartment": "compartment_70101", "id": "reaction_10448515", "reactome": "R-DME-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10448504", "catalyst" ] ], "additional_components": [ "FBgn0040918" ] }, "reaction_10448930": { "compartment": "compartment_70101", "id": "reaction_10448930", "reactome": "R-DME-429730", "name": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10448927" ], "products": [ "species_29372", "species_10448902" ], "modifiers": [ [ "species_10448927", "catalyst" ] ], "additional_components": [ "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515" ] }, "reaction_10474424": { "compartment": "compartment_261122", "id": "reaction_10474424", "reactome": "R-DME-5633040", "name": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474422" ], "products": [ "species_10474420", "species_10474409", "species_10474399" ], "modifiers": [], "additional_components": [ "P32865", "FBgn0260798", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "P91682", "phospho-smo", "P91682", "phospho-smo", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "FBgn0260798" ] }, "reaction_10497842": { "compartment": "compartment_876", "id": "reaction_10497842", "reactome": "R-DME-9632906", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438980", "species_10497827" ], "products": [ "species_10497840" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29420", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "P08646", "RAS85D", "species_29420" ] }, "reaction_10497830": { "compartment": "compartment_876", "id": "reaction_10497830", "reactome": "R-DME-9632858", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497822", "species_113592" ], "products": [ "species_29370", "species_10497827" ], "modifiers": [ [ "species_10497822", "catalyst" ] ], "additional_components": [ "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10497846": { "compartment": "compartment_7660", "id": "reaction_10497846", "reactome": "R-DME-9632910", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458634" ], "products": [ "species_10440931" ], "modifiers": [ [ "species_10497844", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "species_29438", "P08646", "RAS85D" ] }, "reaction_10497849": { "compartment": "compartment_876", "id": "reaction_10497849", "reactome": "R-DME-9632918", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497840" ], "products": [ "species_10497844" ], "modifiers": [], "additional_components": [ "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "P08646", "RAS85D", "species_29420", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "species_29438", "P08646", "RAS85D" ] }, "reaction_10449671": { "compartment": "compartment_172574", "id": "reaction_10449671", "reactome": "R-DME-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_445832", "species_1470067" ], "modifiers": [ [ "species_10449668", "catalyst" ] ], "additional_components": [ "species_1562550", "species_111793", "species_266099", "species_1562550", "species_266099", "species_111793", "FBgn0011672" ] }, "reaction_10449893": { "compartment": "compartment_7660", "id": "reaction_10449893", "reactome": "R-DME-442724", "name": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10449875", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0262866" ] }, "reaction_10497038": { "compartment": "compartment_7660", "id": "reaction_10497038", "reactome": "R-DME-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497030" ], "products": [ "species_10449875" ], "modifiers": [], "additional_components": [ "FBgn0262866", "FBgn0262866" ] }, "reaction_10450823": { "compartment": "compartment_5460", "id": "reaction_10450823", "reactome": "R-DME-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10450820", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "O77460", "FBgn0016687" ] }, "reaction_390087": { "compartment": "compartment_70101", "id": "reaction_390087", "reactome": "R-DME-390087", "name": "WTS binds to SAV", "reversible": "false", "notes": "The serine/threonine kinase, Warts (WTS), binds to the WW domain of the scaffolding protein Salvador (SAV). Hippo (HPO) kinase homodimer and WTS bind to different portions of SAV and the three proteins form a ternary complex.", "reactants": [ "species_451812", "species_390037" ], "products": [ "species_451836" ], "modifiers": [], "additional_components": [ "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO" ] }, "reaction_390145": { "compartment": "compartment_70101", "id": "reaction_390145", "reactome": "R-DME-390145", "name": "Phosphorylated HPO dimer phosphorylates SAV", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase homodimer phosphorylates the scaffolding Salvador (SAV) at unknown residues.", "reactants": [ "species_113592", "species_451829" ], "products": [ "species_29370", "species_451860" ], "modifiers": [ [ "species_451829", "catalyst" ] ], "additional_components": [ "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VCR6", "SAV", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q95RA8", "MATS" ] }, "reaction_390112": { "compartment": "compartment_70101", "id": "reaction_390112", "reactome": "R-DME-390112", "name": "Phosphorylated HPO dimer phosphorylates WTS", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase homodimer phosphorylates Warts (WTS) kinase at unknown residues.", "reactants": [ "species_113592", "species_451860" ], "products": [ "species_29370", "species_390172" ], "modifiers": [ [ "species_451860", "catalyst" ] ], "additional_components": [ "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VCR6", "SAV" ] }, "reaction_390035": { "compartment": "compartment_70101", "id": "reaction_390035", "reactome": "R-DME-390035", "name": "HPO dimer autophosphorylates", "reversible": "false", "notes": "The Hippo (HPO) serine/threonine kinase homodimer autophosphorylates on unknown residues and is activated. The scaffolding protein Salvador (SAV) appears to modestly increase the ability of HPO to autophosphorylate.", "reactants": [ "species_451805", "species_113592" ], "products": [ "species_29370", "species_451829" ], "modifiers": [ [ "species_451805", "catalyst" ] ], "additional_components": [ "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q8T0S6", "HPO", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q8T0S6", "HPO" ] }, "reaction_390124": { "compartment": "compartment_70101", "id": "reaction_390124", "reactome": "R-DME-390124", "name": "MATS binds to HPO dimer", "reversible": "false", "notes": "Mps one binder kinase activator-like 1 aka Mob as tumor suppressor protein 1 (MATS) associates with Hippo (HPO) kinase to form a complex.", "reactants": [ "species_390158", "species_451836" ], "products": [ "species_451805" ], "modifiers": [], "additional_components": [ "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q8T0S6", "HPO" ] }, "reaction_390025": { "compartment": "compartment_70101", "id": "reaction_390025", "reactome": "R-DME-390025", "name": "Phosphorylated WTS autophosphorylates", "reversible": "false", "notes": "Phosphorylated Warts (WTS) serine/threonine kinase autophosphorylates at unknown residues. WTS linase is now fully activated.", "reactants": [ "species_113592", "species_390134" ], "products": [ "species_29370", "species_390068" ], "modifiers": [ [ "species_390134", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390011": { "compartment": "compartment_70101", "id": "reaction_390011", "reactome": "R-DME-390011", "name": "HPO dimer binds to SAV", "reversible": "false", "notes": "Hippo (HPO) kinase homodimer associates with the scaffolding protein Salvador (SAV). The C-terminal SARAH (Salvador/Rassf/Hippo) domains of HPO homodimer bind to the N-terminal SARAH domian of SAV.", "reactants": [ "species_390185", "species_390014" ], "products": [ "species_451812" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q8T0S6", "HPO" ] }, "reaction_390154": { "compartment": "compartment_70101", "id": "reaction_390154", "reactome": "R-DME-390154", "name": "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS", "reversible": "false", "notes": "Mps one binder kinase activator-like 1 aka Mob as tumor suppressor protein 1 (MATS) is phosphorylated at unknown residues by the activated Hippo (HPO) serine/threonine kinase homodimer. The phosphorylation of MATS by HPO promotes its binding to Warts (WTS) kinase. MATS helps to activate WTS by relieving an autoinhibitory interaction between the N-terminal region and the C-terminal kinase region of WTS. It appears that MATS cannot simultaneously associate with HPO kinase homodimer and WTS in the same protein complex, so MATS dissociates from HPO homodimer and binds to phosphorylated WTS.", "reactants": [ "species_113592", "species_390172" ], "products": [ "species_29370", "species_390134" ], "modifiers": [ [ "species_390172", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_10476607": { "compartment": "compartment_70101", "id": "reaction_10476607", "reactome": "R-DME-5686073", "name": "GRB2-1:SOS1 binds p-3Y-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10476601" ], "products": [ "species_10476605" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10440940": { "compartment": "compartment_7660", "id": "reaction_10440940", "reactome": "R-DME-198756", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10440887" ], "products": [ "species_113582", "species_10440893" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "FBgn0020412", "FBgn0020412", "P40417", "FBgn0003256" ] }, "reaction_10440938": { "compartment": "compartment_7660", "id": "reaction_10440938", "reactome": "R-DME-198746", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10440901" ], "products": [ "species_113582", "species_10440913" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "FBgn0262866", "FBgn0262866", "P40417", "FBgn0003256" ] }, "reaction_10442249": { "compartment": "compartment_7660", "id": "reaction_10442249", "reactome": "R-DME-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10440935" ], "products": [ "species_113550", "species_10441236" ], "modifiers": [ [ "species_10442232", "catalyst" ], [ "species_10442247", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "X2JEB8", "FBgn0030976", "Q9VVW5", "FBgn0036844", "X2JEB8", "FBgn0030976", "Q7KMI3", "FBgn0027504", "Q7KRY6", "FBgn0027889" ] }, "reaction_10441253": { "compartment": "compartment_7660", "id": "reaction_10441253", "reactome": "R-DME-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10440935" ], "products": [ "species_113550", "species_10441236" ], "modifiers": [ [ "species_10441250", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q8IN89", "FBgn0042693" ] }, "reaction_10440896": { "compartment": "compartment_7660", "id": "reaction_10440896", "reactome": "R-DME-198669", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10440887" ], "products": [ "species_113582", "species_10440893" ], "modifiers": [ [ "species_10437359", "catalyst" ] ], "additional_components": [ "FBgn0020412", "FBgn0020412", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765" ] }, "reaction_10441211": { "compartment": "compartment_7660", "id": "reaction_10441211", "reactome": "R-DME-199895", "name": "RSK1/2/3 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10440913", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0262866" ] }, "reaction_10441226": { "compartment": "compartment_7660", "id": "reaction_10441226", "reactome": "R-DME-199935", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10440893", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0020412" ] }, "reaction_10441224": { "compartment": "compartment_7660", "id": "reaction_10441224", "reactome": "R-DME-199917", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10441221", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0013987" ] }, "reaction_10441219": { "compartment": "compartment_7660", "id": "reaction_10441219", "reactome": "R-DME-199910", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441213" ], "products": [ "species_113582", "species_10441216" ], "modifiers": [ [ "species_10440893", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0020412" ] }, "reaction_10440286": { "compartment": "compartment_70101", "id": "reaction_10440286", "reactome": "R-DME-193401", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10440156": { "compartment": "compartment_17951", "id": "reaction_10440156", "reactome": "R-DME-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_113575", "species_192342" ], "modifiers": [ [ "species_10440153", "catalyst" ] ], "additional_components": [ "species_113596", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628" ] }, "reaction_10440088": { "compartment": "compartment_70101", "id": "reaction_10440088", "reactome": "R-DME-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_192136", "species_29364" ], "products": [ "species_191980", "species_29366" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440119": { "compartment": "compartment_70101", "id": "reaction_10440119", "reactome": "R-DME-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440117": { "compartment": "compartment_70101", "id": "reaction_10440117", "reactome": "R-DME-192137", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10440115": { "compartment": "compartment_70101", "id": "reaction_10440115", "reactome": "R-DME-192097", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192114" ], "products": [ "species_70106", "species_192136", "species_73473" ], "modifiers": [ [ "species_10440112", "catalyst" ] ], "additional_components": [ "FBgn0036698" ] }, "reaction_10440275": { "compartment": "compartment_17951", "id": "reaction_10440275", "reactome": "R-DME-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_193442" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10440153", "catalyst" ] ], "additional_components": [ "species_113596", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628" ] }, "reaction_10440107": { "compartment": "compartment_70101", "id": "reaction_10440107", "reactome": "R-DME-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440299": { "compartment": "compartment_17951", "id": "reaction_10440299", "reactome": "R-DME-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440105": { "compartment": "compartment_17951", "id": "reaction_10440105", "reactome": "R-DME-192056", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192308" ], "products": [ "species_192316" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440297": { "compartment": "compartment_17951", "id": "reaction_10440297", "reactome": "R-DME-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440295": { "compartment": "compartment_17951", "id": "reaction_10440295", "reactome": "R-DME-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440292": { "compartment": "compartment_17951", "id": "reaction_10440292", "reactome": "R-DME-193452", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193429" ], "products": [ "species_193442" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440290": { "compartment": "compartment_70101", "id": "reaction_10440290", "reactome": "R-DME-193424", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193505" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10440097": { "compartment": "compartment_70101", "id": "reaction_10440097", "reactome": "R-DME-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440129": { "compartment": "compartment_17951", "id": "reaction_10440129", "reactome": "R-DME-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192342" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440288": { "compartment": "compartment_70101", "id": "reaction_10440288", "reactome": "R-DME-193407", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_193505", "species_76194" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10447126": { "compartment": "compartment_70101", "id": "reaction_10447126", "reactome": "R-DME-399944", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447104", "species_113592", "species_10447082" ], "products": [ "species_10447123", "species_29370" ], "modifiers": [ [ "species_10447104", "catalyst" ] ], "additional_components": [ "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259" ] }, "reaction_10447158": { "compartment": "compartment_70101", "id": "reaction_10447158", "reactome": "R-DME-399951", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447123", "species_113592" ], "products": [ "species_10447155", "species_29370" ], "modifiers": [ [ "species_10440540", "catalyst" ] ], "additional_components": [ "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P83101", "FBgn0046332", "P18431", "sgg" ] }, "reaction_10447140": { "compartment": "compartment_70101", "id": "reaction_10447140", "reactome": "R-DME-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447082", "species_10447002" ], "products": [ "species_10447137", "species_29370" ], "modifiers": [ [ "species_10442644", "catalyst" ] ], "additional_components": [ "Q8IPQ2", "FBgn0023023", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "Q8IPQ2", "FBgn0023023", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "FBgn0000723" ] }, "reaction_10447319": { "compartment": "compartment_70101", "id": "reaction_10447319", "reactome": "R-DME-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447312", "species_10442527" ], "products": [ "species_10447314" ], "modifiers": [], "additional_components": [ "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731", "FBgn0023172", "A1ZAN6", "FBgn0023172", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731" ] }, "reaction_10444630": { "compartment": "compartment_70101", "id": "reaction_10444630", "reactome": "R-DME-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10444615", "species_10444599" ], "products": [ "species_10444627", "species_29370" ], "modifiers": [ [ "species_10444615", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740" ] }, "reaction_10447317": { "compartment": "compartment_70101", "id": "reaction_10447317", "reactome": "R-DME-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447308" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10447314", "catalyst" ] ], "additional_components": [ "species_29420", "P48148", "Rho1", "P48148", "Rho1", "species_29438", "A1ZAN6", "FBgn0023172", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731" ] }, "reaction_10447651": { "compartment": "compartment_70101", "id": "reaction_10447651", "reactome": "R-DME-419049", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604", "species_10434906" ], "products": [ "species_10447647" ], "modifiers": [ [ "species_10447649", "inhibitor" ] ], "additional_components": [ "FBgn0026181", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181", "Q9VXE3", "FBgn0026181" ] }, "reaction_10498524": { "compartment": "compartment_70101", "id": "reaction_10498524", "reactome": "R-DME-9680443", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9686558", "species_10441604" ], "products": [ "species_10447649" ], "modifiers": [], "additional_components": [ "FBgn0026181", "Q9VXE3", "FBgn0026181" ] }, "reaction_10447670": { "compartment": "compartment_70101", "id": "reaction_10447670", "reactome": "R-DME-419645", "name": "Dimerization of LIMK1 by Hsp90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441846", "species_10447166" ], "products": [ "species_10447660" ], "modifiers": [], "additional_components": [ "FBgn0001233", "FBgn0283712", "Q8IR79", "FBgn0283712", "P02828", "FBgn0001233" ] }, "reaction_10447668": { "compartment": "compartment_70101", "id": "reaction_10447668", "reactome": "R-DME-419644", "name": "Transphosphorylation of pLIMK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447660" ], "products": [ "species_10447665", "species_29370", "species_10441846" ], "modifiers": [ [ "species_10447660", "catalyst" ] ], "additional_components": [ "Q8IR79", "FBgn0283712", "P02828", "FBgn0001233", "Q8IR79", "FBgn0283712", "FBgn0001233", "Q8IR79", "FBgn0283712", "P02828", "FBgn0001233" ] }, "reaction_10447074": { "compartment": "compartment_70101", "id": "reaction_10447074", "reactome": "R-DME-399939", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447006" ], "products": [ "species_29370", "species_10447071" ], "modifiers": [ [ "species_10447006", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10447169": { "compartment": "compartment_70101", "id": "reaction_10447169", "reactome": "R-DME-399952", "name": "Phosphorylation of LIMK-1 by PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447163" ], "products": [ "species_29370", "species_10447166" ], "modifiers": [ [ "species_10447071", "catalyst" ] ], "additional_components": [ "FBgn0283712", "FBgn0283712", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10447008": { "compartment": "compartment_70101", "id": "reaction_10447008", "reactome": "R-DME-399930", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446523", "species_10447004" ], "products": [ "species_10447006", "species_10446511" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698" ] }, "reaction_10447047": { "compartment": "compartment_876", "id": "reaction_10447047", "reactome": "R-DME-399933", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447041", "species_10446972" ], "products": [ "species_10447045", "species_10447037" ], "modifiers": [], "additional_components": [ "A8JQT5", "FBgn0265082", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P00528", "FBgn0262733", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P00528", "FBgn0262733", "FBgn0265082" ] }, "reaction_10447058": { "compartment": "compartment_70101", "id": "reaction_10447058", "reactome": "R-DME-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447037", "species_10447054" ], "products": [ "species_10447056", "species_10444276" ], "modifiers": [], "additional_components": [ "FBgn0265082", "Q0E8Y1", "FBgn0034789", "Q9VSL8", "FBgn0260442", "A8JQT5", "FBgn0265082", "Q0E8Y1", "FBgn0034789", "FBgn0260442" ] }, "reaction_10449663": { "compartment": "compartment_876", "id": "reaction_10449663", "reactome": "R-DME-434989", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449651", "species_10449659" ], "products": [ "species_10449661" ], "modifiers": [], "additional_components": [ "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740" ] }, "reaction_10447402": { "compartment": "compartment_984", "id": "reaction_10447402", "reactome": "R-DME-416683", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447392", "species_10447398" ], "products": [ "species_10447400" ], "modifiers": [], "additional_components": [ "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259" ] }, "reaction_10447414": { "compartment": "compartment_876", "id": "reaction_10447414", "reactome": "R-DME-416690", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447410", "species_10447398" ], "products": [ "species_10447412" ], "modifiers": [], "additional_components": [ "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059" ] }, "reaction_10447429": { "compartment": "compartment_876", "id": "reaction_10447429", "reactome": "R-DME-416698", "name": "SEMA5A binds to PLXNB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447425", "species_10447419" ], "products": [ "species_10447427" ], "modifiers": [], "additional_components": [ "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "FBgn0284221", "Q9VTT0", "FBgn0284221", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741" ] }, "reaction_10446800": { "compartment": "compartment_70101", "id": "reaction_10446800", "reactome": "R-DME-392054", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10446797", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "P00528", "FBgn0262733", "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617" ] }, "reaction_10444970": { "compartment": "compartment_984", "id": "reaction_10444970", "reactome": "R-DME-375160", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114570", "species_10444966" ], "products": [ "species_10444968" ], "modifiers": [], "additional_components": [ "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617", "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617", "species_113592" ] }, "reaction_10445181": { "compartment": "compartment_876", "id": "reaction_10445181", "reactome": "R-DME-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445177" ], "products": [ "species_10445179" ], "modifiers": [], "additional_components": [ "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046" ] }, "reaction_10445193": { "compartment": "compartment_70101", "id": "reaction_10445193", "reactome": "R-DME-376123", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445189", "species_10445167" ], "products": [ "species_10445191" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10451543": { "compartment": "compartment_70101", "id": "reaction_10451543", "reactome": "R-DME-451347", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_10437429", "species_29370" ], "modifiers": [ [ "species_10445191", "catalyst" ] ], "additional_components": [ "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10451574": { "compartment": "compartment_70101", "id": "reaction_10451574", "reactome": "R-DME-451366", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451571", "species_113592" ], "products": [ "species_29370", "species_10439434" ], "modifiers": [ [ "species_10445191", "catalyst" ] ], "additional_components": [ "species_29926", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "species_29926", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10444747": { "compartment": "compartment_70101", "id": "reaction_10444747", "reactome": "R-DME-374662", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444743", "species_179856" ], "products": [ "species_10444745" ], "modifiers": [], "additional_components": [ "FBgn0011661", "species_179856", "P46150", "FBgn0011661" ] }, "reaction_10444759": { "compartment": "compartment_70101", "id": "reaction_10444759", "reactome": "R-DME-374664", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10444745" ], "products": [ "species_10444752", "species_29370" ], "modifiers": [ [ "species_10441896", "catalyst" ] ], "additional_components": [ "species_179856", "P46150", "FBgn0011661", "P46150", "FBgn0011661", "species_179856", "FBgn0259680" ] }, "reaction_10444447": { "compartment": "compartment_876", "id": "reaction_10444447", "reactome": "R-DME-373707", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444421", "species_10444443" ], "products": [ "species_10444445" ], "modifiers": [], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444795": { "compartment": "compartment_70101", "id": "reaction_10444795", "reactome": "R-DME-374701", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10444792" ], "products": [ "species_29370", "species_10444508" ], "modifiers": [ [ "species_10444792", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444449": { "compartment": "compartment_984", "id": "reaction_10444449", "reactome": "R-DME-373711", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444421", "species_10444441" ], "products": [ "species_10444443" ], "modifiers": [], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "FBgn0015773", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444512": { "compartment": "compartment_70101", "id": "reaction_10444512", "reactome": "R-DME-373716", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444486", "species_10444508" ], "products": [ "species_10444510" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "Q9VPU1", "dock" ] }, "reaction_10453702": { "compartment": "compartment_876", "id": "reaction_10453702", "reactome": "R-DME-593685", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10453698", "species_10453691" ], "products": [ "species_10453700" ], "modifiers": [], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q95TU8", "FBgn0034013", "FBgn0261800", "P11046", "FBgn0261800", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q95TU8", "FBgn0034013" ] }, "reaction_10444756": { "compartment": "compartment_876", "id": "reaction_10444756", "reactome": "R-DME-374663", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444752", "species_10444421" ], "products": [ "species_10444754" ], "modifiers": [], "additional_components": [ "P46150", "FBgn0011661", "species_179856", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "P46150", "FBgn0011661", "species_179856" ] }, "reaction_10444786": { "compartment": "compartment_70101", "id": "reaction_10444786", "reactome": "R-DME-374667", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444443", "species_10444782" ], "products": [ "species_10444784" ], "modifiers": [], "additional_components": [ "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444768": { "compartment": "compartment_70101", "id": "reaction_10444768", "reactome": "R-DME-374665", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444443", "species_10444764" ], "products": [ "species_10444766" ], "modifiers": [], "additional_components": [ "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "FBgn0003410", "P21461", "FBgn0003410", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10496097": { "compartment": "compartment_984", "id": "reaction_10496097", "reactome": "R-DME-9010815", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496093", "species_2299699" ], "products": [ "species_10496095" ], "modifiers": [], "additional_components": [ "Q9VUN0", "FBgn0036494", "P24014", "sli", "species_2299699", "Q9VUN0", "FBgn0036494", "P24014", "sli" ] }, "reaction_10448744": { "compartment": "compartment_70101", "id": "reaction_10448744", "reactome": "R-DME-428888", "name": "Phosphorylation of ROBO1 by ABL kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445201", "species_113592" ], "products": [ "species_29370", "species_10448741" ], "modifiers": [ [ "species_10445201", "catalyst" ] ], "additional_components": [ "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9W213", "FBgn0005631", "M9PC46", "FBgn0002543", "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631" ] }, "reaction_10445203": { "compartment": "compartment_70101", "id": "reaction_10445203", "reactome": "R-DME-376141", "name": "Interaction of ABL with ROBO1:SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442417", "species_10445197" ], "products": [ "species_10445201" ], "modifiers": [], "additional_components": [ "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631" ] }, "reaction_10448598": { "compartment": "compartment_876", "id": "reaction_10448598", "reactome": "R-DME-428518", "name": "Glypican-1 (GPC1) binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448594", "species_10448587" ], "products": [ "species_10448596" ], "modifiers": [], "additional_components": [ "Q9VUG1", "FBgn0041604", "CHEBI:17421", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9VUG1", "FBgn0041604", "CHEBI:17421" ] }, "reaction_10496540": { "compartment": "compartment_984", "id": "reaction_10496540", "reactome": "R-DME-9014812", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496536", "species_2299699" ], "products": [ "species_10496538" ], "modifiers": [], "additional_components": [ "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "species_2299699", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog" ] }, "reaction_10442419": { "compartment": "compartment_876", "id": "reaction_10442419", "reactome": "R-DME-204364", "name": "ROBO1 binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442404", "species_10442415" ], "products": [ "species_10442417" ], "modifiers": [], "additional_components": [ "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631" ] }, "reaction_10448585": { "compartment": "compartment_876", "id": "reaction_10448585", "reactome": "R-DME-428510", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448581", "species_10448573" ], "products": [ "species_10448583" ], "modifiers": [], "additional_components": [ "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog" ] }, "reaction_10469295": { "compartment": "compartment_876", "id": "reaction_10469295", "reactome": "R-DME-3928591", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469291", "species_10469293" ], "products": [ "species_10469226" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469436": { "compartment": "compartment_70101", "id": "reaction_10469436", "reactome": "R-DME-3928641", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469389", "species_10446511" ], "products": [ "species_10469391" ], "modifiers": [], "additional_components": [ "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469434": { "compartment": "compartment_70101", "id": "reaction_10469434", "reactome": "R-DME-3928640", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10450286" ], "products": [ "species_10450386", "species_29370" ], "modifiers": [ [ "species_10469397", "catalyst" ] ], "additional_components": [ "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10469641": { "compartment": "compartment_70101", "id": "reaction_10469641", "reactome": "R-DME-4093329", "name": "EFNBs bind SDCBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469222", "species_10444571" ], "products": [ "species_10469639" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "FBgn0051342", "A8JQY9", "FBgn0051342", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469368": { "compartment": "compartment_70101", "id": "reaction_10469368", "reactome": "R-DME-3928615", "name": "EFNBs bind SFKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444516", "species_10469222" ], "products": [ "species_10469366" ], "modifiers": [], "additional_components": [ "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733" ] }, "reaction_10469400": { "compartment": "compartment_70101", "id": "reaction_10469400", "reactome": "R-DME-3928625", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469391" ], "products": [ "species_29370", "species_10469397" ], "modifiers": [ [ "species_10469391", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469431": { "compartment": "compartment_70101", "id": "reaction_10469431", "reactome": "R-DME-3928639", "name": "p-EFNB binds GRB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444514", "species_10469352" ], "products": [ "species_10469354" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock" ] }, "reaction_10469429": { "compartment": "compartment_876", "id": "reaction_10469429", "reactome": "R-DME-3928633", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442464", "species_29438", "species_10469387" ], "products": [ "species_114549", "species_10469389" ], "modifiers": [ [ "species_10469387", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539" ] }, "reaction_10469364": { "compartment": "compartment_70101", "id": "reaction_10469364", "reactome": "R-DME-3928614", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469360", "species_10469354" ], "products": [ "species_10469362" ], "modifiers": [], "additional_components": [ "FBgn0033539", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539" ] }, "reaction_10469426": { "compartment": "compartment_70101", "id": "reaction_10469426", "reactome": "R-DME-3928631", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469362", "species_10439144" ], "products": [ "species_10469387" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "FBgn0015803", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539" ] }, "reaction_10469457": { "compartment": "compartment_876", "id": "reaction_10469457", "reactome": "R-DME-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10469454", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VVC6", "FBgn0261547" ] }, "reaction_10469385": { "compartment": "compartment_876", "id": "reaction_10469385", "reactome": "R-DME-3928624", "name": "EPHBs bind EFNBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469206", "species_10469212" ], "products": [ "species_10469222" ], "modifiers": [], "additional_components": [ "FBgn0040324", "FBgn0025936", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469320": { "compartment": "compartment_876", "id": "reaction_10469320", "reactome": "R-DME-3928597", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469293" ], "products": [ "species_10469291" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469447": { "compartment": "compartment_876", "id": "reaction_10469447", "reactome": "R-DME-3928646", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469184", "species_10469171" ], "products": [ "species_10469202" ], "modifiers": [], "additional_components": [ "FBgn0025936", "FBgn0040324", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936" ] }, "reaction_10469285": { "compartment": "compartment_70101", "id": "reaction_10469285", "reactome": "R-DME-3928578", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469226" ], "products": [ "species_10469282", "species_29370" ], "modifiers": [ [ "species_10469226", "catalyst" ] ], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469657": { "compartment": "compartment_876", "id": "reaction_10469657", "reactome": "R-DME-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10469418", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "P91621", "FBgn0085447", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382" ] }, "reaction_10469304": { "compartment": "compartment_70101", "id": "reaction_10469304", "reactome": "R-DME-3928592", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10469301", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "M9PBE1", "FBgn0032796" ] }, "reaction_10469654": { "compartment": "compartment_876", "id": "reaction_10469654", "reactome": "R-DME-4093332", "name": "p-EPHB phosphorylates SDC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10461274" ], "products": [ "species_10469651", "species_29370" ], "modifiers": [ [ "species_10469280", "catalyst" ] ], "additional_components": [ "FBgn0010415", "FBgn0010415", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936" ] }, "reaction_10469647": { "compartment": "compartment_70101", "id": "reaction_10469647", "reactome": "R-DME-4093331", "name": "Ras:GTP binds p120-RasGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_206703", "species_10469643" ], "products": [ "species_10469645" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29438", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "P08646", "RAS85D", "species_29438" ] }, "reaction_10469166": { "compartment": "compartment_876", "id": "reaction_10469166", "reactome": "R-DME-3928576", "name": "RHOA:GTP binds ROCK, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604", "species_10434906" ], "products": [ "species_10447647" ], "modifiers": [], "additional_components": [ "FBgn0026181", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181" ] }, "reaction_10469421": { "compartment": "compartment_70101", "id": "reaction_10469421", "reactome": "R-DME-3928627", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469413", "species_113592" ], "products": [ "species_29370", "species_10469418" ], "modifiers": [ [ "species_10469413", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P91621", "FBgn0085447", "P91621", "FBgn0085447", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P91621", "FBgn0085447" ] }, "reaction_10469322": { "compartment": "compartment_876", "id": "reaction_10469322", "reactome": "R-DME-3928601", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469312", "species_179856" ], "products": [ "species_10469314" ], "modifiers": [], "additional_components": [ "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341", "species_179856", "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10469383": { "compartment": "compartment_70101", "id": "reaction_10469383", "reactome": "R-DME-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469374" ], "products": [ "species_10469380", "species_29370" ], "modifiers": [ [ "species_10469374", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469318": { "compartment": "compartment_876", "id": "reaction_10469318", "reactome": "R-DME-3928595", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469314", "species_10461790", "species_10442127" ], "products": [ "species_10469316" ], "modifiers": [], "additional_components": [ "species_179856", "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "species_179856", "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10469445": { "compartment": "compartment_70101", "id": "reaction_10469445", "reactome": "R-DME-3928645", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442480", "species_10469411" ], "products": [ "species_10469413" ], "modifiers": [], "additional_components": [ "FBgn0085447", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P91621", "FBgn0085447" ] }, "reaction_10469668": { "compartment": "compartment_876", "id": "reaction_10469668", "reactome": "R-DME-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469651" ], "products": [ "species_10469666" ], "modifiers": [], "additional_components": [ "FBgn0010415", "P49415", "FBgn0010415" ] }, "reaction_10469376": { "compartment": "compartment_876", "id": "reaction_10469376", "reactome": "R-DME-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_10442466" ], "products": [ "species_10469374" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469664": { "compartment": "compartment_876", "id": "reaction_10469664", "reactome": "R-DME-4093339", "name": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10469645" ], "products": [ "species_29372", "species_10469661" ], "modifiers": [ [ "species_10469645", "catalyst" ] ], "additional_components": [ "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "P08646", "RAS85D", "species_29438", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29420", "P08646", "RAS85D", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "P08646", "RAS85D", "species_29438" ] }, "reaction_10469503": { "compartment": "compartment_876", "id": "reaction_10469503", "reactome": "R-DME-3928656", "name": "gamma-secretase cleaves EPHB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469481" ], "products": [ "species_10469491", "species_10469501" ], "modifiers": [ [ "species_10458502", "catalyst" ] ], "additional_components": [ "FBgn0025936", "FBgn0025936", "FBgn0025936", "Q9VQG2", "FBgn0031458", "Q86BE9", "FBgn0053198", "O02194", "FBgn0284421", "Q9VC27", "FBgn0039234" ] }, "reaction_10469516": { "compartment": "compartment_876", "id": "reaction_10469516", "reactome": "R-DME-3928657", "name": "MMP2,9 cleave EPHB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469222" ], "products": [ "species_10469505", "species_10469206", "species_10469481" ], "modifiers": [ [ "species_10459272", "catalyst" ] ], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "FBgn0025936", "FBgn0040324", "FBgn0025936", "FBgn0035049" ] }, "reaction_10469479": { "compartment": "compartment_876", "id": "reaction_10469479", "reactome": "R-DME-3928654", "name": "Clathrin internalises EPH:EFN complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469475", "species_10439846", "species_10469222", "species_10469463", "species_10439790" ], "products": [ "species_10469477" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "FBgn0003392", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P27619", "FBgn0003392", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10469333": { "compartment": "compartment_876", "id": "reaction_10469333", "reactome": "R-DME-3928607", "name": "p-EPHs bind VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442473", "species_10469324" ], "products": [ "species_10469326" ], "modifiers": [], "additional_components": [ "FBgn0040068", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9NHV9", "FBgn0040068" ] }, "reaction_10469637": { "compartment": "compartment_70101", "id": "reaction_10469637", "reactome": "R-DME-4093327", "name": "EPHA binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442480", "species_10469438" ], "products": [ "species_10469440" ], "modifiers": [], "additional_components": [ "FBgn0085447", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "P91621", "FBgn0085447" ] }, "reaction_10469331": { "compartment": "compartment_876", "id": "reaction_10469331", "reactome": "R-DME-3928604", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469326" ], "products": [ "species_10469328", "species_29370" ], "modifiers": [ [ "species_10469326", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9NHV9", "FBgn0040068", "Q9NHV9", "FBgn0040068", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9NHV9", "FBgn0040068" ] }, "reaction_10469443": { "compartment": "compartment_876", "id": "reaction_10469443", "reactome": "R-DME-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10469440", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "P91621", "FBgn0085447" ] }, "reaction_10450221": { "compartment": "compartment_70101", "id": "reaction_10450221", "reactome": "R-DME-445079", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446836", "species_113592", "species_10433787" ], "products": [ "species_29370", "species_10450218" ], "modifiers": [ [ "species_10433787", "catalyst" ] ], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "FBgn0003256", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "P40417", "FBgn0003256", "Q8T390", "FBgn0038659", "FBgn0003256" ] }, "reaction_10453467": { "compartment": "compartment_876", "id": "reaction_10453467", "reactome": "R-DME-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438817", "species_10453462" ], "products": [ "species_29372", "species_29420", "species_10446836" ], "modifiers": [ [ "species_10439850", "catalyst" ] ], "additional_components": [ "FBgn0038659", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659" ] }, "reaction_10446838": { "compartment": "compartment_17940", "id": "reaction_10446838", "reactome": "R-DME-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446836" ], "products": [ "species_10446836" ], "modifiers": [], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659" ] }, "reaction_10444575": { "compartment": "compartment_70101", "id": "reaction_10444575", "reactome": "R-DME-373738", "name": "Neurofascin interacts with syntenin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444571", "species_10444543" ], "products": [ "species_10444573" ], "modifiers": [], "additional_components": [ "FBgn0051342", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "A8JQY9", "FBgn0051342" ] }, "reaction_10444553": { "compartment": "compartment_876", "id": "reaction_10444553", "reactome": "R-DME-373730", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444549", "species_10444543" ], "products": [ "species_10444551" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388" ] }, "reaction_10449908": { "compartment": "compartment_876", "id": "reaction_10449908", "reactome": "R-DME-443774", "name": "Trans-homodimerization of Neurofascin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449904", "species_10444543" ], "products": [ "species_10449906" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q0KIE7", "FBgn0011747", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q0KIE7", "FBgn0011747" ] }, "reaction_10450094": { "compartment": "compartment_70101", "id": "reaction_10450094", "reactome": "R-DME-445064", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10449774", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "FBgn0040068" ] }, "reaction_10450214": { "compartment": "compartment_70101", "id": "reaction_10450214", "reactome": "R-DME-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_351067", "species_113592" ], "products": [ "species_10450211", "species_29370", "species_10446511" ], "modifiers": [ [ "species_10446511", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698", "FBgn0267698" ] }, "reaction_10433782": { "compartment": "compartment_70101", "id": "reaction_10433782", "reactome": "R-DME-109860", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10433757" ], "products": [ "species_29370", "species_10433773" ], "modifiers": [ [ "species_10433757", "catalyst" ], [ "species_10433778", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10433792": { "compartment": "compartment_70101", "id": "reaction_10433792", "reactome": "R-DME-109862", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433765", "species_113592" ], "products": [ "species_29370", "species_10433789" ], "modifiers": [ [ "species_10433765", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10497559": { "compartment": "compartment_12045", "id": "reaction_10497559", "reactome": "R-DME-9614271", "name": "Autocleavage of ADGRG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497538" ], "products": [ "species_10497556" ], "modifiers": [ [ "species_10497538", "catalyst" ] ], "additional_components": [ "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818", "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818", "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818" ] }, "reaction_10497561": { "compartment": "compartment_876", "id": "reaction_10497561", "reactome": "R-DME-9614273", "name": "ADGRG heterodimer translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497556" ], "products": [ "species_10497556" ], "modifiers": [], "additional_components": [ "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818", "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818" ] }, "reaction_10437846": { "compartment": "compartment_70101", "id": "reaction_10437846", "reactome": "R-DME-170847", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437831", "species_10437838" ], "products": [ "species_10437844" ], "modifiers": [], "additional_components": [ "FBgn0011655", "FBgn0025800", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10437955": { "compartment": "compartment_70101", "id": "reaction_10437955", "reactome": "R-DME-173488", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437844" ], "products": [ "species_10437946" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10459921": { "compartment": "compartment_7660", "id": "reaction_10459921", "reactome": "R-DME-1535903", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1535904", "species_10437946", "species_10441099" ], "products": [ "species_10459919" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q95V55", "foxo", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10443101": { "compartment": "compartment_7660", "id": "reaction_10443101", "reactome": "R-DME-211164", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441097" ], "products": [ "species_113582", "species_10441108" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10443105": { "compartment": "compartment_7660", "id": "reaction_10443105", "reactome": "R-DME-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441108" ], "products": [ "species_10443103" ], "modifiers": [], "additional_components": [] }, "reaction_10486931": { "compartment": "compartment_70101", "id": "reaction_10486931", "reactome": "R-DME-6810843", "name": "Envoplakin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486927", "species_10486925" ], "products": [ "species_10486929" ], "modifiers": [], "additional_components": [ "FBgn0013733", "FBgn0013733", "A1Z9J3", "FBgn0013733" ] }, "reaction_10480300": { "compartment": "compartment_984", "id": "reaction_10480300", "reactome": "R-DME-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10480297", "catalyst" ] ], "additional_components": [ "Q9VPE9", "FBgn0036996", "Q9VG47", "FBgn0038069", "Q9VG46", "FBgn0038070", "Q9VBK6", "FBgn0051091", "Q9V9N3", "FBgn0032981", "Q8IMS3", "FBgn0051091", "Q59E63", "FBgn0034990", "Q9VQQ5", "FBgn0031533", "Q4V6L4", "FBgn0033999", "Q0KI77", "FBgn0038067", "Q9VKT8", "FBgn0032265", "O46108", "FBgn0023495", "Q9VKT7", "FBgn0032266", "O46107", "FBgn0023496", "Q9VKT2", "FBgn0032271", "M9PCU5", "FBgn0032264", "Q9VKT1", "FBgn0051872", "E2QCS7", "FBgn0265264", "Q9VKS9", "FBgn0043825", "Q9VKS5", "FBgn0051871", "Q9VKR5", "FBgn0024740", "Q9VG50", "FBgn0042207", "Q9VG48", "FBgn0038068" ] }, "reaction_10487309": { "compartment": "compartment_876", "id": "reaction_10487309", "reactome": "R-DME-6814187", "name": "EVL:PPL heterodimer binds the inner surface of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10486929" ], "products": [ "species_10486933" ], "modifiers": [], "additional_components": [ "A1Z9J3", "FBgn0013733", "A1Z9J3", "FBgn0013733" ] }, "reaction_10487326": { "compartment": "compartment_70101", "id": "reaction_10487326", "reactome": "R-DME-6814374", "name": "Kazrin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486927", "species_10487322" ], "products": [ "species_10487324" ], "modifiers": [], "additional_components": [ "FBgn0013733", "FBgn0034720", "A8DYM0", "FBgn0034720", "A1Z9J3", "FBgn0013733" ] }, "reaction_10444879": { "compartment": "compartment_876", "id": "reaction_10444879", "reactome": "R-DME-375138", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444869", "species_10444875" ], "products": [ "species_10444877" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388" ] }, "reaction_10450726": { "compartment": "compartment_876", "id": "reaction_10450726", "reactome": "R-DME-448958", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450724" ], "products": [ "species_10450672", "species_10450722" ], "modifiers": [], "additional_components": [ "P00522", "Abl", "Q9VZJ4", "FBgn0035488", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "species_29438", "P40793", "FBgn0010341", "Q9GQF1", "FBgn0024187", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P00522", "Abl", "Q9VZJ4", "FBgn0035488", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "species_29438", "P40793", "FBgn0010341", "Q9GQF1", "FBgn0024187" ] }, "reaction_10450755": { "compartment": "compartment_7660", "id": "reaction_10450755", "reactome": "R-DME-448963", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450683", "species_10450751" ], "products": [ "species_10450753" ], "modifiers": [], "additional_components": [ "P40791", "FBgn0011656", "P11420", "FBgn0267821", "P22816", "FBgn0002922", "P11420", "FBgn0267821", "P22816", "FBgn0002922", "P40791", "FBgn0011656" ] }, "reaction_10444914": { "compartment": "compartment_876", "id": "reaction_10444914", "reactome": "R-DME-375140", "name": "CDO binds promyogenic cadherins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444877", "species_10444910" ], "products": [ "species_10444912" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388" ] }, "reaction_10450688": { "compartment": "compartment_7660", "id": "reaction_10450688", "reactome": "R-DME-448955", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450672", "species_10450656", "species_29358" ], "products": [ "species_113582", "species_10450685" ], "modifiers": [ [ "species_10450672", "catalyst" ] ], "additional_components": [ "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "FBgn0011656", "P40791", "FBgn0011656", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846" ] }, "reaction_10445986": { "compartment": "compartment_7660", "id": "reaction_10445986", "reactome": "R-DME-381262", "name": "Formation of PPARG:RXRA heterodimer (ARF6 complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440428", "species_10445293" ], "products": [ "species_10445984" ], "modifiers": [], "additional_components": [ "FBgn0003964", "FBgn0000568", "P13055", "FBgn0000568", "P20153", "FBgn0003964" ] }, "reaction_10497719": { "compartment": "compartment_7660", "id": "reaction_10497719", "reactome": "R-DME-9624112", "name": "CEBPA binds CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432391", "species_10497715" ], "products": [ "species_10497717" ], "modifiers": [], "additional_components": [ "FBgn0016131", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q7K306", "FBgn0016131" ] }, "reaction_10497723": { "compartment": "compartment_7660", "id": "reaction_10497723", "reactome": "R-DME-9624120", "name": "CEBPA binds CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427334", "species_10497715" ], "products": [ "species_10497721" ], "modifiers": [], "additional_components": [ "FBgn0004107", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "P23573", "FBgn0004107" ] }, "reaction_10497614": { "compartment": "compartment_7660", "id": "reaction_10497614", "reactome": "R-DME-9617067", "name": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497606", "species_5334804" ], "products": [ "species_10497612" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "species_5334816", "P13055", "FBgn0000568" ] }, "reaction_10430843": { "compartment": "compartment_70101", "id": "reaction_10430843", "reactome": "R-DME-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430839", "species_10430461" ], "products": [ "species_10430463" ], "modifiers": [], "additional_components": [ "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136" ] }, "reaction_10430537": { "compartment": "compartment_70101", "id": "reaction_10430537", "reactome": "R-DME-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72393", "species_10430459" ], "products": [ "species_10430461" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438" ] }, "reaction_10430535": { "compartment": "compartment_70101", "id": "reaction_10430535", "reactome": "R-DME-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10430457" ], "products": [ "species_10430459" ], "modifiers": [], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438" ] }, "reaction_10465097": { "compartment": "compartment_70101", "id": "reaction_10465097", "reactome": "R-DME-2161779", "name": "LXA4 is oxidised to 15k-LXA4 by HPGD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161759", "species_29360" ], "products": [ "species_70106", "species_2142761", "species_73473" ], "modifiers": [ [ "species_10465094", "catalyst" ] ], "additional_components": [ "Q9I7R3", "FBgn0042137" ] }, "reaction_10496834": { "compartment": "compartment_70101", "id": "reaction_10496834", "reactome": "R-DME-9018868", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020583", "species_29450" ], "products": [ "species_29356", "species_9020474", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496829": { "compartment": "compartment_70101", "id": "reaction_10496829", "reactome": "R-DME-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496973": { "compartment": "compartment_70101", "id": "reaction_10496973", "reactome": "R-DME-9023968", "name": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9022660", "species_29360" ], "products": [ "species_9023963", "species_73473" ], "modifiers": [ [ "species_10465094", "catalyst" ] ], "additional_components": [ "Q9I7R3", "FBgn0042137" ] }, "reaction_10496836": { "compartment": "compartment_70101", "id": "reaction_10496836", "reactome": "R-DME-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9023708" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496838": { "compartment": "compartment_70101", "id": "reaction_10496838", "reactome": "R-DME-9018895", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023653", "species_29450" ], "products": [ "species_29356", "species_9023651", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496848": { "compartment": "compartment_70101", "id": "reaction_10496848", "reactome": "R-DME-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:138615", "CHEBI:138616", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496850": { "compartment": "compartment_70101", "id": "reaction_10496850", "reactome": "R-DME-9020271", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024522" ], "products": [ "species_29356", "species_9024463", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496840": { "compartment": "compartment_70101", "id": "reaction_10496840", "reactome": "R-DME-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024602" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10497011": { "compartment": "compartment_70101", "id": "reaction_10497011", "reactome": "R-DME-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10432773", "catalyst" ] ], "additional_components": [ "Q95078", "FBgn0010383", "Q9VWR5", "FBgn0004959" ] }, "reaction_10496852": { "compartment": "compartment_70101", "id": "reaction_10496852", "reactome": "R-DME-9020273", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024012" ], "products": [ "species_29356", "species_9024815", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496842": { "compartment": "compartment_70101", "id": "reaction_10496842", "reactome": "R-DME-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024781" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10497004": { "compartment": "compartment_70101", "id": "reaction_10497004", "reactome": "R-DME-9024766", "name": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024764", "species_29360" ], "products": [ "species_9024799", "species_73473" ], "modifiers": [ [ "species_10465094", "catalyst" ] ], "additional_components": [ "CHEBI:132797", "CHEBI:132800", "Q9I7R3", "FBgn0042137" ] }, "reaction_10496846": { "compartment": "compartment_70101", "id": "reaction_10496846", "reactome": "R-DME-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "species_9024764", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496844": { "compartment": "compartment_70101", "id": "reaction_10496844", "reactome": "R-DME-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024893" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10497006": { "compartment": "compartment_70101", "id": "reaction_10497006", "reactome": "R-DME-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10450926": { "compartment": "compartment_70101", "id": "reaction_10450926", "reactome": "R-DME-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437429" ], "products": [ "species_10437365" ], "modifiers": [], "additional_components": [] }, "reaction_10437443": { "compartment": "compartment_70101", "id": "reaction_10437443", "reactome": "R-DME-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_10437429", "species_29370" ], "modifiers": [ [ "species_10437440", "catalyst" ] ], "additional_components": [ "FBgn0024326" ] }, "reaction_10450893": { "compartment": "compartment_70101", "id": "reaction_10450893", "reactome": "R-DME-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450883" ], "products": [ "species_10450889" ], "modifiers": [], "additional_components": [ "FBgn0261524", "FBgn0261524" ] }, "reaction_10450918": { "compartment": "compartment_7660", "id": "reaction_10450918", "reactome": "R-DME-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10450915" ], "products": [ "species_113582", "species_10450840" ], "modifiers": [ [ "species_10450889", "catalyst" ] ], "additional_components": [ "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "FBgn0261524" ] }, "reaction_10450853": { "compartment": "compartment_70101", "id": "reaction_10450853", "reactome": "R-DME-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450846" ], "products": [ "species_10450851" ], "modifiers": [], "additional_components": [ "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765" ] }, "reaction_10450849": { "compartment": "compartment_7660", "id": "reaction_10450849", "reactome": "R-DME-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10450840" ], "products": [ "species_113582", "species_10450846" ], "modifiers": [ [ "species_10450840", "catalyst" ] ], "additional_components": [ "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987" ] }, "reaction_10450876": { "compartment": "compartment_7660", "id": "reaction_10450876", "reactome": "R-DME-450292", "name": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450872", "species_10437390" ], "products": [ "species_10450874" ], "modifiers": [], "additional_components": [ "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550", "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550" ] }, "reaction_10437382": { "compartment": "compartment_7660", "id": "reaction_10437382", "reactome": "R-DME-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437328", "species_29358" ], "products": [ "species_113582", "species_10437332" ], "modifiers": [ [ "species_10437379", "catalyst" ] ], "additional_components": [ "FBgn0265193", "FBgn0265193", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P92208", "bsk" ] }, "reaction_10450901": { "compartment": "compartment_7660", "id": "reaction_10450901", "reactome": "R-DME-450325", "name": "c-FOS activation by phospho ERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10450899" ], "products": [ "species_113582", "species_10450872" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550", "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550", "P40417", "FBgn0003256" ] }, "reaction_10437461": { "compartment": "compartment_7660", "id": "reaction_10437461", "reactome": "R-DME-168440", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437332", "species_10437390" ], "products": [ "species_10437459" ], "modifiers": [], "additional_components": [ "FBgn0265193", "P18289", "phospho-Jra", "Q2PE13", "FBgn0265193" ] }, "reaction_10437393": { "compartment": "compartment_7660", "id": "reaction_10437393", "reactome": "R-DME-168136", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437386" ], "products": [ "species_113582", "species_10437390" ], "modifiers": [ [ "species_10437365", "catalyst" ] ], "additional_components": [] }, "reaction_10463567": { "compartment": "compartment_20699", "id": "reaction_10463567", "reactome": "R-DME-2022851", "name": "EXT1:EXT2 transfer GlcNAc to the heparan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10463526" ], "products": [ "species_10463552", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10463662": { "compartment": "compartment_20699", "id": "reaction_10463662", "reactome": "R-DME-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10463622" ], "products": [ "species_10463648", "species_742343" ], "modifiers": [ [ "species_10463653", "catalyst" ] ], "additional_components": [ "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "FBgn0020251" ] }, "reaction_10464814": { "compartment": "compartment_20699", "id": "reaction_10464814", "reactome": "R-DME-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463809", "species_741440" ], "products": [ "species_742343", "species_10463831" ], "modifiers": [ [ "species_10464807", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "FBgn0038755" ] }, "reaction_10463596": { "compartment": "compartment_20699", "id": "reaction_10463596", "reactome": "R-DME-2022856", "name": "EXT1:EXT2 transfers GlcNAc to heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10463593" ], "products": [ "species_10463526", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10463691": { "compartment": "compartment_20699", "id": "reaction_10463691", "reactome": "R-DME-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_10463688" ], "products": [ "species_10463622", "species_2022890" ], "modifiers": [ [ "species_10463653", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "FBgn0020251" ] }, "reaction_10463947": { "compartment": "compartment_17963", "id": "reaction_10463947", "reactome": "R-DME-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463833" ], "products": [ "species_10463945" ], "modifiers": [], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally" ] }, "reaction_10464822": { "compartment": "compartment_20699", "id": "reaction_10464822", "reactome": "R-DME-2076508", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463731", "species_741440" ], "products": [ "species_742343", "species_10463757" ], "modifiers": [ [ "species_10464819", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "FBgn0024230" ] }, "reaction_10464836": { "compartment": "compartment_20699", "id": "reaction_10464836", "reactome": "R-DME-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10463757" ], "products": [ "species_742343", "species_10463783" ], "modifiers": [ [ "species_10464833", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "Q8MRE7", "FBgn0053147", "Q9VWJ7", "FBgn0031005" ] }, "reaction_10463699": { "compartment": "compartment_20699", "id": "reaction_10463699", "reactome": "R-DME-2022919", "name": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463697", "species_914003" ], "products": [ "species_10463593", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10464802": { "compartment": "compartment_20699", "id": "reaction_10464802", "reactome": "R-DME-2076392", "name": "EXT1:EXT2 transfers GlcA to heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463552", "species_1889970" ], "products": [ "species_10463688", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10464800": { "compartment": "compartment_17963", "id": "reaction_10464800", "reactome": "R-DME-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10463757" ], "products": [ "species_742343", "species_10463783" ], "modifiers": [ [ "species_10464795", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "FBgn0053147" ] }, "reaction_10497796": { "compartment": "compartment_70101", "id": "reaction_10497796", "reactome": "R-DME-9630923", "name": "NFkB inhibitor binds NFkB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411", "species_10437415" ], "products": [ "species_10437417" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl" ] }, "reaction_10437457": { "compartment": "compartment_70101", "id": "reaction_10437457", "reactome": "R-DME-168166", "name": "NFkB complex is transported from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10468309": { "compartment": "compartment_7660", "id": "reaction_10468309", "reactome": "R-DME-3322427", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468258", "species_10447242" ], "products": [ "species_10468307" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0261617", "M9MS40", "FBgn0261617", "P18824", "arm", "Q8IMA8", "FBgn0085432" ] }, "reaction_10468260": { "compartment": "compartment_7660", "id": "reaction_10468260", "reactome": "R-DME-3299569", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468256", "species_10441673" ], "products": [ "species_10468258", "species_10457450", "species_10468252" ], "modifiers": [], "additional_components": [ "P16371", "GRO", "Q94517", "HDAC1", "Q8IMA8", "FBgn0085432", "P18824", "arm", "Q8IMA8", "FBgn0085432", "P16371", "GRO" ] }, "reaction_10468305": { "compartment": "compartment_7660", "id": "reaction_10468305", "reactome": "R-DME-3322424", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434736", "species_10468258", "species_10434726" ], "products": [ "species_10468303" ], "modifiers": [], "additional_components": [ "FBgn0019637", "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0037657", "Q9VHI1", "FBgn0037657", "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q94546", "FBgn0019637" ] }, "reaction_10468464": { "compartment": "compartment_7660", "id": "reaction_10468464", "reactome": "R-DME-3364014", "name": "Recruitment of SET1 methyltransferase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468432", "species_10468437", "species_10465286", "species_10468442", "species_10468460" ], "products": [ "species_10468462" ], "modifiers": [], "additional_components": [ "FBgn0023518", "FBgn0000139", "FBgn0031885", "FBgn0036973", "Q9V9W8", "PYGO", "Q961D9", "LGS", "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q9VPH8", "FBgn0036973", "Q9V9W8", "PYGO", "Q961D9", "LGS", "P18824", "arm", "Q9VM47", "FBgn0031885", "Q94545", "FBgn0000139", "Q8IMA8", "FBgn0085432", "Q8IRW8", "FBgn0023518" ] }, "reaction_10441675": { "compartment": "compartment_70101", "id": "reaction_10441675", "reactome": "R-DME-201669", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440609" ], "products": [ "species_10441673" ], "modifiers": [], "additional_components": [] }, "reaction_10468687": { "compartment": "compartment_70101", "id": "reaction_10468687", "reactome": "R-DME-3640844", "name": "RNF146 binds RibC-AXIN:TNKS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468683", "species_10468669" ], "products": [ "species_10468685" ], "modifiers": [], "additional_components": [ "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "FBgn0036897", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn" ] }, "reaction_10468716": { "compartment": "compartment_70101", "id": "reaction_10468716", "reactome": "R-DME-3640874", "name": "Ub-RibC-AXIN is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468701" ], "products": [ "species_10468679", "species_10426987", "species_10468669" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "B7Z078", "FBgn0036897", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "FBgn0027508", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0036897", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10468694": { "compartment": "compartment_70101", "id": "reaction_10468694", "reactome": "R-DME-3640858", "name": "Tankyrase ADP-ribosylates AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468691", "species_29360" ], "products": [ "species_197277", "species_10468683" ], "modifiers": [ [ "species_10468691", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508" ] }, "reaction_10470006": { "compartment": "compartment_70101", "id": "reaction_10470006", "reactome": "R-DME-4641134", "name": "SMURF2 binds AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437960", "species_10440493" ], "products": [ "species_10469994" ], "modifiers": [], "additional_components": [ "FBgn0029006", "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006" ] }, "reaction_10470021": { "compartment": "compartment_70101", "id": "reaction_10470021", "reactome": "R-DME-4641256", "name": "Ubiquitinated AXIN is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470001" ], "products": [ "species_10437960", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006", "FBgn0029006", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10470004": { "compartment": "compartment_70101", "id": "reaction_10470004", "reactome": "R-DME-4641129", "name": "AXIN is ubiquitinated by SMURF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469994", "species_10426987" ], "products": [ "species_10470001" ], "modifiers": [ [ "species_10469994", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006", "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006" ] }, "reaction_10468706": { "compartment": "compartment_70101", "id": "reaction_10468706", "reactome": "R-DME-3640862", "name": "Tankyrase binds AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468679", "species_10440493" ], "products": [ "species_10468691" ], "modifiers": [], "additional_components": [ "FBgn0027508", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508" ] }, "reaction_10468704": { "compartment": "compartment_70101", "id": "reaction_10468704", "reactome": "R-DME-3640861", "name": "RNF146 ubiquitinates ADP-ribosylated AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10468685" ], "products": [ "species_10468701" ], "modifiers": [ [ "species_10468685", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "B7Z078", "FBgn0036897", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn" ] }, "reaction_10468714": { "compartment": "compartment_70101", "id": "reaction_10468714", "reactome": "R-DME-3640872", "name": "USP34 deubiquitinates AXIN1,AXIN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10468701" ], "products": [ "species_10426987", "species_10468685" ], "modifiers": [ [ "species_10468711", "catalyst" ] ], "additional_components": [ "B7Z078", "FBgn0036897", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "FBgn0039214" ] }, "reaction_10472015": { "compartment": "compartment_7660", "id": "reaction_10472015", "reactome": "R-DME-5368580", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441673", "species_10472011" ], "products": [ "species_10472013" ], "modifiers": [], "additional_components": [ "FBgn0266557", "B7Z002", "FBgn0266557", "P18824", "arm" ] }, "reaction_10475439": { "compartment": "compartment_7660", "id": "reaction_10475439", "reactome": "R-DME-5665608", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468258", "species_10475435" ], "products": [ "species_10475437" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "P18824", "arm", "Q8IMA8", "FBgn0085432" ] }, "reaction_10468798": { "compartment": "compartment_7660", "id": "reaction_10468798", "reactome": "R-DME-3769391", "name": "XPO1 binds the beta-catenin:CBY complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468794", "species_10437629" ], "products": [ "species_10468796" ], "modifiers": [], "additional_components": [ "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta", "FBgn0020497", "Q9TVM2", "FBgn0020497", "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta" ] }, "reaction_10468427": { "compartment": "compartment_7660", "id": "reaction_10468427", "reactome": "R-DME-3361751", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468421", "species_10468423" ], "products": [ "species_10468256", "species_10468425" ], "modifiers": [], "additional_components": [ "O46036", "FBgn0020496", "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P16371", "GRO", "Q94517", "HDAC1", "P16371", "GRO", "Q94517", "HDAC1", "Q8IMA8", "FBgn0085432", "O46036", "FBgn0020496", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589" ] }, "reaction_10468810": { "compartment": "compartment_7660", "id": "reaction_10468810", "reactome": "R-DME-3769394", "name": "AKT phosphorylates CBY1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10468785" ], "products": [ "species_113582", "species_10468792" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "B9A0M5", "FBgn0067317", "P18824", "arm", "P18824", "arm", "B9A0M5", "FBgn0067317" ] }, "reaction_10468345": { "compartment": "compartment_7660", "id": "reaction_10468345", "reactome": "R-DME-3322434", "name": "XIAP dissociates from ub-TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468338" ], "products": [ "species_10468336", "species_10468315" ], "modifiers": [], "additional_components": [ "Q24307", "Diap2", "Q24306", "Diap1", "P16371", "GRO", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10468808": { "compartment": "compartment_7660", "id": "reaction_10468808", "reactome": "R-DME-3769393", "name": "YWHAZ binds p-CBY:CTNNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451202", "species_10468792" ], "products": [ "species_10468794" ], "modifiers": [], "additional_components": [ "P18824", "arm", "B9A0M5", "FBgn0067317", "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta" ] }, "reaction_10468343": { "compartment": "compartment_7660", "id": "reaction_10468343", "reactome": "R-DME-3322431", "name": "XIAP binds TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468315", "species_10468252" ], "products": [ "species_10468317" ], "modifiers": [], "additional_components": [ "Q24307", "Diap2", "Q24306", "Diap1", "P16371", "GRO", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10468806": { "compartment": "compartment_70101", "id": "reaction_10468806", "reactome": "R-DME-3769392", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468796" ], "products": [ "species_10468804" ], "modifiers": [], "additional_components": [ "Q9TVM2", "FBgn0020497", "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "B9A0M5", "FBgn0067317", "P18824", "arm", "Q9TVM2", "FBgn0020497" ] }, "reaction_10468341": { "compartment": "compartment_7660", "id": "reaction_10468341", "reactome": "R-DME-3322429", "name": "XIAP monoubiquinates TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10468317" ], "products": [ "species_10468338" ], "modifiers": [ [ "species_10468317", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "P16371", "GRO", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10474292": { "compartment": "compartment_7660", "id": "reaction_10474292", "reactome": "R-DME-5626938", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474288", "species_10441673" ], "products": [ "species_10474290" ], "modifiers": [], "additional_components": [ "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "Q9VA17", "FBgn0024288", "P18824", "arm", "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "Q9VA17", "FBgn0024288" ] }, "reaction_10468787": { "compartment": "compartment_7660", "id": "reaction_10468787", "reactome": "R-DME-3769383", "name": "CBY1 binds beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441673", "species_10468783" ], "products": [ "species_10468785" ], "modifiers": [], "additional_components": [ "FBgn0067317", "B9A0M5", "FBgn0067317", "P18824", "arm" ] }, "reaction_10441753": { "compartment": "compartment_876", "id": "reaction_10441753", "reactome": "R-DME-201677", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441725" ], "products": [ "species_29370", "species_10441750" ], "modifiers": [ [ "species_10441725", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880", "P09615", "WG", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P18537", "FZ", "P51140", "phospho-dsh", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880", "Q9VLZ6", "FBgn0031926", "A1Z9D7", "FBgn0000119", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880" ] }, "reaction_10459892": { "compartment": "compartment_70101", "id": "reaction_10459892", "reactome": "R-DME-1504186", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441723", "species_10441677" ], "products": [ "species_10441725" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880" ] }, "reaction_10468814": { "compartment": "compartment_70101", "id": "reaction_10468814", "reactome": "R-DME-3772434", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460946", "species_10441717" ], "products": [ "species_10468812" ], "modifiers": [], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984", "P51140", "phospho-dsh", "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10468824": { "compartment": "compartment_70101", "id": "reaction_10468824", "reactome": "R-DME-3772436", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10468812", "catalyst" ] ], "additional_components": [ "P51140", "phospho-dsh", "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10468821": { "compartment": "compartment_70101", "id": "reaction_10468821", "reactome": "R-DME-3772435", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441766" ], "products": [ "species_29370", "species_10441717" ], "modifiers": [ [ "species_10468818", "catalyst" ] ], "additional_components": [] }, "reaction_10441793": { "compartment": "compartment_70101", "id": "reaction_10441793", "reactome": "R-DME-201717", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441759" ], "products": [ "species_29370", "species_10441766" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10471507": { "compartment": "compartment_984", "id": "reaction_10471507", "reactome": "R-DME-5323545", "name": "Canonical WNT signaling through the atypical receptor RYK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471501", "species_10471503" ], "products": [ "species_10471505" ], "modifiers": [], "additional_components": [ "FBgn0024245", "P09615", "WG", "P28466", "FBgn0010194", "P09615", "WG", "P28466", "FBgn0010194", "Q9V422", "FBgn0024245" ] }, "reaction_10470012": { "compartment": "compartment_70101", "id": "reaction_10470012", "reactome": "R-DME-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470008", "species_10441759" ], "products": [ "species_10470010" ], "modifiers": [], "additional_components": [ "FBgn0261931", "P51140", "phospho-dsh", "Q9W326", "FBgn0261931" ] }, "reaction_10470023": { "compartment": "compartment_70101", "id": "reaction_10470023", "reactome": "R-DME-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470014" ], "products": [ "species_10470008", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9W326", "FBgn0261931", "P51140", "phospho-dsh", "FBgn0261931", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10459910": { "compartment": "compartment_70101", "id": "reaction_10459910", "reactome": "R-DME-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459898", "species_10426987" ], "products": [ "species_10459907" ], "modifiers": [ [ "species_10459898", "catalyst" ] ], "additional_components": [ "Q8IP45", "FBgn0261268", "Q9W5E1", "Roc1a", "P51140", "phospho-dsh", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P51140", "phospho-dsh", "Q8IP45", "FBgn0261268", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9W5E1", "Roc1a", "P51140", "phospho-dsh" ] }, "reaction_10470017": { "compartment": "compartment_70101", "id": "reaction_10470017", "reactome": "R-DME-4641159", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470010", "species_10426987" ], "products": [ "species_10470014" ], "modifiers": [ [ "species_10470010", "catalyst" ] ], "additional_components": [ "P51140", "phospho-dsh", "Q9W326", "FBgn0261931", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W326", "FBgn0261931", "P51140", "phospho-dsh", "P51140", "phospho-dsh", "Q9W326", "FBgn0261931" ] }, "reaction_10496688": { "compartment": "compartment_876", "id": "reaction_10496688", "reactome": "R-DME-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496685" ], "products": [ "species_29420", "species_10496660" ], "modifiers": [ [ "species_10496685", "catalyst" ] ], "additional_components": [ "Q0KHU4", "FBgn0083940", "species_29420", "Q0KHU4", "FBgn0083940", "species_29438", "Q0KHU4", "FBgn0083940", "species_29420" ] }, "reaction_10496683": { "compartment": "compartment_876", "id": "reaction_10496683", "reactome": "R-DME-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496679", "species_10496660" ], "products": [ "species_10496681" ], "modifiers": [], "additional_components": [ "Q9VXE5", "FBgn0025743", "Q9VIS1", "FBgn0032821", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "Q0KHU4", "FBgn0083940", "species_29438", "Q0KHU4", "FBgn0083940", "species_29438", "Q9VXE5", "FBgn0025743", "Q9VIS1", "FBgn0032821", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698" ] }, "reaction_10496403": { "compartment": "compartment_876", "id": "reaction_10496403", "reactome": "R-DME-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464321", "species_10440312" ], "products": [ "species_10496401" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29420", "Q9VW59", "RhoGDI" ] }, "reaction_10496358": { "compartment": "compartment_876", "id": "reaction_10496358", "reactome": "R-DME-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067", "species_29356" ], "products": [ "species_10464321", "species_29372" ], "modifiers": [ [ "species_10496355", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29420", "Q9VWL7", "FBgn0261461", "X2JEI9", "FBgn0031118", "Q9VDS5", "FBgn0038747", "Q9VDG2", "FBgn0026056", "Q0E938", "FBgn0028494", "Q9VIS1", "FBgn0032821", "Q9W4A9", "FBgn0029778", "Q9V9S7", "FBgn0039883", "Q9VDE9", "RhoGAP93B", "B7Z058", "FBgn0036518" ] }, "reaction_10496311": { "compartment": "compartment_876", "id": "reaction_10496311", "reactome": "R-DME-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10464321" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10496308", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "P25157", "FBgn0000384", "Q9VAS8", "FBgn0264324", "Q9NHV9", "FBgn0040068", "P91621", "FBgn0085447" ] }, "reaction_10498558": { "compartment": "compartment_876", "id": "reaction_10498558", "reactome": "R-DME-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067" ], "products": [ "species_10498556" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10496399": { "compartment": "compartment_876", "id": "reaction_10496399", "reactome": "R-DME-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067", "species_10496395" ], "products": [ "species_10496397" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "O97111", "FBgn0026192", "B7YZT5", "FBgn0286511", "B7Z0W0", "FBgn0267698", "A1Z7T0", "FBgn0020621", "Q9W1B0", "FBgn0023081", "Q8IQE6", "FBgn0052082", "Q7K490", "FBgn0033996", "Q9VXE5", "FBgn0025743", "M9PE53", "FBgn0264272", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "Q9VF87", "FBgn0038320", "O97111", "FBgn0026192", "B7YZT5", "FBgn0286511", "B7Z0W0", "FBgn0267698", "A1Z7T0", "FBgn0020621", "Q9W1B0", "FBgn0023081", "Q8IQE6", "FBgn0052082", "Q7K490", "FBgn0033996", "Q9VXE5", "FBgn0025743", "M9PE53", "FBgn0264272", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10498562": { "compartment": "compartment_876", "id": "reaction_10498562", "reactome": "R-DME-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439139" ], "products": [ "species_10498560" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "P40793", "FBgn0010341", "species_29438" ] }, "reaction_10496452": { "compartment": "compartment_876", "id": "reaction_10496452", "reactome": "R-DME-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10439139" ], "products": [ "species_29372", "species_10496432" ], "modifiers": [ [ "species_10496449", "catalyst" ] ], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "species_29420", "P40793", "FBgn0010341", "Q9VX92", "FBgn0030808", "Q9VDE9", "RhoGAP93B", "Q8T0G4", "FBgn0039994", "Q9VTU3", "FBgn0036257", "B7Z058", "FBgn0036518", "Q0E938", "FBgn0028494" ] }, "reaction_10496438": { "compartment": "compartment_876", "id": "reaction_10496438", "reactome": "R-DME-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440312", "species_10496432" ], "products": [ "species_10496436" ], "modifiers": [], "additional_components": [ "species_29420", "P40793", "FBgn0010341", "P40793", "FBgn0010341", "species_29420", "Q9VW59", "RhoGDI" ] }, "reaction_10496445": { "compartment": "compartment_876", "id": "reaction_10496445", "reactome": "R-DME-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496432" ], "products": [ "species_29420", "species_10439139" ], "modifiers": [ [ "species_10496442", "catalyst" ] ], "additional_components": [ "species_29420", "P40793", "FBgn0010341", "species_29438", "P40793", "FBgn0010341", "P25157", "FBgn0000384", "A1ZBA1", "FBgn0050115", "Q9W0S2", "FBgn0264707", "Q9VVC6", "FBgn0261547", "Q7KU89", "FBgn0035802", "Q7K4E0", "FBgn0050440" ] }, "reaction_10498596": { "compartment": "compartment_876", "id": "reaction_10498596", "reactome": "R-DME-9693125", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498572", "species_10498592" ], "products": [ "species_10498594" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "A8JQT5", "FBgn0265082", "P48608", "FBgn0011202", "Q8IQE6", "FBgn0052082", "A8JQT5", "FBgn0265082", "P48608", "FBgn0011202", "Q8IQE6", "FBgn0052082", "P48148", "Rho1", "species_29438" ] }, "reaction_10498649": { "compartment": "compartment_876", "id": "reaction_10498649", "reactome": "R-DME-9693282", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10498572" ], "products": [ "species_29372", "species_10498570" ], "modifiers": [ [ "species_10498646", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29438", "species_29420", "P48148", "Rho1", "Q9VTU3", "FBgn0036257" ] }, "reaction_10498575": { "compartment": "compartment_876", "id": "reaction_10498575", "reactome": "R-DME-9693111", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10498570" ], "products": [ "species_29420", "species_10498572" ], "modifiers": [ [ "species_10498570", "catalyst" ] ], "additional_components": [ "species_29420", "P48148", "Rho1", "P48148", "Rho1", "species_29438", "species_29420", "P48148", "Rho1" ] }, "reaction_10496723": { "compartment": "compartment_876", "id": "reaction_10496723", "reactome": "R-DME-9018778", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496719", "species_10496695" ], "products": [ "species_10496721" ], "modifiers": [], "additional_components": [ "Q9VJ79", "FBgn0085370", "Q9VFI9", "FBgn0038237", "Q9VXE3", "FBgn0026181", "Q8IP45", "FBgn0261268", "M9PG08", "FBgn0036980", "species_29438", "M9PG08", "FBgn0036980", "species_29438", "Q9VJ79", "FBgn0085370", "Q9VFI9", "FBgn0038237", "Q9VXE3", "FBgn0026181", "Q8IP45", "FBgn0261268" ] }, "reaction_10496697": { "compartment": "compartment_74700", "id": "reaction_10496697", "reactome": "R-DME-9018774", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496693" ], "products": [ "species_10496695" ], "modifiers": [], "additional_components": [ "FBgn0036980", "M9PG08", "FBgn0036980", "species_29438" ] }, "reaction_10496752": { "compartment": "compartment_74700", "id": "reaction_10496752", "reactome": "R-DME-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496748", "species_10496727" ], "products": [ "species_10496750" ], "modifiers": [], "additional_components": [ "Q9VVE5", "FBgn0260943", "Q8IP45", "FBgn0261268", "M9PG08", "FBgn0036980", "species_29438", "M9PG08", "FBgn0036980", "species_29438", "Q9VVE5", "FBgn0260943", "Q8IP45", "FBgn0261268" ] }, "reaction_10496732": { "compartment": "compartment_70101", "id": "reaction_10496732", "reactome": "R-DME-9018785", "name": "RHOBTB2 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496725" ], "products": [ "species_10496727" ], "modifiers": [ [ "species_10496729", "catalyst" ] ], "additional_components": [ "FBgn0036980", "M9PG08", "FBgn0036980", "species_29438", "P02828", "FBgn0001233", "Q24276", "FBgn0011573" ] }, "reaction_10496496": { "compartment": "compartment_876", "id": "reaction_10496496", "reactome": "R-DME-9013452", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460" ], "products": [ "species_10475550" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438" ] }, "reaction_10498627": { "compartment": "compartment_876", "id": "reaction_10498627", "reactome": "R-DME-9693243", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460" ], "products": [ "species_10498625" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "species_29438", "P48148", "Rho1" ] }, "reaction_10496468": { "compartment": "compartment_876", "id": "reaction_10496468", "reactome": "R-DME-9013437", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496460" ], "products": [ "species_29372", "species_10496456" ], "modifiers": [ [ "species_10496465", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420", "Q9VIS1", "FBgn0032821", "Q9VX32", "RhoGAPp190", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685" ] }, "reaction_10498644": { "compartment": "compartment_20699", "id": "reaction_10498644", "reactome": "R-DME-9693250", "name": "RHOD binds effectors at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498625", "species_10498640" ], "products": [ "species_10498642" ], "modifiers": [], "additional_components": [ "species_29438", "P48148", "Rho1", "Q8SX68", "FBgn0034308", "Q8SX68", "FBgn0034308", "species_29438", "P48148", "Rho1" ] }, "reaction_10498613": { "compartment": "compartment_876", "id": "reaction_10498613", "reactome": "R-DME-9693207", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460" ], "products": [ "species_10498611" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438" ] }, "reaction_10498621": { "compartment": "compartment_17906", "id": "reaction_10498621", "reactome": "R-DME-9693214", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498617", "species_10498611" ], "products": [ "species_10498619" ], "modifiers": [], "additional_components": [ "Q9VXE5", "FBgn0025743", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE5", "FBgn0025743" ] }, "reaction_10496494": { "compartment": "compartment_876", "id": "reaction_10496494", "reactome": "R-DME-9013438", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496490", "species_10475550" ], "products": [ "species_10496492" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "Q9VPY3", "FBgn0031317", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "Q9VPY3", "FBgn0031317" ] }, "reaction_10496463": { "compartment": "compartment_876", "id": "reaction_10496463", "reactome": "R-DME-9013435", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496456" ], "products": [ "species_29420", "species_10496460" ], "modifiers": [ [ "species_10496456", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420" ] }, "reaction_10498607": { "compartment": "compartment_70101", "id": "reaction_10498607", "reactome": "R-DME-9693198", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460", "species_10498603" ], "products": [ "species_10498605" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "P48603", "FBgn0011570", "Q9VDE9", "RhoGAP93B", "Q9VJ26", "FBgn0032731", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P18091", "FBgn0000667", "Q02645", "FBgn0263391", "O76742", "FBgn0015795", "Q9VU84", "FBgn0036372", "P08928", "FBgn0002525", "Q8IPI3", "FBgn0259111", "Q9VTU3", "FBgn0036257", "Q9VW40", "FBgn0036908", "P48608", "FBgn0011202", "P48603", "FBgn0011570", "Q9VDE9", "RhoGAP93B", "Q9VJ26", "FBgn0032731", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P18091", "FBgn0000667", "Q02645", "FBgn0263391", "O76742", "FBgn0015795", "Q9VU84", "FBgn0036372", "P08928", "FBgn0002525", "Q8IPI3", "FBgn0259111", "Q9VTU3", "FBgn0036257", "Q9VW40", "FBgn0036908", "P48148", "Rho1", "species_29438" ] }, "reaction_10496514": { "compartment": "compartment_70101", "id": "reaction_10496514", "reactome": "R-DME-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496508", "species_10440312" ], "products": [ "species_10496512" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29420", "Q9VW59", "RhoGDI", "species_29420", "P48554", "FBgn0014011", "P40792", "RAC1_DROME" ] }, "reaction_10496532": { "compartment": "compartment_70101", "id": "reaction_10496532", "reactome": "R-DME-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496508" ], "products": [ "species_10434896", "species_29420" ], "modifiers": [ [ "species_10496529", "catalyst" ] ], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29420", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "X2JC00", "FBgn0025836", "Q9NHV9", "FBgn0040068", "Q7K4E0", "FBgn0050440", "P91621", "FBgn0085447" ] }, "reaction_10496534": { "compartment": "compartment_876", "id": "reaction_10496534", "reactome": "R-DME-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896" ], "products": [ "species_10475589" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10498823": { "compartment": "compartment_876", "id": "reaction_10498823", "reactome": "R-DME-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896" ], "products": [ "species_10498821" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10496522": { "compartment": "compartment_70101", "id": "reaction_10496522", "reactome": "R-DME-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896", "species_10496518" ], "products": [ "species_10496520" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "B7YZT5", "FBgn0286511", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "B7YZT5", "FBgn0286511", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10498813": { "compartment": "compartment_17906", "id": "reaction_10498813", "reactome": "R-DME-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498797", "species_10498809" ], "products": [ "species_10498811" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496527": { "compartment": "compartment_70101", "id": "reaction_10496527", "reactome": "R-DME-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896", "species_29356" ], "products": [ "species_29372", "species_10496508" ], "modifiers": [ [ "species_10496524", "catalyst" ] ], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29420", "Q9VX32", "RhoGAPp190", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685" ] }, "reaction_10498815": { "compartment": "compartment_876", "id": "reaction_10498815", "reactome": "R-DME-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896" ], "products": [ "species_10498797" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496786": { "compartment": "compartment_876", "id": "reaction_10496786", "reactome": "R-DME-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496782", "species_10496756" ], "products": [ "species_10496784" ], "modifiers": [], "additional_components": [ "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "Q0KHU4", "FBgn0083940", "species_29438", "Q0KHU4", "FBgn0083940", "species_29438", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698" ] }, "reaction_10496790": { "compartment": "compartment_876", "id": "reaction_10496790", "reactome": "R-DME-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496788" ], "products": [ "species_29420", "species_10496756" ], "modifiers": [], "additional_components": [ "Q0KHU4", "FBgn0083940", "species_29420", "Q0KHU4", "FBgn0083940", "species_29438" ] }, "reaction_10495680": { "compartment": "compartment_70101", "id": "reaction_10495680", "reactome": "R-DME-8981637", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10434906" ], "products": [ "species_29372", "species_10434904" ], "modifiers": [ [ "species_10495677", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420", "X2JDY8", "FBgn0030685", "Q9VX32", "RhoGAPp190", "Q8T0G4", "FBgn0039994", "A1ZAW3", "FBgn0034249", "H9XVN1", "FBgn0259216", "Q9VIS1", "FBgn0032821", "B7Z058", "FBgn0036518", "Q9VTU3", "FBgn0036257", "A8JR05", "FBgn0285955" ] }, "reaction_10496244": { "compartment": "compartment_70101", "id": "reaction_10496244", "reactome": "R-DME-9012835", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440312", "species_10434904" ], "products": [ "species_10496242" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29420", "Q9VW59", "RhoGDI" ] }, "reaction_10496248": { "compartment": "compartment_876", "id": "reaction_10496248", "reactome": "R-DME-9013006", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434906" ], "products": [ "species_10496246" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438" ] }, "reaction_10495532": { "compartment": "compartment_70101", "id": "reaction_10495532", "reactome": "R-DME-8980691", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10495529", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "M9PBE1", "FBgn0032796", "Q9VVC6", "FBgn0261547", "Q8IQ97", "FBgn0003041", "Q9NHV9", "FBgn0040068", "A1ZAN6", "FBgn0023172", "M9PHU0", "FBgn0263706", "Q7K4E0", "FBgn0050440", "Q9VW85", "FBgn0261556", "Q7KVD1", "FBgn0024277" ] }, "reaction_10496302": { "compartment": "compartment_876", "id": "reaction_10496302", "reactome": "R-DME-9013009", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496298", "species_10434906" ], "products": [ "species_10496300" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "B7YZT5", "FBgn0286511", "Q9XYY9", "FBgn0026374", "Q9W179", "FBgn0035001", "A1Z7T0", "FBgn0020621", "Q9VXE3", "FBgn0026181", "Q9V4P1", "FBgn0261385", "M9MSM5", "FBgn0025641", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "B7YZT5", "FBgn0286511", "Q9XYY9", "FBgn0026374", "Q9W179", "FBgn0035001", "A1Z7T0", "FBgn0020621", "Q9VXE3", "FBgn0026181", "Q9V4P1", "FBgn0261385", "M9MSM5", "FBgn0025641" ] }, "reaction_10496569": { "compartment": "compartment_876", "id": "reaction_10496569", "reactome": "R-DME-9017488", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496562" ], "products": [ "species_29372", "species_10496564" ], "modifiers": [ [ "species_10496566", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "P40793", "FBgn0010341", "species_29420", "Q9VX32", "RhoGAPp190", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685" ] }, "reaction_10496572": { "compartment": "compartment_876", "id": "reaction_10496572", "reactome": "R-DME-9017491", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496564" ], "products": [ "species_29420", "species_10496562" ], "modifiers": [ [ "species_10457618", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "species_29420", "P40793", "FBgn0010341", "species_29438", "FBgn0031216" ] }, "reaction_10496609": { "compartment": "compartment_70101", "id": "reaction_10496609", "reactome": "R-DME-9018746", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496591", "species_10496605" ], "products": [ "species_10496607" ], "modifiers": [], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "Q9VIS1", "FBgn0032821", "A8JNK4", "FBgn0035533", "B7Z0W0", "FBgn0267698", "Q9VIS1", "FBgn0032821", "A8JNK4", "FBgn0035533", "B7Z0W0", "FBgn0267698", "P40793", "FBgn0010341", "species_29438" ] }, "reaction_10496614": { "compartment": "compartment_876", "id": "reaction_10496614", "reactome": "R-DME-9018747", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496593" ], "products": [ "species_10496591", "species_29420" ], "modifiers": [ [ "species_10496611", "catalyst" ] ], "additional_components": [ "species_29420", "P40793", "FBgn0010341", "P40793", "FBgn0010341", "species_29438", "M9ND00", "FBgn0023388" ] }, "reaction_10496598": { "compartment": "compartment_70101", "id": "reaction_10496598", "reactome": "R-DME-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496591", "species_29356" ], "products": [ "species_29372", "species_10496593" ], "modifiers": [ [ "species_10496595", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "species_29420", "P40793", "FBgn0010341", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685", "A8JR05", "FBgn0285955" ] }, "reaction_10496826": { "compartment": "compartment_876", "id": "reaction_10496826", "reactome": "R-DME-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496591" ], "products": [ "species_10496824" ], "modifiers": [], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "P40793", "FBgn0010341", "species_29438" ] }, "reaction_10496626": { "compartment": "compartment_876", "id": "reaction_10496626", "reactome": "R-DME-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496622", "species_10440312" ], "products": [ "species_10496624" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "Q9VW59", "RhoGDI", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496628": { "compartment": "compartment_876", "id": "reaction_10496628", "reactome": "R-DME-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496620" ], "products": [ "species_10496622" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496653": { "compartment": "compartment_876", "id": "reaction_10496653", "reactome": "R-DME-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496622", "species_10496649" ], "products": [ "species_10496651" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10455477": { "compartment": "compartment_20699", "id": "reaction_10455477", "reactome": "R-DME-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10455474", "catalyst" ] ], "additional_components": [ "P53624", "FBgn0259170", "Q8IMK0", "FBgn0051202" ] }, "reaction_10455523": { "compartment": "compartment_20699", "id": "reaction_10455523", "reactome": "R-DME-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10455474", "catalyst" ] ], "additional_components": [ "P53624", "FBgn0259170", "Q8IMK0", "FBgn0051202" ] }, "reaction_10455521": { "compartment": "compartment_20699", "id": "reaction_10455521", "reactome": "R-DME-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10455474", "catalyst" ] ], "additional_components": [ "CHEBI:60629", "CHEBI:60628", "CHEBI:60627", "P53624", "FBgn0259170", "Q8IMK0", "FBgn0051202" ] }, "reaction_10461309": { "compartment": "compartment_161320", "id": "reaction_10461309", "reactome": "R-DME-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10461306", "catalyst" ] ], "additional_components": [ "FBgn0014417" ] }, "reaction_10464861": { "compartment": "compartment_17938", "id": "reaction_10464861", "reactome": "R-DME-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_2090045" ], "products": [ "species_2090053", "species_76194" ], "modifiers": [ [ "species_10461235", "catalyst" ] ], "additional_components": [ "Q9W4F7", "FBgn0029737" ] }, "reaction_10464859": { "compartment": "compartment_161320", "id": "reaction_10464859", "reactome": "R-DME-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_1605637", "species_2090063" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_10463705": { "compartment": "compartment_876", "id": "reaction_10463705", "reactome": "R-DME-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461260" ], "products": [ "species_10460901" ], "modifiers": [], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "Q24114", "dally" ] }, "reaction_10464857": { "compartment": "compartment_161320", "id": "reaction_10464857", "reactome": "R-DME-2090043", "name": "SGSH hydrolyses Heparan sulfate chain(7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090070" ], "products": [ "species_1606845", "species_2090045" ], "modifiers": [ [ "species_10461290", "catalyst" ] ], "additional_components": [ "FBgn0038660" ] }, "reaction_10464855": { "compartment": "compartment_161320", "id": "reaction_10464855", "reactome": "R-DME-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_1678743", "species_2065212" ], "modifiers": [ [ "species_10461306", "catalyst" ] ], "additional_components": [ "FBgn0014417" ] }, "reaction_10461238": { "compartment": "compartment_17938", "id": "reaction_10461238", "reactome": "R-DME-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_2090069", "species_76194" ], "modifiers": [ [ "species_10461235", "catalyst" ] ], "additional_components": [ "Q9W4F7", "FBgn0029737" ] }, "reaction_10461301": { "compartment": "compartment_161320", "id": "reaction_10461301", "reactome": "R-DME-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090033", "species_1605715" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10461298", "catalyst" ] ], "additional_components": [ "FBgn0032343" ] }, "reaction_10464853": { "compartment": "compartment_161320", "id": "reaction_10464853", "reactome": "R-DME-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090055" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10461298", "catalyst" ] ], "additional_components": [ "FBgn0032343" ] }, "reaction_10461293": { "compartment": "compartment_161320", "id": "reaction_10461293", "reactome": "R-DME-1678708", "name": "SGSH hydrolyses Heparan sulfate chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090072" ], "products": [ "species_2090040", "species_1606845" ], "modifiers": [ [ "species_10461290", "catalyst" ] ], "additional_components": [ "FBgn0038660" ] }, "reaction_10461228": { "compartment": "compartment_161320", "id": "reaction_10461228", "reactome": "R-DME-1678650", "name": "IDS hydrolyses Heparan sulfate chain(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090080", "species_1605715" ], "products": [ "species_2090055", "species_1606845" ], "modifiers": [ [ "species_10461225", "catalyst" ] ], "additional_components": [ "Q9VZP8", "FBgn0035445", "species_74016" ] }, "reaction_10460935": { "compartment": "compartment_161320", "id": "reaction_10460935", "reactome": "R-DME-1667005", "name": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10460901" ], "products": [ "species_2090033", "species_10460923" ], "modifiers": [ [ "species_10460932", "catalyst" ] ], "additional_components": [ "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VE79", "FBgn0038611" ] }, "reaction_10461351": { "compartment": "compartment_161320", "id": "reaction_10461351", "reactome": "R-DME-1678854", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065212" ], "products": [ "species_1678868", "species_2090075" ], "modifiers": [ [ "species_10461348", "catalyst" ], [ "species_427963", "inhibitor" ] ], "additional_components": [ "A1ZBG9", "FBgn0034417" ] }, "reaction_10461285": { "compartment": "compartment_876", "id": "reaction_10461285", "reactome": "R-DME-1678694", "name": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10461260" ], "products": [ "species_10461280", "species_2090023" ], "modifiers": [ [ "species_10461282", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "FBgn0038611" ] }, "reaction_10496818": { "compartment": "compartment_70101", "id": "reaction_10496818", "reactome": "R-DME-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496814", "species_10496796" ], "products": [ "species_10496816" ], "modifiers": [], "additional_components": [ "Q960V3", "FBgn0262872", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "Q8IMX7", "Miro", "species_29438", "Q8IMX7", "Miro", "species_29438", "Q960V3", "FBgn0262872", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596" ] }, "reaction_10496820": { "compartment": "compartment_70101", "id": "reaction_10496820", "reactome": "R-DME-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496796" ], "products": [ "species_10496798", "species_29372" ], "modifiers": [ [ "species_10496796", "catalyst" ] ], "additional_components": [ "Q8IMX7", "Miro", "species_29438", "Q8IMX7", "Miro", "species_29420", "Q8IMX7", "Miro", "species_29438" ] }, "reaction_10448207": { "compartment": "compartment_20699", "id": "reaction_10448207", "reactome": "R-DME-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10448204", "catalyst" ] ], "additional_components": [ "Q9VPJ1", "FBgn0026787", "Q8IPJ4", "FBgn0028703" ] }, "reaction_10448172": { "compartment": "compartment_172574", "id": "reaction_10448172", "reactome": "R-DME-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10448169", "catalyst" ] ], "additional_components": [ "FBgn0028703" ] }, "reaction_10448195": { "compartment": "compartment_876", "id": "reaction_10448195", "reactome": "R-DME-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10448184", "catalyst" ] ], "additional_components": [ "FBgn0040297" ] }, "reaction_10448179": { "compartment": "compartment_171062", "id": "reaction_10448179", "reactome": "R-DME-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10448174", "catalyst" ] ], "additional_components": [ "FBgn0028703" ] }, "reaction_209074": { "compartment": "compartment_984", "id": "reaction_209074", "reactome": "R-DME-209074", "name": "WG, FZ and ARR bind to each other", "reversible": "false", "notes": "The extracellular ligand Wingless (WG) binds to the extracellular domains of the plasma membrane Frizzled (FZ/FZ2) and Arrow (ARR) receptors. Both of these transmembrane receptors additionally interact with each other.", "reactants": [ "species_206202", "species_205797", "species_206546" ], "products": [ "species_206872" ], "modifiers": [], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR" ] }, "reaction_209108": { "compartment": "compartment_876", "id": "reaction_209108", "reactome": "R-DME-209108", "name": "Membrane-bound GISH binds to ARR receptor complex", "reversible": "false", "notes": "The plasma membrane tethered CKIgamma orthologue, GISH, complexes with the cytoplasmic tail of Arrow (ARR).", "reactants": [ "species_205695", "species_206872" ], "products": [ "species_206907" ], "modifiers": [], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH" ] }, "reaction_209135": { "compartment": "compartment_70101", "id": "reaction_209135", "reactome": "R-DME-209135", "name": "GISH further phosphorylates ARR in the receptor complex", "reversible": "false", "notes": "The bound kinase GISH phosphorylates two further residues on Arrow's (ARR) tail. Thr1493 and Thr1479 in Human LRP6 are phosphorylated by CKIgamma.", "reactants": [ "species_113592", "species_206800" ], "products": [ "species_29370", "species_206613" ], "modifiers": [ [ "species_206800", "catalyst" ] ], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "Q95V09", "ARR", "P09615", "WG", "Q86BR9", "GISH", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P18537", "FZ", "Q9VVX3", "FZ2", "Q95V09", "ARR", "P09615", "WG", "Q86BR9", "GISH" ] }, "reaction_209118": { "compartment": "compartment_70101", "id": "reaction_209118", "reactome": "R-DME-209118", "name": "Membrane localised SGG phosphorylates ARR", "reversible": "false", "notes": "The resulting transmembrane co-receptor complex is now primed for phosphorylation on the C-terminal tail of Arrow (ARR) by a membrane localised Shaggy (SGG). Ser1490 in Human LRP6 is phosphorylated by GSK3beta.", "reactants": [ "species_113592", "species_206907" ], "products": [ "species_29370", "species_206800" ], "modifiers": [ [ "species_5263693", "catalyst" ] ], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P18537", "FZ", "Q9VVX3", "FZ2", "Q95V09", "ARR", "P09615", "WG", "Q86BR9", "GISH" ] }, "reaction_10481336": { "compartment": "compartment_876", "id": "reaction_10481336", "reactome": "R-DME-6798258", "name": "PRTPRF, PTPRS, PTPRD bind LRRC4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481332", "species_10446397" ], "products": [ "species_10481334" ], "modifiers": [], "additional_components": [ "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "FBgn0000464", "P16621", "FBgn0000464", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435" ] }, "reaction_10446403": { "compartment": "compartment_70101", "id": "reaction_10446403", "reactome": "R-DME-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446392", "species_10446397" ], "products": [ "species_10446401" ], "modifiers": [], "additional_components": [ "Q9VU88", "FBgn0036376", "M9PCD4", "FBgn0046704", "FBgn0000464", "P16621", "FBgn0000464", "Q9VU88", "FBgn0036376", "M9PCD4", "FBgn0046704" ] }, "reaction_10481248": { "compartment": "compartment_876", "id": "reaction_10481248", "reactome": "R-DME-6797554", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442084", "species_10481244" ], "products": [ "species_10481246" ], "modifiers": [], "additional_components": [ "FBgn0036372", "A1Z9K8", "FBgn0040752", "Q7KT70", "FBgn0001987", "Q9W1B3", "FBgn0034972", "Q9VIC7", "FBgn0051146", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "Q7K1T1", "FBgn0259978", "A1Z9K8", "FBgn0040752", "Q7KT70", "FBgn0001987", "Q9W1B3", "FBgn0034972", "Q9VIC7", "FBgn0051146", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "Q7K1T1", "FBgn0259978", "Q9VU84", "FBgn0036372" ] }, "reaction_10481136": { "compartment": "compartment_70101", "id": "reaction_10481136", "reactome": "R-DME-6797553", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445828", "species_10481132" ], "products": [ "species_10481134" ], "modifiers": [], "additional_components": [ "FBgn0013759", "Q9VFU8", "FBgn0004049", "Q9V8R9", "FBgn0010434", "Q9VFU8", "FBgn0004049", "Q9V8R9", "FBgn0010434", "Q24210", "FBgn0013759" ] }, "reaction_10488289": { "compartment": "compartment_876", "id": "reaction_10488289", "reactome": "R-DME-8849906", "name": "SALM1 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488267", "species_10488250" ], "products": [ "species_10488287" ], "modifiers": [], "additional_components": [ "FBgn0031016", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "Q9VWI6", "FBgn0031016" ] }, "reaction_10488305": { "compartment": "compartment_876", "id": "reaction_10488305", "reactome": "R-DME-8849908", "name": "SALM4 binds flotillin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488301", "species_10488265" ], "products": [ "species_10488303" ], "modifiers": [], "additional_components": [ "O61492", "FBgn0264078", "FBgn0031016", "Q9VWI6", "FBgn0031016", "O61492", "FBgn0264078" ] }, "reaction_10488275": { "compartment": "compartment_876", "id": "reaction_10488275", "reactome": "R-DME-8849882", "name": "SALMs 1-4 bind reticulon 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488271", "species_10488265" ], "products": [ "species_10488273" ], "modifiers": [], "additional_components": [ "FBgn0053113", "FBgn0031016", "Q9VWI6", "FBgn0031016", "E1JHT6", "FBgn0053113" ] }, "reaction_10488263": { "compartment": "compartment_876", "id": "reaction_10488263", "reactome": "R-DME-8849881", "name": "SALM2 associate with AMPA and NMDA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488259", "species_10488257" ], "products": [ "species_10488261" ], "modifiers": [], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "FBgn0031016", "Q9VWI6", "FBgn0031016", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382" ] }, "reaction_10488281": { "compartment": "compartment_876", "id": "reaction_10488281", "reactome": "R-DME-8849891", "name": "SALMs 1-3 bind to PSD-95 family members", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488277", "species_10488257" ], "products": [ "species_10488279" ], "modifiers": [], "additional_components": [ "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "FBgn0031016", "Q9VWI6", "FBgn0031016", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624" ] }, "reaction_10488252": { "compartment": "compartment_876", "id": "reaction_10488252", "reactome": "R-DME-8849878", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488248", "species_10449288" ], "products": [ "species_10488250" ], "modifiers": [], "additional_components": [ "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382" ] }, "reaction_10489100": { "compartment": "compartment_876", "id": "reaction_10489100", "reactome": "R-DME-8855648", "name": "SALM3 binds LAR-RPTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488269", "species_10446397" ], "products": [ "species_10489098" ], "modifiers": [], "additional_components": [ "FBgn0031016", "FBgn0000464", "P16621", "FBgn0000464", "Q9VWI6", "FBgn0031016" ] }, "reaction_10488285": { "compartment": "compartment_876", "id": "reaction_10488285", "reactome": "R-DME-8849900", "name": "SALMs1-3 bind each other in cis interactions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488257" ], "products": [ "species_10488283" ], "modifiers": [], "additional_components": [ "FBgn0031016", "Q9VWI6", "FBgn0031016" ] }, "reaction_10453051": { "compartment": "compartment_984", "id": "reaction_10453051", "reactome": "R-DME-500717", "name": "Activation of GRIK3 homomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446852", "species_10453044" ], "products": [ "species_10453048" ], "modifiers": [ [ "species_10453044", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382", "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382" ] }, "reaction_10453046": { "compartment": "compartment_984", "id": "reaction_10453046", "reactome": "R-DME-500708", "name": "GRIK3 homomer binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10451326" ], "products": [ "species_10453044" ], "modifiers": [], "additional_components": [ "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382" ] }, "reaction_10451534": { "compartment": "compartment_984", "id": "reaction_10451534", "reactome": "R-DME-451309", "name": "Edited Kainate Receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10451530" ], "products": [ "species_10451532" ], "modifiers": [], "additional_components": [ "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "species_352022", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "species_352022", "species_210382" ] }, "reaction_10451537": { "compartment": "compartment_984", "id": "reaction_10451537", "reactome": "R-DME-451310", "name": "Activation of Edited Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10451532", "catalyst" ] ], "additional_components": [ "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "species_352022", "species_210382" ] }, "reaction_10451406": { "compartment": "compartment_876", "id": "reaction_10451406", "reactome": "R-DME-451283", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10451402" ], "products": [ "species_10451404" ], "modifiers": [], "additional_components": [ "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "species_352022", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "species_352022", "species_210382" ] }, "reaction_10451540": { "compartment": "compartment_70101", "id": "reaction_10451540", "reactome": "R-DME-451311", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10451404", "catalyst" ] ], "additional_components": [ "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "species_352022", "species_210382" ] }, "reaction_10442563": { "compartment": "compartment_70101", "id": "reaction_10442563", "reactome": "R-DME-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442464", "species_29438" ], "products": [ "species_10442466", "species_29420" ], "modifiers": [ [ "species_10442560", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "A1ZAN6", "FBgn0023172", "A1ZBA1", "FBgn0050115", "Q9W0S2", "FBgn0264707", "Q8IQ97", "FBgn0003041", "A8DZ19", "FBgn0015803", "Q9VVC6", "FBgn0261547", "Q7K4E0", "FBgn0050440", "P26675", "Sos", "P91621", "FBgn0085447", "M9PBE1", "FBgn0032796", "M9ND00", "FBgn0023388", "X2JC00", "FBgn0025836", "P25157", "FBgn0000384", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VW85", "FBgn0261556" ] }, "reaction_10440306": { "compartment": "compartment_13231", "id": "reaction_10440306", "reactome": "R-DME-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437429" ], "products": [ "species_10437365" ], "modifiers": [], "additional_components": [] }, "reaction_10442593": { "compartment": "compartment_70101", "id": "reaction_10442593", "reactome": "R-DME-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_29370", "species_10437429" ], "modifiers": [ [ "species_10442466", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10432761": { "compartment": "compartment_7660", "id": "reaction_10432761", "reactome": "R-DME-76056", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432757", "species_10432697" ], "products": [ "species_10432759" ], "modifiers": [], "additional_components": [ "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463" ] }, "reaction_10457699": { "compartment": "compartment_70101", "id": "reaction_10457699", "reactome": "R-DME-1013020", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10457696", "catalyst" ] ], "additional_components": [ "B7YZX2", "FBgn0032706", "species_352011", "Q9V3Q9", "FBgn0260446", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_216283": { "compartment": "compartment_7660", "id": "reaction_216283", "reactome": "R-DME-216283", "name": "RDX binds to and ubiquitinates CI", "reversible": "false", "notes": "HIB or Roadkill (RDX) is transcriptionally induced by Hedgehog signalling and binds directly to Cubitus Interruptus (CI), likely in competition with Supressor of Fused (SU(FU)), to link CI with a Cul3 aka guftagu (GFT)-based E3 ubiquitin ligase complex, leading to degradation of active nuclear CI.", "reactants": [ "species_216110", "species_216104", "species_205911" ], "products": [ "species_216204" ], "modifiers": [ [ "species_216104", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VFP2", "rdx", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "Q9VFP2", "rdx", "P19538", "ci", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VFP2", "rdx", "Q9V475", "GFT", "Q9NHX0", "ROC1B" ] }, "reaction_216282": { "compartment": "compartment_7660", "id": "reaction_216282", "reactome": "R-DME-216282", "name": "Ubiquitinated CI is degraded by the proteasome complex", "reversible": "false", "notes": "The ubiquitinated Cubitus Interruptus (CI) is marked for degradation in the nucleus by the 26S proteasome complex.", "reactants": [ "species_216204" ], "products": [ "species_216110", "species_216104" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "Q9VFP2", "rdx", "P19538", "ci", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VFP2", "rdx", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_10497363": { "compartment": "compartment_17963", "id": "reaction_10497363", "reactome": "R-DME-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9604808", "species_735682" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10497360", "catalyst" ] ], "additional_components": [ "Q24157", "FBgn0000221", "A1Z8R4", "FBgn0050036", "A1Z8R5", "FBgn0050037", "A1Z8R6", "FBgn0053145", "Q95RP8", "FBgn0040373", "Q9VLS8", "FBgn0031988", "Q9VZA6", "FBgn0035558", "Q9VLT0", "FBgn0031986" ] }, "reaction_10439963": { "compartment": "compartment_70101", "id": "reaction_10439963", "reactome": "R-DME-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10439960", "catalyst" ] ], "additional_components": [ "P14773", "FBgn0263782" ] }, "reaction_10439993": { "compartment": "compartment_70101", "id": "reaction_10439993", "reactome": "R-DME-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29372", "species_29370", "species_113528", "species_191362" ], "modifiers": [ [ "species_10439990", "catalyst" ] ], "additional_components": [ "Q9VXQ3", "FBgn0030683" ] }, "reaction_10440468": { "compartment": "compartment_70101", "id": "reaction_10440468", "reactome": "R-DME-194698", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_194644", "species_29364" ], "products": [ "species_194633", "species_29366" ], "modifiers": [ [ "species_10440465", "catalyst" ] ], "additional_components": [ "FBgn0034657" ] }, "reaction_10487854": { "compartment": "compartment_70101", "id": "reaction_10487854", "reactome": "R-DME-8848215", "name": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_191293", "species_29356", "species_76194" ], "modifiers": [ [ "species_10487851", "catalyst" ] ], "additional_components": [ "Q9W0H6", "FBgn0035203" ] }, "reaction_10439953": { "compartment": "compartment_70101", "id": "reaction_10439953", "reactome": "R-DME-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_76183" ], "products": [ "species_29356", "species_191374", "species_76194" ], "modifiers": [ [ "species_10439950", "catalyst" ] ], "additional_components": [ "FBgn0010611" ] }, "reaction_10439983": { "compartment": "compartment_70101", "id": "reaction_10439983", "reactome": "R-DME-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10439980", "catalyst" ] ], "additional_components": [ "Q9VDC2", "FBgn0038876", "species_29926" ] }, "reaction_10440463": { "compartment": "compartment_13231", "id": "reaction_10440463", "reactome": "R-DME-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194725", "species_194688" ], "products": [ "species_194668", "species_194704" ], "modifiers": [ [ "species_10440460", "catalyst" ] ], "additional_components": [ "FBgn0034657" ] }, "reaction_10439948": { "compartment": "compartment_70101", "id": "reaction_10439948", "reactome": "R-DME-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10439942", "catalyst" ] ], "additional_components": [ "species_29926", "Q7KN61", "FBgn0025373", "Q9VS54", "FBgn0019662" ] }, "reaction_10439945": { "compartment": "compartment_70101", "id": "reaction_10439945", "reactome": "R-DME-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10439942", "catalyst" ] ], "additional_components": [ "species_29926", "Q7KN61", "FBgn0025373", "Q9VS54", "FBgn0019662" ] }, "reaction_10471177": { "compartment": "compartment_17957", "id": "reaction_10471177", "reactome": "R-DME-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10471174", "catalyst" ] ], "additional_components": [ "FBgn0052442" ] }, "reaction_10493848": { "compartment": "compartment_70101", "id": "reaction_10493848", "reactome": "R-DME-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10493845", "catalyst" ] ], "additional_components": [ "FBgn0051717" ] }, "reaction_10439973": { "compartment": "compartment_70101", "id": "reaction_10439973", "reactome": "R-DME-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10439970", "catalyst" ] ], "additional_components": [ "Q7K2V9", "FBgn0061359" ] }, "reaction_10440001": { "compartment": "compartment_70101", "id": "reaction_10440001", "reactome": "R-DME-191422", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191296" ], "products": [ "species_29370", "species_191403" ], "modifiers": [ [ "species_10439998", "catalyst" ] ], "additional_components": [ "FBgn0032811" ] }, "reaction_10429104": { "compartment": "compartment_70101", "id": "reaction_10429104", "reactome": "R-DME-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10429101", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "O77460", "FBgn0016687" ] }, "reaction_10458157": { "compartment": "compartment_7660", "id": "reaction_10458157", "reactome": "R-DME-1234172", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458144", "species_10458150" ], "products": [ "species_10437973", "species_10458154" ], "modifiers": [ [ "species_10458144", "catalyst" ] ], "additional_components": [ "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24167", "FBgn0266411", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411" ] }, "reaction_10458075": { "compartment": "compartment_70101", "id": "reaction_10458075", "reactome": "R-DME-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458071" ], "products": [ "species_10458073", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10458168": { "compartment": "compartment_70101", "id": "reaction_10458168", "reactome": "R-DME-1234183", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458032", "species_10458067" ], "products": [ "species_10458093" ], "modifiers": [], "additional_components": [ "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q24167", "FBgn0266411" ] }, "reaction_10458166": { "compartment": "compartment_7660", "id": "reaction_10458166", "reactome": "R-DME-1234181", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458085", "species_113671", "species_113685" ], "products": [ "species_10458134", "species_159942", "species_159939" ], "modifiers": [ [ "species_10458114", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "species_111793", "Q8SX21", "FBgn0264785", "species_351595" ] }, "reaction_10458117": { "compartment": "compartment_7660", "id": "reaction_10458117", "reactome": "R-DME-1234165", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458087", "species_113671", "species_113685" ], "products": [ "species_10458104", "species_159942", "species_159939" ], "modifiers": [ [ "species_10458114", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "species_111793", "Q8SX21", "FBgn0264785", "species_351595" ] }, "reaction_10458164": { "compartment": "compartment_70101", "id": "reaction_10458164", "reactome": "R-DME-1234177", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29368", "species_10458079" ], "products": [ "species_10458036", "species_29434", "species_113528" ], "modifiers": [ [ "species_10458067", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530" ] }, "reaction_10458146": { "compartment": "compartment_7660", "id": "reaction_10458146", "reactome": "R-DME-1234169", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458132", "species_10458142" ], "products": [ "species_10458144" ], "modifiers": [], "additional_components": [ "FBgn0266411", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411" ] }, "reaction_10458162": { "compartment": "compartment_70101", "id": "reaction_10458162", "reactome": "R-DME-1234175", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458154" ], "products": [ "species_10458043" ], "modifiers": [], "additional_components": [ "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24167", "FBgn0266411", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956" ] }, "reaction_10458160": { "compartment": "compartment_70101", "id": "reaction_10458160", "reactome": "R-DME-1234173", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_10458081", "species_29368" ], "products": [ "species_29434", "species_113528", "species_10458039" ], "modifiers": [ [ "species_10458067", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530" ] }, "reaction_10458096": { "compartment": "compartment_70101", "id": "reaction_10458096", "reactome": "R-DME-1234163", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458091", "species_10458093" ], "products": [ "species_10458069", "species_10427563" ], "modifiers": [ [ "species_10458093", "catalyst" ] ], "additional_components": [ "Q9Y165", "FBgn0027609", "P25867", "eff", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q24167", "FBgn0266411", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q24167", "FBgn0266411" ] }, "reaction_10479102": { "compartment": "compartment_5460", "id": "reaction_10479102", "reactome": "R-DME-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_5696194", "species_113573" ], "modifiers": [ [ "species_10479099", "catalyst" ] ], "additional_components": [ "FBgn0051713" ] }, "reaction_10468283": { "compartment": "compartment_984", "id": "reaction_10468283", "reactome": "R-DME-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_3299686" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10468280", "catalyst" ] ], "additional_components": [ "species_1562550", "species_209799", "P61851", "FBgn0003462" ] }, "reaction_10468411": { "compartment": "compartment_70101", "id": "reaction_10468411", "reactome": "R-DME-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_29408" ], "products": [ "species_10430994", "species_29356" ], "modifiers": [ [ "species_10468408", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "Q9V3P0", "FBgn0040309", "Q960M4", "FBgn0038570", "Q9VUM4", "FBgn0036490" ] }, "reaction_10468378": { "compartment": "compartment_70616", "id": "reaction_10468378", "reactome": "R-DME-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10436150" ], "products": [ "species_10436148", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "P84029", "FBgn0284248", "CHEBI:38573", "P84029", "FBgn0284248" ] }, "reaction_10470231": { "compartment": "compartment_17963", "id": "reaction_10470231", "reactome": "R-DME-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470229" ], "products": [ "species_10468280" ], "modifiers": [], "additional_components": [ "species_1562550", "species_209799", "P61851", "FBgn0003462", "species_1562550", "species_209799", "P61851", "FBgn0003462" ] }, "reaction_10468372": { "compartment": "compartment_5460", "id": "reaction_10468372", "reactome": "R-DME-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468350", "species_1614617" ], "products": [ "species_10468353", "species_113521" ], "modifiers": [ [ "species_10468369", "catalyst" ] ], "additional_components": [ "FBgn0035334", "FBgn0035334", "Q960M4", "FBgn0038570", "Q9VEJ0", "FBgn0038519" ] }, "reaction_10486317": { "compartment": "compartment_12045", "id": "reaction_10486317", "reactome": "R-DME-6807557", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_70106", "species_1222424", "species_29366" ], "modifiers": [ [ "species_10486314", "catalyst" ] ], "additional_components": [ "FBgn0085428" ] }, "reaction_10468272": { "compartment": "compartment_5460", "id": "reaction_10468272", "reactome": "R-DME-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_3299683" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10468269", "catalyst" ] ], "additional_components": [ "Q00637", "FBgn0010213", "species_266099" ] }, "reaction_10432650": { "compartment": "compartment_17951", "id": "reaction_10432650", "reactome": "R-DME-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_113535", "species_141343" ], "modifiers": [ [ "species_10432647", "catalyst" ] ], "additional_components": [ "species_71185", "species_29364", "P17336", "FBgn0000261" ] }, "reaction_10468778": { "compartment": "compartment_5460", "id": "reaction_10468778", "reactome": "R-DME-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468350", "species_3697881" ], "products": [ "species_10468353", "species_3697842", "species_113521" ], "modifiers": [ [ "species_10468367", "catalyst" ] ], "additional_components": [ "FBgn0035334", "FBgn0035334", "FBgn0038570" ] }, "reaction_10468775": { "compartment": "compartment_70101", "id": "reaction_10468775", "reactome": "R-DME-3697882", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_1222481" ], "products": [ "species_10430994", "species_29356", "species_1222379" ], "modifiers": [ [ "species_10468406", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "FBgn0038570" ] }, "reaction_10468293": { "compartment": "compartment_70101", "id": "reaction_10468293", "reactome": "R-DME-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10468290", "catalyst" ] ], "additional_components": [ "P61851", "FBgn0003462", "species_1562550", "species_209799" ] }, "reaction_10431013": { "compartment": "compartment_70101", "id": "reaction_10431013", "reactome": "R-DME-73646", "name": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430994", "species_70106", "species_29364" ], "products": [ "species_10430996", "species_29366" ], "modifiers": [ [ "species_10431010", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "species_113596", "Q9VNT5", "FBgn0037170", "P91938", "FBgn0020653" ] }, "reaction_10468833": { "compartment": "compartment_17927", "id": "reaction_10468833", "reactome": "R-DME-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10468830", "catalyst" ] ], "additional_components": [ "species_209799", "species_1562550", "P61851", "FBgn0003462" ] }, "reaction_10461593": { "compartment": "compartment_70101", "id": "reaction_10461593", "reactome": "R-DME-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10461590", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "species_74016", "P13217", "FBgn0262738" ] }, "reaction_10461704": { "compartment": "compartment_70101", "id": "reaction_10461704", "reactome": "R-DME-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10461569", "catalyst" ] ], "additional_components": [ "M9PHS8", "FBgn0030761", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10461652": { "compartment": "compartment_70101", "id": "reaction_10461652", "reactome": "R-DME-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_114520" ], "modifiers": [ [ "species_10461649", "catalyst" ] ], "additional_components": [ "Q7KMQ6", "Pten", "species_29926" ] }, "reaction_10461698": { "compartment": "compartment_12045", "id": "reaction_10461698", "reactome": "R-DME-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10461695", "catalyst" ] ], "additional_components": [ "Q9VIF2", "FBgn0032923", "Q9VIE9", "FBgn0263050", "species_74016" ] }, "reaction_10461713": { "compartment": "compartment_876", "id": "reaction_10461713", "reactome": "R-DME-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10461710", "catalyst" ] ], "additional_components": [ "species_74016", "Q9VXH3", "FBgn0003416" ] }, "reaction_10461681": { "compartment": "compartment_876", "id": "reaction_10461681", "reactome": "R-DME-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10461676", "catalyst" ] ], "additional_components": [ "FBgn0023508" ] }, "reaction_10461472": { "compartment": "compartment_70101", "id": "reaction_10461472", "reactome": "R-DME-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114520" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10461469", "catalyst" ] ], "additional_components": [ "species_74016", "Q7KV26", "FBgn0283680", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VL83", "FBgn0032147" ] }, "reaction_10465533": { "compartment": "compartment_70101", "id": "reaction_10465533", "reactome": "R-DME-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10446639" ], "products": [ "species_10440860" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10484665": { "compartment": "compartment_70101", "id": "reaction_10484665", "reactome": "R-DME-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10484662", "catalyst" ] ], "additional_components": [ "Q9VMP9", "FBgn0031717" ] }, "reaction_10481369": { "compartment": "compartment_70101", "id": "reaction_10481369", "reactome": "R-DME-6798335", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800" ], "products": [ "species_6798337" ], "modifiers": [ [ "species_10481366", "catalyst" ] ], "additional_components": [ "Q9VAN7", "FBgn0014869", "Q8T8W6", "FBgn0038957", "Q9VGB6", "FBgn0011270" ] }, "reaction_10429145": { "compartment": "compartment_70101", "id": "reaction_10429145", "reactome": "R-DME-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10429142", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q9VWH7", "FBgn0027621" ] }, "reaction_10427841": { "compartment": "compartment_70101", "id": "reaction_10427841", "reactome": "R-DME-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10427838", "catalyst" ] ], "additional_components": [ "Q9VWH7", "FBgn0027621" ] }, "reaction_10428045": { "compartment": "compartment_70101", "id": "reaction_10428045", "reactome": "R-DME-70471", "name": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29512" ], "modifiers": [ [ "species_10428042", "catalyst" ] ], "additional_components": [ "P52029", "FBgn0003074" ] }, "reaction_10428013": { "compartment": "compartment_70101", "id": "reaction_10428013", "reactome": "R-DME-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10428010", "catalyst" ] ], "additional_components": [ "P29613", "FBgn0086355" ] }, "reaction_10429003": { "compartment": "compartment_70101", "id": "reaction_10429003", "reactome": "R-DME-71660", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29356", "species_29492" ], "modifiers": [ [ "species_10428103", "catalyst" ] ], "additional_components": [ "species_29926", "P15007", "FBgn0000579" ] }, "reaction_10429001": { "compartment": "compartment_70101", "id": "reaction_10429001", "reactome": "R-DME-71654", "name": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29728" ], "products": [ "species_30485" ], "modifiers": [ [ "species_10428883", "catalyst" ] ], "additional_components": [ "Q9VAN7", "FBgn0014869" ] }, "reaction_10428902": { "compartment": "compartment_70101", "id": "reaction_10428902", "reactome": "R-DME-71496", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014" ], "products": [ "species_29578", "species_75970" ], "modifiers": [ [ "species_10428897", "catalyst" ] ], "additional_components": [ "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064" ] }, "reaction_10427973": { "compartment": "compartment_70101", "id": "reaction_10427973", "reactome": "R-DME-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10427970", "catalyst" ] ], "additional_components": [ "Q7JYW9", "FBgn0001187", "Q9W330", "FBgn0001186", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710" ] }, "reaction_10429157": { "compartment": "compartment_70101", "id": "reaction_10429157", "reactome": "R-DME-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10428087", "catalyst" ] ], "additional_components": [ "species_29926", "Q01604", "FBgn0250906" ] }, "reaction_10495131": { "compartment": "compartment_70101", "id": "reaction_10495131", "reactome": "R-DME-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29800" ], "products": [ "species_70106", "species_8955759", "species_29728" ], "modifiers": [ [ "species_10427859", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z9V3", "FBgn0033969", "A1Z7P1", "FBgn0033377" ] }, "reaction_10428035": { "compartment": "compartment_70101", "id": "reaction_10428035", "reactome": "R-DME-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_30014", "species_29370" ], "modifiers": [ [ "species_10428032", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_76190", "inhibitor" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "P52034", "FBgn0003071" ] }, "reaction_10428003": { "compartment": "compartment_70101", "id": "reaction_10428003", "reactome": "R-DME-70449", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_29578", "species_29360" ], "products": [ "species_70106", "species_29800", "species_73473" ], "modifiers": [ [ "species_10428000", "catalyst" ] ], "additional_components": [ "P07486", "FBgn0001091", "Q7JY07", "FBgn0034173", "P07487", "FBgn0001092" ] }, "reaction_10429058": { "compartment": "compartment_70101", "id": "reaction_10429058", "reactome": "R-DME-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10429055", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_29358", "inhibitor" ], [ "species_30389", "inhibitor" ] ], "additional_components": [ "Q9VNZ9", "FBgn0037115", "Q9VFG4", "FBgn0038258", "Q9VVH0", "FBgn0036723", "Q9VD23", "FBgn0038952", "Q9VQH0", "FBgn0031462", "O62619", "FBgn0267385", "species_29926", "species_74126" ] }, "reaction_10437795": { "compartment": "compartment_13231", "id": "reaction_10437795", "reactome": "R-DME-170825", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437793" ], "products": [ "species_10427948" ], "modifiers": [], "additional_components": [ "Q9W330", "FBgn0001186", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710", "Q7JYW9", "FBgn0001187", "Q7JYW9", "FBgn0001187", "Q9W330", "FBgn0001186", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710" ] }, "reaction_10453164": { "compartment": "compartment_70101", "id": "reaction_10453164", "reactome": "R-DME-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10453161", "catalyst" ] ], "additional_components": [ "FBgn0286506" ] }, "reaction_10450486": { "compartment": "compartment_70101", "id": "reaction_10450486", "reactome": "R-DME-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10450481", "catalyst" ] ], "additional_components": [ "FBgn0036300" ] }, "reaction_10447638": { "compartment": "compartment_876", "id": "reaction_10447638", "reactome": "R-DME-419002", "name": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447632", "species_10442033", "species_10447634", "species_10447624" ], "products": [ "species_10447636" ], "modifiers": [], "additional_components": [ "P18824", "arm", "FBgn0262018", "FBgn0260799", "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q7PLI0", "FBgn0260799", "Q9VJB6", "FBgn0262018", "P18824", "arm" ] }, "reaction_10447616": { "compartment": "compartment_204883", "id": "reaction_10447616", "reactome": "R-DME-419001", "name": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442033", "species_140648" ], "products": [ "species_10447614" ], "modifiers": [], "additional_components": [ "FBgn0262018", "Q9VJB6", "FBgn0262018" ] }, "reaction_10449511": { "compartment": "compartment_70101", "id": "reaction_10449511", "reactome": "R-DME-432909", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443378", "species_10441643" ], "products": [ "species_10449509" ], "modifiers": [], "additional_components": [ "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "FBgn0013733", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657" ] }, "reaction_10449527": { "compartment": "compartment_984", "id": "reaction_10449527", "reactome": "R-DME-432956", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449523", "species_10449519" ], "products": [ "species_10449525" ], "modifiers": [], "additional_components": [ "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10450422": { "compartment": "compartment_984", "id": "reaction_10450422", "reactome": "R-DME-446089", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443411", "species_10450420" ], "products": [ "species_10449519" ], "modifiers": [], "additional_components": [ "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10450418": { "compartment": "compartment_70101", "id": "reaction_10450418", "reactome": "R-DME-446083", "name": "CD151 interacts with BP180 and the integrin alpha 6 subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449525", "species_10450414" ], "products": [ "species_10450416" ], "modifiers": [], "additional_components": [ "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "FBgn0043550", "Q8IQK9", "FBgn0043550", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10449180": { "compartment": "compartment_70101", "id": "reaction_10449180", "reactome": "R-DME-430341", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449176", "species_10449164" ], "products": [ "species_10449178" ], "modifiers": [], "additional_components": [ "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688", "FBgn0011642", "Q9N675", "FBgn0011642", "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688" ] }, "reaction_10450586": { "compartment": "compartment_70101", "id": "reaction_10450586", "reactome": "R-DME-446391", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450580", "species_10450582", "species_10449503" ], "products": [ "species_10450584" ], "modifiers": [], "additional_components": [ "FBgn0028427", "Q9V400", "FBgn0028427", "Q8INQ9", "FBgn0020249" ] }, "reaction_10449507": { "compartment": "compartment_70101", "id": "reaction_10449507", "reactome": "R-DME-432897", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441029", "species_10449503" ], "products": [ "species_10449505" ], "modifiers": [], "additional_components": [ "FBgn0004657", "FBgn0028427", "Q9V400", "FBgn0028427", "P11584", "FBgn0004657" ] }, "reaction_10450563": { "compartment": "compartment_70101", "id": "reaction_10450563", "reactome": "R-DME-446322", "name": "PARVA associates with Paxillin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450559", "species_10438879" ], "products": [ "species_10450561" ], "modifiers": [], "additional_components": [ "FBgn0052528", "FBgn0041789", "Q9VWD0", "FBgn0052528", "Q2PDT4", "FBgn0041789" ] }, "reaction_10450567": { "compartment": "compartment_70101", "id": "reaction_10450567", "reactome": "R-DME-446364", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448617", "species_10449164" ], "products": [ "species_10450565" ], "modifiers": [], "additional_components": [ "FBgn0011642", "Q9N675", "FBgn0011642", "Q8T4F7", "ena" ] }, "reaction_10449188": { "compartment": "compartment_70101", "id": "reaction_10449188", "reactome": "R-DME-430347", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449184", "species_10449131", "species_10449164" ], "products": [ "species_10449186" ], "modifiers": [], "additional_components": [ "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "FBgn0014141", "FBgn0011642", "Q9N675", "FBgn0011642", "Q9VEN1", "FBgn0014141", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592" ] }, "reaction_10449515": { "compartment": "compartment_70101", "id": "reaction_10449515", "reactome": "R-DME-432946", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449141", "species_10442520" ], "products": [ "species_10449513" ], "modifiers": [], "additional_components": [ "FBgn0052528", "FBgn0015803", "A8DZ19", "FBgn0015803", "Q9VWD0", "FBgn0052528" ] }, "reaction_10449145": { "compartment": "compartment_70101", "id": "reaction_10449145", "reactome": "R-DME-430308", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449136", "species_10449141" ], "products": [ "species_10449143" ], "modifiers": [], "additional_components": [ "FBgn0000667", "FBgn0052528", "Q9VWD0", "FBgn0052528", "P18091", "FBgn0000667" ] }, "reaction_10449159": { "compartment": "compartment_70101", "id": "reaction_10449159", "reactome": "R-DME-430311", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449155", "species_10449150" ], "products": [ "species_10449157" ], "modifiers": [], "additional_components": [ "FBgn0020249", "FBgn0028546", "Q9V428", "FBgn0028546", "Q8INQ9", "FBgn0020249" ] }, "reaction_10450576": { "compartment": "compartment_70101", "id": "reaction_10450576", "reactome": "R-DME-446372", "name": "Association of PARVA with TESK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450572", "species_10450559" ], "products": [ "species_10450574" ], "modifiers": [], "additional_components": [ "FBgn0004876", "FBgn0052528", "Q9VWD0", "FBgn0052528", "Q9VE06", "FBgn0004876" ] }, "reaction_10444555": { "compartment": "compartment_876", "id": "reaction_10444555", "reactome": "R-DME-373732", "name": "Nephrin trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444454" ], "products": [ "species_10444456" ], "modifiers": [], "additional_components": [ "FBgn0024189", "Q0E9F2", "FBgn0024189" ] }, "reaction_10451625": { "compartment": "compartment_876", "id": "reaction_10451625", "reactome": "R-DME-451757", "name": "Heterodimerization of nephrin and KIRREL2, KIRREL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451621", "species_10444456" ], "products": [ "species_10451623" ], "modifiers": [], "additional_components": [ "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "A0A023GPK8", "FBgn0051774", "Q0E9F2", "FBgn0024189", "Q0E9F2", "FBgn0024189", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "A0A023GPK8", "FBgn0051774" ] }, "reaction_10495542": { "compartment": "compartment_876", "id": "reaction_10495542", "reactome": "R-DME-8981534", "name": "Nephrin dimer:KIRREL binds FYN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444480", "species_10444516" ], "products": [ "species_10444577" ], "modifiers": [], "additional_components": [ "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "FBgn0262733", "P00528", "FBgn0262733", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189" ] }, "reaction_10444566": { "compartment": "compartment_876", "id": "reaction_10444566", "reactome": "R-DME-373734", "name": "Nephrin interacts with Podocin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444528", "species_10444562" ], "products": [ "species_10444564" ], "modifiers": [], "additional_components": [ "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733", "Q9VZA4", "FBgn0260657", "Q9VZA4", "FBgn0260657", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733" ] }, "reaction_10444580": { "compartment": "compartment_876", "id": "reaction_10444580", "reactome": "R-DME-373747", "name": "Phosphorylation of nephrin by FYN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444577", "species_113592" ], "products": [ "species_10444528", "species_29370" ], "modifiers": [ [ "species_10444577", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189" ] }, "reaction_10444532": { "compartment": "compartment_876", "id": "reaction_10444532", "reactome": "R-DME-373724", "name": "Nephrin binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444528", "species_10444486" ], "products": [ "species_10444530" ], "modifiers": [], "additional_components": [ "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733", "Q9VPU1", "dock", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733" ] }, "reaction_10444482": { "compartment": "compartment_876", "id": "reaction_10444482", "reactome": "R-DME-373714", "name": "Cis-Heterodimerization of nephrin and KIRREL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444456", "species_10444478" ], "products": [ "species_10444480" ], "modifiers": [], "additional_components": [ "Q0E9F2", "FBgn0024189", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189" ] }, "reaction_10484751": { "compartment": "compartment_70101", "id": "reaction_10484751", "reactome": "R-DME-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484729", "species_71284" ], "products": [ "species_10484736", "species_71285" ], "modifiers": [ [ "species_10484748", "catalyst" ] ], "additional_components": [ "Q9VPH7", "FBgn0036974", "Q9VK85", "FBgn0020443", "species_29438", "Q9VPH7", "FBgn0036974", "Q9VK85", "FBgn0020443", "species_29438", "Q9VP65", "FBgn0037061", "Q9VQF8", "FBgn0031454" ] }, "reaction_10469966": { "compartment": "compartment_70101", "id": "reaction_10469966", "reactome": "R-DME-4608854", "name": "SMURF1/2 are recruited to the DVL2:PARD6A complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469940", "species_10437960" ], "products": [ "species_10469961" ], "modifiers": [], "additional_components": [ "O97111", "FBgn0026192", "P51140", "phospho-dsh", "FBgn0029006", "Q9V853", "FBgn0029006", "O97111", "FBgn0026192", "P51140", "phospho-dsh" ] }, "reaction_10469964": { "compartment": "compartment_70101", "id": "reaction_10469964", "reactome": "R-DME-4608852", "name": "SMURF1/2 ubiquitinates PRICKLE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10469951" ], "products": [ "species_10469959" ], "modifiers": [ [ "species_10469961", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9U1I1", "FBgn0263934", "A1Z6W3", "PK", "Q9U1I1", "FBgn0263934", "A1Z6W3", "PK", "Q9V853", "FBgn0029006", "O97111", "FBgn0026192", "P51140", "phospho-dsh" ] }, "reaction_10470337": { "compartment": "compartment_876", "id": "reaction_10470337", "reactome": "R-DME-5099886", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470333", "species_10468078" ], "products": [ "species_10470335" ], "modifiers": [], "additional_components": [ "Q9VVX3", "FZ2", "FBgn0010194", "P28466", "FBgn0010194", "Q9VVX3", "FZ2" ] }, "reaction_10469968": { "compartment": "compartment_70101", "id": "reaction_10469968", "reactome": "R-DME-4608855", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469959" ], "products": [], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9U1I1", "FBgn0263934", "A1Z6W3", "PK", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10456021": { "compartment": "compartment_20699", "id": "reaction_10456021", "reactome": "R-DME-977228", "name": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_10454862" ], "products": [ "species_10456019", "species_727810" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "FBgn0035050" ] }, "reaction_10456000": { "compartment": "compartment_17963", "id": "reaction_10456000", "reactome": "R-DME-977071", "name": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454561", "species_727815" ], "products": [ "species_727810", "species_10455998" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "FBgn0035050" ] }, "reaction_10463326": { "compartment": "compartment_984", "id": "reaction_10463326", "reactome": "R-DME-2022399", "name": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10444709" ], "products": [ "species_10463316" ], "modifiers": [ [ "species_10463323", "catalyst" ] ], "additional_components": [ "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "Q9VFX0", "FBgn0038135" ] }, "reaction_10463254": { "compartment": "compartment_984", "id": "reaction_10463254", "reactome": "R-DME-2022398", "name": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463066" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463251", "catalyst" ] ], "additional_components": [ "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10497644": { "compartment": "compartment_984", "id": "reaction_10497644", "reactome": "R-DME-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10478126", "catalyst" ] ], "additional_components": [ "P23654", "FBgn0004108" ] }, "reaction_10497585": { "compartment": "compartment_984", "id": "reaction_10497585", "reactome": "R-DME-9614933", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464707", "species_9614913" ], "products": [ "species_10464710" ], "modifiers": [], "additional_components": [ "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10463500": { "compartment": "compartment_984", "id": "reaction_10463500", "reactome": "R-DME-2022412", "name": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463388" ], "products": [ "species_10463198" ], "modifiers": [ [ "species_10463497", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q7K485", "FBgn0029093", "Q9VQ13", "FBgn0051926", "A1Z9Q9", "FBgn0033933", "Q9VQ12", "FBgn0053128", "Q9VQ11", "FBgn0051928", "Q9VLK3", "FBgn0032049", "Q9VKP7", "FBgn0032303", "Q9VKP6", "FBgn0032304", "Q9VEK4", "FBgn0038506", "Q9W5G3", "FBgn0011822", "Q9VEK3", "FBgn0038507", "Q9VQ14", "FBgn0053128" ] }, "reaction_10463467": { "compartment": "compartment_984", "id": "reaction_10463467", "reactome": "R-DME-2022405", "name": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10444709" ], "modifiers": [ [ "species_10463251", "catalyst" ], [ "species_188972", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10463464": { "compartment": "compartment_984", "id": "reaction_10463464", "reactome": "R-DME-2022403", "name": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463388" ], "products": [ "species_10463198" ], "modifiers": [ [ "species_10463461", "catalyst" ], [ "species_10463461", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VKP7", "FBgn0032303", "Q9VQ12", "FBgn0053128", "Q9W5G3", "FBgn0011822", "Q7K485", "FBgn0029093", "Q9VKP6", "FBgn0032304", "Q9VQ11", "FBgn0051928", "Q9VQ14", "FBgn0053128", "A1Z9Q9", "FBgn0033933", "Q9VEK4", "FBgn0038506", "Q9VLK3", "FBgn0032049", "Q9VQ13", "FBgn0051926", "Q9VEK3", "FBgn0038507", "Q9VHG4", "FBgn0037671", "Q9VKP7", "FBgn0032303", "Q9VQ12", "FBgn0053128", "Q9W5G3", "FBgn0011822", "Q7K485", "FBgn0029093", "Q9VKP6", "FBgn0032304", "Q9VQ11", "FBgn0051928", "Q9VQ14", "FBgn0053128", "A1Z9Q9", "FBgn0033933", "Q9VEK4", "FBgn0038506", "Q9VLK3", "FBgn0032049", "Q9VQ13", "FBgn0051926", "Q9VEK3", "FBgn0038507", "Q9VHG4", "FBgn0037671" ] }, "reaction_10464744": { "compartment": "compartment_984", "id": "reaction_10464744", "reactome": "R-DME-2065357", "name": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463388" ], "products": [ "species_10463198" ], "modifiers": [ [ "species_10464741", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VEK3", "FBgn0038507", "Q9VQ14", "FBgn0053128", "Q7K485", "FBgn0029093", "Q9VQ13", "FBgn0051926", "A1Z9Q9", "FBgn0033933", "Q9VQ12", "FBgn0053128", "Q9VQ11", "FBgn0051928", "Q9VLK3", "FBgn0032049", "Q9VKP7", "FBgn0032303", "Q9VKP6", "FBgn0032304", "Q9VEK4", "FBgn0038506", "Q9W5G3", "FBgn0011822", "Q9VHG4", "FBgn0037671" ] }, "reaction_10464712": { "compartment": "compartment_984", "id": "reaction_10464712", "reactome": "R-DME-2065355", "name": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10444709" ], "modifiers": [ [ "species_10464707", "catalyst" ], [ "species_188972", "catalyst" ], [ "species_10464710", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10463237": { "compartment": "compartment_984", "id": "reaction_10463237", "reactome": "R-DME-2022396", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463133", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "FBgn0031081" ] }, "reaction_10463235": { "compartment": "compartment_984", "id": "reaction_10463235", "reactome": "R-DME-2022379", "name": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10444709" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463230", "catalyst" ] ], "additional_components": [ "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "Q8SXX2", "FBgn0032536", "Q9W0Z1", "FBgn0035076", "Q10714", "FBgn0012037", "Q9VLJ6", "FBgn0016122", "A1Z7M8", "FBgn0033366", "Q9VJV2", "FBgn0032535" ] }, "reaction_10463233": { "compartment": "compartment_984", "id": "reaction_10463233", "reactome": "R-DME-2022378", "name": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10463066" ], "modifiers": [ [ "species_10463230", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "Q8SXX2", "FBgn0032536", "Q9W0Z1", "FBgn0035076", "Q10714", "FBgn0012037", "Q9VLJ6", "FBgn0016122", "A1Z7M8", "FBgn0033366", "Q9VJV2", "FBgn0032535" ] }, "reaction_10464257": { "compartment": "compartment_984", "id": "reaction_10464257", "reactome": "R-DME-2028294", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10463066" ], "modifiers": [ [ "species_10464254", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "Q961J8", "FBgn0035781", "Q9VRZ3", "FBgn0035718", "Q9VX86", "FBgn0030815", "Q7JYV3", "FBgn0033774", "Q9VLZ2", "FBgn0031929", "Q9VS80", "FBgn0035791", "Q0E9F9", "FBgn0033241", "Q9VLZ1", "FBgn0031930", "Q9VS67", "FBgn0035780", "M9PEV1", "FBgn0035776", "Q9VL87", "FBgn0032143", "Q9VS66", "FBgn0035779", "Q9W478", "FBgn0029804", "Q9VL86", "FBgn0032144", "Q9VS65", "FBgn0052379", "Q9W477", "FBgn0259149", "Q9VCM8", "FBgn0039073", "Q9VS64", "FBgn0035777", "Q9W475", "FBgn0029807" ] }, "reaction_10463136": { "compartment": "compartment_984", "id": "reaction_10463136", "reactome": "R-DME-2022368", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463066" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463133", "catalyst" ] ], "additional_components": [ "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "FBgn0031081" ] }, "reaction_209224": { "compartment": "compartment_70101", "id": "reaction_209224", "reactome": "R-DME-209224", "name": "SLMB binds to and ubiquitinates phosphorylated CI", "reversible": "false", "notes": "Phosphorylated Cubitus Interruptus (CI) is now recognised by Slimb (SLMB), which is part of the SCF (Skp1, Cdc53, and F-box) ubiquitin ligase complex. CI associates with SLMB via its phosphorylated residues and is then ubiquitinated by the SCF ubiquitin ligase complex.", "reactants": [ "species_206204", "species_206766", "species_206788" ], "products": [ "species_207011" ], "modifiers": [ [ "species_207002", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209278": { "compartment": "compartment_70101", "id": "reaction_209278", "reactome": "R-DME-209278", "name": "Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex", "reversible": "false", "notes": "Ubiquitinated and phosphorylated Cubitus Interruptus (CI) is processed by the proteasome complex resulting in a truncated product, CI75, with a C-terminus somewhere between residues 650-700 (Aza-Blanc et al., 1997) or 611-760 (Methot and Basler, 1999). It is thought that the zinc-finger domain and C-terminal simple sequences arrest proteasome digestion from the C-terminus. Some CI is likely to be fully proteolysed by the proteasome.", "reactants": [ "species_207011" ], "products": [ "species_206204", "species_206171", "species_206788", "species_206900" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_10475099": { "compartment": "compartment_70101", "id": "reaction_10475099", "reactome": "R-DME-5654647", "name": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475094", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475096": { "compartment": "compartment_876", "id": "reaction_10475096", "reactome": "R-DME-5654646", "name": "Activated FGFR3:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475085" ], "products": [ "species_10475094" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475073": { "compartment": "compartment_70101", "id": "reaction_10475073", "reactome": "R-DME-5654625", "name": "Activated FGFR3 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465477", "species_10474909" ], "products": [ "species_10475071" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475088": { "compartment": "compartment_70101", "id": "reaction_10475088", "reactome": "R-DME-5654634", "name": "Activated FGFR3 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475071" ], "products": [ "species_29370", "species_10475085" ], "modifiers": [ [ "species_10475071", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475069": { "compartment": "compartment_70101", "id": "reaction_10475069", "reactome": "R-DME-5654623", "name": "Activated FGFR3 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474997", "species_10465477" ], "products": [ "species_10475067" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474925": { "compartment": "compartment_876", "id": "reaction_10474925", "reactome": "R-DME-5654408", "name": "Activated FGFR3 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474920" ], "products": [ "species_29370", "species_10465479" ], "modifiers": [ [ "species_10474920", "catalyst" ], [ "species_10474923", "inhibitor" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474939": { "compartment": "compartment_70101", "id": "reaction_10474939", "reactome": "R-DME-5654416", "name": "Activated FGFR3:pFRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474932", "species_10431797" ], "products": [ "species_10474934" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475083": { "compartment": "compartment_876", "id": "reaction_10475083", "reactome": "R-DME-5654631", "name": "Activated FGFR3 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475078" ], "products": [ "species_29370", "species_10475080" ], "modifiers": [ [ "species_10475078", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474937": { "compartment": "compartment_70101", "id": "reaction_10474937", "reactome": "R-DME-5654413", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474934", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10493208": { "compartment": "compartment_70101", "id": "reaction_10493208", "reactome": "R-DME-8941628", "name": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475080", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475076": { "compartment": "compartment_876", "id": "reaction_10475076", "reactome": "R-DME-5654628", "name": "Activated FGFR3 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475067" ], "products": [ "species_10474930", "species_29370" ], "modifiers": [ [ "species_10475067", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474928": { "compartment": "compartment_70101", "id": "reaction_10474928", "reactome": "R-DME-5654409", "name": "Activated FGFR3 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465477", "species_10474873" ], "products": [ "species_10474920" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474855": { "compartment": "compartment_876", "id": "reaction_10474855", "reactome": "R-DME-5654224", "name": "Activated FGFR3 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10465477", "species_10439290" ], "products": [ "species_10474850" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0003416", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_179838" ] }, "reaction_10474822": { "compartment": "compartment_876", "id": "reaction_10474822", "reactome": "R-DME-5654148", "name": "p-4Y-PLCG1 dissociates from activated FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474820" ], "products": [ "species_10465477", "species_10441915" ], "modifiers": [], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0003416" ] }, "reaction_10474853": { "compartment": "compartment_70101", "id": "reaction_10474853", "reactome": "R-DME-5654222", "name": "Activated FGFR3 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474850", "species_113592" ], "products": [ "species_10474820", "species_29370" ], "modifiers": [ [ "species_10474850", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_179838", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_179838" ] }, "reaction_10475180": { "compartment": "compartment_70101", "id": "reaction_10475180", "reactome": "R-DME-5654709", "name": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465509", "catalyst" ] ], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475177": { "compartment": "compartment_70101", "id": "reaction_10475177", "reactome": "R-DME-5654705", "name": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465483", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475092": { "compartment": "compartment_70101", "id": "reaction_10475092", "reactome": "R-DME-5654641", "name": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465505", "species_10438945" ], "products": [ "species_10465507" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475090": { "compartment": "compartment_70101", "id": "reaction_10475090", "reactome": "R-DME-5654637", "name": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465479" ], "products": [ "species_10465481" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10488437": { "compartment": "compartment_17963", "id": "reaction_10488437", "reactome": "R-DME-8851619", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10488432" ], "products": [ "species_205687", "species_10488434" ], "modifiers": [ [ "species_10454602", "catalyst" ] ], "additional_components": [ "FBgn0014135", "FBgn0014135", "FBgn0034025" ] }, "reaction_10488439": { "compartment": "compartment_17963", "id": "reaction_10488439", "reactome": "R-DME-8851632", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488434" ], "products": [ "species_10433476" ], "modifiers": [], "additional_components": [ "FBgn0014135", "FBgn0014135" ] }, "reaction_10439768": { "compartment": "compartment_876", "id": "reaction_10439768", "reactome": "R-DME-190388", "name": "Autocatalytic phosphorylation of FGFR3c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439729", "species_113592" ], "products": [ "species_29370", "species_10433592" ], "modifiers": [ [ "species_10439729", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439731": { "compartment": "compartment_984", "id": "reaction_10439731", "reactome": "R-DME-190261", "name": "FGFR3c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433467", "species_10439725", "species_190915" ], "products": [ "species_10439729" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439743": { "compartment": "compartment_984", "id": "reaction_10439743", "reactome": "R-DME-190263", "name": "FGFR3b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439737", "species_190915", "species_10433471" ], "products": [ "species_10439741" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10439765": { "compartment": "compartment_876", "id": "reaction_10439765", "reactome": "R-DME-190385", "name": "Autocatalytic phosphorylation of FGFR3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439741" ], "products": [ "species_29370", "species_10433573" ], "modifiers": [ [ "species_10439741", "catalyst" ] ], "additional_components": [ "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "species_190915", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474991": { "compartment": "compartment_70101", "id": "reaction_10474991", "reactome": "R-DME-5654565", "name": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474920" ], "products": [ "species_29370", "species_10474923" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "P40417", "FBgn0003256" ] }, "reaction_10475192": { "compartment": "compartment_70101", "id": "reaction_10475192", "reactome": "R-DME-5654730", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465505", "species_10439154" ], "products": [ "species_10475150" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475155": { "compartment": "compartment_70101", "id": "reaction_10475155", "reactome": "R-DME-5654679", "name": "CBL ubiquitinates FRS2 and FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10475150" ], "products": [ "species_10475152" ], "modifiers": [ [ "species_10475150", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10439771": { "compartment": "compartment_876", "id": "reaction_10439771", "reactome": "R-DME-190408", "name": "Autocatalytic phosphorylation of FGFR2b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439717", "species_113592" ], "products": [ "species_29370", "species_10433531" ], "modifiers": [ [ "species_10439717", "catalyst" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439719": { "compartment": "compartment_876", "id": "reaction_10439719", "reactome": "R-DME-190260", "name": "FGFR2b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433429", "species_10439670", "species_190915" ], "products": [ "species_10439717" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0014135", "FBgn0285896", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439774": { "compartment": "compartment_876", "id": "reaction_10439774", "reactome": "R-DME-190413", "name": "Autocatalytic phosphorylation of FGFR2c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439703" ], "products": [ "species_10433553", "species_29370" ], "modifiers": [ [ "species_10439703", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896" ] }, "reaction_10439705": { "compartment": "compartment_876", "id": "reaction_10439705", "reactome": "R-DME-190258", "name": "FGFR2c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439691", "species_10433467", "species_190915" ], "products": [ "species_10439703" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0285896", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896" ] }, "reaction_10475065": { "compartment": "compartment_876", "id": "reaction_10475065", "reactome": "R-DME-5654620", "name": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465499" ], "products": [ "species_10465501" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475174": { "compartment": "compartment_70101", "id": "reaction_10475174", "reactome": "R-DME-5654701", "name": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465475", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475171": { "compartment": "compartment_70101", "id": "reaction_10475171", "reactome": "R-DME-5654697", "name": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465503", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475056": { "compartment": "compartment_876", "id": "reaction_10475056", "reactome": "R-DME-5654612", "name": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465471" ], "products": [ "species_10465473" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475054": { "compartment": "compartment_876", "id": "reaction_10475054", "reactome": "R-DME-5654607", "name": "Activated FGFR2 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475049" ], "products": [ "species_29370", "species_10475051" ], "modifiers": [ [ "species_10475049", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474893": { "compartment": "compartment_70101", "id": "reaction_10474893", "reactome": "R-DME-5654399", "name": "Activated FGFR2 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474873", "species_10465469" ], "products": [ "species_10474875" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042" ] }, "reaction_10493202": { "compartment": "compartment_70101", "id": "reaction_10493202", "reactome": "R-DME-8941618", "name": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475051", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474890": { "compartment": "compartment_876", "id": "reaction_10474890", "reactome": "R-DME-5654397", "name": "Activated FGFR2 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474875" ], "products": [ "species_29370", "species_10465471" ], "modifiers": [ [ "species_10474875", "catalyst" ], [ "species_10474888", "inhibitor" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475063": { "compartment": "compartment_70101", "id": "reaction_10475063", "reactome": "R-DME-5654618", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475058", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475060": { "compartment": "compartment_70101", "id": "reaction_10475060", "reactome": "R-DME-5654615", "name": "Activated FGFR2:pFRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475047" ], "products": [ "species_10475058" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474907": { "compartment": "compartment_70101", "id": "reaction_10474907", "reactome": "R-DME-5654402", "name": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474904", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474918": { "compartment": "compartment_70101", "id": "reaction_10474918", "reactome": "R-DME-5654407", "name": "Activated FGFR2 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474911" ], "products": [ "species_29370", "species_10474902" ], "modifiers": [ [ "species_10474911", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474915": { "compartment": "compartment_876", "id": "reaction_10474915", "reactome": "R-DME-5654406", "name": "Activated FGFR2:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10474902" ], "products": [ "species_10474904" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474913": { "compartment": "compartment_70101", "id": "reaction_10474913", "reactome": "R-DME-5654404", "name": "Activated FGFR2 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474909", "species_10465469" ], "products": [ "species_10474911" ], "modifiers": [], "additional_components": [ "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474840": { "compartment": "compartment_876", "id": "reaction_10474840", "reactome": "R-DME-5654159", "name": "Activated FGFR2 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10439290", "species_10465469" ], "products": [ "species_10474813" ], "modifiers": [], "additional_components": [ "FBgn0003416", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474838": { "compartment": "compartment_876", "id": "reaction_10474838", "reactome": "R-DME-5654157", "name": "p-4Y-PLCG1 dissociates from activated FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474815" ], "products": [ "species_10441915", "species_10465469" ], "modifiers": [], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "FBgn0003416", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474818": { "compartment": "compartment_70101", "id": "reaction_10474818", "reactome": "R-DME-5654147", "name": "Activated FGFR2 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474813" ], "products": [ "species_29370", "species_10474815" ], "modifiers": [ [ "species_10474813", "catalyst" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_179838", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474989": { "compartment": "compartment_70101", "id": "reaction_10474989", "reactome": "R-DME-5654562", "name": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474875" ], "products": [ "species_29370", "species_10474888" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "P40417", "FBgn0003256" ] }, "reaction_10475148": { "compartment": "compartment_70101", "id": "reaction_10475148", "reactome": "R-DME-5654677", "name": "CBL ubiquitinates FRS2 and FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475143", "species_10426987" ], "products": [ "species_10475145" ], "modifiers": [ [ "species_10475143", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10475190": { "compartment": "compartment_70101", "id": "reaction_10475190", "reactome": "R-DME-5654729", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439154", "species_10465499" ], "products": [ "species_10475143" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10485933": { "compartment": "compartment_7660", "id": "reaction_10485933", "reactome": "R-DME-6803527", "name": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485901", "species_10485929", "species_10485927", "species_10485894", "species_10429340", "species_10485922" ], "products": [ "species_10485931" ], "modifiers": [], "additional_components": [ "Q9VGH5", "FBgn0259139", "Q9W0D6", "FBgn0035235", "M9NFQ7", "FBgn0052062", "FBgn0023441", "FBgn0023441", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "FBgn0267790", "A8JPX0", "FBgn0085383", "E1JIZ9", "FBgn0085391", "Q8IMX4", "FBgn0005649", "A8JPX0", "FBgn0085383", "E1JIZ9", "FBgn0085391", "Q8IMX4", "FBgn0005649", "Q9VHC7", "FBgn0267790", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9BJZ5", "FBgn0023441", "Q9VGH5", "FBgn0259139", "Q9W0D6", "FBgn0035235", "M9NFQ7", "FBgn0052062" ] }, "reaction_10474976": { "compartment": "compartment_876", "id": "reaction_10474976", "reactome": "R-DME-5654511", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433429", "species_10474972", "species_190915" ], "products": [ "species_10474974" ], "modifiers": [], "additional_components": [ "FBgn0014135", "Q9I7U4", "FBgn0086906", "species_190915", "Q9I7U4", "FBgn0086906", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474987": { "compartment": "compartment_70101", "id": "reaction_10474987", "reactome": "R-DME-5654560", "name": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474982" ], "products": [ "species_29370", "species_10474984" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "P40417", "FBgn0003256" ] }, "reaction_10475141": { "compartment": "compartment_70101", "id": "reaction_10475141", "reactome": "R-DME-5654673", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439154", "species_10465493" ], "products": [ "species_10475134" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10475139": { "compartment": "compartment_70101", "id": "reaction_10475139", "reactome": "R-DME-5654672", "name": "CBL ubiquitinates FRS2 and FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10475134" ], "products": [ "species_10475136" ], "modifiers": [ [ "species_10475134", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10474978": { "compartment": "compartment_876", "id": "reaction_10474978", "reactome": "R-DME-5654514", "name": "KAL1 binds FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439681", "species_10439672" ], "products": [ "species_10439683" ], "modifiers": [], "additional_components": [ "FBgn0039155", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VCC7", "FBgn0039155" ] }, "reaction_10439666": { "compartment": "compartment_984", "id": "reaction_10439666", "reactome": "R-DME-190245", "name": "FGFR1b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433429", "species_10439660", "species_190915" ], "products": [ "species_10439664" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439777": { "compartment": "compartment_876", "id": "reaction_10439777", "reactome": "R-DME-190427", "name": "Autocatalytic phosphorylation of FGFR1b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439664", "species_113592" ], "products": [ "species_29370", "species_10433465" ], "modifiers": [ [ "species_10439664", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "species_190915", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439687": { "compartment": "compartment_984", "id": "reaction_10439687", "reactome": "R-DME-190256", "name": "FGFR1c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439672", "species_10433467", "species_190915" ], "products": [ "species_10439676" ], "modifiers": [ [ "species_190915", "catalyst" ], [ "species_10439685", "catalyst" ], [ "species_10439683", "inhibitor" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VCC7", "FBgn0039155", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VCC7", "FBgn0039155" ] }, "reaction_10439780": { "compartment": "compartment_876", "id": "reaction_10439780", "reactome": "R-DME-190429", "name": "Autocatalytic phosphorylation of FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439676" ], "products": [ "species_29370", "species_10433484" ], "modifiers": [ [ "species_10439676", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474980": { "compartment": "compartment_984", "id": "reaction_10474980", "reactome": "R-DME-5654515", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439681", "species_190915" ], "products": [ "species_10439685" ], "modifiers": [], "additional_components": [ "FBgn0039155", "species_190915", "Q9VCC7", "FBgn0039155" ] }, "reaction_10439759": { "compartment": "compartment_984", "id": "reaction_10439759", "reactome": "R-DME-190268", "name": "FGFR1c binds to Klotho-bound FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439672", "species_190915", "species_10433503" ], "products": [ "species_10439757" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10439920": { "compartment": "compartment_876", "id": "reaction_10439920", "reactome": "R-DME-191062", "name": "Autocatalytic phosphorylation of Klotho-bound FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439757" ], "products": [ "species_10433505", "species_29370" ], "modifiers": [ [ "species_10439757", "catalyst" ] ], "additional_components": [ "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474846": { "compartment": "compartment_876", "id": "reaction_10474846", "reactome": "R-DME-5654167", "name": "Activated FGFR1 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10465461", "species_10439290" ], "products": [ "species_10474824" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0003416", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_179838" ] }, "reaction_10474829": { "compartment": "compartment_70101", "id": "reaction_10474829", "reactome": "R-DME-5654149", "name": "Activated FGFR1 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474824" ], "products": [ "species_29370", "species_10474826" ], "modifiers": [ [ "species_10474824", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_179838", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_179838" ] }, "reaction_10474844": { "compartment": "compartment_876", "id": "reaction_10474844", "reactome": "R-DME-5654165", "name": "p-4Y-PLCG1 dissociates from activated FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474826" ], "products": [ "species_10465461", "species_10441915" ], "modifiers": [], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0003416" ] }, "reaction_10475309": { "compartment": "compartment_876", "id": "reaction_10475309", "reactome": "R-DME-5656064", "name": "Activated FGFR1 binds FLRT1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475301", "species_10465461" ], "products": [ "species_10475307" ], "modifiers": [], "additional_components": [ "FBgn0028872", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "M9MSI4", "FBgn0028872", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475018": { "compartment": "compartment_70101", "id": "reaction_10475018", "reactome": "R-DME-5654586", "name": "Activated FGFR1:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474866", "species_10431797" ], "products": [ "species_10474868" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10493205": { "compartment": "compartment_70101", "id": "reaction_10493205", "reactome": "R-DME-8941623", "name": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475022", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475001": { "compartment": "compartment_70101", "id": "reaction_10475001", "reactome": "R-DME-5654571", "name": "Activated FGFR1 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465461", "species_10474997" ], "products": [ "species_10474999" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10474871": { "compartment": "compartment_70101", "id": "reaction_10474871", "reactome": "R-DME-5654392", "name": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474868", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10474995": { "compartment": "compartment_70101", "id": "reaction_10474995", "reactome": "R-DME-5654569", "name": "Activated FGFR1 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465461", "species_10474873" ], "products": [ "species_10474982" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475011": { "compartment": "compartment_876", "id": "reaction_10475011", "reactome": "R-DME-5654578", "name": "Activated FGFR1 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474999" ], "products": [ "species_10474864", "species_29370" ], "modifiers": [ [ "species_10474999", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475025": { "compartment": "compartment_876", "id": "reaction_10475025", "reactome": "R-DME-5654587", "name": "Activated FGFR1:p-FRS phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475020" ], "products": [ "species_29370", "species_10475022" ], "modifiers": [ [ "species_10475020", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475008": { "compartment": "compartment_876", "id": "reaction_10475008", "reactome": "R-DME-5654575", "name": "Activated FGFR1 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474982" ], "products": [ "species_29370", "species_10465463" ], "modifiers": [ [ "species_10474982", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475165": { "compartment": "compartment_70101", "id": "reaction_10475165", "reactome": "R-DME-5654690", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465467", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475029": { "compartment": "compartment_70101", "id": "reaction_10475029", "reactome": "R-DME-5654594", "name": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465493" ], "products": [ "species_10465495" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475027": { "compartment": "compartment_70101", "id": "reaction_10475027", "reactome": "R-DME-5654592", "name": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465463" ], "products": [ "species_10465465" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475168": { "compartment": "compartment_70101", "id": "reaction_10475168", "reactome": "R-DME-5654692", "name": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465497", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10459327": { "compartment": "compartment_876", "id": "reaction_10459327", "reactome": "R-DME-1470009", "name": "Phosphorylation of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10459159" ], "products": [ "species_29370", "species_10459324" ], "modifiers": [ [ "species_10459159", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop" ] }, "reaction_10498528": { "compartment": "compartment_876", "id": "reaction_10498528", "reactome": "R-DME-9681375", "name": "KIT binds ripretinib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442600", "species_9674322" ], "products": [ "species_10498526" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10498434": { "compartment": "compartment_876", "id": "reaction_10498434", "reactome": "R-DME-9669854", "name": "KIT binds type II TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9669722", "species_10442600" ], "products": [ "species_10498432" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10459164": { "compartment": "compartment_876", "id": "reaction_10459164", "reactome": "R-DME-1433471", "name": "Activation of RAS by p-KIT bound SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10442628", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10459161": { "compartment": "compartment_876", "id": "reaction_10459161", "reactome": "R-DME-1433456", "name": "Recruitment of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445861", "species_10459141" ], "products": [ "species_10459159" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop" ] }, "reaction_10459128": { "compartment": "compartment_70101", "id": "reaction_10459128", "reactome": "R-DME-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10459125", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "species_179838", "Q9NHV9", "FBgn0040068" ] }, "reaction_10459144": { "compartment": "compartment_876", "id": "reaction_10459144", "reactome": "R-DME-1433418", "name": "Phosphorylation of JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459136", "species_113592" ], "products": [ "species_29370", "species_10459141" ], "modifiers": [ [ "species_10459136", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop" ] }, "reaction_10459335": { "compartment": "compartment_876", "id": "reaction_10459335", "reactome": "R-DME-1470012", "name": "Disassociation and translocation of STATs to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459329" ], "products": [ "species_10458565", "species_10459141" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "Q24151", "Stat92E", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop" ] }, "reaction_10459157": { "compartment": "compartment_876", "id": "reaction_10459157", "reactome": "R-DME-1433423", "name": "PTP-RO interacts with p-c-Kit complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459153", "species_10442600" ], "products": [ "species_10459155" ], "modifiers": [], "additional_components": [ "Q9VJ95", "FBgn0267486", "A1ZAB3", "FBgn0034085", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ95", "FBgn0267486", "A1ZAB3", "FBgn0034085" ] }, "reaction_10459331": { "compartment": "compartment_876", "id": "reaction_10459331", "reactome": "R-DME-1470010", "name": "Dimerization of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459324" ], "products": [ "species_10459329" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop", "Q24151", "Stat92E", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop" ] }, "reaction_10459179": { "compartment": "compartment_876", "id": "reaction_10459179", "reactome": "R-DME-1433508", "name": "PKC alpha interacts with and phosphorylates KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434436", "species_113592", "species_10442600" ], "products": [ "species_29370", "species_10459176" ], "modifiers": [ [ "species_10434436", "catalyst" ] ], "additional_components": [ "FBgn0003091", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "P05130", "FBgn0003091", "FBgn0003091" ] }, "reaction_10442632": { "compartment": "compartment_876", "id": "reaction_10442632", "reactome": "R-DME-205244", "name": "Recruitment of CBL to KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442628", "species_10439032" ], "products": [ "species_10442630" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "FBgn0020224", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10458441": { "compartment": "compartment_70101", "id": "reaction_10458441", "reactome": "R-DME-1250383", "name": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10458438", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9V3C8", "FBgn0015296" ] }, "reaction_10458591": { "compartment": "compartment_7660", "id": "reaction_10458591", "reactome": "R-DME-1254386", "name": "ERBB4s80 forms a complex with estrogen receptor ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458515", "species_10458587" ], "products": [ "species_10458589" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "species_374146", "Q8WS79", "FBgn0035849", "species_374146", "Q8WS79", "FBgn0035849", "P04412", "FBgn0003731" ] }, "reaction_10458540": { "compartment": "compartment_70101", "id": "reaction_10458540", "reactome": "R-DME-1253343", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466", "species_10458536" ], "products": [ "species_10458538" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "FBgn0031972", "Q9VLU5", "FBgn0031972", "P04412", "FBgn0003731" ] }, "reaction_10458571": { "compartment": "compartment_70101", "id": "reaction_10458571", "reactome": "R-DME-1254291", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466", "species_10458559" ], "products": [ "species_10458561" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "Q24151", "Stat92E", "Q24151", "Stat92E", "P04412", "FBgn0003731" ] }, "reaction_10458554": { "compartment": "compartment_70101", "id": "reaction_10458554", "reactome": "R-DME-1254251", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544", "species_10458466" ], "products": [ "species_10458546" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q45VV3", "yki" ] }, "reaction_10458505": { "compartment": "compartment_70101", "id": "reaction_10458505", "reactome": "R-DME-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458456" ], "products": [ "species_10458466" ], "modifiers": [ [ "species_10458502", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9VQG2", "FBgn0031458", "Q86BE9", "FBgn0053198", "O02194", "FBgn0284421", "Q9VC27", "FBgn0039234" ] }, "reaction_10458569": { "compartment": "compartment_70101", "id": "reaction_10458569", "reactome": "R-DME-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458561" ], "products": [ "species_10458567" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "P04412", "FBgn0003731", "Q24151", "Stat92E", "P04412", "FBgn0003731" ] }, "reaction_10458552": { "compartment": "compartment_70101", "id": "reaction_10458552", "reactome": "R-DME-1254248", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458546" ], "products": [ "species_10458550" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "Q45VV3", "yki", "Q45VV3", "yki", "P04412", "FBgn0003731" ] }, "reaction_10458519": { "compartment": "compartment_70101", "id": "reaction_10458519", "reactome": "R-DME-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466" ], "products": [ "species_10458515" ], "modifiers": [ [ "species_10458517", "inhibitor" ] ], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731", "P00528", "FBgn0262733", "P04412", "FBgn0003731" ] }, "reaction_10458583": { "compartment": "compartment_70101", "id": "reaction_10458583", "reactome": "R-DME-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466" ], "products": [ "species_10458581" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731" ] }, "reaction_10462454": { "compartment": "compartment_70101", "id": "reaction_10462454", "reactome": "R-DME-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10462447" ], "products": [ "species_10462451" ], "modifiers": [ [ "species_10462447", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174" ] }, "reaction_10458531": { "compartment": "compartment_876", "id": "reaction_10458531", "reactome": "R-DME-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456500", "species_10458522" ], "products": [ "species_10458524" ], "modifiers": [], "additional_components": [ "FBgn0003557", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10458529": { "compartment": "compartment_70101", "id": "reaction_10458529", "reactome": "R-DME-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10458524" ], "products": [ "species_10458526" ], "modifiers": [ [ "species_10458524", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10462449": { "compartment": "compartment_70101", "id": "reaction_10462449", "reactome": "R-DME-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456484", "species_10458460" ], "products": [ "species_10462447" ], "modifiers": [], "additional_components": [ "FBgn0259174", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174" ] }, "reaction_10497518": { "compartment": "compartment_876", "id": "reaction_10497518", "reactome": "R-DME-9612219", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466", "species_10444503" ], "products": [ "species_10458517" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "FBgn0262733", "P00528", "FBgn0262733", "P04412", "FBgn0003731" ] }, "reaction_10476599": { "compartment": "compartment_70101", "id": "reaction_10476599", "reactome": "R-DME-5685366", "name": "GRB2-1:SOS1 binds p-Y-SHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475810", "species_10431797" ], "products": [ "species_10475816" ], "modifiers": [], "additional_components": [ "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9V3C8", "FBgn0015296" ] }, "reaction_10437918": { "compartment": "compartment_876", "id": "reaction_10437918", "reactome": "R-DME-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10437914" ], "products": [ "species_10437916" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "FBgn0026376", "M9PCE9", "FBgn0026376", "species_29438", "P08646", "RAS85D" ] }, "reaction_10497488": { "compartment": "compartment_70101", "id": "reaction_10497488", "reactome": "R-DME-9610166", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458636" ], "products": [ "species_10440935" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10497474": { "compartment": "compartment_74700", "id": "reaction_10497474", "reactome": "R-DME-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10497463" ], "products": [ "species_10497467", "species_29370" ], "modifiers": [ [ "species_10497463", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1" ] }, "reaction_10497478": { "compartment": "compartment_70101", "id": "reaction_10497478", "reactome": "R-DME-9610154", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497476" ], "products": [ "species_10475873", "species_10497461", "species_10433771" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "FBgn0003256" ] }, "reaction_10497465": { "compartment": "compartment_74700", "id": "reaction_10497465", "reactome": "R-DME-9610152", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475906", "species_10497461", "species_10433742" ], "products": [ "species_10497463" ], "modifiers": [], "additional_components": [ "Q24324", "phospho-Dsor1", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "FBgn0003256", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1" ] }, "reaction_10497481": { "compartment": "compartment_70101", "id": "reaction_10497481", "reactome": "R-DME-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497467", "species_113592" ], "products": [ "species_29370", "species_10497476" ], "modifiers": [ [ "species_10497467", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1" ] }, "reaction_10475989": { "compartment": "compartment_70101", "id": "reaction_10475989", "reactome": "R-DME-5674385", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433771" ], "products": [ "species_10458636" ], "modifiers": [], "additional_components": [ "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10497486": { "compartment": "compartment_74700", "id": "reaction_10497486", "reactome": "R-DME-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497483", "species_113592" ], "products": [ "species_29370", "species_10497461" ], "modifiers": [ [ "species_10497483", "catalyst" ] ], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta" ] }, "reaction_10438835": { "compartment": "compartment_984", "id": "reaction_10438835", "reactome": "R-DME-177479", "name": "Axonal transport of NGF:Trk complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438827" ], "products": [ "species_10438827" ], "modifiers": [ [ "species_10438832", "catalyst" ] ], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "FBgn0033687" ] }, "reaction_10440762": { "compartment": "compartment_947587", "id": "reaction_10440762", "reactome": "R-DME-198266", "name": "PI3K produces PIP3 and other phosphatidyl inositides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10440759", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9XTN2", "chico" ] }, "reaction_10441962": { "compartment": "compartment_876", "id": "reaction_10441962", "reactome": "R-DME-202692", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10434902" ], "products": [ "species_10441960" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_179838" ] }, "reaction_10431807": { "compartment": "compartment_70101", "id": "reaction_10431807", "reactome": "R-DME-74736", "name": "GRB2-1:SOS1 binds p-IRS1,p-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10431801" ], "products": [ "species_10431805" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10433706": { "compartment": "compartment_876", "id": "reaction_10433706", "reactome": "R-DME-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10433702" ], "products": [ "species_10433704" ], "modifiers": [], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10433715": { "compartment": "compartment_70101", "id": "reaction_10433715", "reactome": "R-DME-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433696", "species_113592" ], "products": [ "species_10433712", "species_29370" ], "modifiers": [ [ "species_10433704", "catalyst" ] ], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "Q8INB9", "phospho-Akt1", "species_179838", "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10433698": { "compartment": "compartment_876", "id": "reaction_10433698", "reactome": "R-DME-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10433694" ], "products": [ "species_10433696", "species_10433688" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "Q9V3Z1", "FBgn0028978", "Q8INB9", "phospho-Akt1", "species_179838", "FBgn0028978" ] }, "reaction_10433683": { "compartment": "compartment_70101", "id": "reaction_10433683", "reactome": "R-DME-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10433680", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9XTN2", "chico", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10431824": { "compartment": "compartment_70101", "id": "reaction_10431824", "reactome": "R-DME-74737", "name": "p-Y-IRS1,p-Y-IRS2 bind PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431801", "species_10431820" ], "products": [ "species_10431822" ], "modifiers": [], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9XTN2", "chico" ] }, "reaction_10431786": { "compartment": "compartment_876", "id": "reaction_10431786", "reactome": "R-DME-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431784" ], "products": [ "species_10431589" ], "modifiers": [], "additional_components": [ "P09208", "InR", "P09208", "InR" ] }, "reaction_10431768": { "compartment": "compartment_17940", "id": "reaction_10431768", "reactome": "R-DME-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10431765", "catalyst" ] ], "additional_components": [ "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q7JR49", "FBgn0262515" ] }, "reaction_10471490": { "compartment": "compartment_171062", "id": "reaction_10471490", "reactome": "R-DME-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431763", "species_10431758" ], "products": [ "species_10431765" ], "modifiers": [], "additional_components": [ "FBgn0262515", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q7JR49", "FBgn0262515" ] }, "reaction_10433749": { "compartment": "compartment_70101", "id": "reaction_10433749", "reactome": "R-DME-109823", "name": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10431805" ], "products": [ "species_10433747", "species_29370" ], "modifiers": [ [ "species_10433740", "catalyst" ] ], "additional_components": [ "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0003256" ] }, "reaction_10476611": { "compartment": "compartment_70101", "id": "reaction_10476611", "reactome": "R-DME-5686315", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433747" ], "products": [ "species_10433733", "species_10431801" ], "modifiers": [], "additional_components": [ "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10433745": { "compartment": "compartment_70101", "id": "reaction_10433745", "reactome": "R-DME-109822", "name": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10431832" ], "products": [ "species_29370", "species_10433735" ], "modifiers": [ [ "species_10433740", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0003256" ] }, "reaction_10476609": { "compartment": "compartment_70101", "id": "reaction_10476609", "reactome": "R-DME-5686074", "name": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433735" ], "products": [ "species_10433733", "species_10431830" ], "modifiers": [], "additional_components": [ "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296" ] }, "reaction_10433725": { "compartment": "compartment_70101", "id": "reaction_10433725", "reactome": "R-DME-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431795", "species_10431791" ], "products": [ "species_10431797" ], "modifiers": [], "additional_components": [ "FBgn0004638", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10431834": { "compartment": "compartment_70101", "id": "reaction_10431834", "reactome": "R-DME-74746", "name": "GRB2-1:SOS1 binds p-Y427-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10431830" ], "products": [ "species_10431832" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10446431": { "compartment": "compartment_70101", "id": "reaction_10446431", "reactome": "R-DME-389083", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10446424" ], "products": [ "species_29370", "species_10446426" ], "modifiers": [ [ "species_10446424", "catalyst" ], [ "species_10446429", "inhibitor" ] ], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964" ] }, "reaction_10489777": { "compartment": "compartment_984", "id": "reaction_10489777", "reactome": "R-DME-8865276", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446192" ], "products": [ "species_10489771", "species_10439284", "species_10439338" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "FBgn0030964", "Q9VWP6", "FBgn0030964", "FBgn0030964", "FBgn0004509" ] }, "reaction_10446204": { "compartment": "compartment_20699", "id": "reaction_10446204", "reactome": "R-DME-382053", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446186" ], "products": [ "species_10446202" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964" ] }, "reaction_10439340": { "compartment": "compartment_984", "id": "reaction_10439340", "reactome": "R-DME-186785", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439336" ], "products": [ "species_10439338", "species_10439276" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "FBgn0030964", "Q9VWP6", "FBgn0030964", "FBgn0004509" ] }, "reaction_10439324": { "compartment": "compartment_876", "id": "reaction_10439324", "reactome": "R-DME-186773", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439286", "species_10439308" ], "products": [ "species_10439318" ], "modifiers": [ [ "species_10439320", "inhibitor" ], [ "species_10439322", "inhibitor" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10498453": { "compartment": "compartment_876", "id": "reaction_10498453", "reactome": "R-DME-9674093", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9674075", "species_10446424" ], "products": [ "species_10446429" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964" ] }, "reaction_10446441": { "compartment": "compartment_70101", "id": "reaction_10446441", "reactome": "R-DME-389086", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446436", "species_113592" ], "products": [ "species_29370", "species_10446438" ], "modifiers": [ [ "species_10446436", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10498455": { "compartment": "compartment_876", "id": "reaction_10498455", "reactome": "R-DME-9674095", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9674079", "species_10439308" ], "products": [ "species_10439320" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10439359": { "compartment": "compartment_70101", "id": "reaction_10439359", "reactome": "R-DME-186800", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10439328", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10439294": { "compartment": "compartment_876", "id": "reaction_10439294", "reactome": "R-DME-186765", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439288", "species_10439290" ], "products": [ "species_10439292" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "FBgn0003416", "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10439356": { "compartment": "compartment_70101", "id": "reaction_10439356", "reactome": "R-DME-186798", "name": "GAP binds to PDGF-beta receptors only", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439344", "species_10439352" ], "products": [ "species_10439354" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "FBgn0003969", "Q8IR23", "FBgn0003969", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10445851": { "compartment": "compartment_70101", "id": "reaction_10445851", "reactome": "R-DME-380780", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439361", "species_113592" ], "products": [ "species_29370", "species_10445848" ], "modifiers": [ [ "species_10439361", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P00528", "FBgn0262733" ] }, "reaction_10446232": { "compartment": "compartment_70101", "id": "reaction_10446232", "reactome": "R-DME-382058", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444486", "species_10439288" ], "products": [ "species_10446230" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10446164": { "compartment": "compartment_70101", "id": "reaction_10446164", "reactome": "R-DME-382052", "name": "p130Cas and C3G bind PDGFR bound Crk", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446160", "species_10446150", "species_10446155" ], "products": [ "species_10446162" ], "modifiers": [], "additional_components": [ "FBgn0259228", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9XYM0", "FBgn0024811", "FBgn0035101", "A4IJ58", "FBgn0035101", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9XYM0", "FBgn0024811", "O77086", "FBgn0259228" ] }, "reaction_10459917": { "compartment": "compartment_876", "id": "reaction_10459917", "reactome": "R-DME-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439292" ], "products": [ "species_29370", "species_10459912" ], "modifiers": [ [ "species_10439292", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10445867": { "compartment": "compartment_70101", "id": "reaction_10445867", "reactome": "R-DME-380782", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439288", "species_10445855" ], "products": [ "species_10445865" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q24151", "Stat92E", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10459914": { "compartment": "compartment_876", "id": "reaction_10459914", "reactome": "R-DME-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459912" ], "products": [ "species_10439288", "species_10441915" ], "modifiers": [], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "FBgn0003416" ] }, "reaction_10439370": { "compartment": "compartment_70101", "id": "reaction_10439370", "reactome": "R-DME-186834", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10439365", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10439367": { "compartment": "compartment_70101", "id": "reaction_10439367", "reactome": "R-DME-186826", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10439288" ], "products": [ "species_10439365" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10446214": { "compartment": "compartment_70101", "id": "reaction_10446214", "reactome": "R-DME-382056", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446146", "species_10439288" ], "products": [ "species_10446150" ], "modifiers": [], "additional_components": [ "FBgn0024811", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9XYM0", "FBgn0024811" ] }, "reaction_10439363": { "compartment": "compartment_876", "id": "reaction_10439363", "reactome": "R-DME-186819", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438881", "species_10439288" ], "products": [ "species_10439361" ], "modifiers": [], "additional_components": [ "FBgn0262733", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P00528", "FBgn0262733" ] }, "reaction_10439330": { "compartment": "compartment_70101", "id": "reaction_10439330", "reactome": "R-DME-186780", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439288", "species_10431820" ], "products": [ "species_10439328" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10446228": { "compartment": "compartment_984", "id": "reaction_10446228", "reactome": "R-DME-382057", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446216" ], "products": [ "species_10446226" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964" ] }, "reaction_10439347": { "compartment": "compartment_70101", "id": "reaction_10439347", "reactome": "R-DME-186786", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439342" ], "products": [ "species_10439344", "species_29370" ], "modifiers": [ [ "species_10439342", "catalyst" ] ], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964" ] }, "reaction_10489775": { "compartment": "compartment_984", "id": "reaction_10489775", "reactome": "R-DME-8865275", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446190" ], "products": [ "species_10439282", "species_10489771" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964", "FBgn0030964", "FBgn0004509" ] }, "reaction_10479727": { "compartment": "compartment_70101", "id": "reaction_10479727", "reactome": "R-DME-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479721", "species_10475516" ], "products": [ "species_10479725" ], "modifiers": [], "additional_components": [ "Q9VG04", "FBgn0038110", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "Q9VG04", "FBgn0038110", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10479723": { "compartment": "compartment_70101", "id": "reaction_10479723", "reactome": "R-DME-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458352", "species_10479719" ], "products": [ "species_10479721" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0038110", "Q9VG04", "FBgn0038110", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10498279": { "compartment": "compartment_70101", "id": "reaction_10498279", "reactome": "R-DME-9652264", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9652360", "species_10462124" ], "products": [ "species_10462235" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573" ] }, "reaction_10462237": { "compartment": "compartment_876", "id": "reaction_10462237", "reactome": "R-DME-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462226", "species_113592" ], "products": [ "species_29370", "species_10458345" ], "modifiers": [ [ "species_10462226", "catalyst" ], [ "species_10462231", "inhibitor" ], [ "species_10462235", "inhibitor" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573" ] }, "reaction_10458911": { "compartment": "compartment_876", "id": "reaction_10458911", "reactome": "R-DME-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10458908", "catalyst" ] ], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10458913": { "compartment": "compartment_876", "id": "reaction_10458913", "reactome": "R-DME-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458352", "species_10438839" ], "products": [ "species_10458904" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10458920": { "compartment": "compartment_876", "id": "reaction_10458920", "reactome": "R-DME-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10458917", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10462245": { "compartment": "compartment_876", "id": "reaction_10462245", "reactome": "R-DME-1963586", "name": "SRC family kinases phosphorylate ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462226", "species_113592" ], "products": [ "species_29370", "species_10462221" ], "modifiers": [ [ "species_10444503", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0262733" ] }, "reaction_10458359": { "compartment": "compartment_876", "id": "reaction_10458359", "reactome": "R-DME-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458354", "species_113592" ], "products": [ "species_10458356", "species_29370" ], "modifiers": [ [ "species_10458354", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10491995": { "compartment": "compartment_70101", "id": "reaction_10491995", "reactome": "R-DME-8934446", "name": "Activated PKC phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10476601" ], "products": [ "species_10491981", "species_29370" ], "modifiers": [ [ "species_10491992", "catalyst" ] ], "additional_components": [ "FBgn0015296", "FBgn0015296", "species_74016", "P05130", "FBgn0003091", "species_114519", "species_33625" ] }, "reaction_10489700": { "compartment": "compartment_876", "id": "reaction_10489700", "reactome": "R-DME-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10489685" ], "products": [ "species_29372", "species_10489697" ], "modifiers": [ [ "species_10489685", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10462217": { "compartment": "compartment_876", "id": "reaction_10462217", "reactome": "R-DME-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458352", "species_10462213" ], "products": [ "species_10462215" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0262081", "Q8INJ8", "FBgn0262081", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10462134": { "compartment": "compartment_70101", "id": "reaction_10462134", "reactome": "R-DME-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10462124" ], "products": [ "species_10462131" ], "modifiers": [ [ "species_10456634", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "FBgn0039632" ] }, "reaction_10458958": { "compartment": "compartment_70101", "id": "reaction_10458958", "reactome": "R-DME-1358792", "name": "RNF41 ubiquitinates activated ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458953", "species_10426987" ], "products": [ "species_10458955", "species_10456701" ], "modifiers": [ [ "species_10458953", "catalyst" ] ], "additional_components": [ "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649", "Q9VUV7", "FBgn0283649" ] }, "reaction_10458939": { "compartment": "compartment_70101", "id": "reaction_10458939", "reactome": "R-DME-1358790", "name": "RNF41 ubiquitinates ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458934", "species_10426987" ], "products": [ "species_10458936", "species_10456701" ], "modifiers": [ [ "species_10458934", "catalyst" ] ], "additional_components": [ "Q9VUV7", "FBgn0283649", "P04412", "FBgn0003731", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "FBgn0283649", "Q9VUV7", "FBgn0283649", "P04412", "FBgn0003731" ] }, "reaction_10458967": { "compartment": "compartment_70101", "id": "reaction_10458967", "reactome": "R-DME-1358801", "name": "ERBB3 binds RNF41 ubiquitin ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458281", "species_10456701" ], "products": [ "species_10458934" ], "modifiers": [], "additional_components": [ "FBgn0003731", "FBgn0283649", "Q9VUV7", "FBgn0283649", "P04412", "FBgn0003731" ] }, "reaction_10458949": { "compartment": "compartment_70101", "id": "reaction_10458949", "reactome": "R-DME-1358791", "name": "Phosphorylation of USP8 by P-AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458944", "species_113592" ], "products": [ "species_10458947", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0038862", "FBgn0038862" ] }, "reaction_10458965": { "compartment": "compartment_70101", "id": "reaction_10458965", "reactome": "R-DME-1358797", "name": "Ubiquitinated RNF41 binds P-USP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458929", "species_10458947" ], "products": [ "species_10458960" ], "modifiers": [], "additional_components": [ "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0038862", "Q9VDD8", "FBgn0038862", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10458932": { "compartment": "compartment_70101", "id": "reaction_10458932", "reactome": "R-DME-1358789", "name": "Self-ubiquitination of RNF41", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10456701" ], "products": [ "species_10458929" ], "modifiers": [ [ "species_10456701", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649" ] }, "reaction_10458963": { "compartment": "compartment_70101", "id": "reaction_10458963", "reactome": "R-DME-1358795", "name": "Deubiquitination of RNF41 by P-USP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458960" ], "products": [ "species_10458947", "species_10426987", "species_10456701" ], "modifiers": [ [ "species_10458960", "catalyst" ] ], "additional_components": [ "Q9VDD8", "FBgn0038862", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0038862", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649", "Q9VDD8", "FBgn0038862", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10462129": { "compartment": "compartment_70101", "id": "reaction_10462129", "reactome": "R-DME-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10462124" ], "products": [ "species_10462126" ], "modifiers": [ [ "species_10456460", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "FBgn0027052" ] }, "reaction_10462224": { "compartment": "compartment_876", "id": "reaction_10462224", "reactome": "R-DME-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10462221" ], "products": [ "species_29370", "species_10458350" ], "modifiers": [ [ "species_10462221", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10498464": { "compartment": "compartment_459", "id": "reaction_10498464", "reactome": "R-DME-9674531", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498460", "species_10438846" ], "products": [ "species_10498462" ], "modifiers": [], "additional_components": [ "FBgn0036460", "FBgn0003731", "P04412", "FBgn0003731", "M9NE98", "FBgn0036460" ] }, "reaction_10438959": { "compartment": "compartment_70101", "id": "reaction_10438959", "reactome": "R-DME-177934", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10438855" ], "products": [ "species_29370", "species_10438908" ], "modifiers": [ [ "species_10438855", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10439003": { "compartment": "compartment_984", "id": "reaction_10439003", "reactome": "R-DME-177942", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438851", "species_10438846" ], "products": [ "species_10438853" ], "modifiers": [ [ "species_10439001", "inhibitor" ] ], "additional_components": [ "FBgn0000119", "FBgn0003731", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0034083" ] }, "reaction_10438857": { "compartment": "compartment_876", "id": "reaction_10438857", "reactome": "R-DME-177922", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438853" ], "products": [ "species_10438855" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10443325": { "compartment": "compartment_876", "id": "reaction_10443325", "reactome": "R-DME-212713", "name": "Active PLC-gamma1 dissociates from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443320" ], "products": [ "species_10441915", "species_10438908" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VXH3", "FBgn0003416", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10443323": { "compartment": "compartment_70101", "id": "reaction_10443323", "reactome": "R-DME-212710", "name": "EGFR activates PLC-gamma1 by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443316", "species_113592" ], "products": [ "species_29370", "species_10443320" ], "modifiers": [ [ "species_10443316", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VXH3", "FBgn0003416", "Q9VXH3", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10443318": { "compartment": "compartment_876", "id": "reaction_10443318", "reactome": "R-DME-212706", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438908", "species_10441886" ], "products": [ "species_10443316" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0003416", "Q9VXH3", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10438943": { "compartment": "compartment_70101", "id": "reaction_10438943", "reactome": "R-DME-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10438937" ], "products": [ "species_29370", "species_10438910" ], "modifiers": [ [ "species_10438937", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438927": { "compartment": "compartment_70101", "id": "reaction_10438927", "reactome": "R-DME-177924", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438912", "species_29356" ], "products": [ "species_29372", "species_10438925" ], "modifiers": [ [ "species_10438912", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438841": { "compartment": "compartment_70101", "id": "reaction_10438841", "reactome": "R-DME-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433424", "species_10431791" ], "products": [ "species_10438839" ], "modifiers": [], "additional_components": [ "FBgn0016794", "FBgn0004638", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794" ] }, "reaction_10438969": { "compartment": "compartment_70101", "id": "reaction_10438969", "reactome": "R-DME-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438912", "species_29356" ], "products": [ "species_29372", "species_10438967" ], "modifiers": [ [ "species_10438912", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438996": { "compartment": "compartment_70101", "id": "reaction_10438996", "reactome": "R-DME-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438935", "species_10438908" ], "products": [ "species_10438937" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10439027": { "compartment": "compartment_70101", "id": "reaction_10439027", "reactome": "R-DME-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10438839" ], "products": [ "species_10438933" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438915": { "compartment": "compartment_70101", "id": "reaction_10438915", "reactome": "R-DME-177923", "name": "Sustained activation of SRC kinase by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10438877" ], "products": [ "species_29372", "species_10438883", "species_10438862" ], "modifiers": [ [ "species_10438912", "catalyst" ] ], "additional_components": [ "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q2PDT4", "FBgn0041789", "Q2PDT4", "FBgn0041789", "P00528", "FBgn0262733", "FBgn0262081", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438994": { "compartment": "compartment_70101", "id": "reaction_10438994", "reactome": "R-DME-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10438991", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10439199": { "compartment": "compartment_70101", "id": "reaction_10439199", "reactome": "R-DME-183089", "name": "CBL binds and ubiquitinates phosphorylated Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439111", "species_10426987", "species_10439039" ], "products": [ "species_10439174" ], "modifiers": [ [ "species_10439039", "catalyst" ] ], "additional_components": [ "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10439103": { "compartment": "compartment_70101", "id": "reaction_10439103", "reactome": "R-DME-182986", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439090", "species_10426987" ], "products": [ "species_10439100" ], "modifiers": [ [ "species_10439090", "catalyst" ] ], "additional_components": [ "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q8T390", "FBgn0038659", "Q9VS85", "FBgn0028582", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659" ] }, "reaction_10439197": { "compartment": "compartment_70101", "id": "reaction_10439197", "reactome": "R-DME-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439192", "species_10426987" ], "products": [ "species_10439185", "species_10439194" ], "modifiers": [ [ "species_10439192", "catalyst" ] ], "additional_components": [ "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10439164": { "compartment": "compartment_70101", "id": "reaction_10439164", "reactome": "R-DME-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10439132" ], "products": [ "species_10439156" ], "modifiers": [ [ "species_10439132", "catalyst" ], [ "species_10439162", "inhibitor" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "FBgn0267486" ] }, "reaction_10439130": { "compartment": "compartment_70101", "id": "reaction_10439130", "reactome": "R-DME-182993", "name": "Ubiquitination of stimulated EGFR (CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10439039" ], "products": [ "species_10439127" ], "modifiers": [ [ "species_10439039", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10439190": { "compartment": "compartment_70101", "id": "reaction_10439190", "reactome": "R-DME-183067", "name": "Localization of CBL:GRB2 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439179", "species_10438908" ], "products": [ "species_10439185" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439125": { "compartment": "compartment_876", "id": "reaction_10439125", "reactome": "R-DME-182990", "name": "Sprouty sequesters CBL away from active EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439090", "species_10439119" ], "products": [ "species_10439123" ], "modifiers": [], "additional_components": [ "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659", "FBgn0014388", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659" ] }, "reaction_10439188": { "compartment": "compartment_70101", "id": "reaction_10439188", "reactome": "R-DME-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439185", "species_113592" ], "products": [ "species_29370", "species_10439132" ], "modifiers": [ [ "species_10439185", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439152": { "compartment": "compartment_70101", "id": "reaction_10439152", "reactome": "R-DME-183002", "name": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439146", "species_10439148" ], "products": [ "species_10439150" ], "modifiers": [], "additional_components": [ "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10439183": { "compartment": "compartment_876", "id": "reaction_10439183", "reactome": "R-DME-183055", "name": "Binding of CBL to EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10438908" ], "products": [ "species_10439034" ], "modifiers": [], "additional_components": [ "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224" ] }, "reaction_10490064": { "compartment": "compartment_876", "id": "reaction_10490064", "reactome": "R-DME-8867041", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490059", "species_113592" ], "products": [ "species_10490061", "species_29370" ], "modifiers": [ [ "species_10490059", "catalyst" ] ], "additional_components": [ "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582" ] }, "reaction_10439181": { "compartment": "compartment_70101", "id": "reaction_10439181", "reactome": "R-DME-183052", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10431791" ], "products": [ "species_10439179" ], "modifiers": [], "additional_components": [ "FBgn0020224", "FBgn0004638", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439117": { "compartment": "compartment_876", "id": "reaction_10439117", "reactome": "R-DME-182988", "name": "Sprouty lures CBL away from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439109", "species_10439032" ], "products": [ "species_10439115" ], "modifiers": [], "additional_components": [ "FBgn0014388", "FBgn0020224", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388" ] }, "reaction_10490066": { "compartment": "compartment_876", "id": "reaction_10490066", "reactome": "R-DME-8867044", "name": "EGFR binds EPS15, EPN1, EPS15L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439047", "species_10439066", "species_10439068", "species_10439148", "species_179856" ], "products": [ "species_10490059" ], "modifiers": [], "additional_components": [ "FBgn0028582", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582" ] }, "reaction_10439177": { "compartment": "compartment_70101", "id": "reaction_10439177", "reactome": "R-DME-183051", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439170", "species_10426987" ], "products": [ "species_10439174" ], "modifiers": [ [ "species_10439170", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O44783", "FBgn0014388", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388" ] }, "reaction_10490074": { "compartment": "compartment_876", "id": "reaction_10490074", "reactome": "R-DME-8867047", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490061", "species_29356" ], "products": [ "species_29372", "species_10490059" ], "modifiers": [ [ "species_10490071", "catalyst" ] ], "additional_components": [ "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "FBgn0261985" ] }, "reaction_10439203": { "compartment": "compartment_70101", "id": "reaction_10439203", "reactome": "R-DME-183094", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10439146" ], "products": [ "species_10439201" ], "modifiers": [], "additional_components": [ "FBgn0020224", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439042": { "compartment": "compartment_70101", "id": "reaction_10439042", "reactome": "R-DME-182969", "name": "Phosphorylation of CBL (EGFR:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439034" ], "products": [ "species_29370", "species_10439039" ], "modifiers": [ [ "species_10439034", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224" ] }, "reaction_10438973": { "compartment": "compartment_70101", "id": "reaction_10438973", "reactome": "R-DME-177936", "name": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10438953" ], "products": [ "species_10438971" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10438956": { "compartment": "compartment_70101", "id": "reaction_10438956", "reactome": "R-DME-177933", "name": "SHC1 phosphorylation by phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438929", "species_113592" ], "products": [ "species_29370", "species_10438953" ], "modifiers": [ [ "species_10438929", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296" ] }, "reaction_10438931": { "compartment": "compartment_70101", "id": "reaction_10438931", "reactome": "R-DME-177925", "name": "SHC1 binds to the phosphorylated EGF receptor:ligand complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431840", "species_10438908" ], "products": [ "species_10438929" ], "modifiers": [], "additional_components": [ "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296" ] }, "reaction_10439009": { "compartment": "compartment_70101", "id": "reaction_10439009", "reactome": "R-DME-177945", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10438971", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10438978": { "compartment": "compartment_70101", "id": "reaction_10438978", "reactome": "R-DME-177937", "name": "Phosphorylation of EGFR by SRC kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10438855" ], "products": [ "species_29370", "species_10438908" ], "modifiers": [ [ "species_10438975", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0262733" ] }, "reaction_10439006": { "compartment": "compartment_70101", "id": "reaction_10439006", "reactome": "R-DME-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10438908" ], "products": [ "species_10438982" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10438985": { "compartment": "compartment_70101", "id": "reaction_10438985", "reactome": "R-DME-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10438982", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10486291": { "compartment": "compartment_7660", "id": "reaction_10486291", "reactome": "R-DME-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10486280" ], "products": [ "species_10427430", "species_10486289" ], "modifiers": [ [ "species_10467616", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0030366" ] }, "reaction_10486293": { "compartment": "compartment_7660", "id": "reaction_10486293", "reactome": "R-DME-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486289" ], "products": [ "species_10441147" ], "modifiers": [], "additional_components": [] }, "reaction_10486282": { "compartment": "compartment_70101", "id": "reaction_10486282", "reactome": "R-DME-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486276" ], "products": [ "species_10486280" ], "modifiers": [], "additional_components": [] }, "reaction_10486287": { "compartment": "compartment_70101", "id": "reaction_10486287", "reactome": "R-DME-6807106", "name": "PTEN undergoes monoubiquitination", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10441147" ], "products": [ "species_10486276" ], "modifiers": [ [ "species_10486284", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10433277": { "compartment": "compartment_7660", "id": "reaction_10433277", "reactome": "R-DME-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433273", "species_10429982" ], "products": [ "species_10433275" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10433287": { "compartment": "compartment_7660", "id": "reaction_10433287", "reactome": "R-DME-77592", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433283" ], "products": [ "species_10430001", "species_10430036", "species_10433285", "species_10430024", "species_112165" ], "modifiers": [], "additional_components": [ "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7KNF2", "FBgn0005648", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q7K4N3", "FBgn0022942", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q9V3L6", "FBgn0022943", "Q7KNF2", "FBgn0005648", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872" ] }, "reaction_10433281": { "compartment": "compartment_7660", "id": "reaction_10433281", "reactome": "R-DME-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430001", "species_10433275" ], "products": [ "species_10433279" ], "modifiers": [], "additional_components": [ "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867" ] }, "reaction_10461644": { "compartment": "compartment_17957", "id": "reaction_10461644", "reactome": "R-DME-1855200", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024002" ], "products": [ "species_113551", "species_2024016" ], "modifiers": [ [ "species_10461541", "catalyst" ] ], "additional_components": [ "FBgn0026061" ] }, "reaction_10461544": { "compartment": "compartment_17957", "id": "reaction_10461544", "reactome": "R-DME-1855163", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024008" ], "products": [ "species_113551", "species_2024012" ], "modifiers": [ [ "species_10461541", "catalyst" ] ], "additional_components": [ "FBgn0026061" ] }, "reaction_10461732": { "compartment": "compartment_17957", "id": "reaction_10461732", "reactome": "R-DME-1855225", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024018" ], "products": [ "species_113551", "species_2564836" ], "modifiers": [ [ "species_10461541", "catalyst" ] ], "additional_components": [ "FBgn0026061" ] }, "reaction_10473766": { "compartment": "compartment_876", "id": "reaction_10473766", "reactome": "R-DME-5623632", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473760", "species_10433704" ], "products": [ "species_10473764" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621", "Q9W0V1", "Pdk1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621" ] }, "reaction_10475670": { "compartment": "compartment_70101", "id": "reaction_10475670", "reactome": "R-DME-5671749", "name": "p-T774-PKN1 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475665", "species_113592" ], "products": [ "species_10431988", "species_29370", "species_10473769" ], "modifiers": [ [ "species_10475665", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "A1Z7T0", "FBgn0020621", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0020621", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "A1Z7T0", "FBgn0020621" ] }, "reaction_10432022": { "compartment": "compartment_70101", "id": "reaction_10432022", "reactome": "R-DME-75016", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432018", "species_10431988" ], "products": [ "species_10432020" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon" ] }, "reaction_10475685": { "compartment": "compartment_70101", "id": "reaction_10475685", "reactome": "R-DME-5671772", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475630", "species_10475678" ], "products": [ "species_10475683" ], "modifiers": [], "additional_components": [ "M9NEB2", "FBgn0005536", "P48462", "flw", "FBgn0032297", "Q9VKQ5", "FBgn0032297", "M9NEB2", "FBgn0005536", "P48462", "flw" ] }, "reaction_10475667": { "compartment": "compartment_70101", "id": "reaction_10475667", "reactome": "R-DME-5671737", "name": "p-T774-PKN1 binds CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473769", "species_10435503" ], "products": [ "species_10475665" ], "modifiers": [], "additional_components": [ "FBgn0020621", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "A1Z7T0", "FBgn0020621" ] }, "reaction_10473762": { "compartment": "compartment_876", "id": "reaction_10473762", "reactome": "R-DME-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473750", "species_10473758" ], "products": [ "species_10473760" ], "modifiers": [], "additional_components": [ "FBgn0020621", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621" ] }, "reaction_10473778": { "compartment": "compartment_70101", "id": "reaction_10473778", "reactome": "R-DME-5623667", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473764", "species_113592" ], "products": [ "species_29370", "species_10433704", "species_10473769", "species_10473758" ], "modifiers": [ [ "species_10473764", "catalyst" ] ], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621", "Q9W0V1", "Pdk1", "species_179838", "FBgn0020621", "P48148", "Rho1", "species_29438", "Q9W0V1", "Pdk1", "species_179838", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621" ] }, "reaction_10474173": { "compartment": "compartment_7660", "id": "reaction_10474173", "reactome": "R-DME-5625717", "name": "Phosphorylated PKN1 binds androgen receptor (AR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473330", "species_10473769" ], "products": [ "species_10474171" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849", "FBgn0020621", "A1Z7T0", "FBgn0020621", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849" ] }, "reaction_10474183": { "compartment": "compartment_7660", "id": "reaction_10474183", "reactome": "R-DME-5625745", "name": "PKN1 stimulates association of AR with NCOA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474177", "species_10440442" ], "products": [ "species_10474181" ], "modifiers": [], "additional_components": [ "A1Z7T0", "FBgn0020621", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "FBgn0041092", "A1Z7T0", "FBgn0020621", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "M9ND53", "FBgn0041092" ] }, "reaction_10474179": { "compartment": "compartment_70101", "id": "reaction_10474179", "reactome": "R-DME-5625738", "name": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474171" ], "products": [ "species_10474177" ], "modifiers": [], "additional_components": [ "A1Z7T0", "FBgn0020621", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849", "A1Z7T0", "FBgn0020621", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079" ] }, "reaction_10475681": { "compartment": "compartment_70101", "id": "reaction_10475681", "reactome": "R-DME-5671763", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475675" ], "products": [ "species_29370", "species_10475678" ], "modifiers": [ [ "species_10473769", "catalyst" ] ], "additional_components": [ "FBgn0032297", "FBgn0032297", "FBgn0020621" ] }, "reaction_10475533": { "compartment": "compartment_70101", "id": "reaction_10475533", "reactome": "R-DME-5665999", "name": "MKL1 translocates from cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475531" ], "products": [ "species_10469150" ], "modifiers": [], "additional_components": [ "FBgn0052296", "FBgn0052296" ] }, "reaction_10469116": { "compartment": "compartment_70101", "id": "reaction_10469116", "reactome": "R-DME-3858495", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469108", "species_10469112" ], "products": [ "species_10469114" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "M9MSM5", "FBgn0025641", "species_29926", "P48148", "Rho1", "species_29438", "species_29926", "P48148", "Rho1", "species_29438", "P51140", "phospho-dsh", "M9MSM5", "FBgn0025641" ] }, "reaction_10475529": { "compartment": "compartment_7660", "id": "reaction_10475529", "reactome": "R-DME-5665998", "name": "MKL1 binds SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475525", "species_10469150" ], "products": [ "species_10475527" ], "modifiers": [], "additional_components": [ "FBgn0004101", "FBgn0052296", "B7Z043", "FBgn0052296", "Q24535", "FBgn0004101" ] }, "reaction_10475542": { "compartment": "compartment_7660", "id": "reaction_10475542", "reactome": "R-DME-5666008", "name": "SCAI binds SRF:MKL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475538", "species_10475527" ], "products": [ "species_10475540" ], "modifiers": [], "additional_components": [ "FBgn0035677", "B7Z043", "FBgn0052296", "Q24535", "FBgn0004101", "B7Z043", "FBgn0052296", "Q24535", "FBgn0004101", "M9PER3", "FBgn0035677" ] }, "reaction_10475558": { "compartment": "compartment_70101", "id": "reaction_10475558", "reactome": "R-DME-5666104", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475552", "species_10440003" ], "products": [ "species_10475556" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "FBgn0262733", "P00528", "FBgn0262733", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202" ] }, "reaction_10469110": { "compartment": "compartment_70101", "id": "reaction_10469110", "reactome": "R-DME-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469106", "species_10441719" ], "products": [ "species_10469108" ], "modifiers": [], "additional_components": [ "FBgn0025641", "P51140", "phospho-dsh", "M9MSM5", "FBgn0025641" ] }, "reaction_10475554": { "compartment": "compartment_70101", "id": "reaction_10475554", "reactome": "R-DME-5666088", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475546", "species_10475550" ], "products": [ "species_10475552" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202" ] }, "reaction_10475457": { "compartment": "compartment_876", "id": "reaction_10475457", "reactome": "R-DME-5665727", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439139", "species_10475453" ], "products": [ "species_10475455" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "Q9VUC6", "FBgn0267795", "M9PE53", "FBgn0264272", "Q9VUC6", "FBgn0267795", "M9PE53", "FBgn0264272", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10475520": { "compartment": "compartment_70101", "id": "reaction_10475520", "reactome": "R-DME-5665989", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475514", "species_10434906" ], "products": [ "species_10475516" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202" ] }, "reaction_10464334": { "compartment": "compartment_70101", "id": "reaction_10464334", "reactome": "R-DME-2029460", "name": "PAK1 phosphorylates LIMK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447163" ], "products": [ "species_29370", "species_10447166" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "FBgn0283712", "FBgn0283712", "FBgn0267698" ] }, "reaction_10495682": { "compartment": "compartment_70101", "id": "reaction_10495682", "reactome": "R-DME-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446521", "species_10446509" ], "products": [ "species_10474308", "species_10446519" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "FBgn0267698" ] }, "reaction_10495684": { "compartment": "compartment_70101", "id": "reaction_10495684", "reactome": "R-DME-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446517", "species_10446509" ], "products": [ "species_10474306", "species_10446515" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "FBgn0267698" ] }, "reaction_10475643": { "compartment": "compartment_70101", "id": "reaction_10475643", "reactome": "R-DME-5669158", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_10464328" ], "products": [ "species_10475641" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "FBgn0086384", "Q24564", "FBgn0086384", "B7Z0W0", "FBgn0267698" ] }, "reaction_10464330": { "compartment": "compartment_70101", "id": "reaction_10464330", "reactome": "R-DME-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_10446509" ], "products": [ "species_10446525", "species_10446511" ], "modifiers": [ [ "species_10464328", "inhibitor" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698", "FBgn0086384" ] }, "reaction_10474313": { "compartment": "compartment_70101", "id": "reaction_10474313", "reactome": "R-DME-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474310" ], "products": [ "species_29370", "species_10447061", "species_10446509" ], "modifiers": [ [ "species_10474310", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME" ] }, "reaction_10475657": { "compartment": "compartment_70101", "id": "reaction_10475657", "reactome": "R-DME-5669250", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475647" ], "products": [ "species_10447061", "species_29370", "species_10475654" ], "modifiers": [ [ "species_10475647", "catalyst" ] ], "additional_components": [ "Q9VEN1", "FBgn0014141", "B7Z0W0", "FBgn0267698", "FBgn0267698", "Q9VEN1", "FBgn0014141", "Q9VEN1", "FBgn0014141", "B7Z0W0", "FBgn0267698" ] }, "reaction_10475622": { "compartment": "compartment_70101", "id": "reaction_10475622", "reactome": "R-DME-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475599" ], "products": [ "species_10475619", "species_29370" ], "modifiers": [ [ "species_10447065", "catalyst" ] ], "additional_components": [ "Q9VG88", "FBgn0053098", "P40423", "phospho-sqh", "P18432", "FBgn0002773", "Q9W4B1", "FBgn0085464", "Q9VQA5", "FBgn0031410", "P54357", "Mlc-c", "P06742", "FBgn0002772", "Q99323", "zip", "Q9W4B1", "FBgn0085464", "Q9VQA5", "FBgn0031410", "P54357", "Mlc-c", "P06742", "FBgn0002772", "Q99323", "zip", "Q9VG88", "FBgn0053098", "P40423", "phospho-sqh", "P18432", "FBgn0002773", "FBgn0267698" ] }, "reaction_10475637": { "compartment": "compartment_70101", "id": "reaction_10475637", "reactome": "R-DME-5668947", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475630" ], "products": [ "species_10475635", "species_29370" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "M9NEB2", "FBgn0005536", "P48462", "flw", "M9NEB2", "FBgn0005536", "P48462", "flw", "FBgn0267698" ] }, "reaction_10475649": { "compartment": "compartment_70101", "id": "reaction_10475649", "reactome": "R-DME-5669240", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447061", "species_10475645" ], "products": [ "species_10475647" ], "modifiers": [], "additional_components": [ "FBgn0267698", "Q9VEN1", "FBgn0014141", "Q9VEN1", "FBgn0014141", "B7Z0W0", "FBgn0267698" ] }, "reaction_10481326": { "compartment": "compartment_1222693", "id": "reaction_10481326", "reactome": "R-DME-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_1629751", "species_29370" ], "modifiers": [ [ "species_10481323", "catalyst" ] ], "additional_components": [ "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10464910": { "compartment": "compartment_876", "id": "reaction_10464910", "reactome": "R-DME-2130194", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464388", "species_113592" ], "products": [ "species_10464452", "species_29370" ], "modifiers": [ [ "species_10445197", "catalyst" ] ], "additional_components": [ "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "P40792", "RAC1_DROME", "species_29438", "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10464460": { "compartment": "compartment_70101", "id": "reaction_10464460", "reactome": "R-DME-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449184", "species_10464456" ], "products": [ "species_10464458" ], "modifiers": [], "additional_components": [ "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10464473": { "compartment": "compartment_70101", "id": "reaction_10464473", "reactome": "R-DME-2029469", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464452", "species_113592" ], "products": [ "species_29370", "species_10464428" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "P40417", "FBgn0003256" ] }, "reaction_10465367": { "compartment": "compartment_70101", "id": "reaction_10465367", "reactome": "R-DME-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464458" ], "products": [ "species_10464454", "species_10464494" ], "modifiers": [], "additional_components": [ "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_29370" ] }, "reaction_10464496": { "compartment": "compartment_70101", "id": "reaction_10464496", "reactome": "R-DME-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464494", "species_10442127" ], "products": [ "species_10461792" ], "modifiers": [], "additional_components": [ "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_29370", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046" ] }, "reaction_10475571": { "compartment": "compartment_70101", "id": "reaction_10475571", "reactome": "R-DME-5667008", "name": "RHOA:GTP binds RHPN1 or RHPN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434906", "species_10475565" ], "products": [ "species_10475569" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "FBgn0026374", "Q9XYY9", "FBgn0026374", "P48148", "Rho1", "species_29438" ] }, "reaction_10438409": { "compartment": "compartment_12045", "id": "reaction_10438409", "reactome": "R-DME-174368", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_162756" ], "products": [ "species_3499326", "species_174384" ], "modifiers": [ [ "species_10438406", "catalyst" ] ], "additional_components": [ "Q95YI5", "FBgn0042641" ] }, "reaction_10427874": { "compartment": "compartment_70101", "id": "reaction_10427874", "reactome": "R-DME-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548", "species_29494" ], "products": [ "species_111294", "species_29410" ], "modifiers": [ [ "species_10427871", "catalyst" ] ], "additional_components": [ "Q9VSW1", "FBgn0035978" ] }, "reaction_10437986": { "compartment": "compartment_70101", "id": "reaction_10437986", "reactome": "R-DME-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410", "species_29360" ], "products": [ "species_70106", "species_158601", "species_73473" ], "modifiers": [ [ "species_10437983", "catalyst" ] ], "additional_components": [ "O02373", "FBgn0261445" ] }, "reaction_10430076": { "compartment": "compartment_7660", "id": "reaction_10430076", "reactome": "R-DME-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429728", "species_10429536", "species_10429650", "species_10429733", "species_10429638", "species_10429655", "species_10429704", "species_10429640", "species_10429721", "species_10429723", "species_10429660", "species_10429645" ], "products": [ "species_10429735", "species_10429529" ], "modifiers": [], "additional_components": [ "FBgn0086707", "Q9VQK5", "FBgn0031492", "Q9VHC7", "FBgn0267790", "Q27294", "FBgn0285954", "Q9VEJ1", "FBgn0025571", "P24785", "FBgn0002774", "A1ZBW0", "FBgn0267791", "Q9VU43", "FBgn0036340", "Q9V3V0", "FBgn0028554", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "Q9V3W7", "FBgn0283477", "Q9V9K7", "FBgn0033062", "P19018", "FBgn0003742", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment": "compartment_7660", "id": "reaction_10435479", "reactome": "R-DME-156661", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430113", "species_10430097" ], "products": [ "species_10430117" ], "modifiers": [], "additional_components": [ "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "P26686", "FBgn0004587", "Q9VHC7", "FBgn0267790", "Q08473", "FBgn0263396", "A1ZBW0", "FBgn0267791", "Q7KU81", "FBgn0259935", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "P19018", "FBgn0003742", "Q8MZI3", "FBgn0035720", "M9NEH9", "FBgn0262737", "E1JGL8", "FBgn0050122", "Q9W0Q2", "FBgn0035141", "Q9V3T8", "FBgn0265298", "Q02427", "FBgn0260944", "Q9VHC0", "FBgn0037707", "Q95RI7", "FBgn0039977", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VEP9", "FBgn0266917", "O46106", "FBgn0014366", "Q9VU15", "FBgn0036314", "Q7PL83", "FBgn0086683", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", 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event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430081", "species_10430083", "species_10430088", "species_10430073", "species_10430093" ], "products": [ "species_10430097" ], "modifiers": [], "additional_components": [ "FBgn0034923", "FBgn0003742", "FBgn0033556", "Q9VES0", "FBgn0038454", "Q24562", "FBgn0005411", "Q9VQF5", "FBgn0031452", "Q94535", "FBgn0017457", "P26686", "FBgn0004587", "Q9VHC7", "FBgn0267790", "Q08473", "FBgn0263396", "A1ZBW0", "FBgn0267791", "Q7KU81", "FBgn0259935", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "P19018", "FBgn0003742", "Q8MZI3", "FBgn0035720", "M9NEH9", "FBgn0262737", "E1JGL8", "FBgn0050122", "Q9W0Q2", "FBgn0035141", "Q9V3T8", "FBgn0265298", "Q02427", "FBgn0260944", "Q9VHC0", "FBgn0037707", "Q95RI7", "FBgn0039977", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VEP9", "FBgn0266917", "O46106", 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"Q9VAY6", "FBgn0039558", "Q9V3B6", "FBgn0040235", "Q9VF55", "FBgn0038345", "Q9V3W7", "FBgn0283477", "Q960Q8", "FBgn0035027", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "P24785", "FBgn0002774", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q27294", "FBgn0285954", "Q94535", "FBgn0017457", "Q9VQF5", "FBgn0031452", "Q24562", "FBgn0005411", "Q9VES0", "FBgn0038454", "Q9VIZ3", "FBgn0086444" ] }, "reaction_10479004": { "compartment": "compartment_876", "id": "reaction_10479004", "reactome": "R-DME-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694509" ], "products": [ "species_422506", "species_70106", "species_76116" ], "modifiers": [ [ "species_10479001", "catalyst" ] ], "additional_components": [ "FBgn0034419" ] }, "reaction_10448215": { "compartment": "compartment_876", "id": "reaction_10448215", "reactome": "R-DME-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10448212", "catalyst" ] ], "additional_components": [ "FBgn0261244" ] }, "reaction_10478699": { "compartment": "compartment_20699", "id": "reaction_10478699", "reactome": "R-DME-5694418", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478691", "species_10478647", "species_10478684" ], "products": [ "species_10478697" ], "modifiers": [], "additional_components": [ "Q9W3N6", "FBgn0040087", "O18332", "FBgn0285937", "species_29438", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "Q9W3N6", "FBgn0040087", "O18332", "FBgn0285937", "species_29438", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855" ] }, "reaction_10478650": { "compartment": "compartment_13959", "id": "reaction_10478650", "reactome": "R-DME-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10478643" ], "products": [ "species_29420", "species_10478647" ], "modifiers": [ [ "species_10478643", "catalyst" ] ], "additional_components": [ "species_29420", "O18332", "FBgn0285937", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855", "O18332", "FBgn0285937", "species_29438", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855", "species_29420", "O18332", "FBgn0285937", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855" ] }, "reaction_10487625": { "compartment": "compartment_6791047", "id": "reaction_10487625", "reactome": "R-DME-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487621", "species_10486338" ], "products": [ "species_10487623" ], "modifiers": [], "additional_components": [ "FBgn0040005", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W5H8", "FBgn0040005" ] }, "reaction_10478773": { "compartment": "compartment_6791047", "id": "reaction_10478773", "reactome": "R-DME-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478768", "species_113592" ], "products": [ "species_10478736", "species_29372", "species_10478756", "species_10478741", "species_10478727", "species_10478746", "species_10478764", "species_10478751" ], "modifiers": [ [ "species_10478768", "catalyst" ] ], "additional_components": [ "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791", "Q23983", "FBgn0250791", "FBgn0011708", "FBgn0260857", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "FBgn0260856", "M9PGI6", "FBgn0260855", "FBgn0264978", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10478996": { "compartment": "compartment_6791047", "id": "reaction_10478996", "reactome": "R-DME-5694446", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478758", "species_10478892" ], "products": [ "species_10478994", "species_10478691", "species_10478684", "species_10478766" ], "modifiers": [], "additional_components": [ "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "Q9W3N6", "FBgn0040087", "M9PGI6", "FBgn0260855", "Q7JYA0", "FBgn0033873", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9V3A8", "FBgn0035909", "P49858", "FBgn0000339", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9W3N6", "FBgn0040087", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708" ] }, "reaction_10487628": { "compartment": "compartment_6791047", "id": "reaction_10487628", "reactome": "R-DME-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487623" ], "products": [ "species_10478404", "species_10487621" ], "modifiers": [ [ "species_10487623", "catalyst" ] ], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W5H8", "FBgn0040005", "species_29420", "O18332", "FBgn0285937", "FBgn0040005", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W5H8", "FBgn0040005" ] }, "reaction_10478770": { "compartment": "compartment_6791047", "id": "reaction_10478770", "reactome": "R-DME-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10478727", "species_10478766" ], "products": [ "species_10478768" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10442369": { "compartment": "compartment_70101", "id": "reaction_10442369", "reactome": "R-DME-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10442357" ], "products": [ "species_29420", "species_10442361" ], "modifiers": [ [ "species_10442366", "catalyst" ] ], "additional_components": [ "Q9VD29", "FBgn0038947", "species_29420", "Q9VD29", "FBgn0038947", "species_29438", "FBgn0031779" ] }, "reaction_10447503": { "compartment": "compartment_876", "id": "reaction_10447503", "reactome": "R-DME-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10447494", "catalyst" ] ], "additional_components": [ "FBgn0259214" ] }, "reaction_10455452": { "compartment": "compartment_70101", "id": "reaction_10455452", "reactome": "R-DME-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_947588", "species_113592" ], "products": [ "species_29372", "species_29370", "species_947594" ], "modifiers": [ [ "species_10455391", "catalyst" ] ], "additional_components": [ "species_33625", "species_1602375", "species_1602375", "species_33625", "B7YZF8", "FBgn0259221", "Q7KTG6", "FBgn0032120", "Q9VGD4", "FBgn0037989", "Q9VXG6", "FBgn0030747", "Q9VXG7", "FBgn0030746" ] }, "reaction_10447514": { "compartment": "compartment_114521", "id": "reaction_10447514", "reactome": "R-DME-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427899", "species_74016" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10447507", "catalyst" ] ], "additional_components": [] }, "reaction_10477993": { "compartment": "compartment_70101", "id": "reaction_10477993", "reactome": "R-DME-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29418", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1981162" ], "modifiers": [ [ "species_10477990", "catalyst" ] ], "additional_components": [ "FBgn0027582" ] }, "reaction_10455270": { "compartment": "compartment_20699", "id": "reaction_10455270", "reactome": "R-DME-936883", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_74016" ], "products": [ "species_29372", "species_29370", "species_167012" ], "modifiers": [ [ "species_10455267", "catalyst" ] ], "additional_components": [ "M9PG15", "FBgn0052451", "species_29926" ] }, "reaction_10455334": { "compartment": "compartment_876", "id": "reaction_10455334", "reactome": "R-DME-937311", "name": "ATP4A/12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_29356", "species_70106", "species_113592" ], "products": [ "species_351626", "species_29804", "species_29372", "species_29370" ], "modifiers": [ [ "species_10455331", "catalyst" ] ], "additional_components": [ "P13607", "FBgn0002921", "A8QI34", "FBgn0267363", "Q9VDY7", "FBgn0038691", "Q24046", "FBgn0015776", "Q9V3Q7", "FBgn0038690", "M9PDX8", "FBgn0032946", "Q7KT77", "FBgn0053310", "Q24048", "FBgn0015777" ] }, "reaction_10448436": { "compartment": "compartment_12045", "id": "reaction_10448436", "reactome": "R-DME-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_74016" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10448412", "catalyst" ], [ "species_10448434", "catalyst" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607" ] }, "reaction_10478001": { "compartment": "compartment_70101", "id": "reaction_10478001", "reactome": "R-DME-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5692450" ], "products": [ "species_29372", "species_29370", "species_5692484" ], "modifiers": [ [ "species_10477998", "catalyst" ] ], "additional_components": [ "FBgn0052000" ] }, "reaction_10448234": { "compartment": "compartment_876", "id": "reaction_10448234", "reactome": "R-DME-426086", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_188972", "species_74113" ], "products": [ "species_29804", "species_83910", "species_352022" ], "modifiers": [ [ "species_10448231", "catalyst" ] ], "additional_components": [ "M9PI37", "FBgn0036279", "Q9VNC7", "FBgn0051547" ] }, "reaction_10448243": { "compartment": "compartment_876", "id": "reaction_10448243", "reactome": "R-DME-426130", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_74113" ], "products": [ "species_83910", "species_352022" ], "modifiers": [ [ "species_10448240", "catalyst" ] ], "additional_components": [ "Q9VNC7", "FBgn0051547", "M9PI37", "FBgn0036279" ] }, "reaction_10464875": { "compartment": "compartment_70101", "id": "reaction_10464875", "reactome": "R-DME-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464873" ], "products": [ "species_10443056" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016" ] }, "reaction_10443076": { "compartment": "compartment_70101", "id": "reaction_10443076", "reactome": "R-DME-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443056" ], "products": [ "species_10443074" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VLW8", "FBgn0031951" ] }, "reaction_10431293": { "compartment": "compartment_5460", "id": "reaction_10431293", "reactome": "R-DME-73916", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559" ], "products": [ "species_29374", "species_73871" ], "modifiers": [ [ "species_10428434", "catalyst" ] ], "additional_components": [ "Q9W3N9", "FBgn0029969" ] }, "reaction_10431485": { "compartment": "compartment_5460", "id": "reaction_10431485", "reactome": "R-DME-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_113559", "species_73909" ], "modifiers": [ [ "species_10431482", "catalyst" ] ], "additional_components": [ "Q9VM58", "FBgn0031877" ] }, "reaction_10431291": { "compartment": "compartment_5460", "id": "reaction_10431291", "reactome": "R-DME-73912", "name": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_73909", "species_29362" ], "products": [ "species_113526", "species_73911" ], "modifiers": [ [ "species_10431288", "catalyst" ] ], "additional_components": [ "Q7K3N4", "FBgn0033679" ] }, "reaction_10491097": { "compartment": "compartment_5460", "id": "reaction_10491097", "reactome": "R-DME-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10491094", "catalyst" ] ], "additional_components": [ "FBgn0039184" ] }, "reaction_10479990": { "compartment": "compartment_70101", "id": "reaction_10479990", "reactome": "R-DME-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10479987", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VM58", "FBgn0031877" ] }, "reaction_10431301": { "compartment": "compartment_5460", "id": "reaction_10431301", "reactome": "R-DME-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10431298", "catalyst" ] ], "additional_components": [ "FBgn0010611" ] }, "reaction_10479039": { "compartment": "compartment_20699", "id": "reaction_10479039", "reactome": "R-DME-5694487", "name": "A4GNT transfers GlcNAc to core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454881" ], "products": [ "species_10479031", "species_205687" ], "modifiers": [ [ "species_10479036", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "FBgn0031491" ] }, "reaction_10454637": { "compartment": "compartment_20699", "id": "reaction_10454637", "reactome": "R-DME-913675", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10454542" ], "products": [ "species_10454561", "species_205687" ], "modifiers": [ [ "species_10454634", "catalyst" ] ], "additional_components": [ "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9Y117", "FBgn0027558", "Q6WV17", "FBgn0031681", "Q8MV48", "FBgn0030930", "Q6WV19", "FBgn0031530", "Q6WV20", "FBgn0034025", "Q8MYY6", "FBgn0039596", "Q8MRC9", "FBgn0050463", "Q8MVS5", "FBgn0001970" ] }, "reaction_10462333": { "compartment": "compartment_20699", "id": "reaction_10462333", "reactome": "R-DME-1964505", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454561", "species_735682" ], "products": [ "species_205687", "species_10454862" ], "modifiers": [ [ "species_10462330", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VQH4", "FBgn0031466", "A8JNT3", "FBgn0085480", "Q9VQI0", "FBgn0031472", "Q7K237", "FBgn0032078", "A8JNT2", "FBgn0085481", "Q9VQH7", "FBgn0031469", "Q7JRF9", "FBgn0033271", "Q9W0L4", "FBgn0054056", "Q9VQH6", "FBgn0031468", "Q2PE08", "FBgn0054057", "Q9VWM1", "FBgn0030984" ] }, "reaction_10479773": { "compartment": "compartment_20699", "id": "reaction_10479773", "reactome": "R-DME-6786012", "name": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454881", "species_741440" ], "products": [ "species_742343", "species_10479764" ], "modifiers": [ [ "species_10479770", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VMC4", "FBgn0031826", "Q9VMC3", "FBgn0051637" ] }, "reaction_10462269": { "compartment": "compartment_17963", "id": "reaction_10462269", "reactome": "R-DME-1964501", "name": "Addition of galactose to Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10454714" ], "products": [ "species_10462264", "species_205687" ], "modifiers": [ [ "species_10462266", "catalyst" ] ], "additional_components": [ "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10454716": { "compartment": "compartment_17963", "id": "reaction_10454716", "reactome": "R-DME-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454561" ], "products": [ "species_10454714", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004" ] }, "reaction_10454843": { "compartment": "compartment_20699", "id": "reaction_10454843", "reactome": "R-DME-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454561" ], "products": [ "species_205687", "species_10454735" ], "modifiers": [ [ "species_10454840", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VZA6", "FBgn0035558", "Q95RP8", "FBgn0040373", "A1Z8R6", "FBgn0053145", "A1Z8R5", "FBgn0050037", "A1Z8R4", "FBgn0050036", "Q9VLT0", "FBgn0031986", "Q9VLS8", "FBgn0031988" ] }, "reaction_10454695": { "compartment": "compartment_17963", "id": "reaction_10454695", "reactome": "R-DME-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454561", "species_735682" ], "products": [ "species_10454693", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167" ] }, "reaction_10454902": { "compartment": "compartment_17963", "id": "reaction_10454902", "reactome": "R-DME-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10454561" ], "products": [ "species_10454900", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167" ] }, "reaction_10454674": { "compartment": "compartment_17963", "id": "reaction_10454674", "reactome": "R-DME-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454561" ], "products": [ "species_10454672", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167" ] }, "reaction_10470740": { "compartment": "compartment_12045", "id": "reaction_10470740", "reactome": "R-DME-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470732" ], "products": [ "species_10470564" ], "modifiers": [ [ "species_10470737", "catalyst" ] ], "additional_components": [ "Q9VM97", "FBgn0031850", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9W493", "FBgn0029791", "Q9W493", "FBgn0029791", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9VM97", "FBgn0031850", "FBgn0027791" ] }, "reaction_10470658": { "compartment": "compartment_12045", "id": "reaction_10470658", "reactome": "R-DME-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470564", "species_173594" ], "products": [ "species_158602", "species_10470650" ], "modifiers": [ [ "species_10470655", "catalyst" ] ], "additional_components": [ "Q9W493", "FBgn0029791", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9VM97", "FBgn0031850", "Q9W493", "FBgn0029791", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9VM97", "FBgn0031850", "FBgn0031765" ] }, "reaction_10449358": { "compartment": "compartment_984", "id": "reaction_10449358", "reactome": "R-DME-432164", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10449355", "catalyst" ], [ "species_9635195", "inhibitor" ] ], "additional_components": [ "Q7KRY7", "FBgn0263289", "P18091", "FBgn0000667", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "Q00168", "FBgn0264607", "CHEBI:16523", "species_29424", "species_210382" ] }, "reaction_10449740": { "compartment": "compartment_876", "id": "reaction_10449740", "reactome": "R-DME-438037", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10446948", "catalyst" ], [ "species_10449738", "catalyst" ] ], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q7KRY7", "FBgn0263289", "P18091", "FBgn0000667", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "CHEBI:16523", "species_29424", "species_210382" ] }, "reaction_10497396": { "compartment": "compartment_12045", "id": "reaction_10497396", "reactome": "R-DME-9609742", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497390", "species_10497392" ], "products": [ "species_10497394" ], "modifiers": [], "additional_components": [ "FBgn0010399", "FBgn0053513", "Q9W581", "FBgn0053513", "Q24418", "FBgn0010399" ] }, "reaction_10497508": { "compartment": "compartment_12045", "id": "reaction_10497508", "reactome": "R-DME-9610750", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497506" ], "products": [ "species_10449322" ], "modifiers": [], "additional_components": [ "Q9W581", "FBgn0053513", "Q24418", "FBgn0010399", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513" ] }, "reaction_10493706": { "compartment": "compartment_70101", "id": "reaction_10493706", "reactome": "R-DME-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434305", "species_30389" ], "products": [ "species_10434307" ], "modifiers": [], "additional_components": [ "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "species_30389", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243" ] }, "reaction_10434269": { "compartment": "compartment_7660", "id": "reaction_10434269", "reactome": "R-DME-111915", "name": "CAMK4 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10434260" ], "products": [ "species_113582", "species_10434266" ], "modifiers": [ [ "species_10434260", "catalyst" ] ], "additional_components": [ "Q7PLI7", "FBgn0261387", "species_74016", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q7PLI7", "FBgn0261387", "species_74016", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q7PLI7", "FBgn0261387", "species_74016", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273" ] }, "reaction_10435620": { "compartment": "compartment_70101", "id": "reaction_10435620", "reactome": "R-DME-157849", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435618", "species_10430440", "species_10430463" ], "products": [ "species_10430440", "species_10430508" ], "modifiers": [], "additional_components": [ "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10435555": { "compartment": "compartment_70101", "id": "reaction_10435555", "reactome": "R-DME-156808", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430440", "species_10435546", "species_10435551", "species_10430463" ], "products": [ "species_10435553", "species_10430440" ], "modifiers": [], "additional_components": [ "FBgn0026250", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0265297", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P21187", "FBgn0265297", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0026250" ] }, "reaction_10497375": { "compartment": "compartment_13231", "id": "reaction_10497375", "reactome": "R-DME-9604308", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497365" ], "products": [ "species_10443303" ], "modifiers": [ [ "species_10497373", "inhibitor" ] ], "additional_components": [ "FBgn0051665", "FBgn0051665", "P29310", "14-3-3zeta", "Q7KU08", "FBgn0051665" ] }, "reaction_10446682": { "compartment": "compartment_984", "id": "reaction_10446682", "reactome": "R-DME-390886", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445670", "species_390899" ], "products": [ "species_10445672" ], "modifiers": [], "additional_components": [ "FBgn0000037", "species_390899", "P16395", "FBgn0000037" ] }, "reaction_10498568": { "compartment": "compartment_984", "id": "reaction_10498568", "reactome": "R-DME-9692880", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10498564" ], "products": [ "species_10498566" ], "modifiers": [], "additional_components": [ "FBgn0000037", "P16395", "FBgn0000037", "species_390899" ] }, "reaction_10496054": { "compartment": "compartment_70101", "id": "reaction_10496054", "reactome": "R-DME-9009308", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496029", "species_10426987" ], "products": [ "species_10456460", "species_10496051" ], "modifiers": [ [ "species_10496029", "catalyst" ] ], "additional_components": [ "Q9XYW6", "FBgn0027052", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0027052", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "Q9XYW6", "FBgn0027052", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10492551": { "compartment": "compartment_7660", "id": "reaction_10492551", "reactome": "R-DME-8939706", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10492520" ], "products": [ "species_10427449", "species_10492548" ], "modifiers": [ [ "species_10492520", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10496056": { "compartment": "compartment_70101", "id": "reaction_10496056", "reactome": "R-DME-9009309", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496027", "species_10456460" ], "products": [ "species_10496029" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "FBgn0027052", "Q9XYW6", "FBgn0027052", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10492553": { "compartment": "compartment_7660", "id": "reaction_10492553", "reactome": "R-DME-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492548" ], "products": [ "species_10427430" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10492522": { "compartment": "compartment_7660", "id": "reaction_10492522", "reactome": "R-DME-8939688", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491656", "species_10427449" ], "products": [ "species_10492520" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_538904": { "compartment": "compartment_7660", "id": "reaction_538904", "reactome": "R-DME-538904", "name": "Phosphorylated PER binds to CLK", "reversible": "false", "notes": "After Timeless (TIM) and Period (PER) reform their heterodimer, PER binds to the E-box bound Clock (CLK) protein. Transcription of the per, tim, vri, and Pdp1 target genes is now deactivated. It appears that PER directly binds to CLK, whereas itself and TIM do not bind to Cycle (CYC). PER binding to CLK is in itself not sufficient for inhibition.", "reactants": [ "species_881986", "species_881995" ], "products": [ "species_882012" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_538891": { "compartment": "compartment_7660", "id": "reaction_538891", "reactome": "R-DME-538891", "name": "CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes", "reversible": "false", "notes": "The deactivation of the Clock (CLK):Cycle (CYC) heterodimer and subsequent deactivation of the per, tim, vri, and Pdp1 target genes causes the CLK:CYC heterodimer to be released from its binding to its target genes, sequestered in a stable complex with PER and TIM to reinforce the transcription inhibition. Towards the end of the night Period (PER) and Timeless (TIM) proteins are at their peak level.", "reactants": [ "species_881925" ], "products": [ "species_881962", "species_29428" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC" ] }, "reaction_432513": { "compartment": "compartment_7660", "id": "reaction_432513", "reactome": "R-DME-432513", "name": "CLK is phosphorylated by DCO", "reversible": "false", "notes": "Clock (CLK) protein is now phosphorylated on unknown serine/threonine residues by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO). It is not yet known whether other kinases are involved in phosphorylating CLK, potentially brought to there via interactions with DCO and Period (PER) acting as scaffolding proteins. There is also evidence from mammalian systems that chromatin remodelling factors are brought in by the PER scaffold and are responsible for a sustained state of transcription inhibition in these genes.", "reactants": [ "species_29358", "species_882012" ], "products": [ "species_113582", "species_881925" ], "modifiers": [ [ "species_882012", "catalyst" ] ], "additional_components": [ "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432381": { "compartment": "compartment_7660", "id": "reaction_432381", "reactome": "R-DME-432381", "name": "PDP1 replaces VRI as binder to Clk and cry genes", "reversible": "false", "notes": "PAR domain protein-1 (PDP1) levels reach their peak between mid to late night. Vrille (VRI) levels decline during this time due to TIM:PER:DCO mediated repression of Clock (CLK) driven vri transcription. The decreasing ratio of VRI/PDP1 levels favours binding of PDP1 over VRI to the V/P boxes resulting in activation of Clk and cry transcription.", "reactants": [ "species_881990", "species_432423" ], "products": [ "species_432467", "species_881966" ], "modifiers": [], "additional_components": [ "Q9VMS4", "VRI", "Q24217", "PDP1" ] }, "reaction_538900": { "compartment": "compartment_7660", "id": "reaction_538900", "reactome": "R-DME-538900", "name": "Phosphorylated PER rebinds to phosphorylated TIM", "reversible": "false", "notes": "Once in the nucleus, phosphorylated Timeless (TIM) and Period (PER) reform their heterodimer.", "reactants": [ "species_881991", "species_432657" ], "products": [ "species_881995" ], "modifiers": [], "additional_components": [ "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO" ] }, "reaction_432516": { "compartment": "compartment_7660", "id": "reaction_432516", "reactome": "R-DME-432516", "name": "CLK and CYC bind to form a heterodimer", "reversible": "false", "notes": "The basic-helix-loop-helix PAS (PER-ARNT-SIM) domain transcription factors, Clock (CLK) and Cycle (CYC) bind and form a heterodimer.", "reactants": [ "species_432489", "species_432557" ], "products": [ "species_432591" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432436": { "compartment": "compartment_7660", "id": "reaction_432436", "reactome": "R-DME-432436", "name": "CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes", "reversible": "false", "notes": "At midday, the Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target genes, per, tim, vri, and Pdp1. Transcription of these genes is now activated.", "reactants": [ "species_432591", "species_29428" ], "products": [ "species_881986" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432593": { "compartment": "compartment_70101", "id": "reaction_432593", "reactome": "R-DME-432593", "name": "Cytosolic JET binds to CRY, facilitating its ubiquitination", "reversible": "false", "notes": "After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY), facilitating its ubiquitination, marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.", "reactants": [ "species_206204", "species_432571", "species_432574" ], "products": [ "species_432576" ], "modifiers": [ [ "species_432571", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "O77059", "CRY", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_432428": { "compartment": "compartment_70101", "id": "reaction_432428", "reactome": "R-DME-432428", "name": "Cytosolic CRY is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated cryptochrome (CRY) is degraded by the 26S proteasome.", "reactants": [ "species_432576" ], "products": [ "species_206204", "species_432571" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "O77059", "CRY", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_432652": { "compartment": "compartment_7660", "id": "reaction_432652", "reactome": "R-DME-432652", "name": "Nuclear CRY is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated cryptochrome (CRY) is degraded by the 26S proteasome.", "reactants": [ "species_432418" ], "products": [ "species_432393", "species_216110" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "O77059", "CRY", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432378": { "compartment": "compartment_7660", "id": "reaction_432378", "reactome": "R-DME-432378", "name": "Nuclear JET binds CRY, facilitating its ubiquitination", "reversible": "false", "notes": "After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY), facilitating its ubiquitination and marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.", "reactants": [ "species_432393", "species_216110", "species_432582" ], "products": [ "species_432418" ], "modifiers": [ [ "species_432393", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O77059", "CRY", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET" ] }, "reaction_432510": { "compartment": "compartment_7660", "id": "reaction_432510", "reactome": "R-DME-432510", "name": "CLK is degraded by the 26S proteasome", "reversible": "false", "notes": "Hyperphosphorylated Clock (CLK) is degraded by the 26S proteasome via an unknown intermediate mechanism.", "reactants": [ "species_432621" ], "products": [ "species_432489" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432455": { "compartment": "compartment_7660", "id": "reaction_432455", "reactome": "R-DME-432455", "name": "Nuclear PER is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Period (PER) is degraded by the 26S proteasome.", "reactants": [ "species_882001" ], "products": [ "species_216110", "species_432621", "species_432399", "species_432469" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "O44382", "SLMB", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61734", "CYC", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61735", "Phospho CLK", "O61734", "CYC", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432483": { "compartment": "compartment_7660", "id": "reaction_432483", "reactome": "R-DME-432483", "name": "SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination", "reversible": "false", "notes": "During the day, with levels of its stabilising partner Timeless (TIM) drastically reduced by light, hyperphosphorylated Period (PER) becomes a target for the F-box containing protein, supernumerary limbs (SLMB). Ser47 phosphorylation of Period (PER) appears to be the trigger for SLMB to bind phosphorylated PER, facilitating its ubiquitination and marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for PER degradation are the same.", "reactants": [ "species_216110", "species_881927", "species_432469" ], "products": [ "species_882001" ], "modifiers": [ [ "species_432469", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "O61734", "CYC", "O44382", "SLMB", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61734", "CYC" ] }, "reaction_432411": { "compartment": "compartment_70101", "id": "reaction_432411", "reactome": "R-DME-432411", "name": "SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination", "reversible": "false", "notes": "During the day, with levels of its stabilising partner Timeless (TIM) drastically reduced by light, hyperphosphorylated Period (PER) becomes a target for the F-box containing protein, supernumerary limbs (SLMB). Ser47 phosphorylation of Period (PER) appears to be the trigger for SLMB to bind and facilitate ubiquitination of phosphorylated PER, marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for PER degradation are the same.", "reactants": [ "species_206204", "species_881987", "species_206299" ], "products": [ "species_881958" ], "modifiers": [ [ "species_206299", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O44382", "SLMB", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_432361": { "compartment": "compartment_70101", "id": "reaction_432361", "reactome": "R-DME-432361", "name": "Cytosolic PER is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Period (PER) is degraded by the 26S proteasome.", "reactants": [ "species_881958" ], "products": [ "species_206204", "species_206299", "species_205729" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O44382", "SLMB", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_432527": { "compartment": "compartment_7660", "id": "reaction_432527", "reactome": "R-DME-432527", "name": "Nuclear PP2A dephosphorylates phosphorylated PER", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Widerborst (WDB), helps stabilise hyperphosphorylated Period (PER) by dephosphorylating it and so prevent it from degradation. PP2A also seems to speed up nuclear import of PER. This is probably a secondary effect of stabilising PER.", "reactants": [ "species_881962" ], "products": [ "species_113550", "species_881965" ], "modifiers": [ [ "species_432603", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "P23696", "mts", "Q9VB23", "WDB", "P36179", "Pp2A-29B" ] }, "reaction_432556": { "compartment": "compartment_70101", "id": "reaction_432556", "reactome": "R-DME-432556", "name": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Twins (TWS), helps stabilise hyperphosphorylated Period (PER), within the PER:DCO complex, by dephosphorylating it and so prevent it from degradation. PP2A likely dephosphorylates the site phosphorylated by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) as it stabilises PER.", "reactants": [ "species_881987" ], "products": [ "species_432347", "species_29372" ], "modifiers": [ [ "species_206938", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_538822": { "compartment": "compartment_70101", "id": "reaction_538822", "reactome": "R-DME-538822", "name": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Twins (TWS), helps stabilise hyperphosphorylated Period (PER), within the PER:DCO complex, by dephosphorylating it and so prevent it from degradation. PP2A likely dephosphorylates the site phosphorylated by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) as it stabilises PER.", "reactants": [ "species_881967" ], "products": [ "species_29372", "species_432413" ], "modifiers": [ [ "species_206938", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_538824": { "compartment": "compartment_70101", "id": "reaction_538824", "reactome": "R-DME-538824", "name": "PP1 binds to phosphorylated TIM in complex with PER", "reversible": "false", "notes": "The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).", "reactants": [ "species_881944", "species_432645" ], "products": [ "species_882002" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "O76324", "DCO", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM" ] }, "reaction_432533": { "compartment": "compartment_70101", "id": "reaction_432533", "reactome": "R-DME-432533", "name": "PP1 binds to phosphorylated TIM", "reversible": "false", "notes": "The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).", "reactants": [ "species_432363", "species_432645" ], "products": [ "species_432543" ], "modifiers": [], "additional_components": [ "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P49021", "TIM" ] }, "reaction_538832": { "compartment": "compartment_70101", "id": "reaction_538832", "reactome": "R-DME-538832", "name": "PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO", "reversible": "false", "notes": "The protein phosphatase, PP1, dephosphorylates and stabilises Timeless (TIM) which helps promote the accumulation of Period (PER).", "reactants": [ "species_882002" ], "products": [ "species_29372", "species_881912", "species_432645" ], "modifiers": [ [ "species_882002", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P49021", "TIM", "P07663", "Phospho (multi-site 2) PER", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "O76324", "DCO", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM" ] }, "reaction_432427": { "compartment": "compartment_70101", "id": "reaction_432427", "reactome": "R-DME-432427", "name": "PP1 dephosphorylates phosphorylated TIM", "reversible": "false", "notes": "The protein phosphatase, PP1, dephosphorylates and stabilises Timeless (TIM) which helps promote the accumulation of Period (PER).", "reactants": [ "species_432543" ], "products": [ "species_29372", "species_432355", "species_432645" ], "modifiers": [ [ "species_432543", "catalyst" ] ], "additional_components": [ "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P49021", "TIM", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P49021", "TIM" ] }, "reaction_432642": { "compartment": "compartment_13231", "id": "reaction_432642", "reactome": "R-DME-432642", "name": "Phosphorylated TIM transports from the cytosol to the nucleus", "reversible": "false", "notes": "After the phosphorylated Period (PER):Discs Overgrown (DCO) complex has entered the nucleus, phosphorylated Timeless (TIM) does the same. The time frame between the two events appears to be variable, depending on the type of neuronal clock cell, and can be up to a few hours later. It is currently not known whether casein kinase II (CK2) is bound to PER and/or TIM and whether it travels with either from the cytosol to the nucleus.", "reactants": [ "species_432363" ], "products": [ "species_432657" ], "modifiers": [], "additional_components": [] }, "reaction_432544": { "compartment": "compartment_13231", "id": "reaction_432544", "reactome": "R-DME-432544", "name": "Phosphorylated PER transports from the cytosol to the nucleus", "reversible": "false", "notes": "Phosphorylated Period (PER):Discs Overgrown (DCO) complex is imported into the nucleus from the cytosol.", "reactants": [ "species_882007" ], "products": [ "species_881991" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO" ] }, "reaction_432371": { "compartment": "compartment_7660", "id": "reaction_432371", "reactome": "R-DME-432371", "name": "CRY is activated by light and binds to phosphorylated nuclear TIM", "reversible": "false", "notes": "At dawn, a light-induced conformational change in the blue-light photoreceptor cryptochrome (CRY) promotes the formation of a complex with phosphorylated Timeless (TIM). In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for TIM degradation are the same. Also, in flies kept in constant darkness for many days, TIM levels still undergo daily oscillations, although not as robust as in light-dark cycles. The mechanism that drives daily cycles in TIM levels during extended periods in complete darkness is not clear.", "reactants": [ "species_881962", "species_432582" ], "products": [ "species_881922", "species_881927" ], "modifiers": [ [ "species_432508", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "O77059", "CRY", "P49021", "TIM", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "O61734", "CYC" ] }, "reaction_432401": { "compartment": "compartment_70101", "id": "reaction_432401", "reactome": "R-DME-432401", "name": "JET binds cytosolic TIM, facilitating its ubiquitination", "reversible": "false", "notes": "There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and TIM helps promote the interaction between the F-box domain containing protein JET with TIM. This interaction targets TIM for ubiquitination, marking it for processing by the 26S proteasome.", "reactants": [ "species_206204", "species_432571", "species_881918" ], "products": [ "species_881984", "species_432574" ], "modifiers": [ [ "species_432571", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P49021", "TIM", "O77059", "CRY", "P49021", "TIM", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_432426": { "compartment": "compartment_70101", "id": "reaction_432426", "reactome": "R-DME-432426", "name": "CRY is activated by light and binds to cytosolic TIM", "reversible": "false", "notes": "At dawn, a light-induced conformational change in the blue-light photoreceptor cryptochrome (CRY) promotes the formation of a complex with Timeless (TIM). In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for TIM degradation are the same. Also, in flies kept in constant darkness for many days, TIM levels still undergo daily oscillations, although not as robust as in light-dark cycles. The mechanism that drives daily cycles in TIM levels during extended periods in complete darkness is not clear.", "reactants": [ "species_432574", "species_432355" ], "products": [ "species_881918" ], "modifiers": [ [ "species_432604", "catalyst" ] ], "additional_components": [ "P49021", "TIM", "O77059", "CRY" ] }, "reaction_432507": { "compartment": "compartment_70101", "id": "reaction_432507", "reactome": "R-DME-432507", "name": "Cytosolic TIM is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.", "reactants": [ "species_881984" ], "products": [ "species_206204", "species_432571" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "P49021", "TIM", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_432424": { "compartment": "compartment_7660", "id": "reaction_432424", "reactome": "R-DME-432424", "name": "JET binds phosphorylated nuclear TIM, facilitating its ubiquitination", "reversible": "false", "notes": "There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and phosphorylated TIM helps promote the interaction between the F-box domain containing protein JET with phosphorylated TIM, facilitating ubiquitination of the latter protein, marking it for processing by the 26S proteasome.", "reactants": [ "species_432393", "species_881922", "species_216110" ], "products": [ "species_882000", "species_432582" ], "modifiers": [ [ "species_432393", "catalyst" ] ], "additional_components": [ "O77059", "CRY", "P49021", "TIM", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P49021", "TIM", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET" ] }, "reaction_432521": { "compartment": "compartment_7660", "id": "reaction_432521", "reactome": "R-DME-432521", "name": "Nuclear TIM is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.", "reactants": [ "species_882000" ], "products": [ "species_432393", "species_216110" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "P49021", "TIM", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432487": { "compartment": "compartment_7660", "id": "reaction_432487", "reactome": "R-DME-432487", "name": "CWO binds to cwo gene and represses transcription", "reversible": "false", "notes": "Clockwork Orange (CWO) binds to the E-box of its own gene, cwo, and represses it's own transcription in a negative feedback loop.", "reactants": [ "species_29428", "species_432566" ], "products": [ "species_881926" ], "modifiers": [], "additional_components": [ "Q9VGZ5", "CWO" ] }, "reaction_432520": { "compartment": "compartment_7660", "id": "reaction_432520", "reactome": "R-DME-432520", "name": "CLK:CYC heterodimer binds to cwo gene and activates transcription", "reversible": "false", "notes": "The Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target gene, cwo. Transcription of cwo is now activated.", "reactants": [ "species_432591", "species_29428" ], "products": [ "species_881986" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432647": { "compartment": "compartment_70101", "id": "reaction_432647", "reactome": "R-DME-432647", "name": "Phosphorylated PER binds to TIM", "reversible": "false", "notes": "After dusk, per and tim genes continue to be transcribed and their mRNAs reach peak levels between during the early part of the night. Timeless (TIM) protein is stable in the dark and so begins to accumulate and forms a complex with Period (PER) and Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). TIM stabilises PER despite the continuous attentions of casein kinase II (CK2) and DCO. As a result, PER and TIM accumulate to high levels during the middle of the night.", "reactants": [ "species_881987", "species_432355" ], "products": [ "species_881967" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM" ] }, "reaction_432535": { "compartment": "compartment_70101", "id": "reaction_432535", "reactome": "R-DME-432535", "name": "TIM is phosphorylated by CK2", "reversible": "false", "notes": "Timeless (TIM) is phosphorylated on unknown serine/threonine residues by casein kinase II (CK2). CK2 phosphorylation appears to be important for subsequent nuclear entry of TIM.", "reactants": [ "species_113592", "species_881912" ], "products": [ "species_29370", "species_881944" ], "modifiers": [ [ "species_206956", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P49021", "TIM", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "P11346", "Raf", "Q7KNQ9", "cnk", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P92177", "14-3-3epsilon", "Q9V9J3", "phospho-Src42A", "Q8ML92", "AVE", "P08646", "RAS85D", "species_29438", "Q24170", "Phospho KSR" ] }, "reaction_432464": { "compartment": "compartment_70101", "id": "reaction_432464", "reactome": "R-DME-432464", "name": "Phosphorylated TIM:PER heterodimer dissociate", "reversible": "false", "notes": "The phosphorylation of Timeless (TIM) and Period (PER) by casein kinase II (CK2) appears to be the trigger for their nuclear entry. However, before this occurs, phosphorylated TIM dissociates from the PER:Discs Overgrown (DCO) complex.", "reactants": [ "species_881944" ], "products": [ "species_432363", "species_882007" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER" ] }, "reaction_432590": { "compartment": "compartment_70101", "id": "reaction_432590", "reactome": "R-DME-432590", "name": "Phosphorylated PER is phosphorylated by CK2", "reversible": "false", "notes": "Phosphorylated Period (PER) is phosphorylated on serine residues 149, 151, 153, by casein kinase II (CK2). CK2 phosphorylation appears to be important for subsequent nuclear entry of PER.", "reactants": [ "species_113592", "species_881967" ], "products": [ "species_29370", "species_881912" ], "modifiers": [ [ "species_206956", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P49021", "TIM", "P07663", "Phospho (multi-site 2) PER", "P11346", "Raf", "Q7KNQ9", "cnk", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P92177", "14-3-3epsilon", "Q9V9J3", "phospho-Src42A", "Q8ML92", "AVE", "P08646", "RAS85D", "species_29438", "Q24170", "Phospho KSR" ] }, "reaction_432559": { "compartment": "compartment_70101", "id": "reaction_432559", "reactome": "R-DME-432559", "name": "PER is phosphorylated by DCO", "reversible": "false", "notes": "Period (PER) is phosphorylated on between 15-20 individual serine and threonine sites by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). During the day, when light activated regulation of Timeless (TIM) occurs and its levels are low, phosphorylated PER is susceptible to supernumerary limbs (SLMB) mediated ubiquitination and degradation. Ser47 and possibly other phosphorylated residues nearby are key phospho-signals on PER mediating the binding of SLMB to PER.", "reactants": [ "species_432347", "species_113592" ], "products": [ "species_881987", "species_29370" ], "modifiers": [ [ "species_206741", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_881988": { "compartment": "compartment_70101", "id": "reaction_881988", "reactome": "R-DME-881988", "name": "CRY is phosphorylated by SGG", "reversible": "false", "notes": "The blue-light photoreceptor cryptochrome (CRY) is phosphorylated on unknown serine/threonine residues by GSK3beta kinase orthologue, Shaggy (SGG). Phosphorylation appears to attenuate the function of CRY and it doesn't degrade Timeless (TIM). Earlier studies suggested that the effect of SGG on the light-mediated degradation of TIM was due to direct phosphorylation of TIM by SGG (Martinek et al., 2001), however, more recent experiments suggest the actual target of SGG in this pathway is CRY (Storelu et al., 2007).", "reactants": [ "species_113592", "species_432574" ], "products": [ "species_29370", "species_882013" ], "modifiers": [ [ "species_206898", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_538835": { "compartment": "compartment_70101", "id": "reaction_538835", "reactome": "R-DME-538835", "name": "PER binds to DCO", "reversible": "false", "notes": "The Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT) forms a complex with Period (PER).", "reactants": [ "species_432515", "species_205729" ], "products": [ "species_432347" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER" ] }, "reaction_432537": { "compartment": "compartment_7660", "id": "reaction_432537", "reactome": "R-DME-432537", "name": "PP2A dephosphorylates phosphorylated CLK", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Widerborst (WDB), helps stabilise hyperphosphorylated Clock (CLK) by dephosphorylating it and so prevent it from degradation. CLK levels remain relatively constant because hypophosphorylated CLK is generated by de novo synthesis or by dephosphorylation of existent hyperphosphorylated CLK.", "reactants": [ "species_432621" ], "products": [ "species_113550", "species_432591" ], "modifiers": [ [ "species_432603", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "O61734", "CYC", "P23696", "mts", "Q9VB23", "WDB", "P36179", "Pp2A-29B" ] }, "reaction_10456268": { "compartment": "compartment_876", "id": "reaction_10456268", "reactome": "R-DME-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437245", "species_983438" ], "products": [ "species_10456122" ], "modifiers": [], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10456252": { "compartment": "compartment_876", "id": "reaction_10456252", "reactome": "R-DME-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437285", "species_983438" ], "products": [ "species_10456083" ], "modifiers": [], "additional_components": [ "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10438059": { "compartment": "compartment_984", "id": "reaction_10438059", "reactome": "R-DME-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10437271" ], "products": [ "species_10438057" ], "modifiers": [], "additional_components": [ "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10431519": { "compartment": "compartment_70101", "id": "reaction_10431519", "reactome": "R-DME-74242", "name": "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500172" ], "products": [ "species_113599", "species_500244" ], "modifiers": [ [ "species_10431516", "catalyst" ] ], "additional_components": [ "CHEBI:28997", "species_83927", "CHEBI:28542", "species_112016", "Q9W1K6", "FBgn0034898", "M9PE19", "FBgn0035348" ] }, "reaction_10431551": { "compartment": "compartment_70101", "id": "reaction_10431551", "reactome": "R-DME-74255", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_83956" ], "products": [ "species_31633", "species_30064" ], "modifiers": [ [ "species_10431548", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VMY9", "FBgn0261436" ] }, "reaction_10431529": { "compartment": "compartment_70101", "id": "reaction_10431529", "reactome": "R-DME-74247", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29356", "species_29368" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10431526", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "P10351", "FBgn0003308" ] }, "reaction_10466119": { "compartment": "compartment_70101", "id": "reaction_10466119", "reactome": "R-DME-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10466110", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VMW7", "FBgn0031663" ] }, "reaction_10431541": { "compartment": "compartment_70101", "id": "reaction_10431541", "reactome": "R-DME-74249", "name": "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500245" ], "products": [ "species_83956", "species_500244" ], "modifiers": [ [ "species_10431516", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:16750", "CHEBI:28542", "species_112016", "Q9W1K6", "FBgn0034898", "M9PE19", "FBgn0035348" ] }, "reaction_10465661": { "compartment": "compartment_70101", "id": "reaction_10465661", "reactome": "R-DME-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10465656", "catalyst" ] ], "additional_components": [ "FBgn0037911" ] }, "reaction_10465659": { "compartment": "compartment_70101", "id": "reaction_10465659", "reactome": "R-DME-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395880" ], "products": [ "species_29372", "species_2395877" ], "modifiers": [ [ "species_10465656", "catalyst" ] ], "additional_components": [ "FBgn0037911" ] }, "reaction_10465590": { "compartment": "compartment_5460", "id": "reaction_10465590", "reactome": "R-DME-2393954", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2393945", "species_113521" ], "products": [ "species_2393950", "species_159448" ], "modifiers": [ [ "species_10465587", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VV83", "FBgn0036648" ] }, "reaction_10465664": { "compartment": "compartment_70101", "id": "reaction_10465664", "reactome": "R-DME-2395965", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395963", "species_29356" ], "products": [ "species_29372", "species_2395964" ], "modifiers": [ [ "species_10465656", "catalyst" ] ], "additional_components": [ "FBgn0037911" ] }, "reaction_10466116": { "compartment": "compartment_70101", "id": "reaction_10466116", "reactome": "R-DME-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10466110", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VMW7", "FBgn0031663" ] }, "reaction_10433331": { "compartment": "compartment_984", "id": "reaction_10433331", "reactome": "R-DME-109278", "name": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_500101" ], "products": [ "species_500104", "species_109277" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_29602", "species_76577", "species_5696194", "species_109386", "species_83927", "CHEBI:16750", "species_83908", "CHEBI:17256", "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10431539": { "compartment": "compartment_70101", "id": "reaction_10431539", "reactome": "R-DME-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10431536", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "Q9VWV5", "FBgn0052549", "species_29926" ] }, "reaction_10431553": { "compartment": "compartment_70101", "id": "reaction_10431553", "reactome": "R-DME-74258", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_30064" ], "products": [ "species_30034", "species_29408" ], "modifiers": [ [ "species_10431526", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "P10351", "FBgn0003308" ] }, "reaction_10466113": { "compartment": "compartment_70101", "id": "reaction_10466113", "reactome": "R-DME-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10466110", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VMW7", "FBgn0031663" ] }, "reaction_10465084": { "compartment": "compartment_70101", "id": "reaction_10465084", "reactome": "R-DME-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10465081", "catalyst" ] ], "additional_components": [ "P41043", "FBgn0010226", "species_29450" ] }, "reaction_10443627": { "compartment": "compartment_70101", "id": "reaction_10443627", "reactome": "R-DME-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10443624", "catalyst" ] ], "additional_components": [ "Q9VH95", "FBgn0037728", "Q9V420", "FBgn0004465" ] }, "reaction_10465079": { "compartment": "compartment_12045", "id": "reaction_10465079", "reactome": "R-DME-2161660", "name": "PGH2 is isomerised to PGE2 by PTGES", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10465076", "catalyst" ] ], "additional_components": [ "species_29450", "Q8SY19", "FBgn0025814", "Q86B54", "FBgn0053177", "X2JF29", "FBgn0053178" ] }, "reaction_10465060": { "compartment": "compartment_70101", "id": "reaction_10465060", "reactome": "R-DME-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10465057": { "compartment": "compartment_70101", "id": "reaction_10465057", "reactome": "R-DME-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10474576": { "compartment": "compartment_7660", "id": "reaction_10474576", "reactome": "R-DME-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10474566" ], "products": [ "species_5651834", "species_10474568" ], "modifiers": [ [ "species_10474573", "catalyst" ] ], "additional_components": [ "P35875", "FBgn0010247", "P35875", "FBgn0010247", "FBgn0023216" ] }, "reaction_10433082": { "compartment": "compartment_70101", "id": "reaction_10433082", "reactome": "R-DME-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10433079", "catalyst" ] ], "additional_components": [ "X2JEY5", "FBgn0052626" ] }, "reaction_10431497": { "compartment": "compartment_70101", "id": "reaction_10431497", "reactome": "R-DME-74213", "name": "Adenine + PRPP => AMP + PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_83951" ], "products": [ "species_111294", "species_76577" ], "modifiers": [ [ "species_10431494", "catalyst" ] ], "additional_components": [ "P12426", "FBgn0000109" ] }, "reaction_10465047": { "compartment": "compartment_70101", "id": "reaction_10465047", "reactome": "R-DME-2161187", "name": "N6-methyl-AMP + H2O => IMP + methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161190" ], "products": [ "species_2161177", "species_29602" ], "modifiers": [ [ "species_10465044", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VHH7", "FBgn0037661" ] }, "reaction_10433411": { "compartment": "compartment_70101", "id": "reaction_10433411", "reactome": "R-DME-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_500088", "species_29370" ], "modifiers": [ [ "species_10433408", "catalyst" ] ], "additional_components": [ "species_83908", "CHEBI:17256", "species_76577", "species_109386", "Q9VU38", "FBgn0283494", "species_29926" ] }, "reaction_10458882": { "compartment": "compartment_876", "id": "reaction_10458882", "reactome": "R-DME-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458879", "catalyst" ] ], "additional_components": [ "Q9W2L7", "FBgn0085425" ] }, "reaction_10456063": { "compartment": "compartment_70101", "id": "reaction_10456063", "reactome": "R-DME-977348", "name": "PHGHD tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29728" ], "products": [ "species_977329", "species_70106", "species_73473" ], "modifiers": [ [ "species_10456060", "catalyst" ] ], "additional_components": [ "Q9VKI8", "FBgn0032350" ] }, "reaction_10456042": { "compartment": "compartment_70101", "id": "reaction_10456042", "reactome": "R-DME-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10456039", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VSY6", "FBgn0023129" ] }, "reaction_10491958": { "compartment": "compartment_70101", "id": "reaction_10491958", "reactome": "R-DME-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10491947", "catalyst" ] ], "additional_components": [ "FBgn0028399" ] }, "reaction_10456053": { "compartment": "compartment_70101", "id": "reaction_10456053", "reactome": "R-DME-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977329", "species_29404" ], "products": [ "species_29406", "species_936706" ], "modifiers": [ [ "species_10456050", "catalyst" ] ], "additional_components": [ "Q9VAN0", "FBgn0014427" ] }, "reaction_10469871": { "compartment": "compartment_7660", "id": "reaction_10469871", "reactome": "R-DME-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469863" ], "products": [ "species_10467222", "species_10469869" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0002906", "FBgn0010602", "FBgn0002906", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469853": { "compartment": "compartment_7660", "id": "reaction_10469853", "reactome": "R-DME-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10465325" ], "products": [ "species_10467222", "species_10469851" ], "modifiers": [ [ "species_10469560", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010247", "FBgn0010602", "FBgn0010247", "FBgn0003612" ] }, "reaction_10469847": { "compartment": "compartment_7660", "id": "reaction_10469847", "reactome": "R-DME-4551738", "name": "SUMOylation of TDG with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10433855" ], "products": [ "species_10469845", "species_10467222" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0026869", "FBgn0026869", "FBgn0010602", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469893": { "compartment": "compartment_7660", "id": "reaction_10469893", "reactome": "R-DME-4570463", "name": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469883" ], "products": [ "species_10469891", "species_10467222" ], "modifiers": [ [ "species_10467488", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "FBgn0010602", "P26017", "FBgn0003042", "Q9VB08", "FBgn0003330", "Q9VHA0", "FBgn0003334", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "P39769", "FBgn0004861", "Q9VKL0", "FBgn0032330", "Q9W523", "FBgn0004860" ] }, "reaction_10469936": { "compartment": "compartment_7660", "id": "reaction_10469936", "reactome": "R-DME-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469926" ], "products": [ "species_10467222", "species_10469934" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q95RC8", "FBgn0002872", "Q9VUB7", "FBgn0052133", "FBgn0010602", "Q9VUB7", "FBgn0052133", "Q95RC8", "FBgn0002872", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469840": { "compartment": "compartment_7660", "id": "reaction_10469840", "reactome": "R-DME-4551616", "name": "SUMOylation of RPA1 (RPA70) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10427308" ], "products": [ "species_10467222", "species_10469838" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010173", "FBgn0010602", "FBgn0010173", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10435033": { "compartment": "compartment_114521", "id": "reaction_10435033", "reactome": "R-DME-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10435030", "catalyst" ] ], "additional_components": [ "species_114520", "species_74016", "P29993", "FBgn0010051" ] }, "reaction_10473205": { "compartment": "compartment_876", "id": "reaction_10473205", "reactome": "R-DME-5617178", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447516", "species_10447500" ], "products": [ "species_10473203" ], "modifiers": [], "additional_components": [ "FBgn0011676", "FBgn0259214", "Q59DP9", "FBgn0259214", "Q27571", "FBgn0011676" ] }, "reaction_10464851": { "compartment": "compartment_70101", "id": "reaction_10464851", "reactome": "R-DME-2089943", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10464846", "catalyst" ] ], "additional_components": [ "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "P83094", "Stim" ] }, "reaction_10471073": { "compartment": "compartment_12045", "id": "reaction_10471073", "reactome": "R-DME-5226904", "name": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457748", "species_10471069" ], "products": [ "species_10471071" ], "modifiers": [], "additional_components": [ "species_114520", "P29993", "FBgn0010051", "Q9VZX9", "FBgn0035371", "P50245", "FBgn0015011", "species_427523", "Q9VZX9", "FBgn0035371", "P50245", "FBgn0015011", "species_427523", "species_114520", "P29993", "FBgn0010051" ] }, "reaction_10473217": { "compartment": "compartment_70101", "id": "reaction_10473217", "reactome": "R-DME-5617179", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10473210" ], "products": [ "species_29370", "species_10473214" ], "modifiers": [ [ "species_10434289", "catalyst" ], [ "species_10473203", "catalyst" ] ], "additional_components": [ "FBgn0283471", "FBgn0283471", "Q59DP9", "FBgn0259214", "Q27571", "FBgn0011676" ] }, "reaction_10466954": { "compartment": "compartment_70101", "id": "reaction_10466954", "reactome": "R-DME-2730894", "name": "NFKB1:RELA translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10441907": { "compartment": "compartment_70101", "id": "reaction_10441907", "reactome": "R-DME-202328", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112275", "species_10441582" ], "products": [ "species_10441905" ], "modifiers": [], "additional_components": [ "FBgn0259680", "P83099", "FBgn0259680", "species_112275" ] }, "reaction_10472898": { "compartment": "compartment_70101", "id": "reaction_10472898", "reactome": "R-DME-5607724", "name": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472896" ], "products": [ "species_10437411" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q03017", "phospho-cact", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10466833": { "compartment": "compartment_70101", "id": "reaction_10466833", "reactome": "R-DME-2730835", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441891", "species_113592" ], "products": [ "species_29370", "species_10466831" ], "modifiers": [], "additional_components": [ "species_112275", "P83099", "FBgn0259680", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10458269": { "compartment": "compartment_70101", "id": "reaction_10458269", "reactome": "R-DME-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10458266", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VN95", "FBgn0037305" ] }, "reaction_10458249": { "compartment": "compartment_70101", "id": "reaction_10458249", "reactome": "R-DME-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10458246", "catalyst" ] ], "additional_components": [ "FBgn0039849" ] }, "reaction_10458279": { "compartment": "compartment_70101", "id": "reaction_10458279", "reactome": "R-DME-1237160", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_353106" ], "products": [ "species_1237165", "species_83951" ], "modifiers": [ [ "species_10458276", "catalyst" ] ], "additional_components": [ "Q9V813", "FBgn0034215" ] }, "reaction_10458259": { "compartment": "compartment_70101", "id": "reaction_10458259", "reactome": "R-DME-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10458256", "catalyst" ] ], "additional_components": [ "Q6AWN0", "FBgn0052068", "species_111793" ] }, "reaction_10455900": { "compartment": "compartment_20699", "id": "reaction_10455900", "reactome": "R-DME-975919", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_975910" ], "products": [ "species_981618" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10455845": { "compartment": "compartment_20699", "id": "reaction_10455845", "reactome": "R-DME-975903", "name": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981616" ], "modifiers": [ [ "species_10455842", "catalyst" ] ], "additional_components": [ "Q9VUH5", "FBgn0036447", "Q9VUH4", "FBgn0036446" ] }, "reaction_10455826": { "compartment": "compartment_20699", "id": "reaction_10455826", "reactome": "R-DME-975902", "name": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975925", "species_975910" ], "products": [ "species_981615" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "FBgn0035050" ] }, "reaction_10440190": { "compartment": "compartment_984", "id": "reaction_10440190", "reactome": "R-DME-192417", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171076" ], "products": [ "species_171149", "species_174602" ], "modifiers": [ [ "species_10440187", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "Q9W1B3", "FBgn0034972", "Q7KT70", "FBgn0001987", "Q9VIC7", "FBgn0051146" ] }, "reaction_10440195": { "compartment": "compartment_984", "id": "reaction_10440195", "reactome": "R-DME-192430", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10440187", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "Q9W1B3", "FBgn0034972", "Q7KT70", "FBgn0001987", "Q9VIC7", "FBgn0051146" ] }, "reaction_10440193": { "compartment": "compartment_984", "id": "reaction_10440193", "reactome": "R-DME-192425", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6814795" ], "products": [ "species_174602", "species_192438" ], "modifiers": [ [ "species_10440187", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "Q9W1B3", "FBgn0034972", "Q7KT70", "FBgn0001987", "Q9VIC7", "FBgn0051146" ] }, "reaction_10495454": { "compartment": "compartment_984", "id": "reaction_10495454", "reactome": "R-DME-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10495451", "catalyst" ] ], "additional_components": [] }, "reaction_10439518": { "compartment": "compartment_984", "id": "reaction_10439518", "reactome": "R-DME-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10439515", "catalyst" ] ], "additional_components": [ "species_964746", "O18408", "FBgn0020506", "P81641", "FBgn0000078", "P08144", "FBgn0000079" ] }, "reaction_10479867": { "compartment": "compartment_984", "id": "reaction_10479867", "reactome": "R-DME-6786421", "name": "CHIA hydrolyses chitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6786438" ], "products": [ "species_6786426", "species_6786428" ], "modifiers": [ [ "species_10479864", "catalyst" ] ], "additional_components": [ "species_1678743", "FBgn0022702" ] }, "reaction_10439525": { "compartment": "compartment_984", "id": "reaction_10439525", "reactome": "R-DME-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10439522", "catalyst" ] ], "additional_components": [ "Q9VV98", "FBgn0036659" ] }, "reaction_10479907": { "compartment": "compartment_984", "id": "reaction_10479907", "reactome": "R-DME-6786652", "name": "CHIT1 hydrolyses CHIT to 3xADGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6786654" ], "products": [ "species_6786660" ], "modifiers": [ [ "species_10479904", "catalyst" ] ], "additional_components": [ "Q8T0R7", "FBgn0064237", "Q9W303", "FBgn0026415", "Q8MM24", "FBgn0020416", "Q9VZV2", "FBgn0035398", "Q8MLZ7", "FBgn0020414", "Q9V3D4", "FBgn0020415", "Q23997", "FBgn0013763" ] }, "reaction_10439922": { "compartment": "compartment_984", "id": "reaction_10439922", "reactome": "R-DME-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189071" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10439515", "catalyst" ] ], "additional_components": [ "species_964746", "O18408", "FBgn0020506", "P81641", "FBgn0000078", "P08144", "FBgn0000079" ] }, "reaction_10491791": { "compartment": "compartment_984", "id": "reaction_10491791", "reactome": "R-DME-8878787", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8878780" ], "products": [ "species_8878776", "species_109277" ], "modifiers": [ [ "species_10491788", "catalyst" ] ], "additional_components": [ "species_1562550", "species_74016", "Q9VRM9", "FBgn0035620", "Q9VXS8", "FBgn0030661", "Q9W273", "FBgn0034712", "Q9W274", "FBgn0283480", "Q9W275", "FBgn0034710", "M9PD70", "FBgn0283479", "Q24238", "FBgn0016123", "Q7K3X8", "FBgn0033423", "Q9VDG4", "FBgn0038845", "Q9VH28", "FBgn0037786", "Q9VHD0", "FBgn0043791", "Q9VIW9", "FBgn0032779", "Q9VRM8", "FBgn0035619" ] }, "reaction_10477790": { "compartment": "compartment_70101", "id": "reaction_10477790", "reactome": "R-DME-5690827", "name": "TNFAIP3 (A20) ubiquitinates RIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454480", "species_10477782" ], "products": [ "species_10477787" ], "modifiers": [ [ "species_10477782", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734" ] }, "reaction_10477822": { "compartment": "compartment_70101", "id": "reaction_10477822", "reactome": "R-DME-5690870", "name": "OTUD7B,TNFAIP3 deubiquitinate TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477817" ], "products": [ "species_10454480", "species_10477819" ], "modifiers": [ [ "species_10477817", "catalyst" ] ], "additional_components": [ "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VH90", "FBgn0037734", "Q9W3I9", "FBgn0265464", "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734" ] }, "reaction_10479341": { "compartment": "compartment_70101", "id": "reaction_10479341", "reactome": "R-DME-6781953", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479337", "species_10471517" ], "products": [ "species_10479339" ], "modifiers": [], "additional_components": [ "FBgn0035593", "FBgn0286784", "Q7KN62", "FBgn0286784", "Q9VRJ9", "FBgn0035593" ] }, "reaction_10477802": { "compartment": "compartment_70101", "id": "reaction_10477802", "reactome": "R-DME-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477794", "species_10477798" ], "products": [ "species_10477800" ], "modifiers": [], "additional_components": [ "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q8IMZ4", "FBgn0039044", "P48148", "Rho1", "Q9W3I9", "FBgn0265464", "Q06003", "FBgn0004919", "Q8IMZ4", "FBgn0039044", "P48148", "Rho1", "Q9W3I9", "FBgn0265464", "Q9VL00", "FBgn0032214" ] }, "reaction_10479481": { "compartment": "compartment_7660", "id": "reaction_10479481", "reactome": "R-DME-6783238", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479475", "species_10479477" ], "products": [ "species_10479479" ], "modifiers": [], "additional_components": [ "Q9VL00", "FBgn0032214", "Q8WS79", "FBgn0035849", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q8WS79", "FBgn0035849", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VL00", "FBgn0032214" ] }, "reaction_10490409": { "compartment": "compartment_70101", "id": "reaction_10490409", "reactome": "R-DME-8869506", "name": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490406" ], "products": [ "species_10437507", "species_10477819" ], "modifiers": [ [ "species_10490406", "catalyst" ] ], "additional_components": [ "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VH90", "FBgn0037734", "Q9W3I9", "FBgn0265464", "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734" ] }, "reaction_10477810": { "compartment": "compartment_70101", "id": "reaction_10477810", "reactome": "R-DME-5690856", "name": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477807" ], "products": [ "species_10437507", "species_10477782" ], "modifiers": [ [ "species_10477807", "catalyst" ] ], "additional_components": [ "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734" ] }, "reaction_10479330": { "compartment": "compartment_70101", "id": "reaction_10479330", "reactome": "R-DME-6781905", "name": "ZRANB1 binds APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477812", "species_10440558" ], "products": [ "species_10479328" ], "modifiers": [], "additional_components": [ "FBgn0037734", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9VH90", "FBgn0037734" ] }, "reaction_209107": { "compartment": "compartment_70101", "id": "reaction_209107", "reactome": "R-DME-209107", "name": "Further phosphorylation of APC by DCO", "reversible": "false", "notes": "Three Serine residues in APC (APC/APC2) are further phosphorylated by DCO. Ser1504, Ser1507 (priming), and Ser1510 in Human APC are further phosphorylated by CKIepsilon.", "reactants": [ "species_113592", "species_206811" ], "products": [ "species_206735", "species_29370" ], "modifiers": [ [ "species_206811", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P18431", "sgg", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209143": { "compartment": "compartment_70101", "id": "reaction_209143", "reactome": "R-DME-209143", "name": "Phosphorylation of AXN and APC by DCO", "reversible": "false", "notes": "Axin (AXN) and APC (APC/APC2) in the 'destruction complex' are primed for phosphorylation by the CKIepsilon orthologue DCO. Ser1505 in Human APC and Ser531 in Human Axin (equivalent to Ser621 in Mouse and Ser529 in Fly) are phosphorylated.", "reactants": [ "species_113592", "species_206741" ], "products": [ "species_29370", "species_206898" ], "modifiers": [ [ "species_206741", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_209082": { "compartment": "compartment_70101", "id": "reaction_209082", "reactome": "R-DME-209082", "name": "Further phosphorylation of APC by SGG", "reversible": "false", "notes": "A Serine in APC (APC/APC2) is further phosphorylated by Shaggy (SGG). Ser1503 in Human APC is phosphorylated by GSK3beta.", "reactants": [ "species_206735", "species_113592" ], "products": [ "species_29370", "species_206602" ], "modifiers": [ [ "species_206735", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P18431", "sgg", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P18431", "sgg", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209049": { "compartment": "compartment_70101", "id": "reaction_209049", "reactome": "R-DME-209049", "name": "Phosphorylation of AXN and APC by SGG", "reversible": "false", "notes": "Additional phosphorylation of the scaffolding molecules, Axin (AXN) and APC (APC/APC2), is carried out by the GSK3beta kinase orthologue Shaggy (SGG) with Ser1501 (also a priming phosphorylation) in Human APC and Ser614 and Thr609 in Mouse Axin (equivalent to Ser522 and Thr517 respectively in Fly and Ser524 and Thr519 in Human).", "reactants": [ "species_113592", "species_206898" ], "products": [ "species_29370", "species_206811" ], "modifiers": [ [ "species_206898", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209109": { "compartment": "compartment_70101", "id": "reaction_209109", "reactome": "R-DME-209109", "name": "Further phosphorylation of ARM by SGG", "reversible": "false", "notes": "Phosphorylation of bound Armadillo (ARM) at Ser44, Ser48, and Thr52 by Shaggy (SGG) occurs.", "reactants": [ "species_113592", "species_206805" ], "products": [ "species_29370", "species_207028" ], "modifiers": [ [ "species_206805", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209134": { "compartment": "compartment_70101", "id": "reaction_209134", "reactome": "R-DME-209134", "name": "Phosphorylation of ARM by CKIalpha", "reversible": "false", "notes": "Armadillo (ARM) is primed for phosphorylation by CKIalpha at Ser56.", "reactants": [ "species_113592", "species_206666" ], "products": [ "species_29370", "species_206805" ], "modifiers": [ [ "species_206666", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209097": { "compartment": "compartment_70101", "id": "reaction_209097", "reactome": "R-DME-209097", "name": "ARM binds to APC and AXN in the 'destruction complex'", "reversible": "false", "notes": "Phosphorylated APC (APC/APC2) and Axin (AXN) are able to bind cytoplasmic Armadillo (ARM) more strongly. This now brings ARM into the 'destruction complex' and within reach of the complexed kinases.", "reactants": [ "species_205774", "species_206602" ], "products": [ "species_206666" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209133": { "compartment": "compartment_70101", "id": "reaction_209133", "reactome": "R-DME-209133", "name": "Formation of the 'destruction complex'", "reversible": "false", "notes": "The 'destruction complex' is formed from the large scaffolding proteins Axin (AXN) and APC (APC/APC2). This enables regulating molecules such as the kinases, CKIalpha, DCO, and Shaggy (SGG) and the phosphatase, PP2A to be held together in close proximity where they can regulate the phosphorylation of the scaffolding molecules and cytoplasmic Armadillo (ARM). The protein serine/threonine phosphatase PP2A is made up of the regulatory subunit A, PP2A-29B; the regulatory subunit B, Twins (TWS); and the catalytic subunit C, Microtubule star (MTS).", "reactants": [ "species_206938", "species_205716", "species_206581", "species_205729", "species_206017", "species_206210" ], "products": [ "species_206741" ], "modifiers": [], "additional_components": [ "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_10436639": { "compartment": "compartment_7660", "id": "reaction_10436639", "reactome": "R-DME-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10432514" ], "modifiers": [ [ "species_10436628", "catalyst" ] ], "additional_components": [ "Q7KTI0", "FBgn0026718", "Q9VYJ4", "FBgn0030421", "Q9VID4", "FBgn0032940", "Q9VB47", "FBgn0039509" ] }, "reaction_10436637": { "compartment": "compartment_7660", "id": "reaction_10436637", "reactome": "R-DME-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10436635" ], "modifiers": [ [ "species_10436628", "catalyst" ] ], "additional_components": [ "FBgn0033246", "Q9VID4", "FBgn0032940", "Q9VB47", "FBgn0039509" ] }, "reaction_10436630": { "compartment": "compartment_7660", "id": "reaction_10436630", "reactome": "R-DME-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10432485" ], "modifiers": [ [ "species_10436628", "catalyst" ] ], "additional_components": [ "FBgn0283427", "Q9VID4", "FBgn0032940", "Q9VB47", "FBgn0039509" ] }, "reaction_10433767": { "compartment": "compartment_70101", "id": "reaction_10433767", "reactome": "R-DME-109858", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433763", "species_10433742" ], "products": [ "species_10433765" ], "modifiers": [], "additional_components": [ "FBgn0003256", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10433796": { "compartment": "compartment_70101", "id": "reaction_10433796", "reactome": "R-DME-109864", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433789" ], "products": [ "species_10433763", "species_10433787" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "FBgn0003256" ] }, "reaction_10428216": { "compartment": "compartment_70101", "id": "reaction_10428216", "reactome": "R-DME-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29448" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10428192", "catalyst" ] ], "additional_components": [ "A1ZAA5", "FBgn0001124" ] }, "reaction_10444310": { "compartment": "compartment_70101", "id": "reaction_10444310", "reactome": "R-DME-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10444305", "catalyst" ] ], "additional_components": [ "FBgn0028646" ] }, "reaction_10479958": { "compartment": "compartment_70101", "id": "reaction_10479958", "reactome": "R-DME-6787757", "name": "PXLP-K333-GADL1 decarboxylates acidic AAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787759" ], "products": [ "species_113528", "species_6787762" ], "modifiers": [ [ "species_10479955", "catalyst" ] ], "additional_components": [ "species_1614519", "species_113553", "CHEBI:17285", "species_73590", "species_1655445", "CHEBI:15891", "Q9VPH6", "FBgn0036975", "Q24062", "FBgn0000153" ] }, "reaction_10481284": { "compartment": "compartment_70101", "id": "reaction_10481284", "reactome": "R-DME-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29642" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10481281", "catalyst" ] ], "additional_components": [ "FBgn0029689" ] }, "reaction_10428227": { "compartment": "compartment_5460", "id": "reaction_10428227", "reactome": "R-DME-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113587", "species_113552" ], "modifiers": [ [ "species_10428224", "catalyst" ] ], "additional_components": [ "Q8IPY3", "FBgn0001125" ] }, "reaction_10428195": { "compartment": "compartment_70101", "id": "reaction_10428195", "reactome": "R-DME-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_76213" ], "products": [ "species_29406", "species_29448" ], "modifiers": [ [ "species_10428192", "catalyst" ] ], "additional_components": [ "A1ZAA5", "FBgn0001124" ] }, "reaction_10460687": { "compartment": "compartment_70101", "id": "reaction_10460687", "reactome": "R-DME-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_111707", "species_29382", "species_936714" ], "modifiers": [ [ "species_10460681", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460661": { "compartment": "compartment_70101", "id": "reaction_10460661", "reactome": "R-DME-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_174369" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10460658", "catalyst" ] ], "additional_components": [ "species_71185", "Q9VRD9", "FBgn0031148" ] }, "reaction_10498480": { "compartment": "compartment_70101", "id": "reaction_10498480", "reactome": "R-DME-9679028", "name": "JAK3 binds JAK3 inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678772", "species_10453150" ], "products": [ "species_10498478" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop" ] }, "reaction_10480006": { "compartment": "compartment_70101", "id": "reaction_10480006", "reactome": "R-DME-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480000" ], "products": [ "species_10480004" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10479859": { "compartment": "compartment_70101", "id": "reaction_10479859", "reactome": "R-DME-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479790" ], "products": [ "species_10479857" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10480307": { "compartment": "compartment_17957", "id": "reaction_10480307", "reactome": "R-DME-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10480305" ], "modifiers": [ [ "species_10457732", "catalyst" ] ], "additional_components": [ "FBgn0039562", "Q24151", "Stat92E" ] }, "reaction_10480002": { "compartment": "compartment_70101", "id": "reaction_10480002", "reactome": "R-DME-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479786" ], "products": [ "species_10480000" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10479792": { "compartment": "compartment_70101", "id": "reaction_10479792", "reactome": "R-DME-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718" ], "products": [ "species_10479790" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10498451": { "compartment": "compartment_7660", "id": "reaction_10498451", "reactome": "R-DME-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498447", "species_10436122" ], "products": [ "species_10498449" ], "modifiers": [], "additional_components": [ "FBgn0037482", "FBgn0259937", "O44081", "FBgn0259937", "Q9VI74", "FBgn0037482" ] }, "reaction_169827": { "compartment": "compartment_70101", "id": "reaction_169827", "reactome": "R-DME-169827", "name": "DPDK1 phosphorylates and activates DS6K", "reversible": "false", "notes": "DPDK1 is thought to directly phosphorylate a Threonine residue in the activation loop of the p70 DS6K catalytic domain.", "reactants": [ "species_113592", "species_110503" ], "products": [ "species_29370", "species_110505" ], "modifiers": [ [ "species_110528", "catalyst" ] ], "additional_components": [] }, "reaction_110498": { "compartment": "compartment_70101", "id": "reaction_110498", "reactome": "R-DME-110498", "name": "DTOR is positively regulated by DRheb-GTP", "reversible": "false", "notes": "Insulin signaling stimulates cell growth through the conserved protein kinase DTOR (target of rapamycin). DTOR is positively regulated by DRheb-GTP by a mechanism which has yet to be deciphered although a serine residue is thought to be phosphorylated on DTOR.", "reactants": [ "species_110495", "species_113592" ], "products": [ "species_29370", "species_110497" ], "modifiers": [], "additional_components": [] }, "reaction_110485": { "compartment": "compartment_70101", "id": "reaction_110485", "reactome": "R-DME-110485", "name": "DTSC1 AND DTSC2 form a complex", "reversible": "false", "notes": "Tuberous sclerosis is a human disease caused by mutated TSC1 or TSC2 tumor repressor genes. The Drosophila equivalents form a complex and are negative regulators of TOR signaling.", "reactants": [ "species_110482", "species_110480" ], "products": [ "species_110484" ], "modifiers": [], "additional_components": [ "Q9U9A9", "TSC1", "Q9U9B0", "Phospho-DTSC2" ] }, "reaction_165127": { "compartment": "compartment_70101", "id": "reaction_165127", "reactome": "R-DME-165127", "name": "GEF binds to the inactive DRheb", "reversible": "false", "notes": "The interaction of DRheb with its guanine nucleotide exchange factor (GEF) has not been studied experimentally, but is inferred here by analogy to the very well-studied interaction of Ran GTPase with RCC1 (Azuma et al. 1999; Renault et al. 2001). GEF binds reversibly to the DRheb-GDP complex, forming a GEF:GTPase:GDP complex. Complex formation induces a change in the shape of the GTPase, substantially reducing its affinity for bound guanine nucleotide.", "reactants": [ "species_165124", "species_110416" ], "products": [ "species_165123" ], "modifiers": [], "additional_components": [ "species_29420", "Q9VND8", "Rheb", "Q95V18", "GEF", "species_29420", "Q9VND8", "Rheb" ] }, "reaction_169828": { "compartment": "compartment_70101", "id": "reaction_169828", "reactome": "R-DME-169828", "name": "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex", "reversible": "false", "notes": "DTSC2 is inactivated by DAkt1-dependent phosphorylation of residues threonine (1518) and serine (924) which is thought to destabilize DTSC2 and disrupt it's interaction with DTSC1.", "reactants": [ "species_113592", "species_110484" ], "products": [ "species_29370", "species_110480", "species_169826" ], "modifiers": [ [ "species_110466", "catalyst" ] ], "additional_components": [ "Q9U9A9", "TSC1", "Q9U9B0", "Phospho-DTSC2" ] }, "reaction_110518": { "compartment": "compartment_70101", "id": "reaction_110518", "reactome": "R-DME-110518", "name": "Activated DTOR also phosphorylates D4EBP", "reversible": "false", "notes": "DeIF4E is an initiation factor for eukaryotic translation. D4EBP forms a complex with DeIF4E, inactivating the latter. Activated DTOR phosphorylates D4EBP on a threonine residue, causing it to dissociate from DeIF4E.", "reactants": [ "species_113592", "species_110512" ], "products": [ "species_110511", "species_29370", "species_110517" ], "modifiers": [ [ "species_110497", "catalyst" ] ], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1" ] }, "reaction_165131": { "compartment": "compartment_70101", "id": "reaction_165131", "reactome": "R-DME-165131", "name": "GEF dissociates from DRheb-GTP", "reversible": "false", "notes": "The interaction of DRheb with its guanine nucleotide exchange factor (GEF) has not been studied experimentally, but is inferred here by analogy to the very well-studied interaction of Ran GTPase with RCC1 (Azuma et al. 1999; Renault et al. 2001). The GEF:DRheb-GTP complex dissociates reversibly to GEF + DRheb-GTP. The affinity of GTPase for bound nucleotide returns to its high value, so the nucleotide now stays strongly bound.", "reactants": [ "species_165125" ], "products": [ "species_110415", "species_165124" ], "modifiers": [], "additional_components": [ "Q95V18", "GEF", "species_29438", "Q9VND8", "Rheb", "species_29438", "Q9VND8", "Rheb" ] }, "reaction_110491": { "compartment": "compartment_70101", "id": "reaction_110491", "reactome": "R-DME-110491", "name": "DRheb is inhibited by the TSC1/2 complex", "reversible": "false", "notes": "The DTSC1/2 complex antagonizes the amino-acid-TOR signaling pathway. DTSC1/2 complex has a GTPase-activating protein domain (GAP). DRheb (a small GTPase called Ras homologue enriched in brain) is a target for DTSC2 GAP activity. As DRheb is a downstream effector from DTSC1/2, its inhibition by DTSC1/2 results in growth inhibition.", "reactants": [ "species_110415" ], "products": [ "species_29372", "species_110416" ], "modifiers": [ [ "species_110484", "catalyst" ] ], "additional_components": [ "species_29438", "Q9VND8", "Rheb", "species_29420", "Q9VND8", "Rheb", "Q9U9A9", "TSC1", "Q9U9B0", "Phospho-DTSC2" ] }, "reaction_165129": { "compartment": "compartment_70101", "id": "reaction_165129", "reactome": "R-DME-165129", "name": "GDP is exchanged for GTP on DRheb", "reversible": "false", "notes": "The GEF:DRheb-GDP complex freely exchanges its bound nucleotide for free nucleotide from the cytosol. Normally, the concentration of cytosolic GTP is about ten times greater than the concentration of GDP, so under physiological conditions, this exchange event favors formation of DRheb-GTP.", "reactants": [ "species_29438", "species_165123" ], "products": [ "species_29420", "species_165125" ], "modifiers": [ [ "species_165123", "catalyst" ] ], "additional_components": [ "Q95V18", "GEF", "species_29420", "Q9VND8", "Rheb", "Q95V18", "GEF", "species_29438", "Q9VND8", "Rheb", "Q95V18", "GEF", "species_29420", "Q9VND8", "Rheb" ] }, "reaction_110506": { "compartment": "compartment_70101", "id": "reaction_110506", "reactome": "R-DME-110506", "name": "Activated DTOR phosphorylates DS6K", "reversible": "false", "notes": "DTOR phosphorylates a threonine residue on DS6K, which is an important effector of cell growth.", "reactants": [ "species_113592", "species_110503" ], "products": [ "species_29370", "species_110505" ], "modifiers": [ [ "species_110497", "catalyst" ] ], "additional_components": [] }, "reaction_110437": { "compartment": "compartment_984", "id": "reaction_110437", "reactome": "R-DME-110437", "name": "DILP binds to Drosophila insulin receptor (DINR)", "reversible": "false", "notes": "Drosophila contains seven insulin-like genes which encode for DILP (Drosophila Insulin-like peptide)1-7. These DILPs can bind to the Drosophila Insulin receptor (DINR) to initiate intracellular signaling.", "reactants": [ "species_110422", "species_164721" ], "products": [ "species_110427" ], "modifiers": [], "additional_components": [ "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR" ] }, "reaction_110453": { "compartment": "compartment_70101", "id": "reaction_110453", "reactome": "R-DME-110453", "name": "Phosphorylation of PIP2 to PIP3 by Dp110", "reversible": "false", "notes": "PI3Ks are implicated in cell growth, number and size. Dp110, the Drosophila PI3K, phosphorylates PIP2 -> PIP3 (both intracellular messengers) to continue the signaling mechanism. Overexpression of Dp110 results in enlarged cell size and number suggesting a role for Dp110 in growth and size control.", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_38117" ], "modifiers": [ [ "species_110435", "catalyst" ] ], "additional_components": [ "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "O18683", "PI3K21B", "P91634", "Pi3K92E" ] }, "reaction_110468": { "compartment": "compartment_70101", "id": "reaction_110468", "reactome": "R-DME-110468", "name": "Activation of DAkt1 by DPDK1", "reversible": "false", "notes": "DPDK1 (a phosphoinositide-dependant protein kinase) controls cellular and organism growth through two effector pathways by activating DAkt and DS6K (S6 kinase). Phosphorylation of the residues Thr308 and Ser473 by DPDK1 (and another downstream kinase?) relieves intermolecular inhibition, allowing the activated DAkt to dissociate from PIP3 and modify its target, DFOXO.", "reactants": [ "species_113592", "species_110452" ], "products": [ "species_29370", "species_38117", "species_110466" ], "modifiers": [ [ "species_110528", "catalyst" ] ], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_110440": { "compartment": "compartment_70101", "id": "reaction_110440", "reactome": "R-DME-110440", "name": "Autophosphorylation of DINR", "reversible": "false", "notes": "Binding of a DILP to DINR induces a conformational change leading to autophosphorylation.", "reactants": [ "species_110427", "species_113592" ], "products": [ "species_110426", "species_29370" ], "modifiers": [ [ "species_110427", "catalyst" ] ], "additional_components": [ "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR" ] }, "reaction_164696": { "compartment": "compartment_70101", "id": "reaction_164696", "reactome": "R-DME-164696", "name": "Chico is phosphorylated", "reversible": "false", "notes": "The beta subunit of the DINR complex binds and phosphorylates Chico. Chico has 3 phosphotyrosine binding domains on residues 411, 911 and 948 where it can be phosphorylated. The tyrosine kinase function of DINR phosphorylates Chico on these domains. Phosphorylated Chico binds to SH2 domain-containing proteins such as PI3K (Phosphoinositide 3-Kinase).", "reactants": [ "species_110430", "species_113592" ], "products": [ "species_29370", "species_164707" ], "modifiers": [ [ "species_110430", "catalyst" ] ], "additional_components": [ "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico", "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico" ] }, "reaction_110459": { "compartment": "compartment_70101", "id": "reaction_110459", "reactome": "R-DME-110459", "name": "PIP3 dephosphorylated to PIP2 by DPTEN", "reversible": "false", "notes": "DPTEN (a phosphoinositide phosphatase) catalyses the reversal of PIP3 to PIP2. This mechanism, together with Dp110 activity, regulates the levels of PIP3 which is the second messenger for controlling organism size.", "reactants": [ "species_38117" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_110456", "catalyst" ] ], "additional_components": [] }, "reaction_110475": { "compartment": "compartment_70101", "id": "reaction_110475", "reactome": "R-DME-110475", "name": "DAkt1-mediated phosphorylation inactivates DFOXO", "reversible": "false", "notes": "DFOXO belongs to the FOXO subfamily of forkhead transcription factors. The FOXO factors regulate genes involved in cell cycle control, cell death and stress responses. Phosphorylation of DFOXO by DAkt1 on three residues (Thr44, Ser190 and Ser259) leads to its cytoplasmic retention and inactivation, inhibiting expression of DFOXO-regulated genes. These include D4EBP, DInR and Chico.", "reactants": [ "species_113592", "species_110472" ], "products": [ "species_110474", "species_29370" ], "modifiers": [ [ "species_110466", "catalyst" ] ], "additional_components": [] }, "reaction_110442": { "compartment": "compartment_70101", "id": "reaction_110442", "reactome": "R-DME-110442", "name": "Activated DINR binds Chico", "reversible": "false", "notes": "The Drosophila homologue to mammalian IRS1-4 (Insulin Receptor Substrate), Chico, binds to the beta subunit of DINR. Chico is an adaptor protein that interacts with the activated drosophila insulin-like receptor (DINR), allowing signaling molecules to attach and signal to downstream effectors.", "reactants": [ "species_110429", "species_110426" ], "products": [ "species_110430" ], "modifiers": [], "additional_components": [ "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico" ] }, "reaction_110463": { "compartment": "compartment_70101", "id": "reaction_110463", "reactome": "R-DME-110463", "name": "Increased PIP3 levels recruit DAkt1 to the membrane", "reversible": "false", "notes": "DAkt (a protein kinase B) is recruited to the plasma membrane due to the interaction between its PH (pleckstrin homology) domain and PIP3. In Drosophila, DAkt appears to be the only target activated by increased PIP3 levels.", "reactants": [ "species_110462", "species_38117" ], "products": [ "species_110452" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_110446": { "compartment": "compartment_70101", "id": "reaction_110446", "reactome": "R-DME-110446", "name": "Phospho-Chico: Activated DINR binds p60:Dp110", "reversible": "false", "notes": "The Phospho-Chico: Activated DINR in the plasma membrane binds to cytosolic p60:p110. The p60 subunit of the latter complex mediates this interaction; the p110 subunit is the Drosophila PI3K. This complex is an active protein kinase whose direct and indirect targets include PIP2, annotated here.", "reactants": [ "species_110434", "species_164707" ], "products": [ "species_110435" ], "modifiers": [], "additional_components": [ "O18683", "PI3K21B", "P91634", "Pi3K92E", "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "O18683", "PI3K21B", "P91634", "Pi3K92E" ] }, "reaction_10461117": { "compartment": "compartment_172574", "id": "reaction_10461117", "reactome": "R-DME-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_1806198", "species_29370" ], "modifiers": [ [ "species_10461070", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099", "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10461137": { "compartment": "compartment_172574", "id": "reaction_10461137", "reactome": "R-DME-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10461006", "catalyst" ] ], "additional_components": [ "Q8MLR7", "FBgn0028497", "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10461009": { "compartment": "compartment_172574", "id": "reaction_10461009", "reactome": "R-DME-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10461006", "catalyst" ] ], "additional_components": [ "Q8MLR7", "FBgn0028497", "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10445980": { "compartment": "compartment_12045", "id": "reaction_10445980", "reactome": "R-DME-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445976" ], "products": [ "species_10445962" ], "modifiers": [], "additional_components": [ "FBgn0033010", "FBgn0033010" ] }, "reaction_10445916": { "compartment": "compartment_70101", "id": "reaction_10445916", "reactome": "R-DME-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445912" ], "products": [ "species_10445914" ], "modifiers": [], "additional_components": [ "FBgn0033010", "FBgn0033010" ] }, "reaction_10447719": { "compartment": "compartment_20699", "id": "reaction_10447719", "reactome": "R-DME-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445964" ], "products": [ "species_10445912", "species_10447711" ], "modifiers": [ [ "species_10447716", "catalyst" ] ], "additional_components": [ "FBgn0033010", "FBgn0033010", "FBgn0033010", "FBgn0033656" ] }, "reaction_10445974": { "compartment": "compartment_20699", "id": "reaction_10445974", "reactome": "R-DME-381135", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445962" ], "products": [ "species_10445964", "species_10445966" ], "modifiers": [ [ "species_10445971", "catalyst" ] ], "additional_components": [ "FBgn0033010", "FBgn0033010", "FBgn0033010", "FBgn0037105" ] }, "reaction_209303": { "compartment": "compartment_13231", "id": "reaction_209303", "reactome": "R-DME-209303", "name": "LGS transports from the nucleus to the cytosol", "reversible": "false", "notes": "The free Legless (LGS) protein exports from the nucleus to the cytoplasm by an unknown mechanism potentially with additional interaction partners, where it can now target Armadillo (ARM), which is now not being rapidly removed from the cytoplasm by the 'destruction complex'.", "reactants": [ "species_205826" ], "products": [ "species_205724" ], "modifiers": [], "additional_components": [] }, "reaction_209332": { "compartment": "compartment_7660", "id": "reaction_209332", "reactome": "R-DME-209332", "name": "LGS dissociates from the PYGO complex", "reversible": "false", "notes": "The inactivation and destabilisation of the 'destruction complex' means elevated levels of cytoplasmic Armadillo (ARM). In the nucleus, the protein Legless (LGS) dissociates from its nuclear anchor, Pygopus (PYGO).", "reactants": [ "species_206853" ], "products": [ "species_205990", "species_205826" ], "modifiers": [], "additional_components": [ "Q961D9", "LGS", "Q9V9W8", "PYGO" ] }, "reaction_209371": { "compartment": "compartment_70101", "id": "reaction_209371", "reactome": "R-DME-209371", "name": "LGS binds to ARM", "reversible": "false", "notes": "The targeted free cytoplasmic Armadillo (ARM) is complexed to Legless (LGS).", "reactants": [ "species_205724", "species_205774" ], "products": [ "species_206796" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q961D9", "LGS" ] }, "reaction_209177": { "compartment": "compartment_13231", "id": "reaction_209177", "reactome": "R-DME-209177", "name": "LGS:ARM complex transports from the cytosol to the nucleus", "reversible": "false", "notes": "The Legless:Armadillo (LGS:ARM) complex is imported to the nucleus by an unknown mechanism which may include additional interaction partners.", "reactants": [ "species_206796" ], "products": [ "species_206839" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q961D9", "LGS", "Q961D9", "LGS", "P18824", "arm" ] }, "reaction_10461167": { "compartment": "compartment_12045", "id": "reaction_10461167", "reactome": "R-DME-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806234" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10461164", "catalyst" ] ], "additional_components": [ "FBgn0283500" ] }, "reaction_10461022": { "compartment": "compartment_12045", "id": "reaction_10461022", "reactome": "R-DME-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10461019", "catalyst" ] ], "additional_components": [ "M9PDM4", "FBgn0267350", "Q9VND3", "FBgn0037339" ] }, "reaction_10486803": { "compartment": "compartment_70101", "id": "reaction_10486803", "reactome": "R-DME-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486799", "species_10460994" ], "products": [ "species_10486801" ], "modifiers": [], "additional_components": [ "FBgn0025802", "FBgn0025742", "Q9VMI9", "FBgn0025742", "Q9VGH9", "FBgn0025802" ] }, "reaction_10486806": { "compartment": "compartment_70101", "id": "reaction_10486806", "reactome": "R-DME-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10486801", "catalyst" ] ], "additional_components": [ "Q9VMI9", "FBgn0025742", "Q9VGH9", "FBgn0025802" ] }, "reaction_10486809": { "compartment": "compartment_70101", "id": "reaction_10486809", "reactome": "R-DME-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10486801", "catalyst" ] ], "additional_components": [ "Q9VMI9", "FBgn0025742", "Q9VGH9", "FBgn0025802" ] }, "reaction_10486896": { "compartment": "compartment_172574", "id": "reaction_10486896", "reactome": "R-DME-6810392", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486892" ], "products": [ "species_10486894" ], "modifiers": [], "additional_components": [ "FBgn0036058", "FBgn0036058" ] }, "reaction_10486899": { "compartment": "compartment_7660", "id": "reaction_10486899", "reactome": "R-DME-6810410", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_6810412" ], "products": [ "species_6810408", "species_113550" ], "modifiers": [ [ "species_10486894", "catalyst" ] ], "additional_components": [ "FBgn0036058" ] }, "reaction_10487163": { "compartment": "compartment_7660", "id": "reaction_10487163", "reactome": "R-DME-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_29358" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10487160", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924" ] }, "reaction_10461051": { "compartment": "compartment_20699", "id": "reaction_10461051", "reactome": "R-DME-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10461048", "catalyst" ] ], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "A0A4D6K881", "FBgn0004373" ] }, "reaction_10461210": { "compartment": "compartment_20699", "id": "reaction_10461210", "reactome": "R-DME-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10461207", "catalyst" ] ], "additional_components": [ "M9PDM4", "FBgn0267350", "Q9VND3", "FBgn0037339" ] }, "reaction_10461162": { "compartment": "compartment_20699", "id": "reaction_10461162", "reactome": "R-DME-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806159" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10461159", "catalyst" ] ], "additional_components": [ "FBgn0283500" ] }, "reaction_10461094": { "compartment": "compartment_20699", "id": "reaction_10461094", "reactome": "R-DME-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10461070", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099", "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10461062": { "compartment": "compartment_20699", "id": "reaction_10461062", "reactome": "R-DME-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10461059", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926" ] }, "reaction_10461188": { "compartment": "compartment_20699", "id": "reaction_10461188", "reactome": "R-DME-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461186", "species_10461046" ], "products": [ "species_10461048" ], "modifiers": [], "additional_components": [ "FBgn0004373", "P61209", "FBgn0010348", "species_29438", "P61209", "FBgn0010348", "species_29438", "A0A4D6K881", "FBgn0004373" ] }, "reaction_10461027": { "compartment": "compartment_20699", "id": "reaction_10461027", "reactome": "R-DME-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10461024", "catalyst" ] ], "additional_components": [ "FBgn0023508" ] }, "reaction_10461170": { "compartment": "compartment_20699", "id": "reaction_10461170", "reactome": "R-DME-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10461159", "catalyst" ] ], "additional_components": [ "FBgn0283500" ] }, "reaction_10490964": { "compartment": "compartment_437051", "id": "reaction_10490964", "reactome": "R-DME-8874470", "name": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8874484" ], "products": [ "species_8874460" ], "modifiers": [ [ "species_10490961", "catalyst" ] ], "additional_components": [ "species_179838", "species_179856", "species_179856", "species_179838", "Q7KVH9", "FBgn0034894" ] }, "reaction_10461198": { "compartment": "compartment_171062", "id": "reaction_10461198", "reactome": "R-DME-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806238" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10486787": { "compartment": "compartment_70101", "id": "reaction_10486787", "reactome": "R-DME-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486783", "species_10460992" ], "products": [ "species_10486785" ], "modifiers": [], "additional_components": [ "FBgn0030582", "FBgn0025742", "Q9VMI9", "FBgn0025742", "Q9VY15", "FBgn0030582" ] }, "reaction_10461145": { "compartment": "compartment_171062", "id": "reaction_10461145", "reactome": "R-DME-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10461142", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10461176": { "compartment": "compartment_171062", "id": "reaction_10461176", "reactome": "R-DME-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10461142", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10486791": { "compartment": "compartment_70101", "id": "reaction_10486791", "reactome": "R-DME-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486783", "species_10460994" ], "products": [ "species_10486789" ], "modifiers": [], "additional_components": [ "FBgn0030582", "FBgn0025742", "Q9VMI9", "FBgn0025742", "Q9VY15", "FBgn0030582" ] }, "reaction_10461096": { "compartment": "compartment_171062", "id": "reaction_10461096", "reactome": "R-DME-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_1806180", "species_29370" ], "modifiers": [ [ "species_10460982", "catalyst" ] ], "additional_components": [ "FBgn0037339" ] }, "reaction_10488313": { "compartment": "compartment_70101", "id": "reaction_10488313", "reactome": "R-DME-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_29372", "species_8849958" ], "modifiers": [ [ "species_10488310", "catalyst" ] ], "additional_components": [ "species_179838", "species_202247", "species_179856", "species_1806198", "species_1806289", "species_1806212", "FBgn0038890" ] }, "reaction_10486794": { "compartment": "compartment_171062", "id": "reaction_10486794", "reactome": "R-DME-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10486785", "catalyst" ] ], "additional_components": [ "Q9VMI9", "FBgn0025742", "Q9VY15", "FBgn0030582" ] }, "reaction_10461073": { "compartment": "compartment_171062", "id": "reaction_10461073", "reactome": "R-DME-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10461070", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099", "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10461216": { "compartment": "compartment_171062", "id": "reaction_10461216", "reactome": "R-DME-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_29370", "species_1806238" ], "modifiers": [ [ "species_10461055", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926" ] }, "reaction_10487317": { "compartment": "compartment_12045", "id": "reaction_10487317", "reactome": "R-DME-6814254", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6814253" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10487314", "catalyst" ] ], "additional_components": [ "FBgn0003656" ] }, "reaction_10487177": { "compartment": "compartment_876", "id": "reaction_10487177", "reactome": "R-DME-6813740", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6813734" ], "products": [ "species_426910", "species_76114" ], "modifiers": [ [ "species_10487174", "catalyst" ] ], "additional_components": [ "FBgn0038432" ] }, "reaction_10441150": { "compartment": "compartment_70101", "id": "reaction_10441150", "reactome": "R-DME-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10441147", "catalyst" ] ], "additional_components": [] }, "reaction_10461181": { "compartment": "compartment_876", "id": "reaction_10461181", "reactome": "R-DME-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10461178", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924", "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461213": { "compartment": "compartment_876", "id": "reaction_10461213", "reactome": "R-DME-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10461112", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q5U0V7", "FBgn0034691", "A1ZAS8", "FBgn0027506", "Q8MLR7", "FBgn0028497", "Q9VMI9", "FBgn0025742" ] }, "reaction_10461115": { "compartment": "compartment_876", "id": "reaction_10461115", "reactome": "R-DME-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10461112", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q5U0V7", "FBgn0034691", "A1ZAS8", "FBgn0027506", "Q8MLR7", "FBgn0028497", "Q9VMI9", "FBgn0025742" ] }, "reaction_10460987": { "compartment": "compartment_876", "id": "reaction_10460987", "reactome": "R-DME-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10460982", "catalyst" ] ], "additional_components": [ "FBgn0037339" ] }, "reaction_10460951": { "compartment": "compartment_876", "id": "reaction_10460951", "reactome": "R-DME-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461205": { "compartment": "compartment_876", "id": "reaction_10461205", "reactome": "R-DME-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10461202", "catalyst" ] ], "additional_components": [ "Q5U0V7", "FBgn0034691", "M9PHS8", "FBgn0030761", "Q7K161", "FBgn0034179" ] }, "reaction_10461173": { "compartment": "compartment_876", "id": "reaction_10461173", "reactome": "R-DME-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_1806224", "species_29370" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461140": { "compartment": "compartment_876", "id": "reaction_10461140", "reactome": "R-DME-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461012": { "compartment": "compartment_876", "id": "reaction_10461012", "reactome": "R-DME-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_1806240", "species_29370" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10486766": { "compartment": "compartment_70101", "id": "reaction_10486766", "reactome": "R-DME-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486762", "species_10486757" ], "products": [ "species_10486764" ], "modifiers": [], "additional_components": [ "FBgn0035945", "FBgn0028497", "Q8MLR7", "FBgn0028497", "Q8SZY7", "FBgn0035945" ] }, "reaction_10460977": { "compartment": "compartment_876", "id": "reaction_10460977", "reactome": "R-DME-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10460974", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924" ] }, "reaction_10461200": { "compartment": "compartment_876", "id": "reaction_10461200", "reactome": "R-DME-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10461039": { "compartment": "compartment_876", "id": "reaction_10461039", "reactome": "R-DME-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10461036", "catalyst" ] ], "additional_components": [ "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10461134": { "compartment": "compartment_876", "id": "reaction_10461134", "reactome": "R-DME-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10461131", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10486770": { "compartment": "compartment_70101", "id": "reaction_10486770", "reactome": "R-DME-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461105", "species_10486762" ], "products": [ "species_10486768" ], "modifiers": [], "additional_components": [ "FBgn0028497", "FBgn0035945", "Q8SZY7", "FBgn0035945", "Q8MLR7", "FBgn0028497" ] }, "reaction_10461099": { "compartment": "compartment_876", "id": "reaction_10461099", "reactome": "R-DME-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10461036", "catalyst" ] ], "additional_components": [ "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10490903": { "compartment": "compartment_20699", "id": "reaction_10490903", "reactome": "R-DME-8870499", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444044", "species_10490899", "species_1806217" ], "products": [ "species_10490901" ], "modifiers": [], "additional_components": [ "FBgn0010348", "FBgn0030641", "species_392417", "Q9VXV1", "FBgn0030641", "P61209", "FBgn0010348" ] }, "reaction_10486775": { "compartment": "compartment_876", "id": "reaction_10486775", "reactome": "R-DME-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10486772", "catalyst" ] ], "additional_components": [ "Q8SZY7", "FBgn0035945", "Q8MLR7", "FBgn0028497" ] }, "reaction_10486778": { "compartment": "compartment_876", "id": "reaction_10486778", "reactome": "R-DME-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10486772", "catalyst" ] ], "additional_components": [ "Q8SZY7", "FBgn0035945", "Q8MLR7", "FBgn0028497" ] }, "reaction_10461092": { "compartment": "compartment_876", "id": "reaction_10461092", "reactome": "R-DME-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_202247" ], "modifiers": [ [ "species_10461089", "catalyst" ] ], "additional_components": [ "M9PHS8", "FBgn0030761", "Q7K161", "FBgn0034179" ] }, "reaction_10461154": { "compartment": "compartment_876", "id": "reaction_10461154", "reactome": "R-DME-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10461151", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099" ] }, "reaction_10461184": { "compartment": "compartment_876", "id": "reaction_10461184", "reactome": "R-DME-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10441147", "catalyst" ] ], "additional_components": [] }, "reaction_10446383": { "compartment": "compartment_876", "id": "reaction_10446383", "reactome": "R-DME-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592" ], "products": [ "species_29372", "species_29370", "species_425425" ], "modifiers": [ [ "species_10446380", "catalyst" ] ], "additional_components": [ "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793" ] }, "reaction_10471103": { "compartment": "compartment_70101", "id": "reaction_10471103", "reactome": "R-DME-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430457", "species_10471099" ], "products": [ "species_10471101" ], "modifiers": [], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "FBgn0030321", "Q9VYW4", "FBgn0030321", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926" ] }, "reaction_10487844": { "compartment": "compartment_70101", "id": "reaction_10487844", "reactome": "R-DME-8848053", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_8848047" ], "products": [ "species_29372", "species_176478", "species_29370" ], "modifiers": [ [ "species_10487841", "catalyst" ] ], "additional_components": [ "FBgn0263747" ] }, "reaction_10446297": { "compartment": "compartment_17947", "id": "reaction_10446297", "reactome": "R-DME-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10446294", "catalyst" ] ], "additional_components": [ "Q7JUN3", "FBgn0039890", "Q9VWC8", "FBgn0031069" ] }, "reaction_10446328": { "compartment": "compartment_17947", "id": "reaction_10446328", "reactome": "R-DME-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446326", "species_10446302" ], "products": [ "species_10446324", "species_10446294", "species_10446302" ], "modifiers": [], "additional_components": [ "Q9VWC8", "FBgn0031069", "Q7JUN3", "FBgn0039890", "Q8IP97", "FBgn0032407", "FBgn0036484", "FBgn0032407", "Q7JUN3", "FBgn0039890", "Q9VWC8", "FBgn0031069", "FBgn0036484" ] }, "reaction_10459304": { "compartment": "compartment_70101", "id": "reaction_10459304", "reactome": "R-DME-1454928", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_29356", "species_113592" ], "products": [ "species_171149", "species_29372", "species_29370" ], "modifiers": [ [ "species_10459301", "catalyst" ] ], "additional_components": [ "Q9VQY4", "FBgn0020762" ] }, "reaction_10443719": { "compartment": "compartment_876", "id": "reaction_10443719", "reactome": "R-DME-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265784", "species_113592" ], "products": [ "species_29372", "species_29370", "species_265781" ], "modifiers": [ [ "species_10443716", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_8848047", "CHEBI:26125", "species_8848047", "P45843", "FBgn0003515", "P12428", "FBgn0000241", "Q0KI14", "FBgn0051121", "Q8MRJ2", "FBgn0039244" ] }, "reaction_10443895": { "compartment": "compartment_876", "id": "reaction_10443895", "reactome": "R-DME-266082", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_216762", "species_113592" ], "products": [ "species_29372", "species_29370", "species_171095" ], "modifiers": [ [ "species_10443892", "catalyst" ] ], "additional_components": [ "Q0E8U2", "FBgn0031515", "Q8T9E6", "FBgn0264494", "Q9VQY4", "FBgn0020762", "M9PBX3", "FBgn0031449", "Q8MRL3", "FBgn0031516", "Q9VPJ7", "FBgn0031220", "Q8IPV3", "FBgn0025683", "Q9VL61", "FBgn0032167", "Q9VTL3", "FBgn0052091" ] }, "reaction_10476387": { "compartment": "compartment_2133233", "id": "reaction_10476387", "reactome": "R-DME-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5684863" ], "products": [ "species_29372", "species_29370", "species_5684869" ], "modifiers": [ [ "species_10476384", "catalyst" ] ], "additional_components": [ "species_429802", "species_8954401", "species_429802", "species_8954401", "FBgn0031170" ] }, "reaction_10459119": { "compartment": "compartment_17906", "id": "reaction_10459119", "reactome": "R-DME-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10459116", "catalyst" ] ], "additional_components": [ "Q9VF20", "FBgn0038376" ] }, "reaction_10446272": { "compartment": "compartment_70616", "id": "reaction_10446272", "reactome": "R-DME-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_189444", "species_113521" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10446269", "catalyst" ] ], "additional_components": [ "Q9W0C5", "FBgn0035244" ] }, "reaction_10476235": { "compartment": "compartment_70101", "id": "reaction_10476235", "reactome": "R-DME-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_352022" ], "products": [ "species_188972", "species_29372", "species_29370" ], "modifiers": [ [ "species_10446380", "catalyst" ] ], "additional_components": [ "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793" ] }, "reaction_10471050": { "compartment": "compartment_70101", "id": "reaction_10471050", "reactome": "R-DME-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5223341" ], "products": [ "species_5223344", "species_29372", "species_29370" ], "modifiers": [ [ "species_10471047", "catalyst" ] ], "additional_components": [ "Q5BI62", "FBgn0010241" ] }, "reaction_10490055": { "compartment": "compartment_876", "id": "reaction_10490055", "reactome": "R-DME-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489992" ], "products": [ "species_10446380" ], "modifiers": [], "additional_components": [ "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793" ] }, "reaction_10459319": { "compartment": "compartment_876", "id": "reaction_10459319", "reactome": "R-DME-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1131652" ], "products": [ "species_29372", "species_29370", "species_1467459" ], "modifiers": [ [ "species_10459316", "catalyst" ] ], "additional_components": [ "Q86B52", "FBgn0263747", "X2JG15", "FBgn0083956" ] }, "reaction_10490041": { "compartment": "compartment_12045", "id": "reaction_10490041", "reactome": "R-DME-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490038", "species_10426987" ], "products": [ "species_10490036" ], "modifiers": [ [ "species_10490038", "catalyst" ] ], "additional_components": [ "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VKC7", "FBgn0032398", "Q9V415", "FBgn0028475", "Q9VXP1", "FBgn0030693", "Q9VFY3", "FBgn0038125", "Q8IQM1", "FBgn0052847", "Q8IR26", "FBgn0052581", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VKC7", "FBgn0032398", "Q9V415", "FBgn0028475", "Q9VXP1", "FBgn0030693", "Q9VFY3", "FBgn0038125", "Q8IQM1", "FBgn0052847", "Q8IR26", "FBgn0052581", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VKC7", "FBgn0032398", "Q9V415", "FBgn0028475", "Q9VXP1", "FBgn0030693", "Q9VFY3", "FBgn0038125", "Q8IQM1", "FBgn0052847", "Q8IR26", "FBgn0052581", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207" ] }, "reaction_10490043": { "compartment": "compartment_70101", "id": "reaction_10490043", "reactome": "R-DME-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489994" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10459297": { "compartment": "compartment_70101", "id": "reaction_10459297", "reactome": "R-DME-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1454930" ], "products": [ "species_29372", "species_29370", "species_1454919" ], "modifiers": [ [ "species_10459294", "catalyst" ] ], "additional_components": [ "Q9VLN6", "FBgn0032026", "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793", "Q9VLP5", "FBgn0032018", "Q9VL32", "FBgn0028675", "Q7KTC0", "FBgn0032456" ] }, "reaction_10463004": { "compartment": "compartment_984", "id": "reaction_10463004", "reactome": "R-DME-2022141", "name": "Prolysyl oxidase activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462952" ], "products": [ "species_10462980", "species_10463002" ], "modifiers": [ [ "species_10462626", "catalyst" ] ], "additional_components": [ "Q9W2C9", "FBgn0034660", "Q9V9X5", "FBgn0039848", "Q9W2C9", "FBgn0034660", "Q9V9X5", "FBgn0039848", "Q9W2C9", "FBgn0034660", "Q9V9X5", "FBgn0039848", "Q9VC47", "FBgn0004885", "P25723", "FBgn0003719" ] }, "reaction_10465381": { "compartment": "compartment_984", "id": "reaction_10465381", "reactome": "R-DME-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459394" ], "products": [ "species_10465379" ], "modifiers": [], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10459396": { "compartment": "compartment_984", "id": "reaction_10459396", "reactome": "R-DME-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459392" ], "products": [ "species_10459394" ], "modifiers": [], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10433228": { "compartment": "compartment_5460", "id": "reaction_10433228", "reactome": "R-DME-77345", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77308", "species_113596" ], "products": [ "species_77343", "species_31649" ], "modifiers": [ [ "species_10433219", "catalyst" ] ], "additional_components": [ "Q9VSA3", "FBgn0035811" ] }, "reaction_10433226": { "compartment": "compartment_5460", "id": "reaction_10433226", "reactome": "R-DME-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10494966": { "compartment": "compartment_5460", "id": "reaction_10494966", "reactome": "R-DME-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10494963", "catalyst" ] ], "additional_components": [ "Q9V6U9", "FBgn0033883" ] }, "reaction_10433224": { "compartment": "compartment_5460", "id": "reaction_10433224", "reactome": "R-DME-77340", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77339" ], "products": [ "species_77337", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_390061": { "compartment": "compartment_70101", "id": "reaction_390061", "reactome": "R-DME-390061", "name": "YKI binds to phosphorylated WTS", "reversible": "false", "notes": "The transcriptional factor Yorkie (YKI) via it's two WW domains binds to activated Warts (WTS) kinase. However, it appears that this particular binding has no detectable influence on YKI phosphorylation.", "reactants": [ "species_390114", "species_390068" ], "products": [ "species_390067" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q45VV3", "yki", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390044": { "compartment": "compartment_70101", "id": "reaction_390044", "reactome": "R-DME-390044", "name": "YKI is phosphorylated by and then dissociates from phosphorylated WTS", "reversible": "false", "notes": "The transcription factor Yorkie (YKI) is phosphorylated at Ser111, Ser168 and Ser250 by the activated serine/threonine kinase Warts (WTS).", "reactants": [ "species_113592", "species_390067" ], "products": [ "species_29370", "species_390064", "species_390068" ], "modifiers": [ [ "species_390067", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q45VV3", "yki", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q45VV3", "yki", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390078": { "compartment": "compartment_70101", "id": "reaction_390078", "reactome": "R-DME-390078", "name": "14-3-3 dimer binds to phosphorylated YKI", "reversible": "false", "notes": "The phosphorylated transcription factor Yorkie (YKI) associates with either one of the two 14-3-3 dimer isoforms (14-3-3epsilon or 14-3-3zeta). This effectively anchors YKI in the cytosol and prevents it entering the nucleus to activate its target genes.", "reactants": [ "species_390066", "species_390064" ], "products": [ "species_390163" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "P29310", "14-3-3zeta", "Q45VV3", "yki", "P92177", "14-3-3epsilon", "P29310", "14-3-3zeta" ] }, "reaction_10450831": { "compartment": "compartment_70101", "id": "reaction_10450831", "reactome": "R-DME-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450827" ], "products": [ "species_113592", "species_10450825" ], "modifiers": [], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "species_113592", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563" ] }, "reaction_10495569": { "compartment": "compartment_70101", "id": "reaction_10495569", "reactome": "R-DME-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10495566", "catalyst" ] ], "additional_components": [ "Q8IRI6", "FBgn0264574" ] }, "reaction_10450829": { "compartment": "compartment_70101", "id": "reaction_10450829", "reactome": "R-DME-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10450825" ], "products": [ "species_10450827" ], "modifiers": [], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "species_113592" ] }, "reaction_10495571": { "compartment": "compartment_70101", "id": "reaction_10495571", "reactome": "R-DME-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10439537", "catalyst" ] ], "additional_components": [ "Q8IRI6", "FBgn0264574" ] }, "reaction_10448859": { "compartment": "compartment_876", "id": "reaction_10448859", "reactome": "R-DME-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10448856", "catalyst" ] ], "additional_components": [ "A8JQU1", "FBgn0037386", "Q9VQP0", "FBgn0053282", "A0A1Z1CGZ4", "FBgn0037485", "Q7K2U8", "FBgn0028560", "Q9VQN6", "FBgn0031517", "Q7JVN6", "FBgn0037387", "Q9VI79", "FBgn0037486", "Q9W3S8", "FBgn0029932", "P53403", "FBgn0015230", "Q8MLQ7", "FBgn0034909", "Q9VU17", "FBgn0036316", "Q8MKK4", "FBgn0033644", "Q9VQP2", "FBgn0031523", "A1ZA52", "FBgn0034045", "Q8IPZ9", "FBgn0053282", "Q9VQP1", "FBgn0031522", "A1Z8N1", "FBgn0050035", "Q7K3P6", "FBgn0034247" ] }, "reaction_10495557": { "compartment": "compartment_70101", "id": "reaction_10495557", "reactome": "R-DME-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10495554", "catalyst" ] ], "additional_components": [ "Q0IGX4", "FBgn0033047", "Q7KJP2", "FBgn0028561", "Q7KK97", "FBgn0028563", "Q9U622", "FBgn0028562" ] }, "reaction_10471641": { "compartment": "compartment_70101", "id": "reaction_10471641", "reactome": "R-DME-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10450825", "catalyst" ], [ "species_10471639", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "FBgn0014135" ] }, "reaction_10448729": { "compartment": "compartment_876", "id": "reaction_10448729", "reactome": "R-DME-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10448724", "catalyst" ] ], "additional_components": [ "species_964746", "species_29532", "species_964746", "species_29532", "FBgn0264574" ] }, "reaction_10448760": { "compartment": "compartment_876", "id": "reaction_10448760", "reactome": "R-DME-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10448757", "catalyst" ] ], "additional_components": [ "species_964746", "species_30034", "species_29532", "species_964746", "species_30034", "species_29532", "FBgn0264574" ] }, "reaction_10495562": { "compartment": "compartment_70101", "id": "reaction_10495562", "reactome": "R-DME-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10495559", "catalyst" ] ], "additional_components": [ "Q7KK97", "FBgn0028563" ] }, "reaction_10450834": { "compartment": "compartment_70101", "id": "reaction_10450834", "reactome": "R-DME-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10439537", "catalyst" ] ], "additional_components": [ "Q8IRI6", "FBgn0264574" ] }, "reaction_10448879": { "compartment": "compartment_876", "id": "reaction_10448879", "reactome": "R-DME-429594", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_264638", "species_74113" ], "products": [ "species_264618", "species_83910", "species_352022" ], "modifiers": [ [ "species_10448876", "catalyst" ] ], "additional_components": [ "FBgn0038641" ] }, "reaction_10449996": { "compartment": "compartment_876", "id": "reaction_10449996", "reactome": "R-DME-444120", "name": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_266029", "species_74113" ], "products": [ "species_83910", "species_352022", "species_29424" ], "modifiers": [ [ "species_10449993", "catalyst" ] ], "additional_components": [ "Q7K330", "FBgn0033443", "A1ZBC7", "FBgn0034381", "Q9VSV2", "FBgn0035969", "A1Z8V9", "FBgn0033708", "Q9VLY6", "FBgn0267326", "Q9VLY5", "FBgn0031935", "Q9VLY4", "FBgn0031936", "Q9VLY3", "FBgn0031937", "Q9VJR4", "FBgn0028886", "Q7KTJ8", "FBgn0053296", "Q9W4C5", "FBgn0029762", "Q9W1J0", "FBgn0034911" ] }, "reaction_10449963": { "compartment": "compartment_876", "id": "reaction_10449963", "reactome": "R-DME-444100", "name": "PROT mediates L-proline uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_352033", "species_74113" ], "products": [ "species_83910", "species_113538", "species_352022" ], "modifiers": [ [ "species_10449960", "catalyst" ] ], "additional_components": [ "Q9VLY5", "FBgn0031935", "Q9VLY4", "FBgn0031936", "Q9VLY3", "FBgn0031937", "Q9VJR4", "FBgn0028886", "Q7KTJ8", "FBgn0053296", "Q9W4C5", "FBgn0029762", "Q7K330", "FBgn0033443", "Q9W1J0", "FBgn0034911", "A1ZBC7", "FBgn0034381", "Q9VSV2", "FBgn0035969", "A1Z8V9", "FBgn0033708", "Q9VLY6", "FBgn0267326" ] }, "reaction_10444219": { "compartment": "compartment_876", "id": "reaction_10444219", "reactome": "R-DME-352059", "name": "SLC6A15-mediated amino acid uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352051", "species_74113" ], "products": [ "species_83910", "species_352048" ], "modifiers": [ [ "species_10444216", "catalyst" ] ], "additional_components": [ "species_29432", "species_29472", "CHEBI:58045", "species_379717", "species_351990", "species_111707", "species_200736", "species_29642", "species_351964", "species_379705", "species_6784215", "species_29702", "species_29472", "species_379717", "species_351990", "species_200736", "species_351964", "species_379705", "species_6784215", "CHEBI:58045", "species_29702", "species_29432", "species_29642", "species_111707", "Q8IQQ7", "FBgn0027660", "B7Z122", "FBgn0029663" ] }, "reaction_10450010": { "compartment": "compartment_876", "id": "reaction_10450010", "reactome": "R-DME-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10450007", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "species_114523", "species_390899", "species_351597", "species_351597", "CHEBI:28918", "species_390899", "species_380873", "species_114523", "Q8IH57", "FBgn0260964", "Q9VCJ5", "FBgn0043005" ] }, "reaction_10444839": { "compartment": "compartment_876", "id": "reaction_10444839", "reactome": "R-DME-374896", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10449926": { "compartment": "compartment_876", "id": "reaction_10449926", "reactome": "R-DME-443997", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935", "species_74113" ], "products": [ "species_209789", "species_83910" ], "modifiers": [ [ "species_10449923", "catalyst" ] ], "additional_components": [ "FBgn0034136" ] }, "reaction_10444198": { "compartment": "compartment_876", "id": "reaction_10444198", "reactome": "R-DME-351963", "name": "SLC6A18 transports Gly from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266029" ], "products": [ "species_29424" ], "modifiers": [ [ "species_10444195", "catalyst" ] ], "additional_components": [ "FBgn0029663" ] }, "reaction_10445109": { "compartment": "compartment_876", "id": "reaction_10445109", "reactome": "R-DME-375487", "name": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_375468", "species_74113" ], "products": [ "species_83910", "species_375459", "species_352022" ], "modifiers": [ [ "species_10445106", "catalyst" ] ], "additional_components": [ "species_29432", "species_29500", "CHEBI:58045", "species_29612", "species_200736", "species_29424", "species_29468", "species_73590", "species_29444", "species_111707", "species_351964", "species_379705", "species_29702", "species_200736", "species_29702", "species_29612", "species_29444", "species_29424", "species_351964", "species_379705", "CHEBI:58045", "species_73590", "species_29432", "species_111707", "species_29468", "species_29500", "A1ZBC7", "FBgn0034381", "Q9VJR4", "FBgn0028886", "Q9VLY5", "FBgn0031935", "Q9W1J0", "FBgn0034911", "A1Z8V9", "FBgn0033708", "Q7KTJ8", "FBgn0053296", "Q9VLY4", "FBgn0031936", "Q9VSV2", "FBgn0035969", "Q7K330", "FBgn0033443", "Q9VLY3", "FBgn0031937", "Q9VLY6", "FBgn0267326", "Q9W4C5", "FBgn0029762" ] }, "reaction_10445044": { "compartment": "compartment_876", "id": "reaction_10445044", "reactome": "R-DME-375473", "name": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375458", "species_74113" ], "products": [ "species_375481", "species_83910" ], "modifiers": [ [ "species_10445041", "catalyst" ] ], "additional_components": [ "species_29432", "species_29500", "species_29472", "CHEBI:58045", "species_111707", "species_200736", "species_29424", "species_351964", "species_379705", "species_29506", "species_29502", "species_29702", "species_29424", "species_29472", "species_29506", "species_200736", "species_351964", "species_379705", "CHEBI:58045", "species_29702", "species_29432", "species_111707", "species_29500", "species_29502", "Q8IQQ7", "FBgn0027660", "B7Z122", "FBgn0029663" ] }, "reaction_10444210": { "compartment": "compartment_876", "id": "reaction_10444210", "reactome": "R-DME-352052", "name": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033", "species_74113" ], "products": [ "species_83910", "species_113538" ], "modifiers": [ [ "species_10444207", "catalyst" ] ], "additional_components": [ "Q8IQQ7", "FBgn0027660", "B7Z122", "FBgn0029663" ] }, "reaction_10495345": { "compartment": "compartment_70101", "id": "reaction_10495345", "reactome": "R-DME-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10495342", "catalyst" ] ], "additional_components": [ "M9PEG6", "FBgn0035432", "Q9VPE3", "FBgn0037000" ] }, "reaction_10449676": { "compartment": "compartment_876", "id": "reaction_10449676", "reactome": "R-DME-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10449673", "catalyst" ] ], "additional_components": [ "FBgn0011672" ] }, "reaction_10449684": { "compartment": "compartment_876", "id": "reaction_10449684", "reactome": "R-DME-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10449681", "catalyst" ] ], "additional_components": [ "FBgn0037000" ] }, "reaction_10449699": { "compartment": "compartment_20699", "id": "reaction_10449699", "reactome": "R-DME-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10449696", "catalyst" ] ], "additional_components": [ "Q9VKA3", "FBgn0051860", "Q9V471", "FBgn0028516" ] }, "reaction_10449823": { "compartment": "compartment_876", "id": "reaction_10449823", "reactome": "R-DME-442387", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449820", "catalyst" ] ], "additional_components": [ "Q9VSL7", "FBgn0024236", "A4IJ72", "FBgn0036461" ] }, "reaction_10449831": { "compartment": "compartment_12045", "id": "reaction_10449831", "reactome": "R-DME-442393", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_442320" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449828", "catalyst" ] ], "additional_components": [ "FBgn0002022" ] }, "reaction_10449862": { "compartment": "compartment_876", "id": "reaction_10449862", "reactome": "R-DME-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449859", "catalyst" ] ], "additional_components": [ "Q9VFA2", "FBgn0038312", "Q9VEX1", "FBgn0038412", "Q7JZR2", "FBgn0033096", "A1Z6P0", "FBgn0033097", "Q9VSL7", "FBgn0024236" ] }, "reaction_10449812": { "compartment": "compartment_876", "id": "reaction_10449812", "reactome": "R-DME-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449809", "catalyst" ] ], "additional_components": [ "Q9VSL7", "FBgn0024236", "A4IJ72", "FBgn0036461" ] }, "reaction_10449712": { "compartment": "compartment_876", "id": "reaction_10449712", "reactome": "R-DME-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10449709", "catalyst" ] ], "additional_components": [ "FBgn0062413" ] }, "reaction_10449872": { "compartment": "compartment_876", "id": "reaction_10449872", "reactome": "R-DME-442661", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10449867", "catalyst" ] ], "additional_components": [ "FBgn0053181" ] }, "reaction_10450071": { "compartment": "compartment_984", "id": "reaction_10450071", "reactome": "R-DME-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10450068", "catalyst" ] ], "additional_components": [ "Q9VAP3", "FBgn0039637", "Q9VZE7", "FBgn0035523" ] }, "reaction_10449579": { "compartment": "compartment_876", "id": "reaction_10449579", "reactome": "R-DME-433104", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433138", "species_74113" ], "products": [ "species_76190", "species_83910" ], "modifiers": [ [ "species_10449576", "catalyst" ] ], "additional_components": [ "FBgn0036816" ] }, "reaction_10449561": { "compartment": "compartment_876", "id": "reaction_10449561", "reactome": "R-DME-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10449558", "catalyst" ] ], "additional_components": [ "Q9VDQ0", "FBgn0260466", "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816" ] }, "reaction_10449592": { "compartment": "compartment_876", "id": "reaction_10449592", "reactome": "R-DME-433114", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10449589", "catalyst" ] ], "additional_components": [ "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816", "Q9VDQ0", "FBgn0260466" ] }, "reaction_10449574": { "compartment": "compartment_876", "id": "reaction_10449574", "reactome": "R-DME-433101", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433123", "species_74113" ], "products": [ "species_29434", "species_83910" ], "modifiers": [ [ "species_10449571", "catalyst" ] ], "additional_components": [ "Q9VDQ0", "FBgn0260466", "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816" ] }, "reaction_10449605": { "compartment": "compartment_876", "id": "reaction_10449605", "reactome": "R-DME-433131", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433111", "species_74113" ], "products": [ "species_83910", "species_433124" ], "modifiers": [ [ "species_10449602", "catalyst" ] ], "additional_components": [ "species_29654", "species_29434", "species_29434", "species_29654", "Q9VDQ0", "FBgn0260466", "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816" ] }, "reaction_10453615": { "compartment": "compartment_876", "id": "reaction_10453615", "reactome": "R-DME-561054", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549266" ], "products": [ "species_549237" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:6801", "CHEBI:16797", "CHEBI:16737", "species_264638", "CHEBI:65133", "CHEBI:641", "species_114523", "species_351164", "species_390899", "CHEBI:31941", "species_351597", "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_351597", "CHEBI:65133", "species_351164", "species_390899", "species_264638", "CHEBI:16797", "species_114523", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10453453": { "compartment": "compartment_876", "id": "reaction_10453453", "reactome": "R-DME-549297", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10453450", "catalyst" ] ], "additional_components": [ "Q9VD40", "FBgn0038938", "Q9VCA0", "FBgn0039178", "Q961R9", "FBgn0038407", "A2RVG5", "FBgn0063649", "Q9VNX2", "FBgn0037140", "Q9VNW8", "FBgn0037144", "Q9VEY1", "FBgn0038404" ] }, "reaction_10453430": { "compartment": "compartment_876", "id": "reaction_10453430", "reactome": "R-DME-549279", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549237" ], "products": [ "species_549266" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_351597", "CHEBI:65133", "species_351164", "species_390899", "species_264638", "CHEBI:16797", "species_114523", "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:6801", "CHEBI:16797", "CHEBI:16737", "species_264638", "CHEBI:65133", "CHEBI:641", "species_114523", "species_351164", "species_390899", "CHEBI:31941", "species_351597", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10453654": { "compartment": "compartment_876", "id": "reaction_10453654", "reactome": "R-DME-561072", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549255" ], "products": [ "species_549326" ], "modifiers": [ [ "species_10453455", "catalyst" ] ], "additional_components": [ "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "FBgn0034479" ] }, "reaction_10453365": { "compartment": "compartment_876", "id": "reaction_10453365", "reactome": "R-DME-549129", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549264" ], "products": [ "species_549250" ], "modifiers": [ [ "species_10453362", "catalyst" ] ], "additional_components": [ "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_141324", "CHEBI:15854", "species_351597", "CHEBI:65133", "species_390899", "species_141342", "species_264638", "CHEBI:16797", "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "CHEBI:16797", "species_264638", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_141342", "species_351597", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "D2NUL5", "FBgn0264907", "Q9VDS2", "FBgn0038750" ] }, "reaction_10453460": { "compartment": "compartment_876", "id": "reaction_10453460", "reactome": "R-DME-549322", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549250" ], "products": [ "species_549264" ], "modifiers": [ [ "species_10453362", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "CHEBI:16797", "species_264638", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_141342", "species_351597", "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_141324", "CHEBI:15854", "species_351597", "CHEBI:65133", "species_390899", "species_141342", "species_264638", "CHEBI:16797", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "D2NUL5", "FBgn0264907", "Q9VDS2", "FBgn0038750" ] }, "reaction_10453458": { "compartment": "compartment_876", "id": "reaction_10453458", "reactome": "R-DME-549304", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549326" ], "products": [ "species_549255" ], "modifiers": [ [ "species_10453455", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "FBgn0034479" ] }, "reaction_10453426": { "compartment": "compartment_876", "id": "reaction_10453426", "reactome": "R-DME-549241", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549261", "species_74113" ], "products": [ "species_83910", "species_549260" ], "modifiers": [ [ "species_10453401", "catalyst" ], [ "species_10453424", "inhibitor" ] ], "additional_components": [ "Q9VCA0", "FBgn0039178", "Q961R9", "FBgn0038407", "A2RVG5", "FBgn0063649", "Q9VNX2", "FBgn0037140", "Q9VNW8", "FBgn0037144", "Q9VEY1", "FBgn0038404", "Q9VD40", "FBgn0038938", "M9PI08", "FBgn0083981", "Q9W349", "FBgn0002576", "Q9VRA9", "FBgn0259162", "P22814", "FBgn0003300" ] }, "reaction_10453613": { "compartment": "compartment_876", "id": "reaction_10453613", "reactome": "R-DME-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561049" ], "products": [ "species_561078", "species_561075" ], "modifiers": [ [ "species_10453610", "catalyst" ] ], "additional_components": [ "CHEBI:104011", "species_561052", "species_561052", "CHEBI:104011", "Q9VDV8", "FBgn0038717", "Q9VRQ8", "FBgn0035645", "Q9VDV7", "FBgn0038718", "Q9VFG2", "FBgn0038260", "Q9VDV6", "FBgn0038719", "Q9VFG1", "FBgn0038261", "Q9VDV5", "FBgn0038720", "Q9VFG0", "FBgn0038262", "Q9VCA2", "FBgn0019952", "Q9VDW0", "FBgn0038715", "Q9VRT4", "FBgn0259164", "Q95R48", "FBgn0086365", "Q9VDV9", "FBgn0038716", "Q9VRR0", "FBgn0035647", "Q86NP5", "FBgn0053233" ] }, "reaction_10453689": { "compartment": "compartment_876", "id": "reaction_10453689", "reactome": "R-DME-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10453686", "catalyst" ] ], "additional_components": [ "Q9VDV5", "FBgn0038720", "Q9VCA2", "FBgn0019952", "Q95R48", "FBgn0086365", "Q86NP5", "FBgn0053233", "Q9VRT4", "FBgn0259164", "Q9VRR0", "FBgn0035647", "Q9VRQ8", "FBgn0035645", "Q9VFG2", "FBgn0038260", "Q9VFG1", "FBgn0038261", "Q9VFG0", "FBgn0038262", "Q9VDW0", "FBgn0038715", "Q9VDV9", "FBgn0038716", "Q9VDV8", "FBgn0038717", "Q9VDV7", "FBgn0038718", "Q9VDV6", "FBgn0038719" ] }, "reaction_10453652": { "compartment": "compartment_876", "id": "reaction_10453652", "reactome": "R-DME-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561071" ], "products": [ "species_561062", "species_561075" ], "modifiers": [ [ "species_10453649", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176501", "species_176496", "Q9VDV9", "FBgn0038716", "Q9VDV8", "FBgn0038717", "Q9VDV7", "FBgn0038718", "Q9VDV6", "FBgn0038719", "Q9VDV5", "FBgn0038720", "Q9VCA2", "FBgn0019952", "Q95R48", "FBgn0086365", "Q86NP5", "FBgn0053233", "Q9VRT4", "FBgn0259164", "Q9VRR0", "FBgn0035647", "Q9VRQ8", "FBgn0035645", "Q9VFG2", "FBgn0038260", "Q9VFG1", "FBgn0038261", "Q9VFG0", "FBgn0038262", "Q9VDW0", "FBgn0038715" ] }, "reaction_10449536": { "compartment": "compartment_876", "id": "reaction_10449536", "reactome": "R-DME-433089", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433120", "species_74113" ], "products": [ "species_83910", "species_176483" ], "modifiers": [ [ "species_10449533", "catalyst" ] ], "additional_components": [ "Q9VXV4", "FBgn0030638", "Q9VXF5", "FBgn0030756" ] }, "reaction_10450045": { "compartment": "compartment_876", "id": "reaction_10450045", "reactome": "R-DME-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10450042", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450557": { "compartment": "compartment_876", "id": "reaction_10450557", "reactome": "R-DME-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10450047", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450555": { "compartment": "compartment_876", "id": "reaction_10450555", "reactome": "R-DME-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10450037", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450040": { "compartment": "compartment_876", "id": "reaction_10450040", "reactome": "R-DME-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10450037", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450050": { "compartment": "compartment_876", "id": "reaction_10450050", "reactome": "R-DME-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10450047", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10436318": { "compartment": "compartment_70616", "id": "reaction_10436318", "reactome": "R-DME-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113581", "species_113592" ], "modifiers": [ [ "species_10436315", "catalyst" ] ], "additional_components": [ "Q26365", "FBgn0003360", "O62526", "FBgn0025111" ] }, "reaction_10433387": { "compartment": "compartment_70101", "id": "reaction_10433387", "reactome": "R-DME-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10433362", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "FBgn0031250" ] }, "reaction_10453898": { "compartment": "compartment_70101", "id": "reaction_10453898", "reactome": "R-DME-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10453895", "catalyst" ] ], "additional_components": [ "species_83908", "species_83927", "CHEBI:16704", "CHEBI:16750", "CHEBI:17562", "CHEBI:17748", "species_83951", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_83951", "FBgn0031250" ] }, "reaction_10433401": { "compartment": "compartment_70101", "id": "reaction_10433401", "reactome": "R-DME-109539", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179740", "species_74113" ], "products": [ "species_179741", "species_83910" ], "modifiers": [ [ "species_10433398", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83908", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "Q7K4A1", "FBgn0025709", "A1Z7N3", "FBgn0033371" ] }, "reaction_10433385": { "compartment": "compartment_70101", "id": "reaction_10433385", "reactome": "R-DME-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10433362", "catalyst" ] ], "additional_components": [ "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "FBgn0031250" ] }, "reaction_10433367": { "compartment": "compartment_70101", "id": "reaction_10433367", "reactome": "R-DME-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10433360", "catalyst" ] ], "additional_components": [ "species_83908", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_29692", "species_29554", "CHEBI:17562", "species_83951", "species_113599", "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "CHEBI:17748", "species_113599", "species_83908", "species_29692", "species_29554", "species_83951", "CHEBI:17562", "CHEBI:16040", "FBgn0031250" ] }, "reaction_10433382": { "compartment": "compartment_70101", "id": "reaction_10433382", "reactome": "R-DME-109530", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179738", "species_74113" ], "products": [ "species_179739", "species_83910" ], "modifiers": [ [ "species_10433379", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "CHEBI:17256", "CHEBI:17256", "species_83908", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "A1Z7N3", "FBgn0033371", "Q7K4A1", "FBgn0025709" ] }, "reaction_10453910": { "compartment": "compartment_70101", "id": "reaction_10453910", "reactome": "R-DME-727768", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727737" ], "products": [ "species_727774" ], "modifiers": [ [ "species_10453890", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "species_83908", "species_114523", "species_351597", "species_351597", "species_83908", "species_114523", "species_380873", "CHEBI:28918", "FBgn0036319" ] }, "reaction_10433365": { "compartment": "compartment_70101", "id": "reaction_10433365", "reactome": "R-DME-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10433360", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "CHEBI:17748", "species_113599", "species_83908", "species_29692", "species_29554", "species_83951", "CHEBI:17562", "CHEBI:16040", "species_83908", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_29692", "species_29554", "CHEBI:17562", "species_83951", "species_113599", "FBgn0031250" ] }, "reaction_10453893": { "compartment": "compartment_70101", "id": "reaction_10453893", "reactome": "R-DME-727740", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727774" ], "products": [ "species_727737" ], "modifiers": [ [ "species_10453890", "catalyst" ] ], "additional_components": [ "species_351597", "species_83908", "species_114523", "species_380873", "CHEBI:28918", "species_380873", "CHEBI:28918", "species_83908", "species_114523", "species_351597", "FBgn0036319" ] }, "reaction_10433392": { "compartment": "compartment_70101", "id": "reaction_10433392", "reactome": "R-DME-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_179743", "species_83910" ], "modifiers": [ [ "species_10433389", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "FBgn0025709" ] }, "reaction_10454262": { "compartment": "compartment_876", "id": "reaction_10454262", "reactome": "R-DME-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10454259", "catalyst" ] ], "additional_components": [ "CHEBI:16196", "CHEBI:16196", "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10453918": { "compartment": "compartment_20699", "id": "reaction_10453918", "reactome": "R-DME-727807", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727810", "species_4085435" ], "products": [ "species_727815", "species_109395" ], "modifiers": [ [ "species_10453915", "catalyst" ] ], "additional_components": [ "FBgn0024994" ] }, "reaction_10453946": { "compartment": "compartment_20699", "id": "reaction_10453946", "reactome": "R-DME-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10453943", "catalyst" ] ], "additional_components": [ "FBgn0265351" ] }, "reaction_10453962": { "compartment": "compartment_20699", "id": "reaction_10453962", "reactome": "R-DME-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_113578", "species_744233" ], "modifiers": [ [ "species_10453959", "catalyst" ] ], "additional_components": [ "FBgn0042641" ] }, "reaction_10453957": { "compartment": "compartment_20699", "id": "reaction_10453957", "reactome": "R-DME-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10453951", "catalyst" ] ], "additional_components": [ "FBgn0029849" ] }, "reaction_10453923": { "compartment": "compartment_20699", "id": "reaction_10453923", "reactome": "R-DME-735702", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_735692" ], "products": [ "species_109402", "species_735691" ], "modifiers": [ [ "species_10453920", "catalyst" ] ], "additional_components": [ "species_735700", "species_735682", "species_735682", "species_735700", "FBgn0024994" ] }, "reaction_10453938": { "compartment": "compartment_20699", "id": "reaction_10453938", "reactome": "R-DME-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10453935", "catalyst" ] ], "additional_components": [ "Q9VVD9", "FBgn0036695", "Q9VEI3", "FBgn0038524" ] }, "reaction_10453954": { "compartment": "compartment_20699", "id": "reaction_10453954", "reactome": "R-DME-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10453951", "catalyst" ] ], "additional_components": [ "FBgn0029849" ] }, "reaction_10453906": { "compartment": "compartment_20699", "id": "reaction_10453906", "reactome": "R-DME-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10453903", "catalyst" ] ], "additional_components": [ "FBgn0036662" ] }, "reaction_10454239": { "compartment": "compartment_876", "id": "reaction_10454239", "reactome": "R-DME-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10454236", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q9VLB3", "FBgn0032123", "C8VV48", "FBgn0001296", "Q9W270", "FBgn0034715", "Q9VK82", "FBgn0032435", "Q9W269", "FBgn0034716", "Q8SY02", "FBgn0051634", "Q9VVH9", "FBgn0036732", "Q9W271", "FBgn0050277", "Q9VK84", "FBgn0032433" ] }, "reaction_10454189": { "compartment": "compartment_876", "id": "reaction_10454189", "reactome": "R-DME-879562", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879553" ], "products": [ "species_879654" ], "modifiers": [ [ "species_10454186", "catalyst" ] ], "additional_components": [ "species_176496", "CHEBI:63836", "species_176501", "CHEBI:63836", "species_176501", "species_176496", "FBgn0032123" ] }, "reaction_10454267": { "compartment": "compartment_876", "id": "reaction_10454267", "reactome": "R-DME-879594", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879521" ], "products": [ "species_879517" ], "modifiers": [ [ "species_10454264", "catalyst" ] ], "additional_components": [ "FBgn0051634" ] }, "reaction_10497799": { "compartment": "compartment_876", "id": "reaction_10497799", "reactome": "R-DME-9631987", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10454191", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "FBgn0032123" ] }, "reaction_10454184": { "compartment": "compartment_876", "id": "reaction_10454184", "reactome": "R-DME-879528", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879566" ], "products": [ "species_879614" ], "modifiers": [ [ "species_10454181", "catalyst" ] ], "additional_components": [ "species_879535", "CHEBI:15544", "species_416911", "species_265287", "species_416911", "CHEBI:15544", "species_879535", "species_265287", "FBgn0032123" ] }, "reaction_10448447": { "compartment": "compartment_876", "id": "reaction_10448447", "reactome": "R-DME-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428027", "species_29804", "species_74113" ], "products": [ "species_74126", "species_427997", "species_70106", "species_83910" ], "modifiers": [ [ "species_10442846", "catalyst" ] ], "additional_components": [ "species_113553", "species_6810061", "species_210382", "species_113553", "species_6810061", "species_210382", "FBgn0026438" ] }, "reaction_10448637": { "compartment": "compartment_201753", "id": "reaction_10448637", "reactome": "R-DME-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428592", "species_428548" ], "products": [ "species_428632", "species_70106" ], "modifiers": [ [ "species_10448634", "catalyst" ] ], "additional_components": [ "species_29424", "species_352011", "species_352011", "species_29424", "FBgn0033911" ] }, "reaction_10474318": { "compartment": "compartment_70101", "id": "reaction_10474318", "reactome": "R-DME-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10474315", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10448410": { "compartment": "compartment_876", "id": "reaction_10448410", "reactome": "R-DME-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10448405", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10448393": { "compartment": "compartment_876", "id": "reaction_10448393", "reactome": "R-DME-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10448390", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10448388": { "compartment": "compartment_876", "id": "reaction_10448388", "reactome": "R-DME-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_427648" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10448383", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10491197": { "compartment": "compartment_70101", "id": "reaction_10491197", "reactome": "R-DME-8875871", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648" ], "products": [ "species_174375" ], "modifiers": [ [ "species_10491194", "catalyst" ] ], "additional_components": [ "FBgn0036240" ] }, "reaction_10491278": { "compartment": "compartment_70101", "id": "reaction_10491278", "reactome": "R-DME-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876310", "species_74113" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10491275", "catalyst" ] ], "additional_components": [ "species_113557", "species_373863", "species_8869604", "species_113557", "species_373863", "species_197230", "P83740", "FBgn0052669", "Q8SWV5", "FBgn0034494" ] }, "reaction_10489060": { "compartment": "compartment_70101", "id": "reaction_10489060", "reactome": "R-DME-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_2162265", "species_71285" ], "modifiers": [ [ "species_10489057", "catalyst" ] ], "additional_components": [ "FBgn0039357" ] }, "reaction_10448403": { "compartment": "compartment_876", "id": "reaction_10448403", "reactome": "R-DME-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10448398", "catalyst" ] ], "additional_components": [ "FBgn0260795" ] }, "reaction_10448445": { "compartment": "compartment_876", "id": "reaction_10448445", "reactome": "R-DME-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_428026", "species_70106" ], "modifiers": [ [ "species_10448442", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:47923", "CHEBI:90799", "FBgn0028491" ] }, "reaction_10471671": { "compartment": "compartment_70101", "id": "reaction_10471671", "reactome": "R-DME-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_5673778" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10471668", "catalyst" ] ], "additional_components": [ "FBgn0039045" ] }, "reaction_10448940": { "compartment": "compartment_876", "id": "reaction_10448940", "reactome": "R-DME-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10448934", "catalyst" ] ], "additional_components": [ "FBgn0034494" ] }, "reaction_10448937": { "compartment": "compartment_876", "id": "reaction_10448937", "reactome": "R-DME-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429739", "species_74113" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10448934", "catalyst" ] ], "additional_components": [ "species_113557", "species_373863", "species_8869604", "CHEBI:30772", "species_29416", "CHEBI:30768", "CHEBI:30772", "species_113557", "species_29416", "species_373863", "CHEBI:30768", "species_197230", "FBgn0034494" ] }, "reaction_10448456": { "compartment": "compartment_201753", "id": "reaction_10448456", "reactome": "R-DME-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10448449", "catalyst" ] ], "additional_components": [ "FBgn0031424" ] }, "reaction_10448871": { "compartment": "compartment_876", "id": "reaction_10448871", "reactome": "R-DME-429591", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10442820", "catalyst" ] ], "additional_components": [ "P83740", "FBgn0052669", "Q8SWV5", "FBgn0034494" ] }, "reaction_10448629": { "compartment": "compartment_17938", "id": "reaction_10448629", "reactome": "R-DME-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_428633", "species_70106" ], "modifiers": [ [ "species_10448626", "catalyst" ] ], "additional_components": [ "FBgn0030452" ] }, "reaction_10491181": { "compartment": "compartment_70101", "id": "reaction_10491181", "reactome": "R-DME-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_113529", "species_113552" ], "modifiers": [ [ "species_10491178", "catalyst" ] ], "additional_components": [ "Q9VGF7", "FBgn0260743", "Q8INJ3", "FBgn0037970" ] }, "reaction_10460673": { "compartment": "compartment_70616", "id": "reaction_10460673", "reactome": "R-DME-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_1614584" ], "products": [ "species_113544", "species_174375" ], "modifiers": [ [ "species_10444381", "catalyst" ] ], "additional_components": [ "FBgn0027610" ] }, "reaction_10444384": { "compartment": "compartment_70101", "id": "reaction_10444384", "reactome": "R-DME-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10444381", "catalyst" ] ], "additional_components": [ "FBgn0027610" ] }, "reaction_10445035": { "compartment": "compartment_876", "id": "reaction_10445035", "reactome": "R-DME-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10445032", "catalyst" ] ], "additional_components": [ "species_29432", "species_379717", "species_29424", "species_29424", "species_379717", "species_29432", "FBgn0032036" ] }, "reaction_10445030": { "compartment": "compartment_876", "id": "reaction_10445030", "reactome": "R-DME-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10445027", "catalyst" ] ], "additional_components": [ "species_379717", "species_29424", "species_29424", "species_379717", "M9PEU1", "FBgn0263776", "Q7K2W3", "FBgn0033760", "Q9VT04", "FBgn0036007", "Q9VX84", "FBgn0030816", "Q4V5R4", "FBgn0033572", "Q9VLM3", "FBgn0032036", "Q9VTD7", "FBgn0036116", "M9PHT8", "FBgn0030817", "Q8IQF3", "FBgn0052081", "Q9VTD5", "FBgn0052079", "Q9W056", "FBgn0035300" ] }, "reaction_10448095": { "compartment": "compartment_876", "id": "reaction_10448095", "reactome": "R-DME-425482", "name": "SLC4A1,2,3 exchanges HCO3- for Cl-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10448088", "catalyst" ] ], "additional_components": [ "FBgn0036043" ] }, "reaction_10448107": { "compartment": "compartment_876", "id": "reaction_10448107", "reactome": "R-DME-425483", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10448100", "catalyst" ] ], "additional_components": [ "FBgn0259111" ] }, "reaction_10491757": { "compartment": "compartment_876", "id": "reaction_10491757", "reactome": "R-DME-8878664", "name": "SLC4A4 cotransports Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10491752", "catalyst" ], [ "species_10491755", "catalyst" ] ], "additional_components": [ "FBgn0259111", "FBgn0035371" ] }, "reaction_10448114": { "compartment": "compartment_876", "id": "reaction_10448114", "reactome": "R-DME-425577", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_425425", "species_352022", "species_74113" ], "products": [ "species_351626", "species_188972", "species_111627", "species_83910" ], "modifiers": [ [ "species_10448109", "catalyst" ] ], "additional_components": [ "FBgn0259111" ] }, "reaction_10474206": { "compartment": "compartment_263163", "id": "reaction_10474206", "reactome": "R-DME-5626316", "name": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5626313", "species_83910", "species_167012" ], "products": [ "species_29804", "species_74016", "species_425958" ], "modifiers": [ [ "species_10474203", "catalyst" ] ], "additional_components": [ "Q9VN12", "FBgn0037238", "Q7PLW4", "FBgn0039941", "Q5LJX8", "FBgn0265767", "A8Y5A2", "FBgn0040031" ] }, "reaction_10448158": { "compartment": "compartment_876", "id": "reaction_10448158", "reactome": "R-DME-425822", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425815", "species_74016" ], "products": [ "species_425810", "species_74112" ], "modifiers": [ [ "species_10448155", "catalyst" ] ], "additional_components": [ "FBgn0033324" ] }, "reaction_10448150": { "compartment": "compartment_876", "id": "reaction_10448150", "reactome": "R-DME-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_74126", "species_83910", "species_74112" ], "modifiers": [ [ "species_10448147", "catalyst" ] ], "additional_components": [ "Q9VN12", "FBgn0037238", "Q9U6A0", "FBgn0028704", "Q7PLW4", "FBgn0039941", "Q5LJX8", "FBgn0265767", "A8Y5A2", "FBgn0040031" ] }, "reaction_10444254": { "compartment": "compartment_876", "id": "reaction_10444254", "reactome": "R-DME-352379", "name": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352036", "species_29472", "species_74113" ], "products": [ "species_29432", "species_83910", "species_212615", "species_74113" ], "modifiers": [ [ "species_10444251", "catalyst" ] ], "additional_components": [ "FBgn0026438" ] }, "reaction_10445150": { "compartment": "compartment_876", "id": "reaction_10445150", "reactome": "R-DME-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445126", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q9VNP7", "FBgn0037203", "Q2PDY3", "FBgn0036493", "Q9VVM0", "FBgn0036764" ] }, "reaction_10445148": { "compartment": "compartment_876", "id": "reaction_10445148", "reactome": "R-DME-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445145", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q9VVM0", "FBgn0036764", "Q9VNP7", "FBgn0037203", "Q2PDY3", "FBgn0036493" ] }, "reaction_10495333": { "compartment": "compartment_70101", "id": "reaction_10495333", "reactome": "R-DME-8959781", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959777" ], "products": [ "species_8959775" ], "modifiers": [ [ "species_10495330", "catalyst" ] ], "additional_components": [ "CHEBI:28229", "species_113585", "species_29468", "species_29612", "species_29444", "CHEBI:27747", "species_113585", "species_29444", "species_29468", "species_29612", "CHEBI:28229", "CHEBI:27747", "FBgn0032219" ] }, "reaction_10444249": { "compartment": "compartment_876", "id": "reaction_10444249", "reactome": "R-DME-352371", "name": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352355", "species_352000", "species_74113" ], "products": [ "species_83910", "species_351990", "species_352359", "species_74113" ], "modifiers": [ [ "species_10444240", "catalyst" ] ], "additional_components": [ "species_200736", "species_351990", "species_29432", "species_111707", "species_29432", "species_351990", "species_111707", "species_200736", "FBgn0026438" ] }, "reaction_10445650": { "compartment": "compartment_876", "id": "reaction_10445650", "reactome": "R-DME-379432", "name": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29588", "species_379430" ], "products": [ "species_351964", "species_379440" ], "modifiers": [ [ "species_10445647", "catalyst" ] ], "additional_components": [ "species_379444", "species_29444", "species_29468", "species_379444", "species_29468", "species_29444", "Q8IR48", "FBgn0030574", "A1Z7E8", "FBgn0033294", "A1Z7F3", "FBgn0033297", "P07192", "FBgn0002571", "A0A4P1SA55", "FBgn0032382", "A1Z7F2", "FBgn0033296", "P07191", "FBgn0002569", "Q9VKE6", "FBgn0032381", "A1Z7F1", "FBgn0050360", "P07190", "FBgn0002570", "Q5U124", "FBgn0050359" ] }, "reaction_10445137": { "compartment": "compartment_876", "id": "reaction_10445137", "reactome": "R-DME-375770", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445134", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "FBgn0032911" ] }, "reaction_10490484": { "compartment": "compartment_876", "id": "reaction_10490484", "reactome": "R-DME-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10490478", "catalyst" ] ], "additional_components": [ "Q8IQF3", "FBgn0052081", "Q9VLM3", "FBgn0032036", "Q9VT04", "FBgn0036007", "Q9VTD5", "FBgn0052079", "M9PEU1", "FBgn0263776", "Q9VTD7", "FBgn0036116", "M9PHT8", "FBgn0030817", "Q9VX84", "FBgn0030816", "Q4V5R4", "FBgn0033572", "Q9W056", "FBgn0035300", "Q7K2W3", "FBgn0033760" ] }, "reaction_10445129": { "compartment": "compartment_876", "id": "reaction_10445129", "reactome": "R-DME-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445126", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q9VNP7", "FBgn0037203", "Q2PDY3", "FBgn0036493", "Q9VVM0", "FBgn0036764" ] }, "reaction_10444227": { "compartment": "compartment_876", "id": "reaction_10444227", "reactome": "R-DME-352158", "name": "SLC16A10-mediated uptake of aromatic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352161" ], "products": [ "species_352139" ], "modifiers": [ [ "species_10444224", "catalyst" ] ], "additional_components": [ "species_29500", "species_29506", "species_29502", "species_29506", "species_29500", "species_29502", "FBgn0001296" ] }, "reaction_10431078": { "compartment": "compartment_7660", "id": "reaction_10431078", "reactome": "R-DME-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431074", "species_10431069" ], "products": [ "species_10431076" ], "modifiers": [], "additional_components": [ "FBgn0032988", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9V9M6", "FBgn0032988" ] }, "reaction_10431182": { "compartment": "compartment_7660", "id": "reaction_10431182", "reactome": "R-DME-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431176" ], "products": [ "species_10431074", "species_10431180" ], "modifiers": [], "additional_components": [ "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9V9M6", "FBgn0032988", "Q9VH20", "FBgn0037792", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "FBgn0032988", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9VH20", "FBgn0037792", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10431966": { "compartment": "compartment_350", "id": "reaction_10431966", "reactome": "R-DME-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74985", "species_30595" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10431180", "catalyst" ] ], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9VH20", "FBgn0037792", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10457357": { "compartment": "compartment_70101", "id": "reaction_10457357", "reactome": "R-DME-984689", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457269" ], "products": [ "species_10457271" ], "modifiers": [], "additional_components": [ "FBgn0040232", "Q9VKI0", "FBgn0040232" ] }, "reaction_10457355": { "compartment": "compartment_70101", "id": "reaction_10457355", "reactome": "R-DME-984671", "name": "Chromokinesins form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450203" ], "products": [ "species_10457237" ], "modifiers": [], "additional_components": [ "FBgn0011606", "Q9XZ29", "FBgn0011606" ] }, "reaction_10457353": { "compartment": "compartment_70101", "id": "reaction_10457353", "reactome": "R-DME-984648", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457250", "species_10457255" ], "products": [ "species_10457257" ], "modifiers": [], "additional_components": [ "Q9VZF5", "FBgn0011692", "FBgn0086356", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692" ] }, "reaction_10457208": { "compartment": "compartment_70101", "id": "reaction_10457208", "reactome": "R-DME-983194", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457202", "species_10457191" ], "products": [ "species_10457206" ], "modifiers": [], "additional_components": [ "FBgn0001308", "FBgn0010235", "P46824", "FBgn0010235", "P17210", "FBgn0001308" ] }, "reaction_10457351": { "compartment": "compartment_70101", "id": "reaction_10457351", "reactome": "R-DME-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457242" ], "products": [ "species_10457244" ], "modifiers": [], "additional_components": [ "FBgn0004378", "P46863", "FBgn0004378" ] }, "reaction_10457365": { "compartment": "compartment_70101", "id": "reaction_10457365", "reactome": "R-DME-990489", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457363" ], "products": [ "species_10457311" ], "modifiers": [], "additional_components": [ "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268" ] }, "reaction_10457349": { "compartment": "compartment_70101", "id": "reaction_10457349", "reactome": "R-DME-983259", "name": "Kinesins move along microtubules consuming ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457347", "species_113592" ], "products": [ "species_10457347", "species_29370" ], "modifiers": [], "additional_components": [ "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379", "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379" ] }, "reaction_10457361": { "compartment": "compartment_70101", "id": "reaction_10457361", "reactome": "R-DME-984733", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457359" ], "products": [ "species_10457233" ], "modifiers": [], "additional_components": [ "Q9VRK9", "FBgn0004380", "Q9VRK9", "FBgn0004380" ] }, "reaction_10450651": { "compartment": "compartment_70101", "id": "reaction_10450651", "reactome": "R-DME-448702", "name": "Caspase-1 active tetramer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450627" ], "products": [ "species_10450649" ], "modifiers": [], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd" ] }, "reaction_10450629": { "compartment": "compartment_70101", "id": "reaction_10450629", "reactome": "R-DME-448673", "name": "Formation of caspase-1 p10/p20 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450625", "species_10450619" ], "products": [ "species_10450627" ], "modifiers": [], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd" ] }, "reaction_10442686": { "compartment": "compartment_70101", "id": "reaction_10442686", "reactome": "R-DME-209063", "name": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442681", "species_10426987" ], "products": [ "species_10442683" ], "modifiers": [ [ "species_10442677", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10451597": { "compartment": "compartment_70101", "id": "reaction_10451597", "reactome": "R-DME-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451588" ], "products": [ "species_10451594" ], "modifiers": [ [ "species_10451588", "catalyst" ] ], "additional_components": [ "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "O77237", "FBgn0025574", "O77237", "FBgn0025574", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "O77237", "FBgn0025574" ] }, "reaction_10442695": { "compartment": "compartment_70101", "id": "reaction_10442695", "reactome": "R-DME-209125", "name": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442677", "species_10442679" ], "products": [ "species_10442681" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10442693": { "compartment": "compartment_70101", "id": "reaction_10442693", "reactome": "R-DME-209087", "name": "IKBA is phosphorylated by Phospho IKKB kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437415" ], "products": [ "species_29370", "species_10437421" ], "modifiers": [ [ "species_10442690", "catalyst" ] ], "additional_components": [] }, "reaction_10450611": { "compartment": "compartment_70101", "id": "reaction_10450611", "reactome": "R-DME-446877", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450601" ], "products": [ "species_10450608" ], "modifiers": [ [ "species_10450601", "catalyst" ] ], "additional_components": [ "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "Q9W3I9", "FBgn0265464", "Q9W3I9", "FBgn0265464", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "Q9W3I9", "FBgn0265464" ] }, "reaction_10442673": { "compartment": "compartment_70101", "id": "reaction_10442673", "reactome": "R-DME-209061", "name": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442671" ], "products": [ "species_10437411", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10495861": { "compartment": "compartment_984", "id": "reaction_10495861", "reactome": "R-DME-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_29370", "species_10437429" ], "modifiers": [], "additional_components": [] }, "reaction_10496003": { "compartment": "compartment_70101", "id": "reaction_10496003", "reactome": "R-DME-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10445855" ], "products": [ "species_29370", "species_10495728" ], "modifiers": [], "additional_components": [] }, "reaction_10495919": { "compartment": "compartment_70101", "id": "reaction_10495919", "reactome": "R-DME-9008684", "name": "TBK1 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10455277" ], "products": [ "species_10495917", "species_29370" ], "modifiers": [], "additional_components": [ "FBgn0086657", "FBgn0086657" ] }, "reaction_10460539": { "compartment": "compartment_161320", "id": "reaction_10460539", "reactome": "R-DME-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605637", "species_1605601" ], "modifiers": [ [ "species_10460536", "catalyst" ] ], "additional_components": [ "Q7K127", "FBgn0034117", "Q9VL27", "FBgn0032192" ] }, "reaction_10460569": { "compartment": "compartment_876", "id": "reaction_10460569", "reactome": "R-DME-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10460566", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VZS6", "FBgn0035421" ] }, "reaction_10460472": { "compartment": "compartment_17938", "id": "reaction_10460472", "reactome": "R-DME-1605591", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605592" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10460469", "catalyst" ] ], "additional_components": [ "Q9Y125", "FBgn0000416", "Q8IMY3", "FBgn0051414" ] }, "reaction_10460822": { "compartment": "compartment_876", "id": "reaction_10460822", "reactome": "R-DME-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_113592" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10460819", "catalyst" ] ], "additional_components": [ "FBgn0037315" ] }, "reaction_10460591": { "compartment": "compartment_876", "id": "reaction_10460591", "reactome": "R-DME-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429807" ], "products": [ "species_1606609", "species_1861754" ], "modifiers": [ [ "species_10460588", "catalyst" ] ], "additional_components": [] }, "reaction_10460814": { "compartment": "compartment_20699", "id": "reaction_10460814", "reactome": "R-DME-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744227", "species_428270" ], "products": [ "species_1660674", "species_205687" ], "modifiers": [ [ "species_10460811", "catalyst" ] ], "additional_components": [ "FBgn0067102" ] }, "reaction_10461805": { "compartment": "compartment_70101", "id": "reaction_10461805", "reactome": "R-DME-1861789", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861764" ], "products": [ "species_194377", "species_70113" ], "modifiers": [ [ "species_10461802", "catalyst" ] ], "additional_components": [ "FBgn0036659" ] }, "reaction_10491828": { "compartment": "compartment_17963", "id": "reaction_10491828", "reactome": "R-DME-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_8879102" ], "products": [ "species_8879101", "species_205687" ], "modifiers": [ [ "species_10491825", "catalyst" ] ], "additional_components": [ "FBgn0000221" ] }, "reaction_10460522": { "compartment": "compartment_161320", "id": "reaction_10460522", "reactome": "R-DME-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605608" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10460519", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10471658": { "compartment": "compartment_70101", "id": "reaction_10471658", "reactome": "R-DME-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10471655", "catalyst" ] ], "additional_components": [ "FBgn0050392" ] }, "reaction_10461800": { "compartment": "compartment_876", "id": "reaction_10461800", "reactome": "R-DME-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861782" ], "products": [ "species_429807", "species_70113" ], "modifiers": [ [ "species_10461797", "catalyst" ] ], "additional_components": [ "FBgn0028916" ] }, "reaction_10460581": { "compartment": "compartment_161320", "id": "reaction_10460581", "reactome": "R-DME-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605637", "species_1605592" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_10460644": { "compartment": "compartment_17957", "id": "reaction_10460644", "reactome": "R-DME-1614362", "name": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194653", "species_10460622" ], "products": [ "species_10460641", "species_1663154", "species_194697" ], "modifiers": [ [ "species_10460596", "catalyst" ] ], "additional_components": [ "Q8SZ72", "FBgn0033763", "Q8IQS4", "FBgn0052191", "Q9VVM4", "FBgn0036768", "Q9VVM1", "FBgn0036765", "Q8SZ72", "FBgn0033763", "Q9VVM4", "FBgn0036768", "Q9VVM1", "FBgn0036765", "Q8IQS4", "FBgn0052191", "FBgn0035102" ] }, "reaction_10460547": { "compartment": "compartment_161320", "id": "reaction_10460547", "reactome": "R-DME-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10460544", "catalyst" ] ], "additional_components": [ "FBgn0034997" ] }, "reaction_10460579": { "compartment": "compartment_17957", "id": "reaction_10460579", "reactome": "R-DME-1606288", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_1606283" ], "products": [ "species_428256", "species_1606280" ], "modifiers": [ [ "species_10460576", "catalyst" ] ], "additional_components": [ "Q9VGH0", "FBgn0037958", "species_29926" ] }, "reaction_10471683": { "compartment": "compartment_876", "id": "reaction_10471683", "reactome": "R-DME-5340320", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340315" ], "products": [ "species_5340299" ], "modifiers": [ [ "species_10471680", "catalyst" ] ], "additional_components": [ "FBgn0030641" ] }, "reaction_10479745": { "compartment": "compartment_70101", "id": "reaction_10479745", "reactome": "R-DME-6785933", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452", "species_429807" ], "products": [ "species_6785915", "species_110096" ], "modifiers": [ [ "species_10479742", "catalyst" ] ], "additional_components": [ "FBgn0040257" ] }, "reaction_10460480": { "compartment": "compartment_161320", "id": "reaction_10460480", "reactome": "R-DME-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_209094": { "compartment": "compartment_70101", "id": "reaction_209094", "reactome": "R-DME-209094", "name": "Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex'", "reversible": "false", "notes": "The bound and phosphorylated Armadillo (ARM) is ubiquitated by the ubiquitin ligase assembled complex, whether this occurs when ARM is bound to the 'destruction complex' or after it has dissociated from it is unclear. The interaction between Slimb (SLMB) and ARM has weakened the latter's binding to the scaffolding molecules in the 'destruction complex'. ARM and the bound ubiquitin ligase assembled complex dissociate from Axin (AXN), APC (APC/APC2) and also from each other to leave free ubiquitinated and phosphorylated ARM which is now marked for degradation by the 26S proteasome.", "reactants": [ "species_206204", "species_207002" ], "products": [ "species_206991", "species_206602", "species_206788" ], "modifiers": [ [ "species_207002", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P18824", "arm", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209129": { "compartment": "compartment_70101", "id": "reaction_209129", "reactome": "R-DME-209129", "name": "Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex", "reversible": "false", "notes": "The free ubiquitinated and phosphorylated Armadillo (ARM) is now targeted by the 26S proteasome which binds and then degrades it. The cytoplasmic concentration of Armadillo is now reduced.", "reactants": [ "species_206991" ], "products": [ "species_206204" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "P18824", "arm", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_209102": { "compartment": "compartment_70101", "id": "reaction_209102", "reactome": "R-DME-209102", "name": "SLMB binds to phosphorylated ARM to form the 'destruction complex'", "reversible": "false", "notes": "The phosphorylated Armadillo (ARM) is now recognised and bound by the F-box protein Slimb (SLMB), in the E3 ubiquitin ligase assembled complex additionally containing the S-phase kinase-associated protein SKPA, the Cullin orthologue, LIN19, the Ring-box protein containg ROC1A, and the ubiquitin-conjugating enzyme orthologue EFF.", "reactants": [ "species_206788", "species_207028" ], "products": [ "species_207002" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_10459100": { "compartment": "compartment_7660", "id": "reaction_10459100", "reactome": "R-DME-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458007", "species_10459084" ], "products": [ "species_10459098" ], "modifiers": [], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q24472", "Rbf" ] }, "reaction_10458025": { "compartment": "compartment_7660", "id": "reaction_10458025", "reactome": "R-DME-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458009", "species_10457450" ], "products": [ "species_10458023" ], "modifiers": [], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q94517", "HDAC1", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10459096": { "compartment": "compartment_7660", "id": "reaction_10459096", "reactome": "R-DME-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458009", "species_10459084" ], "products": [ "species_10459094" ], "modifiers": [], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10458999": { "compartment": "compartment_7660", "id": "reaction_10458999", "reactome": "R-DME-1362261", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458995", "species_10457963" ], "products": [ "species_10458997" ], "modifiers": [], "additional_components": [ "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979" ] }, "reaction_10458021": { "compartment": "compartment_7660", "id": "reaction_10458021", "reactome": "R-DME-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457450", "species_10457963" ], "products": [ "species_10458019" ], "modifiers": [], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q94517", "HDAC1" ] }, "reaction_10459092": { "compartment": "compartment_7660", "id": "reaction_10459092", "reactome": "R-DME-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457947", "species_10459084" ], "products": [ "species_10459090" ], "modifiers": [], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9VF04", "FBgn0038390", "Q24472", "Rbf" ] }, "reaction_10459011": { "compartment": "compartment_7660", "id": "reaction_10459011", "reactome": "R-DME-1362270", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10459003" ], "products": [ "species_113582", "species_10458995" ], "modifiers": [ [ "species_10459008", "catalyst" ] ], "additional_components": [ "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979", "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979", "FBgn0259168" ] }, "reaction_10459088": { "compartment": "compartment_7660", "id": "reaction_10459088", "reactome": "R-DME-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457963", "species_10459084" ], "products": [ "species_10459086" ], "modifiers": [], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10439374": { "compartment": "compartment_13231", "id": "reaction_10439374", "reactome": "R-DME-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439372" ], "products": [ "species_10427755" ], "modifiers": [], "additional_components": [ "FBgn0010316", "FBgn0010316" ] }, "reaction_10439484": { "compartment": "compartment_7660", "id": "reaction_10439484", "reactome": "R-DME-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427716" ], "products": [ "species_113582", "species_10427482" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10440842": { "compartment": "compartment_70101", "id": "reaction_10440842", "reactome": "R-DME-198613", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439372" ], "products": [ "species_29370", "species_10440840" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0010316", "FBgn0010316" ] }, "reaction_10435622": { "compartment": "compartment_13231", "id": "reaction_10435622", "reactome": "R-DME-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427710" ], "products": [ "species_10427716" ], "modifiers": [], "additional_components": [ "P54733", "FBgn0010382", "P23573", "FBgn0004107", "P23573", "FBgn0004107" ] }, "reaction_10439404": { "compartment": "compartment_7660", "id": "reaction_10439404", "reactome": "R-DME-187575", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439395", "species_10427430" ], "products": [ "species_10439399" ], "modifiers": [ [ "species_10439395", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10439401": { "compartment": "compartment_7660", "id": "reaction_10439401", "reactome": "R-DME-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439399" ], "products": [ "species_10439393", "species_10427430", "species_10427484" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10439384": { "compartment": "compartment_7660", "id": "reaction_10439384", "reactome": "R-DME-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439376", "species_29358" ], "products": [ "species_113582", "species_10439381" ], "modifiers": [ [ "species_10439376", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316" ] }, "reaction_10439397": { "compartment": "compartment_7660", "id": "reaction_10439397", "reactome": "R-DME-187552", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439393", "species_10439381" ], "products": [ "species_10439395" ], "modifiers": [], "additional_components": [ "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10427729": { "compartment": "compartment_7660", "id": "reaction_10427729", "reactome": "R-DME-69195", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427716" ], "products": [ "species_113582", "species_10427721" ], "modifiers": [ [ "species_10427726", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "FBgn0011737" ] }, "reaction_10427712": { "compartment": "compartment_70101", "id": "reaction_10427712", "reactome": "R-DME-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427704", "species_10427706" ], "products": [ "species_10427710" ], "modifiers": [], "additional_components": [ "FBgn0004107", "FBgn0010382", "P54733", "FBgn0010382", "P23573", "FBgn0004107" ] }, "reaction_10427760": { "compartment": "compartment_7660", "id": "reaction_10427760", "reactome": "R-DME-69562", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427716", "species_10427755" ], "products": [ "species_10427757" ], "modifiers": [ [ "species_10427755", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "FBgn0010316", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "FBgn0010316" ] }, "reaction_10427744": { "compartment": "compartment_7660", "id": "reaction_10427744", "reactome": "R-DME-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10427721" ], "products": [ "species_113550", "species_10427716" ], "modifiers": [ [ "species_10427741", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P54733", "FBgn0010382", "P23573", "FBgn0004107", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10427470": { "compartment": "compartment_7660", "id": "reaction_10427470", "reactome": "R-DME-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68419", "species_10427294" ], "products": [ "species_10427296" ], "modifiers": [ [ "species_10427363", "catalyst" ] ], "additional_components": [ "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427372": { "compartment": "compartment_7660", "id": "reaction_10427372", "reactome": "R-DME-68918", "name": "CDK and DDK associate with the Mcm10:pre-replicative complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427348", "species_10427336", "species_10427357" ], "products": [ "species_10427359" ], "modifiers": [], "additional_components": [ "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "P23573", "FBgn0004107", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427468": { "compartment": "compartment_7660", "id": "reaction_10427468", "reactome": "R-DME-68954", "name": "Mcm2-7 is phosphorylated by DDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427244" ], "products": [ "species_113582", "species_10427465" ], "modifiers": [ [ "species_10427348", "catalyst" ] ], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "species_29372", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427370": { "compartment": "compartment_7660", "id": "reaction_10427370", "reactome": "R-DME-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427359", "species_10427327" ], "products": [ "species_10427361" ], "modifiers": [], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "FBgn0026143", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427368": { "compartment": "compartment_7660", "id": "reaction_10427368", "reactome": "R-DME-68916", "name": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427361", "species_10427322" ], "products": [ "species_10427363" ], "modifiers": [], "additional_components": [ "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427750": { "compartment": "compartment_7660", "id": "reaction_10427750", "reactome": "R-DME-69299", "name": "Cdt1 associates with geminin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427746", "species_10427208" ], "products": [ "species_10427748" ], "modifiers": [], "additional_components": [ "FBgn0033081", "FBgn0000996", "Q7JVY2", "FBgn0000996", "Q7JX41", "FBgn0033081" ] }, "reaction_10427365": { "compartment": "compartment_7660", "id": "reaction_10427365", "reactome": "R-DME-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427296", "species_10427272" ], "products": [ "species_10427298" ], "modifiers": [ [ "species_10427363", "catalyst" ] ], "additional_components": [ "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427378": { "compartment": "compartment_7660", "id": "reaction_10427378", "reactome": "R-DME-68940", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427374" ], "products": [ "species_10427208", "species_10427357" ], "modifiers": [], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "FBgn0000996", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929" ] }, "reaction_10427376": { "compartment": "compartment_7660", "id": "reaction_10427376", "reactome": "R-DME-68919", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427353", "species_10427246" ], "products": [ "species_10427374" ], "modifiers": [], "additional_components": [ "FBgn0032929", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929" ] }, "reaction_10493217": { "compartment": "compartment_70101", "id": "reaction_10493217", "reactome": "R-DME-8941895", "name": "Formation of CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487898", "species_10432397" ], "products": [ "species_10487900" ], "modifiers": [], "additional_components": [ "FBgn0010315", "FBgn0016131", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10493286": { "compartment": "compartment_13231", "id": "reaction_10493286", "reactome": "R-DME-8942803", "name": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493276" ], "products": [ "species_10493284" ], "modifiers": [], "additional_components": [ "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7JNL9", "FBgn0010316" ] }, "reaction_10493223": { "compartment": "compartment_70101", "id": "reaction_10493223", "reactome": "R-DME-8941915", "name": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487900", "species_10439372" ], "products": [ "species_10493221" ], "modifiers": [], "additional_components": [ "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "FBgn0010316", "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10459080": { "compartment": "compartment_7660", "id": "reaction_10459080", "reactome": "R-DME-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10457975" ], "products": [ "species_113550", "species_10457947" ], "modifiers": [ [ "species_10459075", "catalyst" ] ], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q9VF04", "FBgn0038390", "Q24472", "Rbf" ] }, "reaction_10493288": { "compartment": "compartment_7660", "id": "reaction_10493288", "reactome": "R-DME-8942836", "name": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10493284" ], "products": [ "species_113582", "species_10458002" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7JNL9", "FBgn0010316", "Q7JNL9", "FBgn0010316", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10459078": { "compartment": "compartment_7660", "id": "reaction_10459078", "reactome": "R-DME-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10458015" ], "products": [ "species_113550", "species_10458007" ], "modifiers": [ [ "species_10459075", "catalyst" ] ], "additional_components": [] }, "reaction_10493274": { "compartment": "compartment_70101", "id": "reaction_10493274", "reactome": "R-DME-8942607", "name": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10493221" ], "products": [ "species_29370", "species_10493251" ], "modifiers": [ [ "species_10493271", "catalyst" ] ], "additional_components": [ "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10458005": { "compartment": "compartment_7660", "id": "reaction_10458005", "reactome": "R-DME-1226094", "name": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10457963" ], "products": [ "species_113582", "species_10457975", "species_10457977" ], "modifiers": [ [ "species_10458002", "catalyst" ] ], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q7JNL9", "FBgn0010316", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10459109": { "compartment": "compartment_7660", "id": "reaction_10459109", "reactome": "R-DME-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10459102" ], "products": [ "species_10439393", "species_10459106" ], "modifiers": [ [ "species_10459102", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10458017": { "compartment": "compartment_7660", "id": "reaction_10458017", "reactome": "R-DME-1226095", "name": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10458009" ], "products": [ "species_113582", "species_10457977", "species_10458015" ], "modifiers": [ [ "species_10458002", "catalyst" ] ], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q7JNL9", "FBgn0010316", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10459104": { "compartment": "compartment_7660", "id": "reaction_10459104", "reactome": "R-DME-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439393", "species_10457975" ], "products": [ "species_10459102" ], "modifiers": [], "additional_components": [ "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10439450": { "compartment": "compartment_7660", "id": "reaction_10439450", "reactome": "R-DME-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426928", "species_10427405" ], "products": [ "species_10439448" ], "modifiers": [], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q27368", "phospho-E2f1" ] }, "reaction_10439464": { "compartment": "compartment_7660", "id": "reaction_10439464", "reactome": "R-DME-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10439448" ], "products": [ "species_113582", "species_10439461" ], "modifiers": [ [ "species_10439448", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "Q27368", "phospho-E2f1", "P23573", "FBgn0004107", "Q27368", "phospho-E2f1", "P23573", "FBgn0004107", "Q27368", "phospho-E2f1" ] }, "reaction_10437631": { "compartment": "compartment_13231", "id": "reaction_10437631", "reactome": "R-DME-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437595" ], "products": [ "species_10437575" ], "modifiers": [ [ "species_10437629", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "FBgn0020497" ] }, "reaction_10437726": { "compartment": "compartment_70101", "id": "reaction_10437726", "reactome": "R-DME-170161", "name": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10437719" ], "products": [ "species_29372", "species_10437723" ], "modifiers": [ [ "species_10437671", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437692": { "compartment": "compartment_13231", "id": "reaction_10437692", "reactome": "R-DME-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435511" ], "products": [ "species_10437690" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437659": { "compartment": "compartment_13231", "id": "reaction_10437659", "reactome": "R-DME-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437657" ], "products": [ "species_10437651" ], "modifiers": [], "additional_components": [ "P23572", "FBgn0004106", "P23572", "FBgn0004106" ] }, "reaction_10437624": { "compartment": "compartment_7660", "id": "reaction_10437624", "reactome": "R-DME-170070", "name": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437622" ], "products": [ "species_113582", "species_10437595" ], "modifiers": [ [ "species_10427726", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "FBgn0011737" ] }, "reaction_10437655": { "compartment": "compartment_7660", "id": "reaction_10437655", "reactome": "R-DME-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437651" ], "products": [ "species_113582", "species_10437653" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P23572", "FBgn0004106", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10437684": { "compartment": "compartment_13231", "id": "reaction_10437684", "reactome": "R-DME-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437583" ], "products": [ "species_10437601" ], "modifiers": [], "additional_components": [ "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10489387": { "compartment": "compartment_7660", "id": "reaction_10489387", "reactome": "R-DME-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10459075" ], "products": [ "species_77502", "species_10489379" ], "modifiers": [ [ "species_10489384", "catalyst" ] ], "additional_components": [ "FBgn0028507" ] }, "reaction_10437715": { "compartment": "compartment_13231", "id": "reaction_10437715", "reactome": "R-DME-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437713" ], "products": [ "species_10437696" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437618": { "compartment": "compartment_70101", "id": "reaction_10437618", "reactome": "R-DME-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437568", "species_10437609" ], "products": [ "species_10437611" ], "modifiers": [], "additional_components": [ "FBgn0000405", "FBgn0004106", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10437682": { "compartment": "compartment_70101", "id": "reaction_10437682", "reactome": "R-DME-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437675" ], "products": [ "species_29370", "species_10437583" ], "modifiers": [ [ "species_10437679", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P20439", "FBgn0000405", "P23572", "FBgn0004106" ] }, "reaction_10437649": { "compartment": "compartment_70101", "id": "reaction_10437649", "reactome": "R-DME-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437609", "species_10437645" ], "products": [ "species_10437647" ], "modifiers": [], "additional_components": [ "FBgn0004106", "P23572", "FBgn0004106" ] }, "reaction_10437616": { "compartment": "compartment_70101", "id": "reaction_10437616", "reactome": "R-DME-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437611" ], "products": [ "species_10437570", "species_29370" ], "modifiers": [ [ "species_10437613", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "FBgn0040298" ] }, "reaction_10489395": { "compartment": "compartment_7660", "id": "reaction_10489395", "reactome": "R-DME-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10489379" ], "products": [ "species_10459075", "species_8857797" ], "modifiers": [ [ "species_10489392", "catalyst" ] ], "additional_components": [ "FBgn0035951" ] }, "reaction_10437705": { "compartment": "compartment_7660", "id": "reaction_10437705", "reactome": "R-DME-170158", "name": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10437701" ], "products": [ "species_113550", "species_10437703" ], "modifiers": [ [ "species_10427741", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P23572", "FBgn0004106", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437673": { "compartment": "compartment_13231", "id": "reaction_10437673", "reactome": "R-DME-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437665" ], "products": [ "species_10437671" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437605": { "compartment": "compartment_13231", "id": "reaction_10437605", "reactome": "R-DME-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437585" ], "products": [ "species_10437603" ], "modifiers": [], "additional_components": [ "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10437635": { "compartment": "compartment_7660", "id": "reaction_10437635", "reactome": "R-DME-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437591" ], "products": [ "species_113582", "species_10437622" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10437699": { "compartment": "compartment_7660", "id": "reaction_10437699", "reactome": "R-DME-170153", "name": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10437595" ], "products": [ "species_113550", "species_10437694" ], "modifiers": [ [ "species_10437696", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10435532": { "compartment": "compartment_7660", "id": "reaction_10435532", "reactome": "R-DME-156699", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427726" ], "products": [ "species_113582", "species_10435530" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0011737", "FBgn0011737", "FBgn0003124" ] }, "reaction_10435516": { "compartment": "compartment_7660", "id": "reaction_10435516", "reactome": "R-DME-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10435503" ], "products": [ "species_29370", "species_10435511" ], "modifiers": [ [ "species_10435513", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0003124" ] }, "reaction_10435996": { "compartment": "compartment_7660", "id": "reaction_10435996", "reactome": "R-DME-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10435991" ], "products": [ "species_113582", "species_10435994" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0040298", "FBgn0040298", "FBgn0003124" ] }, "reaction_10488880": { "compartment": "compartment_70101", "id": "reaction_10488880", "reactome": "R-DME-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488823", "species_10426987" ], "products": [ "species_10488877" ], "modifiers": [ [ "species_10488823", "catalyst" ] ], "additional_components": [ "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147" ] }, "reaction_10488882": { "compartment": "compartment_70101", "id": "reaction_10488882", "reactome": "R-DME-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488877" ], "products": [ "species_10488821", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10488825": { "compartment": "compartment_70101", "id": "reaction_10488825", "reactome": "R-DME-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438226", "species_10488821" ], "products": [ "species_10488823" ], "modifiers": [], "additional_components": [ "FBgn0000147", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147" ] }, "reaction_10488890": { "compartment": "compartment_70101", "id": "reaction_10488890", "reactome": "R-DME-8854051", "name": "SCF-FBXL18 ubiquitinates FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456346", "species_10426987" ], "products": [ "species_10488885" ], "modifiers": [ [ "species_10488887", "catalyst" ] ], "additional_components": [ "FBgn0038385", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236" ] }, "reaction_10488892": { "compartment": "compartment_70101", "id": "reaction_10488892", "reactome": "R-DME-8854052", "name": "Formation of the SCF-FBXL7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442675", "species_10438327", "species_10438329", "species_10456346" ], "products": [ "species_10488821" ], "modifiers": [], "additional_components": [ "FBgn0038385", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10488894": { "compartment": "compartment_70101", "id": "reaction_10488894", "reactome": "R-DME-8854071", "name": "Proteasome-mediated degradation of PolyUb-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488885" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0038385", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10469628": { "compartment": "compartment_70101", "id": "reaction_10469628", "reactome": "R-DME-4086410", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469626" ], "products": [ "species_29370", "species_10467358" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "FBgn0259791", "FBgn0259791", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10467367": { "compartment": "compartment_70101", "id": "reaction_10467367", "reactome": "R-DME-3000327", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467360", "species_113592" ], "products": [ "species_10467364", "species_29370", "species_10435513" ], "modifiers": [ [ "species_10467360", "catalyst" ] ], "additional_components": [ "Q9VVR2", "FBgn0259791", "P52304", "FBgn0003124", "FBgn0259791", "FBgn0003124", "Q9VVR2", "FBgn0259791", "P52304", "FBgn0003124" ] }, "reaction_10467399": { "compartment": "compartment_7660", "id": "reaction_10467399", "reactome": "R-DME-3002811", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10435494" ], "products": [ "species_113550", "species_10467382" ], "modifiers": [ [ "species_10467396", "catalyst" ] ], "additional_components": [ "FBgn0003124", "FBgn0003124", "M9NEB2", "FBgn0005536", "P48462", "flw" ] }, "reaction_10467380": { "compartment": "compartment_70101", "id": "reaction_10467380", "reactome": "R-DME-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435513" ], "products": [ "species_10435494" ], "modifiers": [], "additional_components": [ "FBgn0003124", "FBgn0003124" ] }, "reaction_10427303": { "compartment": "compartment_7660", "id": "reaction_10427303", "reactome": "R-DME-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427298", "species_30595" ], "products": [ "species_10427300", "species_10427294" ], "modifiers": [ [ "species_10427298", "catalyst" ] ], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "species_110577", "species_113592", "species_29494", "species_29438", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644" ] }, "reaction_10427463": { "compartment": "compartment_7660", "id": "reaction_10427463", "reactome": "R-DME-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427300", "species_30187", "species_30185", "species_29892", "species_29604" ], "products": [ "species_10427460" ], "modifiers": [ [ "species_10427272", "catalyst" ] ], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113" ] }, "reaction_10427595": { "compartment": "compartment_7660", "id": "reaction_10427595", "reactome": "R-DME-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427244" ], "products": [ "species_10427217", "species_10427593", "species_10427242", "species_10427227" ], "modifiers": [], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "FBgn0284442", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9V461", "FBgn0025815", "FBgn0014861", "FBgn0017577" ] }, "reaction_10427452": { "compartment": "compartment_7660", "id": "reaction_10427452", "reactome": "R-DME-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10427382" ], "products": [ "species_10427433" ], "modifiers": [ [ "species_10427449", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0286788", "FBgn0286788", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1" ] }, "reaction_10427458": { "compartment": "compartment_70101", "id": "reaction_10427458", "reactome": "R-DME-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427454" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0286788", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10427408": { "compartment": "compartment_7660", "id": "reaction_10427408", "reactome": "R-DME-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427246" ], "products": [ "species_113582", "species_10427382", "species_10427384" ], "modifiers": [ [ "species_10427405", "catalyst" ] ], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "FBgn0286788", "Q9VSM9", "FBgn0035918", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q7JVY2", "FBgn0000996", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "P23573", "FBgn0004107" ] }, "reaction_10427456": { "compartment": "compartment_7660", "id": "reaction_10427456", "reactome": "R-DME-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427433" ], "products": [ "species_10427454" ], "modifiers": [], "additional_components": [ "FBgn0286788", "FBgn0286788" ] }, "reaction_10427487": { "compartment": "compartment_7660", "id": "reaction_10427487", "reactome": "R-DME-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10426924" ], "products": [ "species_113582", "species_10427473" ], "modifiers": [ [ "species_10427484", "catalyst" ] ], "additional_components": [ "FBgn0035918", "FBgn0035918", "P23573", "FBgn0004107", "P54733", "FBgn0010382" ] }, "reaction_10427591": { "compartment": "compartment_70101", "id": "reaction_10427591", "reactome": "R-DME-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427495" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSM9", "FBgn0035918", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10427589": { "compartment": "compartment_70101", "id": "reaction_10427589", "reactome": "R-DME-69015", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427489", "species_113592", "species_10426987" ], "products": [ "species_10427495" ], "modifiers": [ [ "species_10427586", "catalyst" ] ], "additional_components": [ "FBgn0035918", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSM9", "FBgn0035918", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699" ] }, "reaction_10427491": { "compartment": "compartment_7660", "id": "reaction_10427491", "reactome": "R-DME-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427473" ], "products": [ "species_10427489" ], "modifiers": [], "additional_components": [ "FBgn0035918", "FBgn0035918" ] }, "reaction_10427694": { "compartment": "compartment_7660", "id": "reaction_10427694", "reactome": "R-DME-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427682" ], "products": [ "species_10427686" ], "modifiers": [ [ "species_10427691", "catalyst" ] ], "additional_components": [ "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "FBgn0025832" ] }, "reaction_10427671": { "compartment": "compartment_7660", "id": "reaction_10427671", "reactome": "R-DME-69140", "name": "RPA binds to the Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_10427663" ], "products": [ "species_10427669" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10427684": { "compartment": "compartment_7660", "id": "reaction_10427684", "reactome": "R-DME-69144", "name": "Removal of RNA primer and dissociation of RPA and Dna2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427678" ], "products": [ "species_418075", "species_10427682", "species_10427667", "species_164121", "species_29626", "species_418076", "species_10427676" ], "modifiers": [], "additional_components": [ "Q8IRL9", "FBgn0030170", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0030170" ] }, "reaction_10427680": { "compartment": "compartment_7660", "id": "reaction_10427680", "reactome": "R-DME-69142", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427669", "species_10427676" ], "products": [ "species_10427678" ], "modifiers": [], "additional_components": [ "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0030170", "Q8IRL9", "FBgn0030170", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10427702": { "compartment": "compartment_7660", "id": "reaction_10427702", "reactome": "R-DME-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10427699", "catalyst" ] ], "additional_components": [ "FBgn0262619" ] }, "reaction_10427665": { "compartment": "compartment_7660", "id": "reaction_10427665", "reactome": "R-DME-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427661" ], "products": [ "species_10427663" ], "modifiers": [], "additional_components": [ "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655" ] }, "reaction_10427626": { "compartment": "compartment_7660", "id": "reaction_10427626", "reactome": "R-DME-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427460", "species_10427622" ], "products": [ "species_10427624" ], "modifiers": [], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113" ] }, "reaction_10427641": { "compartment": "compartment_7660", "id": "reaction_10427641", "reactome": "R-DME-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427635" ], "products": [ "species_10427622", "species_10427639" ], "modifiers": [], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655" ] }, "reaction_10427637": { "compartment": "compartment_7660", "id": "reaction_10427637", "reactome": "R-DME-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427633", "species_10427624" ], "products": [ "species_113582", "species_10427635" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655" ] }, "reaction_10438762": { "compartment": "compartment_7660", "id": "reaction_10438762", "reactome": "R-DME-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438753", "species_10438758", "species_10438743", "species_10438748" ], "products": [ "species_10438760" ], "modifiers": [], "additional_components": [ "FBgn0030196", "FBgn0039403", "FBgn0035194", "FBgn0261976", "Q9VQY9", "FBgn0261976", "Q9W0I7", "FBgn0035194", "Q9VBI1", "FBgn0039403", "Q9W2V7", "FBgn0030196" ] }, "reaction_10438063": { "compartment": "compartment_70101", "id": "reaction_10438063", "reactome": "R-DME-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427704", "species_10437645" ], "products": [ "species_10438061" ], "modifiers": [], "additional_components": [ "FBgn0004107", "P23573", "FBgn0004107" ] }, "reaction_10439454": { "compartment": "compartment_7660", "id": "reaction_10439454", "reactome": "R-DME-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438267" ], "products": [ "species_113582", "species_10427405" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10439452": { "compartment": "compartment_7660", "id": "reaction_10439452", "reactome": "R-DME-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438212" ], "products": [ "species_113582", "species_10438066" ], "modifiers": [ [ "species_10427405", "catalyst" ] ], "additional_components": [ "FBgn0262699", "FBgn0262699", "P23573", "FBgn0004107" ] }, "reaction_10439446": { "compartment": "compartment_7660", "id": "reaction_10439446", "reactome": "R-DME-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427755", "species_10438267" ], "products": [ "species_10439439" ], "modifiers": [ [ "species_10427755", "catalyst" ] ], "additional_components": [ "FBgn0010316", "P23573", "FBgn0004107", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "FBgn0010316" ] }, "reaction_10439444": { "compartment": "compartment_7660", "id": "reaction_10439444", "reactome": "R-DME-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10439439" ], "products": [ "species_113582", "species_10439441" ], "modifiers": [ [ "species_10439439", "catalyst" ] ], "additional_components": [ "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q7JNL9", "FBgn0010316", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107" ] }, "reaction_10438353": { "compartment": "compartment_7660", "id": "reaction_10438353", "reactome": "R-DME-174164", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438267" ], "products": [ "species_113582", "species_10438265" ], "modifiers": [ [ "species_10427726", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "FBgn0011737" ] }, "reaction_10438384": { "compartment": "compartment_13231", "id": "reaction_10438384", "reactome": "R-DME-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438061" ], "products": [ "species_10438267" ], "modifiers": [], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107" ] }, "reaction_10438272": { "compartment": "compartment_7660", "id": "reaction_10438272", "reactome": "R-DME-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10438265" ], "products": [ "species_113550", "species_10438267" ], "modifiers": [ [ "species_10438269", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10432407": { "compartment": "compartment_70101", "id": "reaction_10432407", "reactome": "R-DME-75825", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432405" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7KUZ5", "FBgn0010315", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10432403": { "compartment": "compartment_13231", "id": "reaction_10432403", "reactome": "R-DME-75823", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432386" ], "products": [ "species_10432395" ], "modifiers": [], "additional_components": [ "FBgn0010315", "FBgn0010315" ] }, "reaction_10432401": { "compartment": "compartment_13231", "id": "reaction_10432401", "reactome": "R-DME-75822", "name": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432393" ], "products": [ "species_10432399" ], "modifiers": [], "additional_components": [ "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10466073": { "compartment": "compartment_7660", "id": "reaction_10466073", "reactome": "R-DME-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466069", "species_113560" ], "products": [ "species_2485002", "species_10466071" ], "modifiers": [ [ "species_10466031", "catalyst" ] ], "additional_components": [ "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9VXE9", "FBgn0015615", "FBgn0035766" ] }, "reaction_10466036": { "compartment": "compartment_7660", "id": "reaction_10466036", "reactome": "R-DME-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466018", "species_113560" ], "products": [ "species_2485002", "species_10466026" ], "modifiers": [ [ "species_10466031", "catalyst" ] ], "additional_components": [ "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9VXE9", "FBgn0015615", "FBgn0035766" ] }, "reaction_10498336": { "compartment": "compartment_70101", "id": "reaction_10498336", "reactome": "R-DME-9656947", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498332" ], "products": [ "species_10498334" ], "modifiers": [], "additional_components": [ "FBgn0027864", "FBgn0027864" ] }, "reaction_10497794": { "compartment": "compartment_7660", "id": "reaction_10497794", "reactome": "R-DME-9629492", "name": "NEIL3 cleaves spiroiminodihydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497791" ], "products": [ "species_9629439", "species_10497784" ], "modifiers": [ [ "species_10497791", "catalyst" ] ], "additional_components": [ "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258" ] }, "reaction_10433945": { "compartment": "compartment_7660", "id": "reaction_10433945", "reactome": "R-DME-110243", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433940" ], "products": [ "species_10433942", "species_110242" ], "modifiers": [ [ "species_10433940", "catalyst" ] ], "additional_components": [ "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864" ] }, "reaction_10497787": { "compartment": "compartment_7660", "id": "reaction_10497787", "reactome": "R-DME-9629470", "name": "NEIL3 cleaves 5-guanidinohydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497782" ], "products": [ "species_10497784", "species_9629218" ], "modifiers": [ [ "species_10497782", "catalyst" ] ], "additional_components": [ "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258" ] }, "reaction_10433903": { "compartment": "compartment_7660", "id": "reaction_10433903", "reactome": "R-DME-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433898" ], "products": [ "species_110223", "species_10433900" ], "modifiers": [ [ "species_10433898", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10433950": { "compartment": "compartment_7660", "id": "reaction_10433950", "reactome": "R-DME-110244", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433947" ], "products": [ "species_10433942", "species_5636006" ], "modifiers": [ [ "species_10433947", "catalyst" ] ], "additional_components": [ "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864" ] }, "reaction_10433917": { "compartment": "compartment_7660", "id": "reaction_10433917", "reactome": "R-DME-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433914" ], "products": [ "species_30140", "species_10433900" ], "modifiers": [ [ "species_10433914", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10433883": { "compartment": "compartment_7660", "id": "reaction_10433883", "reactome": "R-DME-110219", "name": "Cleavage of thymine by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433880" ], "products": [ "species_10433873", "species_29692" ], "modifiers": [ [ "species_10433880", "catalyst" ] ], "additional_components": [ "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869" ] }, "reaction_10433931": { "compartment": "compartment_7660", "id": "reaction_10433931", "reactome": "R-DME-110234", "name": "Cleavage of ethenocytosine by TDG glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433928" ], "products": [ "species_10433873", "species_110233" ], "modifiers": [ [ "species_10433928", "catalyst" ] ], "additional_components": [ "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869" ] }, "reaction_10433894": { "compartment": "compartment_7660", "id": "reaction_10433894", "reactome": "R-DME-110221", "name": "Cleavage of uracil by SMUG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433887" ], "products": [ "species_10433891", "species_29554" ], "modifiers": [ [ "species_10433887", "catalyst" ] ], "additional_components": [ "Q9VEM1", "FBgn0038490", "Q9VEM1", "FBgn0038490", "Q9VEM1", "FBgn0038490" ] }, "reaction_10433910": { "compartment": "compartment_7660", "id": "reaction_10433910", "reactome": "R-DME-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433907" ], "products": [ "species_10433900", "species_110225" ], "modifiers": [ [ "species_10433907", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10433876": { "compartment": "compartment_7660", "id": "reaction_10433876", "reactome": "R-DME-110218", "name": "Cleavage of uracil by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433869" ], "products": [ "species_10433873", "species_29554" ], "modifiers": [ [ "species_10433869", "catalyst" ] ], "additional_components": [ "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869" ] }, "reaction_10433924": { "compartment": "compartment_7660", "id": "reaction_10433924", "reactome": "R-DME-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433921" ], "products": [ "species_5637659", "species_10433900" ], "modifiers": [ [ "species_10433921", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10474548": { "compartment": "compartment_7660", "id": "reaction_10474548", "reactome": "R-DME-5649681", "name": "NEIL2 cleaves 5-OHU from damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474543" ], "products": [ "species_10474545", "species_110216" ], "modifiers": [ [ "species_10474543", "catalyst" ] ], "additional_components": [ "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258" ] }, "reaction_10434063": { "compartment": "compartment_7660", "id": "reaction_10434063", "reactome": "R-DME-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434046" ], "products": [ "species_10434060" ], "modifiers": [ [ "species_10434046", "catalyst" ] ], "additional_components": [ "P27864", "FBgn0004584", "P27864", "FBgn0004584", "P27864", "FBgn0004584" ] }, "reaction_10434056": { "compartment": "compartment_7660", "id": "reaction_10434056", "reactome": "R-DME-110354", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433942", "species_10434044" ], "products": [ "species_10433936", "species_10434046" ], "modifiers": [], "additional_components": [ "Q9V3I8", "FBgn0027864", "FBgn0004584", "FBgn0027864", "P27864", "FBgn0004584" ] }, "reaction_10434054": { "compartment": "compartment_7660", "id": "reaction_10434054", "reactome": "R-DME-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433900", "species_10434044" ], "products": [ "species_10433865", "species_10434046" ], "modifiers": [], "additional_components": [ "Q9VIH0", "FBgn0032907", "FBgn0004584", "FBgn0032907", "P27864", "FBgn0004584" ] }, "reaction_10434052": { "compartment": "compartment_7660", "id": "reaction_10434052", "reactome": "R-DME-110351", "name": "Displacement of SMUG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434050", "species_10434044" ], "products": [ "species_10433860", "species_10434046" ], "modifiers": [], "additional_components": [ "Q9VEM1", "FBgn0038490", "FBgn0004584", "FBgn0038490", "P27864", "FBgn0004584" ] }, "reaction_10434048": { "compartment": "compartment_7660", "id": "reaction_10434048", "reactome": "R-DME-110350", "name": "Displacement of TDG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433873", "species_10434044" ], "products": [ "species_10434046", "species_10433855" ], "modifiers": [], "additional_components": [ "Q9V4D8", "FBgn0026869", "FBgn0004584", "P27864", "FBgn0004584", "FBgn0026869" ] }, "reaction_10474554": { "compartment": "compartment_7660", "id": "reaction_10474554", "reactome": "R-DME-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434060" ], "products": [ "species_10474552" ], "modifiers": [], "additional_components": [ "P27864", "FBgn0004584", "P27864", "FBgn0004584" ] }, "reaction_10434078": { "compartment": "compartment_7660", "id": "reaction_10434078", "reactome": "R-DME-110368", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10434075" ], "products": [ "species_10434071", "species_113541" ], "modifiers": [ [ "species_10434075", "catalyst" ] ], "additional_components": [ "P27864", "FBgn0004584", "Q7K7A9", "FBgn0025832", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P27864", "FBgn0004584", "Q7K7A9", "FBgn0025832", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P27864", "FBgn0004584", "Q7K7A9", "FBgn0025832", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10434086": { "compartment": "compartment_7660", "id": "reaction_10434086", "reactome": "R-DME-110371", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434082", "species_10427699" ], "products": [ "species_10434084" ], "modifiers": [], "additional_components": [ "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "FBgn0262619", "Q9W1H4", "FBgn0262619", "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10474561": { "compartment": "compartment_7660", "id": "reaction_10474561", "reactome": "R-DME-5651805", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434084" ], "products": [ "species_10474558" ], "modifiers": [ [ "species_10434084", "catalyst" ] ], "additional_components": [ "Q9W1H4", "FBgn0262619", "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P27864", "FBgn0004584", "Q9W1H4", "FBgn0262619", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q9W1H4", "FBgn0262619", "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10432365": { "compartment": "compartment_7660", "id": "reaction_10432365", "reactome": "R-DME-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432356", "species_10432361" ], "products": [ "species_10432363" ], "modifiers": [], "additional_components": [ "FBgn0034728", "FBgn0020270", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728" ] }, "reaction_10468909": { "compartment": "compartment_7660", "id": "reaction_10468909", "reactome": "R-DME-3785768", "name": "MRN complex binds DNA double strand breaks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75165", "species_10432372" ], "products": [ "species_10468907" ], "modifiers": [], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476443": { "compartment": "compartment_70101", "id": "reaction_10476443", "reactome": "R-DME-5684008", "name": "NBN binds KPNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476433", "species_10476435" ], "products": [ "species_10476437" ], "modifiers": [], "additional_components": [ "FBgn0267727", "FBgn0261530", "Q9VT40", "FBgn0261530", "P52295", "FBgn0267727" ] }, "reaction_10476441": { "compartment": "compartment_7660", "id": "reaction_10476441", "reactome": "R-DME-5684006", "name": "KPNA2 translocates NBN to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476437" ], "products": [ "species_10432370", "species_10476439" ], "modifiers": [], "additional_components": [ "Q9VT40", "FBgn0261530", "P52295", "FBgn0267727", "FBgn0261530", "FBgn0267727" ] }, "reaction_10432374": { "compartment": "compartment_7660", "id": "reaction_10432374", "reactome": "R-DME-75174", "name": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432370", "species_10432363" ], "products": [ "species_10432372" ], "modifiers": [], "additional_components": [ "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476320": { "compartment": "compartment_7660", "id": "reaction_10476320", "reactome": "R-DME-5682044", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10476315" ], "products": [ "species_2485002", "species_10476317" ], "modifiers": [ [ "species_10476315", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080" ] }, "reaction_10476396": { "compartment": "compartment_7660", "id": "reaction_10476396", "reactome": "R-DME-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10476391" ], "products": [ "species_113582", "species_10427797" ], "modifiers": [ [ "species_10476391", "catalyst" ] ], "additional_components": [ "O61267", "FBgn0019686", "FBgn0019686", "O61267", "FBgn0019686" ] }, "reaction_10476393": { "compartment": "compartment_7660", "id": "reaction_10476393", "reactome": "R-DME-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476389" ], "products": [ "species_10476391" ], "modifiers": [], "additional_components": [ "FBgn0019686", "O61267", "FBgn0019686" ] }, "reaction_10478112": { "compartment": "compartment_7660", "id": "reaction_10478112", "reactome": "R-DME-5693598", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10478100" ], "products": [ "species_113582", "species_10476458" ], "modifiers": [ [ "species_10478100", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080" ] }, "reaction_10476764": { "compartment": "compartment_7660", "id": "reaction_10476764", "reactome": "R-DME-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10476754" ], "products": [ "species_68454", "species_10476761", "species_10427691" ], "modifiers": [ [ "species_10476754", "catalyst" ] ], "additional_components": [ "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "FBgn0025832", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476728": { "compartment": "compartment_7660", "id": "reaction_10476728", "reactome": "R-DME-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10476721" ], "products": [ "species_30555", "species_10476725" ], "modifiers": [ [ "species_10476721", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476743": { "compartment": "compartment_7660", "id": "reaction_10476743", "reactome": "R-DME-5687484", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476725", "species_10474568", "species_10427691", "species_10476735" ], "products": [ "species_10476741" ], "modifiers": [], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "FBgn0025832", "O18475", "FBgn0002905", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "P35875", "FBgn0010247", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476757": { "compartment": "compartment_7660", "id": "reaction_10476757", "reactome": "R-DME-5687653", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10476749" ], "products": [ "species_427497", "species_10476754", "species_10474566", "species_10476735" ], "modifiers": [ [ "species_10476749", "catalyst" ] ], "additional_components": [ "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "O18475", "FBgn0002905", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247" ] }, "reaction_10476752": { "compartment": "compartment_7660", "id": "reaction_10476752", "reactome": "R-DME-5687640", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10476741" ], "products": [ "species_113541", "species_10476749" ], "modifiers": [ [ "species_10476741", "catalyst" ] ], "additional_components": [ "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "P35875", "FBgn0010247", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "P35875", "FBgn0010247", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476768": { "compartment": "compartment_7660", "id": "reaction_10476768", "reactome": "R-DME-5687673", "name": "MRN recruits LIG3:XRCC1 to MMEJ sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434098", "species_10476761" ], "products": [ "species_10476766" ], "modifiers": [], "additional_components": [ "Q9Y095", "FBgn0026751", "Q9VG84", "FBgn0286075", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9Y095", "FBgn0026751", "Q9VG84", "FBgn0286075" ] }, "reaction_10476783": { "compartment": "compartment_7660", "id": "reaction_10476783", "reactome": "R-DME-5687758", "name": "PPP4C:PPP4R2 dephosphorylates RPA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10476563" ], "products": [ "species_113550", "species_10427667" ], "modifiers": [ [ "species_10476780", "catalyst" ] ], "additional_components": [ "Q24492", "FBgn0010173", "Q9VYW3", "FBgn0266421", "Q9VIH1", "FBgn0032906", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W2U4", "FBgn0030208", "O76932", "FBgn0023177" ] }, "reaction_10476631": { "compartment": "compartment_7660", "id": "reaction_10476631", "reactome": "R-DME-5686430", "name": "MUS81 binds EME1, EME2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476616", "species_10476623" ], "products": [ "species_10476629" ], "modifiers": [], "additional_components": [ "FBgn0033549", "FBgn0040347", "Q9V3T1", "FBgn0040347", "A1Z8C0", "FBgn0033549" ] }, "reaction_10476647": { "compartment": "compartment_7660", "id": "reaction_10476647", "reactome": "R-DME-5686475", "name": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476643", "species_10476629" ], "products": [ "species_10476645" ], "modifiers": [], "additional_components": [ "Q9VN41", "FBgn0037263", "Q9VS48", "FBgn0002909", "Q9V3T1", "FBgn0040347", "A1Z8C0", "FBgn0033549", "Q9V3T1", "FBgn0040347", "A1Z8C0", "FBgn0033549", "Q9VN41", "FBgn0037263", "Q9VS48", "FBgn0002909" ] }, "reaction_10476597": { "compartment": "compartment_7660", "id": "reaction_10476597", "reactome": "R-DME-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476592", "species_29358" ], "products": [ "species_113582", "species_10476595" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "FBgn0003479", "FBgn0003479", "FBgn0261278" ] }, "reaction_10479290": { "compartment": "compartment_7660", "id": "reaction_10479290", "reactome": "R-DME-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479283", "species_6781829" ], "products": [ "species_10479287", "species_113541" ], "modifiers": [ [ "species_10479283", "catalyst" ] ], "additional_components": [ "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10479322": { "compartment": "compartment_7660", "id": "reaction_10479322", "reactome": "R-DME-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479302", "species_10427430" ], "products": [ "species_10479319" ], "modifiers": [ [ "species_10479302", "catalyst" ] ], "additional_components": [ "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962" ] }, "reaction_10479304": { "compartment": "compartment_7660", "id": "reaction_10479304", "reactome": "R-DME-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479300", "species_10479294" ], "products": [ "species_10479302", "species_10477930" ], "modifiers": [], "additional_components": [ "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057" ] }, "reaction_10479285": { "compartment": "compartment_7660", "id": "reaction_10479285", "reactome": "R-DME-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431174", "species_10429254", "species_5688114" ], "products": [ "species_10479283" ], "modifiers": [], "additional_components": [ "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10479365": { "compartment": "compartment_7660", "id": "reaction_10479365", "reactome": "R-DME-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479356" ], "products": [ "species_10479362", "species_10427430" ], "modifiers": [ [ "species_10479356", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366" ] }, "reaction_10479390": { "compartment": "compartment_7660", "id": "reaction_10479390", "reactome": "R-DME-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433815", "species_10479386" ], "products": [ "species_10479388" ], "modifiers": [], "additional_components": [ "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10479406": { "compartment": "compartment_7660", "id": "reaction_10479406", "reactome": "R-DME-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479388" ], "products": [ "species_10479392" ], "modifiers": [ [ "species_10479388", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P20232", "FBgn0010422", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P28518", "FBgn0004832", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10479376": { "compartment": "compartment_7660", "id": "reaction_10479376", "reactome": "R-DME-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10479362" ], "products": [ "species_113550", "species_113582", "species_10479373" ], "modifiers": [ [ "species_10479362", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962" ] }, "reaction_10479402": { "compartment": "compartment_7660", "id": "reaction_10479402", "reactome": "R-DME-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10479397" ], "products": [ "species_10479399", "species_113541" ], "modifiers": [ [ "species_10479397", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366" ] }, "reaction_10479413": { "compartment": "compartment_7660", "id": "reaction_10479413", "reactome": "R-DME-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479399" ], "products": [ "species_10479408", "species_10477658" ], "modifiers": [ [ "species_10479410", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W1H4", "FBgn0262619", "Q9Y095", "FBgn0026751", "Q9VG84", "FBgn0286075" ] }, "reaction_10477876": { "compartment": "compartment_7660", "id": "reaction_10477876", "reactome": "R-DME-5691001", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477873", "species_30555" ], "products": [ "species_113541", "species_10477869" ], "modifiers": [ [ "species_10477873", "catalyst" ] ], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10479228": { "compartment": "compartment_7660", "id": "reaction_10479228", "reactome": "R-DME-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479224", "species_427523" ], "products": [ "species_427497", "species_10477240" ], "modifiers": [], "additional_components": [ "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698" ] }, "reaction_10477880": { "compartment": "compartment_7660", "id": "reaction_10477880", "reactome": "R-DME-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477878", "species_5688114", "species_10477932" ], "products": [ "species_10477930", "species_10477934" ], "modifiers": [ [ "species_10477169", "catalyst" ] ], "additional_components": [ "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "Q24595", "FBgn0004698", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "Q24595", "FBgn0004698", "Q7K012", "FBgn0025716", "Q9Y0Z1", "FBgn0027503", "Q8ST83", "FBgn0002521", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "Q9W3D4", "FBgn0040929", "Q9VH07", "FBgn0040078", "A1Z6E8", "FBgn0033019", "A1Z8D5", "FBgn0033566", "Q9VX09", "FBgn0030877", "Q9VFH4", "FBgn0086686", "Q9VEC3", "FBgn0038576", "Q4V604", "FBgn0052202", "Q9VDY1", "FBgn0086613", "Q9VZJ3", "FBgn0263832" ] }, "reaction_10477871": { "compartment": "compartment_7660", "id": "reaction_10477871", "reactome": "R-DME-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431174", "species_10477240" ], "products": [ "species_10477242" ], "modifiers": [], "additional_components": [ "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10477865": { "compartment": "compartment_7660", "id": "reaction_10477865", "reactome": "R-DME-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10477858" ], "products": [ "species_113550", "species_113582", "species_10477862" ], "modifiers": [ [ "species_10477858", "catalyst" ] ], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P28518", "FBgn0004832", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P28518", "FBgn0004832" ] }, "reaction_10433817": { "compartment": "compartment_7660", "id": "reaction_10433817", "reactome": "R-DME-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433808", "species_10433813" ], "products": [ "species_10433815" ], "modifiers": [], "additional_components": [ "FBgn0028434", "FBgn0002707", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10480324": { "compartment": "compartment_7660", "id": "reaction_10480324", "reactome": "R-DME-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480310", "species_10477862" ], "products": [ "species_10467222", "species_10480319" ], "modifiers": [ [ "species_10480321", "catalyst" ] ], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "FBgn0010602", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q24595", "FBgn0004698", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O97102", "FBgn0264922", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832" ] }, "reaction_10477248": { "compartment": "compartment_7660", "id": "reaction_10477248", "reactome": "R-DME-5689861", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477221", "species_10477242" ], "products": [ "species_10431137", "species_10477246" ], "modifiers": [], "additional_components": [ "FBgn0004832", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P28518", "FBgn0004832" ] }, "reaction_10477856": { "compartment": "compartment_7660", "id": "reaction_10477856", "reactome": "R-DME-5690991", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433815", "species_10477849" ], "products": [ "species_10477851" ], "modifiers": [], "additional_components": [ "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10477854": { "compartment": "compartment_7660", "id": "reaction_10477854", "reactome": "R-DME-5690990", "name": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477851" ], "products": [ "species_10477652" ], "modifiers": [ [ "species_10477851", "catalyst" ] ], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10477662": { "compartment": "compartment_7660", "id": "reaction_10477662", "reactome": "R-DME-5690213", "name": "DNA polymerases delta, epsilon or kappa bind the GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434065", "species_10477652", "species_10477654", "species_10427622" ], "products": [ "species_10477660" ], "modifiers": [], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P35875", "FBgn0010247", "P28518", "FBgn0004832" ] }, "reaction_10475262": { "compartment": "compartment_7660", "id": "reaction_10475262", "reactome": "R-DME-5655466", "name": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475257" ], "products": [ "species_10427430", "species_10475255", "species_10475259" ], "modifiers": [ [ "species_10475257", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476" ] }, "reaction_10474603": { "compartment": "compartment_7660", "id": "reaction_10474603", "reactome": "R-DME-5652005", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474580", "species_10474599" ], "products": [ "species_10474601" ], "modifiers": [], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10475271": { "compartment": "compartment_7660", "id": "reaction_10475271", "reactome": "R-DME-5655483", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475255" ], "products": [ "species_10475266", "species_10475268", "species_10475253" ], "modifiers": [ [ "species_10475255", "catalyst" ] ], "additional_components": [ "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "FBgn0028476", "FBgn0028476", "FBgn0033607", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476" ] }, "reaction_10474608": { "compartment": "compartment_7660", "id": "reaction_10474608", "reactome": "R-DME-5652009", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10474601" ], "products": [ "species_10434065", "species_10474599", "species_10474605" ], "modifiers": [ [ "species_10474601", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10475264": { "compartment": "compartment_7660", "id": "reaction_10475264", "reactome": "R-DME-5655481", "name": "USP1:WDR48 binds monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475255", "species_10474605" ], "products": [ "species_10475257" ], "modifiers": [], "additional_components": [ "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476" ] }, "reaction_10475290": { "compartment": "compartment_7660", "id": "reaction_10475290", "reactome": "R-DME-5655892", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475281", "species_30555" ], "products": [ "species_10475287", "species_113541" ], "modifiers": [ [ "species_10475281", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150" ] }, "reaction_10475299": { "compartment": "compartment_7660", "id": "reaction_10475299", "reactome": "R-DME-5655965", "name": "POLK and POLZ cooperate in elongation of mispaired primer termini", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10475287" ], "products": [ "species_10475296", "species_10433955", "species_10433993", "species_113541" ], "modifiers": [ [ "species_10475287", "catalyst" ] ], "additional_components": [ "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "species_266099", "species_29926", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150" ] }, "reaction_10433981": { "compartment": "compartment_7660", "id": "reaction_10433981", "reactome": "R-DME-110308", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433970", "species_30185" ], "products": [ "species_10433978" ], "modifiers": [ [ "species_10433970", "catalyst" ] ], "additional_components": [ "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10434039": { "compartment": "compartment_7660", "id": "reaction_10434039", "reactome": "R-DME-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433986", "species_10433991" ], "products": [ "species_10433993" ], "modifiers": [], "additional_components": [ "FBgn0002891", "FBgn0037345", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891" ] }, "reaction_10433972": { "compartment": "compartment_7660", "id": "reaction_10433972", "reactome": "R-DME-110307", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433968", "species_10433955" ], "products": [ "species_10433970" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0035150", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10474610": { "compartment": "compartment_7660", "id": "reaction_10474610", "reactome": "R-DME-5652151", "name": "REV1 recruits POLZ to (AP:Cyt)-DNA Template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433993", "species_10433978" ], "products": [ "species_10433995" ], "modifiers": [], "additional_components": [ "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891" ] }, "reaction_10434002": { "compartment": "compartment_7660", "id": "reaction_10434002", "reactome": "R-DME-110311", "name": "POLZ extends translesion synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10433995" ], "products": [ "species_10433993", "species_113541", "species_10433999" ], "modifiers": [ [ "species_10433995", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891" ] }, "reaction_10475337": { "compartment": "compartment_7660", "id": "reaction_10475337", "reactome": "R-DME-5656158", "name": "POLZ elongates POLI-incorporated dNMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10475325" ], "products": [ "species_10433955", "species_10475334", "species_10433993", "species_113541" ], "modifiers": [ [ "species_10475325", "catalyst" ] ], "additional_components": [ "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "FBgn0035150", "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150" ] }, "reaction_10475319": { "compartment": "compartment_7660", "id": "reaction_10475319", "reactome": "R-DME-5656105", "name": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475315", "species_10433955", "species_10433993", "species_10475311" ], "products": [ "species_10475317" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9VHV1", "FBgn0037554", "species_29926", "Q9VHV1", "FBgn0037554", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10475328": { "compartment": "compartment_7660", "id": "reaction_10475328", "reactome": "R-DME-5656148", "name": "POLI incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10475317" ], "products": [ "species_113541", "species_10475325" ], "modifiers": [ [ "species_10475317", "catalyst" ] ], "additional_components": [ "Q9VHV1", "FBgn0037554", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "Q9VHV1", "FBgn0037554", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10474686": { "compartment": "compartment_7660", "id": "reaction_10474686", "reactome": "R-DME-5653838", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434065", "species_10474682" ], "products": [ "species_10474684" ], "modifiers": [], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10474680": { "compartment": "compartment_7660", "id": "reaction_10474680", "reactome": "R-DME-5653780", "name": "USP43 binds ISG:K164,ISG:K168-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474672", "species_10474676" ], "products": [ "species_10474678" ], "modifiers": [], "additional_components": [ "FBgn0050421", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q9W117", "FBgn0050421" ] }, "reaction_10434030": { "compartment": "compartment_7660", "id": "reaction_10434030", "reactome": "R-DME-110317", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29604", "species_10434013" ], "products": [ "species_113541", "species_10434027" ], "modifiers": [ [ "species_10434013", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141" ] }, "reaction_10475228": { "compartment": "compartment_7660", "id": "reaction_10475228", "reactome": "R-DME-5654989", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10475219" ], "products": [ "species_113582", "species_10434007", "species_10475225" ], "modifiers": [ [ "species_10475219", "catalyst" ] ], "additional_components": [ "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784", "FBgn0037141", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784" ] }, "reaction_10475243": { "compartment": "compartment_7660", "id": "reaction_10475243", "reactome": "R-DME-5655170", "name": "RCHY1 monoubiquitinates POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10475230" ], "products": [ "species_10434018", "species_10475240" ], "modifiers": [ [ "species_10475230", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VNX1", "FBgn0037141", "Q9VMD4", "FBgn0031816", "FBgn0031816", "Q9VNX1", "FBgn0037141", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VNX1", "FBgn0037141", "Q9VMD4", "FBgn0031816" ] }, "reaction_10475223": { "compartment": "compartment_7660", "id": "reaction_10475223", "reactome": "R-DME-5654986", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434034", "species_10475199" ], "products": [ "species_10475201" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "FBgn0267977", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141" ] }, "reaction_10434037": { "compartment": "compartment_7660", "id": "reaction_10434037", "reactome": "R-DME-110319", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10434027" ], "products": [ "species_10434034", "species_113541" ], "modifiers": [ [ "species_10434027", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141" ] }, "reaction_10475221": { "compartment": "compartment_7660", "id": "reaction_10475221", "reactome": "R-DME-5654985", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475217", "species_10475201" ], "products": [ "species_10475219" ], "modifiers": [], "additional_components": [ "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784" ] }, "reaction_10434020": { "compartment": "compartment_7660", "id": "reaction_10434020", "reactome": "R-DME-110316", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434007", "species_10434011" ], "products": [ "species_10434013" ], "modifiers": [ [ "species_10434018", "inhibitor" ] ], "additional_components": [ "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "FBgn0031816" ] }, "reaction_10475232": { "compartment": "compartment_7660", "id": "reaction_10475232", "reactome": "R-DME-5655142", "name": "RCHY1 binds POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434018", "species_10434007" ], "products": [ "species_10475230" ], "modifiers": [], "additional_components": [ "FBgn0031816", "FBgn0037141", "Q9VNX1", "FBgn0037141", "Q9VMD4", "FBgn0031816" ] }, "reaction_10479709": { "compartment": "compartment_7660", "id": "reaction_10479709", "reactome": "R-DME-6785594", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479700", "species_10479705" ], "products": [ "species_10479707" ], "modifiers": [], "additional_components": [ "FBgn0038827", "FBgn0033354", "A1Z7L1", "FBgn0033354", "Q8MYL1", "FBgn0038827" ] }, "reaction_10449934": { "compartment": "compartment_876", "id": "reaction_10449934", "reactome": "R-DME-444008", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_114523", "species_74113" ], "products": [ "species_209914", "species_83910", "species_352022" ], "modifiers": [ [ "species_10449931", "catalyst" ] ], "additional_components": [ "FBgn0010414" ] }, "reaction_10445846": { "compartment": "compartment_5460", "id": "reaction_10445846", "reactome": "R-DME-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10429091", "catalyst" ] ], "additional_components": [ "Q9VLC5", "FBgn0012036" ] }, "reaction_10444860": { "compartment": "compartment_984", "id": "reaction_10444860", "reactome": "R-DME-374919", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10497879": { "compartment": "compartment_876", "id": "reaction_10497879", "reactome": "R-DME-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444352", "species_9634838" ], "products": [ "species_10444355" ], "modifiers": [], "additional_components": [ "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943", "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943" ] }, "reaction_10444357": { "compartment": "compartment_984", "id": "reaction_10444357", "reactome": "R-DME-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10444352", "catalyst" ], [ "species_10444355", "inhibitor" ] ], "additional_components": [ "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943", "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943" ] }, "reaction_10486033": { "compartment": "compartment_7660", "id": "reaction_10486033", "reactome": "R-DME-6804468", "name": "PIAS1 SUMOylates SP3 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467290", "species_10467901" ], "products": [ "species_10486031", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q9VPQ5", "FBgn0043364", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "M9PJG1", "FBgn0020378", "Q24266", "FBgn0000233", "Q2MGN0", "FBgn0034946", "Q9VPQ5", "FBgn0043364", "FBgn0010602", "FBgn0003612" ] }, "reaction_10470035": { "compartment": "compartment_7660", "id": "reaction_10470035", "reactome": "R-DME-4641350", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470028" ], "products": [ "species_10470033", "species_10467222" ], "modifiers": [ [ "species_10469560", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0284220", "FBgn0284220", "FBgn0010602", "FBgn0003612" ] }, "reaction_10470128": { "compartment": "compartment_70101", "id": "reaction_10470128", "reactome": "R-DME-4655355", "name": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470071" ], "products": [ "species_10470093", "species_10470095" ], "modifiers": [ [ "species_10469818", "catalyst" ], [ "species_10470125", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q7JRJ9", "FBgn0260991", "Q9VLD6", "FBgn0032105", "Q9VLD7", "FBgn0032104", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VLD7", "FBgn0032104", "Q9VLD6", "FBgn0032105", "Q7JRJ9", "FBgn0260991", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "FBgn0010602", "FBgn0003612", "A1YK02", "FBgn0034310", "A1Z8P9", "FBgn0013756", "Q9VE85", "FBgn0038609", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VCH5", "FBgn0039120", "Q9VBU8", "FBgn0039301", "Q9V466", "FBgn0027868", "Q9VCW3", "FBgn0039004", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "A1Z6H7", "FBgn0266580", "Q8IQV9", "FBgn0031078", "Q7K0D8", "FBgn0033264", "Q7KNM2", "FBgn0010602", "Q9VIW3", "FBgn0003346", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9VWS2", "FBgn0030943", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VFE7", "FBgn0038274", "Q7K2X8", "FBgn0033247", "Q9VXE6", "FBgn0061200", "Q9V463", "FBgn0021761" ] }, "reaction_10470191": { "compartment": "compartment_7660", "id": "reaction_10470191", "reactome": "R-DME-4755524", "name": "SUMOylation of NR1I2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10470184" ], "products": [ "species_10467222", "species_10470189" ], "modifiers": [], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "Q24143", "FBgn0015240", "CHEBI:28077", "FBgn0010602", "Q24143", "FBgn0015240", "CHEBI:28077" ] }, "reaction_10470143": { "compartment": "compartment_7660", "id": "reaction_10470143", "reactome": "R-DME-4719413", "name": "PIAS2,3,4 SUMOylate RORA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445281", "species_10467290" ], "products": [ "species_10467222", "species_10470138" ], "modifiers": [ [ "species_10470140", "catalyst" ] ], "additional_components": [ "P45447", "FBgn0004865", "P31396", "FBgn0000448", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "P45447", "FBgn0004865", "P31396", "FBgn0000448", "FBgn0003612" ] }, "reaction_10469820": { "compartment": "compartment_7660", "id": "reaction_10469820", "reactome": "R-DME-4546385", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445316", "species_10467290" ], "products": [ "species_10467222", "species_10469816" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0001078", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "FBgn0001078", "FBgn0003612" ] }, "reaction_10470156": { "compartment": "compartment_7660", "id": "reaction_10470156", "reactome": "R-DME-4719448", "name": "PIAS1 SUMOylates THRB with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10445311" ], "products": [ "species_10467222", "species_10470154" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "FBgn0000568", "FBgn0010602", "FBgn0000568", "FBgn0003612" ] }, "reaction_10470167": { "compartment": "compartment_7660", "id": "reaction_10470167", "reactome": "R-DME-4720432", "name": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470158" ], "products": [ "species_10470164", "species_10467222" ], "modifiers": [ [ "species_10469978", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:1301", "CHEBI:34310", "CHEBI:1301", "P34021", "FBgn0000546", "FBgn0010602", "FBgn0041210" ] }, "reaction_10469718": { "compartment": "compartment_7660", "id": "reaction_10469718", "reactome": "R-DME-4341072", "name": "SUMOylation of RARA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445299", "species_10467290" ], "products": [ "species_10469715", "species_10467222" ], "modifiers": [ [ "species_10467290", "catalyst" ] ], "additional_components": [ "FBgn0000568", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0000568", "FBgn0010602", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10470149": { "compartment": "compartment_7660", "id": "reaction_10470149", "reactome": "R-DME-4719423", "name": "PIAS2-2 SUMOylates THRA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10445309" ], "products": [ "species_10470147", "species_10467222" ], "modifiers": [ [ "species_10470140", "catalyst" ] ], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "FBgn0000568", "FBgn0000568", "FBgn0010602", "FBgn0003612" ] }, "reaction_10469826": { "compartment": "compartment_7660", "id": "reaction_10469826", "reactome": "R-DME-4546387", "name": "PIAS4 SUMOylates VDR with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445234", "species_10467290" ], "products": [ "species_10467222", "species_10469823" ], "modifiers": [ [ "species_10469560", "catalyst" ] ], "additional_components": [ "FBgn0015240", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "FBgn0015240", "FBgn0003612" ] }, "reaction_10470176": { "compartment": "compartment_7660", "id": "reaction_10470176", "reactome": "R-DME-4720446", "name": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470169" ], "products": [ "species_10467222", "species_10470174" ], "modifiers": [ [ "species_10469978", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:1301", "FBgn0010602", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:1301", "FBgn0041210" ] }, "reaction_10470211": { "compartment": "compartment_7660", "id": "reaction_10470211", "reactome": "R-DME-4755536", "name": "PIAS3 SUMOylates RELA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470193", "species_10467298" ], "products": [ "species_10470209", "species_10467222" ], "modifiers": [ [ "species_10469818", "catalyst" ] ], "additional_components": [ "P98149", "Dif", "P15330", "dl", "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "P98149", "Dif", "P15330", "dl", "FBgn0010602", "FBgn0003612" ] }, "reaction_10469909": { "compartment": "compartment_7660", "id": "reaction_10469909", "reactome": "R-DME-4570499", "name": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429333", "species_10467290" ], "products": [ "species_10469907", "species_10467222" ], "modifiers": [ [ "species_10467488", "catalyst" ] ], "additional_components": [ "FBgn0267791", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0267791", "FBgn0010602", "P26017", "FBgn0003042", "Q9VB08", "FBgn0003330", "Q9VHA0", "FBgn0003334", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "P39769", "FBgn0004861", "Q9VKL0", "FBgn0032330", "Q9W523", "FBgn0004860" ] }, "reaction_10469904": { "compartment": "compartment_7660", "id": "reaction_10469904", "reactome": "R-DME-4570489", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467290", "species_10469898" ], "products": [ "species_10467222", "species_10469902" ], "modifiers": [ [ "species_10467290", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0026196", "FBgn0010602", "FBgn0026196", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469992": { "compartment": "compartment_7660", "id": "reaction_10469992", "reactome": "R-DME-4615987", "name": "RANBP2 SUMOylates HDAC4 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469978" ], "products": [ "species_10469989", "species_10467222" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0041210", "FBgn0041210", "FBgn0010602", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10469973": { "compartment": "compartment_7660", "id": "reaction_10469973", "reactome": "R-DME-4615839", "name": "PIAS1 SUMOylates SATB1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10444232" ], "products": [ "species_10469971", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0020307", "FBgn0020307", "FBgn0010602", "FBgn0003612" ] }, "reaction_10486044": { "compartment": "compartment_7660", "id": "reaction_10486044", "reactome": "R-DME-6804485", "name": "PIAS1 SUMOylates L3MBTL2 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486038", "species_10467290" ], "products": [ "species_10486042", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0032475", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0032475", "FBgn0010602", "FBgn0003612" ] }, "reaction_10469986": { "compartment": "compartment_7660", "id": "reaction_10469986", "reactome": "R-DME-4615900", "name": "PIAS1 SUMOylates SATB2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10469980" ], "products": [ "species_10469984", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "FBgn0020307", "FBgn0020307", "FBgn0010602", "FBgn0003612" ] }, "reaction_10467179": { "compartment": "compartment_7660", "id": "reaction_10467179", "reactome": "R-DME-2990842", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467152" ], "products": [ "species_10467154" ], "modifiers": [ [ "species_10467176", "catalyst" ] ], "additional_components": [ "FBgn0264922", "FBgn0264922", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110" ] }, "reaction_10467217": { "compartment": "compartment_7660", "id": "reaction_10467217", "reactome": "R-DME-2993763", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467213" ], "products": [ "species_10467215" ], "modifiers": [ [ "species_10467176", "catalyst" ] ], "additional_components": [ "FBgn0264922", "FBgn0264922", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110" ] }, "reaction_10493344": { "compartment": "compartment_7660", "id": "reaction_10493344", "reactome": "R-DME-8943817", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493338", "species_10493336" ], "products": [ "species_10493342" ], "modifiers": [], "additional_components": [ "Q8I7Z8", "FBgn0045852", "Q8I7Z8", "FBgn0045852" ] }, "reaction_10493329": { "compartment": "compartment_7660", "id": "reaction_10493329", "reactome": "R-DME-8943780", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493323", "species_10493319" ], "products": [ "species_10493327" ], "modifiers": [], "additional_components": [ "Q94517", "HDAC1", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q24572", "FBgn0263979", "Q9VKH3", "FBgn0000287", "P39770", "FBgn0261648", "Q9VKH3", "FBgn0000287", "P39770", "FBgn0261648", "Q94517", "HDAC1", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q24572", "FBgn0263979" ] }, "reaction_10493377": { "compartment": "compartment_13231", "id": "reaction_10493377", "reactome": "R-DME-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493368" ], "products": [ "species_10493366" ], "modifiers": [ [ "species_10437040", "inhibitor" ] ], "additional_components": [ "FBgn0267861", "FBgn0267861", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10493375": { "compartment": "compartment_70101", "id": "reaction_10493375", "reactome": "R-DME-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10493368" ], "products": [ "species_10493373", "species_29370" ], "modifiers": [ [ "species_10437040", "catalyst" ] ], "additional_components": [ "FBgn0267861", "FBgn0267861", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10467806": { "compartment": "compartment_70101", "id": "reaction_10467806", "reactome": "R-DME-3228469", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10450922" ], "products": [ "species_10450883", "species_29370" ], "modifiers": [ [ "species_10467790", "catalyst" ] ], "additional_components": [ "FBgn0261524", "FBgn0261524", "FBgn0014006" ] }, "reaction_10467802": { "compartment": "compartment_70101", "id": "reaction_10467802", "reactome": "R-DME-3225851", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467792", "species_1250243" ], "products": [ "species_10430994", "species_10467790" ], "modifiers": [ [ "species_10467796", "catalyst" ] ], "additional_components": [ "Q9VDS9", "FBgn0014006", "Q9V429", "FBgn0040070", "FBgn0040070", "FBgn0014006" ] }, "reaction_10495401": { "compartment": "compartment_7660", "id": "reaction_10495401", "reactome": "R-DME-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495397", "species_111793" ], "products": [ "species_10495399" ], "modifiers": [], "additional_components": [ "FBgn0260749", "species_111793", "Q9VL07", "FBgn0260749" ] }, "reaction_10467889": { "compartment": "compartment_7660", "id": "reaction_10467889", "reactome": "R-DME-3240957", "name": "Formation of PRC2-EZH2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458993", "species_10467875", "species_10467880", "species_10467885" ], "products": [ "species_10467887" ], "modifiers": [], "additional_components": [ "FBgn0263979", "FBgn0032391", "FBgn0000629", "FBgn0020887", "Q9NJG9", "FBgn0020887", "P42124", "FBgn0000629", "Q9VKD5", "FBgn0032391", "Q24572", "FBgn0263979" ] }, "reaction_10473727": { "compartment": "compartment_13949", "id": "reaction_10473727", "reactome": "R-DME-5623524", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473705", "species_10473723" ], "products": [ "species_10473725" ], "modifiers": [], "additional_components": [ "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "species_29438", "O18335", "FBgn0015790", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9V8K2", "FBgn0266671", "Q9VQQ9", "FBgn0266670", "Q9VVG4", "FBgn0266669", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VDE6", "FBgn0266674", "Q9XTM1", "FBgn0266673", "Q9VNH6", "FBgn0266672", "Q9V8K2", "FBgn0266671", "Q9VQQ9", "FBgn0266670", "Q9VVG4", "FBgn0266669", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VDE6", "FBgn0266674", "Q9XTM1", "FBgn0266673", "Q9VNH6", "FBgn0266672", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "species_29438", "O18335", "FBgn0015790", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145" ] }, "reaction_10473635": { "compartment": "compartment_70101", "id": "reaction_10473635", "reactome": "R-DME-5623508", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10473633" ], "products": [ "species_29420", "species_10473517" ], "modifiers": [ [ "species_10444051", "catalyst" ] ], "additional_components": [ "P40945", "FBgn0013749", "species_29420", "P40945", "FBgn0013749", "species_29438", "FBgn0264560" ] }, "reaction_10473683": { "compartment": "compartment_20699", "id": "reaction_10473683", "reactome": "R-DME-5623513", "name": "ASAP1 stimulates GTPase activity of ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10473678" ], "products": [ "species_10473680", "species_10473633", "species_29372" ], "modifiers": [ [ "species_10473678", "catalyst" ] ], "additional_components": [ "O18335", "FBgn0015790", "species_29438", "M9ND89", "FBgn0013718", "P40945", "FBgn0013749", "A1Z7A6", "FBgn0050372", "O18335", "FBgn0015790", "species_29438", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "P40945", "FBgn0013749", "species_29420", "O18335", "FBgn0015790", "species_29438", "M9ND89", "FBgn0013718", "P40945", "FBgn0013749", "A1Z7A6", "FBgn0050372" ] }, "reaction_10473745": { "compartment": "compartment_261122", "id": "reaction_10473745", "reactome": "R-DME-5623527", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473725" ], "products": [ "species_10473743" ], "modifiers": [], "additional_components": [ "Q9V8K2", "FBgn0266671", "Q9VQQ9", "FBgn0266670", "Q9VVG4", "FBgn0266669", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VDE6", "FBgn0266674", "Q9XTM1", "FBgn0266673", "Q9VNH6", "FBgn0266672", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "species_29438", "O18335", "FBgn0015790", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145" ] }, "reaction_10433822": { "compartment": "compartment_70101", "id": "reaction_10433822", "reactome": "R-DME-110133", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500077" ], "products": [ "species_113592", "species_500071" ], "modifiers": [ [ "species_10431187", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:28862", "species_5696194", "CHEBI:16192", "FBgn0036099" ] }, "reaction_10452894": { "compartment": "compartment_70101", "id": "reaction_10452894", "reactome": "R-DME-482621", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_482625" ], "products": [ "species_113592", "species_482627" ], "modifiers": [ [ "species_10452889", "catalyst" ] ], "additional_components": [ "species_29892", "species_29604", "species_30185", "species_29494", "species_30187", "species_110577", "species_500739", "species_29438", "species_205687", "CHEBI:28846", "CHEBI:16174", "species_29420", "CHEBI:28850", "CHEBI:28862", "CHEBI:18075", "species_110094", "P08879", "FBgn0000150" ] }, "reaction_10480029": { "compartment": "compartment_7660", "id": "reaction_10480029", "reactome": "R-DME-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6788813" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10480026", "catalyst" ] ], "additional_components": [ "CHEBI:15918", "species_1524067", "species_76577", "species_109386", "species_110094", "CHEBI:16174", "CHEBI:28846", "species_29370", "FBgn0033754" ] }, "reaction_10432346": { "compartment": "compartment_70101", "id": "reaction_10432346", "reactome": "R-DME-75126", "name": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_499999" ], "products": [ "species_499997", "species_113592" ], "modifiers": [ [ "species_10430985", "catalyst" ] ], "additional_components": [ "CHEBI:28850", "CHEBI:18075", "species_109382", "species_109366", "A1ZB29", "FBgn0034299" ] }, "reaction_10432344": { "compartment": "compartment_70101", "id": "reaction_10432344", "reactome": "R-DME-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500006" ], "products": [ "species_500009", "species_113592" ], "modifiers": [ [ "species_10430860", "catalyst" ] ], "additional_components": [ "species_205687", "CHEBI:28846", "species_110094", "species_1524067", "CHEBI:15918", "species_418075", "Q9VBI2", "FBgn0028833" ] }, "reaction_10480021": { "compartment": "compartment_5460", "id": "reaction_10480021", "reactome": "R-DME-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6788802" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10480018", "catalyst" ] ], "additional_components": [ "species_1524067", "species_109386", "species_76577", "CHEBI:15918", "species_29370", "CHEBI:16174", "CHEBI:28846", "species_110094", "FBgn0042094" ] }, "reaction_10486254": { "compartment": "compartment_70101", "id": "reaction_10486254", "reactome": "R-DME-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6806885" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10486251", "catalyst" ] ], "additional_components": [ "P08879", "FBgn0000150" ] }, "reaction_10431502": { "compartment": "compartment_70101", "id": "reaction_10431502", "reactome": "R-DME-74220", "name": "(d)AMP + ATP <=> (d)ADP + ADP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500088", "species_113592" ], "products": [ "species_29370", "species_500087" ], "modifiers": [ [ "species_10431499", "catalyst" ] ], "additional_components": [ "species_76577", "species_109386", "species_29370", "CHEBI:16174", "Q8IQG9", "FBgn0022709" ] }, "reaction_10453058": { "compartment": "compartment_70101", "id": "reaction_10453058", "reactome": "R-DME-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10453055", "catalyst" ] ], "additional_components": [ "Q9VUL1", "FBgn0266452" ] }, "reaction_10433850": { "compartment": "compartment_70101", "id": "reaction_10433850", "reactome": "R-DME-110145", "name": "AMP + ATP <=> ADP + ADP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76577" ], "products": [ "species_29370" ], "modifiers": [ [ "species_10433845", "catalyst" ] ], "additional_components": [ "FBgn0283494" ] }, "reaction_10434170": { "compartment": "compartment_70101", "id": "reaction_10434170", "reactome": "R-DME-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_8866401" ], "products": [ "species_10430994", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10434167", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "species_1222611", "P48592", "FBgn0011704", "P48591", "FBgn0011703" ] }, "reaction_10431033": { "compartment": "compartment_7660", "id": "reaction_10431033", "reactome": "R-DME-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10431030", "catalyst" ] ], "additional_components": [ "Q9V3I1", "FBgn0250837" ] }, "reaction_10430962": { "compartment": "compartment_70101", "id": "reaction_10430962", "reactome": "R-DME-73605", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355", "species_109382" ], "products": [ "species_109366", "species_73604" ], "modifiers": [ [ "species_10430959", "catalyst" ] ], "additional_components": [ "O76511", "FBgn0024920", "species_29926" ] }, "reaction_10434161": { "compartment": "compartment_70101", "id": "reaction_10434161", "reactome": "R-DME-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_8866401" ], "products": [ "species_10430994", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10434158", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "P48592", "FBgn0011704", "species_1222611", "P48591", "FBgn0011703" ] }, "reaction_10431023": { "compartment": "compartment_70101", "id": "reaction_10431023", "reactome": "R-DME-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10431020", "catalyst" ] ], "additional_components": [ "Q9VUL1", "FBgn0266452" ] }, "reaction_10433838": { "compartment": "compartment_70101", "id": "reaction_10433838", "reactome": "R-DME-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10433833", "catalyst" ] ], "additional_components": [ "species_76577", "species_1524067", "CHEBI:15918", "species_109386", "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "Q8IQG9", "FBgn0022709", "M9PCF9", "FBgn0032083" ] }, "reaction_10433836": { "compartment": "compartment_70101", "id": "reaction_10433836", "reactome": "R-DME-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10433833", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "species_76577", "species_1524067", "CHEBI:15918", "species_109386", "Q8IQG9", "FBgn0022709", "M9PCF9", "FBgn0032083" ] }, "reaction_10453032": { "compartment": "compartment_5460", "id": "reaction_10453032", "reactome": "R-DME-482812", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113581", "species_482807" ], "products": [ "species_113593", "species_482803" ], "modifiers": [ [ "species_10453027", "catalyst" ] ], "additional_components": [ "species_110577", "species_29438", "species_500739", "species_29892", "species_29494", "species_29604", "species_30185", "species_30187", "CHEBI:18075", "species_29420", "CHEBI:28850", "CHEBI:28862", "species_205687", "CHEBI:16174", "CHEBI:28846", "species_110094", "P08879", "FBgn0000150" ] }, "reaction_10480797": { "compartment": "compartment_7660", "id": "reaction_10480797", "reactome": "R-DME-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480711" ], "products": [ "species_10480770" ], "modifiers": [ [ "species_10480794", "catalyst" ], [ "species_10480430", "catalyst" ], [ "species_10480782", "catalyst" ], [ "species_10480418", "catalyst" ] ], "additional_components": [ "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VGZ2", "FBgn0037815", "Q9VK19", "FBgn0032487", "Q8IPX7", "FBgn0260648", "Q9W1M9", "FBgn0034879", "Q9VKJ4", "FBgn0032346", "Q8T4A9", "FBgn0030789", "Q29QQ9", "FBgn0034065", "Q9VW53", "FBgn0036916", "Q9VFF3", "FBgn0038269", "Q9VXL4", "FBgn0030711", "Q95PE4", "FBgn0032921", "Q9Y134", "FBgn0001986", "FBgn0038269", "FBgn0037815", "FBgn0001986" ] }, "reaction_10480745": { "compartment": "compartment_7660", "id": "reaction_10480745", "reactome": "R-DME-6791221", "name": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480707" ], "products": [ "species_10480711" ], "modifiers": [ [ "species_10480713", "catalyst" ], [ "species_10430268", "catalyst" ], [ "species_10480715", "catalyst" ], [ "species_10480694", "catalyst" ], [ "species_10480689", "catalyst" ], [ "species_10480683", "catalyst" ], [ "species_10480681", "catalyst" ], [ "species_10480546", "catalyst" ], [ "species_10480630", "catalyst" ], [ "species_10480717", "catalyst" ], [ "species_10480719", "catalyst" ], [ "species_10480721", "catalyst" ], [ "species_10480723", "catalyst" ], [ "species_10480725", "catalyst" ], [ "species_10480727", "catalyst" ], [ "species_10480729", "catalyst" ], [ "species_10480731", "catalyst" ], [ "species_10480733", "catalyst" ], [ "species_10480738", "catalyst" ], [ "species_10480679", "catalyst" ], [ "species_10480743", "catalyst" ] ], "additional_components": [ "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "FBgn0039300", "FBgn0004867", "FBgn0261596", "FBgn0036886", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "FBgn0010408", "FBgn0039757", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "FBgn0010520", "FBgn0034743", "FBgn0033912", "FBgn0010265", "FBgn0017545", "FBgn0002590", "FBgn0030136", "FBgn0010198", "FBgn0039713", "FBgn0033699", "FBgn0030720", "FBgn0261592", "FBgn0039233" ] }, "reaction_10480933": { "compartment": "compartment_7660", "id": "reaction_10480933", "reactome": "R-DME-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480919" ], "products": [ "species_10480923" ], "modifiers": [ [ "species_10480928", "catalyst" ], [ "species_10480546", "catalyst" ], [ "species_10480595", "catalyst" ], [ "species_10480931", "catalyst" ], [ "species_10480571", "catalyst" ], [ "species_10480694", "catalyst" ], [ "species_10480418", "catalyst" ] ], "additional_components": [ "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "FBgn0031868", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "FBgn0003742", "FBgn0262560", "FBgn0036886", "FBgn0001986" ] }, "reaction_10480467": { "compartment": "compartment_7660", "id": "reaction_10480467", "reactome": "R-DME-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480451" ], "products": [ "species_10480408" ], "modifiers": [ [ "species_10480465", "catalyst" ], [ "species_10480449", "catalyst" ], [ "species_10480395", "catalyst" ], [ "species_10480400", "catalyst" ] ], "additional_components": [ "Q8SZY9", "FBgn0052075", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110", "Q9W3K4", "FBgn0029999", "Q8MS38", "FBgn0053217", "Q9W550", "FBgn0023514", "Q9VKQ3", "FBgn0032298", "Q9VL96", "FBgn0032138", "Q7K0Y1", "FBgn0028744", "A1ZA92", "FBgn0034073", "Q8SZY9", "FBgn0052075", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110", "Q9W3K4", "FBgn0029999", "Q8MS38", "FBgn0053217", "Q9W550", "FBgn0023514", "A1ZA92", "FBgn0034073", "Q8MT06", "FBgn0038473", "Q9V9Z9", "FBgn0039828", "Q9VL96", "FBgn0032138", "Q9VKQ3", "FBgn0032298", "Q9VL96", "FBgn0032138", "Q7K0Y1", "FBgn0028744", "FBgn0052075", "FBgn0034073" ] }, "reaction_10468641": { "compartment": "compartment_7660", "id": "reaction_10468641", "reactome": "R-DME-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468620", "species_10468637" ], "products": [ "species_10468639" ], "modifiers": [], "additional_components": [ "P22813", "FBgn0001222", "Q9VK90", "FBgn0032429", "Q9VK90", "FBgn0032429", "P22813", "FBgn0001222" ] }, "reaction_10493657": { "compartment": "compartment_70101", "id": "reaction_10493657", "reactome": "R-DME-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493653" ], "products": [ "species_10493655" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493663": { "compartment": "compartment_70101", "id": "reaction_10493663", "reactome": "R-DME-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718", "species_10493632" ], "products": [ "species_10493653" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_350388": { "compartment": "compartment_70101", "id": "reaction_350388", "reactome": "R-DME-350388", "name": "ROK binds to activated RHO1:GTP", "reversible": "false", "notes": "Rho-kinase (ROK) aka Drok binds to activated Rho GTPase (RHO1:GTP) and is itself activated. The conserved Rho-binding site in ROK is the area of interaction.", "reactants": [ "species_450801", "species_350932" ], "products": [ "species_450785" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641", "Q9U779", "ROK", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_350391": { "compartment": "compartment_876", "id": "reaction_350391", "reactome": "R-DME-350391", "name": "RHO1:GTP binds to activated DAAM", "reversible": "false", "notes": "Activated Rho GTPase (RHO1:GTP) binds to activated Dishevelled Associated Activator of Morphogenesis (DAAM) complexed to Dishevelled (DSH). DAAM is a bridging factor between DSH and RHO1.", "reactants": [ "species_450703", "species_350950" ], "products": [ "species_450801" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641", "species_29438", "P48148", "Rho1", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_350396": { "compartment": "compartment_70101", "id": "reaction_350396", "reactome": "R-DME-350396", "name": "DSH binds to DAAM", "reversible": "false", "notes": "Dishevelled Associated Activator of Morphogenesis (DAAM) is autoinhibited by intramolecular interactions between its GBD and DAD domains. Dishevelled (DSH) binds to the DAD domain of DAAM and disrupts the autoinhibitory interaction, thus activating DAAM.", "reactants": [ "species_351034", "species_450734" ], "products": [ "species_450703" ], "modifiers": [], "additional_components": [ "FBgn0025641", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_10470444": { "compartment": "compartment_7660", "id": "reaction_10470444", "reactome": "R-DME-5159250", "name": "ATF7IP binds SETDB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470435", "species_10470440" ], "products": [ "species_10470442" ], "modifiers": [], "additional_components": [ "FBgn0027499", "FBgn0086908", "Q32KD2", "FBgn0086908", "Q7KMH9", "FBgn0027499" ] }, "reaction_10495537": { "compartment": "compartment_876", "id": "reaction_10495537", "reactome": "R-DME-8981353", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495534" ], "products": [ "species_10438980", "species_10439352" ], "modifiers": [ [ "species_10495534", "catalyst" ], [ "species_10488125", "inhibitor" ] ], "additional_components": [ "Q8IR23", "FBgn0003969", "species_29438", "P08646", "RAS85D", "P08646", "RAS85D", "species_29420", "FBgn0003969", "Q8IR23", "FBgn0003969", "species_29438", "P08646", "RAS85D", "Q9VX32", "RhoGAPp190", "Q8IR23", "FBgn0003969" ] }, "reaction_10495540": { "compartment": "compartment_876", "id": "reaction_10495540", "reactome": "R-DME-8981355", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10439352" ], "products": [ "species_10495534" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "FBgn0003969", "Q8IR23", "FBgn0003969", "species_29438", "P08646", "RAS85D" ] }, "reaction_10487958": { "compartment": "compartment_876", "id": "reaction_10487958", "reactome": "R-DME-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464321", "species_29438" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10487955", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "Q9XYM0", "FBgn0024811", "Q9VKB2", "FBgn0032409", "Q2PDT4", "FBgn0041789" ] }, "reaction_10488121": { "compartment": "compartment_70101", "id": "reaction_10488121", "reactome": "R-DME-8849082", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488118" ], "products": [ "species_29372", "species_10434904", "species_10488116" ], "modifiers": [ [ "species_10488118", "catalyst" ] ], "additional_components": [ "Q9VX32", "RhoGAPp190", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420", "Q9VX32", "RhoGAPp190", "P48148", "Rho1", "species_29438" ] }, "reaction_10488123": { "compartment": "compartment_70101", "id": "reaction_10488123", "reactome": "R-DME-8849085", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434906", "species_10488116" ], "products": [ "species_10488118" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "Q9VX32", "RhoGAPp190", "P48148", "Rho1", "species_29438" ] }, "reaction_10488127": { "compartment": "compartment_70101", "id": "reaction_10488127", "reactome": "R-DME-8849094", "name": "ARHGAP35 binds RASA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439352", "species_10488116" ], "products": [ "species_10488125" ], "modifiers": [], "additional_components": [ "FBgn0003969", "Q9VX32", "RhoGAPp190", "Q8IR23", "FBgn0003969" ] }, "reaction_10487964": { "compartment": "compartment_70101", "id": "reaction_10487964", "reactome": "R-DME-8848829", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454432", "species_10426987" ], "products": [ "species_10487961" ], "modifiers": [ [ "species_10454432", "catalyst" ] ], "additional_components": [ "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0020224", "FBgn0020224" ] }, "reaction_10488040": { "compartment": "compartment_7660", "id": "reaction_10488040", "reactome": "R-DME-8848993", "name": "Phosphorylated KHDRBS1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488022" ], "products": [ "species_10488038" ], "modifiers": [], "additional_components": [ "O44434", "FBgn0022984", "Q9W240", "FBgn0034739", "Q9W254", "FBgn0022985", "Q9W2D0", "FBgn0034659", "Q9W224", "FBgn0034740", "Q9W249", "FBgn0034731", "Q9W255", "FBgn0022986", "Q9W254", "FBgn0022985", "Q9W255", "FBgn0022986", "Q9W2D0", "FBgn0034659", "O44434", "FBgn0022984", "Q9W224", "FBgn0034740", "Q9W240", "FBgn0034739", "Q9W249", "FBgn0034731" ] }, "reaction_10469023": { "compartment": "compartment_876", "id": "reaction_10469023", "reactome": "R-DME-3791155", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443411" ], "products": [ "species_10469021" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "P11046", "FBgn0261800", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "FBgn0035049" ] }, "reaction_10479128": { "compartment": "compartment_5460", "id": "reaction_10479128", "reactome": "R-DME-5696408", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696409", "species_113521" ], "products": [ "species_113548", "species_5693978", "species_113556" ], "modifiers": [ [ "species_10479125", "catalyst" ] ], "additional_components": [ "Q9VU95", "FBgn0036381" ] }, "reaction_10466188": { "compartment": "compartment_984", "id": "reaction_10466188", "reactome": "R-DME-2534248", "name": "DCN (decorin) degradation by MMP2, MMP3, MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465552" ], "products": [ "species_10466183", "species_10466185" ], "modifiers": [ [ "species_10459266", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "FBgn0028872", "FBgn0035049" ] }, "reaction_10459276": { "compartment": "compartment_984", "id": "reaction_10459276", "reactome": "R-DME-1454781", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459252", "species_10459247" ], "products": [ "species_10459274" ], "modifiers": [], "additional_components": [ "FBgn0035049", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9W122", "FBgn0035049" ] }, "reaction_10469689": { "compartment": "compartment_876", "id": "reaction_10469689", "reactome": "R-DME-4224014", "name": "E-cadherin degradation by ADAM10, ADAM15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469032" ], "products": [ "species_10469040", "species_10469036" ], "modifiers": [ [ "species_10469686", "catalyst" ] ], "additional_components": [ "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "Q6QU65", "FBgn0265140", "Q9VJW9", "FBgn0259984" ] }, "reaction_10460413": { "compartment": "compartment_984", "id": "reaction_10460413", "reactome": "R-DME-1604690", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460226" ], "products": [ "species_10459272", "species_10460411" ], "modifiers": [ [ "species_10459252", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460058": { "compartment": "compartment_984", "id": "reaction_10460058", "reactome": "R-DME-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460055" ], "products": [ "species_10459252" ], "modifiers": [ [ "species_10459266", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460378": { "compartment": "compartment_17963", "id": "reaction_10460378", "reactome": "R-DME-1602484", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460376" ], "products": [ "species_10459260" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0004509" ] }, "reaction_10460185": { "compartment": "compartment_984", "id": "reaction_10460185", "reactome": "R-DME-1592316", "name": "Initial activation of proMMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460060" ], "products": [ "species_10460064", "species_10460062" ], "modifiers": [ [ "species_10460182", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "Q9VUG2", "FBgn0036436", "P13582", "ProEA", "Q9I7V4", "FBgn0042098", "M9NDV6", "FBgn0036817", "Q9VUF0", "FBgn0036427", "Q8MLV8", "FBgn0050287", "C5WLM7", "FBgn0050414", "Q9VR15", "FBgn0031619", "Q9W2C8", "FBgn0034661", "Q8IRK6", "FBgn0050288", "A1ZA44", "FBgn0050083", "Q9VK10", "FBgn0284244", "Q9VZS9", "FBgn0053160", "Q8IRK5", "FBgn0050289", "A1ZA38", "FBgn0050088", "Q9VA87", "FBgn0039759", "Q9VXC7", "FBgn0030775", "Q7KVM8", "FBgn0069056", "A0A4D6K1E7", "FBgn0039272", "Q9VA44", "FBgn0039798", "Q9VWD8", "FBgn0031058", "Q7KVM3", "FBgn0034666", "Q9V3Z2", "FBgn0037515" ] }, "reaction_10460409": { "compartment": "compartment_876", "id": "reaction_10460409", "reactome": "R-DME-1604368", "name": "Autocatalytic activation of bound proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460396" ], "products": [ "species_10460050", "species_10460406" ], "modifiers": [ [ "species_10460396", "catalyst" ] ], "additional_components": [ "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10460374": { "compartment": "compartment_984", "id": "reaction_10460374", "reactome": "R-DME-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460062" ], "products": [ "species_10460371", "species_10460055" ], "modifiers": [ [ "species_10460062", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460053": { "compartment": "compartment_984", "id": "reaction_10460053", "reactome": "R-DME-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460048" ], "products": [ "species_10460050", "species_10459266" ], "modifiers": [ [ "species_10460048", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460437": { "compartment": "compartment_984", "id": "reaction_10460437", "reactome": "R-DME-1604741", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460380" ], "products": [ "species_10460435", "species_10460422" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460403": { "compartment": "compartment_876", "id": "reaction_10460403", "reactome": "R-DME-1604360", "name": "Initial activation of proMMP2 by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460388" ], "products": [ "species_10460392", "species_10460396" ], "modifiers": [ [ "species_10460187", "catalyst" ], [ "species_10460401", "inhibitor" ] ], "additional_components": [ "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "FBgn0035049", "FBgn0026562" ] }, "reaction_10460433": { "compartment": "compartment_984", "id": "reaction_10460433", "reactome": "R-DME-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460422" ], "products": [ "species_10459254", "species_10460426" ], "modifiers": [ [ "species_10460422", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460369": { "compartment": "compartment_17963", "id": "reaction_10460369", "reactome": "R-DME-1602466", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460353" ], "products": [ "species_10460367" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9W122", "FBgn0035049", "Q9W122", "FBgn0035049", "FBgn0004509" ] }, "reaction_10460559": { "compartment": "compartment_17963", "id": "reaction_10460559", "reactome": "R-DME-1605825", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460367" ], "products": [ "species_10460557" ], "modifiers": [], "additional_components": [ "Q9W122", "FBgn0035049", "Q9W122", "FBgn0035049" ] }, "reaction_10460334": { "compartment": "compartment_984", "id": "reaction_10460334", "reactome": "R-DME-1602454", "name": "proMMP9 binds TIMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460224", "species_10452419" ], "products": [ "species_10460332" ], "modifiers": [], "additional_components": [ "FBgn0035049", "FBgn0025879", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10460460": { "compartment": "compartment_984", "id": "reaction_10460460", "reactome": "R-DME-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460380" ], "products": [ "species_10460439", "species_10460424" ], "modifiers": [ [ "species_10460457", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q9W122", "FBgn0035049" ] }, "reaction_10460394": { "compartment": "compartment_984", "id": "reaction_10460394", "reactome": "R-DME-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460386" ], "products": [ "species_10460048", "species_10460392" ], "modifiers": [ [ "species_10459252", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460231": { "compartment": "compartment_984", "id": "reaction_10460231", "reactome": "R-DME-1592436", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460224" ], "products": [ "species_10460226", "species_10460228" ], "modifiers": [ [ "species_10459252", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460390": { "compartment": "compartment_876", "id": "reaction_10460390", "reactome": "R-DME-1604350", "name": "MMP14:TIMP2 binds proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460386", "species_10460191" ], "products": [ "species_10460388" ], "modifiers": [], "additional_components": [ "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10460420": { "compartment": "compartment_984", "id": "reaction_10460420", "reactome": "R-DME-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460197" ], "products": [ "species_10460417", "species_10459256" ], "modifiers": [ [ "species_10460197", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460193": { "compartment": "compartment_876", "id": "reaction_10460193", "reactome": "R-DME-1592349", "name": "MMP14 (MT1-MMP) binds TIMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460187", "species_10460189" ], "products": [ "species_10460191" ], "modifiers": [], "additional_components": [ "FBgn0035049", "FBgn0025879", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10469030": { "compartment": "compartment_984", "id": "reaction_10469030", "reactome": "R-DME-3791319", "name": "NID1 degradation by MMP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465781" ], "products": [ "species_10469025", "species_10469027" ], "modifiers": [ [ "species_10459264", "catalyst" ] ], "additional_components": [ "FBgn0000119", "FBgn0000119", "FBgn0000119", "FBgn0035049" ] }, "reaction_10466181": { "compartment": "compartment_876", "id": "reaction_10466181", "reactome": "R-DME-2533950", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451" ], "products": [ "species_10459980" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "FBgn0035049" ] }, "reaction_10469045": { "compartment": "compartment_876", "id": "reaction_10469045", "reactome": "R-DME-3828025", "name": "DCN (decorin) degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465552" ], "products": [ "species_10466183", "species_10466185" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "FBgn0028872", "FBgn0035049" ] }, "reaction_10468964": { "compartment": "compartment_876", "id": "reaction_10468964", "reactome": "R-DME-3788061", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451" ], "products": [ "species_10468949" ], "modifiers": [ [ "species_10468961", "catalyst" ] ], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140" ] }, "reaction_10469043": { "compartment": "compartment_876", "id": "reaction_10469043", "reactome": "R-DME-3827958", "name": "E-cadherin degradation by MMP9, KLK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469032" ], "products": [ "species_10469040", "species_10469036" ], "modifiers": [ [ "species_10459272", "catalyst" ] ], "additional_components": [ "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "FBgn0035049" ] }, "reaction_10460002": { "compartment": "compartment_984", "id": "reaction_10460002", "reactome": "R-DME-1566981", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451" ], "products": [ "species_10459980" ], "modifiers": [ [ "species_10459999", "catalyst" ] ], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q9W122", "FBgn0035049" ] }, "reaction_10434812": { "compartment": "compartment_7660", "id": "reaction_10434812", "reactome": "R-DME-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434771", "species_10434653" ], "products": [ "species_10434773" ], "modifiers": [], "additional_components": [ "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10434778": { "compartment": "compartment_7660", "id": "reaction_10434778", "reactome": "R-DME-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434658", "species_10429250", "species_10431174" ], "products": [ "species_10434771", "species_10431174" ], "modifiers": [ [ "species_10434658", "catalyst" ] ], "additional_components": [ "FBgn0035026", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "FBgn0035026" ] }, "reaction_10434810": { "compartment": "compartment_7660", "id": "reaction_10434810", "reactome": "R-DME-113402", "name": "Formation of DSIF:NELF:early elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434773", "species_10434646", "species_30595" ], "products": [ "species_10434775", "species_30595" ], "modifiers": [], "additional_components": [ "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "species_110577", "species_113592", "species_29494", "species_29438" ] }, "reaction_10446741": { "compartment": "compartment_70101", "id": "reaction_10446741", "reactome": "R-DME-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446737", "species_10446693" ], "products": [ "species_10446739" ], "modifiers": [], "additional_components": [ "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "FBgn0030300", "Q9VYY8", "FBgn0030300", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019" ] }, "reaction_10487280": { "compartment": "compartment_70101", "id": "reaction_10487280", "reactome": "R-DME-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487278" ], "products": [ "species_29372", "species_10487272" ], "modifiers": [], "additional_components": [ "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_113592", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105" ] }, "reaction_10488352": { "compartment": "compartment_70101", "id": "reaction_10488352", "reactome": "R-DME-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488348", "species_10488332" ], "products": [ "species_10488350" ], "modifiers": [], "additional_components": [ "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927" ] }, "reaction_10487330": { "compartment": "compartment_70101", "id": "reaction_10487330", "reactome": "R-DME-6814409", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487328" ], "products": [ "species_29370", "species_10487289" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "FBgn0036519", "FBgn0036519", "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10488356": { "compartment": "compartment_70101", "id": "reaction_10488356", "reactome": "R-DME-8850534", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488354" ], "products": [ "species_10488332", "species_10487289" ], "modifiers": [], "additional_components": [ "Q9VUR7", "FBgn0036519", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "FBgn0036519" ] }, "reaction_10488360": { "compartment": "compartment_70101", "id": "reaction_10488360", "reactome": "R-DME-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488350" ], "products": [ "species_10446737", "species_10488358" ], "modifiers": [], "additional_components": [ "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W3J1", "FBgn0030011", "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927" ] }, "reaction_10487274": { "compartment": "compartment_70101", "id": "reaction_10487274", "reactome": "R-DME-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434577", "species_10446737" ], "products": [ "species_10487272" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105" ] }, "reaction_10488330": { "compartment": "compartment_70101", "id": "reaction_10488330", "reactome": "R-DME-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488328" ], "products": [ "species_10446737", "species_10487334" ], "modifiers": [], "additional_components": [ "P29829", "FBgn0004623", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9VUR7", "FBgn0036519", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "Q9VUR7", "FBgn0036519" ] }, "reaction_10487340": { "compartment": "compartment_70101", "id": "reaction_10487340", "reactome": "R-DME-6814418", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434560", "species_10487334" ], "products": [ "species_10487338" ], "modifiers": [], "additional_components": [ "P38040", "FBgn0004921", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "Q9VUR7", "FBgn0036519", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VUR7", "FBgn0036519" ] }, "reaction_10488364": { "compartment": "compartment_70101", "id": "reaction_10488364", "reactome": "R-DME-8850560", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487338", "species_10434215" ], "products": [ "species_10488362", "species_10487289" ], "modifiers": [], "additional_components": [ "P29829", "FBgn0004623", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VUR7", "FBgn0036519", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P38040", "FBgn0004921", "FBgn0036519" ] }, "reaction_10487293": { "compartment": "compartment_70101", "id": "reaction_10487293", "reactome": "R-DME-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487289", "species_10487272" ], "products": [ "species_10487291" ], "modifiers": [], "additional_components": [ "FBgn0036519", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9VUR7", "FBgn0036519" ] }, "reaction_10487295": { "compartment": "compartment_70101", "id": "reaction_10487295", "reactome": "R-DME-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487272" ], "products": [ "species_10487278", "species_29370" ], "modifiers": [], "additional_components": [ "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_113592", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105" ] }, "reaction_10435035": { "compartment": "compartment_70101", "id": "reaction_10435035", "reactome": "R-DME-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435028", "species_114520" ], "products": [ "species_10435030" ], "modifiers": [], "additional_components": [ "P29993", "FBgn0010051", "species_114520", "species_74016", "P29993", "FBgn0010051" ] }, "reaction_10448282": { "compartment": "compartment_876", "id": "reaction_10448282", "reactome": "R-DME-426209", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448278", "species_114519" ], "products": [ "species_10448280" ], "modifiers": [], "additional_components": [ "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "species_114519", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861" ] }, "reaction_10448164": { "compartment": "compartment_70101", "id": "reaction_10448164", "reactome": "R-DME-425861", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440788", "species_114519" ], "products": [ "species_10448162" ], "modifiers": [], "additional_components": [ "P83099", "FBgn0259680", "P13678", "FBgn0003093", "species_114519", "P83099", "FBgn0259680", "P13678", "FBgn0003093" ] }, "reaction_10448320": { "compartment": "compartment_70101", "id": "reaction_10448320", "reactome": "R-DME-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10448317", "catalyst" ] ], "additional_components": [ "Q7K579", "FBgn0020930", "A8JQ65", "FBgn0085413", "Q09103", "FBgn0261549", "Q01583", "FBgn0085390" ] }, "reaction_10492391": { "compartment": "compartment_7660", "id": "reaction_10492391", "reactome": "R-DME-8938231", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447242", "species_10489794" ], "products": [ "species_10492389" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617" ] }, "reaction_10435599": { "compartment": "compartment_70101", "id": "reaction_10435599", "reactome": "R-DME-156910", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435585", "species_10435590", "species_10435595" ], "products": [ "species_10435597" ], "modifiers": [], "additional_components": [ "FBgn0028737", "FBgn0032198", "FBgn0029176", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737" ] }, "reaction_10435616": { "compartment": "compartment_70101", "id": "reaction_10435616", "reactome": "R-DME-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10435612" ], "products": [ "species_10435614" ], "modifiers": [], "additional_components": [ "FBgn0000559", "P13060", "FBgn0000559", "species_29438" ] }, "reaction_10435606": { "compartment": "compartment_70101", "id": "reaction_10435606", "reactome": "R-DME-156913", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10435601", "species_10435597" ], "products": [ "species_10435603", "species_10435580" ], "modifiers": [ [ "species_10435597", "catalyst" ] ], "additional_components": [ "P08736", "FBgn0284245", "P05303", "FBgn0000557", "species_29420", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737", "species_29420", "P08736", "FBgn0284245", "P05303", "FBgn0000557", "species_29438", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737" ] }, "reaction_10498785": { "compartment": "compartment_7660", "id": "reaction_10498785", "reactome": "R-DME-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1254400", "species_10492512" ], "products": [ "species_10492514" ], "modifiers": [], "additional_components": [ "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "species_374146" ] }, "reaction_10492498": { "compartment": "compartment_7660", "id": "reaction_10492498", "reactome": "R-DME-8939201", "name": "ESR dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492488" ], "products": [ "species_10492496" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "species_374146", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10492518": { "compartment": "compartment_7660", "id": "reaction_10492518", "reactome": "R-DME-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492508", "species_1254400" ], "products": [ "species_10492510" ], "modifiers": [], "additional_components": [ "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "species_374146", "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592" ] }, "reaction_10497254": { "compartment": "compartment_7660", "id": "reaction_10497254", "reactome": "R-DME-9038029", "name": "27-hydroxysterol binds ESR1, ESR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445260", "species_9024328" ], "products": [ "species_10497252" ], "modifiers": [], "additional_components": [ "FBgn0035849", "species_9024328", "Q8WS79", "FBgn0035849" ] }, "reaction_10495875": { "compartment": "compartment_7660", "id": "reaction_10495875", "reactome": "R-DME-9008270", "name": "NCOA1 binds ESR1:estrogen:TGFA gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495867", "species_10440440" ], "products": [ "species_10495873" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "FBgn0041092", "M9ND53", "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974" ] }, "reaction_10495879": { "compartment": "compartment_7660", "id": "reaction_10495879", "reactome": "R-DME-9008285", "name": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495869", "species_10458126" ], "products": [ "species_10495877" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092", "FBgn0261617", "M9MS40", "FBgn0261617", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092" ] }, "reaction_10496935": { "compartment": "compartment_7660", "id": "reaction_10496935", "reactome": "R-DME-9023840", "name": "HATs and coactivators are recruited to the CTSD gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476674", "species_10496924", "species_10445380", "species_10465316", "species_10496931", "species_10458126", "species_10496929" ], "products": [ "species_10496933" ], "modifiers": [], "additional_components": [ "FBgn0041092", "species_374146", "Q8WS79", "FBgn0035849", "FBgn0037109", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "FBgn0029711", "FBgn0261617", "FBgn0029711", "Q9W4J8", "FBgn0029711", "M9MS40", "FBgn0261617", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "Q9VP05", "FBgn0037109", "species_374146", "Q8WS79", "FBgn0035849", "M9ND53", "FBgn0041092" ] }, "reaction_10496587": { "compartment": "compartment_7660", "id": "reaction_10496587", "reactome": "R-DME-9018499", "name": "ESR1:ESTG and EP300 are recruited to TFF3 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496583", "species_10458587", "species_10458126" ], "products": [ "species_10496585" ], "modifiers": [], "additional_components": [ "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "species_374146", "Q8WS79", "FBgn0035849", "FBgn0261617", "M9MS40", "FBgn0261617", "species_374146", "Q8WS79", "FBgn0035849", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223" ] }, "reaction_10496075": { "compartment": "compartment_7660", "id": "reaction_10496075", "reactome": "R-DME-9009526", "name": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496071", "species_10447247" ], "products": [ "species_10496073" ], "modifiers": [], "additional_components": [ "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "FBgn0037770", "Q9VH48", "FBgn0037770", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10496077": { "compartment": "compartment_7660", "id": "reaction_10496077", "reactome": "R-DME-9009533", "name": "TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431317", "species_10431112", "species_10496069" ], "products": [ "species_10496071" ], "modifiers": [], "additional_components": [ "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10496079": { "compartment": "compartment_7660", "id": "reaction_10496079", "reactome": "R-DME-9009536", "name": "DDX5 binds ESR1:estrogen:TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429510", "species_10496067" ], "products": [ "species_10496069" ], "modifiers": [], "additional_components": [ "FBgn0035720", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720" ] }, "reaction_10496081": { "compartment": "compartment_7660", "id": "reaction_10496081", "reactome": "R-DME-9009541", "name": "ESR1 binds to TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495863", "species_10496065" ], "products": [ "species_10496067" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974" ] }, "reaction_10496945": { "compartment": "compartment_7660", "id": "reaction_10496945", "reactome": "R-DME-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496941", "species_10496937" ], "products": [ "species_10496943" ], "modifiers": [], "additional_components": [ "Q9VH48", "FBgn0037770", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VGW7", "FBgn0037834", "M9MS40", "FBgn0261617", "M9ND53", "FBgn0041092", "Q960X4", "FBgn0026080", "Q9VTZ1", "FBgn0020388", "M9MS40", "FBgn0261617", "M9ND53", "FBgn0041092", "Q960X4", "FBgn0026080", "Q9VTZ1", "FBgn0020388", "Q9VH48", "FBgn0037770", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VGW7", "FBgn0037834" ] }, "reaction_10496947": { "compartment": "compartment_7660", "id": "reaction_10496947", "reactome": "R-DME-9023861", "name": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467587", "species_10496071" ], "products": [ "species_10496939" ], "modifiers": [], "additional_components": [ "FBgn0037834", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VGW7", "FBgn0037834" ] }, "reaction_10496213": { "compartment": "compartment_7660", "id": "reaction_10496213", "reactome": "R-DME-9012315", "name": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496205", "species_10496209" ], "products": [ "species_10496211" ], "modifiers": [], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855" ] }, "reaction_10496951": { "compartment": "compartment_7660", "id": "reaction_10496951", "reactome": "R-DME-9023884", "name": "NCOA1 recruits EP300 to TGFA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458126", "species_10495873" ], "products": [ "species_10496949" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9ND53", "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9MS40", "FBgn0261617" ] }, "reaction_10491863": { "compartment": "compartment_7660", "id": "reaction_10491863", "reactome": "R-DME-8931981", "name": "RUNX1 binds ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458587", "species_10489794" ], "products": [ "species_10491861" ], "modifiers": [], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10496218": { "compartment": "compartment_7660", "id": "reaction_10496218", "reactome": "R-DME-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10496211" ], "products": [ "species_113582", "species_10496215" ], "modifiers": [ [ "species_10496211", "catalyst" ] ], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855" ] }, "reaction_10495871": { "compartment": "compartment_7660", "id": "reaction_10495871", "reactome": "R-DME-9008258", "name": "NCOA3 binds ESR1:estrogen:TFGA gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476674", "species_10495867" ], "products": [ "species_10495869" ], "modifiers": [], "additional_components": [ "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092" ] }, "reaction_10496898": { "compartment": "compartment_876", "id": "reaction_10496898", "reactome": "R-DME-9021600", "name": "G-proteins dissociate from plasma-membrane estrogen receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496896" ], "products": [ "species_10465520", "species_10434579", "species_10437767" ], "modifiers": [], "additional_components": [ "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P20353", "FBgn0001104" ] }, "reaction_10496900": { "compartment": "compartment_876", "id": "reaction_10496900", "reactome": "R-DME-9021601", "name": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465520", "species_10445744" ], "products": [ "species_10496896" ], "modifiers": [], "additional_components": [ "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146" ] }, "reaction_10496903": { "compartment": "compartment_876", "id": "reaction_10496903", "reactome": "R-DME-9021609", "name": "ESR-associated SRC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496890", "species_113592" ], "products": [ "species_10465522", "species_29370" ], "modifiers": [ [ "species_10496890", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146" ] }, "reaction_10496875": { "compartment": "compartment_20699", "id": "reaction_10496875", "reactome": "R-DME-9021072", "name": "ZDHHC7, ZDHHC21 palmitoylate ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_10496865" ], "products": [ "species_10471012", "species_10496857", "species_76194" ], "modifiers": [ [ "species_10496872", "catalyst" ] ], "additional_components": [ "Q8WS79", "FBgn0035849", "Q8IQW5", "FBgn0031037", "Q8IQW5", "FBgn0031037", "FBgn0035849", "Q9I7L7", "FBgn0042133", "Q9VBM6", "FBgn0039368", "Q9W251", "FBgn0034729", "Q8IQN9", "FBgn0036670", "Q9VBM5", "FBgn0039369", "Q9VBM8", "FBgn0039366", "Q0IGS7", "FBgn0033815", "Q9VBM4", "FBgn0039370", "Q9VBM7", "FBgn0039367", "Q7K3T4", "FBgn0034057" ] }, "reaction_10497874": { "compartment": "compartment_876", "id": "reaction_10497874", "reactome": "R-DME-9634584", "name": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431840", "species_10497870", "species_10497757" ], "products": [ "species_10497872" ], "modifiers": [], "additional_components": [ "FBgn0015296", "P09208", "InR", "species_374146", "Q8WS79", "FBgn0035849", "species_374146", "Q8WS79", "FBgn0035849", "P09208", "InR", "Q9V3C8", "FBgn0015296" ] }, "reaction_10496888": { "compartment": "compartment_876", "id": "reaction_10496888", "reactome": "R-DME-9021170", "name": "Estrogen stimulates dimerization of plasma membrane estrogen receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496878", "species_374146" ], "products": [ "species_10496886" ], "modifiers": [], "additional_components": [ "FBgn0035849", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10497818": { "compartment": "compartment_70101", "id": "reaction_10497818", "reactome": "R-DME-9632182", "name": "PRMT1 methylates ESRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5279190", "species_10497809" ], "products": [ "species_10496878", "species_71285" ], "modifiers": [ [ "species_10497815", "catalyst" ], [ "species_374146", "catalyst" ] ], "additional_components": [ "FBgn0035849", "FBgn0035849", "FBgn0037834" ] }, "reaction_10497851": { "compartment": "compartment_876", "id": "reaction_10497851", "reactome": "R-DME-9633044", "name": "ESR binds STRN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496886", "species_10465518" ], "products": [ "species_10497013" ], "modifiers": [], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "FBgn0044323", "D3DML3", "FBgn0044323", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10496892": { "compartment": "compartment_876", "id": "reaction_10496892", "reactome": "R-DME-9021596", "name": "Membrane estrogen receptors bind SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465520", "species_10438881" ], "products": [ "species_10496890" ], "modifiers": [ [ "species_10437767", "catalyst" ], [ "species_10434579", "catalyst" ] ], "additional_components": [ "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "FBgn0262733", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10441093": { "compartment": "compartment_7660", "id": "reaction_10441093", "reactome": "R-DME-199298", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784" ] }, "reaction_10497837": { "compartment": "compartment_7660", "id": "reaction_10497837", "reactome": "R-DME-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497833" ], "products": [ "species_10497835" ], "modifiers": [ [ "species_10437629", "catalyst" ], [ "species_10440931", "catalyst" ] ], "additional_components": [ "FBgn0010316", "FBgn0010316", "FBgn0020497", "P40417", "FBgn0003256" ] }, "reaction_10497725": { "compartment": "compartment_7660", "id": "reaction_10497725", "reactome": "R-DME-9624526", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441099" ], "products": [ "species_113582", "species_10441113" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10497727": { "compartment": "compartment_7660", "id": "reaction_10497727", "reactome": "R-DME-9624527", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441113" ], "products": [ "species_10497563" ], "modifiers": [], "additional_components": [] }, "reaction_10497759": { "compartment": "compartment_876", "id": "reaction_10497759", "reactome": "R-DME-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10446693", "catalyst" ], [ "species_10497757", "catalyst" ] ], "additional_components": [ "FBgn0030300", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10497042": { "compartment": "compartment_7660", "id": "reaction_10497042", "reactome": "R-DME-9029551", "name": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497000", "species_10440440" ], "products": [ "species_10497040" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "FBgn0041092", "M9ND53", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633" ] }, "reaction_10496998": { "compartment": "compartment_7660", "id": "reaction_10496998", "reactome": "R-DME-9024326", "name": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024383", "species_10496994" ], "products": [ "species_10496996" ], "modifiers": [], "additional_components": [ "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122" ] }, "reaction_10497046": { "compartment": "compartment_7660", "id": "reaction_10497046", "reactome": "R-DME-9029561", "name": "NCOA1 recruits EP300 to the ABCA1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458126", "species_10497040" ], "products": [ "species_10497044" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9ND53", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "M9ND53", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "M9MS40", "FBgn0261617" ] }, "reaction_10497002": { "compartment": "compartment_7660", "id": "reaction_10497002", "reactome": "R-DME-9024334", "name": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496996" ], "products": [ "species_10496990", "species_10497000" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633" ] }, "reaction_10497054": { "compartment": "compartment_7660", "id": "reaction_10497054", "reactome": "R-DME-9029580", "name": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497050", "species_10440440" ], "products": [ "species_10497052" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "M9ND53", "FBgn0041092" ] }, "reaction_10474430": { "compartment": "compartment_70101", "id": "reaction_10474430", "reactome": "R-DME-5634104", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471595" ], "products": [ "species_10471616" ], "modifiers": [], "additional_components": [ "species_5334816", "Q8INK3", "FBgn0037913", "Q8INK3", "FBgn0037913", "species_5334816" ] }, "reaction_10471597": { "compartment": "compartment_70101", "id": "reaction_10471597", "reactome": "R-DME-5334827", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471593", "species_5334816" ], "products": [ "species_10471595" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_5334816", "Q8INK3", "FBgn0037913" ] }, "reaction_10442349": { "compartment": "compartment_5460", "id": "reaction_10442349", "reactome": "R-DME-203946", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428865", "species_113593" ], "products": [ "species_113581", "species_10442333" ], "modifiers": [ [ "species_10442338", "catalyst" ], [ "species_29362", "catalyst" ], [ "species_113559", "catalyst" ], [ "species_10441275", "catalyst" ], [ "species_113557", "inhibitor" ], [ "species_10442347", "inhibitor" ] ], "additional_components": [ "Q9VM14", "FBgn0283658", "species_113596", "Q9VVL7", "FBgn0036762", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "Q9VM14", "FBgn0283658", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "species_113596", "Q9VVL7", "FBgn0036762", "FBgn0017558", "species_5334816", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P91622", "FBgn0017558" ] }, "reaction_10441277": { "compartment": "compartment_70101", "id": "reaction_10441277", "reactome": "R-DME-200406", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549207", "species_200993" ], "products": [ "species_201034", "species_76194" ], "modifiers": [ [ "species_10441263", "catalyst" ], [ "species_10441275", "catalyst" ], [ "species_29508", "inhibitor" ] ], "additional_components": [ "FBgn0261862", "species_5334816", "P20153", "FBgn0003964", "P13055", "FBgn0000568" ] }, "reaction_10474428": { "compartment": "compartment_7660", "id": "reaction_10474428", "reactome": "R-DME-5634103", "name": "SUMO-CRABP2 dissociates from atRA:RAR:RXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471618" ], "products": [ "species_10474426", "species_10471614" ], "modifiers": [], "additional_components": [ "P13055", "FBgn0000568", "P20153", "FBgn0003964", "Q8INK3", "FBgn0037913", "species_5334816", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "species_5334816", "FBgn0037913" ] }, "reaction_10471620": { "compartment": "compartment_7660", "id": "reaction_10471620", "reactome": "R-DME-5334854", "name": "RAR:RXR binds SUMO-CRABP2:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471616", "species_10471612" ], "products": [ "species_10471618" ], "modifiers": [], "additional_components": [ "Q8INK3", "FBgn0037913", "species_5334816", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "Q8INK3", "FBgn0037913", "species_5334816" ] }, "reaction_10473631": { "compartment": "compartment_70101", "id": "reaction_10473631", "reactome": "R-DME-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471971", "species_5334816" ], "products": [ "species_10471973" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_5334816", "Q8INK3", "FBgn0037913" ] }, "reaction_10472006": { "compartment": "compartment_70101", "id": "reaction_10472006", "reactome": "R-DME-5362721", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30927", "species_29360" ], "products": [ "species_70106", "species_32737", "species_73473" ], "modifiers": [ [ "species_10465841", "catalyst" ] ], "additional_components": [ "FBgn0000056" ] }, "reaction_10472004": { "compartment": "compartment_70101", "id": "reaction_10472004", "reactome": "R-DME-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10472001", "catalyst" ] ], "additional_components": [ "P46415", "FBgn0011768", "species_1562550" ] }, "reaction_10472051": { "compartment": "compartment_70101", "id": "reaction_10472051", "reactome": "R-DME-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10472048", "catalyst" ] ], "additional_components": [ "Q9VE80", "FBgn0038610", "Q8SZ46", "FBgn0286852", "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043", "Q9VRJ4", "FBgn0035588" ] }, "reaction_10473201": { "compartment": "compartment_70101", "id": "reaction_10473201", "reactome": "R-DME-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10471968": { "compartment": "compartment_70101", "id": "reaction_10471968", "reactome": "R-DME-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10471965", "catalyst" ] ], "additional_components": [ "Q9VIG6", "FBgn0032910", "Q9VCR9", "FBgn0039043", "Q9VKB8", "FBgn0032405", "Q9W3K9", "FBgn0029994", "Q9VCS2", "FBgn0039040", "Q9VR28", "FBgn0031630", "P91615", "FBgn0000056" ] }, "reaction_10436933": { "compartment": "compartment_70101", "id": "reaction_10436933", "reactome": "R-DME-165162", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436925" ], "products": [ "species_10436930", "species_29370" ], "modifiers": [ [ "species_10433712", "catalyst" ] ], "additional_components": [ "FBgn0005198", "FBgn0005198", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10436948": { "compartment": "compartment_70101", "id": "reaction_10436948", "reactome": "R-DME-165182", "name": "Phosphorylation of complexed TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436942" ], "products": [ "species_10436946", "species_29370" ], "modifiers": [ [ "species_10433712", "catalyst" ] ], "additional_components": [ "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10436958": { "compartment": "compartment_17938", "id": "reaction_10436958", "reactome": "R-DME-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10436954" ], "products": [ "species_29420", "species_10436956" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29420", "Q9VND8", "Rheb", "species_29438" ] }, "reaction_10445901": { "compartment": "compartment_70101", "id": "reaction_10445901", "reactome": "R-DME-380949", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10441308" ], "products": [ "species_29372", "species_10441300" ], "modifiers": [ [ "species_10445898", "catalyst" ] ], "additional_components": [ "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VBF9", "FBgn0039421", "Q961C5", "FBgn0086361" ] }, "reaction_10450613": { "compartment": "compartment_876", "id": "reaction_10450613", "reactome": "R-DME-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040", "species_113592" ], "products": [ "species_29370", "species_10437109" ], "modifiers": [ [ "species_10445887", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10445892": { "compartment": "compartment_70101", "id": "reaction_10445892", "reactome": "R-DME-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441308", "species_76577" ], "products": [ "species_10445887" ], "modifiers": [], "additional_components": [ "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10445890": { "compartment": "compartment_70101", "id": "reaction_10445890", "reactome": "R-DME-380927", "name": "p-AMPK phosphorylates TSC1:TSC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436942" ], "products": [ "species_29370", "species_10445885" ], "modifiers": [ [ "species_10445887", "catalyst" ] ], "additional_components": [ "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10445906": { "compartment": "compartment_70101", "id": "reaction_10445906", "reactome": "R-DME-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040" ], "products": [ "species_29372", "species_10445903" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10445885", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317" ] }, "reaction_10474811": { "compartment": "compartment_70101", "id": "reaction_10474811", "reactome": "R-DME-5653974", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437032", "species_10437004" ], "products": [ "species_10437034" ], "modifiers": [], "additional_components": [ "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10475738": { "compartment": "compartment_17938", "id": "reaction_10475738", "reactome": "R-DME-5672843", "name": "AKT1S1 (PRAS40) binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040", "species_10437061" ], "products": [ "species_10437063" ], "modifiers": [], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "FBgn0267824", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10498482": { "compartment": "compartment_70101", "id": "reaction_10498482", "reactome": "R-DME-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678687", "species_10437068" ], "products": [ "species_10437070" ], "modifiers": [], "additional_components": [ "FBgn0013954", "P48375", "FBgn0013954" ] }, "reaction_10437111": { "compartment": "compartment_17938", "id": "reaction_10437111", "reactome": "R-DME-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437089", "species_113592" ], "products": [ "species_29370", "species_10437099" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10437059", "catalyst" ], [ "species_10437070", "inhibitor" ], [ "species_10437109", "inhibitor" ] ], "additional_components": [ "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472", "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P48375", "FBgn0013954", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691" ] }, "reaction_10437077": { "compartment": "compartment_70101", "id": "reaction_10437077", "reactome": "R-DME-165708", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437048" ], "products": [ "species_10430485", "species_10437046" ], "modifiers": [], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709" ] }, "reaction_10437122": { "compartment": "compartment_70101", "id": "reaction_10437122", "reactome": "R-DME-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430332" ], "products": [ "species_29370", "species_10437119" ], "modifiers": [ [ "species_10437099", "catalyst" ] ], "additional_components": [ "FBgn0261592", "FBgn0261592", "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472" ] }, "reaction_10437136": { "compartment": "compartment_70101", "id": "reaction_10437136", "reactome": "R-DME-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430497", "species_113592" ], "products": [ "species_29370", "species_10437134" ], "modifiers": [ [ "species_10437099", "catalyst" ] ], "additional_components": [ "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472" ] }, "reaction_10437072": { "compartment": "compartment_17938", "id": "reaction_10437072", "reactome": "R-DME-165692", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430525" ], "products": [ "species_29370", "species_10437048" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10437059", "catalyst" ], [ "species_10437063", "inhibitor" ], [ "species_10437070", "inhibitor" ] ], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P48375", "FBgn0013954" ] }, "reaction_10474809": { "compartment": "compartment_17938", "id": "reaction_10474809", "reactome": "R-DME-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437036", "species_10436975" ], "products": [ "species_10437038" ], "modifiers": [], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10475736": { "compartment": "compartment_17938", "id": "reaction_10475736", "reactome": "R-DME-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437059", "species_113592" ], "products": [ "species_29370", "species_10475733" ], "modifiers": [ [ "species_10437059", "catalyst" ] ], "additional_components": [ "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10474807": { "compartment": "compartment_70101", "id": "reaction_10474807", "reactome": "R-DME-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437030", "species_10437017" ], "products": [ "species_10437032" ], "modifiers": [], "additional_components": [ "species_29420", "Q7K519", "FBgn0033272", "Q9VHJ4", "FBgn0037647", "species_29438", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10474805": { "compartment": "compartment_17938", "id": "reaction_10474805", "reactome": "R-DME-5653936", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436992", "species_10436997", "species_10436982", "species_10437002", "species_10436987" ], "products": [ "species_10437004" ], "modifiers": [], "additional_components": [ "FBgn0032642", "FBgn0035469", "FBgn0036932", "FBgn0026090", "FBgn0034350", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642" ] }, "reaction_10494954": { "compartment": "compartment_70101", "id": "reaction_10494954", "reactome": "R-DME-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10437036", "catalyst" ] ], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10437042": { "compartment": "compartment_70101", "id": "reaction_10437042", "reactome": "R-DME-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436956", "species_10437038" ], "products": [ "species_10437040" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29438", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10475729": { "compartment": "compartment_17938", "id": "reaction_10475729", "reactome": "R-DME-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437057", "species_10432008" ], "products": [ "species_10437059" ], "modifiers": [], "additional_components": [ "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10445389": { "compartment": "compartment_17938", "id": "reaction_10445389", "reactome": "R-DME-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437063" ], "products": [ "species_10437057", "species_29370" ], "modifiers": [ [ "species_10441842", "catalyst" ] ], "additional_components": [ "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10438766": { "compartment": "compartment_17963", "id": "reaction_10438766", "reactome": "R-DME-177107", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437824" ], "products": [ "species_10437860" ], "modifiers": [], "additional_components": [ "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10437884": { "compartment": "compartment_17941", "id": "reaction_10437884", "reactome": "R-DME-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437880" ], "products": [ "species_10437882", "species_10437838" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "FBgn0025800" ] }, "reaction_10437893": { "compartment": "compartment_171062", "id": "reaction_10437893", "reactome": "R-DME-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437890", "species_113592" ], "products": [ "species_29370", "species_10437880" ], "modifiers": [ [ "species_10437890", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300" ] }, "reaction_10437826": { "compartment": "compartment_20699", "id": "reaction_10437826", "reactome": "R-DME-170844", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437814" ], "products": [ "species_10437824" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "FBgn0004509" ] }, "reaction_10437967": { "compartment": "compartment_70101", "id": "reaction_10437967", "reactome": "R-DME-173542", "name": "SMURF2 ubiquitinates SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437962", "species_10426987" ], "products": [ "species_10437960", "species_10437964" ], "modifiers": [ [ "species_10437962", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "Q9V853", "FBgn0029006", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0029006", "O96660", "FBgn0025800", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O96660", "FBgn0025800", "Q9V853", "FBgn0029006" ] }, "reaction_10465227": { "compartment": "compartment_70101", "id": "reaction_10465227", "reactome": "R-DME-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437964" ], "products": [], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10465225": { "compartment": "compartment_70101", "id": "reaction_10465225", "reactome": "R-DME-2176445", "name": "SMURF2 binds SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437960", "species_10437886" ], "products": [ "species_10437962" ], "modifiers": [], "additional_components": [ "FBgn0029006", "FBgn0025800", "O96660", "FBgn0025800", "Q9V853", "FBgn0029006" ] }, "reaction_10465352": { "compartment": "compartment_70101", "id": "reaction_10465352", "reactome": "R-DME-2187382", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465345" ], "products": [], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O96660", "FBgn0025800" ] }, "reaction_10465350": { "compartment": "compartment_70101", "id": "reaction_10465350", "reactome": "R-DME-2187375", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437888", "species_10456460" ], "products": [ "species_10465343" ], "modifiers": [], "additional_components": [ "FBgn0025800", "FBgn0027052", "Q9XYW6", "FBgn0027052", "O96660", "FBgn0025800" ] }, "reaction_10465365": { "compartment": "compartment_70101", "id": "reaction_10465365", "reactome": "R-DME-2187405", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465358", "species_10437838" ], "products": [ "species_10465360" ], "modifiers": [], "additional_components": [ "FBgn0030735", "FBgn0025800", "O96660", "FBgn0025800", "Q7YU03", "FBgn0030735" ] }, "reaction_10465348": { "compartment": "compartment_70101", "id": "reaction_10465348", "reactome": "R-DME-2187368", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10465343" ], "products": [ "species_10465345", "species_10456460" ], "modifiers": [ [ "species_10465343", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XYW6", "FBgn0027052", "O96660", "FBgn0025800", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O96660", "FBgn0025800", "FBgn0027052", "Q9XYW6", "FBgn0027052", "O96660", "FBgn0025800" ] }, "reaction_10465363": { "compartment": "compartment_70101", "id": "reaction_10465363", "reactome": "R-DME-2187401", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465360", "species_29356" ], "products": [ "species_29372", "species_10465358", "species_10437886" ], "modifiers": [ [ "species_10465360", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "Q7YU03", "FBgn0030735", "FBgn0030735", "FBgn0025800", "O96660", "FBgn0025800", "Q7YU03", "FBgn0030735" ] }, "reaction_10465037": { "compartment": "compartment_204883", "id": "reaction_10465037", "reactome": "R-DME-2160931", "name": "Disassembly of tight junctions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465035" ], "products": [], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V853", "FBgn0029006", "M9PBE1", "FBgn0032796", "P48148", "Rho1", "A1Z9X0", "FBgn0261854", "Q0KHR3", "FBgn0000163", "O97111", "FBgn0026192", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300" ] }, "reaction_10454143": { "compartment": "compartment_70101", "id": "reaction_10454143", "reactome": "R-DME-870479", "name": "USP9X (FAM) binds to ubiquitinated SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454130", "species_10454139" ], "products": [ "species_10454132" ], "modifiers": [], "additional_components": [ "FBgn0005632", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P55824", "FBgn0005632" ] }, "reaction_10454141": { "compartment": "compartment_7660", "id": "reaction_10454141", "reactome": "R-DME-870477", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454137" ], "products": [ "species_10454139" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O62609", "FBgn0011655", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655" ] }, "reaction_10465341": { "compartment": "compartment_7660", "id": "reaction_10465341", "reactome": "R-DME-2187330", "name": "PARP1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437946", "species_10465325" ], "products": [ "species_10465327" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0010247", "P35875", "FBgn0010247", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465339": { "compartment": "compartment_7660", "id": "reaction_10465339", "reactome": "R-DME-2187325", "name": "PARP1 ADP-ribosylates SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10465327" ], "products": [ "species_427497", "species_10465336", "species_10465325" ], "modifiers": [ [ "species_10465327", "catalyst" ] ], "additional_components": [ "P35875", "FBgn0010247", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "FBgn0010247", "P35875", "FBgn0010247", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10437976": { "compartment": "compartment_7660", "id": "reaction_10437976", "reactome": "R-DME-173545", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437946" ], "products": [], "modifiers": [ [ "species_10437973", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q9Y165", "FBgn0027609", "P25867", "eff" ] }, "reaction_10454135": { "compartment": "compartment_70101", "id": "reaction_10454135", "reactome": "R-DME-870437", "name": "USP9X (FAM) deubiquitinates SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10454132" ], "products": [ "species_10454130", "species_10437831", "species_10426987" ], "modifiers": [ [ "species_10454132", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P55824", "FBgn0005632", "FBgn0005632", "FBgn0011655", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P55824", "FBgn0005632" ] }, "reaction_10465265": { "compartment": "compartment_7660", "id": "reaction_10465265", "reactome": "R-DME-2179276", "name": "SMURF2 monoubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10465258" ], "products": [ "species_10437940", "species_10465256", "species_10465262" ], "modifiers": [ [ "species_10465258", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9V853", "FBgn0029006", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0011655", "FBgn0029006", "O96660", "FBgn0025800", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9V853", "FBgn0029006", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465294": { "compartment": "compartment_7660", "id": "reaction_10465294", "reactome": "R-DME-2186767", "name": "Degradation of ubiquitinated SKI/SKIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465292" ], "products": [], "modifiers": [], "additional_components": [ "Q00G30", "FBgn0085450", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11" ] }, "reaction_10442669": { "compartment": "compartment_7660", "id": "reaction_10442669", "reactome": "R-DME-209055", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10442662" ], "products": [ "species_113550", "species_10442660", "species_10437940", "species_10442664" ], "modifiers": [ [ "species_10442662", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421", "FBgn0011655", "FBgn0025800", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421" ] }, "reaction_10465260": { "compartment": "compartment_7660", "id": "reaction_10465260", "reactome": "R-DME-2179274", "name": "SMURF2 binds SMAD3 phosphorylated in the linker region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465235", "species_10465256" ], "products": [ "species_10465258" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0029006", "Q9V853", "FBgn0029006", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465356": { "compartment": "compartment_70101", "id": "reaction_10465356", "reactome": "R-DME-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442664" ], "products": [ "species_10437886" ], "modifiers": [], "additional_components": [ "FBgn0025800", "FBgn0025800" ] }, "reaction_10465354": { "compartment": "compartment_7660", "id": "reaction_10465354", "reactome": "R-DME-2187388", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442660", "species_10437946" ], "products": [ "species_10442662" ], "modifiers": [], "additional_components": [ "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421" ] }, "reaction_10465254": { "compartment": "compartment_7660", "id": "reaction_10465254", "reactome": "R-DME-2176503", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465250" ], "products": [], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465252": { "compartment": "compartment_7660", "id": "reaction_10465252", "reactome": "R-DME-2176502", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10465246" ], "products": [ "species_10465250", "species_10465244" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VVI3", "FBgn0259174", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0259174" ] }, "reaction_10465248": { "compartment": "compartment_7660", "id": "reaction_10465248", "reactome": "R-DME-2176491", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465235", "species_10465244" ], "products": [ "species_10465246" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0259174", "Q9VVI3", "FBgn0259174", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10464907": { "compartment": "compartment_7660", "id": "reaction_10464907", "reactome": "R-DME-2127257", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458009", "species_10437946" ], "products": [ "species_10464905" ], "modifiers": [], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10465242": { "compartment": "compartment_7660", "id": "reaction_10465242", "reactome": "R-DME-2176475", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437946" ], "products": [ "species_113582", "species_10465235" ], "modifiers": [ [ "species_10465239", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "P25008", "FBgn0004597", "Q9VT57", "FBgn0015618", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10465290": { "compartment": "compartment_7660", "id": "reaction_10465290", "reactome": "R-DME-2186643", "name": "MEN1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465286", "species_10437946" ], "products": [ "species_10465288" ], "modifiers": [], "additional_components": [ "FBgn0031885", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q9VM47", "FBgn0031885" ] }, "reaction_10464521": { "compartment": "compartment_70101", "id": "reaction_10464521", "reactome": "R-DME-2031355", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437844", "species_10464315" ], "products": [ "species_10464519" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q45VV3", "yki", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465320": { "compartment": "compartment_7660", "id": "reaction_10465320", "reactome": "R-DME-2187309", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465316", "species_10437946" ], "products": [ "species_10465318" ], "modifiers": [], "additional_components": [ "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364" ] }, "reaction_10471447": { "compartment": "compartment_13231", "id": "reaction_10471447", "reactome": "R-DME-5252001", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471443", "species_10429914" ], "products": [ "species_10471445" ], "modifiers": [], "additional_components": [ "Q9V3Q7", "FBgn0038690", "Q7KT77", "FBgn0053310", "Q24048", "FBgn0015777", "Q24046", "FBgn0015776", "M9PDX8", "FBgn0032946", "Q9VDY7", "FBgn0038691", "FBgn0004856", "P39736", "FBgn0004856", "Q9V3Q7", "FBgn0038690", "Q7KT77", "FBgn0053310", "Q24048", "FBgn0015777", "Q24046", "FBgn0015776", "M9PDX8", "FBgn0032946", "Q9VDY7", "FBgn0038691" ] }, "reaction_10464867": { "compartment": "compartment_70101", "id": "reaction_10464867", "reactome": "R-DME-2106579", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464519" ], "products": [ "species_10464865" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q45VV3", "yki", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10441485": { "compartment": "compartment_70101", "id": "reaction_10441485", "reactome": "R-DME-201422", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441476", "species_10437831" ], "products": [ "species_10441483" ], "modifiers": [], "additional_components": [ "FBgn0011648", "FBgn0011655", "O62609", "FBgn0011655", "P42003", "FBgn0011648" ] }, "reaction_10441565": { "compartment": "compartment_13231", "id": "reaction_10441565", "reactome": "R-DME-201472", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441483" ], "products": [ "species_10441493" ], "modifiers": [], "additional_components": [ "O62609", "FBgn0011655", "P42003", "FBgn0011648", "P42003", "FBgn0011648", "O62609", "FBgn0011655" ] }, "reaction_10441563": { "compartment": "compartment_984", "id": "reaction_10441563", "reactome": "R-DME-201457", "name": "BMP2 binds to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441506", "species_10441524" ], "products": [ "species_10441526" ], "modifiers": [], "additional_components": [ "P07713", "FBgn0000490", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "P07713", "FBgn0000490" ] }, "reaction_10441499": { "compartment": "compartment_7660", "id": "reaction_10441499", "reactome": "R-DME-201425", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441493" ], "products": [], "modifiers": [ [ "species_10437973", "catalyst" ] ], "additional_components": [ "P42003", "FBgn0011648", "O62609", "FBgn0011655", "Q9Y165", "FBgn0027609", "P25867", "eff" ] }, "reaction_10441561": { "compartment": "compartment_17941", "id": "reaction_10441561", "reactome": "R-DME-201453", "name": "Phospho-R-Smad1/5/8 dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441557" ], "products": [ "species_10441476", "species_10441559" ], "modifiers": [], "additional_components": [ "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716" ] }, "reaction_10441497": { "compartment": "compartment_7660", "id": "reaction_10441497", "reactome": "R-DME-201423", "name": "SKI complexes with the Smad complex, suppressing BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441493", "species_10437951" ], "products": [ "species_10441495" ], "modifiers": [], "additional_components": [ "P42003", "FBgn0011648", "O62609", "FBgn0011655", "FBgn0085450", "Q00G30", "FBgn0085450", "P42003", "FBgn0011648", "O62609", "FBgn0011655" ] }, "reaction_10441671": { "compartment": "compartment_70101", "id": "reaction_10441671", "reactome": "R-DME-201648", "name": "An anchoring protein, Endofin, recruits R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441555", "species_10441539", "species_10441544" ], "products": [ "species_10441567" ], "modifiers": [], "additional_components": [ "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "FBgn0011648", "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716" ] }, "reaction_10441958": { "compartment": "compartment_876", "id": "reaction_10441958", "reactome": "R-DME-202604", "name": "Formation of a heteromeric BMP receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441522", "species_10441515" ], "products": [ "species_10441524" ], "modifiers": [], "additional_components": [ "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179" ] }, "reaction_10441542": { "compartment": "compartment_70101", "id": "reaction_10441542", "reactome": "R-DME-201443", "name": "Type II receptor phosphorylates type I receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441526" ], "products": [ "species_10441539", "species_29370" ], "modifiers": [ [ "species_10441526", "catalyst" ] ], "additional_components": [ "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "P07713", "FBgn0000490", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "P07713", "FBgn0000490" ] }, "reaction_10441570": { "compartment": "compartment_876", "id": "reaction_10441570", "reactome": "R-DME-201476", "name": "Activated type I receptor phosphorylates R-Smad1/5/8 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441567" ], "products": [ "species_29370", "species_10441557" ], "modifiers": [ [ "species_10441567", "catalyst" ] ], "additional_components": [ "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716" ] }, "reaction_10441553": { "compartment": "compartment_70101", "id": "reaction_10441553", "reactome": "R-DME-201445", "name": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441544" ], "products": [], "modifiers": [ [ "species_10437960", "catalyst" ] ], "additional_components": [ "FBgn0011648", "FBgn0029006" ] }, "reaction_10457846": { "compartment": "compartment_876", "id": "reaction_10457846", "reactome": "R-DME-1181149", "name": "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10457836" ], "products": [ "species_10457843", "species_29370" ], "modifiers": [ [ "species_10457836", "catalyst" ] ], "additional_components": [ "O61643", "FBgn0024913", "A1Z7L8", "FBgn0011300", "O61643", "FBgn0024913", "A1Z7L8", "FBgn0011300", "O61643", "FBgn0024913", "A1Z7L8", "FBgn0011300" ] }, "reaction_10459937": { "compartment": "compartment_70101", "id": "reaction_10459937", "reactome": "R-DME-1549526", "name": "Phosphorylation of SMAD2/3 by Activin:Activin Receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437886" ], "products": [ "species_29370", "species_10437838" ], "modifiers": [ [ "species_10459934", "catalyst" ] ], "additional_components": [ "FBgn0025800", "FBgn0025800", "A1Z7L8", "FBgn0011300", "O61643", "FBgn0024913" ] }, "reaction_10493361": { "compartment": "compartment_7660", "id": "reaction_10493361", "reactome": "R-DME-8944349", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493357", "species_10468252" ], "products": [ "species_10493359" ], "modifiers": [], "additional_components": [ "Q8IMA8", "FBgn0085432", "P16371", "GRO", "P16371", "GRO", "Q8IMA8", "FBgn0085432" ] }, "reaction_10471580": { "compartment": "compartment_7660", "id": "reaction_10471580", "reactome": "R-DME-5334050", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468226", "species_10467421" ], "products": [ "species_10471578" ], "modifiers": [], "additional_components": [ "FBgn0085432", "FBgn0020496", "O46036", "FBgn0020496", "Q8IMA8", "FBgn0085432" ] }, "reaction_10470019": { "compartment": "compartment_7660", "id": "reaction_10470019", "reactome": "R-DME-4641229", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468236" ], "products": [ "species_10468252" ], "modifiers": [], "additional_components": [ "P16371", "GRO" ] }, "reaction_10440586": { "compartment": "compartment_70101", "id": "reaction_10440586", "reactome": "R-DME-195280", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440579" ], "products": [ "species_10440579" ], "modifiers": [], "additional_components": [ "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn" ] }, "reaction_10464922": { "compartment": "compartment_70101", "id": "reaction_10464922", "reactome": "R-DME-2130286", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464912", "species_10426987" ], "products": [ "species_10464916" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn" ] }, "reaction_10440607": { "compartment": "compartment_70101", "id": "reaction_10440607", "reactome": "R-DME-195300", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440594", "species_113592" ], "products": [ "species_29370", "species_10440570" ], "modifiers": [ [ "species_10440594", "catalyst" ] ], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_10440604": { "compartment": "compartment_70101", "id": "reaction_10440604", "reactome": "R-DME-195287", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440601" ], "products": [ "species_29370", "species_10440590" ], "modifiers": [ [ "species_10440601", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10440616": { "compartment": "compartment_70101", "id": "reaction_10440616", "reactome": "R-DME-195318", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440611", "species_113592" ], "products": [ "species_29370", "species_10440601" ], "modifiers": [ [ "species_10440611", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10440597": { "compartment": "compartment_70101", "id": "reaction_10440597", "reactome": "R-DME-195283", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440590" ], "products": [ "species_10440594", "species_29370" ], "modifiers": [ [ "species_10440590", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10440584": { "compartment": "compartment_70101", "id": "reaction_10440584", "reactome": "R-DME-195275", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440570" ], "products": [ "species_10440579", "species_29370" ], "modifiers": [ [ "species_10440570", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10464920": { "compartment": "compartment_70101", "id": "reaction_10464920", "reactome": "R-DME-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464916" ], "products": [ "species_10442677", "species_10464918", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10471110": { "compartment": "compartment_70101", "id": "reaction_10471110", "reactome": "R-DME-5229343", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441755" ], "products": [ "species_10440560", "species_29370" ], "modifiers": [ [ "species_10441755", "catalyst" ] ], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650" ] }, "reaction_10440613": { "compartment": "compartment_70101", "id": "reaction_10440613", "reactome": "R-DME-195304", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440560", "species_10440609" ], "products": [ "species_10440611" ], "modifiers": [], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10464914": { "compartment": "compartment_70101", "id": "reaction_10464914", "reactome": "R-DME-2130279", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440579", "species_10442677" ], "products": [ "species_10464912" ], "modifiers": [], "additional_components": [ "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn" ] }, "reaction_10469710": { "compartment": "compartment_70101", "id": "reaction_10469710", "reactome": "R-DME-4332363", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469702" ], "products": [ "species_10469697", "species_29370" ], "modifiers": [ [ "species_10469702", "catalyst" ] ], "additional_components": [ "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10469834": { "compartment": "compartment_70101", "id": "reaction_10469834", "reactome": "R-DME-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469828" ], "products": [ "species_10469832" ], "modifiers": [], "additional_components": [ "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_74016", "Q24214", "FBgn0015614", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_1222611", "species_1562550" ] }, "reaction_10469706": { "compartment": "compartment_70101", "id": "reaction_10469706", "reactome": "R-DME-4332359", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10449351" ], "products": [ "species_10469702" ], "modifiers": [ [ "species_10469704", "inhibitor" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10469736": { "compartment": "compartment_7660", "id": "reaction_10469736", "reactome": "R-DME-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469730" ], "products": [ "species_10469734" ], "modifiers": [], "additional_components": [ "A0A4D6K823", "FBgn0011817", "A0A4D6K823", "FBgn0011817" ] }, "reaction_10469751": { "compartment": "compartment_7660", "id": "reaction_10469751", "reactome": "R-DME-4411383", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10469738" ], "products": [ "species_113582", "species_10469748" ], "modifiers": [ [ "species_10469734", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q8IMA8", "FBgn0085432", "P18824", "arm", "A0A4D6K823", "FBgn0011817" ] }, "reaction_10469558": { "compartment": "compartment_876", "id": "reaction_10469558", "reactome": "R-DME-3965447", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469553" ], "products": [ "species_10469538", "species_10434579", "species_10469543" ], "modifiers": [], "additional_components": [ "P16378", "FBgn0001122", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "FBgn0001122" ] }, "reaction_10446854": { "compartment": "compartment_70101", "id": "reaction_10446854", "reactome": "R-DME-398040", "name": "Gbeta:gamma activation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10434175" ], "products": [ "species_10446852" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "FBgn0004611", "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10469830": { "compartment": "compartment_70101", "id": "reaction_10469830", "reactome": "R-DME-4551451", "name": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10464038", "species_10464071" ], "products": [ "species_29372", "species_10469828" ], "modifiers": [ [ "species_10464071", "catalyst" ] ], "additional_components": [ "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614" ] }, "reaction_10469556": { "compartment": "compartment_876", "id": "reaction_10469556", "reactome": "R-DME-3965444", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10469549" ], "products": [ "species_10469553", "species_29420" ], "modifiers": [ [ "species_10469549", "catalyst" ] ], "additional_components": [ "P16378", "FBgn0001122", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16378", "FBgn0001122", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16378", "FBgn0001122", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343" ] }, "reaction_10466948": { "compartment": "compartment_70101", "id": "reaction_10466948", "reactome": "R-DME-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10464021", "species_74016" ], "products": [ "species_10464071" ], "modifiers": [], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614" ] }, "reaction_10469700": { "compartment": "compartment_70101", "id": "reaction_10469700", "reactome": "R-DME-4332358", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469697", "species_113592" ], "products": [ "species_10434387", "species_29370", "species_10469695" ], "modifiers": [ [ "species_10469697", "catalyst" ] ], "additional_components": [ "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10446865": { "compartment": "compartment_70101", "id": "reaction_10446865", "reactome": "R-DME-398193", "name": "PLC beta-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10446852", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10469087": { "compartment": "compartment_70101", "id": "reaction_10469087", "reactome": "R-DME-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441719", "species_10469083" ], "products": [ "species_10469085" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29438", "P51140", "phospho-dsh" ] }, "reaction_10469101": { "compartment": "compartment_876", "id": "reaction_10469101", "reactome": "R-DME-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441768", "species_10469097" ], "products": [ "species_10469099" ], "modifiers": [], "additional_components": [ "P09615", "WG", "Q9VFX1", "FBgn0038134", "P40589", "FBgn0010453", "P18537", "FZ", "P09615", "WG", "Q9VFX1", "FBgn0038134", "P40589", "FBgn0010453", "P18537", "FZ", "P51140", "phospho-dsh" ] }, "reaction_10470350": { "compartment": "compartment_876", "id": "reaction_10470350", "reactome": "R-DME-5138432", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470343" ], "products": [ "species_29370", "species_10470345" ], "modifiers": [ [ "species_10470347", "catalyst" ] ], "additional_components": [ "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343" ] }, "reaction_10470362": { "compartment": "compartment_876", "id": "reaction_10470362", "reactome": "R-DME-5138441", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441761", "species_10470339" ], "products": [ "species_10470343" ], "modifiers": [], "additional_components": [ "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh" ] }, "reaction_10470360": { "compartment": "compartment_876", "id": "reaction_10470360", "reactome": "R-DME-5138433", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470354", "species_10470345", "species_10447483" ], "products": [ "species_10470358" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319" ] }, "reaction_10470341": { "compartment": "compartment_876", "id": "reaction_10470341", "reactome": "R-DME-5099899", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469528", "species_10468078" ], "products": [ "species_10470339" ], "modifiers": [], "additional_components": [ "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "FBgn0010194", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343" ] }, "reaction_10470402": { "compartment": "compartment_20592", "id": "reaction_10470402", "reactome": "R-DME-5138459", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470358" ], "products": [ "species_10470400", "species_10447483" ], "modifiers": [], "additional_components": [ "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P29742", "FBgn0000319", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120" ] }, "reaction_10470415": { "compartment": "compartment_876", "id": "reaction_10470415", "reactome": "R-DME-5140741", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470411", "species_10468078" ], "products": [ "species_10470413" ], "modifiers": [], "additional_components": [ "Q9VVX3", "FZ2", "P18537", "FZ", "Q24488", "FBgn0010407", "FBgn0010194", "P28466", "FBgn0010194", "Q9VVX3", "FZ2", "P18537", "FZ", "Q24488", "FBgn0010407" ] }, "reaction_10470429": { "compartment": "compartment_20592", "id": "reaction_10470429", "reactome": "R-DME-5140747", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470413" ], "products": [ "species_10470427" ], "modifiers": [ [ "species_10470354", "catalyst" ] ], "additional_components": [ "P28466", "FBgn0010194", "Q9VVX3", "FZ2", "P18537", "FZ", "Q24488", "FBgn0010407", "P28466", "FBgn0010194", "Q24488", "FBgn0010407", "Q9VVX3", "FZ2", "P18537", "FZ", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319" ] }, "reaction_10468030": { "compartment": "compartment_20699", "id": "reaction_10468030", "reactome": "R-DME-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468016", "species_10467932" ], "products": [ "species_10468028" ], "modifiers": [], "additional_components": [ "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "FBgn0036141", "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902" ] }, "reaction_10468026": { "compartment": "compartment_171062", "id": "reaction_10468026", "reactome": "R-DME-3247839", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467923", "species_10467928", "species_10467918" ], "products": [ "species_10467930" ], "modifiers": [], "additional_components": [ "FBgn0036141", "FBgn0038065", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q9VG51", "FBgn0038065", "Q95ST2", "FBgn0036141" ] }, "reaction_10468088": { "compartment": "compartment_20699", "id": "reaction_10468088", "reactome": "R-DME-3247849", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467934" ], "products": [ "species_10467928", "species_10467932", "species_10467918" ], "modifiers": [], "additional_components": [ "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q95ST2", "FBgn0036141", "Q9VG51", "FBgn0038065", "FBgn0038065", "FBgn0036141", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411" ] }, "reaction_10468023": { "compartment": "compartment_17963", "id": "reaction_10468023", "reactome": "R-DME-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467992" ], "products": [ "species_10468016" ], "modifiers": [ [ "species_10468021", "catalyst" ] ], "additional_components": [ "P28465", "FBgn0004360", "P28466", "FBgn0010194", "Q9VM26", "FBgn0031902", "P09615", "WG", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "FBgn0264389" ] }, "reaction_10468086": { "compartment": "compartment_171062", "id": "reaction_10468086", "reactome": "R-DME-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468032" ], "products": [ "species_10467923" ], "modifiers": [], "additional_components": [ "FBgn0036141", "FBgn0036141" ] }, "reaction_10468084": { "compartment": "compartment_20699", "id": "reaction_10468084", "reactome": "R-DME-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468028" ], "products": [ "species_10468058" ], "modifiers": [], "additional_components": [ "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141" ] }, "reaction_10468898": { "compartment": "compartment_876", "id": "reaction_10468898", "reactome": "R-DME-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468058" ], "products": [ "species_10468866" ], "modifiers": [], "additional_components": [ "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141", "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902" ] }, "reaction_10468082": { "compartment": "compartment_984", "id": "reaction_10468082", "reactome": "R-DME-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468058" ], "products": [ "species_10468080", "species_10468032" ], "modifiers": [], "additional_components": [ "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141", "P09615", "WG", "Q9VM25", "FBgn0031903", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "Q9VFX1", "FBgn0038134", "P40589", "FBgn0010453", "FBgn0036141" ] }, "reaction_10468896": { "compartment": "compartment_383505", "id": "reaction_10468896", "reactome": "R-DME-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468866" ], "products": [ "species_10468894" ], "modifiers": [], "additional_components": [ "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141" ] }, "reaction_10467936": { "compartment": "compartment_20699", "id": "reaction_10467936", "reactome": "R-DME-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467930" ], "products": [ "species_10467934" ], "modifiers": [], "additional_components": [ "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q9VG51", "FBgn0038065", "Q95ST2", "FBgn0036141", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q95ST2", "FBgn0036141", "Q9VG51", "FBgn0038065" ] }, "reaction_10444271": { "compartment": "compartment_70101", "id": "reaction_10444271", "reactome": "R-DME-354060", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444262", "species_10444267", "species_179856" ], "products": [ "species_10444269" ], "modifiers": [], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "FBgn0261811", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438" ] }, "reaction_10449918": { "compartment": "compartment_876", "id": "reaction_10449918", "reactome": "R-DME-443910", "name": "SHC1 dissociates from integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449914" ], "products": [ "species_10444292", "species_10431830" ], "modifiers": [], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "FBgn0015296" ] }, "reaction_10449916": { "compartment": "compartment_876", "id": "reaction_10449916", "reactome": "R-DME-443905", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449253" ], "products": [ "species_10449914" ], "modifiers": [], "additional_components": [ "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733" ] }, "reaction_10455337": { "compartment": "compartment_70101", "id": "reaction_10455337", "reactome": "R-DME-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10444300" ], "products": [ "species_29420", "species_10444262" ], "modifiers": [ [ "species_10446030", "catalyst" ] ], "additional_components": [ "P08645", "FBgn0004636", "species_29420", "P08645", "FBgn0004636", "species_29438", "FBgn0085421" ] }, "reaction_10444296": { "compartment": "compartment_70101", "id": "reaction_10444296", "reactome": "R-DME-354097", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444276", "species_10444269" ], "products": [ "species_10444278" ], "modifiers": [], "additional_components": [ "FBgn0260442", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442" ] }, "reaction_10449255": { "compartment": "compartment_70101", "id": "reaction_10449255", "reactome": "R-DME-432096", "name": "Activated integrin alphaIIb beta3 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431840", "species_10444292" ], "products": [ "species_10449253" ], "modifiers": [], "additional_components": [ "FBgn0015296", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296" ] }, "reaction_10444294": { "compartment": "compartment_876", "id": "reaction_10444294", "reactome": "R-DME-354077", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444290", "species_10444278" ], "products": [ "species_10444292" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733" ] }, "reaction_10464527": { "compartment": "compartment_70101", "id": "reaction_10464527", "reactome": "R-DME-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544" ], "products": [ "species_10458548" ], "modifiers": [], "additional_components": [] }, "reaction_10464525": { "compartment": "compartment_70101", "id": "reaction_10464525", "reactome": "R-DME-2032768", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464315" ], "products": [ "species_10464523" ], "modifiers": [], "additional_components": [] }, "reaction_10464317": { "compartment": "compartment_70101", "id": "reaction_10464317", "reactome": "R-DME-2028661", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10464315" ], "products": [ "species_10464309", "species_29370" ], "modifiers": [ [ "species_10464286", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464300": { "compartment": "compartment_70101", "id": "reaction_10464300", "reactome": "R-DME-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464261", "species_10464269" ], "products": [ "species_10464271" ], "modifiers": [], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464298": { "compartment": "compartment_70101", "id": "reaction_10464298", "reactome": "R-DME-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544", "species_113592" ], "products": [ "species_29370", "species_10464295" ], "modifiers": [ [ "species_10464281", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464313": { "compartment": "compartment_70101", "id": "reaction_10464313", "reactome": "R-DME-2028651", "name": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432016", "species_10464309" ], "products": [ "species_10464311" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "Q45VV3", "yki", "P92177", "14-3-3epsilon" ] }, "reaction_10464568": { "compartment": "compartment_70101", "id": "reaction_10464568", "reactome": "R-DME-2038398", "name": "KIBRA (WWC1) binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464564", "species_10464261" ], "products": [ "species_10464566" ], "modifiers": [], "additional_components": [ "FBgn0262127", "Q9VA38", "WTS", "Q9VFG8", "FBgn0262127" ] }, "reaction_10464693": { "compartment": "compartment_70101", "id": "reaction_10464693", "reactome": "R-DME-2060328", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10464315" ], "products": [ "species_10464309", "species_29370" ], "modifiers": [ [ "species_10464281", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464773": { "compartment": "compartment_70101", "id": "reaction_10464773", "reactome": "R-DME-2066299", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441761", "species_10464309" ], "products": [ "species_10464771" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P51140", "phospho-dsh" ] }, "reaction_10464306": { "compartment": "compartment_70101", "id": "reaction_10464306", "reactome": "R-DME-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432010", "species_10464284" ], "products": [ "species_10464304" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "Q45VV3", "yki", "P29310", "14-3-3zeta" ] }, "reaction_10464289": { "compartment": "compartment_70101", "id": "reaction_10464289", "reactome": "R-DME-2028583", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544", "species_113592" ], "products": [ "species_29370", "species_10464284" ], "modifiers": [ [ "species_10464286", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10440828": { "compartment": "compartment_70101", "id": "reaction_10440828", "reactome": "R-DME-198609", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436925" ], "products": [ "species_29370", "species_10440825" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0005198", "FBgn0005198" ] }, "reaction_10441258": { "compartment": "compartment_70101", "id": "reaction_10441258", "reactome": "R-DME-200143", "name": "AKT phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437061", "species_113592" ], "products": [ "species_29370", "species_10441256" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0267824", "FBgn0267824" ] }, "reaction_10493525": { "compartment": "compartment_70101", "id": "reaction_10493525", "reactome": "R-DME-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10456731" ], "products": [ "species_29370", "species_10493523" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0029152", "FBgn0029152" ] }, "reaction_10440837": { "compartment": "compartment_70101", "id": "reaction_10440837", "reactome": "R-DME-198611", "name": "AKT phosphorylates IKKalpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440832", "species_113592" ], "products": [ "species_10440835", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [] }, "reaction_10440852": { "compartment": "compartment_70101", "id": "reaction_10440852", "reactome": "R-DME-198621", "name": "AKT phosphorylates caspase-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434854", "species_113592" ], "products": [ "species_10440850", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404" ] }, "reaction_10465457": { "compartment": "compartment_70101", "id": "reaction_10465457", "reactome": "R-DME-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441880", "species_179856" ], "products": [ "species_10465455" ], "modifiers": [], "additional_components": [ "species_179856", "Q9W0V1", "Pdk1" ] }, "reaction_10441143": { "compartment": "compartment_876", "id": "reaction_10441143", "reactome": "R-DME-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440860", "species_10440877" ], "products": [ "species_10440879" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "FBgn0028978", "Q9V3Z1", "FBgn0028978", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10441141": { "compartment": "compartment_70101", "id": "reaction_10441141", "reactome": "R-DME-199425", "name": "PHLPP dephosphorylates S473 in AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10440775" ], "products": [ "species_29372", "species_10441125" ], "modifiers": [ [ "species_10441138", "catalyst" ] ], "additional_components": [ "Q0E8W8", "FBgn0035008", "species_266099" ] }, "reaction_10489428": { "compartment": "compartment_70101", "id": "reaction_10489428", "reactome": "R-DME-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440527" ], "products": [ "species_29370", "species_10489416" ], "modifiers": [ [ "species_10489425", "catalyst" ], [ "species_1806240", "catalyst" ] ], "additional_components": [] }, "reaction_10465529": { "compartment": "compartment_70101", "id": "reaction_10465529", "reactome": "R-DME-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465526", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "P91634", "Pi3K92E", "Q9XTN2", "chico", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "Q9NHV9", "FBgn0040068", "species_179838", "Q9VFI0", "FBgn0020299", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10487135": { "compartment": "compartment_70101", "id": "reaction_10487135", "reactome": "R-DME-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10440775" ], "products": [ "species_29372", "species_10446639" ], "modifiers": [ [ "species_10487126", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q8IN89", "FBgn0042693", "Q9VXB7", "FBgn0052568" ] }, "reaction_10493536": { "compartment": "compartment_70101", "id": "reaction_10493536", "reactome": "R-DME-8948832", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493530", "species_10426987" ], "products": [ "species_10488409" ], "modifiers": [ [ "species_10468669", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0036897" ] }, "reaction_10488401": { "compartment": "compartment_70101", "id": "reaction_10488401", "reactome": "R-DME-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441147" ], "products": [ "species_10488399", "species_29370" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10486309": { "compartment": "compartment_70101", "id": "reaction_10486309", "reactome": "R-DME-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10486306" ], "products": [ "species_10426987", "species_10441147" ], "modifiers": [ [ "species_10479271", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0035402" ] }, "reaction_10487829": { "compartment": "compartment_70101", "id": "reaction_10487829", "reactome": "R-DME-8847968", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441147", "species_10487825" ], "products": [ "species_10487827" ], "modifiers": [], "additional_components": [ "Q9V9J3", "phospho-Src42A", "Q7KMQ6", "Pten" ] }, "reaction_10493528": { "compartment": "compartment_70101", "id": "reaction_10493528", "reactome": "R-DME-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10441147" ], "products": [ "species_10486306" ], "modifiers": [ [ "species_10493523", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0029152" ] }, "reaction_10487835": { "compartment": "compartment_70101", "id": "reaction_10487835", "reactome": "R-DME-8847977", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487827" ], "products": [ "species_29370", "species_10487832", "species_10487825" ], "modifiers": [ [ "species_10487827", "catalyst" ] ], "additional_components": [ "Q9V9J3", "phospho-Src42A", "Q7KMQ6", "Pten", "Q9V9J3", "phospho-Src42A", "Q7KMQ6", "Pten" ] }, "reaction_10493533": { "compartment": "compartment_70101", "id": "reaction_10493533", "reactome": "R-DME-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441147", "species_29360" ], "products": [ "species_197277", "species_10493530" ], "modifiers": [ [ "species_10468679", "catalyst" ] ], "additional_components": [ "FBgn0027508" ] }, "reaction_10488413": { "compartment": "compartment_70101", "id": "reaction_10488413", "reactome": "R-DME-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488411" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q7KMQ6", "Pten", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10486303": { "compartment": "compartment_70101", "id": "reaction_10486303", "reactome": "R-DME-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10441147" ], "products": [ "species_10486296" ], "modifiers": [ [ "species_10486300", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XYW6", "FBgn0027052", "Q9Y0H4", "FBgn0003557", "Q9VVI3", "FBgn0259174", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10441198": { "compartment": "compartment_7660", "id": "reaction_10441198", "reactome": "R-DME-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441192" ], "products": [ "species_113582", "species_10441196" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0283472", "FBgn0283472" ] }, "reaction_10441208": { "compartment": "compartment_7660", "id": "reaction_10441208", "reactome": "R-DME-199863", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441203" ], "products": [ "species_113582", "species_10441206" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0014859", "FBgn0014859" ] }, "reaction_10441123": { "compartment": "compartment_7660", "id": "reaction_10441123", "reactome": "R-DME-199299", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441097" ], "products": [ "species_113582", "species_10441108" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10434463": { "compartment": "compartment_876", "id": "reaction_10434463", "reactome": "R-DME-111970", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10434429" ], "products": [ "species_29370", "species_10434460" ], "modifiers": [ [ "species_10434454", "catalyst" ] ], "additional_components": [ "FBgn0260798", "FBgn0260798", "species_74016", "P83099", "FBgn0259680", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10434389": { "compartment": "compartment_876", "id": "reaction_10434389", "reactome": "R-DME-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10434384", "catalyst" ], [ "species_10434387", "catalyst" ] ], "additional_components": [ "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10434456": { "compartment": "compartment_70101", "id": "reaction_10434456", "reactome": "R-DME-111966", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10434429" ], "products": [ "species_10434431" ], "modifiers": [ [ "species_10434454", "inhibitor" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "FBgn0260798", "P32865", "FBgn0260798", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_74016", "P83099", "FBgn0259680", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10434412": { "compartment": "compartment_70101", "id": "reaction_10434412", "reactome": "R-DME-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434407" ], "products": [ "species_10434407" ], "modifiers": [ [ "species_10434387", "catalyst" ] ], "additional_components": [ "B7YZV4", "FBgn0264815", "B7YZV4", "FBgn0264815", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10434410": { "compartment": "compartment_70101", "id": "reaction_10434410", "reactome": "R-DME-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10434407", "catalyst" ] ], "additional_components": [ "B7YZV4", "FBgn0264815" ] }, "reaction_10440803": { "compartment": "compartment_876", "id": "reaction_10440803", "reactome": "R-DME-198314", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440788", "species_113592" ], "products": [ "species_10440800", "species_29370" ], "modifiers": [ [ "species_10440788", "catalyst" ], [ "species_112275", "catalyst" ] ], "additional_components": [ "P83099", "FBgn0259680", "P13678", "FBgn0003093", "P13678", "FBgn0003093", "P83099", "FBgn0259680", "P83099", "FBgn0259680", "P13678", "FBgn0003093" ] }, "reaction_10497028": { "compartment": "compartment_876", "id": "reaction_10497028", "reactome": "R-DME-9029150", "name": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497022", "species_10497024" ], "products": [ "species_10497026" ], "modifiers": [], "additional_components": [ "Q9XYM0", "FBgn0024811", "O77086", "FBgn0259228", "Q9XTN2", "chico", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "Q9NHV9", "FBgn0040068", "Q08012", "FBgn0004638", "Q9NHV9", "FBgn0040068", "Q9XYM0", "FBgn0024811", "O77086", "FBgn0259228", "Q9XTN2", "chico", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296" ] }, "reaction_10496920": { "compartment": "compartment_876", "id": "reaction_10496920", "reactome": "R-DME-9021627", "name": "EPOR-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10496917", "catalyst" ] ], "additional_components": [ "Q9VZZ9", "FBgn0016794", "Q9XTN2", "chico", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10462046": { "compartment": "compartment_70101", "id": "reaction_10462046", "reactome": "R-DME-1912357", "name": "ITCH ubiquitinates DTX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462041", "species_10426987" ], "products": [ "species_10462043" ], "modifiers": [ [ "species_10462041", "catalyst" ] ], "additional_components": [ "Q9Y0H4", "FBgn0003557", "Q23985", "dx", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9Y0H4", "FBgn0003557", "Q23985", "dx", "Q9Y0H4", "FBgn0003557", "Q23985", "dx" ] }, "reaction_10462467": { "compartment": "compartment_70101", "id": "reaction_10462467", "reactome": "R-DME-1980125", "name": "ITCH binds DTX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462035", "species_10456470" ], "products": [ "species_10462041" ], "modifiers": [], "additional_components": [ "FBgn0003557", "Q9Y0H4", "FBgn0003557", "Q23985", "dx" ] }, "reaction_10462113": { "compartment": "compartment_70101", "id": "reaction_10462113", "reactome": "R-DME-1912382", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462097" ], "products": [ "species_10462106" ], "modifiers": [ [ "species_10462111", "inhibitor" ] ], "additional_components": [ "Q7KU08", "FBgn0051665", "Q7KU08", "FBgn0051665", "FBgn0029709" ] }, "reaction_10497378": { "compartment": "compartment_70101", "id": "reaction_10497378", "reactome": "R-DME-9604328", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10497365" ], "products": [ "species_10497371", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0051665", "FBgn0051665" ] }, "reaction_10471742": { "compartment": "compartment_17957", "id": "reaction_10471742", "reactome": "R-DME-5358336", "name": "P4HB forms mixed disulphides with Hh precursors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471730", "species_10468383" ], "products": [ "species_10471740" ], "modifiers": [], "additional_components": [ "FBgn0286818", "P54399", "FBgn0286818", "Q02936", "hh" ] }, "reaction_10471950": { "compartment": "compartment_12045", "id": "reaction_10471950", "reactome": "R-DME-5362441", "name": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471897", "species_10471918" ], "products": [ "species_10471920" ], "modifiers": [], "additional_components": [ "Q02936", "hh", "Q9VKC7", "FBgn0032398", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q02936", "hh", "Q9VKC7", "FBgn0032398" ] }, "reaction_10471948": { "compartment": "compartment_12045", "id": "reaction_10471948", "reactome": "R-DME-5362437", "name": "C-terminal Hh fragments are bound by lectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471895", "species_10471753" ], "products": [ "species_10471897" ], "modifiers": [], "additional_components": [ "FBgn0032398", "Q02936", "hh", "Q9VKC7", "FBgn0032398" ] }, "reaction_10471932": { "compartment": "compartment_12045", "id": "reaction_10471932", "reactome": "R-DME-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471920", "species_10426987" ], "products": [ "species_10471929" ], "modifiers": [ [ "species_10471920", "catalyst" ] ], "additional_components": [ "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q02936", "hh", "Q9VKC7", "FBgn0032398", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q9VKC7", "FBgn0032398", "Q02936", "hh", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q02936", "hh", "Q9VKC7", "FBgn0032398" ] }, "reaction_10471961": { "compartment": "compartment_70101", "id": "reaction_10471961", "reactome": "R-DME-5362459", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_10471929" ], "products": [ "species_10471952", "species_1132287", "species_29370", "species_10471895", "species_10471918" ], "modifiers": [ [ "species_10471929", "catalyst" ] ], "additional_components": [ "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q9VKC7", "FBgn0032398", "Q02936", "hh", "FBgn0032398", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q9VKC7", "FBgn0032398", "Q02936", "hh" ] }, "reaction_10471975": { "compartment": "compartment_876", "id": "reaction_10471975", "reactome": "R-DME-5362549", "name": "Hh-Np traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471763" ], "products": [ "species_10471934" ], "modifiers": [], "additional_components": [] }, "reaction_10471958": { "compartment": "compartment_70101", "id": "reaction_10471958", "reactome": "R-DME-5362448", "name": "Hh C-terminal fragments are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471952" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10471890": { "compartment": "compartment_17957", "id": "reaction_10471890", "reactome": "R-DME-5362386", "name": "Glycosylation of Hh", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471884" ], "products": [ "species_10471730" ], "modifiers": [], "additional_components": [] }, "reaction_10471999": { "compartment": "compartment_876", "id": "reaction_10471999", "reactome": "R-DME-5362553", "name": "NOTUM releases Hh-Np:GPC5 from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471944" ], "products": [ "species_10471991" ], "modifiers": [ [ "species_10471996", "catalyst" ] ], "additional_components": [ "Q02936", "hh", "Q24114", "dally", "Q24114", "dally", "Q02936", "hh", "FBgn0044028" ] }, "reaction_10471946": { "compartment": "compartment_876", "id": "reaction_10471946", "reactome": "R-DME-5362427", "name": "Hh-Np binds GPC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471942", "species_10471934" ], "products": [ "species_10471944" ], "modifiers": [], "additional_components": [ "Q02936", "hh", "Q24114", "dally" ] }, "reaction_10471760": { "compartment": "compartment_17957", "id": "reaction_10471760", "reactome": "R-DME-5358340", "name": "Autoproteolytic cleavage of Hh precursors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471740", "species_174672" ], "products": [ "species_10471745", "species_10471753", "species_10468383" ], "modifiers": [ [ "species_10471740", "catalyst" ] ], "additional_components": [ "P54399", "FBgn0286818", "Q02936", "hh", "FBgn0286818", "P54399", "FBgn0286818", "Q02936", "hh" ] }, "reaction_10471776": { "compartment": "compartment_17957", "id": "reaction_10471776", "reactome": "R-DME-5358343", "name": "HHAT palmitoylates Hh N-terminal fragment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471745", "species_5358339" ], "products": [ "species_10471763", "species_162743" ], "modifiers": [ [ "species_10471773", "catalyst" ] ], "additional_components": [] }, "reaction_10473197": { "compartment": "compartment_5263228", "id": "reaction_10473197", "reactome": "R-DME-5610767", "name": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472996" ], "products": [ "species_10473138" ], "modifiers": [ [ "species_10473149", "catalyst" ], [ "species_10473166", "catalyst" ], [ "species_10473195", "catalyst" ] ], "additional_components": [ "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "FBgn0030395", "Q9VPH0", "in", "O16868", "fuz", "Q7KRS6", "FBgn0016919", "Q9VRK9", "FBgn0004380", "Q9W040", "FBgn0035317", "Q9VQS5", "FBgn0031550", "Q9VMC0", "FBgn0031829" ] }, "reaction_10473035": { "compartment": "compartment_18730", "id": "reaction_10473035", "reactome": "R-DME-5610726", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473031", "species_10473003" ], "products": [ "species_10473033" ], "modifiers": [], "additional_components": [ "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264", "FBgn0015721", "Q86PC9", "FBgn0015721", "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264" ] }, "reaction_10473099": { "compartment": "compartment_5263232", "id": "reaction_10473099", "reactome": "R-DME-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473095", "species_30389" ], "products": [ "species_10473097", "species_10472975" ], "modifiers": [], "additional_components": [ "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P16905", "FBgn0259243", "P81900", "FBgn0022382", "species_30389", "P16905", "FBgn0259243", "P81900", "FBgn0022382", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10473127": { "compartment": "compartment_24337", "id": "reaction_10473127", "reactome": "R-DME-5610763", "name": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473117" ], "products": [ "species_10473121" ], "modifiers": [ [ "species_10473125", "inhibitor" ] ], "additional_components": [ "P91682", "phospho-smo", "P91682", "phospho-smo" ] }, "reaction_10472998": { "compartment": "compartment_70101", "id": "reaction_10472998", "reactome": "R-DME-5610723", "name": "GLI proteins bind SUFU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472994", "species_10472988" ], "products": [ "species_10472996" ], "modifiers": [], "additional_components": [ "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355" ] }, "reaction_10473083": { "compartment": "compartment_70101", "id": "reaction_10473083", "reactome": "R-DME-5610746", "name": "SCF(beta-TrCP) ubiquitinates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473046", "species_10426987" ], "products": [ "species_10473081" ], "modifiers": [ [ "species_10442677", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10472986": { "compartment": "compartment_70101", "id": "reaction_10472986", "reactome": "R-DME-5610722", "name": "CK1 phosphorylates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472965", "species_113592" ], "products": [ "species_29370", "species_10472983" ], "modifiers": [ [ "species_10440489", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650" ] }, "reaction_10473048": { "compartment": "compartment_70101", "id": "reaction_10473048", "reactome": "R-DME-5610732", "name": "GSK3 phosphorylates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10472983" ], "products": [ "species_29370", "species_10473046" ], "modifiers": [ [ "species_10440540", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "P83101", "FBgn0046332", "P18431", "sgg" ] }, "reaction_10473107": { "compartment": "compartment_70101", "id": "reaction_10473107", "reactome": "R-DME-5610754", "name": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473081" ], "products": [ "species_10472994", "species_10473101" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0005355", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10472978": { "compartment": "compartment_5263232", "id": "reaction_10472978", "reactome": "R-DME-5610720", "name": "PKA phosphorylates GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10472956" ], "products": [ "species_29370", "species_10472965" ], "modifiers": [ [ "species_10472975", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10473042": { "compartment": "compartment_876", "id": "reaction_10473042", "reactome": "R-DME-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10473039", "catalyst" ] ], "additional_components": [ "species_29926" ] }, "reaction_10473105": { "compartment": "compartment_70101", "id": "reaction_10473105", "reactome": "R-DME-5610752", "name": "GLI3R translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473101" ], "products": [ "species_10473103" ], "modifiers": [], "additional_components": [] }, "reaction_10473168": { "compartment": "compartment_5263232", "id": "reaction_10473168", "reactome": "R-DME-5610766", "name": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473138" ], "products": [ "species_10473144" ], "modifiers": [ [ "species_10473149", "catalyst" ], [ "species_10473156", "catalyst" ], [ "species_10473166", "catalyst" ] ], "additional_components": [ "P19538", "ci", "Q9VG38", "FBgn0005355", "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0030395", "Q0E8P6", "FBgn0023096", "Q9VSJ6", "FBgn0265102", "Q9VPH0", "in", "O16868", "fuz" ] }, "reaction_10474463": { "compartment": "compartment_5263228", "id": "reaction_10474463", "reactome": "R-DME-5635843", "name": "GLI translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474454" ], "products": [ "species_10474442" ], "modifiers": [], "additional_components": [] }, "reaction_10474461": { "compartment": "compartment_5263228", "id": "reaction_10474461", "reactome": "R-DME-5635842", "name": "ULK3 phosphorylates GLI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5632460", "species_10473130" ], "products": [ "species_5632457", "species_10474454" ], "modifiers": [ [ "species_10474435", "catalyst" ] ], "additional_components": [ "FBgn0037679" ] }, "reaction_10474491": { "compartment": "compartment_7660", "id": "reaction_10474491", "reactome": "R-DME-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474489" ], "products": [ "species_10427430", "species_10474487" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10474521": { "compartment": "compartment_70101", "id": "reaction_10474521", "reactome": "R-DME-5635868", "name": "ub-GLI is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474512" ], "products": [ "species_10426987", "species_10473055" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10474519": { "compartment": "compartment_261122", "id": "reaction_10474519", "reactome": "R-DME-5635865", "name": "SMURF1/2 dissociates from ub-PTCH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474517" ], "products": [ "species_10474372", "species_10437960" ], "modifiers": [], "additional_components": [ "Q9V853", "FBgn0029006", "P18502", "ptc", "FBgn0029006" ] }, "reaction_10474515": { "compartment": "compartment_70101", "id": "reaction_10474515", "reactome": "R-DME-5635864", "name": "NUMB:ITCH ubiquitinates GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474506", "species_10426987" ], "products": [ "species_10474512" ], "modifiers": [ [ "species_10474506", "catalyst" ] ], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci" ] }, "reaction_10474363": { "compartment": "compartment_261122", "id": "reaction_10474363", "reactome": "R-DME-5632652", "name": "Hh-Npp binds CDON and PTCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474355", "species_10473125", "species_10444875" ], "products": [ "species_10474361" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "P18502", "ptc", "Q02936", "hh" ] }, "reaction_10474508": { "compartment": "compartment_70101", "id": "reaction_10474508", "reactome": "R-DME-5635861", "name": "NUMB:ITCH binds GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472988", "species_10473055" ], "products": [ "species_10474506" ], "modifiers": [], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci" ] }, "reaction_10474376": { "compartment": "compartment_261122", "id": "reaction_10474376", "reactome": "R-DME-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474372" ], "products": [ "species_10474374" ], "modifiers": [], "additional_components": [] }, "reaction_10474504": { "compartment": "compartment_7660", "id": "reaction_10474504", "reactome": "R-DME-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10474493" ], "products": [ "species_10474489" ], "modifiers": [ [ "species_10474493", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci" ] }, "reaction_10474439": { "compartment": "compartment_18730", "id": "reaction_10474439", "reactome": "R-DME-5635839", "name": "ULK3:SUFU dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474437" ], "products": [ "species_10473136", "species_10474435" ], "modifiers": [], "additional_components": [ "Q9VHF6", "FBgn0037679", "Q9VG38", "FBgn0005355", "FBgn0005355", "FBgn0037679" ] }, "reaction_10474500": { "compartment": "compartment_7660", "id": "reaction_10474500", "reactome": "R-DME-5635855", "name": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474450", "species_10474487" ], "products": [ "species_10474493" ], "modifiers": [ [ "species_10474498", "catalyst" ] ], "additional_components": [ "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "FBgn0039201" ] }, "reaction_10474467": { "compartment": "compartment_7660", "id": "reaction_10474467", "reactome": "R-DME-5635845", "name": "GLI proteins bind CDC73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474448", "species_10434726" ], "products": [ "species_10474465" ], "modifiers": [], "additional_components": [ "FBgn0037657", "Q9VHI1", "FBgn0037657", "P19538", "ci" ] }, "reaction_10442699": { "compartment": "compartment_70101", "id": "reaction_10442699", "reactome": "R-DME-209536", "name": "IkB is ubiquitinated and degraded", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10437421" ], "products": [ "species_10442697" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q03017", "phospho-cact", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10440308": { "compartment": "compartment_13231", "id": "reaction_10440308", "reactome": "R-DME-193691", "name": "NF-kB migrates to the nucleus and turns on transcription", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10440364": { "compartment": "compartment_876", "id": "reaction_10440364", "reactome": "R-DME-193696", "name": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440360" ], "products": [ "species_10434904", "species_10440362" ], "modifiers": [], "additional_components": [ "Q9VW59", "RhoGDI", "P48148", "Rho1", "species_29420", "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476", "P48148", "Rho1", "species_29420", "Q9VW59", "RhoGDI", "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476" ] }, "reaction_10440455": { "compartment": "compartment_876", "id": "reaction_10440455", "reactome": "R-DME-194518", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434904" ], "products": [ "species_10434906" ], "modifiers": [ [ "species_10440452", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "FBgn0050440" ] }, "reaction_10496236": { "compartment": "compartment_876", "id": "reaction_10496236", "reactome": "R-DME-9012761", "name": "The p75NTR:NgR:MDGI binds RHOA-GDI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440358", "species_10440314" ], "products": [ "species_10440360" ], "modifiers": [], "additional_components": [ "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476", "Q9VW59", "RhoGDI", "P48148", "Rho1", "species_29420", "Q9VW59", "RhoGDI", "P48148", "Rho1", "species_29420", "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476" ] }, "reaction_10444395": { "compartment": "compartment_984", "id": "reaction_10444395", "reactome": "R-DME-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10444389" ], "products": [ "species_10444393" ], "modifiers": [], "additional_components": [ "FBgn0019985", "P91685", "FBgn0019985", "species_210382" ] }, "reaction_10497512": { "compartment": "compartment_984", "id": "reaction_10497512", "reactome": "R-DME-9611839", "name": "3-agonists bind ADRB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9611836", "species_10445401" ], "products": [ "species_10497510" ], "modifiers": [], "additional_components": [ "FBgn0039419", "Q9VBG4", "FBgn0039419" ] }, "reaction_10497514": { "compartment": "compartment_984", "id": "reaction_10497514", "reactome": "R-DME-9611852", "name": "ADRB3 bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10445401" ], "products": [ "species_10445403" ], "modifiers": [ [ "species_10497510", "catalyst" ], [ "species_10497386", "inhibitor" ] ], "additional_components": [ "CHEBI:28918", "species_351597", "FBgn0039419", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "Q9VBG4", "FBgn0039419", "Q9VBG4", "FBgn0039419" ] }, "reaction_10497388": { "compartment": "compartment_984", "id": "reaction_10497388", "reactome": "R-DME-9609310", "name": "-blockers bind ADRB1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9609307", "species_10445401" ], "products": [ "species_10497386" ], "modifiers": [], "additional_components": [ "FBgn0039419", "Q9VBG4", "FBgn0039419" ] }, "reaction_10446674": { "compartment": "compartment_984", "id": "reaction_10446674", "reactome": "R-DME-390663", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10445692" ], "products": [ "species_10445696" ], "modifiers": [], "additional_components": [ "CHEBI:28918", "species_351597", "FBgn0004514", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10446680": { "compartment": "compartment_984", "id": "reaction_10446680", "reactome": "R-DME-390846", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380873", "species_10445685" ], "products": [ "species_10445687" ], "modifiers": [], "additional_components": [ "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873" ] }, "reaction_10446678": { "compartment": "compartment_984", "id": "reaction_10446678", "reactome": "R-DME-390835", "name": "DRD1,5 bind DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445408", "species_380873" ], "products": [ "species_10445412" ], "modifiers": [], "additional_components": [ "FBgn0038063", "species_380873", "Q4LBB9", "FBgn0038063" ] }, "reaction_10498330": { "compartment": "compartment_984", "id": "reaction_10498330", "reactome": "R-DME-9656244", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380873", "species_10498326" ], "products": [ "species_10498328" ], "modifiers": [], "additional_components": [ "FBgn0053517", "Q8IS44", "FBgn0053517", "species_380873" ] }, "reaction_10446686": { "compartment": "compartment_984", "id": "reaction_10446686", "reactome": "R-DME-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445424", "species_114523" ], "products": [ "species_10445426" ], "modifiers": [], "additional_components": [ "P20905", "FBgn0004573", "P41596", "FBgn0011582", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582" ] }, "reaction_10446684": { "compartment": "compartment_984", "id": "reaction_10446684", "reactome": "R-DME-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445666", "species_114523" ], "products": [ "species_10445668" ], "modifiers": [], "additional_components": [ "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_114523", "P28285", "FBgn0004168", "P28286", "FBgn0263116" ] }, "reaction_10498659": { "compartment": "compartment_984", "id": "reaction_10498659", "reactome": "R-DME-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498655", "species_114523" ], "products": [ "species_10498657" ], "modifiers": [], "additional_components": [ "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_114523", "P28285", "FBgn0004168", "P28286", "FBgn0263116" ] }, "reaction_10446676": { "compartment": "compartment_984", "id": "reaction_10446676", "reactome": "R-DME-390673", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445698", "species_372533" ], "products": [ "species_10445702" ], "modifiers": [], "additional_components": [ "FBgn0000037", "species_372533", "P16395", "FBgn0000037" ] }, "reaction_10446672": { "compartment": "compartment_984", "id": "reaction_10446672", "reactome": "R-DME-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445550", "species_372533" ], "products": [ "species_10445556" ], "modifiers": [], "additional_components": [ "FBgn0000037", "species_372533", "P16395", "FBgn0000037" ] }, "reaction_10446688": { "compartment": "compartment_984", "id": "reaction_10446688", "reactome": "R-DME-391211", "name": "Trace amine-associated receptors can bind trace amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445431", "species_391200" ], "products": [ "species_10445445" ], "modifiers": [], "additional_components": [ "FBgn0029909", "species_391200", "Q9W3V5", "FBgn0029909" ] }, "reaction_10447672": { "compartment": "compartment_984", "id": "reaction_10447672", "reactome": "R-DME-419861", "name": "Melanospin is stimulated by light", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419777", "species_10445561" ], "products": [ "species_10445563" ], "modifiers": [], "additional_components": [ "FBgn0019940", "O01668", "FBgn0019940", "species_419777" ] }, "reaction_10446747": { "compartment": "compartment_984", "id": "reaction_10446747", "reactome": "R-DME-391375", "name": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445459", "species_10445450" ], "products": [ "species_10445461" ], "modifiers": [], "additional_components": [ "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "FBgn0016650", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368" ] }, "reaction_10447588": { "compartment": "compartment_984", "id": "reaction_10447588", "reactome": "R-DME-418925", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83908", "species_10445466" ], "products": [ "species_10445470" ], "modifiers": [], "additional_components": [ "FBgn0039747", "species_83908", "Q9VAA2", "FBgn0039747" ] }, "reaction_10447586": { "compartment": "compartment_984", "id": "reaction_10447586", "reactome": "R-DME-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445704", "species_83908" ], "products": [ "species_10445708" ], "modifiers": [], "additional_components": [ "FBgn0039747", "species_83908", "Q9VAA2", "FBgn0039747" ] }, "reaction_10450073": { "compartment": "compartment_984", "id": "reaction_10450073", "reactome": "R-DME-444654", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444840", "species_10445494" ], "products": [ "species_10445496" ], "modifiers": [], "additional_components": [ "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "FBgn0039747", "Q9VAA2", "FBgn0039747", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755" ] }, "reaction_10446753": { "compartment": "compartment_984", "id": "reaction_10446753", "reactome": "R-DME-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_416911", "species_10445718" ], "products": [ "species_10445720" ], "modifiers": [], "additional_components": [ "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429" ] }, "reaction_10498546": { "compartment": "compartment_984", "id": "reaction_10498546", "reactome": "R-DME-9690439", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445565", "species_416372" ], "products": [ "species_10445567" ], "modifiers": [ [ "species_10498535", "inhibitor" ] ], "additional_components": [ "FBgn0039595", "species_266074", "species_266013", "species_266033", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "Q9NBC8", "FBgn0039595" ] }, "reaction_10498537": { "compartment": "compartment_984", "id": "reaction_10498537", "reactome": "R-DME-9684627", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9684615", "species_10445565" ], "products": [ "species_10498535" ], "modifiers": [], "additional_components": [ "FBgn0039595", "Q9NBC8", "FBgn0039595" ] }, "reaction_10446757": { "compartment": "compartment_984", "id": "reaction_10446757", "reactome": "R-DME-391943", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445569", "species_416372" ], "products": [ "species_10445571" ], "modifiers": [], "additional_components": [ "FBgn0039595", "species_266074", "species_266013", "species_266033", "species_266074", "species_266013", "species_266033", "Q9NBC8", "FBgn0039595" ] }, "reaction_10446755": { "compartment": "compartment_984", "id": "reaction_10446755", "reactome": "R-DME-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445573", "species_416436" ], "products": [ "species_10445577" ], "modifiers": [], "additional_components": [ "FBgn0039595", "species_416436", "Q9NBC8", "FBgn0039595" ] }, "reaction_10447656": { "compartment": "compartment_984", "id": "reaction_10447656", "reactome": "R-DME-419334", "name": "Melatonin receptors can bind melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419339", "species_10445738" ], "products": [ "species_10445740" ], "modifiers": [], "additional_components": [ "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339" ] }, "reaction_10450092": { "compartment": "compartment_984", "id": "reaction_10450092", "reactome": "R-DME-444879", "name": "Relaxin receptor 2 binds relaxin 2 and INSL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445490", "species_10445482" ], "products": [ "species_10445492" ], "modifiers": [], "additional_components": [ "Q9VT53", "ILP4 alpha chain", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain" ] }, "reaction_10497587": { "compartment": "compartment_984", "id": "reaction_10497587", "reactome": "R-DME-9615249", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9615246", "species_10444647" ], "products": [ "species_10444713" ], "modifiers": [], "additional_components": [ "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632" ] }, "reaction_10444715": { "compartment": "compartment_984", "id": "reaction_10444715", "reactome": "R-DME-374173", "name": "AGT(34-41) binds to AGTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444709", "species_10444647" ], "products": [ "species_10444711" ], "modifiers": [ [ "species_10444713", "inhibitor" ] ], "additional_components": [ "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632" ] }, "reaction_10497589": { "compartment": "compartment_984", "id": "reaction_10497589", "reactome": "R-DME-9615348", "name": "AGT(34-41) binds to AGTR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445652", "species_10444709" ], "products": [ "species_10445654" ], "modifiers": [], "additional_components": [ "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9W533", "FBgn0025632" ] }, "reaction_10481289": { "compartment": "compartment_876", "id": "reaction_10481289", "reactome": "R-DME-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_417891" ], "products": [ "species_109277", "species_6797635" ], "modifiers": [ [ "species_10481286", "catalyst" ] ], "additional_components": [ "FBgn0037341" ] }, "reaction_10454110": { "compartment": "compartment_876", "id": "reaction_10454110", "reactome": "R-DME-749456", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445744", "species_10445742" ], "products": [ "species_10445746" ], "modifiers": [], "additional_components": [ "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10437323": { "compartment": "compartment_947587", "id": "reaction_10437323", "reactome": "R-DME-167433", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10434469" ], "products": [ "species_10437302" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10437321": { "compartment": "compartment_70101", "id": "reaction_10437321", "reactome": "R-DME-167429", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10437316" ], "products": [ "species_10434583" ], "modifiers": [ [ "species_10434215", "catalyst" ] ], "additional_components": [ "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054" ] }, "reaction_10437318": { "compartment": "compartment_70101", "id": "reaction_10437318", "reactome": "R-DME-167419", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437304" ], "products": [ "species_29420", "species_10437316" ], "modifiers": [], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P38040", "FBgn0004921", "P26308", "FBgn0001105" ] }, "reaction_10437300": { "compartment": "compartment_947587", "id": "reaction_10437300", "reactome": "R-DME-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10434217" ], "products": [ "species_29438", "species_10434469" ], "modifiers": [ [ "species_10434215", "catalyst" ] ], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054" ] }, "reaction_10498096": { "compartment": "compartment_70101", "id": "reaction_10498096", "reactome": "R-DME-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10438771", "catalyst" ] ], "additional_components": [ "FBgn0000479" ] }, "reaction_10434424": { "compartment": "compartment_70101", "id": "reaction_10434424", "reactome": "R-DME-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10434417", "catalyst" ] ], "additional_components": [ "FBgn0000479" ] }, "reaction_10438774": { "compartment": "compartment_70101", "id": "reaction_10438774", "reactome": "R-DME-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438768", "species_113592" ], "products": [ "species_10438771", "species_29370" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "FBgn0000479", "FBgn0000479", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10437758": { "compartment": "compartment_876", "id": "reaction_10437758", "reactome": "R-DME-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437751" ], "products": [ "species_29372", "species_10437755" ], "modifiers": [ [ "species_10437751", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "P20353", "FBgn0001104", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437771": { "compartment": "compartment_876", "id": "reaction_10437771", "reactome": "R-DME-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437769" ], "products": [ "species_10434384", "species_10437767", "species_10437753" ], "modifiers": [], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "species_29420", "P20353", "FBgn0001104", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420" ] }, "reaction_10437783": { "compartment": "compartment_876", "id": "reaction_10437783", "reactome": "R-DME-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437751" ], "products": [ "species_29372", "species_10437769" ], "modifiers": [ [ "species_10437751", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437760": { "compartment": "compartment_876", "id": "reaction_10437760", "reactome": "R-DME-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437749", "species_10437740" ], "products": [ "species_10437751" ], "modifiers": [], "additional_components": [ "P20353", "FBgn0001104", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10434222": { "compartment": "compartment_70101", "id": "reaction_10434222", "reactome": "R-DME-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10434219", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10434471": { "compartment": "compartment_70101", "id": "reaction_10434471", "reactome": "R-DME-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10434219" ], "products": [ "species_29372", "species_10434469", "species_10434186" ], "modifiers": [], "additional_components": [ "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P25455", "FBgn0004611", "P13217", "FBgn0262738" ] }, "reaction_10437774": { "compartment": "compartment_876", "id": "reaction_10437774", "reactome": "R-DME-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10437762", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437765": { "compartment": "compartment_876", "id": "reaction_10437765", "reactome": "R-DME-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434384", "species_10437740" ], "products": [ "species_10437762" ], "modifiers": [ [ "species_10434384", "catalyst" ] ], "additional_components": [ "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437781": { "compartment": "compartment_876", "id": "reaction_10437781", "reactome": "R-DME-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437762" ], "products": [ "species_10437776", "species_29372" ], "modifiers": [ [ "species_10437762", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437778": { "compartment": "compartment_876", "id": "reaction_10437778", "reactome": "R-DME-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437776" ], "products": [ "species_10434384", "species_10437753" ], "modifiers": [], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420" ] }, "reaction_10454108": { "compartment": "compartment_984", "id": "reaction_10454108", "reactome": "R-DME-749454", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445750" ], "products": [ "species_10434579", "species_10437747", "species_10445742" ], "modifiers": [], "additional_components": [ "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "P20353", "FBgn0001104", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P20353", "FBgn0001104", "species_29438", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10495699": { "compartment": "compartment_876", "id": "reaction_10495699", "reactome": "R-DME-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495697" ], "products": [ "species_10495695", "species_10437767" ], "modifiers": [], "additional_components": [ "species_29420", "P20353", "FBgn0001104", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "species_29420", "P20353", "FBgn0001104" ] }, "reaction_10495369": { "compartment": "compartment_876", "id": "reaction_10495369", "reactome": "R-DME-8964242", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10495361" ], "products": [ "species_29370", "species_10495366" ], "modifiers": [ [ "species_10495361", "catalyst" ] ], "additional_components": [ "P20353", "FBgn0001104", "species_29438", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "P20353", "FBgn0001104", "species_29438", "P20353", "FBgn0001104", "species_29438", "P00528", "FBgn0262733" ] }, "reaction_10495371": { "compartment": "compartment_70101", "id": "reaction_10495371", "reactome": "R-DME-8964329", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495366" ], "products": [ "species_10437747", "species_10495364" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "P20353", "FBgn0001104", "species_29438", "P20353", "FBgn0001104", "species_29438", "FBgn0262733" ] }, "reaction_10495707": { "compartment": "compartment_876", "id": "reaction_10495707", "reactome": "R-DME-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495695", "species_10437747" ], "products": [ "species_10495705" ], "modifiers": [], "additional_components": [ "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "P20353", "FBgn0001104", "species_29438", "P20353", "FBgn0001104", "species_29438", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927" ] }, "reaction_10454114": { "compartment": "compartment_876", "id": "reaction_10454114", "reactome": "R-DME-751001", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10437767" ], "products": [ "species_10445744" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P20353", "FBgn0001104", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10495710": { "compartment": "compartment_876", "id": "reaction_10495710", "reactome": "R-DME-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495705" ], "products": [ "species_29372", "species_10495697" ], "modifiers": [ [ "species_10495705", "catalyst" ] ], "additional_components": [ "P20353", "FBgn0001104", "species_29438", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "species_29420", "P20353", "FBgn0001104", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "P20353", "FBgn0001104", "species_29438", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927" ] }, "reaction_10445760": { "compartment": "compartment_947587", "id": "reaction_10445760", "reactome": "R-DME-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10445746" ], "products": [ "species_29420", "species_10445750" ], "modifiers": [ [ "species_10445746", "catalyst" ], [ "species_10445756", "inhibitor" ] ], "additional_components": [ "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "P20353", "FBgn0001104", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "FBgn0040080" ] }, "reaction_10454106": { "compartment": "compartment_70101", "id": "reaction_10454106", "reactome": "R-DME-749453", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10454097" ], "products": [ "species_29420", "species_10454103" ], "modifiers": [ [ "species_10454097", "catalyst" ] ], "additional_components": [ "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10447293": { "compartment": "compartment_876", "id": "reaction_10447293", "reactome": "R-DME-416516", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434217", "species_10434429" ], "products": [ "species_10447291" ], "modifiers": [], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "FBgn0260798", "P32865", "FBgn0260798", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10495715": { "compartment": "compartment_876", "id": "reaction_10495715", "reactome": "R-DME-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495701" ], "products": [ "species_29372", "species_10495712" ], "modifiers": [ [ "species_10495701", "catalyst" ] ], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q8T017", "FBgn0028743", "Q8T017", "FBgn0028743", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q8T017", "FBgn0028743" ] }, "reaction_10447579": { "compartment": "compartment_876", "id": "reaction_10447579", "reactome": "R-DME-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434217" ], "products": [ "species_10434979" ], "modifiers": [ [ "species_10434217", "catalyst" ], [ "species_10447577", "catalyst" ] ], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "FBgn0028743" ] }, "reaction_10495717": { "compartment": "compartment_876", "id": "reaction_10495717", "reactome": "R-DME-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495712" ], "products": [ "species_10434979", "species_10447577" ], "modifiers": [], "additional_components": [ "Q8T017", "FBgn0028743", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "FBgn0028743" ] }, "reaction_10445588": { "compartment": "compartment_70101", "id": "reaction_10445588", "reactome": "R-DME-379048", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10445581" ], "products": [ "species_29420", "species_10445583" ], "modifiers": [ [ "species_10445585", "catalyst" ] ], "additional_components": [ "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9NBC8", "FBgn0039595", "species_266013" ] }, "reaction_10447284": { "compartment": "compartment_70101", "id": "reaction_10447284", "reactome": "R-DME-400586", "name": "G alpha (q) binds to Trio family RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447280", "species_10434217" ], "products": [ "species_10447282" ], "modifiers": [], "additional_components": [ "FBgn0024277", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q7KVD1", "FBgn0024277" ] }, "reaction_10453966": { "compartment": "compartment_876", "id": "reaction_10453966", "reactome": "R-DME-749448", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434981", "species_10445579" ], "products": [ "species_10445581" ], "modifiers": [], "additional_components": [ "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10454089": { "compartment": "compartment_984", "id": "reaction_10454089", "reactome": "R-DME-749452", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445583" ], "products": [ "species_10454081", "species_10434579", "species_10454087", "species_10434217" ], "modifiers": [], "additional_components": [ "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VFW6", "FBgn0038139", "Q9VFW5", "FBgn0038140", "Q8ITC9", "FBgn0038201", "Q8ITC7", "FBgn0037100", "Q9NBC8", "FBgn0039595", "Q9VML9", "FBgn0085410", "O01668", "FBgn0019940", "Q8IN35", "FBgn0038880", "Q7KTL9", "FBgn0025595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "P16395", "FBgn0000037", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q4V622", "FBgn0033058", "A1ZAX0", "FBgn0050106", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_74016", "species_29370", "species_419777", "species_113592", "species_210382", "species_163953", "species_1562550", "species_114523", "species_2161759", "P14599", "FBgn0000108", "CHEBI:28716", "species_3632881", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_9024011", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "species_29444", "species_29468", "species_113585", "species_417891", "CHEBI:28918", "species_351597", "species_205687", "CHEBI:52450", "species_29460", "CHEBI:31011", "CHEBI:30772", "species_29416", "CHEBI:30768", "CHEBI:50122", "species_33549", "CHEBI:42504", "species_372533", "species_266074", "species_266013", "species_266033", "species_416436", "CHEBI:17120", "species_209849", "species_390899", "CHEBI:15627", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_879535", "species_265287", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10495703": { "compartment": "compartment_876", "id": "reaction_10495703", "reactome": "R-DME-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447577", "species_10434217" ], "products": [ "species_10495701" ], "modifiers": [], "additional_components": [ "FBgn0028743", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q8T017", "FBgn0028743" ] }, "reaction_10465276": { "compartment": "compartment_70101", "id": "reaction_10465276", "reactome": "R-DME-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10465273", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "P04412", "FBgn0003731", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10465281": { "compartment": "compartment_876", "id": "reaction_10465281", "reactome": "R-DME-2179413", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465278" ], "products": [ "species_10459256" ], "modifiers": [ [ "species_10447182", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "species_114519", "P05130", "FBgn0003091" ] }, "reaction_10447184": { "compartment": "compartment_876", "id": "reaction_10447184", "reactome": "R-DME-400015", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434436", "species_114519" ], "products": [ "species_10447182" ], "modifiers": [], "additional_components": [ "FBgn0003091", "species_114519", "P05130", "FBgn0003091" ] }, "reaction_10454112": { "compartment": "compartment_876", "id": "reaction_10454112", "reactome": "R-DME-750993", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10434979" ], "products": [ "species_10434981" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10435008": { "compartment": "compartment_876", "id": "reaction_10435008", "reactome": "R-DME-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435003" ], "products": [ "species_10435005" ], "modifiers": [ [ "species_10434219", "catalyst" ] ], "additional_components": [ "species_179856", "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "species_114519", "species_114520", "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10498738": { "compartment": "compartment_70101", "id": "reaction_10498738", "reactome": "R-DME-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10434417", "catalyst" ] ], "additional_components": [ "FBgn0000479" ] }, "reaction_10445545": { "compartment": "compartment_70101", "id": "reaction_10445545", "reactome": "R-DME-379044", "name": "Liganded Gs-activating GPCR acts as a GEF for Gs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445536", "species_29438" ], "products": [ "species_29420", "species_10445542" ], "modifiers": [ [ "species_10445536", "catalyst" ] ], "additional_components": [ "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "species_391200", "Q9W3V5", "FBgn0029909", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "species_380873", "Q4LBB9", "FBgn0038063", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain", "Q9NBC8", "FBgn0039595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q7KTL9", "FBgn0025595", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582", "species_83908", "Q9VAA2", "FBgn0039747", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "species_391200", "Q9W3V5", "FBgn0029909", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "species_380873", "Q4LBB9", "FBgn0038063", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain", "Q9NBC8", "FBgn0039595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q7KTL9", "FBgn0025595", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29438", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "species_391200", "Q9W3V5", "FBgn0029909", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "species_380873", "Q4LBB9", "FBgn0038063", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain", "Q9NBC8", "FBgn0039595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q7KTL9", "FBgn0025595", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582" ] }, "reaction_10447560": { "compartment": "compartment_70101", "id": "reaction_10447560", "reactome": "R-DME-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10447557", "catalyst" ] ], "additional_components": [ "B7YZV4", "FBgn0264815", "Q9VFI9", "FBgn0038237", "Q9VJ79", "FBgn0085370", "Q6NNF2", "FBgn0266377", "Q9W4T4", "FBgn0000479" ] }, "reaction_10446862": { "compartment": "compartment_876", "id": "reaction_10446862", "reactome": "R-DME-398185", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444613", "species_10446856" ], "products": [ "species_10446860" ], "modifiers": [], "additional_components": [ "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "P25157", "FBgn0000384", "species_29438", "A1ZAN6", "FBgn0023172", "P25157", "FBgn0000384", "species_29438", "A1ZAN6", "FBgn0023172", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740" ] }, "reaction_10434925": { "compartment": "compartment_70101", "id": "reaction_10434925", "reactome": "R-DME-114548", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434913", "species_10434918" ], "products": [ "species_10434920" ], "modifiers": [], "additional_components": [ "P25157", "FBgn0000384", "species_29438", "FBgn0023172", "A1ZAN6", "FBgn0023172", "P25157", "FBgn0000384", "species_29438" ] }, "reaction_10447565": { "compartment": "compartment_876", "id": "reaction_10447565", "reactome": "R-DME-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446850" ], "products": [ "species_10447562" ], "modifiers": [ [ "species_10446850", "catalyst" ] ], "additional_components": [ "P25157", "FBgn0000384", "species_29438", "P25157", "FBgn0000384", "species_29420", "P25157", "FBgn0000384", "species_29438" ] }, "reaction_10454125": { "compartment": "compartment_876", "id": "reaction_10454125", "reactome": "R-DME-751039", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10447562" ], "products": [ "species_10434939" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P25157", "FBgn0000384", "species_29420", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10454123": { "compartment": "compartment_70101", "id": "reaction_10454123", "reactome": "R-DME-751029", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10454120" ], "products": [ "species_29420", "species_10454118" ], "modifiers": [ [ "species_10454120", "catalyst" ] ], "additional_components": [ "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P25157", "FBgn0000384", "species_29438", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10434923": { "compartment": "compartment_70101", "id": "reaction_10434923", "reactome": "R-DME-114544", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10434920", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "A1ZAN6", "FBgn0023172", "P25157", "FBgn0000384", "species_29438" ] }, "reaction_10446858": { "compartment": "compartment_70101", "id": "reaction_10446858", "reactome": "R-DME-398184", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442529", "species_10446850" ], "products": [ "species_10446856" ], "modifiers": [], "additional_components": [ "FBgn0023172", "P25157", "FBgn0000384", "species_29438", "P25157", "FBgn0000384", "species_29438", "A1ZAN6", "FBgn0023172" ] }, "reaction_10447654": { "compartment": "compartment_70101", "id": "reaction_10447654", "reactome": "R-DME-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447308" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10442560", "catalyst" ] ], "additional_components": [ "species_29420", "P48148", "Rho1", "P48148", "Rho1", "species_29438", "A1ZAN6", "FBgn0023172", "A1ZBA1", "FBgn0050115", "Q9W0S2", "FBgn0264707", "Q8IQ97", "FBgn0003041", "A8DZ19", "FBgn0015803", "Q9VVC6", "FBgn0261547", "Q7K4E0", "FBgn0050440", "P26675", "Sos", "P91621", "FBgn0085447", "M9PBE1", "FBgn0032796", "M9ND00", "FBgn0023388", "X2JC00", "FBgn0025836", "P25157", "FBgn0000384", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VW85", "FBgn0261556" ] }, "reaction_10497274": { "compartment": "compartment_70101", "id": "reaction_10497274", "reactome": "R-DME-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10441880", "species_10446639" ], "products": [ "species_10497272" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10495392": { "compartment": "compartment_876", "id": "reaction_10495392", "reactome": "R-DME-8964634", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495375", "species_10439137" ], "products": [ "species_10495381" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "FBgn0010341", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495379": { "compartment": "compartment_876", "id": "reaction_10495379", "reactome": "R-DME-8964599", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495377" ], "products": [ "species_10434579", "species_10439139", "species_10442520", "species_10446511" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29438", "P40793", "FBgn0010341", "FBgn0015803", "FBgn0267698" ] }, "reaction_10495384": { "compartment": "compartment_876", "id": "reaction_10495384", "reactome": "R-DME-8964604", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495381" ], "products": [ "species_10495377" ], "modifiers": [ [ "species_10495381", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495386": { "compartment": "compartment_70101", "id": "reaction_10495386", "reactome": "R-DME-8964605", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495373", "species_10434579" ], "products": [ "species_10495375" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495388": { "compartment": "compartment_876", "id": "reaction_10495388", "reactome": "R-DME-8964614", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495377" ], "products": [ "species_10495377" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495390": { "compartment": "compartment_70101", "id": "reaction_10495390", "reactome": "R-DME-8964619", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442520", "species_10446511" ], "products": [ "species_10495373" ], "modifiers": [], "additional_components": [ "FBgn0015803", "FBgn0267698", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10446527": { "compartment": "compartment_70101", "id": "reaction_10446527", "reactome": "R-DME-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446523", "species_10446509" ], "products": [ "species_10446525", "species_10446511" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698" ] }, "reaction_10478015": { "compartment": "compartment_7660", "id": "reaction_10478015", "reactome": "R-DME-5692749", "name": "CDC14A,B bind MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478007", "species_10478009" ], "products": [ "species_10478013" ], "modifiers": [], "additional_components": [ "FBgn0003256", "FBgn0031952", "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256" ] }, "reaction_10476696": { "compartment": "compartment_7660", "id": "reaction_10476696", "reactome": "R-DME-5687097", "name": "p-S857 NCOA3 binds ETV4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476692", "species_10476677" ], "products": [ "species_10476694" ], "modifiers": [], "additional_components": [ "FBgn0039225", "FBgn0041092", "M9ND53", "FBgn0041092", "Q8MRW5", "FBgn0039225" ] }, "reaction_10476719": { "compartment": "compartment_70101", "id": "reaction_10476719", "reactome": "R-DME-5687126", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476700" ], "products": [ "species_10476687" ], "modifiers": [], "additional_components": [] }, "reaction_10476715": { "compartment": "compartment_70101", "id": "reaction_10476715", "reactome": "R-DME-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476662" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0003256", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10478027": { "compartment": "compartment_7660", "id": "reaction_10478027", "reactome": "R-DME-5692764", "name": "MAPK6 binds CCND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476706", "species_10457981" ], "products": [ "species_10478025" ], "modifiers": [ [ "species_10478009", "catalyst" ] ], "additional_components": [ "FBgn0003256", "FBgn0010315", "Q7KUZ5", "FBgn0010315", "P40417", "FBgn0003256", "FBgn0031952" ] }, "reaction_10476682": { "compartment": "compartment_7660", "id": "reaction_10476682", "reactome": "R-DME-5687090", "name": "p-S MAPK6 phosphorylates NCOA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10476674" ], "products": [ "species_113582", "species_10476677" ], "modifiers": [ [ "species_10476679", "catalyst" ] ], "additional_components": [ "FBgn0041092", "FBgn0041092", "FBgn0003256" ] }, "reaction_10476712": { "compartment": "compartment_7660", "id": "reaction_10476712", "reactome": "R-DME-5687109", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476708" ], "products": [ "species_10476702" ], "modifiers": [ [ "species_10437629", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "FBgn0020497" ] }, "reaction_10478023": { "compartment": "compartment_7660", "id": "reaction_10478023", "reactome": "R-DME-5692755", "name": "CDK1 phosphorylates MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10476706" ], "products": [ "species_113582", "species_10478007" ], "modifiers": [ [ "species_10437599", "catalyst" ] ], "additional_components": [ "FBgn0003256", "FBgn0003256", "FBgn0004106" ] }, "reaction_10476710": { "compartment": "compartment_70101", "id": "reaction_10476710", "reactome": "R-DME-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476702" ], "products": [ "species_10476708" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10478020": { "compartment": "compartment_7660", "id": "reaction_10478020", "reactome": "R-DME-5692754", "name": "CDC14A,B dephosphorylate p-3S,T MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10478013" ], "products": [ "species_113550", "species_10478017" ], "modifiers": [ [ "species_10478013", "catalyst" ] ], "additional_components": [ "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256", "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256", "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256" ] }, "reaction_10476672": { "compartment": "compartment_70101", "id": "reaction_10476672", "reactome": "R-DME-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10476664" ], "products": [ "species_29370", "species_10476667" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "FBgn0003256", "FBgn0003256", "FBgn0267698" ] }, "reaction_10498144": { "compartment": "compartment_12045", "id": "reaction_10498144", "reactome": "R-DME-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498135", "species_71284" ], "products": [ "species_10498140", "species_71285" ], "modifiers": [ [ "species_10480013", "catalyst" ], [ "species_10498142", "inhibitor" ] ], "additional_components": [ "Q9VU37", "FBgn0036336", "species_1562550", "Q9VU37", "FBgn0036336", "species_1562550" ] }, "reaction_10498305": { "compartment": "compartment_17906", "id": "reaction_10498305", "reactome": "R-DME-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498284" ], "products": [ "species_10498303" ], "modifiers": [], "additional_components": [] }, "reaction_10498183": { "compartment": "compartment_876", "id": "reaction_10498183", "reactome": "R-DME-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10498179" ], "products": [ "species_10498181" ], "modifiers": [], "additional_components": [ "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096", "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096" ] }, "reaction_10498311": { "compartment": "compartment_876", "id": "reaction_10498311", "reactome": "R-DME-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469704" ], "products": [ "species_10498309" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10498186": { "compartment": "compartment_876", "id": "reaction_10498186", "reactome": "R-DME-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437905", "species_29356" ], "products": [ "species_10437907", "species_8848337" ], "modifiers": [ [ "species_10498179", "catalyst" ], [ "species_10498181", "inhibitor" ] ], "additional_components": [ "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096", "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096" ] }, "reaction_10498157": { "compartment": "compartment_70101", "id": "reaction_10498157", "reactome": "R-DME-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498147", "species_2530486" ], "products": [ "species_111294", "species_10498151" ], "modifiers": [ [ "species_10466175", "catalyst" ], [ "species_10498155", "inhibitor" ] ], "additional_components": [ "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424", "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424" ] }, "reaction_10498317": { "compartment": "compartment_70101", "id": "reaction_10498317", "reactome": "R-DME-9654523", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471169", "species_10498313" ], "products": [ "species_10498315" ], "modifiers": [], "additional_components": [ "Q06849", "FBgn0004908", "species_29438", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "Q06849", "FBgn0004908", "species_29438" ] }, "reaction_10498192": { "compartment": "compartment_12045", "id": "reaction_10498192", "reactome": "R-DME-9647999", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498151" ], "products": [ "species_10498135" ], "modifiers": [ [ "species_10498189", "catalyst" ] ], "additional_components": [ "FBgn0029121" ] }, "reaction_10498321": { "compartment": "compartment_70101", "id": "reaction_10498321", "reactome": "R-DME-9654525", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473927", "species_10498309" ], "products": [ "species_10498313" ], "modifiers": [ [ "species_10498319", "inhibitor" ] ], "additional_components": [ "FBgn0032059", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "Q9VLJ0", "FBgn0032059" ] }, "reaction_10498194": { "compartment": "compartment_12045", "id": "reaction_10498194", "reactome": "R-DME-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498140" ], "products": [ "species_10437907" ], "modifiers": [], "additional_components": [] }, "reaction_10498196": { "compartment": "compartment_876", "id": "reaction_10498196", "reactome": "R-DME-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10437899" ], "products": [ "species_10438980" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29420" ] }, "reaction_10498324": { "compartment": "compartment_876", "id": "reaction_10498324", "reactome": "R-DME-9654533", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498315" ], "products": [ "species_10471169", "species_10434387", "species_10437907", "species_10473927" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "Q06849", "FBgn0004908", "species_29438", "Q06849", "FBgn0004908", "species_29438", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "FBgn0032059" ] }, "reaction_10498293": { "compartment": "compartment_70101", "id": "reaction_10498293", "reactome": "R-DME-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437907", "species_113592" ], "products": [ "species_10498284", "species_29370" ], "modifiers": [ [ "species_10498290", "catalyst" ] ], "additional_components": [ "Q9VL34", "FBgn0032187", "Q03043", "FBgn0000721", "Q03042", "FBgn0000442", "species_30991", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10498166": { "compartment": "compartment_876", "id": "reaction_10498166", "reactome": "R-DME-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498160" ], "products": [ "species_10437905" ], "modifiers": [], "additional_components": [] }, "reaction_10498168": { "compartment": "compartment_70101", "id": "reaction_10498168", "reactome": "R-DME-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9653479", "species_10466175" ], "products": [ "species_10498155" ], "modifiers": [], "additional_components": [ "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424", "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424" ] }, "reaction_10498298": { "compartment": "compartment_12045", "id": "reaction_10498298", "reactome": "R-DME-9653514", "name": "USP17L2 deubiquitinates RCE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498189", "species_29356" ], "products": [ "species_10498295", "species_10477101" ], "modifiers": [ [ "species_10479178", "catalyst" ] ], "additional_components": [ "FBgn0029121", "FBgn0029121", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0260936" ] }, "reaction_10498300": { "compartment": "compartment_876", "id": "reaction_10498300", "reactome": "R-DME-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10437907" ], "products": [ "species_10469704" ], "modifiers": [ [ "species_10498284", "inhibitor" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10498350": { "compartment": "compartment_876", "id": "reaction_10498350", "reactome": "R-DME-9658253", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10431820" ], "products": [ "species_10498348" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "species_29438", "P08646", "RAS85D" ] }, "reaction_10498362": { "compartment": "compartment_876", "id": "reaction_10498362", "reactome": "R-DME-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498358", "species_10437914" ], "products": [ "species_10498360" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29438", "FBgn0026376", "M9PCE9", "FBgn0026376", "P08646", "RAS85D", "species_29438" ] }, "reaction_10475845": { "compartment": "compartment_876", "id": "reaction_10475845", "reactome": "R-DME-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475842", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q5BIB8", "FBgn0087011", "Q4V4U2", "FBgn0050280", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "P00528", "FBgn0262733", "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VQM8", "FBgn0085422", "Q7KTU3", "FBgn0037188", "A1ZAU6", "FBgn0034230", "Q9XTN2", "chico", "Q9VLL4", "FBgn0032042", "Q9VMF3", "FBgn0265778" ] }, "reaction_10498201": { "compartment": "compartment_876", "id": "reaction_10498201", "reactome": "R-DME-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909" ], "products": [ "species_10438980" ], "modifiers": [ [ "species_10437909", "catalyst" ] ], "additional_components": [ "species_29438", "P08646", "RAS85D", "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D" ] }, "reaction_10476045": { "compartment": "compartment_876", "id": "reaction_10476045", "reactome": "R-DME-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475910", "species_10475915" ], "products": [ "species_10475917" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0037432", "Q9VI08", "FBgn0037432", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10490146": { "compartment": "compartment_70101", "id": "reaction_10490146", "reactome": "R-DME-8868118", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10490103" ], "products": [ "species_10490143", "species_29370" ], "modifiers": [ [ "species_10490103", "catalyst" ] ], "additional_components": [ "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985" ] }, "reaction_10476043": { "compartment": "compartment_70101", "id": "reaction_10476043", "reactome": "R-DME-5675376", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10475991" ], "products": [ "species_29372", "species_10476027" ], "modifiers": [ [ "species_10476040", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q9VVW5", "FBgn0036844" ] }, "reaction_10475978": { "compartment": "compartment_20699", "id": "reaction_10475978", "reactome": "R-DME-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475782", "species_10475974" ], "products": [ "species_10475976" ], "modifiers": [], "additional_components": [ "FBgn0038256", "Q9VFG7", "FBgn0038256", "P11346", "Raf" ] }, "reaction_10476055": { "compartment": "compartment_876", "id": "reaction_10476055", "reactome": "R-DME-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476049", "species_29356" ], "products": [ "species_29372", "species_10476053" ], "modifiers": [ [ "species_10440527", "catalyst" ], [ "species_10476009", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P29310", "14-3-3zeta", "P11346", "Raf", "species_29438", "P08646", "RAS85D" ] }, "reaction_10490105": { "compartment": "compartment_70101", "id": "reaction_10490105", "reactome": "R-DME-8867654", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490101", "species_10450702" ], "products": [ "species_10490103" ], "modifiers": [], "additional_components": [ "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985" ] }, "reaction_10490108": { "compartment": "compartment_70101", "id": "reaction_10490108", "reactome": "R-DME-8867658", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490103" ], "products": [ "species_29372", "species_10490101", "species_10451567" ], "modifiers": [ [ "species_10490103", "catalyst" ] ], "additional_components": [ "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985", "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985" ] }, "reaction_10476011": { "compartment": "compartment_876", "id": "reaction_10476011", "reactome": "R-DME-5675194", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475854" ], "products": [ "species_29370", "species_10476009" ], "modifiers": [ [ "species_10475991", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256" ] }, "reaction_10476019": { "compartment": "compartment_876", "id": "reaction_10476019", "reactome": "R-DME-5675198", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475856", "species_113592" ], "products": [ "species_10476017", "species_29370" ], "modifiers": [ [ "species_10475991", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256" ] }, "reaction_10476002": { "compartment": "compartment_70101", "id": "reaction_10476002", "reactome": "R-DME-5674496", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475867" ], "products": [ "species_29370", "species_10475999" ], "modifiers": [ [ "species_10475991", "catalyst" ] ], "additional_components": [ "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256" ] }, "reaction_10497901": { "compartment": "compartment_70101", "id": "reaction_10497901", "reactome": "R-DME-9635739", "name": "PTPN7 dephosphorylates p-T,Y-MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497886", "species_29356" ], "products": [ "species_29372", "species_10497898" ], "modifiers": [ [ "species_10497886", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641", "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641", "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641" ] }, "reaction_10476064": { "compartment": "compartment_876", "id": "reaction_10476064", "reactome": "R-DME-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10475910" ], "products": [ "species_10476049", "species_29372" ], "modifiers": [ [ "species_10476061", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0005777" ] }, "reaction_10497903": { "compartment": "compartment_70101", "id": "reaction_10497903", "reactome": "R-DME-9635743", "name": "PTPN7 binds p-T,Y-MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497884", "species_10458636" ], "products": [ "species_10497886" ], "modifiers": [], "additional_components": [ "FBgn0016641", "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641" ] }, "reaction_10498198": { "compartment": "compartment_876", "id": "reaction_10498198", "reactome": "R-DME-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475919": { "compartment": "compartment_876", "id": "reaction_10475919", "reactome": "R-DME-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475906", "species_10475862", "species_10475896", "species_10433742" ], "products": [ "species_10475908" ], "modifiers": [ [ "species_10475917", "inhibitor" ] ], "additional_components": [ "Q24324", "phospho-Dsor1", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0003256", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "Q9VI08", "FBgn0037432", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475967": { "compartment": "compartment_74700", "id": "reaction_10475967", "reactome": "R-DME-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475963" ], "products": [ "species_29370", "species_10475965" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "Q24324", "phospho-Dsor1" ] }, "reaction_10498338": { "compartment": "compartment_876", "id": "reaction_10498338", "reactome": "R-DME-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10475908" ], "products": [ "species_10475929" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10475933": { "compartment": "compartment_876", "id": "reaction_10475933", "reactome": "R-DME-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475922", "species_113592" ], "products": [ "species_10475924", "species_29370" ], "modifiers": [ [ "species_10475922", "catalyst" ], [ "species_10475931", "inhibitor" ], [ "species_10475927", "inhibitor" ], [ "species_10475929", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10498340": { "compartment": "compartment_876", "id": "reaction_10498340", "reactome": "R-DME-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475922", "species_9657570" ], "products": [ "species_10475931" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10498342": { "compartment": "compartment_876", "id": "reaction_10498342", "reactome": "R-DME-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475922", "species_9657574" ], "products": [ "species_10475927" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10475944": { "compartment": "compartment_876", "id": "reaction_10475944", "reactome": "R-DME-5672980", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475924" ], "products": [ "species_10475873", "species_10475910", "species_10475896", "species_10433771" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0003256" ] }, "reaction_10475941": { "compartment": "compartment_876", "id": "reaction_10475941", "reactome": "R-DME-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475908", "species_113592" ], "products": [ "species_10475922", "species_29370" ], "modifiers": [ [ "species_10475908", "catalyst" ], [ "species_10475939", "inhibitor" ], [ "species_10475929", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10498346": { "compartment": "compartment_876", "id": "reaction_10498346", "reactome": "R-DME-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475924", "species_9657577" ], "products": [ "species_10498344" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10475987": { "compartment": "compartment_20699", "id": "reaction_10475987", "reactome": "R-DME-5674373", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475982" ], "products": [ "species_10475984", "species_29370" ], "modifiers": [ [ "species_10475982", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10475969": { "compartment": "compartment_74700", "id": "reaction_10475969", "reactome": "R-DME-5674132", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475906", "species_10475959", "species_10475961", "species_10433742" ], "products": [ "species_10475963" ], "modifiers": [], "additional_components": [ "Q24324", "phospho-Dsor1", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "P11346", "Raf", "FBgn0003256", "P40417", "FBgn0003256", "P11346", "Raf", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "Q24324", "phospho-Dsor1" ] }, "reaction_10475995": { "compartment": "compartment_7660", "id": "reaction_10475995", "reactome": "R-DME-5674387", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475991" ], "products": [ "species_10475993" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10475803": { "compartment": "compartment_70101", "id": "reaction_10475803", "reactome": "R-DME-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10475790" ], "products": [ "species_29372", "species_10475798" ], "modifiers": [ [ "species_10440527", "catalyst" ] ], "additional_components": [ "P29310", "14-3-3zeta", "P11346", "Raf", "P11346", "Raf", "P29310", "14-3-3zeta" ] }, "reaction_10475851": { "compartment": "compartment_876", "id": "reaction_10475851", "reactome": "R-DME-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475771", "species_10475742" ], "products": [ "species_10475847" ], "modifiers": [ [ "species_10475849", "catalyst" ] ], "additional_components": [ "P29310", "14-3-3zeta", "P11346", "Raf", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0030018" ] }, "reaction_10475800": { "compartment": "compartment_70101", "id": "reaction_10475800", "reactome": "R-DME-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475798" ], "products": [ "species_10432010", "species_10475742" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "P29310", "14-3-3zeta" ] }, "reaction_10475878": { "compartment": "compartment_876", "id": "reaction_10475878", "reactome": "R-DME-5672969", "name": "Phosphorylation of RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475847" ], "products": [ "species_29370", "species_10475862" ], "modifiers": [ [ "species_10475875", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10498281": { "compartment": "compartment_876", "id": "reaction_10498281", "reactome": "R-DME-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657579", "species_10475847" ], "products": [ "species_10475939" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475778": { "compartment": "compartment_876", "id": "reaction_10475778", "reactome": "R-DME-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10475769" ], "products": [ "species_10475771" ], "modifiers": [ [ "species_10475776", "catalyst" ] ], "additional_components": [ "species_29438", "P08646", "RAS85D", "P29310", "14-3-3zeta", "P11346", "Raf", "P29310", "14-3-3zeta", "P11346", "Raf", "species_29438", "P08646", "RAS85D", "FBgn0002031" ] }, "reaction_10475792": { "compartment": "compartment_70101", "id": "reaction_10475792", "reactome": "R-DME-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475782", "species_10432010" ], "products": [ "species_10475790" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "P11346", "Raf" ] }, "reaction_10433759": { "compartment": "compartment_70101", "id": "reaction_10433759", "reactome": "R-DME-109857", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433755", "species_10433740" ], "products": [ "species_10433757" ], "modifiers": [], "additional_components": [ "FBgn0003256", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10434596": { "compartment": "compartment_70101", "id": "reaction_10434596", "reactome": "R-DME-112342", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10434587" ], "products": [ "species_10433778", "species_29370" ], "modifiers": [ [ "species_10434593", "catalyst" ] ], "additional_components": [ "Q24324", "phospho-Dsor1", "FBgn0004106" ] }, "reaction_10433794": { "compartment": "compartment_70101", "id": "reaction_10433794", "reactome": "R-DME-109863", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433773" ], "products": [ "species_10433755", "species_10433771" ], "modifiers": [], "additional_components": [ "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "FBgn0003256" ] }, "reaction_10498724": { "compartment": "compartment_263163", "id": "reaction_10498724", "reactome": "R-DME-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498720", "species_10498704" ], "products": [ "species_10498722" ], "modifiers": [], "additional_components": [ "Q9VIW6", "FBgn0032782", "P54733", "FBgn0010382", "Q9V3C1", "FBgn0041174", "Q8IP45", "FBgn0261268", "Q9VCI3", "FBgn0039114", "Q9VXY7", "FBgn0030608", "Q960X8", "FBgn0031450", "P20905", "FBgn0004573", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "Q9VIW6", "FBgn0032782", "P54733", "FBgn0010382", "Q9V3C1", "FBgn0041174", "Q8IP45", "FBgn0261268", "Q9VCI3", "FBgn0039114", "Q9VXY7", "FBgn0030608", "Q960X8", "FBgn0031450", "P20905", "FBgn0004573", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011" ] }, "reaction_10498726": { "compartment": "compartment_263163", "id": "reaction_10498726", "reactome": "R-DME-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498702", "species_113592" ], "products": [ "species_10498704" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011" ] }, "reaction_10498731": { "compartment": "compartment_263163", "id": "reaction_10498731", "reactome": "R-DME-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10498704" ], "products": [ "species_29372", "species_10498728" ], "modifiers": [ [ "species_10498704", "catalyst" ] ], "additional_components": [ "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29370", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011" ] }, "reaction_10496801": { "compartment": "compartment_70101", "id": "reaction_10496801", "reactome": "R-DME-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496796" ], "products": [ "species_10496798", "species_29372" ], "modifiers": [ [ "species_10496796", "catalyst" ] ], "additional_components": [ "Q8IMX7", "Miro", "species_29438", "Q8IMX7", "Miro", "species_29420", "Q8IMX7", "Miro", "species_29438" ] }, "reaction_10496812": { "compartment": "compartment_17906", "id": "reaction_10496812", "reactome": "R-DME-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496796", "species_10496806" ], "products": [ "species_10496810" ], "modifiers": [], "additional_components": [ "Q8IMX7", "Miro", "species_29438", "FBgn0262872", "Q960V3", "FBgn0262872", "Q8IMX7", "Miro", "species_29438" ] }, "reaction_10458700": { "compartment": "compartment_876", "id": "reaction_10458700", "reactome": "R-DME-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10458697", "catalyst" ] ], "additional_components": [ "B7YZX2", "FBgn0032706" ] }, "reaction_10472658": { "compartment": "compartment_70101", "id": "reaction_10472658", "reactome": "R-DME-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10472655", "catalyst" ] ], "additional_components": [ "Q9VHE0", "FBgn0037690", "Q9VFS9", "FBgn0038165" ] }, "reaction_10472583": { "compartment": "compartment_70101", "id": "reaction_10472583", "reactome": "R-DME-5577213", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10472580", "catalyst" ] ], "additional_components": [ "Q9VRE6", "FBgn0064123", "Q24270", "FBgn0001991", "M9PD84", "FBgn0259822", "X2J9Z3", "FBgn0028863", "Q8IP22", "FBgn0261999" ] }, "reaction_10472614": { "compartment": "compartment_876", "id": "reaction_10472614", "reactome": "R-DME-5577234", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10472611", "catalyst" ] ], "additional_components": [ "P17971", "FBgn0005564", "Q9VBL2", "FBgn0039380", "Q8IR92", "FBgn0265595" ] }, "reaction_10472943": { "compartment": "compartment_876", "id": "reaction_10472943", "reactome": "R-DME-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472941" ], "products": [ "species_10472926" ], "modifiers": [], "additional_components": [ "FBgn0003416", "FBgn0003416" ] }, "reaction_10466943": { "compartment": "compartment_70101", "id": "reaction_10466943", "reactome": "R-DME-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466879" ], "products": [ "species_10466941" ], "modifiers": [], "additional_components": [ "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_74016", "Q24214", "FBgn0015614", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_1222611", "species_1562550" ] }, "reaction_10466882": { "compartment": "compartment_70101", "id": "reaction_10466882", "reactome": "R-DME-2730849", "name": "Calcineurin binds and dephosphorylates NFAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10464038", "species_10464071" ], "products": [ "species_29372", "species_10466879" ], "modifiers": [ [ "species_10464071", "catalyst" ] ], "additional_components": [ "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614" ] }, "reaction_10472924": { "compartment": "compartment_876", "id": "reaction_10472924", "reactome": "R-DME-5607734", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470925", "species_112275" ], "products": [ "species_10472922" ], "modifiers": [], "additional_components": [ "FBgn0259680", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10472939": { "compartment": "compartment_876", "id": "reaction_10472939", "reactome": "R-DME-5607746", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472922" ], "products": [ "species_10472937" ], "modifiers": [], "additional_components": [ "species_112275", "P83099", "FBgn0259680", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10472929": { "compartment": "compartment_876", "id": "reaction_10472929", "reactome": "R-DME-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10472926", "catalyst" ] ], "additional_components": [ "FBgn0003416" ] }, "reaction_10489499": { "compartment": "compartment_876", "id": "reaction_10489499", "reactome": "R-DME-8858500", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489495", "species_10489479" ], "products": [ "species_10489497" ], "modifiers": [], "additional_components": [ "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "M9NE79", "FBgn0262357", "M9PB26", "FBgn0264341", "Q59DY5", "FBgn0053533", "Q59DY6", "FBgn0053532", "Q7JY62", "FBgn0040092", "Q8IRH8", "FBgn0035199", "Q9VIX1", "FBgn0016675", "Q9VKL8", "FBgn0040096", "Q9VLM0", "FBgn0040098", "Q9VM16", "FBgn0031910", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "M9NE79", "FBgn0262357", "M9PB26", "FBgn0264341", "Q59DY5", "FBgn0053533", "Q59DY6", "FBgn0053532", "Q7JY62", "FBgn0040092", "Q8IRH8", "FBgn0035199", "Q9VIX1", "FBgn0016675", "Q9VKL8", "FBgn0040096", "Q9VLM0", "FBgn0040098", "Q9VM16", "FBgn0031910", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004" ] }, "reaction_10473885": { "compartment": "compartment_876", "id": "reaction_10473885", "reactome": "R-DME-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10446844" ], "products": [ "species_10473881" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "P11346", "Raf", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475388": { "compartment": "compartment_7660", "id": "reaction_10475388", "reactome": "R-DME-5660666", "name": "CBP and p300 binds NF-kB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447242", "species_10473850" ], "products": [ "species_10475363" ], "modifiers": [], "additional_components": [ "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "M9MS40", "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10473883": { "compartment": "compartment_876", "id": "reaction_10473883", "reactome": "R-DME-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10473881" ], "products": [ "species_29370", "species_10473870" ], "modifiers": [ [ "species_10446511", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "species_29438", "P08646", "RAS85D", "FBgn0267698" ] }, "reaction_10475386": { "compartment": "compartment_7660", "id": "reaction_10475386", "reactome": "R-DME-5660660", "name": "p300 acetylates RELA subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475363", "species_113560" ], "products": [ "species_2485002", "species_10475383" ], "modifiers": [ [ "species_10475363", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "M9MS40", "FBgn0261617", "Q94527", "Rel", "P15330", "dl", "P98149", "Dif", "M9MS40", "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10473865": { "compartment": "compartment_7660", "id": "reaction_10473865", "reactome": "R-DME-5624473", "name": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437455" ], "products": [ "species_113582", "species_10473850" ], "modifiers": [ [ "species_10473862", "catalyst" ] ], "additional_components": [ "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "Q9V3I5", "FBgn0020412", "P12370", "Pka-C1", "P16911", "FBgn0000274", "Q9VA47", "FBgn0039796" ] }, "reaction_10473879": { "compartment": "compartment_876", "id": "reaction_10473879", "reactome": "R-DME-5624486", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10473870" ], "products": [ "species_10473876", "species_29370" ], "modifiers": [ [ "species_10444516", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "species_29438", "P08646", "RAS85D", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "FBgn0262733" ] }, "reaction_10475392": { "compartment": "compartment_7660", "id": "reaction_10475392", "reactome": "R-DME-5660980", "name": "p-S276-RELA binds RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472931", "species_10473848" ], "products": [ "species_10475390" ], "modifiers": [], "additional_components": [ "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl" ] }, "reaction_10486210": { "compartment": "compartment_7660", "id": "reaction_10486210", "reactome": "R-DME-6805755", "name": "EHMT1:EHMT2 dimethylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10467611" ], "products": [ "species_10486207", "species_77502" ], "modifiers": [ [ "species_10468978", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "M9PGH7", "FBgn0040372" ] }, "reaction_10467770": { "compartment": "compartment_7660", "id": "reaction_10467770", "reactome": "R-DME-3222237", "name": "SMYD2 methylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10427813" ], "products": [ "species_77502", "species_10467762" ], "modifiers": [ [ "species_10467767", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0011566" ] }, "reaction_10486202": { "compartment": "compartment_7660", "id": "reaction_10486202", "reactome": "R-DME-6805740", "name": "SETD8 methylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10427813" ], "products": [ "species_10467744", "species_77502" ], "modifiers": [ [ "species_10486199", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0011474" ] }, "reaction_10467748": { "compartment": "compartment_7660", "id": "reaction_10467748", "reactome": "R-DME-3222116", "name": "L3MBTL1 binds TP53 monomethylated on K382", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467744", "species_10467739" ], "products": [ "species_10467746" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0002441", "Q9VB52", "FBgn0002441", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10479851": { "compartment": "compartment_12045", "id": "reaction_10479851", "reactome": "R-DME-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6786220", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_6786225" ], "modifiers": [ [ "species_10479848", "catalyst" ] ], "additional_components": [ "FBgn0015032" ] }, "reaction_10440259": { "compartment": "compartment_70101", "id": "reaction_10440259", "reactome": "R-DME-193060", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_193079", "species_29364" ], "products": [ "species_29356", "species_193066", "species_29366", "species_29460" ], "modifiers": [ [ "species_10440256", "catalyst" ] ], "additional_components": [ "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395" ] }, "reaction_10428799": { "compartment": "compartment_70101", "id": "reaction_10428799", "reactome": "R-DME-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10428796", "catalyst" ] ], "additional_components": [ "Q95RV5", "FBgn0050499", "species_111793" ] }, "reaction_10428829": { "compartment": "compartment_70101", "id": "reaction_10428829", "reactome": "R-DME-71335", "name": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790", "species_29878" ], "products": [ "species_29578", "species_29512" ], "modifiers": [ [ "species_10428814", "catalyst" ] ], "additional_components": [ "Q9VHN7", "FBgn0037607", "species_29926", "species_8878387" ] }, "reaction_10428827": { "compartment": "compartment_70101", "id": "reaction_10428827", "reactome": "R-DME-71334", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29512", "species_29878" ], "modifiers": [ [ "species_10428824", "catalyst" ] ], "additional_components": [ "Q9W1G0", "FBgn0023477" ] }, "reaction_10495142": { "compartment": "compartment_70101", "id": "reaction_10495142", "reactome": "R-DME-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_73578", "species_29370" ], "modifiers": [ [ "species_10495139", "catalyst" ] ], "additional_components": [ "FBgn0025640" ] }, "reaction_10436633": { "compartment": "compartment_70101", "id": "reaction_10436633", "reactome": "R-DME-163741", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29882", "species_29578" ], "products": [ "species_29790", "species_73578" ], "modifiers": [ [ "species_10428814", "catalyst" ] ], "additional_components": [ "Q9VHN7", "FBgn0037607", "species_29926", "species_8878387" ] }, "reaction_10495719": { "compartment": "compartment_70101", "id": "reaction_10495719", "reactome": "R-DME-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10427848", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z7P1", "FBgn0033377" ] }, "reaction_10427926": { "compartment": "compartment_70101", "id": "reaction_10427926", "reactome": "R-DME-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29366" ], "products": [ "species_70106", "species_31467", "species_29364" ], "modifiers": [ [ "species_10427923", "catalyst" ] ], "additional_components": [ "P12646", "FBgn0004057", "species_29366" ] }, "reaction_10438837": { "compartment": "compartment_70101", "id": "reaction_10438837", "reactome": "R-DME-177784", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10428804", "catalyst" ] ], "additional_components": [ "FBgn0050410" ] }, "reaction_10434100": { "compartment": "compartment_70101", "id": "reaction_10434100", "reactome": "R-DME-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10430909", "catalyst" ], [ "species_29372", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VT33", "FBgn0036030" ] }, "reaction_10430912": { "compartment": "compartment_70101", "id": "reaction_10430912", "reactome": "R-DME-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_113592" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10430909", "catalyst" ] ], "additional_components": [ "Q9VT33", "FBgn0036030" ] }, "reaction_10479918": { "compartment": "compartment_70101", "id": "reaction_10479918", "reactome": "R-DME-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10427848", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z7P1", "FBgn0033377" ] }, "reaction_10428779": { "compartment": "compartment_70101", "id": "reaction_10428779", "reactome": "R-DME-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29996", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_29732" ], "modifiers": [ [ "species_10428776", "catalyst" ] ], "additional_components": [ "P41572", "FBgn0004654" ] }, "reaction_10479915": { "compartment": "compartment_70101", "id": "reaction_10479915", "reactome": "R-DME-6787321", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787328" ], "products": [ "species_29578", "species_29510" ], "modifiers": [ [ "species_10479912", "catalyst" ] ], "additional_components": [ "FBgn0033735" ] }, "reaction_10441190": { "compartment": "compartment_70101", "id": "reaction_10441190", "reactome": "R-DME-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10428796", "catalyst" ] ], "additional_components": [ "Q95RV5", "FBgn0050499", "species_111793" ] }, "reaction_10428769": { "compartment": "compartment_70101", "id": "reaction_10428769", "reactome": "R-DME-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10428766", "catalyst" ] ], "additional_components": [ "FBgn0030239" ] }, "reaction_214393": { "compartment": "compartment_70101", "id": "reaction_214393", "reactome": "R-DME-214393", "name": "Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Phosphorylated Relish (REL) is endoproteolytically cleaved by the caspase-8 orthologue, DREDD, between residues Asp545 and Gly546 at a consensus target site for group III caspases found in the interdomain linker. The two cleavage products, REL-68 and REL-49, dissociate from DREDD.", "reactants": [ "species_214409" ], "products": [ "species_205709", "species_354270", "species_214404" ], "modifiers": [ [ "species_205876", "catalyst" ] ], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4" ] }, "reaction_209167": { "compartment": "compartment_70101", "id": "reaction_209167", "reactome": "R-DME-209167", "name": "Phosphorylated REL is cleaved by and dissociates from DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Phosphorylated Relish (REL) is endoproteolytically cleaved by the caspase-8 orthologue, DREDD, between residues Asp545 and Gly546 at a consensus target site for group III caspases found in the interdomain linker. The two cleavage products, REL-68 and REL-49, dissociate from DREDD.", "reactants": [ "species_354322" ], "products": [ "species_205709", "species_354270", "species_354317" ], "modifiers": [ [ "species_205876", "catalyst" ] ], "additional_components": [ "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_10436024": { "compartment": "compartment_12045", "id": "reaction_10436024", "reactome": "R-DME-162721", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449299" ], "products": [ "species_29420", "species_162681" ], "modifiers": [ [ "species_10436021", "catalyst" ] ], "additional_components": [ "E1JIA5", "FBgn0259933", "Q9VIU7", "FBgn0032799", "Q2PDR0", "FBgn0053977" ] }, "reaction_10457726": { "compartment": "compartment_70101", "id": "reaction_10457726", "reactome": "R-DME-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718" ], "products": [ "species_10457724" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10457736": { "compartment": "compartment_70101", "id": "reaction_10457736", "reactome": "R-DME-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457724" ], "products": [ "species_10457734" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10466124": { "compartment": "compartment_70101", "id": "reaction_10466124", "reactome": "R-DME-2514867", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113" ], "products": [ "species_83910", "species_74016" ], "modifiers": [ [ "species_10431457", "catalyst" ] ], "additional_components": [ "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_30991" ] }, "reaction_10466121": { "compartment": "compartment_70101", "id": "reaction_10466121", "reactome": "R-DME-2514865", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431457" ], "products": [ "species_30991", "species_10431455" ], "modifiers": [], "additional_components": [ "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_30991", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145" ] }, "reaction_10467853": { "compartment": "compartment_70101", "id": "reaction_10467853", "reactome": "R-DME-3229181", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10431455" ], "products": [ "species_10467851" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10466231": { "compartment": "compartment_70101", "id": "reaction_10466231", "reactome": "R-DME-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466229", "species_74016" ], "products": [ "species_10431940" ], "modifiers": [], "additional_components": [ "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303" ] }, "reaction_10431958": { "compartment": "compartment_2514888", "id": "reaction_10431958", "reactome": "R-DME-74885", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438" ], "products": [ "species_111294", "species_30991" ], "modifiers": [ [ "species_10431905", "catalyst" ], [ "species_10431946", "catalyst" ], [ "species_10431952", "catalyst" ], [ "species_10431940", "inhibitor" ], [ "species_10431954", "inhibitor" ], [ "species_10431956", "inhibitor" ] ], "additional_components": [ "FBgn0085386", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303" ] }, "reaction_10431459": { "compartment": "compartment_70101", "id": "reaction_10431459", "reactome": "R-DME-74031", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_10431455" ], "products": [ "species_10431457" ], "modifiers": [], "additional_components": [ "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_30991" ] }, "reaction_10479843": { "compartment": "compartment_70101", "id": "reaction_10479843", "reactome": "R-DME-6786205", "name": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428994", "species_71284" ], "products": [ "species_71285", "species_10479835" ], "modifiers": [ [ "species_10479840", "catalyst" ] ], "additional_components": [ "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "Q9W2L0", "FBgn0034592", "P47947", "FBgn0013348", "Q9VMT2", "FBgn0031692", "A1Z777", "FBgn0050378", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "FBgn0032857" ] }, "reaction_10466178": { "compartment": "compartment_2514888", "id": "reaction_10466178", "reactome": "R-DME-2530501", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466165", "species_2530486" ], "products": [ "species_111294", "species_10466168" ], "modifiers": [ [ "species_10466175", "catalyst" ] ], "additional_components": [ "FBgn0004921", "FBgn0004921", "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424" ] }, "reaction_10443513": { "compartment": "compartment_984", "id": "reaction_10443513", "reactome": "R-DME-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171149", "species_194276" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10443510", "catalyst" ] ], "additional_components": [ "Q9I7L9", "FBgn0042175", "Q9Y168", "FBgn0051683" ] }, "reaction_10495519": { "compartment": "compartment_984", "id": "reaction_10495519", "reactome": "R-DME-8980228", "name": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10495516", "catalyst" ] ], "additional_components": [ "A1ZAL5", "FBgn0034166", "A8DYT7", "FBgn0085477", "M9MRT1", "FBgn0032289", "M9NFL7", "FBgn0036977", "P02843", "FBgn0004045", "P02844", "FBgn0005391", "P06607", "FBgn0004047", "Q0E8T1", "FBgn0250847", "Q4V566", "FBgn0085476", "Q7K3Z8", "FBgn0032029", "Q9VB88", "FBgn0039476", "Q9VB89", "FBgn0039475", "Q9VB90", "FBgn0039474", "Q9VB91", "FBgn0039473", "Q9VB92", "FBgn0039472", "Q9VB93", "FBgn0039471", "Q9VB94", "FBgn0039470", "Q9VBQ2", "FBgn0039344", "Q9VEY9", "FBgn0038398", "Q9VJH1", "FBgn0032612", "Q9VLU1", "FBgn0031976", "Q9VRW5", "FBgn0035697", "Q9VU78", "FBgn0036367", "Q9VX01", "FBgn0030884", "Q9VX69", "FBgn0030828", "Q9VX70", "FBgn0265267", "Q9VZN6", "FBgn0035453", "Q9W304", "FBgn0030162", "Q9W448", "FBgn0029831" ] }, "reaction_10459822": { "compartment": "compartment_70616", "id": "reaction_10459822", "reactome": "R-DME-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524101", "species_110577" ], "products": [ "species_159450", "species_1524064" ], "modifiers": [ [ "species_10459819", "catalyst" ] ], "additional_components": [ "FBgn0010350" ] }, "reaction_10474159": { "compartment": "compartment_18730", "id": "reaction_10474159", "reactome": "R-DME-5625416", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474075" ], "products": [ "species_10474157" ], "modifiers": [], "additional_components": [ "Q9VUY2", "FBgn0036567", "Q9VQA6", "FBgn0028570", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q7KMS3", "FBgn0024196", "Q0E8P6", "FBgn0023096", "Q9VLB9", "FBgn0032119", "species_29438", "species_29420", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "Q9VRK9", "FBgn0004380", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9W097", "FBgn0035264", "Q9VSJ6", "FBgn0265102", "Q7KRS6", "FBgn0016919", "Q9VFL0", "FBgn0038221", "Q9W040", "FBgn0035317", "Q9VII8", "FBgn0032891", "Q9VJ72", "FBgn0032692", "Q9VK41", "FBgn0032470", "Q9VQS5", "FBgn0031550", "Q9VF41", "FBgn0038358", "Q9VMC0", "FBgn0031829", "Q9VR64", "FBgn0031196", "A1Z6F0", "FBgn0050441", "A1Z6F0", "FBgn0050441", "Q9W040", "FBgn0035317", "Q9VK41", "FBgn0032470", "Q9VF41", "FBgn0038358", "Q9VR64", "FBgn0031196", "Q9VFL0", "FBgn0038221", "Q7KRS6", "FBgn0016919", "Q9VII8", "FBgn0032891", "Q9VQS5", "FBgn0031550", "Q9VMC0", "FBgn0031829", "Q9VJ72", "FBgn0032692", "Q9VLB9", "FBgn0032119", "Q24117", "FBgn0011760", "Q7KMS3", "FBgn0024196", "Q9VQA6", "FBgn0028570", "O96860", "FBgn0026141", "Q9VUY2", "FBgn0036567", "Q0E8P6", "FBgn0023096", "A1ZBM3", "FBgn0034452", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264", "Q9VZ07", "FBgn0028421", "Q9VRK9", "FBgn0004380", "P46867", "FBgn0004381", "species_29438", "species_29420" ] }, "reaction_10474169": { "compartment": "compartment_18730", "id": "reaction_10474169", "reactome": "R-DME-5625426", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474167" ], "products": [ "species_10474163" ], "modifiers": [], "additional_components": [ "A1Z6F0", "FBgn0050441", "Q9W040", "FBgn0035317", "Q9VK41", "FBgn0032470", "Q9VF41", "FBgn0038358", "Q9VR64", "FBgn0031196", "Q9VFL0", "FBgn0038221", "Q7KRS6", "FBgn0016919", "Q9VII8", "FBgn0032891", "Q9VQS5", "FBgn0031550", "Q9VMC0", "FBgn0031829", "Q9VJ72", "FBgn0032692", "Q9VZ07", "FBgn0028421", "Q9VRK9", "FBgn0004380", "P46867", "FBgn0004381", "Q9VLB9", "FBgn0032119", "Q24117", "FBgn0011760", "Q7KMS3", "FBgn0024196", "Q9VQA6", "FBgn0028570", "O96860", "FBgn0026141", "Q9VUY2", "FBgn0036567", "Q0E8P6", "FBgn0023096", "species_29438", "species_29420", "A1ZBM3", "FBgn0034452", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9W097", "FBgn0035264", "Q9VSJ6", "FBgn0265102", "Q7KRS6", "FBgn0016919", "Q9VFL0", "FBgn0038221", "Q9W040", "FBgn0035317", "Q9VII8", "FBgn0032891", "Q9VJ72", "FBgn0032692", "Q9VK41", "FBgn0032470", "Q9VQS5", "FBgn0031550", "Q9VF41", "FBgn0038358", "Q9VMC0", "FBgn0031829", "Q9VR64", "FBgn0031196", "A1Z6F0", "FBgn0050441", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "Q9VRK9", "FBgn0004380", "Q9VUY2", "FBgn0036567", "Q9VQA6", "FBgn0028570", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q7KMS3", "FBgn0024196", "Q0E8P6", "FBgn0023096", "Q9VLB9", "FBgn0032119", "species_29438", "species_29420" ] }, "reaction_10473319": { "compartment": "compartment_20699", "id": "reaction_10473319", "reactome": "R-DME-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473317" ], "products": [ "species_10473315", "species_10473310" ], "modifiers": [], "additional_components": [ "A1Z6F0", "FBgn0050441", "A0A4D6K5M0", "FBgn0027287", "FBgn0027287", "FBgn0050441" ] }, "reaction_10473908": { "compartment": "compartment_70101", "id": "reaction_10473908", "reactome": "R-DME-5624951", "name": "TNPO1 binds KIF17 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473892", "species_10450986" ], "products": [ "species_10473894" ], "modifiers": [], "additional_components": [ "Q9V4A1", "FBgn0039925", "FBgn0024921", "Q9VRV8", "FBgn0024921", "Q9V4A1", "FBgn0039925" ] }, "reaction_10473904": { "compartment": "compartment_18730", "id": "reaction_10473904", "reactome": "R-DME-5624948", "name": "KIF17 enters the cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473894" ], "products": [ "species_10473902" ], "modifiers": [], "additional_components": [ "Q9VRV8", "FBgn0024921", "Q9V4A1", "FBgn0039925", "Q9VRV8", "FBgn0024921", "Q9V4A1", "FBgn0039925" ] }, "reaction_10458647": { "compartment": "compartment_876", "id": "reaction_10458647", "reactome": "R-DME-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458644", "catalyst" ] ], "additional_components": [ "FBgn0029761" ] }, "reaction_10458658": { "compartment": "compartment_876", "id": "reaction_10458658", "reactome": "R-DME-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458655", "catalyst" ] ], "additional_components": [ "Q7KVW5", "FBgn0029761" ] }, "reaction_10448363": { "compartment": "compartment_70101", "id": "reaction_10448363", "reactome": "R-DME-426522", "name": "Nonendonucleolytic RISC binds exactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523", "species_10448341", "species_10448348" ], "products": [ "species_10448361" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035", "FBgn0051992", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035" ] }, "reaction_10448359": { "compartment": "compartment_70101", "id": "reaction_10448359", "reactome": "R-DME-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10448333", "catalyst" ] ], "additional_components": [ "Q32KD4", "FBgn0262739" ] }, "reaction_10448356": { "compartment": "compartment_70101", "id": "reaction_10448356", "reactome": "R-DME-426489", "name": "RISC binds inexactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448343", "species_426515", "species_10448348" ], "products": [ "species_10448354" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035", "FBgn0051992", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035" ] }, "reaction_10448329": { "compartment": "compartment_70101", "id": "reaction_10448329", "reactome": "R-DME-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10442303" ], "products": [ "species_10448326" ], "modifiers": [ [ "species_10442303", "catalyst" ] ], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739" ] }, "reaction_10464903": { "compartment": "compartment_70101", "id": "reaction_10464903", "reactome": "R-DME-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448326" ], "products": [ "species_10464891" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016" ] }, "reaction_10496968": { "compartment": "compartment_70101", "id": "reaction_10496968", "reactome": "R-DME-9023909", "name": "C3PO hydrolyzes cleaved passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496953" ], "products": [ "species_10448331" ], "modifiers": [ [ "species_10496965", "catalyst" ] ], "additional_components": [ "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739", "Q9VF77", "FBgn0038327", "Q7JVK6", "FBgn0033528" ] }, "reaction_10464901": { "compartment": "compartment_70101", "id": "reaction_10464901", "reactome": "R-DME-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464891" ], "products": [ "species_10464899" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VLW8", "FBgn0031951" ] }, "reaction_10496971": { "compartment": "compartment_70101", "id": "reaction_10496971", "reactome": "R-DME-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464877" ], "products": [ "species_10496953" ], "modifiers": [ [ "species_10464877", "catalyst" ] ], "additional_components": [ "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739" ] }, "reaction_10472623": { "compartment": "compartment_70101", "id": "reaction_10472623", "reactome": "R-DME-5578712", "name": "Importin-8 binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443060", "species_10472619" ], "products": [ "species_10472621" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "FBgn0026252", "Q9VSD6", "FBgn0026252", "Q32KD4", "FBgn0262739" ] }, "reaction_10472637": { "compartment": "compartment_70101", "id": "reaction_10472637", "reactome": "R-DME-5578744", "name": "Importin-8 imports AGO2:miRNA into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472625", "species_10472621" ], "products": [ "species_10472631", "species_10472635" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9VZ23", "FBgn0020255", "species_29438", "Q9VSD6", "FBgn0026252", "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739", "Q9VSD6", "FBgn0026252", "species_29438", "Q9VZ23", "FBgn0020255", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10472668": { "compartment": "compartment_70101", "id": "reaction_10472668", "reactome": "R-DME-5578966", "name": "TNRC6A:AGO2:miRNA is transported into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472660" ], "products": [ "species_10472666" ], "modifiers": [], "additional_components": [ "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739" ] }, "reaction_10472662": { "compartment": "compartment_70101", "id": "reaction_10472662", "reactome": "R-DME-5578965", "name": "TNRC6A binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443060", "species_10448348" ], "products": [ "species_10472660" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "FBgn0051992", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739" ] }, "reaction_10458332": { "compartment": "compartment_70101", "id": "reaction_10458332", "reactome": "R-DME-1247960", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10458319" ], "products": [ "species_29370", "species_10458329" ], "modifiers": [ [ "species_10450887", "catalyst" ] ], "additional_components": [ "FBgn0261524" ] }, "reaction_10433309": { "compartment": "compartment_7660", "id": "reaction_10433309", "reactome": "R-DME-77615", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10433302" ], "products": [ "species_76230", "species_10433306" ], "modifiers": [ [ "species_10433300", "catalyst" ] ], "additional_components": [ "Q9NII1", "FBgn0026086", "Q9NII1", "FBgn0026086", "Q9NII1", "FBgn0026086" ] }, "reaction_10465775": { "compartment": "compartment_876", "id": "reaction_10465775", "reactome": "R-DME-2424477", "name": "SOS mediated nucleotide exchange of RAS (SHC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10465772", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_209218": { "compartment": "compartment_7660", "id": "reaction_209218", "reactome": "R-DME-209218", "name": "Phosphorylated DL/DIF dimer activates transcription", "reversible": "false", "notes": "In the nucleus, phosphorylated Dorsal/Dif (DL/DIF) homodimer binds to its target genes and activates transcription.", "reactants": [ "species_214725" ], "products": [ "species_214725" ], "modifiers": [], "additional_components": [ "P15330", "dl", "P98149", "Dif", "P15330", "dl", "P98149", "Dif" ] }, "reaction_209295": { "compartment": "compartment_13231", "id": "reaction_209295", "reactome": "R-DME-209295", "name": "Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated Dorsal/Dif (DL/DIF) homodimer, now free from its cytoplasmic anchor, Cactus (CACT), is imported to the nucleus. Phosphorylation of the DL/DIF homodimer is important for its nuclear localisation.", "reactants": [ "species_214728" ], "products": [ "species_214725" ], "modifiers": [], "additional_components": [ "P15330", "dl", "P98149", "Dif", "P15330", "dl", "P98149", "Dif" ] }, "reaction_209072": { "compartment": "compartment_70101", "id": "reaction_209072", "reactome": "R-DME-209072", "name": "PLL kinase binds to TL:MYD88:TUB 'signalling complex'", "reversible": "false", "notes": "The Ser/Thr kinase Pelle (PLL) binds to the death domain of Tube (TUB) in the 'signalling complex' at the plasma membrane. On binding to TUB, PLL is activated.", "reactants": [ "species_206600", "species_206070" ], "products": [ "species_206889" ], "modifiers": [], "additional_components": [ "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214878": { "compartment": "compartment_70101", "id": "reaction_214878", "reactome": "R-DME-214878", "name": "PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex'", "reversible": "false", "notes": "The Ser/Thr kinase Pelle (PLL) binds to the death domain of Tube (TUB) in the 'signalling complex' at the plasma membrane. On binding to TUB, PLL is activated.", "reactants": [ "species_206070", "species_214743" ], "products": [ "species_214742" ], "modifiers": [], "additional_components": [ "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_10436619": { "compartment": "compartment_7660", "id": "reaction_10436619", "reactome": "R-DME-163670", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436615" ], "products": [ "species_10436617" ], "modifiers": [], "additional_components": [ "FBgn0032940", "FBgn0032940" ] }, "reaction_10436721": { "compartment": "compartment_70101", "id": "reaction_10436721", "reactome": "R-DME-164423", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436617" ], "products": [ "species_10436615" ], "modifiers": [], "additional_components": [ "FBgn0032940", "FBgn0032940" ] }, "reaction_10477549": { "compartment": "compartment_161320", "id": "reaction_10477549", "reactome": "R-DME-5690046", "name": "PPT2 hydrolyses PALMCoA to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690537", "species_1605715" ], "products": [ "species_1678675", "species_5690516" ], "modifiers": [ [ "species_10477546", "catalyst" ] ], "additional_components": [ "FBgn0032358" ] }, "reaction_10432490": { "compartment": "compartment_70101", "id": "reaction_10432490", "reactome": "R-DME-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_76183", "species_29364", "species_29508" ], "products": [ "species_29356", "species_113528", "species_29366", "species_3632881", "species_76194" ], "modifiers": [ [ "species_10432487", "catalyst" ] ], "additional_components": [ "B7Z001", "FBgn0283427" ] }, "reaction_10477738": { "compartment": "compartment_12045", "id": "reaction_10477738", "reactome": "R-DME-5690565", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10477735", "catalyst" ] ], "additional_components": [ "Q7K4Y0", "FBgn0086687" ] }, "reaction_10432425": { "compartment": "compartment_70101", "id": "reaction_10432425", "reactome": "R-DME-75849", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654", "species_198498" ], "products": [ "species_76190", "species_113544" ], "modifiers": [ [ "species_10432422", "catalyst" ] ], "additional_components": [ "FBgn0037912" ] }, "reaction_10441352": { "compartment": "compartment_70101", "id": "reaction_10441352", "reactome": "R-DME-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10432436", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "FBgn0033246" ] }, "reaction_10441469": { "compartment": "compartment_70101", "id": "reaction_10441469", "reactome": "R-DME-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10441466", "catalyst" ] ], "additional_components": [ "FBgn0036821" ] }, "reaction_10476157": { "compartment": "compartment_12045", "id": "reaction_10476157", "reactome": "R-DME-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10476154", "catalyst" ] ], "additional_components": [ "Q9VKD2", "FBgn0032394" ] }, "reaction_10453291": { "compartment": "compartment_70101", "id": "reaction_10453291", "reactome": "R-DME-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10453288", "catalyst" ] ], "additional_components": [ "Q9VV87", "FBgn0260960", "Q9VHX7", "FBgn0037534", "Q6NN18", "FBgn0034382", "Q9VCY6", "FBgn0038986", "Q9VH59", "FBgn0037761", "Q4V3H4", "FBgn0037764", "Q9VCY5", "FBgn0053110", "Q9VH58", "FBgn0037762", "A1ZBD2", "FBgn0034383", "Q9VCT3", "FBgn0039030", "Q9VH57", "FBgn0037763", "Q95T98", "FBgn0051523", "Q9VH55", "FBgn0037765", "Q8SXD1", "FBgn0050008", "Q9VCZ0", "FBgn0038983", "Q8IMY2", "FBgn0051141", "Q9VCY7", "FBgn0260942" ] }, "reaction_10479066": { "compartment": "compartment_70101", "id": "reaction_10479066", "reactome": "R-DME-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5695985", "species_76194" ], "products": [ "species_111294", "species_5695971", "species_76577" ], "modifiers": [ [ "species_10479063", "catalyst" ] ], "additional_components": [ "Q9V3S9", "FBgn0027348", "Q9V3U0", "FBgn0286723" ] }, "reaction_10479082": { "compartment": "compartment_5460", "id": "reaction_10479082", "reactome": "R-DME-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5696008", "species_113593" ], "products": [ "species_159448", "species_159450", "species_5696003" ], "modifiers": [ [ "species_10479079", "catalyst" ] ], "additional_components": [ "FBgn0029945" ] }, "reaction_10453338": { "compartment": "compartment_70101", "id": "reaction_10453338", "reactome": "R-DME-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10440266", "catalyst" ] ], "additional_components": [ "FBgn0029975" ] }, "reaction_10453335": { "compartment": "compartment_70101", "id": "reaction_10453335", "reactome": "R-DME-548815", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548794" ], "products": [ "species_113528", "species_548829", "species_76194" ], "modifiers": [ [ "species_10453327", "catalyst" ] ], "additional_components": [ "Q9VCY6", "FBgn0038986", "Q9VCY5", "FBgn0053110", "Q9VCT3", "FBgn0039030", "Q95T98", "FBgn0051523", "Q8SXD1", "FBgn0050008", "Q8IMY2", "FBgn0051141", "Q6NN18", "FBgn0034382", "Q4V3H4", "FBgn0037764", "A1ZBD2", "FBgn0034383", "Q9VHX7", "FBgn0037534", "Q9VH59", "FBgn0037761", "Q9VH58", "FBgn0037762", "Q9VH57", "FBgn0037763", "Q9VH55", "FBgn0037765", "Q9VCZ0", "FBgn0038983", "Q9VCY7", "FBgn0260942" ] }, "reaction_10453332": { "compartment": "compartment_70101", "id": "reaction_10453332", "reactome": "R-DME-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10453329", "catalyst" ] ], "additional_components": [ "Q9VCY6", "FBgn0038986", "Q9VCY5", "FBgn0053110", "Q9VCT3", "FBgn0039030", "Q95T98", "FBgn0051523", "Q8SXD1", "FBgn0050008", "Q8IMY2", "FBgn0051141", "Q6NN18", "FBgn0034382", "Q4V3H4", "FBgn0037764", "A1ZBD2", "FBgn0034383", "Q9VHX7", "FBgn0037534", "Q9VH59", "FBgn0037761", "Q9VH58", "FBgn0037762", "Q9VH57", "FBgn0037763", "Q9VH55", "FBgn0037765", "Q9VCZ0", "FBgn0038983", "Q9VCY7", "FBgn0260942", "Q9VV87", "FBgn0260960" ] }, "reaction_10453348": { "compartment": "compartment_70101", "id": "reaction_10453348", "reactome": "R-DME-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_428139", "species_29366" ], "modifiers": [ [ "species_10453343", "catalyst" ] ], "additional_components": [ "FBgn0035471" ] }, "reaction_10436643": { "compartment": "compartment_70101", "id": "reaction_10436643", "reactome": "R-DME-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432485" ], "products": [ "species_10432487" ], "modifiers": [], "additional_components": [ "FBgn0283427", "B7Z001", "FBgn0283427" ] }, "reaction_10495309": { "compartment": "compartment_5460", "id": "reaction_10495309", "reactome": "R-DME-8957389", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8957387" ], "products": [ "species_8957386", "species_113521" ], "modifiers": [ [ "species_10495306", "catalyst" ] ], "additional_components": [ "FBgn0038425" ] }, "reaction_10432417": { "compartment": "compartment_70101", "id": "reaction_10432417", "reactome": "R-DME-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_113592", "species_76194" ], "products": [ "species_29372", "species_29370", "species_76183", "species_76213" ], "modifiers": [ [ "species_10432414", "catalyst" ] ], "additional_components": [ "Q7KN85", "FBgn0020236" ] }, "reaction_10487694": { "compartment": "compartment_12045", "id": "reaction_10487694", "reactome": "R-DME-8847579", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10487691", "catalyst" ] ], "additional_components": [ "Q9VG68", "FBgn0043043", "Q9VA93", "FBgn0039755", "Q9VTD4", "FBgn0029172", "Q9VA94", "FBgn0039754", "Q7K4Y0", "FBgn0086687", "Q9VFX5", "FBgn0038130", "Q9VA92", "FBgn0039756" ] }, "reaction_10477728": { "compartment": "compartment_161320", "id": "reaction_10477728", "reactome": "R-DME-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_5690533" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10477725", "catalyst" ] ], "additional_components": [ "species_3632881", "species_6785219", "FBgn0030057" ] }, "reaction_10495043": { "compartment": "compartment_17947", "id": "reaction_10495043", "reactome": "R-DME-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495031" ], "products": [ "species_10427563", "species_10495040" ], "modifiers": [ [ "species_10495031", "catalyst" ] ], "additional_components": [ "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609" ] }, "reaction_10495033": { "compartment": "compartment_17947", "id": "reaction_10495033", "reactome": "R-DME-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495029", "species_10495027" ], "products": [ "species_10495031" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609" ] }, "reaction_10493243": { "compartment": "compartment_7660", "id": "reaction_10493243", "reactome": "R-DME-8942099", "name": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434753", "species_10467826", "species_10493239", "species_10493237", "species_10493232" ], "products": [ "species_10493241" ], "modifiers": [], "additional_components": [ "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "FBgn0001198", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0030812", "Q9VRP9", "FBgn0086694", "Q9VRP9", "FBgn0086694", "Q9VX88", "FBgn0030812", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P02283", "FBgn0001198", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637" ] }, "reaction_10493246": { "compartment": "compartment_7660", "id": "reaction_10493246", "reactome": "R-DME-8942101", "name": "RNF20:RNF40 monoubiquitinates Histone H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493241" ], "products": [ "species_10434753", "species_10488716", "species_10477560", "species_10493237", "species_10493232" ], "modifiers": [ [ "species_10493241", "catalyst" ] ], "additional_components": [ "Q9VRP9", "FBgn0086694", "Q9VX88", "FBgn0030812", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P02283", "FBgn0001198", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "FBgn0004436", "FBgn0001198", "FBgn0030812", "Q9VRP9", "FBgn0086694", "Q9VRP9", "FBgn0086694", "Q9VX88", "FBgn0030812", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P02283", "FBgn0001198", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637" ] }, "reaction_10433263": { "compartment": "compartment_7660", "id": "reaction_10433263", "reactome": "R-DME-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433237", "species_10433259" ], "products": [ "species_10433261" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186" ] }, "reaction_10433239": { "compartment": "compartment_7660", "id": "reaction_10433239", "reactome": "R-DME-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433235", "species_10433230" ], "products": [ "species_10433237" ], "modifiers": [], "additional_components": [ "FBgn0041186", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186" ] }, "reaction_10433267": { "compartment": "compartment_7660", "id": "reaction_10433267", "reactome": "R-DME-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433261" ], "products": [ "species_10433265", "species_10433259" ], "modifiers": [], "additional_components": [ "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554" ] }, "reaction_10436095": { "compartment": "compartment_12045", "id": "reaction_10436095", "reactome": "R-DME-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855667" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10436092", "catalyst" ] ], "additional_components": [ "FBgn0035464" ] }, "reaction_10436079": { "compartment": "compartment_12045", "id": "reaction_10436079", "reactome": "R-DME-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855656", "species_449229" ], "products": [ "species_8855664" ], "modifiers": [ [ "species_10436076", "catalyst" ] ], "additional_components": [ "FBgn0266438" ] }, "reaction_10436056": { "compartment": "compartment_70101", "id": "reaction_10436056", "reactome": "R-DME-162730", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_162756" ], "products": [ "species_8855657", "species_110096" ], "modifiers": [ [ "species_10436053", "catalyst" ] ], "additional_components": [ "E1JIA5", "FBgn0259933", "Q7JUM3", "FBgn0034270", "Q8MSE4", "FBgn0039405", "Q9VHX6", "FBgn0037535", "A0A2U8U156", "FBgn0035435", "Q8IR17", "FBgn0086448" ] }, "reaction_10436087": { "compartment": "compartment_12045", "id": "reaction_10436087", "reactome": "R-DME-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855659", "species_1500581" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10436084", "catalyst" ] ], "additional_components": [ "FBgn0033479" ] }, "reaction_10436103": { "compartment": "compartment_12045", "id": "reaction_10436103", "reactome": "R-DME-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855663" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10436100", "catalyst" ] ], "additional_components": [ "FBgn0265174" ] }, "reaction_10436071": { "compartment": "compartment_12045", "id": "reaction_10436071", "reactome": "R-DME-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10436068", "catalyst" ] ], "additional_components": [ "Q9VW21", "FBgn0036893", "A1Z705", "FBgn0033187" ] }, "reaction_10436004": { "compartment": "compartment_17957", "id": "reaction_10436004", "reactome": "R-DME-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_8855666", "species_76194" ], "modifiers": [ [ "species_10436001", "catalyst" ] ], "additional_components": [ "FBgn0035265" ] }, "reaction_10467548": { "compartment": "compartment_70101", "id": "reaction_10467548", "reactome": "R-DME-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467524", "species_3134861" ], "products": [ "species_10467526" ], "modifiers": [], "additional_components": [ "FBgn0032883", "Q8SWT2", "FBgn0032883" ] }, "reaction_10497380": { "compartment": "compartment_70101", "id": "reaction_10497380", "reactome": "R-DME-9604480", "name": "NFkB complex translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [ [ "species_10467540", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P24785", "FBgn0002774", "Q7K105", "MYD88" ] }, "reaction_10467546": { "compartment": "compartment_70101", "id": "reaction_10467546", "reactome": "R-DME-3134954", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467528", "species_3134861" ], "products": [ "species_10467530" ], "modifiers": [], "additional_components": [ "FBgn0002774", "P24785", "FBgn0002774" ] }, "reaction_10467544": { "compartment": "compartment_70101", "id": "reaction_10467544", "reactome": "R-DME-3134953", "name": "DHX36 or DHX9 binds MyD88", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467536", "species_10467532" ], "products": [ "species_10467542" ], "modifiers": [], "additional_components": [ "P24785", "FBgn0002774", "Q8SWT2", "FBgn0032883", "P24785", "FBgn0002774", "Q7K105", "MYD88", "Q8SWT2", "FBgn0032883" ] }, "reaction_209187": { "compartment": "compartment_70101", "id": "reaction_209187", "reactome": "R-DME-209187", "name": "Further phosphorylation of CI by CKIalphaepsilon", "reversible": "false", "notes": "Previous phosphorylation of Cubitus Interruptus (CI) at Ser852 and Ser888 primes further phosphorylation by CKIalphaepsilon (CKIalpha/DCO) at Ser855, Ser858, and Ser891.", "reactants": [ "species_113592", "species_206997" ], "products": [ "species_206766", "species_29370" ], "modifiers": [ [ "species_206577", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "P19538", "ci", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "O76324", "DCO" ] }, "reaction_209172": { "compartment": "compartment_70101", "id": "reaction_209172", "reactome": "R-DME-209172", "name": "Phosphorylation of CI by SGG", "reversible": "false", "notes": "Previous phosphorylation of Cubitus Interruptus (CI) at Ser856 and Ser892 primes Shaggy (SGG) phosphorylation at Ser884 and Ser888. Ser852 can also be phosphorylated by SGG if it hasn't been previously phosphorylated by CKIalpha/DCO.", "reactants": [ "species_206924", "species_113592" ], "products": [ "species_29370", "species_206997" ], "modifiers": [ [ "species_206898", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "P19538", "ci", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209293": { "compartment": "compartment_70101", "id": "reaction_209293", "reactome": "R-DME-209293", "name": "Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO)", "reversible": "false", "notes": "The priming phosphorylations of Cubitus Interruptus (CI) results in additional phosphorylation by kinases CKIalphaepsilon (CKIalpha/DCO) at Ser841, Ser844, Thr845, Ser849, Ser852, Ser859, Ser862, and Ser895.", "reactants": [ "species_113592", "species_206916" ], "products": [ "species_206924", "species_29370" ], "modifiers": [ [ "species_206577", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "P19538", "ci", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "O76324", "DCO" ] }, "reaction_209196": { "compartment": "compartment_70101", "id": "reaction_209196", "reactome": "R-DME-209196", "name": "Phosphorylation of CI by PKA-C1", "reversible": "false", "notes": "Cubitus Interruptus (CI) is primed for phosphorylation by Protein kinase A (PKA-C1) at Ser838, Ser856, and Ser892.", "reactants": [ "species_113592", "species_206721" ], "products": [ "species_29370", "species_206916" ], "modifiers": [ [ "species_206865", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "P19538", "ci", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "Q24170", "Phospho KSR", "P11346", "Raf", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "Q7KNQ9", "cnk", "Q8ML92", "AVE", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10457576": { "compartment": "compartment_7660", "id": "reaction_10457576", "reactome": "R-DME-997326", "name": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10454153" ], "products": [ "species_113550", "species_10457569" ], "modifiers": [ [ "species_10457573", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10448751": { "compartment": "compartment_70101", "id": "reaction_10448751", "reactome": "R-DME-428917", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10448746" ], "products": [ "species_29420", "species_10448748" ], "modifiers": [ [ "species_10448746", "catalyst" ] ], "additional_components": [ "CHEBI:15627", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "CHEBI:15627", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P25157", "FBgn0000384", "species_29438", "CHEBI:15627", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10448722": { "compartment": "compartment_70101", "id": "reaction_10448722", "reactome": "R-DME-428750", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10448717" ], "products": [ "species_29420", "species_10448719" ], "modifiers": [ [ "species_10448717", "catalyst" ] ], "additional_components": [ "CHEBI:15627", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "CHEBI:15627", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "CHEBI:15627", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10446811": { "compartment": "compartment_70101", "id": "reaction_10446811", "reactome": "R-DME-392195", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10446806" ], "products": [ "species_29420", "species_10446808" ], "modifiers": [ [ "species_10446806", "catalyst" ] ], "additional_components": [ "species_29370", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P20353", "FBgn0001104", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29370", "species_29370", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10448755": { "compartment": "compartment_70101", "id": "reaction_10448755", "reactome": "R-DME-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448753", "species_113592" ], "products": [ "species_29370", "species_10439430" ], "modifiers": [ [ "species_10434217", "catalyst" ] ], "additional_components": [ "FBgn0024846", "FBgn0024846", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10447584": { "compartment": "compartment_70101", "id": "reaction_10447584", "reactome": "R-DME-418662", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440003" ], "products": [ "species_10447582" ], "modifiers": [], "additional_components": [ "FBgn0262733", "FBgn0262733" ] }, "reaction_10433304": { "compartment": "compartment_7660", "id": "reaction_10433304", "reactome": "R-DME-77613", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10433300" ], "products": [ "species_10433302" ], "modifiers": [], "additional_components": [ "Q9NII1", "FBgn0026086", "Q9NII1", "FBgn0026086" ] }, "reaction_10434102": { "compartment": "compartment_7660", "id": "reaction_10434102", "reactome": "R-DME-111238", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433298" ], "products": [ "species_10433300" ], "modifiers": [], "additional_components": [ "FBgn0026086", "Q9NII1", "FBgn0026086" ] }, "reaction_10455818": { "compartment": "compartment_20699", "id": "reaction_10455818", "reactome": "R-DME-975829", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975819" ], "products": [ "species_205687", "species_975822" ], "modifiers": [ [ "species_10455815", "catalyst" ] ], "additional_components": [ "FBgn0039738" ] }, "reaction_10479784": { "compartment": "compartment_20699", "id": "reaction_10479784", "reactome": "R-DME-6786048", "name": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_6786371" ], "products": [ "species_742343", "species_6786380" ], "modifiers": [ [ "species_10479781", "catalyst" ] ], "additional_components": [ "Q8IRG5", "FBgn0035287", "Q9VMS3", "FBgn0031697", "Q9VJG5", "FBgn0032618" ] }, "reaction_10457715": { "compartment": "compartment_20699", "id": "reaction_10457715", "reactome": "R-DME-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10457712", "catalyst" ] ], "additional_components": [ "FBgn0030327" ] }, "reaction_10478179": { "compartment": "compartment_161320", "id": "reaction_10478179", "reactome": "R-DME-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10478176", "catalyst" ] ], "additional_components": [ "Q9VTJ4", "FBgn0285958" ] }, "reaction_10455810": { "compartment": "compartment_20699", "id": "reaction_10455810", "reactome": "R-DME-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_964752", "species_975819" ], "modifiers": [ [ "species_10455807", "catalyst" ] ], "additional_components": [ "Q9VF33", "FBgn0026616", "species_1562550", "Q24451", "FBgn0011740" ] }, "reaction_10455908": { "compartment": "compartment_17963", "id": "reaction_10455908", "reactome": "R-DME-975926", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981613" ], "modifiers": [ [ "species_10455905", "catalyst" ] ], "additional_components": [ "FBgn0051849" ] }, "reaction_10440636": { "compartment": "compartment_70101", "id": "reaction_10440636", "reactome": "R-DME-196350", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_29360" ], "products": [ "species_70106", "species_196344", "species_73473" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10440208": { "compartment": "compartment_70101", "id": "reaction_10440208", "reactome": "R-DME-193052", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196344" ], "products": [ "species_193055" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10493825": { "compartment": "compartment_7660", "id": "reaction_10493825", "reactome": "R-DME-8952058", "name": "CCND1 binds RUNX3 and displaces EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493737", "species_10457979" ], "products": [ "species_10493823", "species_10458126" ], "modifiers": [], "additional_components": [ "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "FBgn0010315", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "FBgn0261617" ] }, "reaction_10493829": { "compartment": "compartment_7660", "id": "reaction_10493829", "reactome": "R-DME-8952062", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493823", "species_10469978" ], "products": [ "species_10493827" ], "modifiers": [], "additional_components": [ "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "FBgn0041210", "M9PHQ2", "FBgn0041210", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656" ] }, "reaction_10493721": { "compartment": "compartment_7660", "id": "reaction_10493721", "reactome": "R-DME-8951966", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493708", "species_113560" ], "products": [ "species_2485002", "species_10493718" ], "modifiers": [ [ "species_10493708", "catalyst" ], [ "species_10437860", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10493834": { "compartment": "compartment_7660", "id": "reaction_10493834", "reactome": "R-DME-8952069", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10493827" ], "products": [ "species_427486", "species_10493735", "species_10493831" ], "modifiers": [ [ "species_10493827", "catalyst" ] ], "additional_components": [ "M9PHQ2", "FBgn0041210", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "Q7KUZ5", "FBgn0010315", "M9PHQ2", "FBgn0041210", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "M9PHQ2", "FBgn0041210", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656" ] }, "reaction_10493739": { "compartment": "compartment_7660", "id": "reaction_10493739", "reactome": "R-DME-8951977", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493735", "species_10493718" ], "products": [ "species_10493737" ], "modifiers": [ [ "species_206703", "catalyst" ] ], "additional_components": [ "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "P08646", "RAS85D", "species_29438" ] }, "reaction_10493710": { "compartment": "compartment_7660", "id": "reaction_10493710", "reactome": "R-DME-8951951", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489803", "species_10458126" ], "products": [ "species_10493708" ], "modifiers": [], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "FBgn0261617", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981" ] }, "reaction_10449032": { "compartment": "compartment_70101", "id": "reaction_10449032", "reactome": "R-DME-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429926" ], "products": [ "species_430042", "species_429925" ], "modifiers": [ [ "species_10449029", "catalyst" ] ], "additional_components": [ "FBgn0037372" ] }, "reaction_10478392": { "compartment": "compartment_70101", "id": "reaction_10478392", "reactome": "R-DME-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_430042" ], "products": [ "species_29372", "species_5694090" ], "modifiers": [ [ "species_10478389", "catalyst" ] ], "additional_components": [ "FBgn0034988" ] }, "reaction_10449126": { "compartment": "compartment_70101", "id": "reaction_10449126", "reactome": "R-DME-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429974" ], "products": [ "species_109402", "species_113578", "species_109395", "species_429926", "species_76577" ], "modifiers": [ [ "species_10449123", "catalyst" ] ], "additional_components": [ "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9XZ19", "FBgn0027524", "Q6NNB2", "FBgn0033376", "Q9VCH8", "FBgn0039117", "Q9W074", "FBgn0042712" ] }, "reaction_10492020": { "compartment": "compartment_7660", "id": "reaction_10492020", "reactome": "R-DME-8934735", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10491997" ], "products": [ "species_77502", "species_10492017" ], "modifiers": [ [ "species_10491997", "catalyst" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834" ] }, "reaction_10492022": { "compartment": "compartment_7660", "id": "reaction_10492022", "reactome": "R-DME-8934742", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467587", "species_10489794" ], "products": [ "species_10491997" ], "modifiers": [], "additional_components": [ "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834" ] }, "reaction_10492150": { "compartment": "compartment_7660", "id": "reaction_10492150", "reactome": "R-DME-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492130" ], "products": [ "species_77502", "species_10492147" ], "modifiers": [ [ "species_10492130", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10492198": { "compartment": "compartment_7660", "id": "reaction_10492198", "reactome": "R-DME-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492193" ], "products": [ "species_77502", "species_10492195" ], "modifiers": [ [ "species_10492193", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10492189": { "compartment": "compartment_7660", "id": "reaction_10492189", "reactome": "R-DME-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492184" ], "products": [ "species_77502", "species_10492186" ], "modifiers": [ [ "species_10492184", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10492159": { "compartment": "compartment_7660", "id": "reaction_10492159", "reactome": "R-DME-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492154" ], "products": [ "species_77502", "species_10492156" ], "modifiers": [ [ "species_10492154", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10468106": { "compartment": "compartment_70101", "id": "reaction_10468106", "reactome": "R-DME-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468104" ], "products": [ "species_29370", "species_10468092" ], "modifiers": [], "additional_components": [] }, "reaction_10468102": { "compartment": "compartment_70101", "id": "reaction_10468102", "reactome": "R-DME-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468092" ], "products": [ "species_10468094" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10468100": { "compartment": "compartment_70101", "id": "reaction_10468100", "reactome": "R-DME-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468094" ], "products": [ "species_10468098" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10430845": { "compartment": "compartment_70101", "id": "reaction_10430845", "reactome": "R-DME-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430513", "species_72617", "species_10430440", "species_10430457", "species_10430508" ], "products": [ "species_10430513", "species_72617", "species_10430440", "species_10430457", "species_10430508" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "FBgn0030719", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0030719", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10430519": { "compartment": "compartment_70101", "id": "reaction_10430519", "reactome": "R-DME-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430508" ], "products": [ "species_29372", "species_29370", "species_10430508" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10464559": { "compartment": "compartment_7660", "id": "reaction_10464559", "reactome": "R-DME-2032794", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464550", "species_10464555", "species_10464523" ], "products": [ "species_10464557" ], "modifiers": [], "additional_components": [ "FBgn0020388", "FBgn0021767", "Q9W3F4", "FBgn0021767", "Q45VV3", "yki", "Q9VTZ1", "FBgn0020388" ] }, "reaction_10490929": { "compartment": "compartment_7660", "id": "reaction_10490929", "reactome": "R-DME-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10464537" ], "products": [ "species_10490927" ], "modifiers": [], "additional_components": [ "P30052", "sd", "Q45VV3", "yki" ] }, "reaction_10490933": { "compartment": "compartment_7660", "id": "reaction_10490933", "reactome": "R-DME-8871265", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10464541" ], "products": [ "species_10490931" ], "modifiers": [], "additional_components": [ "P30052", "sd", "Q45VV3", "yki" ] }, "reaction_10464535": { "compartment": "compartment_7660", "id": "reaction_10464535", "reactome": "R-DME-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464531", "species_10458548" ], "products": [ "species_10464533" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_10490937": { "compartment": "compartment_7660", "id": "reaction_10490937", "reactome": "R-DME-8871266", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10464539" ], "products": [ "species_10490935" ], "modifiers": [], "additional_components": [ "P30052", "sd", "Q45VV3", "yki" ] }, "reaction_10464545": { "compartment": "compartment_7660", "id": "reaction_10464545", "reactome": "R-DME-2032781", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464531", "species_10464523" ], "products": [ "species_10464543" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_10440633": { "compartment": "compartment_70101", "id": "reaction_10440633", "reactome": "R-DME-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196095", "species_70106", "species_29364" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10440630", "catalyst" ] ], "additional_components": [ "FBgn0086254" ] }, "reaction_10433192": { "compartment": "compartment_5460", "id": "reaction_10433192", "reactome": "R-DME-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77313", "species_113521" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433202": { "compartment": "compartment_5460", "id": "reaction_10433202", "reactome": "R-DME-77319", "name": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77318" ], "products": [ "species_31649", "species_77313" ], "modifiers": [ [ "species_10433199", "catalyst" ] ], "additional_components": [ "Q9VDT1", "FBgn0038742" ] }, "reaction_10435438": { "compartment": "compartment_17951", "id": "reaction_10435438", "reactome": "R-DME-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141349" ], "products": [ "species_141327", "species_113575", "species_141350" ], "modifiers": [ [ "species_10435435", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VHN8", "FBgn0037606" ] }, "reaction_10435428": { "compartment": "compartment_17951", "id": "reaction_10435428", "reactome": "R-DME-141341", "name": "SMOX-3 oxidises SPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141342" ], "products": [ "species_141324", "species_113575", "species_141328" ], "modifiers": [ [ "species_10435425", "catalyst" ] ], "additional_components": [ "FBgn0036749" ] }, "reaction_10444066": { "compartment": "compartment_70101", "id": "reaction_10444066", "reactome": "R-DME-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10444061", "catalyst" ] ], "additional_components": [ "FBgn0038302" ] }, "reaction_10444064": { "compartment": "compartment_70101", "id": "reaction_10444064", "reactome": "R-DME-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10444061", "catalyst" ] ], "additional_components": [ "FBgn0038302" ] }, "reaction_10435440": { "compartment": "compartment_17951", "id": "reaction_10435440", "reactome": "R-DME-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141323" ], "products": [ "species_141324", "species_141327", "species_113575" ], "modifiers": [ [ "species_10435435", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VHN8", "FBgn0037606" ] }, "reaction_10454399": { "compartment": "compartment_70101", "id": "reaction_10454399", "reactome": "R-DME-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_29432", "species_893615" ], "modifiers": [ [ "species_10454393", "catalyst" ], [ "species_29502", "inhibitor" ], [ "species_8939576", "inhibitor" ] ], "additional_components": [ "Q8SXC2", "FBgn0037955", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10490481": { "compartment": "compartment_876", "id": "reaction_10490481", "reactome": "R-DME-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10490478", "catalyst" ] ], "additional_components": [ "Q8IQF3", "FBgn0052081", "Q9VLM3", "FBgn0032036", "Q9VT04", "FBgn0036007", "Q9VTD5", "FBgn0052079", "M9PEU1", "FBgn0263776", "Q9VTD7", "FBgn0036116", "M9PHT8", "FBgn0030817", "Q9VX84", "FBgn0030816", "Q4V5R4", "FBgn0033572", "Q9W056", "FBgn0035300", "Q7K2W3", "FBgn0033760" ] }, "reaction_10428730": { "compartment": "compartment_70101", "id": "reaction_10428730", "reactome": "R-DME-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10428727", "catalyst" ] ], "additional_components": [ "species_71185", "P20351", "FBgn0003965" ] }, "reaction_10428738": { "compartment": "compartment_70101", "id": "reaction_10428738", "reactome": "R-DME-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10428735", "catalyst" ] ], "additional_components": [ "FBgn0000337" ] }, "reaction_10426991": { "compartment": "compartment_70101", "id": "reaction_10426991", "reactome": "R-DME-68712", "name": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10426958" ], "products": [ "species_10426956", "species_10426989" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7JVY2", "FBgn0000996", "Q7JX41", "FBgn0033081", "FBgn0000996", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7JX41", "FBgn0033081" ] }, "reaction_10427212": { "compartment": "compartment_7660", "id": "reaction_10427212", "reactome": "R-DME-68826", "name": "Free CDT1 associates with CDC6:ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426944", "species_10427208" ], "products": [ "species_10427210" ], "modifiers": [], "additional_components": [ "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "FBgn0000996", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918" ] }, "reaction_10427206": { "compartment": "compartment_70101", "id": "reaction_10427206", "reactome": "R-DME-68825", "name": "Ubiquitinated geminin is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426989" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7JX41", "FBgn0033081", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10491189": { "compartment": "compartment_17927", "id": "reaction_10491189", "reactome": "R-DME-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10491186", "catalyst" ] ], "additional_components": [ "FBgn0037852" ] }, "reaction_10441188": { "compartment": "compartment_876", "id": "reaction_10441188", "reactome": "R-DME-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10441185", "catalyst" ] ], "additional_components": [ "Q9VGV5", "FBgn0037846", "Q9VK64", "FBgn0032449", "Q9VGV6", "FBgn0037845" ] }, "reaction_10440656": { "compartment": "compartment_70101", "id": "reaction_10440656", "reactome": "R-DME-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10440653", "catalyst" ] ], "additional_components": [ "Q8T4A5", "FBgn0037942", "species_29926" ] }, "reaction_10440685": { "compartment": "compartment_70101", "id": "reaction_10440685", "reactome": "R-DME-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73524" ], "products": [ "species_111294", "species_29386" ], "modifiers": [ [ "species_10440682", "catalyst" ] ], "additional_components": [ "FBgn0030431" ] }, "reaction_10467560": { "compartment": "compartment_70101", "id": "reaction_10467560", "reactome": "R-DME-3165230", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3165253" ], "products": [ "species_196931" ], "modifiers": [ [ "species_10467553", "catalyst" ], [ "species_73524", "inhibitor" ], [ "species_29386", "inhibitor" ] ], "additional_components": [ "FBgn0039882" ] }, "reaction_10440695": { "compartment": "compartment_70101", "id": "reaction_10440695", "reactome": "R-DME-196964", "name": "RFK:Mg2+ phosphorylates RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196931" ], "products": [ "species_29370", "species_73524" ], "modifiers": [ [ "species_10440692", "catalyst" ] ], "additional_components": [ "species_29926", "O76206", "FBgn0014930" ] }, "reaction_10455535": { "compartment": "compartment_70101", "id": "reaction_10455535", "reactome": "R-DME-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965053" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10455530", "catalyst" ] ], "additional_components": [ "species_1562550", "Q7KUC2", "FBgn0085484" ] }, "reaction_10455533": { "compartment": "compartment_70101", "id": "reaction_10455533", "reactome": "R-DME-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10455530", "catalyst" ] ], "additional_components": [ "species_1562550", "Q7KUC2", "FBgn0085484" ] }, "reaction_10455549": { "compartment": "compartment_70101", "id": "reaction_10455549", "reactome": "R-DME-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965146" ], "products": [ "species_29390", "species_31633", "species_29408" ], "modifiers": [ [ "species_10455544", "catalyst" ] ], "additional_components": [ "species_76629", "Q9VHZ5", "FBgn0051472" ] }, "reaction_10455547": { "compartment": "compartment_70101", "id": "reaction_10455547", "reactome": "R-DME-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_964952" ], "products": [ "species_29390", "species_29408" ], "modifiers": [ [ "species_10455544", "catalyst" ] ], "additional_components": [ "species_76629", "Q9VHZ5", "FBgn0051472" ] }, "reaction_10467575": { "compartment": "compartment_70101", "id": "reaction_10467575", "reactome": "R-DME-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10467572", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "species_113596", "P10351", "FBgn0003308" ] }, "reaction_10455537": { "compartment": "compartment_70101", "id": "reaction_10455537", "reactome": "R-DME-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965131" ], "products": [ "species_29390", "species_29370" ], "modifiers": [ [ "species_10455530", "catalyst" ] ], "additional_components": [ "species_1562550", "Q7KUC2", "FBgn0085484" ] }, "reaction_10467320": { "compartment": "compartment_876", "id": "reaction_10467320", "reactome": "R-DME-3000103", "name": "CUBN:AMN binds GIF:Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467316", "species_10443525" ], "products": [ "species_10467318" ], "modifiers": [], "additional_components": [ "species_3000239", "Q9W4K2", "FBgn0029708", "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467416": { "compartment": "compartment_70101", "id": "reaction_10467416", "reactome": "R-DME-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_3000241", "species_113592" ], "products": [ "species_29372", "species_29370", "species_3000125" ], "modifiers": [ [ "species_10443830", "catalyst" ] ], "additional_components": [ "FBgn0032456" ] }, "reaction_10467352": { "compartment": "compartment_161320", "id": "reaction_10467352", "reactome": "R-DME-3000263", "name": "TCII:Cbl is degraded to release Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467328" ], "products": [ "species_3000239" ], "modifiers": [], "additional_components": [ "Q9W4K2", "FBgn0029708", "species_3000239" ] }, "reaction_10467350": { "compartment": "compartment_17940", "id": "reaction_10467350", "reactome": "R-DME-3000247", "name": "Endosomal GIF:Cbl translocates to lysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467342" ], "products": [ "species_10467348" ], "modifiers": [], "additional_components": [ "species_3000239", "Q9W4K2", "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467332": { "compartment": "compartment_984", "id": "reaction_10467332", "reactome": "R-DME-3000120", "name": "GIF binds Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467314", "species_3000125" ], "products": [ "species_10467316" ], "modifiers": [], "additional_components": [ "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467507": { "compartment": "compartment_984", "id": "reaction_10467507", "reactome": "R-DME-3132759", "name": "TCN1 binds Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3132775", "species_10467503" ], "products": [ "species_10467505", "species_3132772" ], "modifiers": [], "additional_components": [ "species_3000239", "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467891": { "compartment": "compartment_984", "id": "reaction_10467891", "reactome": "R-DME-3245898", "name": "TCN1 binds Cbl in the circulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467503", "species_3000125" ], "products": [ "species_10467505" ], "modifiers": [], "additional_components": [ "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467330": { "compartment": "compartment_17940", "id": "reaction_10467330", "reactome": "R-DME-3000112", "name": "Endosomal TCII:Cbl translocates to lysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467324" ], "products": [ "species_10467328" ], "modifiers": [], "additional_components": [ "species_3000239", "Q9W4K2", "FBgn0029708", "Q9W4K2", "FBgn0029708", "species_3000239" ] }, "reaction_10467344": { "compartment": "compartment_984", "id": "reaction_10467344", "reactome": "R-DME-3000137", "name": "CUBN:AMN transports extracellular GIF:Cbl to endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467318" ], "products": [ "species_10467338", "species_10467342" ], "modifiers": [], "additional_components": [ "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "species_3000239", "Q9W4K2", "FBgn0029708", "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467312": { "compartment": "compartment_984", "id": "reaction_10467312", "reactome": "R-DME-3000074", "name": "TCII binds Cbl in the circulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467308", "species_3000125" ], "products": [ "species_10467310" ], "modifiers": [], "additional_components": [ "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10440735": { "compartment": "compartment_70101", "id": "reaction_10440735", "reactome": "R-DME-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_197256", "species_113592", "species_29472" ], "products": [ "species_111294", "species_29404", "species_76577", "species_29360" ], "modifiers": [ [ "species_10440732", "catalyst" ] ], "additional_components": [ "Q9VYA0", "FBgn0030512" ] }, "reaction_10441342": { "compartment": "compartment_5460", "id": "reaction_10441342", "reactome": "R-DME-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938078", "species_8938090" ], "modifiers": [ [ "species_10441339", "catalyst" ] ], "additional_components": [ "Q9VC03", "FBgn0039254", "species_29926" ] }, "reaction_10490435": { "compartment": "compartment_70101", "id": "reaction_10490435", "reactome": "R-DME-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10490432", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10490440": { "compartment": "compartment_70101", "id": "reaction_10490440", "reactome": "R-DME-8869607", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10490437", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10440725": { "compartment": "compartment_70101", "id": "reaction_10440725", "reactome": "R-DME-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10440722", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VC03", "FBgn0039254" ] }, "reaction_10490443": { "compartment": "compartment_70101", "id": "reaction_10490443", "reactome": "R-DME-8869627", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10490437", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10492619": { "compartment": "compartment_984", "id": "reaction_10492619", "reactome": "R-DME-8940070", "name": "NT5E:Zn2+ hydrolyses NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352330", "species_109276" ], "products": [ "species_109277", "species_8940067" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10492621": { "compartment": "compartment_984", "id": "reaction_10492621", "reactome": "R-DME-8940074", "name": "NT5E:Zn2+ hydrolyses NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8940067" ], "products": [ "species_109277", "species_8940077" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10490446": { "compartment": "compartment_70101", "id": "reaction_10490446", "reactome": "R-DME-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10490432", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10440715": { "compartment": "compartment_70101", "id": "reaction_10440715", "reactome": "R-DME-197198", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29360" ], "products": [ "species_29370", "species_29366" ], "modifiers": [ [ "species_10440712", "catalyst" ] ], "additional_components": [ "species_1562550", "Q6IDH2", "FBgn0033853" ] }, "reaction_10492564": { "compartment": "compartment_70101", "id": "reaction_10492564", "reactome": "R-DME-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10440722", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VC03", "FBgn0039254" ] }, "reaction_10486272": { "compartment": "compartment_5460", "id": "reaction_10486272", "reactome": "R-DME-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6807477" ], "products": [ "species_113548", "species_113581", "species_113529", "species_113600" ], "modifiers": [ [ "species_10486269", "catalyst" ] ], "additional_components": [ "FBgn0036848" ] }, "reaction_10492311": { "compartment": "compartment_70101", "id": "reaction_10492311", "reactome": "R-DME-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938276", "species_29360" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10492304", "catalyst" ] ], "additional_components": [ "FBgn0034129" ] }, "reaction_10486264": { "compartment": "compartment_5460", "id": "reaction_10486264", "reactome": "R-DME-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10486261", "catalyst" ] ], "additional_components": [ "Q9W2Y3", "FBgn0030178" ] }, "reaction_10490427": { "compartment": "compartment_876", "id": "reaction_10490427", "reactome": "R-DME-8869603", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869604" ], "products": [ "species_197230" ], "modifiers": [ [ "species_10490424", "catalyst" ] ], "additional_components": [ "FBgn0086365" ] }, "reaction_10440705": { "compartment": "compartment_70101", "id": "reaction_10440705", "reactome": "R-DME-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_197230", "species_70106" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10440702", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VQX4", "FBgn0031589" ] }, "reaction_10441349": { "compartment": "compartment_7660", "id": "reaction_10441349", "reactome": "R-DME-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200492", "species_29358" ], "products": [ "species_8878981", "species_200499" ], "modifiers": [ [ "species_10441346", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VC03", "FBgn0039254" ] }, "reaction_10440974": { "compartment": "compartment_876", "id": "reaction_10440974", "reactome": "R-DME-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10440971", "catalyst" ] ], "additional_components": [ "Q7KK97", "FBgn0028563", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562" ] }, "reaction_10441014": { "compartment": "compartment_70101", "id": "reaction_10441014", "reactome": "R-DME-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10441000" ], "products": [ "species_10440998", "species_198816" ], "modifiers": [ [ "species_10441000", "catalyst" ] ], "additional_components": [ "species_71185", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "CHEBI:36144", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "species_71185", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575" ] }, "reaction_10441011": { "compartment": "compartment_70101", "id": "reaction_10441011", "reactome": "R-DME-198824", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10440998", "species_73473" ], "products": [ "species_10441000", "species_29360" ], "modifiers": [ [ "species_10441008", "catalyst" ] ], "additional_components": [ "CHEBI:36144", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "species_71185", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "X2JGK6", "FBgn0036211", "species_113596" ] }, "reaction_10440945": { "compartment": "compartment_70101", "id": "reaction_10440945", "reactome": "R-DME-198813", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_198827" ], "products": [ "species_198816", "species_111745" ], "modifiers": [ [ "species_10440942", "catalyst" ] ], "additional_components": [ "Q9VSL6", "FBgn0035907", "Q9VSL5", "FBgn0035906", "Q9VSL3", "FBgn0086348", "Q9VSL2", "FBgn0035904" ] }, "reaction_10441024": { "compartment": "compartment_876", "id": "reaction_10441024", "reactome": "R-DME-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198836", "species_74113" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10441019", "catalyst" ] ], "additional_components": [ "FBgn0037807" ] }, "reaction_10441433": { "compartment": "compartment_70101", "id": "reaction_10441433", "reactome": "R-DME-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10441430", "catalyst" ] ], "additional_components": [ "Q9VTI0", "FBgn0036157" ] }, "reaction_10441362": { "compartment": "compartment_70101", "id": "reaction_10441362", "reactome": "R-DME-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10486575": { "compartment": "compartment_5460", "id": "reaction_10486575", "reactome": "R-DME-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_6808499", "species_113521" ], "products": [ "species_113529", "species_200679", "species_113600", "species_29376" ], "modifiers": [ [ "species_10486572", "catalyst" ] ], "additional_components": [ "Q9VIC9", "FBgn0032945" ] }, "reaction_10441423": { "compartment": "compartment_70101", "id": "reaction_10441423", "reactome": "R-DME-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_29356", "species_200640" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441420": { "compartment": "compartment_876", "id": "reaction_10441420", "reactome": "R-DME-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10441417", "catalyst" ] ], "additional_components": [ "Q9VK64", "FBgn0032449", "Q9VGV6", "FBgn0037845", "Q9VGV5", "FBgn0037846" ] }, "reaction_10479244": { "compartment": "compartment_5460", "id": "reaction_10479244", "reactome": "R-DME-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801451", "species_200671", "species_113593" ], "products": [ "species_113548", "species_113581", "species_5389850" ], "modifiers": [ [ "species_10479241", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10486583": { "compartment": "compartment_70101", "id": "reaction_10486583", "reactome": "R-DME-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10486580", "catalyst" ] ], "additional_components": [ "Q9VIC9", "FBgn0032945" ] }, "reaction_10485817": { "compartment": "compartment_5460", "id": "reaction_10485817", "reactome": "R-DME-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_5693984" ], "products": [ "species_6801458", "species_29362" ], "modifiers": [ [ "species_10485812", "catalyst" ] ], "additional_components": [ "FBgn0010222" ] }, "reaction_10441409": { "compartment": "compartment_70101", "id": "reaction_10441409", "reactome": "R-DME-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10428758", "catalyst" ] ], "additional_components": [ "Q9W457", "FBgn0029823" ] }, "reaction_10441407": { "compartment": "compartment_876", "id": "reaction_10441407", "reactome": "R-DME-200646", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965" ], "products": [ "species_200716" ], "modifiers": [ [ "species_10441404", "catalyst" ] ], "additional_components": [ "B7YZU3", "FBgn0033387", "Q8INF8", "FBgn0051321", "Q9VY22", "FBgn0030576", "A1Z7R6", "FBgn0033388", "Q1EC10", "FBgn0050345", "Q9VA14", "FBgn0039817", "Q0E8E1", "FBgn0260388", "Q961H2", "FBgn0050344" ] }, "reaction_10485825": { "compartment": "compartment_70101", "id": "reaction_10485825", "reactome": "R-DME-6801342", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803257", "species_113592" ], "products": [ "species_29372", "species_70106", "species_29370", "species_200640" ], "modifiers": [ [ "species_10485822", "catalyst" ] ], "additional_components": [ "FBgn0085453" ] }, "reaction_10485827": { "compartment": "compartment_5460", "id": "reaction_10485827", "reactome": "R-DME-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_5389850" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10479241", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10485830": { "compartment": "compartment_5460", "id": "reaction_10485830", "reactome": "R-DME-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801458", "species_113521" ], "products": [ "species_5389850" ], "modifiers": [ [ "species_10485812", "catalyst" ] ], "additional_components": [ "FBgn0010222" ] }, "reaction_10441461": { "compartment": "compartment_70101", "id": "reaction_10441461", "reactome": "R-DME-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_200640" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441459": { "compartment": "compartment_70101", "id": "reaction_10441459", "reactome": "R-DME-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10428758", "catalyst" ] ], "additional_components": [ "Q9W457", "FBgn0029823" ] }, "reaction_10441457": { "compartment": "compartment_876", "id": "reaction_10441457", "reactome": "R-DME-200729", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200716" ], "products": [ "species_197965" ], "modifiers": [ [ "species_10441404", "catalyst" ] ], "additional_components": [ "B7YZU3", "FBgn0033387", "Q8INF8", "FBgn0051321", "Q9VY22", "FBgn0030576", "A1Z7R6", "FBgn0033388", "Q1EC10", "FBgn0050345", "Q9VA14", "FBgn0039817", "Q0E8E1", "FBgn0260388", "Q961H2", "FBgn0050344" ] }, "reaction_10440753": { "compartment": "compartment_70101", "id": "reaction_10440753", "reactome": "R-DME-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73604", "species_29364" ], "products": [ "species_111355", "species_29366" ], "modifiers": [ [ "species_10440748", "catalyst" ] ], "additional_components": [ "FBgn0004087" ] }, "reaction_10440751": { "compartment": "compartment_70101", "id": "reaction_10440751", "reactome": "R-DME-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10440748", "catalyst" ] ], "additional_components": [ "FBgn0004087" ] }, "reaction_10441455": { "compartment": "compartment_70616", "id": "reaction_10441455", "reactome": "R-DME-200720", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671" ], "products": [ "species_111355" ], "modifiers": [ [ "species_10441438", "catalyst" ] ], "additional_components": [ "FBgn0033391" ] }, "reaction_10441453": { "compartment": "compartment_70101", "id": "reaction_10441453", "reactome": "R-DME-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441451": { "compartment": "compartment_70101", "id": "reaction_10441451", "reactome": "R-DME-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29372", "species_29370", "species_111353" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441448": { "compartment": "compartment_5460", "id": "reaction_10441448", "reactome": "R-DME-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_113593", "species_113552" ], "products": [ "species_113548", "species_113581", "species_200679" ], "modifiers": [ [ "species_10441445", "catalyst" ] ], "additional_components": [ "FBgn0030407" ] }, "reaction_10440743": { "compartment": "compartment_70101", "id": "reaction_10440743", "reactome": "R-DME-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111355", "species_113592" ], "products": [ "species_29372", "species_29370", "species_197969" ], "modifiers": [ [ "species_10440740", "catalyst" ] ], "additional_components": [ "FBgn0030407" ] }, "reaction_10441443": { "compartment": "compartment_70101", "id": "reaction_10441443", "reactome": "R-DME-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_200665", "species_113592" ], "products": [ "species_29372", "species_29370", "species_174404" ], "modifiers": [ [ "species_10440740", "catalyst" ] ], "additional_components": [ "FBgn0030407" ] }, "reaction_10498781": { "compartment": "compartment_70101", "id": "reaction_10498781", "reactome": "R-DME-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10498778", "catalyst" ] ], "additional_components": [ "P17719", "FBgn0004087" ] }, "reaction_10469673": { "compartment": "compartment_5460", "id": "reaction_10469673", "reactome": "R-DME-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3065953" ], "products": [ "species_29582", "species_29444" ], "modifiers": [ [ "species_10469670", "catalyst" ] ], "additional_components": [ "FBgn0040069" ] }, "reaction_10468376": { "compartment": "compartment_70101", "id": "reaction_10468376", "reactome": "R-DME-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468374" ], "products": [ "species_10467405" ], "modifiers": [], "additional_components": [ "Q0E9E2", "FBgn0027580", "species_266099", "Q9V9T5", "FBgn0039877", "Q9V9A7", "FBgn0042083", "Q0E9E2", "FBgn0027580", "species_266099", "Q9V9T5", "FBgn0039877", "Q9V9A7", "FBgn0042083" ] }, "reaction_10467413": { "compartment": "compartment_984", "id": "reaction_10467413", "reactome": "R-DME-3076905", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3076887" ], "products": [ "species_199238", "species_351991" ], "modifiers": [ [ "species_10467410", "catalyst" ] ], "additional_components": [ "FBgn0040069" ] }, "reaction_10441069": { "compartment": "compartment_70101", "id": "reaction_10441069", "reactome": "R-DME-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441061", "species_76194" ], "products": [ "species_10432485", "species_158466" ], "modifiers": [ [ "species_10441066", "catalyst" ] ], "additional_components": [ "FBgn0283427", "FBgn0283427", "FBgn0052099" ] }, "reaction_10440669": { "compartment": "compartment_70101", "id": "reaction_10440669", "reactome": "R-DME-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10440666", "catalyst" ] ], "additional_components": [ "species_76629", "Q8MKK3", "FBgn0050290" ] }, "reaction_10440646": { "compartment": "compartment_70101", "id": "reaction_10440646", "reactome": "R-DME-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_111294", "species_196778" ], "modifiers": [ [ "species_10440643", "catalyst" ] ], "additional_components": [ "FBgn0035632" ] }, "reaction_10440677": { "compartment": "compartment_70101", "id": "reaction_10440677", "reactome": "R-DME-196857", "name": "PANK2 phosphorylates PanK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196820" ], "products": [ "species_29370", "species_196786" ], "modifiers": [ [ "species_10440674", "catalyst" ] ], "additional_components": [ "FBgn0011205" ] }, "reaction_10441076": { "compartment": "compartment_70101", "id": "reaction_10441076", "reactome": "R-DME-199203", "name": "PANK1/3/4 phosphorylate PanK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196820" ], "products": [ "species_29370", "species_196786" ], "modifiers": [ [ "species_10441071", "catalyst" ] ], "additional_components": [ "FBgn0011205" ] }, "reaction_10440659": { "compartment": "compartment_70101", "id": "reaction_10440659", "reactome": "R-DME-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_29370", "species_76194" ], "modifiers": [ [ "species_10440643", "catalyst" ] ], "additional_components": [ "FBgn0035632" ] }, "reaction_10455438": { "compartment": "compartment_70101", "id": "reaction_10455438", "reactome": "R-DME-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947561", "species_947496" ], "products": [ "species_111294", "species_947539", "species_76577" ], "modifiers": [ [ "species_10455435", "catalyst" ] ], "additional_components": [ "species_29926", "P39205", "FBgn0000316" ] }, "reaction_10455403": { "compartment": "compartment_70101", "id": "reaction_10455403", "reactome": "R-DME-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10455400", "catalyst" ] ], "additional_components": [ "FBgn0002641" ] }, "reaction_10455450": { "compartment": "compartment_70101", "id": "reaction_10455450", "reactome": "R-DME-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356", "species_71284" ], "products": [ "species_111294", "species_947537", "species_947703", "species_174390" ], "modifiers": [ [ "species_10455447", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q8IQF1", "FBgn0263241" ] }, "reaction_10455426": { "compartment": "compartment_70101", "id": "reaction_10455426", "reactome": "R-DME-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455410", "species_111707" ], "products": [ "species_10455415", "species_29432" ], "modifiers": [ [ "species_10455423", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VLJ8", "FBgn0032054", "species_1562550", "Q9VLJ8", "FBgn0032054", "Q9VKD3", "FBgn0032393" ] }, "reaction_10497008": { "compartment": "compartment_12045", "id": "reaction_10497008", "reactome": "R-DME-9026967", "name": "VKORC1 inhibitors binds VKORC1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435910", "species_9035082" ], "products": [ "species_10435913" ], "modifiers": [], "additional_components": [ "A1ZAJ5", "FBgn0053544", "A1ZAJ5", "FBgn0053544" ] }, "reaction_10486243": { "compartment": "compartment_17957", "id": "reaction_10486243", "reactome": "R-DME-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806362", "species_6806656" ], "modifiers": [ [ "species_10486240", "catalyst" ] ], "additional_components": [ "FBgn0028375" ] }, "reaction_10435915": { "compartment": "compartment_12045", "id": "reaction_10435915", "reactome": "R-DME-159790", "name": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_6806366" ], "products": [ "species_6806362" ], "modifiers": [ [ "species_10435910", "catalyst" ], [ "species_10435913", "inhibitor" ] ], "additional_components": [ "A1ZAJ5", "FBgn0053544", "A1ZAJ5", "FBgn0053544" ] }, "reaction_10486235": { "compartment": "compartment_17957", "id": "reaction_10486235", "reactome": "R-DME-6806647", "name": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_6806366" ], "products": [ "species_6806362" ], "modifiers": [ [ "species_10486232", "catalyst" ] ], "additional_components": [ "FBgn0053544" ] }, "reaction_10455791": { "compartment": "compartment_70101", "id": "reaction_10455791", "reactome": "R-DME-975635", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_975643" ], "products": [ "species_975622" ], "modifiers": [ [ "species_10455788", "catalyst" ] ], "additional_components": [ "Q9VFS2", "FBgn0002937", "species_111793" ] }, "reaction_10465678": { "compartment": "compartment_70101", "id": "reaction_10465678", "reactome": "R-DME-2404142", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431845", "species_2473616" ], "products": [ "species_10465676" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_2473604", "Q8INK3", "FBgn0037913" ] }, "reaction_10455773": { "compartment": "compartment_984", "id": "reaction_10455773", "reactome": "R-DME-975594", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_975591" ], "products": [ "species_975590", "species_426576" ], "modifiers": [ [ "species_10455770", "catalyst" ] ], "additional_components": [ "FBgn0036939" ] }, "reaction_10465674": { "compartment": "compartment_70101", "id": "reaction_10465674", "reactome": "R-DME-2399913", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_10455775" ], "products": [ "species_10455779" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_975622" ] }, "reaction_10467095": { "compartment": "compartment_70101", "id": "reaction_10467095", "reactome": "R-DME-2855259", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473610", "species_10431845" ], "products": [ "species_10465680" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_2473604" ] }, "reaction_10455781": { "compartment": "compartment_70101", "id": "reaction_10455781", "reactome": "R-DME-975633", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975590", "species_10455775" ], "products": [ "species_10455777" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_2473604" ] }, "reaction_10467093": { "compartment": "compartment_70101", "id": "reaction_10467093", "reactome": "R-DME-2855252", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455779", "species_70106", "species_29364" ], "products": [ "species_10455777", "species_29366" ], "modifiers": [ [ "species_10467090", "catalyst" ] ], "additional_components": [ "Q8INK3", "FBgn0037913", "species_975622", "Q8INK3", "FBgn0037913", "species_2473604", "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10470451": { "compartment": "compartment_5460", "id": "reaction_10470451", "reactome": "R-DME-5164399", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_5164389" ], "products": [ "species_5164390", "species_5164383" ], "modifiers": [ [ "species_10470448", "catalyst" ] ], "additional_components": [ "Q9VFS2", "FBgn0002937", "species_111793" ] }, "reaction_10465682": { "compartment": "compartment_70101", "id": "reaction_10465682", "reactome": "R-DME-2404144", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465680" ], "products": [ "species_10431845", "species_2473616" ], "modifiers": [], "additional_components": [ "Q8INK3", "FBgn0037913", "species_2473604", "FBgn0037913" ] }, "reaction_10491072": { "compartment": "compartment_70101", "id": "reaction_10491072", "reactome": "R-DME-8874705", "name": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491068" ], "products": [ "species_10491070" ], "modifiers": [], "additional_components": [ "species_8874708", "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783", "species_8874708", "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783" ] }, "reaction_10491074": { "compartment": "compartment_70101", "id": "reaction_10491074", "reactome": "R-DME-8874718", "name": "TTPA binds alpha-TOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491066", "species_8874708" ], "products": [ "species_10491068" ], "modifiers": [], "additional_components": [ "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783", "species_8874708", "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783" ] }, "reaction_10459358": { "compartment": "compartment_70101", "id": "reaction_10459358", "reactome": "R-DME-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10459355", "catalyst" ] ], "additional_components": [ "species_1562550", "P48611", "FBgn0003141" ] }, "reaction_10459534": { "compartment": "compartment_70101", "id": "reaction_10459534", "reactome": "R-DME-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474179", "species_29364" ], "products": [ "species_29870", "species_29366" ], "modifiers": [ [ "species_10459531", "catalyst" ] ], "additional_components": [ "O76752", "FBgn0014032" ] }, "reaction_10459879": { "compartment": "compartment_70101", "id": "reaction_10459879", "reactome": "R-DME-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441857", "species_1497857" ], "products": [ "species_29870", "species_10459877" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "species_1497857", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10459347": { "compartment": "compartment_70101", "id": "reaction_10459347", "reactome": "R-DME-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10459344", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "P48596", "FBgn0003162" ] }, "reaction_10459555": { "compartment": "compartment_70101", "id": "reaction_10459555", "reactome": "R-DME-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459538", "species_113592" ], "products": [ "species_29370", "species_10459355" ], "modifiers": [ [ "species_10459552", "catalyst" ] ], "additional_components": [ "P48611", "FBgn0003141", "species_1562550", "P48611", "FBgn0003141", "Q9VL34", "FBgn0032187", "Q03043", "FBgn0000721", "Q03042", "FBgn0000442" ] }, "reaction_10459890": { "compartment": "compartment_70101", "id": "reaction_10459890", "reactome": "R-DME-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1497811", "species_29364" ], "products": [ "species_1497857", "species_29366" ], "modifiers": [ [ "species_10459531", "catalyst" ] ], "additional_components": [ "O76752", "FBgn0014032" ] }, "reaction_10459888": { "compartment": "compartment_70101", "id": "reaction_10459888", "reactome": "R-DME-1497853", "name": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10459886" ], "products": [ "species_29370", "species_10459531" ], "modifiers": [ [ "species_10459552", "catalyst" ] ], "additional_components": [ "O76752", "FBgn0014032", "O76752", "FBgn0014032", "Q9VL34", "FBgn0032187", "Q03043", "FBgn0000721", "Q03042", "FBgn0000442" ] }, "reaction_10446462": { "compartment": "compartment_17951", "id": "reaction_10446462", "reactome": "R-DME-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389548", "species_389556" ], "products": [ "species_193465", "species_389536", "species_389537", "species_113602" ], "modifiers": [ [ "species_10446459", "catalyst" ] ], "additional_components": [ "B7Z0E0", "FBgn0001248" ] }, "reaction_10465151": { "compartment": "compartment_5460", "id": "reaction_10465151", "reactome": "R-DME-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162209" ], "products": [ "species_2162252", "species_113529", "species_2162215" ], "modifiers": [ [ "species_10465137", "catalyst" ] ], "additional_components": [ "FBgn0032922" ] }, "reaction_10465148": { "compartment": "compartment_70616", "id": "reaction_10465148", "reactome": "R-DME-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10465145", "catalyst" ] ], "additional_components": [ "FBgn0037574" ] }, "reaction_10465174": { "compartment": "compartment_5460", "id": "reaction_10465174", "reactome": "R-DME-2162253", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162257", "species_2162256" ], "products": [ "species_159450", "species_2162214" ], "modifiers": [ [ "species_10465171", "catalyst" ] ], "additional_components": [ "Q9V9Z3", "FBgn0051005", "species_29926", "Q9VP87", "FBgn0037044" ] }, "reaction_10465140": { "compartment": "compartment_5460", "id": "reaction_10465140", "reactome": "R-DME-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162212" ], "products": [ "species_2162252", "species_113529", "species_2162198" ], "modifiers": [ [ "species_10465137", "catalyst" ] ], "additional_components": [ "FBgn0032922" ] }, "reaction_216133": { "compartment": "compartment_70101", "id": "reaction_216133", "reactome": "R-DME-216133", "name": "Dissociation of CI from COS", "reversible": "false", "notes": "Coastal2 (COS) phosphorylated on Ser572 has reduced affinity for Cubitus Interruptus (CI). This may contribute to partial dissociation of CI from COS complexes.", "reactants": [ "species_206734" ], "products": [ "species_206046", "species_206634" ], "modifiers": [], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P91682", "phospho-smo" ] }, "reaction_209220": { "compartment": "compartment_70101", "id": "reaction_209220", "reactome": "R-DME-209220", "name": "Liberation of CI from SU(FU) repression", "reversible": "false", "notes": "Cubitus Interruptus (CI) that is spared from proteolysis is liberated from the repressive effects of its direct binding partner, Supressor of Fused (SU(FU)), by Fused (FU) Ser/Thr kinase activity. FU is believed to phosphorylate SU(FU) but it is not known if this relieves repression.", "reactants": [ "species_113592", "species_206634", "species_206802" ], "products": [ "species_205950", "species_206046", "species_29370", "species_206634" ], "modifiers": [ [ "species_205872", "catalyst" ] ], "additional_components": [ "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P91682", "phospho-smo", "Q27279", "Phospho SU(FU)", "P19538", "ci", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P91682", "phospho-smo" ] }, "reaction_209163": { "compartment": "compartment_13231", "id": "reaction_209163", "reactome": "R-DME-209163", "name": "CI transports from the cytosol to the nucleus", "reversible": "false", "notes": "Cubitus Interruptus (CI) access to the nucleus increases in response to Hedgehog signalling, most likely due to reduced cytoplasmic tethering by both Coastal2 (COS) and Suppressor of Fused (SU(FU)) complexes. However, the vast majority of CI is cytoplasmic.", "reactants": [ "species_206046" ], "products": [ "species_205911" ], "modifiers": [], "additional_components": [] }, "reaction_209215": { "compartment": "compartment_7660", "id": "reaction_209215", "reactome": "R-DME-209215", "name": "CI activates transcription", "reversible": "false", "notes": "Cubitus Interruptus (CI) activates transcription of ptc and several tissue-specific target genes that include direct CI binding sites in their regulatory sequences. CREB binding protein, CBP (NEJ) co-activator contributes to transcriptional activation.", "reactants": [ "species_205911" ], "products": [ "species_205911" ], "modifiers": [], "additional_components": [] }, "reaction_209178": { "compartment": "compartment_876", "id": "reaction_209178", "reactome": "R-DME-209178", "name": "N-HH binds to PTC receptor complex", "reversible": "false", "notes": "N-HH bound to Dally-like protein (DLP) is presented to Patched (PTC) receptor and Induced Hedgehog/Brother of Induced Hedgehog (IHOG/BOI) co-receptor to form a ternary complex at the plasma membrane. N-HH binds directly to PTC. Binding is enhanced by the putative co-receptor, IHOG/BOI, which is a type I transmembrane protein that can bind N-HH directly in the presence of Heparin. Signal transduction is also enhanced by DLP, implying that heparan sulphate proteoglycan (HSPG)-associated N-HH may be the most potent form of Hedgehog. Binding of N-HH to PTC leads to PTC internalisation and lysosomal degradation, resulting in a reduction of extracellular N-HH levels and a relief of repression of Smoothened (SMO) by PTC, which depends on the opposing actions of free PTC and N-HH bound PTC.", "reactants": [ "species_216284", "species_206021", "species_216135" ], "products": [ "species_216226" ], "modifiers": [], "additional_components": [ "Q02936", "hh", "Q9GPL5", "DLP", "Q9VM64", "ihog", "Q9W4Y6", "BOI", "Q02936", "hh", "Q9VM64", "ihog", "Q9W4Y6", "BOI", "P18502", "ptc", "Q9GPL5", "DLP" ] }, "reaction_216222": { "compartment": "compartment_70101", "id": "reaction_216222", "reactome": "R-DME-216222", "name": "COS binds to SMO", "reversible": "false", "notes": "SMO:COS:FU:CI complexes are present prior to Hedgehog signalling owing to direct binding of Smoothened (SMO) to both Coastal2 (COS) and the Ser/Thr kinase Fused (FU).", "reactants": [ "species_216188", "species_206086" ], "products": [ "species_216146" ], "modifiers": [], "additional_components": [ "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_209253": { "compartment": "compartment_70101", "id": "reaction_209253", "reactome": "R-DME-209253", "name": "Autophosphorylated FU phosphorylates COS", "reversible": "false", "notes": "The Ser/Thr protein kinase, Fused (FU), is capable of autophosphorylation and is proposed to be activated by phosphorylation on at least Thr158 and probably on other residues too. Costal2 (COS), bound to the phosphorylated transmembrane receptor Smoothened (SMO), is itself phosphorylated by FU at Ser572 and Ser931. Both FU and COS promote phosphorylation of SMO and its accumulation at the plasma membrane resulting in a positive feedback loop.", "reactants": [ "species_216158", "species_113592" ], "products": [ "species_206734", "species_29370" ], "modifiers": [ [ "species_205872", "catalyst" ] ], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_216202": { "compartment": "compartment_876", "id": "reaction_216202", "reactome": "R-DME-216202", "name": "Phosphorylated SMO changes conformation and is activated", "reversible": "false", "notes": "The Smoothened (SMO) large terminal cytoplasmic domain changes conformation in response to phosphorylation and becomes active. The localisation of SMO and its partners shifts from internal vesicles towards the plasma membrane. SMO stability increases results in the SMO:COS:FU:CI complexes at the plasma membrane becoming more abundant.Activation of SMO leads to reduced association of the Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase 1 alpha (CKIalpha), and Casein kinase I epsilon (DCO) with Costal2 (COS). This leads to a reduced phosphorylation of Cubitus Interruptus (CI) and inhibition of CI proteolysis and processing. This increases full-length CI protein levels.", "reactants": [ "species_206727" ], "products": [ "species_216158" ], "modifiers": [], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_209168": { "compartment": "compartment_70101", "id": "reaction_209168", "reactome": "R-DME-209168", "name": "Phosphorylation of SMO by CKIalpha", "reversible": "false", "notes": "Priming phosphorylation of the transmembrane protein Smoothened (SMO) leads to additional phosphorylation by Casein kinase I alpha (CKIalpha) at Ser670, Ser673, Ser690, Ser693, Ser743, and Ser746. Even though SMO has been shown to be explicitly phosphorylated by CKIalpha, phosphorylation of these residues by other CK1 isoforms cannot be ruled out. In addition, other residues are probably phosphorylated by unidentified kinases.", "reactants": [ "species_216105", "species_113592" ], "products": [ "species_29370", "species_206727" ], "modifiers": [ [ "species_206666", "catalyst" ] ], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209341": { "compartment": "compartment_70101", "id": "reaction_209341", "reactome": "R-DME-209341", "name": "Phosphorylation of SMO by PKA-C1", "reversible": "false", "notes": "The Ser/Thr kinase, Protein kinase A (PKA-C1) carries out priming phosphorylation of the transmembrane protein Smoothened (SMO) at Ser667, Ser687, and Ser740.", "reactants": [ "species_113592", "species_216146" ], "products": [ "species_29370", "species_216105" ], "modifiers": [ [ "species_206865", "catalyst" ] ], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "Q24170", "Phospho KSR", "P11346", "Raf", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "Q7KNQ9", "cnk", "Q8ML92", "AVE", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10458816": { "compartment": "compartment_876", "id": "reaction_10458816", "reactome": "R-DME-1296127", "name": "Activation of voltage gated Potassium channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458813", "catalyst" ] ], "additional_components": [ "M9PHI0", "FBgn0263220", "P17972", "FBgn0003386", "A8DYR5", "FBgn0085395", "Q7JPB9", "FBgn0003353", "P17970", "FBgn0262593", "Q02280", "FBgn0000535", "A1ZB14", "FBgn0011589", "P17971", "FBgn0005564", "A1Z856", "FBgn0033494", "P08510", "FBgn0003380" ] }, "reaction_10451102": { "compartment": "compartment_7660", "id": "reaction_10451102", "reactome": "R-DME-450550", "name": "PKCalpha phosphorylates HuR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10429721" ], "products": [ "species_113582", "species_10450960" ], "modifiers": [ [ "species_10451099", "catalyst" ] ], "additional_components": [ "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "FBgn0003091" ] }, "reaction_10451085": { "compartment": "compartment_7660", "id": "reaction_10451085", "reactome": "R-DME-450494", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429721", "species_450613" ], "products": [ "species_10450946" ], "modifiers": [], "additional_components": [ "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400" ] }, "reaction_10451097": { "compartment": "compartment_7660", "id": "reaction_10451097", "reactome": "R-DME-450533", "name": "PKCdelta phosphorylates HuR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10429721" ], "products": [ "species_113582", "species_10450973" ], "modifiers": [ [ "species_10451094", "catalyst" ] ], "additional_components": [ "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "FBgn0259680" ] }, "reaction_10450981": { "compartment": "compartment_7660", "id": "reaction_10450981", "reactome": "R-DME-450387", "name": "HuR binds the CRM1 nuclear export machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450944", "species_10450977", "species_10450932", "species_10450937", "species_10450939", "species_10437629" ], "products": [ "species_10450979" ], "modifiers": [], "additional_components": [ "FBgn0014879", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "FBgn0033483", "FBgn0034282", "FBgn0010660", "FBgn0020497", "Q9TVM2", "FBgn0020497", "Q9W1X4", "FBgn0010660", "Q9V895", "FBgn0034282", "Q8MUJ1", "FBgn0033483", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "P53997", "FBgn0014879" ] }, "reaction_10453156": { "compartment": "compartment_7660", "id": "reaction_10453156", "reactome": "R-DME-517705", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450973", "species_517622" ], "products": [ "species_10450975" ], "modifiers": [], "additional_components": [ "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263" ] }, "reaction_10453154": { "compartment": "compartment_7660", "id": "reaction_10453154", "reactome": "R-DME-517674", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450960", "species_450605" ], "products": [ "species_10450962" ], "modifiers": [], "additional_components": [ "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263" ] }, "reaction_10451200": { "compartment": "compartment_7660", "id": "reaction_10451200", "reactome": "R-DME-450595", "name": "HuR:mRNA complex translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450979" ], "products": [ "species_10451164", "species_10451198" ], "modifiers": [], "additional_components": [ "Q9TVM2", "FBgn0020497", "Q9W1X4", "FBgn0010660", "Q9V895", "FBgn0034282", "Q8MUJ1", "FBgn0033483", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "P53997", "FBgn0014879", "FBgn0033483", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263" ] }, "reaction_10451005": { "compartment": "compartment_70101", "id": "reaction_10451005", "reactome": "R-DME-450400", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451001", "species_10450986", "species_450597" ], "products": [ "species_10451003" ], "modifiers": [], "additional_components": [ "FBgn0011837", "FBgn0024921", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837" ] }, "reaction_10451052": { "compartment": "compartment_70101", "id": "reaction_10451052", "reactome": "R-DME-450463", "name": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451003" ], "products": [ "species_10450995", "species_29370" ], "modifiers": [ [ "species_10439416", "catalyst" ] ], "additional_components": [ "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "FBgn0013987" ] }, "reaction_10451031": { "compartment": "compartment_70101", "id": "reaction_10451031", "reactome": "R-DME-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448993", "species_10451027", "species_10449000", "species_10451003", "species_10449102" ], "products": [ "species_10451029" ], "modifiers": [], "additional_components": [ "FBgn0034921", "FBgn0020261", "FBgn0036534", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "Q5U127", "FBgn0036534", "E1JJR3", "FBgn0020261", "Q9W1H5", "FBgn0034921" ] }, "reaction_10450999": { "compartment": "compartment_70101", "id": "reaction_10450999", "reactome": "R-DME-450394", "name": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450995", "species_10432008" ], "products": [ "species_10450997" ], "modifiers": [], "additional_components": [ "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "P29310", "14-3-3zeta", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837" ] }, "reaction_10453023": { "compartment": "compartment_70101", "id": "reaction_10453023", "reactome": "R-DME-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451075", "species_10432008" ], "products": [ "species_10453021" ], "modifiers": [], "additional_components": [ "P47980", "FBgn0011837", "P29310", "14-3-3zeta", "P47980", "FBgn0011837" ] }, "reaction_10451083": { "compartment": "compartment_70101", "id": "reaction_10451083", "reactome": "R-DME-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451069" ], "products": [ "species_10451011", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "P47980", "FBgn0011837", "P47980", "FBgn0011837" ] }, "reaction_10451081": { "compartment": "compartment_70101", "id": "reaction_10451081", "reactome": "R-DME-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448993", "species_10451027", "species_10449000", "species_10451069", "species_10449102" ], "products": [ "species_10451079" ], "modifiers": [], "additional_components": [ "FBgn0034921", "FBgn0020261", "FBgn0036534", "P47980", "FBgn0011837", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "P47980", "FBgn0011837", "Q5U127", "FBgn0036534", "E1JJR3", "FBgn0020261", "Q9W1H5", "FBgn0034921" ] }, "reaction_10451015": { "compartment": "compartment_70101", "id": "reaction_10451015", "reactome": "R-DME-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451011", "species_10432008" ], "products": [ "species_10451013" ], "modifiers": [], "additional_components": [ "P47980", "FBgn0011837", "P29310", "14-3-3zeta", "P47980", "FBgn0011837" ] }, "reaction_10451077": { "compartment": "compartment_70101", "id": "reaction_10451077", "reactome": "R-DME-450474", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451069" ], "products": [ "species_10451075", "species_29370" ], "modifiers": [ [ "species_10439416", "catalyst" ] ], "additional_components": [ "P47980", "FBgn0011837", "P47980", "FBgn0011837", "FBgn0013987" ] }, "reaction_10451092": { "compartment": "compartment_70101", "id": "reaction_10451092", "reactome": "R-DME-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10451067" ], "products": [ "species_10451069" ], "modifiers": [], "additional_components": [ "FBgn0011837", "P47980", "FBgn0011837" ] }, "reaction_10451049": { "compartment": "compartment_70101", "id": "reaction_10451049", "reactome": "R-DME-450434", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451043", "species_450444" ], "products": [ "species_10451047" ], "modifiers": [], "additional_components": [ "Q08473", "FBgn0263396", "Q08473", "FBgn0263396" ] }, "reaction_10451065": { "compartment": "compartment_70101", "id": "reaction_10451065", "reactome": "R-DME-450466", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451063" ], "products": [], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q08473", "FBgn0263396", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10451160": { "compartment": "compartment_70101", "id": "reaction_10451160", "reactome": "R-DME-450580", "name": "AUF1 (hnRNP D0) is ubiquitinylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451156", "species_10426987" ], "products": [ "species_10451063" ], "modifiers": [], "additional_components": [ "P21187", "FBgn0265297", "P11147", "FBgn0266599", "Q08473", "FBgn0263396", "Q8IQW5", "FBgn0031037", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08473", "FBgn0263396" ] }, "reaction_10451158": { "compartment": "compartment_70101", "id": "reaction_10451158", "reactome": "R-DME-450551", "name": "AUF1 binds translation and heat shock proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430497", "species_10451154", "species_10451107", "species_10451047", "species_10447995", "species_10435551" ], "products": [ "species_10451156" ], "modifiers": [], "additional_components": [ "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "FBgn0031037", "Q08473", "FBgn0263396", "FBgn0266599", "FBgn0265297", "P21187", "FBgn0265297", "P11147", "FBgn0266599", "Q08473", "FBgn0263396", "Q8IQW5", "FBgn0031037", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10451162": { "compartment": "compartment_70101", "id": "reaction_10451162", "reactome": "R-DME-450592", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450386", "species_10451020" ], "products": [ "species_10451022" ], "modifiers": [], "additional_components": [ "FBgn0014870", "A1ZAK8", "FBgn0014870" ] }, "reaction_10451208": { "compartment": "compartment_70101", "id": "reaction_10451208", "reactome": "R-DME-450620", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451088", "species_10451202" ], "products": [ "species_10451206" ], "modifiers": [], "additional_components": [ "FBgn0014870", "A1ZAK8", "FBgn0014870", "P29310", "14-3-3zeta" ] }, "reaction_10451090": { "compartment": "compartment_70101", "id": "reaction_10451090", "reactome": "R-DME-450499", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451020" ], "products": [ "species_10451088", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0014870", "FBgn0014870" ] }, "reaction_10492435": { "compartment": "compartment_7660", "id": "reaction_10492435", "reactome": "R-DME-8938853", "name": "CDK6 binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492431", "species_10492429" ], "products": [ "species_10492433" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0016131", "Q7K306", "FBgn0016131", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10492437": { "compartment": "compartment_7660", "id": "reaction_10492437", "reactome": "R-DME-8938867", "name": "CCND3,(CCND1,CCND2) binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457981", "species_10489792" ], "products": [ "species_10489796" ], "modifiers": [], "additional_components": [ "FBgn0010315", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10489798": { "compartment": "compartment_7660", "id": "reaction_10489798", "reactome": "R-DME-8865320", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489782", "species_10489792" ], "products": [ "species_10489794" ], "modifiers": [ [ "species_10489796", "inhibitor" ] ], "additional_components": [ "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10466198": { "compartment": "compartment_876", "id": "reaction_10466198", "reactome": "R-DME-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10466195", "catalyst" ] ], "additional_components": [ "Q03720", "FBgn0003429" ] }, "reaction_10449198": { "compartment": "compartment_876", "id": "reaction_10449198", "reactome": "R-DME-432010", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10449195", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872" ] }, "reaction_10449388": { "compartment": "compartment_70101", "id": "reaction_10449388", "reactome": "R-DME-432232", "name": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10449372" ], "products": [ "species_29370", "species_10449386" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "D3DMU9", "FBgn0033635", "D3DMU9", "FBgn0033635", "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10449412": { "compartment": "compartment_876", "id": "reaction_10449412", "reactome": "R-DME-432237", "name": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449386" ], "products": [ "species_10449231" ], "modifiers": [ [ "species_10449409", "catalyst" ] ], "additional_components": [ "D3DMU9", "FBgn0033635", "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884", "O18335", "FBgn0015790", "species_29438", "Q9VWS3", "FBgn0027335", "A1Z6Z8", "FBgn0261397" ] }, "reaction_10449251": { "compartment": "compartment_876", "id": "reaction_10449251", "reactome": "R-DME-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10449248", "catalyst" ] ], "additional_components": [ "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "D3DMU9", "FBgn0033635" ] }, "reaction_10449234": { "compartment": "compartment_876", "id": "reaction_10449234", "reactome": "R-DME-432065", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10449231", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884" ] }, "reaction_10449200": { "compartment": "compartment_876", "id": "reaction_10449200", "reactome": "R-DME-432054", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10449195", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872" ] }, "reaction_10432557": { "compartment": "compartment_70101", "id": "reaction_10432557", "reactome": "R-DME-75886", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76114" ], "products": [ "species_76194", "species_76112" ], "modifiers": [ [ "species_10432552", "catalyst" ] ], "additional_components": [ "FBgn0027579" ] }, "reaction_10432635": { "compartment": "compartment_70101", "id": "reaction_10432635", "reactome": "R-DME-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10432632", "catalyst" ] ], "additional_components": [ "Q960U8", "FBgn0004797" ] }, "reaction_10484777": { "compartment": "compartment_12045", "id": "reaction_10484777", "reactome": "R-DME-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10484774", "catalyst" ] ], "additional_components": [ "Q7JYK2", "FBgn0033214", "Q7K1C2", "FBgn0033215", "A1Z739", "FBgn0033216" ] }, "reaction_10453385": { "compartment": "compartment_70101", "id": "reaction_10453385", "reactome": "R-DME-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10453382", "catalyst" ] ], "additional_components": [ "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216", "Q7K1C2", "FBgn0033215" ] }, "reaction_10432581": { "compartment": "compartment_70101", "id": "reaction_10432581", "reactome": "R-DME-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76116" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10432578", "catalyst" ] ], "additional_components": [ "Q7JY99", "FBgn0033673" ] }, "reaction_10432625": { "compartment": "compartment_70101", "id": "reaction_10432625", "reactome": "R-DME-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76108", "species_29356" ], "products": [ "species_29372", "species_76103" ], "modifiers": [ [ "species_10432618", "catalyst" ] ], "additional_components": [ "FBgn0263593" ] }, "reaction_10487894": { "compartment": "compartment_70101", "id": "reaction_10487894", "reactome": "R-DME-8848339", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_549167" ], "products": [ "species_8876730", "species_76103" ], "modifiers": [ [ "species_10487891", "catalyst" ] ], "additional_components": [ "Q9VXY8", "FBgn0030607", "E1JI03", "FBgn0036449" ] }, "reaction_10471590": { "compartment": "compartment_70101", "id": "reaction_10471590", "reactome": "R-DME-5334794", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876730", "species_10471582" ], "products": [ "species_10471588" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_8954142" ] }, "reaction_10439494": { "compartment": "compartment_5460", "id": "reaction_10439494", "reactome": "R-DME-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_31649", "species_188451" ], "modifiers": [ [ "species_10439491", "catalyst" ] ], "additional_components": [ "FBgn0022160" ] }, "reaction_209331": { "compartment": "compartment_70101", "id": "reaction_209331", "reactome": "R-DME-209331", "name": "Formation of the 'scaffold complex'", "reversible": "false", "notes": "The kinesin-related protein, Costal2 (COS), forms a microtubule-associated 'scaffold complex' with Cubitus Interruptus (CI) and the Ser/Thr protein kinase Fused (FU). CI also associates directly with the Supressor of Fused (SU(FU)) protein in a separate complex. Complexes containing CI, COS, FU and SU(FU) are detectable but rare. The Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase I alpha (CKIalpha), and Casein kinase I epsilon (DCO) all bind to the scaffold protein COS.", "reactants": [ "species_206046", "species_205832", "species_205931", "species_205716", "species_205872", "species_205729", "species_206210" ], "products": [ "species_206721" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_216136": { "compartment": "compartment_70101", "id": "reaction_216136", "reactome": "R-DME-216136", "name": "Formation of the CI:SU(FU) complex", "reversible": "false", "notes": "Cubitus Interruptus (CI) forms a separate complex with the Supressor of Fused (SU(FU)) protein.", "reactants": [ "species_206046", "species_206064" ], "products": [ "species_206802" ], "modifiers": [], "additional_components": [ "Q27279", "Phospho SU(FU)", "P19538", "ci" ] }, "reaction_209252": { "compartment": "compartment_7660", "id": "reaction_209252", "reactome": "R-DME-209252", "name": "CI75 inhibits transcription", "reversible": "false", "notes": "Upon arrival in the nucleus, truncated Cubitus Interruptus (CI75) represses transcription. Sensitive target genes include hh and dpp, but not ptc and repression depends on direct DNA-binding sites for CI75.", "reactants": [ "species_205741" ], "products": [ "species_205741" ], "modifiers": [], "additional_components": [] }, "reaction_209370": { "compartment": "compartment_13231", "id": "reaction_209370", "reactome": "R-DME-209370", "name": "CI75 transports from the cytosol to the nucleus", "reversible": "false", "notes": "Truncated Cubitus Interruptus (CI75) translocates from the cytosol to the nucleus.", "reactants": [ "species_206171" ], "products": [ "species_205741" ], "modifiers": [], "additional_components": [] }, "reaction_209313": { "compartment": "compartment_70101", "id": "reaction_209313", "reactome": "R-DME-209313", "name": "Autocleavage of HH", "reversible": "false", "notes": "The autoprocessing event results in cleavage of Hedgehog (HH) between Gly207 and Cys208, coupled to the covalent addition of cholesterol to Gly207 via an ester linkage to form N-HH.", "reactants": [ "species_176478", "species_205973" ], "products": [ "species_206216", "species_206215" ], "modifiers": [], "additional_components": [] }, "reaction_209271": { "compartment": "compartment_876", "id": "reaction_209271", "reactome": "R-DME-209271", "name": "N-HH moves from the cytosol to the extracellular region", "reversible": "false", "notes": "With the help of the transmembrane protein Dispatched (DISP), N-HH is secreted from the cytosol to the extracellular region.", "reactants": [ "species_206055", "species_206215" ], "products": [ "species_206055", "species_205888" ], "modifiers": [], "additional_components": [] }, "reaction_209272": { "compartment": "compartment_984", "id": "reaction_209272", "reactome": "R-DME-209272", "name": "N-HH binds to the transmembrane HSPG proteins", "reversible": "false", "notes": "N-HH movement between cells is facilitated by the glypicans aka heparan sulphate proteoglycan proteins (HSPGs), Dally (DALLY) and Dally-like protein (DLP) which require heparan sulphate modification by the Exostosin (EXT) family proteins tout-velu (TTV), brother of tout-velu (BOTV) and sister of tout-velu (EXT2) for this purpose. N-HH can form multimers, associated with enhanced movement of vertebrate Sonic Hedgehog, and can associate with lipophorin-containing lipophorin particles which appear to enhance N-HH movement. The protein Shifted (SHF) also facilitates HH movement.", "reactants": [ "species_205888", "species_206547" ], "products": [ "species_207018" ], "modifiers": [], "additional_components": [ "Q24114", "dally", "Q9GPL5", "DLP", "Q24114", "dally", "Q9GPL5", "DLP", "Q02936", "hh" ] }, "reaction_209357": { "compartment": "compartment_70101", "id": "reaction_209357", "reactome": "R-DME-209357", "name": "N-HH is palmitoylated by RASP", "reversible": "false", "notes": "After removal of an N-terminal signal sequence, RASP, a protein-cysteine N-palmitoyltransferase, palmitoylates the new N-terminus (CGPGR..) via a thiol intermediate that resolves into a stable amide linkage. Palmitoylation efficiency is increased by prior addition of cholesterol at the C-terminus.", "reactants": [ "species_76168", "species_206215" ], "products": [ "species_206215" ], "modifiers": [ [ "species_205927", "catalyst" ] ], "additional_components": [] }, "reaction_209185": { "compartment": "compartment_876", "id": "reaction_209185", "reactome": "R-DME-209185", "name": "Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for monomeric peptidoglycans (PGN). However, when monomeric PGN binds to PGRP-LCx receptor primarily through its elongated stem peptide, the unique disaccharide GlcNAc-MurNAc(anhydro) residues of the ligand are then presented by PGRP-LCx receptor in such a way as to make favourable interactions with the PGRP-LCa receptor ectodomain. The receptors are now in close proximity and can heterodimerise.", "reactants": [ "species_205720", "species_206681" ], "products": [ "species_206990" ], "modifiers": [], "additional_components": [ "Q9GNK5-2", "PGRP-LCx", "species_214401", "species_214401", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_209158": { "compartment": "compartment_876", "id": "reaction_209158", "reactome": "R-DME-209158", "name": "Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane", "reversible": "false", "notes": "The binding of polymeric peptidoglycan (PGN) to PGRP-LCx receptor results in adjacent PGRP-LCx receptors additionally binding to PGN. This brings the receptors into close enough proximity for them to multimerise.", "reactants": [ "species_207039", "species_205794" ], "products": [ "species_354316" ], "modifiers": [], "additional_components": [ "Q9GNK5-2", "PGRP-LCx", "species_214401", "CHEBI:28881", "species_1678743", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx" ] }, "reaction_214395": { "compartment": "compartment_70101", "id": "reaction_214395", "reactome": "R-DME-214395", "name": "Monomeric PGN bound PGRP-LE oligomerises in the cytosol", "reversible": "false", "notes": "The binding of monomeric peptidoglycans (PGN) to PGRP-LE receptor results in adjacent PGRP-LE receptors binding to the complex and forming a PGRP-LE oligomer.", "reactants": [ "species_214396" ], "products": [ "species_354246" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "species_214401", "Q9VXN9", "PGRP-LE" ] }, "reaction_10430841": { "compartment": "compartment_70101", "id": "reaction_10430841", "reactome": "R-DME-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430368", "species_10430435", "species_10430440" ], "products": [ "species_10430839" ], "modifiers": [], "additional_components": [ "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "FBgn0026250", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136" ] }, "reaction_10430837": { "compartment": "compartment_70101", "id": "reaction_10430837", "reactome": "R-DME-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430818", "species_10430440" ], "products": [ "species_10430816", "species_10430368", "species_10430440" ], "modifiers": [], "additional_components": [ "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "FBgn0026250", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "FBgn0026250" ] }, "reaction_10430527": { "compartment": "compartment_70101", "id": "reaction_10430527", "reactome": "R-DME-72622", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430525" ], "products": [ "species_10430485", "species_10430523" ], "modifiers": [], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709" ] }, "reaction_10430529": { "compartment": "compartment_70101", "id": "reaction_10430529", "reactome": "R-DME-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430497", "species_10430485", "species_10430474" ], "products": [ "species_10430499" ], "modifiers": [], "additional_components": [ "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q02748", "FBgn0001942", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10430568": { "compartment": "compartment_70101", "id": "reaction_10430568", "reactome": "R-DME-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430564", "species_10430517" ], "products": [ "species_10430566" ], "modifiers": [], "additional_components": [ "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29420", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "species_29420" ] }, "reaction_10430848": { "compartment": "compartment_70101", "id": "reaction_10430848", "reactome": "R-DME-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10430566" ], "products": [ "species_29420", "species_10430564", "species_10430459" ], "modifiers": [ [ "species_10430564", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "species_29420", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029" ] }, "reaction_10430835": { "compartment": "compartment_70101", "id": "reaction_10430835", "reactome": "R-DME-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430816", "species_10430515", "species_10430825" ], "products": [ "species_10430827" ], "modifiers": [], "additional_components": [ "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9VZP5", "FBgn0026259", "species_29438", "Q9VZP5", "FBgn0026259", "species_29438", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897" ] }, "reaction_10430833": { "compartment": "compartment_70101", "id": "reaction_10430833", "reactome": "R-DME-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430827" ], "products": [ "species_29372", "species_10430829", "species_10430831" ], "modifiers": [], "additional_components": [ "Q9VZP5", "FBgn0026259", "species_29438", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VZP5", "FBgn0026259", "species_29420", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897" ] }, "reaction_10435566": { "compartment": "compartment_70101", "id": "reaction_10435566", "reactome": "R-DME-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430816" ], "products": [ "species_10430608", "species_10435564" ], "modifiers": [], "additional_components": [ "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "FBgn0037351", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897" ] }, "reaction_10435562": { "compartment": "compartment_70101", "id": "reaction_10435562", "reactome": "R-DME-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435553", "species_10435558" ], "products": [ "species_10435560" ], "modifiers": [], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P21187", "FBgn0265297", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0037351", "Q9VNE9", "FBgn0037351", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P21187", "FBgn0265297", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10447275": { "compartment": "compartment_7660", "id": "reaction_10447275", "reactome": "R-DME-400204", "name": "PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_422139", "species_10445291", "species_10440428" ], "products": [ "species_10447235" ], "modifiers": [], "additional_components": [ "FBgn0000568", "FBgn0003964", "P20153", "FBgn0003964", "P13055", "FBgn0000568" ] }, "reaction_10447273": { "compartment": "compartment_7660", "id": "reaction_10447273", "reactome": "R-DME-400183", "name": "PPARA:RXRA heterodimer recruits corepressors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447233", "species_10447235", "species_10447226", "species_10447231" ], "products": [ "species_10447237" ], "modifiers": [], "additional_components": [ "FBgn0263933", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "FBgn0025825", "FBgn0263933", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "P20153", "FBgn0003964", "P13055", "FBgn0000568" ] }, "reaction_10447271": { "compartment": "compartment_7660", "id": "reaction_10447271", "reactome": "R-DME-400143", "name": "Fatty acid ligands activate PPARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447237", "species_10447259", "species_10447263" ], "products": [ "species_10447269", "species_10447226", "species_10447261" ], "modifiers": [], "additional_components": [ "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "Q9VH48", "FBgn0037770", "M9MS40", "FBgn0261617", "Q9VEA4", "FBgn0266195", "M9ND53", "FBgn0041092", "Q9VP05", "FBgn0037109", "Q9VYG2", "FBgn0025463", "species_9661418", "Q8INK3", "FBgn0037913", "species_3632881", "CHEBI:28364", "CHEBI:27432", "CHEBI:17351", "species_422506", "Q95RJ9", "FBgn0263933", "Q9VH48", "FBgn0037770", "M9MS40", "FBgn0261617", "Q9VEA4", "FBgn0266195", "M9ND53", "FBgn0041092", "Q9VP05", "FBgn0037109", "Q9VYG2", "FBgn0025463", "species_9661418", "P20153", "FBgn0003964", "species_3632881", "CHEBI:28364", "CHEBI:27432", "CHEBI:17351", "species_422506", "P13055", "FBgn0000568", "FBgn0025825", "FBgn0037913" ] }, "reaction_10443214": { "compartment": "compartment_17960", "id": "reaction_10443214", "reactome": "R-DME-211904", "name": "CYP4F12 18-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_352318" ], "modifiers": [ [ "species_10443211", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS79", "FBgn0015033", "O46051", "FBgn0023541", "Q9VS78", "FBgn0035790", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q27589", "FBgn0011576", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "P33269", "FBgn0005670", "Q9VVN6", "FBgn0036778" ] }, "reaction_10443224": { "compartment": "compartment_17960", "id": "reaction_10443224", "reactome": "R-DME-211924", "name": "CYP4B1 12-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215075" ], "modifiers": [ [ "species_10443221", "catalyst" ] ], "additional_components": [ "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053" ] }, "reaction_10443253": { "compartment": "compartment_17960", "id": "reaction_10443253", "reactome": "R-DME-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10443250", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34157", "species_2142739", "CHEBI:34490", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10433058": { "compartment": "compartment_17960", "id": "reaction_10433058", "reactome": "R-DME-76466", "name": "CYP4A11 12-hydroxylates DDCX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_33549", "species_113601" ], "products": [ "species_113519", "species_113564", "species_42373" ], "modifiers": [ [ "species_10433055", "catalyst" ] ], "additional_components": [ "Q9VXY0", "FBgn0030615", "Q9V557", "FBgn0033395", "Q9VLZ7", "FBgn0031925", "O46051", "FBgn0023541", "Q9VVN6", "FBgn0036778", "Q9V4T5", "FBgn0015034", "Q9VL92", "FBgn0015035", "Q9VS79", "FBgn0015033", "Q9V4T3", "FBgn0033292", "Q9VGH1", "FBgn0003312", "Q9VS78", "FBgn0035790", "Q27606", "FBgn0014469", "Q9V7G5", "FBgn0034053", "Q9VMS9", "FBgn0031693", "Q27589", "FBgn0011576", "Q9W011", "FBgn0035344", "Q9V559", "FBgn0033397", "Q9VMS8", "FBgn0031694", "P33269", "FBgn0005670", "Q9VYQ7", "FBgn0030367", "Q9V558", "FBgn0015037", "Q9VMS7", "FBgn0031695", "O46054", "FBgn0015036" ] }, "reaction_10465651": { "compartment": "compartment_5460", "id": "reaction_10465651", "reactome": "R-DME-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113600", "species_10465647" ], "products": [ "species_113563", "species_10465645" ], "modifiers": [], "additional_components": [ "Q9V3T9", "FBgn0015582", "species_113596", "species_31649", "Q9V3T9", "FBgn0015582" ] }, "reaction_10465649": { "compartment": "compartment_5460", "id": "reaction_10465649", "reactome": "R-DME-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459056", "species_10465645" ], "products": [ "species_113529", "species_10459048", "species_10465647" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "P37193", "FBgn0011769", "Q8SZA8", "FBgn0035529", "species_31649", "Q9V3T9", "FBgn0015582", "Q8SZA8", "FBgn0035529", "CHEBI:33738", "P37193", "FBgn0011769", "Q9V3T9", "FBgn0015582", "species_113596" ] }, "reaction_10459064": { "compartment": "compartment_5460", "id": "reaction_10459064", "reactome": "R-DME-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10459062" ], "products": [ "species_10459032" ], "modifiers": [], "additional_components": [ "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "Q9W385", "FBgn0030092", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "species_111793", "Q9W385", "FBgn0030092" ] }, "reaction_10491819": { "compartment": "compartment_5460", "id": "reaction_10491819", "reactome": "R-DME-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491798", "species_10491810" ], "products": [ "species_10491796", "species_10491812" ], "modifiers": [ [ "species_10491817", "catalyst" ] ], "additional_components": [ "Q8SXQ5", "FBgn0030584", "CHEBI:33739", "Q9VC65", "FBgn0039205", "Q8T3X9", "FBgn0026666", "FBgn0030584", "Q9VC65", "FBgn0039205", "Q8T3X9", "FBgn0026666", "CHEBI:49883", "FBgn0263606" ] }, "reaction_10459059": { "compartment": "compartment_5460", "id": "reaction_10459059", "reactome": "R-DME-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10459048", "species_10459032" ], "products": [ "species_10459056", "species_10459050", "species_379697" ], "modifiers": [ [ "species_10459032", "catalyst" ], [ "species_10459048", "catalyst" ] ], "additional_components": [ "Q8SZA8", "FBgn0035529", "CHEBI:33738", "P37193", "FBgn0011769", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "species_111793", "Q9W385", "FBgn0030092", "CHEBI:33737", "P37193", "FBgn0011769", "Q8SZA8", "FBgn0035529", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "CHEBI:33739", "Q9W385", "FBgn0030092", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "species_111793", "Q9W385", "FBgn0030092", "Q8SZA8", "FBgn0035529", "CHEBI:33738", "P37193", "FBgn0011769" ] }, "reaction_10443243": { "compartment": "compartment_12045", "id": "reaction_10443243", "reactome": "R-DME-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211993", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211952" ], "modifiers": [ [ "species_10432787", "catalyst" ] ], "additional_components": [ "Q95078", "FBgn0010383", "Q9VWR5", "FBgn0004959" ] }, "reaction_10432790": { "compartment": "compartment_12045", "id": "reaction_10432790", "reactome": "R-DME-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39703", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76455" ], "modifiers": [ [ "species_10432787", "catalyst" ] ], "additional_components": [ "Q95078", "FBgn0010383", "Q9VWR5", "FBgn0004959" ] }, "reaction_10465550": { "compartment": "compartment_876", "id": "reaction_10465550", "reactome": "R-DME-2327746", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442018", "species_10442026" ], "products": [ "species_10465548" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "species_266099", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10442028": { "compartment": "compartment_876", "id": "reaction_10442028", "reactome": "R-DME-202723", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442020", "species_10442024", "species_266099" ], "products": [ "species_10442026" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "species_266099", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163" ] }, "reaction_10466200": { "compartment": "compartment_984", "id": "reaction_10466200", "reactome": "R-DME-2545196", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442018" ], "products": [ "species_10442020" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163" ] }, "reaction_10498752": { "compartment": "compartment_7660", "id": "reaction_10498752", "reactome": "R-DME-9708430", "name": "XPO1 (CRM1) binds to BACH1:Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498740", "species_10437629" ], "products": [ "species_10498742" ], "modifiers": [], "additional_components": [ "Q9VYJ8", "FBgn0030417", "FBgn0020497", "Q9TVM2", "FBgn0020497", "Q9VYJ8", "FBgn0030417" ] }, "reaction_10455099": { "compartment": "compartment_876", "id": "reaction_10455099", "reactome": "R-DME-917870", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310" ], "products": [ "species_9707308" ], "modifiers": [ [ "species_10441404", "catalyst" ] ], "additional_components": [ "species_71185", "B7YZU3", "FBgn0033387", "Q8INF8", "FBgn0051321", "Q9VY22", "FBgn0030576", "A1Z7R6", "FBgn0033388", "Q1EC10", "FBgn0050345", "Q9VA14", "FBgn0039817", "Q0E8E1", "FBgn0260388", "Q961H2", "FBgn0050344" ] }, "reaction_10498750": { "compartment": "compartment_70101", "id": "reaction_10498750", "reactome": "R-DME-9708423", "name": "XPO1:BACH1:Hemes are transported out of the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498742" ], "products": [ "species_10498748" ], "modifiers": [], "additional_components": [ "Q9TVM2", "FBgn0020497", "Q9VYJ8", "FBgn0030417", "Q9VYJ8", "FBgn0030417", "Q9TVM2", "FBgn0020497" ] }, "reaction_10458287": { "compartment": "compartment_70101", "id": "reaction_10458287", "reactome": "R-DME-1247665", "name": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425425", "species_352022" ], "products": [ "species_188972", "species_111627" ], "modifiers": [ [ "species_10458178", "catalyst" ] ], "additional_components": [ "Q9VT48", "FBgn0036043" ] }, "reaction_10458285": { "compartment": "compartment_70101", "id": "reaction_10458285", "reactome": "R-DME-1247649", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10449195", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872" ] }, "reaction_10458236": { "compartment": "compartment_984", "id": "reaction_10458236", "reactome": "R-DME-1237059", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10458231", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VH26", "FBgn0037788" ] }, "reaction_10458283": { "compartment": "compartment_70101", "id": "reaction_10458283", "reactome": "R-DME-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10450042", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10459562": { "compartment": "compartment_70101", "id": "reaction_10459562", "reactome": "R-DME-1475436", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10459557", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10458234": { "compartment": "compartment_984", "id": "reaction_10458234", "reactome": "R-DME-1237047", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10458231", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VH26", "FBgn0037788" ] }, "reaction_10459560": { "compartment": "compartment_70101", "id": "reaction_10459560", "reactome": "R-DME-1475435", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10459557", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10457039": { "compartment": "compartment_70101", "id": "reaction_10457039", "reactome": "R-DME-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456947", "species_113592", "species_10456941" ], "products": [ "species_111294", "species_10456939", "species_10457005", "species_76577" ], "modifiers": [ [ "species_10456947", "catalyst" ] ], "additional_components": [ "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10457007": { "compartment": "compartment_70101", "id": "reaction_10457007", "reactome": "R-DME-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457005" ], "products": [ "species_983123", "species_10456828" ], "modifiers": [], "additional_components": [ "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653" ] }, "reaction_10457036": { "compartment": "compartment_70101", "id": "reaction_10457036", "reactome": "R-DME-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457028", "species_113592", "species_29926", "species_10426987" ], "products": [ "species_111294", "species_10457030", "species_29926", "species_76577" ], "modifiers": [ [ "species_10457028", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10457033": { "compartment": "compartment_70101", "id": "reaction_10457033", "reactome": "R-DME-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457030", "species_10456939" ], "products": [ "species_10457028", "species_10456941" ], "modifiers": [ [ "species_10456939", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436" ] }, "reaction_10456950": { "compartment": "compartment_70101", "id": "reaction_10456950", "reactome": "R-DME-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10456943" ], "products": [ "species_111294", "species_10456947", "species_10456939", "species_76577" ], "modifiers": [ [ "species_10456828", "catalyst" ] ], "additional_components": [ "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653" ] }, "reaction_10457186": { "compartment": "compartment_70101", "id": "reaction_10457186", "reactome": "R-DME-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10457183", "catalyst" ] ], "additional_components": [ "Q9V6K1", "FBgn0020370", "X2JEJ0", "FBgn0030038", "Q8IRH1", "FBgn0261243", "Q0KI25", "FBgn0039064", "Q0KI00", "FBgn0263236", "Q9W2S8", "FBgn0030222", "Q9W2S7", "FBgn0030223", "Q9W1S1", "FBgn0046253", "Q9VTL4", "FBgn0036186", "Q9VJN2", "FBgn0028935", "Q9VD87", "FBgn0038897", "Q9VAM2", "FBgn0039656", "Q95SR0", "FBgn0051445", "Q8SWX4", "FBgn0051343", "Q8MRN5", "FBgn0051343" ] }, "reaction_10457041": { "compartment": "compartment_70101", "id": "reaction_10457041", "reactome": "R-DME-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983035", "species_10456828", "species_10456941" ], "products": [ "species_10456943" ], "modifiers": [], "additional_components": [ "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653" ] }, "reaction_10457009": { "compartment": "compartment_70101", "id": "reaction_10457009", "reactome": "R-DME-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_983032", "species_10426987", "species_8942986", "species_983036" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_209377": { "compartment": "compartment_984", "id": "reaction_209377", "reactome": "R-DME-209377", "name": "Polymeric PGN binds to PGRP-LCx at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCx, receptor exhibits strong affinity for both polymeric and monomeric peptidoglycans.", "reactants": [ "species_206912", "species_205794" ], "products": [ "species_207039" ], "modifiers": [], "additional_components": [ "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "species_214401", "CHEBI:28881", "species_1678743" ] }, "reaction_209355": { "compartment": "compartment_984", "id": "reaction_209355", "reactome": "R-DME-209355", "name": "Monomeric PGN binds to PGRP-LCx at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for peptidoglycans (PGN). However, PGRP-LCx receptor exhibits strong affinity for them.", "reactants": [ "species_205686", "species_205794" ], "products": [ "species_206681" ], "modifiers": [], "additional_components": [ "Q9GNK5-2", "PGRP-LCx", "species_214401" ] }, "reaction_214410": { "compartment": "compartment_70101", "id": "reaction_214410", "reactome": "R-DME-214410", "name": "Monomeric PGN binds to PGRP-LE in the cytosol", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LE receptor contains no predicted transmembrane domain or signal sequence and so is predicted to be an intracellular receptor. The recognition of the monomeric diaminopimelic acid (DAP)-type peptidoglycan (PGN) tracheal cytotoxin, TCT by PGRP-LE occurs intracellularly. However, it is postulated that the PGRP domain of a truncated PGRP-LE can also function outside the cell in a CD14-like manner by presenting DAP-type PGNs to cell surface PGRP-LC receptors.", "reactants": [ "species_214412", "species_214401" ], "products": [ "species_214396" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE" ] }, "reaction_214418": { "compartment": "compartment_70101", "id": "reaction_214418", "reactome": "R-DME-214418", "name": "REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The NF-kappaB orthologue, Relish, binds to the caspase-8 orthologue, DREDD.", "reactants": [ "species_214404", "species_206135" ], "products": [ "species_214406" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4" ] }, "reaction_209244": { "compartment": "compartment_70101", "id": "reaction_209244", "reactome": "R-DME-209244", "name": "REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The NF-kappaB orthologue, Relish, binds to the caspase-8 orthologue, DREDD.", "reactants": [ "species_354317", "species_206135" ], "products": [ "species_354323" ], "modifiers": [], "additional_components": [ "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_209221": { "compartment": "compartment_70101", "id": "reaction_209221", "reactome": "R-DME-209221", "name": "Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Upon ligand binding and receptor multimerisation at the plasma membrane, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the cytoplasmic part of the receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.", "reactants": [ "species_354313", "species_205887", "species_205876", "species_206183" ], "products": [ "species_354317" ], "modifiers": [], "additional_components": [ "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_214405": { "compartment": "compartment_70101", "id": "reaction_214405", "reactome": "R-DME-214405", "name": "Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Upon monomeric peptidoglycan (PGN) binding and receptor multimerisation in the cytosol, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the PGRP-LE receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.", "reactants": [ "species_205887", "species_205876", "species_206183", "species_354246" ], "products": [ "species_214404" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4" ] }, "reaction_10433119": { "compartment": "compartment_7660", "id": "reaction_10433119", "reactome": "R-DME-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433113", "species_72084", "species_29428" ], "products": [ "species_10433117" ], "modifiers": [], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433149": { "compartment": "compartment_7660", "id": "reaction_10433149", "reactome": "R-DME-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429248", "species_10429169" ], "products": [ "species_10429250" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10433131": { "compartment": "compartment_7660", "id": "reaction_10433131", "reactome": "R-DME-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433121", "species_113571" ], "products": [ "species_10433128", "species_111349" ], "modifiers": [ [ "species_10433121", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "species_5696194", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433147": { "compartment": "compartment_7660", "id": "reaction_10433147", "reactome": "R-DME-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429162", "species_10429167" ], "products": [ "species_10429169" ], "modifiers": [], "additional_components": [ "FBgn0022943", "FBgn0022942", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10433115": { "compartment": "compartment_7660", "id": "reaction_10433115", "reactome": "R-DME-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433105", "species_10433089", "species_10433111" ], "products": [ "species_10433113" ], "modifiers": [], "additional_components": [ "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "FBgn0040273", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433145": { "compartment": "compartment_7660", "id": "reaction_10433145", "reactome": "R-DME-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10433138" ], "products": [ "species_10429248", "species_77502", "species_10431174", "species_10433142", "species_10433111" ], "modifiers": [ [ "species_10433138", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VY44", "FBgn0030556", "Q9VJQ4", "FBgn0286027", "FBgn0040273", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433095": { "compartment": "compartment_7660", "id": "reaction_10433095", "reactome": "R-DME-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433093", "species_10433087" ], "products": [ "species_10433089" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "FBgn0030556", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10433124": { "compartment": "compartment_7660", "id": "reaction_10433124", "reactome": "R-DME-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433117" ], "products": [ "species_113550", "species_10433121" ], "modifiers": [ [ "species_10433117", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433140": { "compartment": "compartment_7660", "id": "reaction_10433140", "reactome": "R-DME-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433133" ], "products": [ "species_10433138" ], "modifiers": [], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433091": { "compartment": "compartment_7660", "id": "reaction_10433091", "reactome": "R-DME-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433089" ], "products": [ "species_10433089" ], "modifiers": [], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10433136": { "compartment": "compartment_7660", "id": "reaction_10433136", "reactome": "R-DME-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433128" ], "products": [ "species_10433133" ], "modifiers": [ [ "species_10433128", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "species_5696194", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "species_5696194" ] }, "reaction_10479695": { "compartment": "compartment_984", "id": "reaction_10479695", "reactome": "R-DME-6785213", "name": "LIPC dimer binds heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1604784", "species_10478382" ], "products": [ "species_10478384" ], "modifiers": [], "additional_components": [ "Q9VB91", "FBgn0039473", "A1ZAL5", "FBgn0034166", "Q9VX70", "FBgn0265267", "Q9VB90", "FBgn0039474", "Q9VX69", "FBgn0030828", "Q9VB89", "FBgn0039475", "Q9VX01", "FBgn0030884", "Q9VB88", "FBgn0039476", "Q9VU78", "FBgn0036367", "Q7K3Z8", "FBgn0032029", "Q9VRW5", "FBgn0035697", "Q4V566", "FBgn0085476", "Q9VLU1", "FBgn0031976", "Q0E8T1", "FBgn0250847", "Q9VJH1", "FBgn0032612", "P06607", "FBgn0004047", "Q9VEY9", "FBgn0038398", "P02844", "FBgn0005391", "Q9VBQ2", "FBgn0039344", "P02843", "FBgn0004045", "Q9VB94", "FBgn0039470", "M9NFL7", "FBgn0036977", "Q9W448", "FBgn0029831", "Q9VB93", "FBgn0039471", "M9MRT1", "FBgn0032289", "Q9W304", "FBgn0030162", "Q9VB92", "FBgn0039472", "A8DYT7", "FBgn0085477", "Q9VZN6", "FBgn0035453", "Q9VB91", "FBgn0039473", "A1ZAL5", "FBgn0034166", "Q9VX70", "FBgn0265267", "Q9VB90", "FBgn0039474", "Q9VX69", "FBgn0030828", "Q9VB89", "FBgn0039475", "Q9VX01", "FBgn0030884", "Q9VB88", "FBgn0039476", "Q9VU78", "FBgn0036367", "Q7K3Z8", "FBgn0032029", "Q9VRW5", "FBgn0035697", "Q4V566", "FBgn0085476", "Q9VLU1", "FBgn0031976", "Q0E8T1", "FBgn0250847", "Q9VJH1", "FBgn0032612", "P06607", "FBgn0004047", "Q9VEY9", "FBgn0038398", "P02844", "FBgn0005391", "Q9VBQ2", "FBgn0039344", "P02843", "FBgn0004045", "Q9VB94", "FBgn0039470", "M9NFL7", "FBgn0036977", "Q9W448", "FBgn0029831", "Q9VB93", "FBgn0039471", "M9MRT1", "FBgn0032289", "Q9W304", "FBgn0030162", "Q9VB92", "FBgn0039472", "A8DYT7", "FBgn0085477", "Q9VZN6", "FBgn0035453", "species_1604784" ] }, "reaction_10479623": { "compartment": "compartment_984", "id": "reaction_10479623", "reactome": "R-DME-6784861", "name": "HSPG binds LPL dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479619", "species_1678620" ], "products": [ "species_10479621" ], "modifiers": [], "additional_components": [ "Q9VB90", "FBgn0039474", "Q9VB89", "FBgn0039475", "Q9VB88", "FBgn0039476", "Q7K3Z8", "FBgn0032029", "Q4V566", "FBgn0085476", "Q0E8T1", "FBgn0250847", "P06607", "FBgn0004047", "P02844", "FBgn0005391", "P02843", "FBgn0004045", "M9NFL7", "FBgn0036977", "M9MRT1", "FBgn0032289", "A8DYT7", "FBgn0085477", "A1ZAL5", "FBgn0034166", "Q9W448", "FBgn0029831", "Q9W304", "FBgn0030162", "Q9VZN6", "FBgn0035453", "Q9VX70", "FBgn0265267", "Q9VX69", "FBgn0030828", "Q9VX01", "FBgn0030884", "Q9VU78", "FBgn0036367", "Q9VRW5", "FBgn0035697", "Q9VLU1", "FBgn0031976", "Q9VJH1", "FBgn0032612", "Q9VEY9", "FBgn0038398", "Q9VBQ2", "FBgn0039344", "Q9VB94", "FBgn0039470", "Q9VB93", "FBgn0039471", "Q9VB92", "FBgn0039472", "Q9VB91", "FBgn0039473", "species_1678620", "Q9VB90", "FBgn0039474", "Q9VB89", "FBgn0039475", "Q9VB88", "FBgn0039476", "Q7K3Z8", "FBgn0032029", "Q4V566", "FBgn0085476", "Q0E8T1", "FBgn0250847", "P06607", "FBgn0004047", "P02844", "FBgn0005391", "P02843", "FBgn0004045", "M9NFL7", "FBgn0036977", "M9MRT1", "FBgn0032289", "A8DYT7", "FBgn0085477", "A1ZAL5", "FBgn0034166", "Q9W448", "FBgn0029831", "Q9W304", "FBgn0030162", "Q9VZN6", "FBgn0035453", "Q9VX70", "FBgn0265267", "Q9VX69", "FBgn0030828", "Q9VX01", "FBgn0030884", "Q9VU78", "FBgn0036367", "Q9VRW5", "FBgn0035697", "Q9VLU1", "FBgn0031976", "Q9VJH1", "FBgn0032612", "Q9VEY9", "FBgn0038398", "Q9VBQ2", "FBgn0039344", "Q9VB94", "FBgn0039470", "Q9VB93", "FBgn0039471", "Q9VB92", "FBgn0039472", "Q9VB91", "FBgn0039473" ] }, "reaction_10478387": { "compartment": "compartment_984", "id": "reaction_10478387", "reactome": "R-DME-5694109", "name": "LIPC dimer hydrolyses TAG to DAG and FA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_422024", "species_174675" ], "modifiers": [ [ "species_10478384", "catalyst" ] ], "additional_components": [ "Q9VB91", "FBgn0039473", "A1ZAL5", "FBgn0034166", "Q9VX70", "FBgn0265267", "Q9VB90", "FBgn0039474", "Q9VX69", "FBgn0030828", "Q9VB89", "FBgn0039475", "Q9VX01", "FBgn0030884", "Q9VB88", "FBgn0039476", "Q9VU78", "FBgn0036367", "Q7K3Z8", "FBgn0032029", "Q9VRW5", "FBgn0035697", "Q4V566", "FBgn0085476", "Q9VLU1", "FBgn0031976", "Q0E8T1", "FBgn0250847", "Q9VJH1", "FBgn0032612", "P06607", "FBgn0004047", "Q9VEY9", "FBgn0038398", "P02844", "FBgn0005391", "Q9VBQ2", "FBgn0039344", "P02843", "FBgn0004045", "Q9VB94", "FBgn0039470", "M9NFL7", "FBgn0036977", "Q9W448", "FBgn0029831", "Q9VB93", "FBgn0039471", "M9MRT1", "FBgn0032289", "Q9W304", "FBgn0030162", "Q9VB92", "FBgn0039472", "A8DYT7", "FBgn0085477", "Q9VZN6", "FBgn0035453", "species_1604784" ] }, "reaction_10435351": { "compartment": "compartment_984", "id": "reaction_10435351", "reactome": "R-DME-140806", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435285", "species_9693058" ], "products": [ "species_10435349" ], "modifiers": [], "additional_components": [ "Q0E8V6", "FBgn0051902", "Q9VFC1", "FBgn0038299", "Q0E8C8", "FBgn0262057", "Q9VA48", "FBgn0039795", "Q9VWB4", "FBgn0036969", "A1Z6V5", "FBgn0024293", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q9VVW1", "FBgn0015586", "A1Z6R4", "FBgn0033113", "Q8SYY7", "FBgn0044011", "Q9VPH9", "FBgn0036970", "A1Z6R3", "FBgn0033112", "Q7YTY6", "FBgn0028988", "Q9VLZ8", "FBgn0083141", "A1Z6I3", "FBgn0263109", "Q7KA66", "FBgn0024294", "Q9VLV3", "FBgn0053121", "Q7K8Y5", "FBgn0265137", "Q9VLU4", "FBgn0031973", "Q7K508", "FBgn0033574", "Q9VLQ7", "FBgn0028987", "Q7JWX3", "FBgn0002930", "Q9VL44", "FBgn0032178", "Q7JV69", "FBgn0028983", "Q9VII7", "FBgn0028986", "Q4V3G2", "FBgn0034195", "Q9VH46", "FBgn0037772", "Q3HKQ3", "FBgn0052203", "Q9VFC2", "FBgn0028984", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902" ] }, "reaction_10472771": { "compartment": "compartment_984", "id": "reaction_10472771", "reactome": "R-DME-5591086", "name": "SERPINA5 binds activated protein C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472753", "species_10472767" ], "products": [ "species_10472769" ], "modifiers": [ [ "species_977180", "catalyst" ] ], "additional_components": [ "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178" ] }, "reaction_10496558": { "compartment": "compartment_984", "id": "reaction_10496558", "reactome": "R-DME-9015111", "name": "Factor Xa inhibitors binds Xa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9038743", "species_10496554" ], "products": [ "species_10496556" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016" ] }, "reaction_10465672": { "compartment": "compartment_984", "id": "reaction_10465672", "reactome": "R-DME-2396079", "name": "VTN binds Plasminogen activator inhibitor- 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443474", "species_10452309" ], "products": [ "species_10465670" ], "modifiers": [], "additional_components": [ "FBgn0024366", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "O46099", "FBgn0024366" ] }, "reaction_10466600": { "compartment": "compartment_984", "id": "reaction_10466600", "reactome": "R-DME-2681681", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451", "species_10465757" ], "products": [ "species_10466598" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163" ] }, "reaction_10465811": { "compartment": "compartment_876", "id": "reaction_10465811", "reactome": "R-DME-2426471", "name": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443474", "species_10443447" ], "products": [ "species_10465809" ], "modifiers": [], "additional_components": [ "FBgn0024366", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "O46099", "FBgn0024366" ] }, "reaction_10465968": { "compartment": "compartment_984", "id": "reaction_10465968", "reactome": "R-DME-2467665", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465960", "species_10465964" ], "products": [ "species_10465966" ], "modifiers": [], "additional_components": [ "FBgn0015773", "P14599", "FBgn0000108", "P14599", "FBgn0000108", "Q24567", "FBgn0015773" ] }, "reaction_10462495": { "compartment": "compartment_12045", "id": "reaction_10462495", "reactome": "R-DME-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10462488", "species_1650779" ], "products": [ "species_1650769", "species_159751", "species_10462492" ], "modifiers": [ [ "species_10462486", "catalyst" ] ], "additional_components": [ "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793" ] }, "reaction_10462527": { "compartment": "compartment_12045", "id": "reaction_10462527", "reactome": "R-DME-1981157", "name": "Glucosylation of collagen propeptide hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462517", "species_173594" ], "products": [ "species_158602", "species_10462524" ], "modifiers": [ [ "species_10462484", "catalyst" ] ], "additional_components": [ "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147" ] }, "reaction_10462555": { "compartment": "compartment_17957", "id": "reaction_10462555", "reactome": "R-DME-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462529" ], "products": [ "species_10462553" ], "modifiers": [], "additional_components": [ "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10493353": { "compartment": "compartment_17957", "id": "reaction_10493353", "reactome": "R-DME-8944257", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462830" ], "products": [ "species_10462854" ], "modifiers": [], "additional_components": [ "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10462622": { "compartment": "compartment_984", "id": "reaction_10462622", "reactome": "R-DME-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462581" ], "products": [ "species_10462607" ], "modifiers": [ [ "species_10462619", "catalyst" ] ], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468", "Q9VC47", "FBgn0004885", "P25723", "FBgn0003719" ] }, "reaction_10462520": { "compartment": "compartment_12045", "id": "reaction_10462520", "reactome": "R-DME-1981128", "name": "Galactosylation of collagen propeptide hydroxylysines by PLOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10462515" ], "products": [ "species_10462517", "species_158602" ], "modifiers": [ [ "species_10462484", "catalyst" ] ], "additional_components": [ "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147" ] }, "reaction_10462629": { "compartment": "compartment_984", "id": "reaction_10462629", "reactome": "R-DME-2002440", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462607" ], "products": [ "species_10459392" ], "modifiers": [ [ "species_10462626", "catalyst" ] ], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468", "Q9VC47", "FBgn0004885", "P25723", "FBgn0003719" ] }, "reaction_10462513": { "compartment": "compartment_17957", "id": "reaction_10462513", "reactome": "R-DME-1981120", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10462506" ], "products": [ "species_158602", "species_10462510" ], "modifiers": [ [ "species_10462506", "catalyst" ] ], "additional_components": [ "Q8IPK4", "FBgn0051915", "Q8IPK4", "FBgn0051915", "Q8IPK4", "FBgn0051915" ] }, "reaction_10443439": { "compartment": "compartment_984", "id": "reaction_10443439", "reactome": "R-DME-216048", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443380", "species_10443435" ], "products": [ "species_10443437" ], "modifiers": [], "additional_components": [ "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q9W4Y3", "FBgn0284408", "Q8IP51", "FBgn0261563", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q9W4Y3", "FBgn0284408", "Q8IP51", "FBgn0261563", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657" ] }, "reaction_10469164": { "compartment": "compartment_876", "id": "reaction_10469164", "reactome": "R-DME-3907292", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469158", "species_10469160" ], "products": [ "species_10469162" ], "modifiers": [], "additional_components": [ "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "Q9W4Y3", "FBgn0284408", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "Q9W4Y3", "FBgn0284408", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "P11584", "FBgn0004657" ] }, "reaction_10443932": { "compartment": "compartment_984", "id": "reaction_10443932", "reactome": "R-DME-349626", "name": "Integrin alpha2beta1 binds laminin-332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443411", "species_10443928" ], "products": [ "species_10443930" ], "modifiers": [], "additional_components": [ "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10443465": { "compartment": "compartment_984", "id": "reaction_10443465", "reactome": "R-DME-216058", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443459", "species_10443461" ], "products": [ "species_10443463" ], "modifiers": [], "additional_components": [ "P11584", "FBgn0004657", "Q24247", "FBgn0004456", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "P11584", "FBgn0004657", "Q24247", "FBgn0004456" ] }, "reaction_10466975": { "compartment": "compartment_876", "id": "reaction_10466975", "reactome": "R-DME-2731074", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463847", "species_10466971" ], "products": [ "species_10466973" ], "modifiers": [], "additional_components": [ "FBgn0010415", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P49415", "FBgn0010415" ] }, "reaction_10466987": { "compartment": "compartment_876", "id": "reaction_10466987", "reactome": "R-DME-2731141", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463847", "species_10443451" ], "products": [ "species_10466985" ], "modifiers": [], "additional_components": [ "FBgn0010415", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P49415", "FBgn0010415" ] }, "reaction_10466983": { "compartment": "compartment_876", "id": "reaction_10466983", "reactome": "R-DME-2731122", "name": "Syndecans 1, 2 & 4 bind VTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443474", "species_10463847" ], "products": [ "species_10466981" ], "modifiers": [], "additional_components": [ "FBgn0024366", "FBgn0010415", "P49415", "FBgn0010415", "O46099", "FBgn0024366" ] }, "reaction_10467077": { "compartment": "compartment_876", "id": "reaction_10467077", "reactome": "R-DME-2750187", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467073", "species_10447182" ], "products": [ "species_10467075" ], "modifiers": [], "additional_components": [ "P49415", "FBgn0010415", "species_179856", "species_114519", "P05130", "FBgn0003091", "species_114519", "P05130", "FBgn0003091", "P49415", "FBgn0010415", "species_179856" ] }, "reaction_10466979": { "compartment": "compartment_876", "id": "reaction_10466979", "reactome": "R-DME-2731078", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437858", "species_10463849" ], "products": [ "species_10466977" ], "modifiers": [], "additional_components": [ "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "FBgn0010415", "P49415", "FBgn0010415", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10443455": { "compartment": "compartment_984", "id": "reaction_10443455", "reactome": "R-DME-216050", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443449", "species_10443451" ], "products": [ "species_10443453" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "P11584", "FBgn0004657", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10498486": { "compartment": "compartment_876", "id": "reaction_10498486", "reactome": "R-DME-9679740", "name": "ITGA4:ITGB1 binds natalizumab", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9679737", "species_10441036" ], "products": [ "species_10498484" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10469592": { "compartment": "compartment_984", "id": "reaction_10469592", "reactome": "R-DME-4085133", "name": "LUM (lumican) binds integrin alpha2beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469588", "species_10443928" ], "products": [ "species_10469590" ], "modifiers": [], "additional_components": [ "FBgn0028872", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "M9MSI4", "FBgn0028872" ] }, "reaction_10443635": { "compartment": "compartment_876", "id": "reaction_10443635", "reactome": "R-DME-265422", "name": "Interaction of integrin alphaEbeta7 with Cadherin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442033", "species_10443631" ], "products": [ "species_10443633" ], "modifiers": [], "additional_components": [ "FBgn0262018", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "Q9VJB6", "FBgn0262018" ] }, "reaction_10465779": { "compartment": "compartment_984", "id": "reaction_10465779", "reactome": "R-DME-2426259", "name": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465761", "species_10442024" ], "products": [ "species_10465777" ], "modifiers": [], "additional_components": [ "Q9VM97", "FBgn0031850", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q9VM97", "FBgn0031850" ] }, "reaction_10443648": { "compartment": "compartment_984", "id": "reaction_10443648", "reactome": "R-DME-265429", "name": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443642", "species_10443644" ], "products": [ "species_10443646" ], "modifiers": [], "additional_components": [ "Q9VM97", "FBgn0031850", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "O44386", "FBgn0286785", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "O44386", "FBgn0286785", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "Q9VM97", "FBgn0031850" ] }, "reaction_10465638": { "compartment": "compartment_984", "id": "reaction_10465638", "reactome": "R-DME-2395364", "name": "LTBP4 binds TGF-Beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465600", "species_10465570" ], "products": [ "species_10465636" ], "modifiers": [], "additional_components": [ "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P98163", "FBgn0004649", "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649", "Q9V4B8", "FBgn0051999", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234" ] }, "reaction_10465606": { "compartment": "compartment_876", "id": "reaction_10465606", "reactome": "R-DME-2395320", "name": "Latent TGF-beta-1 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465600", "species_10465602" ], "products": [ "species_10465604" ], "modifiers": [], "additional_components": [ "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234" ] }, "reaction_10465668": { "compartment": "compartment_876", "id": "reaction_10465668", "reactome": "R-DME-2396029", "name": "Latent TGF-beta-3 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443447", "species_10465628" ], "products": [ "species_10465666" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10465634": { "compartment": "compartment_984", "id": "reaction_10465634", "reactome": "R-DME-2395328", "name": "LTBP1, LTBP3 bind TGF-Beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465608", "species_10465630" ], "products": [ "species_10465632" ], "modifiers": [], "additional_components": [ "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649" ] }, "reaction_10489074": { "compartment": "compartment_876", "id": "reaction_10489074", "reactome": "R-DME-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489064" ], "products": [ "species_10489072" ], "modifiers": [], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "A8JRD0", "FBgn0066101", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "A8JRD0", "FBgn0066101" ] }, "reaction_10493840": { "compartment": "compartment_7660", "id": "reaction_10493840", "reactome": "R-DME-8952128", "name": "RUNX3 binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10467611" ], "products": [ "species_10493838" ], "modifiers": [], "additional_components": [ "FBgn0083981", "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "M9PI08", "FBgn0083981" ] }, "reaction_10491733": { "compartment": "compartment_7660", "id": "reaction_10491733", "reactome": "R-DME-8878117", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10491729" ], "products": [ "species_10491731" ], "modifiers": [ [ "species_10437860", "catalyst" ] ], "additional_components": [ "FBgn0083981", "FBgn0004607", "P28167", "FBgn0004607", "M9PI08", "FBgn0083981", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10491740": { "compartment": "compartment_7660", "id": "reaction_10491740", "reactome": "R-DME-8878143", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10491736" ], "products": [ "species_10491738" ], "modifiers": [], "additional_components": [ "FBgn0083981", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "M9PI08", "FBgn0083981" ] }, "reaction_10436609": { "compartment": "compartment_7660", "id": "reaction_10436609", "reactome": "R-DME-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10436603" ], "products": [ "species_10436607" ], "modifiers": [], "additional_components": [ "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357", "species_76577", "A1Z7Q8", "FBgn0260972" ] }, "reaction_10489849": { "compartment": "compartment_7660", "id": "reaction_10489849", "reactome": "R-DME-8865613", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489819", "species_10489827" ], "products": [ "species_10489847" ], "modifiers": [], "additional_components": [ "FBgn0011785", "FBgn0001199", "P02299", "FBgn0001199", "Q9VC96", "FBgn0011785" ] }, "reaction_10489823": { "compartment": "compartment_7660", "id": "reaction_10489823", "reactome": "R-DME-8865605", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489819", "species_10467677" ], "products": [ "species_10489821" ], "modifiers": [], "additional_components": [ "FBgn0011785", "FBgn0000212", "P25439", "FBgn0000212", "Q9VC96", "FBgn0011785" ] }, "reaction_10454519": { "compartment": "compartment_13231", "id": "reaction_10454519", "reactome": "R-DME-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454427" ], "products": [ "species_10454513" ], "modifiers": [ [ "species_10454517", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E", "O18388", "FBgn0262743", "Q24151", "Stat92E", "O76521", "FBgn0024889" ] }, "reaction_10454155": { "compartment": "compartment_13231", "id": "reaction_10454155", "reactome": "R-DME-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454149" ], "products": [ "species_10454153" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10496089": { "compartment": "compartment_70101", "id": "reaction_10496089", "reactome": "R-DME-9009950", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8983696" ], "products": [ "species_70106", "species_113592", "species_76577" ], "modifiers": [ [ "species_10496086", "catalyst" ] ], "additional_components": [ "species_113592", "FBgn0051759" ] }, "reaction_10461341": { "compartment": "compartment_70101", "id": "reaction_10461341", "reactome": "R-DME-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461329", "species_10461337" ], "products": [ "species_10461335", "species_10461339" ], "modifiers": [], "additional_components": [ "Q94981", "FBgn0017418", "E8NHA2", "FBgn0035207", "Q9VZ73", "FBgn0035584", "Q7K738", "FBgn0026316", "P52487", "FBgn0017456", "E1JIV5", "FBgn0053100", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A8DZ29", "FBgn0023213", "Q9VCH1", "FBgn0260634", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A8DZ29", "FBgn0023213", "Q9VCH1", "FBgn0260634", "Q94981", "FBgn0017418", "E8NHA2", "FBgn0035207", "Q9VZ73", "FBgn0035584", "Q7K738", "FBgn0026316", "P52487", "FBgn0017456", "E1JIV5", "FBgn0053100" ] }, "reaction_10453068": { "compartment": "compartment_5460", "id": "reaction_10453068", "reactome": "R-DME-507775", "name": "PXLP-K341-GPT2 transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_379697" ], "products": [ "species_113557", "species_113552" ], "modifiers": [ [ "species_10453063", "catalyst" ] ], "additional_components": [ "Q9VYD9", "FBgn0030478" ] }, "reaction_10428164": { "compartment": "compartment_70101", "id": "reaction_10428164", "reactome": "R-DME-70524", "name": "PXLP-K314-GPT transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_29398" ], "products": [ "species_29406", "species_29432" ], "modifiers": [ [ "species_10428159", "catalyst" ] ], "additional_components": [ "Q9VYD9", "FBgn0030478" ] }, "reaction_10443038": { "compartment": "compartment_70101", "id": "reaction_10443038", "reactome": "R-DME-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10443035" ], "products": [ "species_10442948" ], "modifiers": [ [ "species_10443035", "catalyst" ] ], "additional_components": [ "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P25228", "FBgn0005586", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P25228", "FBgn0005586" ] }, "reaction_10442860": { "compartment": "compartment_984", "id": "reaction_10442860", "reactome": "R-DME-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_210382", "species_29804", "species_74113" ], "products": [ "species_74126", "species_29404", "species_70106", "species_83910" ], "modifiers": [ [ "species_10442846", "catalyst" ], [ "species_10442858", "inhibitor" ] ], "additional_components": [ "FBgn0026438", "FBgn0032704" ] }, "reaction_10428262": { "compartment": "compartment_5460", "id": "reaction_10428262", "reactome": "R-DME-70609", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113522", "species_113521" ], "products": [ "species_113561", "species_113552" ], "modifiers": [ [ "species_10428259", "catalyst" ] ], "additional_components": [ "Q1RL13", "FBgn0261625" ] }, "reaction_10443028": { "compartment": "compartment_984", "id": "reaction_10443028", "reactome": "R-DME-210430", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443005", "species_74016" ], "products": [ "species_10443025", "species_210382", "species_10443011", "species_10442919", "species_10443003", "species_10442973", "species_10443021", "species_10443023" ], "modifiers": [ [ "species_10443005", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0031424", "FBgn0004574", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "species_74016", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q24547", "FBgn0013343" ] }, "reaction_10443008": { "compartment": "compartment_70101", "id": "reaction_10443008", "reactome": "R-DME-210426", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10442948", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10443005" ], "modifiers": [ [ "species_10442948", "catalyst" ], [ "species_10442988", "catalyst" ] ], "additional_components": [ "FBgn0013343", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q24547", "FBgn0013343", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "FBgn0025726" ] }, "reaction_10480942": { "compartment": "compartment_7660", "id": "reaction_10480942", "reactome": "R-DME-6791235", "name": "GADD45A binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480938", "species_10480365" ], "products": [ "species_10480940" ], "modifiers": [], "additional_components": [ "FBgn0000147", "FBgn0033153", "A1Z6W5", "FBgn0033153", "Q9VGF9", "FBgn0000147" ] }, "reaction_10485962": { "compartment": "compartment_70101", "id": "reaction_10485962", "reactome": "R-DME-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432002", "species_10437611" ], "products": [ "species_10485960" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P29310", "14-3-3zeta" ] }, "reaction_10485964": { "compartment": "compartment_70101", "id": "reaction_10485964", "reactome": "R-DME-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432000" ], "products": [ "species_10432002" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta" ] }, "reaction_10480369": { "compartment": "compartment_7660", "id": "reaction_10480369", "reactome": "R-DME-6791109", "name": "GADD45A binds PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427633", "species_10480365" ], "products": [ "species_10480367" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "FBgn0033153", "A1Z6W5", "FBgn0033153", "P17917", "FBgn0005655" ] }, "reaction_10432502": { "compartment": "compartment_70101", "id": "reaction_10432502", "reactome": "R-DME-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75973", "species_29364" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10432499", "catalyst" ] ], "additional_components": [ "FBgn0027583" ] }, "reaction_10498530": { "compartment": "compartment_70101", "id": "reaction_10498530", "reactome": "R-DME-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10469475" ], "products": [ "species_10489943" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10489892": { "compartment": "compartment_70101", "id": "reaction_10489892", "reactome": "R-DME-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489882", "species_10489888" ], "products": [ "species_10489890" ], "modifiers": [], "additional_components": [ "Q8IPM2", "FBgn0051528", "Q9VHX2", "FBgn0037538", "Q9VWD9", "FBgn0031057", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q8IPM2", "FBgn0051528", "Q9VHX2", "FBgn0037538", "Q9VWD9", "FBgn0031057" ] }, "reaction_10489638": { "compartment": "compartment_70101", "id": "reaction_10489638", "reactome": "R-DME-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489614", "species_10489598", "species_10489634" ], "products": [ "species_10489636" ], "modifiers": [], "additional_components": [ "O77277", "FBgn0025615", "FBgn0016975", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "O77277", "FBgn0025615", "Q24212", "FBgn0016975" ] }, "reaction_10489576": { "compartment": "compartment_876", "id": "reaction_10489576", "reactome": "R-DME-8863472", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489560", "species_10489572" ], "products": [ "species_10489574" ], "modifiers": [], "additional_components": [ "FBgn0000414", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414" ] }, "reaction_10489641": { "compartment": "compartment_70101", "id": "reaction_10489641", "reactome": "R-DME-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489636" ], "products": [ "species_10489614", "species_10477764", "species_10489634", "species_10489552" ], "modifiers": [ [ "species_10489636", "catalyst" ] ], "additional_components": [ "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "O77277", "FBgn0025615", "Q24212", "FBgn0016975", "O77277", "FBgn0025615", "FBgn0032725", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "FBgn0016975", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "O77277", "FBgn0025615", "Q24212", "FBgn0016975" ] }, "reaction_10489963": { "compartment": "compartment_876", "id": "reaction_10489963", "reactome": "R-DME-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489959", "species_10489888" ], "products": [ "species_10489961" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VS85", "FBgn0028582", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341" ] }, "reaction_10489643": { "compartment": "compartment_70101", "id": "reaction_10489643", "reactome": "R-DME-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477764", "species_10489552" ], "products": [ "species_10489598" ], "modifiers": [], "additional_components": [ "FBgn0032725", "FBgn0016975", "FBgn0016975" ] }, "reaction_10489969": { "compartment": "compartment_876", "id": "reaction_10489969", "reactome": "R-DME-8866283", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489853", "species_10489365" ], "products": [ "species_10489965" ], "modifiers": [ [ "species_10489967", "inhibitor" ] ], "additional_components": [ "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q8IPM2", "FBgn0051528", "Q9VHX2", "FBgn0037538", "Q9VWD9", "FBgn0031057", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582" ] }, "reaction_10490099": { "compartment": "compartment_876", "id": "reaction_10490099", "reactome": "R-DME-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490093", "species_10490091" ], "products": [ "species_10490097" ], "modifiers": [], "additional_components": [ "FBgn0086372", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372" ] }, "reaction_10489558": { "compartment": "compartment_876", "id": "reaction_10489558", "reactome": "R-DME-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489547", "species_10489552" ], "products": [ "species_10489556" ], "modifiers": [], "additional_components": [ "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "FBgn0016975", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090" ] }, "reaction_10489945": { "compartment": "compartment_876", "id": "reaction_10489945", "reactome": "R-DME-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469475", "species_10489939" ], "products": [ "species_10489941" ], "modifiers": [ [ "species_10489943", "inhibitor" ] ], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10489595": { "compartment": "compartment_876", "id": "reaction_10489595", "reactome": "R-DME-8863718", "name": "AGFG1 binds VAMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489591", "species_10489589" ], "products": [ "species_10489593" ], "modifiers": [], "additional_components": [ "FBgn0266186", "FBgn0020304", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186" ] }, "reaction_10489855": { "compartment": "compartment_876", "id": "reaction_10489855", "reactome": "R-DME-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489851", "species_10474367" ], "products": [ "species_10489853" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10484330": { "compartment": "compartment_7660", "id": "reaction_10484330", "reactome": "R-DME-6799246", "name": "CHEK1 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427808", "species_29358" ], "products": [ "species_113582", "species_10427813" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0261278" ] }, "reaction_10438565": { "compartment": "compartment_7660", "id": "reaction_10438565", "reactome": "R-DME-176116", "name": "Recruitment and activation of Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438550" ], "products": [ "species_113582", "species_10427785" ], "modifiers": [ [ "species_10438562", "catalyst" ] ], "additional_components": [ "FBgn0261278", "FBgn0261278", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367" ] }, "reaction_10432380": { "compartment": "compartment_7660", "id": "reaction_10432380", "reactome": "R-DME-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10431972" ], "products": [ "species_113582", "species_10431980" ], "modifiers": [ [ "species_10427797", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0019686" ] }, "reaction_10497068": { "compartment": "compartment_70101", "id": "reaction_10497068", "reactome": "R-DME-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431980" ], "products": [ "species_10431988" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10498000": { "compartment": "compartment_17938", "id": "reaction_10498000", "reactome": "R-DME-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10497993" ], "products": [ "species_10497997", "species_29420" ], "modifiers": [ [ "species_10497993", "catalyst" ] ], "additional_components": [ "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "species_29468", "species_29468", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "species_29468" ] }, "reaction_10498113": { "compartment": "compartment_17938", "id": "reaction_10498113", "reactome": "R-DME-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497982" ], "products": [ "species_29372", "species_10497986" ], "modifiers": [ [ "species_10497982", "catalyst" ], [ "species_10498111", "catalyst" ] ], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438", "Q9VS33", "FBgn0261111", "E3CTN7", "FBgn0036684" ] }, "reaction_10498116": { "compartment": "compartment_17938", "id": "reaction_10498116", "reactome": "R-DME-9645608", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497995", "species_10436975" ], "products": [ "species_10498002" ], "modifiers": [], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10497989": { "compartment": "compartment_17938", "id": "reaction_10497989", "reactome": "R-DME-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497982", "species_29420" ], "products": [ "species_29438", "species_10497986" ], "modifiers": [ [ "species_10497982", "catalyst" ] ], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438" ] }, "reaction_10498009": { "compartment": "compartment_17938", "id": "reaction_10498009", "reactome": "R-DME-9640195", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498004" ], "products": [ "species_29372", "species_10498006" ], "modifiers": [ [ "species_10498004", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VND8", "Rheb", "species_29438", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10498124": { "compartment": "compartment_17938", "id": "reaction_10498124", "reactome": "R-DME-9646468", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436956", "species_10498002" ], "products": [ "species_10498004" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29438", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10437161": { "compartment": "compartment_70616", "id": "reaction_10437161", "reactome": "R-DME-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437154" ], "products": [ "species_166216", "species_10437150" ], "modifiers": [], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872" ] }, "reaction_10437159": { "compartment": "compartment_70616", "id": "reaction_10437159", "reactome": "R-DME-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_166213", "species_10437150" ], "products": [ "species_10437152" ], "modifiers": [], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213" ] }, "reaction_10437157": { "compartment": "compartment_70616", "id": "reaction_10437157", "reactome": "R-DME-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437152" ], "products": [ "species_10437154" ], "modifiers": [ [ "species_10437152", "catalyst" ] ], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213" ] }, "reaction_10437560": { "compartment": "compartment_70616", "id": "reaction_10437560", "reactome": "R-DME-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10437150", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_113592", "species_29370", "species_29420", "species_29438" ] }, "reaction_10442079": { "compartment": "compartment_70101", "id": "reaction_10442079", "reactome": "R-DME-202960", "name": "Caspase mediated cleavage of C-IAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442065" ], "products": [ "species_10442071", "species_10442077" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "Q9XYF4", "FBgn0026404" ] }, "reaction_10497056": { "compartment": "compartment_7660", "id": "reaction_10497056", "reactome": "R-DME-9029680", "name": "Caspase-7 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434869" ], "products": [ "species_10444173" ], "modifiers": [], "additional_components": [ "Q9VET9", "FBgn0028381", "Q9VET9", "FBgn0028381" ] }, "reaction_10441599": { "compartment": "compartment_70101", "id": "reaction_10441599", "reactome": "R-DME-201608", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441593" ], "products": [ "species_10441595", "species_10441597" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0263391", "FBgn0263391", "FBgn0263391", "Q9XYF4", "FBgn0026404" ] }, "reaction_10442090": { "compartment": "compartment_70101", "id": "reaction_10442090", "reactome": "R-DME-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442084" ], "products": [ "species_10442086", "species_10442088" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0036372", "FBgn0036372", "FBgn0036372", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441658": { "compartment": "compartment_70101", "id": "reaction_10441658", "reactome": "R-DME-201637", "name": "Caspase-mediated cleavage of plectin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441643" ], "products": [ "species_10441645", "species_10441647" ], "modifiers": [ [ "species_10441655", "catalyst" ] ], "additional_components": [ "FBgn0013733", "FBgn0013733", "FBgn0013733", "O01382", "FBgn0019972" ] }, "reaction_10442101": { "compartment": "compartment_70101", "id": "reaction_10442101", "reactome": "R-DME-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442095" ], "products": [ "species_10442097", "species_10442099" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0250789", "FBgn0250789", "FBgn0250789", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441621": { "compartment": "compartment_70101", "id": "reaction_10441621", "reactome": "R-DME-201629", "name": "Caspase-mediated cleavage of Tau", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441615" ], "products": [ "species_10441617", "species_10441619" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0266579", "FBgn0266579", "FBgn0266579", "Q9XYF4", "FBgn0026404" ] }, "reaction_10443560": { "compartment": "compartment_7660", "id": "reaction_10443560", "reactome": "R-DME-264865", "name": "Caspase-mediated cleavage of Lamin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443537" ], "products": [ "species_10443543", "species_10443549" ], "modifiers": [ [ "species_10443557", "catalyst" ] ], "additional_components": [ "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q9VET9", "FBgn0028381" ] }, "reaction_10497066": { "compartment": "compartment_13231", "id": "reaction_10497066", "reactome": "R-DME-9029690", "name": "Caspase-6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497064" ], "products": [ "species_10443557" ], "modifiers": [], "additional_components": [ "Q9VET9", "FBgn0028381", "Q9VET9", "FBgn0028381" ] }, "reaction_10443568": { "compartment": "compartment_7660", "id": "reaction_10443568", "reactome": "R-DME-264871", "name": "Caspase-mediated cleavage of Lamin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443562" ], "products": [ "species_10443564", "species_10443566" ], "modifiers": [ [ "species_10443557", "catalyst" ] ], "additional_components": [ "FBgn0002525", "FBgn0002525", "FBgn0002525", "Q9VET9", "FBgn0028381" ] }, "reaction_10444150": { "compartment": "compartment_12045", "id": "reaction_10444150", "reactome": "R-DME-351894", "name": "Caspase mediated cleavage of BAP31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444141" ], "products": [ "species_10444145", "species_10444147", "species_10444143" ], "modifiers": [ [ "species_10444126", "catalyst" ] ], "additional_components": [ "FBgn0035165", "FBgn0035165", "FBgn0035165", "FBgn0035165", "O01382", "FBgn0019972" ] }, "reaction_10444118": { "compartment": "compartment_70101", "id": "reaction_10444118", "reactome": "R-DME-351849", "name": "Caspase-mediated cleavage of Etk", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444112" ], "products": [ "species_10444114", "species_10444116" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0003502", "FBgn0003502", "FBgn0003502", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441588": { "compartment": "compartment_70101", "id": "reaction_10441588", "reactome": "R-DME-201603", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441582" ], "products": [ "species_10441584", "species_10441586" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0259680", "FBgn0259680", "FBgn0259680", "Q9XYF4", "FBgn0026404" ] }, "reaction_10443314": { "compartment": "compartment_70101", "id": "reaction_10443314", "reactome": "R-DME-212552", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434441" ], "products": [ "species_10443312", "species_10443310" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0259680", "FBgn0259680", "FBgn0259680", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444176": { "compartment": "compartment_7660", "id": "reaction_10444176", "reactome": "R-DME-351936", "name": "Caspase-mediated cleavage of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438600" ], "products": [ "species_10444163", "species_10444165" ], "modifiers": [ [ "species_10444173", "catalyst" ] ], "additional_components": [ "FBgn0052251", "FBgn0052251", "FBgn0052251", "Q9VET9", "FBgn0028381" ] }, "reaction_10444238": { "compartment": "compartment_7660", "id": "reaction_10444238", "reactome": "R-DME-352268", "name": "Cleavage of Satb1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444232" ], "products": [ "species_10444234", "species_10444236" ], "modifiers": [ [ "species_10443557", "catalyst" ] ], "additional_components": [ "FBgn0020307", "FBgn0020307", "FBgn0020307", "Q9VET9", "FBgn0028381" ] }, "reaction_10442059": { "compartment": "compartment_70101", "id": "reaction_10442059", "reactome": "R-DME-202947", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442045" ], "products": [ "species_10442051", "species_10442057" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9VAS9", "FBgn0015589", "Q9Y1T2", "Apc2", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441610": { "compartment": "compartment_70101", "id": "reaction_10441610", "reactome": "R-DME-201611", "name": "Caspase-mediated cleavage of Rock-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604" ], "products": [ "species_10441606", "species_10441608" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0026181", "FBgn0026181", "FBgn0026181", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441669": { "compartment": "compartment_70101", "id": "reaction_10441669", "reactome": "R-DME-201640", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441663" ], "products": [ "species_10441665", "species_10441667" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0031633", "FBgn0031633", "FBgn0031633", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444035": { "compartment": "compartment_70101", "id": "reaction_10444035", "reactome": "R-DME-350651", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444029" ], "products": [ "species_10444033", "species_10444031" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0266465", "FBgn0266465", "FBgn0266465", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444161": { "compartment": "compartment_70101", "id": "reaction_10444161", "reactome": "R-DME-351901", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444152" ], "products": [ "species_10444154", "species_10444156" ], "modifiers": [ [ "species_10444158", "catalyst" ] ], "additional_components": [ "FBgn0266465", "FBgn0266465", "FBgn0266465", "Q9XYF4", "FBgn0026404", "Q9VET9", "FBgn0028381" ] }, "reaction_10442109": { "compartment": "compartment_70101", "id": "reaction_10442109", "reactome": "R-DME-202969", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442103" ], "products": [ "species_10442105", "species_10442107" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "Q9XYF4", "FBgn0026404" ] }, "reaction_10441580": { "compartment": "compartment_876", "id": "reaction_10441580", "reactome": "R-DME-201595", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441575" ], "products": [ "species_10441577" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0260799", "FBgn0260799", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441641": { "compartment": "compartment_70101", "id": "reaction_10441641", "reactome": "R-DME-201636", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441637" ], "products": [ "species_10441639" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0013733", "FBgn0013733", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444136": { "compartment": "compartment_70101", "id": "reaction_10444136", "reactome": "R-DME-351876", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444130" ], "products": [ "species_10444132", "species_10444134" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0014037", "FBgn0014037", "FBgn0014037", "Q9XYF4", "FBgn0026404" ] }, "reaction_10442039": { "compartment": "compartment_876", "id": "reaction_10442039", "reactome": "R-DME-202939", "name": "Caspase-mediated cleavage of E-Cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442033" ], "products": [ "species_10442035", "species_10442037" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0262018", "FBgn0262018", "FBgn0262018", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441632": { "compartment": "compartment_70101", "id": "reaction_10441632", "reactome": "R-DME-201630", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441626" ], "products": [ "species_10441628", "species_10441630" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0263198", "FBgn0263198", "FBgn0263198", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444189": { "compartment": "compartment_70101", "id": "reaction_10444189", "reactome": "R-DME-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444185" ], "products": [ "species_10444187" ], "modifiers": [ [ "species_10444143", "catalyst" ] ], "additional_components": [ "FBgn0026479", "FBgn0026479", "FBgn0035165" ] }, "reaction_10444180": { "compartment": "compartment_13231", "id": "reaction_10444180", "reactome": "R-DME-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444154" ], "products": [ "species_10444178" ], "modifiers": [], "additional_components": [ "FBgn0266465", "FBgn0266465" ] }, "reaction_10443148": { "compartment": "compartment_13231", "id": "reaction_10443148", "reactome": "R-DME-211206", "name": "Translocation of DFF to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443134" ], "products": [ "species_10443146" ], "modifiers": [], "additional_components": [ "O18388", "FBgn0262743", "O76521", "FBgn0024889", "Q9V3H0", "FBgn0028406", "O18388", "FBgn0262743", "O76521", "FBgn0024889", "Q9V3H0", "FBgn0028406" ] }, "reaction_10443158": { "compartment": "compartment_13231", "id": "reaction_10443158", "reactome": "R-DME-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434841" ], "products": [ "species_10443156" ], "modifiers": [], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q9XYF4", "FBgn0026404" ] }, "reaction_10443126": { "compartment": "compartment_7660", "id": "reaction_10443126", "reactome": "R-DME-211193", "name": "Homodimerization of DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443122" ], "products": [ "species_10443124" ], "modifiers": [], "additional_components": [ "FBgn0028406", "Q9V3H0", "FBgn0028406" ] }, "reaction_10443924": { "compartment": "compartment_7660", "id": "reaction_10443924", "reactome": "R-DME-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443920", "species_29428" ], "products": [ "species_10443922" ], "modifiers": [], "additional_components": [ "Q24537", "Dsp1", "E1JIT5", "FBgn0038979", "Q9VCZ5", "FBgn0038978", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "E1JIT5", "FBgn0038979", "Q9VCZ5", "FBgn0038978", "Q05783", "FBgn0004362" ] }, "reaction_10444128": { "compartment": "compartment_70101", "id": "reaction_10444128", "reactome": "R-DME-351863", "name": "Translocation of active caspase-8 to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441655" ], "products": [ "species_10444126" ], "modifiers": [], "additional_components": [ "O01382", "FBgn0019972", "O01382", "FBgn0019972" ] }, "reaction_10444436": { "compartment": "compartment_70101", "id": "reaction_10444436", "reactome": "R-DME-373705", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444421" ], "products": [ "species_10444433", "species_10444427" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "Q9XYF4", "FBgn0026404" ] }, "reaction_10497776": { "compartment": "compartment_70101", "id": "reaction_10497776", "reactome": "R-DME-9627369", "name": "SEPT4 binds XIAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497772", "species_10434883" ], "products": [ "species_10497774" ], "modifiers": [], "additional_components": [ "Q0KHR7", "FBgn0259923", "Q24306", "Diap1", "Q24307", "Diap2", "Q0KHR7", "FBgn0259923", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10497768": { "compartment": "compartment_70101", "id": "reaction_10497768", "reactome": "R-DME-9627104", "name": "XIAP binds CASP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434883", "species_10434841" ], "products": [ "species_10497766" ], "modifiers": [], "additional_components": [ "Q24306", "Diap1", "Q24307", "Diap2", "Q9XYF4", "FBgn0026404", "Q9XYF4", "FBgn0026404", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10497770": { "compartment": "compartment_70101", "id": "reaction_10497770", "reactome": "R-DME-9627107", "name": "XIAP binds CASP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434883", "species_10434869" ], "products": [ "species_10434885" ], "modifiers": [], "additional_components": [ "Q24306", "Diap1", "Q24307", "Diap2", "Q9VET9", "FBgn0028381", "Q9VET9", "FBgn0028381", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10486228": { "compartment": "compartment_70101", "id": "reaction_10486228", "reactome": "R-DME-6805811", "name": "Release of SEPT4 from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486224" ], "products": [ "species_10486226" ], "modifiers": [], "additional_components": [ "FBgn0259923", "FBgn0259923" ] }, "reaction_10434873": { "compartment": "compartment_17906", "id": "reaction_10434873", "reactome": "R-DME-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434871" ], "products": [ "species_10434846" ], "modifiers": [], "additional_components": [ "FBgn0284248", "FBgn0284248" ] }, "reaction_10433151": { "compartment": "compartment_5460", "id": "reaction_10433151", "reactome": "R-DME-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433190": { "compartment": "compartment_5460", "id": "reaction_10433190", "reactome": "R-DME-77309", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77253" ], "products": [ "species_77308", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10468301": { "compartment": "compartment_7660", "id": "reaction_10468301", "reactome": "R-DME-3318415", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467826", "species_113560" ], "products": [ "species_2485002", "species_10468296" ], "modifiers": [ [ "species_10437332", "catalyst" ] ], "additional_components": [ "FBgn0001198", "FBgn0001198", "FBgn0265193" ] }, "reaction_10468772": { "compartment": "compartment_7660", "id": "reaction_10468772", "reactome": "R-DME-3662335", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468720", "species_113560" ], "products": [ "species_2485002", "species_10468769" ], "modifiers": [ [ "species_10458126", "catalyst" ] ], "additional_components": [ "FBgn0261617" ] }, "reaction_10472691": { "compartment": "compartment_7660", "id": "reaction_10472691", "reactome": "R-DME-5579018", "name": "NCOA1(868-1441) binds PAX3(1-319)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472670", "species_10472687" ], "products": [ "species_10472689" ], "modifiers": [], "additional_components": [ "FBgn0041092", "P09083", "FBgn0001147", "P09082", "FBgn0001148", "P06601", "FBgn0003145", "P09083", "FBgn0001147", "P09082", "FBgn0001148", "P06601", "FBgn0003145", "M9ND53", "FBgn0041092" ] }, "reaction_10441327": { "compartment": "compartment_70101", "id": "reaction_10441327", "reactome": "R-DME-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441315", "species_113592" ], "products": [ "species_29370", "species_10441322" ], "modifiers": [ [ "species_10441324", "catalyst" ] ], "additional_components": [ "A1Z784", "FBgn0033246", "species_266099", "A1Z784", "FBgn0033246", "species_266099", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357" ] }, "reaction_10436920": { "compartment": "compartment_876", "id": "reaction_10436920", "reactome": "R-DME-165026", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10436917", "catalyst" ] ], "additional_components": [ "Q9VCA0", "FBgn0039178", "Q9VNW8", "FBgn0037144", "Q961R9", "FBgn0038407", "Q9VEY1", "FBgn0038404", "A2RVG5", "FBgn0063649", "Q9VD40", "FBgn0038938", "Q9VNX2", "FBgn0037140" ] }, "reaction_10441335": { "compartment": "compartment_17927", "id": "reaction_10441335", "reactome": "R-DME-200424", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_201023", "species_201034" ], "products": [ "species_549207", "species_201050" ], "modifiers": [ [ "species_10441332", "catalyst" ] ], "additional_components": [ "FBgn0019830" ] }, "reaction_10441286": { "compartment": "compartment_70616", "id": "reaction_10441286", "reactome": "R-DME-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10441283", "catalyst" ] ], "additional_components": [ "FBgn0035383" ] }, "reaction_10490057": { "compartment": "compartment_70101", "id": "reaction_10490057", "reactome": "R-DME-8866941", "name": "MID1IP1 binds THRSP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432448", "species_10432446" ], "products": [ "species_10432450" ], "modifiers": [], "additional_components": [ "FBgn0035087", "FBgn0035087", "Q9W0X5", "FBgn0035087" ] }, "reaction_10432452": { "compartment": "compartment_70101", "id": "reaction_10432452", "reactome": "R-DME-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10432440", "catalyst" ], [ "species_10432450", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "species_266099", "A1Z784", "FBgn0033246", "Q9W0X5", "FBgn0035087" ] }, "reaction_10491438": { "compartment": "compartment_70101", "id": "reaction_10491438", "reactome": "R-DME-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10441315", "catalyst" ], [ "species_10432450", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "A1Z784", "FBgn0033246", "species_266099", "Q9W0X5", "FBgn0035087" ] }, "reaction_10465132": { "compartment": "compartment_70101", "id": "reaction_10465132", "reactome": "R-DME-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10429065", "catalyst" ] ], "additional_components": [ "species_1562550", "P46415", "FBgn0011768" ] }, "reaction_10465049": { "compartment": "compartment_70101", "id": "reaction_10465049", "reactome": "R-DME-2161195", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161194" ], "products": [ "species_2161176", "species_2161175" ], "modifiers": [ [ "species_10465044", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VHH7", "FBgn0037661" ] }, "reaction_10465129": { "compartment": "compartment_70101", "id": "reaction_10465129", "reactome": "R-DME-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10431536", "catalyst" ] ], "additional_components": [ "Q9VWV5", "FBgn0052549", "species_29926" ] }, "reaction_10469582": { "compartment": "compartment_70101", "id": "reaction_10469582", "reactome": "R-DME-4084989", "name": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_4085390" ], "products": [ "species_428633", "species_29372" ], "modifiers": [ [ "species_10469579", "catalyst" ] ], "additional_components": [ "species_29926", "Q9W481", "FBgn0029801" ] }, "reaction_10469572": { "compartment": "compartment_70101", "id": "reaction_10469572", "reactome": "R-DME-4084976", "name": "NANS converts ManNAc-6-P to Neu5Ac-9-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_4085225", "species_29492" ], "products": [ "species_29372", "species_4085390" ], "modifiers": [ [ "species_10469569", "catalyst" ] ], "additional_components": [ "FBgn0038045" ] }, "reaction_10469586": { "compartment": "compartment_20699", "id": "reaction_10469586", "reactome": "R-DME-4085033", "name": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_4086285" ], "products": [ "species_727810", "species_4086294" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "FBgn0035050" ] }, "reaction_10475581": { "compartment": "compartment_70101", "id": "reaction_10475581", "reactome": "R-DME-5668545", "name": "NIK autophosphorylates on T559", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10446829" ], "products": [ "species_29370", "species_10475579" ], "modifiers": [ [ "species_10446829", "catalyst" ] ], "additional_components": [ "FBgn0024329", "FBgn0024329", "FBgn0024329" ] }, "reaction_10433321": { "compartment": "compartment_7660", "id": "reaction_10433321", "reactome": "R-DME-83805", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433315", "species_10432757" ], "products": [ "species_10433319" ], "modifiers": [], "additional_components": [ "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463", "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512" ] }, "reaction_10433317": { "compartment": "compartment_7660", "id": "reaction_10433317", "reactome": "R-DME-83790", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432662", "species_10433311" ], "products": [ "species_10433315" ], "modifiers": [], "additional_components": [ "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512" ] }, "reaction_10433313": { "compartment": "compartment_7660", "id": "reaction_10433313", "reactome": "R-DME-83788", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432691", "species_83747" ], "products": [ "species_10433311" ], "modifiers": [], "additional_components": [ "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390" ] }, "reaction_10443033": { "compartment": "compartment_984", "id": "reaction_10443033", "reactome": "R-DME-210439", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382" ], "products": [ "species_29404" ], "modifiers": [ [ "species_10443030", "catalyst" ] ], "additional_components": [] }, "reaction_10428246": { "compartment": "compartment_70101", "id": "reaction_10428246", "reactome": "R-DME-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_31633" ], "products": [ "species_29372", "species_29370", "species_29472" ], "modifiers": [ [ "species_10428243", "catalyst" ] ], "additional_components": [ "P20478", "FBgn0001145", "P20477", "FBgn0001142" ] }, "reaction_10464591": { "compartment": "compartment_12045", "id": "reaction_10464591", "reactome": "R-DME-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10446277", "catalyst" ] ], "additional_components": [ "FBgn0039890" ] }, "reaction_10464593": { "compartment": "compartment_17957", "id": "reaction_10464593", "reactome": "R-DME-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10453288", "catalyst" ] ], "additional_components": [ "Q9VV87", "FBgn0260960", "Q9VHX7", "FBgn0037534", "Q6NN18", "FBgn0034382", "Q9VCY6", "FBgn0038986", "Q9VH59", "FBgn0037761", "Q4V3H4", "FBgn0037764", "Q9VCY5", "FBgn0053110", "Q9VH58", "FBgn0037762", "A1ZBD2", "FBgn0034383", "Q9VCT3", "FBgn0039030", "Q9VH57", "FBgn0037763", "Q95T98", "FBgn0051523", "Q9VH55", "FBgn0037765", "Q8SXD1", "FBgn0050008", "Q9VCZ0", "FBgn0038983", "Q8IMY2", "FBgn0051141", "Q9VCY7", "FBgn0260942" ] }, "reaction_214880": { "compartment": "compartment_70101", "id": "reaction_214880", "reactome": "R-DME-214880", "name": "DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "In dorsoventral patterning in the embryo, Dorsal (DL) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.", "reactants": [ "species_214746", "species_214759" ], "products": [ "species_214758" ], "modifiers": [], "additional_components": [ "P15330", "dl", "Q03017", "phospho-cact", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P15330", "dl", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214857": { "compartment": "compartment_70101", "id": "reaction_214857", "reactome": "R-DME-214857", "name": "DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "The Dorsal (DL) and Dorsal-related immunity factor (DIF) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.", "reactants": [ "species_206862", "species_206693" ], "products": [ "species_214744" ], "modifiers": [], "additional_components": [ "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL" ] }, "reaction_10467071": { "compartment": "compartment_70101", "id": "reaction_10467071", "reactome": "R-DME-2744361", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10467068", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9VUM6", "FBgn0036491", "Q9VRW4", "FBgn0035696", "Q9VUM7", "FBgn0036492" ] }, "reaction_10498689": { "compartment": "compartment_70101", "id": "reaction_10498689", "reactome": "R-DME-9701141", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10468206", "catalyst" ] ], "additional_components": [ "FBgn0086693" ] }, "reaction_10468221": { "compartment": "compartment_70101", "id": "reaction_10468221", "reactome": "R-DME-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10468218", "catalyst" ] ], "additional_components": [ "Q9VJJ7", "FBgn0032593", "Q9W3W0", "FBgn0086693", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "Q9VW35", "FBgn0261361", "Q7Z020", "FBgn0035934", "A8DYE2", "FBgn0265194" ] }, "reaction_10498686": { "compartment": "compartment_70101", "id": "reaction_10498686", "reactome": "R-DME-9701055", "name": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10498683", "catalyst" ] ], "additional_components": [ "Q7Z020", "FBgn0035934" ] }, "reaction_10498213": { "compartment": "compartment_876", "id": "reaction_10498213", "reactome": "R-DME-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10498211" ], "products": [ "species_10466252" ], "modifiers": [], "additional_components": [ "Q9VJI4", "FBgn0032602", "Q9VJI4", "FBgn0032602", "species_163953" ] }, "reaction_10466969": { "compartment": "compartment_70101", "id": "reaction_10466969", "reactome": "R-DME-2730959", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2730999", "species_70106" ], "products": [ "species_428040", "species_352022" ], "modifiers": [ [ "species_10466966", "catalyst" ] ], "additional_components": [ "Q7JZ25", "FBgn0033755", "Q95SH7", "FBgn0035440" ] }, "reaction_10466773": { "compartment": "compartment_70101", "id": "reaction_10466773", "reactome": "R-DME-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10466770", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "M9PI24", "FBgn0036235", "O97132", "FBgn0000152", "Q9V416", "FBgn0028879" ] }, "reaction_10466997": { "compartment": "compartment_70101", "id": "reaction_10466997", "reactome": "R-DME-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10466992", "catalyst" ] ], "additional_components": [ "FBgn0051116" ] }, "reaction_10466803": { "compartment": "compartment_70101", "id": "reaction_10466803", "reactome": "R-DME-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_74722", "species_352022" ], "modifiers": [ [ "species_10466798", "catalyst" ] ], "additional_components": [ "FBgn0036566" ] }, "reaction_10467123": { "compartment": "compartment_17927", "id": "reaction_10467123", "reactome": "R-DME-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_2889081" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10467120", "catalyst" ] ], "additional_components": [ "species_74113", "species_425810", "species_425810", "species_74113", "FBgn0031865" ] }, "reaction_10466257": { "compartment": "compartment_70101", "id": "reaction_10466257", "reactome": "R-DME-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10466252", "catalyst" ], [ "species_10466255", "inhibitor" ], [ "species_2672379", "inhibitor" ], [ "species_2672383", "inhibitor" ] ], "additional_components": [ "Q9VJI4", "FBgn0032602", "species_163953", "FBgn0032602" ] }, "reaction_10467025": { "compartment": "compartment_70101", "id": "reaction_10467025", "reactome": "R-DME-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10467022", "catalyst" ] ], "additional_components": [ "FBgn0015558" ] }, "reaction_10489584": { "compartment": "compartment_876", "id": "reaction_10489584", "reactome": "R-DME-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489580", "species_10466252" ], "products": [ "species_10489582" ], "modifiers": [], "additional_components": [ "Q9VZA4", "FBgn0260657", "Q9VJI4", "FBgn0032602", "species_163953", "Q9VJI4", "FBgn0032602", "species_163953", "Q9VZA4", "FBgn0260657" ] }, "reaction_10467118": { "compartment": "compartment_984", "id": "reaction_10467118", "reactome": "R-DME-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10467115", "catalyst" ] ], "additional_components": [ "FBgn0031865" ] }, "reaction_10467020": { "compartment": "compartment_70101", "id": "reaction_10467020", "reactome": "R-DME-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10467017", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9W5A5", "FBgn0261444", "Q9U6L4", "FBgn0015558" ] }, "reaction_10466793": { "compartment": "compartment_70101", "id": "reaction_10466793", "reactome": "R-DME-2730664", "name": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10466790", "catalyst" ], [ "species_74016", "inhibitor" ] ], "additional_components": [ "Q9VDY5", "FBgn0038693", "A8JUW5", "FBgn0002917", "Q9VB11", "FBgn0039536" ] }, "reaction_10467080": { "compartment": "compartment_70101", "id": "reaction_10467080", "reactome": "R-DME-2752067", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627" ], "products": [ "species_425425" ], "modifiers": [ [ "species_10467068", "catalyst" ] ], "additional_components": [ "Q9VUM6", "FBgn0036491", "Q9VRW4", "FBgn0035696", "Q9VUM7", "FBgn0036492" ] }, "reaction_10466592": { "compartment": "compartment_984", "id": "reaction_10466592", "reactome": "R-DME-2672334", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10466589", "catalyst" ], [ "species_2672379", "inhibitor" ] ], "additional_components": [ "Q9W2B5", "FBgn0085398", "Q9W250", "FBgn0034730", "Q9VZN1", "FBgn0035458", "Q9VS73", "FBgn0035785", "Q9VME9", "FBgn0031802", "Q9VME8", "FBgn0031803", "Q9VL88", "FBgn0265001", "Q9VL84", "FBgn0065109", "Q9VBF6", "FBgn0039424", "Q9VAJ7", "FBgn0039675", "Q9VAJ6", "FBgn0039676", "Q9VAJ5", "FBgn0039677", "Q9VAJ3", "FBgn0039679", "Q9V9Y5", "FBgn0039839", "Q8MLR6", "FBgn0050181", "Q8IMV2", "FBgn0051105", "Q86LH3", "FBgn0034489", "Q86LH1", "FBgn0065110", "Q86LG9", "FBgn0053508", "Q86LG7", "FBgn0065108", "Q86LG1", "FBgn0030795", "Q7KTW2", "FBgn0053289", "Q7KT94", "FBgn0020258", "Q0KHW3", "FBgn0052792", "O61365", "FBgn0024319", "A8JV41", "FBgn0030844", "A8JPJ8", "FBgn0051065", "A8DYP1", "FBgn0034965", "A1Z6S4", "FBgn0053349" ] }, "reaction_10489010": { "compartment": "compartment_17938", "id": "reaction_10489010", "reactome": "R-DME-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10488963" ], "products": [ "species_29372", "species_10489003" ], "modifiers": [ [ "species_10488963", "catalyst" ], [ "species_10489008", "catalyst" ] ], "additional_components": [ "O76742", "FBgn0015795", "species_29438", "O76742", "FBgn0015795", "species_29420", "O76742", "FBgn0015795", "species_29438", "FBgn0031233" ] }, "reaction_10488981": { "compartment": "compartment_262783", "id": "reaction_10488981", "reactome": "R-DME-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488970", "species_10488977" ], "products": [ "species_10488979" ], "modifiers": [], "additional_components": [ "FBgn0037917", "species_29438", "P40946", "FBgn0013750", "species_29438", "P40946", "FBgn0013750", "Q9VGL8", "FBgn0037917" ] }, "reaction_10488999": { "compartment": "compartment_20699", "id": "reaction_10488999", "reactome": "R-DME-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488142", "species_10488995" ], "products": [ "species_10488997" ], "modifiers": [], "additional_components": [ "O18334", "Rab6", "species_29438", "FBgn0035879", "A8JNN5", "FBgn0035879", "O18334", "Rab6", "species_29438" ] }, "reaction_10488968": { "compartment": "compartment_17938", "id": "reaction_10488968", "reactome": "R-DME-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10488963" ], "products": [ "species_29372", "species_10488965" ], "modifiers": [ [ "species_10488963", "catalyst" ] ], "additional_components": [ "O76742", "FBgn0015795", "species_29438", "O76742", "FBgn0015795", "species_29420", "O76742", "FBgn0015795", "species_29438" ] }, "reaction_10488924": { "compartment": "compartment_24339", "id": "reaction_10488924", "reactome": "R-DME-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10488901" ], "products": [ "species_29372", "species_10488903" ], "modifiers": [ [ "species_10488901", "catalyst" ], [ "species_10488922", "catalyst" ] ], "additional_components": [ "Q9W5X0", "FBgn0031090", "species_29438", "Q9W5X0", "FBgn0031090", "species_29420", "Q9W5X0", "FBgn0031090", "species_29438", "Q9VSM8", "FBgn0035916", "Q9VIH7", "FBgn0032901", "Q9VGL8", "FBgn0037917" ] }, "reaction_10488990": { "compartment": "compartment_70101", "id": "reaction_10488990", "reactome": "R-DME-8854302", "name": "TBC1D7 binds the TSC1-TSC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488986", "species_10436942" ], "products": [ "species_10488988" ], "modifiers": [], "additional_components": [ "FBgn0039158", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VCC4", "FBgn0039158" ] }, "reaction_10489038": { "compartment": "compartment_437051", "id": "reaction_10489038", "reactome": "R-DME-8854604", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10489028" ], "products": [ "species_29372", "species_10489030" ], "modifiers": [ [ "species_10489028", "catalyst" ], [ "species_10489036", "catalyst" ] ], "additional_components": [ "Q7KY04", "FBgn0016701", "species_29438", "Q7KY04", "FBgn0016701", "species_29420", "Q7KY04", "FBgn0016701", "species_29438", "FBgn0032249" ] }, "reaction_10489022": { "compartment": "compartment_5683628", "id": "reaction_10489022", "reactome": "R-DME-8854588", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489018", "species_10476330" ], "products": [ "species_10489020" ], "modifiers": [], "additional_components": [ "FBgn0034009", "FBgn0052672", "Q9W2S2", "FBgn0052672", "Q5BI03", "FBgn0034009" ] }, "reaction_10488959": { "compartment": "compartment_171062", "id": "reaction_10488959", "reactome": "R-DME-8854222", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488927", "species_10488955" ], "products": [ "species_10488957" ], "modifiers": [], "additional_components": [ "FBgn0020620", "species_29438", "Q9V3I2", "FBgn0014010", "Q9W329", "FBgn0030141", "Q9W0H9", "FBgn0262937", "species_29438", "Q9V3I2", "FBgn0014010", "Q9W329", "FBgn0030141", "Q9W0H9", "FBgn0262937", "A1Z9K4", "FBgn0020620" ] }, "reaction_10479983": { "compartment": "compartment_5460", "id": "reaction_10479983", "reactome": "R-DME-6788556", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436354", "species_10477522", "species_76629", "species_10436347" ], "products": [ "species_10477520", "species_10436356", "species_10436349" ], "modifiers": [], "additional_components": [ "FBgn0030853", "Q9V9M8", "FBgn0032986", "FBgn0031771", "FBgn0032986", "Q9VX36", "FBgn0030853", "Q9VMI3", "FBgn0031771", "species_76629" ] }, "reaction_10485760": { "compartment": "compartment_5460", "id": "reaction_10485760", "reactome": "R-DME-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436528", "species_10436547", "species_10484249", "species_10436554", "species_10436540" ], "products": [ "species_10484251" ], "modifiers": [], "additional_components": [ "Q9VPE2", "FBgn0037001", "species_113596", "Q9VXK7", "FBgn0030718", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VF27", "FBgn0017567", "FBgn0266582", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596" ] }, "reaction_10484318": { "compartment": "compartment_70616", "id": "reaction_10484318", "reactome": "R-DME-6799191", "name": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484277", "species_10436408", "species_10484282", "species_10484270" ], "products": [ "species_10484284" ], "modifiers": [], "additional_components": [ "FBgn0033891", "FBgn0013679", "FBgn0030352", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891" ] }, "reaction_10479981": { "compartment": "compartment_5460", "id": "reaction_10479981", "reactome": "R-DME-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477522", "species_10479977" ], "products": [ "species_10477520", "species_10479979" ], "modifiers": [], "additional_components": [ "Q9V9M8", "FBgn0032986", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q94511", "FBgn0017566", "Q9VXK7", "FBgn0030718", "FBgn0032986", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q94511", "FBgn0017566", "Q9VXK7", "FBgn0030718" ] }, "reaction_10484328": { "compartment": "compartment_5460", "id": "reaction_10484328", "reactome": "R-DME-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484256", "species_10484261", "species_10484266", "species_10484251" ], "products": [ "species_10484268" ], "modifiers": [], "additional_components": [ "FBgn0034919", "FBgn0037777", "FBgn0010340", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919" ] }, "reaction_10484326": { "compartment": "compartment_70616", "id": "reaction_10484326", "reactome": "R-DME-6799202", "name": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484305", "species_10484284" ], "products": [ "species_10484307" ], "modifiers": [], "additional_components": [ "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681" ] }, "reaction_10477524": { "compartment": "compartment_5460", "id": "reaction_10477524", "reactome": "R-DME-5690023", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477520", "species_169274" ], "products": [ "species_10477522" ], "modifiers": [], "additional_components": [ "FBgn0032986", "Q9V9M8", "FBgn0032986" ] }, "reaction_10484324": { "compartment": "compartment_70616", "id": "reaction_10484324", "reactome": "R-DME-6799197", "name": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436370", "species_10484307", "species_10436365" ], "products": [ "species_10484309" ], "modifiers": [], "additional_components": [ "FBgn0013684", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "FBgn0262952", "P18931", "FBgn0262952", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "P18932", "FBgn0013684" ] }, "reaction_10484322": { "compartment": "compartment_70616", "id": "reaction_10484322", "reactome": "R-DME-6799196", "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484320" ], "products": [ "species_10484256", "species_10484277", "species_10484261", "species_10436566", "species_10484247", "species_10484266", "species_10484282", "species_10484314", "species_10484303" ], "modifiers": [], "additional_components": [ "Q9VMU0", "FBgn0031684", "Q9VMI3", "FBgn0031771", "species_76629", "Q9VWI0", "FBgn0031021", "M9NEW0", "FBgn0263051", "Q94511", "FBgn0017566", "Q9VQD7", "FBgn0031436", "Q9VX36", "FBgn0030853", "P18931", "FBgn0262952", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "P18932", "FBgn0013684", "FBgn0034919", "FBgn0033891", "FBgn0037777", "Q9VMU0", "FBgn0031684", "Q9VMI3", "FBgn0031771", "species_76629", "Q9VWI0", "FBgn0031021", "Q94511", "FBgn0017566", "Q9VQD7", "FBgn0031436", "Q9VX36", "FBgn0030853", "P18931", "FBgn0262952", "P18932", "FBgn0013684", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "P18929", "FBgn0013679", "FBgn0037880", "FBgn0010340", "FBgn0030352", "FBgn0263051", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436" ] }, "reaction_10484272": { "compartment": "compartment_70616", "id": "reaction_10484272", "reactome": "R-DME-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436521", "species_10484268" ], "products": [ "species_10484270" ], "modifiers": [], "additional_components": [ "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "species_113596", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967" ] }, "reaction_10492180": { "compartment": "compartment_70101", "id": "reaction_10492180", "reactome": "R-DME-8936851", "name": "AHRR binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492174", "species_10458122" ], "products": [ "species_10492178" ], "modifiers": [], "additional_components": [ "FBgn0003513", "FBgn0264075", "O15945", "FBgn0264075", "E1JIM6", "FBgn0003513" ] }, "reaction_10492214": { "compartment": "compartment_70101", "id": "reaction_10492214", "reactome": "R-DME-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492170" ], "products": [ "species_10492212" ], "modifiers": [], "additional_components": [ "E1JIM6", "FBgn0003513", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_8936852", "Q9VH95", "FBgn0037728", "P02828", "FBgn0001233", "E1JIM6", "FBgn0003513", "species_8936852" ] }, "reaction_10492172": { "compartment": "compartment_70101", "id": "reaction_10492172", "reactome": "R-DME-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10492168" ], "products": [ "species_10492170" ], "modifiers": [], "additional_components": [ "E1JIM6", "FBgn0003513", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "E1JIM6", "FBgn0003513", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_8936852" ] }, "reaction_10492220": { "compartment": "compartment_7660", "id": "reaction_10492220", "reactome": "R-DME-8937177", "name": "AHR:TCDD binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492216", "species_10458122" ], "products": [ "species_10492218" ], "modifiers": [], "additional_components": [ "species_8936852", "E1JIM6", "FBgn0003513", "FBgn0264075", "O15945", "FBgn0264075", "species_8936852", "E1JIM6", "FBgn0003513" ] }, "reaction_10426932": { "compartment": "compartment_7660", "id": "reaction_10426932", "reactome": "R-DME-68637", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10426924" ], "modifiers": [ [ "species_10426928", "catalyst" ] ], "additional_components": [ "FBgn0035918" ] }, "reaction_10426946": { "compartment": "compartment_7660", "id": "reaction_10426946", "reactome": "R-DME-68688", "name": "CDC6 association with ORC:origin complexes mediated by MCM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426924", "species_10426942" ], "products": [ "species_10426944" ], "modifiers": [], "additional_components": [ "FBgn0035918", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918" ] }, "reaction_10436878": { "compartment": "compartment_5460", "id": "reaction_10436878", "reactome": "R-DME-164834", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436872", "species_163953" ], "products": [ "species_10436868", "species_113529", "species_113593" ], "modifiers": [ [ "species_10436872", "catalyst" ] ], "additional_components": [ "species_113592", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_113592", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081" ] }, "reaction_10436875": { "compartment": "compartment_5460", "id": "reaction_10436875", "reactome": "R-DME-164832", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436870" ], "products": [ "species_10436872", "species_113521" ], "modifiers": [ [ "species_10436870", "catalyst" ] ], "additional_components": [ "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_29370", "species_29372", "species_113592", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_29370", "species_29372" ] }, "reaction_10436880": { "compartment": "compartment_5460", "id": "reaction_10436880", "reactome": "R-DME-164840", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_10436868" ], "products": [ "species_10436870" ], "modifiers": [], "additional_components": [ "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_29370", "species_29372" ] }, "reaction_10442136": { "compartment": "compartment_70101", "id": "reaction_10442136", "reactome": "R-DME-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442132", "species_10441803" ], "products": [ "species_10442134" ], "modifiers": [], "additional_components": [ "FBgn0030915", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VWV8", "FBgn0030915" ] }, "reaction_10442216": { "compartment": "compartment_876", "id": "reaction_10442216", "reactome": "R-DME-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442134" ], "products": [ "species_10442214" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VWV8", "FBgn0030915", "Q9VWV8", "FBgn0030915", "species_71185", "species_1562550", "species_76629", "species_113596", "species_29870", "Q27571", "FBgn0011676" ] }, "reaction_10442198": { "compartment": "compartment_70101", "id": "reaction_10442198", "reactome": "R-DME-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10442196" ], "products": [ "species_10441862" ], "modifiers": [], "additional_components": [ "FBgn0011676", "FBgn0011676" ] }, "reaction_10442194": { "compartment": "compartment_20699", "id": "reaction_10442194", "reactome": "R-DME-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441862", "species_200993" ], "products": [ "species_10442144" ], "modifiers": [ [ "species_10442191", "catalyst" ] ], "additional_components": [ "FBgn0011676", "FBgn0011676", "Q9I7L7", "FBgn0042133", "Q9VBM6", "FBgn0039368", "Q9W251", "FBgn0034729", "Q8IQN9", "FBgn0036670", "Q9VBM5", "FBgn0039369", "Q9VBM8", "FBgn0039366", "Q0IGS7", "FBgn0033815", "Q9VBM4", "FBgn0039370", "Q9VBM7", "FBgn0039367" ] }, "reaction_10441870": { "compartment": "compartment_20699", "id": "reaction_10441870", "reactome": "R-DME-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441864" ], "products": [ "species_10441868" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870" ] }, "reaction_10442218": { "compartment": "compartment_20699", "id": "reaction_10442218", "reactome": "R-DME-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442144" ], "products": [ "species_10441803" ], "modifiers": [], "additional_components": [ "FBgn0011676", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596" ] }, "reaction_10459882": { "compartment": "compartment_70101", "id": "reaction_10459882", "reactome": "R-DME-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_1222424", "species_29366" ], "modifiers": [ [ "species_10459877", "catalyst" ] ], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "species_1497857", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10478081": { "compartment": "compartment_876", "id": "reaction_10478081", "reactome": "R-DME-5693373", "name": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5693375" ], "products": [ "species_5693410", "species_29968" ], "modifiers": [ [ "species_10478076", "catalyst" ] ], "additional_components": [ "FBgn0030467" ] }, "reaction_10442208": { "compartment": "compartment_876", "id": "reaction_10442208", "reactome": "R-DME-203613", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441803" ], "products": [ "species_76168", "species_10441864" ], "modifiers": [ [ "species_10442205", "catalyst" ] ], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "M9PEW1", "FBgn0042138" ] }, "reaction_10434767": { "compartment": "compartment_7660", "id": "reaction_10434767", "reactome": "R-DME-112379", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434753", "species_10434721", "species_10434758", "species_10431174", "species_10434681", "species_10434698", "species_10434763", "species_10434686" ], "products": [ "species_10434765" ], "modifiers": [], "additional_components": [ "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "FBgn0030738", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q7JRJ1", "FBgn0033166", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "FBgn0028982", "FBgn0010422", "P20232", "FBgn0010422", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q7JRJ1", "FBgn0033166", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "A8JV07", "FBgn0030738", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637" ] }, "reaction_10475420": { "compartment": "compartment_70101", "id": "reaction_10475420", "reactome": "R-DME-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661268", "species_29360" ], "products": [ "species_70106", "species_5661262", "species_73473" ], "modifiers": [ [ "species_10475417", "catalyst" ] ], "additional_components": [ "Q9VXI1", "FBgn0286508" ] }, "reaction_10475402": { "compartment": "compartment_70101", "id": "reaction_10475402", "reactome": "R-DME-5661240", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5660036" ], "products": [ "species_5660033", "species_29366" ], "modifiers": [ [ "species_10475399", "catalyst" ] ], "additional_components": [ "Q9VWP2", "FBgn0030968" ] }, "reaction_10475431": { "compartment": "compartment_70101", "id": "reaction_10475431", "reactome": "R-DME-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_5661281", "species_73473" ], "modifiers": [ [ "species_10474621", "catalyst" ] ], "additional_components": [ "species_1562550", "O96299", "FBgn0022359" ] }, "reaction_10475428": { "compartment": "compartment_70101", "id": "reaction_10475428", "reactome": "R-DME-5662466", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5661281" ], "products": [ "species_29790", "species_29370" ], "modifiers": [ [ "species_10475425", "catalyst" ] ], "additional_components": [ "FBgn0038463" ] }, "reaction_10475410": { "compartment": "compartment_70101", "id": "reaction_10475410", "reactome": "R-DME-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10475407", "catalyst" ] ], "additional_components": [ "FBgn0035476" ] }, "reaction_10454299": { "compartment": "compartment_5460", "id": "reaction_10454299", "reactome": "R-DME-880033", "name": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_880041" ], "products": [ "species_880046", "species_879997" ], "modifiers": [ [ "species_10454286", "catalyst" ] ], "additional_components": [ "FBgn0017482" ] }, "reaction_10454297": { "compartment": "compartment_5460", "id": "reaction_10454297", "reactome": "R-DME-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10454294", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_880067", "catalyst" ], [ "species_113527", "catalyst" ] ], "additional_components": [ "FBgn0023507" ] }, "reaction_10454307": { "compartment": "compartment_70616", "id": "reaction_10454307", "reactome": "R-DME-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10454304", "catalyst" ] ], "additional_components": [ "FBgn0032729" ] }, "reaction_10479469": { "compartment": "compartment_70101", "id": "reaction_10479469", "reactome": "R-DME-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10479466", "catalyst" ] ], "additional_components": [ "species_1562550", "Q8IPU3", "FBgn0037024" ] }, "reaction_10496099": { "compartment": "compartment_5460", "id": "reaction_10496099", "reactome": "R-DME-9011543", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442340", "species_9010792" ], "products": [ "species_10442347" ], "modifiers": [], "additional_components": [ "FBgn0017558", "P91622", "FBgn0017558" ] }, "reaction_10442392": { "compartment": "compartment_5460", "id": "reaction_10442392", "reactome": "R-DME-204169", "name": "PDP dephosphorylates p-lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442333", "species_113521" ], "products": [ "species_10428865", "species_113548" ], "modifiers": [ [ "species_10442389", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q9VM14", "FBgn0283658", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "species_113596", "Q9VVL7", "FBgn0036762", "Q9VM14", "FBgn0283658", "species_113596", "Q9VVL7", "FBgn0036762", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "Q9W4K8", "FBgn0029706", "species_113596", "Q9W3Q1", "FBgn0029958" ] }, "reaction_10496106": { "compartment": "compartment_5460", "id": "reaction_10496106", "reactome": "R-DME-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_904849", "species_3301973" ], "modifiers": [ [ "species_10496103", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "Q9VHD2", "FBgn0037697", "species_29450" ] }, "reaction_10496180": { "compartment": "compartment_70101", "id": "reaction_10496180", "reactome": "R-DME-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_113528", "species_29398", "species_29364" ], "modifiers": [ [ "species_10496177", "catalyst" ] ], "additional_components": [ "species_29926", "Q86NT5", "FBgn0029154", "A1ZAF6", "FBgn0029153", "Q9VG31", "FBgn0002719", "E1JIZ4", "FBgn0029155", "Q7K3R0", "FBgn0034127" ] }, "reaction_10486326": { "compartment": "compartment_5460", "id": "reaction_10486326", "reactome": "R-DME-6807826", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113557", "species_29362" ], "products": [ "species_113526", "species_6807616" ], "modifiers": [ [ "species_10486323", "catalyst" ] ], "additional_components": [ "Q95028", "FBgn0001258", "A1Z9F8", "FBgn0033856" ] }, "reaction_10428151": { "compartment": "compartment_70101", "id": "reaction_10428151", "reactome": "R-DME-70510", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_29360" ], "products": [ "species_70106", "species_29398", "species_73473" ], "modifiers": [ [ "species_10428148", "catalyst" ] ], "additional_components": [ "A1Z9F8", "FBgn0033856", "Q95028", "FBgn0001258" ] }, "reaction_10496232": { "compartment": "compartment_70101", "id": "reaction_10496232", "reactome": "R-DME-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10470842", "catalyst" ] ], "additional_components": [ "Q9VKP4", "FBgn0260453", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q94920", "FBgn0004363" ] }, "reaction_10428868": { "compartment": "compartment_5460", "id": "reaction_10428868", "reactome": "R-DME-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_113557" ], "products": [ "species_113559", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428865", "catalyst" ] ], "additional_components": [ "Q9VM14", "FBgn0283658", "species_113596", "Q9VVL7", "FBgn0036762", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325" ] }, "reaction_10429155": { "compartment": "compartment_70101", "id": "reaction_10429155", "reactome": "R-DME-71849", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29398", "species_73473" ], "products": [ "species_29708", "species_29360" ], "modifiers": [ [ "species_10428148", "catalyst" ] ], "additional_components": [ "A1Z9F8", "FBgn0033856", "Q95028", "FBgn0001258" ] }, "reaction_10478225": { "compartment": "compartment_70101", "id": "reaction_10478225", "reactome": "R-DME-5694071", "name": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694074", "species_29450" ], "products": [ "species_5694130" ], "modifiers": [ [ "species_10478222", "catalyst" ] ], "additional_components": [ "species_1562550", "A1Z6X6", "FBgn0283450" ] }, "reaction_10496229": { "compartment": "compartment_5460", "id": "reaction_10496229", "reactome": "R-DME-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113529", "species_113557", "species_113600", "species_29376" ], "modifiers": [ [ "species_10496226", "catalyst" ] ], "additional_components": [ "species_29926", "E1JIZ4", "FBgn0029155" ] }, "reaction_10428534": { "compartment": "compartment_5460", "id": "reaction_10428534", "reactome": "R-DME-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10428531", "catalyst" ] ], "additional_components": [ "Q9W401", "FBgn0261955" ] }, "reaction_10428598": { "compartment": "compartment_5460", "id": "reaction_10428598", "reactome": "R-DME-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113581" ], "products": [ "species_29374", "species_113593", "species_113536" ], "modifiers": [ [ "species_10428595", "catalyst" ] ], "additional_components": [ "Q94522", "FBgn0004888", "Q95U38", "FBgn0037643" ] }, "reaction_10496201": { "compartment": "compartment_5460", "id": "reaction_10496201", "reactome": "R-DME-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_113557", "species_29362", "species_29376" ], "modifiers": [ [ "species_10496198", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "A1ZAF6", "FBgn0029153", "E1JIZ4", "FBgn0029155", "Q7K3R0", "FBgn0034127", "Q86NT5", "FBgn0029154", "Q9VG31", "FBgn0002719", "species_29926" ] }, "reaction_10496144": { "compartment": "compartment_5460", "id": "reaction_10496144", "reactome": "R-DME-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10496141", "catalyst" ] ], "additional_components": [ "Q9VDE2", "FBgn0038858", "species_29926" ] }, "reaction_10428524": { "compartment": "compartment_5460", "id": "reaction_10428524", "reactome": "R-DME-70971", "name": "citrate <=> isocitrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654" ], "products": [ "species_29938" ], "modifiers": [ [ "species_10428521", "catalyst" ] ], "additional_components": [ "FBgn0010100" ] }, "reaction_10451212": { "compartment": "compartment_5460", "id": "reaction_10451212", "reactome": "R-DME-451033", "name": "(S)-Malate <=> Fumarate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544" ], "products": [ "species_113588", "species_113521" ], "modifiers": [ [ "species_10428551", "catalyst" ] ], "additional_components": [ "Q9W3X6", "FBgn0286222" ] }, "reaction_10428583": { "compartment": "compartment_5460", "id": "reaction_10428583", "reactome": "R-DME-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10428580", "catalyst" ] ], "additional_components": [ "Q9VGS3", "FBgn0037873", "P21914", "FBgn0014028", "Q9VCI5", "FBgn0039112", "Q94523", "FBgn0261439", "species_113596" ] }, "reaction_10428870": { "compartment": "compartment_5460", "id": "reaction_10428870", "reactome": "R-DME-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_70958", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428624", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "species_8878387", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10428516": { "compartment": "compartment_5460", "id": "reaction_10428516", "reactome": "R-DME-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_29938" ], "products": [ "species_113594", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428513", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q8MT18", "FBgn0039358", "Q9VD58", "FBgn0038922", "species_266099", "Q9VWH4", "FBgn0027291" ] }, "reaction_10429124": { "compartment": "compartment_5460", "id": "reaction_10429124", "reactome": "R-DME-71783", "name": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_29362", "species_113587" ], "products": [ "species_113544", "species_113526" ], "modifiers": [ [ "species_10428541", "catalyst" ] ], "additional_components": [ "Q9VEB1", "FBgn0262559" ] }, "reaction_10429122": { "compartment": "compartment_5460", "id": "reaction_10429122", "reactome": "R-DME-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113525" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10429119", "catalyst" ] ], "additional_components": [ "Q9V470", "FBgn0029118", "Q94522", "FBgn0004888" ] }, "reaction_10487120": { "compartment": "compartment_20699", "id": "reaction_10487120", "reactome": "R-DME-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487116", "species_10486635" ], "products": [ "species_10487118" ], "modifiers": [], "additional_components": [ "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q7JY00", "FBgn0037084", "Q9W0N6", "FBgn0260862", "Q9W1I8", "FBgn0034913", "Q9VHB5", "FBgn0261049", "Q9VR90", "FBgn0031106", "Q9VE50", "FBgn0044871", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q7JY00", "FBgn0037084", "Q9W0N6", "FBgn0260862", "Q9W1I8", "FBgn0034913", "Q9VHB5", "FBgn0261049", "Q9VR90", "FBgn0031106", "Q9VE50", "FBgn0044871" ] }, "reaction_10487796": { "compartment": "compartment_20699", "id": "reaction_10487796", "reactome": "R-DME-8847875", "name": "ARF1:GTP binds Golgin TRIP11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461046", "species_10487792" ], "products": [ "species_10487794" ], "modifiers": [], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "A0A4D6K5M0", "FBgn0027287", "A0A4D6K5M0", "FBgn0027287", "P61209", "FBgn0010348", "species_29438" ] }, "reaction_10488246": { "compartment": "compartment_20699", "id": "reaction_10488246", "reactome": "R-DME-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486635", "species_10488242" ], "products": [ "species_10488244" ], "modifiers": [], "additional_components": [ "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "species_29438", "O18334", "Rab6", "Q9W0A7", "FBgn0035255", "Q9W3Q0", "FBgn0029959", "Q9VM50", "FBgn0031882", "species_29438", "O18334", "Rab6", "Q9W0A7", "FBgn0035255", "Q9W3Q0", "FBgn0029959", "Q9VM50", "FBgn0031882", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401" ] }, "reaction_10487719": { "compartment": "compartment_20699", "id": "reaction_10487719", "reactome": "R-DME-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10478727", "species_10487715" ], "products": [ "species_10487717" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9W3M8", "FBgn0260858", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9W3M8", "FBgn0260858", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487815": { "compartment": "compartment_20699", "id": "reaction_10487815", "reactome": "R-DME-8847880", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461046", "species_10487801" ], "products": [ "species_10487813" ], "modifiers": [], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "FBgn0086779", "P61209", "FBgn0010348", "species_29438", "Q0E8N2", "FBgn0086779" ] }, "reaction_10487822": { "compartment": "compartment_20699", "id": "reaction_10487822", "reactome": "R-DME-8847883", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487813" ], "products": [ "species_10487819" ], "modifiers": [ [ "species_10487813", "catalyst" ] ], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "Q0E8N2", "FBgn0086779", "P61209", "FBgn0010348", "species_29420", "Q0E8N2", "FBgn0086779", "P61209", "FBgn0010348", "species_29438", "Q0E8N2", "FBgn0086779" ] }, "reaction_10474701": { "compartment": "compartment_17963", "id": "reaction_10474701", "reactome": "R-DME-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10474698", "catalyst" ] ], "additional_components": [ "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047" ] }, "reaction_10474773": { "compartment": "compartment_17963", "id": "reaction_10474773", "reactome": "R-DME-5653878", "name": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_964746" ], "products": [ "species_5653871", "species_205687" ], "modifiers": [ [ "species_10474770", "catalyst" ] ], "additional_components": [ "Q7KN92", "FBgn0027538", "P83972", "FBgn0004427", "A1ZBX6", "FBgn0034538", "P83971", "FBgn0004426", "A1ZAB8", "FBgn0034092", "P37161", "FBgn0004431", "A1Z9D5", "FBgn0050062", "P37160", "FBgn0004430", "Q9W4C2", "FBgn0029765", "P37159", "FBgn0004428", "Q9VSA5", "FBgn0035813", "P29615", "FBgn0004429", "Q08694", "FBgn0004425", "A1ZBX7", "FBgn0034539" ] }, "reaction_10474803": { "compartment": "compartment_17963", "id": "reaction_10474803", "reactome": "R-DME-5653886", "name": "B4GALT1 binds LALBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474801", "species_10455850" ], "products": [ "species_10474770" ], "modifiers": [ [ "species_735682", "catalyst" ], [ "species_5653875", "catalyst" ] ], "additional_components": [ "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "FBgn0027538", "Q7KN92", "FBgn0027538", "P83972", "FBgn0004427", "A1ZBX6", "FBgn0034538", "P83971", "FBgn0004426", "A1ZAB8", "FBgn0034092", "P37161", "FBgn0004431", "A1Z9D5", "FBgn0050062", "P37160", "FBgn0004430", "Q9W4C2", "FBgn0029765", "P37159", "FBgn0004428", "Q9VSA5", "FBgn0035813", "P29615", "FBgn0004429", "Q08694", "FBgn0004425", "A1ZBX7", "FBgn0034539" ] }, "reaction_10431982": { "compartment": "compartment_7660", "id": "reaction_10431982", "reactome": "R-DME-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10431972" ], "products": [ "species_113582", "species_10431980" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0261278" ] }, "reaction_10427788": { "compartment": "compartment_7660", "id": "reaction_10427788", "reactome": "R-DME-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427741" ], "products": [ "species_113582", "species_10427778" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "FBgn0261278" ] }, "reaction_10438571": { "compartment": "compartment_7660", "id": "reaction_10438571", "reactome": "R-DME-176250", "name": "Binding of ATR-ATRIP to the RPA-ssDNA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438544", "species_10438562" ], "products": [ "species_10438569" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438567": { "compartment": "compartment_7660", "id": "reaction_10438567", "reactome": "R-DME-176175", "name": "Stalling of DNA replication fork and RPA binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_176104" ], "products": [ "species_10438544" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438548": { "compartment": "compartment_7660", "id": "reaction_10438548", "reactome": "R-DME-176101", "name": "Recruitment of Rad17-RFC complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438544", "species_10438542" ], "products": [ "species_10438546" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438612": { "compartment": "compartment_7660", "id": "reaction_10438612", "reactome": "R-DME-176318", "name": "Loading of claspin onto DNA during replication origin firing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427361", "species_10438600" ], "products": [ "species_10438602" ], "modifiers": [], "additional_components": [ "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "FBgn0052251", "Q8IRB5", "FBgn0052251", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10438595": { "compartment": "compartment_7660", "id": "reaction_10438595", "reactome": "R-DME-176264", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438546", "species_10438590" ], "products": [ "species_10438592" ], "modifiers": [ [ "species_10438546", "catalyst" ] ], "additional_components": [ "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VQD4", "FBgn0026778", "Q9VN60", "FBgn0026417", "A8JNV5", "FBgn0025807", "Q9VQD4", "FBgn0026778", "Q9VN60", "FBgn0026417", "A8JNV5", "FBgn0025807", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438610": { "compartment": "compartment_7660", "id": "reaction_10438610", "reactome": "R-DME-176298", "name": "Activation of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438602" ], "products": [ "species_10438608", "species_113582" ], "modifiers": [ [ "species_10438562", "catalyst" ] ], "additional_components": [ "Q8IRB5", "FBgn0052251", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "Q8IRB5", "FBgn0052251", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367" ] }, "reaction_209322": { "compartment": "compartment_7660", "id": "reaction_209322", "reactome": "R-DME-209322", "name": "In the absence of ARM, GRO binds to PAN and inhibits transcription", "reversible": "false", "notes": "In the absence of Armadillo (ARM) due to an active 'destruction complex' removing it in the cytoplasm, the protein Groucho (GRO) binds to Pangolin (PAN) and inhibits transcription.", "reactants": [ "species_205750", "species_205730" ], "products": [ "species_206798" ], "modifiers": [], "additional_components": [ "P91943", "PAN", "P16371", "GRO" ] }, "reaction_10464863": { "compartment": "compartment_161320", "id": "reaction_10464863", "reactome": "R-DME-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10460515", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10462796": { "compartment": "compartment_984", "id": "reaction_10462796", "reactome": "R-DME-2022056", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462724", "species_10462750" ], "products": [ "species_10462776", "species_10462794" ], "modifiers": [], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872" ] }, "reaction_10461387": { "compartment": "compartment_161320", "id": "reaction_10461387", "reactome": "R-DME-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105025" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10461298", "catalyst" ] ], "additional_components": [ "FBgn0032343" ] }, "reaction_10497909": { "compartment": "compartment_161320", "id": "reaction_10497909", "reactome": "R-DME-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10460517", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10461385": { "compartment": "compartment_161320", "id": "reaction_10461385", "reactome": "R-DME-1793182", "name": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065213" ], "products": [ "species_2065269", "species_1606845" ], "modifiers": [ [ "species_10461225", "catalyst" ] ], "additional_components": [ "Q9VZP8", "FBgn0035445", "species_74016" ] }, "reaction_10458176": { "compartment": "compartment_70101", "id": "reaction_10458176", "reactome": "R-DME-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_8942986", "species_983036" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10497911": { "compartment": "compartment_161320", "id": "reaction_10497911", "reactome": "R-DME-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10460517", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10465157": { "compartment": "compartment_161320", "id": "reaction_10465157", "reactome": "R-DME-2162227", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160866" ], "products": [ "species_2162223", "species_1678868" ], "modifiers": [ [ "species_10461348", "catalyst" ] ], "additional_components": [ "species_2162224", "A1ZBG9", "FBgn0034417" ] }, "reaction_10465155": { "compartment": "compartment_161320", "id": "reaction_10465155", "reactome": "R-DME-2162226", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2162224" ], "products": [ "species_1678743", "species_1678868" ], "modifiers": [ [ "species_10461348", "catalyst" ] ], "additional_components": [ "A1ZBG9", "FBgn0034417" ] }, "reaction_10465153": { "compartment": "compartment_161320", "id": "reaction_10465153", "reactome": "R-DME-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10460515", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10438422": { "compartment": "compartment_70101", "id": "reaction_10438422", "reactome": "R-DME-174392", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174375" ], "products": [ "species_111294", "species_174370" ], "modifiers": [ [ "species_10438414", "catalyst" ] ], "additional_components": [ "FBgn0020389" ] }, "reaction_10438419": { "compartment": "compartment_70101", "id": "reaction_10438419", "reactome": "R-DME-174389", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174370" ], "products": [ "species_29370", "species_158471" ], "modifiers": [ [ "species_10438414", "catalyst" ] ], "additional_components": [ "FBgn0020389" ] }, "reaction_10461983": { "compartment": "compartment_20699", "id": "reaction_10461983", "reactome": "R-DME-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10461911" ], "products": [ "species_10461945", "species_205687" ], "modifiers": [ [ "species_10461980", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "O97422", "FBgn0066114", "Q9VTG7", "FBgn0036144", "Q9VLA1", "FBgn0032135", "species_266099" ] }, "reaction_10497906": { "compartment": "compartment_20699", "id": "reaction_10497906", "reactome": "R-DME-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10461911" ], "products": [ "species_10461945", "species_205687" ], "modifiers": [ [ "species_10461978", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "O97422", "FBgn0066114", "species_266099" ] }, "reaction_10462025": { "compartment": "compartment_20699", "id": "reaction_10462025", "reactome": "R-DME-1889978", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462017", "species_735682" ], "products": [ "species_10461911", "species_205687" ], "modifiers": [ [ "species_10462022", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "FBgn0033315" ] }, "reaction_10461877": { "compartment": "compartment_20699", "id": "reaction_10461877", "reactome": "R-DME-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461833", "species_742361" ], "products": [ "species_10461867", "species_205687" ], "modifiers": [ [ "species_10461872", "catalyst" ] ], "additional_components": [ "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "FBgn0015360" ] }, "reaction_10462033": { "compartment": "compartment_20699", "id": "reaction_10462033", "reactome": "R-DME-1889981", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10461867" ], "products": [ "species_10462017", "species_205687" ], "modifiers": [ [ "species_10462030", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "FBgn0039258" ] }, "reaction_10462812": { "compartment": "compartment_20699", "id": "reaction_10462812", "reactome": "R-DME-2022061", "name": "Dermatan sulfate can be further sulfated on position 2 of iduronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10462684" ], "products": [ "species_742343", "species_10462804" ], "modifiers": [ [ "species_10462809", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "FBgn0003089" ] }, "reaction_10462828": { "compartment": "compartment_17963", "id": "reaction_10462828", "reactome": "R-DME-2022065", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462826" ], "products": [ "species_10462724" ], "modifiers": [], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872" ] }, "reaction_10462415": { "compartment": "compartment_20699", "id": "reaction_10462415", "reactome": "R-DME-1971483", "name": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10462365" ], "products": [ "species_742343", "species_10462375" ], "modifiers": [ [ "species_10462412", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VMS3", "FBgn0031697", "Q9VJG5", "FBgn0032618", "Q8IRG5", "FBgn0035287" ] }, "reaction_10463695": { "compartment": "compartment_17963", "id": "reaction_10463695", "reactome": "R-DME-2022911", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463693" ], "products": [ "species_10462750" ], "modifiers": [], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872" ] }, "reaction_10462445": { "compartment": "compartment_20699", "id": "reaction_10462445", "reactome": "R-DME-1971491", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10462345" ], "products": [ "species_10462425", "species_205687" ], "modifiers": [ [ "species_10462437", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VYH2", "FBgn0263005", "Q7KUZ9", "FBgn0030662" ] }, "reaction_10462440": { "compartment": "compartment_20699", "id": "reaction_10462440", "reactome": "R-DME-1971487", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10462425" ], "products": [ "species_205687", "species_10462365" ], "modifiers": [ [ "species_10462437", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VYH2", "FBgn0263005", "Q7KUZ9", "FBgn0030662" ] }, "reaction_10462355": { "compartment": "compartment_20699", "id": "reaction_10462355", "reactome": "R-DME-1971482", "name": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10462335" ], "products": [ "species_10462345", "species_205687" ], "modifiers": [ [ "species_10462350", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "FBgn0033500" ] }, "reaction_10497804": { "compartment": "compartment_20699", "id": "reaction_10497804", "reactome": "R-DME-9632033", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10462425" ], "products": [ "species_205687", "species_10462365" ], "modifiers": [ [ "species_10497801", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "FBgn0030662" ] }, "reaction_10497807": { "compartment": "compartment_20699", "id": "reaction_10497807", "reactome": "R-DME-9632034", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10462345" ], "products": [ "species_10462425", "species_205687" ], "modifiers": [ [ "species_10497801", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "FBgn0030662" ] }, "reaction_10462672": { "compartment": "compartment_20699", "id": "reaction_10462672", "reactome": "R-DME-2018682", "name": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10462365" ], "products": [ "species_742343", "species_10462649" ], "modifiers": [ [ "species_10462669", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VMC4", "FBgn0031826", "Q9VMC3", "FBgn0051637" ] }, "reaction_10461519": { "compartment": "compartment_70101", "id": "reaction_10461519", "reactome": "R-DME-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_870330" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10461516", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUW3", "FBgn0036553", "Q7KTW5", "FBgn0037063", "Q9VUW2", "FBgn0036553", "Q9VUW1", "FBgn0036550", "Q9VUW4", "FBgn0036553", "Q9VP62", "FBgn0037064" ] }, "reaction_10461647": { "compartment": "compartment_70101", "id": "reaction_10461647", "reactome": "R-DME-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629746" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10461723": { "compartment": "compartment_876", "id": "reaction_10461723", "reactome": "R-DME-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10461720", "catalyst" ] ], "additional_components": [ "O46094", "FBgn0023508", "B7Z0Q2", "FBgn0259178" ] }, "reaction_10461611": { "compartment": "compartment_70101", "id": "reaction_10461611", "reactome": "R-DME-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10461674": { "compartment": "compartment_70101", "id": "reaction_10461674", "reactome": "R-DME-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629753" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10461516", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUW3", "FBgn0036553", "Q7KTW5", "FBgn0037063", "Q9VUW2", "FBgn0036553", "Q9VUW1", "FBgn0036550", "Q9VUW4", "FBgn0036553", "Q9VP62", "FBgn0037064" ] }, "reaction_10476185": { "compartment": "compartment_70101", "id": "reaction_10476185", "reactome": "R-DME-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_426910" ], "products": [ "species_29356", "species_70106", "species_2162232" ], "modifiers": [ [ "species_10476182", "catalyst" ] ], "additional_components": [ "species_111793", "Q9VTU9", "FBgn0036262" ] }, "reaction_10461671": { "compartment": "compartment_70101", "id": "reaction_10461671", "reactome": "R-DME-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10461516", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUW3", "FBgn0036553", "Q7KTW5", "FBgn0037063", "Q9VUW2", "FBgn0036553", "Q9VUW1", "FBgn0036550", "Q9VUW4", "FBgn0036553", "Q9VP62", "FBgn0037064" ] }, "reaction_10461572": { "compartment": "compartment_70101", "id": "reaction_10461572", "reactome": "R-DME-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10461569", "catalyst" ] ], "additional_components": [ "M9PHS8", "FBgn0030761", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10461668": { "compartment": "compartment_70101", "id": "reaction_10461668", "reactome": "R-DME-1855208", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629739" ], "products": [ "species_29372", "species_1629753" ], "modifiers": [ [ "species_10461665", "catalyst" ] ], "additional_components": [ "Q9VFP6", "FBgn0016672", "species_29926" ] }, "reaction_10461603": { "compartment": "compartment_70101", "id": "reaction_10461603", "reactome": "R-DME-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10461600", "catalyst" ] ], "additional_components": [ "species_427523", "O97477", "FBgn0025885" ] }, "reaction_10461744": { "compartment": "compartment_70101", "id": "reaction_10461744", "reactome": "R-DME-1855232", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629746" ], "modifiers": [ [ "species_10461665", "catalyst" ] ], "additional_components": [ "Q9VFP6", "FBgn0016672", "species_29926" ] }, "reaction_10435903": { "compartment": "compartment_13959", "id": "reaction_10435903", "reactome": "R-DME-159783", "name": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435829" ], "products": [ "species_10435901" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10435817": { "compartment": "compartment_13959", "id": "reaction_10435817", "reactome": "R-DME-159757", "name": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435815" ], "products": [ "species_10435779" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10436713": { "compartment": "compartment_13959", "id": "reaction_10436713", "reactome": "R-DME-163825", "name": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436709" ], "products": [ "species_10436663" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459" ] }, "reaction_10436697": { "compartment": "compartment_13959", "id": "reaction_10436697", "reactome": "R-DME-163809", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436693" ], "products": [ "species_10436695" ], "modifiers": [], "additional_components": [ "FBgn0027594", "FBgn0027594" ] }, "reaction_10435879": { "compartment": "compartment_13959", "id": "reaction_10435879", "reactome": "R-DME-159762", "name": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435863" ], "products": [ "species_10435877" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10435972": { "compartment": "compartment_13959", "id": "reaction_10435972", "reactome": "R-DME-159836", "name": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435958" ], "products": [ "species_10435932" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10473803": { "compartment": "compartment_876", "id": "reaction_10473803", "reactome": "R-DME-5624126", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473254", "species_10473799", "species_10473785" ], "products": [ "species_10473801" ], "modifiers": [], "additional_components": [ "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "A1ZBK9", "FBgn0034446", "species_29438", "A1ZBK9", "FBgn0034446", "species_29438", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280" ] }, "reaction_10473835": { "compartment": "compartment_261122", "id": "reaction_10473835", "reactome": "R-DME-5624127", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473801" ], "products": [ "species_10473833" ], "modifiers": [], "additional_components": [ "A1ZBK9", "FBgn0034446", "species_29438", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280", "species_29438", "A1ZBK9", "FBgn0034446", "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260" ] }, "reaction_10488803": { "compartment": "compartment_984", "id": "reaction_10488803", "reactome": "R-DME-8852809", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488798" ], "products": [ "species_10488800" ], "modifiers": [ [ "species_10464252", "catalyst" ] ], "additional_components": [ "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VCM8", "FBgn0039073", "Q961J8", "FBgn0035781", "Q7JYV3", "FBgn0033774", "Q9W478", "FBgn0029804", "Q0E9F9", "FBgn0033241", "Q9W477", "FBgn0259149", "M9PEV1", "FBgn0035776", "Q9W475", "FBgn0029807", "Q9VX86", "FBgn0030815", "Q9VS80", "FBgn0035791", "Q9VS67", "FBgn0035780", "Q9VS66", "FBgn0035779", "Q9VS65", "FBgn0052379", "Q9VS64", "FBgn0035777", "Q9VRZ3", "FBgn0035718", "Q9VLZ2", "FBgn0031929", "Q9VLZ1", "FBgn0031930", "Q9VL87", "FBgn0032143", "Q9VL86", "FBgn0032144" ] }, "reaction_10455979": { "compartment": "compartment_984", "id": "reaction_10455979", "reactome": "R-DME-976801", "name": "Complement factor I complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455955", "species_10455975" ], "products": [ "species_10455977" ], "modifiers": [], "additional_components": [ "A1Z7M3", "FBgn0265011", "A8DY75", "FBgn0033362", "Q9VRS5", "FBgn0035663", "A1Z709", "FBgn0033192", "A1Z7M7", "FBgn0033365", "Q05319", "FBgn0003319", "A1Z7M5", "FBgn0033363", "B7YZU2", "FBgn0286782", "Q9VZH5", "FBgn0035501", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319" ] }, "reaction_10457578": { "compartment": "compartment_876", "id": "reaction_10457578", "reactome": "R-DME-1006143", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456081", "species_10456083" ], "products": [ "species_10456085" ], "modifiers": [], "additional_components": [ "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10467082": { "compartment": "compartment_984", "id": "reaction_10467082", "reactome": "R-DME-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10437245" ], "products": [ "species_10456099" ], "modifiers": [], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10493671": { "compartment": "compartment_876", "id": "reaction_10493671", "reactome": "R-DME-8951486", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456081", "species_10456122" ], "products": [ "species_10456124" ], "modifiers": [], "additional_components": [ "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10456231": { "compartment": "compartment_876", "id": "reaction_10456231", "reactome": "R-DME-977615", "name": "Factor I inactivates MCP/CR1-bound C4b/C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456132" ], "products": [ "species_10456228", "species_10455977", "species_10456186", "species_10456188" ], "modifiers": [ [ "species_10456132", "catalyst" ] ], "additional_components": [ "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10456134": { "compartment": "compartment_876", "id": "reaction_10456134", "reactome": "R-DME-977602", "name": "Complement factor I binds to MCP, CR1:C4b, C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456130", "species_10455977" ], "products": [ "species_10456132" ], "modifiers": [], "additional_components": [ "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10468164": { "compartment": "compartment_876", "id": "reaction_10468164", "reactome": "R-DME-3266557", "name": "Factor I cleaves iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468123" ], "products": [ "species_10468161", "species_10468149", "species_10456075" ], "modifiers": [ [ "species_10455977", "catalyst" ] ], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319" ] }, "reaction_10488811": { "compartment": "compartment_876", "id": "reaction_10488811", "reactome": "R-DME-8852874", "name": "CR2 binds C3d, C3dg, iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488807", "species_10488805" ], "products": [ "species_10488809" ], "modifiers": [], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "FBgn0001083", "Q9VYR4", "FBgn0001083", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180" ] }, "reaction_10459709": { "compartment": "compartment_12045", "id": "reaction_10459709", "reactome": "R-DME-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10459706", "catalyst" ] ], "additional_components": [ "Q960U8", "FBgn0004797", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216", "Q7K1C2", "FBgn0033215" ] }, "reaction_10479149": { "compartment": "compartment_12045", "id": "reaction_10479149", "reactome": "R-DME-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10459644": { "compartment": "compartment_12045", "id": "reaction_10459644", "reactome": "R-DME-1482654", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728" ], "products": [ "species_76116", "species_1500596" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10459642": { "compartment": "compartment_12045", "id": "reaction_10459642", "reactome": "R-DME-1482647", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_1500596" ], "products": [ "species_76116", "species_1500594" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10459672": { "compartment": "compartment_12045", "id": "reaction_10459672", "reactome": "R-DME-1482777", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500594" ], "products": [ "species_1524021", "species_1500596" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10459686": { "compartment": "compartment_12045", "id": "reaction_10459686", "reactome": "R-DME-1482811", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500596" ], "products": [ "species_1498728", "species_1524021" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10487933": { "compartment": "compartment_12045", "id": "reaction_10487933", "reactome": "R-DME-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10487930", "catalyst" ] ], "additional_components": [ "A1Z739", "FBgn0033216", "Q7JYK2", "FBgn0033214", "Q7K1C2", "FBgn0033215" ] }, "reaction_10459690": { "compartment": "compartment_70616", "id": "reaction_10459690", "reactome": "R-DME-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524083", "species_1498773" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10459677", "catalyst" ] ], "additional_components": [ "FBgn0026619" ] }, "reaction_10459683": { "compartment": "compartment_70616", "id": "reaction_10459683", "reactome": "R-DME-1482794", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524079" ], "products": [ "species_1524075", "species_1498773" ], "modifiers": [ [ "species_10459677", "catalyst" ] ], "additional_components": [ "FBgn0026619" ] }, "reaction_10459667": { "compartment": "compartment_70616", "id": "reaction_10459667", "reactome": "R-DME-1482775", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524038" ], "products": [ "species_1524072", "species_29374" ], "modifiers": [ [ "species_10459664", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10479135": { "compartment": "compartment_5460", "id": "reaction_10479135", "reactome": "R-DME-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696414", "species_113521" ], "products": [ "species_113548", "species_113532", "species_5693978" ], "modifiers": [ [ "species_10479132", "catalyst" ] ], "additional_components": [ "Q9VU95", "FBgn0036381" ] }, "reaction_10459804": { "compartment": "compartment_70101", "id": "reaction_10459804", "reactome": "R-DME-1483096", "name": "PETA is dephosphorylated to ETA by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428686" ], "products": [ "species_29372", "species_1498751" ], "modifiers": [ [ "species_10459801", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VWF3", "FBgn0031045", "Q9VWF0", "FBgn0031048" ] }, "reaction_10459850": { "compartment": "compartment_12045", "id": "reaction_10459850", "reactome": "R-DME-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428686", "species_110614" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10459847", "catalyst" ] ], "additional_components": [ "Q9VK25", "FBgn0032482" ] }, "reaction_10459861": { "compartment": "compartment_12045", "id": "reaction_10459861", "reactome": "R-DME-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10459858", "catalyst" ] ], "additional_components": [ "species_29926", "Q8SXP0", "FBgn0263593" ] }, "reaction_10459733": { "compartment": "compartment_12045", "id": "reaction_10459733", "reactome": "R-DME-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10459730", "catalyst" ] ], "additional_components": [ "species_29926", "species_266099", "Q9VIU4", "FBgn0053116", "Q8T0S3", "FBgn0031948" ] }, "reaction_10459873": { "compartment": "compartment_70101", "id": "reaction_10459873", "reactome": "R-DME-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10459870", "catalyst" ] ], "additional_components": [ "Q8IMF4", "FBgn0032955", "P54352", "FBgn0000536" ] }, "reaction_10459743": { "compartment": "compartment_12045", "id": "reaction_10459743", "reactome": "R-DME-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_426639", "species_109395" ], "modifiers": [ [ "species_10459740", "catalyst" ] ], "additional_components": [ "Q8SX37", "FBgn0030670", "species_29926", "species_266099" ] }, "reaction_10459814": { "compartment": "compartment_12045", "id": "reaction_10459814", "reactome": "R-DME-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_111294", "species_426955" ], "modifiers": [ [ "species_10459811", "catalyst" ] ], "additional_components": [ "species_29926", "P56079", "FBgn0010350" ] }, "reaction_10490382": { "compartment": "compartment_70101", "id": "reaction_10490382", "reactome": "R-DME-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10490379", "catalyst" ] ], "additional_components": [ "P43125", "FBgn0003218", "Q9VLS7", "FBgn0031990" ] }, "reaction_10459764": { "compartment": "compartment_70616", "id": "reaction_10459764", "reactome": "R-DME-1483063", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_1524064" ], "products": [ "species_1524072", "species_1524067" ], "modifiers": [ [ "species_10459585", "catalyst" ] ], "additional_components": [ "FBgn0039360" ] }, "reaction_10479092": { "compartment": "compartment_17906", "id": "reaction_10479092", "reactome": "R-DME-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696066", "species_5696069" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10479089", "catalyst" ] ], "additional_components": [ "species_5696449", "species_114519", "species_1500590", "species_417891", "Q9VL10", "FBgn0260750", "species_29926" ] }, "reaction_10459840": { "compartment": "compartment_12045", "id": "reaction_10459840", "reactome": "R-DME-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10459837", "catalyst" ] ], "additional_components": [ "FBgn0287585" ] }, "reaction_10490948": { "compartment": "compartment_12045", "id": "reaction_10490948", "reactome": "R-DME-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10490945", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36313", "CHEBI:36314", "FBgn0039681" ] }, "reaction_10459577": { "compartment": "compartment_12045", "id": "reaction_10459577", "reactome": "R-DME-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10459574", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q0KHU5", "FBgn0052699", "Q6NN55", "FBgn0033476" ] }, "reaction_10459688": { "compartment": "compartment_12045", "id": "reaction_10459688", "reactome": "R-DME-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10460328": { "compartment": "compartment_984", "id": "reaction_10460328", "reactome": "R-DME-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10460293", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9W3I8", "FBgn0030013", "Q9VYG9", "FBgn0250862", "Q7JX94", "FBgn0050503", "Q9W4I0", "FBgn0029720", "Q6XPX3", "FBgn0033170", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459591": { "compartment": "compartment_12045", "id": "reaction_10459591", "reactome": "R-DME-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10459574", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q0KHU5", "FBgn0052699", "Q6NN55", "FBgn0033476" ] }, "reaction_10460326": { "compartment": "compartment_984", "id": "reaction_10460326", "reactome": "R-DME-1602399", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10455770", "catalyst" ] ], "additional_components": [ "FBgn0036939" ] }, "reaction_10459698": { "compartment": "compartment_12045", "id": "reaction_10459698", "reactome": "R-DME-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10459613": { "compartment": "compartment_12045", "id": "reaction_10459613", "reactome": "R-DME-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10432542", "catalyst" ] ], "additional_components": [ "FBgn0052699" ] }, "reaction_10459580": { "compartment": "compartment_12045", "id": "reaction_10459580", "reactome": "R-DME-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10432542", "catalyst" ] ], "additional_components": [ "FBgn0052699" ] }, "reaction_10459658": { "compartment": "compartment_70616", "id": "reaction_10459658", "reactome": "R-DME-1482689", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524027", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10459585", "catalyst" ] ], "additional_components": [ "FBgn0039360" ] }, "reaction_10460313": { "compartment": "compartment_984", "id": "reaction_10460313", "reactome": "R-DME-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602402" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10460293", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9W3I8", "FBgn0030013", "Q9VYG9", "FBgn0250862", "Q7JX94", "FBgn0050503", "Q9W4I0", "FBgn0029720", "Q6XPX3", "FBgn0033170", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459716": { "compartment": "compartment_12045", "id": "reaction_10459716", "reactome": "R-DME-1482907", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10459588": { "compartment": "compartment_70616", "id": "reaction_10459588", "reactome": "R-DME-1482546", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524047", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10459585", "catalyst" ] ], "additional_components": [ "FBgn0039360" ] }, "reaction_10459714": { "compartment": "compartment_12045", "id": "reaction_10459714", "reactome": "R-DME-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10459604", "catalyst" ] ], "additional_components": [ "FBgn0039655" ] }, "reaction_10459599": { "compartment": "compartment_12045", "id": "reaction_10459599", "reactome": "R-DME-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10459596", "catalyst" ] ], "additional_components": [ "FBgn0031815" ] }, "reaction_10459610": { "compartment": "compartment_12045", "id": "reaction_10459610", "reactome": "R-DME-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10459596", "catalyst" ] ], "additional_components": [ "FBgn0031815" ] }, "reaction_10459700": { "compartment": "compartment_12045", "id": "reaction_10459700", "reactome": "R-DME-1482868", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10460321": { "compartment": "compartment_984", "id": "reaction_10460321", "reactome": "R-DME-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_426658" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10460316", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459646": { "compartment": "compartment_70101", "id": "reaction_10459646", "reactome": "R-DME-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10459604", "catalyst" ] ], "additional_components": [ "FBgn0039655" ] }, "reaction_10459832": { "compartment": "compartment_12045", "id": "reaction_10459832", "reactome": "R-DME-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10459827", "catalyst" ] ], "additional_components": [ "FBgn0286511" ] }, "reaction_10459607": { "compartment": "compartment_17906", "id": "reaction_10459607", "reactome": "R-DME-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500590" ], "products": [ "species_1500580", "species_1524103" ], "modifiers": [ [ "species_10459604", "catalyst" ] ], "additional_components": [ "FBgn0039655" ] }, "reaction_10481009": { "compartment": "compartment_876", "id": "reaction_10481009", "reactome": "R-DME-6792445", "name": "LIPH, I hydrolyse PA to 2-acyl LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_6792472", "species_1602366" ], "modifiers": [ [ "species_10481006", "catalyst" ] ], "additional_components": [ "Q9VU78", "FBgn0036367", "Q9VRW5", "FBgn0035697", "Q9VLU1", "FBgn0031976", "Q9VJH1", "FBgn0032612", "Q9VEY9", "FBgn0038398", "Q9VBQ2", "FBgn0039344", "Q9VB94", "FBgn0039470", "Q9VB93", "FBgn0039471", "Q9VB92", "FBgn0039472", "Q9VB91", "FBgn0039473", "Q9VB90", "FBgn0039474", "Q9VB89", "FBgn0039475", "Q9VB88", "FBgn0039476", "Q7K3Z8", "FBgn0032029", "Q4V566", "FBgn0085476", "Q0E8T1", "FBgn0250847", "P06607", "FBgn0004047", "P02844", "FBgn0005391", "P02843", "FBgn0004045", "M9NFL7", "FBgn0036977", "M9MRT1", "FBgn0032289", "A8DYT7", "FBgn0085477", "A1ZAL5", "FBgn0034166", "Q9W448", "FBgn0029831", "Q9W304", "FBgn0030162", "Q9VZN6", "FBgn0035453", "Q9VX70", "FBgn0265267", "Q9VX69", "FBgn0030828", "Q9VX01", "FBgn0030884" ] }, "reaction_10453360": { "compartment": "compartment_12045", "id": "reaction_10453360", "reactome": "R-DME-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_1500604", "species_76194" ], "modifiers": [ [ "species_10432535", "catalyst" ] ], "additional_components": [ "FBgn0031132" ] }, "reaction_10459662": { "compartment": "compartment_17906", "id": "reaction_10459662", "reactome": "R-DME-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10432552", "catalyst" ] ], "additional_components": [ "FBgn0027579" ] }, "reaction_10460330": { "compartment": "compartment_984", "id": "reaction_10460330", "reactome": "R-DME-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10460316", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10495095": { "compartment": "compartment_17906", "id": "reaction_10495095", "reactome": "R-DME-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10495077", "catalyst" ], [ "species_10495093", "catalyst" ] ], "additional_components": [ "Q9VKD7", "FBgn0261266", "Q9W3F7", "FBgn0030037" ] }, "reaction_10459655": { "compartment": "compartment_12045", "id": "reaction_10459655", "reactome": "R-DME-1482679", "name": "PA is hydrolysed to 1-acyl LPA by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10432547": { "compartment": "compartment_12045", "id": "reaction_10432547", "reactome": "R-DME-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10432544", "catalyst" ] ], "additional_components": [ "Q0KHU5", "FBgn0052699", "Q9VRC1", "FBgn0031132", "Q9VYJ4", "FBgn0030421", "Q7KTI0", "FBgn0026718", "D5AEK7", "FBgn0036623", "Q9VV49", "FBgn0036622" ] }, "reaction_10432609": { "compartment": "compartment_70101", "id": "reaction_10432609", "reactome": "R-DME-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75970", "species_73473" ], "products": [ "species_76114", "species_29360" ], "modifiers": [ [ "species_10432606", "catalyst" ] ], "additional_components": [ "P13706", "FBgn0001128", "Q9W1U3", "FBgn0034825", "Q8IN06", "FBgn0263048" ] }, "reaction_10493857": { "compartment": "compartment_984", "id": "reaction_10493857", "reactome": "R-DME-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2173763" ], "products": [ "species_8954142", "species_8952253" ], "modifiers": [ [ "species_10493854", "catalyst" ] ], "additional_components": [ "Q9I7L9", "FBgn0042175", "Q9Y168", "FBgn0051683" ] }, "reaction_10460319": { "compartment": "compartment_984", "id": "reaction_10460319", "reactome": "R-DME-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10460316", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459660": { "compartment": "compartment_12045", "id": "reaction_10459660", "reactome": "R-DME-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10459669": { "compartment": "compartment_12045", "id": "reaction_10459669", "reactome": "R-DME-1482776", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1524021", "species_1498724" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10459620": { "compartment": "compartment_12045", "id": "reaction_10459620", "reactome": "R-DME-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10459704": { "compartment": "compartment_12045", "id": "reaction_10459704", "reactome": "R-DME-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10459623": { "compartment": "compartment_12045", "id": "reaction_10459623", "reactome": "R-DME-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10479047": { "compartment": "compartment_70101", "id": "reaction_10479047", "reactome": "R-DME-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694568", "species_29356" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10479044", "catalyst" ] ], "additional_components": [ "FBgn0033226" ] }, "reaction_10459702": { "compartment": "compartment_12045", "id": "reaction_10459702", "reactome": "R-DME-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10460323": { "compartment": "compartment_984", "id": "reaction_10460323", "reactome": "R-DME-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602375", "species_109276" ], "products": [ "species_1602372", "species_1602366" ], "modifiers": [ [ "species_10460293", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9W3I8", "FBgn0030013", "Q9VYG9", "FBgn0250862", "Q7JX94", "FBgn0050503", "Q9W4I0", "FBgn0029720", "Q6XPX3", "FBgn0033170", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459648": { "compartment": "compartment_12045", "id": "reaction_10459648", "reactome": "R-DME-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10459787": { "compartment": "compartment_12045", "id": "reaction_10459787", "reactome": "R-DME-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10459784", "catalyst" ] ], "additional_components": [ "Q9W0D9", "FBgn0035231", "Q7K4C7", "FBgn0041342" ] }, "reaction_10443498": { "compartment": "compartment_70101", "id": "reaction_10443498", "reactome": "R-DME-264622", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_76183" ], "products": [ "species_264643", "species_76194" ], "modifiers": [ [ "species_10443495", "catalyst" ] ], "additional_components": [ "FBgn0000303" ] }, "reaction_10459817": { "compartment": "compartment_70101", "id": "reaction_10459817", "reactome": "R-DME-1483159", "name": "PCho is dephosphorylated to Cho by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524071" ], "products": [ "species_264618", "species_29372" ], "modifiers": [ [ "species_10459801", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VWF3", "FBgn0031045", "Q9VWF0", "FBgn0031048" ] }, "reaction_10491447": { "compartment": "compartment_12045", "id": "reaction_10491447", "reactome": "R-DME-8877153", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10491443" ], "products": [ "species_10491445" ], "modifiers": [], "additional_components": [ "FBgn0032513", "Q9VJZ2", "FBgn0032513", "species_429802" ] }, "reaction_10479012": { "compartment": "compartment_876", "id": "reaction_10479012", "reactome": "R-DME-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694502" ], "products": [ "species_5694457", "species_1861754" ], "modifiers": [ [ "species_10479009", "catalyst" ] ], "additional_components": [ "FBgn0033382" ] }, "reaction_10459761": { "compartment": "compartment_70101", "id": "reaction_10459761", "reactome": "R-DME-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10459758", "catalyst" ] ], "additional_components": [ "Q8IMF4", "FBgn0032955" ] }, "reaction_10465406": { "compartment": "compartment_161320", "id": "reaction_10465406", "reactome": "R-DME-2213240", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213221" ], "products": [ "species_2213225" ], "modifiers": [ [ "species_10465403", "catalyst" ] ], "additional_components": [ "Q9VCK1", "FBgn0039099", "Q95RA9", "FBgn0038149", "Q9VHA5", "FBgn0037721", "Q9VCK2", "FBgn0039098" ] }, "reaction_10465008": { "compartment": "compartment_161320", "id": "reaction_10465008", "reactome": "R-DME-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10465005", "catalyst" ] ], "additional_components": [ "Q9VN93", "FBgn0260462", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q7K485", "FBgn0029093" ] }, "reaction_10431263": { "compartment": "compartment_70101", "id": "reaction_10431263", "reactome": "R-DME-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111354", "species_113592", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_111369" ], "modifiers": [ [ "species_10431260", "catalyst" ] ], "additional_components": [ "FBgn0000052" ] }, "reaction_10434110": { "compartment": "compartment_70101", "id": "reaction_10434110", "reactome": "R-DME-111289", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434106" ], "products": [ "species_10431276" ], "modifiers": [ [ "species_73566", "catalyst" ] ], "additional_components": [ "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793", "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793" ] }, "reaction_10431198": { "compartment": "compartment_70101", "id": "reaction_10431198", "reactome": "R-DME-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10431195", "catalyst" ] ], "additional_components": [ "FBgn0000239" ] }, "reaction_10434142": { "compartment": "compartment_70101", "id": "reaction_10434142", "reactome": "R-DME-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10434139", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_35141", "inhibitor" ], [ "species_113578", "inhibitor" ] ], "additional_components": [ "species_29926", "Q9Y0Y2", "FBgn0027493" ] }, "reaction_10434108": { "compartment": "compartment_70101", "id": "reaction_10434108", "reactome": "R-DME-111285", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431276" ], "products": [ "species_10434106" ], "modifiers": [ [ "species_29602", "catalyst" ], [ "species_113578", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793", "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793" ] }, "reaction_10431224": { "compartment": "compartment_70101", "id": "reaction_10431224", "reactome": "R-DME-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419151", "species_111409" ], "products": [ "species_111355", "species_111427" ], "modifiers": [ [ "species_10431218", "catalyst" ] ], "additional_components": [ "Q9VC18", "FBgn0039241" ] }, "reaction_10431255": { "compartment": "compartment_70101", "id": "reaction_10431255", "reactome": "R-DME-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_29372", "species_111370", "species_29370" ], "modifiers": [ [ "species_10431252", "catalyst" ] ], "additional_components": [ "FBgn0000053" ] }, "reaction_10498472": { "compartment": "compartment_70101", "id": "reaction_10498472", "reactome": "R-DME-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10431205" ], "products": [ "species_10431208" ], "modifiers": [], "additional_components": [ "Q07152", "FBgn0003204", "Q07152", "FBgn0003204" ] }, "reaction_10431221": { "compartment": "compartment_70101", "id": "reaction_10431221", "reactome": "R-DME-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29356", "species_29602" ], "modifiers": [ [ "species_10431218", "catalyst" ] ], "additional_components": [ "Q9VC18", "FBgn0039241" ] }, "reaction_10431281": { "compartment": "compartment_70101", "id": "reaction_10431281", "reactome": "R-DME-73828", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_35141" ], "products": [ "species_29586", "species_76577" ], "modifiers": [ [ "species_10431231", "catalyst" ] ], "additional_components": [ "Q9VEP6", "FBgn0038467" ] }, "reaction_10431279": { "compartment": "compartment_70101", "id": "reaction_10431279", "reactome": "R-DME-73815", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_29356", "species_29472" ], "products": [ "species_111294", "species_111292", "species_29404" ], "modifiers": [ [ "species_10431276", "catalyst" ] ], "additional_components": [ "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793" ] }, "reaction_10431247": { "compartment": "compartment_70101", "id": "reaction_10431247", "reactome": "R-DME-73806", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111370", "species_113528" ], "products": [ "species_111395" ], "modifiers": [ [ "species_10431241", "catalyst" ] ], "additional_components": [ "Q9I7S8", "FBgn0020513" ] }, "reaction_10431244": { "compartment": "compartment_70101", "id": "reaction_10431244", "reactome": "R-DME-73805", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29448", "species_111395" ], "products": [ "species_29372", "species_29370", "species_111399" ], "modifiers": [ [ "species_10431241", "catalyst" ] ], "additional_components": [ "Q9I7S8", "FBgn0020513" ] }, "reaction_10431210": { "compartment": "compartment_70101", "id": "reaction_10431210", "reactome": "R-DME-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29602", "species_29360" ], "products": [ "species_70106", "species_111584", "species_73473" ], "modifiers": [ [ "species_10431205", "catalyst" ], [ "species_10431208", "inhibitor" ], [ "species_111584", "inhibitor" ] ], "additional_components": [ "Q07152", "FBgn0003204", "Q07152", "FBgn0003204" ] }, "reaction_10431269": { "compartment": "compartment_70101", "id": "reaction_10431269", "reactome": "R-DME-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111292", "species_113592", "species_29424" ], "products": [ "species_29372", "species_111338", "species_29370" ], "modifiers": [ [ "species_10431252", "catalyst" ] ], "additional_components": [ "FBgn0000053" ] }, "reaction_10431266": { "compartment": "compartment_70101", "id": "reaction_10431266", "reactome": "R-DME-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_111354", "species_111355" ], "modifiers": [ [ "species_10431252", "catalyst" ] ], "additional_components": [ "FBgn0000053" ] }, "reaction_10431234": { "compartment": "compartment_70101", "id": "reaction_10431234", "reactome": "R-DME-73800", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111399" ], "products": [ "species_29586", "species_111409" ], "modifiers": [ [ "species_10431231", "catalyst" ] ], "additional_components": [ "Q9VEP6", "FBgn0038467" ] }, "reaction_10498768": { "compartment": "compartment_70101", "id": "reaction_10498768", "reactome": "R-DME-9708536", "name": "HMOX1 translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497417" ], "products": [ "species_10498766" ], "modifiers": [], "additional_components": [ "FBgn0037933", "FBgn0037933" ] }, "reaction_10498774": { "compartment": "compartment_70101", "id": "reaction_10498774", "reactome": "R-DME-9708558", "name": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439555" ], "products": [ "species_10498772" ], "modifiers": [], "additional_components": [ "Q9VGJ9", "FBgn0037933", "Q9VGJ9", "FBgn0037933" ] }, "reaction_10498760": { "compartment": "compartment_12045", "id": "reaction_10498760", "reactome": "R-DME-9708457", "name": "HM13 cleaves HMOX1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439555" ], "products": [ "species_10497417" ], "modifiers": [ [ "species_10498757", "catalyst" ] ], "additional_components": [ "Q9VGJ9", "FBgn0037933", "FBgn0037933", "FBgn0031260" ] }, "reaction_10498762": { "compartment": "compartment_70101", "id": "reaction_10498762", "reactome": "R-DME-9708466", "name": "BACH1 translocates from the nucleoplasm to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498736" ], "products": [ "species_10498744" ], "modifiers": [ [ "species_3785707", "catalyst" ] ], "additional_components": [ "FBgn0030417", "FBgn0030417" ] }, "reaction_10491908": { "compartment": "compartment_70101", "id": "reaction_10491908", "reactome": "R-DME-8932327", "name": "NFE2L2 binds KEAP1:CUL3:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491902", "species_10491904" ], "products": [ "species_10491906" ], "modifiers": [], "additional_components": [ "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975" ] }, "reaction_10498789": { "compartment": "compartment_70101", "id": "reaction_10498789", "reactome": "R-DME-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9714134", "species_10491906" ], "products": [ "species_10498787" ], "modifiers": [], "additional_components": [ "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975" ] }, "reaction_10491912": { "compartment": "compartment_70101", "id": "reaction_10491912", "reactome": "R-DME-8932334", "name": "KEAP1:CUL3:RBX1:NFE2L2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491906", "species_10491904" ], "products": [ "species_10491902", "species_10491910" ], "modifiers": [], "additional_components": [ "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268" ] }, "reaction_10491900": { "compartment": "compartment_70101", "id": "reaction_10491900", "reactome": "R-DME-8932309", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491892" ], "products": [ "species_10491898" ], "modifiers": [], "additional_components": [] }, "reaction_10491917": { "compartment": "compartment_70101", "id": "reaction_10491917", "reactome": "R-DME-8932351", "name": "KEAP1 facilitates ubiquitination of NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10491906" ], "products": [ "species_10491914", "species_10491904" ], "modifiers": [ [ "species_10491906", "catalyst" ], [ "species_1250243", "inhibitor" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P20482", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975" ] }, "reaction_10491919": { "compartment": "compartment_70101", "id": "reaction_10491919", "reactome": "R-DME-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491914" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P20482", "FBgn0262975", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10439548": { "compartment": "compartment_70101", "id": "reaction_10439548", "reactome": "R-DME-189384", "name": "BLVRA:Zn2+, BLVRB reduce BV to BIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189396", "species_29364" ], "products": [ "species_189386", "species_29366" ], "modifiers": [ [ "species_10439545", "catalyst" ] ], "additional_components": [ "FBgn0037749" ] }, "reaction_10439562": { "compartment": "compartment_70101", "id": "reaction_10439562", "reactome": "R-DME-189398", "name": "HMOX1 dimer, HMOX2 cleave heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364", "species_71185" ], "products": [ "species_29356", "species_189385", "species_71067", "species_189396", "species_29366" ], "modifiers": [ [ "species_10439559", "catalyst" ] ], "additional_components": [ "Q9VGJ9", "FBgn0037933" ] }, "reaction_10436293": { "compartment": "compartment_70616", "id": "reaction_10436293", "reactome": "R-DME-163214", "name": "Electron transfer from reduced cytochrome c to molecular oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_10436148", "species_113529" ], "products": [ "species_10436150", "species_163953", "species_113521" ], "modifiers": [ [ "species_10436237", "catalyst" ], [ "species_10436243", "catalyst" ], [ "species_10436265", "catalyst" ], [ "species_10436289", "catalyst" ], [ "species_10436291", "inhibitor" ] ], "additional_components": [ "CHEBI:38573", "P84029", "FBgn0284248", "CHEBI:38574", "P84029", "FBgn0284248", "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "FBgn0260222", "Q9VF98", "FBgn0011476", "Q9VMQ6", "FBgn0051648", "Q9VST8", "FBgn0035960", "Q9VG00", "FBgn0002354", "Q9VL11", "FBgn0032205", "Q9VJ86", "FBgn0284256", "Q9U4F3", "FBgn0029117", "Q9VMX4", "FBgn0262467", "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "species_9709326" ] }, "reaction_10498783": { "compartment": "compartment_70616", "id": "reaction_10498783", "reactome": "R-DME-9709406", "name": "CO binds to Cytochrome c oxidase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9709326", "species_10436237" ], "products": [ "species_10436291" ], "modifiers": [], "additional_components": [ "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "species_9709326" ] }, "reaction_10498367": { "compartment": "compartment_70101", "id": "reaction_10498367", "reactome": "R-DME-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10443830", "catalyst" ] ], "additional_components": [ "FBgn0032456" ] }, "reaction_10445949": { "compartment": "compartment_12045", "id": "reaction_10445949", "reactome": "R-DME-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445937" ], "products": [ "species_10445939" ], "modifiers": [], "additional_components": [ "FBgn0261984", "A8JR46", "FBgn0261984" ] }, "reaction_10445947": { "compartment": "compartment_12045", "id": "reaction_10445947", "reactome": "R-DME-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445939", "species_113592" ], "products": [ "species_29370", "species_10445944" ], "modifiers": [ [ "species_10445939", "catalyst" ] ], "additional_components": [ "A8JR46", "FBgn0261984", "A8JR46", "FBgn0261984", "A8JR46", "FBgn0261984" ] }, "reaction_10498384": { "compartment": "compartment_70101", "id": "reaction_10498384", "reactome": "R-DME-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498382" ], "products": [ "species_189386", "species_10471582" ], "modifiers": [], "additional_components": [ "Q8INK3", "FBgn0037913", "species_9661418", "FBgn0037913" ] }, "reaction_10498386": { "compartment": "compartment_70101", "id": "reaction_10498386", "reactome": "R-DME-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10471582" ], "products": [ "species_10498382" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_9661418" ] }, "reaction_10498370": { "compartment": "compartment_70101", "id": "reaction_10498370", "reactome": "R-DME-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10455124", "catalyst" ] ], "additional_components": [ "CHEBI:18392", "CHEBI:16427", "CHEBI:16427", "CHEBI:18392", "P45843", "FBgn0003515", "P12428", "FBgn0000241", "Q0KI14", "FBgn0051121" ] }, "reaction_10498375": { "compartment": "compartment_876", "id": "reaction_10498375", "reactome": "R-DME-9661723", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10498372", "catalyst" ] ], "additional_components": [ "FBgn0032123" ] }, "reaction_10498380": { "compartment": "compartment_70101", "id": "reaction_10498380", "reactome": "R-DME-9661799", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10498377", "catalyst" ] ], "additional_components": [ "FBgn0032123" ] }, "reaction_10498365": { "compartment": "compartment_70101", "id": "reaction_10498365", "reactome": "R-DME-9661397", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10454191", "catalyst" ] ], "additional_components": [ "FBgn0032123" ] }, "reaction_10486017": { "compartment": "compartment_7660", "id": "reaction_10486017", "reactome": "R-DME-6804441", "name": "RNF34 or RFFL ubiquitinates phosphorylated TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10427430" ], "products": [ "species_10486010" ], "modifiers": [ [ "species_10486012", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8IMZ4", "FBgn0039044", "FBgn0033783" ] }, "reaction_10481097": { "compartment": "compartment_70101", "id": "reaction_10481097", "reactome": "R-DME-6793685", "name": "Ubiquitinated TP53 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467609" ], "products": [ "species_10481095" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10467619": { "compartment": "compartment_7660", "id": "reaction_10467619", "reactome": "R-DME-3215310", "name": "USP7 deubiquitinates TP53 and counteracts MDM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10467609" ], "products": [ "species_10427430", "species_10467611" ], "modifiers": [ [ "species_10467616", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8IMZ4", "FBgn0039044", "FBgn0030366" ] }, "reaction_10495584": { "compartment": "compartment_70101", "id": "reaction_10495584", "reactome": "R-DME-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495580" ], "products": [ "species_10495578", "species_29368" ], "modifiers": [], "additional_components": [ "species_113535", "species_71185", "Q9VF15", "FBgn0027657", "species_71185", "Q9VF15", "FBgn0027657" ] }, "reaction_10495582": { "compartment": "compartment_70101", "id": "reaction_10495582", "reactome": "R-DME-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495578", "species_29368" ], "products": [ "species_10495580" ], "modifiers": [], "additional_components": [ "species_71185", "Q9VF15", "FBgn0027657", "species_113535", "species_71185", "Q9VF15", "FBgn0027657" ] }, "reaction_10471496": { "compartment": "compartment_70101", "id": "reaction_10471496", "reactome": "R-DME-5263616", "name": "MeSeO2H is reduced to MeSeOH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357694", "species_70106", "species_29364" ], "products": [ "species_5357663", "species_29356", "species_29366" ], "modifiers": [ [ "species_10431010", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VNT5", "FBgn0037170", "P91938", "FBgn0020653" ] }, "reaction_10471493": { "compartment": "compartment_70101", "id": "reaction_10471493", "reactome": "R-DME-5263614", "name": "MeSeOH is reduced to MeSeH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357663", "species_70106", "species_29364" ], "products": [ "species_29356", "species_29366", "species_5357669" ], "modifiers": [ [ "species_10431010", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VNT5", "FBgn0037170", "P91938", "FBgn0020653" ] }, "reaction_10464075": { "compartment": "compartment_70101", "id": "reaction_10464075", "reactome": "R-DME-2025890", "name": "Calcineurin binds NFATC1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10464021", "species_10464038", "species_74016" ], "products": [ "species_10464073" ], "modifiers": [], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505" ] }, "reaction_10498551": { "compartment": "compartment_70101", "id": "reaction_10498551", "reactome": "R-DME-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678991", "species_10437068" ], "products": [ "species_10498549" ], "modifiers": [], "additional_components": [ "FBgn0013954", "P48375", "FBgn0013954" ] }, "reaction_10495732": { "compartment": "compartment_70101", "id": "reaction_10495732", "reactome": "R-DME-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495726", "species_10495728" ], "products": [ "species_10495730" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10495748": { "compartment": "compartment_70101", "id": "reaction_10495748", "reactome": "R-DME-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495730" ], "products": [ "species_10495746" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495777": { "compartment": "compartment_70101", "id": "reaction_10495777", "reactome": "R-DME-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495769" ], "products": [ "species_10495775" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495763": { "compartment": "compartment_70101", "id": "reaction_10495763", "reactome": "R-DME-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495759" ], "products": [ "species_10495761" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10495767": { "compartment": "compartment_70101", "id": "reaction_10495767", "reactome": "R-DME-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495726" ], "products": [ "species_10495765" ], "modifiers": [], "additional_components": [] }, "reaction_10495771": { "compartment": "compartment_70101", "id": "reaction_10495771", "reactome": "R-DME-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495759", "species_10495728" ], "products": [ "species_10495769" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10458684": { "compartment": "compartment_876", "id": "reaction_10458684", "reactome": "R-DME-1296043", "name": "Activation of HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458681", "catalyst" ] ], "additional_components": [ "species_30389", "A1Z9N7", "FBgn0263397" ] }, "reaction_10458851": { "compartment": "compartment_876", "id": "reaction_10458851", "reactome": "R-DME-1297444", "name": "Binding of cAMP to HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458679", "species_30389" ], "products": [ "species_10458681" ], "modifiers": [], "additional_components": [ "A1Z9N7", "FBgn0263397", "species_30389", "A1Z9N7", "FBgn0263397" ] }, "reaction_10476866": { "compartment": "compartment_70101", "id": "reaction_10476866", "reactome": "R-DME-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10437507" ], "products": [ "species_10437505", "species_10437507" ], "modifiers": [ [ "species_10476863", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W422", "FBgn0029853" ] }, "reaction_10477104": { "compartment": "compartment_70101", "id": "reaction_10477104", "reactome": "R-DME-5689111", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456711", "species_10477101" ], "products": [ "species_10476869" ], "modifiers": [ [ "species_10456711", "catalyst" ] ], "additional_components": [ "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0041100", "FBgn0041100" ] }, "reaction_10459500": { "compartment": "compartment_70101", "id": "reaction_10459500", "reactome": "R-DME-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10459493", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10459498": { "compartment": "compartment_876", "id": "reaction_10459498", "reactome": "R-DME-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10459454", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9V9Y6", "FBgn0040629", "Q8IMV4", "FBgn0039235", "Q4V4S9", "FBgn0038956", "Q9VTU8", "FBgn0027843", "Q9VH26", "FBgn0037788", "Q9VB76", "FBgn0039486", "Q9V9Y8", "FBgn0039838" ] }, "reaction_10459496": { "compartment": "compartment_70101", "id": "reaction_10459496", "reactome": "R-DME-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10459493", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10459523": { "compartment": "compartment_5460", "id": "reaction_10459523", "reactome": "R-DME-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_29376" ], "products": [ "species_29896", "species_113529" ], "modifiers": [ [ "species_10459518", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10458226": { "compartment": "compartment_984", "id": "reaction_10458226", "reactome": "R-DME-1237045", "name": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10458223", "catalyst" ] ], "additional_components": [ "Q4V4S9", "FBgn0038956", "Q9V9Y8", "FBgn0039838", "Q9VTU8", "FBgn0027843", "Q9V9Y6", "FBgn0040629", "Q9VH26", "FBgn0037788", "Q8IMV4", "FBgn0039235", "Q9VB76", "FBgn0039486", "species_1562550" ] }, "reaction_10459457": { "compartment": "compartment_876", "id": "reaction_10459457", "reactome": "R-DME-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10459454", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9V9Y6", "FBgn0040629", "Q8IMV4", "FBgn0039235", "Q4V4S9", "FBgn0038956", "Q9VTU8", "FBgn0027843", "Q9VH26", "FBgn0037788", "Q9VB76", "FBgn0039486", "Q9V9Y8", "FBgn0039838" ] }, "reaction_10459521": { "compartment": "compartment_5460", "id": "reaction_10459521", "reactome": "R-DME-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29896", "species_113529" ], "products": [ "species_113521", "species_29376" ], "modifiers": [ [ "species_10459518", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10458241": { "compartment": "compartment_984", "id": "reaction_10458241", "reactome": "R-DME-1237081", "name": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10458223", "catalyst" ] ], "additional_components": [ "Q4V4S9", "FBgn0038956", "Q9V9Y8", "FBgn0039838", "Q9VTU8", "FBgn0027843", "Q9V9Y6", "FBgn0040629", "Q9VH26", "FBgn0037788", "Q8IMV4", "FBgn0039235", "Q9VB76", "FBgn0039486", "species_1562550" ] }, "reaction_10444363": { "compartment": "compartment_876", "id": "reaction_10444363", "reactome": "R-DME-372529", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444322" ], "products": [ "species_10443025", "species_10442919", "species_10444360", "species_10443003", "species_10443019", "species_10442973", "species_10443023", "species_372533" ], "modifiers": [ [ "species_10444322", "catalyst" ] ], "additional_components": [ "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0004574", "FBgn0270928", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343" ] }, "reaction_10444325": { "compartment": "compartment_70101", "id": "reaction_10444325", "reactome": "R-DME-372505", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10442919", "species_10442968", "species_10443003", "species_10442973", "species_10443487" ], "products": [ "species_10444322" ], "modifiers": [ [ "species_10443487", "catalyst" ] ], "additional_components": [ "FBgn0013343", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660" ] }, "reaction_10443490": { "compartment": "compartment_70101", "id": "reaction_10443490", "reactome": "R-DME-264615", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372511", "species_264643", "species_10443485" ], "products": [ "species_70106", "species_10443487" ], "modifiers": [ [ "species_10443479", "catalyst" ] ], "additional_components": [ "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "FBgn0270928" ] }, "reaction_10427772": { "compartment": "compartment_70101", "id": "reaction_10427772", "reactome": "R-DME-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427770" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10427800": { "compartment": "compartment_7660", "id": "reaction_10427800", "reactome": "R-DME-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427741" ], "products": [ "species_113582", "species_10427778" ], "modifiers": [ [ "species_10427797", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "FBgn0019686" ] }, "reaction_10498677": { "compartment": "compartment_70101", "id": "reaction_10498677", "reactome": "R-DME-9698844", "name": "MLKL binds HSP90:CDC37", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471010", "species_10462118", "species_10462120" ], "products": [ "species_10498675" ], "modifiers": [], "additional_components": [ "Q24276", "FBgn0011573", "P02828", "FBgn0001233", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P11346", "Raf" ] }, "reaction_10476089": { "compartment": "compartment_70101", "id": "reaction_10476089", "reactome": "R-DME-5675470", "name": "BIRC2/3 (cIAP1/2) is autoubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454480", "species_10471711" ], "products": [ "species_10476086" ], "modifiers": [ [ "species_10471711", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10440446": { "compartment": "compartment_876", "id": "reaction_10440446", "reactome": "R-DME-194187", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440408", "species_192483", "species_74113" ], "products": [ "species_83910", "species_10440410" ], "modifiers": [ [ "species_10440422", "catalyst" ], [ "species_10440444", "catalyst" ] ], "additional_components": [ "FBgn0037913", "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q8INK3", "FBgn0037913", "species_193473", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:16755", "CHEBI:28865", "Q9VXF5", "FBgn0030756", "Q9VXV4", "FBgn0030638", "P20153", "FBgn0003964", "M9ND53", "FBgn0041092", "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546" ] }, "reaction_10471675": { "compartment": "compartment_7660", "id": "reaction_10471675", "reactome": "R-DME-5340251", "name": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440435", "species_10440440", "species_10440442", "species_10440428" ], "products": [ "species_10440444" ], "modifiers": [], "additional_components": [ "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546", "FBgn0041092", "FBgn0041092", "FBgn0003964", "P20153", "FBgn0003964", "M9ND53", "FBgn0041092", "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546" ] }, "reaction_10471673": { "compartment": "compartment_7660", "id": "reaction_10471673", "reactome": "R-DME-5340195", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440433", "species_5340249" ], "products": [ "species_10440435" ], "modifiers": [], "additional_components": [ "FBgn0000546", "species_176655", "CHEBI:16755", "CHEBI:28834", "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546" ] }, "reaction_10435765": { "compartment": "compartment_70101", "id": "reaction_10435765", "reactome": "R-DME-159425", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_194096" ], "products": [ "species_111294", "species_29356", "species_194073", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "species_193473", "CHEBI:16755", "CHEBI:15519", "CHEBI:28701", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10458872": { "compartment": "compartment_876", "id": "reaction_10458872", "reactome": "R-DME-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458869", "catalyst" ] ], "additional_components": [ "Q9VHE0", "FBgn0037690", "Q9VFS9", "FBgn0038165" ] }, "reaction_10491685": { "compartment": "compartment_12045", "id": "reaction_10491685", "reactome": "R-DME-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491672" ], "products": [ "species_29420", "species_10491676", "species_10491105" ], "modifiers": [ [ "species_10491682", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9W4A0", "FBgn0015794", "species_29420", "Q9W4A0", "FBgn0015794", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935" ] }, "reaction_10491494": { "compartment": "compartment_17938", "id": "reaction_10491494", "reactome": "R-DME-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491471", "species_29438" ], "products": [ "species_29420", "species_10491477", "species_10491105" ], "modifiers": [ [ "species_10491491", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "O76742", "FBgn0015795", "species_29420", "O76742", "FBgn0015795", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VZL5", "FBgn0035470", "Q9VR38", "FBgn0031640" ] }, "reaction_10491114": { "compartment": "compartment_216813", "id": "reaction_10491114", "reactome": "R-DME-8875318", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491107" ], "products": [ "species_29420", "species_10491111", "species_10491105" ], "modifiers": [ [ "species_10474299", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29420", "P25228", "FBgn0005586", "P25228", "FBgn0005586", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0030613" ] }, "reaction_10491402": { "compartment": "compartment_70101", "id": "reaction_10491402", "reactome": "R-DME-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491388" ], "products": [ "species_29420", "species_10491105", "species_10491392" ], "modifiers": [ [ "species_10491397", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q86BK8", "FBgn0015791", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29438", "Q86BK8", "FBgn0015791", "FBgn0029756" ] }, "reaction_10491435": { "compartment": "compartment_171062", "id": "reaction_10491435", "reactome": "R-DME-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491424" ], "products": [ "species_29420", "species_10491428", "species_10491105" ], "modifiers": [ [ "species_10491430", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q7PLE9", "FBgn0039966", "species_29420", "Q7PLE9", "FBgn0039966", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0025802" ] }, "reaction_10491467": { "compartment": "compartment_5668575", "id": "reaction_10491467", "reactome": "R-DME-8877308", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491455", "species_29438" ], "products": [ "species_29420", "species_10491465", "species_10491105" ], "modifiers": [ [ "species_10474299", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "O76901", "FBgn0025382", "species_29420", "O76901", "FBgn0025382", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0030613" ] }, "reaction_10491217": { "compartment": "compartment_437051", "id": "reaction_10491217", "reactome": "R-DME-8876188", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491201" ], "products": [ "species_29420", "species_10491205", "species_10491105" ], "modifiers": [ [ "species_10491210", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "O15971", "FBgn0015789", "species_29420", "O15971", "FBgn0015789", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0025864" ] }, "reaction_10491569": { "compartment": "compartment_262783", "id": "reaction_10491569", "reactome": "R-DME-8877612", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491547" ], "products": [ "species_10491551", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491566", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9W5X0", "FBgn0031090", "species_29420", "Q9W5X0", "FBgn0031090", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "A1Z7Q5", "FBgn0027561", "P92177", "14-3-3epsilon" ] }, "reaction_10491634": { "compartment": "compartment_20699", "id": "reaction_10491634", "reactome": "R-DME-8877813", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491618" ], "products": [ "species_29420", "species_10491624", "species_10491105" ], "modifiers": [ [ "species_10491629", "catalyst" ] ], "additional_components": [ "Q9W3Q0", "FBgn0029959", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9W3Q0", "FBgn0029959", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0035229" ] }, "reaction_10491155": { "compartment": "compartment_171062", "id": "reaction_10491155", "reactome": "R-DME-8875320", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491118", "species_29438" ], "products": [ "species_29420", "species_10491126", "species_10491105" ], "modifiers": [ [ "species_10491152", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9V3I2", "FBgn0014010", "species_29420", "Q9V3I2", "FBgn0014010", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VNZ8", "FBgn0037116", "Q8MQW8", "FBgn0085443", "Q9W0H9", "FBgn0262937", "Q9VZ08", "FBgn0030286" ] }, "reaction_10491318": { "compartment": "compartment_262783", "id": "reaction_10491318", "reactome": "R-DME-8876454", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491291" ], "products": [ "species_29420", "species_10491105", "species_10491313" ], "modifiers": [ [ "species_10491315", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q8IRK9", "FBgn0067052", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q9VC31", "FBgn0051118", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "Q9VQG6", "FBgn0031460", "Q8IRK8", "FBgn0052673", "Q9VZ47", "FBgn0052671", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29438", "Q8IRK8", "FBgn0052673", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "Q9VQG6", "FBgn0031460", "Q9VZ47", "FBgn0052671", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "Q9W3D3", "FBgn0025864" ] }, "reaction_10491543": { "compartment": "compartment_13946", "id": "reaction_10491543", "reactome": "R-DME-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491502", "species_29438" ], "products": [ "species_10491516", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491540", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29420", "O18332", "FBgn0285937", "O18332", "FBgn0285937", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VLI9", "FBgn0260861", "Q8IRE3", "FBgn0286567", "Q9VSY8", "FBgn0260859", "Q9VPB6", "FBgn0037022", "A1Z8I0", "FBgn0033605", "Q95TN1", "FBgn0032204", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VW22", "FBgn0260655", "Q9VFB7", "FBgn0038303", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "Q7K2Q8", "FBgn0266723" ] }, "reaction_10491287": { "compartment": "compartment_70101", "id": "reaction_10491287", "reactome": "R-DME-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10491280" ], "products": [ "species_29370", "species_10491284" ], "modifiers": [ [ "species_10475687", "catalyst" ] ], "additional_components": [ "FBgn0025864", "FBgn0025864", "FBgn0260945" ] }, "reaction_10491384": { "compartment": "compartment_204883", "id": "reaction_10491384", "reactome": "R-DME-8876615", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491352" ], "products": [ "species_10491374", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491381", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29420", "Q9VQG6", "FBgn0031460", "O18338", "FBgn0262518", "Q9VZ47", "FBgn0052671", "Q8IR98", "FBgn0052670", "Q9W2S9", "FBgn0030221", "Q8IRK8", "FBgn0052673", "Q9W2V3", "FBgn0030200", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "Q9VQG6", "FBgn0031460", "Q9VZ47", "FBgn0052671", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "Q8IRK8", "FBgn0052673", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868" ] }, "reaction_10491960": { "compartment": "compartment_70101", "id": "reaction_10491960", "reactome": "R-DME-8933446", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10491553" ], "products": [ "species_29370", "species_10491559" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0027561", "FBgn0027561" ] }, "reaction_10491962": { "compartment": "compartment_70101", "id": "reaction_10491962", "reactome": "R-DME-8933452", "name": "YWHAE dimer binds phosphorylated DENND1 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432016", "species_10491559" ], "products": [ "species_10491564" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "FBgn0027561", "A1Z7Q5", "FBgn0027561", "P92177", "14-3-3epsilon" ] }, "reaction_10491614": { "compartment": "compartment_5668575", "id": "reaction_10491614", "reactome": "R-DME-8877760", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491593" ], "products": [ "species_10491599", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491611", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "A1Z7S3", "FBgn0002567", "species_29420", "A1Z7S3", "FBgn0002567", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q7K3N1", "FBgn0033973", "A1ZAX8", "FBgn0034261" ] }, "reaction_10490413": { "compartment": "compartment_7660", "id": "reaction_10490413", "reactome": "R-DME-8869568", "name": "NPM1 binds TFAP2A homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489710", "species_10469613" ], "products": [ "species_10490411" ], "modifiers": [ [ "species_5334804", "catalyst" ] ], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0016685", "Q27415", "FBgn0016685", "M9PIH9", "FBgn0261953" ] }, "reaction_10428447": { "compartment": "compartment_5460", "id": "reaction_10428447", "reactome": "R-DME-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70858", "species_113521" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10428381": { "compartment": "compartment_5460", "id": "reaction_10428381", "reactome": "R-DME-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10428378", "catalyst" ] ], "additional_components": [ "Q9VSL9", "FBgn0035911", "species_113596" ] }, "reaction_10453146": { "compartment": "compartment_5460", "id": "reaction_10453146", "reactome": "R-DME-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_30004", "species_29362" ], "products": [ "species_113526", "species_573404" ], "modifiers": [ [ "species_10428462", "catalyst" ] ], "additional_components": [ "Q9V8M5", "FBgn0034390" ] }, "reaction_10428473": { "compartment": "compartment_5460", "id": "reaction_10428473", "reactome": "R-DME-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428470", "catalyst" ] ], "additional_components": [ "FBgn0023537" ] }, "reaction_10453144": { "compartment": "compartment_5460", "id": "reaction_10453144", "reactome": "R-DME-508369", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_70836", "species_29362" ], "products": [ "species_70829", "species_113526" ], "modifiers": [ [ "species_10428424", "catalyst" ] ], "additional_components": [ "O18404", "FBgn0021765" ] }, "reaction_10428407": { "compartment": "compartment_5460", "id": "reaction_10428407", "reactome": "R-DME-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10428404", "catalyst" ] ], "additional_components": [ "A1Z934", "FBgn0033761" ] }, "reaction_10453142": { "compartment": "compartment_5460", "id": "reaction_10453142", "reactome": "R-DME-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70772", "species_113521" ], "products": [ "species_70744", "species_29896", "species_113593" ], "modifiers": [ [ "species_10428394", "catalyst" ] ], "additional_components": [ "Q9V9T5", "FBgn0039877", "Q9V9A7", "FBgn0042083" ] }, "reaction_10428437": { "compartment": "compartment_5460", "id": "reaction_10428437", "reactome": "R-DME-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10428434", "catalyst" ] ], "additional_components": [ "Q9W3N9", "FBgn0029969" ] }, "reaction_10428371": { "compartment": "compartment_5460", "id": "reaction_10428371", "reactome": "R-DME-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_508181", "species_113552" ], "modifiers": [ [ "species_10428368", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29702", "species_351964", "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "Q9VYD5", "FBgn0030482" ] }, "reaction_10453134": { "compartment": "compartment_70101", "id": "reaction_10453134", "reactome": "R-DME-508189", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_508187" ], "products": [ "species_29406", "species_508182" ], "modifiers": [ [ "species_10428360", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:17865", "CHEBI:16530", "species_351964", "CHEBI:58045", "species_29702", "Q9VYD5", "FBgn0030482" ] }, "reaction_10428455": { "compartment": "compartment_5460", "id": "reaction_10428455", "reactome": "R-DME-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10428452", "catalyst" ] ], "additional_components": [ "FBgn0038326" ] }, "reaction_10428417": { "compartment": "compartment_5460", "id": "reaction_10428417", "reactome": "R-DME-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10428414", "catalyst" ] ], "additional_components": [ "Q9VVU1", "FBgn0036824", "species_113596" ] }, "reaction_10428352": { "compartment": "compartment_5460", "id": "reaction_10428352", "reactome": "R-DME-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_508181" ], "products": [ "species_29362", "species_508261", "species_29376" ], "modifiers": [ [ "species_10428349", "catalyst" ] ], "additional_components": [ "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "CHEBI:15479", "species_70715", "species_70718", "Q7PLE6", "FBgn0039993", "Q9VHB8", "FBgn0037709", "species_8878387", "Q9VXY3", "FBgn0030612", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10430201": { "compartment": "compartment_7660", "id": "reaction_10430201", "reactome": "R-DME-72180", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430194" ], "products": [ "species_10430001", "species_10430036", "species_10430196", "species_10430024" ], "modifiers": [ [ "species_10430198", "catalyst" ] ], "additional_components": [ "Q02427", "FBgn0260944", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7KNF2", "FBgn0005648", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q02427", "FBgn0260944", "Q7KNF2", "FBgn0005648", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962" ] }, "reaction_10434116": { "compartment": "compartment_7660", "id": "reaction_10434116", "reactome": "R-DME-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434112" ], "products": [ "species_10434114", "species_10433259" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554" ] }, "reaction_10460039": { "compartment": "compartment_7660", "id": "reaction_10460039", "reactome": "R-DME-1592240", "name": "Formation of NRF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460033", "species_10460035", "species_10460024", "species_10460029", "species_10460031" ], "products": [ "species_10460037" ], "modifiers": [], "additional_components": [ "FBgn0052343", "FBgn0052343", "FBgn0004510", "FBgn0052343", "FBgn0052343", "M9NFF9", "FBgn0052343", "Q04688", "FBgn0004510" ] }, "reaction_10476803": { "compartment": "compartment_5460", "id": "reaction_10476803", "reactome": "R-DME-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428209", "species_113526" ], "products": [ "species_10476793", "species_5688274" ], "modifiers": [ [ "species_10476800", "catalyst" ] ], "additional_components": [ "P54385", "FBgn0001098", "P54385", "FBgn0001098", "Q8IRR5", "FBgn0029783", "species_1562550" ] }, "reaction_10476835": { "compartment": "compartment_5460", "id": "reaction_10476835", "reactome": "R-DME-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476821", "species_113526" ], "products": [ "species_5688337", "species_10476825", "species_5688274" ], "modifiers": [ [ "species_10476832", "catalyst" ] ], "additional_components": [ "Q9VP61", "FBgn0012034", "Q00637", "FBgn0010213", "P54385", "FBgn0001098", "Q00637", "FBgn0010213", "Q9VP61", "FBgn0012034", "P54385", "FBgn0001098", "Q9I7I7", "FBgn0038788", "species_1562550" ] }, "reaction_10493564": { "compartment": "compartment_70616", "id": "reaction_10493564", "reactome": "R-DME-8949580", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436868" ], "products": [ "species_10493562" ], "modifiers": [], "additional_components": [ "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081" ] }, "reaction_10458847": { "compartment": "compartment_876", "id": "reaction_10458847", "reactome": "R-DME-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458844", "catalyst" ] ], "additional_components": [ "Q9VHE0", "FBgn0037690", "Q9VFS9", "FBgn0038165" ] }, "reaction_390116": { "compartment": "compartment_70101", "id": "reaction_390116", "reactome": "R-DME-390116", "name": "Phospho FT reduces D accumulation at the plasma membrane", "reversible": "false", "notes": "There are observations that Fat (FT), Dachsous (DS), and Four-jointed (FJ) modulate the subcellular localisation of Dachs (D). In the absence of FT, D accumulates at the plasma membrane. These suggest a simple model whereby signalling through FT regulates the stability of the serine/threonine kinase, Warts (WTS), by reducing protein levels of D at the plasma membrane so it fails to interact with WTS.", "reactants": [ "species_451851", "species_451889" ], "products": [ "species_390026", "species_451851" ], "modifiers": [], "additional_components": [ "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "FBgn0000411", "FBgn0000411", "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO" ] }, "reaction_451856": { "compartment": "compartment_70101", "id": "reaction_451856", "reactome": "R-DME-451856", "name": "FT is phosphorylated by DCO", "reversible": "false", "notes": "The casein kinase 1 epsilon orthologue, Discs overgrown (DCO) phosphorylates the cytoplasmic part of FT at unknown residues.", "reactants": [ "species_113592", "species_451827" ], "products": [ "species_451851", "species_29370" ], "modifiers": [ [ "species_451827", "catalyst" ] ], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS", "O76324", "DCO", "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "P33450", "Phospho FT", "Q24292", "DS", "O76324", "DCO" ] }, "reaction_451839": { "compartment": "compartment_70101", "id": "reaction_451839", "reactome": "R-DME-451839", "name": "DCO binds to FT", "reversible": "false", "notes": "Fat (FT) is cleaved in its extracellular domain at an unknown site with the two fragments produced remaining stably associated after processing. The casein kinase 1 epsilon orthologue, Discs overgrown (DCO) binds to the cytoplasmic part of FT.", "reactants": [ "species_350966", "species_205729" ], "products": [ "species_451827" ], "modifiers": [], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS", "P33450", "Phospho FT", "Q24292", "DS", "O76324", "DCO" ] }, "reaction_350440": { "compartment": "compartment_876", "id": "reaction_350440", "reactome": "R-DME-350440", "name": "FT binds to DS in an adjacent cell", "reversible": "false", "notes": "The transmembrane non-classical cadherin Fat (FT) binds extracellularly to the transmembrane non-classical cadherin Dachsous (DS) in adjacent cells.", "reactants": [ "species_351124", "species_351109" ], "products": [ "species_350966" ], "modifiers": [], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS" ] }, "reaction_10431303": { "compartment": "compartment_5460", "id": "reaction_10431303", "reactome": "R-DME-73920", "name": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_73911" ], "products": [ "species_113529", "species_73909", "species_29362" ], "modifiers": [ [ "species_10431288", "catalyst" ] ], "additional_components": [ "Q7K3N4", "FBgn0033679" ] }, "reaction_10431475": { "compartment": "compartment_5460", "id": "reaction_10431475", "reactome": "R-DME-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_73909" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10431472", "catalyst" ] ], "additional_components": [ "Q9W058", "FBgn0035298" ] }, "reaction_10449897": { "compartment": "compartment_70101", "id": "reaction_10449897", "reactome": "R-DME-443439", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446844", "species_10447582" ], "products": [ "species_10449895" ], "modifiers": [], "additional_components": [ "FBgn0262733", "P00528", "FBgn0262733", "P11346", "Raf" ] }, "reaction_10449912": { "compartment": "compartment_70101", "id": "reaction_10449912", "reactome": "R-DME-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432006", "species_10446844" ], "products": [ "species_10449910" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P11346", "Raf", "P29310", "14-3-3zeta" ] }, "reaction_10433182": { "compartment": "compartment_5460", "id": "reaction_10433182", "reactome": "R-DME-77299", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77281" ], "products": [ "species_77284", "species_31649" ], "modifiers": [ [ "species_10433179", "catalyst" ] ], "additional_components": [ "A1ZBJ2", "FBgn0034432" ] }, "reaction_10433188": { "compartment": "compartment_5460", "id": "reaction_10433188", "reactome": "R-DME-77304", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77302" ], "products": [ "species_77272", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433186": { "compartment": "compartment_5460", "id": "reaction_10433186", "reactome": "R-DME-77303", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77300" ], "products": [ "species_113529", "species_77302", "species_29362" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433184": { "compartment": "compartment_5460", "id": "reaction_10433184", "reactome": "R-DME-77301", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77284", "species_113521" ], "products": [ "species_77300" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10427815": { "compartment": "compartment_7660", "id": "reaction_10427815", "reactome": "R-DME-69685", "name": "CHEK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427808", "species_29358" ], "products": [ "species_113582", "species_10427813" ], "modifiers": [ [ "species_10427797", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0019686" ] }, "reaction_10474328": { "compartment": "compartment_7660", "id": "reaction_10474328", "reactome": "R-DME-5628871", "name": "BRD7 promotes EP300-mediated acetylation of TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467732", "species_113560" ], "products": [ "species_2485002", "species_10474325" ], "modifiers": [ [ "species_10467732", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947", "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947", "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947" ] }, "reaction_10467734": { "compartment": "compartment_7660", "id": "reaction_10467734", "reactome": "R-DME-3222093", "name": "BRD7 binds TP53 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467730", "species_10427813", "species_10458126" ], "products": [ "species_10467732" ], "modifiers": [], "additional_components": [ "FBgn0031947", "Q8IMZ4", "FBgn0039044", "FBgn0261617", "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947" ] }, "reaction_10486189": { "compartment": "compartment_7660", "id": "reaction_10486189", "reactome": "R-DME-6805650", "name": "MTA2-NuRD complex deacetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10486149" ], "products": [ "species_10486151", "species_5566518" ], "modifiers": [ [ "species_10486186", "catalyst" ] ], "additional_components": [ "Q94517", "HDAC1", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q24572", "FBgn0263979" ] }, "reaction_10491585": { "compartment": "compartment_7660", "id": "reaction_10491585", "reactome": "R-DME-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491571" ], "products": [ "species_113582", "species_10491582" ], "modifiers": [ [ "species_10450891", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924", "Q8SXX1", "FBgn0039924", "FBgn0261524" ] }, "reaction_10487140": { "compartment": "compartment_7660", "id": "reaction_10487140", "reactome": "R-DME-6811508", "name": "ING2-bound EP300 acetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487130", "species_113560" ], "products": [ "species_2485002", "species_10487137" ], "modifiers": [ [ "species_10487130", "catalyst" ], [ "species_6810408", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044", "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044", "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10491589": { "compartment": "compartment_7660", "id": "reaction_10491589", "reactome": "R-DME-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491582", "species_10455258" ], "products": [ "species_10491587" ], "modifiers": [], "additional_components": [ "Q8SXX1", "FBgn0039924", "FBgn0015379", "P54353", "FBgn0015379", "Q8SXX1", "FBgn0039924" ] }, "reaction_10486887": { "compartment": "compartment_7660", "id": "reaction_10486887", "reactome": "R-DME-6810376", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_10469624" ], "products": [ "species_10486885" ], "modifiers": [], "additional_components": [ "FBgn0038546", "Q9VEF5", "FBgn0038546", "species_1806212" ] }, "reaction_10487132": { "compartment": "compartment_7660", "id": "reaction_10487132", "reactome": "R-DME-6811479", "name": "ING2 recruits EP300 to TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10469624", "species_10458126" ], "products": [ "species_10487130" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0038546", "FBgn0261617", "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10454653": { "compartment": "compartment_70101", "id": "reaction_10454653", "reactome": "R-DME-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446818", "species_113592" ], "products": [ "species_10454640", "species_29370" ], "modifiers": [ [ "species_10454650", "catalyst" ] ], "additional_components": [ "FBgn0264895", "FBgn0264895", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "Q03042", "FBgn0000442" ] }, "reaction_10446840": { "compartment": "compartment_70101", "id": "reaction_10446840", "reactome": "R-DME-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10446030" ], "products": [ "species_10446032" ], "modifiers": [], "additional_components": [ "FBgn0085421", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10446823": { "compartment": "compartment_70101", "id": "reaction_10446823", "reactome": "R-DME-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444262" ], "products": [ "species_111294", "species_10444300" ], "modifiers": [ [ "species_10446816", "catalyst" ], [ "species_10446821", "inhibitor" ] ], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "P08645", "FBgn0004636", "species_29420", "FBgn0264895", "P29310", "14-3-3zeta", "A8DYW8", "FBgn0264895" ] }, "reaction_10454642": { "compartment": "compartment_70101", "id": "reaction_10454642", "reactome": "R-DME-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446818", "species_10432008" ], "products": [ "species_10446821" ], "modifiers": [ [ "species_10454640", "inhibitor" ] ], "additional_components": [ "FBgn0264895", "P29310", "14-3-3zeta", "A8DYW8", "FBgn0264895", "FBgn0264895" ] }, "reaction_10446848": { "compartment": "compartment_70101", "id": "reaction_10446848", "reactome": "R-DME-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444262", "species_10446844" ], "products": [ "species_10446846" ], "modifiers": [], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "P08645", "FBgn0004636", "species_29438" ] }, "reaction_10433100": { "compartment": "compartment_7660", "id": "reaction_10433100", "reactome": "R-DME-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10433097" ], "products": [ "species_113582", "species_10433093" ], "modifiers": [ [ "species_10433097", "catalyst" ] ], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10434824": { "compartment": "compartment_7660", "id": "reaction_10434824", "reactome": "R-DME-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433097" ], "products": [ "species_10433097" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10472491": { "compartment": "compartment_5460", "id": "reaction_10472491", "reactome": "R-DME-5419261", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472480", "species_10472487" ], "products": [ "species_10472489" ], "modifiers": [], "additional_components": [ "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VM33", "FBgn0263133", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VM33", "FBgn0263133" ] }, "reaction_10472506": { "compartment": "compartment_5460", "id": "reaction_10472506", "reactome": "R-DME-5419264", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472502", "species_113573", "species_10472493" ], "products": [ "species_10472504" ], "modifiers": [], "additional_components": [ "Q9VKU3", "FBgn0032261", "Q9VK20", "FBgn0032486", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VK20", "FBgn0032486" ] }, "reaction_10472535": { "compartment": "compartment_5460", "id": "reaction_10472535", "reactome": "R-DME-5419281", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472524", "species_10472510" ], "products": [ "species_10472533" ], "modifiers": [], "additional_components": [ "FBgn0035980", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "Q9VSW4", "FBgn0035980", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555" ] }, "reaction_10472531": { "compartment": "compartment_5460", "id": "reaction_10472531", "reactome": "R-DME-5419273", "name": "Hydrolysis of GTP and dissociation of 28S and 39S subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472526" ], "products": [ "species_10472528", "species_113548", "species_10472216", "species_10472474", "species_10472524" ], "modifiers": [ [ "species_10472526", "catalyst" ] ], "additional_components": [ "Q9VSW4", "FBgn0035980", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472504" ], "products": [ "species_113548", "species_10472502", "species_5419287", "species_113525", "species_10472510" ], "modifiers": [], "additional_components": [ "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VK20", "FBgn0032486", "Q9VKU3", "FBgn0032261", "Q9VK20", "FBgn0032486", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555" ] }, "reaction_10497334": { "compartment": "compartment_17947", "id": "reaction_10497334", "reactome": "R-DME-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497318" ], "products": [ "species_10446324", "species_10497332", "species_10446302" ], "modifiers": [], "additional_components": [ "Q9VUL8", "FBgn0036484", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407", "FBgn0032407", "Q9VZD9", "FBgn0052250", "Q9VL02", "FBgn0005322", "B7YZT2", "FBgn0039969", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q7JZE1", "FBgn0034058", "Q7JRD4", "FBgn0033812", "Q7JUN3", "FBgn0039890", "Q9VPB8", "FBgn0037020", "Q9VQI6", "FBgn0031478", "FBgn0036484" ] }, "reaction_10497336": { "compartment": "compartment_17947", "id": "reaction_10497336", "reactome": "R-DME-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497316", "species_10446302" ], "products": [ "species_10497318" ], "modifiers": [], "additional_components": [ "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407", "FBgn0036484", "Q9VUL8", "FBgn0036484", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407" ] }, "reaction_10497338": { "compartment": "compartment_70101", "id": "reaction_10497338", "reactome": "R-DME-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446324", "species_10497314" ], "products": [ "species_10497316" ], "modifiers": [], "additional_components": [ "FBgn0032407", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407" ] }, "reaction_10497233": { "compartment": "compartment_70101", "id": "reaction_10497233", "reactome": "R-DME-9033509", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454130", "species_10497208" ], "products": [ "species_10497210" ], "modifiers": [], "additional_components": [ "FBgn0005632", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P55824", "FBgn0005632" ] }, "reaction_10497248": { "compartment": "compartment_17951", "id": "reaction_10497248", "reactome": "R-DME-9033520", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_10497187" ], "products": [ "species_10497245", "species_10497243" ], "modifiers": [ [ "species_10497187", "catalyst" ] ], "additional_components": [ "FBgn0035065", "FBgn0035065", "FBgn0035065", "FBgn0035065" ] }, "reaction_10497250": { "compartment": "compartment_17947", "id": "reaction_10497250", "reactome": "R-DME-9033527", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497197", "species_10495029" ], "products": [ "species_10497199" ], "modifiers": [], "additional_components": [ "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497204": { "compartment": "compartment_17947", "id": "reaction_10497204", "reactome": "R-DME-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497199" ], "products": [ "species_10427563", "species_10497201" ], "modifiers": [ [ "species_10497199", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497191": { "compartment": "compartment_17947", "id": "reaction_10497191", "reactome": "R-DME-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497173" ], "products": [ "species_10497189", "species_10495027" ], "modifiers": [], "additional_components": [ "Q7KML2", "FBgn0027572", "Q9VRJ4", "FBgn0035588", "Q27571", "FBgn0011676", "Q7JZB1", "FBgn0033543", "Q9VM80", "FBgn0031860", "Q9V492", "FBgn0039930", "A1Z8D3", "FBgn0061356", "Q9W2G8", "FBgn0034629", "Q9W2G9", "FBgn0034628", "Q9W3U0", "FBgn0029924", "Q9W106", "FBgn0035065", "B7Z028", "FBgn0031813", "B7Z0E0", "FBgn0001248", "Q9VXJ0", "FBgn0030731", "Q8SXR7", "FBgn0034999", "E1JHE4", "FBgn0267828", "Q7KVJ6", "FBgn0265187", "Q9W5W8", "FBgn0031092", "Q9W3Z3", "FBgn0014031", "Q7K3B7", "FBgn0034488", "Q9VHN8", "FBgn0037606", "Q9VIK0", "FBgn0032881", "Q9VM58", "FBgn0031877", "Q9VEM4", "FBgn0038486", "Q9VB02", "FBgn0039543", "P22817", "FBgn0001247", "P17336", "FBgn0000261", "Q9VIV6", "FBgn0032790", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VIV6", "FBgn0032790", "Q9V492", "FBgn0039930", "Q9VXJ0", "FBgn0030731", "Q9W106", "FBgn0035065", "B7Z0E0", "FBgn0001248", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999", "A1Z8D3", "FBgn0061356", "Q9VM80", "FBgn0031860", "Q7JZB1", "FBgn0033543", "Q9VHN8", "FBgn0037606", "Q9W5W8", "FBgn0031092", "Q9VEM4", "FBgn0038486", "Q9VIK0", "FBgn0032881", "Q9W3Z3", "FBgn0014031", "Q9VM58", "FBgn0031877", "P22817", "FBgn0001247", "Q7K3B7", "FBgn0034488", "P17336", "FBgn0000261", "B7Z028", "FBgn0031813", "Q9VRJ4", "FBgn0035588", "Q9VB02", "FBgn0039543", "Q27571", "FBgn0011676", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497193": { "compartment": "compartment_17947", "id": "reaction_10497193", "reactome": "R-DME-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497171", "species_10497169" ], "products": [ "species_10497173" ], "modifiers": [], "additional_components": [ "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q7KML2", "FBgn0027572", "Q9VRJ4", "FBgn0035588", "Q27571", "FBgn0011676", "Q7JZB1", "FBgn0033543", "Q9VM80", "FBgn0031860", "Q9V492", "FBgn0039930", "A1Z8D3", "FBgn0061356", "Q9W2G8", "FBgn0034629", "Q9W2G9", "FBgn0034628", "Q9W3U0", "FBgn0029924", "Q9W106", "FBgn0035065", "B7Z028", "FBgn0031813", "B7Z0E0", "FBgn0001248", "Q9VXJ0", "FBgn0030731", "Q8SXR7", "FBgn0034999", "E1JHE4", "FBgn0267828", "Q7KVJ6", "FBgn0265187", "Q9W5W8", "FBgn0031092", "Q9W3Z3", "FBgn0014031", "Q7K3B7", "FBgn0034488", "Q9VHN8", "FBgn0037606", "Q9VIK0", "FBgn0032881", "Q9VM58", "FBgn0031877", "Q9VEM4", "FBgn0038486", "Q9VB02", "FBgn0039543", "P22817", "FBgn0001247", "P17336", "FBgn0000261", "Q9VIV6", "FBgn0032790", "O46085", "FBgn0023516", "Q7KML2", "FBgn0027572", "Q9VRJ4", "FBgn0035588", "Q27571", "FBgn0011676", "Q7JZB1", "FBgn0033543", "Q9VM80", "FBgn0031860", "Q9V492", "FBgn0039930", "A1Z8D3", "FBgn0061356", "Q9W2G8", "FBgn0034629", "Q9W2G9", "FBgn0034628", "Q9W3U0", "FBgn0029924", "Q9W106", "FBgn0035065", "B7Z028", "FBgn0031813", "B7Z0E0", "FBgn0001248", "Q9VXJ0", "FBgn0030731", "Q8SXR7", "FBgn0034999", "E1JHE4", "FBgn0267828", "Q7KVJ6", "FBgn0265187", "Q9W5W8", "FBgn0031092", "Q9W3Z3", "FBgn0014031", "Q7K3B7", "FBgn0034488", "Q9VHN8", "FBgn0037606", "Q9VIK0", "FBgn0032881", "Q9VM58", "FBgn0031877", "Q9VEM4", "FBgn0038486", "Q9VB02", "FBgn0039543", "P22817", "FBgn0001247", "P17336", "FBgn0000261", "Q9VIV6", "FBgn0032790", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497241": { "compartment": "compartment_17947", "id": "reaction_10497241", "reactome": "R-DME-9033514", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497237" ], "products": [ "species_10497197", "species_10497239" ], "modifiers": [], "additional_components": [ "Q9VSN7", "FBgn0035922", "Q9V778", "FBgn0033983", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "FBgn0033983" ] }, "reaction_10497213": { "compartment": "compartment_70101", "id": "reaction_10497213", "reactome": "R-DME-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10497210" ], "products": [ "species_10497167", "species_10454130", "species_10426987" ], "modifiers": [ [ "species_10497210", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P55824", "FBgn0005632", "FBgn0023516", "FBgn0005632", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P55824", "FBgn0005632" ] }, "reaction_10497087": { "compartment": "compartment_70101", "id": "reaction_10497087", "reactome": "R-DME-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497083", "species_10497078" ], "products": [ "species_10497085" ], "modifiers": [], "additional_components": [ "FBgn0033983", "FBgn0035922", "Q9VSN7", "FBgn0035922", "Q9V778", "FBgn0033983" ] }, "reaction_10497622": { "compartment": "compartment_70101", "id": "reaction_10497622", "reactome": "R-DME-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497405", "species_10497618" ], "products": [ "species_10497620" ], "modifiers": [], "additional_components": [ "Q9VJD4", "FBgn0032640", "P14599", "FBgn0000108", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P14599", "FBgn0000108", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9VJD4", "FBgn0032640" ] }, "reaction_10497453": { "compartment": "compartment_70101", "id": "reaction_10497453", "reactome": "R-DME-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497405", "species_10497449" ], "products": [ "species_10497451" ], "modifiers": [], "additional_components": [ "Q9VJD4", "FBgn0032640", "Q24509", "FBgn0011708", "Q7JZN0", "FBgn0010638", "Q9V4N3", "FBgn0264294", "Q9VJC0", "FBgn0032652", "Q9VUZ3", "FBgn0036575", "Q8IRR0", "FBgn0029854", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9VWE9", "FBgn0031049", "Q9VGJ9", "FBgn0037933", "Q8SYY6", "FBgn0047135", "Q9VEJ4", "FBgn0038515", "B7Z0E5", "FBgn0266757", "Q24547", "FBgn0013343", "Q24509", "FBgn0011708", "Q7JZN0", "FBgn0010638", "Q9V4N3", "FBgn0264294", "Q9VJC0", "FBgn0032652", "Q9VUZ3", "FBgn0036575", "Q8IRR0", "FBgn0029854", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9VWE9", "FBgn0031049", "Q9VGJ9", "FBgn0037933", "Q8SYY6", "FBgn0047135", "Q9VEJ4", "FBgn0038515", "B7Z0E5", "FBgn0266757", "Q24547", "FBgn0013343", "Q9VJD4", "FBgn0032640" ] }, "reaction_10495803": { "compartment": "compartment_5460", "id": "reaction_10495803", "reactome": "R-DME-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495795" ], "products": [], "modifiers": [ [ "species_10495800", "catalyst" ] ], "additional_components": [ "Q9W3X7", "FBgn0029888", "FBgn0033005" ] }, "reaction_10462211": { "compartment": "compartment_70616", "id": "reaction_10462211", "reactome": "R-DME-1955380", "name": "TIMM9:TIMM10 transfers proteins to TIMM22", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462198", "species_10462173", "species_10462205" ], "products": [ "species_10462209" ], "modifiers": [], "additional_components": [ "Q26365", "FBgn0003360", "Q9W2D6", "FBgn0027360", "Q9VYD7", "FBgn0030480", "FBgn0051229", "FBgn0027358", "Q9Y0V3", "FBgn0027358", "Q9W2D6", "FBgn0027360", "Q9VYD7", "FBgn0030480", "Q8IN78", "FBgn0051229", "Q26365", "FBgn0003360" ] }, "reaction_10471823": { "compartment": "compartment_70101", "id": "reaction_10471823", "reactome": "R-DME-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10471803" ], "products": [ "species_353106", "species_10471790" ], "modifiers": [ [ "species_10471820", "catalyst" ] ], "additional_components": [ "FBgn0000559", "FBgn0000559", "Q9VGQ9", "FBgn0037883", "Q9VFE9", "FBgn0038272", "Q9VTM2", "FBgn0036194" ] }, "reaction_10471787": { "compartment": "compartment_70101", "id": "reaction_10471787", "reactome": "R-DME-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471779", "species_113592", "species_31633" ], "products": [ "species_111294", "species_10435612", "species_76577" ], "modifiers": [ [ "species_10471784", "catalyst" ] ], "additional_components": [ "FBgn0000559", "FBgn0000559", "FBgn0030336" ] }, "reaction_10471801": { "compartment": "compartment_70101", "id": "reaction_10471801", "reactome": "R-DME-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10471790" ], "products": [ "species_10471793", "species_71285" ], "modifiers": [ [ "species_10471798", "catalyst" ] ], "additional_components": [ "FBgn0000559", "FBgn0000559", "FBgn0024558" ] }, "reaction_10479423": { "compartment": "compartment_70101", "id": "reaction_10479423", "reactome": "R-DME-6782628", "name": "USP8 deubiquitinates STAM2:HGS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479418" ], "products": [ "species_10426987", "species_10479420" ], "modifiers": [ [ "species_10479418", "catalyst" ] ], "additional_components": [ "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VDD8", "FBgn0038862", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VDD8", "FBgn0038862", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VDD8", "FBgn0038862" ] }, "reaction_10479326": { "compartment": "compartment_70101", "id": "reaction_10479326", "reactome": "R-DME-6781899", "name": "USP13 binds SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479271", "species_10444782" ], "products": [ "species_10479324" ], "modifiers": [], "additional_components": [ "FBgn0035402", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q9VZU7", "FBgn0035402" ] }, "reaction_10477596": { "compartment": "compartment_7660", "id": "reaction_10477596", "reactome": "R-DME-5690080", "name": "USP3,SAGA deubiquitinate Histone H2A,H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477591" ], "products": [ "species_10427430", "species_10477593" ], "modifiers": [ [ "species_10477591", "catalyst" ] ], "additional_components": [ "Q27272", "FBgn0000617", "M9PHZ1", "FBgn0030891", "Q9XZT7", "FBgn0026324", "Q8I8V0", "FBgn0037555", "Q9VVR1", "FBgn0013717", "Q9VTZ1", "FBgn0020388", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q27272", "FBgn0000617", "M9PHZ1", "FBgn0030891", "Q9XZT7", "FBgn0026324", "Q8I8V0", "FBgn0037555", "Q9VVR1", "FBgn0013717", "Q9VTZ1", "FBgn0020388", "Q27272", "FBgn0000617", "M9PHZ1", "FBgn0030891", "Q9XZT7", "FBgn0026324", "Q8I8V0", "FBgn0037555", "Q9VVR1", "FBgn0013717", "Q9VTZ1", "FBgn0020388" ] }, "reaction_10477625": { "compartment": "compartment_70101", "id": "reaction_10477625", "reactome": "R-DME-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477618", "species_29356" ], "products": [ "species_10477620", "species_10477101" ], "modifiers": [ [ "species_10477618", "catalyst" ] ], "additional_components": [ "Q8IQ27", "FBgn0031187", "P83104", "FBgn0046689", "Q8IQ27", "FBgn0031187", "P83104", "FBgn0046689", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8IQ27", "FBgn0031187", "P83104", "FBgn0046689" ] }, "reaction_10477496": { "compartment": "compartment_7660", "id": "reaction_10477496", "reactome": "R-DME-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477261" ], "products": [ "species_10477267", "species_10477493" ], "modifiers": [ [ "species_10477261", "catalyst" ] ], "additional_components": [ "Q7KMQ6", "Pten", "Q95V55", "foxo", "Q8IMZ4", "FBgn0039044", "Q9VYQ8", "FBgn0030366", "Q7KMQ6", "Pten", "Q95V55", "foxo", "Q8IMZ4", "FBgn0039044", "Q9VYQ8", "FBgn0030366", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q7KMQ6", "Pten", "Q95V55", "foxo", "Q8IMZ4", "FBgn0039044", "Q9VYQ8", "FBgn0030366" ] }, "reaction_10477112": { "compartment": "compartment_70101", "id": "reaction_10477112", "reactome": "R-DME-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477108", "species_10475480" ], "products": [ "species_10477110" ], "modifiers": [], "additional_components": [ "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q9VKZ8", "Usp14" ] }, "reaction_10479189": { "compartment": "compartment_70101", "id": "reaction_10479189", "reactome": "R-DME-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479180" ], "products": [ "species_10479186", "species_10477101" ], "modifiers": [ [ "species_10479180", "catalyst" ] ], "additional_components": [ "Q9VRP5", "FBgn0260936", "Q9U1H8", "FBgn0029121", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q9VRP5", "FBgn0260936", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q9U1H8", "FBgn0029121", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRP5", "FBgn0260936", "Q9U1H8", "FBgn0029121", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10479220": { "compartment": "compartment_70101", "id": "reaction_10479220", "reactome": "R-DME-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479215" ], "products": [ "species_10479217", "species_10437507" ], "modifiers": [ [ "species_10479215", "catalyst" ] ], "additional_components": [ "P83104", "FBgn0046689", "Q9W3I9", "FBgn0265464", "Q8IPC5", "FBgn0032210", "P83104", "FBgn0046689", "Q9W3I9", "FBgn0265464", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P83104", "FBgn0046689", "Q9W3I9", "FBgn0265464", "Q8IPC5", "FBgn0032210" ] }, "reaction_10479281": { "compartment": "compartment_70101", "id": "reaction_10479281", "reactome": "R-DME-6781779", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479276" ], "products": [ "species_10437507", "species_10479278" ], "modifiers": [ [ "species_10479276", "catalyst" ] ], "additional_components": [ "Q9VCE1", "FBgn0264325", "Q9VZU7", "FBgn0035402", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402", "Q9VCE1", "FBgn0264325", "Q9VCE1", "FBgn0264325", "Q9VZU7", "FBgn0035402" ] }, "reaction_10477646": { "compartment": "compartment_70101", "id": "reaction_10477646", "reactome": "R-DME-5690196", "name": "USP8 deubiquitinates RNF128", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477637" ], "products": [ "species_10454480", "species_10477643" ], "modifiers": [ [ "species_10477637", "catalyst" ] ], "additional_components": [ "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q9VDD8", "FBgn0038862", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q9VDD8", "FBgn0038862", "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q9VDD8", "FBgn0038862" ] }, "reaction_10479438": { "compartment": "compartment_7660", "id": "reaction_10479438", "reactome": "R-DME-6782820", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479431" ], "products": [ "species_10477395", "species_10479435" ], "modifiers": [ [ "species_10479431", "catalyst" ] ], "additional_components": [ "Q9VRP5", "FBgn0260936", "Q9VWG2", "FBgn0031036", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9VRP5", "FBgn0260936", "Q9VWG2", "FBgn0031036", "Q9VRP5", "FBgn0260936", "Q9VWG2", "FBgn0031036" ] }, "reaction_10477515": { "compartment": "compartment_7660", "id": "reaction_10477515", "reactome": "R-DME-5689973", "name": "USP10,USP24,USP42 deubiquitinate TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477510" ], "products": [ "species_10477493", "species_10477512" ], "modifiers": [ [ "species_10477510", "catalyst" ] ], "additional_components": [ "Q7JQI1", "FBgn0033738", "Q9VRP5", "FBgn0260936", "Q8IMZ4", "FBgn0039044", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q7JQI1", "FBgn0033738", "Q9VRP5", "FBgn0260936", "Q8IMZ4", "FBgn0039044", "Q7JQI1", "FBgn0033738", "Q9VRP5", "FBgn0260936", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10479211": { "compartment": "compartment_7660", "id": "reaction_10479211", "reactome": "R-DME-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479206" ], "products": [ "species_10477493", "species_10479208" ], "modifiers": [ [ "species_10479206", "catalyst" ] ], "additional_components": [ "Q8WS79", "FBgn0035849", "Q9VBC4", "FBgn0039451", "Q9VCT9", "FBgn0039025", "Q1LZ08", "FBgn0033607", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q8WS79", "FBgn0035849", "Q9VBC4", "FBgn0039451", "Q9VCT9", "FBgn0039025", "Q1LZ08", "FBgn0033607", "Q8WS79", "FBgn0035849", "Q9VBC4", "FBgn0039451", "Q9VCT9", "FBgn0039025", "Q1LZ08", "FBgn0033607" ] }, "reaction_10477608": { "compartment": "compartment_70101", "id": "reaction_10477608", "reactome": "R-DME-5690152", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477603" ], "products": [ "species_10477605", "species_10426987" ], "modifiers": [ [ "species_10477603", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402" ] }, "reaction_10479269": { "compartment": "compartment_7660", "id": "reaction_10479269", "reactome": "R-DME-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479262" ], "products": [ "species_10479266", "species_10477493" ], "modifiers": [ [ "species_10479262", "catalyst" ] ], "additional_components": [ "O18413", "Rpt6", "Q9VH07", "FBgn0040078", "P14785", "FBgn0000404", "Q9VZP3", "FBgn0010317", "O18413", "Rpt6", "Q9VH07", "FBgn0040078", "P14785", "FBgn0000404", "Q9VZP3", "FBgn0010317", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "O18413", "Rpt6", "Q9VH07", "FBgn0040078", "P14785", "FBgn0000404", "Q9VZP3", "FBgn0010317" ] }, "reaction_10479459": { "compartment": "compartment_7660", "id": "reaction_10479459", "reactome": "R-DME-6783177", "name": "USP21 deubiquitinates GATA3,IL33", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479454" ], "products": [ "species_10479456", "species_10477493" ], "modifiers": [ [ "species_10479454", "catalyst" ] ], "additional_components": [ "Q9VKZ0", "FBgn0032223", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q8IQ27", "FBgn0031187", "Q8IQ27", "FBgn0031187", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9VKZ0", "FBgn0032223", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q8IQ27", "FBgn0031187" ] }, "reaction_10479557": { "compartment": "compartment_70101", "id": "reaction_10479557", "reactome": "R-DME-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718" ], "products": [ "species_10457720" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10479555": { "compartment": "compartment_70101", "id": "reaction_10479555", "reactome": "R-DME-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457720" ], "products": [ "species_10457732" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10454317": { "compartment": "compartment_5460", "id": "reaction_10454317", "reactome": "R-DME-888548", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_880046", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113536" ], "modifiers": [ [ "species_10454314", "catalyst" ] ], "additional_components": [ "Q9VBP6", "FBgn0039349" ] }, "reaction_10454932": { "compartment": "compartment_5460", "id": "reaction_10454932", "reactome": "R-DME-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_916850", "species_113594" ], "products": [ "species_880046", "species_113552" ], "modifiers": [ [ "species_10454929", "catalyst" ] ], "additional_components": [ "Q9VW68", "FBgn0036927", "CHEBI:33739" ] }, "reaction_10457567": { "compartment": "compartment_7660", "id": "reaction_10457567", "reactome": "R-DME-997263", "name": "JMJD1C demethylates H3K9 mono- and di-methylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457547" ], "products": [ "species_10457559" ], "modifiers": [ [ "species_10457564", "catalyst" ] ], "additional_components": [ "P02299", "FBgn0001199", "C0HL67", "FBgn0004828", "C0HL66", "FBgn0014857", "P02299", "FBgn0001199", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "FBgn0037703" ] }, "reaction_10457532": { "compartment": "compartment_7660", "id": "reaction_10457532", "reactome": "R-DME-996755", "name": "ZFPM proteins bind GATA proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457477", "species_10457528" ], "products": [ "species_10457530" ], "modifiers": [], "additional_components": [ "FBgn0003963", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "P52168", "FBgn0003117", "Q9VF00", "FBgn0038391", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "P52168", "FBgn0003117", "Q9VF00", "FBgn0038391", "Q9VPQ6", "FBgn0003963" ] }, "reaction_10457401": { "compartment": "compartment_70101", "id": "reaction_10457401", "reactome": "R-DME-992708", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434305", "species_10457397" ], "products": [ "species_10457399" ], "modifiers": [], "additional_components": [ "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "Q7KVW1", "FBgn0263987", "Q9V3I3", "FBgn0040079", "Q7KVW1", "FBgn0263987", "Q9V3I3", "FBgn0040079", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243" ] }, "reaction_10457385": { "compartment": "compartment_17906", "id": "reaction_10457385", "reactome": "R-DME-992703", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457381" ], "products": [ "species_10457383" ], "modifiers": [], "additional_components": [ "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596" ] }, "reaction_10457432": { "compartment": "compartment_7660", "id": "reaction_10457432", "reactome": "R-DME-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457428", "species_10457406" ], "products": [ "species_10457430" ], "modifiers": [], "additional_components": [ "P02299", "FBgn0001199", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "FBgn0039019", "Q9VCU6", "FBgn0039019", "P02299", "FBgn0001199", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828" ] }, "reaction_10457637": { "compartment": "compartment_70101", "id": "reaction_10457637", "reactome": "R-DME-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457633", "species_10457631" ], "products": [ "species_10457635" ], "modifiers": [], "additional_components": [ "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "M9PCG3", "FBgn0260486", "Q9VPI9", "FBgn0031216", "M9PCG3", "FBgn0260486", "Q9VPI9", "FBgn0031216", "P40793", "FBgn0010341", "P40792", "RAC1_DROME" ] }, "reaction_10457604": { "compartment": "compartment_74700", "id": "reaction_10457604", "reactome": "R-DME-1011576", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457600", "species_10457591" ], "products": [ "species_10457602" ], "modifiers": [], "additional_components": [ "FBgn0261064", "FBgn0016693", "Q8T8W3", "FBgn0016693", "Q9VLS5", "FBgn0261064" ] }, "reaction_10457586": { "compartment": "compartment_5460", "id": "reaction_10457586", "reactome": "R-DME-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113581", "species_113525" ], "modifiers": [ [ "species_10457583", "catalyst" ] ], "additional_components": [ "FBgn0042094" ] }, "reaction_10454176": { "compartment": "compartment_70101", "id": "reaction_10454176", "reactome": "R-DME-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454167", "species_10454172" ], "products": [ "species_10454174" ], "modifiers": [], "additional_components": [ "FBgn0034577", "FBgn0011570", "P48603", "FBgn0011570", "Q9W2N0", "FBgn0034577" ] }, "reaction_10457472": { "compartment": "compartment_7660", "id": "reaction_10457472", "reactome": "R-DME-996727", "name": "REST recruits the BHC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457446", "species_10457468" ], "products": [ "species_10457470" ], "modifiers": [], "additional_components": [ "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q94517", "HDAC1", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397", "Q94517", "HDAC1", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397" ] }, "reaction_10457648": { "compartment": "compartment_74700", "id": "reaction_10457648", "reactome": "R-DME-1011600", "name": "Rabenosyn-5 connects Rab5 to VPS-45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457600", "species_10457639", "species_10457644" ], "products": [ "species_10457646" ], "modifiers": [], "additional_components": [ "FBgn0261064", "FBgn0014010", "FBgn0261049", "Q9VHB5", "FBgn0261049", "Q9V3I2", "FBgn0014010", "Q9VLS5", "FBgn0261064" ] }, "reaction_10480078": { "compartment": "compartment_1222282", "id": "reaction_10480078", "reactome": "R-DME-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10480037", "catalyst" ] ], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_10480042": { "compartment": "compartment_21994", "id": "reaction_10480042", "reactome": "R-DME-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10480039", "catalyst" ] ], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_10489081": { "compartment": "compartment_984", "id": "reaction_10489081", "reactome": "R-DME-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_8855492" ], "products": [ "species_109276", "species_8855489" ], "modifiers": [ [ "species_10489078", "catalyst" ] ], "additional_components": [ "Q9VZZ4", "FBgn0011828", "CHEBI:55376" ] }, "reaction_10491978": { "compartment": "compartment_1222282", "id": "reaction_10491978", "reactome": "R-DME-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_1470067", "species_6789221" ], "products": [ "species_8933637", "species_1222475" ], "modifiers": [ [ "species_10480037", "catalyst" ] ], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_10480080": { "compartment": "compartment_21994", "id": "reaction_10480080", "reactome": "R-DME-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480037", "species_983438" ], "products": [ "species_10480039" ], "modifiers": [], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828", "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_209075": { "compartment": "compartment_876", "id": "reaction_209075", "reactome": "R-DME-209075", "name": "Destabilisation and degradation of AXN in the 'destruction complex'", "reversible": "false", "notes": "Axin (AXN) is now destabilised and is degraded by an unknown mechanism, possibly by a similar ubiquitin-mediated proteolysis responsible for cytoplasmic Armadillo (ARM) degradation.", "reactants": [ "species_206993" ], "products": [ "species_206837" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P54367", "CkIalpha", "O76324", "DCO", "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_209120": { "compartment": "compartment_70101", "id": "reaction_209120", "reactome": "R-DME-209120", "name": "Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR", "reversible": "false", "notes": "Phosphorylated Arrow (ARR) is recognised by Axin (AXN) which binds to it along with the rest of the 'destruction complex'. Dishevelled (DSH) is recruited to the cytoplasmic part of Frizzled (FZ/FZ2) and additionally forms an interaction with AXN. There is conjecture whether DSH first binds to AXN, helping to recruit it to the membrane, while the 'destruction complex' is free in the cytoplasm.", "reactants": [ "species_207028", "species_205749", "species_206613" ], "products": [ "species_206952" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209081": { "compartment": "compartment_70101", "id": "reaction_209081", "reactome": "R-DME-209081", "name": "Disassembly of the destabilised 'destruction complex'", "reversible": "false", "notes": "The destabilised 'destruction complex' disassembles into the cytoplasm. The cytoplasmic concentration of Axin (AXN) has now decreased.", "reactants": [ "species_206837" ], "products": [ "species_206938", "species_205716", "species_206613", "species_205749", "species_206581", "species_205729", "species_206210" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC" ] }, "reaction_209112": { "compartment": "compartment_70101", "id": "reaction_209112", "reactome": "R-DME-209112", "name": "Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM", "reversible": "false", "notes": "The binding of Dishevelled (DSH) to Axin (AXN) in the 'destruction complex' appears to inhibit the kinase Shaggy (SGG). As this component appears to be the main instigator in keeping the 'destruction complex' phosphorylated, it's inactivation means the protein phosphatase orthologue, PP2A, can dephosphorylate members of the 'destruction complex'. This results in a decreased binding affinity for Armadillo (ARM) by AXN and APC (APC/APC2). The now unphosphorylated ARM disassociates from the 'destruction complex' into the cytoplasm.", "reactants": [ "species_206952" ], "products": [ "species_205774", "species_29372", "species_206993" ], "modifiers": [ [ "species_206612", "catalyst" ] ], "additional_components": [ "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P51140", "phospho-dsh", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_209297": { "compartment": "compartment_7660", "id": "reaction_209297", "reactome": "R-DME-209297", "name": "PYGO binds to the LGS:ARM complex", "reversible": "false", "notes": "The now nuclear Legless:Armadillo (LGS:ARM) complex binds to the nuclear anchor Pygopus (PYGO).", "reactants": [ "species_205990", "species_206839" ], "products": [ "species_206851" ], "modifiers": [], "additional_components": [ "Q961D9", "LGS", "P18824", "arm", "Q961D9", "LGS", "P18824", "arm", "Q9V9W8", "PYGO" ] }, "reaction_209181": { "compartment": "compartment_7660", "id": "reaction_209181", "reactome": "R-DME-209181", "name": "ARM displaces GRO and binds to PAN which activates transcription", "reversible": "false", "notes": "Armadillo (ARM) in its complex binds to Pangolin (PAN) and transcription is now activated.", "reactants": [ "species_206798", "species_206851" ], "products": [ "species_206729", "species_205750" ], "modifiers": [], "additional_components": [ "P91943", "PAN", "P16371", "GRO", "Q961D9", "LGS", "P18824", "arm", "Q9V9W8", "PYGO", "Q961D9", "LGS", "P18824", "arm", "Q9V9W8", "PYGO", "P91943", "PAN" ] }, "reaction_10428700": { "compartment": "compartment_70101", "id": "reaction_10428700", "reactome": "R-DME-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10428697", "catalyst" ] ], "additional_components": [ "Q9VKJ0", "FBgn0040211", "species_111793" ] }, "reaction_10428678": { "compartment": "compartment_70101", "id": "reaction_10428678", "reactome": "R-DME-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29506" ], "products": [ "species_29404", "species_31365" ], "modifiers": [ [ "species_10428675", "catalyst" ] ], "additional_components": [ "Q9VY42", "FBgn0030558" ] }, "reaction_10428710": { "compartment": "compartment_70101", "id": "reaction_10428710", "reactome": "R-DME-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10428707", "catalyst" ] ], "additional_components": [ "species_29450", "Q9VHD2", "FBgn0037697" ] }, "reaction_10428690": { "compartment": "compartment_70101", "id": "reaction_10428690", "reactome": "R-DME-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10428687", "catalyst" ] ], "additional_components": [ "species_351595", "Q9VPF3", "FBgn0036992", "species_111793" ] }, "reaction_10428720": { "compartment": "compartment_70101", "id": "reaction_10428720", "reactome": "R-DME-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29666", "species_29586" ], "modifiers": [ [ "species_10428717", "catalyst" ] ], "additional_components": [ "Q9VZI8", "FBgn0016013" ] }, "reaction_10479117": { "compartment": "compartment_70101", "id": "reaction_10479117", "reactome": "R-DME-5696365", "name": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696361", "species_29356" ], "products": [ "species_29502", "species_29448", "species_5359061" ], "modifiers": [ [ "species_10479114", "catalyst" ] ], "additional_components": [ "Q9VXT7", "FBgn0030653" ] }, "reaction_10454396": { "compartment": "compartment_70101", "id": "reaction_10454396", "reactome": "R-DME-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_29432", "species_893599" ], "modifiers": [ [ "species_10454393", "catalyst" ] ], "additional_components": [ "Q8SXC2", "FBgn0037955" ] }, "reaction_10428667": { "compartment": "compartment_70101", "id": "reaction_10428667", "reactome": "R-DME-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10428664", "catalyst" ] ], "additional_components": [ "O76454", "FBgn0024841" ] }, "reaction_10428647": { "compartment": "compartment_70101", "id": "reaction_10428647", "reactome": "R-DME-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29502", "species_29368" ], "products": [ "species_71112", "species_29506" ], "modifiers": [ [ "species_10428644", "catalyst" ] ], "additional_components": [ "species_111793", "P17276", "FBgn0001208" ] }, "reaction_10428657": { "compartment": "compartment_70101", "id": "reaction_10428657", "reactome": "R-DME-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71129", "species_73473" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10428654", "catalyst" ] ], "additional_components": [ "Q9VSU6", "FBgn0035964" ] }, "reaction_10426910": { "compartment": "compartment_7660", "id": "reaction_10426910", "reactome": "R-DME-68611", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426899", "species_10426906" ], "products": [ "species_10426908" ], "modifiers": [], "additional_components": [ "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181", "FBgn0286788", "O16810", "FBgn0286788", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181" ] }, "reaction_10426892": { "compartment": "compartment_7660", "id": "reaction_10426892", "reactome": "R-DME-68603", "name": "Orc5 associates with Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426881", "species_10426888" ], "products": [ "species_10426890" ], "modifiers": [], "additional_components": [ "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "FBgn0015271", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654" ] }, "reaction_10426919": { "compartment": "compartment_7660", "id": "reaction_10426919", "reactome": "R-DME-68615", "name": "Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426915", "species_10426908" ], "products": [ "species_10426917" ], "modifiers": [], "additional_components": [ "FBgn0023180", "O16810", "FBgn0286788", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181", "Q24168", "FBgn0015270", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181" ] }, "reaction_10426901": { "compartment": "compartment_7660", "id": "reaction_10426901", "reactome": "R-DME-68610", "name": "Orc4 associates with Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426897", "species_10426890" ], "products": [ "species_10426899" ], "modifiers": [], "additional_components": [ "FBgn0023181", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181" ] }, "reaction_10426883": { "compartment": "compartment_7660", "id": "reaction_10426883", "reactome": "R-DME-68595", "name": "Orc3 associates with Orc2 constitutively bound at origins of replication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426872", "species_10426879" ], "products": [ "species_10426881" ], "modifiers": [], "additional_components": [ "FBgn0005654", "Q24168", "FBgn0015270", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654" ] }, "reaction_10432475": { "compartment": "compartment_7660", "id": "reaction_10432475", "reactome": "R-DME-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432463" ], "products": [ "species_10432471" ], "modifiers": [], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10432473": { "compartment": "compartment_7660", "id": "reaction_10432473", "reactome": "R-DME-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432471" ], "products": [ "species_10431434", "species_113541" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10432465": { "compartment": "compartment_7660", "id": "reaction_10432465", "reactome": "R-DME-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432459", "species_30595" ], "products": [ "species_10432463" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10437548": { "compartment": "compartment_5460", "id": "reaction_10437548", "reactome": "R-DME-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10437537" ], "products": [ "species_76633", "species_10437535" ], "modifiers": [ [ "species_10437545", "catalyst" ] ], "additional_components": [ "species_31649", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "species_113596", "FBgn0286783" ] }, "reaction_10436779": { "compartment": "compartment_70616", "id": "reaction_10436779", "reactome": "R-DME-164651", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10436150", "species_113529", "species_76633" ], "products": [ "species_73663", "species_10436148", "species_76633", "species_163953" ], "modifiers": [ [ "species_10436776", "catalyst" ] ], "additional_components": [ "CHEBI:38574", "P84029", "FBgn0284248", "CHEBI:38573", "P84029", "FBgn0284248", "Q9VRL0", "FBgn0035600", "Q9VFF0", "FBgn0038271", "Q9VXI6", "FBgn0030733", "Q9VQ29", "FBgn0021906", "Q9VVH5", "FBgn0036728", "A8Y535", "FBgn0260008", "P18935", "FBgn0013678", "Q9XY35", "FBgn0011227", "Q9VV75", "FBgn0250814" ] }, "reaction_10437540": { "compartment": "compartment_5460", "id": "reaction_10437540", "reactome": "R-DME-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31649", "species_10437535" ], "products": [ "species_10437537", "species_113596" ], "modifiers": [ [ "species_10437535", "catalyst" ] ], "additional_components": [ "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "species_113596", "species_31649", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "species_113596" ] }, "reaction_10436576": { "compartment": "compartment_70616", "id": "reaction_10436576", "reactome": "R-DME-163217", "name": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_113529", "species_29362" ], "products": [ "species_76633", "species_113526", "species_163953" ], "modifiers": [ [ "species_10436566", "catalyst" ], [ "species_10436572", "catalyst" ] ], "additional_components": [ "Q9VMU0", "FBgn0031684", "Q9VMI3", "FBgn0031771", "species_76629", "Q9VWI0", "FBgn0031021", "Q94511", "FBgn0017566", "Q9VQD7", "FBgn0031436", "Q9VX36", "FBgn0030853", "P18931", "FBgn0262952", "P18932", "FBgn0013684", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "P18929", "FBgn0013679", "FBgn0033086" ] }, "reaction_10440271": { "compartment": "compartment_70101", "id": "reaction_10440271", "reactome": "R-DME-193073", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176626", "species_29360" ], "products": [ "species_70106", "species_193079", "species_73473" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10440269": { "compartment": "compartment_70101", "id": "reaction_10440269", "reactome": "R-DME-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193079", "species_29364" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10440264", "catalyst" ] ], "additional_components": [ "FBgn0029975" ] }, "reaction_10498692": { "compartment": "compartment_70101", "id": "reaction_10498692", "reactome": "R-DME-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10469802", "catalyst" ] ], "additional_components": [ "FBgn0032014" ] }, "reaction_10443612": { "compartment": "compartment_876", "id": "reaction_10443612", "reactome": "R-DME-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443603", "species_10443588", "species_10443573", "species_10443608", "species_10443593", "species_10443578", "species_10443598", "species_10443583" ], "products": [ "species_10443610" ], "modifiers": [], "additional_components": [ "FBgn0266671", "FBgn0266674", "FBgn0266672", "FBgn0266667", "FBgn0266668", "FBgn0266670", "FBgn0266669", "FBgn0266673", "Q9XTM1", "FBgn0266673", "Q9VVG4", "FBgn0266669", "Q9VQQ9", "FBgn0266670", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VNH6", "FBgn0266672", "Q9VDE6", "FBgn0266674", "Q9V8K2", "FBgn0266671" ] }, "reaction_10490116": { "compartment": "compartment_70101", "id": "reaction_10490116", "reactome": "R-DME-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10490113", "catalyst" ] ], "additional_components": [ "FBgn0033463" ] }, "reaction_10490199": { "compartment": "compartment_70101", "id": "reaction_10490199", "reactome": "R-DME-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_8868393", "species_1806234" ], "modifiers": [ [ "species_10448907", "catalyst" ] ], "additional_components": [ "FBgn0020626" ] }, "reaction_10440382": { "compartment": "compartment_70101", "id": "reaction_10440382", "reactome": "R-DME-193766", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10440366": { "compartment": "compartment_70101", "id": "reaction_10440366", "reactome": "R-DME-193711", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10440380": { "compartment": "compartment_17951", "id": "reaction_10440380", "reactome": "R-DME-193763", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193793" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440378": { "compartment": "compartment_70101", "id": "reaction_10440378", "reactome": "R-DME-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440376": { "compartment": "compartment_70101", "id": "reaction_10440376", "reactome": "R-DME-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_193707", "species_29366" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440374": { "compartment": "compartment_70101", "id": "reaction_10440374", "reactome": "R-DME-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193724", "species_70106", "species_29364" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440372": { "compartment": "compartment_70101", "id": "reaction_10440372", "reactome": "R-DME-193743", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10440386": { "compartment": "compartment_70101", "id": "reaction_10440386", "reactome": "R-DME-193789", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192189", "species_29360" ], "products": [ "species_193724", "species_70106", "species_73473" ], "modifiers": [ [ "species_10440112", "catalyst" ] ], "additional_components": [ "FBgn0036698" ] }, "reaction_10440370": { "compartment": "compartment_17951", "id": "reaction_10440370", "reactome": "R-DME-193736", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440384": { "compartment": "compartment_70101", "id": "reaction_10440384", "reactome": "R-DME-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440368": { "compartment": "compartment_70101", "id": "reaction_10440368", "reactome": "R-DME-193727", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10457738": { "compartment": "compartment_70101", "id": "reaction_10457738", "reactome": "R-DME-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10434957", "species_74016" ], "products": [ "species_10434971" ], "modifiers": [], "additional_components": [ "P13677", "FBgn0004784", "P05130", "FBgn0003091", "species_114519", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "species_33625", "species_74016" ] }, "reaction_10457781": { "compartment": "compartment_70101", "id": "reaction_10457781", "reactome": "R-DME-1168633", "name": "NF-kappaB translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457765" ], "products": [ "species_10457779" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10457811": { "compartment": "compartment_70101", "id": "reaction_10457811", "reactome": "R-DME-1168640", "name": "Ubiquitinated IkB is degraded", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457809" ], "products": [ "species_10457765" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q03017", "phospho-cact", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10464584": { "compartment": "compartment_876", "id": "reaction_10464584", "reactome": "R-DME-2045911", "name": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_179838" ], "modifiers": [ [ "species_10464581", "catalyst" ] ], "additional_components": [ "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q9VFI0", "FBgn0020299" ] }, "reaction_10457751": { "compartment": "compartment_12045", "id": "reaction_10457751", "reactome": "R-DME-1168376", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457744" ], "products": [ "species_10457746", "species_74016" ], "modifiers": [ [ "species_10457748", "catalyst" ] ], "additional_components": [ "P83094", "Stim", "species_74016", "P83094", "Stim", "species_114520", "P29993", "FBgn0010051" ] }, "reaction_10464790": { "compartment": "compartment_876", "id": "reaction_10464790", "reactome": "R-DME-2076220", "name": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_179838" ], "modifiers": [ [ "species_10464787", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q08012", "FBgn0004638" ] }, "reaction_10464848": { "compartment": "compartment_12045", "id": "reaction_10464848", "reactome": "R-DME-2089927", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457746", "species_10464844" ], "products": [ "species_10464846" ], "modifiers": [], "additional_components": [ "P83094", "Stim", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "P83094", "Stim" ] }, "reaction_10458693": { "compartment": "compartment_876", "id": "reaction_10458693", "reactome": "R-DME-1296045", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458690", "catalyst" ] ], "additional_components": [ "B7YZX2", "FBgn0032706" ] }, "reaction_10458898": { "compartment": "compartment_876", "id": "reaction_10458898", "reactome": "R-DME-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458895", "catalyst" ] ], "additional_components": [ "Q94526", "FBgn0017561" ] }, "reaction_10456991": { "compartment": "compartment_17957", "id": "reaction_10456991", "reactome": "R-DME-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_983032" ], "products": [ "species_29372", "species_29370", "species_983034" ], "modifiers": [ [ "species_10456988", "catalyst" ] ], "additional_components": [ "Q9VRW2", "FBgn0035695", "Q5BI62", "FBgn0010241", "Q00748", "FBgn0004513", "Q00449", "FBgn0004512" ] }, "reaction_10457141": { "compartment": "compartment_17957", "id": "reaction_10457141", "reactome": "R-DME-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_8943716", "species_983033" ], "modifiers": [ [ "species_10457138", "catalyst" ] ], "additional_components": [ "Q9VJN2", "FBgn0028935", "Q0KI25", "FBgn0039064", "Q9VD87", "FBgn0038897", "Q0KI00", "FBgn0263236", "Q9VAM2", "FBgn0039656", "Q9W2S8", "FBgn0030222", "Q95SR0", "FBgn0051445", "Q9W2S7", "FBgn0030223", "Q8SWX4", "FBgn0051343", "Q9W1S1", "FBgn0046253", "Q8MRN5", "FBgn0051343", "Q9VTL4", "FBgn0036186", "Q8IRH1", "FBgn0261243" ] }, "reaction_10433208": { "compartment": "compartment_5460", "id": "reaction_10433208", "reactome": "R-DME-77327", "name": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77326", "species_113596" ], "products": [ "species_77324", "species_31649" ], "modifiers": [ [ "species_10433199", "catalyst" ] ], "additional_components": [ "Q9VDT1", "FBgn0038742" ] }, "reaction_10433206": { "compartment": "compartment_5460", "id": "reaction_10433206", "reactome": "R-DME-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77324", "species_113521" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433204": { "compartment": "compartment_5460", "id": "reaction_10433204", "reactome": "R-DME-77321", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77320" ], "products": [ "species_77318", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433212": { "compartment": "compartment_5460", "id": "reaction_10433212", "reactome": "R-DME-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433210": { "compartment": "compartment_5460", "id": "reaction_10433210", "reactome": "R-DME-77329", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77328" ], "products": [ "species_77326", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433222": { "compartment": "compartment_5460", "id": "reaction_10433222", "reactome": "R-DME-77338", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77337" ], "products": [ "species_77332", "species_31649" ], "modifiers": [ [ "species_10433219", "catalyst" ] ], "additional_components": [ "Q9VSA3", "FBgn0035811" ] }, "reaction_10433166": { "compartment": "compartment_5460", "id": "reaction_10433166", "reactome": "R-DME-77271", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77269" ], "products": [ "species_77261", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433172": { "compartment": "compartment_5460", "id": "reaction_10433172", "reactome": "R-DME-77283", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77276", "species_113526" ], "products": [ "species_113529", "species_77269", "species_29362" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433169": { "compartment": "compartment_5460", "id": "reaction_10433169", "reactome": "R-DME-77277", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77273", "species_113521" ], "products": [ "species_77276" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_210662": { "compartment": "compartment_70101", "id": "reaction_210662", "reactome": "R-DME-210662", "name": "Phosphorylated HOP is dephosphorylated by PTP61F isoform 1", "reversible": "false", "notes": "The Janus tyrosine kinase, Hopscotch (HOP) is dephosphorylated in the cytosol by the protein tyrosine phosphatase, PTP61F isoform 1.", "reactants": [ "species_206905" ], "products": [ "species_29372", "species_206753" ], "modifiers": [ [ "species_210628", "catalyst" ] ], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_210646": { "compartment": "compartment_70101", "id": "reaction_210646", "reactome": "R-DME-210646", "name": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1", "reversible": "false", "notes": "In the cytosol, phosphorylated STAT92E dimer is dephosphorylated on Tyr711 by the protein tyrosine phosphatase, PTP61F isoform 1.", "reactants": [ "species_207008" ], "products": [ "species_205965", "species_29372" ], "modifiers": [ [ "species_210628", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_210694": { "compartment": "compartment_7660", "id": "reaction_210694", "reactome": "R-DME-210694", "name": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2", "reversible": "false", "notes": "An alternative spliced form of the protein tyrosine phosphatase, PTP61FC (PTP61F isoform 2) is active in the nucleus and dephosphorylates the phosphorylated STAT92E dimer on Tyr711 resulting in its dissociation.", "reactants": [ "species_207031" ], "products": [ "species_113550", "species_206244" ], "modifiers": [ [ "species_210622", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_210687": { "compartment": "compartment_13231", "id": "reaction_210687", "reactome": "R-DME-210687", "name": "STAT92E transports from the nucleus to the cytosol", "reversible": "false", "notes": "Unphosphorylated STAT92E translocates from the nucleus to the cytosol.", "reactants": [ "species_206244" ], "products": [ "species_205965" ], "modifiers": [], "additional_components": [] }, "reaction_209307": { "compartment": "compartment_7660", "id": "reaction_209307", "reactome": "R-DME-209307", "name": "Phosphorylated STAT92E dimer activates transcription", "reversible": "false", "notes": "Once in the nucleus, the phosphorylated STAT92E dimer binds to a palindromic DNA sequence in the promoters of the pathway target genes. This now enables transcription to be activated.", "reactants": [ "species_207031" ], "products": [ "species_207031" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_209255": { "compartment": "compartment_984", "id": "reaction_209255", "reactome": "R-DME-209255", "name": "UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP", "reversible": "false", "notes": "The UPD (OS, UPD2, UPD3) family of ligands bind to the DOME:HOP dimer complex. Ligand binding suggests an induced conformational change in the DOME receptor that brings the HOP proteins, bound to the intracellular domains, closer together. The HOP tyrosine kinase is now activated.", "reactants": [ "species_206971", "species_206555" ], "products": [ "species_206753" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q9VWE0", "dome", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209336": { "compartment": "compartment_70101", "id": "reaction_209336", "reactome": "R-DME-209336", "name": "Activated HOP is autophosphorylated and/or transphosphorylated", "reversible": "false", "notes": "The activated HOPs phosphorylate themselves and each other. The precise residue position where this takes place is currently unknown as there are many potential phosphorylation sites on HOP.", "reactants": [ "species_113592", "species_206753" ], "products": [ "species_29370", "species_206905" ], "modifiers": [ [ "species_206753", "catalyst" ] ], "additional_components": [ "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209160": { "compartment": "compartment_70101", "id": "reaction_209160", "reactome": "R-DME-209160", "name": "Phosphorylated HOP phosphorylates DOME", "reversible": "false", "notes": "Tyr966 on the cytoplasmic tail of the DOME receptor is phosphorylated by phosphorylated HOP.", "reactants": [ "species_206905", "species_113592" ], "products": [ "species_206942", "species_29370" ], "modifiers": [ [ "species_206905", "catalyst" ] ], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome" ] }, "reaction_209231": { "compartment": "compartment_876", "id": "reaction_209231", "reactome": "R-DME-209231", "name": "DOME:HOP complex forms a dimer at the plasma membrane", "reversible": "false", "notes": "The HOP:DOME:DOME:HOP complex formation precedes ligand binding", "reactants": [ "species_206890" ], "products": [ "species_206971" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209245": { "compartment": "compartment_70101", "id": "reaction_209245", "reactome": "R-DME-209245", "name": "Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex", "reversible": "false", "notes": "The Domeless (DOME) cytokine receptor contains no tyrosine kinase domain. However, it is constitutively associated with the JAK tyrosine kinase, Hopscotch (HOP).", "reactants": [ "species_206172", "species_206271" ], "products": [ "species_206890" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209296": { "compartment": "compartment_7660", "id": "reaction_209296", "reactome": "R-DME-209296", "name": "SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription", "reversible": "false", "notes": "The negative pathway regulator SU(VAR)2-10 physically interacts with the phosphorylated STAT92E dimer and prevents it from binding to it's pathway target genes and so inhibiting transcription.SU(VAR)2-10 is a PIAS protein (protein inhibitors of activated STAT) and is also referred to as ZIMP protein.In vertebrates, PIAS proteins control the duration of JAK/STAT signalling by targeting active STAT for degradation by SUMOlation.", "reactants": [ "species_205759", "species_207031" ], "products": [ "species_206936" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E", "Q7KNF5", "SU(VAR)2-10" ] }, "reaction_210700": { "compartment": "compartment_7660", "id": "reaction_210700", "reactome": "R-DME-210700", "name": "KEN dimer represses transcription", "reversible": "false", "notes": "In the nucleus, the BCL6 orthologue, Ken and Barbie (KEN) dimer binds to GAAA sequences of the target gene DNA sequence. These overlap with some STAT92E binding sites and leads to transcription repression.", "reactants": [ "species_210679" ], "products": [ "species_210679" ], "modifiers": [], "additional_components": [ "O77459", "KEN", "O77459", "KEN" ] }, "reaction_209361": { "compartment": "compartment_70101", "id": "reaction_209361", "reactome": "R-DME-209361", "name": "STAT92E binds to phosphorylated HOP and phosphorylated DOME", "reversible": "false", "notes": "The phosphorylated residues on HOP and DOME form a docking site for the SH2 domains of STAT92E molecules and so a complex is formed involving these domains.", "reactants": [ "species_205965", "species_206942" ], "products": [ "species_206838" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E" ] }, "reaction_209365": { "compartment": "compartment_13231", "id": "reaction_209365", "reactome": "R-DME-209365", "name": "Phosphorylated STAT92E dimer transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated STAT92E dimer is translocated to the nucleus.", "reactants": [ "species_207008" ], "products": [ "species_207031" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_209210": { "compartment": "compartment_70101", "id": "reaction_209210", "reactome": "R-DME-209210", "name": "STAT92E is phosphorylated by phosphorylated HOP", "reversible": "false", "notes": "Tyr711 on STAT92E is phosphorylated by phosphorylated HOP tyrosine kinase.", "reactants": [ "species_113592", "species_206838" ], "products": [ "species_29370", "species_206806" ], "modifiers": [ [ "species_206838", "catalyst" ] ], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E", "Q24592", "phospho-hop", "Q24151", "Stat92E", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E" ] }, "reaction_209321": { "compartment": "compartment_70101", "id": "reaction_209321", "reactome": "R-DME-209321", "name": "Phosphorylated STAT92E dissociates from HOP and DOME and dimerises", "reversible": "false", "notes": "After STAT92E is phosphorylated, it dissociates from phosphorylated HOP and phosphorylated DOME or the receptor complex. The now free phosphorylated STAT92E forms a dimer with another phosphorylated STAT92E molecule. These dimers are stabilised by the interaction between the SH2 domain of one molecule and the phospho Tyr of the other.", "reactants": [ "species_206806" ], "products": [ "species_206942", "species_207008" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q24151", "Stat92E", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E" ] }, "reaction_10446644": { "compartment": "compartment_70101", "id": "reaction_10446644", "reactome": "R-DME-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10440775" ], "products": [ "species_29372", "species_10446639" ], "modifiers": [ [ "species_10440527", "catalyst" ] ], "additional_components": [] }, "reaction_10491859": { "compartment": "compartment_70101", "id": "reaction_10491859", "reactome": "R-DME-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10435578" ], "products": [ "species_10491851", "species_71285" ], "modifiers": [ [ "species_10491856", "catalyst" ] ], "additional_components": [ "P08736", "FBgn0284245", "P05303", "FBgn0000557", "P05303", "FBgn0000557", "P08736", "FBgn0284245", "FBgn0031777" ] }, "reaction_10491942": { "compartment": "compartment_70101", "id": "reaction_10491942", "reactome": "R-DME-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10435578" ], "products": [ "species_10491934", "species_71285" ], "modifiers": [ [ "species_10491939", "catalyst" ] ], "additional_components": [ "P08736", "FBgn0284245", "P05303", "FBgn0000557", "P05303", "FBgn0000557", "P08736", "FBgn0284245", "FBgn0031485" ] }, "reaction_10491880": { "compartment": "compartment_70101", "id": "reaction_10491880", "reactome": "R-DME-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10471517" ], "products": [ "species_71285", "species_10491872" ], "modifiers": [ [ "species_10491877", "catalyst" ] ], "additional_components": [ "FBgn0286784", "FBgn0286784", "FBgn0031003" ] }, "reaction_10491839": { "compartment": "compartment_70101", "id": "reaction_10491839", "reactome": "R-DME-8879123", "name": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10430268" ], "products": [ "species_10491831", "species_71285" ], "modifiers": [ [ "species_10491836", "catalyst" ] ], "additional_components": [ "FBgn0004867", "FBgn0004867", "FBgn0038306" ] }, "reaction_10490208": { "compartment": "compartment_876", "id": "reaction_10490208", "reactome": "R-DME-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461036", "species_10490194" ], "products": [ "species_10490201" ], "modifiers": [], "additional_components": [ "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10490368": { "compartment": "compartment_876", "id": "reaction_10490368", "reactome": "R-DME-8868661", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490203" ], "products": [ "species_29372", "species_10490359" ], "modifiers": [ [ "species_10490203", "catalyst" ] ], "additional_components": [ "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", 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"FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", 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"O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "Q7KLE5", "FBgn0027356", "P27619", "FBgn0003392", "species_29438", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772" ] }, "reaction_10489506": { "compartment": "compartment_876", "id": "reaction_10489506", "reactome": "R-DME-8862280", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489326", "species_10489339", "species_10489337", "species_10489331", "species_10439052", "species_10442542" ], "products": [ "species_10489341" ], "modifiers": [], "additional_components": [ "Q6AWD5", "FBgn0037702", "FBgn0037702", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "FBgn0032341", "FBgn0035060", "FBgn0023388", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q6AWD5", "FBgn0037702" ] }, "reaction_10490921": { "compartment": "compartment_24339", "id": "reaction_10490921", "reactome": "R-DME-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490919" ], "products": [ "species_10489311", "species_10490404" ], "modifiers": [], "additional_components": [ "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9V3I2", "FBgn0014010", "Q9VZ08", "FBgn0030286", "FBgn0015772", "Q9V3I2", "FBgn0014010", "species_29438", "Q9VZ08", "FBgn0030286", "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702" ] }, "reaction_10490923": { "compartment": "compartment_24339", "id": "reaction_10490923", "reactome": "R-DME-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490917", "species_10490352" ], "products": [ "species_10490919" ], "modifiers": [], "additional_components": [ "Q9V3I2", "FBgn0014010", "species_29420", "Q9VZ08", "FBgn0030286", "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9V3I2", "FBgn0014010", "Q9VZ08", "FBgn0030286" ] }, "reaction_10490925": { "compartment": "compartment_876", "id": "reaction_10490925", "reactome": "R-DME-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469475", "species_10447882", "species_179856" ], "products": [ "species_10489337" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10489357": { "compartment": "compartment_876", "id": "reaction_10489357", "reactome": "R-DME-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489311", "species_10489341", "species_10469475", "species_10447882", "species_10489347" ], "products": [ "species_10489349" ], "modifiers": [ [ "species_10489355", "catalyst" ] ], "additional_components": [ "FBgn0015772", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q6AWD5", "FBgn0037702", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9VXB0", "FBgn0030791", "Q9VXB0", "FBgn0030791", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9VTX5", "FBgn0020655", "P40946", "FBgn0013750", "species_29438" ] }, "reaction_10490190": { "compartment": "compartment_876", "id": "reaction_10490190", "reactome": "R-DME-8868230", "name": "SNX9 recruits components of the actin polymerizing machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490175", "species_10490171", "species_10490186", "species_10490184", "species_10469463", "species_10490179" ], "products": [ "species_10490188" ], "modifiers": [], "additional_components": [ "Q8MQJ8", "FBgn0036309", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "species_113592", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q8MQJ8", "FBgn0036309", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475" ] }, "reaction_10490130": { "compartment": "compartment_876", "id": "reaction_10490130", "reactome": "R-DME-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490118", "species_10489365" ], "products": [ "species_10490120" ], "modifiers": [], "additional_components": [ "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10490196": { "compartment": "compartment_876", "id": "reaction_10490196", "reactome": "R-DME-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490188", "species_10490192" ], "products": [ "species_10490194" ], "modifiers": [], "additional_components": [ "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "P27619", "FBgn0003392", "species_29438", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475" ] }, "reaction_10490133": { "compartment": "compartment_876", "id": "reaction_10490133", "reactome": "R-DME-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10447052", "catalyst" ] ], "additional_components": [ "FBgn0034789" ] }, "reaction_10490357": { "compartment": "compartment_24339", "id": "reaction_10490357", "reactome": "R-DME-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490350", "species_29356" ], "products": [ "species_29372", "species_10490354", "species_10490352" ], "modifiers": [ [ "species_10490350", "catalyst" ] ], "additional_components": [ "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490120", "species_10461053" ], "products": [ "species_10490122" ], "modifiers": [], "additional_components": [ "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "FBgn0015278", "Q7K3H0", "FBgn0015278", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10489368": { "compartment": "compartment_876", "id": "reaction_10489368", "reactome": "R-DME-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10489349" ], "products": [ "species_29370", "species_10489365" ], "modifiers": [ [ "species_10489349", "catalyst" ] ], "additional_components": [ "Q9VXB0", "FBgn0030791", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9VXB0", "FBgn0030791", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772" ] }, "reaction_10490138": { "compartment": "compartment_876", "id": "reaction_10490138", "reactome": "R-DME-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10490122", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10490363": { "compartment": "compartment_24339", "id": "reaction_10490363", "reactome": "R-DME-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490359", "species_10447997" ], "products": [ "species_10490361" ], "modifiers": [], "additional_components": [ "P27619", "FBgn0003392", "species_29420", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "FBgn0037218", "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q8MQJ8", "FBgn0036309", "Q9VMY8", "FBgn0037218", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9VJ30", "FBgn0015772" ] }, "reaction_10490365": { "compartment": "compartment_24339", "id": "reaction_10490365", "reactome": "R-DME-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471267", "species_10490361" ], "products": [ "species_10490350" ], "modifiers": [], "additional_components": [ "P11147", "FBgn0266599", "species_113592", "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q8MQJ8", "FBgn0036309", "Q9VMY8", "FBgn0037218", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9VJ30", "FBgn0015772", "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q8MQJ8", "FBgn0036309", "Q9VMY8", "FBgn0037218", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "P11147", "FBgn0266599", "Q9VJ30", "FBgn0015772" ] }, "reaction_10490206": { "compartment": "compartment_876", "id": "reaction_10490206", "reactome": "R-DME-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490201" ], "products": [ "species_29372", "species_10490203" ], "modifiers": [ [ "species_10490201", "catalyst" ] ], "additional_components": [ "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", 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"FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "Q7KLE5", "FBgn0027356", "P27619", "FBgn0003392", "species_29438", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10439917": { "compartment": "compartment_70101", "id": "reaction_10439917", "reactome": "R-DME-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439913" ], "products": [], "modifiers": [], "additional_components": [ "P98081", "FBgn0000414", "O62530", "FBgn0263351", "Q01989", "FBgn0011225" ] }, "reaction_10439915": { "compartment": "compartment_876", "id": "reaction_10439915", "reactome": "R-DME-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439857", "species_10439852" ], "products": [ "species_10439913" ], "modifiers": [], "additional_components": [ "FBgn0011225", "P98081", "FBgn0000414", "O62530", "FBgn0263351", "P98081", "FBgn0000414", "O62530", "FBgn0263351", "Q01989", "FBgn0011225" ] }, "reaction_10440628": { "compartment": "compartment_876", "id": "reaction_10440628", "reactome": "R-DME-196026", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439834", "species_10439839" ], "products": [ "species_10439841" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "FBgn0000414", "P98081", "FBgn0000414", "O62530", "FBgn0263351" ] }, "reaction_10440626": { "compartment": "compartment_876", "id": "reaction_10440626", "reactome": "R-DME-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439841", "species_10439850" ], "products": [ "species_10439852" ], "modifiers": [], "additional_components": [ "P98081", "FBgn0000414", "O62530", "FBgn0263351", "P98081", "FBgn0000414", "O62530", "FBgn0263351" ] }, "reaction_10486354": { "compartment": "compartment_6791047", "id": "reaction_10486354", "reactome": "R-DME-6807866", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486350", "species_10486342" ], "products": [ "species_10486352" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29420", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10486755": { "compartment": "compartment_20699", "id": "reaction_10486755", "reactome": "R-DME-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10486749", "species_10478727" ], "products": [ "species_10486753" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "Q9W3M8", "FBgn0260858", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9W3M8", "FBgn0260858", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "Q23983", "FBgn0250791" ] }, "reaction_10486564": { "compartment": "compartment_6791047", "id": "reaction_10486564", "reactome": "R-DME-6807877", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486475" ], "products": [ "species_10486350", "species_10486421", "species_10486340", "species_10486561" ], "modifiers": [ [ "species_10486475", "catalyst" ] ], "additional_components": [ "Q0KIE7", "FBgn0011747", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9W3M8", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "P40945", "FBgn0013749", "species_29420", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "FBgn0264560", "Q0KIE7", "FBgn0011747", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9W3N6", "FBgn0040087", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VVX6", "FBgn0260857", "O76767", "FBgn0267330", "Q9W3M8", "FBgn0260858", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q0KIE7", "FBgn0011747", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9W3M8", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789" ] }, "reaction_10486407": { "compartment": "compartment_6791047", "id": "reaction_10486407", "reactome": "R-DME-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486358", "species_10486403" ], "products": [ "species_10486405" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087" ] }, "reaction_10486344": { "compartment": "compartment_6791047", "id": "reaction_10486344", "reactome": "R-DME-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478691", "species_10486340", "species_10486338" ], "products": [ "species_10486342" ], "modifiers": [], "additional_components": [ "Q9W3N6", "FBgn0040087", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087" ] }, "reaction_10486361": { "compartment": "compartment_6791047", "id": "reaction_10486361", "reactome": "R-DME-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10486352" ], "products": [ "species_29370", "species_10486358" ], "modifiers": [ [ "species_10486352", "catalyst" ] ], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "P40945", "FBgn0013749", "species_29420", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10486587": { "compartment": "compartment_432051", "id": "reaction_10486587", "reactome": "R-DME-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473488", "species_10486561" ], "products": [ "species_10486585" ], "modifiers": [], "additional_components": [ "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420", "Q0KIE7", "FBgn0011747", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9W3N6", "FBgn0040087", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VVX6", "FBgn0260857", "O76767", "FBgn0267330", "Q9W3M8", "FBgn0260858", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q0KIE7", "FBgn0011747", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9W3N6", "FBgn0040087", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VVX6", "FBgn0260857", "O76767", "FBgn0267330", "Q9W3M8", "FBgn0260858", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29420" ] }, "reaction_10486477": { "compartment": "compartment_6791047", "id": "reaction_10486477", "reactome": "R-DME-6807875", "name": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486473", "species_10478762", "species_10486421", "species_10486405", "species_10486467", "species_10486450", "species_10449902" ], "products": [ "species_10486475" ], "modifiers": [], "additional_components": [ "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "FBgn0011747", "Q0KIE7", "FBgn0011747", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9W3M8", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789" ] }, "reaction_10486751": { "compartment": "compartment_20699", "id": "reaction_10486751", "reactome": "R-DME-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486730", "species_10486745" ], "products": [ "species_10486747" ], "modifiers": [], "additional_components": [ "Q9VMD2", "FBgn0031818", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "Q0KIE7", "FBgn0011747", "Q9W3M8", "FBgn0260858", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W3N6", "FBgn0040087", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "Q9VMD2", "FBgn0031818", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "Q0KIE7", "FBgn0011747", "Q9W3M8", "FBgn0260858", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W3N6", "FBgn0040087", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401" ] }, "reaction_10478860": { "compartment": "compartment_12045", "id": "reaction_10478860", "reactome": "R-DME-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478856", "species_10478844" ], "products": [ "species_10478858" ], "modifiers": [], "additional_components": [ "Q9V3A8", "FBgn0035909", "Q7JYA0", "FBgn0033873", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q7JYA0", "FBgn0033873", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3A8", "FBgn0035909" ] }, "reaction_10478888": { "compartment": "compartment_12045", "id": "reaction_10478888", "reactome": "R-DME-5694442", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478884", "species_10478868" ], "products": [ "species_10478886" ], "modifiers": [], "additional_components": [ "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "FBgn0000339", "P49858", "FBgn0000339", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401" ] }, "reaction_10478866": { "compartment": "compartment_12045", "id": "reaction_10478866", "reactome": "R-DME-5694433", "name": "MIA2 binds PREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442366", "species_10478862" ], "products": [ "species_10478864" ], "modifiers": [], "additional_components": [ "FBgn0031779", "FBgn0286898", "Q9VMH4", "FBgn0031779", "Q9VMA7", "FBgn0286898" ] }, "reaction_10488161": { "compartment": "compartment_20699", "id": "reaction_10488161", "reactome": "R-DME-8849348", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488142", "species_10488157", "species_10488144" ], "products": [ "species_10488159" ], "modifiers": [], "additional_components": [ "O18334", "Rab6", "species_29438", "P16568", "FBgn0000183", "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438" ] }, "reaction_10488321": { "compartment": "compartment_12045", "id": "reaction_10488321", "reactome": "R-DME-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488317", "species_10488198" ], "products": [ "species_10488319" ], "modifiers": [], "additional_components": [ "Q9W4A0", "FBgn0015794", "species_29420", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29420" ] }, "reaction_10488324": { "compartment": "compartment_12045", "id": "reaction_10488324", "reactome": "R-DME-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488319", "species_29438" ], "products": [ "species_29420", "species_10488204" ], "modifiers": [ [ "species_10488319", "catalyst" ] ], "additional_components": [ "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29420", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29438", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29420" ] }, "reaction_10487912": { "compartment": "compartment_20699", "id": "reaction_10487912", "reactome": "R-DME-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10488138": { "compartment": "compartment_20699", "id": "reaction_10488138", "reactome": "R-DME-8849345", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_8848483" ], "products": [ "species_429785", "species_76194" ], "modifiers": [ [ "species_10488135", "catalyst" ] ], "additional_components": [ "D5AEK7", "FBgn0036623", "Q9VV49", "FBgn0036622" ] }, "reaction_10488172": { "compartment": "compartment_20699", "id": "reaction_10488172", "reactome": "R-DME-8849350", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488159", "species_10488168" ], "products": [ "species_10488170", "species_10488166" ], "modifiers": [], "additional_components": [ "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "Q7KNS3", "FBgn0015754", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420", "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29420", "FBgn0015754" ] }, "reaction_10488206": { "compartment": "compartment_12045", "id": "reaction_10488206", "reactome": "R-DME-8849353", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488170", "species_113592" ], "products": [ "species_10473488", "species_10488157", "species_29370", "species_10488186" ], "modifiers": [ [ "species_10488204", "catalyst" ], [ "species_8848483", "catalyst" ] ], "additional_components": [ "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29420", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "Q6WV17", "FBgn0031681", "Q6WV19", "FBgn0031530", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29438" ] }, "reaction_10486977": { "compartment": "compartment_20699", "id": "reaction_10486977", "reactome": "R-DME-6811418", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486962" ], "products": [ "species_10486350", "species_10486974", "species_10486421", "species_10486340" ], "modifiers": [ [ "species_10486962", "catalyst" ] ], "additional_components": [ "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "M9PGI6", "FBgn0260855", "P40945", "FBgn0013749", "species_29420", "M9PGI6", "FBgn0260855", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "O76767", "FBgn0267330", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "FBgn0264560", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "M9PGI6", "FBgn0260855" ] }, "reaction_10487089": { "compartment": "compartment_12045", "id": "reaction_10487089", "reactome": "R-DME-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487087" ], "products": [ "species_10487085", "species_10487003", "species_10487051", "species_10478404", "species_10486403" ], "modifiers": [], "additional_components": [ "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "Q8I0G5", "FBgn0028968", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9VYT6", "FBgn0030341", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "Q9VS46", "FBgn0035762", "Q9W4X9", "FBgn0004643", "O76767", "FBgn0267330", "O18405", "FBgn0019925", "O76767", "FBgn0267330", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "M9PGI6", "FBgn0260855", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "Q9VYT6", "FBgn0030341", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "species_29420", "O18332", "FBgn0285937", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496" ] }, "reaction_10486947": { "compartment": "compartment_20699", "id": "reaction_10486947", "reactome": "R-DME-6811412", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486943", "species_10486403" ], "products": [ "species_10486945" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560" ] }, "reaction_10486964": { "compartment": "compartment_20699", "id": "reaction_10486964", "reactome": "R-DME-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486954", "species_10486421", "species_10486708", "species_10486945", "species_10486960" ], "products": [ "species_10486962" ], "modifiers": [], "additional_components": [ "FBgn0260855", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "M9PGI6", "FBgn0260855" ] }, "reaction_10486950": { "compartment": "compartment_20699", "id": "reaction_10486950", "reactome": "R-DME-6811414", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10486939" ], "products": [ "species_10486943", "species_29420" ], "modifiers": [ [ "species_10486939", "catalyst" ] ], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "P40945", "FBgn0013749", "species_29420", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10486999": { "compartment": "compartment_12045", "id": "reaction_10486999", "reactome": "R-DME-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10486996" ], "products": [ "species_10478736", "species_29372", "species_10486987", "species_10478727", "species_10486982", "species_10478669", "species_10486992" ], "modifiers": [ [ "species_10486996", "catalyst" ] ], "additional_components": [ "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791", "Q23983", "FBgn0250791", "FBgn0039212", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "FBgn0037383", "FBgn0260855", "FBgn0035965", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10486952": { "compartment": "compartment_20699", "id": "reaction_10486952", "reactome": "R-DME-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486678", "species_10486340" ], "products": [ "species_10486937" ], "modifiers": [], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560" ] }, "reaction_10486941": { "compartment": "compartment_20699", "id": "reaction_10486941", "reactome": "R-DME-6811411", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486350", "species_10486937" ], "products": [ "species_10486939" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29420", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10487005": { "compartment": "compartment_12045", "id": "reaction_10487005", "reactome": "R-DME-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10487003", "species_10478727" ], "products": [ "species_10486996" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "M9PGI6", "FBgn0260855", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487007": { "compartment": "compartment_432051", "id": "reaction_10487007", "reactome": "R-DME-6811426", "name": "Retrograde COPI vesicles bind kinesin and microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486974", "species_10457347" ], "products": [ "species_10487001" ], "modifiers": [], "additional_components": [ "M9PGI6", "FBgn0260855", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "O76767", "FBgn0267330", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379", "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379", "M9PGI6", "FBgn0260855", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "O76767", "FBgn0267330", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341" ] }, "reaction_10487616": { "compartment": "compartment_263163", "id": "reaction_10487616", "reactome": "R-DME-6814684", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10487612", "species_10478727" ], "products": [ "species_10487614" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "Q9VR90", "FBgn0031106", "Q9W0N6", "FBgn0260862", "Q7JY00", "FBgn0037084", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9VR90", "FBgn0031106", "Q9W0N6", "FBgn0260862", "Q7JY00", "FBgn0037084", "Q23983", "FBgn0250791" ] }, "reaction_10487651": { "compartment": "compartment_263163", "id": "reaction_10487651", "reactome": "R-DME-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487644" ], "products": [ "species_10487648" ], "modifiers": [ [ "species_10487644", "catalyst" ] ], "additional_components": [ "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29438", "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29420", "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29438" ] }, "reaction_10487252": { "compartment": "compartment_263163", "id": "reaction_10487252", "reactome": "R-DME-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487206", "species_10487248" ], "products": [ "species_10487250" ], "modifiers": [], "additional_components": [ "P25160", "FBgn0000115", "species_29438", "Q9W389", "FBgn0030088", "Q9VHP1", "FBgn0037603", "Q9VGE4", "FBgn0037979", "Q9W1R3", "FBgn0034854", "Q9VGR1", "FBgn0037881", "Q7K4K7", "FBgn0086757", "Q9W3V2", "FBgn0029912", "Q9VGE4", "FBgn0037979", "Q9W1R3", "FBgn0034854", "Q9VGR1", "FBgn0037881", "Q7K4K7", "FBgn0086757", "Q9W3V2", "FBgn0029912", "P25160", "FBgn0000115", "species_29438", "Q9W389", "FBgn0030088", "Q9VHP1", "FBgn0037603" ] }, "reaction_10487270": { "compartment": "compartment_70101", "id": "reaction_10487270", "reactome": "R-DME-6814096", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487266", "species_10487200" ], "products": [ "species_10487268" ], "modifiers": [], "additional_components": [ "FBgn0039505", "species_29438", "P25160", "FBgn0000115", "species_29438", "P25160", "FBgn0000115", "Q9VB51", "FBgn0039505" ] }, "reaction_10487655": { "compartment": "compartment_263163", "id": "reaction_10487655", "reactome": "R-DME-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487642", "species_10487653" ], "products": [ "species_10487644" ], "modifiers": [], "additional_components": [ "O18339", "FBgn0015793", "species_29438", "FBgn0020620", "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29438" ] }, "reaction_10487208": { "compartment": "compartment_263163", "id": "reaction_10487208", "reactome": "R-DME-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487192", "species_10487200" ], "products": [ "species_10487206" ], "modifiers": [], "additional_components": [ "Q9W389", "FBgn0030088", "species_29438", "Q9VHP1", "FBgn0037603", "species_29438", "P25160", "FBgn0000115", "P25160", "FBgn0000115", "species_29438", "Q9W389", "FBgn0030088", "Q9VHP1", "FBgn0037603" ] }, "reaction_10487562": { "compartment": "compartment_263163", "id": "reaction_10487562", "reactome": "R-DME-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10478727", "species_10487552" ], "products": [ "species_10487560" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487261": { "compartment": "compartment_70101", "id": "reaction_10487261", "reactome": "R-DME-6814094", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487257", "species_10487200" ], "products": [ "species_10487259" ], "modifiers": [], "additional_components": [ "FBgn0037884", "species_29438", "P25160", "FBgn0000115", "species_29438", "P25160", "FBgn0000115", "Q9VGQ8", "FBgn0037884" ] }, "reaction_10487565": { "compartment": "compartment_263163", "id": "reaction_10487565", "reactome": "R-DME-6814678", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487560" ], "products": [ "species_10478736", "species_29370", "species_10478727", "species_10487508", "species_10487522", "species_10487506", "species_10487504" ], "modifiers": [ [ "species_10487560", "catalyst" ] ], "additional_components": [ "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791", "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "FBgn0260862", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "FBgn0031106", "FBgn0037084", "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487214": { "compartment": "compartment_263163", "id": "reaction_10487214", "reactome": "R-DME-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487182", "species_10487212" ], "products": [ "species_10487192" ], "modifiers": [], "additional_components": [ "FBgn0037603", "Q9W389", "FBgn0030088", "species_29438", "Q9W389", "FBgn0030088", "species_29438", "Q9VHP1", "FBgn0037603" ] }, "reaction_10447993": { "compartment": "compartment_70101", "id": "reaction_10447993", "reactome": "R-DME-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447892" ], "products": [ "species_10439074", "species_29372", "species_29420", "species_10447990", "species_10447884" ], "modifiers": [ [ "species_10447892", "catalyst" ] ], "additional_components": [ "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P27619", "FBgn0003392", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P27619", "FBgn0003392", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833" ] }, "reaction_10447894": { "compartment": "compartment_20699", "id": "reaction_10447894", "reactome": "R-DME-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439074", "species_10447876", "species_10447882", "species_10447884" ], "products": [ "species_29372", "species_10447892", "species_10444042" ], "modifiers": [], "additional_components": [ "FBgn0038659", "P61209", "FBgn0010348", "species_29438", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P27619", "FBgn0003392", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P61209", "FBgn0010348", "species_29420" ] }, "reaction_10449633": { "compartment": "compartment_70101", "id": "reaction_10449633", "reactome": "R-DME-434362", "name": "Recruitment Of Cytoplasmic Proteins To Vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447984", "species_10449619", "species_10449624", "species_10449610", "species_10449629" ], "products": [ "species_10447984", "species_10449631" ], "modifiers": [], "additional_components": [ "Q9VYH1", "FBgn0030449", "FBgn0003165", "FBgn0261279", "FBgn0010877", "Q9VE96", "FBgn0010877", "Q8IN05", "FBgn0261279", "P25822", "FBgn0003165", "Q9VYH1", "FBgn0030449" ] }, "reaction_10475663": { "compartment": "compartment_20699", "id": "reaction_10475663", "reactome": "R-DME-5671702", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439057", "species_10454937", "species_10475659" ], "products": [ "species_10475661" ], "modifiers": [], "additional_components": [ "FBgn0031450", "FBgn0039402", "FBgn0030089", "Q7KVR8", "FBgn0030089", "Q9VBI3", "FBgn0039402", "Q960X8", "FBgn0031450" ] }, "reaction_10449498": { "compartment": "compartment_70101", "id": "reaction_10449498", "reactome": "R-DME-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449493" ], "products": [ "species_10439074", "species_29372", "species_10449475", "species_29420", "species_10447884" ], "modifiers": [ [ "species_10449493", "catalyst" ] ], "additional_components": [ "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P27619", "FBgn0003392", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P27619", "FBgn0003392" ] }, "reaction_10449495": { "compartment": "compartment_70101", "id": "reaction_10449495", "reactome": "R-DME-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449489", "species_10439074", "species_10447882", "species_10447884" ], "products": [ "species_29372", "species_10449493", "species_10444042" ], "modifiers": [], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P27619", "FBgn0003392", "P61209", "FBgn0010348", "species_29420" ] }, "reaction_10471574": { "compartment": "compartment_263163", "id": "reaction_10471574", "reactome": "R-DME-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10471570" ], "products": [ "species_10471572" ], "modifiers": [], "additional_components": [ "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "B8A403", "FBgn0039132", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "P29742", "FBgn0000319", "species_1806289", "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "B8A403", "FBgn0039132", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "P29742", "FBgn0000319" ] }, "reaction_10444054": { "compartment": "compartment_70101", "id": "reaction_10444054", "reactome": "R-DME-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10444042" ], "products": [ "species_29420", "species_10444046" ], "modifiers": [ [ "species_10444051", "catalyst" ] ], "additional_components": [ "P61209", "FBgn0010348", "species_29420", "P61209", "FBgn0010348", "species_29438", "FBgn0264560" ] }, "reaction_10455085": { "compartment": "compartment_70101", "id": "reaction_10455085", "reactome": "R-DME-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454980", "species_10455081" ], "products": [ "species_10455014", "species_10455079" ], "modifiers": [], "additional_components": [ "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027" ] }, "reaction_10455083": { "compartment": "compartment_70101", "id": "reaction_10455083", "reactome": "R-DME-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455062", "species_10455079" ], "products": [ "species_10455060", "species_10455081" ], "modifiers": [], "additional_components": [ "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027", "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10455091": { "compartment": "compartment_876", "id": "reaction_10455091", "reactome": "R-DME-917730", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455089", "species_10455060" ], "products": [ "species_10455062", "species_10455087" ], "modifiers": [], "additional_components": [ "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450" ] }, "reaction_10465199": { "compartment": "compartment_984", "id": "reaction_10465199", "reactome": "R-DME-2168886", "name": "Hemopexin binds Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310", "species_10465195" ], "products": [ "species_10465197" ], "modifiers": [], "additional_components": [ "species_71185", "FBgn0035049", "Q9W122", "FBgn0035049", "species_71185" ] }, "reaction_10442798": { "compartment": "compartment_70101", "id": "reaction_10442798", "reactome": "R-DME-209859", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209911" ], "products": [ "species_113528", "species_209914" ], "modifiers": [ [ "species_10442795", "catalyst" ] ], "additional_components": [ "P05031", "FBgn0000422" ] }, "reaction_10442780": { "compartment": "compartment_70101", "id": "reaction_10442780", "reactome": "R-DME-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29500", "species_29368" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10442777", "catalyst" ] ], "additional_components": [ "Q9W0K2", "FBgn0035187", "species_111793" ] }, "reaction_10449260": { "compartment": "compartment_70101", "id": "reaction_10449260", "reactome": "R-DME-432148", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448753", "species_113592" ], "products": [ "species_29370", "species_10439430" ], "modifiers": [ [ "species_10449257", "catalyst" ] ], "additional_components": [ "FBgn0024846", "FBgn0024846", "FBgn0262733" ] }, "reaction_10447546": { "compartment": "compartment_70101", "id": "reaction_10447546", "reactome": "R-DME-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10447543", "catalyst" ] ], "additional_components": [ "Q9VJ79", "FBgn0085370", "Q9VFI9", "FBgn0038237", "B7YZV4", "FBgn0264815" ] }, "reaction_10447521": { "compartment": "compartment_70101", "id": "reaction_10447521", "reactome": "R-DME-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10447516", "catalyst" ] ], "additional_components": [ "FBgn0011676" ] }, "reaction_10448285": { "compartment": "compartment_876", "id": "reaction_10448285", "reactome": "R-DME-426223", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426219" ], "products": [ "species_426221" ], "modifiers": [ [ "species_10448280", "catalyst" ] ], "additional_components": [ "species_74113", "species_74016", "species_29926", "species_74016", "species_29926", "species_74113", "species_114519", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861" ] }, "reaction_10484607": { "compartment": "compartment_7660", "id": "reaction_10484607", "reactome": "R-DME-6799431", "name": "TP53 binds HIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467611", "species_10484603" ], "products": [ "species_10484605" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0035142", "Q9W0Q1", "FBgn0035142", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486113": { "compartment": "compartment_7660", "id": "reaction_10486113", "reactome": "R-DME-6805276", "name": "CDK5 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_113582", "species_10486103" ], "modifiers": [ [ "species_10486110", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P48609", "FBgn0013762", "Q9V3H5", "FBgn0027491" ] }, "reaction_10486083": { "compartment": "compartment_7660", "id": "reaction_10486083", "reactome": "R-DME-6805109", "name": "CDK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_113582", "species_10486081" ], "modifiers": [ [ "species_10427405", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P23573", "FBgn0004107" ] }, "reaction_10484601": { "compartment": "compartment_7660", "id": "reaction_10484601", "reactome": "R-DME-6799409", "name": "HIPK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467602" ], "products": [ "species_10467600", "species_113582", "species_10467592", "species_10481386" ], "modifiers": [ [ "species_10467602", "catalyst" ] ], "additional_components": [ "M9NFM7", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "M9NFM7", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379" ] }, "reaction_10486087": { "compartment": "compartment_7660", "id": "reaction_10486087", "reactome": "R-DME-6805122", "name": "AURKB binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470050", "species_10467755" ], "products": [ "species_10486085" ], "modifiers": [], "additional_components": [ "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227" ] }, "reaction_10486121": { "compartment": "compartment_7660", "id": "reaction_10486121", "reactome": "R-DME-6805399", "name": "TAF1 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_113582", "species_10486118" ], "modifiers": [ [ "species_10431420", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10467604": { "compartment": "compartment_7660", "id": "reaction_10467604", "reactome": "R-DME-3215251", "name": "TP53INP1 and HIPK2 bind TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467600", "species_10427813", "species_10467592" ], "products": [ "species_10467602" ], "modifiers": [], "additional_components": [ "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379", "Q8IMZ4", "FBgn0039044", "FBgn0035542", "M9NFM7", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379" ] }, "reaction_10481389": { "compartment": "compartment_7660", "id": "reaction_10481389", "reactome": "R-DME-6798374", "name": "DYRK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427813" ], "products": [ "species_113582", "species_10481386" ], "modifiers": [ [ "species_10481378", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0027101" ] }, "reaction_10467757": { "compartment": "compartment_7660", "id": "reaction_10467757", "reactome": "R-DME-3222128", "name": "NOC2L binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10467753" ], "products": [ "species_10467755" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0032925", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486098": { "compartment": "compartment_7660", "id": "reaction_10486098", "reactome": "R-DME-6805126", "name": "AURKB phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10486085" ], "products": [ "species_10486095", "species_113582" ], "modifiers": [ [ "species_10486085", "catalyst" ] ], "additional_components": [ "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227" ] }, "reaction_10486134": { "compartment": "compartment_7660", "id": "reaction_10486134", "reactome": "R-DME-6805470", "name": "AMPK phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_10427808", "species_113582" ], "modifiers": [ [ "species_10486131", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "O18645", "FBgn0023169", "A1Z7Q8", "FBgn0260972", "species_76577", "Q9VDD2", "FBgn0264357" ] }, "reaction_10486074": { "compartment": "compartment_7660", "id": "reaction_10486074", "reactome": "R-DME-6805059", "name": "CK2:FACT phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427813" ], "products": [ "species_113582", "species_10486053" ], "modifiers": [ [ "species_10486071", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278" ] }, "reaction_10486076": { "compartment": "compartment_7660", "id": "reaction_10486076", "reactome": "R-DME-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434698", "species_10486069" ], "products": [ "species_10486071" ], "modifiers": [], "additional_components": [ "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278" ] }, "reaction_10486142": { "compartment": "compartment_7660", "id": "reaction_10486142", "reactome": "R-DME-6805479", "name": "TP53RK phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_10427808", "species_113582" ], "modifiers": [ [ "species_10486139", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0035590" ] }, "reaction_10486000": { "compartment": "compartment_7660", "id": "reaction_10486000", "reactome": "R-DME-6804402", "name": "TP53 binds POU4F1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485996", "species_10427813" ], "products": [ "species_10485998" ], "modifiers": [], "additional_components": [ "FBgn0000028", "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P24350", "FBgn0000028" ] }, "reaction_10486006": { "compartment": "compartment_7660", "id": "reaction_10486006", "reactome": "R-DME-6804425", "name": "TP53 binds POU4F2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10486002" ], "products": [ "species_10486004" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0000028", "P24350", "FBgn0000028", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10467785": { "compartment": "compartment_7660", "id": "reaction_10467785", "reactome": "R-DME-3222259", "name": "PHF20 binds TP53 dimethylated on K370 and K382", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467781", "species_10467775" ], "products": [ "species_10467783" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0038016", "Q9VGA4", "FBgn0038016", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486215": { "compartment": "compartment_7660", "id": "reaction_10486215", "reactome": "R-DME-6805785", "name": "AKT phosphorylates PHF20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467775" ], "products": [ "species_113582", "species_10486213" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0038016", "FBgn0038016" ] }, "reaction_10484676": { "compartment": "compartment_7660", "id": "reaction_10484676", "reactome": "R-DME-6799777", "name": "TP53 family members bind PPP1R13B or TP53BP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481317", "species_10484670" ], "products": [ "species_10484674" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0034606", "Q86BG1", "FBgn0034606", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486219": { "compartment": "compartment_7660", "id": "reaction_10486219", "reactome": "R-DME-6805792", "name": "p-S291-PHF20 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486213" ], "products": [ "species_10486217" ], "modifiers": [], "additional_components": [ "FBgn0038016", "FBgn0038016" ] }, "reaction_10486046": { "compartment": "compartment_7660", "id": "reaction_10486046", "reactome": "R-DME-6804762", "name": "TP53 forms homotetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467282" ], "products": [ "species_10467611" ], "modifiers": [], "additional_components": [ "FBgn0039044", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10474397": { "compartment": "compartment_70101", "id": "reaction_10474397", "reactome": "R-DME-5632738", "name": "DDIT4 binds 14-3-3 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432018", "species_10474390" ], "products": [ "species_10474392" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "Q9VTH4", "FBgn0041094", "Q9VTI8", "FBgn0036165", "Q9VTH4", "FBgn0041094", "Q9VTI8", "FBgn0036165", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon" ] }, "reaction_10474394": { "compartment": "compartment_70101", "id": "reaction_10474394", "reactome": "R-DME-5632732", "name": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432018", "species_10440825" ], "products": [ "species_10474378" ], "modifiers": [ [ "species_10474392", "inhibitor" ] ], "additional_components": [ "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "FBgn0005198", "Q9VW83", "FBgn0005198", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "Q9VTH4", "FBgn0041094", "Q9VTI8", "FBgn0036165", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon" ] }, "reaction_10474353": { "compartment": "compartment_70101", "id": "reaction_10474353", "reactome": "R-DME-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474341", "species_10445887" ], "products": [ "species_10474351" ], "modifiers": [], "additional_components": [ "FBgn0034897", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9W1K5", "FBgn0034897" ] }, "reaction_10436944": { "compartment": "compartment_70101", "id": "reaction_10436944", "reactome": "R-DME-165179", "name": "Formation of TSC1:TSC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436938", "species_10436925" ], "products": [ "species_10436942" ], "modifiers": [], "additional_components": [ "FBgn0026317", "FBgn0005198", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317" ] }, "reaction_10474349": { "compartment": "compartment_70101", "id": "reaction_10474349", "reactome": "R-DME-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474341", "species_10474333" ], "products": [ "species_10474347" ], "modifiers": [], "additional_components": [ "FBgn0034897", "Q9V3P0", "FBgn0040309", "Q9V3P0", "FBgn0040309", "Q9W1K5", "FBgn0034897" ] }, "reaction_10474336": { "compartment": "compartment_70101", "id": "reaction_10474336", "reactome": "R-DME-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468393", "species_29408" ], "products": [ "species_29356", "species_10474333" ], "modifiers": [ [ "species_10468393", "catalyst" ] ], "additional_components": [ "Q9V3P0", "FBgn0040309", "Q9V3P0", "FBgn0040309", "Q9V3P0", "FBgn0040309" ] }, "reaction_10481119": { "compartment": "compartment_7660", "id": "reaction_10481119", "reactome": "R-DME-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434613", "species_10481115" ], "products": [ "species_10481117" ], "modifiers": [], "additional_components": [ "FBgn0025674", "FBgn0037093", "Q9VP22", "FBgn0037093", "Q961D1", "FBgn0025674" ] }, "reaction_10481276": { "compartment": "compartment_7660", "id": "reaction_10481276", "reactome": "R-DME-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481111", "species_10481256" ], "products": [ "species_10481258" ], "modifiers": [], "additional_components": [ "Q961D1", "FBgn0025674", "Q9VP22", "FBgn0037093", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9VP22", "FBgn0037093" ] }, "reaction_10481274": { "compartment": "compartment_7660", "id": "reaction_10481274", "reactome": "R-DME-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10481258" ], "products": [ "species_113582", "species_10481271" ], "modifiers": [ [ "species_10481258", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9VP22", "FBgn0037093", "Q961D1", "FBgn0025674", "Q9VP22", "FBgn0037093", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VW51", "FBgn0014037", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "P04052", "FBgn0003277", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9VP22", "FBgn0037093" ] }, "reaction_10481113": { "compartment": "compartment_7660", "id": "reaction_10481113", "reactome": "R-DME-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481109", "species_10434613" ], "products": [ "species_10481111" ], "modifiers": [], "additional_components": [ "FBgn0037093", "FBgn0025674", "Q961D1", "FBgn0025674", "Q9VP22", "FBgn0037093" ] }, "reaction_10485756": { "compartment": "compartment_70101", "id": "reaction_10485756", "reactome": "R-DME-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485748" ], "products": [ "species_10485754" ], "modifiers": [], "additional_components": [ "Q960C5", "FBgn0032633", "Q9W2D7", "FBgn0034655", "Q9W2D7", "FBgn0034655", "Q960C5", "FBgn0032633" ] }, "reaction_10485783": { "compartment": "compartment_70101", "id": "reaction_10485783", "reactome": "R-DME-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485772", "species_10485779" ], "products": [ "species_10485781" ], "modifiers": [], "additional_components": [ "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "FBgn0026378", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970" ] }, "reaction_10485774": { "compartment": "compartment_876", "id": "reaction_10485774", "reactome": "R-DME-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485770", "species_10485765" ], "products": [ "species_10485772" ], "modifiers": [], "additional_components": [ "FBgn0028970", "FBgn0037293", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970" ] }, "reaction_10485804": { "compartment": "compartment_17927", "id": "reaction_10485804", "reactome": "R-DME-6801242", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485788", "species_10485800" ], "products": [ "species_10485802" ], "modifiers": [], "additional_components": [ "FBgn0050109", "Q9V579", "FBgn0033413", "Q9V579", "FBgn0033413", "Q6NLJ9", "FBgn0050109" ] }, "reaction_10485807": { "compartment": "compartment_17906", "id": "reaction_10485807", "reactome": "R-DME-6801250", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590" ], "products": [ "species_1524101" ], "modifiers": [ [ "species_10485802", "catalyst" ] ], "additional_components": [ "Q9V579", "FBgn0033413", "Q6NLJ9", "FBgn0050109" ] }, "reaction_10430972": { "compartment": "compartment_70101", "id": "reaction_10430972", "reactome": "R-DME-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10430969", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_1562550", "Q9VLR3", "FBgn0032001" ] }, "reaction_10433723": { "compartment": "compartment_5460", "id": "reaction_10433723", "reactome": "R-DME-109759", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_500822" ], "products": [ "species_113581", "species_500823" ], "modifiers": [ [ "species_10433720", "catalyst" ] ], "additional_components": [ "CHEBI:17748", "CHEBI:16450", "CHEBI:15698", "species_109366", "species_109382", "CHEBI:15918", "FBgn0022338" ] }, "reaction_10431579": { "compartment": "compartment_70101", "id": "reaction_10431579", "reactome": "R-DME-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83962", "species_500244" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10431576", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "species_112016", "CHEBI:16450", "CHEBI:16704", "Q9VBA0", "FBgn0039464", "Q8T8S2", "FBgn0034800", "Q0E8U4", "FBgn0031489" ] }, "reaction_10433803": { "compartment": "compartment_70101", "id": "reaction_10433803", "reactome": "R-DME-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10433800", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_1524067", "species_418075", "Q9VC99", "FBgn0263398" ] }, "reaction_10430952": { "compartment": "compartment_70101", "id": "reaction_10430952", "reactome": "R-DME-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10430949", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_1524067", "species_418075", "Q9VC99", "FBgn0263398" ] }, "reaction_10479975": { "compartment": "compartment_70101", "id": "reaction_10479975", "reactome": "R-DME-6788295", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6788291" ], "products": [ "species_29372", "species_6788290" ], "modifiers": [ [ "species_10479972", "catalyst" ] ], "additional_components": [ "species_29926", "Q94529", "FBgn0019982" ] }, "reaction_10495070": { "compartment": "compartment_70101", "id": "reaction_10495070", "reactome": "R-DME-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10495067", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_1524067", "species_418075", "FBgn0022029" ] }, "reaction_10427902": { "compartment": "compartment_70101", "id": "reaction_10427902", "reactome": "R-DME-70361", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30170", "species_29410" ], "products": [ "species_29452", "species_29548" ], "modifiers": [ [ "species_10427899", "catalyst" ] ], "additional_components": [ "FBgn0263200" ] }, "reaction_10427912": { "compartment": "compartment_70101", "id": "reaction_10427912", "reactome": "R-DME-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10427909", "catalyst" ] ], "additional_components": [ "species_427523", "Q9W0P5", "FBgn0035147" ] }, "reaction_10427975": { "compartment": "compartment_70101", "id": "reaction_10427975", "reactome": "R-DME-70427", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10427861", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z7P1", "FBgn0033377", "A1Z9V3", "FBgn0033969" ] }, "reaction_10488852": { "compartment": "compartment_161320", "id": "reaction_10488852", "reactome": "R-DME-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10488849", "catalyst" ] ], "additional_components": [ "Q8IPB7", "FBgn0027611", "species_1562550" ] }, "reaction_10484649": { "compartment": "compartment_161320", "id": "reaction_10484649", "reactome": "R-DME-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10484646", "catalyst" ] ], "additional_components": [ "Q9VKV2", "FBgn0032253", "Q9VLI1", "FBgn0032067", "Q8IPB7", "FBgn0027611", "Q9VLI0", "FBgn0032068", "Q9VLH9", "FBgn0032069", "Q9VLI2", "FBgn0032066", "species_1562550" ] }, "reaction_10488857": { "compartment": "compartment_161320", "id": "reaction_10488857", "reactome": "R-DME-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10488854", "catalyst" ] ], "additional_components": [ "FBgn0037215" ] }, "reaction_10497920": { "compartment": "compartment_70101", "id": "reaction_10497920", "reactome": "R-DME-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10497917", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUY9", "FBgn0003076" ] }, "reaction_10428999": { "compartment": "compartment_70101", "id": "reaction_10428999", "reactome": "R-DME-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10428910" ], "products": [ "species_10428915", "species_29370" ], "modifiers": [ [ "species_10428996", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9XTL9", "FBgn0004507", "Q9XTL9", "FBgn0004507", "Q9VLS1", "FBgn0031995", "Q9W391", "FBgn0030087", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10451638": { "compartment": "compartment_70101", "id": "reaction_10451638", "reactome": "R-DME-453342", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428910", "species_76577" ], "products": [ "species_10451634" ], "modifiers": [ [ "species_30537", "inhibitor" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q9XTL9", "FBgn0004507", "species_76577", "Q9XTL9", "FBgn0004507" ] }, "reaction_10428063": { "compartment": "compartment_70101", "id": "reaction_10428063", "reactome": "R-DME-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10428060", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "species_29926", "A0A0U1RVK6", "FBgn0032820" ] }, "reaction_10468121": { "compartment": "compartment_17957", "id": "reaction_10468121", "reactome": "R-DME-3262512", "name": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10468118", "catalyst" ] ], "additional_components": [ "FBgn0031463" ] }, "reaction_10444376": { "compartment": "compartment_5460", "id": "reaction_10444376", "reactome": "R-DME-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_113525", "species_29376" ], "modifiers": [ [ "species_10444373", "catalyst" ] ], "additional_components": [ "FBgn0003067" ] }, "reaction_10444312": { "compartment": "compartment_70101", "id": "reaction_10444312", "reactome": "R-DME-372449", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_372364" ], "products": [ "species_29654", "species_29492" ], "modifiers": [ [ "species_10432422", "catalyst" ] ], "additional_components": [ "FBgn0037912" ] }, "reaction_10440823": { "compartment": "compartment_70101", "id": "reaction_10440823", "reactome": "R-DME-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10440820", "catalyst" ] ], "additional_components": [ "Q9VKX2", "FBgn0262782" ] }, "reaction_10427830": { "compartment": "compartment_70101", "id": "reaction_10427830", "reactome": "R-DME-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_29420", "species_113528", "species_29492" ], "modifiers": [ [ "species_10427827", "catalyst" ] ], "additional_components": [ "P20007", "FBgn0003067", "Q7JXB5", "FBgn0034356" ] }, "reaction_10428116": { "compartment": "compartment_5460", "id": "reaction_10428116", "reactome": "R-DME-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113557", "species_29376" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10428113", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "Q0E9E2", "FBgn0027580", "species_266099", "species_199238" ] }, "reaction_10468116": { "compartment": "compartment_70101", "id": "reaction_10468116", "reactome": "R-DME-3257122", "name": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10468111", "catalyst" ] ], "additional_components": [ "FBgn0034611" ] }, "reaction_10440813": { "compartment": "compartment_70101", "id": "reaction_10440813", "reactome": "R-DME-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10440810", "catalyst" ] ], "additional_components": [ "Q9VAJ9", "FBgn0039674" ] }, "reaction_10445386": { "compartment": "compartment_70101", "id": "reaction_10445386", "reactome": "R-DME-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10440810", "catalyst" ] ], "additional_components": [ "Q9VAJ9", "FBgn0039674" ] }, "reaction_10468169": { "compartment": "compartment_17957", "id": "reaction_10468169", "reactome": "R-DME-3266566", "name": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10468166", "catalyst" ] ], "additional_components": [ "FBgn0031463" ] }, "reaction_10428264": { "compartment": "compartment_5460", "id": "reaction_10428264", "reactome": "R-DME-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_113552" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10428224", "catalyst" ] ], "additional_components": [ "Q8IPY3", "FBgn0001125" ] }, "reaction_10429153": { "compartment": "compartment_17957", "id": "reaction_10429153", "reactome": "R-DME-71825", "name": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10429150", "catalyst" ] ], "additional_components": [ "FBgn0031463" ] }, "reaction_10474612": { "compartment": "compartment_70101", "id": "reaction_10474612", "reactome": "R-DME-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10440630", "catalyst" ] ], "additional_components": [ "FBgn0086254" ] }, "reaction_10474624": { "compartment": "compartment_70101", "id": "reaction_10474624", "reactome": "R-DME-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5652213", "species_29360" ], "products": [ "species_29532", "species_70106", "species_73473" ], "modifiers": [ [ "species_10474621", "catalyst" ] ], "additional_components": [ "species_1562550", "O96299", "FBgn0022359" ] }, "reaction_10427884": { "compartment": "compartment_70101", "id": "reaction_10427884", "reactome": "R-DME-70333", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29532", "species_113592" ], "products": [ "species_29370", "species_31221" ], "modifiers": [ [ "species_10427881", "catalyst" ], [ "species_29804", "catalyst" ], [ "species_29370", "inhibitor" ] ], "additional_components": [ "Q9VW84", "FBgn0036942" ] }, "reaction_10484615": { "compartment": "compartment_70101", "id": "reaction_10484615", "reactome": "R-DME-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799497", "species_113592" ], "products": [ "species_70106", "species_29370", "species_6799493" ], "modifiers": [ [ "species_10484612", "catalyst" ] ], "additional_components": [ "FBgn0031428" ] }, "reaction_10427894": { "compartment": "compartment_70101", "id": "reaction_10427894", "reactome": "R-DME-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_30393", "species_75970" ], "modifiers": [ [ "species_10427891", "catalyst" ] ], "additional_components": [ "P07764", "FBgn0000064" ] }, "reaction_10440638": { "compartment": "compartment_70101", "id": "reaction_10440638", "reactome": "R-DME-196372", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193124", "species_29360" ], "products": [ "species_196366", "species_70106", "species_73473" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10440398": { "compartment": "compartment_70101", "id": "reaction_10440398", "reactome": "R-DME-193961", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196366" ], "products": [ "species_193092" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10459245": { "compartment": "compartment_984", "id": "reaction_10459245", "reactome": "R-DME-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1449707", "species_10459241" ], "products": [ "species_10459243" ], "modifiers": [], "additional_components": [ "CHEBI:27584", "species_193055", "species_193977", "CHEBI:16973", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "CHEBI:27584", "species_193055", "species_193977", "CHEBI:16973" ] }, "reaction_10440406": { "compartment": "compartment_17957", "id": "reaction_10440406", "reactome": "R-DME-194023", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193977", "species_29366" ], "products": [ "species_70106", "species_29364", "species_194035" ], "modifiers": [ [ "species_10440403", "catalyst" ] ], "additional_components": [ "FBgn0000056" ] }, "reaction_10489504": { "compartment": "compartment_70101", "id": "reaction_10489504", "reactome": "R-DME-8862137", "name": "HSD17B2 oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10489501", "catalyst" ] ], "additional_components": [ "FBgn0000056" ] }, "reaction_10479237": { "compartment": "compartment_5460", "id": "reaction_10479237", "reactome": "R-DME-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_5696835" ], "products": [ "species_113529", "species_5696848", "species_113600" ], "modifiers": [ [ "species_10479234", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10478098": { "compartment": "compartment_70101", "id": "reaction_10478098", "reactome": "R-DME-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10478095", "catalyst" ] ], "additional_components": [ "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043" ] }, "reaction_10440273": { "compartment": "compartment_70101", "id": "reaction_10440273", "reactome": "R-DME-193143", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_193057" ], "products": [ "species_193132", "species_29356", "species_29366", "species_29460" ], "modifiers": [ [ "species_10440256", "catalyst" ] ], "additional_components": [ "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395" ] }, "reaction_10496005": { "compartment": "compartment_7660", "id": "reaction_10496005", "reactome": "R-DME-9009282", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491664" ], "products": [ "species_113582", "species_10495911" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q24040", "FBgn0013753", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10492400": { "compartment": "compartment_7660", "id": "reaction_10492400", "reactome": "R-DME-8938356", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492396", "species_10491656" ], "products": [ "species_10492398" ], "modifiers": [], "additional_components": [ "FBgn0011640", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q94901", "FBgn0011640" ] }, "reaction_10491660": { "compartment": "compartment_7660", "id": "reaction_10491660", "reactome": "R-DME-8877902", "name": "Activated AR binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491656", "species_10473354" ], "products": [ "species_10491658" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10491668": { "compartment": "compartment_7660", "id": "reaction_10491668", "reactome": "R-DME-8877941", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491662", "species_10491664" ], "products": [ "species_10491666" ], "modifiers": [], "additional_components": [ "P42003", "FBgn0011648", "O62609", "FBgn0011655", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "P42003", "FBgn0011648", "O62609", "FBgn0011655" ] }, "reaction_10495959": { "compartment": "compartment_7660", "id": "reaction_10495959", "reactome": "R-DME-9008822", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10495951" ], "products": [ "species_113541", "species_10491664" ], "modifiers": [ [ "species_10495956", "catalyst" ] ], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "FBgn0022768" ] }, "reaction_10495914": { "compartment": "compartment_7660", "id": "reaction_10495914", "reactome": "R-DME-9008412", "name": "CDK4 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491664" ], "products": [ "species_113582", "species_10495911" ], "modifiers": [ [ "species_10493280", "catalyst" ] ], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q24040", "FBgn0013753", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10495757": { "compartment": "compartment_7660", "id": "reaction_10495757", "reactome": "R-DME-8985343", "name": "RUNX2 binds SOX9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474272", "species_10491656" ], "products": [ "species_10495755" ], "modifiers": [], "additional_components": [ "FBgn0024288", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VA17", "FBgn0024288" ] }, "reaction_10449051": { "compartment": "compartment_70101", "id": "reaction_10449051", "reactome": "R-DME-430021", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10449036" ], "products": [ "species_10449024", "species_76577" ], "modifiers": [ [ "species_10449048", "catalyst" ] ], "additional_components": [ "P21187", "FBgn0265297", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P21187", "FBgn0265297", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q95RR8", "FBgn0035397", "A1Z7K9", "FBgn0033352" ] }, "reaction_10493178": { "compartment": "compartment_70101", "id": "reaction_10493178", "reactome": "R-DME-8941312", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449024", "species_6782337" ], "products": [ "species_10493168" ], "modifiers": [ [ "species_10493173", "catalyst" ] ], "additional_components": [ "P21187", "FBgn0265297", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P21187", "FBgn0265297", "species_6782337", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0035889" ] }, "reaction_10488832": { "compartment": "compartment_70101", "id": "reaction_10488832", "reactome": "R-DME-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1221562" ], "products": [ "species_1221562", "species_10430300" ], "modifiers": [ [ "species_10488829", "catalyst" ] ], "additional_components": [ "P35122", "FBgn0010288", "Q9VYQ8", "FBgn0030366", "P55824", "FBgn0005632" ] }, "reaction_10488784": { "compartment": "compartment_7660", "id": "reaction_10488784", "reactome": "R-DME-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488611" ], "products": [ "species_164121", "species_10488710" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11" ] }, "reaction_10488771": { "compartment": "compartment_7660", "id": "reaction_10488771", "reactome": "R-DME-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488732", "species_10488712" ], "products": [ "species_10488611", "species_10488769" ], "modifiers": [], "additional_components": [ "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q9I7T6", "FBgn0035455", "Q9VQ00", "FBgn0031331", "Q9VYN3", "FBgn0030386", "Q7K738", "FBgn0026316", "Q9VUR4", "FBgn0036516", "Q9Y165", "FBgn0027609", "P25867", "eff", "A1Z8B5", "FBgn0033544", "P25153", "FBgn0004436", "Q9VX25", "FBgn0030863", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P25153", "FBgn0004436", "Q9VTY6", "FBgn0264848", "Q9I7T6", "FBgn0035455", "Q9VQ00", "FBgn0031331", "Q9VYN3", "FBgn0030386", "P52485", "FBgn0015320", "Q7K738", "FBgn0026316", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9VX25", "FBgn0030863", "A1Z8B5", "FBgn0033544", "Q9VUR4", "FBgn0036516" ] }, "reaction_10488836": { "compartment": "compartment_70101", "id": "reaction_10488836", "reactome": "R-DME-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488834" ], "products": [ "species_1221561", "species_10430729" ], "modifiers": [ [ "species_10488829", "catalyst" ] ], "additional_components": [ "P35122", "FBgn0010288", "Q9VYQ8", "FBgn0030366", "P55824", "FBgn0005632" ] }, "reaction_10488708": { "compartment": "compartment_70101", "id": "reaction_10488708", "reactome": "R-DME-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488649", "species_10488615" ], "products": [ "species_10488651", "species_10488706" ], "modifiers": [], "additional_components": [ "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "Q9VYN3", "FBgn0030386", "Q9VQ00", "FBgn0031331", "Q9I7T6", "FBgn0035455", "P52485", "FBgn0015320", "Q7JW03", "FBgn0029996", "Q7K738", "FBgn0026316", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q29R09", "FBgn0023528", "Q9VX25", "FBgn0030863", "Q9VXE8", "FBgn0267384", "P52486", "FBgn0015321", "Q8SYG3", "FBgn0058045", "Q9VUR4", "FBgn0036516", "Q9VTY6", "FBgn0264848", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "Q7JW03", "FBgn0029996", "Q9VTY6", "FBgn0264848", "P52486", "FBgn0015321", "Q7K738", "FBgn0026316", "Q9VQ00", "FBgn0031331", "Q9VYN3", "FBgn0030386", "P52485", "FBgn0015320", "Q9I7T6", "FBgn0035455", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q29R09", "FBgn0023528", "Q8SYG3", "FBgn0058045", "Q9VXE8", "FBgn0267384", "Q9VUR4", "FBgn0036516", "Q9VX25", "FBgn0030863", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10488613": { "compartment": "compartment_7660", "id": "reaction_10488613", "reactome": "R-DME-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427430", "species_10488565" ], "products": [ "species_113541", "species_10488611" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0023143", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488773": { "compartment": "compartment_7660", "id": "reaction_10488773", "reactome": "R-DME-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427430", "species_10488710" ], "products": [ "species_10488712", "species_113541" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488776": { "compartment": "compartment_70101", "id": "reaction_10488776", "reactome": "R-DME-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488617", "species_113592", "species_10426987" ], "products": [ "species_111294", "species_10488649" ], "modifiers": [ [ "species_10488617", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8T0L3", "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488841": { "compartment": "compartment_70101", "id": "reaction_10488841", "reactome": "R-DME-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488838" ], "products": [ "species_10426977", "species_10426979", "species_10426981", "species_10426983", "species_10426985", "species_10426969", "species_10426971", "species_10426973", "species_10426975" ], "modifiers": [ [ "species_10477601", "catalyst" ] ], "additional_components": [ "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0035402" ] }, "reaction_10488779": { "compartment": "compartment_70101", "id": "reaction_10488779", "reactome": "R-DME-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488651" ], "products": [ "species_10488617", "species_76577" ], "modifiers": [ [ "species_10488651", "catalyst" ] ], "additional_components": [ "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8T0L3", "FBgn0023143", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488845": { "compartment": "compartment_70101", "id": "reaction_10488845", "reactome": "R-DME-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488843" ], "products": [ "species_1221567", "species_1221557", "species_1221559" ], "modifiers": [ [ "species_10477601", "catalyst" ] ], "additional_components": [ "FBgn0035402" ] }, "reaction_10488782": { "compartment": "compartment_70101", "id": "reaction_10488782", "reactome": "R-DME-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457011", "species_113592", "species_10426987" ], "products": [ "species_111294", "species_10488651" ], "modifiers": [ [ "species_10457011", "catalyst" ] ], "additional_components": [ "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "FBgn0023143" ] }, "reaction_10495281": { "compartment": "compartment_7660", "id": "reaction_10495281", "reactome": "R-DME-8956659", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10458548" ], "products": [ "species_113582", "species_10495278" ], "modifiers": [ [ "species_10476652", "catalyst" ] ], "additional_components": [] }, "reaction_10495297": { "compartment": "compartment_70101", "id": "reaction_10495297", "reactome": "R-DME-8956684", "name": "ITCH polyubiquitinates TP73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495289", "species_10426987" ], "products": [ "species_10495294" ], "modifiers": [ [ "species_10456470", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8IMZ4", "FBgn0039044", "FBgn0003557" ] }, "reaction_10495299": { "compartment": "compartment_13231", "id": "reaction_10495299", "reactome": "R-DME-8957241", "name": "TP73 tetramer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495289" ], "products": [ "species_10481315" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10495269": { "compartment": "compartment_7660", "id": "reaction_10495269", "reactome": "R-DME-8956568", "name": "RUNX1 binds the core TAL1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489794", "species_10495265" ], "products": [ "species_10495267" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "P11420", "FBgn0267821", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "M9PI02", "FBgn0265598", "Q9W4X2", "FBgn0011276", "Q7KVG9", "FBgn0013764", "P11420", "FBgn0267821", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "M9PI02", "FBgn0265598", "Q9W4X2", "FBgn0011276", "Q7KVG9", "FBgn0013764", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10495285": { "compartment": "compartment_7660", "id": "reaction_10495285", "reactome": "R-DME-8956676", "name": "YAP1 binds TP73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495278", "species_10481315" ], "products": [ "species_10495283" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "Q45VV3", "yki" ] }, "reaction_10495301": { "compartment": "compartment_70101", "id": "reaction_10495301", "reactome": "R-DME-8957265", "name": "26S proteasome degrades TP73 polyubiquitinated by ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495294" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10489814": { "compartment": "compartment_7660", "id": "reaction_10489814", "reactome": "R-DME-8865482", "name": "KMT2A (MLL) binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489794", "species_10489810" ], "products": [ "species_10489812" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0003862", "P20659", "FBgn0003862", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10495274": { "compartment": "compartment_7660", "id": "reaction_10495274", "reactome": "R-DME-8956639", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10489794" ], "products": [ "species_10495272" ], "modifiers": [ [ "species_10476652", "inhibitor" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q45VV3", "yki" ] }, "reaction_10438764": { "compartment": "compartment_7660", "id": "reaction_10438764", "reactome": "R-DME-176973", "name": "Association of MCM8 with ORC:origin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426917", "species_10426938" ], "products": [ "species_10426942" ], "modifiers": [], "additional_components": [ "Q24168", "FBgn0015270", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "FBgn0003227", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181" ] }, "reaction_10427248": { "compartment": "compartment_7660", "id": "reaction_10427248", "reactome": "R-DME-68849", "name": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427210", "species_10427244" ], "products": [ "species_10427246" ], "modifiers": [], "additional_components": [ "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918" ] }, "reaction_10482653": { "compartment": "compartment_6799713", "id": "reaction_10482653", "reactome": "R-DME-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10482575" ], "products": [ "species_10482651" ], "modifiers": [], "additional_components": [ "O96692", "FBgn0283666", "Q9VMJ6", "FBgn0031760", "Q6NP91", "FBgn0033259", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "Q8IQC6", "FBgn0052039", "Q9VH76", "FBgn0266720", "P36975", "FBgn0011288", "Q86BK8", "FBgn0015791", "Q9VHG4", "FBgn0037671", "P45437", "FBgn0008635", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "P49283", "FBgn0011672", "P08646", "RAS85D", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "Q7KK97", "FBgn0028563", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q9VLT5", "FBgn0011230", "Q9VJW9", "FBgn0259984", "Q7YTY6", "FBgn0028988", "Q6QU65", "FBgn0265140", "X2JE21", "FBgn0259110", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9VS89", "FBgn0035798", "Q9VZA4", "FBgn0260657", "Q9NBC8", "FBgn0039595", "P12080", "FBgn0001250", "P23380", "FBgn0262736", "P09478", "FBgn0000036", "Q9VGD4", "FBgn0037989", "Q9W4F7", "FBgn0029737", "B7YZT5", "FBgn0286511", "M9PHI0", "FBgn0263220", "Q9VWE0", "dome", "Q9VWE0", "dome", "Q9W4F7", "FBgn0029737", "B7YZT5", "FBgn0286511", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9VMJ6", "FBgn0031760", "Q9VGD4", "FBgn0037989", "Q6NP91", "FBgn0033259", "P49283", "FBgn0011672", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "O96692", "FBgn0283666", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q86BK8", "FBgn0015791", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VLT5", "FBgn0011230", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9NBC8", "FBgn0039595", "Q9VZA4", "FBgn0260657", "Q7KK97", "FBgn0028563", "P23380", "FBgn0262736", "P09478", "FBgn0000036", "Q8IQC6", "FBgn0052039", "M9PHI0", "FBgn0263220", "Q9VJW9", "FBgn0259984", "Q7YTY6", "FBgn0028988", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "P08646", "RAS85D", "P45437", "FBgn0008635", "Q9VHG4", "FBgn0037671", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140", "P12080", "FBgn0001250" ] }, "reaction_10483433": { "compartment": "compartment_1462052", "id": "reaction_10483433", "reactome": "R-DME-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10483133" ], "products": [ "species_10483431" ], "modifiers": [], "additional_components": [ "Q9V3V6", "Rpt5", "Q9VDL0", "FBgn0038808", "P08736", "FBgn0284245", "P05303", "FBgn0000557", "Q9VHP0", "FBgn0263231", "Q7KN62", "FBgn0286784", "P13060", "FBgn0000559", "Q7JY94", "FBgn0034366", "B7Z0E0", "FBgn0001248", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710", "Q7JYW9", "FBgn0001187", "Q9W330", "FBgn0001186", "Q9VCZ5", "FBgn0038978", "Q24537", "Dsp1", "Q05783", "FBgn0004362", "E1JIT5", "FBgn0038979", "M9PE19", "FBgn0035348", "Q9W1K6", "FBgn0034898", "Q9VUJ1", "Prosbeta2", "O61443", "FBgn0024846", "P40301", "Prosalpha2", "Q95083", "Prosalpha5", "Q9VY39", "FBgn0030562", "Q8T3W8", "FBgn0037879", "Q9VT82", "FBgn0036070", "Q9VY19", "FBgn0020508", "Q9W2H4", "FBgn0034623", "Q8IRL3", "FBgn0052679", "Q9VI17", "FBgn0260766", "Q9VY18", "FBgn0015010", "Q9W2H3", "FBgn0034624", "Q8IND6", "FBgn0051296", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10483596" ], "products": [ "species_10483636" ], "modifiers": [], "additional_components": [ "O46037", "FBgn0004397", "Q94527", "Rel", "Q9W4K2", "FBgn0029708", "X2JAR4", "FBgn0261848", "Q7JQR3", "FBgn0033814", "Q8MM24", "FBgn0020416", "Q8MLZ7", "FBgn0020414", "Q23997", "FBgn0013763", "Q9W303", "FBgn0026415", "Q9VZV2", "FBgn0035398", "Q9V3D4", "FBgn0020415", "Q8T0R7", "FBgn0064237", "Q9VGN8", "FBgn0037900", "O76901", "FBgn0025382", "Q7KUC2", "FBgn0085484", "P29349", "FBgn0000382", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VE79", "FBgn0038611", "Q7K485", "FBgn0029093", "Q9VWZ7", "FBgn0030887", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q9VHE4", "FBgn0037687", "Q9VH14", "FBgn0025879", "Q7KRY7", "FBgn0263289", "Q9W122", "FBgn0035049", "Q9VJQ0", "FBgn0028888", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "A1Z9N6", "FBgn0261269", "Q9W0M1", "FBgn0035168", "P18824", "arm", "Q9VZI1", "FBgn0035499", "Q9VB21", "FBgn0039527", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "P13395", "FBgn0250789", "Q9VG73", "FBgn0038046", "O76895", "FBgn0023535", "O18388", "FBgn0262743", "Q9V9J3", "phospho-Src42A", "Q8IQM9", "FBgn0263607", "Q95TL8", "FBgn0030734", "Q86PD7", "FBgn0036999", "Q9VF87", "FBgn0038320", "Q7JQR3", "FBgn0033814", "Q95TL8", "FBgn0030734", "Q94527", "Rel", "Q9VH14", "FBgn0025879", "Q9VF87", "FBgn0038320", "Q23997", "FBgn0013763", "Q9W303", "FBgn0026415", "Q9VZV2", "FBgn0035398", "Q9V3D4", "FBgn0020415", "Q8T0R7", "FBgn0064237", "Q8MM24", "FBgn0020416", "Q8MLZ7", "FBgn0020414", "Q7KUC2", "FBgn0085484", "Q9VJQ0", "FBgn0028888", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "A1Z9N6", "FBgn0261269", "Q7K485", "FBgn0029093", "Q9W122", "FBgn0035049", "Q9VG73", "FBgn0038046", "Q8IQM9", "FBgn0263607", "X2JAR4", "FBgn0261848", "Q9VZI1", "FBgn0035499", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "P13395", "FBgn0250789", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "O46037", "FBgn0004397", "Q9VWZ7", "FBgn0030887", "Q9VE79", "FBgn0038611", "Q9VHE4", "FBgn0037687", "Q9W4K2", "FBgn0029708", "Q9V9J3", "phospho-Src42A", "O76895", "FBgn0023535", "P29349", "FBgn0000382", "Q9VB21", "FBgn0039527", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "P18824", "arm", "Q9W0M1", "FBgn0035168", "O76901", "FBgn0025382", "Q9VGN8", "FBgn0037900", "Q7KRY7", "FBgn0263289", "Q86PD7", "FBgn0036999", "O18388", "FBgn0262743" ] }, "reaction_10484598": { "compartment": "compartment_6799351", "id": "reaction_10484598", "reactome": "R-DME-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484554" ], "products": [ "species_10484596" ], "modifiers": [], "additional_components": [ "Q9W179", "FBgn0035001", "Q9VIG0", "FBgn0032916", "Q9VYJ4", "FBgn0030421", "O62531", "FBgn0024833", "Q9VXM4", "FBgn0030703", "B7YZF8", "FBgn0259221", "P09478", "FBgn0000036", "Q9VGD4", "FBgn0037989", "M9PHI0", "FBgn0263220", "P12080", "FBgn0001250", "Q9VWE0", "dome", "Q9VXG0", "FBgn0030752", "O96692", "FBgn0283666", "Q94515", "FBgn0001941", "Q9VW73", "FBgn0036932", "B7YZT5", "FBgn0286511", "Q9VMJ6", "FBgn0031760", "Q9VAP3", "FBgn0039637", "Q6NP91", "FBgn0033259", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999", "Q9VH76", "FBgn0266720", "P36975", "FBgn0011288", "Q8IRI6", "FBgn0264574", "E1JI63", "FBgn0035815", "Q9NBC8", "FBgn0039595", "A1Z7G7", "FBgn0033313", "Q9VA10", "FBgn0039821", "Q8SZ78", "FBgn0039818", "Q9VGJ9", "FBgn0037933", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "Q9VXD1", "FBgn0261245", "Q9W4B6", "FBgn0029771", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9VLT5", "FBgn0011230", "P35992", "FBgn0004370", "Q960U8", "FBgn0004797", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "Q9VJW9", "FBgn0259984", "Q8MPP3", "FBgn0033438", "P08645", "FBgn0004636", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140", "Q9VZA4", "FBgn0260657", "Q9VXV6", "FBgn0040285", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9V7D2", "FBgn0022097", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "Q7KK97", "FBgn0028563", "Q9W4F7", "FBgn0029737", "Q9V8I2", "FBgn0034350", "Q9VJD2", "FBgn0032642", "Q9VSZ1", "FBgn0035995", "Q8SY02", "FBgn0051634", "Q03751", "FBgn0004179", "Q9VP04", "FBgn0037110", "M9PBR6", "FBgn0053523", "A1Z7G7", "FBgn0033313", "Q9VA10", "FBgn0039821", "Q8SZ78", "FBgn0039818", "Q9VGJ9", "FBgn0037933", "M9PBR6", "FBgn0053523", "E1JI63", "FBgn0035815", "Q9VIG0", "FBgn0032916", "Q8IRI6", "FBgn0264574", "Q9VXM4", "FBgn0030703", "Q9W179", "FBgn0035001", "Q9V7D2", "FBgn0022097", "Q9VXV6", "FBgn0040285", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "P12080", "FBgn0001250", "Q8SY02", "FBgn0051634", "Q9VSZ1", "FBgn0035995", "P09478", "FBgn0000036", "Q9W4B6", "FBgn0029771", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "Q9VXD1", "FBgn0261245", "Q9VYJ4", "FBgn0030421", "Q9NBC8", "FBgn0039595", "O62531", "FBgn0024833", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "Q94515", "FBgn0001941", "Q9VLT5", "FBgn0011230", "Q960U8", "FBgn0004797", "P35992", "FBgn0004370", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q9VGD4", "FBgn0037989", "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "B7YZT5", "FBgn0286511", "Q03751", "FBgn0004179", "Q9VP04", "FBgn0037110", "B7YZF8", "FBgn0259221", "Q9VJW9", "FBgn0259984", "M9PHI0", "FBgn0263220", "Q9VXG0", "FBgn0030752", "Q9VW73", "FBgn0036932", "Q7KK97", "FBgn0028563", "Q9VZA4", "FBgn0260657", "Q8MPP3", "FBgn0033438", "Q9VAP3", "FBgn0039637", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9V8I2", "FBgn0034350", "Q9VJD2", "FBgn0032642", "O96692", "FBgn0283666", "Q6NP91", "FBgn0033259", "Q9VMJ6", "FBgn0031760", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9W4F7", "FBgn0029737", "Q9VWE0", "dome", "P08645", "FBgn0004636", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140" ] }, "reaction_10481684": { "compartment": "compartment_6798757", "id": "reaction_10481684", "reactome": "R-DME-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481590" ], "products": [ "species_10481682" ], "modifiers": [], "additional_components": [ "Q9VXG0", "FBgn0030752", "Q9VIM0", "FBgn0032864", "Q9VXD1", "FBgn0261245", "Q9W4B6", "FBgn0029771", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "P23380", "FBgn0262736", "Q9VSZ1", "FBgn0035995", "O02194", "FBgn0284421", "Q8SY02", "FBgn0051634", "Q9W1I8", "FBgn0034913", "Q9VC27", "FBgn0039234", "Q9VQM2", "FBgn0031505", "Q7JYV2", "FBgn0033876", "Q8SY19", "FBgn0025814", "Q8SY53", "FBgn0032015", "A1Z959", "FBgn0050486", "Q9VHJ0", "FBgn0037650", "Q8IRK1", "FBgn0264297", "Q9W129", "FBgn0035042", "A8WHB7", "FBgn0054049", "Q9VIN6", "FBgn0032853", "O18405", "FBgn0019925", "Q9VLH1", "FBgn0032074", "Q9V3I2", "FBgn0014010", "Q9V9S0", "FBgn0032949", "P25228", "FBgn0005586", "Q9VZP9", "FBgn0035444", "Q9VD68", "FBgn0038912", "Q9VW01", "FBgn0036877", "Q8I0P9", "FBgn0000032", "Q9VW00", "FBgn0036876", "B7Z080", "FBgn0036875", "Q9VQ86", "FBgn0031397", "Q9VMY5", "FBgn0037215", "Q7KN92", "FBgn0027538", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "P08645", "FBgn0004636", "Q9VHV5", "FBgn0037551", "Q0KHU5", "FBgn0052699", "B7YZF8", "FBgn0259221", "Q24319", "FBgn0014868", "Q9VZA4", "FBgn0260657", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q03751", "FBgn0004179", "A1Z7S0", "FBgn0015477", "Q9VW73", "FBgn0036932", "Q9Y125", "FBgn0000416", "Q03751", "FBgn0004179", "Q9VQM2", "FBgn0031505", "Q8SY19", "FBgn0025814", "A1Z959", "FBgn0050486", "Q9W129", "FBgn0035042", "Q9VIN6", "FBgn0032853", "Q9VHJ0", "FBgn0037650", "Q8IRK1", "FBgn0264297", "A8WHB7", "FBgn0054049", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "A1Z7S0", "FBgn0015477", "Q24319", "FBgn0014868", "Q9VZA4", "FBgn0260657", "Q9W4B6", "FBgn0029771", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "Q9VXD1", "FBgn0261245", "Q9VW73", "FBgn0036932", "Q9VLH1", "FBgn0032074", "Q9VHV5", "FBgn0037551", "Q9VXG0", "FBgn0030752", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "O02194", "FBgn0284421", "P23380", "FBgn0262736", "Q9VMY5", "FBgn0037215", "Q9VSZ1", "FBgn0035995", "Q0KHU5", "FBgn0052699", "Q7JYV2", "FBgn0033876", "Q9V9S0", "FBgn0032949", "Q9W1I8", "FBgn0034913", "Q9VZP9", "FBgn0035444", "Q8SY02", "FBgn0051634", "O18405", "FBgn0019925", "Q9V3I2", "FBgn0014010", "P25228", "FBgn0005586", "Q9VC27", "FBgn0039234", "Q9Y125", "FBgn0000416", "Q9VIM0", "FBgn0032864", "B7YZF8", "FBgn0259221", "Q8SY53", "FBgn0032015", "Q9VW01", "FBgn0036877", "Q9VW00", "FBgn0036876", "Q9VQ86", "FBgn0031397", "Q9VD68", "FBgn0038912", "Q8I0P9", "FBgn0000032", "B7Z080", "FBgn0036875", "P08645", "FBgn0004636", "Q7KN92", "FBgn0027538" ] }, "reaction_10484242": { "compartment": "compartment_1470028", "id": "reaction_10484242", "reactome": "R-DME-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484040" ], "products": [ "species_10484240" ], "modifiers": [], "additional_components": [ "A1Z8C9", "FBgn0050016", "Q9VQX4", "FBgn0031589", "Q7KN62", "FBgn0286784", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630", "Q9W3C4", "FBgn0041629", "Q8IQM9", "FBgn0263607", "Q7JYA0", "FBgn0033873", "Q9VWE8", "FBgn0031050", "Q9VRP2", "FBgn0035630", "Q9V420", "FBgn0004465", "Q9VEK7", "FBgn0025456", "P83099", "FBgn0259680", "A1ZBX7", "FBgn0034539", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9VQI7", "FBgn0031479", "Q9VS41", 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homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10482267" ], "products": [ "species_10482367" ], "modifiers": [], "additional_components": [ "Q9VH14", "FBgn0025879", "P13395", "FBgn0250789", "Q9VTP0", "FBgn0259140", "Q9VHE4", "FBgn0037687", "Q9VZI1", "FBgn0035499", "Q9V3D4", "FBgn0020415", "Q8T0R7", "FBgn0064237", "Q8MM24", "FBgn0020416", "Q8MLZ7", "FBgn0020414", "Q23997", "FBgn0013763", "Q9W303", "FBgn0026415", "Q9VZV2", "FBgn0035398", "Q9VJ39", "FBgn0032721", "Q9VWZ7", "FBgn0030887", "Q9VUY9", "FBgn0003076", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9VYH1", "FBgn0030449", "X2JAR4", "FBgn0261848", "Q9VU84", "FBgn0036372", "Q9VLR3", "FBgn0032001", "P29349", "FBgn0000382", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q8IQM9", "FBgn0263607", "Q9VGN8", "FBgn0037900", "Q9VG73", "FBgn0038046", "Q7JQR3", "FBgn0033814", "Q9VNK6", "FBgn0037396", "Q9W4K2", "FBgn0029708", "Q7K485", "FBgn0029093", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "Q9VJQ0", "FBgn0028888", "A1Z9N6", "FBgn0261269", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "Q9XZF0", "FBgn0026749", "Q9W122", "FBgn0035049", "Q86PD7", "FBgn0036999", "B7Z0E0", "FBgn0001248", "Q9VF87", "FBgn0038320", "B7Z0E0", "FBgn0001248", "Q7JQR3", "FBgn0033814", "Q9VF87", "FBgn0038320", "Q9VH14", "FBgn0025879", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q9VYH1", "FBgn0030449", "Q9VU84", "FBgn0036372", "Q9VNK6", "FBgn0037396", "Q9VLR3", "FBgn0032001", "Q9VJQ0", "FBgn0028888", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "A1Z9N6", "FBgn0261269", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9W122", "FBgn0035049", "Q7K485", "FBgn0029093", "Q9VG73", "FBgn0038046", "Q8IQM9", "FBgn0263607", "X2JAR4", "FBgn0261848", "Q9VZI1", "FBgn0035499", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VTP0", "FBgn0259140", "Q9VUY9", "FBgn0003076", "Q9VJ39", "FBgn0032721", "P13395", "FBgn0250789", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "Q9VWZ7", "FBgn0030887", "Q9VHE4", "FBgn0037687", "Q9W4K2", "FBgn0029708", "Q9XZF0", "FBgn0026749", "P29349", "FBgn0000382", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "Q9VGN8", "FBgn0037900", "Q86PD7", "FBgn0036999", "Q8T0R7", "FBgn0064237", "Q9W303", "FBgn0026415", "Q8MM24", "FBgn0020416", "Q9VZV2", "FBgn0035398", "Q8MLZ7", "FBgn0020414", "Q9V3D4", "FBgn0020415", "Q23997", "FBgn0013763" ] }, "reaction_10485728": { "compartment": "compartment_984", "id": "reaction_10485728", "reactome": "R-DME-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485116" ], "products": [ "species_10485198" ], "modifiers": [], "additional_components": [ "Q9VIM0", "FBgn0032864", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "P23380", "FBgn0262736", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "P49283", "FBgn0011672", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P55162", "FBgn0011771", "Q9VHM2", "FBgn0037622", "Q9VLT5", "FBgn0011230", "Q9VLL4", 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"FBgn0259110", "Q6QU65", "FBgn0265140" ] }, "reaction_10482080": { "compartment": "compartment_876", "id": "reaction_10482080", "reactome": "R-DME-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481912" ], "products": [ "species_10482078" ], "modifiers": [], "additional_components": [ "O18334", "Rab6", "Q7KK97", "FBgn0028563", "Q9XZ10", "FBgn0028671", "Q8IQC6", "FBgn0052039", "Q9VEX6", "FBgn0287225", "Q9V3I2", "FBgn0014010", "Q7KY04", "FBgn0016701", "P91926", "FBgn0264855", "Q7KN92", "FBgn0027538", "A1Z7S0", "FBgn0015477", "P25228", "FBgn0005586", "Q9VP04", "FBgn0037110", "Q9W4A0", "FBgn0015794", "P45437", "FBgn0008635", "O15971", "FBgn0015789", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "P40792", "RAC1_DROME", "Q9VIW6", "FBgn0032782", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VPH1", "FBgn0036978", "Q9VPU6", "FBgn0031289", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "P55162", "FBgn0011771", "Q7KRW4", "FBgn0039640", "Q9VLL4", "FBgn0032042", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "P48608", "FBgn0011202", "Q9VZ20", "FBgn0030276", "Q9W5Y0", "FBgn0031081", "P12080", "FBgn0001250", "P48148", "Rho1", "Q09101", "FBgn0010114", "Q9VYR4", "FBgn0001083", "O76742", "FBgn0015795", "Q9W5Y0", "FBgn0031081", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q7KRW4", "FBgn0039640", "P48148", "Rho1", "P25228", "FBgn0005586", "O76742", "FBgn0015795", "O18334", "Rab6", "P91926", "FBgn0264855", "A1Z7S0", "FBgn0015477", "Q9V3I2", "FBgn0014010", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q7KY04", "FBgn0016701", "Q7KK97", "FBgn0028563", "Q9W4A0", "FBgn0015794", "O15971", "FBgn0015789", "Q9VIW6", "FBgn0032782", "Q9VPH1", "FBgn0036978", "Q9VPU6", "FBgn0031289", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q8IQC6", "FBgn0052039", "P55162", "FBgn0011771", "Q9VLL4", "FBgn0032042", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "P48608", "FBgn0011202", "Q9VZ20", "FBgn0030276", "Q9XZ10", "FBgn0028671", "Q9VEX6", "FBgn0287225", "Q9VP04", "FBgn0037110", "P12080", "FBgn0001250", "P45437", "FBgn0008635", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "P40792", "RAC1_DROME", "Q7KN92", "FBgn0027538" ] }, "reaction_10493472": { "compartment": "compartment_70101", "id": "reaction_10493472", "reactome": "R-DME-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493467", "species_113592" ], "products": [ "species_10493470", "species_29370" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10493490": { "compartment": "compartment_70101", "id": "reaction_10493490", "reactome": "R-DME-8948143", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493470", "species_113592" ], "products": [ "species_10493487", "species_29370" ], "modifiers": [ [ "species_10440003", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "FBgn0262733" ] }, "reaction_10493476": { "compartment": "compartment_17906", "id": "reaction_10493476", "reactome": "R-DME-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475486" ], "products": [ "species_10493474" ], "modifiers": [], "additional_components": [ "FBgn0260945", "FBgn0260945" ] }, "reaction_10493496": { "compartment": "compartment_17906", "id": "reaction_10493496", "reactome": "R-DME-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493467", "species_113592" ], "products": [ "species_29370", "species_10493493" ], "modifiers": [ [ "species_10493474", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "FBgn0260945" ] }, "reaction_10493484": { "compartment": "compartment_70101", "id": "reaction_10493484", "reactome": "R-DME-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493470" ], "products": [ "species_10493467" ], "modifiers": [ [ "species_10493481", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "FBgn0023517" ] }, "reaction_10470847": { "compartment": "compartment_17906", "id": "reaction_10470847", "reactome": "R-DME-5205682", "name": "Parkin promotes the ubiquitination of mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457377", "species_10457379", "species_10470842", "species_10426987", "species_10470844" ], "products": [ "species_10470752", "species_10470784", "species_10470758", "species_10470745" ], "modifiers": [ [ "species_10470798", "catalyst" ] ], "additional_components": [ "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "FBgn0029870", "Q9VKP4", "FBgn0260453", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q94920", "FBgn0004363", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0037008", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "FBgn0037008", "FBgn0029870", "Q0KHV6", "FBgn0029891", "Q7KTX7", "FBgn0041100" ] }, "reaction_10470828": { "compartment": "compartment_70101", "id": "reaction_10470828", "reactome": "R-DME-5205673", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470784", "species_10470752", "species_10470789", "species_10470758", "species_10470745" ], "products": [ "species_10470791" ], "modifiers": [], "additional_components": [ "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "FBgn0003231", "FBgn0037008", "FBgn0029870", "Q7YU24", "FBgn0029870", "Q9VPD5", "FBgn0037008", "P14199", "FBgn0003231", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354" ] }, "reaction_10470826": { "compartment": "compartment_17906", "id": "reaction_10470826", "reactome": "R-DME-5205672", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470804" ], "products": [ "species_10470796" ], "modifiers": [], "additional_components": [ "FBgn0029891", "FBgn0029891" ] }, "reaction_10470824": { "compartment": "compartment_21994", "id": "reaction_10470824", "reactome": "R-DME-5205663", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470816", "species_10470820" ], "products": [ "species_10470822" ], "modifiers": [], "additional_components": [ "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "Q7YU24", "FBgn0029870", "Q9VPD5", "FBgn0037008", "P14199", "FBgn0003231", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q7YU24", "FBgn0029870", "Q9VPD5", "FBgn0037008", "P14199", "FBgn0003231", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255" ] }, "reaction_10470832": { "compartment": "compartment_17927", "id": "reaction_10470832", "reactome": "R-DME-5205681", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470804" ], "products": [ "species_10470830" ], "modifiers": [], "additional_components": [ "FBgn0029891", "FBgn0029891" ] }, "reaction_10470800": { "compartment": "compartment_17906", "id": "reaction_10470800", "reactome": "R-DME-5205652", "name": "Pink1 recruits Parkin to the outer mitochondrial membrane.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456711", "species_10470796" ], "products": [ "species_10470798" ], "modifiers": [], "additional_components": [ "FBgn0041100", "FBgn0029891", "Q0KHV6", "FBgn0029891", "Q7KTX7", "FBgn0041100" ] }, "reaction_10498066": { "compartment": "compartment_70101", "id": "reaction_10498066", "reactome": "R-DME-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498064" ], "products": [ "species_10498062", "species_10498041" ], "modifiers": [], "additional_components": [ "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10498039": { "compartment": "compartment_70101", "id": "reaction_10498039", "reactome": "R-DME-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498013", "species_10498035" ], "products": [ "species_10498037" ], "modifiers": [], "additional_components": [ "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10498122": { "compartment": "compartment_70101", "id": "reaction_10498122", "reactome": "R-DME-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498118", "species_10473486" ], "products": [ "species_10498120" ], "modifiers": [], "additional_components": [ "M9PJN5", "FBgn0026428", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "M9PJN5", "FBgn0026428", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802" ] }, "reaction_10498091": { "compartment": "compartment_70101", "id": "reaction_10498091", "reactome": "R-DME-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498037" ], "products": [ "species_10498089" ], "modifiers": [], "additional_components": [ "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q400N2", "FBgn0086690", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q9VA37", "FBgn0039802", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10498093": { "compartment": "compartment_70101", "id": "reaction_10498093", "reactome": "R-DME-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498089" ], "products": [ "species_10498064" ], "modifiers": [], "additional_components": [ "Q400N2", "FBgn0086690", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q9VA37", "FBgn0039802", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802" ] }, "reaction_10498015": { "compartment": "compartment_70101", "id": "reaction_10498015", "reactome": "R-DME-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498011", "species_10456711" ], "products": [ "species_10498013" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "FBgn0041100", "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10476379": { "compartment": "compartment_70101", "id": "reaction_10476379", "reactome": "R-DME-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476267" ], "products": [ "species_10476252", "species_10476207" ], "modifiers": [], "additional_components": [ "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539" ] }, "reaction_10476250": { "compartment": "compartment_70101", "id": "reaction_10476250", "reactome": "R-DME-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460755" ], "products": [ "species_10476237" ], "modifiers": [], "additional_components": [ "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325" ] }, "reaction_10476377": { "compartment": "compartment_70101", "id": "reaction_10476377", "reactome": "R-DME-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476211", "species_10476263" ], "products": [ "species_10476265" ], "modifiers": [], "additional_components": [ "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813" ] }, "reaction_10476248": { "compartment": "compartment_70101", "id": "reaction_10476248", "reactome": "R-DME-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476225", "species_10476227" ], "products": [ "species_10476229" ], "modifiers": [], "additional_components": [ "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "B7Z0R7", "FBgn0039705", "species_1806289", "M9PER1", "FBgn0035850", "species_1806289", "M9PER1", "FBgn0035850", "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "B7Z0R7", "FBgn0039705" ] }, "reaction_10476246": { "compartment": "compartment_70101", "id": "reaction_10476246", "reactome": "R-DME-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476100" ], "products": [ "species_10460794" ], "modifiers": [], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960", "Q7KTS2", "FBgn0037363", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10476244": { "compartment": "compartment_70101", "id": "reaction_10476244", "reactome": "R-DME-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10476241", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "A1ZAS8", "FBgn0027506" ] }, "reaction_10475727": { "compartment": "compartment_70101", "id": "reaction_10475727", "reactome": "R-DME-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040", "species_10475494" ], "products": [ "species_10475696" ], "modifiers": [], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10476239": { "compartment": "compartment_70101", "id": "reaction_10476239", "reactome": "R-DME-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10476237" ], "products": [ "species_10475715", "species_29370" ], "modifiers": [ [ "species_10460794", "catalyst" ] ], "additional_components": [ "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475724": { "compartment": "compartment_17938", "id": "reaction_10475724", "reactome": "R-DME-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040" ], "products": [ "species_10445903" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10475722", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198" ] }, "reaction_10476299": { "compartment": "compartment_70101", "id": "reaction_10476299", "reactome": "R-DME-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476199", "species_10476252" ], "products": [ "species_10476263" ], "modifiers": [], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366" ] }, "reaction_10476297": { "compartment": "compartment_70101", "id": "reaction_10476297", "reactome": "R-DME-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476278" ], "products": [ "species_10476199" ], "modifiers": [ [ "species_10476294", "catalyst" ] ], "additional_components": [ "Q9VEG5", "FBgn0038539", "Q9W2S2", "FBgn0052672", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q9VPW2", "FBgn0031298" ] }, "reaction_10476232": { "compartment": "compartment_70101", "id": "reaction_10476232", "reactome": "R-DME-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5681998", "species_10476207" ], "products": [ "species_10476209", "species_10476211" ], "modifiers": [ [ "species_10476229", "catalyst" ] ], "additional_components": [ "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "species_1602375", "FBgn0036813", "species_1806289", "M9PER1", "FBgn0035850", "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "B7Z0R7", "FBgn0039705" ] }, "reaction_10476103": { "compartment": "compartment_70101", "id": "reaction_10476103", "reactome": "R-DME-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475691" ], "products": [ "species_10476100", "species_29370" ], "modifiers": [ [ "species_10475691", "catalyst" ] ], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960", "Q7KTS2", "FBgn0037363", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475718": { "compartment": "compartment_12045", "id": "reaction_10475718", "reactome": "R-DME-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_5676030" ], "modifiers": [ [ "species_10475715", "catalyst" ] ], "additional_components": [ "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325" ] }, "reaction_10460797": { "compartment": "compartment_70101", "id": "reaction_10460797", "reactome": "R-DME-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460757", "species_113592" ], "products": [ "species_29370", "species_10460763" ], "modifiers": [ [ "species_10460794", "catalyst" ] ], "additional_components": [ "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475708": { "compartment": "compartment_70101", "id": "reaction_10475708", "reactome": "R-DME-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475494", "species_10445887" ], "products": [ "species_10475496" ], "modifiers": [], "additional_components": [ "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10476091": { "compartment": "compartment_74700", "id": "reaction_10476091", "reactome": "R-DME-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475946" ], "products": [ "species_10475701", "species_10437109" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691" ] }, "reaction_10476347": { "compartment": "compartment_5683628", "id": "reaction_10476347", "reactome": "R-DME-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476209" ], "products": [ "species_10476338" ], "modifiers": [ [ "species_10476345", "catalyst" ], [ "species_10454980", "catalyst" ] ], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "species_1602375", "species_1602375", "Q9VEG5", "FBgn0038539", "Q9W2S2", "FBgn0052672", "Q9W1M7", "FBgn0015277", "Q9VK07", "FBgn0032499", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10475706": { "compartment": "compartment_17938", "id": "reaction_10475706", "reactome": "R-DME-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475696", "species_113592" ], "products": [ "species_29370", "species_10475703" ], "modifiers": [ [ "species_10475696", "catalyst" ] ], "additional_components": [ "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10476407": { "compartment": "compartment_70101", "id": "reaction_10476407", "reactome": "R-DME-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475701" ], "products": [ "species_29372", "species_10475494" ], "modifiers": [], "additional_components": [ "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475505": { "compartment": "compartment_70101", "id": "reaction_10475505", "reactome": "R-DME-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475496" ], "products": [ "species_29370", "species_10475502" ], "modifiers": [ [ "species_10475496", "catalyst" ] ], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475694": { "compartment": "compartment_70101", "id": "reaction_10475694", "reactome": "R-DME-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475502" ], "products": [ "species_29370", "species_10475691" ], "modifiers": [ [ "species_10475502", "catalyst" ] ], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10476270": { "compartment": "compartment_70101", "id": "reaction_10476270", "reactome": "R-DME-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476265" ], "products": [ "species_10476267" ], "modifiers": [ [ "species_10476265", "catalyst" ] ], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813", "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813" ] }, "reaction_10475948": { "compartment": "compartment_70101", "id": "reaction_10475948", "reactome": "R-DME-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475703" ], "products": [ "species_29370", "species_10475946" ], "modifiers": [ [ "species_10445887", "catalyst" ] ], "additional_components": [ "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10496854": { "compartment": "compartment_70101", "id": "reaction_10496854", "reactome": "R-DME-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476254" ], "products": [ "species_10476375" ], "modifiers": [], "additional_components": [ "Q7JY94", "FBgn0034366", "Q9VTU1", "FBgn0036255", "Q9VTU1", "FBgn0036255", "Q7JY94", "FBgn0034366" ] }, "reaction_10476328": { "compartment": "compartment_12045", "id": "reaction_10476328", "reactome": "R-DME-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475715" ], "products": [ "species_10476326" ], "modifiers": [], "additional_components": [ "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325" ] }, "reaction_10476322": { "compartment": "compartment_70101", "id": "reaction_10476322", "reactome": "R-DME-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476209" ], "products": [ "species_5681998", "species_10476199" ], "modifiers": [ [ "species_10476294", "catalyst" ] ], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "species_1602375", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q9VPW2", "FBgn0031298" ] }, "reaction_10476128": { "compartment": "compartment_70101", "id": "reaction_10476128", "reactome": "R-DME-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693050", "species_10476124" ], "products": [ "species_10476126" ], "modifiers": [], "additional_components": [ "M9PER1", "FBgn0035850", "Q9VIE1", "FBgn0032935", "M9PER1", "FBgn0035850", "Q9VIE1", "FBgn0032935", "species_1806198" ] }, "reaction_10476256": { "compartment": "compartment_70101", "id": "reaction_10476256", "reactome": "R-DME-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476218", "species_10476252" ], "products": [ "species_10476254" ], "modifiers": [], "additional_components": [ "FBgn0036255", "Q7JY94", "FBgn0034366", "Q7JY94", "FBgn0034366", "Q9VTU1", "FBgn0036255" ] }, "reaction_350436": { "compartment": "compartment_70101", "id": "reaction_350436", "reactome": "R-DME-350436", "name": "DGO binds to DSH", "reversible": "false", "notes": "Diego (DGO) binding to Dishevelled (DSH) enhances Frizzled (FZ) PCP signalling. DGO, like FZ is required in R3/Distal cell fate. DGO binds to PDZ domain of DSH. DGO binding to DSH protects it from (Prickle) PK binding and its antagonistic effects. DGO could help promote DSH activation via stimulation of its phosphorylation.", "reactants": [ "species_450795", "species_351073" ], "products": [ "species_450734" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK" ] }, "reaction_350486": { "compartment": "compartment_70101", "id": "reaction_350486", "reactome": "R-DME-350486", "name": "DSH binds to FZ at the plasma membrane", "reversible": "false", "notes": "In the cytosol, the PDZ domain of Dishevelled (DSH) binds to the transmembrane receptor Frizzled (FZ) at the plasma membrane.", "reactants": [ "species_450698", "species_205749" ], "products": [ "species_450779" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "Q9V5N8", "STAN", "P18537", "FZ", "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ" ] }, "reaction_350408": { "compartment": "compartment_70101", "id": "reaction_350408", "reactome": "R-DME-350408", "name": "PK binds to VANG at the plasma membrane", "reversible": "false", "notes": "C-terminal region of Vang Gogh (VANG) binds to a C-terminal region of Prickle (PK). Both VANG and PK are both able to bind to themselves in the same regions.", "reactants": [ "species_351050", "species_450779" ], "products": [ "species_450795" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK" ] }, "reaction_10493702": { "compartment": "compartment_7660", "id": "reaction_10493702", "reactome": "R-DME-8951676", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464533", "species_10489801" ], "products": [ "species_10493700" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd", "FBgn0083981", "M9PI08", "FBgn0083981", "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_390133": { "compartment": "compartment_13231", "id": "reaction_390133", "reactome": "R-DME-390133", "name": "YKI transports from the cytosol to the nucleus", "reversible": "false", "notes": "The transcription factor Yorkie (YKI) translocates from the cytosol to the nucleus.", "reactants": [ "species_390114" ], "products": [ "species_390143" ], "modifiers": [], "additional_components": [] }, "reaction_390184": { "compartment": "compartment_7660", "id": "reaction_390184", "reactome": "R-DME-390184", "name": "YKI binds to SD and activates transcription", "reversible": "false", "notes": "The transcriptional factor Yorkie (YKI) forms a transcriptional activation complex for its target genes with Scalloped (SD).", "reactants": [ "species_390187", "species_390143" ], "products": [ "species_390092" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_451819": { "compartment": "compartment_7660", "id": "reaction_451819", "reactome": "R-DME-451819", "name": "YKI binds to HTH and TSH and activates transcription", "reversible": "false", "notes": "Yorkie (YKI) binds to the DNA-binding transcription factor, Homothorax (HTH). HTH in conjunction with the DNA-binding transcription factor, Teashirt (TSH) regulate the YKI target gene for the microRNA bantam (ban). HTH and YKI are both bound to the same region of the bantam locus in eye discs. This suggests that YKI, HTH, and TSH form a DNA-binding complex which activates transcription for the bantam target gene.", "reactants": [ "species_451881", "species_451832", "species_390143" ], "products": [ "species_451887" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P22265", "TSH", "O46339", "HTH" ] }, "reaction_10436586": { "compartment": "compartment_5460", "id": "reaction_10436586", "reactome": "R-DME-163320", "name": "Association of mTERF with the termination sequence", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164569", "species_10436582" ], "products": [ "species_10436584" ], "modifiers": [], "additional_components": [ "FBgn0028530", "Q9V3F3", "FBgn0028530" ] }, "reaction_10432638": { "compartment": "compartment_7660", "id": "reaction_10432638", "reactome": "R-DME-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10432467" ], "products": [ "species_113550", "species_113582", "species_10432459" ], "modifiers": [ [ "species_10431174", "catalyst" ] ], "additional_components": [ "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10432479": { "compartment": "compartment_7660", "id": "reaction_10432479", "reactome": "R-DME-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432427", "species_30595" ], "products": [ "species_10431322", "species_113541", "species_10432477" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10432430": { "compartment": "compartment_7660", "id": "reaction_10432430", "reactome": "R-DME-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431434", "species_30595" ], "products": [ "species_113541", "species_10432427" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10432494": { "compartment": "compartment_7660", "id": "reaction_10432494", "reactome": "R-DME-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10432477" ], "products": [ "species_10431317", "species_10431432", "species_113541", "species_10431420", "species_10432492" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10434104": { "compartment": "compartment_7660", "id": "reaction_10434104", "reactome": "R-DME-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433060", "species_30595" ], "products": [ "species_10433097", "species_113541" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10497528": { "compartment": "compartment_7660", "id": "reaction_10497528", "reactome": "R-DME-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10432427" ], "products": [ "species_164121", "species_113541", "species_10432427" ], "modifiers": [ [ "species_10431174", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10433062": { "compartment": "compartment_7660", "id": "reaction_10433062", "reactome": "R-DME-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10432492" ], "products": [ "species_10433060", "species_113541" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10497530": { "compartment": "compartment_7660", "id": "reaction_10497530", "reactome": "R-DME-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431434", "species_30595" ], "products": [ "species_10431434", "species_113541" ], "modifiers": [ [ "species_10431174", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10434782": { "compartment": "compartment_7660", "id": "reaction_10434782", "reactome": "R-DME-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10434765" ], "products": [ "species_10431174", "species_10434780" ], "modifiers": [], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P20232", "FBgn0010422", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q7JRJ1", "FBgn0033166", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "A8JV07", "FBgn0030738", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434796": { "compartment": "compartment_7660", "id": "reaction_10434796", "reactome": "R-DME-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434792" ], "products": [ "species_10434794" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434818": { "compartment": "compartment_7660", "id": "reaction_10434818", "reactome": "R-DME-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10434780" ], "products": [ "species_10434792", "species_30595" ], "modifiers": [], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "species_110577", "species_113592", "species_29494", "species_29438" ] }, "reaction_10492379": { "compartment": "compartment_161320", "id": "reaction_10492379", "reactome": "R-DME-8938108", "name": "SERPINB13 binds cathepsin L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492375", "species_10492373" ], "products": [ "species_10492377" ], "modifiers": [], "additional_components": [ "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229" ] }, "reaction_10492383": { "compartment": "compartment_161320", "id": "reaction_10492383", "reactome": "R-DME-8938121", "name": "SERPINB13 binds CTSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492373", "species_10465003" ], "products": [ "species_10492381" ], "modifiers": [], "additional_components": [ "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293" ] }, "reaction_10492387": { "compartment": "compartment_7660", "id": "reaction_10492387", "reactome": "R-DME-8938217", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467716", "species_10489794" ], "products": [ "species_10492385" ], "modifiers": [], "additional_components": [ "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715" ] }, "reaction_10491720": { "compartment": "compartment_7660", "id": "reaction_10491720", "reactome": "R-DME-8878050", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491687" ], "products": [ "species_113582", "species_10491717" ], "modifiers": [ [ "species_10469635", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617", "FBgn0035142" ] }, "reaction_10491722": { "compartment": "compartment_7660", "id": "reaction_10491722", "reactome": "R-DME-8878054", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10489794" ], "products": [ "species_113582", "species_10491715" ], "modifiers": [ [ "species_10469635", "catalyst" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0035142" ] }, "reaction_10492299": { "compartment": "compartment_7660", "id": "reaction_10492299", "reactome": "R-DME-8937989", "name": "RUNX1 binds PRC1 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492295", "species_10489794" ], "products": [ "species_10492297" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10491724": { "compartment": "compartment_7660", "id": "reaction_10491724", "reactome": "R-DME-8878056", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489794", "species_10458126" ], "products": [ "species_10491687" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0261617", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10492446": { "compartment": "compartment_7660", "id": "reaction_10492446", "reactome": "R-DME-8938913", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492442", "species_10489794" ], "products": [ "species_10492444" ], "modifiers": [], "additional_components": [ "FBgn0000567", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "P11536", "FBgn0000567" ] }, "reaction_10492480": { "compartment": "compartment_7660", "id": "reaction_10492480", "reactome": "R-DME-8938951", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492476", "species_10489794" ], "products": [ "species_10492478" ], "modifiers": [], "additional_components": [ "O16117", "FBgn0005561", "O18381", "FBgn0005558", "P23758", "FBgn0003130", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "O16117", "FBgn0005561", "O18381", "FBgn0005558", "P23758", "FBgn0003130" ] }, "reaction_10492459": { "compartment": "compartment_7660", "id": "reaction_10492459", "reactome": "R-DME-8938930", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492455", "species_10489794" ], "products": [ "species_10492457" ], "modifiers": [], "additional_components": [ "P11536", "FBgn0000567", "Q01842", "FBgn0000097", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "P11536", "FBgn0000567", "Q01842", "FBgn0000097" ] }, "reaction_10494980": { "compartment": "compartment_7660", "id": "reaction_10494980", "reactome": "R-DME-8953115", "name": "E2F6:TFDP1 binds to MGA:MAX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494970", "species_10494976" ], "products": [ "species_10494978" ], "modifiers": [], "additional_components": [ "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763" ] }, "reaction_10495062": { "compartment": "compartment_7660", "id": "reaction_10495062", "reactome": "R-DME-8954082", "name": "E2F6 binds the PRC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495049", "species_10495058" ], "products": [ "species_10495060" ], "modifiers": [], "additional_components": [ "Q9W215", "FBgn0034763", "Q9VB08", "FBgn0003330", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "Q9VKL0", "FBgn0032330", "P39769", "FBgn0004861", "Q9W523", "FBgn0004860", "Q9W215", "FBgn0034763", "Q9VB08", "FBgn0003330", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "Q9VKL0", "FBgn0032330", "P39769", "FBgn0004861", "Q9W523", "FBgn0004860" ] }, "reaction_10495047": { "compartment": "compartment_7660", "id": "reaction_10495047", "reactome": "R-DME-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494968", "species_10457961" ], "products": [ "species_10495045" ], "modifiers": [], "additional_components": [ "FBgn0011763", "Q24318", "FBgn0011763", "Q27368", "phospho-E2f1" ] }, "reaction_10494984": { "compartment": "compartment_7660", "id": "reaction_10494984", "reactome": "R-DME-8953418", "name": "EHMT1:EHMT2 complex binds E2F6.com-1 core", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468978", "species_10494978" ], "products": [ "species_10494982" ], "modifiers": [], "additional_components": [ "M9PGH7", "FBgn0040372", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "M9PGH7", "FBgn0040372" ] }, "reaction_10495850": { "compartment": "compartment_7660", "id": "reaction_10495850", "reactome": "R-DME-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10494968" ], "products": [ "species_113582", "species_10495848" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "FBgn0261278" ] }, "reaction_10494972": { "compartment": "compartment_7660", "id": "reaction_10494972", "reactome": "R-DME-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457959", "species_10494968" ], "products": [ "species_10494970" ], "modifiers": [], "additional_components": [ "FBgn0011763", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763" ] }, "reaction_10495839": { "compartment": "compartment_7660", "id": "reaction_10495839", "reactome": "R-DME-9007283", "name": "CBX3 and PRC1.6 associate with E2F6.com-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495835", "species_10494982", "species_10495829" ], "products": [ "species_10495837" ], "modifiers": [], "additional_components": [ "Q9VK33", "FBgn0032475", "Q9VB08", "FBgn0003330", "Q9W215", "FBgn0034763", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "M9PGH7", "FBgn0040372", "FBgn0039019", "Q9VCU6", "FBgn0039019", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "M9PGH7", "FBgn0040372", "Q9VK33", "FBgn0032475", "Q9VB08", "FBgn0003330", "Q9W215", "FBgn0034763" ] }, "reaction_10492290": { "compartment": "compartment_70101", "id": "reaction_10492290", "reactome": "R-DME-8937807", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492282", "species_113592" ], "products": [ "species_10492287", "species_29370", "species_10444503" ], "modifiers": [ [ "species_10492282", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "M9PI08", "FBgn0083981", "FBgn0083981", "FBgn0262733", "P00528", "FBgn0262733", "M9PI08", "FBgn0083981" ] }, "reaction_10492292": { "compartment": "compartment_70101", "id": "reaction_10492292", "reactome": "R-DME-8937814", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492280" ], "products": [ "species_10489801" ], "modifiers": [ [ "species_10437860", "catalyst" ], [ "species_10444503", "inhibitor" ] ], "additional_components": [ "FBgn0083981", "FBgn0083981", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "FBgn0262733" ] }, "reaction_10494821": { "compartment": "compartment_7660", "id": "reaction_10494821", "reactome": "R-DME-8952419", "name": "SMURFs ubiquitinate RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10489801" ], "products": [ "species_10494816" ], "modifiers": [ [ "species_10494818", "catalyst" ], [ "species_10458126", "inhibitor" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0083981", "FBgn0083981", "FBgn0029006", "FBgn0261617" ] }, "reaction_10492284": { "compartment": "compartment_70101", "id": "reaction_10492284", "reactome": "R-DME-8937792", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492280", "species_10444503" ], "products": [ "species_10492282" ], "modifiers": [], "additional_components": [ "FBgn0083981", "FBgn0262733", "P00528", "FBgn0262733", "M9PI08", "FBgn0083981" ] }, "reaction_10494812": { "compartment": "compartment_7660", "id": "reaction_10494812", "reactome": "R-DME-8952399", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494808" ], "products": [ "species_10494810" ], "modifiers": [], "additional_components": [ "FBgn0083981", "FBgn0083981" ] }, "reaction_10489805": { "compartment": "compartment_7660", "id": "reaction_10489805", "reactome": "R-DME-8865454", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10489782" ], "products": [ "species_10489803" ], "modifiers": [], "additional_components": [ "FBgn0083981", "FBgn0013753", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981" ] }, "reaction_10494814": { "compartment": "compartment_70101", "id": "reaction_10494814", "reactome": "R-DME-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494810" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "FBgn0083981", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10493669": { "compartment": "compartment_7660", "id": "reaction_10493669", "reactome": "R-DME-8951428", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468258", "species_10489801" ], "products": [ "species_10493667" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0083981", "M9PI08", "FBgn0083981", "P18824", "arm", "Q8IMA8", "FBgn0085432" ] }, "reaction_10445384": { "compartment": "compartment_7660", "id": "reaction_10445384", "reactome": "R-DME-376419", "name": "Formation of NR-MED1 Coactivator Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445380", "species_10445375" ], "products": [ "species_10445382" ], "modifiers": [], "additional_components": [ "FBgn0037109", "P13054", "FBgn0001323", "P16376", "FBgn0003651", "Q05192", "FBgn0261239", "P33244", "FBgn0001078", "Q24142", "FBgn0015239", "P49866", "FBgn0004914", "P49869", "FBgn0014859", "Q24143", "FBgn0015240", "P34021", "FBgn0000546", "A1ZA01", "FBgn0034012", "P18102", "FBgn0003720", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P31396", "FBgn0000448", "Q9Y0Y6", "FBgn0027497", "P45447", "FBgn0004865", "E1JHX0", "FBgn0260756", "Q8WS79", "FBgn0035849", "P13054", "FBgn0001323", "P16376", "FBgn0003651", "Q05192", "FBgn0261239", "P33244", "FBgn0001078", "Q24142", "FBgn0015239", "P49866", "FBgn0004914", "P49869", "FBgn0014859", "Q24143", "FBgn0015240", "P34021", "FBgn0000546", "A1ZA01", "FBgn0034012", "P18102", "FBgn0003720", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P31396", "FBgn0000448", "Q9Y0Y6", "FBgn0027497", "P45447", "FBgn0004865", "E1JHX0", "FBgn0260756", "Q8WS79", "FBgn0035849", "Q9VP05", "FBgn0037109" ] }, "reaction_10488872": { "compartment": "compartment_7660", "id": "reaction_10488872", "reactome": "R-DME-8853965", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488868", "species_10488864" ], "products": [ "species_10441673", "species_10488870" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0000529", "Q04787", "FBgn0000529", "Q8IMA8", "FBgn0085432" ] }, "reaction_10490422": { "compartment": "compartment_7660", "id": "reaction_10490422", "reactome": "R-DME-8869580", "name": "DEK binds TFAP2A homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489710", "species_10490418" ], "products": [ "species_10490420" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0026533", "Q8T0D3", "FBgn0026533", "M9PIH9", "FBgn0261953" ] }, "reaction_10489712": { "compartment": "compartment_7660", "id": "reaction_10489712", "reactome": "R-DME-8864278", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489702" ], "products": [ "species_10489710" ], "modifiers": [], "additional_components": [ "FBgn0261953", "M9PIH9", "FBgn0261953" ] }, "reaction_10489731": { "compartment": "compartment_70101", "id": "reaction_10489731", "reactome": "R-DME-8864577", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489725" ], "products": [ "species_10467863" ], "modifiers": [ [ "species_10489727", "inhibitor" ] ], "additional_components": [ "FBgn0261953", "FBgn0261953", "Q9VLU5", "FBgn0031972", "M9PIH9", "FBgn0261953" ] }, "reaction_10489743": { "compartment": "compartment_7660", "id": "reaction_10489743", "reactome": "R-DME-8864595", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489739", "species_10489737" ], "products": [ "species_10489741" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0031873", "Q9VM63", "FBgn0031873", "M9PIH9", "FBgn0261953" ] }, "reaction_10489729": { "compartment": "compartment_70101", "id": "reaction_10489729", "reactome": "R-DME-8864569", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489725", "species_10458536" ], "products": [ "species_10489727" ], "modifiers": [], "additional_components": [ "FBgn0261953", "FBgn0031972", "Q9VLU5", "FBgn0031972", "M9PIH9", "FBgn0261953" ] }, "reaction_10489721": { "compartment": "compartment_7660", "id": "reaction_10489721", "reactome": "R-DME-8864343", "name": "KCTD1 binds TFAP2 homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489710", "species_10489717" ], "products": [ "species_10489719" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0034636", "D5SHR0", "FBgn0034636", "M9PIH9", "FBgn0261953" ] }, "reaction_10489769": { "compartment": "compartment_7660", "id": "reaction_10489769", "reactome": "R-DME-8865265", "name": "TFAP2C homodimer binds MYC and KDM5B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467865", "species_10489765", "species_10489760" ], "products": [ "species_10489767" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0031759", "FBgn0262656", "Q9W4S7", "FBgn0262656", "Q9VMJ7", "FBgn0031759", "M9PIH9", "FBgn0261953" ] }, "reaction_10497665": { "compartment": "compartment_7660", "id": "reaction_10497665", "reactome": "R-DME-9620515", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10441099" ], "products": [ "species_2485002", "species_10497660" ], "modifiers": [ [ "species_10497662", "catalyst" ], [ "species_3785707", "catalyst" ] ], "additional_components": [ "Q9VTZ1", "FBgn0020388" ] }, "reaction_10497764": { "compartment": "compartment_7660", "id": "reaction_10497764", "reactome": "R-DME-9626928", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441097", "species_10447242" ], "products": [ "species_10497762" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9MS40", "FBgn0261617", "Q95V55", "foxo" ] }, "reaction_10497672": { "compartment": "compartment_7660", "id": "reaction_10497672", "reactome": "R-DME-9620532", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497660", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10441099" ], "modifiers": [ [ "species_10497669", "catalyst" ] ], "additional_components": [ "Q9I7I7", "FBgn0038788", "Q9VK34", "FBgn0024291" ] }, "reaction_10497573": { "compartment": "compartment_70101", "id": "reaction_10497573", "reactome": "R-DME-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497569", "species_10443103" ], "products": [ "species_10497571" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "Q95V55", "foxo", "P29310", "14-3-3zeta" ] }, "reaction_10497579": { "compartment": "compartment_70101", "id": "reaction_10497579", "reactome": "R-DME-9614562", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497563", "species_10497575" ], "products": [ "species_10497577" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "Q95V55", "foxo" ] }, "reaction_10497567": { "compartment": "compartment_7660", "id": "reaction_10497567", "reactome": "R-DME-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441108" ], "products": [ "species_10443103" ], "modifiers": [], "additional_components": [] }, "reaction_10497583": { "compartment": "compartment_70101", "id": "reaction_10497583", "reactome": "R-DME-9614564", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497565", "species_10432006" ], "products": [ "species_10497581" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "Q95V55", "foxo" ] }, "reaction_10497637": { "compartment": "compartment_7660", "id": "reaction_10497637", "reactome": "R-DME-9618021", "name": "FOXG1 binds FOXO:SMAD complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497628", "species_10497633" ], "products": [ "species_10497635" ], "modifiers": [], "additional_components": [ "Q95V55", "foxo", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0004567", "P32031", "FBgn0004567", "Q95V55", "foxo", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10497626": { "compartment": "compartment_7660", "id": "reaction_10497626", "reactome": "R-DME-9617996", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441097", "species_10437946" ], "products": [ "species_10497624" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q95V55", "foxo" ] }, "reaction_10434814": { "compartment": "compartment_7660", "id": "reaction_10434814", "reactome": "R-DME-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434775" ], "products": [ "species_10434775" ], "modifiers": [], "additional_components": [ "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10434808": { "compartment": "compartment_7660", "id": "reaction_10434808", "reactome": "R-DME-112437", "name": "Formation of NELF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434644", "species_10434629", "species_10434634", "species_10434639" ], "products": [ "species_10434646" ], "modifiers": [], "additional_components": [ "FBgn0017430", "FBgn0038872", "FBgn0027553", "FBgn0010416", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430" ] }, "reaction_10434806": { "compartment": "compartment_7660", "id": "reaction_10434806", "reactome": "R-DME-112436", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434710", "species_10434715" ], "products": [ "species_10434721" ], "modifiers": [], "additional_components": [ "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "FBgn0039066", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212" ] }, "reaction_10432469": { "compartment": "compartment_7660", "id": "reaction_10432469", "reactome": "R-DME-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432459" ], "products": [ "species_10432467" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10434804": { "compartment": "compartment_7660", "id": "reaction_10434804", "reactome": "R-DME-112435", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434708", "species_10434703" ], "products": [ "species_10434710" ], "modifiers": [], "additional_components": [ "FBgn0023212", "FBgn0266711", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212" ] }, "reaction_10434802": { "compartment": "compartment_7660", "id": "reaction_10434802", "reactome": "R-DME-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433111", "species_10434651" ], "products": [ "species_10434653" ], "modifiers": [], "additional_components": [ "FBgn0040273", "FBgn0028683", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273" ] }, "reaction_10434800": { "compartment": "compartment_7660", "id": "reaction_10434800", "reactome": "R-DME-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434608", "species_10434622" ], "products": [ "species_10434624" ], "modifiers": [], "additional_components": [ "FBgn0019949", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434798": { "compartment": "compartment_7660", "id": "reaction_10434798", "reactome": "R-DME-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434691", "species_10434696" ], "products": [ "species_10434698" ], "modifiers": [], "additional_components": [ "FBgn0010278", "FBgn0002183", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278" ] }, "reaction_10431436": { "compartment": "compartment_7660", "id": "reaction_10431436", "reactome": "R-DME-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431434" ], "products": [ "species_10431317", "species_10431174", "species_10431432", "species_10429256", "species_10431322", "species_109877", "species_10431420" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10432457": { "compartment": "compartment_7660", "id": "reaction_10432457", "reactome": "R-DME-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432455" ], "products": [ "species_10431317", "species_10431174", "species_10431432", "species_10429256", "species_10431322", "species_110068", "species_10431420" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10434822": { "compartment": "compartment_7660", "id": "reaction_10434822", "reactome": "R-DME-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434780" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434790": { "compartment": "compartment_7660", "id": "reaction_10434790", "reactome": "R-DME-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434788" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10432613": { "compartment": "compartment_7660", "id": "reaction_10432613", "reactome": "R-DME-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432611" ], "products": [ "species_10431174", "species_75897", "species_10431432", "species_10429256" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10434820": { "compartment": "compartment_7660", "id": "reaction_10434820", "reactome": "R-DME-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434780" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434786": { "compartment": "compartment_7660", "id": "reaction_10434786", "reactome": "R-DME-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434784" ], "products": [ "species_10434780" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434816": { "compartment": "compartment_7660", "id": "reaction_10434816", "reactome": "R-DME-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434784" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10433419": { "compartment": "compartment_7660", "id": "reaction_10433419", "reactome": "R-DME-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432082", "species_10431174" ], "products": [ "species_10432467" ], "modifiers": [], "additional_components": [ "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10433417": { "compartment": "compartment_7660", "id": "reaction_10433417", "reactome": "R-DME-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429256", "species_10432078" ], "products": [ "species_10432080" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10433415": { "compartment": "compartment_7660", "id": "reaction_10433415", "reactome": "R-DME-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431317", "species_10431322", "species_10432076" ], "products": [ "species_10432078" ], "modifiers": [], "additional_components": [ "P52654", "FBgn0011289", "P52656", "FBgn0013347", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10433413": { "compartment": "compartment_7660", "id": "reaction_10433413", "reactome": "R-DME-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10431420" ], "products": [ "species_10432076" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10432084": { "compartment": "compartment_7660", "id": "reaction_10432084", "reactome": "R-DME-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432080", "species_10431432" ], "products": [ "species_10432082" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10486881": { "compartment": "compartment_7660", "id": "reaction_10486881", "reactome": "R-DME-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10486869" ], "products": [ "species_113582", "species_10486878" ], "modifiers": [ [ "species_10486869", "catalyst" ] ], "additional_components": [ "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24216", "FBgn0263237", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24216", "FBgn0263237", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10486883": { "compartment": "compartment_7660", "id": "reaction_10486883", "reactome": "R-DME-6810238", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487478" ], "products": [ "species_10487486", "species_10487480" ], "modifiers": [ [ "species_10487478", "catalyst" ], [ "species_10430034", "catalyst" ], [ "species_10487492", "catalyst" ] ], "additional_components": [ "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "X2JAA3", "FBgn0032688", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", 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"FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", 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"FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "FBgn0264962", "FBgn0031054" ] }, "reaction_10487465": { "compartment": "compartment_7660", "id": "reaction_10487465", "reactome": "R-DME-6814549", "name": "Pre-snRNA transcript initiation, Integrator binding, LEC binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29470", "species_29358", "species_113562", "species_113571", "species_10487441", "species_10487456", "species_10487360" ], "products": [ "species_10487462" ], "modifiers": [ [ "species_10487360", "catalyst" ], [ "species_10434653", "catalyst" ] ], "additional_components": [ "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", 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demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "X2JAA3", "FBgn0032688", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10487630": { "compartment": "compartment_7660", "id": "reaction_10487630", "reactome": "R-DME-6814885", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429169", "species_10487498", "species_10440022", "species_10429515" ], "products": [ "species_10487478" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "X2JAA3", "FBgn0032688", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P04052", "FBgn0003277", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "species_430042", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "FBgn0033380", "FBgn0033062", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "X2JAA3", "FBgn0032688", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P04052", "FBgn0003277", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "species_430042", "Q9V9K7", "FBgn0033062", "A1Z7P3", "FBgn0033380", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10471026": { "compartment": "compartment_7660", "id": "reaction_10471026", "reactome": "R-DME-5221061", "name": "TDG excises 5-carboxylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5220996", "species_10433855" ], "products": [ "species_10433873", "species_5221064" ], "modifiers": [ [ "species_10433855", "catalyst" ] ], "additional_components": [ "FBgn0026869", "Q9V4D8", "FBgn0026869", "FBgn0026869" ] }, "reaction_10471024": { "compartment": "compartment_7660", "id": "reaction_10471024", "reactome": "R-DME-5220959", "name": "TDG excises 5-formylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5221062", "species_10433855" ], "products": [ "species_10433873", "species_5221065" ], "modifiers": [ [ "species_10433855", "catalyst" ] ], "additional_components": [ "FBgn0026869", "Q9V4D8", "FBgn0026869", "FBgn0026869" ] }, "reaction_209227": { "compartment": "compartment_70101", "id": "reaction_209227", "reactome": "R-DME-209227", "name": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The Drosophila orthologue of IKKB (IRD5) phosphorylates Relish (REL).", "reactants": [ "species_113592", "species_354323" ], "products": [ "species_29370", "species_354322" ], "modifiers": [ [ "species_206633", "catalyst" ] ], "additional_components": [ "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta" ] }, "reaction_214398": { "compartment": "compartment_70101", "id": "reaction_214398", "reactome": "R-DME-214398", "name": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The Drosophila orthologue of IKKB (IRD5) phosphorylates Relish (REL).", "reactants": [ "species_113592", "species_214406" ], "products": [ "species_29370", "species_214409" ], "modifiers": [ [ "species_206633", "catalyst" ] ], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta" ] }, "reaction_209200": { "compartment": "compartment_70101", "id": "reaction_209200", "reactome": "R-DME-209200", "name": "HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex", "reversible": "false", "notes": "MAP kinase kinase orthologue, the dual specificity kinase Hemipterous (HEP), is phosphorylated and activated in its activation loop at residues Ser348 and Thr352 by the MAP kinase kinase kinase orthologue, phosphorylated TAK1.", "reactants": [ "species_113592", "species_206293" ], "products": [ "species_29370", "species_205776" ], "modifiers": [ [ "species_206922", "catalyst" ] ], "additional_components": [ "P35128", "ben", "Q24307", "Diap2", "Q9V3Q6", "TAK1", "Q4TZQ4", "TAB2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209188": { "compartment": "compartment_70101", "id": "reaction_209188", "reactome": "R-DME-209188", "name": "TAK1-binding protein TAB2 binds to TAK1 kinase", "reversible": "false", "notes": "Areas in the C-terminal part of TAB2 (not the Zinc-finger domain) bind to TAK1 Ser/Thr kinase.", "reactants": [ "species_205754", "species_206059" ], "products": [ "species_206731" ], "modifiers": [], "additional_components": [ "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1" ] }, "reaction_209179": { "compartment": "compartment_70101", "id": "reaction_209179", "reactome": "R-DME-209179", "name": "IAP2:BEN:UEV1A E3 ligase complex auto-ubiquitinates", "reversible": "false", "notes": "The Apoptosis 2 Inhibitor (IAP2):Bendless (BEN):UEV1A E3 ubiquitin ligase complex autoubiquitinates, forming Lys63-linked ubiquitin chains.", "reactants": [ "species_206204", "species_207030" ], "products": [ "species_206608" ], "modifiers": [ [ "species_205735", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q9VRL1", "Uev1A", "P35128", "ben", "Q24307", "Diap2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209289": { "compartment": "compartment_70101", "id": "reaction_209289", "reactome": "R-DME-209289", "name": "TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase", "reversible": "false", "notes": "TAB2 in complex with TAK1 kinase binds to the ubiquitin chains emanating from the Apoptosis 2 Inhibitor (IAP2):Bendless (BEN):UEV1A E3 ligase complex. The formation of an E3 ligase:TAB2:TAK1 complex may cause conformational changes to the catalytic domain of TAK1 thus inducing its kinase activity.", "reactants": [ "species_206731", "species_206608" ], "products": [ "species_206764" ], "modifiers": [], "additional_components": [ "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "P35128", "ben", "Q24307", "Diap2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209320": { "compartment": "compartment_70101", "id": "reaction_209320", "reactome": "R-DME-209320", "name": "Activated TAK1 kinase is autophosphorylated", "reversible": "false", "notes": "TAK1 kinase is phosphorylated at Thr171 by another activated TAK1 kinase in an intermolecular autophosphorylation.", "reactants": [ "species_206764", "species_113592" ], "products": [ "species_29370", "species_206922" ], "modifiers": [ [ "species_206764", "catalyst" ] ], "additional_components": [ "P35128", "ben", "Q24307", "Diap2", "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q9V3Q6", "TAK1", "Q4TZQ4", "TAB2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209240": { "compartment": "compartment_70101", "id": "reaction_209240", "reactome": "R-DME-209240", "name": "Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5", "reversible": "false", "notes": "IRD5 is phosphorylated and activated by phosphorylated TAK1 kinase at residues Thr217 and Ser221 in the activation loop.", "reactants": [ "species_113592", "species_206628" ], "products": [ "species_29370", "species_206633" ], "modifiers": [ [ "species_206922", "catalyst" ] ], "additional_components": [ "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta", "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta", "P35128", "ben", "Q24307", "Diap2", "Q9V3Q6", "TAK1", "Q4TZQ4", "TAB2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_354273": { "compartment": "compartment_7660", "id": "reaction_354273", "reactome": "R-DME-354273", "name": "AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene", "reversible": "false", "notes": "When the JNK pathway is activated, the AP-1 transcription factor, a complex Jun-related antigen (JRA) and Kayak (KAY), forms a complex with the HMG protein, dorsal switch protein (DSP1) and STAT92E transcription factor (involved in the JAK/STAT pathway). This 'repressosome complex' and phosphorylated Relish (REL-68) are mutually exclusive in binding to this gene and so phosphorylated REL-68 is displaced from its target gene.", "reactants": [ "species_354268", "species_354285", "species_206244", "species_206724" ], "products": [ "species_354283", "species_354287", "species_354279" ], "modifiers": [], "additional_components": [ "O76216", "PCAF", "Q94527", "Rel", "P21525", "phospho-kay", "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q24151", "Stat92E", "Q24537", "Dsp1", "P18289", "phospho-Jra" ] }, "reaction_354289": { "compartment": "compartment_7660", "id": "reaction_354289", "reactome": "R-DME-354289", "name": "AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene", "reversible": "false", "notes": "The 'repressosome complex' recruits the histone deacetylase RPD3 aka HDAC1 to the Relish target gene resulting in repression of its transcription. This is an example of the JNK pathway downregulating the Imd pathway.", "reactants": [ "species_354283", "species_354293" ], "products": [ "species_354291" ], "modifiers": [], "additional_components": [ "P21525", "phospho-kay", "Q24151", "Stat92E", "Q24537", "Dsp1", "P18289", "phospho-Jra", "Q94517", "HDAC1", "P21525", "phospho-kay", "Q24151", "Stat92E", "Q24537", "Dsp1", "P18289", "phospho-Jra" ] }, "reaction_209257": { "compartment": "compartment_7660", "id": "reaction_209257", "reactome": "R-DME-209257", "name": "Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription", "reversible": "false", "notes": "In the nucleus, phosphorylated Relish (REL-68) forms a complex with the histone acetyltransferase, PCAF, at its target gene and transcription is activated.", "reactants": [ "species_354287", "species_354279" ], "products": [ "species_354285" ], "modifiers": [], "additional_components": [ "O76216", "PCAF", "Q94527", "Rel" ] }, "reaction_209309": { "compartment": "compartment_13231", "id": "reaction_209309", "reactome": "R-DME-209309", "name": "Phosphorylated REL-68 transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated N-terminal cleaved domain of Relish (REL-68) translocates from the cytosol to the nucleus. The corresponding phosphorylated C-terminal cleaved domain (REL-49) remains in the cytoplasm.", "reactants": [ "species_354270" ], "products": [ "species_354287" ], "modifiers": [], "additional_components": [] }, "reaction_10472558": { "compartment": "compartment_70101", "id": "reaction_10472558", "reactome": "R-DME-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10472555", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_1562550", "Q9I7K3", "FBgn0037818" ] }, "reaction_10472539": { "compartment": "compartment_876", "id": "reaction_10472539", "reactome": "R-DME-5433067", "name": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490235" ], "products": [ "species_266029", "species_5490250" ], "modifiers": [ [ "species_10443761", "catalyst" ] ], "additional_components": [ "CHEBI:78579", "CHEBI:78584", "CHEBI:78578", "CHEBI:78583", "Q9VBG1", "FBgn0039420", "X2JCU8", "FBgn0266100", "Q9VPG0", "FBgn0036986", "Q9VJ94", "FBgn0261804", "species_1562550" ] }, "reaction_10472537": { "compartment": "compartment_70101", "id": "reaction_10472537", "reactome": "R-DME-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10438532", "catalyst" ] ], "additional_components": [ "CHEBI:30725", "CHEBI:78586", "CHEBI:78581", "CHEBI:78587", "Q8SY19", "FBgn0025814" ] }, "reaction_10472548": { "compartment": "compartment_984", "id": "reaction_10472548", "reactome": "R-DME-5433072", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490253", "species_109276" ], "products": [ "species_210382", "species_5490235" ], "modifiers": [ [ "species_10472545", "catalyst" ] ], "additional_components": [ "CHEBI:78581", "CHEBI:78587", "CHEBI:78579", "CHEBI:78584", "Q7KUX2", "FBgn0030796", "M9NFP5", "FBgn0025837", "Q9VYR2", "FBgn0030361", "Q9VWT3", "FBgn0030932" ] }, "reaction_10486816": { "compartment": "compartment_17951", "id": "reaction_10486816", "reactome": "R-DME-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10486813", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VM80", "FBgn0031860" ] }, "reaction_10446586": { "compartment": "compartment_17951", "id": "reaction_10446586", "reactome": "R-DME-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_389678" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10446580", "catalyst" ] ], "additional_components": [ "species_76629", "A1Z8D3", "FBgn0061356" ] }, "reaction_10481081": { "compartment": "compartment_5460", "id": "reaction_10481081", "reactome": "R-DME-6793590", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478187", "species_10481070" ], "products": [ "species_10481073", "species_10436440" ], "modifiers": [ [ "species_10481078", "catalyst" ] ], "additional_components": [ "FBgn0027945", "CHEBI:25650", "Q94519", "FBgn0011361", "FBgn0027945", "FBgn0011361", "FBgn0037251" ] }, "reaction_10481048": { "compartment": "compartment_5460", "id": "reaction_10481048", "reactome": "R-DME-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481032", "species_10478185" ], "products": [ "species_10481040", "species_10478187" ], "modifiers": [ [ "species_10481045", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "species_8878387", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "species_113596", "Q9VVL7", "FBgn0036762", "Q9VM14", "FBgn0283658", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "Q9VA02", "FBgn0039827", "Q9VXY3", "FBgn0030612", "Q7PLE6", "FBgn0039993", "Q9VHB8", "FBgn0037709", "FBgn0027945", "Q9VA02", "FBgn0039827", "Q7PLE6", "FBgn0039993", "Q9VHB8", "FBgn0037709", "species_8878387", "Q9VXY3", "FBgn0030612", "species_113596", "Q9VVL7", "FBgn0036762", "Q9VM14", "FBgn0283658", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "FBgn0027945", "FBgn0265178" ] }, "reaction_10479511": { "compartment": "compartment_5460", "id": "reaction_10479511", "reactome": "R-DME-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784236", "species_113587" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10428224", "catalyst" ] ], "additional_components": [ "Q8IPY3", "FBgn0001125" ] }, "reaction_10446583": { "compartment": "compartment_17951", "id": "reaction_10446583", "reactome": "R-DME-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389822" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10446580", "catalyst" ] ], "additional_components": [ "species_76629", "A1Z8D3", "FBgn0061356" ] }, "reaction_10454421": { "compartment": "compartment_5460", "id": "reaction_10454421", "reactome": "R-DME-904864", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_904849", "species_379697" ], "products": [ "species_159549", "species_113557" ], "modifiers": [ [ "species_10454418", "catalyst" ] ], "additional_components": [ "A8E6R2", "FBgn0037186" ] }, "reaction_10479508": { "compartment": "compartment_5460", "id": "reaction_10479508", "reactome": "R-DME-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10479505", "catalyst" ] ], "additional_components": [ "Q04499", "FBgn0003423", "species_113596" ] }, "reaction_10446546": { "compartment": "compartment_17951", "id": "reaction_10446546", "reactome": "R-DME-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_193446" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10446543", "catalyst" ] ], "additional_components": [ "Q9VM80", "FBgn0031860", "Q7JZB1", "FBgn0033543", "species_113596" ] }, "reaction_10446507": { "compartment": "compartment_17951", "id": "reaction_10446507", "reactome": "R-DME-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_389664" ], "products": [ "species_389680", "species_193446" ], "modifiers": [ [ "species_10446504", "catalyst" ] ], "additional_components": [ "Q9W3Z3", "FBgn0014031" ] }, "reaction_10446571": { "compartment": "compartment_17951", "id": "reaction_10446571", "reactome": "R-DME-389826", "name": "glyoxylate + NADPH + H+ => glycolate + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_389678", "species_113602" ], "products": [ "species_389822", "species_389556" ], "modifiers": [ [ "species_10446568", "catalyst" ] ], "additional_components": [ "Q8INU6", "FBgn0051674", "Q8I725", "FBgn0037370", "Q9VII9", "FBgn0051673", "Q8SZU0", "FBgn0032889" ] }, "reaction_10481350": { "compartment": "compartment_70101", "id": "reaction_10481350", "reactome": "R-DME-6798317", "name": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_29424" ], "products": [ "species_5359017", "species_71285" ], "modifiers": [ [ "species_10481347", "catalyst" ] ], "additional_components": [ "Q9VG42", "FBgn0038074" ] }, "reaction_10478200": { "compartment": "compartment_5460", "id": "reaction_10478200", "reactome": "R-DME-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10478185" ], "products": [ "species_10478189", "species_29376" ], "modifiers": [ [ "species_10478197", "catalyst" ] ], "additional_components": [ "FBgn0027945", "Q9U616", "FBgn0027945", "CHEBI:14949", "Q9VH09", "FBgn0037801" ] }, "reaction_10478215": { "compartment": "compartment_5460", "id": "reaction_10478215", "reactome": "R-DME-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_10478202" ], "products": [ "species_113529", "species_10478185", "species_29362" ], "modifiers": [ [ "species_10478212", "catalyst" ] ], "additional_components": [ "Q9U616", "FBgn0027945", "CHEBI:50746", "FBgn0027945", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10478210": { "compartment": "compartment_5460", "id": "reaction_10478210", "reactome": "R-DME-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_10478189" ], "products": [ "species_5693978", "species_5693984", "species_10478202" ], "modifiers": [ [ "species_10478207", "catalyst" ] ], "additional_components": [ "Q9U616", "FBgn0027945", "CHEBI:14949", "Q9U616", "FBgn0027945", "CHEBI:50746", "FBgn0032287" ] }, "reaction_10481091": { "compartment": "compartment_5460", "id": "reaction_10481091", "reactome": "R-DME-6793591", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481073", "species_6793610", "species_2162265" ], "products": [ "species_379705", "species_6793613", "species_10478185" ], "modifiers": [ [ "species_10481088", "catalyst" ] ], "additional_components": [ "FBgn0027945", "FBgn0027945", "Q7JQW6", "FBgn0029158", "CHEBI:49883" ] }, "reaction_10428303": { "compartment": "compartment_5460", "id": "reaction_10428303", "reactome": "R-DME-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_379717" ], "products": [ "species_113529", "species_113590", "species_164934" ], "modifiers": [ [ "species_10428300", "catalyst" ] ], "additional_components": [ "FBgn0003423" ] }, "reaction_10495134": { "compartment": "compartment_5460", "id": "reaction_10495134", "reactome": "R-DME-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10479501", "catalyst" ] ], "additional_components": [ "FBgn0003423" ] }, "reaction_10444090": { "compartment": "compartment_70101", "id": "reaction_10444090", "reactome": "R-DME-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10444087", "catalyst" ] ], "additional_components": [ "FBgn0019932" ] }, "reaction_10444074": { "compartment": "compartment_70101", "id": "reaction_10444074", "reactome": "R-DME-351210", "name": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_204635" ], "products": [ "species_353560", "species_353106" ], "modifiers": [ [ "species_10444071", "catalyst" ] ], "additional_components": [ "FBgn0036272" ] }, "reaction_10444024": { "compartment": "compartment_70101", "id": "reaction_10444024", "reactome": "R-DME-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444018", "species_10444005" ], "products": [ "species_10444022" ], "modifiers": [], "additional_components": [ "P40807", "FBgn0013307", "P40808", "FBgn0013308", "P54361", "FBgn0014184", "P40808", "FBgn0013308", "P40807", "FBgn0013307", "P40808", "FBgn0013308", "P40807", "FBgn0013307", "P54361", "FBgn0014184" ] }, "reaction_10444007": { "compartment": "compartment_70101", "id": "reaction_10444007", "reactome": "R-DME-350567", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428317", "species_10443999" ], "products": [ "species_10444005" ], "modifiers": [], "additional_components": [ "P40808", "FBgn0013308", "P40807", "FBgn0013307", "FBgn0014184", "P54361", "FBgn0014184", "P40808", "FBgn0013308", "P40807", "FBgn0013307" ] }, "reaction_10444258": { "compartment": "compartment_70101", "id": "reaction_10444258", "reactome": "R-DME-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444005" ], "products": [ "species_10443999" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P54361", "FBgn0014184", "P40808", "FBgn0013308", "P40807", "FBgn0013307", "FBgn0014184", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10444012": { "compartment": "compartment_70101", "id": "reaction_10444012", "reactome": "R-DME-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10444009", "catalyst" ] ], "additional_components": [ "FBgn0013307" ] }, "reaction_10444082": { "compartment": "compartment_70101", "id": "reaction_10444082", "reactome": "R-DME-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_204635", "species_353106" ], "modifiers": [ [ "species_10444079", "catalyst" ] ], "additional_components": [ "FBgn0037723" ] }, "reaction_10428320": { "compartment": "compartment_70101", "id": "reaction_10428320", "reactome": "R-DME-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10428317", "catalyst" ] ], "additional_components": [ "P40808", "FBgn0013308", "P40807", "FBgn0013307" ] }, "reaction_10479998": { "compartment": "compartment_5460", "id": "reaction_10479998", "reactome": "R-DME-6788611", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788606", "species_113573" ], "products": [ "species_5696409", "species_113525" ], "modifiers": [ [ "species_10479995", "catalyst" ] ], "additional_components": [ "FBgn0086909" ] }, "reaction_10428637": { "compartment": "compartment_5460", "id": "reaction_10428637", "reactome": "R-DME-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70955" ], "products": [ "species_71045", "species_31649", "species_29376" ], "modifiers": [ [ "species_10428634", "catalyst" ] ], "additional_components": [ "Q9VMC6", "FBgn0031824", "species_113596" ] }, "reaction_10478071": { "compartment": "compartment_17951", "id": "reaction_10478071", "reactome": "R-DME-5693347", "name": "CRYM reduces P2C to PPCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_5693311", "species_113602" ], "products": [ "species_5693325", "species_389556" ], "modifiers": [ [ "species_10478068", "catalyst" ] ], "additional_components": [ "FBgn0030799" ] }, "reaction_10428486": { "compartment": "compartment_5460", "id": "reaction_10428486", "reactome": "R-DME-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113521", "species_30176" ], "products": [ "species_113529", "species_113556", "species_29362", "species_113552" ], "modifiers": [ [ "species_10428480", "catalyst" ] ], "additional_components": [ "Q9VLX0", "FBgn0286198" ] }, "reaction_10428483": { "compartment": "compartment_5460", "id": "reaction_10428483", "reactome": "R-DME-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113529", "species_29444", "species_113600" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10428480", "catalyst" ] ], "additional_components": [ "Q9VLX0", "FBgn0286198" ] }, "reaction_10428627": { "compartment": "compartment_5460", "id": "reaction_10428627", "reactome": "R-DME-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428624", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "species_8878387", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10428496": { "compartment": "compartment_5460", "id": "reaction_10428496", "reactome": "R-DME-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10428493", "catalyst" ] ], "additional_components": [ "Q8SXQ1", "FBgn0036857" ] }, "reaction_10444320": { "compartment": "compartment_5460", "id": "reaction_10444320", "reactome": "R-DME-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113577" ], "products": [ "species_29406", "species_70951" ], "modifiers": [ [ "species_10444317", "catalyst" ] ], "additional_components": [ "FBgn0040383" ] }, "reaction_10481307": { "compartment": "compartment_70101", "id": "reaction_10481307", "reactome": "R-DME-6797956", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618" ], "products": [ "species_6798162" ], "modifiers": [ [ "species_10481304", "catalyst" ] ], "additional_components": [ "FBgn0035523" ] }, "reaction_10481302": { "compartment": "compartment_5460", "id": "reaction_10481302", "reactome": "R-DME-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10428491", "catalyst" ] ], "additional_components": [ "FBgn0036857" ] }, "reaction_10481299": { "compartment": "compartment_5460", "id": "reaction_10481299", "reactome": "R-DME-6797913", "name": "SARDH:FAD oxidatively demethylates SARC to Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6797917", "species_113521" ], "products": [ "species_159549", "species_6797920" ], "modifiers": [ [ "species_10481296", "catalyst" ] ], "additional_components": [ "A1ZAZ2", "FBgn0034276", "species_113596" ] }, "reaction_10460684": { "compartment": "compartment_70101", "id": "reaction_10460684", "reactome": "R-DME-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10460681", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460713": { "compartment": "compartment_70101", "id": "reaction_10460713", "reactome": "R-DME-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_174369" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10460681", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460710": { "compartment": "compartment_70101", "id": "reaction_10460710", "reactome": "R-DME-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111707" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10460681", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10487305": { "compartment": "compartment_70101", "id": "reaction_10487305", "reactome": "R-DME-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_1655445", "species_70106" ], "modifiers": [ [ "species_10487302", "catalyst" ] ], "additional_components": [ "Q9VSD8", "FBgn0035839", "species_111793" ] }, "reaction_10487307": { "compartment": "compartment_70101", "id": "reaction_10487307", "reactome": "R-DME-6814165", "name": "PXLP-K333-GADL1 decarboxylates CSA to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787748" ], "products": [ "species_1655445", "species_113528" ], "modifiers": [ [ "species_10479955", "catalyst" ] ], "additional_components": [ "Q9VPH6", "FBgn0036975", "Q24062", "FBgn0000153" ] }, "reaction_10460723": { "compartment": "compartment_70101", "id": "reaction_10460723", "reactome": "R-DME-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10460720", "catalyst" ] ], "additional_components": [ "A1ZBA8", "FBgn0034364", "species_111793" ] }, "reaction_10460690": { "compartment": "compartment_70101", "id": "reaction_10460690", "reactome": "R-DME-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614582", "species_1614532" ], "modifiers": [ [ "species_10460681", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460671": { "compartment": "compartment_5460", "id": "reaction_10460671", "reactome": "R-DME-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_1614538", "species_113521" ], "products": [ "species_1614617", "species_1614584" ], "modifiers": [ [ "species_10460668", "catalyst" ] ], "additional_components": [ "Q9VWP4", "FBgn0030966", "species_947539" ] }, "reaction_10460708": { "compartment": "compartment_70616", "id": "reaction_10460708", "reactome": "R-DME-1614605", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_10460696", "species_113521" ], "products": [ "species_113529", "species_10460698", "species_1614538" ], "modifiers": [ [ "species_10460705", "catalyst" ] ], "additional_components": [ "FBgn0035515", "FBgn0035515", "Q86PD3", "FBgn0050022", "species_1562550" ] }, "reaction_10438434": { "compartment": "compartment_70101", "id": "reaction_10438434", "reactome": "R-DME-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_71285" ], "products": [ "species_83909", "species_174369" ], "modifiers": [ [ "species_10438431", "catalyst" ] ], "additional_components": [ "species_427523", "Q27580", "FBgn0014455" ] }, "reaction_10495325": { "compartment": "compartment_70101", "id": "reaction_10495325", "reactome": "R-DME-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357660", "species_29356", "species_113592" ], "products": [ "species_29372", "species_70106", "species_8959518", "species_76577" ], "modifiers": [ [ "species_10495322", "catalyst" ] ], "additional_components": [ "FBgn0261270" ] }, "reaction_10428174": { "compartment": "compartment_70101", "id": "reaction_10428174", "reactome": "R-DME-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29468" ], "products": [ "species_29514", "species_29498" ], "modifiers": [ [ "species_10428171", "catalyst" ] ], "additional_components": [ "O76895", "FBgn0023535", "species_266099" ] }, "reaction_10428184": { "compartment": "compartment_70101", "id": "reaction_10428184", "reactome": "R-DME-70573", "name": "argininosuccinate <=> fumarate + arginine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34575" ], "products": [ "species_29468", "species_29586" ], "modifiers": [ [ "species_10428181", "catalyst" ] ], "additional_components": [ "Q9VLG9", "FBgn0032076" ] }, "reaction_10451632": { "compartment": "compartment_5460", "id": "reaction_10451632", "reactome": "R-DME-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374064", "species_113521" ], "products": [ "species_374061", "species_113585" ], "modifiers": [ [ "species_10451629", "catalyst" ] ], "additional_components": [ "O76895", "FBgn0023535", "species_266099" ] }, "reaction_10428272": { "compartment": "compartment_70101", "id": "reaction_10428272", "reactome": "R-DME-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113567", "species_29498" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10428269", "catalyst" ] ], "additional_components": [ "FBgn0030218" ] }, "reaction_10428283": { "compartment": "compartment_5460", "id": "reaction_10428283", "reactome": "R-DME-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10428280", "catalyst" ] ], "additional_components": [ "Q9VW26", "FBgn0022774" ] }, "reaction_10453130": { "compartment": "compartment_5460", "id": "reaction_10453130", "reactome": "R-DME-508040", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113593", "species_113600", "species_113552" ], "products": [ "species_113548", "species_113581", "species_31339", "species_113563" ], "modifiers": [ [ "species_10453127", "catalyst" ] ], "additional_components": [ "Q9VNW6", "FBgn0037146" ] }, "reaction_10479495": { "compartment": "compartment_70101", "id": "reaction_10479495", "reactome": "R-DME-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_35305", "species_29364" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10479492", "catalyst" ] ], "additional_components": [ "Q9VEJ3", "FBgn0038516" ] }, "reaction_10428214": { "compartment": "compartment_5460", "id": "reaction_10428214", "reactome": "R-DME-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10428211", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_29362", "species_427523", "species_29366", "P54385", "FBgn0001098" ] }, "reaction_10428293": { "compartment": "compartment_5460", "id": "reaction_10428293", "reactome": "R-DME-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10428290", "catalyst" ] ], "additional_components": [ "Q9VEJ3", "FBgn0038516" ] }, "reaction_10428229": { "compartment": "compartment_5460", "id": "reaction_10428229", "reactome": "R-DME-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10428211", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_427523", "species_29366", "species_29364", "species_29362", "P54385", "FBgn0001098" ] }, "reaction_10454402": { "compartment": "compartment_70101", "id": "reaction_10454402", "reactome": "R-DME-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29472" ], "products": [ "species_29432", "species_893598" ], "modifiers": [ [ "species_10454393", "catalyst" ] ], "additional_components": [ "Q8SXC2", "FBgn0037955" ] }, "reaction_10479488": { "compartment": "compartment_5460", "id": "reaction_10479488", "reactome": "R-DME-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10479485", "catalyst" ] ], "additional_components": [ "Q9VEJ3", "FBgn0038516" ] }, "reaction_10428750": { "compartment": "compartment_5460", "id": "reaction_10428750", "reactome": "R-DME-71241", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113594", "species_35139" ], "products": [ "species_113546", "species_113536", "species_29376" ], "modifiers": [ [ "species_10428747", "catalyst" ] ], "additional_components": [ "species_351595", "Q9VDM7", "FBgn0038795", "species_111793" ] }, "reaction_10428761": { "compartment": "compartment_70101", "id": "reaction_10428761", "reactome": "R-DME-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_31311", "species_29424" ], "modifiers": [ [ "species_10428758", "catalyst" ] ], "additional_components": [ "Q9W457", "FBgn0029823" ] }, "reaction_10442782": { "compartment": "compartment_984", "id": "reaction_10442782", "reactome": "R-DME-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10478122": { "compartment": "compartment_876", "id": "reaction_10478122", "reactome": "R-DME-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352327" ], "products": [ "species_351628", "species_351629" ], "modifiers": [ [ "species_10478117", "catalyst" ] ], "additional_components": [ "FBgn0283531" ] }, "reaction_10442841": { "compartment": "compartment_984", "id": "reaction_10442841", "reactome": "R-DME-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352030", "species_209818", "species_351629" ], "products": [ "species_109276", "species_352329", "species_351628" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10444056": { "compartment": "compartment_984", "id": "reaction_10444056", "reactome": "R-DME-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_209818", "species_351629" ], "products": [ "species_109276", "species_351630", "species_351628" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10442823": { "compartment": "compartment_876", "id": "reaction_10442823", "reactome": "R-DME-209910", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10442820", "catalyst" ] ], "additional_components": [ "P83740", "FBgn0052669", "Q8SWV5", "FBgn0034494" ] }, "reaction_10442839": { "compartment": "compartment_984", "id": "reaction_10442839", "reactome": "R-DME-209960", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_352329" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10442830", "catalyst" ] ], "additional_components": [ "Q9VTE7", "FBgn0036125", "species_76629" ] }, "reaction_10442758": { "compartment": "compartment_984", "id": "reaction_10442758", "reactome": "R-DME-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351630", "species_352030" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10442837": { "compartment": "compartment_984", "id": "reaction_10442837", "reactome": "R-DME-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329", "species_351639" ], "products": [ "species_352331", "species_352036" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10442833": { "compartment": "compartment_984", "id": "reaction_10442833", "reactome": "R-DME-209921", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351639" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10442830", "catalyst" ] ], "additional_components": [ "Q9VTE7", "FBgn0036125", "species_76629" ] }, "reaction_10442808": { "compartment": "compartment_1462052", "id": "reaction_10442808", "reactome": "R-DME-209891", "name": "Dopamine is oxidised to noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351595", "species_351593", "species_351601" ], "products": [ "species_351599", "species_351597", "species_351603" ], "modifiers": [ [ "species_10442805", "catalyst" ] ], "additional_components": [ "CHEBI:28694", "Q86B61", "FBgn0010329", "CHEBI:18315" ] }, "reaction_10442835": { "compartment": "compartment_70101", "id": "reaction_10442835", "reactome": "R-DME-209924", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209849" ], "products": [ "species_113528", "species_159362" ], "modifiers": [ [ "species_10442795", "catalyst" ] ], "additional_components": [ "P05031", "FBgn0000422" ] }, "reaction_10442768": { "compartment": "compartment_70101", "id": "reaction_10442768", "reactome": "R-DME-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29506" ], "products": [ "species_209849", "species_71112" ], "modifiers": [ [ "species_10442765", "catalyst" ] ], "additional_components": [ "P18459", "FBgn0005626", "species_111793" ] }, "reaction_10443240": { "compartment": "compartment_17960", "id": "reaction_10443240", "reactome": "R-DME-211962", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_216621", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216612" ], "modifiers": [ [ "species_10443237", "catalyst" ] ], "additional_components": [ "Q27589", "FBgn0011576" ] }, "reaction_10443235": { "compartment": "compartment_17960", "id": "reaction_10443235", "reactome": "R-DME-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10443232", "catalyst" ] ], "additional_components": [ "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10443248": { "compartment": "compartment_17960", "id": "reaction_10443248", "reactome": "R-DME-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10443245", "catalyst" ] ], "additional_components": [ "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10443226": { "compartment": "compartment_5460", "id": "reaction_10443226", "reactome": "R-DME-211950", "name": "CYP24A1 24-hydroxylates CTL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_215607", "species_113600" ], "products": [ "species_113563", "species_215622", "species_113521" ], "modifiers": [ [ "species_10442747", "catalyst" ] ], "additional_components": [ "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053" ] }, "reaction_10442787": { "compartment": "compartment_70101", "id": "reaction_10442787", "reactome": "R-DME-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10442784", "catalyst" ] ], "additional_components": [ "FBgn0004959" ] }, "reaction_10443163": { "compartment": "compartment_12045", "id": "reaction_10443163", "reactome": "R-DME-211873", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266056", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2161636" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10472838": { "compartment": "compartment_12045", "id": "reaction_10472838", "reactome": "R-DME-5602295", "name": "CYP4F22 20-hydroxylates TrXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2142713", "species_29368", "species_29364" ], "products": [ "species_5602281", "species_29356", "species_29366" ], "modifiers": [ [ "species_10433053", "catalyst" ] ], "additional_components": [ "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397" ] }, "reaction_10443219": { "compartment": "compartment_17960", "id": "reaction_10443219", "reactome": "R-DME-211919", "name": "CYP4F8 19-hydroxylates PGH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30138", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215545" ], "modifiers": [ [ "species_10443216", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10443328": { "compartment": "compartment_17960", "id": "reaction_10443328", "reactome": "R-DME-215526", "name": "CYP4F3 20-hydroxylates LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215557", "species_113601" ], "products": [ "species_113519", "species_113564", "species_571314" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10435630": { "compartment": "compartment_70101", "id": "reaction_10435630", "reactome": "R-DME-158447", "name": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430485", "species_10435624" ], "products": [ "species_10432289", "species_10432313", "species_10435628" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "FBgn0003321", "FBgn0010774", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10433293": { "compartment": "compartment_7660", "id": "reaction_10433293", "reactome": "R-DME-77594", "name": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433289", "species_10429500", "species_10432253" ], "products": [ "species_10429169", "species_10433291", "species_10429982" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "FBgn0010774", "FBgn0003321", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435626": { "compartment": "compartment_13231", "id": "reaction_10435626", "reactome": "R-DME-158441", "name": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433291" ], "products": [ "species_10435624" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435660": { "compartment": "compartment_70101", "id": "reaction_10435660", "reactome": "R-DME-158484", "name": "Release of the SLBP independent Histone mRNA from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430485", "species_10435654" ], "products": [ "species_10432289", "species_10432313", "species_10435658" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "FBgn0003321", "FBgn0010774", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10434122": { "compartment": "compartment_7660", "id": "reaction_10434122", "reactome": "R-DME-111439", "name": "Docking of Mature Histone mRNA complex:TAP at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434114", "species_10429500", "species_10432253" ], "products": [ "species_10429169", "species_10434120" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "FBgn0010774", "FBgn0003321", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435656": { "compartment": "compartment_13231", "id": "reaction_10435656", "reactome": "R-DME-158481", "name": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434120" ], "products": [ "species_10435654" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10450430": { "compartment": "compartment_70101", "id": "reaction_10450430", "reactome": "R-DME-446185", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449703" ], "products": [ "species_532204" ], "modifiers": [ [ "species_10450427", "catalyst" ] ], "additional_components": [ "FBgn0036298" ] }, "reaction_10485958": { "compartment": "compartment_70101", "id": "reaction_10485958", "reactome": "R-DME-6803789", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6803743" ], "products": [ "species_193473", "species_449701" ], "modifiers": [ [ "species_10485955", "catalyst" ] ], "additional_components": [ "FBgn0031099" ] }, "reaction_10450504": { "compartment": "compartment_70101", "id": "reaction_10450504", "reactome": "R-DME-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_532204" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10450501", "catalyst" ] ], "additional_components": [ "Q9Y0Z0", "FBgn0259749" ] }, "reaction_10450806": { "compartment": "compartment_70101", "id": "reaction_10450806", "reactome": "R-DME-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10450803", "catalyst" ] ], "additional_components": [ "Q9VAW3", "FBgn0039580", "Q7PLC7", "FBgn0287209" ] }, "reaction_10485950": { "compartment": "compartment_70101", "id": "reaction_10485950", "reactome": "R-DME-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803785", "species_113592" ], "products": [ "species_6803738", "species_70106", "species_29370" ], "modifiers": [ [ "species_10485947", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "species_449703", "species_6803743", "Q9VF86", "FBgn0038321" ] }, "reaction_10450816": { "compartment": "compartment_70101", "id": "reaction_10450816", "reactome": "R-DME-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_449701" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10450813", "catalyst" ] ], "additional_components": [ "Q9VAI0", "FBgn0039690" ] }, "reaction_10457936": { "compartment": "compartment_1222693", "id": "reaction_10457936", "reactome": "R-DME-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10457933", "catalyst" ] ], "additional_components": [ "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "P23380", "FBgn0262736" ] }, "reaction_10465115": { "compartment": "compartment_12045", "id": "reaction_10465115", "reactome": "R-DME-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10465112", "catalyst" ] ], "additional_components": [ "Q9VXY0", "FBgn0030615", "Q9V557", "FBgn0033395", "Q9VLZ7", "FBgn0031925", "O46051", "FBgn0023541", "Q9VVN6", "FBgn0036778", "Q9V4T5", "FBgn0015034", "Q9VL92", "FBgn0015035", "Q9VS79", "FBgn0015033", "Q9V4T3", "FBgn0033292", "Q9VGH1", "FBgn0003312", "Q9VS78", "FBgn0035790", "Q27606", "FBgn0014469", "Q9V7G5", "FBgn0034053", "Q9VMS9", "FBgn0031693", "Q27589", "FBgn0011576", "Q9W011", "FBgn0035344", "Q9V559", "FBgn0033397", "Q9VMS8", "FBgn0031694", "P33269", "FBgn0005670", "Q9VYQ7", "FBgn0030367", "Q9V558", "FBgn0015037", "Q9VMS7", "FBgn0031695", "O46054", "FBgn0015036", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10465105": { "compartment": "compartment_12045", "id": "reaction_10465105", "reactome": "R-DME-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10465102", "catalyst" ] ], "additional_components": [ "Q9VXY0", "FBgn0030615", "Q9V557", "FBgn0033395", "Q9VLZ7", "FBgn0031925", "O46051", "FBgn0023541", "Q9VVN6", "FBgn0036778", "Q9V4T5", "FBgn0015034", "Q9VL92", "FBgn0015035", "Q9VS79", "FBgn0015033", "Q9V4T3", "FBgn0033292", "Q9VGH1", "FBgn0003312", "Q9VS78", "FBgn0035790", "Q27606", "FBgn0014469", "Q9V7G5", "FBgn0034053", "Q9VMS9", "FBgn0031693", "Q27589", "FBgn0011576", "Q9W011", "FBgn0035344", "Q9V559", "FBgn0033397", "Q9VMS8", "FBgn0031694", "P33269", "FBgn0005670", "Q9VYQ7", "FBgn0030367", "Q9V558", "FBgn0015037", "Q9VMS7", "FBgn0031695", "O46054", "FBgn0015036", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_350385": { "compartment": "compartment_876", "id": "reaction_350385", "reactome": "R-DME-350385", "name": "DSH binds to RAC1:GTP", "reversible": "false", "notes": "The DEP domain of Dishevelled (DSH) binds to activated Rac GTPase (RAC1:GTP).", "reactants": [ "species_351067", "species_450734" ], "products": [ "species_450786" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "P40792", "RAC1_DROME", "species_29438", "A1Z6W3", "PK" ] }, "reaction_450723": { "compartment": "compartment_70101", "id": "reaction_450723", "reactome": "R-DME-450723", "name": "RAC1:GTP and MSN activate HEP", "reversible": "false", "notes": "Activated RAC1:GTP and the MAP kinase kinase kinase kinase (MKKKK) orthologue Misshapen (MSN) are involved in phosphorylating and activating the MKK orthologue Hemipterous (HEP). It is likely that a MKKK orthologue, currently unknown, is involved in directly phosphorylating HEP.", "reactants": [ "species_113592", "species_206293" ], "products": [ "species_29370", "species_205776" ], "modifiers": [ [ "species_450710", "catalyst" ], [ "species_450786", "catalyst" ] ], "additional_components": [ "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "P40792", "RAC1_DROME", "species_29438", "A1Z6W3", "PK" ] }, "reaction_10450527": { "compartment": "compartment_12045", "id": "reaction_10450527", "reactome": "R-DME-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10450524", "catalyst" ] ], "additional_components": [ "FBgn0035401" ] }, "reaction_10450543": { "compartment": "compartment_17957", "id": "reaction_10450543", "reactome": "R-DME-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449315" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10450540", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0039293", "FBgn0031662" ] }, "reaction_10450494": { "compartment": "compartment_17957", "id": "reaction_10450494", "reactome": "R-DME-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10450491", "catalyst" ] ], "additional_components": [ "FBgn0032234" ] }, "reaction_10450535": { "compartment": "compartment_12045", "id": "reaction_10450535", "reactome": "R-DME-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_29410" ], "products": [ "species_532214", "species_110096" ], "modifiers": [ [ "species_10450532", "catalyst" ] ], "additional_components": [ "FBgn0261020" ] }, "reaction_10486907": { "compartment": "compartment_70101", "id": "reaction_10486907", "reactome": "R-DME-6810464", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410" ], "products": [ "species_29548", "species_109402" ], "modifiers": [ [ "species_10486904", "catalyst" ] ], "additional_components": [ "FBgn0261995" ] }, "reaction_10479928": { "compartment": "compartment_70101", "id": "reaction_10479928", "reactome": "R-DME-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10479925", "catalyst" ] ], "additional_components": [ "Q9W1X8", "FBgn0267823" ] }, "reaction_10479939": { "compartment": "compartment_70101", "id": "reaction_10479939", "reactome": "R-DME-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6787646", "species_29364" ], "products": [ "species_742368", "species_29366" ], "modifiers": [ [ "species_10479925", "catalyst" ] ], "additional_components": [ "Q9W1X8", "FBgn0267823" ] }, "reaction_10479936": { "compartment": "compartment_70101", "id": "reaction_10479936", "reactome": "R-DME-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_29356", "species_6787618" ], "modifiers": [ [ "species_10479933", "catalyst" ] ], "additional_components": [ "FBgn0031661" ] }, "reaction_10469805": { "compartment": "compartment_12045", "id": "reaction_10469805", "reactome": "R-DME-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10469802", "catalyst" ] ], "additional_components": [ "FBgn0032014" ] }, "reaction_10469797": { "compartment": "compartment_12045", "id": "reaction_10469797", "reactome": "R-DME-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_4419987" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10469794", "catalyst" ] ], "additional_components": [ "Q9W3M6", "FBgn0029980", "Q9VPX8", "FBgn0031312" ] }, "reaction_10450468": { "compartment": "compartment_12045", "id": "reaction_10450468", "reactome": "R-DME-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_449221" ], "products": [ "species_110094", "species_449299" ], "modifiers": [ [ "species_10450465", "catalyst" ] ], "additional_components": [ "FBgn0034141" ] }, "reaction_10450460": { "compartment": "compartment_12045", "id": "reaction_10450460", "reactome": "R-DME-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449299" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10450457", "catalyst" ] ], "additional_components": [ "FBgn0032477" ] }, "reaction_10450476": { "compartment": "compartment_17957", "id": "reaction_10450476", "reactome": "R-DME-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449312" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10450473", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0037743", "FBgn0031662" ] }, "reaction_10450443": { "compartment": "compartment_17957", "id": "reaction_10450443", "reactome": "R-DME-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449298" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10450435", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0011297", "FBgn0031662" ] }, "reaction_10450553": { "compartment": "compartment_12045", "id": "reaction_10450553", "reactome": "R-DME-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_29420", "species_449283" ], "modifiers": [ [ "species_10450550", "catalyst" ] ], "additional_components": [ "FBgn0038552" ] }, "reaction_10450519": { "compartment": "compartment_12045", "id": "reaction_10450519", "reactome": "R-DME-446207", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449222" ], "products": [ "species_449293", "species_110096" ], "modifiers": [ [ "species_10450516", "catalyst" ] ], "additional_components": [ "Q9VAP1", "FBgn0039639", "Q9VXU7", "FBgn0030645" ] }, "reaction_10450452": { "compartment": "compartment_17957", "id": "reaction_10450452", "reactome": "R-DME-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10450449", "catalyst" ] ], "additional_components": [ "FBgn0029906" ] }, "reaction_10450545": { "compartment": "compartment_17957", "id": "reaction_10450545", "reactome": "R-DME-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449371", "species_449311" ], "modifiers": [ [ "species_10450540", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0039293", "FBgn0031662" ] }, "reaction_10435743": { "compartment": "compartment_7660", "id": "reaction_10435743", "reactome": "R-DME-159101", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435738", "species_10432271" ], "products": [ "species_113550", "species_10432277", "species_10435740" ], "modifiers": [ [ "species_10435738", "catalyst" ] ], "additional_components": [ "Q02427", "FBgn0260944", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q9V3V0", "FBgn0028554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q9U1H9", "FBgn0003321", "Q9VV73", "FBgn0036640", "Q8IQK4", "FBgn0263232", "Q9V3H8", "FBgn0028411", "Q9U1H9", "FBgn0003321", "Q9VV73", "FBgn0036640", "Q8IQK4", "FBgn0263232", "Q9V3H8", "FBgn0028411", "Q02427", "FBgn0260944", "Q9VD52", "FBgn0038927", "Q9V3T8", "FBgn0265298", "Q9VY54", "FBgn0026713", "P26686", "FBgn0004587", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9V3E7", "FBgn0010774", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q27268", "FBgn0014189", "species_29370", "Q02427", "FBgn0260944", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q9V3V0", "FBgn0028554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411" ] }, "reaction_10432342": { "compartment": "compartment_70101", "id": "reaction_10432342", "reactome": "R-DME-75098", "name": "mRNP complex dissociates from cytosolic face of NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432329" ], "products": [ "species_10432243", "species_10432340", "species_10432301" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3H8", "FBgn0028411", "Q9VV73", "FBgn0036640", "Q9U1H9", "FBgn0003321", "Q8IQK4", "FBgn0263232", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VHC0", "FBgn0037707", "Q9V3E7", "FBgn0010774", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VHC0", "FBgn0037707", "Q9V3E7", "FBgn0010774", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3H8", "FBgn0028411", "Q9VV73", "FBgn0036640", "Q9U1H9", "FBgn0003321", "Q8IQK4", "FBgn0263232", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10432336": { "compartment": "compartment_13231", "id": "reaction_10432336", "reactome": "R-DME-75097", "name": "Transport of the export-competent mRNP complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432279" ], "products": [ "species_10432329" ], "modifiers": [ [ "species_10432243", "catalyst" ], [ "species_10432334", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9VV73", "FBgn0036640", "Q8IQK4", "FBgn0263232", "Q9V3H8", "FBgn0028411", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3H8", "FBgn0028411", "Q9VV73", "FBgn0036640", "Q9U1H9", "FBgn0003321", "Q8IQK4", "FBgn0263232", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VHC0", "FBgn0037707", "Q9V3E7", "FBgn0010774", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "FBgn0033316" ] }, "reaction_10439582": { "compartment": "compartment_17927", "id": "reaction_10439582", "reactome": "R-DME-189421", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189411" ], "products": [ "species_189481", "species_189480", "species_189478" ], "modifiers": [ [ "species_10439579", "catalyst" ] ], "additional_components": [ "Q9V3D2", "FBgn0021944" ] }, "reaction_10467261": { "compartment": "compartment_5460", "id": "reaction_10467261", "reactome": "R-DME-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10467258", "catalyst" ] ], "additional_components": [ "FBgn0034938" ] }, "reaction_10439612": { "compartment": "compartment_70101", "id": "reaction_10439612", "reactome": "R-DME-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_29356", "species_70106", "species_189464" ], "modifiers": [ [ "species_10439609", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VTV9", "FBgn0036271" ] }, "reaction_10439640": { "compartment": "compartment_5460", "id": "reaction_10439640", "reactome": "R-DME-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_113529", "species_189444" ], "modifiers": [ [ "species_10439637", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "Q9V9S8", "FBgn0266268" ] }, "reaction_10455127": { "compartment": "compartment_876", "id": "reaction_10455127", "reactome": "R-DME-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_71185" ], "products": [ "species_29372", "species_917877", "species_29370" ], "modifiers": [ [ "species_10455124", "catalyst" ] ], "additional_components": [ "P45843", "FBgn0003515", "P12428", "FBgn0000241", "Q0KI14", "FBgn0051121" ] }, "reaction_10467253": { "compartment": "compartment_5460", "id": "reaction_10467253", "reactome": "R-DME-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10467250", "catalyst" ] ], "additional_components": [ "FBgn0032222" ] }, "reaction_10439572": { "compartment": "compartment_70101", "id": "reaction_10439572", "reactome": "R-DME-189406", "name": "4 PBGs bind to form HMB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_189464" ], "products": [ "species_189449", "species_31633" ], "modifiers": [ [ "species_10439569", "catalyst" ] ], "additional_components": [ "Q9W0G4", "FBgn0010786", "CHEBI:36319" ] }, "reaction_10439602": { "compartment": "compartment_70101", "id": "reaction_10439602", "reactome": "R-DME-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_189455", "species_113528" ], "modifiers": [ [ "species_10439599", "catalyst" ] ], "additional_components": [ "Q9V595", "FBgn0033428" ] }, "reaction_10439630": { "compartment": "compartment_5460", "id": "reaction_10439630", "reactome": "R-DME-189442", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_70958", "species_113529" ], "products": [ "species_29374", "species_189466", "species_29376" ], "modifiers": [ [ "species_10439627", "catalyst" ], [ "species_189444", "inhibitor" ] ], "additional_components": [ "O18680", "FBgn0020764" ] }, "reaction_10439592": { "compartment": "compartment_17927", "id": "reaction_10439592", "reactome": "R-DME-189423", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189478" ], "products": [ "species_189481", "species_189463" ], "modifiers": [ [ "species_10439589", "catalyst" ] ], "additional_components": [ "Q9VC52", "FBgn0020018", "species_113596" ] }, "reaction_10439654": { "compartment": "compartment_70101", "id": "reaction_10439654", "reactome": "R-DME-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10439599", "catalyst" ] ], "additional_components": [ "Q9V595", "FBgn0033428" ] }, "reaction_10439652": { "compartment": "compartment_70101", "id": "reaction_10439652", "reactome": "R-DME-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10439609" ], "products": [ "species_10439650", "species_29426" ], "modifiers": [], "additional_components": [ "species_1562550", "Q9VTV9", "FBgn0036271", "species_1562550", "Q9VTV9", "FBgn0036271", "species_190173" ] }, "reaction_10439648": { "compartment": "compartment_70101", "id": "reaction_10439648", "reactome": "R-DME-189488", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189449" ], "products": [ "species_189407", "species_29356" ], "modifiers": [ [ "species_10439645", "catalyst" ] ], "additional_components": [ "FBgn0030066" ] }, "reaction_10453037": { "compartment": "compartment_876", "id": "reaction_10453037", "reactome": "R-DME-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10453034", "catalyst" ] ], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "Q8IRI6", "FBgn0264574" ] }, "reaction_10447180": { "compartment": "compartment_876", "id": "reaction_10447180", "reactome": "R-DME-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10447177", "catalyst" ] ], "additional_components": [ "species_29438" ] }, "reaction_10443692": { "compartment": "compartment_876", "id": "reaction_10443692", "reactome": "R-DME-265645", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10443689", "catalyst" ] ], "additional_components": [ "X2J9Z3", "FBgn0028863", "Q8IP22", "FBgn0261999", "Q24270", "FBgn0001991", "P91645", "FBgn0263111" ] }, "reaction_10449645": { "compartment": "compartment_876", "id": "reaction_10449645", "reactome": "R-DME-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10449642", "catalyst" ] ], "additional_components": [ "FBgn0035815" ] }, "reaction_10447214": { "compartment": "compartment_876", "id": "reaction_10447214", "reactome": "R-DME-400092", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447212" ], "products": [ "species_29420", "species_10447204" ], "modifiers": [ [ "species_10445696", "catalyst" ] ], "additional_components": [ "species_29420", "species_29438", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10447208": { "compartment": "compartment_876", "id": "reaction_10447208", "reactome": "R-DME-400071", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10445692" ], "products": [ "species_10445696" ], "modifiers": [], "additional_components": [ "CHEBI:28918", "species_351597", "FBgn0004514", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10447206": { "compartment": "compartment_876", "id": "reaction_10447206", "reactome": "R-DME-400037", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447204" ], "products": [ "species_10447202", "species_10447196" ], "modifiers": [], "additional_components": [ "species_29438", "species_29438" ] }, "reaction_10447221": { "compartment": "compartment_876", "id": "reaction_10447221", "reactome": "R-DME-400097", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447217", "species_10447202" ], "products": [ "species_10447219" ], "modifiers": [], "additional_components": [] }, "reaction_10446063": { "compartment": "compartment_70101", "id": "reaction_10446063", "reactome": "R-DME-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10446061" ], "products": [ "species_29420", "species_10444262" ], "modifiers": [ [ "species_10446032", "catalyst" ], [ "species_10446001", "catalyst" ] ], "additional_components": [ "species_29420", "P08645", "FBgn0004636", "P08645", "FBgn0004636", "species_29438", "A1Z6P8", "FBgn0085421", "species_30389", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10446059": { "compartment": "compartment_876", "id": "reaction_10446059", "reactome": "R-DME-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446057" ], "products": [ "species_10446057" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "P17970", "FBgn0262593", "P17972", "FBgn0003386", "A8DYR5", "FBgn0085395", "P17970", "FBgn0262593", "P17972", "FBgn0003386", "A8DYR5", "FBgn0085395", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10446027": { "compartment": "compartment_12045", "id": "reaction_10446027", "reactome": "R-DME-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446017" ], "products": [ "species_10446025" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "P29993", "FBgn0010051", "P29993", "FBgn0010051", "species_114520", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10446003": { "compartment": "compartment_876", "id": "reaction_10446003", "reactome": "R-DME-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10445999" ], "products": [ "species_10446001" ], "modifiers": [], "additional_components": [ "FBgn0085421", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10446034": { "compartment": "compartment_876", "id": "reaction_10446034", "reactome": "R-DME-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10446030" ], "products": [ "species_10446032" ], "modifiers": [], "additional_components": [ "FBgn0085421", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10430876": { "compartment": "compartment_70101", "id": "reaction_10430876", "reactome": "R-DME-73567", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111294", "species_111629" ], "modifiers": [ [ "species_10430870", "catalyst" ] ], "additional_components": [ "Q01637", "FBgn0003257" ] }, "reaction_10430873": { "compartment": "compartment_70101", "id": "reaction_10430873", "reactome": "R-DME-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10430870", "catalyst" ] ], "additional_components": [ "Q01637", "FBgn0003257" ] }, "reaction_10430902": { "compartment": "compartment_70101", "id": "reaction_10430902", "reactome": "R-DME-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592", "species_29472" ], "products": [ "species_111647", "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10430893", "catalyst" ] ], "additional_components": [ "P05990", "FBgn0003189" ] }, "reaction_10430886": { "compartment": "compartment_70101", "id": "reaction_10430886", "reactome": "R-DME-73569", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_76630" ], "products": [ "species_76632", "species_76633" ], "modifiers": [ [ "species_10430883", "catalyst" ] ], "additional_components": [ "species_76629", "P32748", "FBgn0000447" ] }, "reaction_10430899": { "compartment": "compartment_70101", "id": "reaction_10430899", "reactome": "R-DME-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111647", "species_29448" ], "products": [ "species_111628", "species_29372" ], "modifiers": [ [ "species_10430893", "catalyst" ] ], "additional_components": [ "P05990", "FBgn0003189" ] }, "reaction_10430896": { "compartment": "compartment_70101", "id": "reaction_10430896", "reactome": "R-DME-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111628", "species_70106" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10430893", "catalyst" ] ], "additional_components": [ "P05990", "FBgn0003189" ] }, "reaction_10490053": { "compartment": "compartment_7660", "id": "reaction_10490053", "reactome": "R-DME-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567" ], "modifiers": [ [ "species_10490050", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "Q9VVY4", "FBgn0028380", "species_1562550" ] }, "reaction_10430942": { "compartment": "compartment_70101", "id": "reaction_10430942", "reactome": "R-DME-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73588" ], "products": [ "species_113528", "species_73590", "species_31633" ], "modifiers": [ [ "species_10430939", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VI04", "FBgn0037513" ] }, "reaction_10430974": { "compartment": "compartment_70101", "id": "reaction_10430974", "reactome": "R-DME-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83960", "species_29364" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10430919", "catalyst" ] ], "additional_components": [ "species_76629", "Q9W374", "FBgn0086450", "species_113596" ] }, "reaction_10431581": { "compartment": "compartment_70101", "id": "reaction_10431581", "reactome": "R-DME-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_83962", "species_500244" ], "modifiers": [ [ "species_10431576", "catalyst" ] ], "additional_components": [ "CHEBI:16450", "CHEBI:16704", "CHEBI:28542", "species_112016", "Q9VBA0", "FBgn0039464", "Q8T8S2", "FBgn0034800", "Q0E8U4", "FBgn0031489" ] }, "reaction_10433355": { "compartment": "compartment_70101", "id": "reaction_10433355", "reactome": "R-DME-109449", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10433352", "catalyst" ] ], "additional_components": [ "species_1524067", "CHEBI:15918", "species_109366", "species_109382", "species_418075", "CHEBI:15698", "CHEBI:16450", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_29926", "Q9W197", "FBgn0034988" ] }, "reaction_10430922": { "compartment": "compartment_70101", "id": "reaction_10430922", "reactome": "R-DME-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83962", "species_29364" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10430919", "catalyst" ] ], "additional_components": [ "species_76629", "Q9W374", "FBgn0086450", "species_113596" ] }, "reaction_10433333": { "compartment": "compartment_984", "id": "reaction_10433333", "reactome": "R-DME-109291", "name": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_500316" ], "products": [ "species_109277", "species_500318" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_418075", "species_1524067", "species_109366", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10430932": { "compartment": "compartment_70101", "id": "reaction_10430932", "reactome": "R-DME-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_73588" ], "modifiers": [ [ "species_10430929", "catalyst" ] ], "additional_components": [ "Q8IPQ2", "FBgn0023023", "species_1562550" ] }, "reaction_10430978": { "compartment": "compartment_70101", "id": "reaction_10430978", "reactome": "R-DME-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73617" ], "products": [ "species_113528", "species_73619", "species_31633" ], "modifiers": [ [ "species_10430939", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VI04", "FBgn0037513" ] }, "reaction_10430976": { "compartment": "compartment_70101", "id": "reaction_10430976", "reactome": "R-DME-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73541" ], "products": [ "species_73617" ], "modifiers": [ [ "species_10430929", "catalyst" ] ], "additional_components": [ "Q8IPQ2", "FBgn0023023", "species_1562550" ] }, "reaction_10488423": { "compartment": "compartment_984", "id": "reaction_10488423", "reactome": "R-DME-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8936165" ], "products": [ "species_8851369", "species_109277" ], "modifiers": [ [ "species_10488420", "catalyst" ] ], "additional_components": [ "species_29370", "species_205687", "species_29420", "species_110094", "species_418075", "species_1524067", "species_5696194", "species_76577", "M9PBV2", "FBgn0024947", "species_29926", "species_74016" ] }, "reaction_10488430": { "compartment": "compartment_984", "id": "reaction_10488430", "reactome": "R-DME-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8851462" ], "products": [ "species_109277", "species_8851461" ], "modifiers": [ [ "species_10488427", "catalyst" ] ], "additional_components": [ "CHEBI:17808", "species_205687", "species_29420", "species_110094", "species_418075", "species_29602", "species_1524067", "species_5696194", "species_29926", "species_74016", "M9PBV2", "FBgn0024947" ] }, "reaction_10498277": { "compartment": "compartment_17957", "id": "reaction_10498277", "reactome": "R-DME-9650473", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498275" ], "products": [ "species_10452491" ], "modifiers": [], "additional_components": [ "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930" ] }, "reaction_10472854": { "compartment": "compartment_984", "id": "reaction_10472854", "reactome": "R-DME-5607023", "name": "factor IXa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435383" ], "products": [ "species_10472852" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10498442": { "compartment": "compartment_17957", "id": "reaction_10498442", "reactome": "R-DME-9670673", "name": "FIX is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498440" ], "products": [ "species_10435369" ], "modifiers": [], "additional_components": [ "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459" ] }, "reaction_10478063": { "compartment": "compartment_984", "id": "reaction_10478063", "reactome": "R-DME-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_83908" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10478060", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VVK5", "FBgn0036752" ] }, "reaction_10497731": { "compartment": "compartment_12045", "id": "reaction_10497731", "reactome": "R-DME-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497729" ], "products": [ "species_10476466" ], "modifiers": [], "additional_components": [ "FBgn0000416", "FBgn0000416" ] }, "reaction_10476537": { "compartment": "compartment_3828046", "id": "reaction_10476537", "reactome": "R-DME-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476466", "species_5685882" ], "products": [ "species_10476468", "species_10476470", "species_10476472" ], "modifiers": [ [ "species_10476534", "catalyst" ] ], "additional_components": [ "FBgn0000416", "FBgn0000416", "FBgn0000416", "FBgn0000416", "Q9VLK3", "FBgn0032049", "Q9VKP7", "FBgn0032303", "Q9VKP6", "FBgn0032304", "Q9VEK4", "FBgn0038506", "Q9W5G3", "FBgn0011822", "Q9VEK3", "FBgn0038507", "Q9VQ14", "FBgn0053128", "Q7K485", "FBgn0029093", "Q9VQ13", "FBgn0051926", "A1Z9Q9", "FBgn0033933", "Q9VQ12", "FBgn0053128", "Q9VQ11", "FBgn0051928", "Q9VNK6", "FBgn0037396" ] }, "reaction_10480360": { "compartment": "compartment_3828046", "id": "reaction_10480360", "reactome": "R-DME-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476468" ], "products": [ "species_10476539" ], "modifiers": [], "additional_components": [ "FBgn0000416", "Q9Y125", "FBgn0000416" ] }, "reaction_10476405": { "compartment": "compartment_7660", "id": "reaction_10476405", "reactome": "R-DME-5683888", "name": "LMCD1 binds GATA6, sequestering it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476401", "species_10457526" ], "products": [ "species_10476403" ], "modifiers": [], "additional_components": [ "FBgn0034223", "Q9VF00", "FBgn0038391", "P52168", "FBgn0003117", "Q9VF00", "FBgn0038391", "P52168", "FBgn0003117", "A1ZAT5", "FBgn0034223" ] }, "reaction_10498522": { "compartment": "compartment_7660", "id": "reaction_10498522", "reactome": "R-DME-9679787", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498518", "species_9679795" ], "products": [ "species_10498520" ], "modifiers": [], "additional_components": [ "Q9VXB3", "FBgn0030788", "Q94517", "HDAC1", "Q9VWP5", "FBgn0085451", "Q9VWG2", "FBgn0031036", "Q9VEX9", "FBgn0024491", "Q24572", "FBgn0263979", "Q9VYI2", "FBgn0030434", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397", "Q9VK36", "FBgn0032473", "Q8T092", "FBgn0034114", "Q9VRV0", "FBgn0035687", "Q9VH18", "FBgn0037794", "Q9W137", "FBgn0035036", "Q9VIS9", "FBgn0032814", "A1ZBC5", "FBgn0034379", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q9VXB3", "FBgn0030788", "Q94517", "HDAC1", "Q9VWP5", "FBgn0085451", "Q9VWG2", "FBgn0031036", "Q9VEX9", "FBgn0024491", "Q24572", "FBgn0263979", "Q9VYI2", "FBgn0030434", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397", "Q9VK36", "FBgn0032473", "Q8T092", "FBgn0034114", "Q9VRV0", "FBgn0035687", "Q9VH18", "FBgn0037794", "Q9W137", "FBgn0035036", "Q9VIS9", "FBgn0032814", "A1ZBC5", "FBgn0034379", "O97159", "FBgn0262519", "O16102", "FBgn0023395" ] }, "reaction_10461614": { "compartment": "compartment_7660", "id": "reaction_10461614", "reactome": "R-DME-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461741": { "compartment": "compartment_7660", "id": "reaction_10461741", "reactome": "R-DME-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461580": { "compartment": "compartment_7660", "id": "reaction_10461580", "reactome": "R-DME-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10461577", "catalyst" ] ], "additional_components": [ "FBgn0050295" ] }, "reaction_10461738": { "compartment": "compartment_7660", "id": "reaction_10461738", "reactome": "R-DME-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023892" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461658": { "compartment": "compartment_7660", "id": "reaction_10461658", "reactome": "R-DME-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461529": { "compartment": "compartment_7660", "id": "reaction_10461529", "reactome": "R-DME-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461655": { "compartment": "compartment_7660", "id": "reaction_10461655", "reactome": "R-DME-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461747": { "compartment": "compartment_7660", "id": "reaction_10461747", "reactome": "R-DME-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461729": { "compartment": "compartment_7660", "id": "reaction_10461729", "reactome": "R-DME-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461632": { "compartment": "compartment_7660", "id": "reaction_10461632", "reactome": "R-DME-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023935" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461567": { "compartment": "compartment_70101", "id": "reaction_10461567", "reactome": "R-DME-1855166", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023943" ], "products": [ "species_29372", "species_994141" ], "modifiers": [ [ "species_10461555", "catalyst" ] ], "additional_components": [ "species_1629736", "species_2023922", "CHEBI:62927", "species_29926", "species_266099", "Q7JVG2", "FBgn0036111" ] }, "reaction_10461726": { "compartment": "compartment_70101", "id": "reaction_10461726", "reactome": "R-DME-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461564": { "compartment": "compartment_70101", "id": "reaction_10461564", "reactome": "R-DME-1855165", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_1629765", "species_29372" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "species_2023931", "CHEBI:62924", "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10461624": { "compartment": "compartment_70101", "id": "reaction_10461624", "reactome": "R-DME-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10461619", "catalyst" ] ], "additional_components": [ "FBgn0027279" ] }, "reaction_10463703": { "compartment": "compartment_70101", "id": "reaction_10463703", "reactome": "R-DME-2023973", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_29372", "species_2023974" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "species_2023931", "CHEBI:62924", "species_2023932", "CHEBI:62922", "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10463701": { "compartment": "compartment_70101", "id": "reaction_10463701", "reactome": "R-DME-2023971", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023974" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "species_2023932", "CHEBI:62922", "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10461641": { "compartment": "compartment_70101", "id": "reaction_10461641", "reactome": "R-DME-1855198", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_29356" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10461608": { "compartment": "compartment_70101", "id": "reaction_10461608", "reactome": "R-DME-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10461605", "catalyst" ] ], "additional_components": [ "FBgn0050295" ] }, "reaction_10461735": { "compartment": "compartment_70101", "id": "reaction_10461735", "reactome": "R-DME-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461638": { "compartment": "compartment_70101", "id": "reaction_10461638", "reactome": "R-DME-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461701": { "compartment": "compartment_70101", "id": "reaction_10461701", "reactome": "R-DME-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10461619", "catalyst" ] ], "additional_components": [ "FBgn0027279" ] }, "reaction_10461635": { "compartment": "compartment_70101", "id": "reaction_10461635", "reactome": "R-DME-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461536": { "compartment": "compartment_70101", "id": "reaction_10461536", "reactome": "R-DME-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10442750": { "compartment": "compartment_70616", "id": "reaction_10442750", "reactome": "R-DME-209765", "name": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_209800", "species_29368", "species_29364" ], "products": [ "species_29356", "species_350159", "species_29366" ], "modifiers": [ [ "species_10442747", "catalyst" ], [ "species_29532", "catalyst" ] ], "additional_components": [ "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053" ] }, "reaction_10495353": { "compartment": "compartment_161320", "id": "reaction_10495353", "reactome": "R-DME-8963864", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495351" ], "products": [ "species_350136", "species_10495349" ], "modifiers": [], "additional_components": [ "A8JQY3", "FBgn0085431", "species_8963879", "FBgn0085431" ] }, "reaction_10495357": { "compartment": "compartment_7660", "id": "reaction_10495357", "reactome": "R-DME-8963915", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445234", "species_8963912" ], "products": [ "species_10495355" ], "modifiers": [], "additional_components": [ "FBgn0015240", "species_8963912", "Q24143", "FBgn0015240" ] }, "reaction_10460847": { "compartment": "compartment_70101", "id": "reaction_10460847", "reactome": "R-DME-1655831", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460835" ], "products": [ "species_10460845" ], "modifiers": [], "additional_components": [ "O18388", "FBgn0262743", "Q9VW37", "FBgn0261283", "Q9VW37", "FBgn0261283", "O18388", "FBgn0262743" ] }, "reaction_10464750": { "compartment": "compartment_70101", "id": "reaction_10464750", "reactome": "R-DME-2065549", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460827" ], "products": [ "species_10460833" ], "modifiers": [], "additional_components": [ "FBgn0261283", "Q9VW37", "FBgn0261283" ] }, "reaction_10464748": { "compartment": "compartment_7660", "id": "reaction_10464748", "reactome": "R-DME-2065539", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442310", "species_10460845" ], "products": [ "species_10464746", "species_10460843" ], "modifiers": [], "additional_components": [ "species_29438", "Q9VZ23", "FBgn0020255", "Q9VW37", "FBgn0261283", "O18388", "FBgn0262743", "O18388", "FBgn0262743", "species_29438", "Q9VZ23", "FBgn0020255", "Q9VW37", "FBgn0261283" ] }, "reaction_10460870": { "compartment": "compartment_20699", "id": "reaction_10460870", "reactome": "R-DME-1655851", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460862" ], "products": [ "species_10460827" ], "modifiers": [ [ "species_10447716", "catalyst" ] ], "additional_components": [ "FBgn0261283", "FBgn0261283", "FBgn0033656" ] }, "reaction_10460868": { "compartment": "compartment_20699", "id": "reaction_10460868", "reactome": "R-DME-1655842", "name": "S1P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460860" ], "products": [ "species_10460858", "species_10460862" ], "modifiers": [ [ "species_10445971", "catalyst" ] ], "additional_components": [ "A1Z6J2", "FBgn0033052", "Q9VW37", "FBgn0261283", "A1Z6J2", "FBgn0033052", "FBgn0261283", "FBgn0037105" ] }, "reaction_10464752": { "compartment": "compartment_70101", "id": "reaction_10464752", "reactome": "R-DME-2065550", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460833", "species_10443115" ], "products": [ "species_10460835" ], "modifiers": [], "additional_components": [ "Q9VW37", "FBgn0261283", "FBgn0262743", "O18388", "FBgn0262743", "Q9VW37", "FBgn0261283" ] }, "reaction_10446655": { "compartment": "compartment_17951", "id": "reaction_10446655", "reactome": "R-DME-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10446652", "catalyst" ] ], "additional_components": [ "FBgn0039131" ] }, "reaction_10487936": { "compartment": "compartment_12045", "id": "reaction_10487936", "reactome": "R-DME-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10446670": { "compartment": "compartment_17951", "id": "reaction_10446670", "reactome": "R-DME-390438", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10446667", "catalyst" ] ], "additional_components": [ "Q9VES6", "FBgn0038450", "Q9VES5", "FBgn0038451" ] }, "reaction_10487938": { "compartment": "compartment_12045", "id": "reaction_10487938", "reactome": "R-DME-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10479146": { "compartment": "compartment_12045", "id": "reaction_10479146", "reactome": "R-DME-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10479143", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10489409": { "compartment": "compartment_12045", "id": "reaction_10489409", "reactome": "R-DME-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489403", "species_549167" ], "products": [ "species_10489407" ], "modifiers": [], "additional_components": [ "FBgn0035586", "species_1500594", "Q9VRJ2", "FBgn0035586" ] }, "reaction_10489306": { "compartment": "compartment_13977", "id": "reaction_10489306", "reactome": "R-DME-8856630", "name": "CIDEA:CIDEC binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866926", "species_10489302" ], "products": [ "species_10489304" ], "modifiers": [], "additional_components": [ "species_1500594", "species_163579", "CHEBI:16247", "A8DY77", "FBgn0028408", "Q0E9B7", "FBgn0028407", "A8DY77", "FBgn0028408", "Q0E9B7", "FBgn0028407", "species_1500594", "species_163579", "CHEBI:16247" ] }, "reaction_10489517": { "compartment": "compartment_70101", "id": "reaction_10489517", "reactome": "R-DME-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866926", "species_10478095" ], "products": [ "species_10489515" ], "modifiers": [], "additional_components": [ "species_1500594", "species_163579", "CHEBI:16247", "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043", "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043", "species_1500594", "species_163579", "CHEBI:16247" ] }, "reaction_10465087": { "compartment": "compartment_12045", "id": "reaction_10465087", "reactome": "R-DME-2161745", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2161636" ], "products": [ "species_29356", "species_29366", "species_2142740" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10465100": { "compartment": "compartment_12045", "id": "reaction_10465100", "reactome": "R-DME-2161792", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2142740" ], "products": [ "species_2161582", "species_29356", "species_29366" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10443833": { "compartment": "compartment_876", "id": "reaction_10443833", "reactome": "R-DME-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10443830", "catalyst" ] ], "additional_components": [ "FBgn0032456" ] }, "reaction_10443764": { "compartment": "compartment_876", "id": "reaction_10443764", "reactome": "R-DME-266012", "name": "LTD4 is converted to LTE4 by DPEP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266074", "species_109276" ], "products": [ "species_266029", "species_266033" ], "modifiers": [ [ "species_10443761", "catalyst" ] ], "additional_components": [ "Q9VBG1", "FBgn0039420", "X2JCU8", "FBgn0266100", "Q9VPG0", "FBgn0036986", "Q9VJ94", "FBgn0261804", "species_1562550" ] }, "reaction_10443843": { "compartment": "compartment_70101", "id": "reaction_10443843", "reactome": "R-DME-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265281" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10443825": { "compartment": "compartment_876", "id": "reaction_10443825", "reactome": "R-DME-266046", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_266013" ], "products": [ "species_266074", "species_210382" ], "modifiers": [ [ "species_10443822", "catalyst" ] ], "additional_components": [ "Q9VYR2", "FBgn0030361", "Q9VWT3", "FBgn0030932", "Q7KUX2", "FBgn0030796", "M9NFP5", "FBgn0025837" ] }, "reaction_10465110": { "compartment": "compartment_12045", "id": "reaction_10465110", "reactome": "R-DME-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10432779", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10465108": { "compartment": "compartment_12045", "id": "reaction_10465108", "reactome": "R-DME-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10432779", "catalyst" ] ], "additional_components": [ "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10465126": { "compartment": "compartment_70101", "id": "reaction_10465126", "reactome": "R-DME-2161999", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142811", "species_29450" ], "products": [ "species_29356", "species_2142678", "species_111745" ], "modifiers": [ [ "species_10465121", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10465124": { "compartment": "compartment_70101", "id": "reaction_10465124", "reactome": "R-DME-2161959", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142790" ], "products": [ "species_29356", "species_2142716", "species_111745" ], "modifiers": [ [ "species_10465121", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10478161": { "compartment": "compartment_13977", "id": "reaction_10478161", "reactome": "R-DME-5693751", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693752", "species_5693747" ], "products": [ "species_5693736", "species_5693733" ], "modifiers": [ [ "species_10478158", "catalyst" ] ], "additional_components": [ "FBgn0033717" ] }, "reaction_10464589": { "compartment": "compartment_17957", "id": "reaction_10464589", "reactome": "R-DME-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10453288", "catalyst" ] ], "additional_components": [ "Q9VV87", "FBgn0260960", "Q9VHX7", "FBgn0037534", "Q6NN18", "FBgn0034382", "Q9VCY6", "FBgn0038986", "Q9VH59", "FBgn0037761", "Q4V3H4", "FBgn0037764", "Q9VCY5", "FBgn0053110", "Q9VH58", "FBgn0037762", "A1ZBD2", "FBgn0034383", "Q9VCT3", "FBgn0039030", "Q9VH57", "FBgn0037763", "Q95T98", "FBgn0051523", "Q9VH55", "FBgn0037765", "Q8SXD1", "FBgn0050008", "Q9VCZ0", "FBgn0038983", "Q8IMY2", "FBgn0051141", "Q9VCY7", "FBgn0260942" ] }, "reaction_10464587": { "compartment": "compartment_17957", "id": "reaction_10464587", "reactome": "R-DME-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10446277", "catalyst" ] ], "additional_components": [ "FBgn0039890" ] }, "reaction_10464779": { "compartment": "compartment_17951", "id": "reaction_10464779", "reactome": "R-DME-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_2046047" ], "products": [ "species_113575", "species_2066767" ], "modifiers": [ [ "species_10446616", "catalyst" ] ], "additional_components": [ "species_113596", "Q7KML2", "FBgn0027572" ] }, "reaction_10464777": { "compartment": "compartment_17951", "id": "reaction_10464777", "reactome": "R-DME-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10464775": { "compartment": "compartment_17951", "id": "reaction_10464775", "reactome": "R-DME-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066767" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10491976": { "compartment": "compartment_70616", "id": "reaction_10491976", "reactome": "R-DME-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491965", "species_977314" ], "products": [ "species_29374", "species_10491968" ], "modifiers": [ [ "species_10491973", "catalyst" ] ], "additional_components": [ "FBgn0011361", "FBgn0011361", "FBgn0036691" ] }, "reaction_10487865": { "compartment": "compartment_17957", "id": "reaction_10487865", "reactome": "R-DME-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10487859" ], "products": [ "species_10487863" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "FBgn0031992", "Q9VLS4", "FBgn0031992", "species_164991", "species_5690542" ] }, "reaction_10477557": { "compartment": "compartment_5460", "id": "reaction_10477557", "reactome": "R-DME-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10477554", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_30495", "species_5690531", "FBgn0039854" ] }, "reaction_10477541": { "compartment": "compartment_70101", "id": "reaction_10477541", "reactome": "R-DME-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10477538", "catalyst" ] ], "additional_components": [ "species_5690542", "species_164991", "species_5690531", "species_30495", "Q9VZZ6", "FBgn0035355", "Q9VZZ5", "FBgn0035356" ] }, "reaction_10491084": { "compartment": "compartment_5460", "id": "reaction_10491084", "reactome": "R-DME-8874745", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_1524038" ], "products": [ "species_29374", "species_8874749" ], "modifiers": [ [ "species_10491081", "catalyst" ] ], "additional_components": [ "Q9VL70", "FBgn0040064" ] }, "reaction_10479074": { "compartment": "compartment_5460", "id": "reaction_10479074", "reactome": "R-DME-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_5690531" ], "products": [ "species_159448", "species_159450", "species_5690542" ], "modifiers": [ [ "species_10479071", "catalyst" ] ], "additional_components": [ "FBgn0031703" ] }, "reaction_10487885": { "compartment": "compartment_70101", "id": "reaction_10487885", "reactome": "R-DME-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164991", "species_10487881" ], "products": [ "species_10487883" ], "modifiers": [], "additional_components": [ "FBgn0064116", "Q9VRG6", "FBgn0064116", "species_164991" ] }, "reaction_10479965": { "compartment": "compartment_17951", "id": "reaction_10479965", "reactome": "R-DME-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_6787810" ], "products": [ "species_113575", "species_6787814" ], "modifiers": [ [ "species_10479962", "catalyst" ] ], "additional_components": [ "A1Z8D3", "FBgn0061356" ] }, "reaction_10486915": { "compartment": "compartment_17951", "id": "reaction_10486915", "reactome": "R-DME-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10486912", "catalyst" ] ], "additional_components": [ "FBgn0032790" ] }, "reaction_10487876": { "compartment": "compartment_17947", "id": "reaction_10487876", "reactome": "R-DME-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_10487870" ], "products": [ "species_10487874" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "FBgn0031478", "species_164991", "species_5690542", "Q9VQI6", "FBgn0031478" ] }, "reaction_10446606": { "compartment": "compartment_17951", "id": "reaction_10446606", "reactome": "R-DME-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389982", "species_192307" ], "products": [ "species_193465", "species_389996", "species_192305" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446589": { "compartment": "compartment_17951", "id": "reaction_10446589", "reactome": "R-DME-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10440153", "catalyst" ] ], "additional_components": [ "species_113596", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628" ] }, "reaction_10446637": { "compartment": "compartment_17951", "id": "reaction_10446637", "reactome": "R-DME-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353123", "species_390294" ], "products": [ "species_390287", "species_193514" ], "modifiers": [ [ "species_10446632", "catalyst" ] ], "additional_components": [ "FBgn0038486" ] }, "reaction_10446604": { "compartment": "compartment_17951", "id": "reaction_10446604", "reactome": "R-DME-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_389894" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446635": { "compartment": "compartment_17951", "id": "reaction_10446635", "reactome": "R-DME-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192314", "species_390294" ], "products": [ "species_193514", "species_390274" ], "modifiers": [ [ "species_10446632", "catalyst" ] ], "additional_components": [ "FBgn0038486" ] }, "reaction_10446601": { "compartment": "compartment_17951", "id": "reaction_10446601", "reactome": "R-DME-389897", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389569" ], "products": [ "species_389893" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10446599": { "compartment": "compartment_17951", "id": "reaction_10446599", "reactome": "R-DME-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10446596", "catalyst" ] ], "additional_components": [ "species_113596", "B7Z028", "FBgn0031813" ] }, "reaction_10446627": { "compartment": "compartment_17951", "id": "reaction_10446627", "reactome": "R-DME-390281", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390271", "species_390294" ], "products": [ "species_193514", "species_390290" ], "modifiers": [ [ "species_10446624", "catalyst" ] ], "additional_components": [ "FBgn0039543" ] }, "reaction_10446619": { "compartment": "compartment_17951", "id": "reaction_10446619", "reactome": "R-DME-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10446616", "catalyst" ] ], "additional_components": [ "species_113596", "Q7KML2", "FBgn0027572" ] }, "reaction_10446647": { "compartment": "compartment_17947", "id": "reaction_10446647", "reactome": "R-DME-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10446279", "catalyst" ] ], "additional_components": [ "Q7JUN3", "FBgn0039890" ] }, "reaction_10446610": { "compartment": "compartment_17951", "id": "reaction_10446610", "reactome": "R-DME-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446608": { "compartment": "compartment_17951", "id": "reaction_10446608", "reactome": "R-DME-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446474": { "compartment": "compartment_17951", "id": "reaction_10446474", "reactome": "R-DME-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10446471", "catalyst" ] ], "additional_components": [ "species_8878387", "species_29926", "Q7K3B7", "FBgn0034488" ] }, "reaction_10446488": { "compartment": "compartment_17951", "id": "reaction_10446488", "reactome": "R-DME-389632", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6811612", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389569", "species_389620" ], "modifiers": [ [ "species_10446482", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10446485": { "compartment": "compartment_17951", "id": "reaction_10446485", "reactome": "R-DME-389622", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389596", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389615", "species_389620" ], "modifiers": [ [ "species_10446482", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10446496": { "compartment": "compartment_17947", "id": "reaction_10446496", "reactome": "R-DME-389652", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_389620" ], "products": [ "species_389573", "species_76577" ], "modifiers": [ [ "species_10446493", "catalyst" ] ], "additional_components": [ "FBgn0052250" ] }, "reaction_10484754": { "compartment": "compartment_70101", "id": "reaction_10484754", "reactome": "R-DME-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10484748", "catalyst" ] ], "additional_components": [ "Q9VP65", "FBgn0037061", "Q9VQF8", "FBgn0031454" ] }, "reaction_10479105": { "compartment": "compartment_70101", "id": "reaction_10479105", "reactome": "R-DME-5696230", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5696214" ], "products": [ "species_29356", "species_5696224", "species_111745" ], "modifiers": [ [ "species_10438462", "catalyst" ] ], "additional_components": [ "Q9VSL3", "FBgn0086348" ] }, "reaction_10438713": { "compartment": "compartment_70101", "id": "reaction_10438713", "reactome": "R-DME-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10438710", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438678": { "compartment": "compartment_70101", "id": "reaction_10438678", "reactome": "R-DME-176521", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_158471" ], "products": [ "species_176492", "species_158466" ], "modifiers": [ [ "species_10438632", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438708": { "compartment": "compartment_70101", "id": "reaction_10438708", "reactome": "R-DME-176609", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_158471" ], "products": [ "species_176618", "species_158466" ], "modifiers": [ [ "species_10438667", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438675": { "compartment": "compartment_70101", "id": "reaction_10438675", "reactome": "R-DME-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_158471" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10438672", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438738": { "compartment": "compartment_70101", "id": "reaction_10438738", "reactome": "R-DME-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10438735", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438706": { "compartment": "compartment_70101", "id": "reaction_10438706", "reactome": "R-DME-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_29372", "species_76577" ], "modifiers": [ [ "species_10438703", "catalyst" ] ], "additional_components": [ "FBgn0039698" ] }, "reaction_10435664": { "compartment": "compartment_70101", "id": "reaction_10435664", "reactome": "R-DME-158860", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158847", "species_158471" ], "products": [ "species_158859", "species_158466" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10435662": { "compartment": "compartment_70101", "id": "reaction_10435662", "reactome": "R-DME-158849", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158858", "species_158471" ], "products": [ "species_158466", "species_158850" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438670": { "compartment": "compartment_70101", "id": "reaction_10438670", "reactome": "R-DME-176494", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176617", "species_158471" ], "products": [ "species_176502", "species_158466" ], "modifiers": [ [ "species_10438667", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438733": { "compartment": "compartment_70101", "id": "reaction_10438733", "reactome": "R-DME-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176575", "species_158471" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10438730", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10494994": { "compartment": "compartment_17963", "id": "reaction_10494994", "reactome": "R-DME-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10494991", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_29926", "Q9VYF2", "FBgn0030465" ] }, "reaction_10438698": { "compartment": "compartment_70101", "id": "reaction_10438698", "reactome": "R-DME-176604", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176565", "species_158471" ], "products": [ "species_176483", "species_158466" ], "modifiers": [ [ "species_10438642", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438728": { "compartment": "compartment_70101", "id": "reaction_10438728", "reactome": "R-DME-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695950", "species_158471" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10438725", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438696": { "compartment": "compartment_70101", "id": "reaction_10438696", "reactome": "R-DME-176588", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_158471" ], "products": [ "species_176555", "species_158466" ], "modifiers": [ [ "species_10438642", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438693": { "compartment": "compartment_70101", "id": "reaction_10438693", "reactome": "R-DME-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176667", "species_158471" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10438690", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10435652": { "compartment": "compartment_70101", "id": "reaction_10435652", "reactome": "R-DME-158468", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158469", "species_158471" ], "products": [ "species_158472", "species_158466" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10435745": { "compartment": "compartment_70101", "id": "reaction_10435745", "reactome": "R-DME-159358", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_159362" ], "products": [ "species_159352", "species_158466" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438657": { "compartment": "compartment_70101", "id": "reaction_10438657", "reactome": "R-DME-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10438654", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438525": { "compartment": "compartment_70101", "id": "reaction_10438525", "reactome": "R-DME-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10438522", "catalyst" ] ], "additional_components": [ "CHEBI:29132", "CHEBI:34718", "CHEBI:30614", "CHEBI:8927", "CHEBI:32639", "CHEBI:34479", "A1Z7X7", "FBgn0050005", "Q8MRM0", "FBgn0030484", "Q7K0B6", "FBgn0050000", "E1JJS1", "FBgn0031117", "Q9VSL3", "FBgn0086348", "P41043", "FBgn0010226", "Q9VSL6", "FBgn0035907", "Q9VSL5", "FBgn0035906", "Q9VSL2", "FBgn0035904", "Q9VHD2", "FBgn0037697" ] }, "reaction_10438399": { "compartment": "compartment_70101", "id": "reaction_10438399", "reactome": "R-DME-174367", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111707", "species_113592" ], "products": [ "species_29372", "species_174393", "species_29370" ], "modifiers": [ [ "species_10438396", "catalyst" ] ], "additional_components": [ "Q9VCW6", "FBgn0046114", "Q9W3K5", "FBgn0040319" ] }, "reaction_10458317": { "compartment": "compartment_70101", "id": "reaction_10458317", "reactome": "R-DME-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1247942" ], "products": [ "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10458314", "catalyst" ] ], "additional_components": [ "Q9W247", "FBgn0034733" ] }, "reaction_10493315": { "compartment": "compartment_876", "id": "reaction_10493315", "reactome": "R-DME-8943279", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1247892" ], "products": [ "species_210382", "species_1247934" ], "modifiers": [ [ "species_10472545", "catalyst" ] ], "additional_components": [ "Q7KUX2", "FBgn0030796", "M9NFP5", "FBgn0025837", "Q9VYR2", "FBgn0030361", "Q9VWT3", "FBgn0030932" ] }, "reaction_10458297": { "compartment": "compartment_70101", "id": "reaction_10458297", "reactome": "R-DME-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1247904" ], "products": [ "species_111707", "species_29424" ], "modifiers": [ [ "species_10458294", "catalyst" ] ], "additional_components": [ "species_266099", "Q8MT58", "FBgn0259979" ] }, "reaction_10479737": { "compartment": "compartment_70101", "id": "reaction_10479737", "reactome": "R-DME-6785928", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450" ], "products": [ "species_1247942", "species_1247904" ], "modifiers": [ [ "species_10479732", "catalyst" ] ], "additional_components": [ "FBgn0030411" ] }, "reaction_10458307": { "compartment": "compartment_70101", "id": "reaction_10458307", "reactome": "R-DME-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10458304", "catalyst" ] ], "additional_components": [ "Q8IQT0", "FBgn0052196" ] }, "reaction_10478153": { "compartment": "compartment_17957", "id": "reaction_10478153", "reactome": "R-DME-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10478150", "catalyst" ] ], "additional_components": [ "Q7KSB5", "FBgn0038771" ] }, "reaction_10477976": { "compartment": "compartment_70101", "id": "reaction_10477976", "reactome": "R-DME-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10475407", "catalyst" ] ], "additional_components": [ "FBgn0035476" ] }, "reaction_10438535": { "compartment": "compartment_17957", "id": "reaction_10438535", "reactome": "R-DME-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10438532", "catalyst" ] ], "additional_components": [ "CHEBI:30725", "CHEBI:27561", "CHEBI:29132", "CHEBI:32639", "CHEBI:2505", "CHEBI:35896", "Q8SY19", "FBgn0025814" ] }, "reaction_10478143": { "compartment": "compartment_17957", "id": "reaction_10478143", "reactome": "R-DME-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10478140", "catalyst" ] ], "additional_components": [ "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943", "A1ZA97", "FBgn0034076" ] }, "reaction_10479631": { "compartment": "compartment_70101", "id": "reaction_10479631", "reactome": "R-DME-6784959", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6784964" ], "products": [ "species_29702", "species_561052" ], "modifiers": [ [ "species_10479628", "catalyst" ] ], "additional_components": [ "FBgn0038974" ] }, "reaction_10478233": { "compartment": "compartment_12045", "id": "reaction_10478233", "reactome": "R-DME-5694077", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694080" ], "products": [ "species_5694091" ], "modifiers": [ [ "species_10478230", "catalyst" ] ], "additional_components": [ "FBgn0034405" ] }, "reaction_10429084": { "compartment": "compartment_70101", "id": "reaction_10429084", "reactome": "R-DME-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10429081", "catalyst" ] ], "additional_components": [ "P46415", "FBgn0011768", "species_1562550" ] }, "reaction_10429112": { "compartment": "compartment_70101", "id": "reaction_10429112", "reactome": "R-DME-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29416", "species_76194" ], "products": [ "species_111294", "species_76183", "species_76577" ], "modifiers": [ [ "species_10429109", "catalyst" ] ], "additional_components": [ "FBgn0012034" ] }, "reaction_10429094": { "compartment": "compartment_5460", "id": "reaction_10429094", "reactome": "R-DME-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10429091", "catalyst" ] ], "additional_components": [ "Q9VLC5", "FBgn0012036" ] }, "reaction_10479094": { "compartment": "compartment_5460", "id": "reaction_10479094", "reactome": "R-DME-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10429091", "catalyst" ] ], "additional_components": [ "Q9VLC5", "FBgn0012036" ] }, "reaction_10477985": { "compartment": "compartment_70101", "id": "reaction_10477985", "reactome": "R-DME-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10477982", "catalyst" ] ], "additional_components": [ "species_1562550", "P46415", "FBgn0011768" ] }, "reaction_10492075": { "compartment": "compartment_70101", "id": "reaction_10492075", "reactome": "R-DME-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_8936443", "species_73473" ], "products": [ "species_29356", "species_29468", "species_29360" ], "modifiers": [ [ "species_10492072", "catalyst" ] ], "additional_components": [ "A1Z803", "FBgn0033451", "CHEBI:21437", "X2JGK6", "FBgn0036211", "Q9V4N3", "FBgn0264294" ] }, "reaction_10492235": { "compartment": "compartment_70101", "id": "reaction_10492235", "reactome": "R-DME-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10492232", "catalyst" ] ], "additional_components": [ "P23654", "FBgn0004108", "Q8T016", "FBgn0033943", "Q9VLA3", "FBgn0032132", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076" ] }, "reaction_10465054": { "compartment": "compartment_70101", "id": "reaction_10465054", "reactome": "R-DME-2161500", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161525" ], "products": [ "species_2161185" ], "modifiers": [ [ "species_10465051", "catalyst" ] ], "additional_components": [ "Q7K3M6", "FBgn0034479", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10455658": { "compartment": "compartment_876", "id": "reaction_10455658", "reactome": "R-DME-975340", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10455655", "catalyst" ] ], "additional_components": [ "species_352011", "Q8SWZ1", "FBgn0033558", "Q08832", "FBgn0010240", "P25123", "FBgn0004244", "Q9VXL9", "FBgn0030707", "Q24352", "FBgn0001134", "Q9W0S2", "FBgn0264707" ] }, "reaction_10455765": { "compartment": "compartment_876", "id": "reaction_10455765", "reactome": "R-DME-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10455762", "catalyst" ] ], "additional_components": [ "species_352011", "Q8SWZ1", "FBgn0033558", "Q08832", "FBgn0010240", "P25123", "FBgn0004244" ] }, "reaction_10435001": { "compartment": "compartment_70101", "id": "reaction_10435001", "reactome": "R-DME-114683", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434995", "species_113592" ], "products": [ "species_29370", "species_10434998" ], "modifiers": [ [ "species_10434975", "catalyst" ] ], "additional_components": [ "FBgn0004574", "FBgn0004574", "species_114519", "species_33625", "species_74016", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10452783": { "compartment": "compartment_876", "id": "reaction_10452783", "reactome": "R-DME-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452699" ], "products": [ "species_10452781" ], "modifiers": [], "additional_components": [ "species_29438", "Q9VH14", "FBgn0025879", "species_29370", "species_29926", "Q9VN93", "FBgn0260462", "Q9VKY4", "FBgn0032228", "species_113592", "species_29372", "Q24276", "FBgn0011573", "species_74016", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q7K187", "FBgn0030330", "species_114523", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "species_29420", "species_113541", "species_74016", "species_29438", "Q9VH14", "FBgn0025879", "species_29370", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "species_113541", "species_29926", "species_113592", "Q7K187", "FBgn0030330", "Q9VN93", "FBgn0260462", "Q9VKY4", "FBgn0032228", "species_114523", "species_29372", "Q24276", "FBgn0011573", "species_29420", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10452814": { "compartment": "compartment_876", "id": "reaction_10452814", "reactome": "R-DME-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452802" ], "products": [ "species_10452812" ], "modifiers": [], "additional_components": [ "B7YZX0", "FBgn0032797", "Q9VLH1", "FBgn0032074", "Q9V9S0", "FBgn0032949", "O76901", "FBgn0025382", "O76901", "FBgn0025382", "B7YZX0", "FBgn0032797", "Q9VLH1", "FBgn0032074", "Q9V9S0", "FBgn0032949" ] }, "reaction_10444110": { "compartment": "compartment_161320", "id": "reaction_10444110", "reactome": "R-DME-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444102" ], "products": [ "species_10444108" ], "modifiers": [], "additional_components": [ "Q9Y125", "FBgn0000416", "Q9VLS0", "FBgn0031996", "Q9Y125", "FBgn0000416", "Q9VLS0", "FBgn0031996" ] }, "reaction_10452605": { "compartment": "compartment_876", "id": "reaction_10452605", "reactome": "R-DME-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452245" ], "products": [ "species_10452603" ], "modifiers": [], "additional_components": [ "Q7JQR3", "FBgn0033814", "Q9VLU2", "FBgn0031975", "Q9VK28", "FBgn0032479", "Q8SXT3", "FBgn0034262", "Q9VK22", "FBgn0032484", "Q9VKG1", "FBgn0015400", "D0IQL1", "FBgn0034540", "Q9VJN8", "FBgn0028518", "Q9VK54", "FBgn0015399", "A0A4D6K327", "FBgn0261509", "Q9V430", "FBgn0028370", "O97365", "FBgn0026562", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "O77277", "FBgn0025615", "Q9VX97", "FBgn0030803", "A1Z9D7", "FBgn0000119", "P18091", "FBgn0000667", "Q9VWP6", "FBgn0030964", "Q9I7L4", "FBgn0037481", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q7K1H0", "FBgn0052066", "Q8SWU7", "FBgn0030151", "P14599", "FBgn0000108", "Q960F7", "FBgn0037391", "Q9VU94", "FBgn0029167", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P07713", "FBgn0000490", "Q9VN86", "FBgn0037298", "Q9W5T4", "FBgn0250830", "Q9VM97", "FBgn0031850", "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688", "Q9W0A0", "FBgn0027594", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9VEY5", "FBgn0038400", "Q9VH14", "FBgn0025879", "D0IQL1", "FBgn0034540", "A0A4D6K327", "FBgn0261509", "Q9VKG1", "FBgn0015400", "Q9VK54", "FBgn0015399", "Q9VK28", "FBgn0032479", "Q9VK22", "FBgn0032484", "Q9VJN8", "FBgn0028518", "Q9V430", "FBgn0028370", "Q8SXT3", "FBgn0034262", "Q7JQR3", "FBgn0033814", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "O97365", "FBgn0026562", "P07713", "FBgn0000490", "Q9W0A0", "FBgn0027594", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9VH14", "FBgn0025879", "Q9VLU2", "FBgn0031975", "P18091", "FBgn0000667", "Q9VM97", "FBgn0031850", "A1Z9D7", "FBgn0000119", "Q9VN86", "FBgn0037298", "Q9VWP6", "FBgn0030964", "Q9W5T4", "FBgn0250830", "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VX97", "FBgn0030803", "O77277", "FBgn0025615", "Q9VU94", "FBgn0029167", "P14599", "FBgn0000108", "Q9I7L4", "FBgn0037481", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q7K1H0", "FBgn0052066", "Q8SWU7", "FBgn0030151", "Q960F7", "FBgn0037391", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q9VEY5", "FBgn0038400" ] }, "reaction_10453019": { "compartment": "compartment_70101", "id": "reaction_10453019", "reactome": "R-DME-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452947" ], "products": [ "species_10453017" ], "modifiers": [], "additional_components": [ "Q07327", "FBgn0004574", "Q7JVP4", "FBgn0033155", "P61851", "FBgn0003462", "Q9VSL8", "FBgn0260442", "Q9VU68", "FBgn0260049", "Q9XZ63", "FBgn0027095", "O46037", "FBgn0004397", "Q9VZI1", "FBgn0035499", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "Q9VEN1", "FBgn0014141", "Q9V426", "FBgn0024183", "D2A6L8", "FBgn0265047", "Q9VED6", "FBgn0038565", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q7JVP4", "FBgn0033155", "P61851", "FBgn0003462", "Q9XZ63", "FBgn0027095", "Q9VED6", "FBgn0038565", "Q9VU68", "FBgn0260049", "Q9VZI1", "FBgn0035499", "O46037", "FBgn0004397", "Q07327", "FBgn0004574", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q9VSL8", "FBgn0260442", "Q9VEN1", "FBgn0014141", "Q9V426", "FBgn0024183", "D2A6L8", "FBgn0265047", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743" ] }, "reaction_10452903": { "compartment": "compartment_984", "id": "reaction_10452903", "reactome": "R-DME-482770", "name": "Release of platelet secretory granule components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452899" ], "products": [ "species_10452901" ], "modifiers": [], "additional_components": [ "FBgn0022355", "FBgn0022355" ] }, "reaction_10452882": { "compartment": "compartment_876", "id": "reaction_10452882", "reactome": "R-DME-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452858" ], "products": [ "species_10452880" ], "modifiers": [], "additional_components": [ "Q961B9", "FBgn0036579", "Q9VZN0", "FBgn0052264", "P14599", "FBgn0000108", "Q9W0X9", "FBgn0035085", "B7YZX0", "FBgn0032797", "Q9VID1", "FBgn0032943", "Q9VFH5", "FBgn0038247", "Q9VGG5", "FBgn0037963", "Q9NFV7", "FBgn0041182", "X2JGK6", "FBgn0036211", "E1JI63", "FBgn0035815", "P14599", "FBgn0000108", "Q9W0X9", "FBgn0035085", "Q9VID1", "FBgn0032943", "Q9NFV7", "FBgn0041182", "E1JI63", "FBgn0035815", "X2JGK6", "FBgn0036211", "B7YZX0", "FBgn0032797", "Q961B9", "FBgn0036579", "Q9VZN0", "FBgn0052264", "Q9VGG5", "FBgn0037963", "Q9VFH5", "FBgn0038247" ] }, "reaction_10448864": { "compartment": "compartment_114584", "id": "reaction_10448864", "reactome": "R-DME-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_114565" ], "modifiers": [ [ "species_10448861", "catalyst" ] ], "additional_components": [ "FBgn0032026" ] }, "reaction_10434977": { "compartment": "compartment_70101", "id": "reaction_10434977", "reactome": "R-DME-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_74016", "species_10434959" ], "products": [ "species_10434975" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "P13677", "FBgn0004784", "P05130", "FBgn0003091", "species_114519", "species_33625", "species_74016", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10457707": { "compartment": "compartment_70101", "id": "reaction_10457707", "reactome": "R-DME-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457703" ], "products": [ "species_10457705" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10443664": { "compartment": "compartment_984", "id": "reaction_10443664", "reactome": "R-DME-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10443660" ], "products": [ "species_10443662" ], "modifiers": [], "additional_components": [ "Q9VRC9", "FBgn0261675", "Q9VL24", "FBgn0024320", "Q9VRC9", "FBgn0261675", "Q9VL24", "FBgn0024320", "species_265479" ] }, "reaction_10439533": { "compartment": "compartment_876", "id": "reaction_10439533", "reactome": "R-DME-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10439530", "catalyst" ] ], "additional_components": [ "FBgn0264574" ] }, "reaction_10439540": { "compartment": "compartment_876", "id": "reaction_10439540", "reactome": "R-DME-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10439537", "catalyst" ] ], "additional_components": [ "species_964746", "species_188995", "species_29532", "species_188995", "species_964746", "species_29532", "Q8IRI6", "FBgn0264574" ] }, "reaction_209376": { "compartment": "compartment_984", "id": "reaction_209376", "reactome": "R-DME-209376", "name": "SPN27A binds to and inhibits EA protease activity", "reversible": "false", "notes": "In dorsoventral patterning, the serpin SPN27A binds to Easter (EA) serine protease. This complex inhibits Spatzle (SPZ) dimer processing.", "reactants": [ "species_205912", "species_206231" ], "products": [ "species_206652" ], "modifiers": [], "additional_components": [ "Q9V3N1", "Spn27A", "P13582", "ProEA" ] }, "reaction_209141": { "compartment": "compartment_984", "id": "reaction_209141", "reactome": "R-DME-209141", "name": "ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane", "reversible": "false", "notes": "On binding to the Toll (TL) receptor ectodomain, Spatzle (SPZ) dimer sheds its Pro-domains. The SPZ dimer binds to the TL ectodomain at its N-terminus.", "reactants": [ "species_206793", "species_206218" ], "products": [ "species_205949", "species_206655" ], "modifiers": [], "additional_components": [ "P48607", "ProSPZ", "P08953", "TL", "P48607", "ProSPZ" ] }, "reaction_209076": { "compartment": "compartment_876", "id": "reaction_209076", "reactome": "R-DME-209076", "name": "SPZ dimer bound TL dimerises at the plasma membrane", "reversible": "false", "notes": "The binding of a Spatzle (SPZ) dimer to the N-terminus of the Toll (TL) receptor ectodomain triggers a conformational change in TL. This results in two discrete regions of the TL receptor ectodomains, one near the N-terminus and the other in the juxtamembrane region, to interact, inducing dimerisation and forming a 2:2 complex. The transmembrane segments of the receptor chains will be forced into close proximity forming additional favourable interactions which stabilise the dimer.", "reactants": [ "species_206655" ], "products": [ "species_206637" ], "modifiers": [], "additional_components": [ "P08953", "TL", "P48607", "ProSPZ", "P08953", "TL", "P48607", "ProSPZ" ] }, "reaction_209156": { "compartment": "compartment_70101", "id": "reaction_209156", "reactome": "R-DME-209156", "name": "MYD88 binds to TUB", "reversible": "false", "notes": "In close proximity to the plasma membrane, the adaptor proteins MYD88 and Tube (TUB) bind together through their death domains.", "reactants": [ "species_206015", "species_206155" ], "products": [ "species_206621" ], "modifiers": [], "additional_components": [ "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214891": { "compartment": "compartment_984", "id": "reaction_214891", "reactome": "R-DME-214891", "name": "Full-length GD is cleaved by an unknown protease", "reversible": "false", "notes": "During early embryonic patterning, Toll (TL) is required for establishing the dorsoventral axis. The TL signal is initiated by activation of its ligand Spatzle (SPZ) by a serine protease cascade. Activation of this cascade is regulated by the probable chaperone protein Windbeutel (WBL) and by Pipe (PIP), a heparan-sulphanotransferase that has been proposed to create a heparin-modified proteoglycan that is required for local activation of the cascade. PIP is the only dorsoventral factor to be expressed on the ventral side of the embryo and is thought to be the key in activating the cascade. The full-length serine protease zymogen, Gastrulation Defective (GD) is cleaved between Arg136 and Lys137. This separates the inhibitory prodomain from the now active mature enzyme. How GD is activated remains uncertain, although a direct interaction with Nudel (NDL) or autoproteolytic processing cannot be ruled out.", "reactants": [ "species_214753" ], "products": [ "species_214276", "species_214754" ], "modifiers": [ [ "species_214274", "catalyst" ] ], "additional_components": [] }, "reaction_209130": { "compartment": "compartment_984", "id": "reaction_209130", "reactome": "R-DME-209130", "name": "Full-length SPZ dimer is cleaved by EA/SPE serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the trypsin-like serine protease Easter (EA) is known to cleave full-length Spatzle (SPZ) dimer between residues Arg220 and Val221. This frees the Pro-domain and the C-terminal SPZ dimer aka C-106. In the innate immunity response, the serine protease cleavage enzyme is the Spatzle-processing enzyme aka SPE (CG16705). The Pro-domains and the SPZ dimer remain associated after cleavage.", "reactants": [ "species_206598" ], "products": [ "species_206793" ], "modifiers": [ [ "species_206576", "catalyst" ] ], "additional_components": [ "P48607", "ProSPZ", "P48607", "ProSPZ", "Q9VCJ8", "SPE", "P13582", "ProEA" ] }, "reaction_214953": { "compartment": "compartment_984", "id": "reaction_214953", "reactome": "R-DME-214953", "name": "Full-length SNK is cleaved by GD serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the full-length serine protease zymogen, Snake (SNK), is cleaved by active Gastrulation Defective (GD) serine protease between residues Leu185 and Ile186. The removal of the prodomain results in an active SNK protease.", "reactants": [ "species_214747" ], "products": [ "species_214750", "species_214280" ], "modifiers": [ [ "species_214276", "catalyst" ] ], "additional_components": [] }, "reaction_214853": { "compartment": "compartment_70101", "id": "reaction_214853", "reactome": "R-DME-214853", "name": "WEK and MYD88:TUB bind to the TL receptor", "reversible": "false", "notes": "Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homodimerisation and activation. In dorsoventral patterning in Drosophila embryos, the zinc finger containing adaptor protein Weckle, (WEK) binds to both the TL receptor cytoplasmic domain and the adaptor protein MYD88, which in complex with Tube (TUB), also binds to TL. In addition, WEK forms dimers through its N-terminal region.", "reactants": [ "species_206621", "species_206637", "species_214745" ], "products": [ "species_214743" ], "modifiers": [], "additional_components": [ "P22812", "TUB", "Q7K105", "MYD88", "P08953", "TL", "P48607", "ProSPZ", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_209100": { "compartment": "compartment_70101", "id": "reaction_209100", "reactome": "R-DME-209100", "name": "MYD88:TUB binds to TL receptor", "reversible": "false", "notes": "Upon Spatzle (SPZ) dimer binding, leading to Toll (TL) receptor homodimerisation and activation, MYD88:TUB complex binds to the endoplasmic Toll/Interleukin-1 receptor (TIR) domain of TL receptor at the plasma membrane.", "reactants": [ "species_206621", "species_206637" ], "products": [ "species_206600" ], "modifiers": [], "additional_components": [ "P22812", "TUB", "Q7K105", "MYD88", "P08953", "TL", "P48607", "ProSPZ", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214956": { "compartment": "compartment_984", "id": "reaction_214956", "reactome": "R-DME-214956", "name": "Full-length EA is cleaved by SNK serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the full-length serine protease zymogen, Easter (EA) is cleaved by active serine protease, Snake (SNK), between residues Arg127 and Ile128. The removal of the inhibitory prodomain results in an active EA serine protease.", "reactants": [ "species_214751" ], "products": [ "species_205912", "species_214755" ], "modifiers": [ [ "species_214280", "catalyst" ] ], "additional_components": [] }, "reaction_214871": { "compartment": "compartment_70101", "id": "reaction_214871", "reactome": "R-DME-214871", "name": "Phosphorylated CACT is degraded in the cytosol", "reversible": "false", "notes": "In humans, the Cactus (CACT) orthologue IkappaB is polyubiquitinated by the beta-TrCP E3 ubiquitin ligase containing complex. This marks it for degradation by the 26S proteosome. It is believed that CACT is degraded in a similar manner, however, a Drosophila E3 ubiquitin ligase that acts in the Toll pathway has yet to be identified. The obvious candidate, the closest beta-TrCP orthologue Slimb (SLMB) has produced contradictory evidence on whether it participates in the Toll pathway (Spencer et al., 1999; Leulier et al., 2003).", "reactants": [ "species_214741" ], "products": [ "species_214728" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P15330", "dl", "P98149", "Dif", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_214864": { "compartment": "compartment_70101", "id": "reaction_214864", "reactome": "R-DME-214864", "name": "Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Once phosphorylated, Cactus (CACT), in complex with the Dorsal/Dorsal-related immunity factor (DL/DIF) homodimer, dissociates from the Toll (TL) receptor 'signalling complex'.", "reactants": [ "species_214748" ], "products": [ "species_214741", "species_206693" ], "modifiers": [], "additional_components": [ "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL" ] }, "reaction_214847": { "compartment": "compartment_70101", "id": "reaction_214847", "reactome": "R-DME-214847", "name": "Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Once phosphorylated, Cactus (CACT), in complex with the Dorsal (DL) homodimer, dissociates from the Toll (TL) receptor 'signalling complex'.", "reactants": [ "species_214749" ], "products": [ "species_214759", "species_214752" ], "modifiers": [], "additional_components": [ "P15330", "dl", "Q03017", "phospho-cact", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "P15330", "dl", "Q03017", "phospho-cact" ] }, "reaction_209057": { "compartment": "compartment_70101", "id": "reaction_209057", "reactome": "R-DME-209057", "name": "Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "On binding to the 'signalling complex', the Ser/Thr kinase Pelle (PLL) is activated and autophosphorylates.", "reactants": [ "species_206889", "species_113592" ], "products": [ "species_29370", "species_206693" ], "modifiers": [ [ "species_206889", "catalyst" ] ], "additional_components": [ "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214859": { "compartment": "compartment_70101", "id": "reaction_214859", "reactome": "R-DME-214859", "name": "Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "On binding to the 'signalling complex', the Ser/Thr kinase Pelle (PLL) is activated and autophosphorylates.", "reactants": [ "species_113592", "species_214742" ], "products": [ "species_29370", "species_214759" ], "modifiers": [ [ "species_214742", "catalyst" ] ], "additional_components": [ "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214845": { "compartment": "compartment_70101", "id": "reaction_214845", "reactome": "R-DME-214845", "name": "CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Pelle (PLL) may be the kinase that phosphorylates both Cactus (CACT) and the Dorsal (DL) homodimer but the biochemical evidence for this is currently inconclusive. CACT is phosphorylated in its N-terminal half within the first 125 residues. In this region, there are two IKK target-like motifs, involving Ser74 and Ser78 in one, and Ser116 in the other. However, it is not clear which of these residues need to be phosphorylated. DL homodimer is phosphorylated at both Ser317 residues while associated with CACT.", "reactants": [ "species_113592", "species_214758" ], "products": [ "species_214749", "species_29370" ], "modifiers": [ [ "species_206306", "catalyst" ] ], "additional_components": [ "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P15330", "dl", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "P15330", "dl", "Q03017", "phospho-cact", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214860": { "compartment": "compartment_70101", "id": "reaction_214860", "reactome": "R-DME-214860", "name": "CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Pelle (PLL) may be the kinase that phosphorylates both Cactus (CACT) and the Dorsal/Dorsal-related immunity factor (DL/DIF) homodimer but the biochemical evidence for this is currently inconclusive. DL/DIF homodimer is phosphorylated while associated with CACT. DL is phosphorylated on Ser317 while DIF is very likely to be phosphorylated at Ser348 (inferred from DL). CACT is phosphorylated in its N-terminal half within the first 125 residues. In this region, there are two IKK target-like motifs, involving Ser74 and Ser78 in one, and Ser116 in the other. However, it is not clear which of these residues need to be phosphorylated.", "reactants": [ "species_214744", "species_113592" ], "products": [ "species_214748", "species_29370" ], "modifiers": [ [ "species_206306", "catalyst" ] ], "additional_components": [ "P08953", "TL", "P48607", "ProSPZ", "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL" ] }, "reaction_10466911": { "compartment": "compartment_876", "id": "reaction_10466911", "reactome": "R-DME-2730862", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466905" ], "products": [ "species_29370", "species_10466908" ], "modifiers": [ [ "species_10466905", "catalyst" ] ], "additional_components": [ "FBgn0262733", "FBgn0262733", "FBgn0262733" ] }, "reaction_10441884": { "compartment": "compartment_70101", "id": "reaction_10441884", "reactome": "R-DME-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441880", "species_202277" ], "products": [ "species_10441882" ], "modifiers": [], "additional_components": [ "species_202247", "species_179838", "species_202247", "species_179838", "Q9W0V1", "Pdk1" ] }, "reaction_10466859": { "compartment": "compartment_876", "id": "reaction_10466859", "reactome": "R-DME-2730842", "name": "PI3K associates with phosphorylated GAB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466855", "species_10431820" ], "products": [ "species_10466857" ], "modifiers": [], "additional_components": [ "Q9VZZ9", "FBgn0016794", "species_179838", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VZZ9", "FBgn0016794", "species_179838", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466946": { "compartment": "compartment_876", "id": "reaction_10466946", "reactome": "R-DME-2730870", "name": "Phosphorylation of PIP2 to PIP3 by PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10466857", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VZZ9", "FBgn0016794", "species_179838", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466861": { "compartment": "compartment_70101", "id": "reaction_10466861", "reactome": "R-DME-2730844", "name": "Interaction of GRB2:SOS complex with p-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10465768" ], "products": [ "species_10465770" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466844": { "compartment": "compartment_876", "id": "reaction_10466844", "reactome": "R-DME-2730841", "name": "Phosphorylation and activation of VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466842" ], "products": [ "species_10466835", "species_29370" ], "modifiers": [ [ "species_179838", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466840": { "compartment": "compartment_70101", "id": "reaction_10466840", "reactome": "R-DME-2730840", "name": "Activation of RAC1 by VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10466835", "species_428485" ], "products": [ "species_29420", "species_10466837" ], "modifiers": [ [ "species_10466835", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "P40792", "RAC1_DROME", "species_29420", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466952": { "compartment": "compartment_876", "id": "reaction_10466952", "reactome": "R-DME-2730889", "name": "Recruitment of PAK to the membrane by binding active RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466884", "species_10466837" ], "products": [ "species_10466886" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10466903": { "compartment": "compartment_876", "id": "reaction_10466903", "reactome": "R-DME-2730858", "name": "Autophosphorylation of BTK/ITK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466826" ], "products": [ "species_10466900", "species_29370" ], "modifiers": [ [ "species_10466826", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "species_179838", "P08630", "FBgn0003502", "P08630", "FBgn0003502", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "species_179838", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "species_179838", "P08630", "FBgn0003502" ] }, "reaction_10466871": { "compartment": "compartment_70101", "id": "reaction_10466871", "reactome": "R-DME-2730847", "name": "Hydrolysis of PIP2 by PLCG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10466868", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "species_179838", "P08630", "FBgn0003502", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VXH3", "FBgn0003416" ] }, "reaction_10477775": { "compartment": "compartment_70101", "id": "reaction_10477775", "reactome": "R-DME-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477766" ], "products": [ "species_10477770", "species_10477772" ], "modifiers": [ [ "species_10477766", "catalyst" ] ], "additional_components": [ "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725", "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725", "FBgn0032725", "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725" ] }, "reaction_10475484": { "compartment": "compartment_70101", "id": "reaction_10475484", "reactome": "R-DME-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475473", "species_10475480" ], "products": [ "species_10475482" ], "modifiers": [], "additional_components": [ "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q9XZ61", "Uch-L5" ] }, "reaction_10477752": { "compartment": "compartment_7660", "id": "reaction_10477752", "reactome": "R-DME-5690785", "name": "BAP1 binds Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477180", "species_10477741" ], "products": [ "species_10477743" ], "modifiers": [], "additional_components": [ "FBgn0262166", "FBgn0039904", "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166" ] }, "reaction_10477720": { "compartment": "compartment_70101", "id": "reaction_10477720", "reactome": "R-DME-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477715" ], "products": [ "species_1131871", "species_10477717" ], "modifiers": [ [ "species_10477715", "catalyst" ] ], "additional_components": [ "P35122", "FBgn0010288", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P35122", "FBgn0010288", "P35122", "FBgn0010288", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10477175": { "compartment": "compartment_7660", "id": "reaction_10477175", "reactome": "R-DME-5689544", "name": "UCHL5 binds INO80 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477169", "species_10477171" ], "products": [ "species_10477173" ], "modifiers": [], "additional_components": [ "Q7K012", "FBgn0025716", "Q9Y0Z1", "FBgn0027503", "Q8ST83", "FBgn0002521", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "Q9W3D4", "FBgn0040929", "Q9VH07", "FBgn0040078", "A1Z6E8", "FBgn0033019", "A1Z8D5", "FBgn0033566", "Q9VX09", "FBgn0030877", "Q9VFH4", "FBgn0086686", "Q9VEC3", "FBgn0038576", "Q4V604", "FBgn0052202", "Q9VDY1", "FBgn0086613", "Q9VZJ3", "FBgn0263832", "Q9XZ61", "Uch-L5", "Q7K012", "FBgn0025716", "Q9Y0Z1", "FBgn0027503", "Q8ST83", "FBgn0002521", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "Q9W3D4", "FBgn0040929", "Q9VH07", "FBgn0040078", "A1Z6E8", "FBgn0033019", "A1Z8D5", "FBgn0033566", "Q9VX09", "FBgn0030877", "Q9VFH4", "FBgn0086686", "Q9VEC3", "FBgn0038576", "Q4V604", "FBgn0052202", "Q9VDY1", "FBgn0086613", "Q9VZJ3", "FBgn0263832" ] }, "reaction_10477750": { "compartment": "compartment_7660", "id": "reaction_10477750", "reactome": "R-DME-5690759", "name": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477743" ], "products": [ "species_10477745", "species_10477747" ], "modifiers": [ [ "species_10477743", "catalyst" ] ], "additional_components": [ "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166", "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166" ] }, "reaction_10475507": { "compartment": "compartment_70101", "id": "reaction_10475507", "reactome": "R-DME-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427203", "species_10475478" ], "products": [ "species_10475480" ], "modifiers": [], "additional_components": [ "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "FBgn0033886", "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10477216": { "compartment": "compartment_7660", "id": "reaction_10477216", "reactome": "R-DME-5689630", "name": "BAP1 binds BAP1-interacting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477212", "species_10477180" ], "products": [ "species_10477214" ], "modifiers": [], "additional_components": [ "Q8ST83", "FBgn0002521", "Q9V4C8", "FBgn0039904", "Q7KJA9", "FBgn0261403", "M9PF47", "FBgn0036134", "Q9W3Q5", "FBgn0029504", "Q9V727", "FBgn0261823", "FBgn0262166", "Q7K5N4", "FBgn0262166", "Q8ST83", "FBgn0002521", "Q9V4C8", "FBgn0039904", "Q7KJA9", "FBgn0261403", "M9PF47", "FBgn0036134", "Q9W3Q5", "FBgn0029504", "Q9V727", "FBgn0261823" ] }, "reaction_10455103": { "compartment": "compartment_984", "id": "reaction_10455103", "reactome": "R-DME-917888", "name": "apoTF binds 2Fe3+ to form holoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452901", "species_912516" ], "products": [ "species_10455101" ], "modifiers": [], "additional_components": [ "FBgn0022355", "species_1222611", "Q9VWV6", "FBgn0022355" ] }, "reaction_10477961": { "compartment": "compartment_70101", "id": "reaction_10477961", "reactome": "R-DME-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477840", "species_10426987" ], "products": [ "species_10477952" ], "modifiers": [ [ "species_10477958", "catalyst" ] ], "additional_components": [ "Q9VGZ3", "FBgn0024957", "Q9VCV4", "FBgn0024958", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGZ3", "FBgn0024957", "Q9VCV4", "FBgn0024958", "Q9VJ33", "FBgn0032725", "Q24311", "Cul1", "O77430", "SkpA" ] }, "reaction_10477944": { "compartment": "compartment_5460", "id": "reaction_10477944", "reactome": "R-DME-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10477941", "catalyst" ] ], "additional_components": [ "Q9VYH1", "FBgn0030449" ] }, "reaction_10477831": { "compartment": "compartment_70101", "id": "reaction_10477831", "reactome": "R-DME-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477827", "species_5690881" ], "products": [ "species_10477829" ], "modifiers": [], "additional_components": [ "FBgn0024957", "Q9VGZ3", "FBgn0024957" ] }, "reaction_10477845": { "compartment": "compartment_70101", "id": "reaction_10477845", "reactome": "R-DME-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10477829", "catalyst" ] ], "additional_components": [ "Q9VGZ3", "FBgn0024957" ] }, "reaction_10455096": { "compartment": "compartment_74700", "id": "reaction_10455096", "reactome": "R-DME-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_70106", "species_113592" ], "products": [ "species_29372", "species_29370", "species_74722" ], "modifiers": [ [ "species_10431765", "catalyst" ] ], "additional_components": [ "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q7JR49", "FBgn0262515" ] }, "reaction_10455111": { "compartment": "compartment_74700", "id": "reaction_10455111", "reactome": "R-DME-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10455108", "catalyst" ] ], "additional_components": [ "FBgn0261361" ] }, "reaction_10459940": { "compartment": "compartment_70101", "id": "reaction_10459940", "reactome": "R-DME-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71067", "species_29368" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10449619", "catalyst" ] ], "additional_components": [ "Q9VYH1", "FBgn0030449" ] }, "reaction_10477970": { "compartment": "compartment_70101", "id": "reaction_10477970", "reactome": "R-DME-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438329", "species_10477966" ], "products": [ "species_10477968" ], "modifiers": [], "additional_components": [ "FBgn0027568", "Q9VKY2", "FBgn0027568", "Q24311", "Cul1" ] }, "reaction_10493560": { "compartment": "compartment_70616", "id": "reaction_10493560", "reactome": "R-DME-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10493557", "catalyst" ] ], "additional_components": [ "Q7JX57", "FBgn0062440", "Q8IQ70", "FBgn0042185", "A2VEI2", "FBgn0031893" ] }, "reaction_10493619": { "compartment": "compartment_70616", "id": "reaction_10493619", "reactome": "R-DME-8949649", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493605" ], "products": [ "species_10493607", "species_10493553", "species_10493601" ], "modifiers": [ [ "species_10493616", "catalyst" ] ], "additional_components": [ "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q7JX57", "FBgn0062440", "FBgn0062440", "FBgn0062440", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q7K3W2", "FBgn0033235", "Q9VFF0", "FBgn0038271" ] }, "reaction_10493622": { "compartment": "compartment_70616", "id": "reaction_10493622", "reactome": "R-DME-8949659", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493553" ], "products": [], "modifiers": [ [ "species_10493601", "catalyst" ] ], "additional_components": [ "FBgn0062440", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551" ] }, "reaction_10493624": { "compartment": "compartment_70616", "id": "reaction_10493624", "reactome": "R-DME-8949661", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493603", "species_10493601" ], "products": [ "species_10493605" ], "modifiers": [], "additional_components": [ "FBgn0062440", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q7JX57", "FBgn0062440" ] }, "reaction_10493629": { "compartment": "compartment_70616", "id": "reaction_10493629", "reactome": "R-DME-8949688", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2889072", "species_8949220" ], "products": [ "species_8949232", "species_2889083" ], "modifiers": [ [ "species_10493626", "catalyst" ] ], "additional_components": [ "FBgn0033324" ] }, "reaction_10471663": { "compartment": "compartment_70101", "id": "reaction_10471663", "reactome": "R-DME-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10471660", "catalyst" ] ], "additional_components": [ "FBgn0032015" ] }, "reaction_10471086": { "compartment": "compartment_70101", "id": "reaction_10471086", "reactome": "R-DME-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471077", "species_10471082" ], "products": [ "species_10471084" ], "modifiers": [], "additional_components": [ "Q02645", "FBgn0263391", "FBgn0051352", "E1JIH3", "FBgn0051352", "Q02645", "FBgn0263391" ] }, "reaction_10471094": { "compartment": "compartment_70101", "id": "reaction_10471094", "reactome": "R-DME-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471090", "species_10471082" ], "products": [ "species_10471092" ], "modifiers": [], "additional_components": [ "Q02645", "FBgn0263391", "FBgn0051352", "E1JIH3", "FBgn0051352", "Q02645", "FBgn0263391" ] }, "reaction_10471636": { "compartment": "compartment_70101", "id": "reaction_10471636", "reactome": "R-DME-5336453", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10471627", "catalyst" ] ], "additional_components": [ "FBgn0032451" ] }, "reaction_10471650": { "compartment": "compartment_70101", "id": "reaction_10471650", "reactome": "R-DME-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10471647", "catalyst" ] ], "additional_components": [ "FBgn0032015" ] }, "reaction_10493197": { "compartment": "compartment_70101", "id": "reaction_10493197", "reactome": "R-DME-8941543", "name": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941540" ], "products": [ "species_8941541" ], "modifiers": [ [ "species_10493194", "catalyst" ] ], "additional_components": [ "species_352022", "species_209818", "species_209818", "species_352022", "Q0E8W8", "FBgn0035008" ] }, "reaction_10453114": { "compartment": "compartment_876", "id": "reaction_10453114", "reactome": "R-DME-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10453109", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884" ] }, "reaction_10453112": { "compartment": "compartment_876", "id": "reaction_10453112", "reactome": "R-DME-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10453109", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884" ] }, "reaction_10479551": { "compartment": "compartment_1660541", "id": "reaction_10479551", "reactome": "R-DME-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479517" ], "products": [ "species_10479549" ], "modifiers": [], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101" ] }, "reaction_10491346": { "compartment": "compartment_161320", "id": "reaction_10491346", "reactome": "R-DME-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491342", "species_10491338" ], "products": [ "species_10491336", "species_10491344" ], "modifiers": [], "additional_components": [ "FBgn0024320", "species_8848047", "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198", "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198", "species_8848047", "Q9VL24", "FBgn0024320" ] }, "reaction_10491348": { "compartment": "compartment_12045", "id": "reaction_10491348", "reactome": "R-DME-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491344" ], "products": [ "species_10491342", "species_193384" ], "modifiers": [], "additional_components": [ "species_8848047", "Q9VL24", "FBgn0024320", "FBgn0024320" ] }, "reaction_10491412": { "compartment": "compartment_12045", "id": "reaction_10491412", "reactome": "R-DME-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10491407", "catalyst" ] ], "additional_components": [ "FBgn0037612" ] }, "reaction_10491340": { "compartment": "compartment_161320", "id": "reaction_10491340", "reactome": "R-DME-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10491336" ], "products": [ "species_10491338" ], "modifiers": [], "additional_components": [ "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198", "species_8848047", "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198" ] }, "reaction_10437938": { "compartment": "compartment_74700", "id": "reaction_10437938", "reactome": "R-DME-171087", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437930" ], "products": [ "species_10437936" ], "modifiers": [], "additional_components": [ "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101" ] }, "reaction_10479553": { "compartment": "compartment_1660541", "id": "reaction_10479553", "reactome": "R-DME-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479549" ], "products": [ "species_10479547" ], "modifiers": [], "additional_components": [ "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380" ] }, "reaction_10490897": { "compartment": "compartment_70101", "id": "reaction_10490897", "reactome": "R-DME-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10490631" ], "products": [ "species_10490894", "species_10490892", "species_1132084" ], "modifiers": [ [ "species_10490631", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "Q9V8W3", "FBgn0026378", "O18335", "FBgn0015790", "A1Z7S3", "FBgn0002567", "Q9V3I2", "FBgn0014010", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "O18333", "FBgn0014009", "Q9VQG6", "FBgn0031460", "O18338", "FBgn0262518", "Q9VZ47", "FBgn0052671", "Q8IR98", "FBgn0052670", "Q9W2S9", "FBgn0030221", "Q8IRK8", "FBgn0052673", "Q9W2V3", "FBgn0030200", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "P25228", "FBgn0005586", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420" ] }, "reaction_10490498": { "compartment": "compartment_70101", "id": "reaction_10490498", "reactome": "R-DME-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10490490", "species_10485779" ], "products": [ "species_10490496" ], "modifiers": [], "additional_components": [ "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "FBgn0026378", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164" ] }, "reaction_10490633": { "compartment": "compartment_70101", "id": "reaction_10490633", "reactome": "R-DME-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490629", "species_10490496" ], "products": [ "species_10490631" ], "modifiers": [], "additional_components": [ "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420" ] }, "reaction_10490492": { "compartment": "compartment_70101", "id": "reaction_10490492", "reactome": "R-DME-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490488", "species_10490486" ], "products": [ "species_10490490" ], "modifiers": [], "additional_components": [ "FBgn0028970", "FBgn0037293", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970" ] }, "reaction_10468651": { "compartment": "compartment_70101", "id": "reaction_10468651", "reactome": "R-DME-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468647", "species_10468649" ], "products": [ "species_10468516" ], "modifiers": [], "additional_components": [ "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474" ] }, "reaction_10468521": { "compartment": "compartment_70101", "id": "reaction_10468521", "reactome": "R-DME-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468516" ], "products": [ "species_29372", "species_10468518" ], "modifiers": [ [ "species_10468516", "catalyst" ], [ "species_10468514", "catalyst" ] ], "additional_components": [ "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474" ] }, "reaction_10498696": { "compartment": "compartment_70101", "id": "reaction_10498696", "reactome": "R-DME-9705925", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8979218", "species_10473503" ], "products": [ "species_10498694" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849" ] }, "reaction_10498553": { "compartment": "compartment_70101", "id": "reaction_10498553", "reactome": "R-DME-9690534", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473346", "species_5618094" ], "products": [ "species_10473348" ], "modifiers": [ [ "species_10498474", "catalyst" ] ], "additional_components": [ "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849" ] }, "reaction_10468612": { "compartment": "compartment_70101", "id": "reaction_10468612", "reactome": "R-DME-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468518", "species_10468600", "species_10468604" ], "products": [ "species_10468514", "species_10468610" ], "modifiers": [], "additional_components": [ "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "FBgn0024352", "P02828", "FBgn0001233", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "P02828", "FBgn0001233", "Q9VPN5", "FBgn0024352", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878" ] }, "reaction_10473507": { "compartment": "compartment_70101", "id": "reaction_10473507", "reactome": "R-DME-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468610", "species_113592" ], "products": [ "species_10473495" ], "modifiers": [], "additional_components": [ "P02828", "FBgn0001233", "Q9VPN5", "FBgn0024352", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VPN5", "FBgn0024352", "P02828", "FBgn0001233", "species_113592" ] }, "reaction_10498476": { "compartment": "compartment_70101", "id": "reaction_10498476", "reactome": "R-DME-9678925", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473346", "species_9678859" ], "products": [ "species_10498474" ], "modifiers": [], "additional_components": [ "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849" ] }, "reaction_10473490": { "compartment": "compartment_70101", "id": "reaction_10473490", "reactome": "R-DME-5618080", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473348", "species_10473342" ], "products": [ "species_10473360", "species_10473364" ], "modifiers": [ [ "species_10473488", "catalyst" ] ], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q8WS79", "FBgn0035849", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q9VH95", "FBgn0037728", "species_113592", "Q9VH95", "FBgn0037728", "species_193055", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "species_193977", "CHEBI:27584", "CHEBI:16973", "P02828", "FBgn0001233", "species_113592", "species_469662", "species_193977", "species_193055", "CHEBI:27584", "CHEBI:16973", "species_193057", "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420" ] }, "reaction_10473505": { "compartment": "compartment_70101", "id": "reaction_10473505", "reactome": "R-DME-5618099", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5618094", "species_10473503" ], "products": [ "species_10473342" ], "modifiers": [], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q8WS79", "FBgn0035849", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q9VH95", "FBgn0037728", "species_113592" ] }, "reaction_10498428": { "compartment": "compartment_7660", "id": "reaction_10498428", "reactome": "R-DME-9668902", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427600", "species_10438451", "species_10427605", "species_10427610", "species_10427615" ], "products": [ "species_10438453" ], "modifiers": [], "additional_components": [ "FBgn0032244", "Q2PDX2", "FBgn0054001", "Q8IQ05", "FBgn0015376", "Q4V3Z5", "FBgn0034495", "FBgn0030871", "FBgn0028700", "FBgn0260985", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q2PDX2", "FBgn0054001", "Q8IQ05", "FBgn0015376", "Q4V3Z5", "FBgn0034495", "Q9VKW3", "FBgn0032244" ] }, "reaction_10498430": { "compartment": "compartment_7660", "id": "reaction_10498430", "reactome": "R-DME-9668904", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438449", "species_10438439", "species_10438444" ], "products": [ "species_10438451" ], "modifiers": [], "additional_components": [ "FBgn0034495", "FBgn0015376", "FBgn0054001", "Q2PDX2", "FBgn0054001", "Q8IQ05", "FBgn0015376", "Q4V3Z5", "FBgn0034495" ] }, "reaction_10442443": { "compartment": "compartment_70101", "id": "reaction_10442443", "reactome": "R-DME-204647", "name": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_10442429", "species_29360" ], "products": [ "species_70106", "species_204628", "species_10442425", "species_73473" ], "modifiers": [ [ "species_10442438", "catalyst" ] ], "additional_components": [ "FBgn0285952", "FBgn0285952", "Q9VSF4", "FBgn0035854" ] }, "reaction_10442458": { "compartment": "compartment_70101", "id": "reaction_10442458", "reactome": "R-DME-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10442425", "species_73473" ], "products": [ "species_29356", "species_10442446", "species_29360" ], "modifiers": [ [ "species_10442455", "catalyst" ] ], "additional_components": [ "FBgn0285952", "FBgn0285952", "Q9V9U4", "FBgn0261479", "species_111793" ] }, "reaction_10445932": { "compartment": "compartment_12045", "id": "reaction_10445932", "reactome": "R-DME-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445921" ], "products": [ "species_10445930" ], "modifiers": [], "additional_components": [ "FBgn0037327", "Q9NIV1", "FBgn0037327" ] }, "reaction_10445957": { "compartment": "compartment_70101", "id": "reaction_10445957", "reactome": "R-DME-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430457" ], "products": [ "species_10445954", "species_29370" ], "modifiers": [ [ "species_10445930", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q9NIV1", "FBgn0037327" ] }, "reaction_10476175": { "compartment": "compartment_70101", "id": "reaction_10476175", "reactome": "R-DME-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10476172", "catalyst" ] ], "additional_components": [ "FBgn0086768" ] }, "reaction_10476167": { "compartment": "compartment_70101", "id": "reaction_10476167", "reactome": "R-DME-5676917", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_5676932" ], "products": [ "species_10430994", "species_174390" ], "modifiers": [ [ "species_10476162", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "FBgn0267376" ] }, "reaction_10461449": { "compartment": "compartment_70101", "id": "reaction_10461449", "reactome": "R-DME-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461443", "species_10461445" ], "products": [ "species_10461447" ], "modifiers": [], "additional_components": [ "Q9VSS2", "FBgn0035947", "P49963", "FBgn0015298", "Q9VSC1", "FBgn0035827", "Q9VDL0", "FBgn0038808", "Q9VDK7", "FBgn0038810", "Q9V3D9", "FBgn0010747", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VSS2", "FBgn0035947", "P49963", "FBgn0015298", "Q9VSC1", "FBgn0035827", "Q9VDL0", "FBgn0038808", "Q9VDK7", "FBgn0038810", "Q9V3D9", "FBgn0010747" ] }, "reaction_10494849": { "compartment": "compartment_70101", "id": "reaction_10494849", "reactome": "R-DME-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493819", "species_10494824", "species_10493698" ], "products": [ "species_10494826" ], "modifiers": [], "additional_components": [ "Q9VUQ8", "FBgn0036510", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510" ] }, "reaction_10495201": { "compartment": "compartment_70101", "id": "reaction_10495201", "reactome": "R-DME-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495188" ], "products": [ "species_10495198", "species_10477768" ], "modifiers": [ [ "species_10489634", "catalyst" ] ], "additional_components": [ "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "A1ZBY1", "FBgn0034542", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9VJ33", "FBgn0032725", "Q9VAQ0", "FBgn0039632", "Q7JWH5", "FBgn0044020", "Q9VVB4", "FBgn0036671", "Q9VUQ8", "FBgn0036510", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9V9R2", "FBgn0032956", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "A1ZBY1", "FBgn0034542", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "Q9VAQ0", "FBgn0039632", "Q7JWH5", "FBgn0044020", "FBgn0032725", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836" ] }, "reaction_10494949": { "compartment": "compartment_7660", "id": "reaction_10494949", "reactome": "R-DME-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494922" ], "products": [ "species_10494924", "species_10494946" ], "modifiers": [ [ "species_10494922", "catalyst" ] ], "additional_components": [ "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "FBgn0035853", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9VJ33", "FBgn0032725", "Q5BI50", "FBgn0033260", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853" ] }, "reaction_10495238": { "compartment": "compartment_70101", "id": "reaction_10495238", "reactome": "R-DME-8956140", "name": "NEDD8 and UBD bind NUB1 and the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427203", "species_10477768", "species_10495234" ], "products": [ "species_10495236" ], "modifiers": [], "additional_components": [ "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "FBgn0032725", "FBgn0039343", "Q9VBQ3", "FBgn0039343", "Q9VJ33", "FBgn0032725", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10494951": { "compartment": "compartment_7660", "id": "reaction_10494951", "reactome": "R-DME-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494920", "species_10494855", "species_10494912" ], "products": [ "species_10494922" ], "modifiers": [], "additional_components": [ "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853" ] }, "reaction_10495208": { "compartment": "compartment_7660", "id": "reaction_10495208", "reactome": "R-DME-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494946" ], "products": [ "species_10495205", "species_10495203" ], "modifiers": [ [ "species_10477930", "catalyst" ] ], "additional_components": [ "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9VJ33", "FBgn0032725", "Q5BI50", "FBgn0033260", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VVB4", "FBgn0036671", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "FBgn0032725", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057" ] }, "reaction_10495240": { "compartment": "compartment_70101", "id": "reaction_10495240", "reactome": "R-DME-8956184", "name": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495236" ], "products": [ "species_10427203", "species_10495234" ], "modifiers": [], "additional_components": [ "Q9VBQ3", "FBgn0039343", "Q9VJ33", "FBgn0032725", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "FBgn0039343" ] }, "reaction_10495242": { "compartment": "compartment_876", "id": "reaction_10495242", "reactome": "R-DME-8956200", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494842", "species_10494824" ], "products": [ "species_10494844" ], "modifiers": [], "additional_components": [ "FBgn0033784", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q8T8S1", "FBgn0033784" ] }, "reaction_10493675": { "compartment": "compartment_70101", "id": "reaction_10493675", "reactome": "R-DME-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477770" ], "products": [ "species_10477768", "species_10477759" ], "modifiers": [], "additional_components": [ "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725", "FBgn0032725", "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288" ] }, "reaction_10495122": { "compartment": "compartment_70101", "id": "reaction_10495122", "reactome": "R-DME-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495118", "species_10477966" ], "products": [ "species_10495120" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "A1ZBY1", "FBgn0034542", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "Q9VAQ0", "FBgn0039632", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q7JWH5", "FBgn0044020", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "Q9V9R2", "FBgn0032956", "FBgn0027568", "Q9VKY2", "FBgn0027568", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "A1ZBY1", "FBgn0034542", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "Q9VAQ0", "FBgn0039632", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q7JWH5", "FBgn0044020", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "Q9V9R2", "FBgn0032956" ] }, "reaction_10495219": { "compartment": "compartment_70101", "id": "reaction_10495219", "reactome": "R-DME-8956099", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495215", "species_10495210" ], "products": [ "species_10495217" ], "modifiers": [], "additional_components": [ "FBgn0031664", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q7K4I5", "FBgn0031664" ] }, "reaction_10495223": { "compartment": "compartment_70101", "id": "reaction_10495223", "reactome": "R-DME-8956103", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458032", "species_10495210" ], "products": [ "species_10495221" ], "modifiers": [], "additional_components": [ "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411" ] }, "reaction_10495128": { "compartment": "compartment_7660", "id": "reaction_10495128", "reactome": "R-DME-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494894", "species_10495124" ], "products": [ "species_10495126" ], "modifiers": [], "additional_components": [ "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "FBgn0027568", "Q9VKY2", "FBgn0027568", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962" ] }, "reaction_10495228": { "compartment": "compartment_70101", "id": "reaction_10495228", "reactome": "R-DME-8956106", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495221", "species_10458091" ], "products": [ "species_10495225", "species_10427563" ], "modifiers": [ [ "species_10495221", "catalyst" ], [ "species_10495217", "inhibitor" ] ], "additional_components": [ "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411", "Q9Y165", "FBgn0027609", "P25867", "eff", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q7K4I5", "FBgn0031664" ] }, "reaction_10494846": { "compartment": "compartment_70101", "id": "reaction_10494846", "reactome": "R-DME-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494826" ], "products": [ "species_10493677", "species_10494838" ], "modifiers": [ [ "species_10494826", "catalyst" ], [ "species_10494844", "inhibitor" ] ], "additional_components": [ "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510", "FBgn0035853", "Q24311", "Cul1", "Q9VJ33", "FBgn0032725", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VVB4", "FBgn0036671", "Q9VUQ8", "FBgn0036510", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q8T8S1", "FBgn0033784" ] }, "reaction_10489264": { "compartment": "compartment_984", "id": "reaction_10489264", "reactome": "R-DME-8855711", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855720", "species_10489260" ], "products": [ "species_10489262" ], "modifiers": [], "additional_components": [ "M9NE79", "FBgn0262357", "Q9VPS2", "FBgn0040107", "M9PB26", "FBgn0264341", "Q9VQ53", "FBgn0031373", "Q59DY5", "FBgn0053533", "Q9VQU4", "FBgn0040104", "Q59DY6", "FBgn0053532", "Q9VQX3", "FBgn0040102", "Q7JY62", "FBgn0040092", "Q9W3D8", "FBgn0030050", "A1Z7Z6", "FBgn0040093", "Q8IRH8", "FBgn0035199", "A1Z8L7", "FBgn0040503", "Q9VIX1", "FBgn0016675", "B4ZJ93", "FBgn0259958", "Q9VKL8", "FBgn0040096", "B7YZU7", "FBgn0259230", "Q9VLM0", "FBgn0040098", "B7Z0K3", "FBgn0038315", "Q9VM16", "FBgn0031910", "C3KGN2", "FBgn0283508", "Q9VPS1", "FBgn0040106", "M9NE79", "FBgn0262357", "Q9VPS2", "FBgn0040107", "M9PB26", "FBgn0264341", "Q9VQ53", "FBgn0031373", "Q59DY5", "FBgn0053533", "Q9VQU4", "FBgn0040104", "Q59DY6", "FBgn0053532", "Q9VQX3", "FBgn0040102", "Q7JY62", "FBgn0040092", "Q9W3D8", "FBgn0030050", "A1Z7Z6", "FBgn0040093", "Q8IRH8", "FBgn0035199", "A1Z8L7", "FBgn0040503", "Q9VIX1", "FBgn0016675", "B4ZJ93", "FBgn0259958", "Q9VKL8", "FBgn0040096", "B7YZU7", "FBgn0259230", "Q9VLM0", "FBgn0040098", "B7Z0K3", "FBgn0038315", "Q9VM16", "FBgn0031910", "C3KGN2", "FBgn0283508", "Q9VPS1", "FBgn0040106", "species_8855720" ] }, "reaction_10488819": { "compartment": "compartment_70101", "id": "reaction_10488819", "reactome": "R-DME-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10457705" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10488816", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "species_8853396", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "FBgn0030839" ] }, "reaction_10488392": { "compartment": "compartment_70101", "id": "reaction_10488392", "reactome": "R-DME-8850594", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10457705" ], "products": [ "species_1022114", "species_8852852" ], "modifiers": [ [ "species_10488389", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "CHEBI:60628", "CHEBI:60629", "species_964740", "species_915149", "CHEBI:60627", "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VCD5", "FBgn0039147", "Q9V3W9", "FBgn0026777", "Q7KRR5", "FBgn0033050", "Q9VSC5", "FBgn0035830", "P48601", "Rpt2" ] }, "reaction_10454410": { "compartment": "compartment_17957", "id": "reaction_10454410", "reactome": "R-DME-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454406", "species_10453353" ], "products": [ "species_10454408" ], "modifiers": [], "additional_components": [ "P29413", "FBgn0005585", "Q9I7S9", "FBgn0030377", "Q9VXF6", "FBgn0264077", "Q9VAL7", "FBgn0015622", "CHEBI:59080", "FBgn0033663", "Q3YMU0", "FBgn0033663", "P29413", "FBgn0005585", "Q9I7S9", "FBgn0030377", "Q9VXF6", "FBgn0264077", "Q9VAL7", "FBgn0015622", "CHEBI:59080" ] }, "reaction_10455485": { "compartment": "compartment_17963", "id": "reaction_10455485", "reactome": "R-DME-964759", "name": "Alternative endo-mannosidase I route", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964754" ], "products": [ "species_964744", "species_964746" ], "modifiers": [ [ "species_10455482", "catalyst" ] ], "additional_components": [ "FBgn0031716" ] }, "reaction_10455493": { "compartment": "compartment_20699", "id": "reaction_10455493", "reactome": "R-DME-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_964740" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10455490", "catalyst" ] ], "additional_components": [ "FBgn0034521" ] }, "reaction_10478044": { "compartment": "compartment_70101", "id": "reaction_10478044", "reactome": "R-DME-5693061", "name": "STAMBP binds STAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439062", "species_10478040" ], "products": [ "species_10478042" ], "modifiers": [], "additional_components": [ "FBgn0027363", "FBgn0039773", "Q9VA71", "FBgn0039773", "Q9XTL2", "FBgn0027363" ] }, "reaction_10479159": { "compartment": "compartment_70101", "id": "reaction_10479159", "reactome": "R-DME-5696547", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437507" ], "products": [ "species_10437505" ], "modifiers": [ [ "species_10479156", "catalyst" ], [ "species_10478042", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0039773", "Q9VA71", "FBgn0039773", "Q9XTL2", "FBgn0027363" ] }, "reaction_10477973": { "compartment": "compartment_70101", "id": "reaction_10477973", "reactome": "R-DME-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437507" ], "products": [ "species_10437505" ], "modifiers": [ [ "species_10426995", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10435837": { "compartment": "compartment_17957", "id": "reaction_10435837", "reactome": "R-DME-159761", "name": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_6806362", "species_159751", "species_10435823" ], "products": [ "species_113519", "species_10435829", "species_6806366" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10435960": { "compartment": "compartment_17957", "id": "reaction_10435960", "reactome": "R-DME-159803", "name": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10435952", "species_6806362", "species_159751" ], "products": [ "species_113519", "species_6806366", "species_10435958" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10436711": { "compartment": "compartment_17957", "id": "reaction_10436711", "reactome": "R-DME-163820", "name": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_6806362", "species_159751", "species_10436703" ], "products": [ "species_113519", "species_10436709", "species_6806366" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10435926": { "compartment": "compartment_17957", "id": "reaction_10435926", "reactome": "R-DME-159795", "name": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_6806362", "species_10435924", "species_159751" ], "products": [ "species_113519", "species_6806366", "species_10435863" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10435970": { "compartment": "compartment_17957", "id": "reaction_10435970", "reactome": "R-DME-159819", "name": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10435968", "species_6806362", "species_159751" ], "products": [ "species_113519", "species_6806366", "species_10435815" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10436719": { "compartment": "compartment_20699", "id": "reaction_10436719", "reactome": "R-DME-163843", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436695" ], "products": [ "species_10436715", "species_10436717" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "FBgn0027594", "FBgn0027594", "FBgn0027594", "FBgn0004509" ] }, "reaction_10435946": { "compartment": "compartment_20699", "id": "reaction_10435946", "reactome": "R-DME-159796", "name": "Furin cleaves pro-factor IX to factor IX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435932" ], "products": [ "species_10435938", "species_10435944" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10435801": { "compartment": "compartment_20699", "id": "reaction_10435801", "reactome": "R-DME-159733", "name": "Furin cleaves pro-factor X to factor X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435779" ], "products": [ "species_10435793", "species_10435787" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10435895": { "compartment": "compartment_20699", "id": "reaction_10435895", "reactome": "R-DME-159771", "name": "Furin cleaves pro-protein C to protein C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435877" ], "products": [ "species_10435893", "species_10435887" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10436677": { "compartment": "compartment_20699", "id": "reaction_10436677", "reactome": "R-DME-163798", "name": "Furin cleaves pro-protein Z to protein Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436663" ], "products": [ "species_10436675", "species_10436669" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10435986": { "compartment": "compartment_20699", "id": "reaction_10435986", "reactome": "R-DME-159868", "name": "Furin cleaves pro-factor VII to factor VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435901" ], "products": [ "species_10435984", "species_10435978" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10480016": { "compartment": "compartment_12045", "id": "reaction_10480016", "reactome": "R-DME-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_71285", "species_6788758" ], "modifiers": [ [ "species_10480013", "catalyst" ] ], "additional_components": [ "Q9VU37", "FBgn0036336", "species_1562550" ] }, "reaction_10494803": { "compartment": "compartment_17957", "id": "reaction_10494803", "reactome": "R-DME-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494300", "species_8931885" ], "products": [ "species_10494796", "species_8931884" ], "modifiers": [ [ "species_10494300", "catalyst" ], [ "species_10494801", "catalyst" ] ], "additional_components": [ "A4VCL2", "FBgn0051145", "P54399", "FBgn0286818", "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649", "Q9VP10", "FBgn0037105", "Q9VTZ5", "FBgn0036299", "Q9VJW9", "FBgn0259984", "Q9VLC3", "FBgn0032116", "Q9VX11", "FBgn0052557", "Q9VBK7", "FBgn0039387", "Q9VM47", "FBgn0031885", "Q9V416", "FBgn0028879", "P14599", "FBgn0000108", "Q9VVK3", "FBgn0052183", "Q9VHA8", "FBgn0037718", "Q9VUH4", "FBgn0036446", "Q9VUH5", "FBgn0036447", "Q9VDT9", "FBgn0014135", "Q9VMA7", "FBgn0286898", "Q9VUX3", "FBgn0044028", "P27091", "FBgn0024234", "P54631", "FBgn0005590", "Q9V4E6", "FBgn0039914", "P07713", "FBgn0000490", "Q9VVK7", "FBgn0052190", "Q9V438", "FBgn0025678", "E1JI03", "FBgn0036449", "Q9W302", "FBgn0030163", 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"Q9VJW9", "FBgn0259984", "Q9VLC3", "FBgn0032116", "Q9VX11", "FBgn0052557", "Q9VBK7", "FBgn0039387", "Q9VM47", "FBgn0031885", "Q9V416", "FBgn0028879", "P14599", "FBgn0000108", "Q9VVK3", "FBgn0052183", "Q9VHA8", "FBgn0037718", "Q9VUH4", "FBgn0036446", "Q9VUH5", "FBgn0036447", "Q9VDT9", "FBgn0014135", "Q9VMA7", "FBgn0286898", "Q9VUX3", "FBgn0044028", "P27091", "FBgn0024234", "P54631", "FBgn0005590", "Q9V4E6", "FBgn0039914", "P07713", "FBgn0000490", "Q9VVK7", "FBgn0052190", "Q9V438", "FBgn0025678", "E1JI03", "FBgn0036449", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "B7Z0B2", "FBgn0035452", "Q7KT80", "FBgn0051832", "Q8IRM2", "FBgn0030164", "Q95SM8", "FBgn0050281", "Q9VME7", "FBgn0031804", "Q9VX04", "FBgn0030880", "Q9VLT3", "FBgn0267488", "Q9VLY7", "FBgn0041181", "M9PDR0", "FBgn0041180", "Q9NFV7", "FBgn0041182", "Q9NFV8", "FBgn0041183", "Q9VJD1", "FBgn0032643", "Q9VTJ4", "FBgn0285958", "Q9W0A0", "FBgn0027594", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q24114", "dally", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "O97365", "FBgn0026562", "P11046", "FBgn0261800", "Q7JQR3", "FBgn0033814", "Q9VWV6", "FBgn0022355", "Q9VAY2", "FBgn0039562", "Q9VH14", "FBgn0025879", "P15215", "FBgn0267348", "P49415", "FBgn0010415", "X2JEB0", "FBgn0262730", "Q9W0H8", "FBgn0025682", "Q9VJB6", "FBgn0262018", "Q8IMZ9", "FBgn0039003", "Q9VPI6", "FBgn0031213", "Q9VPI7", "FBgn0031214", "Q9VPU6", "FBgn0031289", "A4VCL2", "FBgn0051145" ] }, "reaction_10444863": { "compartment": "compartment_876", "id": "reaction_10444863", "reactome": "R-DME-374922", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10444851", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10444853" ], "modifiers": [ [ "species_10444851", "catalyst" ] ], "additional_components": [ "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964" ] }, "reaction_10444858": { "compartment": "compartment_984", "id": "reaction_10444858", "reactome": "R-DME-374899", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444853" ], "products": [ "species_10443025", "species_10442919", "species_10444855", "species_10443003", "species_10443019", "species_10442973", "species_374935", "species_10443023" ], "modifiers": [ [ "species_10444853", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0004574", "FBgn0260964", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343" ] }, "reaction_10444371": { "compartment": "compartment_374932", "id": "reaction_10444371", "reactome": "R-DME-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10444368", "catalyst" ] ], "additional_components": [ "FBgn0260964" ] }, "reaction_10496500": { "compartment": "compartment_70101", "id": "reaction_10496500", "reactome": "R-DME-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8982080", "species_10467519" ], "products": [ "species_10496498" ], "modifiers": [], "additional_components": [ "CHEBI:49537", "CHEBI:47037", "FBgn0015331", "Q9V3C0", "FBgn0015331", "CHEBI:49537", "CHEBI:47037" ] }, "reaction_10468991": { "compartment": "compartment_7660", "id": "reaction_10468991", "reactome": "R-DME-3788725", "name": "Cdh1:APC/C complex binds EHMT1:EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468978", "species_10438214" ], "products": [ "species_10468980" ], "modifiers": [], "additional_components": [ "M9PGH7", "FBgn0040372", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "M9PGH7", "FBgn0040372" ] }, "reaction_10468989": { "compartment": "compartment_7660", "id": "reaction_10468989", "reactome": "R-DME-3788724", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468980", "species_10427430" ], "products": [ "species_10468986" ], "modifiers": [ [ "species_10468980", "catalyst" ] ], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "M9PGH7", "FBgn0040372", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "M9PGH7", "FBgn0040372", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "M9PGH7", "FBgn0040372" ] }, "reaction_10468969": { "compartment": "compartment_7660", "id": "reaction_10468969", "reactome": "R-DME-3788708", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438214", "species_10427405" ], "products": [ "species_10438216" ], "modifiers": [ [ "species_10439439", "inhibitor" ] ], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107" ] }, "reaction_10469079": { "compartment": "compartment_7660", "id": "reaction_10469079", "reactome": "R-DME-3857336", "name": "CEBPB homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469061" ], "products": [ "species_10469063" ], "modifiers": [], "additional_components": [ "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493" ] }, "reaction_10468966": { "compartment": "compartment_7660", "id": "reaction_10468966", "reactome": "R-DME-3788705", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438216" ], "products": [ "species_113582", "species_10438218" ], "modifiers": [ [ "species_10438216", "catalyst" ], [ "species_10439439", "inhibitor" ] ], "additional_components": [ "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107" ] }, "reaction_10469077": { "compartment": "compartment_7660", "id": "reaction_10469077", "reactome": "R-DME-3857329", "name": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10469069" ], "products": [ "species_113582", "species_10469075" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "P40417", "FBgn0003256" ] }, "reaction_10447725": { "compartment": "compartment_876", "id": "reaction_10447725", "reactome": "R-DME-420980", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10446959", "catalyst" ] ], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_10447723": { "compartment": "compartment_984", "id": "reaction_10447723", "reactome": "R-DME-420977", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10446957" ], "products": [ "species_10446959" ], "modifiers": [], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_10447721": { "compartment": "compartment_984", "id": "reaction_10447721", "reactome": "R-DME-420975", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10446946" ], "products": [ "species_10446948" ], "modifiers": [], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_10446951": { "compartment": "compartment_876", "id": "reaction_10446951", "reactome": "R-DME-399711", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10446948", "catalyst" ] ], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_350405": { "compartment": "compartment_876", "id": "reaction_350405", "reactome": "R-DME-350405", "name": "RHOGEF2 binds to RHO1:GDP complex at the plasma membrane", "reversible": "false", "notes": "At the plasma membrane, Rho guanyl-nucleotide exchange factor (RHOGEF2) associates with the inactive Rho GTPase complex (RHO1:GDP).", "reactants": [ "species_350999", "species_350951" ], "products": [ "species_351056" ], "modifiers": [], "additional_components": [ "species_29420", "P48148", "Rho1", "O44113", "RHOGEF2", "species_29420", "P48148", "Rho1" ] }, "reaction_350453": { "compartment": "compartment_70101", "id": "reaction_350453", "reactome": "R-DME-350453", "name": "RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane", "reversible": "false", "notes": "Rho GTPase activator (RHOGAPP190) associates with the activated Rho GTPase complex (RHO1:GTP) at the plasma membrane.", "reactants": [ "species_350991", "species_350950" ], "products": [ "species_351000" ], "modifiers": [], "additional_components": [ "species_29438", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "Q9VX32", "RhoGAPp190" ] }, "reaction_350359": { "compartment": "compartment_70101", "id": "reaction_350359", "reactome": "R-DME-350359", "name": "RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane", "reversible": "false", "notes": "Inactive Rho GTPase complex (RHO1:GDP) dissociates from Rho GDP dissociation inhibitor (RHOGDI) and binds to the plasma membrane.", "reactants": [ "species_351058" ], "products": [ "species_351008", "species_350999" ], "modifiers": [], "additional_components": [ "Q9VW59", "RhoGDI", "species_29420", "P48148", "Rho1", "species_29420", "P48148", "Rho1" ] }, "reaction_350450": { "compartment": "compartment_876", "id": "reaction_350450", "reactome": "R-DME-350450", "name": "RHO1:GTP complex dissociates from RHOGEF2", "reversible": "false", "notes": "Rho guanyl-nucleotide exchange factor (RHOGEF2) dissociates from the activated Rho GTPase complex (RHO1:GTP).", "reactants": [ "species_351086" ], "products": [ "species_350950", "species_350951" ], "modifiers": [], "additional_components": [ "O44113", "RHOGEF2", "species_29438", "P48148", "Rho1", "species_29438", "P48148", "Rho1" ] }, "reaction_350477": { "compartment": "compartment_70101", "id": "reaction_350477", "reactome": "R-DME-350477", "name": "RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex", "reversible": "false", "notes": "Rho guanyl-nucleotide exchange factor (RHOGEF2) catalyses GTP for GDP nucleotide exchange with the Rho GTPase complex (RHO1:GDP).", "reactants": [ "species_29438", "species_351056" ], "products": [ "species_29420", "species_351086" ], "modifiers": [ [ "species_351056", "catalyst" ] ], "additional_components": [ "O44113", "RHOGEF2", "species_29420", "P48148", "Rho1", "O44113", "RHOGEF2", "species_29438", "P48148", "Rho1", "O44113", "RHOGEF2", "species_29420", "P48148", "Rho1" ] }, "reaction_350395": { "compartment": "compartment_70101", "id": "reaction_350395", "reactome": "R-DME-350395", "name": "RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol", "reversible": "false", "notes": "Rho GDP dissociation inhibitor (RHOGDI) sequesters inactive Rho GTPase complex (RHO1:GDP) in the cytosol.", "reactants": [ "species_351008", "species_350999" ], "products": [ "species_351058" ], "modifiers": [], "additional_components": [ "species_29420", "P48148", "Rho1", "Q9VW59", "RhoGDI", "species_29420", "P48148", "Rho1" ] }, "reaction_350458": { "compartment": "compartment_70101", "id": "reaction_350458", "reactome": "R-DME-350458", "name": "RHOGAPP190 activates GTP hydrolysis by RHO1:GTP", "reversible": "false", "notes": "RHOGAPP190 activates the GTPase activity of RHO1, leading to hydrolysis of its bound GTP.", "reactants": [ "species_351000" ], "products": [ "species_29372", "species_351009" ], "modifiers": [ [ "species_351000", "catalyst" ] ], "additional_components": [ "species_29438", "P48148", "Rho1", "Q9VX32", "RhoGAPp190", "species_29420", "P48148", "Rho1", "Q9VX32", "RhoGAPp190", "species_29438", "P48148", "Rho1", "Q9VX32", "RhoGAPp190" ] }, "reaction_350410": { "compartment": "compartment_70101", "id": "reaction_350410", "reactome": "R-DME-350410", "name": "RHO1:GDP complex dissociates from RHOGAPP190", "reversible": "false", "notes": "Rho GTPase activator (RHOGAPP190) dissociates from inactive Rho GTPase complex(RHO1:GDP).", "reactants": [ "species_351009" ], "products": [ "species_350991", "species_350999" ], "modifiers": [], "additional_components": [ "species_29420", "P48148", "Rho1", "Q9VX32", "RhoGAPp190", "species_29420", "P48148", "Rho1" ] }, "reaction_10470223": { "compartment": "compartment_70101", "id": "reaction_10470223", "reactome": "R-DME-4793925", "name": "p-S303,307-HSF1 binds YWHAE (14-3-3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432016", "species_10470219" ], "products": [ "species_10470221" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "FBgn0001222", "P22813", "FBgn0001222", "P92177", "14-3-3epsilon" ] }, "reaction_10471487": { "compartment": "compartment_70101", "id": "reaction_10471487", "reactome": "R-DME-5252079", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471418" ], "products": [ "species_29370", "species_10471276" ], "modifiers": [ [ "species_10471470", "catalyst" ], [ "species_10471485", "inhibitor" ] ], "additional_components": [ "species_29370", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "M9MSL3", "FBgn0026418", "A8JNS4", "FBgn0086708", "Q95RY2", "FBgn0036505", "Q86DS1", "FBgn0029676", "C4NYP8", "FBgn0260484" ] }, "reaction_10471450": { "compartment": "compartment_70101", "id": "reaction_10471450", "reactome": "R-DME-5252041", "name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471278" ], "products": [ "species_10471354" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9W0C7", "FBgn0035243", "Q9W0C7", "FBgn0035243", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "species_113592", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10470217": { "compartment": "compartment_70101", "id": "reaction_10470217", "reactome": "R-DME-4793911", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468527" ], "products": [ "species_29370", "species_10470214" ], "modifiers": [ [ "species_10439409", "catalyst" ] ], "additional_components": [ "FBgn0001222", "FBgn0001222", "FBgn0013987" ] }, "reaction_10471528": { "compartment": "compartment_7660", "id": "reaction_10471528", "reactome": "R-DME-5333051", "name": "RPA1 binds HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_10468620" ], "products": [ "species_10471526" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P22813", "FBgn0001222", "P22813", "FBgn0001222", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10471429": { "compartment": "compartment_70101", "id": "reaction_10471429", "reactome": "R-DME-5251959", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10471276" ], "products": [ "species_29372", "species_10471418" ], "modifiers": [ [ "species_10471426", "catalyst" ] ], "additional_components": [ "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_29370", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VP77", "FBgn0037051", "A8DYF7", "FBgn0034091", "Q9V3W1", "FBgn0032586" ] }, "reaction_10468628": { "compartment": "compartment_70101", "id": "reaction_10468628", "reactome": "R-DME-3371531", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468527" ], "products": [ "species_10468626", "species_29370" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "FBgn0001222", "FBgn0001222", "P40417", "FBgn0003256" ] }, "reaction_10468532": { "compartment": "compartment_70101", "id": "reaction_10468532", "reactome": "R-DME-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468527" ], "products": [ "species_10468530", "species_29370" ], "modifiers": [ [ "species_10440540", "catalyst" ] ], "additional_components": [ "FBgn0001222", "FBgn0001222", "P83101", "FBgn0046332", "P18431", "sgg" ] }, "reaction_10471396": { "compartment": "compartment_7660", "id": "reaction_10471396", "reactome": "R-DME-5251955", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10471354" ], "products": [ "species_113550", "species_10471376", "species_10471352" ], "modifiers": [ [ "species_10471393", "catalyst" ] ], "additional_components": [ "Q9W0C7", "FBgn0035243", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "species_113592", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "species_29370", "FBgn0035243", "Q9V3W1", "FBgn0032586", "Q9VP77", "FBgn0037051", "A8DYF7", "FBgn0034091" ] }, "reaction_10471280": { "compartment": "compartment_70101", "id": "reaction_10471280", "reactome": "R-DME-5251942", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471200", "species_10471276" ], "products": [ "species_10471278" ], "modifiers": [], "additional_components": [ "FBgn0035243", "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9W0C7", "FBgn0035243" ] }, "reaction_10498679": { "compartment": "compartment_7660", "id": "reaction_10498679", "reactome": "R-DME-9699579", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441099" ], "products": [ "species_113582", "species_10441113" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10497384": { "compartment": "compartment_70101", "id": "reaction_10497384", "reactome": "R-DME-9607304", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475840", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P26675", "Sos" ] }, "reaction_10454271": { "compartment": "compartment_70101", "id": "reaction_10454271", "reactome": "R-DME-879914", "name": "IL3 stimulation induces Vav binding to Tec kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442646", "species_10442471" ], "products": [ "species_10454269" ], "modifiers": [], "additional_components": [ "FBgn0003502", "FBgn0040068", "Q9NHV9", "FBgn0040068", "P08630", "FBgn0003502" ] }, "reaction_10454509": { "compartment": "compartment_70101", "id": "reaction_10454509", "reactome": "R-DME-912790", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454432", "species_10446146" ], "products": [ "species_10454503" ], "modifiers": [], "additional_components": [ "FBgn0020224", "FBgn0024811", "Q9XYM0", "FBgn0024811", "Q9VSK2", "FBgn0020224" ] }, "reaction_10454507": { "compartment": "compartment_70101", "id": "reaction_10454507", "reactome": "R-DME-912734", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446160", "species_10454503" ], "products": [ "species_10454505" ], "modifiers": [], "additional_components": [ "FBgn0259228", "Q9XYM0", "FBgn0024811", "Q9VSK2", "FBgn0020224", "Q9XYM0", "FBgn0024811", "Q9VSK2", "FBgn0020224", "O77086", "FBgn0259228" ] }, "reaction_10454281": { "compartment": "compartment_70101", "id": "reaction_10454281", "reactome": "R-DME-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444516", "species_10453140", "species_10439032", "species_10431791" ], "products": [ "species_10454279" ], "modifiers": [], "additional_components": [ "FBgn0262733", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "FBgn0020224", "FBgn0004638", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P00528", "FBgn0262733" ] }, "reaction_10454501": { "compartment": "compartment_70101", "id": "reaction_10454501", "reactome": "R-DME-912727", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454432", "species_10442471" ], "products": [ "species_10454499" ], "modifiers": [], "additional_components": [ "FBgn0020224", "FBgn0040068", "Q9NHV9", "FBgn0040068", "Q9VSK2", "FBgn0020224" ] }, "reaction_10454497": { "compartment": "compartment_70101", "id": "reaction_10454497", "reactome": "R-DME-912627", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454480", "species_10454434" ], "products": [ "species_10454495" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P00528", "FBgn0262733", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "P00528", "FBgn0262733", "Q9VSK2", "FBgn0020224" ] }, "reaction_10495825": { "compartment": "compartment_70101", "id": "reaction_10495825", "reactome": "R-DME-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495805" ], "products": [ "species_10495823" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495817": { "compartment": "compartment_70101", "id": "reaction_10495817", "reactome": "R-DME-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495811" ], "products": [ "species_10495815" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495819": { "compartment": "compartment_70101", "id": "reaction_10495819", "reactome": "R-DME-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495809" ], "products": [ "species_10495811" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10495807": { "compartment": "compartment_70101", "id": "reaction_10495807", "reactome": "R-DME-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493643" ], "products": [ "species_10495805" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10450767": { "compartment": "compartment_70101", "id": "reaction_10450767", "reactome": "R-DME-449073", "name": "Caspase-3 cleaves pro-interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450760" ], "products": [ "species_10450762", "species_10450764" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0087007", "FBgn0087007", "FBgn0087007", "Q9XYF4", "FBgn0026404" ] }, "reaction_10496506": { "compartment": "compartment_984", "id": "reaction_10496506", "reactome": "R-DME-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450776", "species_10496502" ], "products": [ "species_10496504" ], "modifiers": [], "additional_components": [ "FBgn0039379", "FBgn0013343", "Q24547", "FBgn0013343", "Q9VBL3", "FBgn0039379" ] }, "reaction_10450771": { "compartment": "compartment_984", "id": "reaction_10450771", "reactome": "R-DME-449077", "name": "Interleukin-16 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450764" ], "products": [ "species_10450769" ], "modifiers": [], "additional_components": [ "FBgn0087007", "FBgn0087007" ] }, "reaction_10450786": { "compartment": "compartment_984", "id": "reaction_10450786", "reactome": "R-DME-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10450776" ], "products": [ "species_10450778" ], "modifiers": [ [ "species_10450784", "inhibitor" ] ], "additional_components": [ "FBgn0013343", "FBgn0039379", "Q9VBL3", "FBgn0039379", "Q24547", "FBgn0013343", "Q07327", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343" ] }, "reaction_10493651": { "compartment": "compartment_70101", "id": "reaction_10493651", "reactome": "R-DME-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493647" ], "products": [ "species_10493649" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493665": { "compartment": "compartment_70101", "id": "reaction_10493665", "reactome": "R-DME-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718", "species_10454425" ], "products": [ "species_10457722" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10493659": { "compartment": "compartment_70101", "id": "reaction_10493659", "reactome": "R-DME-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457722" ], "products": [ "species_10457730" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493640": { "compartment": "compartment_70101", "id": "reaction_10493640", "reactome": "R-DME-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493634" ], "products": [ "species_10493638" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493661": { "compartment": "compartment_70101", "id": "reaction_10493661", "reactome": "R-DME-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493632" ], "products": [ "species_10493634" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10475576": { "compartment": "compartment_70101", "id": "reaction_10475576", "reactome": "R-DME-5668520", "name": "26Sproteasome degrades K48polyUb-NIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475574" ], "products": [], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0024329", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_451846": { "compartment": "compartment_70101", "id": "reaction_451846", "reactome": "R-DME-451846", "name": "LFT binds to FT and DS", "reversible": "false", "notes": "The small protein Lowfat (LFT) binds to the cytoplasmic domains of the cadherin domain containing transmembrane proteins Fat (FT) and Dachsous (DS). The function of LFT is currently unknown but it does appear to increase FT and DS protein levels.", "reactants": [ "species_451851", "species_451871" ], "products": [ "species_451879" ], "modifiers": [], "additional_components": [ "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "Q9VKY1", "LFT" ] }, "reaction_451858": { "compartment": "compartment_70101", "id": "reaction_451858", "reactome": "R-DME-451858", "name": "YKI binds to HPO homodimer", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Hippo (HPO) homodimer PPXY sequence motif, of which HPO has one per monomer unit. YKI remains in the cytosol where it is unable to activate its target genes.", "reactants": [ "species_390185", "species_390114" ], "products": [ "species_451843" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q45VV3", "yki", "Q8T0S6", "HPO" ] }, "reaction_451826": { "compartment": "compartment_70101", "id": "reaction_451826", "reactome": "R-DME-451826", "name": "YKI binds to EX", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Expanded (EX) PPXY sequence motif, of which EX has three. YKI remains in the cytosol where it is unable to activate its target genes.", "reactants": [ "species_390114", "species_451874" ], "products": [ "species_451822" ], "modifiers": [], "additional_components": [ "Q07436", "EX", "Q45VV3", "yki" ] }, "reaction_451811": { "compartment": "compartment_70101", "id": "reaction_451811", "reactome": "R-DME-451811", "name": "YKI binds to WTS", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Warts (WTS) PPXY sequence motif, of which WTS has five. YKI remains in the cytosol where it is unable to activate its target genes.", "reactants": [ "species_390114", "species_390037" ], "products": [ "species_451862" ], "modifiers": [], "additional_components": [ "Q9VA38", "WTS", "Q45VV3", "yki" ] }, "reaction_390120": { "compartment": "compartment_70101", "id": "reaction_390120", "reactome": "R-DME-390120", "name": "Phosphorylated HPO dimer phosphorylates TH", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase phosphorylates Thread (TH) aka drosophila inhibitor of apoptosis protein 1 (Diap1) at unknown residues. This affects TH's stability.", "reactants": [ "species_113592", "species_390182" ], "products": [ "species_29370", "species_390103" ], "modifiers": [ [ "species_390068", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390059": { "compartment": "compartment_70101", "id": "reaction_390059", "reactome": "R-DME-390059", "name": "HPO dimer binds to RASSF", "reversible": "false", "notes": "Ras association family member (RASSF) associates with inactive Hippo (HPO) kinase homodimer through their shared SARAH (Salvador/Rassf/Hippo) domains. It should be noted that Hippo (HPO) kinase domain also associates with scaffolding protein Salvador (SAV) through SARAH domains. However, RASSF fails to bind to SAV. HPO associated with RASSF shows barely detectable levels of phosphorylation. In this complex, HPO homodimer remains unphosphorylated and inactive. Thus, RASSF restricts HPO activity by competing with SAV for binding to HPO homodimer.", "reactants": [ "species_390185", "species_390054" ], "products": [ "species_390177" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q9VCQ7", "RASSF", "Q8T0S6", "HPO" ] }, "reaction_10458089": { "compartment": "compartment_70101", "id": "reaction_10458089", "reactome": "R-DME-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458077" ], "products": [ "species_10458083" ], "modifiers": [], "additional_components": [ "FBgn0266411", "FBgn0266411" ] }, "reaction_10458148": { "compartment": "compartment_7660", "id": "reaction_10458148", "reactome": "R-DME-1234171", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458083", "species_10458122" ], "products": [ "species_10458124" ], "modifiers": [], "additional_components": [ "FBgn0266411", "FBgn0264075", "O15945", "FBgn0264075", "Q24167", "FBgn0266411" ] }, "reaction_10458130": { "compartment": "compartment_7660", "id": "reaction_10458130", "reactome": "R-DME-1234167", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447242", "species_29428", "species_10458124", "species_10458126" ], "products": [ "species_10458128" ], "modifiers": [], "additional_components": [ "FBgn0261617", "O15945", "FBgn0264075", "Q24167", "FBgn0266411", "FBgn0261617", "M9MS40", "FBgn0261617", "O15945", "FBgn0264075", "Q24167", "FBgn0266411" ] }, "reaction_10443099": { "compartment": "compartment_70101", "id": "reaction_10443099", "reactome": "R-DME-210977", "name": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10443096", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "Q5BIB8", "FBgn0087011", "Q4V4U2", "FBgn0050280", "P26675", "Sos" ] }, "reaction_10467110": { "compartment": "compartment_876", "id": "reaction_10467110", "reactome": "R-DME-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467106", "species_10467101" ], "products": [ "species_10467108" ], "modifiers": [], "additional_components": [ "FBgn0264561", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "M9PIG4", "FBgn0264561" ] }, "reaction_10464490": { "compartment": "compartment_876", "id": "reaction_10464490", "reactome": "R-DME-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10464487", "catalyst" ] ], "additional_components": [ "B7YZT5", "FBgn0286511" ] }, "reaction_10464470": { "compartment": "compartment_876", "id": "reaction_10464470", "reactome": "R-DME-2029468", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_29372", "species_112275" ], "modifiers": [ [ "species_10464465", "catalyst" ] ], "additional_components": [ "FBgn0037341" ] }, "reaction_10464499": { "compartment": "compartment_876", "id": "reaction_10464499", "reactome": "R-DME-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10467643": { "compartment": "compartment_7660", "id": "reaction_10467643", "reactome": "R-DME-3215385", "name": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467633" ], "products": [ "species_10467640" ], "modifiers": [ [ "species_10467633", "catalyst" ] ], "additional_components": [ "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10467720": { "compartment": "compartment_7660", "id": "reaction_10467720", "reactome": "R-DME-3215448", "name": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467716", "species_10467638" ], "products": [ "species_10467718" ], "modifiers": [], "additional_components": [ "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715" ] }, "reaction_10467650": { "compartment": "compartment_7660", "id": "reaction_10467650", "reactome": "R-DME-3215406", "name": "PRMT5 binds WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467624", "species_10467629" ], "products": [ "species_10467631" ], "modifiers": [ [ "species_10467648", "inhibitor" ] ], "additional_components": [ "FBgn0003978", "FBgn0015925", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "FBgn0015925" ] }, "reaction_10467501": { "compartment": "compartment_7660", "id": "reaction_10467501", "reactome": "R-DME-3132737", "name": "MAPKs phosphorylate ETS1 and ETS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467496" ], "products": [ "species_113582", "species_10467499" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "FBgn0003118", "FBgn0003118", "P40417", "FBgn0003256" ] }, "reaction_10476303": { "compartment": "compartment_7660", "id": "reaction_10476303", "reactome": "R-DME-5682020", "name": "MRN complex binds shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432372", "species_3785706" ], "products": [ "species_10476301" ], "modifiers": [], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10481055": { "compartment": "compartment_7660", "id": "reaction_10481055", "reactome": "R-DME-6792712", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10481052" ], "products": [ "species_2485002", "species_10476309" ], "modifiers": [ [ "species_10481052", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080" ] }, "reaction_10454382": { "compartment": "compartment_876", "id": "reaction_10454382", "reactome": "R-DME-888589", "name": "Release of GABA at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454363", "species_74016" ], "products": [ "species_10443025", "species_10454369", "species_10442983", "species_10442919", "species_352003", "species_10454379", "species_10443021", "species_10442973", "species_10454365", "species_10454367", "species_10443023" ], "modifiers": [ [ "species_10454363", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "M9PE32", "FBgn0264606", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0266599", "FBgn0264606", "FBgn0004574", "P20228", "FBgn0004516", "species_74016", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0033911", "FBgn0004179", "FBgn0004242", "Q8IPM8", "FBgn0041605", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "M9PE32", "FBgn0264606", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343" ] }, "reaction_10455094": { "compartment": "compartment_917758", "id": "reaction_10455094", "reactome": "R-DME-917744", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10442919", "species_10442983", "species_10442968", "species_10454361", "species_10442973" ], "products": [ "species_10454363" ], "modifiers": [ [ "species_10454361", "catalyst" ] ], "additional_components": [ "FBgn0013343", "FBgn0004574", "FBgn0264606", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "FBgn0041605", "Q8IPM8", "FBgn0041605", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "M9PE32", "FBgn0264606", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516" ] }, "reaction_10454328": { "compartment": "compartment_70101", "id": "reaction_10454328", "reactome": "R-DME-888572", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10454325", "catalyst" ] ], "additional_components": [ "P20228", "FBgn0004516" ] }, "reaction_10454340": { "compartment": "compartment_917757", "id": "reaction_10454340", "reactome": "R-DME-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10454337", "catalyst" ] ], "additional_components": [ "P20228", "FBgn0004516" ] }, "reaction_10454385": { "compartment": "compartment_70101", "id": "reaction_10454385", "reactome": "R-DME-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10454349", "catalyst" ] ], "additional_components": [ "FBgn0033911" ] }, "reaction_10465871": { "compartment": "compartment_70101", "id": "reaction_10465871", "reactome": "R-DME-2465919", "name": "AWAT2 transfers PALM to 11cROL forming 11cRPALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431863", "species_200993" ], "products": [ "species_10465860", "species_76194" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927", "CHEBI:16254", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10465892": { "compartment": "compartment_70101", "id": "reaction_10465892", "reactome": "R-DME-2465971", "name": "RLBP1 binds atROL to form RLBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431861", "species_2473617" ], "products": [ "species_10465890" ], "modifiers": [], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_2473604", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289" ] }, "reaction_10465888": { "compartment": "compartment_70101", "id": "reaction_10465888", "reactome": "R-DME-2465940", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_2473607" ], "modifiers": [ [ "species_10465885", "catalyst" ] ], "additional_components": [ "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043" ] }, "reaction_10484702": { "compartment": "compartment_984", "id": "reaction_10484702", "reactome": "R-DME-6799959", "name": "PGLYRP3,4 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10484698" ], "products": [ "species_10484700" ], "modifiers": [ [ "species_158417", "catalyst" ] ], "additional_components": [ "Q9VYX7", "FBgn0030310", "Q9VYX7", "FBgn0030310", "species_6789198" ] }, "reaction_10485860": { "compartment": "compartment_984", "id": "reaction_10485860", "reactome": "R-DME-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485854" ], "products": [ "species_10485858" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "CHEBI:62643", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273", "CHEBI:62643", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273" ] }, "reaction_10489510": { "compartment": "compartment_984", "id": "reaction_10489510", "reactome": "R-DME-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10482357", "species_6789198" ], "products": [ "species_10489508" ], "modifiers": [], "additional_components": [ "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "species_6789198", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539" ] }, "reaction_10489513": { "compartment": "compartment_984", "id": "reaction_10489513", "reactome": "R-DME-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10489508" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10489508", "catalyst" ] ], "additional_components": [ "species_6789198", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "species_1236719", "CHEBI:21615", "species_6789198", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539" ] }, "reaction_10486923": { "compartment": "compartment_984", "id": "reaction_10486923", "reactome": "R-DME-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10486917" ], "products": [ "species_10486921" ], "modifiers": [], "additional_components": [ "FBgn0039527", "Q9VB21", "FBgn0039527", "species_6803081" ] }, "reaction_10484723": { "compartment": "compartment_984", "id": "reaction_10484723", "reactome": "R-DME-6799981", "name": "PGLYRP2 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10484716" ], "products": [ "species_10484718" ], "modifiers": [], "additional_components": [ "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "species_6789198" ] }, "reaction_10484721": { "compartment": "compartment_984", "id": "reaction_10484721", "reactome": "R-DME-6799977", "name": "PGLYRP2 hydrolyzes bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10484718" ], "products": [ "species_6799970", "species_10484716", "species_6799975" ], "modifiers": [ [ "species_10484716", "catalyst" ], [ "species_158417", "catalyst" ] ], "additional_components": [ "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "species_6789198", "CHEBI:28881", "species_1678743", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576" ] }, "reaction_10489521": { "compartment": "compartment_984", "id": "reaction_10489521", "reactome": "R-DME-8862771", "name": "PLA2G2A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8931784", "species_10460239" ], "products": [ "species_10489519" ], "modifiers": [], "additional_components": [ "CHEBI:62643", "species_74016", "Q8IML0", "FBgn0039655", "species_74016", "Q8IML0", "FBgn0039655", "CHEBI:62643" ] }, "reaction_10480075": { "compartment": "compartment_1222282", "id": "reaction_10480075", "reactome": "R-DME-6789072", "name": "PGLYRP1 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10480071" ], "products": [ "species_10480073" ], "modifiers": [ [ "species_1562550", "catalyst" ] ], "additional_components": [ "C0HK98", "FBgn0043576", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "Q9VYX7", "FBgn0030310", "C0HK98", "FBgn0043576", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "Q9VYX7", "FBgn0030310", "species_6789198" ] }, "reaction_10485878": { "compartment": "compartment_984", "id": "reaction_10485878", "reactome": "R-DME-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485852", "species_8931784" ], "products": [ "species_10485854" ], "modifiers": [], "additional_components": [ "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273", "CHEBI:62643", "CHEBI:62643", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273" ] }, "reaction_10485882": { "compartment": "compartment_984", "id": "reaction_10485882", "reactome": "R-DME-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485852", "species_6789198" ], "products": [ "species_10485880" ], "modifiers": [], "additional_components": [ "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273", "species_6789198", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273" ] }, "reaction_10457859": { "compartment": "compartment_1222282", "id": "reaction_10457859", "reactome": "R-DME-1222491", "name": "Lactoferrin scavenges iron ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2101051", "species_1222611", "species_10457855" ], "products": [ "species_10457857" ], "modifiers": [], "additional_components": [ "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "species_1222611", "species_2101051" ] }, "reaction_10467566": { "compartment": "compartment_70101", "id": "reaction_10467566", "reactome": "R-DME-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10467562" ], "products": [ "species_10467564" ], "modifiers": [], "additional_components": [ "FBgn0020270", "Q9XYZ4", "FBgn0020270", "species_874088" ] }, "reaction_10467514": { "compartment": "compartment_70101", "id": "reaction_10467514", "reactome": "R-DME-3134914", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467512" ], "products": [ "species_10467510" ], "modifiers": [], "additional_components": [] }, "reaction_10458430": { "compartment": "compartment_70101", "id": "reaction_10458430", "reactome": "R-DME-1250264", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_10458426" ], "products": [ "species_10458428" ], "modifiers": [], "additional_components": [ "FBgn0040070", "Q9VGU4", "FBgn0037856", "A8JQV1", "FBgn0042105", "Q9I7L1", "FBgn0042104", "Q9VI53", "FBgn0037465", "Q9I7L0", "FBgn0042102", "Q9VI00", "FBgn0037518", "Q9I7K8", "FBgn0042103", "Q9VHZ9", "FBgn0037519", "Q9I7K7", "FBgn0042101", "Q9VHZ8", "FBgn0037520", "Q8SYU5", "FBgn0037517", "Q9VGU7", "FBgn0037853", "Q0E8K8", "FBgn0035103", "Q9VGU4", "FBgn0037856", "A8JQV1", "FBgn0042105", "Q9I7L1", "FBgn0042104", "Q9VI53", "FBgn0037465", "Q9I7L0", "FBgn0042102", "Q9VI00", "FBgn0037518", "Q9I7K8", "FBgn0042103", "Q9VHZ9", "FBgn0037519", "Q9I7K7", "FBgn0042101", "Q9VHZ8", "FBgn0037520", "Q8SYU5", "FBgn0037517", "Q9VGU7", "FBgn0037853", "Q0E8K8", "FBgn0035103", "Q9V429", "FBgn0040070" ] }, "reaction_10458432": { "compartment": "compartment_70101", "id": "reaction_10458432", "reactome": "R-DME-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_1250243" ], "products": [ "species_10430994" ], "modifiers": [], "additional_components": [ "FBgn0040070", "FBgn0040070" ] }, "reaction_10464323": { "compartment": "compartment_70101", "id": "reaction_10464323", "reactome": "R-DME-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10446525" ], "products": [ "species_29370", "species_10447061", "species_10446509" ], "modifiers": [ [ "species_10446511", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698" ] }, "reaction_10437523": { "compartment": "compartment_984", "id": "reaction_10437523", "reactome": "R-DME-168947", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_168948", "species_10437517" ], "products": [ "species_10437521" ], "modifiers": [], "additional_components": [ "FBgn0036978", "Q9VPH1", "FBgn0036978" ] }, "reaction_10485986": { "compartment": "compartment_984", "id": "reaction_10485986", "reactome": "R-DME-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485978", "species_166005" ], "products": [ "species_10485984" ], "modifiers": [], "additional_components": [ "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979", "species_6803081", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979" ] }, "reaction_10486230": { "compartment": "compartment_984", "id": "reaction_10486230", "reactome": "R-DME-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443916" ], "products": [ "species_10485978" ], "modifiers": [], "additional_components": [ "E1JIT5", "FBgn0038979", "Q9VCZ5", "FBgn0038978", "Q24537", "Dsp1", "Q05783", "FBgn0004362", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979" ] }, "reaction_10485982": { "compartment": "compartment_984", "id": "reaction_10485982", "reactome": "R-DME-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485978", "species_181015" ], "products": [ "species_10485980" ], "modifiers": [], "additional_components": [ "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979", "species_181015", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979" ] }, "reaction_10434118": { "compartment": "compartment_7660", "id": "reaction_10434118", "reactome": "R-DME-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433259", "species_10433230" ], "products": [ "species_10434112" ], "modifiers": [], "additional_components": [ "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554" ] }, "reaction_390141": { "compartment": "compartment_70101", "id": "reaction_390141", "reactome": "R-DME-390141", "name": "D inhibits WTS", "reversible": "false", "notes": "In the absence of the transmembrane cadherin Fat (FT), the unconventional myosin Dachs (D) accumulates at the plasma membrane where it has access to and inhibits Warts (WTS) kinase.", "reactants": [ "species_390026", "species_390037" ], "products": [ "species_451889", "species_390037" ], "modifiers": [], "additional_components": [ "FBgn0000411", "FBgn0000411" ] }, "reaction_10495859": { "compartment": "compartment_7660", "id": "reaction_10495859", "reactome": "R-DME-9007926", "name": "ATRX binds DAXX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495855", "species_10467725" ], "products": [ "species_10495857" ], "modifiers": [], "additional_components": [ "FBgn0026573", "FBgn0031820", "Q9VMD0", "FBgn0031820", "A1Z8R2", "FBgn0026573" ] }, "reaction_10435134": { "compartment": "compartment_984", "id": "reaction_10435134", "reactome": "R-DME-140769", "name": "factor VII -> factor VIIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435117" ], "products": [ "species_10435131" ], "modifiers": [ [ "species_10435079", "catalyst" ] ], "additional_components": [ "species_74016", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016" ] }, "reaction_350400": { "compartment": "compartment_70101", "id": "reaction_350400", "reactome": "R-DME-350400", "name": "PK binds to DSH", "reversible": "false", "notes": "The PET/LIM domain of Prickle (PK) interacts with DEP domain and C-terminus of Dishevelled (DSH). The DEP domain is required by DSH for membrane localisation. Binding of Diego (DGO) and PK to DSH is mutually exclusive. PK binding to DSH prevents FZ PCP signalling.", "reactants": [ "species_351050", "species_205749" ], "products": [ "species_351069" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "A1Z6W3", "PK" ] }, "reaction_350403": { "compartment": "compartment_70101", "id": "reaction_350403", "reactome": "R-DME-350403", "name": "DGO binds to PK", "reversible": "false", "notes": "In the cytosol, Diego (DGO) can bind to Prickle (PK). This may result in there being less DGO to bind to and stabilise the Frizzled (FZ):Dishevelled (DSH) complex.", "reactants": [ "species_351050", "species_351073" ], "products": [ "species_351093" ], "modifiers": [], "additional_components": [ "Q7JUF2", "DGO", "A1Z6W3", "PK" ] }, "reaction_10445880": { "compartment": "compartment_876", "id": "reaction_10445880", "reactome": "R-DME-380905", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445872", "species_10445808", "species_10442978", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10445874" ], "modifiers": [ [ "species_10445872", "catalyst" ] ], "additional_components": [ "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0013343", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964" ] }, "reaction_10445877": { "compartment": "compartment_984", "id": "reaction_10445877", "reactome": "R-DME-380901", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445874" ], "products": [ "species_10445808", "species_10443025", "species_114523", "species_10442919", "species_10444855", "species_10443003", "species_10443019", "species_10442973", "species_10443023" ], "modifiers": [ [ "species_10445874", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0005586", "FBgn0004574", "FBgn0260964", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964" ] }, "reaction_10445844": { "compartment": "compartment_374932", "id": "reaction_10445844", "reactome": "R-DME-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10444368", "catalyst" ] ], "additional_components": [ "FBgn0260964" ] }, "reaction_10445870": { "compartment": "compartment_984", "id": "reaction_10445870", "reactome": "R-DME-380869", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445810" ], "products": [ "species_10445808", "species_10443025", "species_380873", "species_10444855", "species_10442919", "species_10443003", "species_10443019", "species_10442973", "species_10443023" ], "modifiers": [ [ "species_10445810", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0260964", "FBgn0004574", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343" ] }, "reaction_10471622": { "compartment": "compartment_70101", "id": "reaction_10471622", "reactome": "R-DME-5336443", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445828", "species_10445833", "species_10445823" ], "products": [ "species_10445839" ], "modifiers": [], "additional_components": [ "FBgn0013759", "FBgn0039269", "X2JE74", "FBgn0026313", "Q9W2S5", "FBgn0052677", "X2JE74", "FBgn0026313", "Q9W2S5", "FBgn0052677", "Q8IMT8", "FBgn0039269", "Q24210", "FBgn0013759" ] }, "reaction_10445841": { "compartment": "compartment_70101", "id": "reaction_10445841", "reactome": "R-DME-380574", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445808", "species_10442978", "species_10445797", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10445810" ], "modifiers": [ [ "species_10445797", "catalyst" ], [ "species_10445839", "catalyst" ] ], "additional_components": [ "FBgn0013343", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "X2JE74", "FBgn0026313", "Q9W2S5", "FBgn0052677", "Q8IMT8", "FBgn0039269", "Q24210", "FBgn0013759" ] }, "reaction_10442917": { "compartment": "compartment_984", "id": "reaction_10442917", "reactome": "R-DME-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10442914", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "Q9VRE6", "FBgn0064123", "M9PD84", "FBgn0259822", "P91645", "FBgn0263111" ] }, "reaction_10453885": { "compartment": "compartment_984", "id": "reaction_10453885", "reactome": "R-DME-629596", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10453878", "species_372533" ], "products": [ "species_10453880" ], "modifiers": [], "additional_components": [ "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "P25162", "FBgn0004118", "P17644", "FBgn0000039", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "A0A0S0WNY8", "FBgn0266347", "Q9W3G6", "FBgn0015519", "A0A499GGQ3", "FBgn0028875", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "P25162", "FBgn0004118", "P17644", "FBgn0000039", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "A0A0S0WNY8", "FBgn0266347", "Q9W3G6", "FBgn0015519", "A0A499GGQ3", "FBgn0028875", "species_372533" ] }, "reaction_10453883": { "compartment": "compartment_70101", "id": "reaction_10453883", "reactome": "R-DME-629595", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10453880", "catalyst" ] ], "additional_components": [ "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "P25162", "FBgn0004118", "P17644", "FBgn0000039", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "A0A0S0WNY8", "FBgn0266347", "Q9W3G6", "FBgn0015519", "A0A499GGQ3", "FBgn0028875", "species_372533" ] }, "reaction_10453827": { "compartment": "compartment_984", "id": "reaction_10453827", "reactome": "R-DME-629588", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10453820", "species_372533" ], "products": [ "species_10453822" ], "modifiers": [], "additional_components": [ "P09478", "FBgn0000036", "P04755", "FBgn0000038", "P25162", "FBgn0004118", "Q9W3G6", "FBgn0015519", "A0A0S0WNY8", "FBgn0266347", "P17644", "FBgn0000039", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "species_372533", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "P25162", "FBgn0004118", "Q9W3G6", "FBgn0015519", "A0A0S0WNY8", "FBgn0266347", "P17644", "FBgn0000039", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261" ] }, "reaction_10453825": { "compartment": "compartment_876", "id": "reaction_10453825", "reactome": "R-DME-622325", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10453822", "catalyst" ] ], "additional_components": [ "species_372533", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "P25162", "FBgn0004118", "Q9W3G6", "FBgn0015519", "A0A0S0WNY8", "FBgn0266347", "P17644", "FBgn0000039", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261" ] }, "reaction_10455728": { "compartment": "compartment_876", "id": "reaction_10455728", "reactome": "R-DME-975389", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10455725", "catalyst" ] ], "additional_components": [ "Q9W4G1", "FBgn0029733", "Q9VVH4", "FBgn0036727", "Q9V9Y4", "FBgn0039840", "Q94900", "FBgn0024963", "M9PI70", "FBgn0264908", "species_29424" ] }, "reaction_350444": { "compartment": "compartment_70101", "id": "reaction_350444", "reactome": "R-DME-350444", "name": "ROK phosphorylates SQH", "reversible": "false", "notes": "Myosin regulatory light chain (MRLC) orthologue Spaghetti Squash (SQH) is phosphorylated at Thr20 and Ser21 by Rho-kinase (ROK). Zipper (ZIP) the myosin heavy chain orthologue would be expected to have its conformation modified and catalytic ativity elevated upon SQH phosphorylation. This leads to cytoskeletal organisation and correct pre-hair orientation.", "reactants": [ "species_113592", "species_351068" ], "products": [ "species_351002", "species_29370" ], "modifiers": [ [ "species_450785", "catalyst" ] ], "additional_components": [ "Q99323", "zip", "P40423", "phospho-sqh", "P54357", "Mlc-c", "Q99323", "zip", "P54357", "Mlc-c", "P40423", "phospho-sqh", "Q9U779", "ROK", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_350362": { "compartment": "compartment_70101", "id": "reaction_350362", "reactome": "R-DME-350362", "name": "ROK phosphorylates MBS", "reversible": "false", "notes": "Myosin binding subunit (MBS) of Myosin phosphatase is phosphorylated at Thr594 by activated Rho-kinase (ROK). Myosin phosphatase is subsequently deactivated.", "reactants": [ "species_351071", "species_113592" ], "products": [ "species_29370", "species_351077" ], "modifiers": [ [ "species_450785", "catalyst" ] ], "additional_components": [ "P48462", "flw", "P12982", "PP1-87B", "Q8IQN4", "Phospho MBS", "P48462", "flw", "P12982", "PP1-87B", "Q8IQN4", "Phospho MBS", "Q9U779", "ROK", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_10455221": { "compartment": "compartment_70101", "id": "reaction_10455221", "reactome": "R-DME-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455216", "species_113592" ], "products": [ "species_10455218", "species_29370" ], "modifiers": [ [ "species_10455216", "catalyst" ] ], "additional_components": [ "O46080", "FBgn0023520", "Q9VKQ6", "FBgn0032296", "Q9VYS3", "FBgn0030354", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "O46080", "FBgn0023520", "Q9VKQ6", "FBgn0032296", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VYS3", "FBgn0030354", "O46080", "FBgn0023520", "Q9VKQ6", "FBgn0032296", "Q9VYS3", "FBgn0030354", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10455200": { "compartment": "compartment_70101", "id": "reaction_10455200", "reactome": "R-DME-927836", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455197" ], "products": [ "species_10455182" ], "modifiers": [ [ "species_10455197", "catalyst" ] ], "additional_components": [ "Q9V414", "FBgn0019890", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VYS3", "FBgn0030354", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q9VBZ6", "FBgn0039260", "P21187", "FBgn0265297", "Q9V414", "FBgn0019890", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q9VYS3", "FBgn0030354", "Q9VBZ6", "FBgn0039260", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9V414", "FBgn0019890", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VYS3", "FBgn0030354", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q9VBZ6", "FBgn0039260" ] }, "reaction_10455156": { "compartment": "compartment_70101", "id": "reaction_10455156", "reactome": "R-DME-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455152", "species_10455132" ], "products": [ "species_10455154" ], "modifiers": [], "additional_components": [ "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VK85", "FBgn0020443", "species_29420", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "FBgn0030354", "Q9VYS3", "FBgn0030354", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VK85", "FBgn0020443", "species_29420", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974" ] }, "reaction_10429278": { "compartment": "compartment_7660", "id": "reaction_10429278", "reactome": "R-DME-72095", "name": "Internal Methylation of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429250" ], "products": [ "species_10429258" ], "modifiers": [ [ "species_10429275", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCE6", "FBgn0039139", "Q9Y091", "FBgn0000662", "Q9VLP7", "FBgn0032016" ] }, "reaction_10432074": { "compartment": "compartment_7660", "id": "reaction_10432074", "reactome": "R-DME-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432068" ], "products": [ "species_10432068" ], "modifiers": [], "additional_components": [ "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587" ] }, "reaction_10432072": { "compartment": "compartment_7660", "id": "reaction_10432072", "reactome": "R-DME-75081", "name": "Formation of AT-AC B Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432064", "species_10432054" ], "products": [ "species_10432066" ], "modifiers": [], "additional_components": [ "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786" ] }, "reaction_10432070": { "compartment": "compartment_7660", "id": "reaction_10432070", "reactome": "R-DME-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432066" ], "products": [ "species_10432068", "species_10432058" ], "modifiers": [], "additional_components": [ "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426" ] }, "reaction_10449034": { "compartment": "compartment_70101", "id": "reaction_10449034", "reactome": "R-DME-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448979", "species_429974" ], "products": [ "species_10448981" ], "modifiers": [], "additional_components": [ "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067", "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067" ] }, "reaction_10449015": { "compartment": "compartment_70101", "id": "reaction_10449015", "reactome": "R-DME-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10448981" ], "products": [ "species_10448983", "species_430004" ], "modifiers": [ [ "species_10449012", "catalyst" ] ], "additional_components": [ "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067", "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067", "Q9VKK1", "FBgn0283682", "Q9VVI2", "FBgn0036735", "Q5U127", "FBgn0036534", "Q9W1H5", "FBgn0034921", "P23128", "FBgn0004419" ] }, "reaction_10470317": { "compartment": "compartment_7660", "id": "reaction_10470317", "reactome": "R-DME-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10468620" ], "products": [ "species_113582", "species_10470281" ], "modifiers": [ [ "species_10470314", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "P22813", "FBgn0001222", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691" ] }, "reaction_10470283": { "compartment": "compartment_7660", "id": "reaction_10470283", "reactome": "R-DME-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470233" ], "products": [ "species_10470271" ], "modifiers": [ [ "species_10470276", "catalyst" ], [ "species_10470281", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "P02517", "FBgn0001225", "P22979", "FBgn0001229", "P02516", "FBgn0001224", "P05812", "FBgn0001227", "P02515", "FBgn0001223", "P02518", "FBgn0001226", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "P02828", "FBgn0001233", "Q9VK90", "FBgn0032429", "P11147", "FBgn0266599", "P22813", "FBgn0001222", "P22813", "FBgn0001222" ] }, "reaction_10470298": { "compartment": "compartment_7660", "id": "reaction_10470298", "reactome": "R-DME-5082387", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10468620" ], "products": [ "species_113582", "species_10470276" ], "modifiers": [ [ "species_10470295", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "P22813", "FBgn0001222", "Q00168", "FBgn0264607" ] }, "reaction_10468622": { "compartment": "compartment_70101", "id": "reaction_10468622", "reactome": "R-DME-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468616" ], "products": [ "species_10468620" ], "modifiers": [ [ "species_10432016", "inhibitor" ] ], "additional_components": [ "P22813", "FBgn0001222", "P22813", "FBgn0001222", "P92177", "14-3-3epsilon" ] }, "reaction_10470302": { "compartment": "compartment_7660", "id": "reaction_10470302", "reactome": "R-DME-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470300" ], "products": [ "species_10468620" ], "modifiers": [], "additional_components": [ "FBgn0001222", "P22813", "FBgn0001222" ] }, "reaction_10468653": { "compartment": "compartment_70101", "id": "reaction_10468653", "reactome": "R-DME-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468527" ], "products": [ "species_10468616" ], "modifiers": [ [ "species_10435578", "catalyst" ] ], "additional_components": [ "FBgn0001222", "P22813", "FBgn0001222", "P08736", "FBgn0284245", "P05303", "FBgn0000557" ] }, "reaction_10470329": { "compartment": "compartment_7660", "id": "reaction_10470329", "reactome": "R-DME-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470327" ], "products": [ "species_10470325", "species_10470300", "species_10470319" ], "modifiers": [], "additional_components": [ "Q9VH95", "FBgn0037728", "P22813", "FBgn0001222", "P02828", "FBgn0001233", "P02828", "FBgn0001233", "FBgn0001222", "FBgn0037728" ] }, "reaction_10468645": { "compartment": "compartment_70101", "id": "reaction_10468645", "reactome": "R-DME-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468643" ], "products": [ "species_10443622", "species_10468604", "species_10468527" ], "modifiers": [], "additional_components": [ "P22813", "FBgn0001222", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "FBgn0037728", "P02828", "FBgn0001233", "FBgn0001222" ] }, "reaction_10471524": { "compartment": "compartment_70101", "id": "reaction_10471524", "reactome": "R-DME-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10471519" ], "products": [ "species_10471521", "species_10443622", "species_10468604", "species_10468527" ], "modifiers": [ [ "species_10471519", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "Q7KN62", "FBgn0286784", "P02828", "FBgn0001233", "M9PJN5", "FBgn0026428", "Q9VH95", "FBgn0037728", "Q7KN62", "FBgn0286784", "M9PJN5", "FBgn0026428", "FBgn0037728", "P02828", "FBgn0001233", "FBgn0001222", "P22813", "FBgn0001222", "Q7KN62", "FBgn0286784", "P02828", "FBgn0001233", "M9PJN5", "FBgn0026428", "Q9VH95", "FBgn0037728" ] }, "reaction_350441": { "compartment": "compartment_70101", "id": "reaction_350441", "reactome": "R-DME-350441", "name": "FLW:MYPT-75D complex dephosphorylates SQH", "reversible": "false", "notes": "Flap wing (FLW) complexed with MYPT-75D dephosphorylates Spaghetti Squash (SQH).", "reactants": [ "species_351064" ], "products": [ "species_29372", "species_351041" ], "modifiers": [ [ "species_351025", "catalyst" ] ], "additional_components": [ "Q8SY34", "MYPT-75D", "P48462", "flw" ] }, "reaction_350475": { "compartment": "compartment_70101", "id": "reaction_350475", "reactome": "R-DME-350475", "name": "FLW:MBS complex dephosphorylates SQH", "reversible": "false", "notes": "Flap wing (FLW) complexed with Myosin binding subunit (MBS) dephosphorylates Spaghetti Squash (SQH).", "reactants": [ "species_351064" ], "products": [ "species_29372", "species_351041" ], "modifiers": [ [ "species_350944", "catalyst" ] ], "additional_components": [ "Q8IQN4", "Phospho MBS", "P48462", "flw" ] }, "reaction_350443": { "compartment": "compartment_70101", "id": "reaction_350443", "reactome": "R-DME-350443", "name": "PP1-87B:MBS complex dephosphorylates SQH", "reversible": "false", "notes": "PP1-87B complexed with Myosin binding subunit (MBS) dephosphorylates Spaghetti Squash (SQH).", "reactants": [ "species_351064" ], "products": [ "species_29372", "species_351041" ], "modifiers": [ [ "species_350963", "catalyst" ] ], "additional_components": [ "Q8IQN4", "Phospho MBS", "P12982", "PP1-87B" ] }, "reaction_450741": { "compartment": "compartment_876", "id": "reaction_450741", "reactome": "R-DME-450741", "name": "VANG, IN, FY, and FRTZ colocalise at the plasma membrane", "reversible": "false", "notes": "In the wing, Van Gogh (VANG) aka Strabismus (Stbm), Inturned (IN), Fuzzy (FY), and Fritz (FRTZ) all colocalise to the proximal side of the plasma membrane.", "reactants": [ "species_450782", "species_450734", "species_450722", "species_450756" ], "products": [ "species_450782", "species_450734", "species_450722", "species_450756" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK" ] }, "reaction_450770": { "compartment": "compartment_70101", "id": "reaction_450770", "reactome": "R-DME-450770", "name": "MWH binds to RHO1:GTP and is activated", "reversible": "false", "notes": "In the wing, autoinhibited multiple wing hairs (MWH) protein via its GTPase binding domain (GBD) binds to activated RHO1:GTP at the proximal side of the plasma membrane. This relieves the inhibition in MWH and it is now activated. The previously blocked dimerisation domain (DD) is now exposed and able to bind to other formins in a dominant negative manner. The sequestered formins are now unable to promote actin polymerisation around the proximal edge of the cell. It is postulated that the MWH:formin complexes which form in proximity to the developing hair at the distal edge inhibit formation of secondary hairs. There is evidence in the literature that MWH is also phosphorylated by an unknown kinase but definitive proof that this is important for its activity is currently undetermined (Strutt and Warrington, 2008).", "reactants": [ "species_350950", "species_450759" ], "products": [ "species_450755" ], "modifiers": [], "additional_components": [ "species_29438", "P48148", "Rho1", "Q9W0J2", "MWH", "species_29438", "P48148", "Rho1" ] }, "reaction_450802": { "compartment": "compartment_876", "id": "reaction_450802", "reactome": "R-DME-450802", "name": "FZ and VANG bind to STAN homodimer", "reversible": "false", "notes": "The seven-pass transmembrane protein Frizzled (FZ) and the four-pass transmembrane protein Van Gogh (VANG) aka Strabismus (Stbm) bind to opposite ends of the seven-pass transmembrane atypical cadherin Starry Night (STAN) aka Flamingo homodimer. In the case of VANG, this interaction is to the C-terminal domain of STAN. Additionally, there's a possibility of a direct interaction between FZ and VANG.", "reactants": [ "species_205850", "species_351026", "species_351126" ], "products": [ "species_450698" ], "modifiers": [], "additional_components": [ "Q9V5N8", "STAN", "O45030", "VANG", "Q9V5N8", "STAN", "P18537", "FZ" ] }, "reaction_350467": { "compartment": "compartment_70101", "id": "reaction_350467", "reactome": "R-DME-350467", "name": "GUG binds to FT", "reversible": "false", "notes": "The transcriptional repressor Grunge (GUG) aka Atro binds to the intracellular domain of Fat (FT) reinforcing the corresponding strong genetic interaction evidence. GUG like FT is specifically required in the R3 photoreceptor.", "reactants": [ "species_350975", "species_350966" ], "products": [ "species_350926" ], "modifiers": [], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS", "P33450", "Phospho FT", "Q24292", "DS", "Q9NHX6", "GUG" ] }, "reaction_350377": { "compartment": "compartment_876", "id": "reaction_350377", "reactome": "R-DME-350377", "name": "Extracellular domains of STAN bind to each other in adjacent cells", "reversible": "false", "notes": "The seven-pass transmembrane atypical cadherin Starry Night (STAN) aka Flamingo is known to mediate homophilic protein-protein interaction.", "reactants": [ "species_350928" ], "products": [ "species_351026" ], "modifiers": [], "additional_components": [ "Q9V5N8", "STAN" ] }, "reaction_10441901": { "compartment": "compartment_876", "id": "reaction_10441901", "reactome": "R-DME-202222", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441891", "species_113592" ], "products": [ "species_29370", "species_10441898" ], "modifiers": [ [ "species_10441882", "catalyst" ] ], "additional_components": [ "species_112275", "P83099", "FBgn0259680", "species_112275", "P83099", "FBgn0259680", "species_202247", "species_179838", "Q9W0V1", "Pdk1" ] }, "reaction_10441919": { "compartment": "compartment_70101", "id": "reaction_10441919", "reactome": "R-DME-202354", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441912", "species_179856" ], "products": [ "species_10441917" ], "modifiers": [], "additional_components": [ "FBgn0003416", "species_179856", "Q9VXH3", "FBgn0003416" ] }, "reaction_10441932": { "compartment": "compartment_70101", "id": "reaction_10441932", "reactome": "R-DME-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10441929", "catalyst" ] ], "additional_components": [ "FBgn0003416" ] }, "reaction_10447468": { "compartment": "compartment_70101", "id": "reaction_10447468", "reactome": "R-DME-418158", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447466" ], "products": [ "species_10447466" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733" ] }, "reaction_10447489": { "compartment": "compartment_70101", "id": "reaction_10447489", "reactome": "R-DME-418200", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447487" ], "products": [ "species_10447487" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P00528", "FBgn0262733" ] }, "reaction_10447473": { "compartment": "compartment_70101", "id": "reaction_10447473", "reactome": "R-DME-418163", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447466" ], "products": [ "species_10447470" ], "modifiers": [ [ "species_10447466", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733" ] }, "reaction_10449789": { "compartment": "compartment_70101", "id": "reaction_10449789", "reactome": "R-DME-442314", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449781" ], "products": [ "species_29420", "species_10449783" ], "modifiers": [ [ "species_10449786", "catalyst" ] ], "additional_components": [ "species_29420", "P40792", "RAC1_DROME", "P48148", "Rho1", "P40792", "RAC1_DROME", "P48148", "Rho1", "species_29438", "FBgn0040068" ] }, "reaction_10435017": { "compartment": "compartment_70101", "id": "reaction_10435017", "reactome": "R-DME-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10435014", "catalyst" ] ], "additional_components": [ "FBgn0003416" ] }, "reaction_10449704": { "compartment": "compartment_70101", "id": "reaction_10449704", "reactome": "R-DME-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10431820", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10448868": { "compartment": "compartment_876", "id": "reaction_10448868", "reactome": "R-DME-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448866" ], "products": [ "species_10435014" ], "modifiers": [], "additional_components": [ "FBgn0003416", "FBgn0003416" ] }, "reaction_10449763": { "compartment": "compartment_70101", "id": "reaction_10449763", "reactome": "R-DME-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449751" ], "products": [ "species_29420", "species_10449753" ], "modifiers": [ [ "species_10449756", "catalyst" ], [ "species_10449761", "catalyst" ], [ "species_10449759", "inhibitor" ] ], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29420", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "FBgn0040068", "Q9NHV9", "FBgn0040068", "species_179838", "species_179856", "Q9NHV9", "FBgn0040068" ] }, "reaction_10449777": { "compartment": "compartment_70101", "id": "reaction_10449777", "reactome": "R-DME-442291", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449769" ], "products": [ "species_29420", "species_10449771" ], "modifiers": [ [ "species_10449774", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "FBgn0040068" ] }, "reaction_10446140": { "compartment": "compartment_876", "id": "reaction_10446140", "reactome": "R-DME-381750", "name": "Olfactory Receptor - G Protein olfactory trimer complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446099", "species_10446067" ], "products": [ "species_10446101" ], "modifiers": [ [ "species_10446138", "catalyst" ] ], "additional_components": [ "Q4LBB9", "FBgn0038063", "P41596", "FBgn0011582", "Q9NFZ3", "FBgn0267252", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "P26308", "FBgn0001105", "Q4LBB9", "FBgn0038063", "P41596", "FBgn0011582", "Q9NFZ3", "FBgn0267252", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "P26308", "FBgn0001105", "Q9W1J5", "FBgn0034907" ] }, "reaction_10446069": { "compartment": "compartment_876", "id": "reaction_10446069", "reactome": "R-DME-381749", "name": "G Protein trimer formation (olfactory)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437306", "species_10437738", "species_10434556" ], "products": [ "species_10446067" ], "modifiers": [], "additional_components": [ "FBgn0001105", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "FBgn0267252", "Q9NFZ3", "FBgn0267252", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "P26308", "FBgn0001105" ] }, "reaction_10465838": { "compartment": "compartment_70101", "id": "reaction_10465838", "reactome": "R-DME-2453833", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2864099" ], "products": [ "species_30927", "species_2864103", "species_70106" ], "modifiers": [ [ "species_10465830", "catalyst" ], [ "species_10465836", "catalyst" ] ], "additional_components": [ "CHEBI:70762", "species_2534407", "CHEBI:70760", "CHEBI:70761", "CHEBI:16196", "CHEBI:17351", "species_3632881", "species_8934421", "FBgn0002937", "FBgn0000317" ] }, "reaction_10465854": { "compartment": "compartment_70101", "id": "reaction_10465854", "reactome": "R-DME-2454264", "name": "11cROL binds to RLBP1 to form RLBP1:11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30927", "species_10431861" ], "products": [ "species_10431863" ], "modifiers": [], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927" ] }, "reaction_10431900": { "compartment": "compartment_12045", "id": "reaction_10431900", "reactome": "R-DME-74872", "name": "RDH10,11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431863", "species_29366" ], "products": [ "species_70106", "species_10431865", "species_29364" ], "modifiers": [ [ "species_10431897", "catalyst" ] ], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927", "species_8960974", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q9VCR9", "FBgn0039043", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9W3K9", "FBgn0029994", "Q9VCS2", "FBgn0039040", "Q9VR28", "FBgn0031630" ] }, "reaction_10465852": { "compartment": "compartment_12045", "id": "reaction_10465852", "reactome": "R-DME-2454081", "name": "RDH5 oxidises 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431863", "species_29360" ], "products": [ "species_70106", "species_10431865", "species_73473" ], "modifiers": [ [ "species_10465841", "catalyst" ] ], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927", "species_8960974", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "FBgn0000056" ] }, "reaction_10495347": { "compartment": "compartment_70101", "id": "reaction_10495347", "reactome": "R-DME-8960973", "name": "RLBP1:11cRAL dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431865" ], "products": [ "species_10431861", "species_8960974" ], "modifiers": [], "additional_components": [ "species_8960974", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289" ] }, "reaction_10431849": { "compartment": "compartment_70101", "id": "reaction_10431849", "reactome": "R-DME-74843", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431845", "species_2473604" ], "products": [ "species_10431847" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_2473604", "Q8INK3", "FBgn0037913" ] } }, "motif_reaction_dictionary": { "reaction_10497653": { "compartment": "compartment_70101", "id": "reaction_10497653", "reactome": "R-DME-9619376", "name": "CAMK1 binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10497649" ], "products": [ "species_10497651" ], "modifiers": [], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "FBgn0016126", "Q7JMV3", "FBgn0016126", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10435736": { "compartment": "compartment_70101", "id": "reaction_10435736", "reactome": "R-DME-159050", "name": "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435730", "species_10430485" ], "products": [ "species_10432289", "species_10435734", "species_10432313" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "Q9VAN6", "FBgn0041186", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "FBgn0003321", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VAN6", "FBgn0041186", "FBgn0010774", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10433271": { "compartment": "compartment_7660", "id": "reaction_10433271", "reactome": "R-DME-77587", "name": "Docking of Mature Replication Dependent Histone mRNA with the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433265", "species_10429500", "species_10432253" ], "products": [ "species_10433269", "species_10429162", "species_10429167" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "FBgn0010774", "FBgn0003321", "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9VAN6", "FBgn0041186", "FBgn0022943", "FBgn0022942", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435732": { "compartment": "compartment_13231", "id": "reaction_10435732", "reactome": "R-DME-159046", "name": "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433269" ], "products": [ "species_10435730" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9VAN6", "FBgn0041186", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "Q9VAN6", "FBgn0041186", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10470941": { "compartment": "compartment_876", "id": "reaction_10470941", "reactome": "R-DME-5218806", "name": "FYN autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470936" ], "products": [ "species_29370", "species_10470938" ], "modifiers": [ [ "species_10470936", "catalyst" ] ], "additional_components": [ "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "P00528", "FBgn0262733" ] }, "reaction_10471003": { "compartment": "compartment_876", "id": "reaction_10471003", "reactome": "R-DME-5218850", "name": "VAV exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10470998" ], "products": [ "species_29420", "species_10471000" ], "modifiers": [ [ "species_10470998", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29420", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29420" ] }, "reaction_10470975": { "compartment": "compartment_876", "id": "reaction_10470975", "reactome": "R-DME-5218821", "name": "PDK1 phosphorylates PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470972" ], "products": [ "species_29370", "species_10470910" ], "modifiers": [ [ "species_10433702", "catalyst" ] ], "additional_components": [ "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854", "P83099", "FBgn0259680", "A1Z9X0", "FBgn0261854", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091" ] }, "reaction_10470954": { "compartment": "compartment_70101", "id": "reaction_10470954", "reactome": "R-DME-5218813", "name": "DAG and Ca+2 bind to PKC and tether it to membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470931", "species_112275", "species_74016" ], "products": [ "species_10470952" ], "modifiers": [], "additional_components": [ "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854", "species_74016", "species_112275", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854" ] }, "reaction_10470934": { "compartment": "compartment_70101", "id": "reaction_10470934", "reactome": "R-DME-5218805", "name": "PKC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470910" ], "products": [ "species_10470931", "species_29370" ], "modifiers": [ [ "species_10470910", "catalyst" ] ], "additional_components": [ "A1Z9X0", "FBgn0261854", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854", "A1Z9X0", "FBgn0261854", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091" ] }, "reaction_10470981": { "compartment": "compartment_876", "id": "reaction_10470981", "reactome": "R-DME-5218823", "name": "PKC phosphorylates sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446693", "species_113592" ], "products": [ "species_10470978", "species_29370" ], "modifiers": [ [ "species_10470952", "catalyst" ] ], "additional_components": [ "FBgn0030300", "FBgn0030300", "species_74016", "species_112275", "P83099", "FBgn0259680", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "A1Z9X0", "FBgn0261854" ] }, "reaction_10470994": { "compartment": "compartment_70101", "id": "reaction_10470994", "reactome": "R-DME-5218845", "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470991" ], "products": [ "species_5218688", "species_10437909", "species_29370", "species_10439352" ], "modifiers": [ [ "species_10470978", "catalyst" ] ], "additional_components": [ "Q8IR23", "FBgn0003969", "species_1606609", "species_29438", "P08646", "RAS85D", "species_29438", "P08646", "RAS85D", "FBgn0003969", "FBgn0030300" ] }, "reaction_10441855": { "compartment": "compartment_70101", "id": "reaction_10441855", "reactome": "R-DME-202111", "name": "AKT1 phosphorylates eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441844", "species_113592" ], "products": [ "species_29370", "species_10441853" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "species_74016", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10440781": { "compartment": "compartment_70101", "id": "reaction_10440781", "reactome": "R-DME-198270", "name": "PDPK1 phosphorylates AKT at T308", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440773", "species_113592" ], "products": [ "species_29370", "species_10440775", "species_10433704" ], "modifiers": [ [ "species_10440773", "catalyst" ] ], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838", "Q8INB9", "phospho-Akt1", "Q9W0V1", "Pdk1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "Q8INB9", "phospho-Akt1" ] }, "reaction_10471692": { "compartment": "compartment_876", "id": "reaction_10471692", "reactome": "R-DME-5357472", "name": "PAK1-3 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471687" ], "products": [ "species_10447061", "species_29370", "species_10471000" ], "modifiers": [ [ "species_10446523", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10465531": { "compartment": "compartment_876", "id": "reaction_10465531", "reactome": "R-DME-2317314", "name": "AKT binds PDPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440771", "species_10433704" ], "products": [ "species_10440773" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "Q8INB9", "phospho-Akt1" ] }, "reaction_10471689": { "compartment": "compartment_876", "id": "reaction_10471689", "reactome": "R-DME-5357445", "name": "PAK1-3 dimer disassociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471685" ], "products": [ "species_10471687" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10471703": { "compartment": "compartment_876", "id": "reaction_10471703", "reactome": "R-DME-5357483", "name": "RAC1 binds PAK1-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471000", "species_10446523" ], "products": [ "species_10471685" ], "modifiers": [], "additional_components": [ "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10471701": { "compartment": "compartment_876", "id": "reaction_10471701", "reactome": "R-DME-5357477", "name": "PAK1-3 phosphorylates VE-cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471694" ], "products": [ "species_10471699", "species_29370" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q9VJB6", "FBgn0262018", "Q7PLI0", "FBgn0260799", "P18824", "arm", "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q7PLI0", "FBgn0260799", "Q9VJB6", "FBgn0262018", "P18824", "arm", "FBgn0267698" ] }, "reaction_10441860": { "compartment": "compartment_70101", "id": "reaction_10441860", "reactome": "R-DME-202127", "name": "eNOS synthesizes NO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10441857", "catalyst" ], [ "species_5693375", "inhibitor" ] ], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10465459": { "compartment": "compartment_70101", "id": "reaction_10465459", "reactome": "R-DME-2316429", "name": "PIP3 recruits PDPK1 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10441880" ], "products": [ "species_10433704" ], "modifiers": [], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10459875": { "compartment": "compartment_70101", "id": "reaction_10459875", "reactome": "R-DME-1497784", "name": "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_10441853" ], "products": [ "species_10441857" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10440881": { "compartment": "compartment_70101", "id": "reaction_10440881", "reactome": "R-DME-198640", "name": "TORC2 (mTOR) phosphorylates AKT at S473", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440860" ], "products": [ "species_10440771", "species_29370" ], "modifiers": [ [ "species_10440874", "catalyst" ], [ "species_10440879", "inhibitor" ] ], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "Q8INB9", "phospho-Akt1", "species_179838", "Q9VK45", "FBgn0021796", "Q9V719", "FBgn0033935", "Q9W328", "FBgn0264691", "Q9VWJ6", "FBgn0031006", "Q9V3Z1", "FBgn0028978", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10441872": { "compartment": "compartment_70101", "id": "reaction_10441872", "reactome": "R-DME-202137", "name": "AKT1 binds eNOS complex via HSP90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441840", "species_10440775" ], "products": [ "species_10441844" ], "modifiers": [], "additional_components": [ "P02828", "FBgn0001233", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "species_74016", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "species_74016" ] }, "reaction_10470966": { "compartment": "compartment_876", "id": "reaction_10470966", "reactome": "R-DME-5218819", "name": "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10470963", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10493673": { "compartment": "compartment_876", "id": "reaction_10493673", "reactome": "R-DME-8951586", "name": "p-VAV family:PIP3 binds RAC1:GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464321", "species_10470968" ], "products": [ "species_10470998" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "Q9NHV9", "FBgn0040068", "species_179838", "Q9NHV9", "FBgn0040068", "species_179838", "P40792", "RAC1_DROME", "species_29420" ] }, "reaction_10470996": { "compartment": "compartment_876", "id": "reaction_10470996", "reactome": "R-DME-5218847", "name": "PAK2 binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470880", "species_10446517" ], "products": [ "species_10470985" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10470961": { "compartment": "compartment_876", "id": "reaction_10470961", "reactome": "R-DME-5218814", "name": "PAK2 autophorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470958" ], "products": [ "species_10470947", "species_29370" ], "modifiers": [ [ "species_10470958", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10439437": { "compartment": "compartment_70101", "id": "reaction_10439437", "reactome": "R-DME-187688", "name": "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439409", "species_113592" ], "products": [ "species_29370", "species_10439416" ], "modifiers": [ [ "species_10439434", "catalyst" ] ], "additional_components": [ "FBgn0013987", "FBgn0013987", "species_29926", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765" ] }, "reaction_10471021": { "compartment": "compartment_70101", "id": "reaction_10471021", "reactome": "R-DME-5218916", "name": "p-MAPK2/3 phosphorylates HSP27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471014" ], "products": [ "species_10449184", "species_29370", "species_10471019" ], "modifiers": [ [ "species_10439416", "catalyst" ] ], "additional_components": [ "Q8IQW5", "FBgn0031037", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "FBgn0031037", "FBgn0013987" ] }, "reaction_10470892": { "compartment": "compartment_70101", "id": "reaction_10470892", "reactome": "R-DME-5218804", "name": "p38 MAPK activation by VEGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451571", "species_113592" ], "products": [ "species_29370", "species_10439434" ], "modifiers": [ [ "species_10470889", "catalyst" ] ], "additional_components": [ "species_29926", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "species_29926", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10470987": { "compartment": "compartment_876", "id": "reaction_10470987", "reactome": "R-DME-5218832", "name": "CDC42:GTP binds PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439139", "species_10470985" ], "products": [ "species_10470958" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "B7Z0W0", "FBgn0267698", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10469449": { "compartment": "compartment_876", "id": "reaction_10469449", "reactome": "R-DME-3928647", "name": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604", "species_10434906" ], "products": [ "species_10447647" ], "modifiers": [], "additional_components": [ "FBgn0026181", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181" ] }, "reaction_10464390": { "compartment": "compartment_876", "id": "reaction_10464390", "reactome": "R-DME-2029465", "name": "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067", "species_10464386", "species_10464339", "species_179838" ], "products": [ "species_10464388" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "FBgn0052082", "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10470950": { "compartment": "compartment_876", "id": "reaction_10470950", "reactome": "R-DME-5218812", "name": "FYN phosphorylates PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470947", "species_113592" ], "products": [ "species_29370", "species_10470889" ], "modifiers": [ [ "species_10470947", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10471107": { "compartment": "compartment_70101", "id": "reaction_10471107", "reactome": "R-DME-5228992", "name": "ROCK1,ROCK2 are activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447647" ], "products": [ "species_10471105" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181", "species_29926", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181" ] }, "reaction_10471008": { "compartment": "compartment_70101", "id": "reaction_10471008", "reactome": "R-DME-5218854", "name": "p-Y420-FYN is phosphorylated on S21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470938" ], "products": [ "species_10470880", "species_29370" ], "modifiers": [ [ "species_10471005", "catalyst" ] ], "additional_components": [ "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_209235": { "compartment": "compartment_13231", "id": "reaction_209235", "reactome": "R-DME-209235", "name": "Phosphorylated BSK kinase transports from the cytosol to the nucleus", "reversible": "false", "notes": "Free phosphorylated Basket (BSK) kinase is now able to translocate from the cytosol to the nucleus.", "reactants": [ "species_206213" ], "products": [ "species_206300" ], "modifiers": [], "additional_components": [] }, "reaction_209330": { "compartment": "compartment_7660", "id": "reaction_209330", "reactome": "R-DME-209330", "name": "Phosphorylated BSK kinase and the AP-1 transcription factor, JRA:KAY, bind to CKA scaffolding protein in the nucleus", "reversible": "false", "notes": "In the nucleus, another molecule of the scaffolding protein CKA binds the phosphorylated Basket (BSK) kinase and the AP-1 transcription factor heterodimer. The latter is made up of the c-Jun ortholgue, Jun-related antigen (JRA) and the c-Fos orthologue, Kayak (KAY).", "reactants": [ "species_206300", "species_205983", "species_206724" ], "products": [ "species_207020" ], "modifiers": [], "additional_components": [ "P21525", "phospho-kay", "P18289", "phospho-Jra", "P21525", "phospho-kay", "P18289", "phospho-Jra", "Q9VLT9", "CKA", "P92208", "bsk" ] }, "reaction_209381": { "compartment": "compartment_7660", "id": "reaction_209381", "reactome": "R-DME-209381", "name": "AP-1 transcription factor, JRA:KAY, is phosphorylated by phosphorylated BSK kinase", "reversible": "false", "notes": "Phosphorylated Basket (BSK) kinase phosphorylates residues Ser82 and Ser92 on JRA along with residues Thr216 and Thr220 on KAY.", "reactants": [ "species_207020", "species_29358" ], "products": [ "species_113582", "species_206830" ], "modifiers": [ [ "species_207020", "catalyst" ] ], "additional_components": [ "P21525", "phospho-kay", "P18289", "phospho-Jra", "Q9VLT9", "CKA", "P92208", "bsk", "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q9VLT9", "CKA", "P92208", "bsk", "P21525", "phospho-kay", "P18289", "phospho-Jra", "Q9VLT9", "CKA", "P92208", "bsk" ] }, "reaction_209193": { "compartment": "compartment_7660", "id": "reaction_209193", "reactome": "R-DME-209193", "name": "Phosphorylated AP-1, Phospho JRA:Phospho KAY dissociates from CKA", "reversible": "false", "notes": "The phosphorylated AP-1 transcription factor, JRA:KAY dissociates from the scaffolding protein CKA.", "reactants": [ "species_206830" ], "products": [ "species_206892", "species_206657" ], "modifiers": [], "additional_components": [ "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q9VLT9", "CKA", "P92208", "bsk", "Q9VLT9", "CKA", "P92208", "bsk", "P18289", "phospho-Jra", "P21525", "phospho-kay" ] }, "reaction_209358": { "compartment": "compartment_7660", "id": "reaction_209358", "reactome": "R-DME-209358", "name": "Phosphorylated AP-1, Phospho JRA:Phospho KAY binds to a target gene and activates transcription", "reversible": "false", "notes": "The phosphorylated AP-1 transcription factor binds to its target genes and activates transcription. One of its target genes encodes the phosphatase Puckered (PUC) which acts as a negative regulator of the pathway as part of a negative feedback loop.In the eye, another transcriptional target, arising from the Frizzled (FZ):Dishevelled (DSH) complex activation in R3 cells, is for the Notch (N) receptor ligand Delta (DL). This will subsequently bind to its receptor N in the neighbouring R4 cell.", "reactants": [ "species_206657" ], "products": [ "species_206657" ], "modifiers": [], "additional_components": [ "P18289", "phospho-Jra", "P21525", "phospho-kay", "P18289", "phospho-Jra", "P21525", "phospho-kay" ] }, "reaction_209298": { "compartment": "compartment_70101", "id": "reaction_209298", "reactome": "R-DME-209298", "name": "BSK is phosphorylated and activated by phosphorylated HEP kinase", "reversible": "false", "notes": "Basket (BSK) is phosphorylated and activated when residues Thr181 and Tyr183 (Thr183 an Tyr185 in human JNK1) are phosphorylated by dual-specificity kinase, Hemipterous (HEP).", "reactants": [ "species_206638", "species_113592" ], "products": [ "species_29370", "species_206913" ], "modifiers": [ [ "species_206638", "catalyst" ] ], "additional_components": [ "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA", "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA", "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA" ] }, "reaction_209302": { "compartment": "compartment_70101", "id": "reaction_209302", "reactome": "R-DME-209302", "name": "Phosphorylated BSK kinase dissociates from CKA scaffolding protein", "reversible": "false", "notes": "The phosphorylation of the scaffold protein CKA probably results in a conformational change resulting in the dissociation of the phosphorylated Basket (BSK) kinase.", "reactants": [ "species_206943" ], "products": [ "species_206789", "species_206213" ], "modifiers": [], "additional_components": [ "Q23977", "Phospho HEP", "Q9VLT9", "CKA", "P92208", "bsk", "Q23977", "Phospho HEP", "Q9VLT9", "CKA" ] }, "reaction_209157": { "compartment": "compartment_70101", "id": "reaction_209157", "reactome": "R-DME-209157", "name": "Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase", "reversible": "false", "notes": "The JUN kinase phosphatase Puckered (PUC) dephosphorylates and consequently deactivates the phosphorylated Basket (BSK) kinase. The gene that encodes PUC is a target of the AP-1 transcription factor making this interaction part of a regulatory negative feedback loop.", "reactants": [ "species_206213" ], "products": [ "species_29372", "species_206251" ], "modifiers": [ [ "species_205899", "catalyst" ] ], "additional_components": [] }, "reaction_209183": { "compartment": "compartment_70101", "id": "reaction_209183", "reactome": "R-DME-209183", "name": "Scaffolding protein CKA binds BSK and phosphorylated HEP kinases", "reversible": "false", "notes": "The multidomain scaffolding protein, connector of kinase to AP-1 (CKA) binds phosphorylated Hemipterous (HEP) and the MAP kinase/JNK orthologue, Basket (BSK).", "reactants": [ "species_205833", "species_206251", "species_205776" ], "products": [ "species_206638" ], "modifiers": [], "additional_components": [ "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA" ] }, "reaction_209199": { "compartment": "compartment_70101", "id": "reaction_209199", "reactome": "R-DME-209199", "name": "CKA is phosphorylated by phosphorylated BSK kinase", "reversible": "false", "notes": "The scaffolding protein CKA is phosphorylated by phosphorylated Basket (BSK) kinase.", "reactants": [ "species_113592", "species_206913" ], "products": [ "species_206943", "species_29370" ], "modifiers": [ [ "species_206913", "catalyst" ] ], "additional_components": [ "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA", "Q23977", "Phospho HEP", "Q9VLT9", "CKA", "P92208", "bsk", "Q23977", "Phospho HEP", "P92208", "bsk", "Q9VLT9", "CKA" ] }, "reaction_10439486": { "compartment": "compartment_7660", "id": "reaction_10439486", "reactome": "R-DME-188371", "name": "Association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438214", "species_10427405" ], "products": [ "species_10438216" ], "modifiers": [], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438221": { "compartment": "compartment_7660", "id": "reaction_10438221", "reactome": "R-DME-174079", "name": "Phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438216" ], "products": [ "species_113582", "species_10438218" ], "modifiers": [ [ "species_10438216", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438380": { "compartment": "compartment_7660", "id": "reaction_10438380", "reactome": "R-DME-174251", "name": "Phosphorylation of Cdh1 by Cyclin B1:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438212" ], "products": [ "species_113582", "species_10438066" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "FBgn0262699", "FBgn0262699", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10435471": { "compartment": "compartment_70101", "id": "reaction_10435471", "reactome": "R-DME-141423", "name": "Binding of the MCC complex to the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427579", "species_10435467" ], "products": [ "species_10435469" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10435477": { "compartment": "compartment_70101", "id": "reaction_10435477", "reactome": "R-DME-141437", "name": "Formation of the MCC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435460", "species_10435465", "species_10435450", "species_10435455" ], "products": [ "species_10435467" ], "modifiers": [], "additional_components": [ "FBgn0001086", "FBgn0035640", "FBgn0263855", "FBgn0025457", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086" ] }, "reaction_10435475": { "compartment": "compartment_70101", "id": "reaction_10435475", "reactome": "R-DME-141429", "name": "Inactivation of APC/C via CDC20 sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435460", "species_10435465" ], "products": [ "species_10435473" ], "modifiers": [], "additional_components": [ "FBgn0001086", "FBgn0035640", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086" ] }, "reaction_10438247": { "compartment": "compartment_7660", "id": "reaction_10438247", "reactome": "R-DME-174097", "name": "Association of Emi1 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438243", "species_10436108" ], "products": [ "species_10438245" ], "modifiers": [], "additional_components": [ "Q9W4H9", "FBgn0262699", "FBgn0017551", "Q9VM76", "FBgn0017551", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438310": { "compartment": "compartment_7660", "id": "reaction_10438310", "reactome": "R-DME-174139", "name": "Dissociation of phospho-Cdh1 from the APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438102" ], "products": [ "species_10438066", "species_10438100" ], "modifiers": [], "additional_components": [ "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438374": { "compartment": "compartment_7660", "id": "reaction_10438374", "reactome": "R-DME-174235", "name": "Association of Emi1 with Cdc20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438282", "species_10436108" ], "products": [ "species_10438372" ], "modifiers": [], "additional_components": [ "FBgn0001086", "FBgn0017551", "Q9VM76", "FBgn0017551", "Q24044", "FBgn0001086" ] }, "reaction_10438361": { "compartment": "compartment_7660", "id": "reaction_10438361", "reactome": "R-DME-174174", "name": "Phosphorylation of the Emi1 DSGxxS degron by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438286" ], "products": [ "species_113582", "species_10438359" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "Q9VM76", "FBgn0017551", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q9VM76", "FBgn0017551", "FBgn0003124" ] }, "reaction_10438294": { "compartment": "compartment_7660", "id": "reaction_10438294", "reactome": "R-DME-174122", "name": "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438286" ], "products": [ "species_113582", "species_10438291" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q9VM76", "FBgn0017551", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q24044", "FBgn0001086", "Q9W4H9", "FBgn0262699", "Q9VM76", "FBgn0017551", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10438382": { "compartment": "compartment_70101", "id": "reaction_10438382", "reactome": "R-DME-174255", "name": "Degradation multiubiquitinated Cyclin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438253" ], "products": [ "species_10434593", "species_10426987", "species_10435469" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106", "FBgn0004106", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10438355": { "compartment": "compartment_70101", "id": "reaction_10438355", "reactome": "R-DME-174171", "name": "Association of Cyclin A with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438249", "species_10435469" ], "products": [ "species_10438251" ], "modifiers": [], "additional_components": [ "P23572", "FBgn0004106", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106" ] }, "reaction_10438256": { "compartment": "compartment_70101", "id": "reaction_10438256", "reactome": "R-DME-174104", "name": "Ubiquitination of Cyclin A by APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10438251" ], "products": [ "species_10438253" ], "modifiers": [ [ "species_10435469", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "P23572", "FBgn0004106", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10439023": { "compartment": "compartment_70101", "id": "reaction_10439023", "reactome": "R-DME-179417", "name": "Multiubiquitination of Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439016", "species_10426987" ], "products": [ "species_10439020" ], "modifiers": [ [ "species_10439016", "catalyst" ] ], "additional_components": [ "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970" ] }, "reaction_10439018": { "compartment": "compartment_70101", "id": "reaction_10439018", "reactome": "R-DME-179410", "name": "Association of Nek2A with MCC:APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439014", "species_10435469" ], "products": [ "species_10439016" ], "modifiers": [], "additional_components": [ "FBgn0029970", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970" ] }, "reaction_10439025": { "compartment": "compartment_70101", "id": "reaction_10439025", "reactome": "R-DME-179421", "name": "Degradation of multiubiquitinated Nek2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439020" ], "products": [ "species_10426987", "species_10435469" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W3N8", "FBgn0029970", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10438378": { "compartment": "compartment_70101", "id": "reaction_10438378", "reactome": "R-DME-174238", "name": "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435469" ], "products": [ "species_10438276", "species_10438376" ], "modifiers": [], "additional_components": [ "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VAJ2", "FBgn0025457", "A1Z6I7", "FBgn0263855", "Q9VRQ2", "FBgn0035640" ] }, "reaction_10438280": { "compartment": "compartment_70101", "id": "reaction_10438280", "reactome": "R-DME-174120", "name": "Association of Cyclin B:Cdc2 with Cdc20:APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438276", "species_10437675" ], "products": [ "species_10438278" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086" ] }, "reaction_10438325": { "compartment": "compartment_70101", "id": "reaction_10438325", "reactome": "R-DME-174157", "name": "Degradation of multiubiquitinated Cyclin B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438323" ], "products": [ "species_10434593", "species_10438276", "species_10426987" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "FBgn0004106", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10438370": { "compartment": "compartment_70101", "id": "reaction_10438370", "reactome": "R-DME-174227", "name": "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438278", "species_10426987" ], "products": [ "species_10438323" ], "modifiers": [ [ "species_10438276", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086" ] }, "reaction_10438366": { "compartment": "compartment_70101", "id": "reaction_10438366", "reactome": "R-DME-174202", "name": "Degradation of multiubiquitinated Securin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438318" ], "products": [ "species_10438276", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10438321": { "compartment": "compartment_70101", "id": "reaction_10438321", "reactome": "R-DME-174144", "name": "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438314", "species_10426987" ], "products": [ "species_10438318" ], "modifiers": [ [ "species_10438276", "catalyst" ] ], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086" ] }, "reaction_10438308": { "compartment": "compartment_7660", "id": "reaction_10438308", "reactome": "R-DME-174132", "name": "Free APC/C phosphorylated by Cyclin B:Cdc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438100" ], "products": [ "species_10438100" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10438274": { "compartment": "compartment_7660", "id": "reaction_10438274", "reactome": "R-DME-174119", "name": "Free APC/C phosphorylated by Plk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438100" ], "products": [ "species_10438100" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "FBgn0003124" ] }, "reaction_10438107": { "compartment": "compartment_7660", "id": "reaction_10438107", "reactome": "R-DME-174057", "name": "Multiubiquitination of APC/C-associated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10438102" ], "products": [ "species_10438104" ], "modifiers": [ [ "species_10438102", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438208": { "compartment": "compartment_7660", "id": "reaction_10438208", "reactome": "R-DME-174058", "name": "Degradation of multiubiquitinated Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438104" ], "products": [ "species_10438100", "species_10427430" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10438306": { "compartment": "compartment_70101", "id": "reaction_10438306", "reactome": "R-DME-174124", "name": "Dephosphorylation of phospho-Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10438296" ], "products": [ "species_111294", "species_10427584" ], "modifiers": [ [ "species_10438303", "catalyst" ] ], "additional_components": [ "FBgn0262699", "FBgn0262699" ] }, "reaction_10438210": { "compartment": "compartment_70101", "id": "reaction_10438210", "reactome": "R-DME-174070", "name": "Association of Cdh1 with the APC/C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427584", "species_10427579" ], "products": [ "species_10427586" ], "modifiers": [], "additional_components": [ "FBgn0262699", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438368": { "compartment": "compartment_70101", "id": "reaction_10438368", "reactome": "R-DME-174224", "name": "Dissociation of Cdc20 from APC/C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438276" ], "products": [ "species_10435460", "species_10427579" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q24044", "FBgn0001086", "FBgn0001086", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848" ] }, "reaction_10498544": { "compartment": "compartment_7660", "id": "reaction_10498544", "reactome": "R-DME-9686969", "name": "APC/C:Cdh1 polyubiquitinates SKP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498541", "species_10427430" ], "products": [ "species_10439482" ], "modifiers": [ [ "species_10498541", "catalyst" ] ], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879" ] }, "reaction_10438364": { "compartment": "compartment_70101", "id": "reaction_10438364", "reactome": "R-DME-174195", "name": "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10438239" ], "products": [ "species_10438258" ], "modifiers": [ [ "species_10438239", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699" ] }, "reaction_10438260": { "compartment": "compartment_70101", "id": "reaction_10438260", "reactome": "R-DME-174105", "name": "Degradation of multiubiquitinated cell cycle proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438258" ], "products": [ "species_10427586", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10438241": { "compartment": "compartment_70101", "id": "reaction_10438241", "reactome": "R-DME-174088", "name": "Association of cell cycle proteins with the APC/C:Cdh1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427586", "species_10438237" ], "products": [ "species_10438239" ], "modifiers": [], "additional_components": [ "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "P52304", "FBgn0003124", "Q9VKN7", "FBgn0024227", "Q9VGF9", "FBgn0000147", "Q24044", "FBgn0001086", "Q9VTY6", "FBgn0264848", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9W4H9", "FBgn0262699" ] }, "reaction_10472877": { "compartment": "compartment_70101", "id": "reaction_10472877", "reactome": "R-DME-5607722", "name": "Active NIK phosphorylates IKKA dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10472874", "species_10446829" ], "products": [ "species_29370", "species_10472862" ], "modifiers": [ [ "species_10446829", "catalyst" ] ], "additional_components": [ "Q9VEZ5", "phospho-IKKbeta", "FBgn0024329", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "FBgn0024329" ] }, "reaction_10472872": { "compartment": "compartment_70101", "id": "reaction_10472872", "reactome": "R-DME-5607721", "name": "Activation of NIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446829" ], "products": [ "species_10446829" ], "modifiers": [], "additional_components": [ "FBgn0024329", "FBgn0024329" ] }, "reaction_10472920": { "compartment": "compartment_70101", "id": "reaction_10472920", "reactome": "R-DME-5607731", "name": "26S proteasome processes p-7S-p100:RELB to form p52:RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472913" ], "products": [ "species_10472918", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "P15330", "dl", "Q94527", "Rel", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10472935": { "compartment": "compartment_7660", "id": "reaction_10472935", "reactome": "R-DME-5607741", "name": "p52:RELB translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472918" ], "products": [ "species_10472933" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P15330", "dl", "Q94527", "Rel", "P15330", "dl" ] }, "reaction_10472870": { "compartment": "compartment_70101", "id": "reaction_10472870", "reactome": "R-DME-5607720", "name": "p100:RELB binds active NIK:p-IKKA dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472866", "species_10472862" ], "products": [ "species_10472868" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P15330", "dl", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl" ] }, "reaction_10472916": { "compartment": "compartment_70101", "id": "reaction_10472916", "reactome": "R-DME-5607726", "name": "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472868", "species_113592" ], "products": [ "species_29370", "species_10472890" ], "modifiers": [ [ "species_10472868", "catalyst" ] ], "additional_components": [ "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl", "Q8MSQ4", "FBgn0024329", "Q9VEZ5", "phospho-IKKbeta", "Q94527", "Rel", "P15330", "dl" ] }, "reaction_10475005": { "compartment": "compartment_70101", "id": "reaction_10475005", "reactome": "R-DME-5654573", "name": "Activated FGFR1 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465461", "species_10474909" ], "products": [ "species_10475003" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475036": { "compartment": "compartment_70101", "id": "reaction_10475036", "reactome": "R-DME-5654600", "name": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475031", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296" ] }, "reaction_10475033": { "compartment": "compartment_876", "id": "reaction_10475033", "reactome": "R-DME-5654597", "name": "Activated FGFR1:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475013" ], "products": [ "species_10475031" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296" ] }, "reaction_10475016": { "compartment": "compartment_70101", "id": "reaction_10475016", "reactome": "R-DME-5654582", "name": "Activated FGFR1 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475003" ], "products": [ "species_29370", "species_10475013" ], "modifiers": [ [ "species_10475003", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10434311": { "compartment": "compartment_70101", "id": "reaction_10434311", "reactome": "R-DME-111925", "name": "cAMP induces dissociation of inactive PKA tetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434307" ], "products": [ "species_10434309", "species_10434303" ], "modifiers": [], "additional_components": [ "species_30389", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "species_30389", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10433343": { "compartment": "compartment_5460", "id": "reaction_10433343", "reactome": "R-DME-109338", "name": "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77358" ], "products": [ "species_77360" ], "modifiers": [ [ "species_10433340", "catalyst" ] ], "additional_components": [ "Q9VL68", "FBgn0032160" ] }, "reaction_10433820": { "compartment": "compartment_5460", "id": "reaction_10433820", "reactome": "R-DME-109998", "name": "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109994" ], "products": [ "species_77343" ], "modifiers": [ [ "species_10433340", "catalyst" ] ], "additional_components": [ "Q9VL68", "FBgn0032160" ] }, "reaction_10433345": { "compartment": "compartment_5460", "id": "reaction_10433345", "reactome": "R-DME-109341", "name": "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_109986" ], "products": [ "species_109990", "species_31649" ], "modifiers": [ [ "species_10433219", "catalyst" ] ], "additional_components": [ "Q9VSA3", "FBgn0035811" ] }, "reaction_10469608": { "compartment": "compartment_7660", "id": "reaction_10469608", "reactome": "R-DME-4085372", "name": "PIAS1 SUMOylates SAFB with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469602", "species_10467300" ], "products": [ "species_10467222", "species_10469606" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0039229", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "FBgn0039229", "FBgn0003612" ] }, "reaction_10469156": { "compartment": "compartment_7660", "id": "reaction_10469156", "reactome": "R-DME-3900194", "name": "PIAS1 SUMOylates DDX5 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429510", "species_10467290" ], "products": [ "species_10469153", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0035720", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0035720", "FBgn0010602", "FBgn0003612" ] }, "reaction_10467491": { "compartment": "compartment_7660", "id": "reaction_10467491", "reactome": "R-DME-3108203", "name": "PRC1 SUMOylates CTBP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10467421" ], "products": [ "species_10467424", "species_10467222" ], "modifiers": [ [ "species_10467488", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0020496", "FBgn0020496", "FBgn0010602", "P26017", "FBgn0003042", "Q9VB08", "FBgn0003330", "Q9VHA0", "FBgn0003334", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "P39769", "FBgn0004861", "Q9VKL0", "FBgn0032330", "Q9W523", "FBgn0004860" ] }, "reaction_10469619": { "compartment": "compartment_7660", "id": "reaction_10469619", "reactome": "R-DME-4086059", "name": "SUMOylation of NPM1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469613" ], "products": [ "species_10469616", "species_10467222" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0016685", "FBgn0016685", "FBgn0010602", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10471853": { "compartment": "compartment_7660", "id": "reaction_10471853", "reactome": "R-DME-5358510", "name": "MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427633", "species_10471849", "species_10471835" ], "products": [ "species_10471851" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655" ] }, "reaction_10471868": { "compartment": "compartment_7660", "id": "reaction_10471868", "reactome": "R-DME-5358592", "name": "DNA ligase I ligates single stranded nick in double stranded DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_5358610" ], "products": [ "species_109966", "species_164121", "species_113541" ], "modifiers": [ [ "species_10427699", "catalyst" ] ], "additional_components": [ "FBgn0262619" ] }, "reaction_10471882": { "compartment": "compartment_7660", "id": "reaction_10471882", "reactome": "R-DME-5358912", "name": "MSH2:MSH6 exchanges ADP for ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10471862" ], "products": [ "species_113582", "species_10471849" ], "modifiers": [], "additional_components": [ "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546" ] }, "reaction_10471864": { "compartment": "compartment_7660", "id": "reaction_10471864", "reactome": "R-DME-5358525", "name": "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471860", "species_5358514" ], "products": [ "species_10471862" ], "modifiers": [], "additional_components": [ "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370", "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370" ] }, "reaction_10471880": { "compartment": "compartment_7660", "id": "reaction_10471880", "reactome": "R-DME-5358599", "name": "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_10471875" ], "products": [ "species_10471866" ], "modifiers": [ [ "species_10471875", "catalyst" ] ], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "Q24558", "FBgn0015553", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "Q24558", "FBgn0015553" ] }, "reaction_10471877": { "compartment": "compartment_7660", "id": "reaction_10471877", "reactome": "R-DME-5358597", "name": "EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471873", "species_10471855" ], "products": [ "species_10471875" ], "modifiers": [], "additional_components": [ "FBgn0015553", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "Q24558", "FBgn0015553" ] }, "reaction_10472562": { "compartment": "compartment_7660", "id": "reaction_10472562", "reactome": "R-DME-5444523", "name": "Formation of MSH1:PMS2 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471828", "species_10471833" ], "products": [ "species_10471835" ], "modifiers": [], "additional_components": [ "FBgn0011659", "FBgn0011660", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659" ] }, "reaction_10471858": { "compartment": "compartment_7660", "id": "reaction_10471858", "reactome": "R-DME-5358518", "name": "MLH1:PMS2 makes single strand incision near 1-2 base mismatch", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471851" ], "products": [ "species_10471855" ], "modifiers": [ [ "species_10471851", "catalyst" ] ], "additional_components": [ "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655", "A1ZA03", "FBgn0011660", "A1Z7C1", "FBgn0011659", "Q9VUM0", "FBgn0036486", "species_113592", "P43248", "FBgn0015546", "P17917", "FBgn0005655" ] }, "reaction_10472560": { "compartment": "compartment_7660", "id": "reaction_10472560", "reactome": "R-DME-5444516", "name": "Formation of MSH2:MSH6 Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113582", "species_10471840", "species_10471845" ], "products": [ "species_10471860" ], "modifiers": [], "additional_components": [ "FBgn0015546", "FBgn0036486", "Q9VUM0", "FBgn0036486", "P43248", "FBgn0015546", "species_29370" ] }, "reaction_10473069": { "compartment": "compartment_70101", "id": "reaction_10473069", "reactome": "R-DME-5610737", "name": "NUMB:ITCH bind and ubiquitnate GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473061", "species_10473055" ], "products": [ "species_10473066" ], "modifiers": [ [ "species_10473055", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9VG38", "FBgn0005355", "P19538", "ci", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10473111": { "compartment": "compartment_70101", "id": "reaction_10473111", "reactome": "R-DME-5610760", "name": "GLI1 is degraded by the proteasome after ubiquitination by ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473066" ], "products": [ "species_10472994", "species_10473055" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0005355", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10473109": { "compartment": "compartment_70101", "id": "reaction_10473109", "reactome": "R-DME-5610758", "name": "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473071" ], "products": [ "species_10472994" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0005355", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10473073": { "compartment": "compartment_5263232", "id": "reaction_10473073", "reactome": "R-DME-5610742", "name": "SCF(beta-TrCP) ubiquitinates p-GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473061", "species_10426987" ], "products": [ "species_10473071" ], "modifiers": [ [ "species_10442677", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10473057": { "compartment": "compartment_70101", "id": "reaction_10473057", "reactome": "R-DME-5610735", "name": "NUMB binds ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456470", "species_10473053" ], "products": [ "species_10473055" ], "modifiers": [], "additional_components": [ "FBgn0003557", "FBgn0002973", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10491420": { "compartment": "compartment_70101", "id": "reaction_10491420", "reactome": "R-DME-8876789", "name": "CARNMT1 methylates CARN to Anserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6786250", "species_71284" ], "products": [ "species_71285", "species_8876775" ], "modifiers": [ [ "species_10491417", "catalyst" ] ], "additional_components": [ "FBgn0023522" ] }, "reaction_10456032": { "compartment": "compartment_70101", "id": "reaction_10456032", "reactome": "R-DME-977301", "name": "Histidine is decarboxylated to histamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29612" ], "products": [ "species_175992", "species_113528" ], "modifiers": [ [ "species_10456029", "catalyst" ] ], "additional_components": [ "Q05733", "FBgn0005619" ] }, "reaction_10464665": { "compartment": "compartment_984", "id": "reaction_10464665", "reactome": "R-DME-2046239", "name": "Extracellular KSPG translocates to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464621" ], "products": [ "species_10461390" ], "modifiers": [], "additional_components": [ "FBgn0028872", "FBgn0028872" ] }, "reaction_10460806": { "compartment": "compartment_161320", "id": "reaction_10460806", "reactome": "R-DME-1638053", "name": "HEXA cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10460515", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10497913": { "compartment": "compartment_161320", "id": "reaction_10497913", "reactome": "R-DME-9638078", "name": "HEXB cleaves the terminal GalNAc from keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105012" ], "products": [ "species_2105010", "species_1605658" ], "modifiers": [ [ "species_10460517", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10460725": { "compartment": "compartment_161320", "id": "reaction_10460725", "reactome": "R-DME-1630306", "name": "GLB1 hydrolyses a glycosaminoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104997" ], "products": [ "species_1605637", "species_2104995" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_10460803": { "compartment": "compartment_161320", "id": "reaction_10460803", "reactome": "R-DME-1638032", "name": "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2104995" ], "products": [ "species_1606845", "species_2105012" ], "modifiers": [ [ "species_10460800", "catalyst" ] ], "additional_components": [ "FBgn0033836" ] }, "reaction_10453964": { "compartment": "compartment_20699", "id": "reaction_10453964", "reactome": "R-DME-744231", "name": "SLC35D2 exchanges UDP-sugars for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744229", "species_735698" ], "products": [ "species_109402", "species_744234" ], "modifiers": [ [ "species_10453959", "catalyst" ] ], "additional_components": [ "species_744227", "species_914003", "species_744227", "species_914003", "FBgn0042641" ] }, "reaction_10464619": { "compartment": "compartment_20699", "id": "reaction_10464619", "reactome": "R-DME-2046175", "name": "Further sulfation on galactose residues produces KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10464596" ], "products": [ "species_742343", "species_10464606" ], "modifiers": [ [ "species_10464616", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "FBgn0051637" ] }, "reaction_10463991": { "compartment": "compartment_20699", "id": "reaction_10463991", "reactome": "R-DME-2025724", "name": "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10463960" ], "products": [ "species_10463973", "species_205687" ], "modifiers": [ [ "species_10463988", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q95RP8", "FBgn0040373", "A1Z8R6", "FBgn0053145", "A1Z8R5", "FBgn0050037", "A1Z8R4", "FBgn0050036", "Q9VZA6", "FBgn0035558", "Q9VLT0", "FBgn0031986", "Q9VLS8", "FBgn0031988", "Q9W1A7", "FBgn0041706" ] }, "reaction_10464663": { "compartment": "compartment_20699", "id": "reaction_10464663", "reactome": "R-DME-2046222", "name": "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10464634" ], "products": [ "species_742343", "species_10464596" ], "modifiers": [ [ "species_10464660", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VMC4", "FBgn0031826", "Q9VMC3", "FBgn0051637" ] }, "reaction_10464631": { "compartment": "compartment_17963", "id": "reaction_10464631", "reactome": "R-DME-2046180", "name": "KSPG is secreted from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464606" ], "products": [ "species_10464621" ], "modifiers": [], "additional_components": [ "FBgn0028872", "FBgn0028872" ] }, "reaction_10464678": { "compartment": "compartment_20699", "id": "reaction_10464678", "reactome": "R-DME-2046265", "name": "B4GALTs transfer Gal to the keratan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463973", "species_735682" ], "products": [ "species_205687", "species_10464668" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10464691": { "compartment": "compartment_20699", "id": "reaction_10464691", "reactome": "R-DME-2046298", "name": "B4GALTs transfer Gal to a branch of keratan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10464668" ], "products": [ "species_10464681", "species_205687" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10463970": { "compartment": "compartment_20699", "id": "reaction_10463970", "reactome": "R-DME-2025723", "name": "B4GALTs transfer Gal to the N-glycan precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10463949" ], "products": [ "species_10463960", "species_205687" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10440396": { "compartment": "compartment_70101", "id": "reaction_10440396", "reactome": "R-DME-193841", "name": "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193830" ], "products": [ "species_29366", "species_193842" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440394": { "compartment": "compartment_70101", "id": "reaction_10440394", "reactome": "R-DME-193824", "name": "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193835", "species_29364" ], "products": [ "species_29366", "species_193830" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440392": { "compartment": "compartment_70101", "id": "reaction_10440392", "reactome": "R-DME-193821", "name": "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_9617026" ], "products": [ "species_193829", "species_29366" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440390": { "compartment": "compartment_70101", "id": "reaction_10440390", "reactome": "R-DME-193816", "name": "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192194" ], "products": [ "species_70106", "species_193835", "species_73473" ], "modifiers": [ [ "species_10440112", "catalyst" ] ], "additional_components": [ "FBgn0036698" ] }, "reaction_10440388": { "compartment": "compartment_70101", "id": "reaction_10440388", "reactome": "R-DME-193800", "name": "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193829", "species_29364" ], "products": [ "species_29366", "species_193843" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10434826": { "compartment": "compartment_7660", "id": "reaction_10434826", "reactome": "R-DME-113504", "name": "Detection of damage during initiation of DNA synthesis in S-phase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427460" ], "products": [ "species_113656", "species_10427272" ], "modifiers": [], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113" ] }, "reaction_10439755": { "compartment": "compartment_984", "id": "reaction_10439755", "reactome": "R-DME-190265", "name": "FGFR4 binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439749", "species_10433467", "species_190915" ], "products": [ "species_10439753" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10458927": { "compartment": "compartment_876", "id": "reaction_10458927", "reactome": "R-DME-1307963", "name": "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10458922" ], "products": [ "species_10433616", "species_29370" ], "modifiers": [ [ "species_10458922", "catalyst" ] ], "additional_components": [ "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10458924": { "compartment": "compartment_70101", "id": "reaction_10458924", "reactome": "R-DME-1307955", "name": "FGFR4 binds HS:KLB:FGF19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439749", "species_10433610", "species_190915", "species_10433614" ], "products": [ "species_10458922" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "FBgn0036659", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10439762": { "compartment": "compartment_876", "id": "reaction_10439762", "reactome": "R-DME-190326", "name": "Autocatalytic phosphorylation of FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439753" ], "products": [ "species_29370", "species_10433612" ], "modifiers": [ [ "species_10439753", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474842": { "compartment": "compartment_876", "id": "reaction_10474842", "reactome": "R-DME-5654163", "name": "Activated FGFR4 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10439290", "species_10465485" ], "products": [ "species_10474831" ], "modifiers": [], "additional_components": [ "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474836": { "compartment": "compartment_70101", "id": "reaction_10474836", "reactome": "R-DME-5654151", "name": "Activated FGFR4 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474831" ], "products": [ "species_10474833", "species_29370" ], "modifiers": [ [ "species_10474831", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_179838", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474848": { "compartment": "compartment_876", "id": "reaction_10474848", "reactome": "R-DME-5654169", "name": "p-4Y-PLCG1 dissociates from activated FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474833" ], "products": [ "species_10441915", "species_10465485" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10475119": { "compartment": "compartment_70101", "id": "reaction_10475119", "reactome": "R-DME-5654659", "name": "Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465487" ], "products": [ "species_10465489" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475132": { "compartment": "compartment_70101", "id": "reaction_10475132", "reactome": "R-DME-5654667", "name": "Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10475128" ], "products": [ "species_10475130" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475188": { "compartment": "compartment_70101", "id": "reaction_10475188", "reactome": "R-DME-5654717", "name": "FGFR4-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465491", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10438947": { "compartment": "compartment_70101", "id": "reaction_10438947", "reactome": "R-DME-177931", "name": "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431812", "species_10438839" ], "products": [ "species_10438945" ], "modifiers": [], "additional_components": [ "FBgn0020622", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475185": { "compartment": "compartment_70101", "id": "reaction_10475185", "reactome": "R-DME-5654714", "name": "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10475182", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475103": { "compartment": "compartment_70101", "id": "reaction_10475103", "reactome": "R-DME-5654651", "name": "Activated FGFR4 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474997", "species_10465485" ], "products": [ "species_10475101" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475117": { "compartment": "compartment_876", "id": "reaction_10475117", "reactome": "R-DME-5654655", "name": "Activated FGFR4 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475112" ], "products": [ "species_29370", "species_10475114" ], "modifiers": [ [ "species_10475112", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10475126": { "compartment": "compartment_70101", "id": "reaction_10475126", "reactome": "R-DME-5654664", "name": "Activated FGFR4:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475110" ], "products": [ "species_10475121" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474949": { "compartment": "compartment_70101", "id": "reaction_10474949", "reactome": "R-DME-5654422", "name": "Activated FGFR4 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474873", "species_10465485" ], "products": [ "species_10474941" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475108": { "compartment": "compartment_876", "id": "reaction_10475108", "reactome": "R-DME-5654653", "name": "Activated FGFR4 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475101" ], "products": [ "species_10475105", "species_29370" ], "modifiers": [ [ "species_10475101", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475124": { "compartment": "compartment_70101", "id": "reaction_10475124", "reactome": "R-DME-5654663", "name": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475121", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474946": { "compartment": "compartment_876", "id": "reaction_10474946", "reactome": "R-DME-5654418", "name": "Activated FGFR4 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474941" ], "products": [ "species_29370", "species_10465487" ], "modifiers": [ [ "species_10474941", "catalyst" ], [ "species_10474944", "inhibitor" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042" ] }, "reaction_10493199": { "compartment": "compartment_70101", "id": "reaction_10493199", "reactome": "R-DME-8941613", "name": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475114", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10474959": { "compartment": "compartment_70101", "id": "reaction_10474959", "reactome": "R-DME-5654425", "name": "Activated FGFR4 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474909", "species_10465485" ], "products": [ "species_10474957" ], "modifiers": [], "additional_components": [ "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10474955": { "compartment": "compartment_876", "id": "reaction_10474955", "reactome": "R-DME-5654423", "name": "Activated FGFR4:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10474951" ], "products": [ "species_10474953" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474965": { "compartment": "compartment_70101", "id": "reaction_10474965", "reactome": "R-DME-5654428", "name": "Activated FGFR4 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474957" ], "products": [ "species_29370", "species_10474951" ], "modifiers": [ [ "species_10474957", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659" ] }, "reaction_10474962": { "compartment": "compartment_70101", "id": "reaction_10474962", "reactome": "R-DME-5654426", "name": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474953", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475194": { "compartment": "compartment_70101", "id": "reaction_10475194", "reactome": "R-DME-5654734", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439154", "species_10475128" ], "products": [ "species_10475157" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10475162": { "compartment": "compartment_70101", "id": "reaction_10475162", "reactome": "R-DME-5654684", "name": "CBL ubiquitinates FRS2 and FGFR4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475157", "species_10426987" ], "products": [ "species_10475159" ], "modifiers": [ [ "species_10475157", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10458638": { "compartment": "compartment_70101", "id": "reaction_10458638", "reactome": "R-DME-1295634", "name": "SPRY2 is serine phosphorylated in response to MAPK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458630" ], "products": [ "species_10458603" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "O44783", "FBgn0014388", "P11346", "Raf", "O44783", "FBgn0014388", "P40417", "FBgn0003256" ] }, "reaction_10458605": { "compartment": "compartment_70101", "id": "reaction_10458605", "reactome": "R-DME-1295604", "name": "B-RAF dissociates from S111/S120 p-SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458603" ], "products": [ "species_10458599", "species_10458601" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "O44783", "FBgn0014388", "FBgn0014388" ] }, "reaction_10458620": { "compartment": "compartment_70101", "id": "reaction_10458620", "reactome": "R-DME-1295622", "name": "SPRY2 binds CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10458607" ], "products": [ "species_10455248", "species_10455223" ], "modifiers": [], "additional_components": [ "FBgn0020224", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10455243": { "compartment": "compartment_70101", "id": "reaction_10455243", "reactome": "R-DME-934559", "name": "SPRY2 is phosphorylated by phosphorylated MNK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10455225" ], "products": [ "species_29370", "species_10455231" ], "modifiers": [ [ "species_10455240", "catalyst" ] ], "additional_components": [ "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "FBgn0017581" ] }, "reaction_10458618": { "compartment": "compartment_70101", "id": "reaction_10458618", "reactome": "R-DME-1295621", "name": "CBL dissociates from ubiquitinated p-SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455250" ], "products": [ "species_10458616", "species_10439032" ], "modifiers": [], "additional_components": [ "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0020224" ] }, "reaction_10458614": { "compartment": "compartment_70101", "id": "reaction_10458614", "reactome": "R-DME-1295613", "name": "SPRY2 binds GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458607", "species_10431791" ], "products": [ "species_10458612" ], "modifiers": [], "additional_components": [ "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "FBgn0004638", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "Q08012", "FBgn0004638" ] }, "reaction_10455253": { "compartment": "compartment_70101", "id": "reaction_10455253", "reactome": "R-DME-934604", "name": "Phosphorylated SPRY2 is ubiquitinated by CBL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455248", "species_10426987" ], "products": [ "species_10455250" ], "modifiers": [ [ "species_10455248", "catalyst" ] ], "additional_components": [ "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224" ] }, "reaction_10458628": { "compartment": "compartment_70101", "id": "reaction_10458628", "reactome": "R-DME-1295632", "name": "PPA2A dephosphorylates SPRY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458625" ], "products": [ "species_10458593", "species_29372" ], "modifiers": [ [ "species_10458625", "catalyst" ] ], "additional_components": [ "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10458595": { "compartment": "compartment_70101", "id": "reaction_10458595", "reactome": "R-DME-1295599", "name": "SPRY2 translocates to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458593" ], "products": [ "species_10455225" ], "modifiers": [], "additional_components": [ "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388" ] }, "reaction_10458609": { "compartment": "compartment_70101", "id": "reaction_10458609", "reactome": "R-DME-1295609", "name": "SRC phosphorylates SPRY2 on Y55 and Y227", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10455225" ], "products": [ "species_29370", "species_10458607" ], "modifiers": [ [ "species_10438975", "catalyst" ], [ "species_10455231", "inhibitor" ] ], "additional_components": [ "P23696", "mts", "P36179", "Pp2A-29B", "O44783", "FBgn0014388", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B", "FBgn0262733", "O44783", "FBgn0014388", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10474993": { "compartment": "compartment_70101", "id": "reaction_10474993", "reactome": "R-DME-5654566", "name": "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474941" ], "products": [ "species_10474944", "species_29370" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "P40417", "FBgn0003256" ] }, "reaction_10466163": { "compartment": "compartment_70101", "id": "reaction_10466163", "reactome": "R-DME-2529020", "name": "CK2 phosphorylates condensin I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466159" ], "products": [ "species_29370", "species_10466149" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "Q9V3A7", "FBgn0015391", "A1Z987", "FBgn0259876", "Q9VIP9", "FBgn0014127", "Q9VAJ1", "FBgn0039680", "Q7KK96", "FBgn0027783", "Q9VIP9", "FBgn0014127", "A1Z987", "FBgn0259876", "Q7KK96", "FBgn0027783", "Q9VAJ1", "FBgn0039680", "Q9V3A7", "FBgn0015391", "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10466161": { "compartment": "compartment_70101", "id": "reaction_10466161", "reactome": "R-DME-2529015", "name": "Dephosphorylation of CK2-modified condensin I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10466149" ], "products": [ "species_29372", "species_10466159" ], "modifiers": [ [ "species_2529006", "catalyst" ] ], "additional_components": [ "Q9VIP9", "FBgn0014127", "A1Z987", "FBgn0259876", "Q7KK96", "FBgn0027783", "Q9VAJ1", "FBgn0039680", "Q9V3A7", "FBgn0015391", "Q9V3A7", "FBgn0015391", "A1Z987", "FBgn0259876", "Q9VIP9", "FBgn0014127", "Q9VAJ1", "FBgn0039680", "Q7KK96", "FBgn0027783" ] }, "reaction_10435527": { "compartment": "compartment_7660", "id": "reaction_10435527", "reactome": "R-DME-156682", "name": "PLK1 phosphorylates NUDC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435521", "species_113592" ], "products": [ "species_29370", "species_10435525" ], "modifiers": [ [ "species_10435513", "catalyst" ] ], "additional_components": [ "FBgn0021768", "FBgn0021768", "FBgn0003124" ] }, "reaction_10466047": { "compartment": "compartment_1598585", "id": "reaction_10466047", "reactome": "R-DME-2468293", "name": "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466044" ], "products": [ "species_29370", "species_10465943" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "A1Z8S6", "FBgn0260012", "Q9VCD8", "FBgn0040283", "O96689", "FBgn0260987", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "Q9VCD8", "FBgn0040283", "O96689", "FBgn0260987", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "Q9W517", "FBgn0004655", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10465958": { "compartment": "compartment_1598585", "id": "reaction_10465958", "reactome": "R-DME-2466068", "name": "Phosphorylation of cohesin by PLK1 at chromosomal arms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10465943" ], "products": [ "species_10465955", "species_29370" ], "modifiers": [ [ "species_10437677", "catalyst" ] ], "additional_components": [ "A1Z8S6", "FBgn0260012", "Q9VCD8", "FBgn0040283", "O96689", "FBgn0260987", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "Q9W517", "FBgn0004655", "O96689", "FBgn0260987", "Q9VCD8", "FBgn0040283", "Q9VM62", "FBgn0020616", "Q9W0F4", "FBgn0043865", "Q9VXE9", "FBgn0015615", "A1Z8S6", "FBgn0260012", "Q9W517", "FBgn0004655", "FBgn0003124" ] }, "reaction_10465193": { "compartment": "compartment_7660", "id": "reaction_10465193", "reactome": "R-DME-2168079", "name": "MASTL (GWL) phosphorylates ARPP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10465179" ], "products": [ "species_113582", "species_10465182" ], "modifiers": [ [ "species_10465190", "catalyst" ] ], "additional_components": [ "FBgn0061515", "FBgn0061515", "FBgn0260399" ] }, "reaction_10465827": { "compartment": "compartment_7660", "id": "reaction_10465827", "reactome": "R-DME-2430535", "name": "MASTL phosphorylates ENSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10465822" ], "products": [ "species_113582", "species_10465825" ], "modifiers": [ [ "species_10465190", "catalyst" ] ], "additional_components": [ "FBgn0061515", "FBgn0061515", "FBgn0260399" ] }, "reaction_10467211": { "compartment": "compartment_70101", "id": "reaction_10467211", "reactome": "R-DME-2990882", "name": "CDK1 phosphorylates NUP98", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432243", "species_113592" ], "products": [ "species_29370", "species_10467195" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10471162": { "compartment": "compartment_7660", "id": "reaction_10471162", "reactome": "R-DME-5244669", "name": "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10471135" ], "products": [ "species_113582", "species_10471160" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10470742": { "compartment": "compartment_7660", "id": "reaction_10470742", "reactome": "R-DME-5195402", "name": "CDK1 phosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10469763" ], "products": [ "species_113582", "species_10469757" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "FBgn0263593", "FBgn0263593", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10469782": { "compartment": "compartment_13231", "id": "reaction_10469782", "reactome": "R-DME-4419948", "name": "CTDNEP1:CNEP1R1 dephosphorylates LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10469757" ], "products": [ "species_113550", "species_10469763" ], "modifiers": [ [ "species_10469779", "catalyst" ] ], "additional_components": [ "FBgn0263593", "FBgn0263593", "Q9VRG7", "FBgn0029067", "Q8T0B1", "FBgn0036090" ] }, "reaction_10471029": { "compartment": "compartment_13231", "id": "reaction_10471029", "reactome": "R-DME-5221130", "name": "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_5221122" ], "products": [ "species_113550", "species_5221124" ], "modifiers": [ [ "species_10469763", "catalyst" ] ], "additional_components": [ "FBgn0263593" ] }, "reaction_10445787": { "compartment": "compartment_7660", "id": "reaction_10445787", "reactome": "R-DME-380278", "name": "CCNB1:p-T160-CDK1 phosphorylates NUMA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10445775" ], "products": [ "species_113582", "species_10445785" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q9VGE4", "FBgn0037979", "Q8IR55", "FBgn0002873", "Q9VGE4", "FBgn0037979", "Q8IR55", "FBgn0002873", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10465453": { "compartment": "compartment_20699", "id": "reaction_10465453", "reactome": "R-DME-2214351", "name": "PLK1 phosphorylates GORASP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465445", "species_113592" ], "products": [ "species_29370", "species_10465450" ], "modifiers": [ [ "species_10465445", "catalyst" ] ], "additional_components": [ "P52304", "FBgn0003124", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "O18332", "FBgn0285937", "species_29438", "Q9W289", "FBgn0034697", "P52304", "FBgn0003124", "Q9VW57", "FBgn0036919", "O18332", "FBgn0285937", "species_29438", "P52304", "FBgn0003124", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "O18332", "FBgn0285937", "species_29438" ] }, "reaction_10465713": { "compartment": "compartment_20699", "id": "reaction_10465713", "reactome": "R-DME-2422927", "name": "MAPK3-3 or MAPK1 phosphorylate GORASP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465698", "species_113592" ], "products": [ "species_29370", "species_10465704" ], "modifiers": [ [ "species_10465710", "catalyst" ] ], "additional_components": [ "Q9VHE3", "FBgn0037688", "Q9VW57", "FBgn0036919", "O18333", "FBgn0014009", "species_29438", "Q9VHE3", "FBgn0037688", "Q9VW57", "FBgn0036919", "O18333", "FBgn0014009", "species_29438" ] }, "reaction_10465820": { "compartment": "compartment_7660", "id": "reaction_10465820", "reactome": "R-DME-2429719", "name": "MCPH1 sequesters condensin II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450944", "species_10465223", "species_10465816" ], "products": [ "species_10465818" ], "modifiers": [], "additional_components": [ "FBgn0014879", "Q9VMQ4", "FBgn0051989", "Q9V3A7", "FBgn0015391", "Q8INL2", "FBgn0037831", "Q7KK96", "FBgn0027783", "FBgn0260959", "E1JH39", "FBgn0260959", "Q9VMQ4", "FBgn0051989", "Q9V3A7", "FBgn0015391", "Q8INL2", "FBgn0037831", "Q7KK96", "FBgn0027783", "P53997", "FBgn0014879" ] }, "reaction_10498393": { "compartment": "compartment_70101", "id": "reaction_10498393", "reactome": "R-DME-9667965", "name": "ANKLE2 binds PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467266", "species_10455162" ], "products": [ "species_10498391" ], "modifiers": [], "additional_components": [ "FBgn0028343", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q8MQX9", "FBgn0028343" ] }, "reaction_10497739": { "compartment": "compartment_13231", "id": "reaction_10497739", "reactome": "R-DME-9624798", "name": "LBR binds KPNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497735", "species_10443115" ], "products": [ "species_10497737" ], "modifiers": [], "additional_components": [ "FBgn0034657", "FBgn0262743", "O18388", "FBgn0262743", "Q8MLV1", "FBgn0034657" ] }, "reaction_10497741": { "compartment": "compartment_70101", "id": "reaction_10497741", "reactome": "R-DME-9624800", "name": "CDK1 phosphorylates LBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440460" ], "products": [ "species_29370", "species_10497735" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "FBgn0034657", "FBgn0034657", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10467280": { "compartment": "compartment_70101", "id": "reaction_10467280", "reactome": "R-DME-2995389", "name": "ANKLE2 binds VRK1,(VRK2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467266", "species_10467276" ], "products": [ "species_10467278" ], "modifiers": [], "additional_components": [ "FBgn0028343", "Q7KRY6", "FBgn0027889", "Q7KMI3", "FBgn0027504", "Q7KRY6", "FBgn0027889", "Q7KMI3", "FBgn0027504", "Q8MQX9", "FBgn0028343" ] }, "reaction_10498422": { "compartment": "compartment_70101", "id": "reaction_10498422", "reactome": "R-DME-9668389", "name": "VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498413", "species_10498418" ], "products": [ "species_10498420" ], "modifiers": [], "additional_components": [ "Q8I0P1", "FBgn0039141", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "FBgn0283469", "Q9Y162", "FBgn0283469", "Q8I0P1", "FBgn0039141", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10498424": { "compartment": "compartment_13231", "id": "reaction_10498424", "reactome": "R-DME-9668395", "name": "CHMP7 binds CC2D1B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498409", "species_10498405" ], "products": [ "species_10498411" ], "modifiers": [], "additional_components": [ "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "FBgn0261983", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10498426": { "compartment": "compartment_70101", "id": "reaction_10498426", "reactome": "R-DME-9668405", "name": "SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498411", "species_10498400" ], "products": [ "species_10498413" ], "modifiers": [], "additional_components": [ "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "FBgn0039141", "Q8I0P1", "FBgn0039141", "Q9VKJ9", "FBgn0261983", "Q9VRY6", "FBgn0035715", "Q7JRE4", "FBgn0034962", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10497749": { "compartment": "compartment_1598585", "id": "reaction_10497749", "reactome": "R-DME-9624845", "name": "RCC1 stimulates GDP to GTP exchange on RAN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10442325" ], "products": [ "species_10472625", "species_29420" ], "modifiers": [ [ "species_10497746", "catalyst" ] ], "additional_components": [ "species_29420", "Q9VZ23", "FBgn0020255", "Q9VZ23", "FBgn0020255", "species_29438", "FBgn0002638" ] }, "reaction_10497641": { "compartment": "compartment_70101", "id": "reaction_10497641", "reactome": "R-DME-9618378", "name": "POM121 binds the Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497596", "species_10432171" ], "products": [ "species_10497639" ], "modifiers": [], "additional_components": [ "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VWE6", "FBgn0031052", "FBgn0010660", "Q9W1X4", "FBgn0010660", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VWE6", "FBgn0031052" ] }, "reaction_10497753": { "compartment": "compartment_70101", "id": "reaction_10497753", "reactome": "R-DME-9624876", "name": "RAN:GTP recruits nuclear envelope (NE) membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472625", "species_9624879" ], "products": [ "species_10497751" ], "modifiers": [], "additional_components": [ "Q9VZ23", "FBgn0020255", "species_29438", "Q9VZ23", "FBgn0020255", "species_29438" ] }, "reaction_10497598": { "compartment": "compartment_70101", "id": "reaction_10497598", "reactome": "R-DME-9615901", "name": "AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2537690", "species_10497594", "species_10432219" ], "products": [ "species_10497596" ], "modifiers": [], "additional_components": [ "FBgn0031052", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9VWE6", "FBgn0031052" ] }, "reaction_10436113": { "compartment": "compartment_7660", "id": "reaction_10436113", "reactome": "R-DME-163010", "name": "Down Regulation of Emi1 through Phosphorylation of Emi1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10436108" ], "products": [ "species_113582", "species_10436111" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0017551", "FBgn0017551", "FBgn0003124" ] }, "reaction_10466038": { "compartment": "compartment_7660", "id": "reaction_10466038", "reactome": "R-DME-2468040", "name": "Cohesin binds PDS5 and WAPAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466008", "species_10466010", "species_10466014" ], "products": [ "species_10466016" ], "modifiers": [], "additional_components": [ "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "FBgn0260012", "FBgn0004655", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616" ] }, "reaction_10466067": { "compartment": "compartment_1598585", "id": "reaction_10466067", "reactome": "R-DME-2470935", "name": "Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466016", "species_2537690", "species_10466059" ], "products": [ "species_10466065" ], "modifiers": [], "additional_components": [ "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q7PLI2", "FBgn0026401", "Q9VFC0", "FBgn0038300", "Q7PLI2", "FBgn0026401", "Q9VFC0", "FBgn0038300", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616" ] }, "reaction_10435497": { "compartment": "compartment_7660", "id": "reaction_10435497", "reactome": "R-DME-156673", "name": "Regulation of KIF23 (MKLP1) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10435484" ], "products": [ "species_113582", "species_10435488" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0011692", "FBgn0011692", "FBgn0003124" ] }, "reaction_10435542": { "compartment": "compartment_7660", "id": "reaction_10435542", "reactome": "R-DME-156723", "name": "Regulation of KIF20A (MKL2) by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10435537" ], "products": [ "species_113582", "species_10435540" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0003545", "FBgn0003545", "FBgn0003124" ] }, "reaction_10448542": { "compartment": "compartment_70101", "id": "reaction_10448542", "reactome": "R-DME-428231", "name": "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428256" ], "products": [ "species_428193", "species_428198" ], "modifiers": [ [ "species_10448539", "catalyst" ] ], "additional_components": [ "FBgn0045064" ] }, "reaction_10478169": { "compartment": "compartment_12045", "id": "reaction_10478169", "reactome": "R-DME-5693761", "name": "FA2H hydroxylates CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_428256" ], "products": [ "species_5693768", "species_29356" ], "modifiers": [ [ "species_10478166", "catalyst" ] ], "additional_components": [ "FBgn0050502" ] }, "reaction_10448537": { "compartment": "compartment_70101", "id": "reaction_10448537", "reactome": "R-DME-428214", "name": "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428163" ], "products": [ "species_29370", "species_428275" ], "modifiers": [ [ "species_10448534", "catalyst" ] ], "additional_components": [ "Q9VYY8", "FBgn0030300", "Q9VZW0", "FBgn0052484" ] }, "reaction_10448919": { "compartment": "compartment_12045", "id": "reaction_10448919", "reactome": "R-DME-429699", "name": "CERT [ER] + ceramide [ER] => CERT:ceramide [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448902", "species_428256" ], "products": [ "species_10448900" ], "modifiers": [], "additional_components": [ "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "species_429807", "Q9Y128", "FBgn0027569" ] }, "reaction_10498667": { "compartment": "compartment_70101", "id": "reaction_10498667", "reactome": "R-DME-9695890", "name": "SPNS2 transports S1P from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_419305" ], "modifiers": [ [ "species_10498664", "catalyst" ] ], "additional_components": [ "FBgn0086676" ] }, "reaction_10448914": { "compartment": "compartment_70101", "id": "reaction_10448914", "reactome": "R-DME-429694", "name": "CERT:PPM1L:VAPA/B [ER] => CERT [cytosol] + PPM1L:VAPA/B [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448902" ], "products": [ "species_10448912", "species_10448891" ], "modifiers": [], "additional_components": [ "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515" ] }, "reaction_10448498": { "compartment": "compartment_70101", "id": "reaction_10448498", "reactome": "R-DME-428127", "name": "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_9695889" ], "products": [ "species_113528", "species_76194", "species_428182" ], "modifiers": [ [ "species_10448490", "catalyst" ], [ "species_10448496", "inhibitor" ] ], "additional_components": [ "Q6NR46", "FBgn0086532", "Q9V3F2", "FBgn0002524", "A8DYH6", "FBgn0085223", "FBgn0037110" ] }, "reaction_10448464": { "compartment": "compartment_70101", "id": "reaction_10448464", "reactome": "R-DME-428123", "name": "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_428182" ], "products": [ "species_29366", "species_428163" ], "modifiers": [ [ "species_10448461", "catalyst" ] ], "additional_components": [ "FBgn0039304" ] }, "reaction_10448656": { "compartment": "compartment_984", "id": "reaction_10448656", "reactome": "R-DME-428690", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419305", "species_109276" ], "products": [ "species_109277", "species_428662" ], "modifiers": [ [ "species_10448653", "catalyst" ] ], "additional_components": [ "FBgn0016078" ] }, "reaction_10498672": { "compartment": "compartment_70101", "id": "reaction_10498672", "reactome": "R-DME-9695949", "name": "SPHK2 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10448532", "catalyst" ], [ "species_10498670", "inhibitor" ] ], "additional_components": [ "Q9VYY8", "FBgn0030300", "Q9VZW0", "FBgn0052484", "Q9VYY8", "FBgn0030300", "Q9VZW0", "FBgn0052484" ] }, "reaction_10448909": { "compartment": "compartment_12045", "id": "reaction_10448909", "reactome": "R-DME-429683", "name": "CERT:ceramide [ER] => ceramide [Golgi] + CERT [ER]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448900" ], "products": [ "species_10448902", "species_428270" ], "modifiers": [ [ "species_10448907", "catalyst" ] ], "additional_components": [ "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "species_429807", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "FBgn0020626" ] }, "reaction_10448556": { "compartment": "compartment_70101", "id": "reaction_10448556", "reactome": "R-DME-428273", "name": "SPHK1 phosphorylates SPG to S1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_428193" ], "products": [ "species_428203", "species_29370" ], "modifiers": [ [ "species_10446693", "catalyst" ] ], "additional_components": [ "FBgn0030300" ] }, "reaction_10448523": { "compartment": "compartment_20699", "id": "reaction_10448523", "reactome": "R-DME-428205", "name": "ceramide + H2O => stearate + sphingosine [Golgi]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428270" ], "products": [ "species_428248", "species_8934421" ], "modifiers": [ [ "species_10448520", "catalyst" ] ], "additional_components": [ "FBgn0045064" ] }, "reaction_10495317": { "compartment": "compartment_12045", "id": "reaction_10495317", "reactome": "R-DME-8959462", "name": "SAMD8 transforms PE and CERA to CPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959490", "species_8959486" ], "products": [ "species_8959463" ], "modifiers": [ [ "species_10495314", "catalyst" ] ], "additional_components": [ "FBgn0052380" ] }, "reaction_10448553": { "compartment": "compartment_70101", "id": "reaction_10448553", "reactome": "R-DME-428260", "name": "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428126", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_9025544" ], "modifiers": [ [ "species_10448547", "catalyst" ] ], "additional_components": [ "FBgn0001941" ] }, "reaction_10448648": { "compartment": "compartment_70101", "id": "reaction_10448648", "reactome": "R-DME-428681", "name": "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428275" ], "products": [ "species_428686", "species_428663" ], "modifiers": [ [ "species_10448643", "catalyst" ] ], "additional_components": [ "FBgn0010591" ] }, "reaction_10448711": { "compartment": "compartment_70101", "id": "reaction_10448711", "reactome": "R-DME-428696", "name": "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203", "species_29356" ], "products": [ "species_428682", "species_29372" ], "modifiers": [ [ "species_10448708", "catalyst" ] ], "additional_components": [ "Q9V576", "FBgn0016078", "Q9VNT8", "FBgn0037341", "Q9VNU1", "FBgn0037341", "Q9VNU0", "FBgn0037165", "Q7KGH1", "FBgn0041087", "Q9VNT9", "FBgn0037341", "Q9VNU2", "FBgn0037163" ] }, "reaction_10448550": { "compartment": "compartment_70101", "id": "reaction_10448550", "reactome": "R-DME-428259", "name": "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_428206", "species_428126", "species_29368" ], "products": [ "species_428218", "species_29356", "species_428256" ], "modifiers": [ [ "species_10448547", "catalyst" ] ], "additional_components": [ "species_29362", "species_29364", "species_427523", "species_29366", "FBgn0001941" ] }, "reaction_10448646": { "compartment": "compartment_70101", "id": "reaction_10448646", "reactome": "R-DME-428676", "name": "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428203" ], "products": [ "species_428671", "species_428686" ], "modifiers": [ [ "species_10448643", "catalyst" ] ], "additional_components": [ "FBgn0010591" ] }, "reaction_10448932": { "compartment": "compartment_70101", "id": "reaction_10448932", "reactome": "R-DME-429732", "name": "multiphospho-CERT + PPM1L:VAPA/B => multiphospho-CERT:PPM1L:VAPA/B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448923", "species_10448891" ], "products": [ "species_10448927" ], "modifiers": [], "additional_components": [ "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515" ] }, "reaction_10448515": { "compartment": "compartment_70101", "id": "reaction_10448515", "reactome": "R-DME-428185", "name": "sphinganine + stearyl-CoA => dihydroceramide + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_428163" ], "products": [ "species_428126", "species_76194" ], "modifiers": [ [ "species_10448504", "catalyst" ] ], "additional_components": [ "FBgn0040918" ] }, "reaction_10448930": { "compartment": "compartment_70101", "id": "reaction_10448930", "reactome": "R-DME-429730", "name": "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10448927" ], "products": [ "species_29372", "species_10448902" ], "modifiers": [ [ "species_10448927", "catalyst" ] ], "additional_components": [ "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515", "Q9Y128", "FBgn0027569", "Q9Y128", "FBgn0027569", "Q9W4N8", "FBgn0029687", "Q9XZ28", "FBgn0027515" ] }, "reaction_10474424": { "compartment": "compartment_261122", "id": "reaction_10474424", "reactome": "R-DME-5633040", "name": "CSNK1A1 and ADRBK1 dissociate from p-SMO dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474422" ], "products": [ "species_10474420", "species_10474409", "species_10474399" ], "modifiers": [], "additional_components": [ "P32865", "FBgn0260798", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "P91682", "phospho-smo", "P91682", "phospho-smo", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "FBgn0260798" ] }, "reaction_10497842": { "compartment": "compartment_876", "id": "reaction_10497842", "reactome": "R-DME-9632906", "name": "PRKCZ recruits RAS in response to estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438980", "species_10497827" ], "products": [ "species_10497840" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29420", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "P08646", "RAS85D", "species_29420" ] }, "reaction_10497830": { "compartment": "compartment_876", "id": "reaction_10497830", "reactome": "R-DME-9632858", "name": "PRKCZ autophosphorylates downstream of estrogen stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497822", "species_113592" ], "products": [ "species_29370", "species_10497827" ], "modifiers": [ [ "species_10497822", "catalyst" ] ], "additional_components": [ "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10497846": { "compartment": "compartment_7660", "id": "reaction_10497846", "reactome": "R-DME-9632910", "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458634" ], "products": [ "species_10440931" ], "modifiers": [ [ "species_10497844", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "species_29438", "P08646", "RAS85D" ] }, "reaction_10497849": { "compartment": "compartment_876", "id": "reaction_10497849", "reactome": "R-DME-9632918", "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497840" ], "products": [ "species_10497844" ], "modifiers": [], "additional_components": [ "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "P08646", "RAS85D", "species_29420", "A1Z9X0", "FBgn0261854", "Q9W0V1", "Pdk1", "species_179838", "species_29438", "P08646", "RAS85D" ] }, "reaction_10449671": { "compartment": "compartment_172574", "id": "reaction_10449671", "reactome": "R-DME-435171", "name": "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_445829" ], "products": [ "species_445832", "species_1470067" ], "modifiers": [ [ "species_10449668", "catalyst" ] ], "additional_components": [ "species_1562550", "species_111793", "species_266099", "species_1562550", "species_266099", "species_111793", "FBgn0011672" ] }, "reaction_10449893": { "compartment": "compartment_7660", "id": "reaction_10449893", "reactome": "R-DME-442724", "name": "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10449875", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0262866" ] }, "reaction_10497038": { "compartment": "compartment_7660", "id": "reaction_10497038", "reactome": "R-DME-9029434", "name": "p-S363,S380,T573 RS6K translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497030" ], "products": [ "species_10449875" ], "modifiers": [], "additional_components": [ "FBgn0262866", "FBgn0262866" ] }, "reaction_10450823": { "compartment": "compartment_5460", "id": "reaction_10450823", "reactome": "R-DME-449937", "name": "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159450", "species_113521" ], "products": [ "species_113548" ], "modifiers": [ [ "species_10450820", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "O77460", "FBgn0016687" ] }, "reaction_390087": { "compartment": "compartment_70101", "id": "reaction_390087", "reactome": "R-DME-390087", "name": "WTS binds to SAV", "reversible": "false", "notes": "The serine/threonine kinase, Warts (WTS), binds to the WW domain of the scaffolding protein Salvador (SAV). Hippo (HPO) kinase homodimer and WTS bind to different portions of SAV and the three proteins form a ternary complex.", "reactants": [ "species_451812", "species_390037" ], "products": [ "species_451836" ], "modifiers": [], "additional_components": [ "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO" ] }, "reaction_390145": { "compartment": "compartment_70101", "id": "reaction_390145", "reactome": "R-DME-390145", "name": "Phosphorylated HPO dimer phosphorylates SAV", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase homodimer phosphorylates the scaffolding Salvador (SAV) at unknown residues.", "reactants": [ "species_113592", "species_451829" ], "products": [ "species_29370", "species_451860" ], "modifiers": [ [ "species_451829", "catalyst" ] ], "additional_components": [ "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VCR6", "SAV", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q95RA8", "MATS" ] }, "reaction_390112": { "compartment": "compartment_70101", "id": "reaction_390112", "reactome": "R-DME-390112", "name": "Phosphorylated HPO dimer phosphorylates WTS", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase homodimer phosphorylates Warts (WTS) kinase at unknown residues.", "reactants": [ "species_113592", "species_451860" ], "products": [ "species_29370", "species_390172" ], "modifiers": [ [ "species_451860", "catalyst" ] ], "additional_components": [ "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VCR6", "SAV" ] }, "reaction_390035": { "compartment": "compartment_70101", "id": "reaction_390035", "reactome": "R-DME-390035", "name": "HPO dimer autophosphorylates", "reversible": "false", "notes": "The Hippo (HPO) serine/threonine kinase homodimer autophosphorylates on unknown residues and is activated. The scaffolding protein Salvador (SAV) appears to modestly increase the ability of HPO to autophosphorylate.", "reactants": [ "species_451805", "species_113592" ], "products": [ "species_29370", "species_451829" ], "modifiers": [ [ "species_451805", "catalyst" ] ], "additional_components": [ "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q8T0S6", "HPO", "Q9VA38", "WTS", "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q8T0S6", "HPO" ] }, "reaction_390124": { "compartment": "compartment_70101", "id": "reaction_390124", "reactome": "R-DME-390124", "name": "MATS binds to HPO dimer", "reversible": "false", "notes": "Mps one binder kinase activator-like 1 aka Mob as tumor suppressor protein 1 (MATS) associates with Hippo (HPO) kinase to form a complex.", "reactants": [ "species_390158", "species_451836" ], "products": [ "species_451805" ], "modifiers": [], "additional_components": [ "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q95RA8", "MATS", "Q8T0S6", "HPO" ] }, "reaction_390025": { "compartment": "compartment_70101", "id": "reaction_390025", "reactome": "R-DME-390025", "name": "Phosphorylated WTS autophosphorylates", "reversible": "false", "notes": "Phosphorylated Warts (WTS) serine/threonine kinase autophosphorylates at unknown residues. WTS linase is now fully activated.", "reactants": [ "species_113592", "species_390134" ], "products": [ "species_29370", "species_390068" ], "modifiers": [ [ "species_390134", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390011": { "compartment": "compartment_70101", "id": "reaction_390011", "reactome": "R-DME-390011", "name": "HPO dimer binds to SAV", "reversible": "false", "notes": "Hippo (HPO) kinase homodimer associates with the scaffolding protein Salvador (SAV). The C-terminal SARAH (Salvador/Rassf/Hippo) domains of HPO homodimer bind to the N-terminal SARAH domian of SAV.", "reactants": [ "species_390185", "species_390014" ], "products": [ "species_451812" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q9VCR6", "SAV", "Q8T0S6", "HPO" ] }, "reaction_390154": { "compartment": "compartment_70101", "id": "reaction_390154", "reactome": "R-DME-390154", "name": "MATS is phosphorylated by HPO dimer and binds to phosphorylated WTS", "reversible": "false", "notes": "Mps one binder kinase activator-like 1 aka Mob as tumor suppressor protein 1 (MATS) is phosphorylated at unknown residues by the activated Hippo (HPO) serine/threonine kinase homodimer. The phosphorylation of MATS by HPO promotes its binding to Warts (WTS) kinase. MATS helps to activate WTS by relieving an autoinhibitory interaction between the N-terminal region and the C-terminal kinase region of WTS. It appears that MATS cannot simultaneously associate with HPO kinase homodimer and WTS in the same protein complex, so MATS dissociates from HPO homodimer and binds to phosphorylated WTS.", "reactants": [ "species_113592", "species_390172" ], "products": [ "species_29370", "species_390134" ], "modifiers": [ [ "species_390172", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_10476607": { "compartment": "compartment_70101", "id": "reaction_10476607", "reactome": "R-DME-5686073", "name": "GRB2-1:SOS1 binds p-3Y-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10476601" ], "products": [ "species_10476605" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10440940": { "compartment": "compartment_7660", "id": "reaction_10440940", "reactome": "R-DME-198756", "name": "ERK1/2 phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10440887" ], "products": [ "species_113582", "species_10440893" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "FBgn0020412", "FBgn0020412", "P40417", "FBgn0003256" ] }, "reaction_10440938": { "compartment": "compartment_7660", "id": "reaction_10440938", "reactome": "R-DME-198746", "name": "ERK1/2/5 activate RSK1/2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10440901" ], "products": [ "species_113582", "species_10440913" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "FBgn0262866", "FBgn0262866", "P40417", "FBgn0003256" ] }, "reaction_10442249": { "compartment": "compartment_7660", "id": "reaction_10442249", "reactome": "R-DME-203797", "name": "ERKs are inactivated by dual-specific phosphatases (DUSPs)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10440935" ], "products": [ "species_113550", "species_10441236" ], "modifiers": [ [ "species_10442232", "catalyst" ], [ "species_10442247", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "X2JEB8", "FBgn0030976", "Q9VVW5", "FBgn0036844", "X2JEB8", "FBgn0030976", "Q7KMI3", "FBgn0027504", "Q7KRY6", "FBgn0027889" ] }, "reaction_10441253": { "compartment": "compartment_7660", "id": "reaction_10441253", "reactome": "R-DME-199959", "name": "ERKs are inactivated by protein phosphatase 2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10440935" ], "products": [ "species_113550", "species_10441236" ], "modifiers": [ [ "species_10441250", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q8IN89", "FBgn0042693" ] }, "reaction_10440896": { "compartment": "compartment_7660", "id": "reaction_10440896", "reactome": "R-DME-198669", "name": "p38MAPK phosphorylates MSK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10440887" ], "products": [ "species_113582", "species_10440893" ], "modifiers": [ [ "species_10437359", "catalyst" ] ], "additional_components": [ "FBgn0020412", "FBgn0020412", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765" ] }, "reaction_10441211": { "compartment": "compartment_7660", "id": "reaction_10441211", "reactome": "R-DME-199895", "name": "RSK1/2/3 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10440913", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0262866" ] }, "reaction_10441226": { "compartment": "compartment_7660", "id": "reaction_10441226", "reactome": "R-DME-199935", "name": "MSK1 activates CREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10440893", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0020412" ] }, "reaction_10441224": { "compartment": "compartment_7660", "id": "reaction_10441224", "reactome": "R-DME-199917", "name": "MAPKAPK2 phosphorylates CREB at Serine 133", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10441221", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0013987" ] }, "reaction_10441219": { "compartment": "compartment_7660", "id": "reaction_10441219", "reactome": "R-DME-199910", "name": "MSK1 activates ATF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441213" ], "products": [ "species_113582", "species_10441216" ], "modifiers": [ [ "species_10440893", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784", "FBgn0020412" ] }, "reaction_10440286": { "compartment": "compartment_70101", "id": "reaction_10440286", "reactome": "R-DME-193401", "name": "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10440156": { "compartment": "compartment_17951", "id": "reaction_10440156", "reactome": "R-DME-192335", "name": "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_192316" ], "products": [ "species_113575", "species_192342" ], "modifiers": [ [ "species_10440153", "catalyst" ] ], "additional_components": [ "species_113596", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628" ] }, "reaction_10440088": { "compartment": "compartment_70101", "id": "reaction_10440088", "reactome": "R-DME-192033", "name": "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_192136", "species_29364" ], "products": [ "species_191980", "species_29366" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440119": { "compartment": "compartment_70101", "id": "reaction_10440119", "reactome": "R-DME-192160", "name": "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191980", "species_70106", "species_29364" ], "products": [ "species_192030", "species_29366" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440117": { "compartment": "compartment_70101", "id": "reaction_10440117", "reactome": "R-DME-192137", "name": "THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192013", "species_113592", "species_76194" ], "products": [ "species_111294", "species_192096", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10440115": { "compartment": "compartment_70101", "id": "reaction_10440115", "reactome": "R-DME-192097", "name": "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_192114" ], "products": [ "species_70106", "species_192136", "species_73473" ], "modifiers": [ [ "species_10440112", "catalyst" ] ], "additional_components": [ "FBgn0036698" ] }, "reaction_10440275": { "compartment": "compartment_17951", "id": "reaction_10440275", "reactome": "R-DME-193369", "name": "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_193442" ], "products": [ "species_113575", "species_193459" ], "modifiers": [ [ "species_10440153", "catalyst" ] ], "additional_components": [ "species_113596", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628" ] }, "reaction_10440107": { "compartment": "compartment_70101", "id": "reaction_10440107", "reactome": "R-DME-192067", "name": "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192195" ], "products": [ "species_29366", "species_192064" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440299": { "compartment": "compartment_17951", "id": "reaction_10440299", "reactome": "R-DME-193535", "name": "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_193459" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440105": { "compartment": "compartment_17951", "id": "reaction_10440105", "reactome": "R-DME-192056", "name": "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192308" ], "products": [ "species_192316" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440297": { "compartment": "compartment_17951", "id": "reaction_10440297", "reactome": "R-DME-193508", "name": "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732", "species_192307" ], "products": [ "species_193465", "species_193403", "species_192305" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440295": { "compartment": "compartment_17951", "id": "reaction_10440295", "reactome": "R-DME-193455", "name": "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193422", "species_192307" ], "products": [ "species_193465", "species_192305", "species_192339" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440292": { "compartment": "compartment_17951", "id": "reaction_10440292", "reactome": "R-DME-193452", "name": "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193429" ], "products": [ "species_193442" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440290": { "compartment": "compartment_70101", "id": "reaction_10440290", "reactome": "R-DME-193424", "name": "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193505" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10440097": { "compartment": "compartment_70101", "id": "reaction_10440097", "reactome": "R-DME-192036", "name": "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_192064" ], "products": [ "species_29366", "species_192087" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440129": { "compartment": "compartment_17951", "id": "reaction_10440129", "reactome": "R-DME-192331", "name": "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_192342" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10440288": { "compartment": "compartment_70101", "id": "reaction_10440288", "reactome": "R-DME-193407", "name": "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_193505", "species_76194" ], "products": [ "species_111294", "species_193457", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10447126": { "compartment": "compartment_70101", "id": "reaction_10447126", "reactome": "R-DME-399944", "name": "Phosphorylation of CRMPs by Cdk5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447104", "species_113592", "species_10447082" ], "products": [ "species_10447123", "species_29370" ], "modifiers": [ [ "species_10447104", "catalyst" ] ], "additional_components": [ "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259" ] }, "reaction_10447158": { "compartment": "compartment_70101", "id": "reaction_10447158", "reactome": "R-DME-399951", "name": "Phosphorylation of CRMPs by GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447123", "species_113592" ], "products": [ "species_10447155", "species_29370" ], "modifiers": [ [ "species_10440540", "catalyst" ] ], "additional_components": [ "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q8IPQ2", "FBgn0023023", "Q9V3H5", "FBgn0027491", "P48609", "FBgn0013762", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P83101", "FBgn0046332", "P18431", "sgg" ] }, "reaction_10447140": { "compartment": "compartment_70101", "id": "reaction_10447140", "reactome": "R-DME-399947", "name": "Tyrosine phosphorylation of CRMPs by Fes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447082", "species_10447002" ], "products": [ "species_10447137", "species_29370" ], "modifiers": [ [ "species_10442644", "catalyst" ] ], "additional_components": [ "Q8IPQ2", "FBgn0023023", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "Q8IPQ2", "FBgn0023023", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "FBgn0000723" ] }, "reaction_10447319": { "compartment": "compartment_70101", "id": "reaction_10447319", "reactome": "R-DME-416594", "name": "LARG and PDZ-RhoGEF binds to Plexin-B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447312", "species_10442527" ], "products": [ "species_10447314" ], "modifiers": [], "additional_components": [ "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731", "FBgn0023172", "A1ZAN6", "FBgn0023172", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731" ] }, "reaction_10444630": { "compartment": "compartment_70101", "id": "reaction_10444630", "reactome": "R-DME-373750", "name": "SEMA4D interacts with Plexin-B1:ErbB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10444615", "species_10444599" ], "products": [ "species_10444627", "species_29370" ], "modifiers": [ [ "species_10444615", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740" ] }, "reaction_10447317": { "compartment": "compartment_70101", "id": "reaction_10447317", "reactome": "R-DME-416588", "name": "Activation of Rho by LARG and PDZ-RhoGEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447308" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10447314", "catalyst" ] ], "additional_components": [ "species_29420", "P48148", "Rho1", "P48148", "Rho1", "species_29438", "A1ZAN6", "FBgn0023172", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P04412", "FBgn0003731" ] }, "reaction_10447651": { "compartment": "compartment_70101", "id": "reaction_10447651", "reactome": "R-DME-419049", "name": "ROCK activation by RHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604", "species_10434906" ], "products": [ "species_10447647" ], "modifiers": [ [ "species_10447649", "inhibitor" ] ], "additional_components": [ "FBgn0026181", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181", "Q9VXE3", "FBgn0026181" ] }, "reaction_10498524": { "compartment": "compartment_70101", "id": "reaction_10498524", "reactome": "R-DME-9680443", "name": "ROCK1,2 bind ROCKi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9686558", "species_10441604" ], "products": [ "species_10447649" ], "modifiers": [], "additional_components": [ "FBgn0026181", "Q9VXE3", "FBgn0026181" ] }, "reaction_10447670": { "compartment": "compartment_70101", "id": "reaction_10447670", "reactome": "R-DME-419645", "name": "Dimerization of LIMK1 by Hsp90", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441846", "species_10447166" ], "products": [ "species_10447660" ], "modifiers": [], "additional_components": [ "FBgn0001233", "FBgn0283712", "Q8IR79", "FBgn0283712", "P02828", "FBgn0001233" ] }, "reaction_10447668": { "compartment": "compartment_70101", "id": "reaction_10447668", "reactome": "R-DME-419644", "name": "Transphosphorylation of pLIMK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447660" ], "products": [ "species_10447665", "species_29370", "species_10441846" ], "modifiers": [ [ "species_10447660", "catalyst" ] ], "additional_components": [ "Q8IR79", "FBgn0283712", "P02828", "FBgn0001233", "Q8IR79", "FBgn0283712", "FBgn0001233", "Q8IR79", "FBgn0283712", "P02828", "FBgn0001233" ] }, "reaction_10447074": { "compartment": "compartment_70101", "id": "reaction_10447074", "reactome": "R-DME-399939", "name": "Autophosphorylation of PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447006" ], "products": [ "species_29370", "species_10447071" ], "modifiers": [ [ "species_10447006", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10447169": { "compartment": "compartment_70101", "id": "reaction_10447169", "reactome": "R-DME-399952", "name": "Phosphorylation of LIMK-1 by PAK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447163" ], "products": [ "species_29370", "species_10447166" ], "modifiers": [ [ "species_10447071", "catalyst" ] ], "additional_components": [ "FBgn0283712", "FBgn0283712", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10447008": { "compartment": "compartment_70101", "id": "reaction_10447008", "reactome": "R-DME-399930", "name": "Activation of PAK by Rac1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446523", "species_10447004" ], "products": [ "species_10447006", "species_10446511" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "P00528", "FBgn0262733", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P18106", "FBgn0000723", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698" ] }, "reaction_10447047": { "compartment": "compartment_876", "id": "reaction_10447047", "reactome": "R-DME-399933", "name": "Sema3A binds Nrp-1 bound to PlexinA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447041", "species_10446972" ], "products": [ "species_10447045", "species_10447037" ], "modifiers": [], "additional_components": [ "A8JQT5", "FBgn0265082", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P00528", "FBgn0262733", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "P00528", "FBgn0262733", "FBgn0265082" ] }, "reaction_10447058": { "compartment": "compartment_70101", "id": "reaction_10447058", "reactome": "R-DME-399936", "name": "Inhibition of integrin activation by sequestering PIP5KIgamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447037", "species_10447054" ], "products": [ "species_10447056", "species_10444276" ], "modifiers": [], "additional_components": [ "FBgn0265082", "Q0E8Y1", "FBgn0034789", "Q9VSL8", "FBgn0260442", "A8JQT5", "FBgn0265082", "Q0E8Y1", "FBgn0034789", "FBgn0260442" ] }, "reaction_10449663": { "compartment": "compartment_876", "id": "reaction_10449663", "reactome": "R-DME-434989", "name": "SEMA7A binds to PLXNC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449651", "species_10449659" ], "products": [ "species_10449661" ], "modifiers": [], "additional_components": [ "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740" ] }, "reaction_10447402": { "compartment": "compartment_984", "id": "reaction_10447402", "reactome": "R-DME-416683", "name": "SEMA3E binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447392", "species_10447398" ], "products": [ "species_10447400" ], "modifiers": [], "additional_components": [ "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q7KK54", "FBgn0016059", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259" ] }, "reaction_10447414": { "compartment": "compartment_876", "id": "reaction_10447414", "reactome": "R-DME-416690", "name": "SEMA4A binds to PLXND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447410", "species_10447398" ], "products": [ "species_10447412" ], "modifiers": [], "additional_components": [ "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "Q24323", "FBgn0011260", "Q24322", "FBgn0011259", "Q7KK54", "FBgn0016059" ] }, "reaction_10447429": { "compartment": "compartment_876", "id": "reaction_10447429", "reactome": "R-DME-416698", "name": "SEMA5A binds to PLXNB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447425", "species_10447419" ], "products": [ "species_10447427" ], "modifiers": [], "additional_components": [ "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741", "FBgn0284221", "Q9VTT0", "FBgn0284221", "Q9V4A7", "FBgn0025740", "Q9V491", "FBgn0025741" ] }, "reaction_10446800": { "compartment": "compartment_70101", "id": "reaction_10446800", "reactome": "R-DME-392054", "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10446797", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "P00528", "FBgn0262733", "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617" ] }, "reaction_10444970": { "compartment": "compartment_984", "id": "reaction_10444970", "reactome": "R-DME-375160", "name": "NCAM1 binds to ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114570", "species_10444966" ], "products": [ "species_10444968" ], "modifiers": [], "additional_components": [ "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617", "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617", "species_113592" ] }, "reaction_10445181": { "compartment": "compartment_876", "id": "reaction_10445181", "reactome": "R-DME-376122", "name": "DSCAM/DSCAML1 homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445177" ], "products": [ "species_10445179" ], "modifiers": [], "additional_components": [ "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046" ] }, "reaction_10445193": { "compartment": "compartment_70101", "id": "reaction_10445193", "reactome": "R-DME-376123", "name": "DSCAM associates with Rac1-GTP:pPAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445189", "species_10445167" ], "products": [ "species_10445191" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10451543": { "compartment": "compartment_70101", "id": "reaction_10451543", "reactome": "R-DME-451347", "name": "Activation of JNK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_10437429", "species_29370" ], "modifiers": [ [ "species_10445191", "catalyst" ] ], "additional_components": [ "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10451574": { "compartment": "compartment_70101", "id": "reaction_10451574", "reactome": "R-DME-451366", "name": "Activation of p38MAPK by DSCAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451571", "species_113592" ], "products": [ "species_29370", "species_10439434" ], "modifiers": [ [ "species_10445191", "catalyst" ] ], "additional_components": [ "species_29926", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "species_29926", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10444747": { "compartment": "compartment_70101", "id": "reaction_10444747", "reactome": "R-DME-374662", "name": "Translocation of Ezrin to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444743", "species_179856" ], "products": [ "species_10444745" ], "modifiers": [], "additional_components": [ "FBgn0011661", "species_179856", "P46150", "FBgn0011661" ] }, "reaction_10444759": { "compartment": "compartment_70101", "id": "reaction_10444759", "reactome": "R-DME-374664", "name": "Phosphorylation and activation of Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10444745" ], "products": [ "species_10444752", "species_29370" ], "modifiers": [ [ "species_10441896", "catalyst" ] ], "additional_components": [ "species_179856", "P46150", "FBgn0011661", "P46150", "FBgn0011661", "species_179856", "FBgn0259680" ] }, "reaction_10444447": { "compartment": "compartment_876", "id": "reaction_10444447", "reactome": "R-DME-373707", "name": "Netrin-1 induced DCC clustering", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444421", "species_10444443" ], "products": [ "species_10444445" ], "modifiers": [], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444795": { "compartment": "compartment_70101", "id": "reaction_10444795", "reactome": "R-DME-374701", "name": "Phosphorylation of DCC by Fyn", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10444792" ], "products": [ "species_29370", "species_10444508" ], "modifiers": [ [ "species_10444792", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444449": { "compartment": "compartment_984", "id": "reaction_10444449", "reactome": "R-DME-373711", "name": "DCC interaction with Netrin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444421", "species_10444441" ], "products": [ "species_10444443" ], "modifiers": [], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "FBgn0015773", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444512": { "compartment": "compartment_70101", "id": "reaction_10444512", "reactome": "R-DME-373716", "name": "DCC interacting NCK-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444486", "species_10444508" ], "products": [ "species_10444510" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "P00528", "FBgn0262733", "Q24567", "FBgn0015773", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "Q9VPU1", "dock" ] }, "reaction_10453702": { "compartment": "compartment_876", "id": "reaction_10453702", "reactome": "R-DME-593685", "name": "Netrin-4 binds DCC/UNC5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10453698", "species_10453691" ], "products": [ "species_10453700" ], "modifiers": [], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q95TU8", "FBgn0034013", "FBgn0261800", "P11046", "FBgn0261800", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q95TU8", "FBgn0034013" ] }, "reaction_10444756": { "compartment": "compartment_876", "id": "reaction_10444756", "reactome": "R-DME-374663", "name": "DCC interaction with Ezrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444752", "species_10444421" ], "products": [ "species_10444754" ], "modifiers": [], "additional_components": [ "P46150", "FBgn0011661", "species_179856", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "P46150", "FBgn0011661", "species_179856" ] }, "reaction_10444786": { "compartment": "compartment_70101", "id": "reaction_10444786", "reactome": "R-DME-374667", "name": "DCC interaction with SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444443", "species_10444782" ], "products": [ "species_10444784" ], "modifiers": [], "additional_components": [ "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10444768": { "compartment": "compartment_70101", "id": "reaction_10444768", "reactome": "R-DME-374665", "name": "DCC interaction with SIAH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444443", "species_10444764" ], "products": [ "species_10444766" ], "modifiers": [], "additional_components": [ "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "FBgn0003410", "P21461", "FBgn0003410", "Q24567", "FBgn0015773", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764" ] }, "reaction_10496097": { "compartment": "compartment_984", "id": "reaction_10496097", "reactome": "R-DME-9010815", "name": "SLITs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496093", "species_2299699" ], "products": [ "species_10496095" ], "modifiers": [], "additional_components": [ "Q9VUN0", "FBgn0036494", "P24014", "sli", "species_2299699", "Q9VUN0", "FBgn0036494", "P24014", "sli" ] }, "reaction_10448744": { "compartment": "compartment_70101", "id": "reaction_10448744", "reactome": "R-DME-428888", "name": "Phosphorylation of ROBO1 by ABL kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445201", "species_113592" ], "products": [ "species_29370", "species_10448741" ], "modifiers": [ [ "species_10445201", "catalyst" ] ], "additional_components": [ "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9W213", "FBgn0005631", "M9PC46", "FBgn0002543", "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631" ] }, "reaction_10445203": { "compartment": "compartment_70101", "id": "reaction_10445203", "reactome": "R-DME-376141", "name": "Interaction of ABL with ROBO1:SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442417", "species_10445197" ], "products": [ "species_10445201" ], "modifiers": [], "additional_components": [ "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "P00522", "Abl", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631" ] }, "reaction_10448598": { "compartment": "compartment_876", "id": "reaction_10448598", "reactome": "R-DME-428518", "name": "Glypican-1 (GPC1) binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448594", "species_10448587" ], "products": [ "species_10448596" ], "modifiers": [], "additional_components": [ "Q9VUG1", "FBgn0041604", "CHEBI:17421", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9VUG1", "FBgn0041604", "CHEBI:17421" ] }, "reaction_10496540": { "compartment": "compartment_984", "id": "reaction_10496540", "reactome": "R-DME-9014812", "name": "ROBOs bind keratan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496536", "species_2299699" ], "products": [ "species_10496538" ], "modifiers": [], "additional_components": [ "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "species_2299699", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog" ] }, "reaction_10442419": { "compartment": "compartment_876", "id": "reaction_10442419", "reactome": "R-DME-204364", "name": "ROBO1 binds SLIT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442404", "species_10442415" ], "products": [ "species_10442417" ], "modifiers": [], "additional_components": [ "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631", "Q9VUN0", "FBgn0036494", "P24014", "sli", "Q9VUN0", "FBgn0036494", "P24014", "sli", "M9PC46", "FBgn0002543", "Q9W213", "FBgn0005631" ] }, "reaction_10448585": { "compartment": "compartment_876", "id": "reaction_10448585", "reactome": "R-DME-428510", "name": "ROBO3.1 antagonizes ROBO1/ROBO2 to allow floor plate crossing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448581", "species_10448573" ], "products": [ "species_10448583" ], "modifiers": [], "additional_components": [ "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "Q9VS29", "FBgn0265296", "Q9VN14", "FBgn0037240", "Q7KSE9", "FBgn0261046", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog" ] }, "reaction_10469295": { "compartment": "compartment_876", "id": "reaction_10469295", "reactome": "R-DME-3928591", "name": "EPH:EFN tetramers oligomerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469291", "species_10469293" ], "products": [ "species_10469226" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469436": { "compartment": "compartment_70101", "id": "reaction_10469436", "reactome": "R-DME-3928641", "name": "PAK binds RAC and bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469389", "species_10446511" ], "products": [ "species_10469391" ], "modifiers": [], "additional_components": [ "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469434": { "compartment": "compartment_70101", "id": "reaction_10469434", "reactome": "R-DME-3928640", "name": "PAKs phosphorylate MLC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10450286" ], "products": [ "species_10450386", "species_29370" ], "modifiers": [ [ "species_10469397", "catalyst" ] ], "additional_components": [ "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10469641": { "compartment": "compartment_70101", "id": "reaction_10469641", "reactome": "R-DME-4093329", "name": "EFNBs bind SDCBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469222", "species_10444571" ], "products": [ "species_10469639" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "FBgn0051342", "A8JQY9", "FBgn0051342", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469368": { "compartment": "compartment_70101", "id": "reaction_10469368", "reactome": "R-DME-3928615", "name": "EFNBs bind SFKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444516", "species_10469222" ], "products": [ "species_10469366" ], "modifiers": [], "additional_components": [ "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733" ] }, "reaction_10469400": { "compartment": "compartment_70101", "id": "reaction_10469400", "reactome": "R-DME-3928625", "name": "PAKs autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469391" ], "products": [ "species_29370", "species_10469397" ], "modifiers": [ [ "species_10469391", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469431": { "compartment": "compartment_70101", "id": "reaction_10469431", "reactome": "R-DME-3928639", "name": "p-EFNB binds GRB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444514", "species_10469352" ], "products": [ "species_10469354" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock" ] }, "reaction_10469429": { "compartment": "compartment_876", "id": "reaction_10469429", "reactome": "R-DME-3928633", "name": "bPIX exchanges GTP for GDP on RAC, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442464", "species_29438", "species_10469387" ], "products": [ "species_114549", "species_10469389" ], "modifiers": [ [ "species_10469387", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "P40792", "RAC1_DROME", "species_29438", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539" ] }, "reaction_10469364": { "compartment": "compartment_70101", "id": "reaction_10469364", "reactome": "R-DME-3928614", "name": "EFNB:GRB4 binds GIT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469360", "species_10469354" ], "products": [ "species_10469362" ], "modifiers": [], "additional_components": [ "FBgn0033539", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539" ] }, "reaction_10469426": { "compartment": "compartment_70101", "id": "reaction_10469426", "reactome": "R-DME-3928631", "name": "GIT1 binds bPIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469362", "species_10439144" ], "products": [ "species_10469387" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539", "FBgn0015803", "A8DZ19", "FBgn0015803", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VPU1", "dock", "Q95RG8", "FBgn0033539" ] }, "reaction_10469457": { "compartment": "compartment_876", "id": "reaction_10469457", "reactome": "R-DME-3928651", "name": "NGEF exchanges GTP for GDP on RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10469454", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9VVC6", "FBgn0261547" ] }, "reaction_10469385": { "compartment": "compartment_876", "id": "reaction_10469385", "reactome": "R-DME-3928624", "name": "EPHBs bind EFNBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469206", "species_10469212" ], "products": [ "species_10469222" ], "modifiers": [], "additional_components": [ "FBgn0040324", "FBgn0025936", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469320": { "compartment": "compartment_876", "id": "reaction_10469320", "reactome": "R-DME-3928597", "name": "EPH:EFN dimers tetramerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469293" ], "products": [ "species_10469291" ], "modifiers": [], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469447": { "compartment": "compartment_876", "id": "reaction_10469447", "reactome": "R-DME-3928646", "name": "EPHAs bind EFNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469184", "species_10469171" ], "products": [ "species_10469202" ], "modifiers": [], "additional_components": [ "FBgn0025936", "FBgn0040324", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936" ] }, "reaction_10469285": { "compartment": "compartment_70101", "id": "reaction_10469285", "reactome": "R-DME-3928578", "name": "EPH receptors autophosphorylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469226" ], "products": [ "species_10469282", "species_29370" ], "modifiers": [ [ "species_10469226", "catalyst" ] ], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324" ] }, "reaction_10469657": { "compartment": "compartment_876", "id": "reaction_10469657", "reactome": "R-DME-4093336", "name": "p-TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10469418", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "P91621", "FBgn0085447", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382" ] }, "reaction_10469304": { "compartment": "compartment_70101", "id": "reaction_10469304", "reactome": "R-DME-3928592", "name": "p190RhoGEF exchanges GTP for GDP on RHOA, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10469301", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "M9PBE1", "FBgn0032796" ] }, "reaction_10469654": { "compartment": "compartment_876", "id": "reaction_10469654", "reactome": "R-DME-4093332", "name": "p-EPHB phosphorylates SDC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10461274" ], "products": [ "species_10469651", "species_29370" ], "modifiers": [ [ "species_10469280", "catalyst" ] ], "additional_components": [ "FBgn0010415", "FBgn0010415", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936" ] }, "reaction_10469647": { "compartment": "compartment_70101", "id": "reaction_10469647", "reactome": "R-DME-4093331", "name": "Ras:GTP binds p120-RasGAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_206703", "species_10469643" ], "products": [ "species_10469645" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29438", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "P08646", "RAS85D", "species_29438" ] }, "reaction_10469166": { "compartment": "compartment_876", "id": "reaction_10469166", "reactome": "R-DME-3928576", "name": "RHOA:GTP binds ROCK, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604", "species_10434906" ], "products": [ "species_10447647" ], "modifiers": [], "additional_components": [ "FBgn0026181", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE3", "FBgn0026181" ] }, "reaction_10469421": { "compartment": "compartment_70101", "id": "reaction_10469421", "reactome": "R-DME-3928627", "name": "EPHB phosphorylates TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469413", "species_113592" ], "products": [ "species_29370", "species_10469418" ], "modifiers": [ [ "species_10469413", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P91621", "FBgn0085447", "P91621", "FBgn0085447", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P91621", "FBgn0085447" ] }, "reaction_10469322": { "compartment": "compartment_876", "id": "reaction_10469322", "reactome": "R-DME-3928601", "name": "CDC42 and PIP2 bind WASL, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469312", "species_179856" ], "products": [ "species_10469314" ], "modifiers": [], "additional_components": [ "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341", "species_179856", "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10469383": { "compartment": "compartment_70101", "id": "reaction_10469383", "reactome": "R-DME-3928620", "name": "PAK1 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469374" ], "products": [ "species_10469380", "species_29370" ], "modifiers": [ [ "species_10469374", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469318": { "compartment": "compartment_876", "id": "reaction_10469318", "reactome": "R-DME-3928595", "name": "N-WASP binds ARP2/3 and G-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469314", "species_10461790", "species_10442127" ], "products": [ "species_10469316" ], "modifiers": [], "additional_components": [ "species_179856", "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "species_179856", "M9ND00", "FBgn0023388", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10469445": { "compartment": "compartment_70101", "id": "reaction_10469445", "reactome": "R-DME-3928645", "name": "EPHB:NMDAR binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442480", "species_10469411" ], "products": [ "species_10469413" ], "modifiers": [], "additional_components": [ "FBgn0085447", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P00528", "FBgn0262733", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "P91621", "FBgn0085447" ] }, "reaction_10469668": { "compartment": "compartment_876", "id": "reaction_10469668", "reactome": "R-DME-4093342", "name": "SDC2 multimerises", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469651" ], "products": [ "species_10469666" ], "modifiers": [], "additional_components": [ "FBgn0010415", "P49415", "FBgn0010415" ] }, "reaction_10469376": { "compartment": "compartment_876", "id": "reaction_10469376", "reactome": "R-DME-3928619", "name": "PAK1 binds RAC1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_10442466" ], "products": [ "species_10469374" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10469664": { "compartment": "compartment_876", "id": "reaction_10469664", "reactome": "R-DME-4093339", "name": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10469645" ], "products": [ "species_29372", "species_10469661" ], "modifiers": [ [ "species_10469645", "catalyst" ] ], "additional_components": [ "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "P08646", "RAS85D", "species_29438", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "species_29420", "P08646", "RAS85D", "Q8IR23", "FBgn0003969", "Q9V4E1", "FBgn0040324", "Q9V4E5", "FBgn0025936", "P08646", "RAS85D", "species_29438" ] }, "reaction_10469503": { "compartment": "compartment_876", "id": "reaction_10469503", "reactome": "R-DME-3928656", "name": "gamma-secretase cleaves EPHB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469481" ], "products": [ "species_10469491", "species_10469501" ], "modifiers": [ [ "species_10458502", "catalyst" ] ], "additional_components": [ "FBgn0025936", "FBgn0025936", "FBgn0025936", "Q9VQG2", "FBgn0031458", "Q86BE9", "FBgn0053198", "O02194", "FBgn0284421", "Q9VC27", "FBgn0039234" ] }, "reaction_10469516": { "compartment": "compartment_876", "id": "reaction_10469516", "reactome": "R-DME-3928657", "name": "MMP2,9 cleave EPHB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469222" ], "products": [ "species_10469505", "species_10469206", "species_10469481" ], "modifiers": [ [ "species_10459272", "catalyst" ] ], "additional_components": [ "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "FBgn0025936", "FBgn0040324", "FBgn0025936", "FBgn0035049" ] }, "reaction_10469479": { "compartment": "compartment_876", "id": "reaction_10469479", "reactome": "R-DME-3928654", "name": "Clathrin internalises EPH:EFN complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469475", "species_10439846", "species_10469222", "species_10469463", "species_10439790" ], "products": [ "species_10469477" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "FBgn0003392", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P27619", "FBgn0003392", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10469333": { "compartment": "compartment_876", "id": "reaction_10469333", "reactome": "R-DME-3928607", "name": "p-EPHs bind VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442473", "species_10469324" ], "products": [ "species_10469326" ], "modifiers": [], "additional_components": [ "FBgn0040068", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9NHV9", "FBgn0040068" ] }, "reaction_10469637": { "compartment": "compartment_70101", "id": "reaction_10469637", "reactome": "R-DME-4093327", "name": "EPHA binds TIAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442480", "species_10469438" ], "products": [ "species_10469440" ], "modifiers": [], "additional_components": [ "FBgn0085447", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "P91621", "FBgn0085447" ] }, "reaction_10469331": { "compartment": "compartment_876", "id": "reaction_10469331", "reactome": "R-DME-3928604", "name": "SFKs phosphorylate VAV2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469326" ], "products": [ "species_10469328", "species_29370" ], "modifiers": [ [ "species_10469326", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9NHV9", "FBgn0040068", "Q9NHV9", "FBgn0040068", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "Q9NHV9", "FBgn0040068" ] }, "reaction_10469443": { "compartment": "compartment_876", "id": "reaction_10469443", "reactome": "R-DME-3928642", "name": "TIAM1 exchanges GTP for GDP on RAC1, activating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10469440", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "Q9V4E5", "FBgn0025936", "Q9V4E1", "FBgn0040324", "P00528", "FBgn0262733", "P91621", "FBgn0085447" ] }, "reaction_10450221": { "compartment": "compartment_70101", "id": "reaction_10450221", "reactome": "R-DME-445079", "name": "Phosphorylation of L1 by ERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446836", "species_113592", "species_10433787" ], "products": [ "species_29370", "species_10450218" ], "modifiers": [ [ "species_10433787", "catalyst" ] ], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "FBgn0003256", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "P40417", "FBgn0003256", "Q8T390", "FBgn0038659", "FBgn0003256" ] }, "reaction_10453467": { "compartment": "compartment_876", "id": "reaction_10453467", "reactome": "R-DME-555065", "name": "Formation of clathrin coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438817", "species_10453462" ], "products": [ "species_29372", "species_29420", "species_10446836" ], "modifiers": [ [ "species_10439850", "catalyst" ] ], "additional_components": [ "FBgn0038659", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659" ] }, "reaction_10446838": { "compartment": "compartment_17940", "id": "reaction_10446838", "reactome": "R-DME-392749", "name": "Transport of L1 into endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446836" ], "products": [ "species_10446836" ], "modifiers": [], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659" ] }, "reaction_10444575": { "compartment": "compartment_70101", "id": "reaction_10444575", "reactome": "R-DME-373738", "name": "Neurofascin interacts with syntenin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444571", "species_10444543" ], "products": [ "species_10444573" ], "modifiers": [], "additional_components": [ "FBgn0051342", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "A8JQY9", "FBgn0051342" ] }, "reaction_10444553": { "compartment": "compartment_876", "id": "reaction_10444553", "reactome": "R-DME-373730", "name": "Neurofascin and NrCAM heterodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444549", "species_10444543" ], "products": [ "species_10444551" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388" ] }, "reaction_10449908": { "compartment": "compartment_876", "id": "reaction_10449908", "reactome": "R-DME-443774", "name": "Trans-homodimerization of Neurofascin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449904", "species_10444543" ], "products": [ "species_10449906" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q0KIE7", "FBgn0011747", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q0KIE7", "FBgn0011747" ] }, "reaction_10450094": { "compartment": "compartment_70101", "id": "reaction_10450094", "reactome": "R-DME-445064", "name": "Activation of Rac1 by VAV2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10449774", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "FBgn0040068" ] }, "reaction_10450214": { "compartment": "compartment_70101", "id": "reaction_10450214", "reactome": "R-DME-445072", "name": "Interaction of PAK1 with Rac1-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_351067", "species_113592" ], "products": [ "species_10450211", "species_29370", "species_10446511" ], "modifiers": [ [ "species_10446511", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "species_29438", "FBgn0267698", "FBgn0267698" ] }, "reaction_10433782": { "compartment": "compartment_70101", "id": "reaction_10433782", "reactome": "R-DME-109860", "name": "MAP2K1 phosphorylates MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10433757" ], "products": [ "species_29370", "species_10433773" ], "modifiers": [ [ "species_10433757", "catalyst" ], [ "species_10433778", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10433792": { "compartment": "compartment_70101", "id": "reaction_10433792", "reactome": "R-DME-109862", "name": "MAP2K2 phosphorylates MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433765", "species_113592" ], "products": [ "species_29370", "species_10433789" ], "modifiers": [ [ "species_10433765", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10497559": { "compartment": "compartment_12045", "id": "reaction_10497559", "reactome": "R-DME-9614271", "name": "Autocleavage of ADGRG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497538" ], "products": [ "species_10497556" ], "modifiers": [ [ "species_10497538", "catalyst" ] ], "additional_components": [ "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818", "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818", "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818" ] }, "reaction_10497561": { "compartment": "compartment_876", "id": "reaction_10497561", "reactome": "R-DME-9614273", "name": "ADGRG heterodimer translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497556" ], "products": [ "species_10497556" ], "modifiers": [], "additional_components": [ "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818", "Q9VA10", "FBgn0039821", "A1Z7G7", "FBgn0033313", "Q8SZ78", "FBgn0039818" ] }, "reaction_10437846": { "compartment": "compartment_70101", "id": "reaction_10437846", "reactome": "R-DME-170847", "name": "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437831", "species_10437838" ], "products": [ "species_10437844" ], "modifiers": [], "additional_components": [ "FBgn0011655", "FBgn0025800", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10437955": { "compartment": "compartment_70101", "id": "reaction_10437955", "reactome": "R-DME-173488", "name": "The SMAD2/3:SMAD4 complex transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437844" ], "products": [ "species_10437946" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10459921": { "compartment": "compartment_7660", "id": "reaction_10459921", "reactome": "R-DME-1535903", "name": "Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1535904", "species_10437946", "species_10441099" ], "products": [ "species_10459919" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q95V55", "foxo", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10443101": { "compartment": "compartment_7660", "id": "reaction_10443101", "reactome": "R-DME-211164", "name": "AKT phosphorylates FOXO1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441097" ], "products": [ "species_113582", "species_10441108" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10443105": { "compartment": "compartment_7660", "id": "reaction_10443105", "reactome": "R-DME-211178", "name": "Phosphorylated FOXO1A is excluded from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441108" ], "products": [ "species_10443103" ], "modifiers": [], "additional_components": [] }, "reaction_10486931": { "compartment": "compartment_70101", "id": "reaction_10486931", "reactome": "R-DME-6810843", "name": "Envoplakin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486927", "species_10486925" ], "products": [ "species_10486929" ], "modifiers": [], "additional_components": [ "FBgn0013733", "FBgn0013733", "A1Z9J3", "FBgn0013733" ] }, "reaction_10480300": { "compartment": "compartment_984", "id": "reaction_10480300", "reactome": "R-DME-6789310", "name": "LIPs hydrolyse TG to DAG and RCOOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174675", "species_6789319" ], "modifiers": [ [ "species_10480297", "catalyst" ] ], "additional_components": [ "Q9VPE9", "FBgn0036996", "Q9VG47", "FBgn0038069", "Q9VG46", "FBgn0038070", "Q9VBK6", "FBgn0051091", "Q9V9N3", "FBgn0032981", "Q8IMS3", "FBgn0051091", "Q59E63", "FBgn0034990", "Q9VQQ5", "FBgn0031533", "Q4V6L4", "FBgn0033999", "Q0KI77", "FBgn0038067", "Q9VKT8", "FBgn0032265", "O46108", "FBgn0023495", "Q9VKT7", "FBgn0032266", "O46107", "FBgn0023496", "Q9VKT2", "FBgn0032271", "M9PCU5", "FBgn0032264", "Q9VKT1", "FBgn0051872", "E2QCS7", "FBgn0265264", "Q9VKS9", "FBgn0043825", "Q9VKS5", "FBgn0051871", "Q9VKR5", "FBgn0024740", "Q9VG50", "FBgn0042207", "Q9VG48", "FBgn0038068" ] }, "reaction_10487309": { "compartment": "compartment_876", "id": "reaction_10487309", "reactome": "R-DME-6814187", "name": "EVL:PPL heterodimer binds the inner surface of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983438", "species_10486929" ], "products": [ "species_10486933" ], "modifiers": [], "additional_components": [ "A1Z9J3", "FBgn0013733", "A1Z9J3", "FBgn0013733" ] }, "reaction_10487326": { "compartment": "compartment_70101", "id": "reaction_10487326", "reactome": "R-DME-6814374", "name": "Kazrin binds periplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486927", "species_10487322" ], "products": [ "species_10487324" ], "modifiers": [], "additional_components": [ "FBgn0013733", "FBgn0034720", "A8DYM0", "FBgn0034720", "A1Z9J3", "FBgn0013733" ] }, "reaction_10444879": { "compartment": "compartment_876", "id": "reaction_10444879", "reactome": "R-DME-375138", "name": "CDO binds BOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444869", "species_10444875" ], "products": [ "species_10444877" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388" ] }, "reaction_10450726": { "compartment": "compartment_876", "id": "reaction_10450726", "reactome": "R-DME-448958", "name": "Nuclear translocation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450724" ], "products": [ "species_10450672", "species_10450722" ], "modifiers": [], "additional_components": [ "P00522", "Abl", "Q9VZJ4", "FBgn0035488", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "species_29438", "P40793", "FBgn0010341", "Q9GQF1", "FBgn0024187", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P00522", "Abl", "Q9VZJ4", "FBgn0035488", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "species_29438", "P40793", "FBgn0010341", "Q9GQF1", "FBgn0024187" ] }, "reaction_10450755": { "compartment": "compartment_7660", "id": "reaction_10450755", "reactome": "R-DME-448963", "name": "Interaction of MyoD:E protein with MEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450683", "species_10450751" ], "products": [ "species_10450753" ], "modifiers": [], "additional_components": [ "P40791", "FBgn0011656", "P11420", "FBgn0267821", "P22816", "FBgn0002922", "P11420", "FBgn0267821", "P22816", "FBgn0002922", "P40791", "FBgn0011656" ] }, "reaction_10444914": { "compartment": "compartment_876", "id": "reaction_10444914", "reactome": "R-DME-375140", "name": "CDO binds promyogenic cadherins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444877", "species_10444910" ], "products": [ "species_10444912" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VJB6", "FBgn0262018", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P18824", "arm", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388" ] }, "reaction_10450688": { "compartment": "compartment_7660", "id": "reaction_10450688", "reactome": "R-DME-448955", "name": "Phosphorylation of MEF2 proteins by p38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450672", "species_10450656", "species_29358" ], "products": [ "species_113582", "species_10450685" ], "modifiers": [ [ "species_10450672", "catalyst" ] ], "additional_components": [ "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "FBgn0011656", "P40791", "FBgn0011656", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846" ] }, "reaction_10445986": { "compartment": "compartment_7660", "id": "reaction_10445986", "reactome": "R-DME-381262", "name": "Formation of PPARG:RXRA heterodimer (ARF6 complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440428", "species_10445293" ], "products": [ "species_10445984" ], "modifiers": [], "additional_components": [ "FBgn0003964", "FBgn0000568", "P13055", "FBgn0000568", "P20153", "FBgn0003964" ] }, "reaction_10497719": { "compartment": "compartment_7660", "id": "reaction_10497719", "reactome": "R-DME-9624112", "name": "CEBPA binds CDK4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432391", "species_10497715" ], "products": [ "species_10497717" ], "modifiers": [], "additional_components": [ "FBgn0016131", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q7K306", "FBgn0016131" ] }, "reaction_10497723": { "compartment": "compartment_7660", "id": "reaction_10497723", "reactome": "R-DME-9624120", "name": "CEBPA binds CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427334", "species_10497715" ], "products": [ "species_10497721" ], "modifiers": [], "additional_components": [ "FBgn0004107", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "P23573", "FBgn0004107" ] }, "reaction_10497614": { "compartment": "compartment_7660", "id": "reaction_10497614", "reactome": "R-DME-9617067", "name": "All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497606", "species_5334804" ], "products": [ "species_10497612" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "species_5334816", "P13055", "FBgn0000568" ] }, "reaction_10430843": { "compartment": "compartment_70101", "id": "reaction_10430843", "reactome": "R-DME-72691", "name": "Formation of the 43S pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430839", "species_10430461" ], "products": [ "species_10430463" ], "modifiers": [], "additional_components": [ "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136" ] }, "reaction_10430537": { "compartment": "compartment_70101", "id": "reaction_10430537", "reactome": "R-DME-72669", "name": "Met-tRNAi binds to eIF2:GTP to form the ternary complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_72393", "species_10430459" ], "products": [ "species_10430461" ], "modifiers": [ [ "species_29438", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438" ] }, "reaction_10430535": { "compartment": "compartment_70101", "id": "reaction_10430535", "reactome": "R-DME-72663", "name": "De novo formation of eIF2:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10430457" ], "products": [ "species_10430459" ], "modifiers": [], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438" ] }, "reaction_10465097": { "compartment": "compartment_70101", "id": "reaction_10465097", "reactome": "R-DME-2161779", "name": "LXA4 is oxidised to 15k-LXA4 by HPGD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161759", "species_29360" ], "products": [ "species_70106", "species_2142761", "species_73473" ], "modifiers": [ [ "species_10465094", "catalyst" ] ], "additional_components": [ "Q9I7R3", "FBgn0042137" ] }, "reaction_10496834": { "compartment": "compartment_70101", "id": "reaction_10496834", "reactome": "R-DME-9018868", "name": "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9020583", "species_29450" ], "products": [ "species_29356", "species_9020474", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496829": { "compartment": "compartment_70101", "id": "reaction_10496829", "reactome": "R-DME-9018862", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9022655" ], "products": [ "species_9022660" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496973": { "compartment": "compartment_70101", "id": "reaction_10496973", "reactome": "R-DME-9023968", "name": "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9022660", "species_29360" ], "products": [ "species_9023963", "species_73473" ], "modifiers": [ [ "species_10465094", "catalyst" ] ], "additional_components": [ "Q9I7R3", "FBgn0042137" ] }, "reaction_10496836": { "compartment": "compartment_70101", "id": "reaction_10496836", "reactome": "R-DME-9018877", "name": "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9023708" ], "products": [ "species_9023712" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496838": { "compartment": "compartment_70101", "id": "reaction_10496838", "reactome": "R-DME-9018895", "name": "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9023653", "species_29450" ], "products": [ "species_29356", "species_9023651", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496848": { "compartment": "compartment_70101", "id": "reaction_10496848", "reactome": "R-DME-9020270", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024577" ], "products": [ "species_9024570" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:138615", "CHEBI:138616", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496850": { "compartment": "compartment_70101", "id": "reaction_10496850", "reactome": "R-DME-9020271", "name": "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024522" ], "products": [ "species_29356", "species_9024463", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496840": { "compartment": "compartment_70101", "id": "reaction_10496840", "reactome": "R-DME-9020252", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024602" ], "products": [ "species_9024574" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:138179", "CHEBI:138614", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10497011": { "compartment": "compartment_70101", "id": "reaction_10497011", "reactome": "R-DME-9027043", "name": "CYPs hydroxylate DHA to 14(R)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_9024011" ], "products": [ "species_29356", "species_29366", "species_9027049" ], "modifiers": [ [ "species_10432773", "catalyst" ] ], "additional_components": [ "Q95078", "FBgn0010383", "Q9VWR5", "FBgn0004959" ] }, "reaction_10496852": { "compartment": "compartment_70101", "id": "reaction_10496852", "reactome": "R-DME-9020273", "name": "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_9024012" ], "products": [ "species_29356", "species_9024815", "species_111745" ], "modifiers": [ [ "species_10496831", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10496842": { "compartment": "compartment_70101", "id": "reaction_10496842", "reactome": "R-DME-9020253", "name": "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024781" ], "products": [ "species_9024809" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:138649", "CHEBI:138648", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10497004": { "compartment": "compartment_70101", "id": "reaction_10497004", "reactome": "R-DME-9024766", "name": "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024764", "species_29360" ], "products": [ "species_9024799", "species_73473" ], "modifiers": [ [ "species_10465094", "catalyst" ] ], "additional_components": [ "CHEBI:132797", "CHEBI:132800", "Q9I7R3", "FBgn0042137" ] }, "reaction_10496846": { "compartment": "compartment_70101", "id": "reaction_10496846", "reactome": "R-DME-9020258", "name": "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024768" ], "products": [ "species_9024759" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "CHEBI:81565", "species_9024764", "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10496844": { "compartment": "compartment_70101", "id": "reaction_10496844", "reactome": "R-DME-9020257", "name": "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024893" ], "products": [ "species_9024879" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10497006": { "compartment": "compartment_70101", "id": "reaction_10497006", "reactome": "R-DME-9024890", "name": "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_9024873" ], "products": [ "species_9024886" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10450926": { "compartment": "compartment_70101", "id": "reaction_10450926", "reactome": "R-DME-450348", "name": "Activated human JNKs migrate to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437429" ], "products": [ "species_10437365" ], "modifiers": [], "additional_components": [] }, "reaction_10437443": { "compartment": "compartment_70101", "id": "reaction_10437443", "reactome": "R-DME-168162", "name": "Phosphorylation of human JNKs by activated MKK4/MKK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_10437429", "species_29370" ], "modifiers": [ [ "species_10437440", "catalyst" ] ], "additional_components": [ "FBgn0024326" ] }, "reaction_10450893": { "compartment": "compartment_70101", "id": "reaction_10450893", "reactome": "R-DME-450296", "name": "Phosphorylated MKK3/MKK6 migrates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450883" ], "products": [ "species_10450889" ], "modifiers": [], "additional_components": [ "FBgn0261524", "FBgn0261524" ] }, "reaction_10450918": { "compartment": "compartment_7660", "id": "reaction_10450918", "reactome": "R-DME-450333", "name": "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10450915" ], "products": [ "species_113582", "species_10450840" ], "modifiers": [ [ "species_10450889", "catalyst" ] ], "additional_components": [ "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "FBgn0261524" ] }, "reaction_10450853": { "compartment": "compartment_70101", "id": "reaction_10450853", "reactome": "R-DME-450257", "name": "Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450846" ], "products": [ "species_10450851" ], "modifiers": [], "additional_components": [ "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765" ] }, "reaction_10450849": { "compartment": "compartment_7660", "id": "reaction_10450849", "reactome": "R-DME-450222", "name": "Active p38 MAPK phosphorylates MAPKAPK2 or 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10450840" ], "products": [ "species_113582", "species_10450846" ], "modifiers": [ [ "species_10450840", "catalyst" ] ], "additional_components": [ "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P49071", "FBgn0013987" ] }, "reaction_10450876": { "compartment": "compartment_7660", "id": "reaction_10450876", "reactome": "R-DME-450292", "name": "Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450872", "species_10437390" ], "products": [ "species_10450874" ], "modifiers": [], "additional_components": [ "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550", "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550" ] }, "reaction_10437382": { "compartment": "compartment_7660", "id": "reaction_10437382", "reactome": "R-DME-168053", "name": "Phosphorylated MAPKs phosphorylate ATF-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437328", "species_29358" ], "products": [ "species_113582", "species_10437332" ], "modifiers": [ [ "species_10437379", "catalyst" ] ], "additional_components": [ "FBgn0265193", "FBgn0265193", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "P92208", "bsk" ] }, "reaction_10450901": { "compartment": "compartment_7660", "id": "reaction_10450901", "reactome": "R-DME-450325", "name": "c-FOS activation by phospho ERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10450899" ], "products": [ "species_113582", "species_10450872" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550", "P21525", "phospho-kay", "Q9XZS8", "FBgn0028550", "P40417", "FBgn0003256" ] }, "reaction_10437461": { "compartment": "compartment_7660", "id": "reaction_10437461", "reactome": "R-DME-168440", "name": "Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer. ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437332", "species_10437390" ], "products": [ "species_10437459" ], "modifiers": [], "additional_components": [ "FBgn0265193", "P18289", "phospho-Jra", "Q2PE13", "FBgn0265193" ] }, "reaction_10437393": { "compartment": "compartment_7660", "id": "reaction_10437393", "reactome": "R-DME-168136", "name": "Activated JNKs phosphorylate c-JUN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437386" ], "products": [ "species_113582", "species_10437390" ], "modifiers": [ [ "species_10437365", "catalyst" ] ], "additional_components": [] }, "reaction_10463567": { "compartment": "compartment_20699", "id": "reaction_10463567", "reactome": "R-DME-2022851", "name": "EXT1:EXT2 transfer GlcNAc to the heparan chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10463526" ], "products": [ "species_10463552", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10463662": { "compartment": "compartment_20699", "id": "reaction_10463662", "reactome": "R-DME-2022860", "name": "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10463622" ], "products": [ "species_10463648", "species_742343" ], "modifiers": [ [ "species_10463653", "catalyst" ] ], "additional_components": [ "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "FBgn0020251" ] }, "reaction_10464814": { "compartment": "compartment_20699", "id": "reaction_10464814", "reactome": "R-DME-2076419", "name": "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463809", "species_741440" ], "products": [ "species_742343", "species_10463831" ], "modifiers": [ [ "species_10464807", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "FBgn0038755" ] }, "reaction_10463596": { "compartment": "compartment_20699", "id": "reaction_10463596", "reactome": "R-DME-2022856", "name": "EXT1:EXT2 transfers GlcNAc to heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10463593" ], "products": [ "species_10463526", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10463691": { "compartment": "compartment_20699", "id": "reaction_10463691", "reactome": "R-DME-2022887", "name": "NDST1-4 N-deacetylates GlcNAc residues in heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2022884", "species_10463688" ], "products": [ "species_10463622", "species_2022890" ], "modifiers": [ [ "species_10463653", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "FBgn0020251" ] }, "reaction_10463947": { "compartment": "compartment_17963", "id": "reaction_10463947", "reactome": "R-DME-2024108", "name": "Some HSPGs are secreted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463833" ], "products": [ "species_10463945" ], "modifiers": [], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally" ] }, "reaction_10464822": { "compartment": "compartment_20699", "id": "reaction_10464822", "reactome": "R-DME-2076508", "name": "HS2ST1 sulfates IdoA at C2 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463731", "species_741440" ], "products": [ "species_742343", "species_10463757" ], "modifiers": [ [ "species_10464819", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "FBgn0024230" ] }, "reaction_10464836": { "compartment": "compartment_20699", "id": "reaction_10464836", "reactome": "R-DME-2076611", "name": "HS3STs sulfate GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10463757" ], "products": [ "species_742343", "species_10463783" ], "modifiers": [ [ "species_10464833", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "Q8MRE7", "FBgn0053147", "Q9VWJ7", "FBgn0031005" ] }, "reaction_10463699": { "compartment": "compartment_20699", "id": "reaction_10463699", "reactome": "R-DME-2022919", "name": "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463697", "species_914003" ], "products": [ "species_10463593", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10464802": { "compartment": "compartment_20699", "id": "reaction_10464802", "reactome": "R-DME-2076392", "name": "EXT1:EXT2 transfers GlcA to heparan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463552", "species_1889970" ], "products": [ "species_10463688", "species_205687" ], "modifiers": [ [ "species_10463564", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9Y169", "FBgn0029175", "Q9V730", "FBgn0265974" ] }, "reaction_10464800": { "compartment": "compartment_17963", "id": "reaction_10464800", "reactome": "R-DME-2076383", "name": "HS3ST1 sulfates GlcN at C3 in heparan sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10463757" ], "products": [ "species_742343", "species_10463783" ], "modifiers": [ [ "species_10464795", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "FBgn0053147" ] }, "reaction_10497796": { "compartment": "compartment_70101", "id": "reaction_10497796", "reactome": "R-DME-9630923", "name": "NFkB inhibitor binds NFkB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411", "species_10437415" ], "products": [ "species_10437417" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl" ] }, "reaction_10437457": { "compartment": "compartment_70101", "id": "reaction_10437457", "reactome": "R-DME-168166", "name": "NFkB complex is transported from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10468309": { "compartment": "compartment_7660", "id": "reaction_10468309", "reactome": "R-DME-3322427", "name": "Beta-catenin recruits CBP/p300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468258", "species_10447242" ], "products": [ "species_10468307" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0261617", "M9MS40", "FBgn0261617", "P18824", "arm", "Q8IMA8", "FBgn0085432" ] }, "reaction_10468260": { "compartment": "compartment_7660", "id": "reaction_10468260", "reactome": "R-DME-3299569", "name": "Beta-catenin displaces TLE:HDAC1 from TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468256", "species_10441673" ], "products": [ "species_10468258", "species_10457450", "species_10468252" ], "modifiers": [], "additional_components": [ "P16371", "GRO", "Q94517", "HDAC1", "Q8IMA8", "FBgn0085432", "P18824", "arm", "Q8IMA8", "FBgn0085432", "P16371", "GRO" ] }, "reaction_10468305": { "compartment": "compartment_7660", "id": "reaction_10468305", "reactome": "R-DME-3322424", "name": "Beta-catenin recruits CDC73 and LEO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434736", "species_10468258", "species_10434726" ], "products": [ "species_10468303" ], "modifiers": [], "additional_components": [ "FBgn0019637", "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0037657", "Q9VHI1", "FBgn0037657", "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q94546", "FBgn0019637" ] }, "reaction_10468464": { "compartment": "compartment_7660", "id": "reaction_10468464", "reactome": "R-DME-3364014", "name": "Recruitment of SET1 methyltransferase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468432", "species_10468437", "species_10465286", "species_10468442", "species_10468460" ], "products": [ "species_10468462" ], "modifiers": [], "additional_components": [ "FBgn0023518", "FBgn0000139", "FBgn0031885", "FBgn0036973", "Q9V9W8", "PYGO", "Q961D9", "LGS", "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q9VPH8", "FBgn0036973", "Q9V9W8", "PYGO", "Q961D9", "LGS", "P18824", "arm", "Q9VM47", "FBgn0031885", "Q94545", "FBgn0000139", "Q8IMA8", "FBgn0085432", "Q8IRW8", "FBgn0023518" ] }, "reaction_10441675": { "compartment": "compartment_70101", "id": "reaction_10441675", "reactome": "R-DME-201669", "name": "Beta-catenin translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440609" ], "products": [ "species_10441673" ], "modifiers": [], "additional_components": [] }, "reaction_10468687": { "compartment": "compartment_70101", "id": "reaction_10468687", "reactome": "R-DME-3640844", "name": "RNF146 binds RibC-AXIN:TNKS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468683", "species_10468669" ], "products": [ "species_10468685" ], "modifiers": [], "additional_components": [ "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "FBgn0036897", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn" ] }, "reaction_10468716": { "compartment": "compartment_70101", "id": "reaction_10468716", "reactome": "R-DME-3640874", "name": "Ub-RibC-AXIN is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468701" ], "products": [ "species_10468679", "species_10426987", "species_10468669" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "B7Z078", "FBgn0036897", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "FBgn0027508", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0036897", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10468694": { "compartment": "compartment_70101", "id": "reaction_10468694", "reactome": "R-DME-3640858", "name": "Tankyrase ADP-ribosylates AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468691", "species_29360" ], "products": [ "species_197277", "species_10468683" ], "modifiers": [ [ "species_10468691", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508" ] }, "reaction_10470006": { "compartment": "compartment_70101", "id": "reaction_10470006", "reactome": "R-DME-4641134", "name": "SMURF2 binds AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437960", "species_10440493" ], "products": [ "species_10469994" ], "modifiers": [], "additional_components": [ "FBgn0029006", "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006" ] }, "reaction_10470021": { "compartment": "compartment_70101", "id": "reaction_10470021", "reactome": "R-DME-4641256", "name": "Ubiquitinated AXIN is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470001" ], "products": [ "species_10437960", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006", "FBgn0029006", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10470004": { "compartment": "compartment_70101", "id": "reaction_10470004", "reactome": "R-DME-4641129", "name": "AXIN is ubiquitinated by SMURF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469994", "species_10426987" ], "products": [ "species_10470001" ], "modifiers": [ [ "species_10469994", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006", "Q9V407", "phospho-Axn", "Q9V853", "FBgn0029006" ] }, "reaction_10468706": { "compartment": "compartment_70101", "id": "reaction_10468706", "reactome": "R-DME-3640862", "name": "Tankyrase binds AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468679", "species_10440493" ], "products": [ "species_10468691" ], "modifiers": [], "additional_components": [ "FBgn0027508", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508" ] }, "reaction_10468704": { "compartment": "compartment_70101", "id": "reaction_10468704", "reactome": "R-DME-3640861", "name": "RNF146 ubiquitinates ADP-ribosylated AXIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10468685" ], "products": [ "species_10468701" ], "modifiers": [ [ "species_10468685", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "B7Z078", "FBgn0036897", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn" ] }, "reaction_10468714": { "compartment": "compartment_70101", "id": "reaction_10468714", "reactome": "R-DME-3640872", "name": "USP34 deubiquitinates AXIN1,AXIN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10468701" ], "products": [ "species_10426987", "species_10468685" ], "modifiers": [ [ "species_10468711", "catalyst" ] ], "additional_components": [ "B7Z078", "FBgn0036897", "Q9V407", "phospho-Axn", "Q9VBP3", "FBgn0027508", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "B7Z078", "FBgn0036897", "Q9VBP3", "FBgn0027508", "Q9V407", "phospho-Axn", "FBgn0039214" ] }, "reaction_10472015": { "compartment": "compartment_7660", "id": "reaction_10472015", "reactome": "R-DME-5368580", "name": "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441673", "species_10472011" ], "products": [ "species_10472013" ], "modifiers": [], "additional_components": [ "FBgn0266557", "B7Z002", "FBgn0266557", "P18824", "arm" ] }, "reaction_10475439": { "compartment": "compartment_7660", "id": "reaction_10475439", "reactome": "R-DME-5665608", "name": "TCF:Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468258", "species_10475435" ], "products": [ "species_10475437" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "P18824", "arm", "Q8IMA8", "FBgn0085432" ] }, "reaction_10468798": { "compartment": "compartment_7660", "id": "reaction_10468798", "reactome": "R-DME-3769391", "name": "XPO1 binds the beta-catenin:CBY complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468794", "species_10437629" ], "products": [ "species_10468796" ], "modifiers": [], "additional_components": [ "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta", "FBgn0020497", "Q9TVM2", "FBgn0020497", "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta" ] }, "reaction_10468427": { "compartment": "compartment_7660", "id": "reaction_10468427", "reactome": "R-DME-3361751", "name": "beta-catenin is replaced by repression complexes at the promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468421", "species_10468423" ], "products": [ "species_10468256", "species_10468425" ], "modifiers": [], "additional_components": [ "O46036", "FBgn0020496", "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P16371", "GRO", "Q94517", "HDAC1", "P16371", "GRO", "Q94517", "HDAC1", "Q8IMA8", "FBgn0085432", "O46036", "FBgn0020496", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589" ] }, "reaction_10468810": { "compartment": "compartment_7660", "id": "reaction_10468810", "reactome": "R-DME-3769394", "name": "AKT phosphorylates CBY1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10468785" ], "products": [ "species_113582", "species_10468792" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "B9A0M5", "FBgn0067317", "P18824", "arm", "P18824", "arm", "B9A0M5", "FBgn0067317" ] }, "reaction_10468345": { "compartment": "compartment_7660", "id": "reaction_10468345", "reactome": "R-DME-3322434", "name": "XIAP dissociates from ub-TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468338" ], "products": [ "species_10468336", "species_10468315" ], "modifiers": [], "additional_components": [ "Q24307", "Diap2", "Q24306", "Diap1", "P16371", "GRO", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10468808": { "compartment": "compartment_7660", "id": "reaction_10468808", "reactome": "R-DME-3769393", "name": "YWHAZ binds p-CBY:CTNNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451202", "species_10468792" ], "products": [ "species_10468794" ], "modifiers": [], "additional_components": [ "P18824", "arm", "B9A0M5", "FBgn0067317", "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta" ] }, "reaction_10468343": { "compartment": "compartment_7660", "id": "reaction_10468343", "reactome": "R-DME-3322431", "name": "XIAP binds TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468315", "species_10468252" ], "products": [ "species_10468317" ], "modifiers": [], "additional_components": [ "Q24307", "Diap2", "Q24306", "Diap1", "P16371", "GRO", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10468806": { "compartment": "compartment_70101", "id": "reaction_10468806", "reactome": "R-DME-3769392", "name": "YWHAZ and XPO1 mediate the nuclear export of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468796" ], "products": [ "species_10468804" ], "modifiers": [], "additional_components": [ "Q9TVM2", "FBgn0020497", "P18824", "arm", "B9A0M5", "FBgn0067317", "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "B9A0M5", "FBgn0067317", "P18824", "arm", "Q9TVM2", "FBgn0020497" ] }, "reaction_10468341": { "compartment": "compartment_7660", "id": "reaction_10468341", "reactome": "R-DME-3322429", "name": "XIAP monoubiquinates TLE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10468317" ], "products": [ "species_10468338" ], "modifiers": [ [ "species_10468317", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "P16371", "GRO", "P16371", "GRO", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10474292": { "compartment": "compartment_7660", "id": "reaction_10474292", "reactome": "R-DME-5626938", "name": "Beta-catenin binds SOX proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474288", "species_10441673" ], "products": [ "species_10474290" ], "modifiers": [], "additional_components": [ "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "Q9VA17", "FBgn0024288", "P18824", "arm", "Q24533", "FBgn0000411", "P40657", "FBgn0005613", "P40656", "FBgn0005612", "M9PFG6", "FBgn0036411", "M9PCZ7", "FBgn0029123", "M9PCG2", "FBgn0042630", "Q59DN5", "FBgn0039938", "Q9VA17", "FBgn0024288" ] }, "reaction_10468787": { "compartment": "compartment_7660", "id": "reaction_10468787", "reactome": "R-DME-3769383", "name": "CBY1 binds beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441673", "species_10468783" ], "products": [ "species_10468785" ], "modifiers": [], "additional_components": [ "FBgn0067317", "B9A0M5", "FBgn0067317", "P18824", "arm" ] }, "reaction_10441753": { "compartment": "compartment_876", "id": "reaction_10441753", "reactome": "R-DME-201677", "name": "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441725" ], "products": [ "species_29370", "species_10441750" ], "modifiers": [ [ "species_10441725", "catalyst" ] ], "additional_components": [ "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880", "P09615", "WG", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P18537", "FZ", "P51140", "phospho-dsh", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880", "Q9VLZ6", "FBgn0031926", "A1Z9D7", "FBgn0000119", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880" ] }, "reaction_10459892": { "compartment": "compartment_70101", "id": "reaction_10459892", "reactome": "R-DME-1504186", "name": "DVL recruits GSK3beta:AXIN1 to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441723", "species_10441677" ], "products": [ "species_10441725" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "P51140", "phospho-dsh", "P09615", "WG", "P18537", "FZ", "Q9VLZ6", "FBgn0031926", "Q8IQA9", "FBgn0035880", "Q4V6B0", "FBgn0033880" ] }, "reaction_10468814": { "compartment": "compartment_70101", "id": "reaction_10468814", "reactome": "R-DME-3772434", "name": "Phosphorylated DVL recruits PIP5K1B to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460946", "species_10441717" ], "products": [ "species_10468812" ], "modifiers": [], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984", "P51140", "phospho-dsh", "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10468824": { "compartment": "compartment_70101", "id": "reaction_10468824", "reactome": "R-DME-3772436", "name": "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10468812", "catalyst" ] ], "additional_components": [ "P51140", "phospho-dsh", "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10468821": { "compartment": "compartment_70101", "id": "reaction_10468821", "reactome": "R-DME-3772435", "name": "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441766" ], "products": [ "species_29370", "species_10441717" ], "modifiers": [ [ "species_10468818", "catalyst" ] ], "additional_components": [] }, "reaction_10441793": { "compartment": "compartment_70101", "id": "reaction_10441793", "reactome": "R-DME-201717", "name": "CSNK2-mediated phosphorylation of DVL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441759" ], "products": [ "species_29370", "species_10441766" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10471507": { "compartment": "compartment_984", "id": "reaction_10471507", "reactome": "R-DME-5323545", "name": "Canonical WNT signaling through the atypical receptor RYK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471501", "species_10471503" ], "products": [ "species_10471505" ], "modifiers": [], "additional_components": [ "FBgn0024245", "P09615", "WG", "P28466", "FBgn0010194", "P09615", "WG", "P28466", "FBgn0010194", "Q9V422", "FBgn0024245" ] }, "reaction_10470012": { "compartment": "compartment_70101", "id": "reaction_10470012", "reactome": "R-DME-4641155", "name": "DVL1 is bound by the HECT ubiquitin ligase HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470008", "species_10441759" ], "products": [ "species_10470010" ], "modifiers": [], "additional_components": [ "FBgn0261931", "P51140", "phospho-dsh", "Q9W326", "FBgn0261931" ] }, "reaction_10470023": { "compartment": "compartment_70101", "id": "reaction_10470023", "reactome": "R-DME-4641260", "name": "Ubiquitinated DVL1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470014" ], "products": [ "species_10470008", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9W326", "FBgn0261931", "P51140", "phospho-dsh", "FBgn0261931", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10459910": { "compartment": "compartment_70101", "id": "reaction_10459910", "reactome": "R-DME-1504190", "name": "DVL is ubiquitinated by CUL3:KLHL12:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459898", "species_10426987" ], "products": [ "species_10459907" ], "modifiers": [ [ "species_10459898", "catalyst" ] ], "additional_components": [ "Q8IP45", "FBgn0261268", "Q9W5E1", "Roc1a", "P51140", "phospho-dsh", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P51140", "phospho-dsh", "Q8IP45", "FBgn0261268", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9W5E1", "Roc1a", "P51140", "phospho-dsh" ] }, "reaction_10470017": { "compartment": "compartment_70101", "id": "reaction_10470017", "reactome": "R-DME-4641159", "name": "DVL1 is ubiquitinated by HECW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470010", "species_10426987" ], "products": [ "species_10470014" ], "modifiers": [ [ "species_10470010", "catalyst" ] ], "additional_components": [ "P51140", "phospho-dsh", "Q9W326", "FBgn0261931", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W326", "FBgn0261931", "P51140", "phospho-dsh", "P51140", "phospho-dsh", "Q9W326", "FBgn0261931" ] }, "reaction_10496688": { "compartment": "compartment_876", "id": "reaction_10496688", "reactome": "R-DME-9018768", "name": "RHOU auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496685" ], "products": [ "species_29420", "species_10496660" ], "modifiers": [ [ "species_10496685", "catalyst" ] ], "additional_components": [ "Q0KHU4", "FBgn0083940", "species_29420", "Q0KHU4", "FBgn0083940", "species_29438", "Q0KHU4", "FBgn0083940", "species_29420" ] }, "reaction_10496683": { "compartment": "compartment_876", "id": "reaction_10496683", "reactome": "R-DME-9018766", "name": "RHOU binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496679", "species_10496660" ], "products": [ "species_10496681" ], "modifiers": [], "additional_components": [ "Q9VXE5", "FBgn0025743", "Q9VIS1", "FBgn0032821", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698", "Q0KHU4", "FBgn0083940", "species_29438", "Q0KHU4", "FBgn0083940", "species_29438", "Q9VXE5", "FBgn0025743", "Q9VIS1", "FBgn0032821", "Q9VPU1", "dock", "B7Z0W0", "FBgn0267698" ] }, "reaction_10496403": { "compartment": "compartment_876", "id": "reaction_10496403", "reactome": "R-DME-9013147", "name": "RAC1 GDIs block activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464321", "species_10440312" ], "products": [ "species_10496401" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29420", "Q9VW59", "RhoGDI" ] }, "reaction_10496358": { "compartment": "compartment_876", "id": "reaction_10496358", "reactome": "R-DME-9013144", "name": "RAC1 GAPs stimulate RAC1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067", "species_29356" ], "products": [ "species_10464321", "species_29372" ], "modifiers": [ [ "species_10496355", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29420", "Q9VWL7", "FBgn0261461", "X2JEI9", "FBgn0031118", "Q9VDS5", "FBgn0038747", "Q9VDG2", "FBgn0026056", "Q0E938", "FBgn0028494", "Q9VIS1", "FBgn0032821", "Q9W4A9", "FBgn0029778", "Q9V9S7", "FBgn0039883", "Q9VDE9", "RhoGAP93B", "B7Z058", "FBgn0036518" ] }, "reaction_10496311": { "compartment": "compartment_876", "id": "reaction_10496311", "reactome": "R-DME-9013143", "name": "RAC1 GEFs activate RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10464321" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10496308", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "P25157", "FBgn0000384", "Q9VAS8", "FBgn0264324", "Q9NHV9", "FBgn0040068", "P91621", "FBgn0085447" ] }, "reaction_10498558": { "compartment": "compartment_876", "id": "reaction_10498558", "reactome": "R-DME-9691168", "name": "RAC1 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067" ], "products": [ "species_10498556" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10496399": { "compartment": "compartment_876", "id": "reaction_10496399", "reactome": "R-DME-9013145", "name": "RAC1 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351067", "species_10496395" ], "products": [ "species_10496397" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "O97111", "FBgn0026192", "B7YZT5", "FBgn0286511", "B7Z0W0", "FBgn0267698", "A1Z7T0", "FBgn0020621", "Q9W1B0", "FBgn0023081", "Q8IQE6", "FBgn0052082", "Q7K490", "FBgn0033996", "Q9VXE5", "FBgn0025743", "M9PE53", "FBgn0264272", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "Q9VF87", "FBgn0038320", "O97111", "FBgn0026192", "B7YZT5", "FBgn0286511", "B7Z0W0", "FBgn0267698", "A1Z7T0", "FBgn0020621", "Q9W1B0", "FBgn0023081", "Q8IQE6", "FBgn0052082", "Q7K490", "FBgn0033996", "Q9VXE5", "FBgn0025743", "M9PE53", "FBgn0264272", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10498562": { "compartment": "compartment_876", "id": "reaction_10498562", "reactome": "R-DME-9692800", "name": "CDC42 translocates to the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439139" ], "products": [ "species_10498560" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "P40793", "FBgn0010341", "species_29438" ] }, "reaction_10496452": { "compartment": "compartment_876", "id": "reaction_10496452", "reactome": "R-DME-9013161", "name": "CDC42 GAPs stimulate CDC42 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10439139" ], "products": [ "species_29372", "species_10496432" ], "modifiers": [ [ "species_10496449", "catalyst" ] ], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "species_29420", "P40793", "FBgn0010341", "Q9VX92", "FBgn0030808", "Q9VDE9", "RhoGAP93B", "Q8T0G4", "FBgn0039994", "Q9VTU3", "FBgn0036257", "B7Z058", "FBgn0036518", "Q0E938", "FBgn0028494" ] }, "reaction_10496438": { "compartment": "compartment_876", "id": "reaction_10496438", "reactome": "R-DME-9013158", "name": "CDC42 GDIs block activation of CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440312", "species_10496432" ], "products": [ "species_10496436" ], "modifiers": [], "additional_components": [ "species_29420", "P40793", "FBgn0010341", "P40793", "FBgn0010341", "species_29420", "Q9VW59", "RhoGDI" ] }, "reaction_10496445": { "compartment": "compartment_876", "id": "reaction_10496445", "reactome": "R-DME-9013159", "name": "CDC42 GEFs activate CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496432" ], "products": [ "species_29420", "species_10439139" ], "modifiers": [ [ "species_10496442", "catalyst" ] ], "additional_components": [ "species_29420", "P40793", "FBgn0010341", "species_29438", "P40793", "FBgn0010341", "P25157", "FBgn0000384", "A1ZBA1", "FBgn0050115", "Q9W0S2", "FBgn0264707", "Q9VVC6", "FBgn0261547", "Q7KU89", "FBgn0035802", "Q7K4E0", "FBgn0050440" ] }, "reaction_10498596": { "compartment": "compartment_876", "id": "reaction_10498596", "reactome": "R-DME-9693125", "name": "RHOF binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498572", "species_10498592" ], "products": [ "species_10498594" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "A8JQT5", "FBgn0265082", "P48608", "FBgn0011202", "Q8IQE6", "FBgn0052082", "A8JQT5", "FBgn0265082", "P48608", "FBgn0011202", "Q8IQE6", "FBgn0052082", "P48148", "Rho1", "species_29438" ] }, "reaction_10498649": { "compartment": "compartment_876", "id": "reaction_10498649", "reactome": "R-DME-9693282", "name": "RHOF GAPs stimulate RHOF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10498572" ], "products": [ "species_29372", "species_10498570" ], "modifiers": [ [ "species_10498646", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29438", "species_29420", "P48148", "Rho1", "Q9VTU3", "FBgn0036257" ] }, "reaction_10498575": { "compartment": "compartment_876", "id": "reaction_10498575", "reactome": "R-DME-9693111", "name": "RHOF auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10498570" ], "products": [ "species_29420", "species_10498572" ], "modifiers": [ [ "species_10498570", "catalyst" ] ], "additional_components": [ "species_29420", "P48148", "Rho1", "P48148", "Rho1", "species_29438", "species_29420", "P48148", "Rho1" ] }, "reaction_10496723": { "compartment": "compartment_876", "id": "reaction_10496723", "reactome": "R-DME-9018778", "name": "RHOBTB1 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496719", "species_10496695" ], "products": [ "species_10496721" ], "modifiers": [], "additional_components": [ "Q9VJ79", "FBgn0085370", "Q9VFI9", "FBgn0038237", "Q9VXE3", "FBgn0026181", "Q8IP45", "FBgn0261268", "M9PG08", "FBgn0036980", "species_29438", "M9PG08", "FBgn0036980", "species_29438", "Q9VJ79", "FBgn0085370", "Q9VFI9", "FBgn0038237", "Q9VXE3", "FBgn0026181", "Q8IP45", "FBgn0261268" ] }, "reaction_10496697": { "compartment": "compartment_74700", "id": "reaction_10496697", "reactome": "R-DME-9018774", "name": "RHOBTB1 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496693" ], "products": [ "species_10496695" ], "modifiers": [], "additional_components": [ "FBgn0036980", "M9PG08", "FBgn0036980", "species_29438" ] }, "reaction_10496752": { "compartment": "compartment_74700", "id": "reaction_10496752", "reactome": "R-DME-9018787", "name": "RHOBTB2 binds interacting proteins at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496748", "species_10496727" ], "products": [ "species_10496750" ], "modifiers": [], "additional_components": [ "Q9VVE5", "FBgn0260943", "Q8IP45", "FBgn0261268", "M9PG08", "FBgn0036980", "species_29438", "M9PG08", "FBgn0036980", "species_29438", "Q9VVE5", "FBgn0260943", "Q8IP45", "FBgn0261268" ] }, "reaction_10496732": { "compartment": "compartment_70101", "id": "reaction_10496732", "reactome": "R-DME-9018785", "name": "RHOBTB2 binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496725" ], "products": [ "species_10496727" ], "modifiers": [ [ "species_10496729", "catalyst" ] ], "additional_components": [ "FBgn0036980", "M9PG08", "FBgn0036980", "species_29438", "P02828", "FBgn0001233", "Q24276", "FBgn0011573" ] }, "reaction_10496496": { "compartment": "compartment_876", "id": "reaction_10496496", "reactome": "R-DME-9013452", "name": "RHOD:GTP translocates to the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460" ], "products": [ "species_10475550" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438" ] }, "reaction_10498627": { "compartment": "compartment_876", "id": "reaction_10498627", "reactome": "R-DME-9693243", "name": "RHOD translocates to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460" ], "products": [ "species_10498625" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "species_29438", "P48148", "Rho1" ] }, "reaction_10496468": { "compartment": "compartment_876", "id": "reaction_10496468", "reactome": "R-DME-9013437", "name": "RHOD GAPs stimulate RHOD GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496460" ], "products": [ "species_29372", "species_10496456" ], "modifiers": [ [ "species_10496465", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420", "Q9VIS1", "FBgn0032821", "Q9VX32", "RhoGAPp190", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685" ] }, "reaction_10498644": { "compartment": "compartment_20699", "id": "reaction_10498644", "reactome": "R-DME-9693250", "name": "RHOD binds effectors at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498625", "species_10498640" ], "products": [ "species_10498642" ], "modifiers": [], "additional_components": [ "species_29438", "P48148", "Rho1", "Q8SX68", "FBgn0034308", "Q8SX68", "FBgn0034308", "species_29438", "P48148", "Rho1" ] }, "reaction_10498613": { "compartment": "compartment_876", "id": "reaction_10498613", "reactome": "R-DME-9693207", "name": "RHOD translocates to the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460" ], "products": [ "species_10498611" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438" ] }, "reaction_10498621": { "compartment": "compartment_17906", "id": "reaction_10498621", "reactome": "R-DME-9693214", "name": "RHOD binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498617", "species_10498611" ], "products": [ "species_10498619" ], "modifiers": [], "additional_components": [ "Q9VXE5", "FBgn0025743", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "Q9VXE5", "FBgn0025743" ] }, "reaction_10496494": { "compartment": "compartment_876", "id": "reaction_10496494", "reactome": "R-DME-9013438", "name": "RHOD binds effectors at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496490", "species_10475550" ], "products": [ "species_10496492" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "Q9VPY3", "FBgn0031317", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "Q9VPY3", "FBgn0031317" ] }, "reaction_10496463": { "compartment": "compartment_876", "id": "reaction_10496463", "reactome": "R-DME-9013435", "name": "RHOD auto-activates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496456" ], "products": [ "species_29420", "species_10496460" ], "modifiers": [ [ "species_10496456", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420" ] }, "reaction_10498607": { "compartment": "compartment_70101", "id": "reaction_10498607", "reactome": "R-DME-9693198", "name": "RHOD binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496460", "species_10498603" ], "products": [ "species_10498605" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "P48603", "FBgn0011570", "Q9VDE9", "RhoGAP93B", "Q9VJ26", "FBgn0032731", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P18091", "FBgn0000667", "Q02645", "FBgn0263391", "O76742", "FBgn0015795", "Q9VU84", "FBgn0036372", "P08928", "FBgn0002525", "Q8IPI3", "FBgn0259111", "Q9VTU3", "FBgn0036257", "Q9VW40", "FBgn0036908", "P48608", "FBgn0011202", "P48603", "FBgn0011570", "Q9VDE9", "RhoGAP93B", "Q9VJ26", "FBgn0032731", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P18091", "FBgn0000667", "Q02645", "FBgn0263391", "O76742", "FBgn0015795", "Q9VU84", "FBgn0036372", "P08928", "FBgn0002525", "Q8IPI3", "FBgn0259111", "Q9VTU3", "FBgn0036257", "Q9VW40", "FBgn0036908", "P48148", "Rho1", "species_29438" ] }, "reaction_10496514": { "compartment": "compartment_70101", "id": "reaction_10496514", "reactome": "R-DME-9014293", "name": "RAC2 GDIs block activation of RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496508", "species_10440312" ], "products": [ "species_10496512" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29420", "Q9VW59", "RhoGDI", "species_29420", "P48554", "FBgn0014011", "P40792", "RAC1_DROME" ] }, "reaction_10496532": { "compartment": "compartment_70101", "id": "reaction_10496532", "reactome": "R-DME-9014296", "name": "RAC2 GEFs activate RAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496508" ], "products": [ "species_10434896", "species_29420" ], "modifiers": [ [ "species_10496529", "catalyst" ] ], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29420", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "X2JC00", "FBgn0025836", "Q9NHV9", "FBgn0040068", "Q7K4E0", "FBgn0050440", "P91621", "FBgn0085447" ] }, "reaction_10496534": { "compartment": "compartment_876", "id": "reaction_10496534", "reactome": "R-DME-9014420", "name": "RAC2 translocates to the phagocytic vesicle membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896" ], "products": [ "species_10475589" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10498823": { "compartment": "compartment_876", "id": "reaction_10498823", "reactome": "R-DME-9714483", "name": "RAC2 translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896" ], "products": [ "species_10498821" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10496522": { "compartment": "compartment_70101", "id": "reaction_10496522", "reactome": "R-DME-9014294", "name": "RAC2 binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896", "species_10496518" ], "products": [ "species_10496520" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "B7YZT5", "FBgn0286511", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "B7YZT5", "FBgn0286511", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10498813": { "compartment": "compartment_17906", "id": "reaction_10498813", "reactome": "R-DME-9714477", "name": "RAC2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498797", "species_10498809" ], "products": [ "species_10498811" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496527": { "compartment": "compartment_70101", "id": "reaction_10496527", "reactome": "R-DME-9014295", "name": "RAC2 GAPs stimulate RAC2 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896", "species_29356" ], "products": [ "species_29372", "species_10496508" ], "modifiers": [ [ "species_10496524", "catalyst" ] ], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29420", "Q9VX32", "RhoGAPp190", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685" ] }, "reaction_10498815": { "compartment": "compartment_876", "id": "reaction_10498815", "reactome": "R-DME-9714480", "name": "RAC2 translocates to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434896" ], "products": [ "species_10498797" ], "modifiers": [], "additional_components": [ "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496786": { "compartment": "compartment_876", "id": "reaction_10496786", "reactome": "R-DME-9018794", "name": "RHOV binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496782", "species_10496756" ], "products": [ "species_10496784" ], "modifiers": [], "additional_components": [ "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "Q0KHU4", "FBgn0083940", "species_29438", "Q0KHU4", "FBgn0083940", "species_29438", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698" ] }, "reaction_10496790": { "compartment": "compartment_876", "id": "reaction_10496790", "reactome": "R-DME-9018798", "name": "RHOV binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496788" ], "products": [ "species_29420", "species_10496756" ], "modifiers": [], "additional_components": [ "Q0KHU4", "FBgn0083940", "species_29420", "Q0KHU4", "FBgn0083940", "species_29438" ] }, "reaction_10495680": { "compartment": "compartment_70101", "id": "reaction_10495680", "reactome": "R-DME-8981637", "name": "RHOA GAPs stimulate RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10434906" ], "products": [ "species_29372", "species_10434904" ], "modifiers": [ [ "species_10495677", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420", "X2JDY8", "FBgn0030685", "Q9VX32", "RhoGAPp190", "Q8T0G4", "FBgn0039994", "A1ZAW3", "FBgn0034249", "H9XVN1", "FBgn0259216", "Q9VIS1", "FBgn0032821", "B7Z058", "FBgn0036518", "Q9VTU3", "FBgn0036257", "A8JR05", "FBgn0285955" ] }, "reaction_10496244": { "compartment": "compartment_70101", "id": "reaction_10496244", "reactome": "R-DME-9012835", "name": "GDIs block activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440312", "species_10434904" ], "products": [ "species_10496242" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29420", "Q9VW59", "RhoGDI" ] }, "reaction_10496248": { "compartment": "compartment_876", "id": "reaction_10496248", "reactome": "R-DME-9013006", "name": "RHOA:GTP translocates to the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434906" ], "products": [ "species_10496246" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438" ] }, "reaction_10495532": { "compartment": "compartment_70101", "id": "reaction_10495532", "reactome": "R-DME-8980691", "name": "RHOA GEFs activate RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10495529", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "M9PBE1", "FBgn0032796", "Q9VVC6", "FBgn0261547", "Q8IQ97", "FBgn0003041", "Q9NHV9", "FBgn0040068", "A1ZAN6", "FBgn0023172", "M9PHU0", "FBgn0263706", "Q7K4E0", "FBgn0050440", "Q9VW85", "FBgn0261556", "Q7KVD1", "FBgn0024277" ] }, "reaction_10496302": { "compartment": "compartment_876", "id": "reaction_10496302", "reactome": "R-DME-9013009", "name": "RHOA binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496298", "species_10434906" ], "products": [ "species_10496300" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "B7YZT5", "FBgn0286511", "Q9XYY9", "FBgn0026374", "Q9W179", "FBgn0035001", "A1Z7T0", "FBgn0020621", "Q9VXE3", "FBgn0026181", "Q9V4P1", "FBgn0261385", "M9MSM5", "FBgn0025641", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "B7YZT5", "FBgn0286511", "Q9XYY9", "FBgn0026374", "Q9W179", "FBgn0035001", "A1Z7T0", "FBgn0020621", "Q9VXE3", "FBgn0026181", "Q9V4P1", "FBgn0261385", "M9MSM5", "FBgn0025641" ] }, "reaction_10496569": { "compartment": "compartment_876", "id": "reaction_10496569", "reactome": "R-DME-9017488", "name": "RHOJ GAPs stimulate RHOJ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496562" ], "products": [ "species_29372", "species_10496564" ], "modifiers": [ [ "species_10496566", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "P40793", "FBgn0010341", "species_29420", "Q9VX32", "RhoGAPp190", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685" ] }, "reaction_10496572": { "compartment": "compartment_876", "id": "reaction_10496572", "reactome": "R-DME-9017491", "name": "RHOJ GEFs activate RHOJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496564" ], "products": [ "species_29420", "species_10496562" ], "modifiers": [ [ "species_10457618", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "species_29420", "P40793", "FBgn0010341", "species_29438", "FBgn0031216" ] }, "reaction_10496609": { "compartment": "compartment_70101", "id": "reaction_10496609", "reactome": "R-DME-9018746", "name": "RHOQ binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496591", "species_10496605" ], "products": [ "species_10496607" ], "modifiers": [], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "Q9VIS1", "FBgn0032821", "A8JNK4", "FBgn0035533", "B7Z0W0", "FBgn0267698", "Q9VIS1", "FBgn0032821", "A8JNK4", "FBgn0035533", "B7Z0W0", "FBgn0267698", "P40793", "FBgn0010341", "species_29438" ] }, "reaction_10496614": { "compartment": "compartment_876", "id": "reaction_10496614", "reactome": "R-DME-9018747", "name": "RHOQ GEFs activate RHOQ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496593" ], "products": [ "species_10496591", "species_29420" ], "modifiers": [ [ "species_10496611", "catalyst" ] ], "additional_components": [ "species_29420", "P40793", "FBgn0010341", "P40793", "FBgn0010341", "species_29438", "M9ND00", "FBgn0023388" ] }, "reaction_10496598": { "compartment": "compartment_70101", "id": "reaction_10496598", "reactome": "R-DME-9018745", "name": "RHOQ GAPs stimulate RHOQ GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496591", "species_29356" ], "products": [ "species_29372", "species_10496593" ], "modifiers": [ [ "species_10496595", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "species_29420", "P40793", "FBgn0010341", "Q9VTU3", "FBgn0036257", "X2JDY8", "FBgn0030685", "A8JR05", "FBgn0285955" ] }, "reaction_10496826": { "compartment": "compartment_876", "id": "reaction_10496826", "reactome": "R-DME-9018836", "name": "RHOQ translocates to the Golgi-associated vesicle membranes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496591" ], "products": [ "species_10496824" ], "modifiers": [], "additional_components": [ "P40793", "FBgn0010341", "species_29438", "P40793", "FBgn0010341", "species_29438" ] }, "reaction_10496626": { "compartment": "compartment_876", "id": "reaction_10496626", "reactome": "R-DME-9018754", "name": "GDIs bind RHOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496622", "species_10440312" ], "products": [ "species_10496624" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "Q9VW59", "RhoGDI", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496628": { "compartment": "compartment_876", "id": "reaction_10496628", "reactome": "R-DME-9018756", "name": "RHOH binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10496620" ], "products": [ "species_10496622" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10496653": { "compartment": "compartment_876", "id": "reaction_10496653", "reactome": "R-DME-9018758", "name": "RHOH binds effectors at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496622", "species_10496649" ], "products": [ "species_10496651" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9VXE5", "FBgn0025743", "B7Z0W0", "FBgn0267698", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438" ] }, "reaction_10455477": { "compartment": "compartment_20699", "id": "reaction_10455477", "reactome": "R-DME-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_915149" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10455474", "catalyst" ] ], "additional_components": [ "P53624", "FBgn0259170", "Q8IMK0", "FBgn0051202" ] }, "reaction_10455523": { "compartment": "compartment_20699", "id": "reaction_10455523", "reactome": "R-DME-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964828" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10455474", "catalyst" ] ], "additional_components": [ "P53624", "FBgn0259170", "Q8IMK0", "FBgn0051202" ] }, "reaction_10455521": { "compartment": "compartment_20699", "id": "reaction_10455521", "reactome": "R-DME-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964831" ], "products": [ "species_964752", "species_964740" ], "modifiers": [ [ "species_10455474", "catalyst" ] ], "additional_components": [ "CHEBI:60629", "CHEBI:60628", "CHEBI:60627", "P53624", "FBgn0259170", "Q8IMK0", "FBgn0051202" ] }, "reaction_10461309": { "compartment": "compartment_161320", "id": "reaction_10461309", "reactome": "R-DME-1678742", "name": "NAGLU hydrolyses Heparan sulfate chain(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090069" ], "products": [ "species_2090080", "species_1678743" ], "modifiers": [ [ "species_10461306", "catalyst" ] ], "additional_components": [ "FBgn0014417" ] }, "reaction_10464861": { "compartment": "compartment_17938", "id": "reaction_10464861", "reactome": "R-DME-2090085", "name": "HGSNAT oligomer acetylates Heparan chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_2090045" ], "products": [ "species_2090053", "species_76194" ], "modifiers": [ [ "species_10461235", "catalyst" ] ], "additional_components": [ "Q9W4F7", "FBgn0029737" ] }, "reaction_10464859": { "compartment": "compartment_161320", "id": "reaction_10464859", "reactome": "R-DME-2090079", "name": "GLB1 hydrolyses linker chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090075" ], "products": [ "species_1605637", "species_2090063" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_10463705": { "compartment": "compartment_876", "id": "reaction_10463705", "reactome": "R-DME-2024084", "name": "HS-GAGs translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461260" ], "products": [ "species_10460901" ], "modifiers": [], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "Q24114", "dally" ] }, "reaction_10464857": { "compartment": "compartment_161320", "id": "reaction_10464857", "reactome": "R-DME-2090043", "name": "SGSH hydrolyses Heparan sulfate chain(7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090070" ], "products": [ "species_1606845", "species_2090045" ], "modifiers": [ [ "species_10461290", "catalyst" ] ], "additional_components": [ "FBgn0038660" ] }, "reaction_10464855": { "compartment": "compartment_161320", "id": "reaction_10464855", "reactome": "R-DME-2090038", "name": "NAGLU hydrolyses heparan chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090053" ], "products": [ "species_1678743", "species_2065212" ], "modifiers": [ [ "species_10461306", "catalyst" ] ], "additional_components": [ "FBgn0014417" ] }, "reaction_10461238": { "compartment": "compartment_17938", "id": "reaction_10461238", "reactome": "R-DME-1678660", "name": "HGSNAT oligomer acetylates Heparan sulfate chain(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090040", "species_76183" ], "products": [ "species_2090069", "species_76194" ], "modifiers": [ [ "species_10461235", "catalyst" ] ], "additional_components": [ "Q9W4F7", "FBgn0029737" ] }, "reaction_10461301": { "compartment": "compartment_161320", "id": "reaction_10461301", "reactome": "R-DME-1678716", "name": "IDUA hydrolyses Heparan sulfate chain(1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090033", "species_1605715" ], "products": [ "species_2090072", "species_1678617" ], "modifiers": [ [ "species_10461298", "catalyst" ] ], "additional_components": [ "FBgn0032343" ] }, "reaction_10464853": { "compartment": "compartment_161320", "id": "reaction_10464853", "reactome": "R-DME-2090037", "name": "IDUA hydrolyses Heparan sulfate chain(6)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090055" ], "products": [ "species_2090070", "species_1678617" ], "modifiers": [ [ "species_10461298", "catalyst" ] ], "additional_components": [ "FBgn0032343" ] }, "reaction_10461293": { "compartment": "compartment_161320", "id": "reaction_10461293", "reactome": "R-DME-1678708", "name": "SGSH hydrolyses Heparan sulfate chain(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2090072" ], "products": [ "species_2090040", "species_1606845" ], "modifiers": [ [ "species_10461290", "catalyst" ] ], "additional_components": [ "FBgn0038660" ] }, "reaction_10461228": { "compartment": "compartment_161320", "id": "reaction_10461228", "reactome": "R-DME-1678650", "name": "IDS hydrolyses Heparan sulfate chain(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2090080", "species_1605715" ], "products": [ "species_2090055", "species_1606845" ], "modifiers": [ [ "species_10461225", "catalyst" ] ], "additional_components": [ "Q9VZP8", "FBgn0035445", "species_74016" ] }, "reaction_10460935": { "compartment": "compartment_161320", "id": "reaction_10460935", "reactome": "R-DME-1667005", "name": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_10460901" ], "products": [ "species_2090033", "species_10460923" ], "modifiers": [ [ "species_10460932", "catalyst" ] ], "additional_components": [ "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "Q24114", "dally", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VE79", "FBgn0038611" ] }, "reaction_10461351": { "compartment": "compartment_161320", "id": "reaction_10461351", "reactome": "R-DME-1678854", "name": "GUSB tetramer hydrolyses CS/HS precursor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065212" ], "products": [ "species_1678868", "species_2090075" ], "modifiers": [ [ "species_10461348", "catalyst" ], [ "species_427963", "inhibitor" ] ], "additional_components": [ "A1ZBG9", "FBgn0034417" ] }, "reaction_10461285": { "compartment": "compartment_876", "id": "reaction_10461285", "reactome": "R-DME-1678694", "name": "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10461260" ], "products": [ "species_10461280", "species_2090023" ], "modifiers": [ [ "species_10461282", "catalyst" ] ], "additional_components": [ "Q24114", "dally", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VUG1", "FBgn0041604", "FBgn0038611" ] }, "reaction_10496818": { "compartment": "compartment_70101", "id": "reaction_10496818", "reactome": "R-DME-9018824", "name": "RHOT2 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496814", "species_10496796" ], "products": [ "species_10496816" ], "modifiers": [], "additional_components": [ "Q960V3", "FBgn0262872", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "Q8IMX7", "Miro", "species_29438", "Q8IMX7", "Miro", "species_29438", "Q960V3", "FBgn0262872", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596" ] }, "reaction_10496820": { "compartment": "compartment_70101", "id": "reaction_10496820", "reactome": "R-DME-9018826", "name": "RHOT2 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496796" ], "products": [ "species_10496798", "species_29372" ], "modifiers": [ [ "species_10496796", "catalyst" ] ], "additional_components": [ "Q8IMX7", "Miro", "species_29438", "Q8IMX7", "Miro", "species_29420", "Q8IMX7", "Miro", "species_29438" ] }, "reaction_10448207": { "compartment": "compartment_20699", "id": "reaction_10448207", "reactome": "R-DME-426015", "name": "Na+/H+ exchanger transport (at trans-golgi membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425969", "species_83910" ], "products": [ "species_70106", "species_425958" ], "modifiers": [ [ "species_10448204", "catalyst" ] ], "additional_components": [ "Q9VPJ1", "FBgn0026787", "Q8IPJ4", "FBgn0028703" ] }, "reaction_10448172": { "compartment": "compartment_172574", "id": "reaction_10448172", "reactome": "R-DME-425965", "name": "SLC9A9 exchanges Na+ for H+ across the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425999", "species_83910" ], "products": [ "species_425977", "species_70106" ], "modifiers": [ [ "species_10448169", "catalyst" ] ], "additional_components": [ "FBgn0028703" ] }, "reaction_10448195": { "compartment": "compartment_876", "id": "reaction_10448195", "reactome": "R-DME-425994", "name": "Na+/H+ exchanger transport (at cell membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10448184", "catalyst" ] ], "additional_components": [ "FBgn0040297" ] }, "reaction_10448179": { "compartment": "compartment_171062", "id": "reaction_10448179", "reactome": "R-DME-425983", "name": "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425978", "species_83910" ], "products": [ "species_70106", "species_425971" ], "modifiers": [ [ "species_10448174", "catalyst" ] ], "additional_components": [ "FBgn0028703" ] }, "reaction_209074": { "compartment": "compartment_984", "id": "reaction_209074", "reactome": "R-DME-209074", "name": "WG, FZ and ARR bind to each other", "reversible": "false", "notes": "The extracellular ligand Wingless (WG) binds to the extracellular domains of the plasma membrane Frizzled (FZ/FZ2) and Arrow (ARR) receptors. Both of these transmembrane receptors additionally interact with each other.", "reactants": [ "species_206202", "species_205797", "species_206546" ], "products": [ "species_206872" ], "modifiers": [], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR" ] }, "reaction_209108": { "compartment": "compartment_876", "id": "reaction_209108", "reactome": "R-DME-209108", "name": "Membrane-bound GISH binds to ARR receptor complex", "reversible": "false", "notes": "The plasma membrane tethered CKIgamma orthologue, GISH, complexes with the cytoplasmic tail of Arrow (ARR).", "reactants": [ "species_205695", "species_206872" ], "products": [ "species_206907" ], "modifiers": [], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH" ] }, "reaction_209135": { "compartment": "compartment_70101", "id": "reaction_209135", "reactome": "R-DME-209135", "name": "GISH further phosphorylates ARR in the receptor complex", "reversible": "false", "notes": "The bound kinase GISH phosphorylates two further residues on Arrow's (ARR) tail. Thr1493 and Thr1479 in Human LRP6 are phosphorylated by CKIgamma.", "reactants": [ "species_113592", "species_206800" ], "products": [ "species_29370", "species_206613" ], "modifiers": [ [ "species_206800", "catalyst" ] ], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "Q95V09", "ARR", "P09615", "WG", "Q86BR9", "GISH", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P18537", "FZ", "Q9VVX3", "FZ2", "Q95V09", "ARR", "P09615", "WG", "Q86BR9", "GISH" ] }, "reaction_209118": { "compartment": "compartment_70101", "id": "reaction_209118", "reactome": "R-DME-209118", "name": "Membrane localised SGG phosphorylates ARR", "reversible": "false", "notes": "The resulting transmembrane co-receptor complex is now primed for phosphorylation on the C-terminal tail of Arrow (ARR) by a membrane localised Shaggy (SGG). Ser1490 in Human LRP6 is phosphorylated by GSK3beta.", "reactants": [ "species_113592", "species_206907" ], "products": [ "species_29370", "species_206800" ], "modifiers": [ [ "species_5263693", "catalyst" ] ], "additional_components": [ "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P18537", "FZ", "Q9VVX3", "FZ2", "Q95V09", "ARR", "P09615", "WG", "Q86BR9", "GISH" ] }, "reaction_10481336": { "compartment": "compartment_876", "id": "reaction_10481336", "reactome": "R-DME-6798258", "name": "PRTPRF, PTPRS, PTPRD bind LRRC4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481332", "species_10446397" ], "products": [ "species_10481334" ], "modifiers": [], "additional_components": [ "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "FBgn0000464", "P16621", "FBgn0000464", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435" ] }, "reaction_10446403": { "compartment": "compartment_70101", "id": "reaction_10446403", "reactome": "R-DME-388824", "name": "PTPRF, PTPRS, PTPRD bind Liprins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446392", "species_10446397" ], "products": [ "species_10446401" ], "modifiers": [], "additional_components": [ "Q9VU88", "FBgn0036376", "M9PCD4", "FBgn0046704", "FBgn0000464", "P16621", "FBgn0000464", "Q9VU88", "FBgn0036376", "M9PCD4", "FBgn0046704" ] }, "reaction_10481248": { "compartment": "compartment_876", "id": "reaction_10481248", "reactome": "R-DME-6797554", "name": "ABP1 binds SHANK proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442084", "species_10481244" ], "products": [ "species_10481246" ], "modifiers": [], "additional_components": [ "FBgn0036372", "A1Z9K8", "FBgn0040752", "Q7KT70", "FBgn0001987", "Q9W1B3", "FBgn0034972", "Q9VIC7", "FBgn0051146", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "Q7K1T1", "FBgn0259978", "A1Z9K8", "FBgn0040752", "Q7KT70", "FBgn0001987", "Q9W1B3", "FBgn0034972", "Q9VIC7", "FBgn0051146", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "Q7K1T1", "FBgn0259978", "Q9VU84", "FBgn0036372" ] }, "reaction_10481136": { "compartment": "compartment_70101", "id": "reaction_10481136", "reactome": "R-DME-6797553", "name": "Protein 4.1 binds CASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445828", "species_10481132" ], "products": [ "species_10481134" ], "modifiers": [], "additional_components": [ "FBgn0013759", "Q9VFU8", "FBgn0004049", "Q9V8R9", "FBgn0010434", "Q9VFU8", "FBgn0004049", "Q9V8R9", "FBgn0010434", "Q24210", "FBgn0013759" ] }, "reaction_10488289": { "compartment": "compartment_876", "id": "reaction_10488289", "reactome": "R-DME-8849906", "name": "SALM1 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488267", "species_10488250" ], "products": [ "species_10488287" ], "modifiers": [], "additional_components": [ "FBgn0031016", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "Q9VWI6", "FBgn0031016" ] }, "reaction_10488305": { "compartment": "compartment_876", "id": "reaction_10488305", "reactome": "R-DME-8849908", "name": "SALM4 binds flotillin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488301", "species_10488265" ], "products": [ "species_10488303" ], "modifiers": [], "additional_components": [ "O61492", "FBgn0264078", "FBgn0031016", "Q9VWI6", "FBgn0031016", "O61492", "FBgn0264078" ] }, "reaction_10488275": { "compartment": "compartment_876", "id": "reaction_10488275", "reactome": "R-DME-8849882", "name": "SALMs 1-4 bind reticulon 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488271", "species_10488265" ], "products": [ "species_10488273" ], "modifiers": [], "additional_components": [ "FBgn0053113", "FBgn0031016", "Q9VWI6", "FBgn0031016", "E1JHT6", "FBgn0053113" ] }, "reaction_10488263": { "compartment": "compartment_876", "id": "reaction_10488263", "reactome": "R-DME-8849881", "name": "SALM2 associate with AMPA and NMDA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488259", "species_10488257" ], "products": [ "species_10488261" ], "modifiers": [], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "FBgn0031016", "Q9VWI6", "FBgn0031016", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382" ] }, "reaction_10488281": { "compartment": "compartment_876", "id": "reaction_10488281", "reactome": "R-DME-8849891", "name": "SALMs 1-3 bind to PSD-95 family members", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488277", "species_10488257" ], "products": [ "species_10488279" ], "modifiers": [], "additional_components": [ "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "FBgn0031016", "Q9VWI6", "FBgn0031016", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624" ] }, "reaction_10488252": { "compartment": "compartment_876", "id": "reaction_10488252", "reactome": "R-DME-8849878", "name": "PSD-95 binds NMDA receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488248", "species_10449288" ], "products": [ "species_10488250" ], "modifiers": [], "additional_components": [ "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "species_29424", "species_210382" ] }, "reaction_10489100": { "compartment": "compartment_876", "id": "reaction_10489100", "reactome": "R-DME-8855648", "name": "SALM3 binds LAR-RPTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488269", "species_10446397" ], "products": [ "species_10489098" ], "modifiers": [], "additional_components": [ "FBgn0031016", "FBgn0000464", "P16621", "FBgn0000464", "Q9VWI6", "FBgn0031016" ] }, "reaction_10488285": { "compartment": "compartment_876", "id": "reaction_10488285", "reactome": "R-DME-8849900", "name": "SALMs1-3 bind each other in cis interactions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488257" ], "products": [ "species_10488283" ], "modifiers": [], "additional_components": [ "FBgn0031016", "Q9VWI6", "FBgn0031016" ] }, "reaction_10453051": { "compartment": "compartment_984", "id": "reaction_10453051", "reactome": "R-DME-500717", "name": "Activation of GRIK3 homomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446852", "species_10453044" ], "products": [ "species_10453048" ], "modifiers": [ [ "species_10453044", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382", "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382" ] }, "reaction_10453046": { "compartment": "compartment_984", "id": "reaction_10453046", "reactome": "R-DME-500708", "name": "GRIK3 homomer binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10451326" ], "products": [ "species_10453044" ], "modifiers": [], "additional_components": [ "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "Q9W365", "FBgn0052704", "Q9VW78", "FBgn0036937", "Q9VPV3", "FBgn0046113", "Q9VPI2", "FBgn0031209", "Q9VMP4", "FBgn0004620", "Q9VMP3", "FBgn0020429", "Q9VDH6", "FBgn0259215", "Q9VDH5", "FBgn0038837", "Q9V4A0", "FBgn0039927", "Q9TVI0", "FBgn0028422", "Q0KIF2", "FBgn0039916", "Q0KI42", "FBgn0051201", "Q0E8N6", "FBgn0026255", "E9NA96", "FBgn0031634", "species_352022", "species_210382" ] }, "reaction_10451534": { "compartment": "compartment_984", "id": "reaction_10451534", "reactome": "R-DME-451309", "name": "Edited Kainate Receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10451530" ], "products": [ "species_10451532" ], "modifiers": [], "additional_components": [ "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "species_352022", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "species_352022", "species_210382" ] }, "reaction_10451537": { "compartment": "compartment_984", "id": "reaction_10451537", "reactome": "R-DME-451310", "name": "Activation of Edited Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10451532", "catalyst" ] ], "additional_components": [ "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "species_352022", "species_210382" ] }, "reaction_10451406": { "compartment": "compartment_876", "id": "reaction_10451406", "reactome": "R-DME-451283", "name": "kainate receptor binds glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10451402" ], "products": [ "species_10451404" ], "modifiers": [], "additional_components": [ "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "species_352022", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "species_352022", "species_210382" ] }, "reaction_10451540": { "compartment": "compartment_70101", "id": "reaction_10451540", "reactome": "R-DME-451311", "name": "Activation of Ca-permeable Kainate receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10451404", "catalyst" ] ], "additional_components": [ "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9W450", "FBgn0029830", "P31007", "FBgn0001624", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VMP4", "FBgn0004620", "Q0KI42", "FBgn0051201", "Q9VMP3", "FBgn0020429", "Q0E8N6", "FBgn0026255", "Q9VDH6", "FBgn0259215", "Q9W365", "FBgn0052704", "E9NA96", "FBgn0031634", "Q9VDH5", "FBgn0038837", "Q9VW78", "FBgn0036937", "Q9V4A0", "FBgn0039927", "Q9VPV3", "FBgn0046113", "Q9TVI0", "FBgn0028422", "Q9VPI2", "FBgn0031209", "Q0KIF2", "FBgn0039916", "species_352022", "species_210382" ] }, "reaction_10442563": { "compartment": "compartment_70101", "id": "reaction_10442563", "reactome": "R-DME-205039", "name": "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442464", "species_29438" ], "products": [ "species_10442466", "species_29420" ], "modifiers": [ [ "species_10442560", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "A1ZAN6", "FBgn0023172", "A1ZBA1", "FBgn0050115", "Q9W0S2", "FBgn0264707", "Q8IQ97", "FBgn0003041", "A8DZ19", "FBgn0015803", "Q9VVC6", "FBgn0261547", "Q7K4E0", "FBgn0050440", "P26675", "Sos", "P91621", "FBgn0085447", "M9PBE1", "FBgn0032796", "M9ND00", "FBgn0023388", "X2JC00", "FBgn0025836", "P25157", "FBgn0000384", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VW85", "FBgn0261556" ] }, "reaction_10440306": { "compartment": "compartment_13231", "id": "reaction_10440306", "reactome": "R-DME-193666", "name": "Active JNK moves to the nucleus and phosphorylates different transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437429" ], "products": [ "species_10437365" ], "modifiers": [], "additional_components": [] }, "reaction_10442593": { "compartment": "compartment_70101", "id": "reaction_10442593", "reactome": "R-DME-205136", "name": "GTP-bound RAC contributes to JNK activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_29370", "species_10437429" ], "modifiers": [ [ "species_10442466", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10432761": { "compartment": "compartment_7660", "id": "reaction_10432761", "reactome": "R-DME-76056", "name": "Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432757", "species_10432697" ], "products": [ "species_10432759" ], "modifiers": [], "additional_components": [ "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463" ] }, "reaction_10457699": { "compartment": "compartment_70101", "id": "reaction_10457699", "reactome": "R-DME-1013020", "name": "Activation of GIRK/Kir3 Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10457696", "catalyst" ] ], "additional_components": [ "B7YZX2", "FBgn0032706", "species_352011", "Q9V3Q9", "FBgn0260446", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_216283": { "compartment": "compartment_7660", "id": "reaction_216283", "reactome": "R-DME-216283", "name": "RDX binds to and ubiquitinates CI", "reversible": "false", "notes": "HIB or Roadkill (RDX) is transcriptionally induced by Hedgehog signalling and binds directly to Cubitus Interruptus (CI), likely in competition with Supressor of Fused (SU(FU)), to link CI with a Cul3 aka guftagu (GFT)-based E3 ubiquitin ligase complex, leading to degradation of active nuclear CI.", "reactants": [ "species_216110", "species_216104", "species_205911" ], "products": [ "species_216204" ], "modifiers": [ [ "species_216104", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VFP2", "rdx", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "Q9VFP2", "rdx", "P19538", "ci", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VFP2", "rdx", "Q9V475", "GFT", "Q9NHX0", "ROC1B" ] }, "reaction_216282": { "compartment": "compartment_7660", "id": "reaction_216282", "reactome": "R-DME-216282", "name": "Ubiquitinated CI is degraded by the proteasome complex", "reversible": "false", "notes": "The ubiquitinated Cubitus Interruptus (CI) is marked for degradation in the nucleus by the 26S proteasome complex.", "reactants": [ "species_216204" ], "products": [ "species_216110", "species_216104" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "Q9VFP2", "rdx", "P19538", "ci", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VFP2", "rdx", "Q9V475", "GFT", "Q9NHX0", "ROC1B", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_10497363": { "compartment": "compartment_17963", "id": "reaction_10497363", "reactome": "R-DME-9603989", "name": "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9604808", "species_735682" ], "products": [ "species_205687", "species_9036984" ], "modifiers": [ [ "species_10497360", "catalyst" ] ], "additional_components": [ "Q24157", "FBgn0000221", "A1Z8R4", "FBgn0050036", "A1Z8R5", "FBgn0050037", "A1Z8R6", "FBgn0053145", "Q95RP8", "FBgn0040373", "Q9VLS8", "FBgn0031988", "Q9VZA6", "FBgn0035558", "Q9VLT0", "FBgn0031986" ] }, "reaction_10439963": { "compartment": "compartment_70101", "id": "reaction_10439963", "reactome": "R-DME-191352", "name": "HMGCR dimer reduces bHMG-CoA to MVA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374", "species_70106", "species_29364" ], "products": [ "species_29366", "species_76194", "species_191424" ], "modifiers": [ [ "species_10439960", "catalyst" ] ], "additional_components": [ "P14773", "FBgn0263782" ] }, "reaction_10439993": { "compartment": "compartment_70101", "id": "reaction_10439993", "reactome": "R-DME-191414", "name": "MVD decarboxylates MVA5PP to IPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191403" ], "products": [ "species_29372", "species_29370", "species_113528", "species_191362" ], "modifiers": [ [ "species_10439990", "catalyst" ] ], "additional_components": [ "Q9VXQ3", "FBgn0030683" ] }, "reaction_10440468": { "compartment": "compartment_70101", "id": "reaction_10440468", "reactome": "R-DME-194698", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_194644", "species_29364" ], "products": [ "species_194633", "species_29366" ], "modifiers": [ [ "species_10440465", "catalyst" ] ], "additional_components": [ "FBgn0034657" ] }, "reaction_10487854": { "compartment": "compartment_70101", "id": "reaction_10487854", "reactome": "R-DME-8848215", "name": "ACAT2 condenses 2 Ac-CoA to form ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_191293", "species_29356", "species_76194" ], "modifiers": [ [ "species_10487851", "catalyst" ] ], "additional_components": [ "Q9W0H6", "FBgn0035203" ] }, "reaction_10439953": { "compartment": "compartment_70101", "id": "reaction_10439953", "reactome": "R-DME-191323", "name": "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191293", "species_76183" ], "products": [ "species_29356", "species_191374", "species_76194" ], "modifiers": [ [ "species_10439950", "catalyst" ] ], "additional_components": [ "FBgn0010611" ] }, "reaction_10439983": { "compartment": "compartment_70101", "id": "reaction_10439983", "reactome": "R-DME-191382", "name": "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362" ], "products": [ "species_191324" ], "modifiers": [ [ "species_10439980", "catalyst" ] ], "additional_components": [ "Q9VDC2", "FBgn0038876", "species_29926" ] }, "reaction_10440463": { "compartment": "compartment_13231", "id": "reaction_10440463", "reactome": "R-DME-194674", "name": "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194681", "species_194725", "species_194688" ], "products": [ "species_194668", "species_194704" ], "modifiers": [ [ "species_10440460", "catalyst" ] ], "additional_components": [ "FBgn0034657" ] }, "reaction_10439948": { "compartment": "compartment_70101", "id": "reaction_10439948", "reactome": "R-DME-191322", "name": "Addition of isopentenyl pyrophosphate to DMAPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191324", "species_191362" ], "products": [ "species_111294", "species_191409" ], "modifiers": [ [ "species_10439942", "catalyst" ] ], "additional_components": [ "species_29926", "Q7KN61", "FBgn0025373", "Q9VS54", "FBgn0019662" ] }, "reaction_10439945": { "compartment": "compartment_70101", "id": "reaction_10439945", "reactome": "R-DME-191303", "name": "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191409", "species_191362" ], "products": [ "species_111294", "species_191385" ], "modifiers": [ [ "species_10439942", "catalyst" ] ], "additional_components": [ "species_29926", "Q7KN61", "FBgn0025373", "Q9VS54", "FBgn0019662" ] }, "reaction_10471177": { "compartment": "compartment_17957", "id": "reaction_10471177", "reactome": "R-DME-5250531", "name": "ARV1 transports CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384" ], "products": [ "species_171095" ], "modifiers": [ [ "species_10471174", "catalyst" ] ], "additional_components": [ "FBgn0052442" ] }, "reaction_10493848": { "compartment": "compartment_70101", "id": "reaction_10493848", "reactome": "R-DME-8952137", "name": "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_191265" ], "products": [ "species_8952135", "species_29372" ], "modifiers": [ [ "species_10493845", "catalyst" ] ], "additional_components": [ "FBgn0051717" ] }, "reaction_10439973": { "compartment": "compartment_70101", "id": "reaction_10439973", "reactome": "R-DME-191380", "name": "Mevalonate is phosphorylated to mevalonate-5-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191424" ], "products": [ "species_29370", "species_191296" ], "modifiers": [ [ "species_10439970", "catalyst" ] ], "additional_components": [ "Q7K2V9", "FBgn0061359" ] }, "reaction_10440001": { "compartment": "compartment_70101", "id": "reaction_10440001", "reactome": "R-DME-191422", "name": "Mevalonate-5-phosphate is further phosphorylated.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_191296" ], "products": [ "species_29370", "species_191403" ], "modifiers": [ [ "species_10439998", "catalyst" ] ], "additional_components": [ "FBgn0032811" ] }, "reaction_10429104": { "compartment": "compartment_70101", "id": "reaction_10429104", "reactome": "R-DME-71732", "name": "pyrophosphate + H2O => 2 orthophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111294", "species_29356" ], "products": [ "species_29372" ], "modifiers": [ [ "species_10429101", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "O77460", "FBgn0016687" ] }, "reaction_10458157": { "compartment": "compartment_7660", "id": "reaction_10458157", "reactome": "R-DME-1234172", "name": "Nuclear VBC complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458144", "species_10458150" ], "products": [ "species_10437973", "species_10458154" ], "modifiers": [ [ "species_10458144", "catalyst" ] ], "additional_components": [ "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24167", "FBgn0266411", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411" ] }, "reaction_10458075": { "compartment": "compartment_70101", "id": "reaction_10458075", "reactome": "R-DME-1234159", "name": "Proteasome proteolyzes ub-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458071" ], "products": [ "species_10458073", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10458168": { "compartment": "compartment_70101", "id": "reaction_10458168", "reactome": "R-DME-1234183", "name": "Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458032", "species_10458067" ], "products": [ "species_10458093" ], "modifiers": [], "additional_components": [ "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q24167", "FBgn0266411" ] }, "reaction_10458166": { "compartment": "compartment_7660", "id": "reaction_10458166", "reactome": "R-DME-1234181", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458085", "species_113671", "species_113685" ], "products": [ "species_10458134", "species_159942", "species_159939" ], "modifiers": [ [ "species_10458114", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "species_111793", "Q8SX21", "FBgn0264785", "species_351595" ] }, "reaction_10458117": { "compartment": "compartment_7660", "id": "reaction_10458117", "reactome": "R-DME-1234165", "name": "Nuclear PHD1,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458087", "species_113671", "species_113685" ], "products": [ "species_10458104", "species_159942", "species_159939" ], "modifiers": [ [ "species_10458114", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "species_111793", "Q8SX21", "FBgn0264785", "species_351595" ] }, "reaction_10458164": { "compartment": "compartment_70101", "id": "reaction_10458164", "reactome": "R-DME-1234177", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29368", "species_10458079" ], "products": [ "species_10458036", "species_29434", "species_113528" ], "modifiers": [ [ "species_10458067", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530" ] }, "reaction_10458146": { "compartment": "compartment_7660", "id": "reaction_10458146", "reactome": "R-DME-1234169", "name": "Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458132", "species_10458142" ], "products": [ "species_10458144" ], "modifiers": [], "additional_components": [ "FBgn0266411", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411" ] }, "reaction_10458162": { "compartment": "compartment_70101", "id": "reaction_10458162", "reactome": "R-DME-1234175", "name": "ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458154" ], "products": [ "species_10458043" ], "modifiers": [], "additional_components": [ "Q9V9R2", "FBgn0032956", "Q7JWD6", "FBgn0266711", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q9W5E1", "Roc1a", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24167", "FBgn0266411", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956" ] }, "reaction_10458160": { "compartment": "compartment_70101", "id": "reaction_10458160", "reactome": "R-DME-1234173", "name": "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_10458081", "species_29368" ], "products": [ "species_29434", "species_113528", "species_10458039" ], "modifiers": [ [ "species_10458067", "catalyst" ] ], "additional_components": [ "FBgn0266411", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530" ] }, "reaction_10458096": { "compartment": "compartment_70101", "id": "reaction_10458096", "reactome": "R-DME-1234163", "name": "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458091", "species_10458093" ], "products": [ "species_10458069", "species_10427563" ], "modifiers": [ [ "species_10458093", "catalyst" ] ], "additional_components": [ "Q9Y165", "FBgn0027609", "P25867", "eff", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q24167", "FBgn0266411", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9W5E1", "Roc1a", "Q9V9R2", "FBgn0032956", "Q8SX21", "FBgn0264785", "species_351595", "species_111793", "Q9VY77", "FBgn0030530", "Q24167", "FBgn0266411" ] }, "reaction_10479102": { "compartment": "compartment_5460", "id": "reaction_10479102", "reactome": "R-DME-5696197", "name": "NUDT2 hydrolyses GP4G to GTP, GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696199", "species_113521" ], "products": [ "species_5696194", "species_113573" ], "modifiers": [ [ "species_10479099", "catalyst" ] ], "additional_components": [ "FBgn0051713" ] }, "reaction_10468283": { "compartment": "compartment_984", "id": "reaction_10468283", "reactome": "R-DME-3299682", "name": "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_3299686" ], "products": [ "species_351629", "species_352327" ], "modifiers": [ [ "species_10468280", "catalyst" ] ], "additional_components": [ "species_1562550", "species_209799", "P61851", "FBgn0003462" ] }, "reaction_10468411": { "compartment": "compartment_70101", "id": "reaction_10468411", "reactome": "R-DME-3341343", "name": "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_29408" ], "products": [ "species_10430994", "species_29356" ], "modifiers": [ [ "species_10468408", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "Q9V3P0", "FBgn0040309", "Q960M4", "FBgn0038570", "Q9VUM4", "FBgn0036490" ] }, "reaction_10468378": { "compartment": "compartment_70616", "id": "reaction_10468378", "reactome": "R-DME-3341294", "name": "Superoxide reduces cytochrome c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_10436150" ], "products": [ "species_10436148", "species_189461" ], "modifiers": [], "additional_components": [ "CHEBI:38574", "P84029", "FBgn0284248", "CHEBI:38573", "P84029", "FBgn0284248" ] }, "reaction_10470231": { "compartment": "compartment_17963", "id": "reaction_10470231", "reactome": "R-DME-4837364", "name": "Secretion of SOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470229" ], "products": [ "species_10468280" ], "modifiers": [], "additional_components": [ "species_1562550", "species_209799", "P61851", "FBgn0003462", "species_1562550", "species_209799", "P61851", "FBgn0003462" ] }, "reaction_10468372": { "compartment": "compartment_5460", "id": "reaction_10468372", "reactome": "R-DME-3322995", "name": "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468350", "species_1614617" ], "products": [ "species_10468353", "species_113521" ], "modifiers": [ [ "species_10468369", "catalyst" ] ], "additional_components": [ "FBgn0035334", "FBgn0035334", "Q960M4", "FBgn0038570", "Q9VEJ0", "FBgn0038519" ] }, "reaction_10486317": { "compartment": "compartment_12045", "id": "reaction_10486317", "reactome": "R-DME-6807557", "name": "NOX4, NOX5 reduce O2 to O2.-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_70106", "species_1222424", "species_29366" ], "modifiers": [ [ "species_10486314", "catalyst" ] ], "additional_components": [ "FBgn0085428" ] }, "reaction_10468272": { "compartment": "compartment_5460", "id": "reaction_10468272", "reactome": "R-DME-3299680", "name": "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_3299683" ], "products": [ "species_113533", "species_1614617" ], "modifiers": [ [ "species_10468269", "catalyst" ] ], "additional_components": [ "Q00637", "FBgn0010213", "species_266099" ] }, "reaction_10432650": { "compartment": "compartment_17951", "id": "reaction_10432650", "reactome": "R-DME-76031", "name": "2 H2O2 => O2 + 2 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113575" ], "products": [ "species_113535", "species_141343" ], "modifiers": [ [ "species_10432647", "catalyst" ] ], "additional_components": [ "species_71185", "species_29364", "P17336", "FBgn0000261" ] }, "reaction_10468778": { "compartment": "compartment_5460", "id": "reaction_10468778", "reactome": "R-DME-3697894", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468350", "species_3697881" ], "products": [ "species_10468353", "species_3697842", "species_113521" ], "modifiers": [ [ "species_10468367", "catalyst" ] ], "additional_components": [ "FBgn0035334", "FBgn0035334", "FBgn0038570" ] }, "reaction_10468775": { "compartment": "compartment_70101", "id": "reaction_10468775", "reactome": "R-DME-3697882", "name": "PRDX5 reduces peroxynitrite to nitrite using TXN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_1222481" ], "products": [ "species_10430994", "species_29356", "species_1222379" ], "modifiers": [ [ "species_10468406", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "FBgn0038570" ] }, "reaction_10468293": { "compartment": "compartment_70101", "id": "reaction_10468293", "reactome": "R-DME-3299691", "name": "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1222424" ], "products": [ "species_29368", "species_29408" ], "modifiers": [ [ "species_10468290", "catalyst" ] ], "additional_components": [ "P61851", "FBgn0003462", "species_1562550", "species_209799" ] }, "reaction_10431013": { "compartment": "compartment_70101", "id": "reaction_10431013", "reactome": "R-DME-73646", "name": "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430994", "species_70106", "species_29364" ], "products": [ "species_10430996", "species_29366" ], "modifiers": [ [ "species_10431010", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "species_113596", "Q9VNT5", "FBgn0037170", "P91938", "FBgn0020653" ] }, "reaction_10468833": { "compartment": "compartment_17927", "id": "reaction_10468833", "reactome": "R-DME-3777112", "name": "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3341308", "species_163953" ], "products": [ "species_189481", "species_189461" ], "modifiers": [ [ "species_10468830", "catalyst" ] ], "additional_components": [ "species_209799", "species_1562550", "P61851", "FBgn0003462" ] }, "reaction_10461593": { "compartment": "compartment_70101", "id": "reaction_10461593", "reactome": "R-DME-1855177", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10461590", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "species_74016", "P13217", "FBgn0262738" ] }, "reaction_10461704": { "compartment": "compartment_70101", "id": "reaction_10461704", "reactome": "R-DME-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10461569", "catalyst" ] ], "additional_components": [ "M9PHS8", "FBgn0030761", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10461652": { "compartment": "compartment_70101", "id": "reaction_10461652", "reactome": "R-DME-1855205", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_114520" ], "modifiers": [ [ "species_10461649", "catalyst" ] ], "additional_components": [ "Q7KMQ6", "Pten", "species_29926" ] }, "reaction_10461698": { "compartment": "compartment_12045", "id": "reaction_10461698", "reactome": "R-DME-1855214", "name": "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023856", "species_29356" ], "products": [ "species_114520", "species_1500596" ], "modifiers": [ [ "species_10461695", "catalyst" ] ], "additional_components": [ "Q9VIF2", "FBgn0032923", "Q9VIE9", "FBgn0263050", "species_74016" ] }, "reaction_10461713": { "compartment": "compartment_876", "id": "reaction_10461713", "reactome": "R-DME-1855221", "name": "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10461710", "catalyst" ] ], "additional_components": [ "species_74016", "Q9VXH3", "FBgn0003416" ] }, "reaction_10461681": { "compartment": "compartment_876", "id": "reaction_10461681", "reactome": "R-DME-1855213", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994170" ], "products": [ "species_29372", "species_994123" ], "modifiers": [ [ "species_10461676", "catalyst" ] ], "additional_components": [ "FBgn0023508" ] }, "reaction_10461472": { "compartment": "compartment_70101", "id": "reaction_10461472", "reactome": "R-DME-1855153", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114520" ], "products": [ "species_29370", "species_994170" ], "modifiers": [ [ "species_10461469", "catalyst" ] ], "additional_components": [ "species_74016", "Q7KV26", "FBgn0283680", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VL83", "FBgn0032147" ] }, "reaction_10465533": { "compartment": "compartment_70101", "id": "reaction_10465533", "reactome": "R-DME-2317332", "name": "PIP3 recruits AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10446639" ], "products": [ "species_10440860" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10484665": { "compartment": "compartment_70101", "id": "reaction_10484665", "reactome": "R-DME-6799604", "name": "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_449701" ], "products": [ "species_29512", "species_31633" ], "modifiers": [ [ "species_10484662", "catalyst" ] ], "additional_components": [ "Q9VMP9", "FBgn0031717" ] }, "reaction_10481369": { "compartment": "compartment_70101", "id": "reaction_10481369", "reactome": "R-DME-6798335", "name": "BPGM dimer isomerises 1,3BPG to 2,3BPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29800" ], "products": [ "species_6798337" ], "modifiers": [ [ "species_10481366", "catalyst" ] ], "additional_components": [ "Q9VAN7", "FBgn0014869", "Q8T8W6", "FBgn0038957", "Q9VGB6", "FBgn0011270" ] }, "reaction_10429145": { "compartment": "compartment_70101", "id": "reaction_10429145", "reactome": "R-DME-71802", "name": "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_29370", "species_30533" ], "modifiers": [ [ "species_10429142", "catalyst" ], [ "species_30533", "catalyst" ] ], "additional_components": [ "Q9VWH7", "FBgn0027621" ] }, "reaction_10427841": { "compartment": "compartment_70101", "id": "reaction_10427841", "reactome": "R-DME-70262", "name": "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30533" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10427838", "catalyst" ] ], "additional_components": [ "Q9VWH7", "FBgn0027621" ] }, "reaction_10428045": { "compartment": "compartment_70101", "id": "reaction_10428045", "reactome": "R-DME-70471", "name": "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537" ], "products": [ "species_29512" ], "modifiers": [ [ "species_10428042", "catalyst" ] ], "additional_components": [ "P52029", "FBgn0003074" ] }, "reaction_10428013": { "compartment": "compartment_70101", "id": "reaction_10428013", "reactome": "R-DME-70454", "name": "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75970" ], "products": [ "species_29578" ], "modifiers": [ [ "species_10428010", "catalyst" ] ], "additional_components": [ "P29613", "FBgn0086355" ] }, "reaction_10429003": { "compartment": "compartment_70101", "id": "reaction_10429003", "reactome": "R-DME-71660", "name": "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30485" ], "products": [ "species_29356", "species_29492" ], "modifiers": [ [ "species_10428103", "catalyst" ] ], "additional_components": [ "species_29926", "P15007", "FBgn0000579" ] }, "reaction_10429001": { "compartment": "compartment_70101", "id": "reaction_10429001", "reactome": "R-DME-71654", "name": "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29728" ], "products": [ "species_30485" ], "modifiers": [ [ "species_10428883", "catalyst" ] ], "additional_components": [ "Q9VAN7", "FBgn0014869" ] }, "reaction_10428902": { "compartment": "compartment_70101", "id": "reaction_10428902", "reactome": "R-DME-71496", "name": "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014" ], "products": [ "species_29578", "species_75970" ], "modifiers": [ [ "species_10428897", "catalyst" ] ], "additional_components": [ "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064" ] }, "reaction_10427973": { "compartment": "compartment_70101", "id": "reaction_10427973", "reactome": "R-DME-70420", "name": "HK1,2,3,GCK phosphorylate Glc to form G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_70113" ], "products": [ "species_70106", "species_29370", "species_30537" ], "modifiers": [ [ "species_10427970", "catalyst" ] ], "additional_components": [ "Q7JYW9", "FBgn0001187", "Q9W330", "FBgn0001186", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710" ] }, "reaction_10429157": { "compartment": "compartment_70101", "id": "reaction_10429157", "reactome": "R-DME-71850", "name": "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_29800" ], "products": [ "species_113592", "species_29728" ], "modifiers": [ [ "species_10428087", "catalyst" ] ], "additional_components": [ "species_29926", "Q01604", "FBgn0250906" ] }, "reaction_10495131": { "compartment": "compartment_70101", "id": "reaction_10495131", "reactome": "R-DME-8955760", "name": "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29800" ], "products": [ "species_70106", "species_8955759", "species_29728" ], "modifiers": [ [ "species_10427859", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z9V3", "FBgn0033969", "A1Z7P1", "FBgn0033377" ] }, "reaction_10428035": { "compartment": "compartment_70101", "id": "reaction_10428035", "reactome": "R-DME-70467", "name": "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29512" ], "products": [ "species_30014", "species_29370" ], "modifiers": [ [ "species_10428032", "catalyst" ], [ "species_29370", "catalyst" ], [ "species_30533", "catalyst" ], [ "species_76577", "catalyst" ], [ "species_76190", "inhibitor" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "P52034", "FBgn0003071" ] }, "reaction_10428003": { "compartment": "compartment_70101", "id": "reaction_10428003", "reactome": "R-DME-70449", "name": "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_29578", "species_29360" ], "products": [ "species_70106", "species_29800", "species_73473" ], "modifiers": [ [ "species_10428000", "catalyst" ] ], "additional_components": [ "P07486", "FBgn0001091", "Q7JY07", "FBgn0034173", "P07487", "FBgn0001092" ] }, "reaction_10429058": { "compartment": "compartment_70101", "id": "reaction_10429058", "reactome": "R-DME-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29370", "species_29492" ], "products": [ "species_113592", "species_29398" ], "modifiers": [ [ "species_10429055", "catalyst" ], [ "species_30014", "catalyst" ], [ "species_76183", "inhibitor" ], [ "species_29358", "inhibitor" ], [ "species_30389", "inhibitor" ] ], "additional_components": [ "Q9VNZ9", "FBgn0037115", "Q9VFG4", "FBgn0038258", "Q9VVH0", "FBgn0036723", "Q9VD23", "FBgn0038952", "Q9VQH0", "FBgn0031462", "O62619", "FBgn0267385", "species_29926", "species_74126" ] }, "reaction_10437795": { "compartment": "compartment_13231", "id": "reaction_10437795", "reactome": "R-DME-170825", "name": "glucokinase [nucleoplasm] => glucokinase [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437793" ], "products": [ "species_10427948" ], "modifiers": [], "additional_components": [ "Q9W330", "FBgn0001186", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710", "Q7JYW9", "FBgn0001187", "Q7JYW9", "FBgn0001187", "Q9W330", "FBgn0001186", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710" ] }, "reaction_10453164": { "compartment": "compartment_70101", "id": "reaction_10453164", "reactome": "R-DME-532549", "name": "MPI isomerises Fru6P to Man6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512" ], "products": [ "species_532562" ], "modifiers": [ [ "species_10453161", "catalyst" ] ], "additional_components": [ "FBgn0286506" ] }, "reaction_10450486": { "compartment": "compartment_70101", "id": "reaction_10450486", "reactome": "R-DME-446201", "name": "PMM1,2 isomerise Man6P to Man1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_532562" ], "products": [ "species_532531" ], "modifiers": [ [ "species_10450481", "catalyst" ] ], "additional_components": [ "FBgn0036300" ] }, "reaction_10447638": { "compartment": "compartment_876", "id": "reaction_10447638", "reactome": "R-DME-419002", "name": "Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447632", "species_10442033", "species_10447634", "species_10447624" ], "products": [ "species_10447636" ], "modifiers": [], "additional_components": [ "P18824", "arm", "FBgn0262018", "FBgn0260799", "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q8SYP8", "FBgn0033348", "P35220", "FBgn0010215", "P07666", "FBgn0003510", "Q7PLI0", "FBgn0260799", "Q9VJB6", "FBgn0262018", "P18824", "arm" ] }, "reaction_10447616": { "compartment": "compartment_204883", "id": "reaction_10447616", "reactome": "R-DME-419001", "name": "Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442033", "species_140648" ], "products": [ "species_10447614" ], "modifiers": [], "additional_components": [ "FBgn0262018", "Q9VJB6", "FBgn0262018" ] }, "reaction_10449511": { "compartment": "compartment_70101", "id": "reaction_10449511", "reactome": "R-DME-432909", "name": "Interaction of Plectin with Integrin beta 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443378", "species_10441643" ], "products": [ "species_10449509" ], "modifiers": [], "additional_components": [ "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "FBgn0013733", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657" ] }, "reaction_10449527": { "compartment": "compartment_984", "id": "reaction_10449527", "reactome": "R-DME-432956", "name": "BP230 is recruited to the hemidesmosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449523", "species_10449519" ], "products": [ "species_10449525" ], "modifiers": [], "additional_components": [ "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10450422": { "compartment": "compartment_984", "id": "reaction_10450422", "reactome": "R-DME-446089", "name": "BP180 interacts extracellularly with Laminin 332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443411", "species_10450420" ], "products": [ "species_10449519" ], "modifiers": [], "additional_components": [ "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10450418": { "compartment": "compartment_70101", "id": "reaction_10450418", "reactome": "R-DME-446083", "name": "CD151 interacts with BP180 and the integrin alpha 6 subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449525", "species_10450414" ], "products": [ "species_10450416" ], "modifiers": [], "additional_components": [ "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "FBgn0043550", "Q8IQK9", "FBgn0043550", "A1Z9J3", "FBgn0013733", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10449180": { "compartment": "compartment_70101", "id": "reaction_10449180", "reactome": "R-DME-430341", "name": "Mig-2 recruits Migfilin to the cell-ECM adhesions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449176", "species_10449164" ], "products": [ "species_10449178" ], "modifiers": [], "additional_components": [ "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688", "FBgn0011642", "Q9N675", "FBgn0011642", "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688" ] }, "reaction_10450586": { "compartment": "compartment_70101", "id": "reaction_10450586", "reactome": "R-DME-446391", "name": "Formation of the PINCH-ILK-parvin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450580", "species_10450582", "species_10449503" ], "products": [ "species_10450584" ], "modifiers": [], "additional_components": [ "FBgn0028427", "Q9V400", "FBgn0028427", "Q8INQ9", "FBgn0020249" ] }, "reaction_10449507": { "compartment": "compartment_70101", "id": "reaction_10449507", "reactome": "R-DME-432897", "name": "ILK interacts with beta-1 integrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441029", "species_10449503" ], "products": [ "species_10449505" ], "modifiers": [], "additional_components": [ "FBgn0004657", "FBgn0028427", "Q9V400", "FBgn0028427", "P11584", "FBgn0004657" ] }, "reaction_10450563": { "compartment": "compartment_70101", "id": "reaction_10450563", "reactome": "R-DME-446322", "name": "PARVA associates with Paxillin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450559", "species_10438879" ], "products": [ "species_10450561" ], "modifiers": [], "additional_components": [ "FBgn0052528", "FBgn0041789", "Q9VWD0", "FBgn0052528", "Q2PDT4", "FBgn0041789" ] }, "reaction_10450567": { "compartment": "compartment_70101", "id": "reaction_10450567", "reactome": "R-DME-446364", "name": "Migfilin interacts with VASP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448617", "species_10449164" ], "products": [ "species_10450565" ], "modifiers": [], "additional_components": [ "FBgn0011642", "Q9N675", "FBgn0011642", "Q8T4F7", "ena" ] }, "reaction_10449188": { "compartment": "compartment_70101", "id": "reaction_10449188", "reactome": "R-DME-430347", "name": "MigFilin associates with Filamin and F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449184", "species_10449131", "species_10449164" ], "products": [ "species_10449186" ], "modifiers": [], "additional_components": [ "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "FBgn0014141", "FBgn0011642", "Q9N675", "FBgn0011642", "Q9VEN1", "FBgn0014141", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592" ] }, "reaction_10449515": { "compartment": "compartment_70101", "id": "reaction_10449515", "reactome": "R-DME-432946", "name": "PARVB/Affixin interacts with alpha PIX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449141", "species_10442520" ], "products": [ "species_10449513" ], "modifiers": [], "additional_components": [ "FBgn0052528", "FBgn0015803", "A8DZ19", "FBgn0015803", "Q9VWD0", "FBgn0052528" ] }, "reaction_10449145": { "compartment": "compartment_70101", "id": "reaction_10449145", "reactome": "R-DME-430308", "name": "PARVB interacts with Alpha-actinin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449136", "species_10449141" ], "products": [ "species_10449143" ], "modifiers": [], "additional_components": [ "FBgn0000667", "FBgn0052528", "Q9VWD0", "FBgn0052528", "P18091", "FBgn0000667" ] }, "reaction_10449159": { "compartment": "compartment_70101", "id": "reaction_10449159", "reactome": "R-DME-430311", "name": "Rsu-1 interacts with Pinch1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449155", "species_10449150" ], "products": [ "species_10449157" ], "modifiers": [], "additional_components": [ "FBgn0020249", "FBgn0028546", "Q9V428", "FBgn0028546", "Q8INQ9", "FBgn0020249" ] }, "reaction_10450576": { "compartment": "compartment_70101", "id": "reaction_10450576", "reactome": "R-DME-446372", "name": "Association of PARVA with TESK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450572", "species_10450559" ], "products": [ "species_10450574" ], "modifiers": [], "additional_components": [ "FBgn0004876", "FBgn0052528", "Q9VWD0", "FBgn0052528", "Q9VE06", "FBgn0004876" ] }, "reaction_10444555": { "compartment": "compartment_876", "id": "reaction_10444555", "reactome": "R-DME-373732", "name": "Nephrin trans-homophilic interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444454" ], "products": [ "species_10444456" ], "modifiers": [], "additional_components": [ "FBgn0024189", "Q0E9F2", "FBgn0024189" ] }, "reaction_10451625": { "compartment": "compartment_876", "id": "reaction_10451625", "reactome": "R-DME-451757", "name": "Heterodimerization of nephrin and KIRREL2, KIRREL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451621", "species_10444456" ], "products": [ "species_10451623" ], "modifiers": [], "additional_components": [ "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "A0A023GPK8", "FBgn0051774", "Q0E9F2", "FBgn0024189", "Q0E9F2", "FBgn0024189", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "A0A023GPK8", "FBgn0051774" ] }, "reaction_10495542": { "compartment": "compartment_876", "id": "reaction_10495542", "reactome": "R-DME-8981534", "name": "Nephrin dimer:KIRREL binds FYN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444480", "species_10444516" ], "products": [ "species_10444577" ], "modifiers": [], "additional_components": [ "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "FBgn0262733", "P00528", "FBgn0262733", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189" ] }, "reaction_10444566": { "compartment": "compartment_876", "id": "reaction_10444566", "reactome": "R-DME-373734", "name": "Nephrin interacts with Podocin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444528", "species_10444562" ], "products": [ "species_10444564" ], "modifiers": [], "additional_components": [ "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733", "Q9VZA4", "FBgn0260657", "Q9VZA4", "FBgn0260657", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733" ] }, "reaction_10444580": { "compartment": "compartment_876", "id": "reaction_10444580", "reactome": "R-DME-373747", "name": "Phosphorylation of nephrin by FYN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444577", "species_113592" ], "products": [ "species_10444528", "species_29370" ], "modifiers": [ [ "species_10444577", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189" ] }, "reaction_10444532": { "compartment": "compartment_876", "id": "reaction_10444532", "reactome": "R-DME-373724", "name": "Nephrin binds NCK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444528", "species_10444486" ], "products": [ "species_10444530" ], "modifiers": [], "additional_components": [ "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733", "Q9VPU1", "dock", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189", "P00528", "FBgn0262733" ] }, "reaction_10444482": { "compartment": "compartment_876", "id": "reaction_10444482", "reactome": "R-DME-373714", "name": "Cis-Heterodimerization of nephrin and KIRREL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444456", "species_10444478" ], "products": [ "species_10444480" ], "modifiers": [], "additional_components": [ "Q0E9F2", "FBgn0024189", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "A0A023GPK8", "FBgn0051774", "Q9W4T9", "FBgn0028369", "Q9VQW7", "FBgn0000547", "Q08180", "FBgn0003285", "Q0E9F2", "FBgn0024189" ] }, "reaction_10484751": { "compartment": "compartment_70101", "id": "reaction_10484751", "reactome": "R-DME-6800138", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484729", "species_71284" ], "products": [ "species_10484736", "species_71285" ], "modifiers": [ [ "species_10484748", "catalyst" ] ], "additional_components": [ "Q9VPH7", "FBgn0036974", "Q9VK85", "FBgn0020443", "species_29438", "Q9VPH7", "FBgn0036974", "Q9VK85", "FBgn0020443", "species_29438", "Q9VP65", "FBgn0037061", "Q9VQF8", "FBgn0031454" ] }, "reaction_10469966": { "compartment": "compartment_70101", "id": "reaction_10469966", "reactome": "R-DME-4608854", "name": "SMURF1/2 are recruited to the DVL2:PARD6A complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469940", "species_10437960" ], "products": [ "species_10469961" ], "modifiers": [], "additional_components": [ "O97111", "FBgn0026192", "P51140", "phospho-dsh", "FBgn0029006", "Q9V853", "FBgn0029006", "O97111", "FBgn0026192", "P51140", "phospho-dsh" ] }, "reaction_10469964": { "compartment": "compartment_70101", "id": "reaction_10469964", "reactome": "R-DME-4608852", "name": "SMURF1/2 ubiquitinates PRICKLE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10469951" ], "products": [ "species_10469959" ], "modifiers": [ [ "species_10469961", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9U1I1", "FBgn0263934", "A1Z6W3", "PK", "Q9U1I1", "FBgn0263934", "A1Z6W3", "PK", "Q9V853", "FBgn0029006", "O97111", "FBgn0026192", "P51140", "phospho-dsh" ] }, "reaction_10470337": { "compartment": "compartment_876", "id": "reaction_10470337", "reactome": "R-DME-5099886", "name": "WNT5A binding to FZD promotes PRICKLE1 degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470333", "species_10468078" ], "products": [ "species_10470335" ], "modifiers": [], "additional_components": [ "Q9VVX3", "FZ2", "FBgn0010194", "P28466", "FBgn0010194", "Q9VVX3", "FZ2" ] }, "reaction_10469968": { "compartment": "compartment_70101", "id": "reaction_10469968", "reactome": "R-DME-4608855", "name": "PRICKLE1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469959" ], "products": [], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9U1I1", "FBgn0263934", "A1Z6W3", "PK", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10456021": { "compartment": "compartment_20699", "id": "reaction_10456021", "reactome": "R-DME-977228", "name": "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_10454862" ], "products": [ "species_10456019", "species_727810" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "FBgn0035050" ] }, "reaction_10456000": { "compartment": "compartment_17963", "id": "reaction_10456000", "reactome": "R-DME-977071", "name": "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454561", "species_727815" ], "products": [ "species_727810", "species_10455998" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "FBgn0035050" ] }, "reaction_10463326": { "compartment": "compartment_984", "id": "reaction_10463326", "reactome": "R-DME-2022399", "name": "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10444709" ], "products": [ "species_10463316" ], "modifiers": [ [ "species_10463323", "catalyst" ] ], "additional_components": [ "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "Q9VFX0", "FBgn0038135" ] }, "reaction_10463254": { "compartment": "compartment_984", "id": "reaction_10463254", "reactome": "R-DME-2022398", "name": "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463066" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463251", "catalyst" ] ], "additional_components": [ "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10497644": { "compartment": "compartment_984", "id": "reaction_10497644", "reactome": "R-DME-9619024", "name": "CES1trimer hydrolyses ACEI pro-drugs to ACEIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_9619052" ], "products": [ "species_8878776", "species_9619021" ], "modifiers": [ [ "species_10478126", "catalyst" ] ], "additional_components": [ "P23654", "FBgn0004108" ] }, "reaction_10497585": { "compartment": "compartment_984", "id": "reaction_10497585", "reactome": "R-DME-9614933", "name": "ACEIs bind ACE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464707", "species_9614913" ], "products": [ "species_10464710" ], "modifiers": [], "additional_components": [ "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10463500": { "compartment": "compartment_984", "id": "reaction_10463500", "reactome": "R-DME-2022412", "name": "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463388" ], "products": [ "species_10463198" ], "modifiers": [ [ "species_10463497", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q7K485", "FBgn0029093", "Q9VQ13", "FBgn0051926", "A1Z9Q9", "FBgn0033933", "Q9VQ12", "FBgn0053128", "Q9VQ11", "FBgn0051928", "Q9VLK3", "FBgn0032049", "Q9VKP7", "FBgn0032303", "Q9VKP6", "FBgn0032304", "Q9VEK4", "FBgn0038506", "Q9W5G3", "FBgn0011822", "Q9VEK3", "FBgn0038507", "Q9VQ14", "FBgn0053128" ] }, "reaction_10463467": { "compartment": "compartment_984", "id": "reaction_10463467", "reactome": "R-DME-2022405", "name": "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10444709" ], "modifiers": [ [ "species_10463251", "catalyst" ], [ "species_188972", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10463464": { "compartment": "compartment_984", "id": "reaction_10463464", "reactome": "R-DME-2022403", "name": "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463388" ], "products": [ "species_10463198" ], "modifiers": [ [ "species_10463461", "catalyst" ], [ "species_10463461", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VKP7", "FBgn0032303", "Q9VQ12", "FBgn0053128", "Q9W5G3", "FBgn0011822", "Q7K485", "FBgn0029093", "Q9VKP6", "FBgn0032304", "Q9VQ11", "FBgn0051928", "Q9VQ14", "FBgn0053128", "A1Z9Q9", "FBgn0033933", "Q9VEK4", "FBgn0038506", "Q9VLK3", "FBgn0032049", "Q9VQ13", "FBgn0051926", "Q9VEK3", "FBgn0038507", "Q9VHG4", "FBgn0037671", "Q9VKP7", "FBgn0032303", "Q9VQ12", "FBgn0053128", "Q9W5G3", "FBgn0011822", "Q7K485", "FBgn0029093", "Q9VKP6", "FBgn0032304", "Q9VQ11", "FBgn0051928", "Q9VQ14", "FBgn0053128", "A1Z9Q9", "FBgn0033933", "Q9VEK4", "FBgn0038506", "Q9VLK3", "FBgn0032049", "Q9VQ13", "FBgn0051926", "Q9VEK3", "FBgn0038507", "Q9VHG4", "FBgn0037671" ] }, "reaction_10464744": { "compartment": "compartment_984", "id": "reaction_10464744", "reactome": "R-DME-2065357", "name": "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463388" ], "products": [ "species_10463198" ], "modifiers": [ [ "species_10464741", "catalyst" ], [ "species_2022362", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VEK3", "FBgn0038507", "Q9VQ14", "FBgn0053128", "Q7K485", "FBgn0029093", "Q9VQ13", "FBgn0051926", "A1Z9Q9", "FBgn0033933", "Q9VQ12", "FBgn0053128", "Q9VQ11", "FBgn0051928", "Q9VLK3", "FBgn0032049", "Q9VKP7", "FBgn0032303", "Q9VKP6", "FBgn0032304", "Q9VEK4", "FBgn0038506", "Q9W5G3", "FBgn0011822", "Q9VHG4", "FBgn0037671" ] }, "reaction_10464712": { "compartment": "compartment_984", "id": "reaction_10464712", "reactome": "R-DME-2065355", "name": "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10444709" ], "modifiers": [ [ "species_10464707", "catalyst" ], [ "species_188972", "catalyst" ], [ "species_10464710", "inhibitor" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076", "Q9VLJ6", "FBgn0016122", "Q9VJV2", "FBgn0032535", "Q8SXX2", "FBgn0032536", "Q10714", "FBgn0012037", "A1Z7M8", "FBgn0033366", "Q9W0Z1", "FBgn0035076" ] }, "reaction_10463237": { "compartment": "compartment_984", "id": "reaction_10463237", "reactome": "R-DME-2022396", "name": "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463133", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "FBgn0031081" ] }, "reaction_10463235": { "compartment": "compartment_984", "id": "reaction_10463235", "reactome": "R-DME-2022379", "name": "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10444709" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463230", "catalyst" ] ], "additional_components": [ "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "Q8SXX2", "FBgn0032536", "Q9W0Z1", "FBgn0035076", "Q10714", "FBgn0012037", "Q9VLJ6", "FBgn0016122", "A1Z7M8", "FBgn0033366", "Q9VJV2", "FBgn0032535" ] }, "reaction_10463233": { "compartment": "compartment_984", "id": "reaction_10463233", "reactome": "R-DME-2022378", "name": "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10463066" ], "modifiers": [ [ "species_10463230", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "Q8SXX2", "FBgn0032536", "Q9W0Z1", "FBgn0035076", "Q10714", "FBgn0012037", "Q9VLJ6", "FBgn0016122", "A1Z7M8", "FBgn0033366", "Q9VJV2", "FBgn0032535" ] }, "reaction_10464257": { "compartment": "compartment_984", "id": "reaction_10464257", "reactome": "R-DME-2028294", "name": "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463198" ], "products": [ "species_10463066" ], "modifiers": [ [ "species_10464254", "catalyst" ] ], "additional_components": [ "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "Q961J8", "FBgn0035781", "Q9VRZ3", "FBgn0035718", "Q9VX86", "FBgn0030815", "Q7JYV3", "FBgn0033774", "Q9VLZ2", "FBgn0031929", "Q9VS80", "FBgn0035791", "Q0E9F9", "FBgn0033241", "Q9VLZ1", "FBgn0031930", "Q9VS67", "FBgn0035780", "M9PEV1", "FBgn0035776", "Q9VL87", "FBgn0032143", "Q9VS66", "FBgn0035779", "Q9W478", "FBgn0029804", "Q9VL86", "FBgn0032144", "Q9VS65", "FBgn0052379", "Q9W477", "FBgn0259149", "Q9VCM8", "FBgn0039073", "Q9VS64", "FBgn0035777", "Q9W475", "FBgn0029807" ] }, "reaction_10463136": { "compartment": "compartment_984", "id": "reaction_10463136", "reactome": "R-DME-2022368", "name": "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10463066" ], "products": [ "species_10463128" ], "modifiers": [ [ "species_10463133", "catalyst" ] ], "additional_components": [ "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "FBgn0031081" ] }, "reaction_209224": { "compartment": "compartment_70101", "id": "reaction_209224", "reactome": "R-DME-209224", "name": "SLMB binds to and ubiquitinates phosphorylated CI", "reversible": "false", "notes": "Phosphorylated Cubitus Interruptus (CI) is now recognised by Slimb (SLMB), which is part of the SCF (Skp1, Cdc53, and F-box) ubiquitin ligase complex. CI associates with SLMB via its phosphorylated residues and is then ubiquitinated by the SCF ubiquitin ligase complex.", "reactants": [ "species_206204", "species_206766", "species_206788" ], "products": [ "species_207011" ], "modifiers": [ [ "species_207002", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209278": { "compartment": "compartment_70101", "id": "reaction_209278", "reactome": "R-DME-209278", "name": "Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex", "reversible": "false", "notes": "Ubiquitinated and phosphorylated Cubitus Interruptus (CI) is processed by the proteasome complex resulting in a truncated product, CI75, with a C-terminus somewhere between residues 650-700 (Aza-Blanc et al., 1997) or 611-760 (Methot and Basler, 1999). It is thought that the zinc-finger domain and C-terminal simple sequences arrest proteasome digestion from the C-terminus. Some CI is likely to be fully proteolysed by the proteasome.", "reactants": [ "species_207011" ], "products": [ "species_206204", "species_206171", "species_206788", "species_206900" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_10475099": { "compartment": "compartment_70101", "id": "reaction_10475099", "reactome": "R-DME-5654647", "name": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475094", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475096": { "compartment": "compartment_876", "id": "reaction_10475096", "reactome": "R-DME-5654646", "name": "Activated FGFR3:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475085" ], "products": [ "species_10475094" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475073": { "compartment": "compartment_70101", "id": "reaction_10475073", "reactome": "R-DME-5654625", "name": "Activated FGFR3 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465477", "species_10474909" ], "products": [ "species_10475071" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475088": { "compartment": "compartment_70101", "id": "reaction_10475088", "reactome": "R-DME-5654634", "name": "Activated FGFR3 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475071" ], "products": [ "species_29370", "species_10475085" ], "modifiers": [ [ "species_10475071", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475069": { "compartment": "compartment_70101", "id": "reaction_10475069", "reactome": "R-DME-5654623", "name": "Activated FGFR3 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474997", "species_10465477" ], "products": [ "species_10475067" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474925": { "compartment": "compartment_876", "id": "reaction_10474925", "reactome": "R-DME-5654408", "name": "Activated FGFR3 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474920" ], "products": [ "species_29370", "species_10465479" ], "modifiers": [ [ "species_10474920", "catalyst" ], [ "species_10474923", "inhibitor" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474939": { "compartment": "compartment_70101", "id": "reaction_10474939", "reactome": "R-DME-5654416", "name": "Activated FGFR3:pFRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474932", "species_10431797" ], "products": [ "species_10474934" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475083": { "compartment": "compartment_876", "id": "reaction_10475083", "reactome": "R-DME-5654631", "name": "Activated FGFR3 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475078" ], "products": [ "species_29370", "species_10475080" ], "modifiers": [ [ "species_10475078", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474937": { "compartment": "compartment_70101", "id": "reaction_10474937", "reactome": "R-DME-5654413", "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474934", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10493208": { "compartment": "compartment_70101", "id": "reaction_10493208", "reactome": "R-DME-8941628", "name": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475080", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475076": { "compartment": "compartment_876", "id": "reaction_10475076", "reactome": "R-DME-5654628", "name": "Activated FGFR3 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475067" ], "products": [ "species_10474930", "species_29370" ], "modifiers": [ [ "species_10475067", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474928": { "compartment": "compartment_70101", "id": "reaction_10474928", "reactome": "R-DME-5654409", "name": "Activated FGFR3 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465477", "species_10474873" ], "products": [ "species_10474920" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10474855": { "compartment": "compartment_876", "id": "reaction_10474855", "reactome": "R-DME-5654224", "name": "Activated FGFR3 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10465477", "species_10439290" ], "products": [ "species_10474850" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0003416", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_179838" ] }, "reaction_10474822": { "compartment": "compartment_876", "id": "reaction_10474822", "reactome": "R-DME-5654148", "name": "p-4Y-PLCG1 dissociates from activated FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474820" ], "products": [ "species_10465477", "species_10441915" ], "modifiers": [], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "FBgn0003416" ] }, "reaction_10474853": { "compartment": "compartment_70101", "id": "reaction_10474853", "reactome": "R-DME-5654222", "name": "Activated FGFR3 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474850", "species_113592" ], "products": [ "species_10474820", "species_29370" ], "modifiers": [ [ "species_10474850", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_179838", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "species_179838" ] }, "reaction_10475180": { "compartment": "compartment_70101", "id": "reaction_10475180", "reactome": "R-DME-5654709", "name": "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465509", "catalyst" ] ], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475177": { "compartment": "compartment_70101", "id": "reaction_10475177", "reactome": "R-DME-5654705", "name": "FGFR3-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465483", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475092": { "compartment": "compartment_70101", "id": "reaction_10475092", "reactome": "R-DME-5654641", "name": "Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465505", "species_10438945" ], "products": [ "species_10465507" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475090": { "compartment": "compartment_70101", "id": "reaction_10475090", "reactome": "R-DME-5654637", "name": "Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465479" ], "products": [ "species_10465481" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10488437": { "compartment": "compartment_17963", "id": "reaction_10488437", "reactome": "R-DME-8851619", "name": "GALNT3 transfers GalNAc to FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10488432" ], "products": [ "species_205687", "species_10488434" ], "modifiers": [ [ "species_10454602", "catalyst" ] ], "additional_components": [ "FBgn0014135", "FBgn0014135", "FBgn0034025" ] }, "reaction_10488439": { "compartment": "compartment_17963", "id": "reaction_10488439", "reactome": "R-DME-8851632", "name": "GalNAc-T178-FGF23(25-251) translocates from Golgi lumen to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488434" ], "products": [ "species_10433476" ], "modifiers": [], "additional_components": [ "FBgn0014135", "FBgn0014135" ] }, "reaction_10439768": { "compartment": "compartment_876", "id": "reaction_10439768", "reactome": "R-DME-190388", "name": "Autocatalytic phosphorylation of FGFR3c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439729", "species_113592" ], "products": [ "species_29370", "species_10433592" ], "modifiers": [ [ "species_10439729", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439731": { "compartment": "compartment_984", "id": "reaction_10439731", "reactome": "R-DME-190261", "name": "FGFR3c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433467", "species_10439725", "species_190915" ], "products": [ "species_10439729" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439743": { "compartment": "compartment_984", "id": "reaction_10439743", "reactome": "R-DME-190263", "name": "FGFR3b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439737", "species_190915", "species_10433471" ], "products": [ "species_10439741" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10439765": { "compartment": "compartment_876", "id": "reaction_10439765", "reactome": "R-DME-190385", "name": "Autocatalytic phosphorylation of FGFR3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439741" ], "products": [ "species_29370", "species_10433573" ], "modifiers": [ [ "species_10439741", "catalyst" ] ], "additional_components": [ "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "species_190915", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474991": { "compartment": "compartment_70101", "id": "reaction_10474991", "reactome": "R-DME-5654565", "name": "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474920" ], "products": [ "species_29370", "species_10474923" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "P40417", "FBgn0003256" ] }, "reaction_10475192": { "compartment": "compartment_70101", "id": "reaction_10475192", "reactome": "R-DME-5654730", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465505", "species_10439154" ], "products": [ "species_10475150" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10475155": { "compartment": "compartment_70101", "id": "reaction_10475155", "reactome": "R-DME-5654679", "name": "CBL ubiquitinates FRS2 and FGFR3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10475150" ], "products": [ "species_10475152" ], "modifiers": [ [ "species_10475150", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896" ] }, "reaction_10439771": { "compartment": "compartment_876", "id": "reaction_10439771", "reactome": "R-DME-190408", "name": "Autocatalytic phosphorylation of FGFR2b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439717", "species_113592" ], "products": [ "species_29370", "species_10433531" ], "modifiers": [ [ "species_10439717", "catalyst" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439719": { "compartment": "compartment_876", "id": "reaction_10439719", "reactome": "R-DME-190260", "name": "FGFR2b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433429", "species_10439670", "species_190915" ], "products": [ "species_10439717" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0014135", "FBgn0285896", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439774": { "compartment": "compartment_876", "id": "reaction_10439774", "reactome": "R-DME-190413", "name": "Autocatalytic phosphorylation of FGFR2c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439703" ], "products": [ "species_10433553", "species_29370" ], "modifiers": [ [ "species_10439703", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896" ] }, "reaction_10439705": { "compartment": "compartment_876", "id": "reaction_10439705", "reactome": "R-DME-190258", "name": "FGFR2c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439691", "species_10433467", "species_190915" ], "products": [ "species_10439703" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0285896", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896" ] }, "reaction_10475065": { "compartment": "compartment_876", "id": "reaction_10475065", "reactome": "R-DME-5654620", "name": "Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465499" ], "products": [ "species_10465501" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475174": { "compartment": "compartment_70101", "id": "reaction_10475174", "reactome": "R-DME-5654701", "name": "FGFR2-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465475", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475171": { "compartment": "compartment_70101", "id": "reaction_10475171", "reactome": "R-DME-5654697", "name": "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465503", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475056": { "compartment": "compartment_876", "id": "reaction_10475056", "reactome": "R-DME-5654612", "name": "Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465471" ], "products": [ "species_10465473" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475054": { "compartment": "compartment_876", "id": "reaction_10475054", "reactome": "R-DME-5654607", "name": "Activated FGFR2 phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475049" ], "products": [ "species_29370", "species_10475051" ], "modifiers": [ [ "species_10475049", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474893": { "compartment": "compartment_70101", "id": "reaction_10474893", "reactome": "R-DME-5654399", "name": "Activated FGFR2 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474873", "species_10465469" ], "products": [ "species_10474875" ], "modifiers": [], "additional_components": [ "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042" ] }, "reaction_10493202": { "compartment": "compartment_70101", "id": "reaction_10493202", "reactome": "R-DME-8941618", "name": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475051", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474890": { "compartment": "compartment_876", "id": "reaction_10474890", "reactome": "R-DME-5654397", "name": "Activated FGFR2 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474875" ], "products": [ "species_29370", "species_10465471" ], "modifiers": [ [ "species_10474875", "catalyst" ], [ "species_10474888", "inhibitor" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042" ] }, "reaction_10475063": { "compartment": "compartment_70101", "id": "reaction_10475063", "reactome": "R-DME-5654618", "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475058", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10475060": { "compartment": "compartment_70101", "id": "reaction_10475060", "reactome": "R-DME-5654615", "name": "Activated FGFR2:pFRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10475047" ], "products": [ "species_10475058" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474907": { "compartment": "compartment_70101", "id": "reaction_10474907", "reactome": "R-DME-5654402", "name": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474904", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474918": { "compartment": "compartment_70101", "id": "reaction_10474918", "reactome": "R-DME-5654407", "name": "Activated FGFR2 phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474911" ], "products": [ "species_29370", "species_10474902" ], "modifiers": [ [ "species_10474911", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474915": { "compartment": "compartment_876", "id": "reaction_10474915", "reactome": "R-DME-5654406", "name": "Activated FGFR2:p-SHC1 binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10474902" ], "products": [ "species_10474904" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10474913": { "compartment": "compartment_70101", "id": "reaction_10474913", "reactome": "R-DME-5654404", "name": "Activated FGFR2 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474909", "species_10465469" ], "products": [ "species_10474911" ], "modifiers": [], "additional_components": [ "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474840": { "compartment": "compartment_876", "id": "reaction_10474840", "reactome": "R-DME-5654159", "name": "Activated FGFR2 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10439290", "species_10465469" ], "products": [ "species_10474813" ], "modifiers": [], "additional_components": [ "FBgn0003416", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474838": { "compartment": "compartment_876", "id": "reaction_10474838", "reactome": "R-DME-5654157", "name": "p-4Y-PLCG1 dissociates from activated FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474815" ], "products": [ "species_10441915", "species_10465469" ], "modifiers": [], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "FBgn0003416", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474818": { "compartment": "compartment_70101", "id": "reaction_10474818", "reactome": "R-DME-5654147", "name": "Activated FGFR2 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474813" ], "products": [ "species_29370", "species_10474815" ], "modifiers": [ [ "species_10474813", "catalyst" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_179838", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VXH3", "FBgn0003416", "species_179838" ] }, "reaction_10474989": { "compartment": "compartment_70101", "id": "reaction_10474989", "reactome": "R-DME-5654562", "name": "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474875" ], "products": [ "species_29370", "species_10474888" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "P40417", "FBgn0003256" ] }, "reaction_10475148": { "compartment": "compartment_70101", "id": "reaction_10475148", "reactome": "R-DME-5654677", "name": "CBL ubiquitinates FRS2 and FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475143", "species_10426987" ], "products": [ "species_10475145" ], "modifiers": [ [ "species_10475143", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10475190": { "compartment": "compartment_70101", "id": "reaction_10475190", "reactome": "R-DME-5654729", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439154", "species_10465499" ], "products": [ "species_10475143" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10485933": { "compartment": "compartment_7660", "id": "reaction_10485933", "reactome": "R-DME-6803527", "name": "ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485901", "species_10485929", "species_10485927", "species_10485894", "species_10429340", "species_10485922" ], "products": [ "species_10485931" ], "modifiers": [], "additional_components": [ "Q9VGH5", "FBgn0259139", "Q9W0D6", "FBgn0035235", "M9NFQ7", "FBgn0052062", "FBgn0023441", "FBgn0023441", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "FBgn0267790", "A8JPX0", "FBgn0085383", "E1JIZ9", "FBgn0085391", "Q8IMX4", "FBgn0005649", "A8JPX0", "FBgn0085383", "E1JIZ9", "FBgn0085391", "Q8IMX4", "FBgn0005649", "Q9VHC7", "FBgn0267790", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9BJZ5", "FBgn0023441", "Q9VGH5", "FBgn0259139", "Q9W0D6", "FBgn0035235", "M9NFQ7", "FBgn0052062" ] }, "reaction_10474976": { "compartment": "compartment_876", "id": "reaction_10474976", "reactome": "R-DME-5654511", "name": "FGFRL1 dimer binds FGFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433429", "species_10474972", "species_190915" ], "products": [ "species_10474974" ], "modifiers": [], "additional_components": [ "FBgn0014135", "Q9I7U4", "FBgn0086906", "species_190915", "Q9I7U4", "FBgn0086906", "Q9VDT9", "FBgn0014135" ] }, "reaction_10474987": { "compartment": "compartment_70101", "id": "reaction_10474987", "reactome": "R-DME-5654560", "name": "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474982" ], "products": [ "species_29370", "species_10474984" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "P40417", "FBgn0003256" ] }, "reaction_10475141": { "compartment": "compartment_70101", "id": "reaction_10475141", "reactome": "R-DME-5654673", "name": "p-CBL:GRB2 binds p-FRS2:activated FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439154", "species_10465493" ], "products": [ "species_10475134" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10475139": { "compartment": "compartment_70101", "id": "reaction_10475139", "reactome": "R-DME-5654672", "name": "CBL ubiquitinates FRS2 and FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10475134" ], "products": [ "species_10475136" ], "modifiers": [ [ "species_10475134", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10474978": { "compartment": "compartment_876", "id": "reaction_10474978", "reactome": "R-DME-5654514", "name": "KAL1 binds FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439681", "species_10439672" ], "products": [ "species_10439683" ], "modifiers": [], "additional_components": [ "FBgn0039155", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VCC7", "FBgn0039155" ] }, "reaction_10439666": { "compartment": "compartment_984", "id": "reaction_10439666", "reactome": "R-DME-190245", "name": "FGFR1b binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433429", "species_10439660", "species_190915" ], "products": [ "species_10439664" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439777": { "compartment": "compartment_876", "id": "reaction_10439777", "reactome": "R-DME-190427", "name": "Autocatalytic phosphorylation of FGFR1b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439664", "species_113592" ], "products": [ "species_29370", "species_10433465" ], "modifiers": [ [ "species_10439664", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "species_190915", "Q07407", "FBgn0010389", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135" ] }, "reaction_10439687": { "compartment": "compartment_984", "id": "reaction_10439687", "reactome": "R-DME-190256", "name": "FGFR1c binds to FGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439672", "species_10433467", "species_190915" ], "products": [ "species_10439676" ], "modifiers": [ [ "species_190915", "catalyst" ], [ "species_10439685", "catalyst" ], [ "species_10439683", "inhibitor" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "FBgn0014135", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VCC7", "FBgn0039155", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VCC7", "FBgn0039155" ] }, "reaction_10439780": { "compartment": "compartment_876", "id": "reaction_10439780", "reactome": "R-DME-190429", "name": "Autocatalytic phosphorylation of FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439676" ], "products": [ "species_29370", "species_10433484" ], "modifiers": [ [ "species_10439676", "catalyst" ] ], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474980": { "compartment": "compartment_984", "id": "reaction_10474980", "reactome": "R-DME-5654515", "name": "KAL1 binds HS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439681", "species_190915" ], "products": [ "species_10439685" ], "modifiers": [], "additional_components": [ "FBgn0039155", "species_190915", "Q9VCC7", "FBgn0039155" ] }, "reaction_10439759": { "compartment": "compartment_984", "id": "reaction_10439759", "reactome": "R-DME-190268", "name": "FGFR1c binds to Klotho-bound FGF23", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439672", "species_190915", "species_10433503" ], "products": [ "species_10439757" ], "modifiers": [ [ "species_190915", "catalyst" ] ], "additional_components": [ "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10439920": { "compartment": "compartment_876", "id": "reaction_10439920", "reactome": "R-DME-191062", "name": "Autocatalytic phosphorylation of Klotho-bound FGFR1c", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439757" ], "products": [ "species_10433505", "species_29370" ], "modifiers": [ [ "species_10439757", "catalyst" ] ], "additional_components": [ "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VDT9", "FBgn0014135", "Q9VV98", "FBgn0036659", "species_190915", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389" ] }, "reaction_10474846": { "compartment": "compartment_876", "id": "reaction_10474846", "reactome": "R-DME-5654167", "name": "Activated FGFR1 binds PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10465461", "species_10439290" ], "products": [ "species_10474824" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0003416", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_179838" ] }, "reaction_10474829": { "compartment": "compartment_70101", "id": "reaction_10474829", "reactome": "R-DME-5654149", "name": "Activated FGFR1 phosphorylates PLCG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474824" ], "products": [ "species_29370", "species_10474826" ], "modifiers": [ [ "species_10474824", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_179838", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_179838" ] }, "reaction_10474844": { "compartment": "compartment_876", "id": "reaction_10474844", "reactome": "R-DME-5654165", "name": "p-4Y-PLCG1 dissociates from activated FGFR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474826" ], "products": [ "species_10465461", "species_10441915" ], "modifiers": [], "additional_components": [ "Q9VXH3", "FBgn0003416", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0003416" ] }, "reaction_10475309": { "compartment": "compartment_876", "id": "reaction_10475309", "reactome": "R-DME-5656064", "name": "Activated FGFR1 binds FLRT1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475301", "species_10465461" ], "products": [ "species_10475307" ], "modifiers": [], "additional_components": [ "FBgn0028872", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "M9MSI4", "FBgn0028872", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475018": { "compartment": "compartment_70101", "id": "reaction_10475018", "reactome": "R-DME-5654586", "name": "Activated FGFR1:p-FRS binds GRB2:SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474866", "species_10431797" ], "products": [ "species_10474868" ], "modifiers": [], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10493205": { "compartment": "compartment_70101", "id": "reaction_10493205", "reactome": "R-DME-8941623", "name": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475022", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475001": { "compartment": "compartment_70101", "id": "reaction_10475001", "reactome": "R-DME-5654571", "name": "Activated FGFR1 binds FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465461", "species_10474997" ], "products": [ "species_10474999" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10474871": { "compartment": "compartment_70101", "id": "reaction_10474871", "reactome": "R-DME-5654392", "name": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10474868", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10474995": { "compartment": "compartment_70101", "id": "reaction_10474995", "reactome": "R-DME-5654569", "name": "Activated FGFR1 binds FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465461", "species_10474873" ], "products": [ "species_10474982" ], "modifiers": [], "additional_components": [ "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "FBgn0032042", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475011": { "compartment": "compartment_876", "id": "reaction_10475011", "reactome": "R-DME-5654578", "name": "Activated FGFR1 phosphorylates FRS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474999" ], "products": [ "species_10474864", "species_29370" ], "modifiers": [ [ "species_10474999", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475025": { "compartment": "compartment_876", "id": "reaction_10475025", "reactome": "R-DME-5654587", "name": "Activated FGFR1:p-FRS phosphorylates PPTN11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475020" ], "products": [ "species_29370", "species_10475022" ], "modifiers": [ [ "species_10475020", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475008": { "compartment": "compartment_876", "id": "reaction_10475008", "reactome": "R-DME-5654575", "name": "Activated FGFR1 phosphorylates FRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474982" ], "products": [ "species_29370", "species_10465463" ], "modifiers": [ [ "species_10474982", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10475165": { "compartment": "compartment_70101", "id": "reaction_10475165", "reactome": "R-DME-5654690", "name": "FGFR1-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465467", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475029": { "compartment": "compartment_70101", "id": "reaction_10475029", "reactome": "R-DME-5654594", "name": "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465493" ], "products": [ "species_10465495" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475027": { "compartment": "compartment_70101", "id": "reaction_10475027", "reactome": "R-DME-5654592", "name": "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438945", "species_10465463" ], "products": [ "species_10465465" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10475168": { "compartment": "compartment_70101", "id": "reaction_10475168", "reactome": "R-DME-5654692", "name": "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465497", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10459327": { "compartment": "compartment_876", "id": "reaction_10459327", "reactome": "R-DME-1470009", "name": "Phosphorylation of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10459159" ], "products": [ "species_29370", "species_10459324" ], "modifiers": [ [ "species_10459159", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop" ] }, "reaction_10498528": { "compartment": "compartment_876", "id": "reaction_10498528", "reactome": "R-DME-9681375", "name": "KIT binds ripretinib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442600", "species_9674322" ], "products": [ "species_10498526" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10498434": { "compartment": "compartment_876", "id": "reaction_10498434", "reactome": "R-DME-9669854", "name": "KIT binds type II TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9669722", "species_10442600" ], "products": [ "species_10498432" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10459164": { "compartment": "compartment_876", "id": "reaction_10459164", "reactome": "R-DME-1433471", "name": "Activation of RAS by p-KIT bound SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10442628", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10459161": { "compartment": "compartment_876", "id": "reaction_10459161", "reactome": "R-DME-1433456", "name": "Recruitment of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445861", "species_10459141" ], "products": [ "species_10459159" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop" ] }, "reaction_10459128": { "compartment": "compartment_70101", "id": "reaction_10459128", "reactome": "R-DME-1433415", "name": "Activation of RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_428485" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10459125", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "species_179838", "Q9NHV9", "FBgn0040068" ] }, "reaction_10459144": { "compartment": "compartment_876", "id": "reaction_10459144", "reactome": "R-DME-1433418", "name": "Phosphorylation of JAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459136", "species_113592" ], "products": [ "species_29370", "species_10459141" ], "modifiers": [ [ "species_10459136", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop" ] }, "reaction_10459335": { "compartment": "compartment_876", "id": "reaction_10459335", "reactome": "R-DME-1470012", "name": "Disassociation and translocation of STATs to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459329" ], "products": [ "species_10458565", "species_10459141" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop", "Q24151", "Stat92E", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop" ] }, "reaction_10459157": { "compartment": "compartment_876", "id": "reaction_10459157", "reactome": "R-DME-1433423", "name": "PTP-RO interacts with p-c-Kit complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459153", "species_10442600" ], "products": [ "species_10459155" ], "modifiers": [], "additional_components": [ "Q9VJ95", "FBgn0267486", "A1ZAB3", "FBgn0034085", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ95", "FBgn0267486", "A1ZAB3", "FBgn0034085" ] }, "reaction_10459331": { "compartment": "compartment_876", "id": "reaction_10459331", "reactome": "R-DME-1470010", "name": "Dimerization of STATs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459324" ], "products": [ "species_10459329" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24151", "Stat92E", "Q24592", "phospho-hop", "Q24151", "Stat92E", "P00528", "FBgn0262733", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q24592", "phospho-hop" ] }, "reaction_10459179": { "compartment": "compartment_876", "id": "reaction_10459179", "reactome": "R-DME-1433508", "name": "PKC alpha interacts with and phosphorylates KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434436", "species_113592", "species_10442600" ], "products": [ "species_29370", "species_10459176" ], "modifiers": [ [ "species_10434436", "catalyst" ] ], "additional_components": [ "FBgn0003091", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "P05130", "FBgn0003091", "FBgn0003091" ] }, "reaction_10442632": { "compartment": "compartment_876", "id": "reaction_10442632", "reactome": "R-DME-205244", "name": "Recruitment of CBL to KIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442628", "species_10439032" ], "products": [ "species_10442630" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "FBgn0020224", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10458441": { "compartment": "compartment_70101", "id": "reaction_10458441", "reactome": "R-DME-1250383", "name": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10458438", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9V3C8", "FBgn0015296" ] }, "reaction_10458591": { "compartment": "compartment_7660", "id": "reaction_10458591", "reactome": "R-DME-1254386", "name": "ERBB4s80 forms a complex with estrogen receptor ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458515", "species_10458587" ], "products": [ "species_10458589" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "species_374146", "Q8WS79", "FBgn0035849", "species_374146", "Q8WS79", "FBgn0035849", "P04412", "FBgn0003731" ] }, "reaction_10458540": { "compartment": "compartment_70101", "id": "reaction_10458540", "reactome": "R-DME-1253343", "name": "WWOX binds ERBB4s80", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466", "species_10458536" ], "products": [ "species_10458538" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "FBgn0031972", "Q9VLU5", "FBgn0031972", "P04412", "FBgn0003731" ] }, "reaction_10458571": { "compartment": "compartment_70101", "id": "reaction_10458571", "reactome": "R-DME-1254291", "name": "ERBB4s80 binds STAT5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466", "species_10458559" ], "products": [ "species_10458561" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "Q24151", "Stat92E", "Q24151", "Stat92E", "P04412", "FBgn0003731" ] }, "reaction_10458554": { "compartment": "compartment_70101", "id": "reaction_10458554", "reactome": "R-DME-1254251", "name": "ERBB4s80 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544", "species_10458466" ], "products": [ "species_10458546" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q45VV3", "yki" ] }, "reaction_10458505": { "compartment": "compartment_70101", "id": "reaction_10458505", "reactome": "R-DME-1251997", "name": "Cleavage of ERBB4m80 by gamma-scretase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458456" ], "products": [ "species_10458466" ], "modifiers": [ [ "species_10458502", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9VQG2", "FBgn0031458", "Q86BE9", "FBgn0053198", "O02194", "FBgn0284421", "Q9VC27", "FBgn0039234" ] }, "reaction_10458569": { "compartment": "compartment_70101", "id": "reaction_10458569", "reactome": "R-DME-1254285", "name": "ERBB4s80:STAT5A complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458561" ], "products": [ "species_10458567" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "P04412", "FBgn0003731", "Q24151", "Stat92E", "P04412", "FBgn0003731" ] }, "reaction_10458552": { "compartment": "compartment_70101", "id": "reaction_10458552", "reactome": "R-DME-1254248", "name": "Translocation of ERBB4s80:YAP1 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458546" ], "products": [ "species_10458550" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "Q45VV3", "yki", "Q45VV3", "yki", "P04412", "FBgn0003731" ] }, "reaction_10458519": { "compartment": "compartment_70101", "id": "reaction_10458519", "reactome": "R-DME-1252013", "name": "Translocation of ERBB4s80 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466" ], "products": [ "species_10458515" ], "modifiers": [ [ "species_10458517", "inhibitor" ] ], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731", "P00528", "FBgn0262733", "P04412", "FBgn0003731" ] }, "reaction_10458583": { "compartment": "compartment_70101", "id": "reaction_10458583", "reactome": "R-DME-1254376", "name": "Translocation of cytosolic ERBB4s80 to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466" ], "products": [ "species_10458581" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "P04412", "FBgn0003731" ] }, "reaction_10462454": { "compartment": "compartment_70101", "id": "reaction_10462454", "reactome": "R-DME-1977296", "name": "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10462447" ], "products": [ "species_10462451" ], "modifiers": [ [ "species_10462447", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174" ] }, "reaction_10458531": { "compartment": "compartment_876", "id": "reaction_10458531", "reactome": "R-DME-1253300", "name": "ERBB4 binds WWP1/ITCH ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456500", "species_10458522" ], "products": [ "species_10458524" ], "modifiers": [], "additional_components": [ "FBgn0003557", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10458529": { "compartment": "compartment_70101", "id": "reaction_10458529", "reactome": "R-DME-1253282", "name": "ERBB4 ubiquitination by WWP1/ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10458524" ], "products": [ "species_10458526" ], "modifiers": [ [ "species_10458524", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557", "P04412", "FBgn0003731", "Q9Y0H4", "FBgn0003557" ] }, "reaction_10462449": { "compartment": "compartment_70101", "id": "reaction_10462449", "reactome": "R-DME-1973956", "name": "NEDD4 binds ERBB4jmAcyt1s80 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456484", "species_10458460" ], "products": [ "species_10462447" ], "modifiers": [], "additional_components": [ "FBgn0259174", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "Q9VVI3", "FBgn0259174" ] }, "reaction_10497518": { "compartment": "compartment_876", "id": "reaction_10497518", "reactome": "R-DME-9612219", "name": "ERBB4s80 binds to SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458466", "species_10444503" ], "products": [ "species_10458517" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "FBgn0262733", "P00528", "FBgn0262733", "P04412", "FBgn0003731" ] }, "reaction_10476599": { "compartment": "compartment_70101", "id": "reaction_10476599", "reactome": "R-DME-5685366", "name": "GRB2-1:SOS1 binds p-Y-SHC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475810", "species_10431797" ], "products": [ "species_10475816" ], "modifiers": [], "additional_components": [ "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9V3C8", "FBgn0015296" ] }, "reaction_10437918": { "compartment": "compartment_876", "id": "reaction_10437918", "reactome": "R-DME-170986", "name": "Ral-GDS binds to Ras-GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10437914" ], "products": [ "species_10437916" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "FBgn0026376", "M9PCE9", "FBgn0026376", "species_29438", "P08646", "RAS85D" ] }, "reaction_10497488": { "compartment": "compartment_70101", "id": "reaction_10497488", "reactome": "R-DME-9610166", "name": "p-T,Y MAPK dimers translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458636" ], "products": [ "species_10440935" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10497474": { "compartment": "compartment_74700", "id": "reaction_10497474", "reactome": "R-DME-9610153", "name": "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10497463" ], "products": [ "species_10497467", "species_29370" ], "modifiers": [ [ "species_10497463", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1" ] }, "reaction_10497478": { "compartment": "compartment_70101", "id": "reaction_10497478", "reactome": "R-DME-9610154", "name": "Dissociation of phosphorylated MAP2Ks and MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497476" ], "products": [ "species_10475873", "species_10497461", "species_10433771" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "FBgn0003256" ] }, "reaction_10497465": { "compartment": "compartment_74700", "id": "reaction_10497465", "reactome": "R-DME-9610152", "name": "Activated BRAF recruits MAP2Ks and MAPKs to the endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475906", "species_10497461", "species_10433742" ], "products": [ "species_10497463" ], "modifiers": [], "additional_components": [ "Q24324", "phospho-Dsor1", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "FBgn0003256", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1" ] }, "reaction_10497481": { "compartment": "compartment_70101", "id": "reaction_10497481", "reactome": "R-DME-9610156", "name": "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497467", "species_113592" ], "products": [ "species_29370", "species_10497476" ], "modifiers": [ [ "species_10497467", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "Q24324", "phospho-Dsor1" ] }, "reaction_10475989": { "compartment": "compartment_70101", "id": "reaction_10475989", "reactome": "R-DME-5674385", "name": "p-T,Y MAPKs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433771" ], "products": [ "species_10458636" ], "modifiers": [], "additional_components": [ "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10497486": { "compartment": "compartment_74700", "id": "reaction_10497486", "reactome": "R-DME-9610163", "name": "BRAF autophosphorylates downstream of RAP1 and NGF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497483", "species_113592" ], "products": [ "species_29370", "species_10497461" ], "modifiers": [ [ "species_10497483", "catalyst" ] ], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta", "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "species_1562550", "P29310", "14-3-3zeta" ] }, "reaction_10438835": { "compartment": "compartment_984", "id": "reaction_10438835", "reactome": "R-DME-177479", "name": "Axonal transport of NGF:Trk complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438827" ], "products": [ "species_10438827" ], "modifiers": [ [ "species_10438832", "catalyst" ] ], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q8T390", "FBgn0038659", "FBgn0033687" ] }, "reaction_10440762": { "compartment": "compartment_947587", "id": "reaction_10440762", "reactome": "R-DME-198266", "name": "PI3K produces PIP3 and other phosphatidyl inositides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10440759", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9XTN2", "chico" ] }, "reaction_10441962": { "compartment": "compartment_876", "id": "reaction_10441962", "reactome": "R-DME-202692", "name": "PIP3 binds to RhoA and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10434902" ], "products": [ "species_10441960" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_179838" ] }, "reaction_10431807": { "compartment": "compartment_70101", "id": "reaction_10431807", "reactome": "R-DME-74736", "name": "GRB2-1:SOS1 binds p-IRS1,p-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10431801" ], "products": [ "species_10431805" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10433706": { "compartment": "compartment_876", "id": "reaction_10433706", "reactome": "R-DME-109701", "name": "PDPK1 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10433702" ], "products": [ "species_10433704" ], "modifiers": [], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10433715": { "compartment": "compartment_70101", "id": "reaction_10433715", "reactome": "R-DME-109702", "name": "PDPK1 phosphorylates AKT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433696", "species_113592" ], "products": [ "species_10433712", "species_29370" ], "modifiers": [ [ "species_10433704", "catalyst" ] ], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "Q8INB9", "phospho-Akt1", "species_179838", "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10433698": { "compartment": "compartment_876", "id": "reaction_10433698", "reactome": "R-DME-109700", "name": "AKT2 binds PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10433694" ], "products": [ "species_10433696", "species_10433688" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "Q9V3Z1", "FBgn0028978", "Q8INB9", "phospho-Akt1", "species_179838", "FBgn0028978" ] }, "reaction_10433683": { "compartment": "compartment_70101", "id": "reaction_10433683", "reactome": "R-DME-109699", "name": "PI3K-containing complexes phosphorylate PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10433680", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9XTN2", "chico", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VLL4", "FBgn0032042", "species_190915", "Q9VDT9", "FBgn0014135", "Q09147", "FBgn0285896", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659" ] }, "reaction_10431824": { "compartment": "compartment_70101", "id": "reaction_10431824", "reactome": "R-DME-74737", "name": "p-Y-IRS1,p-Y-IRS2 bind PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431801", "species_10431820" ], "products": [ "species_10431822" ], "modifiers": [], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9XTN2", "chico" ] }, "reaction_10431786": { "compartment": "compartment_876", "id": "reaction_10431786", "reactome": "R-DME-74734", "name": "Re-integration of insulin receptor into plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431784" ], "products": [ "species_10431589" ], "modifiers": [], "additional_components": [ "P09208", "InR", "P09208", "InR" ] }, "reaction_10431768": { "compartment": "compartment_17940", "id": "reaction_10431768", "reactome": "R-DME-74723", "name": "Endosome acidification", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_74722" ], "modifiers": [ [ "species_10431765", "catalyst" ] ], "additional_components": [ "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q7JR49", "FBgn0262515" ] }, "reaction_10471490": { "compartment": "compartment_171062", "id": "reaction_10471490", "reactome": "R-DME-5252133", "name": "ATP6AP1 binds V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431763", "species_10431758" ], "products": [ "species_10431765" ], "modifiers": [], "additional_components": [ "FBgn0262515", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q7JR49", "FBgn0262515" ] }, "reaction_10433749": { "compartment": "compartment_70101", "id": "reaction_10433749", "reactome": "R-DME-109823", "name": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10431805" ], "products": [ "species_10433747", "species_29370" ], "modifiers": [ [ "species_10433740", "catalyst" ] ], "additional_components": [ "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0003256" ] }, "reaction_10476611": { "compartment": "compartment_70101", "id": "reaction_10476611", "reactome": "R-DME-5686315", "name": "GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433747" ], "products": [ "species_10433733", "species_10431801" ], "modifiers": [], "additional_components": [ "Q9XTN2", "chico", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10433745": { "compartment": "compartment_70101", "id": "reaction_10433745", "reactome": "R-DME-109822", "name": "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10431832" ], "products": [ "species_29370", "species_10433735" ], "modifiers": [ [ "species_10433740", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0003256" ] }, "reaction_10476609": { "compartment": "compartment_70101", "id": "reaction_10476609", "reactome": "R-DME-5686074", "name": "GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433735" ], "products": [ "species_10433733", "species_10431830" ], "modifiers": [], "additional_components": [ "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296" ] }, "reaction_10433725": { "compartment": "compartment_70101", "id": "reaction_10433725", "reactome": "R-DME-109813", "name": "GRB2-1 binds SOS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431795", "species_10431791" ], "products": [ "species_10431797" ], "modifiers": [], "additional_components": [ "FBgn0004638", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10431834": { "compartment": "compartment_70101", "id": "reaction_10431834", "reactome": "R-DME-74746", "name": "GRB2-1:SOS1 binds p-Y427-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10431830" ], "products": [ "species_10431832" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10446431": { "compartment": "compartment_70101", "id": "reaction_10446431", "reactome": "R-DME-389083", "name": "Autophosphorylation of PDGF alpha receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10446424" ], "products": [ "species_29370", "species_10446426" ], "modifiers": [ [ "species_10446424", "catalyst" ], [ "species_10446429", "inhibitor" ] ], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964" ] }, "reaction_10489777": { "compartment": "compartment_984", "id": "reaction_10489777", "reactome": "R-DME-8865276", "name": "PDGF-AB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446192" ], "products": [ "species_10489771", "species_10439284", "species_10439338" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "FBgn0030964", "Q9VWP6", "FBgn0030964", "FBgn0030964", "FBgn0004509" ] }, "reaction_10446204": { "compartment": "compartment_20699", "id": "reaction_10446204", "reactome": "R-DME-382053", "name": "Translocation of PDGF from ER to Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446186" ], "products": [ "species_10446202" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964" ] }, "reaction_10439340": { "compartment": "compartment_984", "id": "reaction_10439340", "reactome": "R-DME-186785", "name": "PDGF-AA clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439336" ], "products": [ "species_10439338", "species_10439276" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "FBgn0030964", "Q9VWP6", "FBgn0030964", "FBgn0004509" ] }, "reaction_10439324": { "compartment": "compartment_876", "id": "reaction_10439324", "reactome": "R-DME-186773", "name": "PDGF dimer binds two receptors simultaneously", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439286", "species_10439308" ], "products": [ "species_10439318" ], "modifiers": [ [ "species_10439320", "inhibitor" ], [ "species_10439322", "inhibitor" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10498453": { "compartment": "compartment_876", "id": "reaction_10498453", "reactome": "R-DME-9674093", "name": "PDGFRs bind type I TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9674075", "species_10446424" ], "products": [ "species_10446429" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964" ] }, "reaction_10446441": { "compartment": "compartment_70101", "id": "reaction_10446441", "reactome": "R-DME-389086", "name": "Autophosphorylation of PDGF alpha/beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446436", "species_113592" ], "products": [ "species_29370", "species_10446438" ], "modifiers": [ [ "species_10446436", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10498455": { "compartment": "compartment_876", "id": "reaction_10498455", "reactome": "R-DME-9674095", "name": "PDGFRs bind type II TKI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9674079", "species_10439308" ], "products": [ "species_10439320" ], "modifiers": [], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006" ] }, "reaction_10439359": { "compartment": "compartment_70101", "id": "reaction_10439359", "reactome": "R-DME-186800", "name": "PI3K catalyses the phosphorylation of PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10439328", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10439294": { "compartment": "compartment_876", "id": "reaction_10439294", "reactome": "R-DME-186765", "name": "PLC-gamma binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439288", "species_10439290" ], "products": [ "species_10439292" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "FBgn0003416", "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10439356": { "compartment": "compartment_70101", "id": "reaction_10439356", "reactome": "R-DME-186798", "name": "GAP binds to PDGF-beta receptors only", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439344", "species_10439352" ], "products": [ "species_10439354" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "FBgn0003969", "Q8IR23", "FBgn0003969", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10445851": { "compartment": "compartment_70101", "id": "reaction_10445851", "reactome": "R-DME-380780", "name": "Activation of Src", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439361", "species_113592" ], "products": [ "species_29370", "species_10445848" ], "modifiers": [ [ "species_10439361", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P00528", "FBgn0262733" ] }, "reaction_10446232": { "compartment": "compartment_70101", "id": "reaction_10446232", "reactome": "R-DME-382058", "name": "Nck binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444486", "species_10439288" ], "products": [ "species_10446230" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VPU1", "dock" ] }, "reaction_10446164": { "compartment": "compartment_70101", "id": "reaction_10446164", "reactome": "R-DME-382052", "name": "p130Cas and C3G bind PDGFR bound Crk", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446160", "species_10446150", "species_10446155" ], "products": [ "species_10446162" ], "modifiers": [], "additional_components": [ "FBgn0259228", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9XYM0", "FBgn0024811", "FBgn0035101", "A4IJ58", "FBgn0035101", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9XYM0", "FBgn0024811", "O77086", "FBgn0259228" ] }, "reaction_10459917": { "compartment": "compartment_876", "id": "reaction_10459917", "reactome": "R-DME-1524186", "name": "Phosphorylation of PLCgamma by PDGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439292" ], "products": [ "species_29370", "species_10459912" ], "modifiers": [ [ "species_10439292", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10445867": { "compartment": "compartment_70101", "id": "reaction_10445867", "reactome": "R-DME-380782", "name": "STAT binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439288", "species_10445855" ], "products": [ "species_10445865" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q24151", "Stat92E", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10459914": { "compartment": "compartment_876", "id": "reaction_10459914", "reactome": "R-DME-1524182", "name": "Activated PLC gamma dissociates from the PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459912" ], "products": [ "species_10439288", "species_10441915" ], "modifiers": [], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "FBgn0003416" ] }, "reaction_10439370": { "compartment": "compartment_70101", "id": "reaction_10439370", "reactome": "R-DME-186834", "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10439365", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10439367": { "compartment": "compartment_70101", "id": "reaction_10439367", "reactome": "R-DME-186826", "name": "GRB2:SOS1 complex binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10439288" ], "products": [ "species_10439365" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10446214": { "compartment": "compartment_70101", "id": "reaction_10446214", "reactome": "R-DME-382056", "name": "Crk binds to the active PDGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446146", "species_10439288" ], "products": [ "species_10446150" ], "modifiers": [], "additional_components": [ "FBgn0024811", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9XYM0", "FBgn0024811" ] }, "reaction_10439363": { "compartment": "compartment_876", "id": "reaction_10439363", "reactome": "R-DME-186819", "name": "SH2 domain of Src binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438881", "species_10439288" ], "products": [ "species_10439361" ], "modifiers": [], "additional_components": [ "FBgn0262733", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P00528", "FBgn0262733" ] }, "reaction_10439330": { "compartment": "compartment_70101", "id": "reaction_10439330", "reactome": "R-DME-186780", "name": "PI3-kinase binds to the active receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439288", "species_10431820" ], "products": [ "species_10439328" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10446228": { "compartment": "compartment_984", "id": "reaction_10446228", "reactome": "R-DME-382057", "name": "Release of novel PDGFs as latent factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446216" ], "products": [ "species_10446226" ], "modifiers": [], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964" ] }, "reaction_10439347": { "compartment": "compartment_70101", "id": "reaction_10439347", "reactome": "R-DME-186786", "name": "Autophosphorylation of PDGF beta receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439342" ], "products": [ "species_10439344", "species_29370" ], "modifiers": [ [ "species_10439342", "catalyst" ] ], "additional_components": [ "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VJ04", "FBgn0032752", "E1JHB7", "FBgn0032006", "Q9VWP6", "FBgn0030964" ] }, "reaction_10489775": { "compartment": "compartment_984", "id": "reaction_10489775", "reactome": "R-DME-8865275", "name": "PDGF-BB clevage by Furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446190" ], "products": [ "species_10439282", "species_10489771" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9VWP6", "FBgn0030964", "Q9VWP6", "FBgn0030964", "FBgn0030964", "FBgn0004509" ] }, "reaction_10479727": { "compartment": "compartment_70101", "id": "reaction_10479727", "reactome": "R-DME-6785648", "name": "MEMO1 binds RHOA:GTP:DIAPH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479721", "species_10475516" ], "products": [ "species_10479725" ], "modifiers": [], "additional_components": [ "Q9VG04", "FBgn0038110", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "Q9VG04", "FBgn0038110", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10479723": { "compartment": "compartment_70101", "id": "reaction_10479723", "reactome": "R-DME-6785636", "name": "Phosphorylated ERBB2 heterodimers bind MEMO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458352", "species_10479719" ], "products": [ "species_10479721" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0038110", "Q9VG04", "FBgn0038110", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10498279": { "compartment": "compartment_70101", "id": "reaction_10498279", "reactome": "R-DME-9652264", "name": "ERBB2 binds TKIs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9652360", "species_10462124" ], "products": [ "species_10462235" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573" ] }, "reaction_10462237": { "compartment": "compartment_876", "id": "reaction_10462237", "reactome": "R-DME-1963582", "name": "Trans-autophosphorylation of ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462226", "species_113592" ], "products": [ "species_29370", "species_10458345" ], "modifiers": [ [ "species_10462226", "catalyst" ], [ "species_10462231", "inhibitor" ], [ "species_10462235", "inhibitor" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P04412", "FBgn0003731", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573" ] }, "reaction_10458911": { "compartment": "compartment_876", "id": "reaction_10458911", "reactome": "R-DME-1306957", "name": "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10458908", "catalyst" ] ], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10458913": { "compartment": "compartment_876", "id": "reaction_10458913", "reactome": "R-DME-1306963", "name": "Binding of GRB2:GAB1 to p-ERBB2:p-EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458352", "species_10438839" ], "products": [ "species_10458904" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10458920": { "compartment": "compartment_876", "id": "reaction_10458920", "reactome": "R-DME-1306972", "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10458917", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10462245": { "compartment": "compartment_876", "id": "reaction_10462245", "reactome": "R-DME-1963586", "name": "SRC family kinases phosphorylate ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462226", "species_113592" ], "products": [ "species_29370", "species_10462221" ], "modifiers": [ [ "species_10444503", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0262733" ] }, "reaction_10458359": { "compartment": "compartment_876", "id": "reaction_10458359", "reactome": "R-DME-1250195", "name": "SHC1 phosphorylation by ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458354", "species_113592" ], "products": [ "species_10458356", "species_29370" ], "modifiers": [ [ "species_10458354", "catalyst" ] ], "additional_components": [ "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10491995": { "compartment": "compartment_70101", "id": "reaction_10491995", "reactome": "R-DME-8934446", "name": "Activated PKC phosphorylates SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10476601" ], "products": [ "species_10491981", "species_29370" ], "modifiers": [ [ "species_10491992", "catalyst" ] ], "additional_components": [ "FBgn0015296", "FBgn0015296", "species_74016", "P05130", "FBgn0003091", "species_114519", "species_33625" ] }, "reaction_10489700": { "compartment": "compartment_876", "id": "reaction_10489700", "reactome": "R-DME-8864125", "name": "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10489685" ], "products": [ "species_29372", "species_10489697" ], "modifiers": [ [ "species_10489685", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10462217": { "compartment": "compartment_876", "id": "reaction_10462217", "reactome": "R-DME-1963563", "name": "MATK (CSK homologous kinase) binds phosphorylated ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458352", "species_10462213" ], "products": [ "species_10462215" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0262081", "Q8INJ8", "FBgn0262081", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10462134": { "compartment": "compartment_70101", "id": "reaction_10462134", "reactome": "R-DME-1918095", "name": "CUL5 mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10462124" ], "products": [ "species_10462131" ], "modifiers": [ [ "species_10456634", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "FBgn0039632" ] }, "reaction_10458958": { "compartment": "compartment_70101", "id": "reaction_10458958", "reactome": "R-DME-1358792", "name": "RNF41 ubiquitinates activated ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458953", "species_10426987" ], "products": [ "species_10458955", "species_10456701" ], "modifiers": [ [ "species_10458953", "catalyst" ] ], "additional_components": [ "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649", "Q9VUV7", "FBgn0283649" ] }, "reaction_10458939": { "compartment": "compartment_70101", "id": "reaction_10458939", "reactome": "R-DME-1358790", "name": "RNF41 ubiquitinates ERBB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458934", "species_10426987" ], "products": [ "species_10458936", "species_10456701" ], "modifiers": [ [ "species_10458934", "catalyst" ] ], "additional_components": [ "Q9VUV7", "FBgn0283649", "P04412", "FBgn0003731", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "FBgn0283649", "Q9VUV7", "FBgn0283649", "P04412", "FBgn0003731" ] }, "reaction_10458967": { "compartment": "compartment_70101", "id": "reaction_10458967", "reactome": "R-DME-1358801", "name": "ERBB3 binds RNF41 ubiquitin ligase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458281", "species_10456701" ], "products": [ "species_10458934" ], "modifiers": [], "additional_components": [ "FBgn0003731", "FBgn0283649", "Q9VUV7", "FBgn0283649", "P04412", "FBgn0003731" ] }, "reaction_10458949": { "compartment": "compartment_70101", "id": "reaction_10458949", "reactome": "R-DME-1358791", "name": "Phosphorylation of USP8 by P-AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458944", "species_113592" ], "products": [ "species_10458947", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0038862", "FBgn0038862" ] }, "reaction_10458965": { "compartment": "compartment_70101", "id": "reaction_10458965", "reactome": "R-DME-1358797", "name": "Ubiquitinated RNF41 binds P-USP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458929", "species_10458947" ], "products": [ "species_10458960" ], "modifiers": [], "additional_components": [ "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0038862", "Q9VDD8", "FBgn0038862", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10458932": { "compartment": "compartment_70101", "id": "reaction_10458932", "reactome": "R-DME-1358789", "name": "Self-ubiquitination of RNF41", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10456701" ], "products": [ "species_10458929" ], "modifiers": [ [ "species_10456701", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649" ] }, "reaction_10458963": { "compartment": "compartment_70101", "id": "reaction_10458963", "reactome": "R-DME-1358795", "name": "Deubiquitination of RNF41 by P-USP8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458960" ], "products": [ "species_10458947", "species_10426987", "species_10456701" ], "modifiers": [ [ "species_10458960", "catalyst" ] ], "additional_components": [ "Q9VDD8", "FBgn0038862", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0038862", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0283649", "Q9VDD8", "FBgn0038862", "Q9VUV7", "FBgn0283649", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10462129": { "compartment": "compartment_70101", "id": "reaction_10462129", "reactome": "R-DME-1918092", "name": "CHIP (STUB1) mediates ubiquitination of ERBB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10462124" ], "products": [ "species_10462126" ], "modifiers": [ [ "species_10456460", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "FBgn0027052" ] }, "reaction_10462224": { "compartment": "compartment_876", "id": "reaction_10462224", "reactome": "R-DME-1963581", "name": "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10462221" ], "products": [ "species_29370", "species_10458350" ], "modifiers": [ [ "species_10462221", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10498464": { "compartment": "compartment_459", "id": "reaction_10498464", "reactome": "R-DME-9674531", "name": "AAMP binds EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498460", "species_10438846" ], "products": [ "species_10498462" ], "modifiers": [], "additional_components": [ "FBgn0036460", "FBgn0003731", "P04412", "FBgn0003731", "M9NE98", "FBgn0036460" ] }, "reaction_10438959": { "compartment": "compartment_70101", "id": "reaction_10438959", "reactome": "R-DME-177934", "name": "EGFR autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10438855" ], "products": [ "species_29370", "species_10438908" ], "modifiers": [ [ "species_10438855", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10439003": { "compartment": "compartment_984", "id": "reaction_10439003", "reactome": "R-DME-177942", "name": "EGFR binds EGF ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438851", "species_10438846" ], "products": [ "species_10438853" ], "modifiers": [ [ "species_10439001", "inhibitor" ] ], "additional_components": [ "FBgn0000119", "FBgn0003731", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0034083" ] }, "reaction_10438857": { "compartment": "compartment_876", "id": "reaction_10438857", "reactome": "R-DME-177922", "name": "EGFR dimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438853" ], "products": [ "species_10438855" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10443325": { "compartment": "compartment_876", "id": "reaction_10443325", "reactome": "R-DME-212713", "name": "Active PLC-gamma1 dissociates from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443320" ], "products": [ "species_10441915", "species_10438908" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VXH3", "FBgn0003416", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10443323": { "compartment": "compartment_70101", "id": "reaction_10443323", "reactome": "R-DME-212710", "name": "EGFR activates PLC-gamma1 by phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443316", "species_113592" ], "products": [ "species_29370", "species_10443320" ], "modifiers": [ [ "species_10443316", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VXH3", "FBgn0003416", "Q9VXH3", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10443318": { "compartment": "compartment_876", "id": "reaction_10443318", "reactome": "R-DME-212706", "name": "Phospholipase C-gamma1 binds to the activated EGF receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438908", "species_10441886" ], "products": [ "species_10443316" ], "modifiers": [], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0003416", "Q9VXH3", "FBgn0003416", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10438943": { "compartment": "compartment_70101", "id": "reaction_10438943", "reactome": "R-DME-177930", "name": "GAB1 phosphorylation by EGFR kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10438937" ], "products": [ "species_29370", "species_10438910" ], "modifiers": [ [ "species_10438937", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438927": { "compartment": "compartment_70101", "id": "reaction_10438927", "reactome": "R-DME-177924", "name": "Dephosphorylation of Gab1 by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438912", "species_29356" ], "products": [ "species_29372", "species_10438925" ], "modifiers": [ [ "species_10438912", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438841": { "compartment": "compartment_70101", "id": "reaction_10438841", "reactome": "R-DME-177920", "name": "Binding of GRB2 to GAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433424", "species_10431791" ], "products": [ "species_10438839" ], "modifiers": [], "additional_components": [ "FBgn0016794", "FBgn0004638", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794" ] }, "reaction_10438969": { "compartment": "compartment_70101", "id": "reaction_10438969", "reactome": "R-DME-177935", "name": "SHP2 dephosphorylates Tyr 992 on EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438912", "species_29356" ], "products": [ "species_29372", "species_10438967" ], "modifiers": [ [ "species_10438912", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438996": { "compartment": "compartment_70101", "id": "reaction_10438996", "reactome": "R-DME-177941", "name": "GRB2:GAB1 binds to phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438935", "species_10438908" ], "products": [ "species_10438937" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10439027": { "compartment": "compartment_70101", "id": "reaction_10439027", "reactome": "R-DME-179467", "name": "GAB1 binds phosphatidylinositol-3,4,5-trisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10438839" ], "products": [ "species_10438933" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438915": { "compartment": "compartment_70101", "id": "reaction_10438915", "reactome": "R-DME-177923", "name": "Sustained activation of SRC kinase by SHP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10438877" ], "products": [ "species_29372", "species_10438883", "species_10438862" ], "modifiers": [ [ "species_10438912", "catalyst" ] ], "additional_components": [ "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q2PDT4", "FBgn0041789", "Q2PDT4", "FBgn0041789", "P00528", "FBgn0262733", "FBgn0262081", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838" ] }, "reaction_10438994": { "compartment": "compartment_70101", "id": "reaction_10438994", "reactome": "R-DME-177939", "name": "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10438991", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "species_179838", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10439199": { "compartment": "compartment_70101", "id": "reaction_10439199", "reactome": "R-DME-183089", "name": "CBL binds and ubiquitinates phosphorylated Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439111", "species_10426987", "species_10439039" ], "products": [ "species_10439174" ], "modifiers": [ [ "species_10439039", "catalyst" ] ], "additional_components": [ "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10439103": { "compartment": "compartment_70101", "id": "reaction_10439103", "reactome": "R-DME-182986", "name": "CBL-mediated ubiquitination of CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439090", "species_10426987" ], "products": [ "species_10439100" ], "modifiers": [ [ "species_10439090", "catalyst" ] ], "additional_components": [ "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q8T390", "FBgn0038659", "Q9VS85", "FBgn0028582", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659" ] }, "reaction_10439197": { "compartment": "compartment_70101", "id": "reaction_10439197", "reactome": "R-DME-183084", "name": "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439192", "species_10426987" ], "products": [ "species_10439185", "species_10439194" ], "modifiers": [ [ "species_10439192", "catalyst" ] ], "additional_components": [ "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10439164": { "compartment": "compartment_70101", "id": "reaction_10439164", "reactome": "R-DME-183036", "name": "Ubiquitination of stimulated EGFR (CBL:GRB2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10439132" ], "products": [ "species_10439156" ], "modifiers": [ [ "species_10439132", "catalyst" ], [ "species_10439162", "inhibitor" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "FBgn0267486" ] }, "reaction_10439130": { "compartment": "compartment_70101", "id": "reaction_10439130", "reactome": "R-DME-182993", "name": "Ubiquitination of stimulated EGFR (CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10439039" ], "products": [ "species_10439127" ], "modifiers": [ [ "species_10439039", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119" ] }, "reaction_10439190": { "compartment": "compartment_70101", "id": "reaction_10439190", "reactome": "R-DME-183067", "name": "Localization of CBL:GRB2 to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439179", "species_10438908" ], "products": [ "species_10439185" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439125": { "compartment": "compartment_876", "id": "reaction_10439125", "reactome": "R-DME-182990", "name": "Sprouty sequesters CBL away from active EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439090", "species_10439119" ], "products": [ "species_10439123" ], "modifiers": [], "additional_components": [ "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659", "FBgn0014388", "O44783", "FBgn0014388", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "Q8T390", "FBgn0038659" ] }, "reaction_10439188": { "compartment": "compartment_70101", "id": "reaction_10439188", "reactome": "R-DME-183058", "name": "Phosphorylation of CBL (EGFR:GRB2:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439185", "species_113592" ], "products": [ "species_29370", "species_10439132" ], "modifiers": [ [ "species_10439185", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439152": { "compartment": "compartment_70101", "id": "reaction_10439152", "reactome": "R-DME-183002", "name": "Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439146", "species_10439148" ], "products": [ "species_10439150" ], "modifiers": [], "additional_components": [ "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10439183": { "compartment": "compartment_876", "id": "reaction_10439183", "reactome": "R-DME-183055", "name": "Binding of CBL to EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10438908" ], "products": [ "species_10439034" ], "modifiers": [], "additional_components": [ "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224" ] }, "reaction_10490064": { "compartment": "compartment_876", "id": "reaction_10490064", "reactome": "R-DME-8867041", "name": "EGFR phosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490059", "species_113592" ], "products": [ "species_10490061", "species_29370" ], "modifiers": [ [ "species_10490059", "catalyst" ] ], "additional_components": [ "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582" ] }, "reaction_10439181": { "compartment": "compartment_70101", "id": "reaction_10439181", "reactome": "R-DME-183052", "name": "CBL binds to GRB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10431791" ], "products": [ "species_10439179" ], "modifiers": [], "additional_components": [ "FBgn0020224", "FBgn0004638", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439117": { "compartment": "compartment_876", "id": "reaction_10439117", "reactome": "R-DME-182988", "name": "Sprouty lures CBL away from EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439109", "species_10439032" ], "products": [ "species_10439115" ], "modifiers": [], "additional_components": [ "FBgn0014388", "FBgn0020224", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388" ] }, "reaction_10490066": { "compartment": "compartment_876", "id": "reaction_10490066", "reactome": "R-DME-8867044", "name": "EGFR binds EPS15, EPN1, EPS15L1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439047", "species_10439066", "species_10439068", "species_10439148", "species_179856" ], "products": [ "species_10490059" ], "modifiers": [], "additional_components": [ "FBgn0028582", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582" ] }, "reaction_10439177": { "compartment": "compartment_70101", "id": "reaction_10439177", "reactome": "R-DME-183051", "name": "CBL ubiquitinates Sprouty", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439170", "species_10426987" ], "products": [ "species_10439174" ], "modifiers": [ [ "species_10439170", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O44783", "FBgn0014388", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "O44783", "FBgn0014388" ] }, "reaction_10490074": { "compartment": "compartment_876", "id": "reaction_10490074", "reactome": "R-DME-8867047", "name": "PTPN3 dephosphorylates EPS15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490061", "species_29356" ], "products": [ "species_29372", "species_10490059" ], "modifiers": [ [ "species_10490071", "catalyst" ] ], "additional_components": [ "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "species_179856", "Q9W111", "FBgn0035060", "Q08012", "FBgn0004638", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VS85", "FBgn0028582", "FBgn0261985" ] }, "reaction_10439203": { "compartment": "compartment_70101", "id": "reaction_10439203", "reactome": "R-DME-183094", "name": "CDC42:GTP binds CBL:Beta-Pix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439032", "species_10439146" ], "products": [ "species_10439201" ], "modifiers": [], "additional_components": [ "FBgn0020224", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "Q9VSK2", "FBgn0020224" ] }, "reaction_10439042": { "compartment": "compartment_70101", "id": "reaction_10439042", "reactome": "R-DME-182969", "name": "Phosphorylation of CBL (EGFR:CBL)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439034" ], "products": [ "species_29370", "species_10439039" ], "modifiers": [ [ "species_10439034", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224", "Q9VSK2", "FBgn0020224", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VSK2", "FBgn0020224" ] }, "reaction_10438973": { "compartment": "compartment_70101", "id": "reaction_10438973", "reactome": "R-DME-177936", "name": "GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10438953" ], "products": [ "species_10438971" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10438956": { "compartment": "compartment_70101", "id": "reaction_10438956", "reactome": "R-DME-177933", "name": "SHC1 phosphorylation by phosphorylated EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438929", "species_113592" ], "products": [ "species_29370", "species_10438953" ], "modifiers": [ [ "species_10438929", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296" ] }, "reaction_10438931": { "compartment": "compartment_70101", "id": "reaction_10438931", "reactome": "R-DME-177925", "name": "SHC1 binds to the phosphorylated EGF receptor:ligand complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431840", "species_10438908" ], "products": [ "species_10438929" ], "modifiers": [], "additional_components": [ "FBgn0015296", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296" ] }, "reaction_10439009": { "compartment": "compartment_70101", "id": "reaction_10439009", "reactome": "R-DME-177945", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10438971", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10438978": { "compartment": "compartment_70101", "id": "reaction_10438978", "reactome": "R-DME-177937", "name": "Phosphorylation of EGFR by SRC kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10438855" ], "products": [ "species_29370", "species_10438908" ], "modifiers": [ [ "species_10438975", "catalyst" ] ], "additional_components": [ "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "FBgn0262733" ] }, "reaction_10439006": { "compartment": "compartment_70101", "id": "reaction_10439006", "reactome": "R-DME-177943", "name": "GRB2:SOS1 complex binds to EGF:EGFR complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10438908" ], "products": [ "species_10438982" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10438985": { "compartment": "compartment_70101", "id": "reaction_10438985", "reactome": "R-DME-177938", "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10438982", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10486291": { "compartment": "compartment_7660", "id": "reaction_10486291", "reactome": "R-DME-6807118", "name": "USP7 deubiquitinates monoubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10486280" ], "products": [ "species_10427430", "species_10486289" ], "modifiers": [ [ "species_10467616", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0030366" ] }, "reaction_10486293": { "compartment": "compartment_7660", "id": "reaction_10486293", "reactome": "R-DME-6807126", "name": "Deubiquitinated PTEN translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486289" ], "products": [ "species_10441147" ], "modifiers": [], "additional_components": [] }, "reaction_10486282": { "compartment": "compartment_70101", "id": "reaction_10486282", "reactome": "R-DME-6807105", "name": "Monoubiquitinated PTEN translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486276" ], "products": [ "species_10486280" ], "modifiers": [], "additional_components": [] }, "reaction_10486287": { "compartment": "compartment_70101", "id": "reaction_10486287", "reactome": "R-DME-6807106", "name": "PTEN undergoes monoubiquitination", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10441147" ], "products": [ "species_10486276" ], "modifiers": [ [ "species_10486284", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10433277": { "compartment": "compartment_7660", "id": "reaction_10433277", "reactome": "R-DME-77589", "name": "Recognition of AAUAAA sequence by CPSF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433273", "species_10429982" ], "products": [ "species_10433275" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10433287": { "compartment": "compartment_7660", "id": "reaction_10433287", "reactome": "R-DME-77592", "name": "Cleavage of Intronless Pre-mRNA at 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433283" ], "products": [ "species_10430001", "species_10430036", "species_10433285", "species_10430024", "species_112165" ], "modifiers": [], "additional_components": [ "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7KNF2", "FBgn0005648", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q7K4N3", "FBgn0022942", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q9V3L6", "FBgn0022943", "Q7KNF2", "FBgn0005648", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872" ] }, "reaction_10433281": { "compartment": "compartment_7660", "id": "reaction_10433281", "reactome": "R-DME-77590", "name": "Recruitment of CstF to the CPSF Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430001", "species_10433275" ], "products": [ "species_10433279" ], "modifiers": [], "additional_components": [ "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867" ] }, "reaction_10461644": { "compartment": "compartment_17957", "id": "reaction_10461644", "reactome": "R-DME-1855200", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024002" ], "products": [ "species_113551", "species_2024016" ], "modifiers": [ [ "species_10461541", "catalyst" ] ], "additional_components": [ "FBgn0026061" ] }, "reaction_10461544": { "compartment": "compartment_17957", "id": "reaction_10461544", "reactome": "R-DME-1855163", "name": "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024008" ], "products": [ "species_113551", "species_2024012" ], "modifiers": [ [ "species_10461541", "catalyst" ] ], "additional_components": [ "FBgn0026061" ] }, "reaction_10461732": { "compartment": "compartment_17957", "id": "reaction_10461732", "reactome": "R-DME-1855225", "name": "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_2024018" ], "products": [ "species_113551", "species_2564836" ], "modifiers": [ [ "species_10461541", "catalyst" ] ], "additional_components": [ "FBgn0026061" ] }, "reaction_10473766": { "compartment": "compartment_876", "id": "reaction_10473766", "reactome": "R-DME-5623632", "name": "RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473760", "species_10433704" ], "products": [ "species_10473764" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621", "Q9W0V1", "Pdk1", "species_179838", "Q9W0V1", "Pdk1", "species_179838", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621" ] }, "reaction_10475670": { "compartment": "compartment_70101", "id": "reaction_10475670", "reactome": "R-DME-5671749", "name": "p-T774-PKN1 phosphorylates CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475665", "species_113592" ], "products": [ "species_10431988", "species_29370", "species_10473769" ], "modifiers": [ [ "species_10475665", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "A1Z7T0", "FBgn0020621", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0020621", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "A1Z7T0", "FBgn0020621" ] }, "reaction_10432022": { "compartment": "compartment_70101", "id": "reaction_10432022", "reactome": "R-DME-75016", "name": "Association of p-S216-CDC25C with 14-3-3 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432018", "species_10431988" ], "products": [ "species_10432020" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon" ] }, "reaction_10475685": { "compartment": "compartment_70101", "id": "reaction_10475685", "reactome": "R-DME-5671772", "name": "p-T38-PPP1R14A binds MLCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475630", "species_10475678" ], "products": [ "species_10475683" ], "modifiers": [], "additional_components": [ "M9NEB2", "FBgn0005536", "P48462", "flw", "FBgn0032297", "Q9VKQ5", "FBgn0032297", "M9NEB2", "FBgn0005536", "P48462", "flw" ] }, "reaction_10475667": { "compartment": "compartment_70101", "id": "reaction_10475667", "reactome": "R-DME-5671737", "name": "p-T774-PKN1 binds CDC25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473769", "species_10435503" ], "products": [ "species_10475665" ], "modifiers": [], "additional_components": [ "FBgn0020621", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "A1Z7T0", "FBgn0020621" ] }, "reaction_10473762": { "compartment": "compartment_876", "id": "reaction_10473762", "reactome": "R-DME-5623622", "name": "RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473750", "species_10473758" ], "products": [ "species_10473760" ], "modifiers": [], "additional_components": [ "FBgn0020621", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621" ] }, "reaction_10473778": { "compartment": "compartment_70101", "id": "reaction_10473778", "reactome": "R-DME-5623667", "name": "PDPK1 phosphorylates PKN1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473764", "species_113592" ], "products": [ "species_29370", "species_10433704", "species_10473769", "species_10473758" ], "modifiers": [ [ "species_10473764", "catalyst" ] ], "additional_components": [ "Q9W0V1", "Pdk1", "species_179838", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621", "Q9W0V1", "Pdk1", "species_179838", "FBgn0020621", "P48148", "Rho1", "species_29438", "Q9W0V1", "Pdk1", "species_179838", "P48148", "Rho1", "species_29438", "A1Z7T0", "FBgn0020621" ] }, "reaction_10474173": { "compartment": "compartment_7660", "id": "reaction_10474173", "reactome": "R-DME-5625717", "name": "Phosphorylated PKN1 binds androgen receptor (AR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473330", "species_10473769" ], "products": [ "species_10474171" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849", "FBgn0020621", "A1Z7T0", "FBgn0020621", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849" ] }, "reaction_10474183": { "compartment": "compartment_7660", "id": "reaction_10474183", "reactome": "R-DME-5625745", "name": "PKN1 stimulates association of AR with NCOA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474177", "species_10440442" ], "products": [ "species_10474181" ], "modifiers": [], "additional_components": [ "A1Z7T0", "FBgn0020621", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "FBgn0041092", "A1Z7T0", "FBgn0020621", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "M9ND53", "FBgn0041092" ] }, "reaction_10474179": { "compartment": "compartment_70101", "id": "reaction_10474179", "reactome": "R-DME-5625738", "name": "p-T774-PKN1:AR:Androgen complex translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474171" ], "products": [ "species_10474177" ], "modifiers": [], "additional_components": [ "A1Z7T0", "FBgn0020621", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849", "A1Z7T0", "FBgn0020621", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079" ] }, "reaction_10475681": { "compartment": "compartment_70101", "id": "reaction_10475681", "reactome": "R-DME-5671763", "name": "p-T774-PKN1 phosphorylates PPP1R14A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475675" ], "products": [ "species_29370", "species_10475678" ], "modifiers": [ [ "species_10473769", "catalyst" ] ], "additional_components": [ "FBgn0032297", "FBgn0032297", "FBgn0020621" ] }, "reaction_10475533": { "compartment": "compartment_70101", "id": "reaction_10475533", "reactome": "R-DME-5665999", "name": "MKL1 translocates from cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475531" ], "products": [ "species_10469150" ], "modifiers": [], "additional_components": [ "FBgn0052296", "FBgn0052296" ] }, "reaction_10469116": { "compartment": "compartment_70101", "id": "reaction_10469116", "reactome": "R-DME-3858495", "name": "DAAM1 recruits GTP-bound RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469108", "species_10469112" ], "products": [ "species_10469114" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "M9MSM5", "FBgn0025641", "species_29926", "P48148", "Rho1", "species_29438", "species_29926", "P48148", "Rho1", "species_29438", "P51140", "phospho-dsh", "M9MSM5", "FBgn0025641" ] }, "reaction_10475529": { "compartment": "compartment_7660", "id": "reaction_10475529", "reactome": "R-DME-5665998", "name": "MKL1 binds SRF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475525", "species_10469150" ], "products": [ "species_10475527" ], "modifiers": [], "additional_components": [ "FBgn0004101", "FBgn0052296", "B7Z043", "FBgn0052296", "Q24535", "FBgn0004101" ] }, "reaction_10475542": { "compartment": "compartment_7660", "id": "reaction_10475542", "reactome": "R-DME-5666008", "name": "SCAI binds SRF:MKL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475538", "species_10475527" ], "products": [ "species_10475540" ], "modifiers": [], "additional_components": [ "FBgn0035677", "B7Z043", "FBgn0052296", "Q24535", "FBgn0004101", "B7Z043", "FBgn0052296", "Q24535", "FBgn0004101", "M9PER3", "FBgn0035677" ] }, "reaction_10475558": { "compartment": "compartment_70101", "id": "reaction_10475558", "reactome": "R-DME-5666104", "name": "RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475552", "species_10440003" ], "products": [ "species_10475556" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202", "FBgn0262733", "P00528", "FBgn0262733", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202" ] }, "reaction_10469110": { "compartment": "compartment_70101", "id": "reaction_10469110", "reactome": "R-DME-3858489", "name": "ppDVL binds DAAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469106", "species_10441719" ], "products": [ "species_10469108" ], "modifiers": [], "additional_components": [ "FBgn0025641", "P51140", "phospho-dsh", "M9MSM5", "FBgn0025641" ] }, "reaction_10475554": { "compartment": "compartment_70101", "id": "reaction_10475554", "reactome": "R-DME-5666088", "name": "RHOD:GTP recruits DAIPH2-3 to endosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475546", "species_10475550" ], "products": [ "species_10475552" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202" ] }, "reaction_10475457": { "compartment": "compartment_876", "id": "reaction_10475457", "reactome": "R-DME-5665727", "name": "FMNL2 binds CDC42:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439139", "species_10475453" ], "products": [ "species_10475455" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "Q9VUC6", "FBgn0267795", "M9PE53", "FBgn0264272", "Q9VUC6", "FBgn0267795", "M9PE53", "FBgn0264272", "species_29438", "P40793", "FBgn0010341" ] }, "reaction_10475520": { "compartment": "compartment_70101", "id": "reaction_10475520", "reactome": "R-DME-5665989", "name": "DIAPH1 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475514", "species_10434906" ], "products": [ "species_10475516" ], "modifiers": [], "additional_components": [ "P48608", "FBgn0011202", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29438", "P48608", "FBgn0011202" ] }, "reaction_10464334": { "compartment": "compartment_70101", "id": "reaction_10464334", "reactome": "R-DME-2029460", "name": "PAK1 phosphorylates LIMK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10447163" ], "products": [ "species_29370", "species_10447166" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "FBgn0283712", "FBgn0283712", "FBgn0267698" ] }, "reaction_10495682": { "compartment": "compartment_70101", "id": "reaction_10495682", "reactome": "R-DME-8981926", "name": "RAC1 and CDC42 activate PAK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446521", "species_10446509" ], "products": [ "species_10474308", "species_10446519" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "FBgn0267698" ] }, "reaction_10495684": { "compartment": "compartment_70101", "id": "reaction_10495684", "reactome": "R-DME-8981931", "name": "RAC1 and CDC42 activate PAK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446517", "species_10446509" ], "products": [ "species_10474306", "species_10446515" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "FBgn0267698" ] }, "reaction_10475643": { "compartment": "compartment_70101", "id": "reaction_10475643", "reactome": "R-DME-5669158", "name": "NF2 binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_10464328" ], "products": [ "species_10475641" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "FBgn0086384", "Q24564", "FBgn0086384", "B7Z0W0", "FBgn0267698" ] }, "reaction_10464330": { "compartment": "compartment_70101", "id": "reaction_10464330", "reactome": "R-DME-2029456", "name": "RAC1 and CDC42 activate PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446513", "species_10446509" ], "products": [ "species_10446525", "species_10446511" ], "modifiers": [ [ "species_10464328", "inhibitor" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698", "FBgn0086384" ] }, "reaction_10474313": { "compartment": "compartment_70101", "id": "reaction_10474313", "reactome": "R-DME-5627775", "name": "Autophosphorylation of PAK1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10474310" ], "products": [ "species_29370", "species_10447061", "species_10446509" ], "modifiers": [ [ "species_10474310", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME" ] }, "reaction_10475657": { "compartment": "compartment_70101", "id": "reaction_10475657", "reactome": "R-DME-5669250", "name": "PAK1 phosphorylates FLNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475647" ], "products": [ "species_10447061", "species_29370", "species_10475654" ], "modifiers": [ [ "species_10475647", "catalyst" ] ], "additional_components": [ "Q9VEN1", "FBgn0014141", "B7Z0W0", "FBgn0267698", "FBgn0267698", "Q9VEN1", "FBgn0014141", "Q9VEN1", "FBgn0014141", "B7Z0W0", "FBgn0267698" ] }, "reaction_10475622": { "compartment": "compartment_70101", "id": "reaction_10475622", "reactome": "R-DME-5668932", "name": "PAK2 phosphorylates myosin regulatory light chain (MRLC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475599" ], "products": [ "species_10475619", "species_29370" ], "modifiers": [ [ "species_10447065", "catalyst" ] ], "additional_components": [ "Q9VG88", "FBgn0053098", "P40423", "phospho-sqh", "P18432", "FBgn0002773", "Q9W4B1", "FBgn0085464", "Q9VQA5", "FBgn0031410", "P54357", "Mlc-c", "P06742", "FBgn0002772", "Q99323", "zip", "Q9W4B1", "FBgn0085464", "Q9VQA5", "FBgn0031410", "P54357", "Mlc-c", "P06742", "FBgn0002772", "Q99323", "zip", "Q9VG88", "FBgn0053098", "P40423", "phospho-sqh", "P18432", "FBgn0002773", "FBgn0267698" ] }, "reaction_10475637": { "compartment": "compartment_70101", "id": "reaction_10475637", "reactome": "R-DME-5668947", "name": "PAK1 phosphorylates myosin phosphatase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475630" ], "products": [ "species_10475635", "species_29370" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "M9NEB2", "FBgn0005536", "P48462", "flw", "M9NEB2", "FBgn0005536", "P48462", "flw", "FBgn0267698" ] }, "reaction_10475649": { "compartment": "compartment_70101", "id": "reaction_10475649", "reactome": "R-DME-5669240", "name": "FLNA binds PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447061", "species_10475645" ], "products": [ "species_10475647" ], "modifiers": [], "additional_components": [ "FBgn0267698", "Q9VEN1", "FBgn0014141", "Q9VEN1", "FBgn0014141", "B7Z0W0", "FBgn0267698" ] }, "reaction_10481326": { "compartment": "compartment_1222693", "id": "reaction_10481326", "reactome": "R-DME-6798174", "name": "PIK3C3:PIK3R4 phosphorylates PI to PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524165" ], "products": [ "species_1629751", "species_29370" ], "modifiers": [ [ "species_10481323", "catalyst" ] ], "additional_components": [ "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10464910": { "compartment": "compartment_876", "id": "reaction_10464910", "reactome": "R-DME-2130194", "name": "ABL phosphorylates WAVEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464388", "species_113592" ], "products": [ "species_10464452", "species_29370" ], "modifiers": [ [ "species_10445197", "catalyst" ] ], "additional_components": [ "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "Q9VE13", "FBgn0026239", "F2FB81", "FBgn0041781", "P55162", "FBgn0011771", "P40792", "RAC1_DROME", "species_29438", "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10464460": { "compartment": "compartment_70101", "id": "reaction_10464460", "reactome": "R-DME-2029466", "name": "(WASPs, WAVE):G-actin:ARP2/3 binds F-actin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449184", "species_10464456" ], "products": [ "species_10464458" ], "modifiers": [], "additional_components": [ "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438" ] }, "reaction_10464473": { "compartment": "compartment_70101", "id": "reaction_10464473", "reactome": "R-DME-2029469", "name": "p-ERK phosphorylates WAVEs and ABI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464452", "species_113592" ], "products": [ "species_29370", "species_10464428" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "Q8IQE6", "FBgn0052082", "species_179838", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "P40417", "FBgn0003256" ] }, "reaction_10465367": { "compartment": "compartment_70101", "id": "reaction_10465367", "reactome": "R-DME-2197690", "name": "Detachment of WASP/WAVE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464458" ], "products": [ "species_10464454", "species_10464494" ], "modifiers": [], "additional_components": [ "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9VF87", "FBgn0038320", "Q8MLQ0", "FBgn0061198", "P55162", "FBgn0011771", "F2FB81", "FBgn0041781", "Q9VE13", "FBgn0026239", "Q8IQE6", "FBgn0052082", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_29370" ] }, "reaction_10464496": { "compartment": "compartment_70101", "id": "reaction_10464496", "reactome": "R-DME-2029473", "name": "Branching and elongation of mother and daughter filaments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464494", "species_10442127" ], "products": [ "species_10461792" ], "modifiers": [], "additional_components": [ "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_29370", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "O97182", "FBgn0001961", "P45888", "FBgn0011742", "species_113592", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046" ] }, "reaction_10475571": { "compartment": "compartment_70101", "id": "reaction_10475571", "reactome": "R-DME-5667008", "name": "RHOA:GTP binds RHPN1 or RHPN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434906", "species_10475565" ], "products": [ "species_10475569" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "FBgn0026374", "Q9XYY9", "FBgn0026374", "P48148", "Rho1", "species_29438" ] }, "reaction_10438409": { "compartment": "compartment_12045", "id": "reaction_10438409", "reactome": "R-DME-174368", "name": "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158601", "species_162756" ], "products": [ "species_3499326", "species_174384" ], "modifiers": [ [ "species_10438406", "catalyst" ] ], "additional_components": [ "Q95YI5", "FBgn0042641" ] }, "reaction_10427874": { "compartment": "compartment_70101", "id": "reaction_10427874", "reactome": "R-DME-70286", "name": "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548", "species_29494" ], "products": [ "species_111294", "species_29410" ], "modifiers": [ [ "species_10427871", "catalyst" ] ], "additional_components": [ "Q9VSW1", "FBgn0035978" ] }, "reaction_10437986": { "compartment": "compartment_70101", "id": "reaction_10437986", "reactome": "R-DME-173597", "name": "UDP-glucose is oxidised to UDP-glucuronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410", "species_29360" ], "products": [ "species_70106", "species_158601", "species_73473" ], "modifiers": [ [ "species_10437983", "catalyst" ] ], "additional_components": [ "O02373", "FBgn0261445" ] }, "reaction_10430076": { "compartment": "compartment_7660", "id": "reaction_10430076", "reactome": "R-DME-72139", "name": "Formation of the active Spliceosomal C (B*) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429728", "species_10429536", "species_10429650", "species_10429733", "species_10429638", "species_10429655", "species_10429704", "species_10429640", "species_10429721", "species_10429723", "species_10429660", "species_10429645" ], "products": [ "species_10429735", "species_10429529" ], "modifiers": [], "additional_components": [ "FBgn0086707", "Q9VQK5", "FBgn0031492", "Q9VHC7", "FBgn0267790", "Q27294", "FBgn0285954", "Q9VEJ1", "FBgn0025571", "P24785", "FBgn0002774", "A1ZBW0", "FBgn0267791", "Q9VU43", "FBgn0036340", "Q9V3V0", "FBgn0028554", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "Q9V3W7", "FBgn0283477", "Q9V9K7", "FBgn0033062", "P19018", "FBgn0003742", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"compartment": "compartment_7660", "id": "reaction_10435479", "reactome": "R-DME-156661", "name": "Formation of Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430113", "species_10430097" ], "products": [ "species_10430117" ], "modifiers": [], "additional_components": [ "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "P26686", "FBgn0004587", "Q9VHC7", "FBgn0267790", "Q08473", "FBgn0263396", "A1ZBW0", "FBgn0267791", "Q7KU81", "FBgn0259935", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "P19018", "FBgn0003742", "Q8MZI3", "FBgn0035720", "M9NEH9", "FBgn0262737", "E1JGL8", "FBgn0050122", "Q9W0Q2", "FBgn0035141", "Q9V3T8", "FBgn0265298", "Q02427", "FBgn0260944", "Q9VHC0", "FBgn0037707", "Q95RI7", "FBgn0039977", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VEP9", "FBgn0266917", "O46106", "FBgn0014366", "Q9VU15", "FBgn0036314", "Q7PL83", "FBgn0086683", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", 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event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430081", "species_10430083", "species_10430088", "species_10430073", "species_10430093" ], "products": [ "species_10430097" ], "modifiers": [], "additional_components": [ "FBgn0034923", "FBgn0003742", "FBgn0033556", "Q9VES0", "FBgn0038454", "Q24562", "FBgn0005411", "Q9VQF5", "FBgn0031452", "Q94535", "FBgn0017457", "P26686", "FBgn0004587", "Q9VHC7", "FBgn0267790", "Q08473", "FBgn0263396", "A1ZBW0", "FBgn0267791", "Q7KU81", "FBgn0259935", "Q9W0D6", "FBgn0035235", "Q9VGH5", "FBgn0259139", "P19018", "FBgn0003742", "Q8MZI3", "FBgn0035720", "M9NEH9", "FBgn0262737", "E1JGL8", "FBgn0050122", "Q9W0Q2", "FBgn0035141", "Q9V3T8", "FBgn0265298", "Q02427", "FBgn0260944", "Q9VHC0", "FBgn0037707", "Q95RI7", "FBgn0039977", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VEP9", "FBgn0266917", "O46106", 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"Q9VAY6", "FBgn0039558", "Q9V3B6", "FBgn0040235", "Q9VF55", "FBgn0038345", "Q9V3W7", "FBgn0283477", "Q960Q8", "FBgn0035027", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "P24785", "FBgn0002774", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q27294", "FBgn0285954", "Q94535", "FBgn0017457", "Q9VQF5", "FBgn0031452", "Q24562", "FBgn0005411", "Q9VES0", "FBgn0038454", "Q9VIZ3", "FBgn0086444" ] }, "reaction_10479004": { "compartment": "compartment_876", "id": "reaction_10479004", "reactome": "R-DME-5694462", "name": "ABHD6,12 hydrolyse 3AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694509" ], "products": [ "species_422506", "species_70106", "species_76116" ], "modifiers": [ [ "species_10479001", "catalyst" ] ], "additional_components": [ "FBgn0034419" ] }, "reaction_10448215": { "compartment": "compartment_876", "id": "reaction_10448215", "reactome": "R-DME-426032", "name": "DAG is metabolized by DAGL to 2-AG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114519" ], "products": [ "species_426026", "species_426030" ], "modifiers": [ [ "species_10448212", "catalyst" ] ], "additional_components": [ "FBgn0261244" ] }, "reaction_10478699": { "compartment": "compartment_20699", "id": "reaction_10478699", "reactome": "R-DME-5694418", "name": "RAB1:GTP binds USO1 and GORASP1:GOLGA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478691", "species_10478647", "species_10478684" ], "products": [ "species_10478697" ], "modifiers": [], "additional_components": [ "Q9W3N6", "FBgn0040087", "O18332", "FBgn0285937", "species_29438", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "Q9W3N6", "FBgn0040087", "O18332", "FBgn0285937", "species_29438", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855" ] }, "reaction_10478650": { "compartment": "compartment_13959", "id": "reaction_10478650", "reactome": "R-DME-5694409", "name": "Nucleotide exchange on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10478643" ], "products": [ "species_29420", "species_10478647" ], "modifiers": [ [ "species_10478643", "catalyst" ] ], "additional_components": [ "species_29420", "O18332", "FBgn0285937", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855", "O18332", "FBgn0285937", "species_29438", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855", "species_29420", "O18332", "FBgn0285937", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VLI9", "FBgn0260861", "Q9VFB7", "FBgn0038303", "Q9VSY8", "FBgn0260859", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "A1Z8I0", "FBgn0033605", "Q7K2Q8", "FBgn0266723", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "A1Z813", "FBgn0033460", "M9PC99", "FBgn0262126", "Q9V3J4", "FBgn0024509", "Q9VLS7", "FBgn0031990", "M9PGI6", "FBgn0260855" ] }, "reaction_10487625": { "compartment": "compartment_6791047", "id": "reaction_10487625", "reactome": "R-DME-6814831", "name": "TBC1D20 binds RAB1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487621", "species_10486338" ], "products": [ "species_10487623" ], "modifiers": [], "additional_components": [ "FBgn0040005", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W5H8", "FBgn0040005" ] }, "reaction_10478773": { "compartment": "compartment_6791047", "id": "reaction_10478773", "reactome": "R-DME-5694425", "name": "NSF ATPase activity dissociates cis-SNARE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478768", "species_113592" ], "products": [ "species_10478736", "species_29372", "species_10478756", "species_10478741", "species_10478727", "species_10478746", "species_10478764", "species_10478751" ], "modifiers": [ [ "species_10478768", "catalyst" ] ], "additional_components": [ "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791", "Q23983", "FBgn0250791", "FBgn0011708", "FBgn0260857", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "FBgn0260856", "M9PGI6", "FBgn0260855", "FBgn0264978", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10478996": { "compartment": "compartment_6791047", "id": "reaction_10478996", "reactome": "R-DME-5694446", "name": "BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478758", "species_10478892" ], "products": [ "species_10478994", "species_10478691", "species_10478684", "species_10478766" ], "modifiers": [], "additional_components": [ "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P49858", "FBgn0000339", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q7JYA0", "FBgn0033873", "Q9VWB4", "FBgn0036969", "Q4V3G2", "FBgn0034195", "Q9VVW1", "FBgn0015586", "Q3HKQ3", "FBgn0052203", "Q9VPH9", "FBgn0036970", "Q0E8V6", "FBgn0051902", "Q9VLZ8", "FBgn0083141", "Q0E8C8", "FBgn0262057", "Q9VLV3", "FBgn0053121", "A1Z6V5", "FBgn0024293", "Q9VLU4", "FBgn0031973", "A1Z6R4", "FBgn0033113", "Q9VLQ7", "FBgn0028987", "A1Z6R3", "FBgn0033112", "Q9VL44", "FBgn0032178", "A1Z6I3", "FBgn0263109", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q9V3A8", "FBgn0035909", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "Q9W3N6", "FBgn0040087", "M9PGI6", "FBgn0260855", "Q7JYA0", "FBgn0033873", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9V3A8", "FBgn0035909", "P49858", "FBgn0000339", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9W3N6", "FBgn0040087", "Q9VW57", "FBgn0036919", "Q9W289", "FBgn0034697", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708" ] }, "reaction_10487628": { "compartment": "compartment_6791047", "id": "reaction_10487628", "reactome": "R-DME-6814833", "name": "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487623" ], "products": [ "species_10478404", "species_10487621" ], "modifiers": [ [ "species_10487623", "catalyst" ] ], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W5H8", "FBgn0040005", "species_29420", "O18332", "FBgn0285937", "FBgn0040005", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W5H8", "FBgn0040005" ] }, "reaction_10478770": { "compartment": "compartment_6791047", "id": "reaction_10478770", "reactome": "R-DME-5694423", "name": "NSF and SNAPs bind cis-SNARE complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10478727", "species_10478766" ], "products": [ "species_10478768" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "M9PGI6", "FBgn0260855", "Q24179", "FBgn0264978", "Q9VRL2", "FBgn0260856", "Q9VVX6", "FBgn0260857", "Q24509", "FBgn0011708", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10442369": { "compartment": "compartment_70101", "id": "reaction_10442369", "reactome": "R-DME-203977", "name": "SAR1 Activation And Membrane Binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10442357" ], "products": [ "species_29420", "species_10442361" ], "modifiers": [ [ "species_10442366", "catalyst" ] ], "additional_components": [ "Q9VD29", "FBgn0038947", "species_29420", "Q9VD29", "FBgn0038947", "species_29438", "FBgn0031779" ] }, "reaction_10447503": { "compartment": "compartment_876", "id": "reaction_10447503", "reactome": "R-DME-418309", "name": "ATP2B1-4 transport cytosolic Ca2+ to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74016" ], "products": [ "species_74112" ], "modifiers": [ [ "species_10447494", "catalyst" ] ], "additional_components": [ "FBgn0259214" ] }, "reaction_10455452": { "compartment": "compartment_70101", "id": "reaction_10455452", "reactome": "R-DME-947591", "name": "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_947588", "species_113592" ], "products": [ "species_29372", "species_29370", "species_947594" ], "modifiers": [ [ "species_10455391", "catalyst" ] ], "additional_components": [ "species_33625", "species_1602375", "species_1602375", "species_33625", "B7YZF8", "FBgn0259221", "Q7KTG6", "FBgn0032120", "Q9VGD4", "FBgn0037989", "Q9VXG6", "FBgn0030747", "Q9VXG7", "FBgn0030746" ] }, "reaction_10447514": { "compartment": "compartment_114521", "id": "reaction_10447514", "reactome": "R-DME-418365", "name": "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427899", "species_74016" ], "products": [ "species_70106", "species_139827" ], "modifiers": [ [ "species_10447507", "catalyst" ] ], "additional_components": [] }, "reaction_10477993": { "compartment": "compartment_70101", "id": "reaction_10477993", "reactome": "R-DME-5692462", "name": "ATP13A1 transports Mn2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29418", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1981162" ], "modifiers": [ [ "species_10477990", "catalyst" ] ], "additional_components": [ "FBgn0027582" ] }, "reaction_10455270": { "compartment": "compartment_20699", "id": "reaction_10455270", "reactome": "R-DME-936883", "name": "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_74016" ], "products": [ "species_29372", "species_29370", "species_167012" ], "modifiers": [ [ "species_10455267", "catalyst" ] ], "additional_components": [ "M9PG15", "FBgn0052451", "species_29926" ] }, "reaction_10455334": { "compartment": "compartment_876", "id": "reaction_10455334", "reactome": "R-DME-937311", "name": "ATP4A/12A:ATP4B exchanges K+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_29356", "species_70106", "species_113592" ], "products": [ "species_351626", "species_29804", "species_29372", "species_29370" ], "modifiers": [ [ "species_10455331", "catalyst" ] ], "additional_components": [ "P13607", "FBgn0002921", "A8QI34", "FBgn0267363", "Q9VDY7", "FBgn0038691", "Q24046", "FBgn0015776", "Q9V3Q7", "FBgn0038690", "M9PDX8", "FBgn0032946", "Q7KT77", "FBgn0053310", "Q24048", "FBgn0015777" ] }, "reaction_10448436": { "compartment": "compartment_12045", "id": "reaction_10448436", "reactome": "R-DME-427910", "name": "ATP2A1-3 transport Ca2+ from cytosol to ER lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_74016" ], "products": [ "species_70106", "species_111875" ], "modifiers": [ [ "species_10448412", "catalyst" ], [ "species_10448434", "catalyst" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607" ] }, "reaction_10478001": { "compartment": "compartment_70101", "id": "reaction_10478001", "reactome": "R-DME-5692480", "name": "ATP13A2 transports cations from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5692450" ], "products": [ "species_29372", "species_29370", "species_5692484" ], "modifiers": [ [ "species_10477998", "catalyst" ] ], "additional_components": [ "FBgn0052000" ] }, "reaction_10448234": { "compartment": "compartment_876", "id": "reaction_10448234", "reactome": "R-DME-426086", "name": "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126", "species_188972", "species_74113" ], "products": [ "species_29804", "species_83910", "species_352022" ], "modifiers": [ [ "species_10448231", "catalyst" ] ], "additional_components": [ "M9PI37", "FBgn0036279", "Q9VNC7", "FBgn0051547" ] }, "reaction_10448243": { "compartment": "compartment_876", "id": "reaction_10448243", "reactome": "R-DME-426130", "name": "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_74113" ], "products": [ "species_83910", "species_352022" ], "modifiers": [ [ "species_10448240", "catalyst" ] ], "additional_components": [ "Q9VNC7", "FBgn0051547", "M9PI37", "FBgn0036279" ] }, "reaction_10464875": { "compartment": "compartment_70101", "id": "reaction_10464875", "reactome": "R-DME-2106614", "name": "Duplex miRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464873" ], "products": [ "species_10443056" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016" ] }, "reaction_10443076": { "compartment": "compartment_70101", "id": "reaction_10443076", "reactome": "R-DME-210805", "name": "Removal of miRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443056" ], "products": [ "species_10443074" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VLW8", "FBgn0031951" ] }, "reaction_10431293": { "compartment": "compartment_5460", "id": "reaction_10431293", "reactome": "R-DME-73916", "name": "2 acetyl-CoA <=> acetoacetyl-CoA + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559" ], "products": [ "species_29374", "species_73871" ], "modifiers": [ [ "species_10428434", "catalyst" ] ], "additional_components": [ "Q9W3N9", "FBgn0029969" ] }, "reaction_10431485": { "compartment": "compartment_5460", "id": "reaction_10431485", "reactome": "R-DME-74180", "name": "HMG CoA => acetoacetic acid + acetyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73917" ], "products": [ "species_113559", "species_73909" ], "modifiers": [ [ "species_10431482", "catalyst" ] ], "additional_components": [ "Q9VM58", "FBgn0031877" ] }, "reaction_10431291": { "compartment": "compartment_5460", "id": "reaction_10431291", "reactome": "R-DME-73912", "name": "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_73909", "species_29362" ], "products": [ "species_113526", "species_73911" ], "modifiers": [ [ "species_10431288", "catalyst" ] ], "additional_components": [ "Q7K3N4", "FBgn0033679" ] }, "reaction_10491097": { "compartment": "compartment_5460", "id": "reaction_10491097", "reactome": "R-DME-8875071", "name": "ACSS3 ligates CoA to CH3COO-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_113539" ], "products": [ "species_159448", "species_159450", "species_113559" ], "modifiers": [ [ "species_10491094", "catalyst" ] ], "additional_components": [ "FBgn0039184" ] }, "reaction_10479990": { "compartment": "compartment_70101", "id": "reaction_10479990", "reactome": "R-DME-6788597", "name": "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191374" ], "products": [ "species_76183", "species_29666" ], "modifiers": [ [ "species_10479987", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VM58", "FBgn0031877" ] }, "reaction_10431301": { "compartment": "compartment_5460", "id": "reaction_10431301", "reactome": "R-DME-73918", "name": "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73871", "species_113559" ], "products": [ "species_29374", "species_73917" ], "modifiers": [ [ "species_10431298", "catalyst" ] ], "additional_components": [ "FBgn0010611" ] }, "reaction_10479039": { "compartment": "compartment_20699", "id": "reaction_10479039", "reactome": "R-DME-5694487", "name": "A4GNT transfers GlcNAc to core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454881" ], "products": [ "species_10479031", "species_205687" ], "modifiers": [ [ "species_10479036", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "FBgn0031491" ] }, "reaction_10454637": { "compartment": "compartment_20699", "id": "reaction_10454637", "reactome": "R-DME-913675", "name": "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10454542" ], "products": [ "species_10454561", "species_205687" ], "modifiers": [ [ "species_10454634", "catalyst" ] ], "additional_components": [ "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9Y117", "FBgn0027558", "Q6WV17", "FBgn0031681", "Q8MV48", "FBgn0030930", "Q6WV19", "FBgn0031530", "Q6WV20", "FBgn0034025", "Q8MYY6", "FBgn0039596", "Q8MRC9", "FBgn0050463", "Q8MVS5", "FBgn0001970" ] }, "reaction_10462333": { "compartment": "compartment_20699", "id": "reaction_10462333", "reactome": "R-DME-1964505", "name": "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454561", "species_735682" ], "products": [ "species_205687", "species_10454862" ], "modifiers": [ [ "species_10462330", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VQH4", "FBgn0031466", "A8JNT3", "FBgn0085480", "Q9VQI0", "FBgn0031472", "Q7K237", "FBgn0032078", "A8JNT2", "FBgn0085481", "Q9VQH7", "FBgn0031469", "Q7JRF9", "FBgn0033271", "Q9W0L4", "FBgn0054056", "Q9VQH6", "FBgn0031468", "Q2PE08", "FBgn0054057", "Q9VWM1", "FBgn0030984" ] }, "reaction_10479773": { "compartment": "compartment_20699", "id": "reaction_10479773", "reactome": "R-DME-6786012", "name": "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454881", "species_741440" ], "products": [ "species_742343", "species_10479764" ], "modifiers": [ [ "species_10479770", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VMC4", "FBgn0031826", "Q9VMC3", "FBgn0051637" ] }, "reaction_10462269": { "compartment": "compartment_17963", "id": "reaction_10462269", "reactome": "R-DME-1964501", "name": "Addition of galactose to Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10454714" ], "products": [ "species_10462264", "species_205687" ], "modifiers": [ [ "species_10462266", "catalyst" ] ], "additional_components": [ "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10454716": { "compartment": "compartment_17963", "id": "reaction_10454716", "reactome": "R-DME-914008", "name": "Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454561" ], "products": [ "species_10454714", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004" ] }, "reaction_10454843": { "compartment": "compartment_20699", "id": "reaction_10454843", "reactome": "R-DME-914010", "name": "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454561" ], "products": [ "species_205687", "species_10454735" ], "modifiers": [ [ "species_10454840", "catalyst" ] ], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VZA6", "FBgn0035558", "Q95RP8", "FBgn0040373", "A1Z8R6", "FBgn0053145", "A1Z8R5", "FBgn0050037", "A1Z8R4", "FBgn0050036", "Q9VLT0", "FBgn0031986", "Q9VLS8", "FBgn0031988" ] }, "reaction_10454695": { "compartment": "compartment_17963", "id": "reaction_10454695", "reactome": "R-DME-914006", "name": "Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454561", "species_735682" ], "products": [ "species_10454693", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167" ] }, "reaction_10454902": { "compartment": "compartment_17963", "id": "reaction_10454902", "reactome": "R-DME-914017", "name": "Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10454561" ], "products": [ "species_10454900", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167" ] }, "reaction_10454674": { "compartment": "compartment_17963", "id": "reaction_10454674", "reactome": "R-DME-914005", "name": "Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_10454561" ], "products": [ "species_10454672", "species_205687" ], "modifiers": [], "additional_components": [ "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167", "Q0KHY3", "FBgn0051004", "A1Z877", "FBgn0026403", "Q9VU94", "FBgn0029167" ] }, "reaction_10470740": { "compartment": "compartment_12045", "id": "reaction_10470740", "reactome": "R-DME-5173192", "name": "POFUT2 transfers fucose to TSR domain-containing proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470732" ], "products": [ "species_10470564" ], "modifiers": [ [ "species_10470737", "catalyst" ] ], "additional_components": [ "Q9VM97", "FBgn0031850", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9W493", "FBgn0029791", "Q9W493", "FBgn0029791", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9VM97", "FBgn0031850", "FBgn0027791" ] }, "reaction_10470658": { "compartment": "compartment_12045", "id": "reaction_10470658", "reactome": "R-DME-5173005", "name": "B3GALTL transfers glucose to O-fucosyl-proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470564", "species_173594" ], "products": [ "species_158602", "species_10470650" ], "modifiers": [ [ "species_10470655", "catalyst" ] ], "additional_components": [ "Q9W493", "FBgn0029791", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9VM97", "FBgn0031850", "Q9W493", "FBgn0029791", "Q9W1Z6", "FBgn0086408", "Q8SXB0", "FBgn0286071", "Q7K3Y9", "FBgn0033710", "Q9VM97", "FBgn0031850", "FBgn0031765" ] }, "reaction_10449358": { "compartment": "compartment_984", "id": "reaction_10449358", "reactome": "R-DME-432164", "name": "Ca2+ influx into the post-synaptic cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10449355", "catalyst" ], [ "species_9635195", "inhibitor" ] ], "additional_components": [ "Q7KRY7", "FBgn0263289", "P18091", "FBgn0000667", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "Q00168", "FBgn0264607", "CHEBI:16523", "species_29424", "species_210382" ] }, "reaction_10449740": { "compartment": "compartment_876", "id": "reaction_10449740", "reactome": "R-DME-438037", "name": "Membrane depolarization upon activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10446948", "catalyst" ], [ "species_10449738", "catalyst" ] ], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q7KRY7", "FBgn0263289", "P18091", "FBgn0000667", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513", "P31007", "FBgn0001624", "Q9W450", "FBgn0029830", "CHEBI:16523", "species_29424", "species_210382" ] }, "reaction_10497396": { "compartment": "compartment_12045", "id": "reaction_10497396", "reactome": "R-DME-9609742", "name": "Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497390", "species_10497392" ], "products": [ "species_10497394" ], "modifiers": [], "additional_components": [ "FBgn0010399", "FBgn0053513", "Q9W581", "FBgn0053513", "Q24418", "FBgn0010399" ] }, "reaction_10497508": { "compartment": "compartment_12045", "id": "reaction_10497508", "reactome": "R-DME-9610750", "name": "GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497506" ], "products": [ "species_10449322" ], "modifiers": [], "additional_components": [ "Q9W581", "FBgn0053513", "Q24418", "FBgn0010399", "Q24418", "FBgn0010399", "Q9W581", "FBgn0053513" ] }, "reaction_10493706": { "compartment": "compartment_70101", "id": "reaction_10493706", "reactome": "R-DME-8951727", "name": "cAMP binds PKA tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434305", "species_30389" ], "products": [ "species_10434307" ], "modifiers": [], "additional_components": [ "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "species_30389", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243" ] }, "reaction_10434269": { "compartment": "compartment_7660", "id": "reaction_10434269", "reactome": "R-DME-111915", "name": "CAMK4 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10434260" ], "products": [ "species_113582", "species_10434266" ], "modifiers": [ [ "species_10434260", "catalyst" ] ], "additional_components": [ "Q7PLI7", "FBgn0261387", "species_74016", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q7PLI7", "FBgn0261387", "species_74016", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q7PLI7", "FBgn0261387", "species_74016", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273" ] }, "reaction_10435620": { "compartment": "compartment_70101", "id": "reaction_10435620", "reactome": "R-DME-157849", "name": "Formation of translation initiation complexes containing mRNA that does not circularize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435618", "species_10430440", "species_10430463" ], "products": [ "species_10430440", "species_10430508" ], "modifiers": [], "additional_components": [ "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10435555": { "compartment": "compartment_70101", "id": "reaction_10435555", "reactome": "R-DME-156808", "name": "Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430440", "species_10435546", "species_10435551", "species_10430463" ], "products": [ "species_10435553", "species_10430440" ], "modifiers": [], "additional_components": [ "FBgn0026250", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0265297", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P21187", "FBgn0265297", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0026250" ] }, "reaction_10497375": { "compartment": "compartment_13231", "id": "reaction_10497375", "reactome": "R-DME-9604308", "name": "NICD4 traffics to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497365" ], "products": [ "species_10443303" ], "modifiers": [ [ "species_10497373", "inhibitor" ] ], "additional_components": [ "FBgn0051665", "FBgn0051665", "P29310", "14-3-3zeta", "Q7KU08", "FBgn0051665" ] }, "reaction_10446682": { "compartment": "compartment_984", "id": "reaction_10446682", "reactome": "R-DME-390886", "name": "HRH4 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445670", "species_390899" ], "products": [ "species_10445672" ], "modifiers": [], "additional_components": [ "FBgn0000037", "species_390899", "P16395", "FBgn0000037" ] }, "reaction_10498568": { "compartment": "compartment_984", "id": "reaction_10498568", "reactome": "R-DME-9692880", "name": "HRH3 binds Hist", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390899", "species_10498564" ], "products": [ "species_10498566" ], "modifiers": [], "additional_components": [ "FBgn0000037", "P16395", "FBgn0000037", "species_390899" ] }, "reaction_10496054": { "compartment": "compartment_70101", "id": "reaction_10496054", "reactome": "R-DME-9009308", "name": "STUB1 polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496029", "species_10426987" ], "products": [ "species_10456460", "species_10496051" ], "modifiers": [ [ "species_10496029", "catalyst" ] ], "additional_components": [ "Q9XYW6", "FBgn0027052", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0027052", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "Q9XYW6", "FBgn0027052", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10492551": { "compartment": "compartment_7660", "id": "reaction_10492551", "reactome": "R-DME-8939706", "name": "SCF(SKP2) polyubiquitinates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10492520" ], "products": [ "species_10427449", "species_10492548" ], "modifiers": [ [ "species_10492520", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10496056": { "compartment": "compartment_70101", "id": "reaction_10496056", "reactome": "R-DME-9009309", "name": "RUNX2 binds STUB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496027", "species_10456460" ], "products": [ "species_10496029" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "FBgn0027052", "Q9XYW6", "FBgn0027052", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10492553": { "compartment": "compartment_7660", "id": "reaction_10492553", "reactome": "R-DME-8939801", "name": "26S proteasome degrades PolyUb-RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492548" ], "products": [ "species_10427430" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10492522": { "compartment": "compartment_7660", "id": "reaction_10492522", "reactome": "R-DME-8939688", "name": "SCF(SKP2) complex binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491656", "species_10427449" ], "products": [ "species_10492520" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_538904": { "compartment": "compartment_7660", "id": "reaction_538904", "reactome": "R-DME-538904", "name": "Phosphorylated PER binds to CLK", "reversible": "false", "notes": "After Timeless (TIM) and Period (PER) reform their heterodimer, PER binds to the E-box bound Clock (CLK) protein. Transcription of the per, tim, vri, and Pdp1 target genes is now deactivated. It appears that PER directly binds to CLK, whereas itself and TIM do not bind to Cycle (CYC). PER binding to CLK is in itself not sufficient for inhibition.", "reactants": [ "species_881986", "species_881995" ], "products": [ "species_882012" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_538891": { "compartment": "compartment_7660", "id": "reaction_538891", "reactome": "R-DME-538891", "name": "CLK:CYC heterodimer dissociates from per, tim, vri, and Pdp1 genes", "reversible": "false", "notes": "The deactivation of the Clock (CLK):Cycle (CYC) heterodimer and subsequent deactivation of the per, tim, vri, and Pdp1 target genes causes the CLK:CYC heterodimer to be released from its binding to its target genes, sequestered in a stable complex with PER and TIM to reinforce the transcription inhibition. Towards the end of the night Period (PER) and Timeless (TIM) proteins are at their peak level.", "reactants": [ "species_881925" ], "products": [ "species_881962", "species_29428" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC" ] }, "reaction_432513": { "compartment": "compartment_7660", "id": "reaction_432513", "reactome": "R-DME-432513", "name": "CLK is phosphorylated by DCO", "reversible": "false", "notes": "Clock (CLK) protein is now phosphorylated on unknown serine/threonine residues by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO). It is not yet known whether other kinases are involved in phosphorylating CLK, potentially brought to there via interactions with DCO and Period (PER) acting as scaffolding proteins. There is also evidence from mammalian systems that chromatin remodelling factors are brought in by the PER scaffold and are responsible for a sustained state of transcription inhibition in these genes.", "reactants": [ "species_29358", "species_882012" ], "products": [ "species_113582", "species_881925" ], "modifiers": [ [ "species_882012", "catalyst" ] ], "additional_components": [ "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432381": { "compartment": "compartment_7660", "id": "reaction_432381", "reactome": "R-DME-432381", "name": "PDP1 replaces VRI as binder to Clk and cry genes", "reversible": "false", "notes": "PAR domain protein-1 (PDP1) levels reach their peak between mid to late night. Vrille (VRI) levels decline during this time due to TIM:PER:DCO mediated repression of Clock (CLK) driven vri transcription. The decreasing ratio of VRI/PDP1 levels favours binding of PDP1 over VRI to the V/P boxes resulting in activation of Clk and cry transcription.", "reactants": [ "species_881990", "species_432423" ], "products": [ "species_432467", "species_881966" ], "modifiers": [], "additional_components": [ "Q9VMS4", "VRI", "Q24217", "PDP1" ] }, "reaction_538900": { "compartment": "compartment_7660", "id": "reaction_538900", "reactome": "R-DME-538900", "name": "Phosphorylated PER rebinds to phosphorylated TIM", "reversible": "false", "notes": "Once in the nucleus, phosphorylated Timeless (TIM) and Period (PER) reform their heterodimer.", "reactants": [ "species_881991", "species_432657" ], "products": [ "species_881995" ], "modifiers": [], "additional_components": [ "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO" ] }, "reaction_432516": { "compartment": "compartment_7660", "id": "reaction_432516", "reactome": "R-DME-432516", "name": "CLK and CYC bind to form a heterodimer", "reversible": "false", "notes": "The basic-helix-loop-helix PAS (PER-ARNT-SIM) domain transcription factors, Clock (CLK) and Cycle (CYC) bind and form a heterodimer.", "reactants": [ "species_432489", "species_432557" ], "products": [ "species_432591" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432436": { "compartment": "compartment_7660", "id": "reaction_432436", "reactome": "R-DME-432436", "name": "CLK:CYC heterodimer binds to per, tim, vri, and Pdp1 genes", "reversible": "false", "notes": "At midday, the Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target genes, per, tim, vri, and Pdp1. Transcription of these genes is now activated.", "reactants": [ "species_432591", "species_29428" ], "products": [ "species_881986" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432593": { "compartment": "compartment_70101", "id": "reaction_432593", "reactome": "R-DME-432593", "name": "Cytosolic JET binds to CRY, facilitating its ubiquitination", "reversible": "false", "notes": "After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY), facilitating its ubiquitination, marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.", "reactants": [ "species_206204", "species_432571", "species_432574" ], "products": [ "species_432576" ], "modifiers": [ [ "species_432571", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "O77059", "CRY", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_432428": { "compartment": "compartment_70101", "id": "reaction_432428", "reactome": "R-DME-432428", "name": "Cytosolic CRY is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated cryptochrome (CRY) is degraded by the 26S proteasome.", "reactants": [ "species_432576" ], "products": [ "species_206204", "species_432571" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "O77059", "CRY", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_432652": { "compartment": "compartment_7660", "id": "reaction_432652", "reactome": "R-DME-432652", "name": "Nuclear CRY is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated cryptochrome (CRY) is degraded by the 26S proteasome.", "reactants": [ "species_432418" ], "products": [ "species_432393", "species_216110" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "O77059", "CRY", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432378": { "compartment": "compartment_7660", "id": "reaction_432378", "reactome": "R-DME-432378", "name": "Nuclear JET binds CRY, facilitating its ubiquitination", "reversible": "false", "notes": "After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY), facilitating its ubiquitination and marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.", "reactants": [ "species_432393", "species_216110", "species_432582" ], "products": [ "species_432418" ], "modifiers": [ [ "species_432393", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O77059", "CRY", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET" ] }, "reaction_432510": { "compartment": "compartment_7660", "id": "reaction_432510", "reactome": "R-DME-432510", "name": "CLK is degraded by the 26S proteasome", "reversible": "false", "notes": "Hyperphosphorylated Clock (CLK) is degraded by the 26S proteasome via an unknown intermediate mechanism.", "reactants": [ "species_432621" ], "products": [ "species_432489" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432455": { "compartment": "compartment_7660", "id": "reaction_432455", "reactome": "R-DME-432455", "name": "Nuclear PER is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Period (PER) is degraded by the 26S proteasome.", "reactants": [ "species_882001" ], "products": [ "species_216110", "species_432621", "species_432399", "species_432469" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "O44382", "SLMB", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61734", "CYC", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61735", "Phospho CLK", "O61734", "CYC", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432483": { "compartment": "compartment_7660", "id": "reaction_432483", "reactome": "R-DME-432483", "name": "SLMB binds phosphorylated nuclear PER, facilitating its ubiquitination", "reversible": "false", "notes": "During the day, with levels of its stabilising partner Timeless (TIM) drastically reduced by light, hyperphosphorylated Period (PER) becomes a target for the F-box containing protein, supernumerary limbs (SLMB). Ser47 phosphorylation of Period (PER) appears to be the trigger for SLMB to bind phosphorylated PER, facilitating its ubiquitination and marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for PER degradation are the same.", "reactants": [ "species_216110", "species_881927", "species_432469" ], "products": [ "species_882001" ], "modifiers": [ [ "species_432469", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "O61734", "CYC", "O44382", "SLMB", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O61734", "CYC" ] }, "reaction_432411": { "compartment": "compartment_70101", "id": "reaction_432411", "reactome": "R-DME-432411", "name": "SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination", "reversible": "false", "notes": "During the day, with levels of its stabilising partner Timeless (TIM) drastically reduced by light, hyperphosphorylated Period (PER) becomes a target for the F-box containing protein, supernumerary limbs (SLMB). Ser47 phosphorylation of Period (PER) appears to be the trigger for SLMB to bind and facilitate ubiquitination of phosphorylated PER, marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for PER degradation are the same.", "reactants": [ "species_206204", "species_881987", "species_206299" ], "products": [ "species_881958" ], "modifiers": [ [ "species_206299", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O44382", "SLMB", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_432361": { "compartment": "compartment_70101", "id": "reaction_432361", "reactome": "R-DME-432361", "name": "Cytosolic PER is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Period (PER) is degraded by the 26S proteasome.", "reactants": [ "species_881958" ], "products": [ "species_206204", "species_206299", "species_205729" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O44382", "SLMB", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_432527": { "compartment": "compartment_7660", "id": "reaction_432527", "reactome": "R-DME-432527", "name": "Nuclear PP2A dephosphorylates phosphorylated PER", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Widerborst (WDB), helps stabilise hyperphosphorylated Period (PER) by dephosphorylating it and so prevent it from degradation. PP2A also seems to speed up nuclear import of PER. This is probably a secondary effect of stabilising PER.", "reactants": [ "species_881962" ], "products": [ "species_113550", "species_881965" ], "modifiers": [ [ "species_432603", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "P23696", "mts", "Q9VB23", "WDB", "P36179", "Pp2A-29B" ] }, "reaction_432556": { "compartment": "compartment_70101", "id": "reaction_432556", "reactome": "R-DME-432556", "name": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Twins (TWS), helps stabilise hyperphosphorylated Period (PER), within the PER:DCO complex, by dephosphorylating it and so prevent it from degradation. PP2A likely dephosphorylates the site phosphorylated by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) as it stabilises PER.", "reactants": [ "species_881987" ], "products": [ "species_432347", "species_29372" ], "modifiers": [ [ "species_206938", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_538822": { "compartment": "compartment_70101", "id": "reaction_538822", "reactome": "R-DME-538822", "name": "Cytosolic PP2A dephosphorylates phosphorylated PER complexed with TIM and DCO", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Twins (TWS), helps stabilise hyperphosphorylated Period (PER), within the PER:DCO complex, by dephosphorylating it and so prevent it from degradation. PP2A likely dephosphorylates the site phosphorylated by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) as it stabilises PER.", "reactants": [ "species_881967" ], "products": [ "species_29372", "species_432413" ], "modifiers": [ [ "species_206938", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_538824": { "compartment": "compartment_70101", "id": "reaction_538824", "reactome": "R-DME-538824", "name": "PP1 binds to phosphorylated TIM in complex with PER", "reversible": "false", "notes": "The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).", "reactants": [ "species_881944", "species_432645" ], "products": [ "species_882002" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "O76324", "DCO", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM" ] }, "reaction_432533": { "compartment": "compartment_70101", "id": "reaction_432533", "reactome": "R-DME-432533", "name": "PP1 binds to phosphorylated TIM", "reversible": "false", "notes": "The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).", "reactants": [ "species_432363", "species_432645" ], "products": [ "species_432543" ], "modifiers": [], "additional_components": [ "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P49021", "TIM" ] }, "reaction_538832": { "compartment": "compartment_70101", "id": "reaction_538832", "reactome": "R-DME-538832", "name": "PP1 dephosphorylates phosphorylated TIM in the complex with PER and DCO", "reversible": "false", "notes": "The protein phosphatase, PP1, dephosphorylates and stabilises Timeless (TIM) which helps promote the accumulation of Period (PER).", "reactants": [ "species_882002" ], "products": [ "species_29372", "species_881912", "species_432645" ], "modifiers": [ [ "species_882002", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P49021", "TIM", "P07663", "Phospho (multi-site 2) PER", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "O76324", "DCO", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM" ] }, "reaction_432427": { "compartment": "compartment_70101", "id": "reaction_432427", "reactome": "R-DME-432427", "name": "PP1 dephosphorylates phosphorylated TIM", "reversible": "false", "notes": "The protein phosphatase, PP1, dephosphorylates and stabilises Timeless (TIM) which helps promote the accumulation of Period (PER).", "reactants": [ "species_432543" ], "products": [ "species_29372", "species_432355", "species_432645" ], "modifiers": [ [ "species_432543", "catalyst" ] ], "additional_components": [ "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P49021", "TIM", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "Q05547", "PP1-13C", "P48461", "PP1alpha-96A", "P48462", "flw", "P12982", "PP1-87B", "P49021", "TIM" ] }, "reaction_432642": { "compartment": "compartment_13231", "id": "reaction_432642", "reactome": "R-DME-432642", "name": "Phosphorylated TIM transports from the cytosol to the nucleus", "reversible": "false", "notes": "After the phosphorylated Period (PER):Discs Overgrown (DCO) complex has entered the nucleus, phosphorylated Timeless (TIM) does the same. The time frame between the two events appears to be variable, depending on the type of neuronal clock cell, and can be up to a few hours later. It is currently not known whether casein kinase II (CK2) is bound to PER and/or TIM and whether it travels with either from the cytosol to the nucleus.", "reactants": [ "species_432363" ], "products": [ "species_432657" ], "modifiers": [], "additional_components": [] }, "reaction_432544": { "compartment": "compartment_13231", "id": "reaction_432544", "reactome": "R-DME-432544", "name": "Phosphorylated PER transports from the cytosol to the nucleus", "reversible": "false", "notes": "Phosphorylated Period (PER):Discs Overgrown (DCO) complex is imported into the nucleus from the cytosol.", "reactants": [ "species_882007" ], "products": [ "species_881991" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO" ] }, "reaction_432371": { "compartment": "compartment_7660", "id": "reaction_432371", "reactome": "R-DME-432371", "name": "CRY is activated by light and binds to phosphorylated nuclear TIM", "reversible": "false", "notes": "At dawn, a light-induced conformational change in the blue-light photoreceptor cryptochrome (CRY) promotes the formation of a complex with phosphorylated Timeless (TIM). In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for TIM degradation are the same. Also, in flies kept in constant darkness for many days, TIM levels still undergo daily oscillations, although not as robust as in light-dark cycles. The mechanism that drives daily cycles in TIM levels during extended periods in complete darkness is not clear.", "reactants": [ "species_881962", "species_432582" ], "products": [ "species_881922", "species_881927" ], "modifiers": [ [ "species_432508", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "O61734", "CYC", "O77059", "CRY", "P49021", "TIM", "O61735", "Phospho CLK", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "O61734", "CYC" ] }, "reaction_432401": { "compartment": "compartment_70101", "id": "reaction_432401", "reactome": "R-DME-432401", "name": "JET binds cytosolic TIM, facilitating its ubiquitination", "reversible": "false", "notes": "There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and TIM helps promote the interaction between the F-box domain containing protein JET with TIM. This interaction targets TIM for ubiquitination, marking it for processing by the 26S proteasome.", "reactants": [ "species_206204", "species_432571", "species_881918" ], "products": [ "species_881984", "species_432574" ], "modifiers": [ [ "species_432571", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P49021", "TIM", "O77059", "CRY", "P49021", "TIM", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_432426": { "compartment": "compartment_70101", "id": "reaction_432426", "reactome": "R-DME-432426", "name": "CRY is activated by light and binds to cytosolic TIM", "reversible": "false", "notes": "At dawn, a light-induced conformational change in the blue-light photoreceptor cryptochrome (CRY) promotes the formation of a complex with Timeless (TIM). In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for TIM degradation are the same. Also, in flies kept in constant darkness for many days, TIM levels still undergo daily oscillations, although not as robust as in light-dark cycles. The mechanism that drives daily cycles in TIM levels during extended periods in complete darkness is not clear.", "reactants": [ "species_432574", "species_432355" ], "products": [ "species_881918" ], "modifiers": [ [ "species_432604", "catalyst" ] ], "additional_components": [ "P49021", "TIM", "O77059", "CRY" ] }, "reaction_432507": { "compartment": "compartment_70101", "id": "reaction_432507", "reactome": "R-DME-432507", "name": "Cytosolic TIM is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.", "reactants": [ "species_881984" ], "products": [ "species_206204", "species_432571" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "P49021", "TIM", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_432424": { "compartment": "compartment_7660", "id": "reaction_432424", "reactome": "R-DME-432424", "name": "JET binds phosphorylated nuclear TIM, facilitating its ubiquitination", "reversible": "false", "notes": "There is competition for binding to the E3 ligase protein Jetlag (JET) from both Timeless (TIM) and cryptochrome (CRY), with TIM being the stronger binder. The initial complex formed between CRY and phosphorylated TIM helps promote the interaction between the F-box domain containing protein JET with phosphorylated TIM, facilitating ubiquitination of the latter protein, marking it for processing by the 26S proteasome.", "reactants": [ "species_432393", "species_881922", "species_216110" ], "products": [ "species_882000", "species_432582" ], "modifiers": [ [ "species_432393", "catalyst" ] ], "additional_components": [ "O77059", "CRY", "P49021", "TIM", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P49021", "TIM", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET" ] }, "reaction_432521": { "compartment": "compartment_7660", "id": "reaction_432521", "reactome": "R-DME-432521", "name": "Nuclear TIM is degraded by the 26S proteasome", "reversible": "false", "notes": "Ubiquitinated phosphorylated Timeless (TIM) is degraded by the 26S proteasome.", "reactants": [ "species_882000" ], "products": [ "species_432393", "species_216110" ], "modifiers": [ [ "species_216160", "catalyst" ] ], "additional_components": [ "P49021", "TIM", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0E8", "JET", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P12881", "Prosalpha6", "Q7KMP8", "Rpn9", "P40304", "Prosbeta6", "Q9Y1A7", "MND", "Q9VW54", "Rpn1", "Q9VKZ8", "Usp14", "Q9V436", "Rpn12", "Q9V3G7", "Rpn7", "O18413", "Rpt6", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q9VNA5", "Prosbeta7", "P55035", "Rpn10", "Q9XZ61", "Uch-L5", "Q9V3Z4", "Rpn5", "Q7KMQ0", "Rpt1", "Q95083", "Prosalpha5", "Q9V3P6", "Rpn2", "Q8SYQ2", "I(2)05070", "Q9NHX7", "PROSbeta5", "Q9XYN7", "Prosbeta3", "Q9V405", "Rpt3", "Q9VUJ1", "Prosbeta2", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q9U7A2", "RPT4", "P48601", "Rpt2", "P40301", "Prosalpha2", "Q9V3V6", "Rpt5", "Q9VJJ0", "Prosbeta4", "Q9VM46", "CG13779", "Q9XZJ4", "Prosalpha1", "P22769", "Prosalpha4" ] }, "reaction_432487": { "compartment": "compartment_7660", "id": "reaction_432487", "reactome": "R-DME-432487", "name": "CWO binds to cwo gene and represses transcription", "reversible": "false", "notes": "Clockwork Orange (CWO) binds to the E-box of its own gene, cwo, and represses it's own transcription in a negative feedback loop.", "reactants": [ "species_29428", "species_432566" ], "products": [ "species_881926" ], "modifiers": [], "additional_components": [ "Q9VGZ5", "CWO" ] }, "reaction_432520": { "compartment": "compartment_7660", "id": "reaction_432520", "reactome": "R-DME-432520", "name": "CLK:CYC heterodimer binds to cwo gene and activates transcription", "reversible": "false", "notes": "The Clock (CLK):Cycle (CYC) heteodimer binds the E-box regulatory elements of the target gene, cwo. Transcription of cwo is now activated.", "reactants": [ "species_432591", "species_29428" ], "products": [ "species_881986" ], "modifiers": [], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "O61734", "CYC" ] }, "reaction_432647": { "compartment": "compartment_70101", "id": "reaction_432647", "reactome": "R-DME-432647", "name": "Phosphorylated PER binds to TIM", "reversible": "false", "notes": "After dusk, per and tim genes continue to be transcribed and their mRNAs reach peak levels between during the early part of the night. Timeless (TIM) protein is stable in the dark and so begins to accumulate and forms a complex with Period (PER) and Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). TIM stabilises PER despite the continuous attentions of casein kinase II (CK2) and DCO. As a result, PER and TIM accumulate to high levels during the middle of the night.", "reactants": [ "species_881987", "species_432355" ], "products": [ "species_881967" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM" ] }, "reaction_432535": { "compartment": "compartment_70101", "id": "reaction_432535", "reactome": "R-DME-432535", "name": "TIM is phosphorylated by CK2", "reversible": "false", "notes": "Timeless (TIM) is phosphorylated on unknown serine/threonine residues by casein kinase II (CK2). CK2 phosphorylation appears to be important for subsequent nuclear entry of TIM.", "reactants": [ "species_113592", "species_881912" ], "products": [ "species_29370", "species_881944" ], "modifiers": [ [ "species_206956", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P49021", "TIM", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "P11346", "Raf", "Q7KNQ9", "cnk", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P92177", "14-3-3epsilon", "Q9V9J3", "phospho-Src42A", "Q8ML92", "AVE", "P08646", "RAS85D", "species_29438", "Q24170", "Phospho KSR" ] }, "reaction_432464": { "compartment": "compartment_70101", "id": "reaction_432464", "reactome": "R-DME-432464", "name": "Phosphorylated TIM:PER heterodimer dissociate", "reversible": "false", "notes": "The phosphorylation of Timeless (TIM) and Period (PER) by casein kinase II (CK2) appears to be the trigger for their nuclear entry. However, before this occurs, phosphorylated TIM dissociates from the PER:Discs Overgrown (DCO) complex.", "reactants": [ "species_881944" ], "products": [ "species_432363", "species_882007" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER" ] }, "reaction_432590": { "compartment": "compartment_70101", "id": "reaction_432590", "reactome": "R-DME-432590", "name": "Phosphorylated PER is phosphorylated by CK2", "reversible": "false", "notes": "Phosphorylated Period (PER) is phosphorylated on serine residues 149, 151, 153, by casein kinase II (CK2). CK2 phosphorylation appears to be important for subsequent nuclear entry of PER.", "reactants": [ "species_113592", "species_881967" ], "products": [ "species_29370", "species_881912" ], "modifiers": [ [ "species_206956", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P49021", "TIM", "O76324", "DCO", "P49021", "TIM", "P07663", "Phospho (multi-site 2) PER", "P11346", "Raf", "Q7KNQ9", "cnk", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P92177", "14-3-3epsilon", "Q9V9J3", "phospho-Src42A", "Q8ML92", "AVE", "P08646", "RAS85D", "species_29438", "Q24170", "Phospho KSR" ] }, "reaction_432559": { "compartment": "compartment_70101", "id": "reaction_432559", "reactome": "R-DME-432559", "name": "PER is phosphorylated by DCO", "reversible": "false", "notes": "Period (PER) is phosphorylated on between 15-20 individual serine and threonine sites by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). During the day, when light activated regulation of Timeless (TIM) occurs and its levels are low, phosphorylated PER is susceptible to supernumerary limbs (SLMB) mediated ubiquitination and degradation. Ser47 and possibly other phosphorylated residues nearby are key phospho-signals on PER mediating the binding of SLMB to PER.", "reactants": [ "species_432347", "species_113592" ], "products": [ "species_881987", "species_29370" ], "modifiers": [ [ "species_206741", "catalyst" ] ], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_881988": { "compartment": "compartment_70101", "id": "reaction_881988", "reactome": "R-DME-881988", "name": "CRY is phosphorylated by SGG", "reversible": "false", "notes": "The blue-light photoreceptor cryptochrome (CRY) is phosphorylated on unknown serine/threonine residues by GSK3beta kinase orthologue, Shaggy (SGG). Phosphorylation appears to attenuate the function of CRY and it doesn't degrade Timeless (TIM). Earlier studies suggested that the effect of SGG on the light-mediated degradation of TIM was due to direct phosphorylation of TIM by SGG (Martinek et al., 2001), however, more recent experiments suggest the actual target of SGG in this pathway is CRY (Storelu et al., 2007).", "reactants": [ "species_113592", "species_432574" ], "products": [ "species_29370", "species_882013" ], "modifiers": [ [ "species_206898", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_538835": { "compartment": "compartment_70101", "id": "reaction_538835", "reactome": "R-DME-538835", "name": "PER binds to DCO", "reversible": "false", "notes": "The Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT) forms a complex with Period (PER).", "reactants": [ "species_432515", "species_205729" ], "products": [ "species_432347" ], "modifiers": [], "additional_components": [ "O76324", "DCO", "P07663", "Phospho (multi-site 2) PER" ] }, "reaction_432537": { "compartment": "compartment_7660", "id": "reaction_432537", "reactome": "R-DME-432537", "name": "PP2A dephosphorylates phosphorylated CLK", "reversible": "false", "notes": "The protein phosphatase PP2A, formed of PP2A-29B:Microtubule star (MTS):Widerborst (WDB), helps stabilise hyperphosphorylated Clock (CLK) by dephosphorylating it and so prevent it from degradation. CLK levels remain relatively constant because hypophosphorylated CLK is generated by de novo synthesis or by dephosphorylation of existent hyperphosphorylated CLK.", "reactants": [ "species_432621" ], "products": [ "species_113550", "species_432591" ], "modifiers": [ [ "species_432603", "catalyst" ] ], "additional_components": [ "O61735", "Phospho CLK", "O61734", "CYC", "O61735", "Phospho CLK", "O61734", "CYC", "P23696", "mts", "Q9VB23", "WDB", "P36179", "Pp2A-29B" ] }, "reaction_10456268": { "compartment": "compartment_876", "id": "reaction_10456268", "reactome": "R-DME-981713", "name": "C4b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437245", "species_983438" ], "products": [ "species_10456122" ], "modifiers": [], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10456252": { "compartment": "compartment_876", "id": "reaction_10456252", "reactome": "R-DME-981539", "name": "C3b binds to cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437285", "species_983438" ], "products": [ "species_10456083" ], "modifiers": [], "additional_components": [ "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10438059": { "compartment": "compartment_984", "id": "reaction_10438059", "reactome": "R-DME-173739", "name": "Spontaneous hydrolysis of C3 thioester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10437271" ], "products": [ "species_10438057" ], "modifiers": [], "additional_components": [ "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10431519": { "compartment": "compartment_70101", "id": "reaction_10431519", "reactome": "R-DME-74242", "name": "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500172" ], "products": [ "species_113599", "species_500244" ], "modifiers": [ [ "species_10431516", "catalyst" ] ], "additional_components": [ "CHEBI:28997", "species_83927", "CHEBI:28542", "species_112016", "Q9W1K6", "FBgn0034898", "M9PE19", "FBgn0035348" ] }, "reaction_10431551": { "compartment": "compartment_70101", "id": "reaction_10431551", "reactome": "R-DME-74255", "name": "Guanine + H2O => Xanthine + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_83956" ], "products": [ "species_31633", "species_30064" ], "modifiers": [ [ "species_10431548", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VMY9", "FBgn0261436" ] }, "reaction_10431529": { "compartment": "compartment_70101", "id": "reaction_10431529", "reactome": "R-DME-74247", "name": "Hypoxanthine + H2O + O2 => Xanthine + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113599", "species_29356", "species_29368" ], "products": [ "species_29408", "species_30064" ], "modifiers": [ [ "species_10431526", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "P10351", "FBgn0003308" ] }, "reaction_10466119": { "compartment": "compartment_70101", "id": "reaction_10466119", "reactome": "R-DME-2509838", "name": "ITPA hydrolyses dITP to dIMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509835", "species_29356" ], "products": [ "species_111294", "species_109330" ], "modifiers": [ [ "species_10466110", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VMW7", "FBgn0031663" ] }, "reaction_10431541": { "compartment": "compartment_70101", "id": "reaction_10431541", "reactome": "R-DME-74249", "name": "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500245" ], "products": [ "species_83956", "species_500244" ], "modifiers": [ [ "species_10431516", "catalyst" ] ], "additional_components": [ "CHEBI:17172", "CHEBI:16750", "CHEBI:28542", "species_112016", "Q9W1K6", "FBgn0034898", "M9PE19", "FBgn0035348" ] }, "reaction_10465661": { "compartment": "compartment_70101", "id": "reaction_10465661", "reactome": "R-DME-2395879", "name": "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395883", "species_29356" ], "products": [ "species_2395817", "species_29372" ], "modifiers": [ [ "species_10465656", "catalyst" ] ], "additional_components": [ "FBgn0037911" ] }, "reaction_10465659": { "compartment": "compartment_70101", "id": "reaction_10465659", "reactome": "R-DME-2395873", "name": "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2395880" ], "products": [ "species_29372", "species_2395877" ], "modifiers": [ [ "species_10465656", "catalyst" ] ], "additional_components": [ "FBgn0037911" ] }, "reaction_10465590": { "compartment": "compartment_5460", "id": "reaction_10465590", "reactome": "R-DME-2393954", "name": "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2393945", "species_113521" ], "products": [ "species_2393950", "species_159448" ], "modifiers": [ [ "species_10465587", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VV83", "FBgn0036648" ] }, "reaction_10465664": { "compartment": "compartment_70101", "id": "reaction_10465664", "reactome": "R-DME-2395965", "name": "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2395963", "species_29356" ], "products": [ "species_29372", "species_2395964" ], "modifiers": [ [ "species_10465656", "catalyst" ] ], "additional_components": [ "FBgn0037911" ] }, "reaction_10466116": { "compartment": "compartment_70101", "id": "reaction_10466116", "reactome": "R-DME-2509831", "name": "ITPA hydrolyses XTP to XMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2509848", "species_29356" ], "products": [ "species_111294", "species_111584" ], "modifiers": [ [ "species_10466110", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VMW7", "FBgn0031663" ] }, "reaction_10433331": { "compartment": "compartment_984", "id": "reaction_10433331", "reactome": "R-DME-109278", "name": "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_500101" ], "products": [ "species_500104", "species_109277" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_29602", "species_76577", "species_5696194", "species_109386", "species_83927", "CHEBI:16750", "species_83908", "CHEBI:17256", "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10431539": { "compartment": "compartment_70101", "id": "reaction_10431539", "reactome": "R-DME-74248", "name": "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500120", "species_29356" ], "products": [ "species_29372", "species_500118" ], "modifiers": [ [ "species_10431536", "catalyst" ] ], "additional_components": [ "species_29602", "species_109330", "species_5696194", "CHEBI:16192", "CHEBI:17172", "CHEBI:28997", "species_83927", "CHEBI:16750", "Q9VWV5", "FBgn0052549", "species_29926" ] }, "reaction_10431553": { "compartment": "compartment_70101", "id": "reaction_10431553", "reactome": "R-DME-74258", "name": "Xanthine + H2O + O2 => Urate + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_30064" ], "products": [ "species_30034", "species_29408" ], "modifiers": [ [ "species_10431526", "catalyst" ] ], "additional_components": [ "CHEBI:44074", "species_113596", "P10351", "FBgn0003308" ] }, "reaction_10466113": { "compartment": "compartment_70101", "id": "reaction_10466113", "reactome": "R-DME-2509827", "name": "ITPA hydrolyses ITP to IMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2509836" ], "products": [ "species_111294", "species_29602" ], "modifiers": [ [ "species_10466110", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VMW7", "FBgn0031663" ] }, "reaction_10465084": { "compartment": "compartment_70101", "id": "reaction_10465084", "reactome": "R-DME-2161701", "name": "PGH2 is isomerised to PGD2 by HPGDS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_879629" ], "modifiers": [ [ "species_10465081", "catalyst" ] ], "additional_components": [ "P41043", "FBgn0010226", "species_29450" ] }, "reaction_10443627": { "compartment": "compartment_70101", "id": "reaction_10443627", "reactome": "R-DME-265295", "name": "Prostaglandin E synthase isomerizes PGH2 to PGE2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10443624", "catalyst" ] ], "additional_components": [ "Q9VH95", "FBgn0037728", "Q9V420", "FBgn0004465" ] }, "reaction_10465079": { "compartment": "compartment_12045", "id": "reaction_10465079", "reactome": "R-DME-2161660", "name": "PGH2 is isomerised to PGE2 by PTGES", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265283" ], "products": [ "species_265287" ], "modifiers": [ [ "species_10465076", "catalyst" ] ], "additional_components": [ "species_29450", "Q8SY19", "FBgn0025814", "Q86B54", "FBgn0053177", "X2JF29", "FBgn0053178" ] }, "reaction_10465060": { "compartment": "compartment_70101", "id": "reaction_10465060", "reactome": "R-DME-2161614", "name": "PGD2 is reduced to 11-epi-PGF2a by AKRIC3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_879629" ], "products": [ "species_29366", "species_2142710" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10465057": { "compartment": "compartment_70101", "id": "reaction_10465057", "reactome": "R-DME-2161549", "name": "PGH2 is reduced to PGF2a by AKR1C3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_265283", "species_29364" ], "products": [ "species_29366", "species_879535" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10474576": { "compartment": "compartment_7660", "id": "reaction_10474576", "reactome": "R-DME-5651828", "name": "PARG dePARylates PARP1,PARP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10474566" ], "products": [ "species_5651834", "species_10474568" ], "modifiers": [ [ "species_10474573", "catalyst" ] ], "additional_components": [ "P35875", "FBgn0010247", "P35875", "FBgn0010247", "FBgn0023216" ] }, "reaction_10433082": { "compartment": "compartment_70101", "id": "reaction_10433082", "reactome": "R-DME-76590", "name": "AMP + H2O => IMP + NH4+ (AMPD)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_76577" ], "products": [ "species_29602", "species_31633" ], "modifiers": [ [ "species_10433079", "catalyst" ] ], "additional_components": [ "X2JEY5", "FBgn0052626" ] }, "reaction_10431497": { "compartment": "compartment_70101", "id": "reaction_10431497", "reactome": "R-DME-74213", "name": "Adenine + PRPP => AMP + PPi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_83951" ], "products": [ "species_111294", "species_76577" ], "modifiers": [ [ "species_10431494", "catalyst" ] ], "additional_components": [ "P12426", "FBgn0000109" ] }, "reaction_10465047": { "compartment": "compartment_70101", "id": "reaction_10465047", "reactome": "R-DME-2161187", "name": "N6-methyl-AMP + H2O => IMP + methylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161190" ], "products": [ "species_2161177", "species_29602" ], "modifiers": [ [ "species_10465044", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VHH7", "FBgn0037661" ] }, "reaction_10433411": { "compartment": "compartment_70101", "id": "reaction_10433411", "reactome": "R-DME-109624", "name": "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500173", "species_113592" ], "products": [ "species_500088", "species_29370" ], "modifiers": [ [ "species_10433408", "catalyst" ] ], "additional_components": [ "species_83908", "CHEBI:17256", "species_76577", "species_109386", "Q9VU38", "FBgn0283494", "species_29926" ] }, "reaction_10458882": { "compartment": "compartment_876", "id": "reaction_10458882", "reactome": "R-DME-1299338", "name": "Activation of TRESK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458879", "catalyst" ] ], "additional_components": [ "Q9W2L7", "FBgn0085425" ] }, "reaction_10456063": { "compartment": "compartment_70101", "id": "reaction_10456063", "reactome": "R-DME-977348", "name": "PHGHD tetramer dehydrogenates 3PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29360", "species_29728" ], "products": [ "species_977329", "species_70106", "species_73473" ], "modifiers": [ [ "species_10456060", "catalyst" ] ], "additional_components": [ "Q9VKI8", "FBgn0032350" ] }, "reaction_10456042": { "compartment": "compartment_70101", "id": "reaction_10456042", "reactome": "R-DME-977324", "name": "PSPH:Mg2+ dimer dephosphorylates O-P-Ser", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_936706" ], "products": [ "species_29372", "species_200736" ], "modifiers": [ [ "species_10456039", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VSY6", "FBgn0023129" ] }, "reaction_10491958": { "compartment": "compartment_70101", "id": "reaction_10491958", "reactome": "R-DME-8932980", "name": "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736" ], "products": [ "species_8932979" ], "modifiers": [ [ "species_10491947", "catalyst" ] ], "additional_components": [ "FBgn0028399" ] }, "reaction_10456053": { "compartment": "compartment_70101", "id": "reaction_10456053", "reactome": "R-DME-977333", "name": "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_977329", "species_29404" ], "products": [ "species_29406", "species_936706" ], "modifiers": [ [ "species_10456050", "catalyst" ] ], "additional_components": [ "Q9VAN0", "FBgn0014427" ] }, "reaction_10469871": { "compartment": "compartment_7660", "id": "reaction_10469871", "reactome": "R-DME-4568914", "name": "SUMOylation of BLM with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469863" ], "products": [ "species_10467222", "species_10469869" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0002906", "FBgn0010602", "FBgn0002906", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469853": { "compartment": "compartment_7660", "id": "reaction_10469853", "reactome": "R-DME-4551768", "name": "PIAS4 SUMOylates PARP1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10465325" ], "products": [ "species_10467222", "species_10469851" ], "modifiers": [ [ "species_10469560", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010247", "FBgn0010602", "FBgn0010247", "FBgn0003612" ] }, "reaction_10469847": { "compartment": "compartment_7660", "id": "reaction_10469847", "reactome": "R-DME-4551738", "name": "SUMOylation of TDG with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10433855" ], "products": [ "species_10469845", "species_10467222" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0026869", "FBgn0026869", "FBgn0010602", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469893": { "compartment": "compartment_7660", "id": "reaction_10469893", "reactome": "R-DME-4570463", "name": "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469883" ], "products": [ "species_10469891", "species_10467222" ], "modifiers": [ [ "species_10467488", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "FBgn0010602", "P26017", "FBgn0003042", "Q9VB08", "FBgn0003330", "Q9VHA0", "FBgn0003334", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "P39769", "FBgn0004861", "Q9VKL0", "FBgn0032330", "Q9W523", "FBgn0004860" ] }, "reaction_10469936": { "compartment": "compartment_7660", "id": "reaction_10469936", "reactome": "R-DME-4570553", "name": "SUMOylation of MDC1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469926" ], "products": [ "species_10467222", "species_10469934" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q95RC8", "FBgn0002872", "Q9VUB7", "FBgn0052133", "FBgn0010602", "Q9VUB7", "FBgn0052133", "Q95RC8", "FBgn0002872", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469840": { "compartment": "compartment_7660", "id": "reaction_10469840", "reactome": "R-DME-4551616", "name": "SUMOylation of RPA1 (RPA70) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10427308" ], "products": [ "species_10467222", "species_10469838" ], "modifiers": [ [ "species_10467300", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010173", "FBgn0010602", "FBgn0010173", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10435033": { "compartment": "compartment_114521", "id": "reaction_10435033", "reactome": "R-DME-139854", "name": "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_139827" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10435030", "catalyst" ] ], "additional_components": [ "species_114520", "species_74016", "P29993", "FBgn0010051" ] }, "reaction_10473205": { "compartment": "compartment_876", "id": "reaction_10473205", "reactome": "R-DME-5617178", "name": "ATP2B4 binds to NOS1, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447516", "species_10447500" ], "products": [ "species_10473203" ], "modifiers": [], "additional_components": [ "FBgn0011676", "FBgn0259214", "Q59DP9", "FBgn0259214", "Q27571", "FBgn0011676" ] }, "reaction_10464851": { "compartment": "compartment_70101", "id": "reaction_10464851", "reactome": "R-DME-2089943", "name": "TRPC1 translocates calcium from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10464846", "catalyst" ] ], "additional_components": [ "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "P83094", "Stim" ] }, "reaction_10471073": { "compartment": "compartment_12045", "id": "reaction_10471073", "reactome": "R-DME-5226904", "name": "AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457748", "species_10471069" ], "products": [ "species_10471071" ], "modifiers": [], "additional_components": [ "species_114520", "P29993", "FBgn0010051", "Q9VZX9", "FBgn0035371", "P50245", "FBgn0015011", "species_427523", "Q9VZX9", "FBgn0035371", "P50245", "FBgn0015011", "species_427523", "species_114520", "P29993", "FBgn0010051" ] }, "reaction_10473217": { "compartment": "compartment_70101", "id": "reaction_10473217", "reactome": "R-DME-5617179", "name": "PRKACA phosphorylates TNNI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10473210" ], "products": [ "species_29370", "species_10473214" ], "modifiers": [ [ "species_10434289", "catalyst" ], [ "species_10473203", "catalyst" ] ], "additional_components": [ "FBgn0283471", "FBgn0283471", "Q59DP9", "FBgn0259214", "Q27571", "FBgn0011676" ] }, "reaction_10466954": { "compartment": "compartment_70101", "id": "reaction_10466954", "reactome": "R-DME-2730894", "name": "NFKB1:RELA translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10441907": { "compartment": "compartment_70101", "id": "reaction_10441907", "reactome": "R-DME-202328", "name": "Translocation of PKC theta to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112275", "species_10441582" ], "products": [ "species_10441905" ], "modifiers": [], "additional_components": [ "FBgn0259680", "P83099", "FBgn0259680", "species_112275" ] }, "reaction_10472898": { "compartment": "compartment_70101", "id": "reaction_10472898", "reactome": "R-DME-5607724", "name": "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472896" ], "products": [ "species_10437411" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q03017", "phospho-cact", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10466833": { "compartment": "compartment_70101", "id": "reaction_10466833", "reactome": "R-DME-2730835", "name": "Autophosphorylation of PKC-theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441891", "species_113592" ], "products": [ "species_29370", "species_10466831" ], "modifiers": [], "additional_components": [ "species_112275", "P83099", "FBgn0259680", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10458269": { "compartment": "compartment_70101", "id": "reaction_10458269", "reactome": "R-DME-1237129", "name": "Acireductone is created", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1237176" ], "products": [ "species_29372", "species_70106", "species_1237155" ], "modifiers": [ [ "species_10458266", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VN95", "FBgn0037305" ] }, "reaction_10458249": { "compartment": "compartment_70101", "id": "reaction_10458249", "reactome": "R-DME-1237096", "name": "Methylthio-ribose-P = Methylthio-ribulose-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1237165" ], "products": [ "species_1237107" ], "modifiers": [ [ "species_10458246", "catalyst" ] ], "additional_components": [ "FBgn0039849" ] }, "reaction_10458279": { "compartment": "compartment_70101", "id": "reaction_10458279", "reactome": "R-DME-1237160", "name": "MTA is cleaved and phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_353106" ], "products": [ "species_1237165", "species_83951" ], "modifiers": [ [ "species_10458276", "catalyst" ] ], "additional_components": [ "Q9V813", "FBgn0034215" ] }, "reaction_10458259": { "compartment": "compartment_70101", "id": "reaction_10458259", "reactome": "R-DME-1237119", "name": "Acireductone is oxidized to MOB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_1237155" ], "products": [ "species_29460", "species_1237122" ], "modifiers": [ [ "species_10458256", "catalyst" ] ], "additional_components": [ "Q6AWN0", "FBgn0052068", "species_111793" ] }, "reaction_10455900": { "compartment": "compartment_20699", "id": "reaction_10455900", "reactome": "R-DME-975919", "name": "Addition of galactose by beta 4-galactosyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_975910" ], "products": [ "species_981618" ], "modifiers": [ [ "species_10455897", "catalyst" ] ], "additional_components": [ "Q9VAQ8", "FBgn0039625", "Q7KN92", "FBgn0027538" ] }, "reaction_10455845": { "compartment": "compartment_20699", "id": "reaction_10455845", "reactome": "R-DME-975903", "name": "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981616" ], "modifiers": [ [ "species_10455842", "catalyst" ] ], "additional_components": [ "Q9VUH5", "FBgn0036447", "Q9VUH4", "FBgn0036446" ] }, "reaction_10455826": { "compartment": "compartment_20699", "id": "reaction_10455826", "reactome": "R-DME-975902", "name": "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975925", "species_975910" ], "products": [ "species_981615" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "FBgn0035050" ] }, "reaction_10440190": { "compartment": "compartment_984", "id": "reaction_10440190", "reactome": "R-DME-192417", "name": "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171076" ], "products": [ "species_171149", "species_174602" ], "modifiers": [ [ "species_10440187", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "Q9W1B3", "FBgn0034972", "Q7KT70", "FBgn0001987", "Q9VIC7", "FBgn0051146" ] }, "reaction_10440195": { "compartment": "compartment_984", "id": "reaction_10440195", "reactome": "R-DME-192430", "name": "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10440187", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "Q9W1B3", "FBgn0034972", "Q7KT70", "FBgn0001987", "Q9VIC7", "FBgn0051146" ] }, "reaction_10440193": { "compartment": "compartment_984", "id": "reaction_10440193", "reactome": "R-DME-192425", "name": "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6814795" ], "products": [ "species_174602", "species_192438" ], "modifiers": [ [ "species_10440187", "catalyst" ] ], "additional_components": [ "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q9VIC6", "FBgn0083963", "Q9NGK5", "FBgn0031866", "Q9W1B3", "FBgn0034972", "Q7KT70", "FBgn0001987", "Q9VIC7", "FBgn0051146" ] }, "reaction_10495454": { "compartment": "compartment_984", "id": "reaction_10495454", "reactome": "R-DME-8979996", "name": "LIPs hydrolyze TG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10495451", "catalyst" ] ], "additional_components": [] }, "reaction_10439518": { "compartment": "compartment_984", "id": "reaction_10439518", "reactome": "R-DME-188979", "name": "Digestion of linear starch (amylose) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189075" ], "products": [ "species_191103", "species_188986" ], "modifiers": [ [ "species_10439515", "catalyst" ] ], "additional_components": [ "species_964746", "O18408", "FBgn0020506", "P81641", "FBgn0000078", "P08144", "FBgn0000079" ] }, "reaction_10479867": { "compartment": "compartment_984", "id": "reaction_10479867", "reactome": "R-DME-6786421", "name": "CHIA hydrolyses chitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6786438" ], "products": [ "species_6786426", "species_6786428" ], "modifiers": [ [ "species_10479864", "catalyst" ] ], "additional_components": [ "species_1678743", "FBgn0022702" ] }, "reaction_10439525": { "compartment": "compartment_984", "id": "reaction_10439525", "reactome": "R-DME-189062", "name": "lactose + H2O => D-glucose + D-galactose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188973", "species_109276" ], "products": [ "species_70115", "species_188995" ], "modifiers": [ [ "species_10439522", "catalyst" ] ], "additional_components": [ "Q9VV98", "FBgn0036659" ] }, "reaction_10479907": { "compartment": "compartment_984", "id": "reaction_10479907", "reactome": "R-DME-6786652", "name": "CHIT1 hydrolyses CHIT to 3xADGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_6786654" ], "products": [ "species_6786660" ], "modifiers": [ [ "species_10479904", "catalyst" ] ], "additional_components": [ "Q8T0R7", "FBgn0064237", "Q9W303", "FBgn0026415", "Q8MM24", "FBgn0020416", "Q9VZV2", "FBgn0035398", "Q8MLZ7", "FBgn0020414", "Q9V3D4", "FBgn0020415", "Q23997", "FBgn0013763" ] }, "reaction_10439922": { "compartment": "compartment_984", "id": "reaction_10439922", "reactome": "R-DME-191114", "name": "Digestion of branched starch (amylopectin) by extracellular amylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_189071" ], "products": [ "species_191103", "species_188986", "species_189108" ], "modifiers": [ [ "species_10439515", "catalyst" ] ], "additional_components": [ "species_964746", "O18408", "FBgn0020506", "P81641", "FBgn0000078", "P08144", "FBgn0000079" ] }, "reaction_10491791": { "compartment": "compartment_984", "id": "reaction_10491791", "reactome": "R-DME-8878787", "name": "ALPI dimer hydrolyses phosphate monoesters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8878780" ], "products": [ "species_8878776", "species_109277" ], "modifiers": [ [ "species_10491788", "catalyst" ] ], "additional_components": [ "species_1562550", "species_74016", "Q9VRM9", "FBgn0035620", "Q9VXS8", "FBgn0030661", "Q9W273", "FBgn0034712", "Q9W274", "FBgn0283480", "Q9W275", "FBgn0034710", "M9PD70", "FBgn0283479", "Q24238", "FBgn0016123", "Q7K3X8", "FBgn0033423", "Q9VDG4", "FBgn0038845", "Q9VH28", "FBgn0037786", "Q9VHD0", "FBgn0043791", "Q9VIW9", "FBgn0032779", "Q9VRM8", "FBgn0035619" ] }, "reaction_10477790": { "compartment": "compartment_70101", "id": "reaction_10477790", "reactome": "R-DME-5690827", "name": "TNFAIP3 (A20) ubiquitinates RIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454480", "species_10477782" ], "products": [ "species_10477787" ], "modifiers": [ [ "species_10477782", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734" ] }, "reaction_10477822": { "compartment": "compartment_70101", "id": "reaction_10477822", "reactome": "R-DME-5690870", "name": "OTUD7B,TNFAIP3 deubiquitinate TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477817" ], "products": [ "species_10454480", "species_10477819" ], "modifiers": [ [ "species_10477817", "catalyst" ] ], "additional_components": [ "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VH90", "FBgn0037734", "Q9W3I9", "FBgn0265464", "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734" ] }, "reaction_10479341": { "compartment": "compartment_70101", "id": "reaction_10479341", "reactome": "R-DME-6781953", "name": "YOD1 binds VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479337", "species_10471517" ], "products": [ "species_10479339" ], "modifiers": [], "additional_components": [ "FBgn0035593", "FBgn0286784", "Q7KN62", "FBgn0286784", "Q9VRJ9", "FBgn0035593" ] }, "reaction_10477802": { "compartment": "compartment_70101", "id": "reaction_10477802", "reactome": "R-DME-5690843", "name": "OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477794", "species_10477798" ], "products": [ "species_10477800" ], "modifiers": [], "additional_components": [ "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q8IMZ4", "FBgn0039044", "P48148", "Rho1", "Q9W3I9", "FBgn0265464", "Q06003", "FBgn0004919", "Q8IMZ4", "FBgn0039044", "P48148", "Rho1", "Q9W3I9", "FBgn0265464", "Q9VL00", "FBgn0032214" ] }, "reaction_10479481": { "compartment": "compartment_7660", "id": "reaction_10479481", "reactome": "R-DME-6783238", "name": "OTUB1,(OTUB2) binds TP53, UBE2D1, ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479475", "species_10479477" ], "products": [ "species_10479479" ], "modifiers": [], "additional_components": [ "Q9VL00", "FBgn0032214", "Q8WS79", "FBgn0035849", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q8WS79", "FBgn0035849", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VL00", "FBgn0032214" ] }, "reaction_10490409": { "compartment": "compartment_70101", "id": "reaction_10490409", "reactome": "R-DME-8869506", "name": "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490406" ], "products": [ "species_10437507", "species_10477819" ], "modifiers": [ [ "species_10490406", "catalyst" ] ], "additional_components": [ "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VH90", "FBgn0037734", "Q9W3I9", "FBgn0265464", "Q9W3I9", "FBgn0265464", "Q9VH90", "FBgn0037734" ] }, "reaction_10477810": { "compartment": "compartment_70101", "id": "reaction_10477810", "reactome": "R-DME-5690856", "name": "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477807" ], "products": [ "species_10437507", "species_10477782" ], "modifiers": [ [ "species_10477807", "catalyst" ] ], "additional_components": [ "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734", "P83104", "FBgn0046689", "Q9VH90", "FBgn0037734" ] }, "reaction_10479330": { "compartment": "compartment_70101", "id": "reaction_10479330", "reactome": "R-DME-6781905", "name": "ZRANB1 binds APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477812", "species_10440558" ], "products": [ "species_10479328" ], "modifiers": [], "additional_components": [ "FBgn0037734", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9VH90", "FBgn0037734" ] }, "reaction_209107": { "compartment": "compartment_70101", "id": "reaction_209107", "reactome": "R-DME-209107", "name": "Further phosphorylation of APC by DCO", "reversible": "false", "notes": "Three Serine residues in APC (APC/APC2) are further phosphorylated by DCO. Ser1504, Ser1507 (priming), and Ser1510 in Human APC are further phosphorylated by CKIepsilon.", "reactants": [ "species_113592", "species_206811" ], "products": [ "species_206735", "species_29370" ], "modifiers": [ [ "species_206811", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P18431", "sgg", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209143": { "compartment": "compartment_70101", "id": "reaction_209143", "reactome": "R-DME-209143", "name": "Phosphorylation of AXN and APC by DCO", "reversible": "false", "notes": "Axin (AXN) and APC (APC/APC2) in the 'destruction complex' are primed for phosphorylation by the CKIepsilon orthologue DCO. Ser1505 in Human APC and Ser531 in Human Axin (equivalent to Ser621 in Mouse and Ser529 in Fly) are phosphorylated.", "reactants": [ "species_113592", "species_206741" ], "products": [ "species_29370", "species_206898" ], "modifiers": [ [ "species_206741", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_209082": { "compartment": "compartment_70101", "id": "reaction_209082", "reactome": "R-DME-209082", "name": "Further phosphorylation of APC by SGG", "reversible": "false", "notes": "A Serine in APC (APC/APC2) is further phosphorylated by Shaggy (SGG). Ser1503 in Human APC is phosphorylated by GSK3beta.", "reactants": [ "species_206735", "species_113592" ], "products": [ "species_29370", "species_206602" ], "modifiers": [ [ "species_206735", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P18431", "sgg", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P18431", "sgg", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209049": { "compartment": "compartment_70101", "id": "reaction_209049", "reactome": "R-DME-209049", "name": "Phosphorylation of AXN and APC by SGG", "reversible": "false", "notes": "Additional phosphorylation of the scaffolding molecules, Axin (AXN) and APC (APC/APC2), is carried out by the GSK3beta kinase orthologue Shaggy (SGG) with Ser1501 (also a priming phosphorylation) in Human APC and Ser614 and Thr609 in Mouse Axin (equivalent to Ser522 and Thr517 respectively in Fly and Ser524 and Thr519 in Human).", "reactants": [ "species_113592", "species_206898" ], "products": [ "species_29370", "species_206811" ], "modifiers": [ [ "species_206898", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209109": { "compartment": "compartment_70101", "id": "reaction_209109", "reactome": "R-DME-209109", "name": "Further phosphorylation of ARM by SGG", "reversible": "false", "notes": "Phosphorylation of bound Armadillo (ARM) at Ser44, Ser48, and Thr52 by Shaggy (SGG) occurs.", "reactants": [ "species_113592", "species_206805" ], "products": [ "species_29370", "species_207028" ], "modifiers": [ [ "species_206805", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209134": { "compartment": "compartment_70101", "id": "reaction_209134", "reactome": "R-DME-209134", "name": "Phosphorylation of ARM by CKIalpha", "reversible": "false", "notes": "Armadillo (ARM) is primed for phosphorylation by CKIalpha at Ser56.", "reactants": [ "species_113592", "species_206666" ], "products": [ "species_29370", "species_206805" ], "modifiers": [ [ "species_206666", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209097": { "compartment": "compartment_70101", "id": "reaction_209097", "reactome": "R-DME-209097", "name": "ARM binds to APC and AXN in the 'destruction complex'", "reversible": "false", "notes": "Phosphorylated APC (APC/APC2) and Axin (AXN) are able to bind cytoplasmic Armadillo (ARM) more strongly. This now brings ARM into the 'destruction complex' and within reach of the complexed kinases.", "reactants": [ "species_205774", "species_206602" ], "products": [ "species_206666" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209133": { "compartment": "compartment_70101", "id": "reaction_209133", "reactome": "R-DME-209133", "name": "Formation of the 'destruction complex'", "reversible": "false", "notes": "The 'destruction complex' is formed from the large scaffolding proteins Axin (AXN) and APC (APC/APC2). This enables regulating molecules such as the kinases, CKIalpha, DCO, and Shaggy (SGG) and the phosphatase, PP2A to be held together in close proximity where they can regulate the phosphorylation of the scaffolding molecules and cytoplasmic Armadillo (ARM). The protein serine/threonine phosphatase PP2A is made up of the regulatory subunit A, PP2A-29B; the regulatory subunit B, Twins (TWS); and the catalytic subunit C, Microtubule star (MTS).", "reactants": [ "species_206938", "species_205716", "species_206581", "species_205729", "species_206017", "species_206210" ], "products": [ "species_206741" ], "modifiers": [], "additional_components": [ "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_10436639": { "compartment": "compartment_7660", "id": "reaction_10436639", "reactome": "R-DME-163748", "name": "Transcriptional activation of GP-acyl transferase gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10432514" ], "modifiers": [ [ "species_10436628", "catalyst" ] ], "additional_components": [ "Q7KTI0", "FBgn0026718", "Q9VYJ4", "FBgn0030421", "Q9VID4", "FBgn0032940", "Q9VB47", "FBgn0039509" ] }, "reaction_10436637": { "compartment": "compartment_7660", "id": "reaction_10436637", "reactome": "R-DME-163743", "name": "Transcriptional activation of Acetyl-CoA carboxylase by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10436635" ], "modifiers": [ [ "species_10436628", "catalyst" ] ], "additional_components": [ "FBgn0033246", "Q9VID4", "FBgn0032940", "Q9VB47", "FBgn0039509" ] }, "reaction_10436630": { "compartment": "compartment_7660", "id": "reaction_10436630", "reactome": "R-DME-163733", "name": "Transcriptional activation of FAS monomer gene by ChREBP:MLX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10432485" ], "modifiers": [ [ "species_10436628", "catalyst" ] ], "additional_components": [ "FBgn0283427", "Q9VID4", "FBgn0032940", "Q9VB47", "FBgn0039509" ] }, "reaction_10433767": { "compartment": "compartment_70101", "id": "reaction_10433767", "reactome": "R-DME-109858", "name": "MAP2K2 binds MAPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433763", "species_10433742" ], "products": [ "species_10433765" ], "modifiers": [], "additional_components": [ "FBgn0003256", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10433796": { "compartment": "compartment_70101", "id": "reaction_10433796", "reactome": "R-DME-109864", "name": "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433789" ], "products": [ "species_10433763", "species_10433787" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "FBgn0003256" ] }, "reaction_10428216": { "compartment": "compartment_70101", "id": "reaction_10428216", "reactome": "R-DME-70592", "name": "PXLP-K259-GOT1 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29448" ], "products": [ "species_29404", "species_76213" ], "modifiers": [ [ "species_10428192", "catalyst" ] ], "additional_components": [ "A1ZAA5", "FBgn0001124" ] }, "reaction_10444310": { "compartment": "compartment_70101", "id": "reaction_10444310", "reactome": "R-DME-372448", "name": "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113553" ], "products": [ "species_29448", "species_113552" ], "modifiers": [ [ "species_10444305", "catalyst" ] ], "additional_components": [ "FBgn0028646" ] }, "reaction_10479958": { "compartment": "compartment_70101", "id": "reaction_10479958", "reactome": "R-DME-6787757", "name": "PXLP-K333-GADL1 decarboxylates acidic AAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787759" ], "products": [ "species_113528", "species_6787762" ], "modifiers": [ [ "species_10479955", "catalyst" ] ], "additional_components": [ "species_1614519", "species_113553", "CHEBI:17285", "species_73590", "species_1655445", "CHEBI:15891", "Q9VPH6", "FBgn0036975", "Q24062", "FBgn0000153" ] }, "reaction_10481284": { "compartment": "compartment_70101", "id": "reaction_10481284", "reactome": "R-DME-6797627", "name": "ASPG hydrolyses L-Asn to L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29642" ], "products": [ "species_29448", "species_29382" ], "modifiers": [ [ "species_10481281", "catalyst" ] ], "additional_components": [ "FBgn0029689" ] }, "reaction_10428227": { "compartment": "compartment_5460", "id": "reaction_10428227", "reactome": "R-DME-70596", "name": "GOT2 dimer deaminates L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113553" ], "products": [ "species_113587", "species_113552" ], "modifiers": [ [ "species_10428224", "catalyst" ] ], "additional_components": [ "Q8IPY3", "FBgn0001125" ] }, "reaction_10428195": { "compartment": "compartment_70101", "id": "reaction_10428195", "reactome": "R-DME-70581", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_76213" ], "products": [ "species_29406", "species_29448" ], "modifiers": [ [ "species_10428192", "catalyst" ] ], "additional_components": [ "A1ZAA5", "FBgn0001124" ] }, "reaction_10460687": { "compartment": "compartment_70101", "id": "reaction_10460687", "reactome": "R-DME-1614583", "name": "PXLP-K212-CTH cleaves L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1614518", "species_29356" ], "products": [ "species_111707", "species_29382", "species_936714" ], "modifiers": [ [ "species_10460681", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460661": { "compartment": "compartment_70101", "id": "reaction_10460661", "reactome": "R-DME-1614524", "name": "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_174369" ], "products": [ "species_1614518", "species_29356" ], "modifiers": [ [ "species_10460658", "catalyst" ] ], "additional_components": [ "species_71185", "Q9VRD9", "FBgn0031148" ] }, "reaction_10498480": { "compartment": "compartment_70101", "id": "reaction_10498480", "reactome": "R-DME-9679028", "name": "JAK3 binds JAK3 inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678772", "species_10453150" ], "products": [ "species_10498478" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop" ] }, "reaction_10480006": { "compartment": "compartment_70101", "id": "reaction_10480006", "reactome": "R-DME-6788623", "name": "p-Y-STATs translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480000" ], "products": [ "species_10480004" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10479859": { "compartment": "compartment_70101", "id": "reaction_10479859", "reactome": "R-DME-6786293", "name": "p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479790" ], "products": [ "species_10479857" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10480307": { "compartment": "compartment_17957", "id": "reaction_10480307", "reactome": "R-DME-6790038", "name": "Expression of HSP90B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10480305" ], "modifiers": [ [ "species_10457732", "catalyst" ] ], "additional_components": [ "FBgn0039562", "Q24151", "Stat92E" ] }, "reaction_10480002": { "compartment": "compartment_70101", "id": "reaction_10480002", "reactome": "R-DME-6788622", "name": "p-Y-STATs dimerize", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479786" ], "products": [ "species_10480000" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10479792": { "compartment": "compartment_70101", "id": "reaction_10479792", "reactome": "R-DME-6786097", "name": "p-Y705-STAT3, p-Y641-STAT6 dimerise", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718" ], "products": [ "species_10479790" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10498451": { "compartment": "compartment_7660", "id": "reaction_10498451", "reactome": "R-DME-9671145", "name": "DKC1 binds SHQ1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498447", "species_10436122" ], "products": [ "species_10498449" ], "modifiers": [], "additional_components": [ "FBgn0037482", "FBgn0259937", "O44081", "FBgn0259937", "Q9VI74", "FBgn0037482" ] }, "reaction_169827": { "compartment": "compartment_70101", "id": "reaction_169827", "reactome": "R-DME-169827", "name": "DPDK1 phosphorylates and activates DS6K", "reversible": "false", "notes": "DPDK1 is thought to directly phosphorylate a Threonine residue in the activation loop of the p70 DS6K catalytic domain.", "reactants": [ "species_113592", "species_110503" ], "products": [ "species_29370", "species_110505" ], "modifiers": [ [ "species_110528", "catalyst" ] ], "additional_components": [] }, "reaction_110498": { "compartment": "compartment_70101", "id": "reaction_110498", "reactome": "R-DME-110498", "name": "DTOR is positively regulated by DRheb-GTP", "reversible": "false", "notes": "Insulin signaling stimulates cell growth through the conserved protein kinase DTOR (target of rapamycin). DTOR is positively regulated by DRheb-GTP by a mechanism which has yet to be deciphered although a serine residue is thought to be phosphorylated on DTOR.", "reactants": [ "species_110495", "species_113592" ], "products": [ "species_29370", "species_110497" ], "modifiers": [], "additional_components": [] }, "reaction_110485": { "compartment": "compartment_70101", "id": "reaction_110485", "reactome": "R-DME-110485", "name": "DTSC1 AND DTSC2 form a complex", "reversible": "false", "notes": "Tuberous sclerosis is a human disease caused by mutated TSC1 or TSC2 tumor repressor genes. The Drosophila equivalents form a complex and are negative regulators of TOR signaling.", "reactants": [ "species_110482", "species_110480" ], "products": [ "species_110484" ], "modifiers": [], "additional_components": [ "Q9U9A9", "TSC1", "Q9U9B0", "Phospho-DTSC2" ] }, "reaction_165127": { "compartment": "compartment_70101", "id": "reaction_165127", "reactome": "R-DME-165127", "name": "GEF binds to the inactive DRheb", "reversible": "false", "notes": "The interaction of DRheb with its guanine nucleotide exchange factor (GEF) has not been studied experimentally, but is inferred here by analogy to the very well-studied interaction of Ran GTPase with RCC1 (Azuma et al. 1999; Renault et al. 2001). GEF binds reversibly to the DRheb-GDP complex, forming a GEF:GTPase:GDP complex. Complex formation induces a change in the shape of the GTPase, substantially reducing its affinity for bound guanine nucleotide.", "reactants": [ "species_165124", "species_110416" ], "products": [ "species_165123" ], "modifiers": [], "additional_components": [ "species_29420", "Q9VND8", "Rheb", "Q95V18", "GEF", "species_29420", "Q9VND8", "Rheb" ] }, "reaction_169828": { "compartment": "compartment_70101", "id": "reaction_169828", "reactome": "R-DME-169828", "name": "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex", "reversible": "false", "notes": "DTSC2 is inactivated by DAkt1-dependent phosphorylation of residues threonine (1518) and serine (924) which is thought to destabilize DTSC2 and disrupt it's interaction with DTSC1.", "reactants": [ "species_113592", "species_110484" ], "products": [ "species_29370", "species_110480", "species_169826" ], "modifiers": [ [ "species_110466", "catalyst" ] ], "additional_components": [ "Q9U9A9", "TSC1", "Q9U9B0", "Phospho-DTSC2" ] }, "reaction_110518": { "compartment": "compartment_70101", "id": "reaction_110518", "reactome": "R-DME-110518", "name": "Activated DTOR also phosphorylates D4EBP", "reversible": "false", "notes": "DeIF4E is an initiation factor for eukaryotic translation. D4EBP forms a complex with DeIF4E, inactivating the latter. Activated DTOR phosphorylates D4EBP on a threonine residue, causing it to dissociate from DeIF4E.", "reactants": [ "species_113592", "species_110512" ], "products": [ "species_110511", "species_29370", "species_110517" ], "modifiers": [ [ "species_110497", "catalyst" ] ], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1" ] }, "reaction_165131": { "compartment": "compartment_70101", "id": "reaction_165131", "reactome": "R-DME-165131", "name": "GEF dissociates from DRheb-GTP", "reversible": "false", "notes": "The interaction of DRheb with its guanine nucleotide exchange factor (GEF) has not been studied experimentally, but is inferred here by analogy to the very well-studied interaction of Ran GTPase with RCC1 (Azuma et al. 1999; Renault et al. 2001). The GEF:DRheb-GTP complex dissociates reversibly to GEF + DRheb-GTP. The affinity of GTPase for bound nucleotide returns to its high value, so the nucleotide now stays strongly bound.", "reactants": [ "species_165125" ], "products": [ "species_110415", "species_165124" ], "modifiers": [], "additional_components": [ "Q95V18", "GEF", "species_29438", "Q9VND8", "Rheb", "species_29438", "Q9VND8", "Rheb" ] }, "reaction_110491": { "compartment": "compartment_70101", "id": "reaction_110491", "reactome": "R-DME-110491", "name": "DRheb is inhibited by the TSC1/2 complex", "reversible": "false", "notes": "The DTSC1/2 complex antagonizes the amino-acid-TOR signaling pathway. DTSC1/2 complex has a GTPase-activating protein domain (GAP). DRheb (a small GTPase called Ras homologue enriched in brain) is a target for DTSC2 GAP activity. As DRheb is a downstream effector from DTSC1/2, its inhibition by DTSC1/2 results in growth inhibition.", "reactants": [ "species_110415" ], "products": [ "species_29372", "species_110416" ], "modifiers": [ [ "species_110484", "catalyst" ] ], "additional_components": [ "species_29438", "Q9VND8", "Rheb", "species_29420", "Q9VND8", "Rheb", "Q9U9A9", "TSC1", "Q9U9B0", "Phospho-DTSC2" ] }, "reaction_165129": { "compartment": "compartment_70101", "id": "reaction_165129", "reactome": "R-DME-165129", "name": "GDP is exchanged for GTP on DRheb", "reversible": "false", "notes": "The GEF:DRheb-GDP complex freely exchanges its bound nucleotide for free nucleotide from the cytosol. Normally, the concentration of cytosolic GTP is about ten times greater than the concentration of GDP, so under physiological conditions, this exchange event favors formation of DRheb-GTP.", "reactants": [ "species_29438", "species_165123" ], "products": [ "species_29420", "species_165125" ], "modifiers": [ [ "species_165123", "catalyst" ] ], "additional_components": [ "Q95V18", "GEF", "species_29420", "Q9VND8", "Rheb", "Q95V18", "GEF", "species_29438", "Q9VND8", "Rheb", "Q95V18", "GEF", "species_29420", "Q9VND8", "Rheb" ] }, "reaction_110506": { "compartment": "compartment_70101", "id": "reaction_110506", "reactome": "R-DME-110506", "name": "Activated DTOR phosphorylates DS6K", "reversible": "false", "notes": "DTOR phosphorylates a threonine residue on DS6K, which is an important effector of cell growth.", "reactants": [ "species_113592", "species_110503" ], "products": [ "species_29370", "species_110505" ], "modifiers": [ [ "species_110497", "catalyst" ] ], "additional_components": [] }, "reaction_110437": { "compartment": "compartment_984", "id": "reaction_110437", "reactome": "R-DME-110437", "name": "DILP binds to Drosophila insulin receptor (DINR)", "reversible": "false", "notes": "Drosophila contains seven insulin-like genes which encode for DILP (Drosophila Insulin-like peptide)1-7. These DILPs can bind to the Drosophila Insulin receptor (DINR) to initiate intracellular signaling.", "reactants": [ "species_110422", "species_164721" ], "products": [ "species_110427" ], "modifiers": [], "additional_components": [ "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR" ] }, "reaction_110453": { "compartment": "compartment_70101", "id": "reaction_110453", "reactome": "R-DME-110453", "name": "Phosphorylation of PIP2 to PIP3 by Dp110", "reversible": "false", "notes": "PI3Ks are implicated in cell growth, number and size. Dp110, the Drosophila PI3K, phosphorylates PIP2 -> PIP3 (both intracellular messengers) to continue the signaling mechanism. Overexpression of Dp110 results in enlarged cell size and number suggesting a role for Dp110 in growth and size control.", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_29370", "species_38117" ], "modifiers": [ [ "species_110435", "catalyst" ] ], "additional_components": [ "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "O18683", "PI3K21B", "P91634", "Pi3K92E" ] }, "reaction_110468": { "compartment": "compartment_70101", "id": "reaction_110468", "reactome": "R-DME-110468", "name": "Activation of DAkt1 by DPDK1", "reversible": "false", "notes": "DPDK1 (a phosphoinositide-dependant protein kinase) controls cellular and organism growth through two effector pathways by activating DAkt and DS6K (S6 kinase). Phosphorylation of the residues Thr308 and Ser473 by DPDK1 (and another downstream kinase?) relieves intermolecular inhibition, allowing the activated DAkt to dissociate from PIP3 and modify its target, DFOXO.", "reactants": [ "species_113592", "species_110452" ], "products": [ "species_29370", "species_38117", "species_110466" ], "modifiers": [ [ "species_110528", "catalyst" ] ], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_110440": { "compartment": "compartment_70101", "id": "reaction_110440", "reactome": "R-DME-110440", "name": "Autophosphorylation of DINR", "reversible": "false", "notes": "Binding of a DILP to DINR induces a conformational change leading to autophosphorylation.", "reactants": [ "species_110427", "species_113592" ], "products": [ "species_110426", "species_29370" ], "modifiers": [ [ "species_110427", "catalyst" ] ], "additional_components": [ "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR" ] }, "reaction_164696": { "compartment": "compartment_70101", "id": "reaction_164696", "reactome": "R-DME-164696", "name": "Chico is phosphorylated", "reversible": "false", "notes": "The beta subunit of the DINR complex binds and phosphorylates Chico. Chico has 3 phosphotyrosine binding domains on residues 411, 911 and 948 where it can be phosphorylated. The tyrosine kinase function of DINR phosphorylates Chico on these domains. Phosphorylated Chico binds to SH2 domain-containing proteins such as PI3K (Phosphoinositide 3-Kinase).", "reactants": [ "species_110430", "species_113592" ], "products": [ "species_29370", "species_164707" ], "modifiers": [ [ "species_110430", "catalyst" ] ], "additional_components": [ "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico", "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico" ] }, "reaction_110459": { "compartment": "compartment_70101", "id": "reaction_110459", "reactome": "R-DME-110459", "name": "PIP3 dephosphorylated to PIP2 by DPTEN", "reversible": "false", "notes": "DPTEN (a phosphoinositide phosphatase) catalyses the reversal of PIP3 to PIP2. This mechanism, together with Dp110 activity, regulates the levels of PIP3 which is the second messenger for controlling organism size.", "reactants": [ "species_38117" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_110456", "catalyst" ] ], "additional_components": [] }, "reaction_110475": { "compartment": "compartment_70101", "id": "reaction_110475", "reactome": "R-DME-110475", "name": "DAkt1-mediated phosphorylation inactivates DFOXO", "reversible": "false", "notes": "DFOXO belongs to the FOXO subfamily of forkhead transcription factors. The FOXO factors regulate genes involved in cell cycle control, cell death and stress responses. Phosphorylation of DFOXO by DAkt1 on three residues (Thr44, Ser190 and Ser259) leads to its cytoplasmic retention and inactivation, inhibiting expression of DFOXO-regulated genes. These include D4EBP, DInR and Chico.", "reactants": [ "species_113592", "species_110472" ], "products": [ "species_110474", "species_29370" ], "modifiers": [ [ "species_110466", "catalyst" ] ], "additional_components": [] }, "reaction_110442": { "compartment": "compartment_70101", "id": "reaction_110442", "reactome": "R-DME-110442", "name": "Activated DINR binds Chico", "reversible": "false", "notes": "The Drosophila homologue to mammalian IRS1-4 (Insulin Receptor Substrate), Chico, binds to the beta subunit of DINR. Chico is an adaptor protein that interacts with the activated drosophila insulin-like receptor (DINR), allowing signaling molecules to attach and signal to downstream effectors.", "reactants": [ "species_110429", "species_110426" ], "products": [ "species_110430" ], "modifiers": [], "additional_components": [ "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico" ] }, "reaction_110463": { "compartment": "compartment_70101", "id": "reaction_110463", "reactome": "R-DME-110463", "name": "Increased PIP3 levels recruit DAkt1 to the membrane", "reversible": "false", "notes": "DAkt (a protein kinase B) is recruited to the plasma membrane due to the interaction between its PH (pleckstrin homology) domain and PIP3. In Drosophila, DAkt appears to be the only target activated by increased PIP3 levels.", "reactants": [ "species_110462", "species_38117" ], "products": [ "species_110452" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_110446": { "compartment": "compartment_70101", "id": "reaction_110446", "reactome": "R-DME-110446", "name": "Phospho-Chico: Activated DINR binds p60:Dp110", "reversible": "false", "notes": "The Phospho-Chico: Activated DINR in the plasma membrane binds to cytosolic p60:p110. The p60 subunit of the latter complex mediates this interaction; the p110 subunit is the Drosophila PI3K. This complex is an active protein kinase whose direct and indirect targets include PIP2, annotated here.", "reactants": [ "species_110434", "species_164707" ], "products": [ "species_110435" ], "modifiers": [], "additional_components": [ "O18683", "PI3K21B", "P91634", "Pi3K92E", "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "Q9XTN2", "chico", "Q9VT51", "ILP2 alpha chain", "Q9VT53", "ILP4 alpha chain", "Q9VT52", "ILP3 alpha chain", "Q7KUD5", "ILP5 alpha chain", "Q9W4Q9", "ILP7 alpha chain", "Q9VT50", "ILP1 alpha chain", "Q9W4Z4", "ILP6 alpha chain", "P09208", "InR", "O18683", "PI3K21B", "P91634", "Pi3K92E" ] }, "reaction_10461117": { "compartment": "compartment_172574", "id": "reaction_10461117", "reactome": "R-DME-1676024", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806195" ], "products": [ "species_1806198", "species_29370" ], "modifiers": [ [ "species_10461070", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099", "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10461137": { "compartment": "compartment_172574", "id": "reaction_10461137", "reactome": "R-DME-1676065", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806289" ], "products": [ "species_1806212", "species_29372" ], "modifiers": [ [ "species_10461006", "catalyst" ] ], "additional_components": [ "Q8MLR7", "FBgn0028497", "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10461009": { "compartment": "compartment_172574", "id": "reaction_10461009", "reactome": "R-DME-1675795", "name": "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806198", "species_29356" ], "products": [ "species_29372", "species_1806195" ], "modifiers": [ [ "species_10461006", "catalyst" ] ], "additional_components": [ "Q8MLR7", "FBgn0028497", "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10445980": { "compartment": "compartment_12045", "id": "reaction_10445980", "reactome": "R-DME-381186", "name": "ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445976" ], "products": [ "species_10445962" ], "modifiers": [], "additional_components": [ "FBgn0033010", "FBgn0033010" ] }, "reaction_10445916": { "compartment": "compartment_70101", "id": "reaction_10445916", "reactome": "R-DME-381026", "name": "ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445912" ], "products": [ "species_10445914" ], "modifiers": [], "additional_components": [ "FBgn0033010", "FBgn0033010" ] }, "reaction_10447719": { "compartment": "compartment_20699", "id": "reaction_10447719", "reactome": "R-DME-420818", "name": "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445964" ], "products": [ "species_10445912", "species_10447711" ], "modifiers": [ [ "species_10447716", "catalyst" ] ], "additional_components": [ "FBgn0033010", "FBgn0033010", "FBgn0033010", "FBgn0033656" ] }, "reaction_10445974": { "compartment": "compartment_20699", "id": "reaction_10445974", "reactome": "R-DME-381135", "name": "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445962" ], "products": [ "species_10445964", "species_10445966" ], "modifiers": [ [ "species_10445971", "catalyst" ] ], "additional_components": [ "FBgn0033010", "FBgn0033010", "FBgn0033010", "FBgn0037105" ] }, "reaction_209303": { "compartment": "compartment_13231", "id": "reaction_209303", "reactome": "R-DME-209303", "name": "LGS transports from the nucleus to the cytosol", "reversible": "false", "notes": "The free Legless (LGS) protein exports from the nucleus to the cytoplasm by an unknown mechanism potentially with additional interaction partners, where it can now target Armadillo (ARM), which is now not being rapidly removed from the cytoplasm by the 'destruction complex'.", "reactants": [ "species_205826" ], "products": [ "species_205724" ], "modifiers": [], "additional_components": [] }, "reaction_209332": { "compartment": "compartment_7660", "id": "reaction_209332", "reactome": "R-DME-209332", "name": "LGS dissociates from the PYGO complex", "reversible": "false", "notes": "The inactivation and destabilisation of the 'destruction complex' means elevated levels of cytoplasmic Armadillo (ARM). In the nucleus, the protein Legless (LGS) dissociates from its nuclear anchor, Pygopus (PYGO).", "reactants": [ "species_206853" ], "products": [ "species_205990", "species_205826" ], "modifiers": [], "additional_components": [ "Q961D9", "LGS", "Q9V9W8", "PYGO" ] }, "reaction_209371": { "compartment": "compartment_70101", "id": "reaction_209371", "reactome": "R-DME-209371", "name": "LGS binds to ARM", "reversible": "false", "notes": "The targeted free cytoplasmic Armadillo (ARM) is complexed to Legless (LGS).", "reactants": [ "species_205724", "species_205774" ], "products": [ "species_206796" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q961D9", "LGS" ] }, "reaction_209177": { "compartment": "compartment_13231", "id": "reaction_209177", "reactome": "R-DME-209177", "name": "LGS:ARM complex transports from the cytosol to the nucleus", "reversible": "false", "notes": "The Legless:Armadillo (LGS:ARM) complex is imported to the nucleus by an unknown mechanism which may include additional interaction partners.", "reactants": [ "species_206796" ], "products": [ "species_206839" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q961D9", "LGS", "Q961D9", "LGS", "P18824", "arm" ] }, "reaction_10461167": { "compartment": "compartment_12045", "id": "reaction_10461167", "reactome": "R-DME-1676124", "name": "PI4P is dephosphorylated to PI by SACM1L at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806234" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10461164", "catalyst" ] ], "additional_components": [ "FBgn0283500" ] }, "reaction_10461022": { "compartment": "compartment_12045", "id": "reaction_10461022", "reactome": "R-DME-1675813", "name": "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_1806234" ], "modifiers": [ [ "species_10461019", "catalyst" ] ], "additional_components": [ "M9PDM4", "FBgn0267350", "Q9VND3", "FBgn0037339" ] }, "reaction_10486803": { "compartment": "compartment_70101", "id": "reaction_10486803", "reactome": "R-DME-6809764", "name": "SBF1 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486799", "species_10460994" ], "products": [ "species_10486801" ], "modifiers": [], "additional_components": [ "FBgn0025802", "FBgn0025742", "Q9VMI9", "FBgn0025742", "Q9VGH9", "FBgn0025802" ] }, "reaction_10486806": { "compartment": "compartment_70101", "id": "reaction_10486806", "reactome": "R-DME-6809777", "name": "PI3P is dephosphorylated to PI by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5676030" ], "products": [ "species_29372", "species_426639" ], "modifiers": [ [ "species_10486801", "catalyst" ] ], "additional_components": [ "Q9VMI9", "FBgn0025742", "Q9VGH9", "FBgn0025802" ] }, "reaction_10486809": { "compartment": "compartment_70101", "id": "reaction_10486809", "reactome": "R-DME-6809778", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6809774" ], "products": [ "species_29372", "species_422529" ], "modifiers": [ [ "species_10486801", "catalyst" ] ], "additional_components": [ "Q9VMI9", "FBgn0025742", "Q9VGH9", "FBgn0025802" ] }, "reaction_10486896": { "compartment": "compartment_172574", "id": "reaction_10486896", "reactome": "R-DME-6810392", "name": "TMEM55B translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486892" ], "products": [ "species_10486894" ], "modifiers": [], "additional_components": [ "FBgn0036058", "FBgn0036058" ] }, "reaction_10486899": { "compartment": "compartment_7660", "id": "reaction_10486899", "reactome": "R-DME-6810410", "name": "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_6810412" ], "products": [ "species_6810408", "species_113550" ], "modifiers": [ [ "species_10486894", "catalyst" ] ], "additional_components": [ "FBgn0036058" ] }, "reaction_10487163": { "compartment": "compartment_7660", "id": "reaction_10487163", "reactome": "R-DME-6811522", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_29358" ], "products": [ "species_113582", "species_6810412" ], "modifiers": [ [ "species_10487160", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924" ] }, "reaction_10461051": { "compartment": "compartment_20699", "id": "reaction_10461051", "reactome": "R-DME-1675883", "name": "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10461048", "catalyst" ] ], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "A0A4D6K881", "FBgn0004373" ] }, "reaction_10461210": { "compartment": "compartment_20699", "id": "reaction_10461210", "reactome": "R-DME-1676185", "name": "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806217" ], "modifiers": [ [ "species_10461207", "catalyst" ] ], "additional_components": [ "M9PDM4", "FBgn0267350", "Q9VND3", "FBgn0037339" ] }, "reaction_10461162": { "compartment": "compartment_20699", "id": "reaction_10461162", "reactome": "R-DME-1676114", "name": "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806159" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10461159", "catalyst" ] ], "additional_components": [ "FBgn0283500" ] }, "reaction_10461094": { "compartment": "compartment_20699", "id": "reaction_10461094", "reactome": "R-DME-1675961", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1524146" ], "products": [ "species_29370", "species_1806159" ], "modifiers": [ [ "species_10461070", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099", "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10461062": { "compartment": "compartment_20699", "id": "reaction_10461062", "reactome": "R-DME-1675928", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1806217" ], "products": [ "species_1806230", "species_29370" ], "modifiers": [ [ "species_10461059", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926" ] }, "reaction_10461188": { "compartment": "compartment_20699", "id": "reaction_10461188", "reactome": "R-DME-1676152", "name": "PI4KB binds to ARF1/3:GTP at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461186", "species_10461046" ], "products": [ "species_10461048" ], "modifiers": [], "additional_components": [ "FBgn0004373", "P61209", "FBgn0010348", "species_29438", "P61209", "FBgn0010348", "species_29438", "A0A4D6K881", "FBgn0004373" ] }, "reaction_10461027": { "compartment": "compartment_20699", "id": "reaction_10461027", "reactome": "R-DME-1675824", "name": "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806165", "species_29356" ], "products": [ "species_29372", "species_1806217" ], "modifiers": [ [ "species_10461024", "catalyst" ] ], "additional_components": [ "FBgn0023508" ] }, "reaction_10461170": { "compartment": "compartment_20699", "id": "reaction_10461170", "reactome": "R-DME-1676133", "name": "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806217" ], "products": [ "species_29372", "species_1524146" ], "modifiers": [ [ "species_10461159", "catalyst" ] ], "additional_components": [ "FBgn0283500" ] }, "reaction_10490964": { "compartment": "compartment_437051", "id": "reaction_10490964", "reactome": "R-DME-8874470", "name": "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8874484" ], "products": [ "species_8874460" ], "modifiers": [ [ "species_10490961", "catalyst" ] ], "additional_components": [ "species_179838", "species_179856", "species_179856", "species_179838", "Q7KVH9", "FBgn0034894" ] }, "reaction_10461198": { "compartment": "compartment_171062", "id": "reaction_10461198", "reactome": "R-DME-1676162", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806238" ], "products": [ "species_29372", "species_1806200" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10486787": { "compartment": "compartment_70101", "id": "reaction_10486787", "reactome": "R-DME-6809680", "name": "MTMR12 binds MTM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486783", "species_10460992" ], "products": [ "species_10486785" ], "modifiers": [], "additional_components": [ "FBgn0030582", "FBgn0025742", "Q9VMI9", "FBgn0025742", "Q9VY15", "FBgn0030582" ] }, "reaction_10461145": { "compartment": "compartment_171062", "id": "reaction_10461145", "reactome": "R-DME-1676105", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806205" ], "products": [ "species_29372", "species_1806259" ], "modifiers": [ [ "species_10461142", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10461176": { "compartment": "compartment_171062", "id": "reaction_10461176", "reactome": "R-DME-1676141", "name": "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10461142", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q9VMI9", "FBgn0025742" ] }, "reaction_10486791": { "compartment": "compartment_70101", "id": "reaction_10486791", "reactome": "R-DME-6809707", "name": "MTMR12 binds MTMR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486783", "species_10460994" ], "products": [ "species_10486789" ], "modifiers": [], "additional_components": [ "FBgn0030582", "FBgn0025742", "Q9VMI9", "FBgn0025742", "Q9VY15", "FBgn0030582" ] }, "reaction_10461096": { "compartment": "compartment_171062", "id": "reaction_10461096", "reactome": "R-DME-1675974", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_1806180", "species_29370" ], "modifiers": [ [ "species_10460982", "catalyst" ] ], "additional_components": [ "FBgn0037339" ] }, "reaction_10488313": { "compartment": "compartment_70101", "id": "reaction_10488313", "reactome": "R-DME-8849969", "name": "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8849959" ], "products": [ "species_29372", "species_8849958" ], "modifiers": [ [ "species_10488310", "catalyst" ] ], "additional_components": [ "species_179838", "species_202247", "species_179856", "species_1806198", "species_1806289", "species_1806212", "FBgn0038890" ] }, "reaction_10486794": { "compartment": "compartment_171062", "id": "reaction_10486794", "reactome": "R-DME-6809720", "name": "PI3P is dephosphorylated to PI by MTM1:MTMR12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806200" ], "products": [ "species_29372", "species_1806199" ], "modifiers": [ [ "species_10486785", "catalyst" ] ], "additional_components": [ "Q9VMI9", "FBgn0025742", "Q9VY15", "FBgn0030582" ] }, "reaction_10461073": { "compartment": "compartment_171062", "id": "reaction_10461073", "reactome": "R-DME-1675939", "name": "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806199", "species_113592" ], "products": [ "species_29370", "species_1806200" ], "modifiers": [ [ "species_10461070", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099", "Q9VHH2", "FBgn0260935", "Q9W1M7", "FBgn0015277" ] }, "reaction_10461216": { "compartment": "compartment_171062", "id": "reaction_10461216", "reactome": "R-DME-1676206", "name": "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806180", "species_113592" ], "products": [ "species_29370", "species_1806238" ], "modifiers": [ [ "species_10461055", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "species_74016", "species_29926" ] }, "reaction_10487317": { "compartment": "compartment_12045", "id": "reaction_10487317", "reactome": "R-DME-6814254", "name": "PNPLA6 hydrolyzes LysoPtdCho", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6814253" ], "products": [ "species_1498750", "species_1524021" ], "modifiers": [ [ "species_10487314", "catalyst" ] ], "additional_components": [ "FBgn0003656" ] }, "reaction_10487177": { "compartment": "compartment_876", "id": "reaction_10487177", "reactome": "R-DME-6813740", "name": "GDE1 hydrolyzes GroPIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6813734" ], "products": [ "species_426910", "species_76114" ], "modifiers": [ [ "species_10487174", "catalyst" ] ], "additional_components": [ "FBgn0038432" ] }, "reaction_10441150": { "compartment": "compartment_70101", "id": "reaction_10441150", "reactome": "R-DME-199456", "name": "PTEN dephosphorylates PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_179856" ], "modifiers": [ [ "species_10441147", "catalyst" ] ], "additional_components": [] }, "reaction_10461181": { "compartment": "compartment_876", "id": "reaction_10461181", "reactome": "R-DME-1676145", "name": "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10461178", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924", "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461213": { "compartment": "compartment_876", "id": "reaction_10461213", "reactome": "R-DME-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10461112", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q5U0V7", "FBgn0034691", "A1ZAS8", "FBgn0027506", "Q8MLR7", "FBgn0028497", "Q9VMI9", "FBgn0025742" ] }, "reaction_10461115": { "compartment": "compartment_876", "id": "reaction_10461115", "reactome": "R-DME-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10461112", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "Q5U0V7", "FBgn0034691", "A1ZAS8", "FBgn0027506", "Q8MLR7", "FBgn0028497", "Q9VMI9", "FBgn0025742" ] }, "reaction_10460987": { "compartment": "compartment_876", "id": "reaction_10460987", "reactome": "R-DME-1675780", "name": "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_29370", "species_392417" ], "modifiers": [ [ "species_10460982", "catalyst" ] ], "additional_components": [ "FBgn0037339" ] }, "reaction_10460951": { "compartment": "compartment_876", "id": "reaction_10460951", "reactome": "R-DME-1675773", "name": "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_202247" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461205": { "compartment": "compartment_876", "id": "reaction_10461205", "reactome": "R-DME-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10461202", "catalyst" ] ], "additional_components": [ "Q5U0V7", "FBgn0034691", "M9PHS8", "FBgn0030761", "Q7K161", "FBgn0034179" ] }, "reaction_10461173": { "compartment": "compartment_876", "id": "reaction_10461173", "reactome": "R-DME-1676134", "name": "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_113592" ], "products": [ "species_1806224", "species_29370" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461140": { "compartment": "compartment_876", "id": "reaction_10461140", "reactome": "R-DME-1676082", "name": "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10461012": { "compartment": "compartment_876", "id": "reaction_10461012", "reactome": "R-DME-1675810", "name": "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426658" ], "products": [ "species_1806240", "species_29370" ], "modifiers": [ [ "species_10460948", "catalyst" ] ], "additional_components": [ "Q0E8Y1", "FBgn0034789", "Q9W2R3", "FBgn0016984" ] }, "reaction_10486766": { "compartment": "compartment_70101", "id": "reaction_10486766", "reactome": "R-DME-6809254", "name": "MTMR8 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486762", "species_10486757" ], "products": [ "species_10486764" ], "modifiers": [], "additional_components": [ "FBgn0035945", "FBgn0028497", "Q8MLR7", "FBgn0028497", "Q8SZY7", "FBgn0035945" ] }, "reaction_10460977": { "compartment": "compartment_876", "id": "reaction_10460977", "reactome": "R-DME-1675776", "name": "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806240", "species_113592" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10460974", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924" ] }, "reaction_10461200": { "compartment": "compartment_876", "id": "reaction_10461200", "reactome": "R-DME-1676164", "name": "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10461039": { "compartment": "compartment_876", "id": "reaction_10461039", "reactome": "R-DME-1675836", "name": "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_1806276", "species_29372" ], "modifiers": [ [ "species_10461036", "catalyst" ] ], "additional_components": [ "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10461134": { "compartment": "compartment_876", "id": "reaction_10461134", "reactome": "R-DME-1676048", "name": "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10461131", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10486770": { "compartment": "compartment_70101", "id": "reaction_10486770", "reactome": "R-DME-6809309", "name": "MTMR6 binds MTMR9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461105", "species_10486762" ], "products": [ "species_10486768" ], "modifiers": [], "additional_components": [ "FBgn0028497", "FBgn0035945", "Q8SZY7", "FBgn0035945", "Q8MLR7", "FBgn0028497" ] }, "reaction_10461099": { "compartment": "compartment_876", "id": "reaction_10461099", "reactome": "R-DME-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_392417" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10461036", "catalyst" ] ], "additional_components": [ "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10490903": { "compartment": "compartment_20699", "id": "reaction_10490903", "reactome": "R-DME-8870499", "name": "PLEKHA3,8 bind PI4P, ARF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444044", "species_10490899", "species_1806217" ], "products": [ "species_10490901" ], "modifiers": [], "additional_components": [ "FBgn0010348", "FBgn0030641", "species_392417", "Q9VXV1", "FBgn0030641", "P61209", "FBgn0010348" ] }, "reaction_10486775": { "compartment": "compartment_876", "id": "reaction_10486775", "reactome": "R-DME-6809320", "name": "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1806224" ], "products": [ "species_29372", "species_1806240" ], "modifiers": [ [ "species_10486772", "catalyst" ] ], "additional_components": [ "Q8SZY7", "FBgn0035945", "Q8MLR7", "FBgn0028497" ] }, "reaction_10486778": { "compartment": "compartment_876", "id": "reaction_10486778", "reactome": "R-DME-6809325", "name": "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1806276", "species_29356" ], "products": [ "species_29372", "species_426658" ], "modifiers": [ [ "species_10486772", "catalyst" ] ], "additional_components": [ "Q8SZY7", "FBgn0035945", "Q8MLR7", "FBgn0028497" ] }, "reaction_10461092": { "compartment": "compartment_876", "id": "reaction_10461092", "reactome": "R-DME-1675949", "name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179838" ], "products": [ "species_29372", "species_202247" ], "modifiers": [ [ "species_10461089", "catalyst" ] ], "additional_components": [ "M9PHS8", "FBgn0030761", "Q7K161", "FBgn0034179" ] }, "reaction_10461154": { "compartment": "compartment_876", "id": "reaction_10461154", "reactome": "R-DME-1676109", "name": "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10461151", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q7K3H0", "FBgn0015278", "species_74016", "species_29926", "species_266099" ] }, "reaction_10461184": { "compartment": "compartment_876", "id": "reaction_10461184", "reactome": "R-DME-1676149", "name": "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_202247" ], "products": [ "species_29372", "species_392417" ], "modifiers": [ [ "species_10441147", "catalyst" ] ], "additional_components": [] }, "reaction_10446383": { "compartment": "compartment_876", "id": "reaction_10446383", "reactome": "R-DME-383190", "name": "HCO3- transport through ion channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592" ], "products": [ "species_29372", "species_29370", "species_425425" ], "modifiers": [ [ "species_10446380", "catalyst" ] ], "additional_components": [ "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793" ] }, "reaction_10471103": { "compartment": "compartment_70101", "id": "reaction_10471103", "reactome": "R-DME-5227009", "name": "ABCF1 binds EIF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430457", "species_10471099" ], "products": [ "species_10471101" ], "modifiers": [], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "FBgn0030321", "Q9VYW4", "FBgn0030321", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926" ] }, "reaction_10487844": { "compartment": "compartment_70101", "id": "reaction_10487844", "reactome": "R-DME-8848053", "name": "ABCA5 transports CHOL from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_8848047" ], "products": [ "species_29372", "species_176478", "species_29370" ], "modifiers": [ [ "species_10487841", "catalyst" ] ], "additional_components": [ "FBgn0263747" ] }, "reaction_10446297": { "compartment": "compartment_17947", "id": "reaction_10446297", "reactome": "R-DME-382575", "name": "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_382577" ], "products": [ "species_382571", "species_29372", "species_29370" ], "modifiers": [ [ "species_10446294", "catalyst" ] ], "additional_components": [ "Q7JUN3", "FBgn0039890", "Q9VWC8", "FBgn0031069" ] }, "reaction_10446328": { "compartment": "compartment_17947", "id": "reaction_10446328", "reactome": "R-DME-382613", "name": "PEX-19 docks ABCD1/D2/D3 to peroximal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446326", "species_10446302" ], "products": [ "species_10446324", "species_10446294", "species_10446302" ], "modifiers": [], "additional_components": [ "Q9VWC8", "FBgn0031069", "Q7JUN3", "FBgn0039890", "Q8IP97", "FBgn0032407", "FBgn0036484", "FBgn0032407", "Q7JUN3", "FBgn0039890", "Q9VWC8", "FBgn0031069", "FBgn0036484" ] }, "reaction_10459304": { "compartment": "compartment_70101", "id": "reaction_10459304", "reactome": "R-DME-1454928", "name": "ABCG4 may mediate cholesterol efflux", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_29356", "species_113592" ], "products": [ "species_171149", "species_29372", "species_29370" ], "modifiers": [ [ "species_10459301", "catalyst" ] ], "additional_components": [ "Q9VQY4", "FBgn0020762" ] }, "reaction_10443719": { "compartment": "compartment_876", "id": "reaction_10443719", "reactome": "R-DME-265783", "name": "ABCG5:ABCG8 transports sterols from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265784", "species_113592" ], "products": [ "species_29372", "species_29370", "species_265781" ], "modifiers": [ [ "species_10443716", "catalyst" ] ], "additional_components": [ "CHEBI:26125", "species_8848047", "CHEBI:26125", "species_8848047", "P45843", "FBgn0003515", "P12428", "FBgn0000241", "Q0KI14", "FBgn0051121", "Q8MRJ2", "FBgn0039244" ] }, "reaction_10443895": { "compartment": "compartment_876", "id": "reaction_10443895", "reactome": "R-DME-266082", "name": "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_216762", "species_113592" ], "products": [ "species_29372", "species_29370", "species_171095" ], "modifiers": [ [ "species_10443892", "catalyst" ] ], "additional_components": [ "Q0E8U2", "FBgn0031515", "Q8T9E6", "FBgn0264494", "Q9VQY4", "FBgn0020762", "M9PBX3", "FBgn0031449", "Q8MRL3", "FBgn0031516", "Q9VPJ7", "FBgn0031220", "Q8IPV3", "FBgn0025683", "Q9VL61", "FBgn0032167", "Q9VTL3", "FBgn0052091" ] }, "reaction_10476387": { "compartment": "compartment_2133233", "id": "reaction_10476387", "reactome": "R-DME-5683714", "name": "ABCA3 transports PC, PG from ER membrane to lamellar body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5684863" ], "products": [ "species_29372", "species_29370", "species_5684869" ], "modifiers": [ [ "species_10476384", "catalyst" ] ], "additional_components": [ "species_429802", "species_8954401", "species_429802", "species_8954401", "FBgn0031170" ] }, "reaction_10459119": { "compartment": "compartment_17906", "id": "reaction_10459119", "reactome": "R-DME-1369065", "name": "ABCB6 transports porphyrin from cytosol to mitchondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1369066", "species_29356", "species_113592" ], "products": [ "species_29372", "species_29370", "species_1369027" ], "modifiers": [ [ "species_10459116", "catalyst" ] ], "additional_components": [ "Q9VF20", "FBgn0038376" ] }, "reaction_10446272": { "compartment": "compartment_70616", "id": "reaction_10446272", "reactome": "R-DME-382560", "name": "ABC7, mABC1 and mABC2 mediate heme transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_189444", "species_113521" ], "products": [ "species_113548", "species_113581", "species_71185" ], "modifiers": [ [ "species_10446269", "catalyst" ] ], "additional_components": [ "Q9W0C5", "FBgn0035244" ] }, "reaction_10476235": { "compartment": "compartment_70101", "id": "reaction_10476235", "reactome": "R-DME-5678863", "name": "CFTR transports Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_352022" ], "products": [ "species_188972", "species_29372", "species_29370" ], "modifiers": [ [ "species_10446380", "catalyst" ] ], "additional_components": [ "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793" ] }, "reaction_10471050": { "compartment": "compartment_70101", "id": "reaction_10471050", "reactome": "R-DME-5223317", "name": "ABCB9 transports peptides from cytosol to lysosomal lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5223341" ], "products": [ "species_5223344", "species_29372", "species_29370" ], "modifiers": [ [ "species_10471047", "catalyst" ] ], "additional_components": [ "Q5BI62", "FBgn0010241" ] }, "reaction_10490055": { "compartment": "compartment_876", "id": "reaction_10490055", "reactome": "R-DME-8866851", "name": "CFTR transits to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489992" ], "products": [ "species_10446380" ], "modifiers": [], "additional_components": [ "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793" ] }, "reaction_10459319": { "compartment": "compartment_876", "id": "reaction_10459319", "reactome": "R-DME-1467457", "name": "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1131652" ], "products": [ "species_29372", "species_29370", "species_1467459" ], "modifiers": [ [ "species_10459316", "catalyst" ] ], "additional_components": [ "Q86B52", "FBgn0263747", "X2JG15", "FBgn0083956" ] }, "reaction_10490041": { "compartment": "compartment_12045", "id": "reaction_10490041", "reactome": "R-DME-8866546", "name": "RNF5 and RNF185 ubiquitinate misfolded CFTR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490038", "species_10426987" ], "products": [ "species_10490036" ], "modifiers": [ [ "species_10490038", "catalyst" ] ], "additional_components": [ "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VKC7", "FBgn0032398", "Q9V415", "FBgn0028475", "Q9VXP1", "FBgn0030693", "Q9VFY3", "FBgn0038125", "Q8IQM1", "FBgn0052847", "Q8IR26", "FBgn0052581", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VKC7", "FBgn0032398", "Q9V415", "FBgn0028475", "Q9VXP1", "FBgn0030693", "Q9VFY3", "FBgn0038125", "Q8IQM1", "FBgn0052847", "Q8IR26", "FBgn0052581", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VKC7", "FBgn0032398", "Q9V415", "FBgn0028475", "Q9VXP1", "FBgn0030693", "Q9VFY3", "FBgn0038125", "Q8IQM1", "FBgn0052847", "Q8IR26", "FBgn0052581", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207" ] }, "reaction_10490043": { "compartment": "compartment_70101", "id": "reaction_10490043", "reactome": "R-DME-8866553", "name": "misfolded CFTR is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489994" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10459297": { "compartment": "compartment_70101", "id": "reaction_10459297", "reactome": "R-DME-1454916", "name": "The ABCC family mediates organic anion transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1454930" ], "products": [ "species_29372", "species_29370", "species_1454919" ], "modifiers": [ [ "species_10459294", "catalyst" ] ], "additional_components": [ "Q9VLN6", "FBgn0032026", "P91660", "FBgn0010549", "Q961D3", "FBgn0039644", "Q9VGM1", "FBgn0263316", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q9VC63", "FBgn0039207", "Q7KT22", "FBgn0032908", "Q9VAN4", "FBgn0039645", "Q9VJ21", "FBgn0051793", "Q9VLP5", "FBgn0032018", "Q9VL32", "FBgn0028675", "Q7KTC0", "FBgn0032456" ] }, "reaction_10463004": { "compartment": "compartment_984", "id": "reaction_10463004", "reactome": "R-DME-2022141", "name": "Prolysyl oxidase activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462952" ], "products": [ "species_10462980", "species_10463002" ], "modifiers": [ [ "species_10462626", "catalyst" ] ], "additional_components": [ "Q9W2C9", "FBgn0034660", "Q9V9X5", "FBgn0039848", "Q9W2C9", "FBgn0034660", "Q9V9X5", "FBgn0039848", "Q9W2C9", "FBgn0034660", "Q9V9X5", "FBgn0039848", "Q9VC47", "FBgn0004885", "P25723", "FBgn0003719" ] }, "reaction_10465381": { "compartment": "compartment_984", "id": "reaction_10465381", "reactome": "R-DME-2213201", "name": "Formation of collagen fibres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459394" ], "products": [ "species_10465379" ], "modifiers": [], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10459396": { "compartment": "compartment_984", "id": "reaction_10459396", "reactome": "R-DME-1474266", "name": "Formation of collagen fibrils", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459392" ], "products": [ "species_10459394" ], "modifiers": [], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10433228": { "compartment": "compartment_5460", "id": "reaction_10433228", "reactome": "R-DME-77345", "name": "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77308", "species_113596" ], "products": [ "species_77343", "species_31649" ], "modifiers": [ [ "species_10433219", "catalyst" ] ], "additional_components": [ "Q9VSA3", "FBgn0035811" ] }, "reaction_10433226": { "compartment": "compartment_5460", "id": "reaction_10433226", "reactome": "R-DME-77344", "name": "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113521" ], "products": [ "species_77341" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10494966": { "compartment": "compartment_5460", "id": "reaction_10494966", "reactome": "R-DME-8952873", "name": "MECR dimer reduces tdec2-CoA to DEC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77343", "species_113529", "species_113600" ], "products": [ "species_77308", "species_113563" ], "modifiers": [ [ "species_10494963", "catalyst" ] ], "additional_components": [ "Q9V6U9", "FBgn0033883" ] }, "reaction_10433224": { "compartment": "compartment_5460", "id": "reaction_10433224", "reactome": "R-DME-77340", "name": "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77339" ], "products": [ "species_77337", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_390061": { "compartment": "compartment_70101", "id": "reaction_390061", "reactome": "R-DME-390061", "name": "YKI binds to phosphorylated WTS", "reversible": "false", "notes": "The transcriptional factor Yorkie (YKI) via it's two WW domains binds to activated Warts (WTS) kinase. However, it appears that this particular binding has no detectable influence on YKI phosphorylation.", "reactants": [ "species_390114", "species_390068" ], "products": [ "species_390067" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q45VV3", "yki", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390044": { "compartment": "compartment_70101", "id": "reaction_390044", "reactome": "R-DME-390044", "name": "YKI is phosphorylated by and then dissociates from phosphorylated WTS", "reversible": "false", "notes": "The transcription factor Yorkie (YKI) is phosphorylated at Ser111, Ser168 and Ser250 by the activated serine/threonine kinase Warts (WTS).", "reactants": [ "species_113592", "species_390067" ], "products": [ "species_29370", "species_390064", "species_390068" ], "modifiers": [ [ "species_390067", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q45VV3", "yki", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV", "Q8T0S6", "HPO", "Q45VV3", "yki", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390078": { "compartment": "compartment_70101", "id": "reaction_390078", "reactome": "R-DME-390078", "name": "14-3-3 dimer binds to phosphorylated YKI", "reversible": "false", "notes": "The phosphorylated transcription factor Yorkie (YKI) associates with either one of the two 14-3-3 dimer isoforms (14-3-3epsilon or 14-3-3zeta). This effectively anchors YKI in the cytosol and prevents it entering the nucleus to activate its target genes.", "reactants": [ "species_390066", "species_390064" ], "products": [ "species_390163" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "P29310", "14-3-3zeta", "Q45VV3", "yki", "P92177", "14-3-3epsilon", "P29310", "14-3-3zeta" ] }, "reaction_10450831": { "compartment": "compartment_70101", "id": "reaction_10450831", "reactome": "R-DME-450092", "name": "GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450827" ], "products": [ "species_113592", "species_10450825" ], "modifiers": [], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "species_113592", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563" ] }, "reaction_10495569": { "compartment": "compartment_70101", "id": "reaction_10495569", "reactome": "R-DME-8981570", "name": "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10495566", "catalyst" ] ], "additional_components": [ "Q8IRI6", "FBgn0264574" ] }, "reaction_10450829": { "compartment": "compartment_70101", "id": "reaction_10450829", "reactome": "R-DME-450088", "name": "GLUT1 tetramer binds 4xATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10450825" ], "products": [ "species_10450827" ], "modifiers": [], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "species_113592" ] }, "reaction_10495571": { "compartment": "compartment_70101", "id": "reaction_10495571", "reactome": "R-DME-8981574", "name": "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10439537", "catalyst" ] ], "additional_components": [ "Q8IRI6", "FBgn0264574" ] }, "reaction_10448859": { "compartment": "compartment_876", "id": "reaction_10448859", "reactome": "R-DME-429094", "name": "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10448856", "catalyst" ] ], "additional_components": [ "A8JQU1", "FBgn0037386", "Q9VQP0", "FBgn0053282", "A0A1Z1CGZ4", "FBgn0037485", "Q7K2U8", "FBgn0028560", "Q9VQN6", "FBgn0031517", "Q7JVN6", "FBgn0037387", "Q9VI79", "FBgn0037486", "Q9W3S8", "FBgn0029932", "P53403", "FBgn0015230", "Q8MLQ7", "FBgn0034909", "Q9VU17", "FBgn0036316", "Q8MKK4", "FBgn0033644", "Q9VQP2", "FBgn0031523", "A1ZA52", "FBgn0034045", "Q8IPZ9", "FBgn0053282", "Q9VQP1", "FBgn0031522", "A1Z8N1", "FBgn0050035", "Q7K3P6", "FBgn0034247" ] }, "reaction_10495557": { "compartment": "compartment_70101", "id": "reaction_10495557", "reactome": "R-DME-8981553", "name": "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10495554", "catalyst" ] ], "additional_components": [ "Q0IGX4", "FBgn0033047", "Q7KJP2", "FBgn0028561", "Q7KK97", "FBgn0028563", "Q9U622", "FBgn0028562" ] }, "reaction_10471641": { "compartment": "compartment_70101", "id": "reaction_10471641", "reactome": "R-DME-5339524", "name": "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10450825", "catalyst" ], [ "species_10471639", "catalyst" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "FBgn0014135" ] }, "reaction_10448729": { "compartment": "compartment_876", "id": "reaction_10448729", "reactome": "R-DME-428779", "name": "GLUT7 and GLUT11 transport glucose and fructose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428819" ], "products": [ "species_428802" ], "modifiers": [ [ "species_10448724", "catalyst" ] ], "additional_components": [ "species_964746", "species_29532", "species_964746", "species_29532", "FBgn0264574" ] }, "reaction_10448760": { "compartment": "compartment_876", "id": "reaction_10448760", "reactome": "R-DME-429036", "name": "SLC2A9 transports Fru, Glc, urate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429078" ], "products": [ "species_429148" ], "modifiers": [ [ "species_10448757", "catalyst" ] ], "additional_components": [ "species_964746", "species_30034", "species_29532", "species_964746", "species_30034", "species_29532", "FBgn0264574" ] }, "reaction_10495562": { "compartment": "compartment_70101", "id": "reaction_10495562", "reactome": "R-DME-8981564", "name": "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10495559", "catalyst" ] ], "additional_components": [ "Q7KK97", "FBgn0028563" ] }, "reaction_10450834": { "compartment": "compartment_70101", "id": "reaction_10450834", "reactome": "R-DME-450095", "name": "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_70115" ], "modifiers": [ [ "species_10439537", "catalyst" ] ], "additional_components": [ "Q8IRI6", "FBgn0264574" ] }, "reaction_10448879": { "compartment": "compartment_876", "id": "reaction_10448879", "reactome": "R-DME-429594", "name": "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_264638", "species_74113" ], "products": [ "species_264618", "species_83910", "species_352022" ], "modifiers": [ [ "species_10448876", "catalyst" ] ], "additional_components": [ "FBgn0038641" ] }, "reaction_10449996": { "compartment": "compartment_876", "id": "reaction_10449996", "reactome": "R-DME-444120", "name": "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_266029", "species_74113" ], "products": [ "species_83910", "species_352022", "species_29424" ], "modifiers": [ [ "species_10449993", "catalyst" ] ], "additional_components": [ "Q7K330", "FBgn0033443", "A1ZBC7", "FBgn0034381", "Q9VSV2", "FBgn0035969", "A1Z8V9", "FBgn0033708", "Q9VLY6", "FBgn0267326", "Q9VLY5", "FBgn0031935", "Q9VLY4", "FBgn0031936", "Q9VLY3", "FBgn0031937", "Q9VJR4", "FBgn0028886", "Q7KTJ8", "FBgn0053296", "Q9W4C5", "FBgn0029762", "Q9W1J0", "FBgn0034911" ] }, "reaction_10449963": { "compartment": "compartment_876", "id": "reaction_10449963", "reactome": "R-DME-444100", "name": "PROT mediates L-proline uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_352033", "species_74113" ], "products": [ "species_83910", "species_113538", "species_352022" ], "modifiers": [ [ "species_10449960", "catalyst" ] ], "additional_components": [ "Q9VLY5", "FBgn0031935", "Q9VLY4", "FBgn0031936", "Q9VLY3", "FBgn0031937", "Q9VJR4", "FBgn0028886", "Q7KTJ8", "FBgn0053296", "Q9W4C5", "FBgn0029762", "Q7K330", "FBgn0033443", "Q9W1J0", "FBgn0034911", "A1ZBC7", "FBgn0034381", "Q9VSV2", "FBgn0035969", "A1Z8V9", "FBgn0033708", "Q9VLY6", "FBgn0267326" ] }, "reaction_10444219": { "compartment": "compartment_876", "id": "reaction_10444219", "reactome": "R-DME-352059", "name": "SLC6A15-mediated amino acid uptake", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352051", "species_74113" ], "products": [ "species_83910", "species_352048" ], "modifiers": [ [ "species_10444216", "catalyst" ] ], "additional_components": [ "species_29432", "species_29472", "CHEBI:58045", "species_379717", "species_351990", "species_111707", "species_200736", "species_29642", "species_351964", "species_379705", "species_6784215", "species_29702", "species_29472", "species_379717", "species_351990", "species_200736", "species_351964", "species_379705", "species_6784215", "CHEBI:58045", "species_29702", "species_29432", "species_29642", "species_111707", "Q8IQQ7", "FBgn0027660", "B7Z122", "FBgn0029663" ] }, "reaction_10450010": { "compartment": "compartment_876", "id": "reaction_10450010", "reactome": "R-DME-444160", "name": "VMAT1/2 can mediate the transport of biogenic amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444154" ], "products": [ "species_444152" ], "modifiers": [ [ "species_10450007", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "species_114523", "species_390899", "species_351597", "species_351597", "CHEBI:28918", "species_390899", "species_380873", "species_114523", "Q8IH57", "FBgn0260964", "Q9VCJ5", "FBgn0043005" ] }, "reaction_10444839": { "compartment": "compartment_876", "id": "reaction_10444839", "reactome": "R-DME-374896", "name": "Uptake of Noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10449926": { "compartment": "compartment_876", "id": "reaction_10449926", "reactome": "R-DME-443997", "name": "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935", "species_74113" ], "products": [ "species_209789", "species_83910" ], "modifiers": [ [ "species_10449923", "catalyst" ] ], "additional_components": [ "FBgn0034136" ] }, "reaction_10444198": { "compartment": "compartment_876", "id": "reaction_10444198", "reactome": "R-DME-351963", "name": "SLC6A18 transports Gly from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266029" ], "products": [ "species_29424" ], "modifiers": [ [ "species_10444195", "catalyst" ] ], "additional_components": [ "FBgn0029663" ] }, "reaction_10445109": { "compartment": "compartment_876", "id": "reaction_10445109", "reactome": "R-DME-375487", "name": "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_375468", "species_74113" ], "products": [ "species_83910", "species_375459", "species_352022" ], "modifiers": [ [ "species_10445106", "catalyst" ] ], "additional_components": [ "species_29432", "species_29500", "CHEBI:58045", "species_29612", "species_200736", "species_29424", "species_29468", "species_73590", "species_29444", "species_111707", "species_351964", "species_379705", "species_29702", "species_200736", "species_29702", "species_29612", "species_29444", "species_29424", "species_351964", "species_379705", "CHEBI:58045", "species_73590", "species_29432", "species_111707", "species_29468", "species_29500", "A1ZBC7", "FBgn0034381", "Q9VJR4", "FBgn0028886", "Q9VLY5", "FBgn0031935", "Q9W1J0", "FBgn0034911", "A1Z8V9", "FBgn0033708", "Q7KTJ8", "FBgn0053296", "Q9VLY4", "FBgn0031936", "Q9VSV2", "FBgn0035969", "Q7K330", "FBgn0033443", "Q9VLY3", "FBgn0031937", "Q9VLY6", "FBgn0267326", "Q9W4C5", "FBgn0029762" ] }, "reaction_10445044": { "compartment": "compartment_876", "id": "reaction_10445044", "reactome": "R-DME-375473", "name": "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375458", "species_74113" ], "products": [ "species_375481", "species_83910" ], "modifiers": [ [ "species_10445041", "catalyst" ] ], "additional_components": [ "species_29432", "species_29500", "species_29472", "CHEBI:58045", "species_111707", "species_200736", "species_29424", "species_351964", "species_379705", "species_29506", "species_29502", "species_29702", "species_29424", "species_29472", "species_29506", "species_200736", "species_351964", "species_379705", "CHEBI:58045", "species_29702", "species_29432", "species_111707", "species_29500", "species_29502", "Q8IQQ7", "FBgn0027660", "B7Z122", "FBgn0029663" ] }, "reaction_10444210": { "compartment": "compartment_876", "id": "reaction_10444210", "reactome": "R-DME-352052", "name": "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033", "species_74113" ], "products": [ "species_83910", "species_113538" ], "modifiers": [ [ "species_10444207", "catalyst" ] ], "additional_components": [ "Q8IQQ7", "FBgn0027660", "B7Z122", "FBgn0029663" ] }, "reaction_10495345": { "compartment": "compartment_70101", "id": "reaction_10495345", "reactome": "R-DME-8959798", "name": "SLC30A10 transports Mn2+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29418" ], "products": [ "species_266099" ], "modifiers": [ [ "species_10495342", "catalyst" ] ], "additional_components": [ "M9PEG6", "FBgn0035432", "Q9VPE3", "FBgn0037000" ] }, "reaction_10449676": { "compartment": "compartment_876", "id": "reaction_10449676", "reactome": "R-DME-435349", "name": "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_435347" ], "products": [ "species_70106", "species_71067" ], "modifiers": [ [ "species_10449673", "catalyst" ] ], "additional_components": [ "FBgn0011672" ] }, "reaction_10449684": { "compartment": "compartment_876", "id": "reaction_10449684", "reactome": "R-DME-435366", "name": "ZnT1 mediates the efflux of zinc from the cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_158417" ], "modifiers": [ [ "species_10449681", "catalyst" ] ], "additional_components": [ "FBgn0037000" ] }, "reaction_10449699": { "compartment": "compartment_20699", "id": "reaction_10449699", "reactome": "R-DME-437136", "name": "SLC30A8 transports Zn2+ from cytosol to secretory granule", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29426" ], "products": [ "species_216785" ], "modifiers": [ [ "species_10449696", "catalyst" ] ], "additional_components": [ "Q9VKA3", "FBgn0051860", "Q9V471", "FBgn0028516" ] }, "reaction_10449823": { "compartment": "compartment_876", "id": "reaction_10449823", "reactome": "R-DME-442387", "name": "ZIP8 mediates zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449820", "catalyst" ] ], "additional_components": [ "Q9VSL7", "FBgn0024236", "A4IJ72", "FBgn0036461" ] }, "reaction_10449831": { "compartment": "compartment_12045", "id": "reaction_10449831", "reactome": "R-DME-442393", "name": "ZIP7 mediates zinc efflux from the endoplasmic reticulum", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_442320" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449828", "catalyst" ] ], "additional_components": [ "FBgn0002022" ] }, "reaction_10449862": { "compartment": "compartment_876", "id": "reaction_10449862", "reactome": "R-DME-442422", "name": "SLC39A1-4 transports Zn2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449859", "catalyst" ] ], "additional_components": [ "Q9VFA2", "FBgn0038312", "Q9VEX1", "FBgn0038412", "Q7JZR2", "FBgn0033096", "A1Z6P0", "FBgn0033097", "Q9VSL7", "FBgn0024236" ] }, "reaction_10449812": { "compartment": "compartment_876", "id": "reaction_10449812", "reactome": "R-DME-442317", "name": "ZIP6 and ZIP14 mediate zinc influx into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158417" ], "products": [ "species_29426" ], "modifiers": [ [ "species_10449809", "catalyst" ] ], "additional_components": [ "Q9VSL7", "FBgn0024236", "A4IJ72", "FBgn0036461" ] }, "reaction_10449712": { "compartment": "compartment_876", "id": "reaction_10449712", "reactome": "R-DME-437300", "name": "SLC31A1 transports Cu2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_437295" ], "products": [ "species_209799" ], "modifiers": [ [ "species_10449709", "catalyst" ] ], "additional_components": [ "FBgn0062413" ] }, "reaction_10449872": { "compartment": "compartment_876", "id": "reaction_10449872", "reactome": "R-DME-442661", "name": "SLC41A1,2 transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10449867", "catalyst" ] ], "additional_components": [ "FBgn0053181" ] }, "reaction_10450071": { "compartment": "compartment_984", "id": "reaction_10450071", "reactome": "R-DME-444433", "name": "Cho transports from the extracellular space to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264638" ], "products": [ "species_264618" ], "modifiers": [ [ "species_10450068", "catalyst" ] ], "additional_components": [ "Q9VAP3", "FBgn0039637", "Q9VZE7", "FBgn0035523" ] }, "reaction_10449579": { "compartment": "compartment_876", "id": "reaction_10449579", "reactome": "R-DME-433104", "name": "NACT co-transports trivalent citrate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433138", "species_74113" ], "products": [ "species_76190", "species_83910" ], "modifiers": [ [ "species_10449576", "catalyst" ] ], "additional_components": [ "FBgn0036816" ] }, "reaction_10449561": { "compartment": "compartment_876", "id": "reaction_10449561", "reactome": "R-DME-433099", "name": "NaS2 co-transports sulphate and two sodium ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10449558", "catalyst" ] ], "additional_components": [ "Q9VDQ0", "FBgn0260466", "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816" ] }, "reaction_10449592": { "compartment": "compartment_876", "id": "reaction_10449592", "reactome": "R-DME-433114", "name": "NaS1 co-transports sulphate and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648", "species_74113" ], "products": [ "species_83910", "species_174375" ], "modifiers": [ [ "species_10449589", "catalyst" ] ], "additional_components": [ "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816", "Q9VDQ0", "FBgn0260466" ] }, "reaction_10449574": { "compartment": "compartment_876", "id": "reaction_10449574", "reactome": "R-DME-433101", "name": "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433123", "species_74113" ], "products": [ "species_29434", "species_83910" ], "modifiers": [ [ "species_10449571", "catalyst" ] ], "additional_components": [ "Q9VDQ0", "FBgn0260466", "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816" ] }, "reaction_10449605": { "compartment": "compartment_876", "id": "reaction_10449605", "reactome": "R-DME-433131", "name": "NaDC1 co-transports dicarboxylic acids and a sodium ion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433111", "species_74113" ], "products": [ "species_83910", "species_433124" ], "modifiers": [ [ "species_10449602", "catalyst" ] ], "additional_components": [ "species_29654", "species_29434", "species_29434", "species_29654", "Q9VDQ0", "FBgn0260466", "Q7KTF1", "FBgn0032314", "E1JIQ7", "FBgn0064119", "Q9VVT2", "FBgn0036816" ] }, "reaction_10453615": { "compartment": "compartment_876", "id": "reaction_10453615", "reactome": "R-DME-561054", "name": "OCT2 mediates tubular secretion of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549266" ], "products": [ "species_549237" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:6801", "CHEBI:16797", "CHEBI:16737", "species_264638", "CHEBI:65133", "CHEBI:641", "species_114523", "species_351164", "species_390899", "CHEBI:31941", "species_351597", "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_351597", "CHEBI:65133", "species_351164", "species_390899", "species_264638", "CHEBI:16797", "species_114523", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10453453": { "compartment": "compartment_876", "id": "reaction_10453453", "reactome": "R-DME-549297", "name": "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10453450", "catalyst" ] ], "additional_components": [ "Q9VD40", "FBgn0038938", "Q9VCA0", "FBgn0039178", "Q961R9", "FBgn0038407", "A2RVG5", "FBgn0063649", "Q9VNX2", "FBgn0037140", "Q9VNW8", "FBgn0037144", "Q9VEY1", "FBgn0038404" ] }, "reaction_10453430": { "compartment": "compartment_876", "id": "reaction_10453430", "reactome": "R-DME-549279", "name": "OCT2 mediates tubular uptake of organic cations in the kidney", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549237" ], "products": [ "species_549266" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "CHEBI:31941", "CHEBI:16737", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_351597", "CHEBI:65133", "species_351164", "species_390899", "species_264638", "CHEBI:16797", "species_114523", "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:6801", "CHEBI:16797", "CHEBI:16737", "species_264638", "CHEBI:65133", "CHEBI:641", "species_114523", "species_351164", "species_390899", "CHEBI:31941", "species_351597", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10453654": { "compartment": "compartment_876", "id": "reaction_10453654", "reactome": "R-DME-561072", "name": "OCT3 mediates renal uptake of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549255" ], "products": [ "species_549326" ], "modifiers": [ [ "species_10453455", "catalyst" ] ], "additional_components": [ "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "FBgn0034479" ] }, "reaction_10453365": { "compartment": "compartment_876", "id": "reaction_10453365", "reactome": "R-DME-549129", "name": "OCT1 transports organic cations into hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549264" ], "products": [ "species_549250" ], "modifiers": [ [ "species_10453362", "catalyst" ] ], "additional_components": [ "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_141324", "CHEBI:15854", "species_351597", "CHEBI:65133", "species_390899", "species_141342", "species_264638", "CHEBI:16797", "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "CHEBI:16797", "species_264638", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_141342", "species_351597", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "D2NUL5", "FBgn0264907", "Q9VDS2", "FBgn0038750" ] }, "reaction_10453460": { "compartment": "compartment_876", "id": "reaction_10453460", "reactome": "R-DME-549322", "name": "OCT1 transports organic cations out of hepatic cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549250" ], "products": [ "species_549264" ], "modifiers": [ [ "species_10453362", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "CHEBI:46020", "CHEBI:42820", "CHEBI:6801", "CHEBI:16797", "species_264638", "CHEBI:65133", "CHEBI:15854", "species_141324", "CHEBI:641", "species_390899", "species_141342", "species_351597", "CHEBI:42820", "CHEBI:641", "CHEBI:46020", "species_380873", "CHEBI:6801", "CHEBI:28918", "species_141324", "CHEBI:15854", "species_351597", "CHEBI:65133", "species_390899", "species_141342", "species_264638", "CHEBI:16797", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "D2NUL5", "FBgn0264907", "Q9VDS2", "FBgn0038750" ] }, "reaction_10453458": { "compartment": "compartment_876", "id": "reaction_10453458", "reactome": "R-DME-549304", "name": "OCT3 mediates renal clearance of organic cations", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549326" ], "products": [ "species_549255" ], "modifiers": [ [ "species_10453455", "catalyst" ] ], "additional_components": [ "CHEBI:8428", "CHEBI:46020", "CHEBI:42820", "CHEBI:47499", "CHEBI:47781", "CHEBI:641", "CHEBI:46631", "CHEBI:47781", "CHEBI:8428", "CHEBI:42820", "CHEBI:47499", "CHEBI:641", "CHEBI:46020", "CHEBI:46631", "FBgn0034479" ] }, "reaction_10453426": { "compartment": "compartment_876", "id": "reaction_10453426", "reactome": "R-DME-549241", "name": "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549261", "species_74113" ], "products": [ "species_83910", "species_549260" ], "modifiers": [ [ "species_10453401", "catalyst" ], [ "species_10453424", "inhibitor" ] ], "additional_components": [ "Q9VCA0", "FBgn0039178", "Q961R9", "FBgn0038407", "A2RVG5", "FBgn0063649", "Q9VNX2", "FBgn0037140", "Q9VNW8", "FBgn0037144", "Q9VEY1", "FBgn0038404", "Q9VD40", "FBgn0038938", "M9PI08", "FBgn0083981", "Q9W349", "FBgn0002576", "Q9VRA9", "FBgn0259162", "P22814", "FBgn0003300" ] }, "reaction_10453613": { "compartment": "compartment_876", "id": "reaction_10453613", "reactome": "R-DME-561041", "name": "OAT1-3 transport organic anions with antiport of dicarboxylic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561049" ], "products": [ "species_561078", "species_561075" ], "modifiers": [ [ "species_10453610", "catalyst" ] ], "additional_components": [ "CHEBI:104011", "species_561052", "species_561052", "CHEBI:104011", "Q9VDV8", "FBgn0038717", "Q9VRQ8", "FBgn0035645", "Q9VDV7", "FBgn0038718", "Q9VFG2", "FBgn0038260", "Q9VDV6", "FBgn0038719", "Q9VFG1", "FBgn0038261", "Q9VDV5", "FBgn0038720", "Q9VFG0", "FBgn0038262", "Q9VCA2", "FBgn0019952", "Q9VDW0", "FBgn0038715", "Q9VRT4", "FBgn0259164", "Q95R48", "FBgn0086365", "Q9VDV9", "FBgn0038716", "Q9VRR0", "FBgn0035647", "Q86NP5", "FBgn0053233" ] }, "reaction_10453689": { "compartment": "compartment_876", "id": "reaction_10453689", "reactome": "R-DME-561253", "name": "SLC22A12 exchanges extracellular urate for cytosolic LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_429056" ], "products": [ "species_373863", "species_30034" ], "modifiers": [ [ "species_10453686", "catalyst" ] ], "additional_components": [ "Q9VDV5", "FBgn0038720", "Q9VCA2", "FBgn0019952", "Q95R48", "FBgn0086365", "Q86NP5", "FBgn0053233", "Q9VRT4", "FBgn0259164", "Q9VRR0", "FBgn0035647", "Q9VRQ8", "FBgn0035645", "Q9VFG2", "FBgn0038260", "Q9VFG1", "FBgn0038261", "Q9VFG0", "FBgn0038262", "Q9VDW0", "FBgn0038715", "Q9VDV9", "FBgn0038716", "Q9VDV8", "FBgn0038717", "Q9VDV7", "FBgn0038718", "Q9VDV6", "FBgn0038719" ] }, "reaction_10453652": { "compartment": "compartment_876", "id": "reaction_10453652", "reactome": "R-DME-561059", "name": "OAT2 and OAT4 mediate transport of sulphate conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_561071" ], "products": [ "species_561062", "species_561075" ], "modifiers": [ [ "species_10453649", "catalyst" ] ], "additional_components": [ "species_176496", "species_176501", "species_176501", "species_176496", "Q9VDV9", "FBgn0038716", "Q9VDV8", "FBgn0038717", "Q9VDV7", "FBgn0038718", "Q9VDV6", "FBgn0038719", "Q9VDV5", "FBgn0038720", "Q9VCA2", "FBgn0019952", "Q95R48", "FBgn0086365", "Q86NP5", "FBgn0053233", "Q9VRT4", "FBgn0259164", "Q9VRR0", "FBgn0035647", "Q9VRQ8", "FBgn0035645", "Q9VFG2", "FBgn0038260", "Q9VFG1", "FBgn0038261", "Q9VFG0", "FBgn0038262", "Q9VDW0", "FBgn0038715" ] }, "reaction_10449536": { "compartment": "compartment_876", "id": "reaction_10449536", "reactome": "R-DME-433089", "name": "SOAT can transport taurolithocholate-3-sulphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_433120", "species_74113" ], "products": [ "species_83910", "species_176483" ], "modifiers": [ [ "species_10449533", "catalyst" ] ], "additional_components": [ "Q9VXV4", "FBgn0030638", "Q9VXF5", "FBgn0030756" ] }, "reaction_10450045": { "compartment": "compartment_876", "id": "reaction_10450045", "reactome": "R-DME-444416", "name": "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31633" ], "products": [ "species_140912" ], "modifiers": [ [ "species_10450042", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450557": { "compartment": "compartment_876", "id": "reaction_10450557", "reactome": "R-DME-446278", "name": "RhBG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10450047", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450555": { "compartment": "compartment_876", "id": "reaction_10450555", "reactome": "R-DME-446277", "name": "RhCG mediates ammonium efflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10450037", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450040": { "compartment": "compartment_876", "id": "reaction_10450040", "reactome": "R-DME-444393", "name": "RhCG mediates ammonium influx into kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_140912" ], "products": [ "species_351626", "species_31633" ], "modifiers": [ [ "species_10450037", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10450050": { "compartment": "compartment_876", "id": "reaction_10450050", "reactome": "R-DME-444419", "name": "RhBG mediates ammonium effflux out of kidney collecting duct cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_31633" ], "products": [ "species_70106", "species_140912" ], "modifiers": [ [ "species_10450047", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10436318": { "compartment": "compartment_70616", "id": "reaction_10436318", "reactome": "R-DME-163215", "name": "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_113593" ], "products": [ "species_113581", "species_113592" ], "modifiers": [ [ "species_10436315", "catalyst" ] ], "additional_components": [ "Q26365", "FBgn0003360", "O62526", "FBgn0025111" ] }, "reaction_10433387": { "compartment": "compartment_70101", "id": "reaction_10433387", "reactome": "R-DME-109536", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737" ], "products": [ "species_179743" ], "modifiers": [ [ "species_10433362", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "FBgn0031250" ] }, "reaction_10453898": { "compartment": "compartment_70101", "id": "reaction_10453898", "reactome": "R-DME-727749", "name": "SLC29A3 transports nucleosides from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727782" ], "products": [ "species_727746" ], "modifiers": [ [ "species_10453895", "catalyst" ] ], "additional_components": [ "species_83908", "species_83927", "CHEBI:16704", "CHEBI:16750", "CHEBI:17562", "CHEBI:17748", "species_83951", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_83951", "FBgn0031250" ] }, "reaction_10433401": { "compartment": "compartment_70101", "id": "reaction_10433401", "reactome": "R-DME-109539", "name": "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179740", "species_74113" ], "products": [ "species_179741", "species_83910" ], "modifiers": [ [ "species_10433398", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "species_83908", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "Q7K4A1", "FBgn0025709", "A1Z7N3", "FBgn0033371" ] }, "reaction_10433385": { "compartment": "compartment_70101", "id": "reaction_10433385", "reactome": "R-DME-109534", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179743" ], "products": [ "species_179737" ], "modifiers": [ [ "species_10433362", "catalyst" ] ], "additional_components": [ "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "FBgn0031250" ] }, "reaction_10433367": { "compartment": "compartment_70101", "id": "reaction_10433367", "reactome": "R-DME-109529", "name": "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179742" ], "products": [ "species_179747" ], "modifiers": [ [ "species_10433360", "catalyst" ] ], "additional_components": [ "species_83908", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_29692", "species_29554", "CHEBI:17562", "species_83951", "species_113599", "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "CHEBI:17748", "species_113599", "species_83908", "species_29692", "species_29554", "species_83951", "CHEBI:17562", "CHEBI:16040", "FBgn0031250" ] }, "reaction_10433382": { "compartment": "compartment_70101", "id": "reaction_10433382", "reactome": "R-DME-109530", "name": "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179738", "species_74113" ], "products": [ "species_179739", "species_83910" ], "modifiers": [ [ "species_10433379", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "CHEBI:17256", "CHEBI:17256", "species_83908", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "A1Z7N3", "FBgn0033371", "Q7K4A1", "FBgn0025709" ] }, "reaction_10453910": { "compartment": "compartment_70101", "id": "reaction_10453910", "reactome": "R-DME-727768", "name": "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727737" ], "products": [ "species_727774" ], "modifiers": [ [ "species_10453890", "catalyst" ] ], "additional_components": [ "species_380873", "CHEBI:28918", "species_83908", "species_114523", "species_351597", "species_351597", "species_83908", "species_114523", "species_380873", "CHEBI:28918", "FBgn0036319" ] }, "reaction_10433365": { "compartment": "compartment_70101", "id": "reaction_10433365", "reactome": "R-DME-109527", "name": "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179747" ], "products": [ "species_179742" ], "modifiers": [ [ "species_10433360", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "species_83956", "CHEBI:16704", "CHEBI:17748", "species_113599", "species_83908", "species_29692", "species_29554", "species_83951", "CHEBI:17562", "CHEBI:16040", "species_83908", "CHEBI:16040", "species_83956", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_29692", "species_29554", "CHEBI:17562", "species_83951", "species_113599", "FBgn0031250" ] }, "reaction_10453893": { "compartment": "compartment_70101", "id": "reaction_10453893", "reactome": "R-DME-727740", "name": "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727774" ], "products": [ "species_727737" ], "modifiers": [ [ "species_10453890", "catalyst" ] ], "additional_components": [ "species_351597", "species_83908", "species_114523", "species_380873", "CHEBI:28918", "species_380873", "CHEBI:28918", "species_83908", "species_114523", "species_351597", "FBgn0036319" ] }, "reaction_10433392": { "compartment": "compartment_70101", "id": "reaction_10433392", "reactome": "R-DME-109538", "name": "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179737", "species_74113" ], "products": [ "species_179743", "species_83910" ], "modifiers": [ [ "species_10433389", "catalyst" ] ], "additional_components": [ "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "species_83908", "CHEBI:17562", "species_83908", "species_83927", "CHEBI:16750", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "FBgn0025709" ] }, "reaction_10454262": { "compartment": "compartment_876", "id": "reaction_10454262", "reactome": "R-DME-879585", "name": "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879559" ], "products": [ "species_879544" ], "modifiers": [ [ "species_10454259", "catalyst" ] ], "additional_components": [ "CHEBI:16196", "CHEBI:16196", "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10453918": { "compartment": "compartment_20699", "id": "reaction_10453918", "reactome": "R-DME-727807", "name": "SLC35A1 exchanges CMP-Neu5Ac for CMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727810", "species_4085435" ], "products": [ "species_727815", "species_109395" ], "modifiers": [ [ "species_10453915", "catalyst" ] ], "additional_components": [ "FBgn0024994" ] }, "reaction_10453946": { "compartment": "compartment_20699", "id": "reaction_10453946", "reactome": "R-DME-742345", "name": "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742368" ], "products": [ "species_205683" ], "modifiers": [ [ "species_10453943", "catalyst" ] ], "additional_components": [ "FBgn0265351" ] }, "reaction_10453962": { "compartment": "compartment_20699", "id": "reaction_10453962", "reactome": "R-DME-744230", "name": "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_744239" ], "products": [ "species_113578", "species_744233" ], "modifiers": [ [ "species_10453959", "catalyst" ] ], "additional_components": [ "FBgn0042641" ] }, "reaction_10453957": { "compartment": "compartment_20699", "id": "reaction_10453957", "reactome": "R-DME-742373", "name": "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742353" ], "products": [ "species_742361" ], "modifiers": [ [ "species_10453951", "catalyst" ] ], "additional_components": [ "FBgn0029849" ] }, "reaction_10453923": { "compartment": "compartment_20699", "id": "reaction_10453923", "reactome": "R-DME-735702", "name": "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735698", "species_735692" ], "products": [ "species_109402", "species_735691" ], "modifiers": [ [ "species_10453920", "catalyst" ] ], "additional_components": [ "species_735700", "species_735682", "species_735682", "species_735700", "FBgn0024994" ] }, "reaction_10453938": { "compartment": "compartment_20699", "id": "reaction_10453938", "reactome": "R-DME-741449", "name": "SLC35B2,3 transport cytosolic PAPS to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471" ], "products": [ "species_741440" ], "modifiers": [ [ "species_10453935", "catalyst" ] ], "additional_components": [ "Q9VVD9", "FBgn0036695", "Q9VEI3", "FBgn0038524" ] }, "reaction_10453954": { "compartment": "compartment_20699", "id": "reaction_10453954", "reactome": "R-DME-742354", "name": "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756" ], "products": [ "species_914003" ], "modifiers": [ [ "species_10453951", "catalyst" ] ], "additional_components": [ "FBgn0029849" ] }, "reaction_10453906": { "compartment": "compartment_20699", "id": "reaction_10453906", "reactome": "R-DME-727759", "name": "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183" ], "products": [ "species_727753" ], "modifiers": [ [ "species_10453903", "catalyst" ] ], "additional_components": [ "FBgn0036662" ] }, "reaction_10454239": { "compartment": "compartment_876", "id": "reaction_10454239", "reactome": "R-DME-879575", "name": "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10454236", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "Q9VLB3", "FBgn0032123", "C8VV48", "FBgn0001296", "Q9W270", "FBgn0034715", "Q9VK82", "FBgn0032435", "Q9W269", "FBgn0034716", "Q8SY02", "FBgn0051634", "Q9VVH9", "FBgn0036732", "Q9W271", "FBgn0050277", "Q9VK84", "FBgn0032433" ] }, "reaction_10454189": { "compartment": "compartment_876", "id": "reaction_10454189", "reactome": "R-DME-879562", "name": "SLCO2B1 has a narrow substrate specificity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879553" ], "products": [ "species_879654" ], "modifiers": [ [ "species_10454186", "catalyst" ] ], "additional_components": [ "species_176496", "CHEBI:63836", "species_176501", "CHEBI:63836", "species_176501", "species_176496", "FBgn0032123" ] }, "reaction_10454267": { "compartment": "compartment_876", "id": "reaction_10454267", "reactome": "R-DME-879594", "name": "SLCO4C1 mediates the transport of digoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879521" ], "products": [ "species_879517" ], "modifiers": [ [ "species_10454264", "catalyst" ] ], "additional_components": [ "FBgn0051634" ] }, "reaction_10497799": { "compartment": "compartment_876", "id": "reaction_10497799", "reactome": "R-DME-9631987", "name": "SLCO1B1 transports T3,T4 from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879603" ], "products": [ "species_879628" ], "modifiers": [ [ "species_10454191", "catalyst" ] ], "additional_components": [ "species_352326", "species_176667", "species_352326", "species_176667", "FBgn0032123" ] }, "reaction_10454184": { "compartment": "compartment_876", "id": "reaction_10454184", "reactome": "R-DME-879528", "name": "SLCO2A1 transports PGT substrates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_879566" ], "products": [ "species_879614" ], "modifiers": [ [ "species_10454181", "catalyst" ] ], "additional_components": [ "species_879535", "CHEBI:15544", "species_416911", "species_265287", "species_416911", "CHEBI:15544", "species_879535", "species_265287", "FBgn0032123" ] }, "reaction_10448447": { "compartment": "compartment_876", "id": "reaction_10448447", "reactome": "R-DME-428015", "name": "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428027", "species_29804", "species_74113" ], "products": [ "species_74126", "species_427997", "species_70106", "species_83910" ], "modifiers": [ [ "species_10442846", "catalyst" ] ], "additional_components": [ "species_113553", "species_6810061", "species_210382", "species_113553", "species_6810061", "species_210382", "FBgn0026438" ] }, "reaction_10448637": { "compartment": "compartment_201753", "id": "reaction_10448637", "reactome": "R-DME-428625", "name": "Vesicular inhibitory amino acid transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428592", "species_428548" ], "products": [ "species_428632", "species_70106" ], "modifiers": [ [ "species_10448634", "catalyst" ] ], "additional_components": [ "species_29424", "species_352011", "species_352011", "species_29424", "FBgn0033911" ] }, "reaction_10474318": { "compartment": "compartment_70101", "id": "reaction_10474318", "reactome": "R-DME-5627802", "name": "SLC26A4 transports I- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10474315", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10448410": { "compartment": "compartment_876", "id": "reaction_10448410", "reactome": "R-DME-427666", "name": "SLC26A3,6 exchange Cl- for HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10448405", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10448393": { "compartment": "compartment_876", "id": "reaction_10448393", "reactome": "R-DME-427570", "name": "Group 3 - Selective Cl- transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10448390", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10448388": { "compartment": "compartment_876", "id": "reaction_10448388", "reactome": "R-DME-427555", "name": "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_427648" ], "products": [ "species_70106", "species_174375" ], "modifiers": [ [ "species_10448383", "catalyst" ] ], "additional_components": [ "FBgn0036770" ] }, "reaction_10491197": { "compartment": "compartment_70101", "id": "reaction_10491197", "reactome": "R-DME-8875871", "name": "SLC26A11 transports SO4(2-) from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427648" ], "products": [ "species_174375" ], "modifiers": [ [ "species_10491194", "catalyst" ] ], "additional_components": [ "FBgn0036240" ] }, "reaction_10491278": { "compartment": "compartment_70101", "id": "reaction_10491278", "reactome": "R-DME-8876312", "name": "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876310", "species_74113" ], "products": [ "species_83910", "species_8876304" ], "modifiers": [ [ "species_10491275", "catalyst" ] ], "additional_components": [ "species_113557", "species_373863", "species_8869604", "species_113557", "species_373863", "species_197230", "P83740", "FBgn0052669", "Q8SWV5", "FBgn0034494" ] }, "reaction_10489060": { "compartment": "compartment_70101", "id": "reaction_10489060", "reactome": "R-DME-8855062", "name": "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162252", "species_71284" ], "products": [ "species_2162265", "species_71285" ], "modifiers": [ [ "species_10489057", "catalyst" ] ], "additional_components": [ "FBgn0039357" ] }, "reaction_10448403": { "compartment": "compartment_876", "id": "reaction_10448403", "reactome": "R-DME-427605", "name": "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109277", "species_74113" ], "products": [ "species_29372", "species_83910" ], "modifiers": [ [ "species_10448398", "catalyst" ] ], "additional_components": [ "FBgn0260795" ] }, "reaction_10448445": { "compartment": "compartment_876", "id": "reaction_10448445", "reactome": "R-DME-427998", "name": "Proton-coupled di- and tri-peptide cotransport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_428037" ], "products": [ "species_428026", "species_70106" ], "modifiers": [ [ "species_10448442", "catalyst" ] ], "additional_components": [ "CHEBI:90799", "CHEBI:47923", "CHEBI:47923", "CHEBI:90799", "FBgn0028491" ] }, "reaction_10471671": { "compartment": "compartment_70101", "id": "reaction_10471671", "reactome": "R-DME-5340130", "name": "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_5673778" ], "products": [ "species_70106", "species_379444" ], "modifiers": [ [ "species_10471668", "catalyst" ] ], "additional_components": [ "FBgn0039045" ] }, "reaction_10448940": { "compartment": "compartment_876", "id": "reaction_10448940", "reactome": "R-DME-429767", "name": "Passive I- efflux mediated by SMCT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209785" ], "products": [ "species_209818" ], "modifiers": [ [ "species_10448934", "catalyst" ] ], "additional_components": [ "FBgn0034494" ] }, "reaction_10448937": { "compartment": "compartment_876", "id": "reaction_10448937", "reactome": "R-DME-429749", "name": "SLC5A8 transports monocarboxylates from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429739", "species_74113" ], "products": [ "species_83910", "species_429748" ], "modifiers": [ [ "species_10448934", "catalyst" ] ], "additional_components": [ "species_113557", "species_373863", "species_8869604", "CHEBI:30772", "species_29416", "CHEBI:30768", "CHEBI:30772", "species_113557", "species_29416", "species_373863", "CHEBI:30768", "species_197230", "FBgn0034494" ] }, "reaction_10448456": { "compartment": "compartment_201753", "id": "reaction_10448456", "reactome": "R-DME-428052", "name": "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_428548" ], "products": [ "species_70106", "species_428614" ], "modifiers": [ [ "species_10448449", "catalyst" ] ], "additional_components": [ "FBgn0031424" ] }, "reaction_10448871": { "compartment": "compartment_876", "id": "reaction_10448871", "reactome": "R-DME-429591", "name": "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10442820", "catalyst" ] ], "additional_components": [ "P83740", "FBgn0052669", "Q8SWV5", "FBgn0034494" ] }, "reaction_10448629": { "compartment": "compartment_17938", "id": "reaction_10448629", "reactome": "R-DME-428585", "name": "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428040", "species_428639" ], "products": [ "species_428633", "species_70106" ], "modifiers": [ [ "species_10448626", "catalyst" ] ], "additional_components": [ "FBgn0030452" ] }, "reaction_10491181": { "compartment": "compartment_70101", "id": "reaction_10491181", "reactome": "R-DME-8875623", "name": "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_113529", "species_113552" ], "modifiers": [ [ "species_10491178", "catalyst" ] ], "additional_components": [ "Q9VGF7", "FBgn0260743", "Q8INJ3", "FBgn0037970" ] }, "reaction_10460673": { "compartment": "compartment_70616", "id": "reaction_10460673", "reactome": "R-DME-1614546", "name": "Sulfate is exported to the cytosol in exchange for dicarboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_1614584" ], "products": [ "species_113544", "species_174375" ], "modifiers": [ [ "species_10444381", "catalyst" ] ], "additional_components": [ "FBgn0027610" ] }, "reaction_10444384": { "compartment": "compartment_70101", "id": "reaction_10444384", "reactome": "R-DME-372843", "name": "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_113544" ], "products": [ "species_113548", "species_198498" ], "modifiers": [ [ "species_10444381", "catalyst" ] ], "additional_components": [ "FBgn0027610" ] }, "reaction_10445035": { "compartment": "compartment_876", "id": "reaction_10445035", "reactome": "R-DME-375417", "name": "SLC36A1-mediated uptake of glycine, proline, and alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375400" ], "products": [ "species_70106", "species_375411" ], "modifiers": [ [ "species_10445032", "catalyst" ] ], "additional_components": [ "species_29432", "species_379717", "species_29424", "species_29424", "species_379717", "species_29432", "FBgn0032036" ] }, "reaction_10445030": { "compartment": "compartment_876", "id": "reaction_10445030", "reactome": "R-DME-375405", "name": "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_375409" ], "products": [ "species_70106", "species_375414" ], "modifiers": [ [ "species_10445027", "catalyst" ] ], "additional_components": [ "species_379717", "species_29424", "species_29424", "species_379717", "M9PEU1", "FBgn0263776", "Q7K2W3", "FBgn0033760", "Q9VT04", "FBgn0036007", "Q9VX84", "FBgn0030816", "Q4V5R4", "FBgn0033572", "Q9VLM3", "FBgn0032036", "Q9VTD7", "FBgn0036116", "M9PHT8", "FBgn0030817", "Q8IQF3", "FBgn0052081", "Q9VTD5", "FBgn0052079", "Q9W056", "FBgn0035300" ] }, "reaction_10448095": { "compartment": "compartment_876", "id": "reaction_10448095", "reactome": "R-DME-425482", "name": "SLC4A1,2,3 exchanges HCO3- for Cl-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_111627" ], "products": [ "species_425425", "species_352022" ], "modifiers": [ [ "species_10448088", "catalyst" ] ], "additional_components": [ "FBgn0036043" ] }, "reaction_10448107": { "compartment": "compartment_876", "id": "reaction_10448107", "reactome": "R-DME-425483", "name": "SLC4A5,7,9 cotransport Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10448100", "catalyst" ] ], "additional_components": [ "FBgn0259111" ] }, "reaction_10491757": { "compartment": "compartment_876", "id": "reaction_10491757", "reactome": "R-DME-8878664", "name": "SLC4A4 cotransports Na+ with 3HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_83910" ], "products": [ "species_425425", "species_74113" ], "modifiers": [ [ "species_10491752", "catalyst" ], [ "species_10491755", "catalyst" ] ], "additional_components": [ "FBgn0259111", "FBgn0035371" ] }, "reaction_10448114": { "compartment": "compartment_876", "id": "reaction_10448114", "reactome": "R-DME-425577", "name": "Na+-driven Cl-/HCO3- exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_425425", "species_352022", "species_74113" ], "products": [ "species_351626", "species_188972", "species_111627", "species_83910" ], "modifiers": [ [ "species_10448109", "catalyst" ] ], "additional_components": [ "FBgn0259111" ] }, "reaction_10474206": { "compartment": "compartment_263163", "id": "reaction_10474206", "reactome": "R-DME-5626316", "name": "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5626313", "species_83910", "species_167012" ], "products": [ "species_29804", "species_74016", "species_425958" ], "modifiers": [ [ "species_10474203", "catalyst" ] ], "additional_components": [ "Q9VN12", "FBgn0037238", "Q7PLW4", "FBgn0039941", "Q5LJX8", "FBgn0265767", "A8Y5A2", "FBgn0040031" ] }, "reaction_10448158": { "compartment": "compartment_876", "id": "reaction_10448158", "reactome": "R-DME-425822", "name": "K+-independent Li+/Ca2+ exchanger transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425815", "species_74016" ], "products": [ "species_425810", "species_74112" ], "modifiers": [ [ "species_10448155", "catalyst" ] ], "additional_components": [ "FBgn0033324" ] }, "reaction_10448150": { "compartment": "compartment_876", "id": "reaction_10448150", "reactome": "R-DME-425678", "name": "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804", "species_74016", "species_74113" ], "products": [ "species_74126", "species_83910", "species_74112" ], "modifiers": [ [ "species_10448147", "catalyst" ] ], "additional_components": [ "Q9VN12", "FBgn0037238", "Q9U6A0", "FBgn0028704", "Q7PLW4", "FBgn0039941", "Q5LJX8", "FBgn0265767", "A8Y5A2", "FBgn0040031" ] }, "reaction_10444254": { "compartment": "compartment_876", "id": "reaction_10444254", "reactome": "R-DME-352379", "name": "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352036", "species_29472", "species_74113" ], "products": [ "species_29432", "species_83910", "species_212615", "species_74113" ], "modifiers": [ [ "species_10444251", "catalyst" ] ], "additional_components": [ "FBgn0026438" ] }, "reaction_10445150": { "compartment": "compartment_876", "id": "reaction_10445150", "reactome": "R-DME-375790", "name": "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445126", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q9VNP7", "FBgn0037203", "Q2PDY3", "FBgn0036493", "Q9VVM0", "FBgn0036764" ] }, "reaction_10445148": { "compartment": "compartment_876", "id": "reaction_10445148", "reactome": "R-DME-375776", "name": "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445145", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q9VVM0", "FBgn0036764", "Q9VNP7", "FBgn0037203", "Q2PDY3", "FBgn0036493" ] }, "reaction_10495333": { "compartment": "compartment_70101", "id": "reaction_10495333", "reactome": "R-DME-8959781", "name": "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8959777" ], "products": [ "species_8959775" ], "modifiers": [ [ "species_10495330", "catalyst" ] ], "additional_components": [ "CHEBI:28229", "species_113585", "species_29468", "species_29612", "species_29444", "CHEBI:27747", "species_113585", "species_29444", "species_29468", "species_29612", "CHEBI:28229", "CHEBI:27747", "FBgn0032219" ] }, "reaction_10444249": { "compartment": "compartment_876", "id": "reaction_10444249", "reactome": "R-DME-352371", "name": "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83910", "species_352355", "species_352000", "species_74113" ], "products": [ "species_83910", "species_351990", "species_352359", "species_74113" ], "modifiers": [ [ "species_10444240", "catalyst" ] ], "additional_components": [ "species_200736", "species_351990", "species_29432", "species_111707", "species_29432", "species_351990", "species_111707", "species_200736", "FBgn0026438" ] }, "reaction_10445650": { "compartment": "compartment_876", "id": "reaction_10445650", "reactome": "R-DME-379432", "name": "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29588", "species_379430" ], "products": [ "species_351964", "species_379440" ], "modifiers": [ [ "species_10445647", "catalyst" ] ], "additional_components": [ "species_379444", "species_29444", "species_29468", "species_379444", "species_29468", "species_29444", "Q8IR48", "FBgn0030574", "A1Z7E8", "FBgn0033294", "A1Z7F3", "FBgn0033297", "P07192", "FBgn0002571", "A0A4P1SA55", "FBgn0032382", "A1Z7F2", "FBgn0033296", "P07191", "FBgn0002569", "Q9VKE6", "FBgn0032381", "A1Z7F1", "FBgn0050360", "P07190", "FBgn0002570", "Q5U124", "FBgn0050359" ] }, "reaction_10445137": { "compartment": "compartment_876", "id": "reaction_10445137", "reactome": "R-DME-375770", "name": "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445134", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "FBgn0032911" ] }, "reaction_10490484": { "compartment": "compartment_876", "id": "reaction_10490484", "reactome": "R-DME-8870354", "name": "SLC36A4 transports extracellular L-Pro to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352033" ], "products": [ "species_113538" ], "modifiers": [ [ "species_10490478", "catalyst" ] ], "additional_components": [ "Q8IQF3", "FBgn0052081", "Q9VLM3", "FBgn0032036", "Q9VT04", "FBgn0036007", "Q9VTD5", "FBgn0052079", "M9PEU1", "FBgn0263776", "Q9VTD7", "FBgn0036116", "M9PHT8", "FBgn0030817", "Q9VX84", "FBgn0030816", "Q4V5R4", "FBgn0033572", "Q9W056", "FBgn0035300", "Q7K2W3", "FBgn0033760" ] }, "reaction_10445129": { "compartment": "compartment_876", "id": "reaction_10445129", "reactome": "R-DME-375768", "name": "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_375765" ], "products": [ "species_375781" ], "modifiers": [ [ "species_10445126", "catalyst" ] ], "additional_components": [ "species_29444", "species_29468", "species_29468", "species_29444", "Q9VNP7", "FBgn0037203", "Q2PDY3", "FBgn0036493", "Q9VVM0", "FBgn0036764" ] }, "reaction_10444227": { "compartment": "compartment_876", "id": "reaction_10444227", "reactome": "R-DME-352158", "name": "SLC16A10-mediated uptake of aromatic amino acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352161" ], "products": [ "species_352139" ], "modifiers": [ [ "species_10444224", "catalyst" ] ], "additional_components": [ "species_29500", "species_29506", "species_29502", "species_29506", "species_29500", "species_29502", "FBgn0001296" ] }, "reaction_10431078": { "compartment": "compartment_7660", "id": "reaction_10431078", "reactome": "R-DME-73757", "name": "Binding of RRN3 to RNA Polymerase I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431074", "species_10431069" ], "products": [ "species_10431076" ], "modifiers": [], "additional_components": [ "FBgn0032988", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9V9M6", "FBgn0032988" ] }, "reaction_10431182": { "compartment": "compartment_7660", "id": "reaction_10431182", "reactome": "R-DME-73769", "name": "Loss of Rrn3 from RNA Polymerase I promoter escape complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431176" ], "products": [ "species_10431074", "species_10431180" ], "modifiers": [], "additional_components": [ "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9V9M6", "FBgn0032988", "Q9VH20", "FBgn0037792", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "FBgn0032988", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9VH20", "FBgn0037792", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10431966": { "compartment": "compartment_350", "id": "reaction_10431966", "reactome": "R-DME-74986", "name": "Elongation of pre-rRNA transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74985", "species_30595" ], "products": [ "species_74985" ], "modifiers": [ [ "species_10431180", "catalyst" ] ], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "Q6IGE3", "FBgn0262954", "P20028", "FBgn0003278", "Q9VD81", "FBgn0038903", "Q9VNZ3", "FBgn0037121", "Q9VM72", "FBgn0042092", "Q9VE94", "FBgn0038601", "Q9VC49", "FBgn0039218", "P91875", "FBgn0019938", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "Q9VH20", "FBgn0037792", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10457357": { "compartment": "compartment_70101", "id": "reaction_10457357", "reactome": "R-DME-984689", "name": "Kinesin-7 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457269" ], "products": [ "species_10457271" ], "modifiers": [], "additional_components": [ "FBgn0040232", "Q9VKI0", "FBgn0040232" ] }, "reaction_10457355": { "compartment": "compartment_70101", "id": "reaction_10457355", "reactome": "R-DME-984671", "name": "Chromokinesins form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450203" ], "products": [ "species_10457237" ], "modifiers": [], "additional_components": [ "FBgn0011606", "Q9XZ29", "FBgn0011606" ] }, "reaction_10457353": { "compartment": "compartment_70101", "id": "reaction_10457353", "reactome": "R-DME-984648", "name": "Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457250", "species_10457255" ], "products": [ "species_10457257" ], "modifiers": [], "additional_components": [ "Q9VZF5", "FBgn0011692", "FBgn0086356", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692" ] }, "reaction_10457208": { "compartment": "compartment_70101", "id": "reaction_10457208", "reactome": "R-DME-983194", "name": "Kinesin-1 is a heterotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457202", "species_10457191" ], "products": [ "species_10457206" ], "modifiers": [], "additional_components": [ "FBgn0001308", "FBgn0010235", "P46824", "FBgn0010235", "P17210", "FBgn0001308" ] }, "reaction_10457351": { "compartment": "compartment_70101", "id": "reaction_10457351", "reactome": "R-DME-984606", "name": "Kinesin-5 is a homotetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457242" ], "products": [ "species_10457244" ], "modifiers": [], "additional_components": [ "FBgn0004378", "P46863", "FBgn0004378" ] }, "reaction_10457365": { "compartment": "compartment_70101", "id": "reaction_10457365", "reactome": "R-DME-990489", "name": "Kinesin-13 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457363" ], "products": [ "species_10457311" ], "modifiers": [], "additional_components": [ "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268" ] }, "reaction_10457349": { "compartment": "compartment_70101", "id": "reaction_10457349", "reactome": "R-DME-983259", "name": "Kinesins move along microtubules consuming ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457347", "species_113592" ], "products": [ "species_10457347", "species_29370" ], "modifiers": [], "additional_components": [ "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379", "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379" ] }, "reaction_10457361": { "compartment": "compartment_70101", "id": "reaction_10457361", "reactome": "R-DME-984733", "name": "Kinesin-3 is a dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457359" ], "products": [ "species_10457233" ], "modifiers": [], "additional_components": [ "Q9VRK9", "FBgn0004380", "Q9VRK9", "FBgn0004380" ] }, "reaction_10450651": { "compartment": "compartment_70101", "id": "reaction_10450651", "reactome": "R-DME-448702", "name": "Caspase-1 active tetramer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450627" ], "products": [ "species_10450649" ], "modifiers": [], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd" ] }, "reaction_10450629": { "compartment": "compartment_70101", "id": "reaction_10450629", "reactome": "R-DME-448673", "name": "Formation of caspase-1 p10/p20 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450625", "species_10450619" ], "products": [ "species_10450627" ], "modifiers": [], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd" ] }, "reaction_10442686": { "compartment": "compartment_70101", "id": "reaction_10442686", "reactome": "R-DME-209063", "name": "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442681", "species_10426987" ], "products": [ "species_10442683" ], "modifiers": [ [ "species_10442677", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10451597": { "compartment": "compartment_70101", "id": "reaction_10451597", "reactome": "R-DME-451418", "name": "Pellino ubiquitinates IRAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451588" ], "products": [ "species_10451594" ], "modifiers": [ [ "species_10451588", "catalyst" ] ], "additional_components": [ "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "O77237", "FBgn0025574", "O77237", "FBgn0025574", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "O77237", "FBgn0025574" ] }, "reaction_10442695": { "compartment": "compartment_70101", "id": "reaction_10442695", "reactome": "R-DME-209125", "name": "SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442677", "species_10442679" ], "products": [ "species_10442681" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10442693": { "compartment": "compartment_70101", "id": "reaction_10442693", "reactome": "R-DME-209087", "name": "IKBA is phosphorylated by Phospho IKKB kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437415" ], "products": [ "species_29370", "species_10437421" ], "modifiers": [ [ "species_10442690", "catalyst" ] ], "additional_components": [] }, "reaction_10450611": { "compartment": "compartment_70101", "id": "reaction_10450611", "reactome": "R-DME-446877", "name": "TRAF6 is K63 poly-ubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450601" ], "products": [ "species_10450608" ], "modifiers": [ [ "species_10450601", "catalyst" ] ], "additional_components": [ "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "Q9W3I9", "FBgn0265464", "Q9W3I9", "FBgn0265464", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRL1", "Uev1A", "Q9W3I9", "FBgn0265464" ] }, "reaction_10442673": { "compartment": "compartment_70101", "id": "reaction_10442673", "reactome": "R-DME-209061", "name": "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442671" ], "products": [ "species_10437411", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "Q03017", "phospho-cact", "P98149", "Dif", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10495861": { "compartment": "compartment_984", "id": "reaction_10495861", "reactome": "R-DME-9008043", "name": "MAPK8 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437423" ], "products": [ "species_29370", "species_10437429" ], "modifiers": [], "additional_components": [] }, "reaction_10496003": { "compartment": "compartment_70101", "id": "reaction_10496003", "reactome": "R-DME-9009072", "name": "STAT3 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10445855" ], "products": [ "species_29370", "species_10495728" ], "modifiers": [], "additional_components": [] }, "reaction_10495919": { "compartment": "compartment_70101", "id": "reaction_10495919", "reactome": "R-DME-9008684", "name": "TBK1 phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10455277" ], "products": [ "species_10495917", "species_29370" ], "modifiers": [], "additional_components": [ "FBgn0086657", "FBgn0086657" ] }, "reaction_10460539": { "compartment": "compartment_161320", "id": "reaction_10460539", "reactome": "R-DME-1605736", "name": "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605716", "species_1605715" ], "products": [ "species_1605637", "species_1605601" ], "modifiers": [ [ "species_10460536", "catalyst" ] ], "additional_components": [ "Q7K127", "FBgn0034117", "Q9VL27", "FBgn0032192" ] }, "reaction_10460569": { "compartment": "compartment_876", "id": "reaction_10460569", "reactome": "R-DME-1606273", "name": "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429776" ], "products": [ "species_429807", "species_1610735" ], "modifiers": [ [ "species_10460566", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VZS6", "FBgn0035421" ] }, "reaction_10460472": { "compartment": "compartment_17938", "id": "reaction_10460472", "reactome": "R-DME-1605591", "name": "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605592" ], "products": [ "species_1605745", "species_1605673" ], "modifiers": [ [ "species_10460469", "catalyst" ] ], "additional_components": [ "Q9Y125", "FBgn0000416", "Q8IMY3", "FBgn0051414" ] }, "reaction_10460822": { "compartment": "compartment_876", "id": "reaction_10460822", "reactome": "R-DME-1638845", "name": "CERK phosphorylates CERA to form C1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429807", "species_113592" ], "products": [ "species_29370", "species_1638840" ], "modifiers": [ [ "species_10460819", "catalyst" ] ], "additional_components": [ "FBgn0037315" ] }, "reaction_10460591": { "compartment": "compartment_876", "id": "reaction_10460591", "reactome": "R-DME-1606583", "name": "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429807" ], "products": [ "species_1606609", "species_1861754" ], "modifiers": [ [ "species_10460588", "catalyst" ] ], "additional_components": [] }, "reaction_10460814": { "compartment": "compartment_20699", "id": "reaction_10460814", "reactome": "R-DME-1638104", "name": "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_744227", "species_428270" ], "products": [ "species_1660674", "species_205687" ], "modifiers": [ [ "species_10460811", "catalyst" ] ], "additional_components": [ "FBgn0067102" ] }, "reaction_10461805": { "compartment": "compartment_70101", "id": "reaction_10461805", "reactome": "R-DME-1861789", "name": "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861764" ], "products": [ "species_194377", "species_70113" ], "modifiers": [ [ "species_10461802", "catalyst" ] ], "additional_components": [ "FBgn0036659" ] }, "reaction_10491828": { "compartment": "compartment_17963", "id": "reaction_10491828", "reactome": "R-DME-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_8879102" ], "products": [ "species_8879101", "species_205687" ], "modifiers": [ [ "species_10491825", "catalyst" ] ], "additional_components": [ "FBgn0000221" ] }, "reaction_10460522": { "compartment": "compartment_161320", "id": "reaction_10460522", "reactome": "R-DME-1605632", "name": "Both hexosaminidase A and B can cleave GalNAc from globoside", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605608" ], "products": [ "species_1605716", "species_1605658" ], "modifiers": [ [ "species_10460519", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10471658": { "compartment": "compartment_70101", "id": "reaction_10471658", "reactome": "R-DME-5339535", "name": "GLTPD1 transports C1P from plasma membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1638840" ], "products": [ "species_5339515" ], "modifiers": [ [ "species_10471655", "catalyst" ] ], "additional_components": [ "FBgn0050392" ] }, "reaction_10461800": { "compartment": "compartment_876", "id": "reaction_10461800", "reactome": "R-DME-1861788", "name": "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1861782" ], "products": [ "species_429807", "species_70113" ], "modifiers": [ [ "species_10461797", "catalyst" ] ], "additional_components": [ "FBgn0028916" ] }, "reaction_10460581": { "compartment": "compartment_161320", "id": "reaction_10460581", "reactome": "R-DME-1606312", "name": "Beta-galactosidase can also hydrolyse globosides to form cerebrosides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605601" ], "products": [ "species_1605637", "species_1605592" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_10460644": { "compartment": "compartment_17957", "id": "reaction_10460644", "reactome": "R-DME-1614362", "name": "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_194653", "species_10460622" ], "products": [ "species_10460641", "species_1663154", "species_194697" ], "modifiers": [ [ "species_10460596", "catalyst" ] ], "additional_components": [ "Q8SZ72", "FBgn0033763", "Q8IQS4", "FBgn0052191", "Q9VVM4", "FBgn0036768", "Q9VVM1", "FBgn0036765", "Q8SZ72", "FBgn0033763", "Q9VVM4", "FBgn0036768", "Q9VVM1", "FBgn0036765", "Q8IQS4", "FBgn0052191", "FBgn0035102" ] }, "reaction_10460547": { "compartment": "compartment_161320", "id": "reaction_10460547", "reactome": "R-DME-1605797", "name": "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605713" ], "products": [ "species_1605750", "species_1605673" ], "modifiers": [ [ "species_10460544", "catalyst" ] ], "additional_components": [ "FBgn0034997" ] }, "reaction_10460579": { "compartment": "compartment_17957", "id": "reaction_10460579", "reactome": "R-DME-1606288", "name": "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_1606283" ], "products": [ "species_428256", "species_1606280" ], "modifiers": [ [ "species_10460576", "catalyst" ] ], "additional_components": [ "Q9VGH0", "FBgn0037958", "species_29926" ] }, "reaction_10471683": { "compartment": "compartment_876", "id": "reaction_10471683", "reactome": "R-DME-5340320", "name": "GLTP transports GSL from plasma membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5340315" ], "products": [ "species_5340299" ], "modifiers": [ [ "species_10471680", "catalyst" ] ], "additional_components": [ "FBgn0030641" ] }, "reaction_10479745": { "compartment": "compartment_70101", "id": "reaction_10479745", "reactome": "R-DME-6785933", "name": "UGT8 transfers Gal from UDP-Gal to CERA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452", "species_429807" ], "products": [ "species_6785915", "species_110096" ], "modifiers": [ [ "species_10479742", "catalyst" ] ], "additional_components": [ "FBgn0040257" ] }, "reaction_10460480": { "compartment": "compartment_161320", "id": "reaction_10460480", "reactome": "R-DME-1605624", "name": "Beta-galactosidase hydrolyses GM1 to GM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_1605677" ], "products": [ "species_1605637", "species_1605610" ], "modifiers": [ [ "species_10460477", "catalyst" ] ], "additional_components": [ "FBgn0260746" ] }, "reaction_209094": { "compartment": "compartment_70101", "id": "reaction_209094", "reactome": "R-DME-209094", "name": "Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex'", "reversible": "false", "notes": "The bound and phosphorylated Armadillo (ARM) is ubiquitated by the ubiquitin ligase assembled complex, whether this occurs when ARM is bound to the 'destruction complex' or after it has dissociated from it is unclear. The interaction between Slimb (SLMB) and ARM has weakened the latter's binding to the scaffolding molecules in the 'destruction complex'. ARM and the bound ubiquitin ligase assembled complex dissociate from Axin (AXN), APC (APC/APC2) and also from each other to leave free ubiquitinated and phosphorylated ARM which is now marked for degradation by the 26S proteasome.", "reactants": [ "species_206204", "species_207002" ], "products": [ "species_206991", "species_206602", "species_206788" ], "modifiers": [ [ "species_207002", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P18824", "arm", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209129": { "compartment": "compartment_70101", "id": "reaction_209129", "reactome": "R-DME-209129", "name": "Ubiquitinated and phosphorylated ARM binds to and is degraded by the proteasome complex", "reversible": "false", "notes": "The free ubiquitinated and phosphorylated Armadillo (ARM) is now targeted by the 26S proteasome which binds and then degrades it. The cytoplasmic concentration of Armadillo is now reduced.", "reactants": [ "species_206991" ], "products": [ "species_206204" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "P18824", "arm", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_209102": { "compartment": "compartment_70101", "id": "reaction_209102", "reactome": "R-DME-209102", "name": "SLMB binds to phosphorylated ARM to form the 'destruction complex'", "reversible": "false", "notes": "The phosphorylated Armadillo (ARM) is now recognised and bound by the F-box protein Slimb (SLMB), in the E3 ubiquitin ligase assembled complex additionally containing the S-phase kinase-associated protein SKPA, the Cullin orthologue, LIN19, the Ring-box protein containg ROC1A, and the ubiquitin-conjugating enzyme orthologue EFF.", "reactants": [ "species_206788", "species_207028" ], "products": [ "species_207002" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "Q24311", "Cul1", "O44382", "SLMB", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P25867", "eff", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_10459100": { "compartment": "compartment_7660", "id": "reaction_10459100", "reactome": "R-DME-1363314", "name": "p107 (RBL1) binds CyclinE/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458007", "species_10459084" ], "products": [ "species_10459098" ], "modifiers": [], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q24472", "Rbf" ] }, "reaction_10458025": { "compartment": "compartment_7660", "id": "reaction_10458025", "reactome": "R-DME-1227671", "name": "Recruitment of HDAC1 by p107 (RBL1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458009", "species_10457450" ], "products": [ "species_10458023" ], "modifiers": [], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q94517", "HDAC1", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10459096": { "compartment": "compartment_7660", "id": "reaction_10459096", "reactome": "R-DME-1363311", "name": "p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458009", "species_10459084" ], "products": [ "species_10459094" ], "modifiers": [], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10458999": { "compartment": "compartment_7660", "id": "reaction_10458999", "reactome": "R-DME-1362261", "name": "p130 (RBL2) associates with MuvB to form DREAM complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458995", "species_10457963" ], "products": [ "species_10458997" ], "modifiers": [], "additional_components": [ "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979" ] }, "reaction_10458021": { "compartment": "compartment_7660", "id": "reaction_10458021", "reactome": "R-DME-1227670", "name": "Recruitment of HDAC1 by p130 (RBL2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457450", "species_10457963" ], "products": [ "species_10458019" ], "modifiers": [], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q94517", "HDAC1" ] }, "reaction_10459092": { "compartment": "compartment_7660", "id": "reaction_10459092", "reactome": "R-DME-1363306", "name": "p130 (RBL2) binds Cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457947", "species_10459084" ], "products": [ "species_10459090" ], "modifiers": [], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9VF04", "FBgn0038390", "Q24472", "Rbf" ] }, "reaction_10459011": { "compartment": "compartment_7660", "id": "reaction_10459011", "reactome": "R-DME-1362270", "name": "Phosphorylation of LIN52 component of MuvB by DYRK1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10459003" ], "products": [ "species_113582", "species_10458995" ], "modifiers": [ [ "species_10459008", "catalyst" ] ], "additional_components": [ "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979", "Q7K159", "FBgn0034430", "Q9W482", "FBgn0029800", "Q9W542", "FBgn0023509", "A1Z9E2", "FBgn0033846", "Q24572", "FBgn0263979", "FBgn0259168" ] }, "reaction_10459088": { "compartment": "compartment_7660", "id": "reaction_10459088", "reactome": "R-DME-1363303", "name": "p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457963", "species_10459084" ], "products": [ "species_10459086" ], "modifiers": [], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10439374": { "compartment": "compartment_13231", "id": "reaction_10439374", "reactome": "R-DME-187506", "name": "Translocation of p27 to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439372" ], "products": [ "species_10427755" ], "modifiers": [], "additional_components": [ "FBgn0010316", "FBgn0010316" ] }, "reaction_10439484": { "compartment": "compartment_7660", "id": "reaction_10439484", "reactome": "R-DME-188350", "name": "CAK-mediated phosphorylation of Cyclin E:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427716" ], "products": [ "species_113582", "species_10427482" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10440842": { "compartment": "compartment_70101", "id": "reaction_10440842", "reactome": "R-DME-198613", "name": "AKT phosphorylates p21Cip1 and p27Kip1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10439372" ], "products": [ "species_29370", "species_10440840" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0010316", "FBgn0010316" ] }, "reaction_10435622": { "compartment": "compartment_13231", "id": "reaction_10435622", "reactome": "R-DME-157906", "name": "Translocation of Cyclin E:Cdk2 complex to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427710" ], "products": [ "species_10427716" ], "modifiers": [], "additional_components": [ "P54733", "FBgn0010382", "P23573", "FBgn0004107", "P23573", "FBgn0004107" ] }, "reaction_10439404": { "compartment": "compartment_7660", "id": "reaction_10439404", "reactome": "R-DME-187575", "name": "Ubiquitination of phospho-p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439395", "species_10427430" ], "products": [ "species_10439399" ], "modifiers": [ [ "species_10439395", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10439401": { "compartment": "compartment_7660", "id": "reaction_10439401", "reactome": "R-DME-187574", "name": "Degradation of ubiquitinated p27/p21 by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439399" ], "products": [ "species_10439393", "species_10427430", "species_10427484" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10439384": { "compartment": "compartment_7660", "id": "reaction_10439384", "reactome": "R-DME-187520", "name": "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439376", "species_29358" ], "products": [ "species_113582", "species_10439381" ], "modifiers": [ [ "species_10439376", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316" ] }, "reaction_10439397": { "compartment": "compartment_7660", "id": "reaction_10439397", "reactome": "R-DME-187552", "name": "Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439393", "species_10439381" ], "products": [ "species_10439395" ], "modifiers": [], "additional_components": [ "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "Q7JNL9", "FBgn0010316", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10427729": { "compartment": "compartment_7660", "id": "reaction_10427729", "reactome": "R-DME-69195", "name": "Phosphorylation of Cyclin E:CDK2 complexes by WEE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427716" ], "products": [ "species_113582", "species_10427721" ], "modifiers": [ [ "species_10427726", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "P54733", "FBgn0010382", "FBgn0011737" ] }, "reaction_10427712": { "compartment": "compartment_70101", "id": "reaction_10427712", "reactome": "R-DME-69191", "name": "Formation of Cyclin E:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427704", "species_10427706" ], "products": [ "species_10427710" ], "modifiers": [], "additional_components": [ "FBgn0004107", "FBgn0010382", "P54733", "FBgn0010382", "P23573", "FBgn0004107" ] }, "reaction_10427760": { "compartment": "compartment_7660", "id": "reaction_10427760", "reactome": "R-DME-69562", "name": "Inactivation of Cyclin E:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427716", "species_10427755" ], "products": [ "species_10427757" ], "modifiers": [ [ "species_10427755", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "FBgn0010316", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "FBgn0010316" ] }, "reaction_10427744": { "compartment": "compartment_7660", "id": "reaction_10427744", "reactome": "R-DME-69199", "name": "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10427721" ], "products": [ "species_113550", "species_10427716" ], "modifiers": [ [ "species_10427741", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P54733", "FBgn0010382", "P23573", "FBgn0004107", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10427470": { "compartment": "compartment_7660", "id": "reaction_10427470", "reactome": "R-DME-68960", "name": "DNA polymerase epsilon binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68419", "species_10427294" ], "products": [ "species_10427296" ], "modifiers": [ [ "species_10427363", "catalyst" ] ], "additional_components": [ "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427372": { "compartment": "compartment_7660", "id": "reaction_10427372", "reactome": "R-DME-68918", "name": "CDK and DDK associate with the Mcm10:pre-replicative complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427348", "species_10427336", "species_10427357" ], "products": [ "species_10427359" ], "modifiers": [], "additional_components": [ "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "P23573", "FBgn0004107", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427468": { "compartment": "compartment_7660", "id": "reaction_10427468", "reactome": "R-DME-68954", "name": "Mcm2-7 is phosphorylated by DDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427244" ], "products": [ "species_113582", "species_10427465" ], "modifiers": [ [ "species_10427348", "catalyst" ] ], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "species_29372", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427370": { "compartment": "compartment_7660", "id": "reaction_10427370", "reactome": "R-DME-68917", "name": "Cdc45 associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427359", "species_10427327" ], "products": [ "species_10427361" ], "modifiers": [], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "FBgn0026143", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427368": { "compartment": "compartment_7660", "id": "reaction_10427368", "reactome": "R-DME-68916", "name": "DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427361", "species_10427322" ], "products": [ "species_10427363" ], "modifiers": [], "additional_components": [ "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427750": { "compartment": "compartment_7660", "id": "reaction_10427750", "reactome": "R-DME-69299", "name": "Cdt1 associates with geminin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427746", "species_10427208" ], "products": [ "species_10427748" ], "modifiers": [], "additional_components": [ "FBgn0033081", "FBgn0000996", "Q7JVY2", "FBgn0000996", "Q7JX41", "FBgn0033081" ] }, "reaction_10427365": { "compartment": "compartment_7660", "id": "reaction_10427365", "reactome": "R-DME-68914", "name": "DNA polymerase alpha:primase binds at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427296", "species_10427272" ], "products": [ "species_10427298" ], "modifiers": [ [ "species_10427363", "catalyst" ] ], "additional_components": [ "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10427378": { "compartment": "compartment_7660", "id": "reaction_10427378", "reactome": "R-DME-68940", "name": "Cdt1 is displaced from the pre-replicative complex.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427374" ], "products": [ "species_10427208", "species_10427357" ], "modifiers": [], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "FBgn0000996", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929" ] }, "reaction_10427376": { "compartment": "compartment_7660", "id": "reaction_10427376", "reactome": "R-DME-68919", "name": "Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427353", "species_10427246" ], "products": [ "species_10427374" ], "modifiers": [], "additional_components": [ "FBgn0032929", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929" ] }, "reaction_10493217": { "compartment": "compartment_70101", "id": "reaction_10493217", "reactome": "R-DME-8941895", "name": "Formation of CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487898", "species_10432397" ], "products": [ "species_10487900" ], "modifiers": [], "additional_components": [ "FBgn0010315", "FBgn0016131", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10493286": { "compartment": "compartment_13231", "id": "reaction_10493286", "reactome": "R-DME-8942803", "name": "Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493276" ], "products": [ "species_10493284" ], "modifiers": [], "additional_components": [ "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7JNL9", "FBgn0010316" ] }, "reaction_10493223": { "compartment": "compartment_70101", "id": "reaction_10493223", "reactome": "R-DME-8941915", "name": "Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487900", "species_10439372" ], "products": [ "species_10493221" ], "modifiers": [], "additional_components": [ "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "FBgn0010316", "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10459080": { "compartment": "compartment_7660", "id": "reaction_10459080", "reactome": "R-DME-1363276", "name": "Dephosphorylation of p130 (RBL2) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10457975" ], "products": [ "species_113550", "species_10457947" ], "modifiers": [ [ "species_10459075", "catalyst" ] ], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q9VF04", "FBgn0038390", "Q24472", "Rbf" ] }, "reaction_10493288": { "compartment": "compartment_7660", "id": "reaction_10493288", "reactome": "R-DME-8942836", "name": "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10493284" ], "products": [ "species_113582", "species_10458002" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7JNL9", "FBgn0010316", "Q7JNL9", "FBgn0010316", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10459078": { "compartment": "compartment_7660", "id": "reaction_10459078", "reactome": "R-DME-1363274", "name": "Dephosphorylation of p107 (RBL1) by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10458015" ], "products": [ "species_113550", "species_10458007" ], "modifiers": [ [ "species_10459075", "catalyst" ] ], "additional_components": [] }, "reaction_10493274": { "compartment": "compartment_70101", "id": "reaction_10493274", "reactome": "R-DME-8942607", "name": "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10493221" ], "products": [ "species_29370", "species_10493251" ], "modifiers": [ [ "species_10493271", "catalyst" ] ], "additional_components": [ "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7JNL9", "FBgn0010316", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10458005": { "compartment": "compartment_7660", "id": "reaction_10458005", "reactome": "R-DME-1226094", "name": "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10457963" ], "products": [ "species_113582", "species_10457975", "species_10457977" ], "modifiers": [ [ "species_10458002", "catalyst" ] ], "additional_components": [ "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q7JNL9", "FBgn0010316", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10459109": { "compartment": "compartment_7660", "id": "reaction_10459109", "reactome": "R-DME-1363331", "name": "Ubiquitination of p130 (RBL2) by SCF (Skp2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10459102" ], "products": [ "species_10439393", "species_10459106" ], "modifiers": [ [ "species_10459102", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10458017": { "compartment": "compartment_7660", "id": "reaction_10458017", "reactome": "R-DME-1226095", "name": "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10458009" ], "products": [ "species_113582", "species_10457977", "species_10458015" ], "modifiers": [ [ "species_10458002", "catalyst" ] ], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "Q7JNL9", "FBgn0010316", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10459104": { "compartment": "compartment_7660", "id": "reaction_10459104", "reactome": "R-DME-1363328", "name": "Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439393", "species_10457975" ], "products": [ "species_10459102" ], "modifiers": [], "additional_components": [ "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "Q9VF04", "FBgn0038390", "Q24472", "Rbf", "O77430", "SkpA", "Q24311", "Cul1", "Q24152", "FBgn0010314" ] }, "reaction_10439450": { "compartment": "compartment_7660", "id": "reaction_10439450", "reactome": "R-DME-187937", "name": "Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426928", "species_10427405" ], "products": [ "species_10439448" ], "modifiers": [], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q27368", "phospho-E2f1" ] }, "reaction_10439464": { "compartment": "compartment_7660", "id": "reaction_10439464", "reactome": "R-DME-187959", "name": "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10439448" ], "products": [ "species_113582", "species_10439461" ], "modifiers": [ [ "species_10439448", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "Q27368", "phospho-E2f1", "P23573", "FBgn0004107", "Q27368", "phospho-E2f1", "P23573", "FBgn0004107", "Q27368", "phospho-E2f1" ] }, "reaction_10437631": { "compartment": "compartment_13231", "id": "reaction_10437631", "reactome": "R-DME-170072", "name": "Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437595" ], "products": [ "species_10437575" ], "modifiers": [ [ "species_10437629", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "FBgn0020497" ] }, "reaction_10437726": { "compartment": "compartment_70101", "id": "reaction_10437726", "reactome": "R-DME-170161", "name": "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10437719" ], "products": [ "species_29372", "species_10437723" ], "modifiers": [ [ "species_10437671", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437692": { "compartment": "compartment_13231", "id": "reaction_10437692", "reactome": "R-DME-170149", "name": "Translocation of active Cdc25C to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435511" ], "products": [ "species_10437690" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437659": { "compartment": "compartment_13231", "id": "reaction_10437659", "reactome": "R-DME-170088", "name": "Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437657" ], "products": [ "species_10437651" ], "modifiers": [], "additional_components": [ "P23572", "FBgn0004106", "P23572", "FBgn0004106" ] }, "reaction_10437624": { "compartment": "compartment_7660", "id": "reaction_10437624", "reactome": "R-DME-170070", "name": "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437622" ], "products": [ "species_113582", "species_10437595" ], "modifiers": [ [ "species_10427726", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "FBgn0011737" ] }, "reaction_10437655": { "compartment": "compartment_7660", "id": "reaction_10437655", "reactome": "R-DME-170087", "name": "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437651" ], "products": [ "species_113582", "species_10437653" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P23572", "FBgn0004106", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10437684": { "compartment": "compartment_13231", "id": "reaction_10437684", "reactome": "R-DME-170131", "name": "Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437583" ], "products": [ "species_10437601" ], "modifiers": [], "additional_components": [ "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10489387": { "compartment": "compartment_7660", "id": "reaction_10489387", "reactome": "R-DME-8856945", "name": "PP2A methylation by LCMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10459075" ], "products": [ "species_77502", "species_10489379" ], "modifiers": [ [ "species_10489384", "catalyst" ] ], "additional_components": [ "FBgn0028507" ] }, "reaction_10437715": { "compartment": "compartment_13231", "id": "reaction_10437715", "reactome": "R-DME-170159", "name": "Translocation of Cdc25 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437713" ], "products": [ "species_10437696" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437618": { "compartment": "compartment_70101", "id": "reaction_10437618", "reactome": "R-DME-170057", "name": "Formation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437568", "species_10437609" ], "products": [ "species_10437611" ], "modifiers": [], "additional_components": [ "FBgn0000405", "FBgn0004106", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10437682": { "compartment": "compartment_70101", "id": "reaction_10437682", "reactome": "R-DME-170126", "name": "Phosphorylation of Cyclin B1 in the CRS domain", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437675" ], "products": [ "species_29370", "species_10437583" ], "modifiers": [ [ "species_10437679", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P20439", "FBgn0000405", "P23572", "FBgn0004106" ] }, "reaction_10437649": { "compartment": "compartment_70101", "id": "reaction_10437649", "reactome": "R-DME-170084", "name": "Formation of Cyclin A:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437609", "species_10437645" ], "products": [ "species_10437647" ], "modifiers": [], "additional_components": [ "FBgn0004106", "P23572", "FBgn0004106" ] }, "reaction_10437616": { "compartment": "compartment_70101", "id": "reaction_10437616", "reactome": "R-DME-170055", "name": "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437611" ], "products": [ "species_10437570", "species_29370" ], "modifiers": [ [ "species_10437613", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "FBgn0040298" ] }, "reaction_10489395": { "compartment": "compartment_7660", "id": "reaction_10489395", "reactome": "R-DME-8856951", "name": "PP2A demethylation by PPME1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10489379" ], "products": [ "species_10459075", "species_8857797" ], "modifiers": [ [ "species_10489392", "catalyst" ] ], "additional_components": [ "FBgn0035951" ] }, "reaction_10437705": { "compartment": "compartment_7660", "id": "reaction_10437705", "reactome": "R-DME-170158", "name": "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10437701" ], "products": [ "species_113550", "species_10437703" ], "modifiers": [ [ "species_10427741", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P23572", "FBgn0004106", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437673": { "compartment": "compartment_13231", "id": "reaction_10437673", "reactome": "R-DME-170120", "name": "Translocation of Cdc25B to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437665" ], "products": [ "species_10437671" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10437605": { "compartment": "compartment_13231", "id": "reaction_10437605", "reactome": "R-DME-170044", "name": "Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437585" ], "products": [ "species_10437603" ], "modifiers": [], "additional_components": [ "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10437635": { "compartment": "compartment_7660", "id": "reaction_10437635", "reactome": "R-DME-170076", "name": "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437591" ], "products": [ "species_113582", "species_10437622" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10437699": { "compartment": "compartment_7660", "id": "reaction_10437699", "reactome": "R-DME-170153", "name": "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10437595" ], "products": [ "species_113550", "species_10437694" ], "modifiers": [ [ "species_10437696", "catalyst" ] ], "additional_components": [ "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10435532": { "compartment": "compartment_7660", "id": "reaction_10435532", "reactome": "R-DME-156699", "name": "Inactivation of Wee1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427726" ], "products": [ "species_113582", "species_10435530" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0011737", "FBgn0011737", "FBgn0003124" ] }, "reaction_10435516": { "compartment": "compartment_7660", "id": "reaction_10435516", "reactome": "R-DME-156678", "name": "Activation of Cdc25C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10435503" ], "products": [ "species_29370", "species_10435511" ], "modifiers": [ [ "species_10435513", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0003124" ] }, "reaction_10435996": { "compartment": "compartment_7660", "id": "reaction_10435996", "reactome": "R-DME-162657", "name": "Inactivation of Myt1 kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10435991" ], "products": [ "species_113582", "species_10435994" ], "modifiers": [ [ "species_10435494", "catalyst" ] ], "additional_components": [ "FBgn0040298", "FBgn0040298", "FBgn0003124" ] }, "reaction_10488880": { "compartment": "compartment_70101", "id": "reaction_10488880", "reactome": "R-DME-8854041", "name": "SCF-FBXL7 ubiquitinates AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488823", "species_10426987" ], "products": [ "species_10488877" ], "modifiers": [ [ "species_10488823", "catalyst" ] ], "additional_components": [ "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147" ] }, "reaction_10488882": { "compartment": "compartment_70101", "id": "reaction_10488882", "reactome": "R-DME-8854044", "name": "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488877" ], "products": [ "species_10488821", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10488825": { "compartment": "compartment_70101", "id": "reaction_10488825", "reactome": "R-DME-8853496", "name": "SCF:FBXL7 binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438226", "species_10488821" ], "products": [ "species_10488823" ], "modifiers": [], "additional_components": [ "FBgn0000147", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VGF9", "FBgn0000147" ] }, "reaction_10488890": { "compartment": "compartment_70101", "id": "reaction_10488890", "reactome": "R-DME-8854051", "name": "SCF-FBXL18 ubiquitinates FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456346", "species_10426987" ], "products": [ "species_10488885" ], "modifiers": [ [ "species_10488887", "catalyst" ] ], "additional_components": [ "FBgn0038385", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236" ] }, "reaction_10488892": { "compartment": "compartment_70101", "id": "reaction_10488892", "reactome": "R-DME-8854052", "name": "Formation of the SCF-FBXL7 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442675", "species_10438327", "species_10438329", "species_10456346" ], "products": [ "species_10488821" ], "modifiers": [], "additional_components": [ "FBgn0038385", "Q9VF10", "FBgn0038385", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10488894": { "compartment": "compartment_70101", "id": "reaction_10488894", "reactome": "R-DME-8854071", "name": "Proteasome-mediated degradation of PolyUb-FBXL7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488885" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0038385", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10469628": { "compartment": "compartment_70101", "id": "reaction_10469628", "reactome": "R-DME-4086410", "name": "CDK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469626" ], "products": [ "species_29370", "species_10467358" ], "modifiers": [ [ "species_10437723", "catalyst" ] ], "additional_components": [ "FBgn0259791", "FBgn0259791", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10467367": { "compartment": "compartment_70101", "id": "reaction_10467367", "reactome": "R-DME-3000327", "name": "PLK1 phosphorylates BORA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467360", "species_113592" ], "products": [ "species_10467364", "species_29370", "species_10435513" ], "modifiers": [ [ "species_10467360", "catalyst" ] ], "additional_components": [ "Q9VVR2", "FBgn0259791", "P52304", "FBgn0003124", "FBgn0259791", "FBgn0003124", "Q9VVR2", "FBgn0259791", "P52304", "FBgn0003124" ] }, "reaction_10467399": { "compartment": "compartment_7660", "id": "reaction_10467399", "reactome": "R-DME-3002811", "name": "Myosin phosphatase dephosphorylates PLK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10435494" ], "products": [ "species_113550", "species_10467382" ], "modifiers": [ [ "species_10467396", "catalyst" ] ], "additional_components": [ "FBgn0003124", "FBgn0003124", "M9NEB2", "FBgn0005536", "P48462", "flw" ] }, "reaction_10467380": { "compartment": "compartment_70101", "id": "reaction_10467380", "reactome": "R-DME-3002798", "name": "Cytosolic PLK1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435513" ], "products": [ "species_10435494" ], "modifiers": [], "additional_components": [ "FBgn0003124", "FBgn0003124" ] }, "reaction_10427303": { "compartment": "compartment_7660", "id": "reaction_10427303", "reactome": "R-DME-68913", "name": "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427298", "species_30595" ], "products": [ "species_10427300", "species_10427294" ], "modifiers": [ [ "species_10427298", "catalyst" ] ], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "species_110577", "species_113592", "species_29494", "species_29438", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VCN1", "FBgn0264326", "Q9W256", "FBgn0034726", "Q9V444", "FBgn0043002", "Q9VRQ7", "FBgn0035644" ] }, "reaction_10427463": { "compartment": "compartment_7660", "id": "reaction_10427463", "reactome": "R-DME-68950", "name": "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427300", "species_30187", "species_30185", "species_29892", "species_29604" ], "products": [ "species_10427460" ], "modifiers": [ [ "species_10427272", "catalyst" ] ], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113" ] }, "reaction_10427595": { "compartment": "compartment_7660", "id": "reaction_10427595", "reactome": "R-DME-69019", "name": "Mcm4,6,7 trimer forms and associates with the replication fork", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427244" ], "products": [ "species_10427217", "species_10427593", "species_10427242", "species_10427227" ], "modifiers": [], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "FBgn0284442", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9V461", "FBgn0025815", "FBgn0014861", "FBgn0017577" ] }, "reaction_10427452": { "compartment": "compartment_7660", "id": "reaction_10427452", "reactome": "R-DME-68946", "name": "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10427382" ], "products": [ "species_10427433" ], "modifiers": [ [ "species_10427449", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0286788", "FBgn0286788", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1" ] }, "reaction_10427458": { "compartment": "compartment_70101", "id": "reaction_10427458", "reactome": "R-DME-68948", "name": "Ubiquitinated Orc1 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427454" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0286788", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10427408": { "compartment": "compartment_7660", "id": "reaction_10427408", "reactome": "R-DME-68944", "name": "Orc1 is phosphorylated by cyclin A/CDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427246" ], "products": [ "species_113582", "species_10427382", "species_10427384" ], "modifiers": [ [ "species_10427405", "catalyst" ] ], "additional_components": [ "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "FBgn0286788", "Q9VSM9", "FBgn0035918", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q7JVY2", "FBgn0000996", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "P23573", "FBgn0004107" ] }, "reaction_10427456": { "compartment": "compartment_7660", "id": "reaction_10427456", "reactome": "R-DME-68947", "name": "Ubiquitinated Orc1 enters the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427433" ], "products": [ "species_10427454" ], "modifiers": [], "additional_components": [ "FBgn0286788", "FBgn0286788" ] }, "reaction_10427487": { "compartment": "compartment_7660", "id": "reaction_10427487", "reactome": "R-DME-69005", "name": "Cdc6 protein is phosphorylated by CDK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10426924" ], "products": [ "species_113582", "species_10427473" ], "modifiers": [ [ "species_10427484", "catalyst" ] ], "additional_components": [ "FBgn0035918", "FBgn0035918", "P23573", "FBgn0004107", "P54733", "FBgn0010382" ] }, "reaction_10427591": { "compartment": "compartment_70101", "id": "reaction_10427591", "reactome": "R-DME-69016", "name": "Ubiquitinated Cdc6 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427495" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSM9", "FBgn0035918", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10427589": { "compartment": "compartment_70101", "id": "reaction_10427589", "reactome": "R-DME-69015", "name": "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427489", "species_113592", "species_10426987" ], "products": [ "species_10427495" ], "modifiers": [ [ "species_10427586", "catalyst" ] ], "additional_components": [ "FBgn0035918", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VSM9", "FBgn0035918", "Q9VS37", "FBgn0012058", "P52485", "FBgn0015320", "Q9VX25", "FBgn0030863", "Q9W1E5", "FBgn0002791", "Q9I7L8", "FBgn0032863", "Q9V831", "FBgn0034231", "Q7KA43", "FBgn0250903", "Q9W3Y6", "FBgn0029879", "Q9VXV3", "FBgn0004391", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VTY6", "FBgn0264848", "Q9W4H9", "FBgn0262699" ] }, "reaction_10427491": { "compartment": "compartment_7660", "id": "reaction_10427491", "reactome": "R-DME-69006", "name": "Phosphorylated Cdc6 is exported from the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427473" ], "products": [ "species_10427489" ], "modifiers": [], "additional_components": [ "FBgn0035918", "FBgn0035918" ] }, "reaction_10427694": { "compartment": "compartment_7660", "id": "reaction_10427694", "reactome": "R-DME-69152", "name": "Removal of remaining Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427682" ], "products": [ "species_10427686" ], "modifiers": [ [ "species_10427691", "catalyst" ] ], "additional_components": [ "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "FBgn0025832" ] }, "reaction_10427671": { "compartment": "compartment_7660", "id": "reaction_10427671", "reactome": "R-DME-69140", "name": "RPA binds to the Flap", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_10427663" ], "products": [ "species_10427669" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10427684": { "compartment": "compartment_7660", "id": "reaction_10427684", "reactome": "R-DME-69144", "name": "Removal of RNA primer and dissociation of RPA and Dna2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427678" ], "products": [ "species_418075", "species_10427682", "species_10427667", "species_164121", "species_29626", "species_418076", "species_10427676" ], "modifiers": [], "additional_components": [ "Q8IRL9", "FBgn0030170", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0030170" ] }, "reaction_10427680": { "compartment": "compartment_7660", "id": "reaction_10427680", "reactome": "R-DME-69142", "name": "Recruitment of Dna2 endonuclease", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427669", "species_10427676" ], "products": [ "species_10427678" ], "modifiers": [], "additional_components": [ "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0030170", "Q8IRL9", "FBgn0030170", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10427702": { "compartment": "compartment_7660", "id": "reaction_10427702", "reactome": "R-DME-69173", "name": "Joining of adjacent Okazaki fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_68452" ], "products": [ "species_69172" ], "modifiers": [ [ "species_10427699", "catalyst" ] ], "additional_components": [ "FBgn0262619" ] }, "reaction_10427665": { "compartment": "compartment_7660", "id": "reaction_10427665", "reactome": "R-DME-69127", "name": "Formation of the Flap Intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427661" ], "products": [ "species_10427663" ], "modifiers": [], "additional_components": [ "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "Q9W088", "FBgn0027903", "P54358", "FBgn0263600", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655" ] }, "reaction_10427626": { "compartment": "compartment_7660", "id": "reaction_10427626", "reactome": "R-DME-69053", "name": "RFC binding displaces Pol Alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427460", "species_10427622" ], "products": [ "species_10427624" ], "modifiers": [], "additional_components": [ "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113" ] }, "reaction_10427641": { "compartment": "compartment_7660", "id": "reaction_10427641", "reactome": "R-DME-69068", "name": "RFC dissociates after sliding clamp formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427635" ], "products": [ "species_10427622", "species_10427639" ], "modifiers": [], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655" ] }, "reaction_10427637": { "compartment": "compartment_7660", "id": "reaction_10427637", "reactome": "R-DME-69063", "name": "Loading of PCNA - Sliding Clamp Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427633", "species_10427624" ], "products": [ "species_113582", "species_10427635" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q9VB62", "FBgn0005696", "Q24317", "FBgn0011762", "Q9VPH2", "FBgn0259676", "P26019", "FBgn0259113", "P17917", "FBgn0005655" ] }, "reaction_10438762": { "compartment": "compartment_7660", "id": "reaction_10438762", "reactome": "R-DME-176956", "name": "Formation of GINS complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438753", "species_10438758", "species_10438743", "species_10438748" ], "products": [ "species_10438760" ], "modifiers": [], "additional_components": [ "FBgn0030196", "FBgn0039403", "FBgn0035194", "FBgn0261976", "Q9VQY9", "FBgn0261976", "Q9W0I7", "FBgn0035194", "Q9VBI1", "FBgn0039403", "Q9W2V7", "FBgn0030196" ] }, "reaction_10438063": { "compartment": "compartment_70101", "id": "reaction_10438063", "reactome": "R-DME-174054", "name": "Formation of Cyclin A:Cdk2 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427704", "species_10437645" ], "products": [ "species_10438061" ], "modifiers": [], "additional_components": [ "FBgn0004107", "P23573", "FBgn0004107" ] }, "reaction_10439454": { "compartment": "compartment_7660", "id": "reaction_10439454", "reactome": "R-DME-187949", "name": "CAK-mediated phosphorylation of Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438267" ], "products": [ "species_113582", "species_10427405" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10439452": { "compartment": "compartment_7660", "id": "reaction_10439452", "reactome": "R-DME-187948", "name": "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438212" ], "products": [ "species_113582", "species_10438066" ], "modifiers": [ [ "species_10427405", "catalyst" ] ], "additional_components": [ "FBgn0262699", "FBgn0262699", "P23573", "FBgn0004107" ] }, "reaction_10439446": { "compartment": "compartment_7660", "id": "reaction_10439446", "reactome": "R-DME-187934", "name": "Inactivation of Cyclin A:Cdk2 complexes by p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427755", "species_10438267" ], "products": [ "species_10439439" ], "modifiers": [ [ "species_10427755", "catalyst" ] ], "additional_components": [ "FBgn0010316", "P23573", "FBgn0004107", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "FBgn0010316" ] }, "reaction_10439444": { "compartment": "compartment_7660", "id": "reaction_10439444", "reactome": "R-DME-187916", "name": "Cyclin A:Cdk2 mediated phosphorylation of p27/p21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10439439" ], "products": [ "species_113582", "species_10439441" ], "modifiers": [ [ "species_10439439", "catalyst" ] ], "additional_components": [ "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q7JNL9", "FBgn0010316", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107" ] }, "reaction_10438353": { "compartment": "compartment_7660", "id": "reaction_10438353", "reactome": "R-DME-174164", "name": "Phosphorylation of Cyclin A:Cdk2 at Tyr 15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438267" ], "products": [ "species_113582", "species_10438265" ], "modifiers": [ [ "species_10427726", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "FBgn0011737" ] }, "reaction_10438384": { "compartment": "compartment_13231", "id": "reaction_10438384", "reactome": "R-DME-174273", "name": "Translocation of Cyclin A:Cdk2 complexes to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438061" ], "products": [ "species_10438267" ], "modifiers": [], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107" ] }, "reaction_10438272": { "compartment": "compartment_7660", "id": "reaction_10438272", "reactome": "R-DME-174110", "name": "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10438265" ], "products": [ "species_113550", "species_10438267" ], "modifiers": [ [ "species_10438269", "catalyst" ] ], "additional_components": [ "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10432407": { "compartment": "compartment_70101", "id": "reaction_10432407", "reactome": "R-DME-75825", "name": "Proteasome mediated degradation of Cyclin D1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432405" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7KUZ5", "FBgn0010315", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10432403": { "compartment": "compartment_13231", "id": "reaction_10432403", "reactome": "R-DME-75823", "name": "Relocalization of nuclearly localized Cyclin D1 to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432386" ], "products": [ "species_10432395" ], "modifiers": [], "additional_components": [ "FBgn0010315", "FBgn0010315" ] }, "reaction_10432401": { "compartment": "compartment_13231", "id": "reaction_10432401", "reactome": "R-DME-75822", "name": "Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432393" ], "products": [ "species_10432399" ], "modifiers": [], "additional_components": [ "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10466073": { "compartment": "compartment_7660", "id": "reaction_10466073", "reactome": "R-DME-2473152", "name": "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466069", "species_113560" ], "products": [ "species_2485002", "species_10466071" ], "modifiers": [ [ "species_10466031", "catalyst" ] ], "additional_components": [ "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9VXE9", "FBgn0015615", "FBgn0035766" ] }, "reaction_10466036": { "compartment": "compartment_7660", "id": "reaction_10466036", "reactome": "R-DME-2468039", "name": "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466018", "species_113560" ], "products": [ "species_2485002", "species_10466026" ], "modifiers": [ [ "species_10466031", "catalyst" ] ], "additional_components": [ "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VXE9", "FBgn0015615", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9W517", "FBgn0004655", "A1Z8S6", "FBgn0260012", "O96689", "FBgn0260987", "Q9VCD8", "FBgn0040283", "Q9W0F4", "FBgn0043865", "Q9VM62", "FBgn0020616", "Q9VXE9", "FBgn0015615", "FBgn0035766" ] }, "reaction_10498336": { "compartment": "compartment_70101", "id": "reaction_10498336", "reactome": "R-DME-9656947", "name": "OGG1beta translocates to mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498332" ], "products": [ "species_10498334" ], "modifiers": [], "additional_components": [ "FBgn0027864", "FBgn0027864" ] }, "reaction_10497794": { "compartment": "compartment_7660", "id": "reaction_10497794", "reactome": "R-DME-9629492", "name": "NEIL3 cleaves spiroiminodihydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497791" ], "products": [ "species_9629439", "species_10497784" ], "modifiers": [ [ "species_10497791", "catalyst" ] ], "additional_components": [ "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258" ] }, "reaction_10433945": { "compartment": "compartment_7660", "id": "reaction_10433945", "reactome": "R-DME-110243", "name": "Excision of 8-oxoguanine by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433940" ], "products": [ "species_10433942", "species_110242" ], "modifiers": [ [ "species_10433940", "catalyst" ] ], "additional_components": [ "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864" ] }, "reaction_10497787": { "compartment": "compartment_7660", "id": "reaction_10497787", "reactome": "R-DME-9629470", "name": "NEIL3 cleaves 5-guanidinohydantoin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497782" ], "products": [ "species_10497784", "species_9629218" ], "modifiers": [ [ "species_10497782", "catalyst" ] ], "additional_components": [ "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258" ] }, "reaction_10433903": { "compartment": "compartment_7660", "id": "reaction_10433903", "reactome": "R-DME-110224", "name": "Cleavage of thymine glycol by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433898" ], "products": [ "species_110223", "species_10433900" ], "modifiers": [ [ "species_10433898", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10433950": { "compartment": "compartment_7660", "id": "reaction_10433950", "reactome": "R-DME-110244", "name": "Excision of FapyG by OGG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433947" ], "products": [ "species_10433942", "species_5636006" ], "modifiers": [ [ "species_10433947", "catalyst" ] ], "additional_components": [ "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864", "Q9V3I8", "FBgn0027864" ] }, "reaction_10433917": { "compartment": "compartment_7660", "id": "reaction_10433917", "reactome": "R-DME-110227", "name": "Cleavage of dihydrouracil by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433914" ], "products": [ "species_30140", "species_10433900" ], "modifiers": [ [ "species_10433914", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10433883": { "compartment": "compartment_7660", "id": "reaction_10433883", "reactome": "R-DME-110219", "name": "Cleavage of thymine by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433880" ], "products": [ "species_10433873", "species_29692" ], "modifiers": [ [ "species_10433880", "catalyst" ] ], "additional_components": [ "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869" ] }, "reaction_10433931": { "compartment": "compartment_7660", "id": "reaction_10433931", "reactome": "R-DME-110234", "name": "Cleavage of ethenocytosine by TDG glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433928" ], "products": [ "species_10433873", "species_110233" ], "modifiers": [ [ "species_10433928", "catalyst" ] ], "additional_components": [ "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869" ] }, "reaction_10433894": { "compartment": "compartment_7660", "id": "reaction_10433894", "reactome": "R-DME-110221", "name": "Cleavage of uracil by SMUG1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433887" ], "products": [ "species_10433891", "species_29554" ], "modifiers": [ [ "species_10433887", "catalyst" ] ], "additional_components": [ "Q9VEM1", "FBgn0038490", "Q9VEM1", "FBgn0038490", "Q9VEM1", "FBgn0038490" ] }, "reaction_10433910": { "compartment": "compartment_7660", "id": "reaction_10433910", "reactome": "R-DME-110226", "name": "Cleavage of cytosine glycol by NTHL1 glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433907" ], "products": [ "species_10433900", "species_110225" ], "modifiers": [ [ "species_10433907", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10433876": { "compartment": "compartment_7660", "id": "reaction_10433876", "reactome": "R-DME-110218", "name": "Cleavage of uracil by TDG glycosylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433869" ], "products": [ "species_10433873", "species_29554" ], "modifiers": [ [ "species_10433869", "catalyst" ] ], "additional_components": [ "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869", "Q9V4D8", "FBgn0026869" ] }, "reaction_10433924": { "compartment": "compartment_7660", "id": "reaction_10433924", "reactome": "R-DME-110229", "name": "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433921" ], "products": [ "species_5637659", "species_10433900" ], "modifiers": [ [ "species_10433921", "catalyst" ] ], "additional_components": [ "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907", "Q9VIH0", "FBgn0032907" ] }, "reaction_10474548": { "compartment": "compartment_7660", "id": "reaction_10474548", "reactome": "R-DME-5649681", "name": "NEIL2 cleaves 5-OHU from damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474543" ], "products": [ "species_10474545", "species_110216" ], "modifiers": [ [ "species_10474543", "catalyst" ] ], "additional_components": [ "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258", "M9PFV8", "FBgn0261258" ] }, "reaction_10434063": { "compartment": "compartment_7660", "id": "reaction_10434063", "reactome": "R-DME-110359", "name": "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434046" ], "products": [ "species_10434060" ], "modifiers": [ [ "species_10434046", "catalyst" ] ], "additional_components": [ "P27864", "FBgn0004584", "P27864", "FBgn0004584", "P27864", "FBgn0004584" ] }, "reaction_10434056": { "compartment": "compartment_7660", "id": "reaction_10434056", "reactome": "R-DME-110354", "name": "Displacement of OGG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433942", "species_10434044" ], "products": [ "species_10433936", "species_10434046" ], "modifiers": [], "additional_components": [ "Q9V3I8", "FBgn0027864", "FBgn0004584", "FBgn0027864", "P27864", "FBgn0004584" ] }, "reaction_10434054": { "compartment": "compartment_7660", "id": "reaction_10434054", "reactome": "R-DME-110352", "name": "Displacement of NTHL1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433900", "species_10434044" ], "products": [ "species_10433865", "species_10434046" ], "modifiers": [], "additional_components": [ "Q9VIH0", "FBgn0032907", "FBgn0004584", "FBgn0032907", "P27864", "FBgn0004584" ] }, "reaction_10434052": { "compartment": "compartment_7660", "id": "reaction_10434052", "reactome": "R-DME-110351", "name": "Displacement of SMUG1 glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434050", "species_10434044" ], "products": [ "species_10433860", "species_10434046" ], "modifiers": [], "additional_components": [ "Q9VEM1", "FBgn0038490", "FBgn0004584", "FBgn0038490", "P27864", "FBgn0004584" ] }, "reaction_10434048": { "compartment": "compartment_7660", "id": "reaction_10434048", "reactome": "R-DME-110350", "name": "Displacement of TDG glycosylase by APEX1 at the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433873", "species_10434044" ], "products": [ "species_10434046", "species_10433855" ], "modifiers": [], "additional_components": [ "Q9V4D8", "FBgn0026869", "FBgn0004584", "P27864", "FBgn0004584", "FBgn0026869" ] }, "reaction_10474554": { "compartment": "compartment_7660", "id": "reaction_10474554", "reactome": "R-DME-5649856", "name": "Oxidative damage to the AP site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434060" ], "products": [ "species_10474552" ], "modifiers": [], "additional_components": [ "P27864", "FBgn0004584", "P27864", "FBgn0004584" ] }, "reaction_10434078": { "compartment": "compartment_7660", "id": "reaction_10434078", "reactome": "R-DME-110368", "name": "POLD,POLE-mediated DNA strand displacement synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10434075" ], "products": [ "species_10434071", "species_113541" ], "modifiers": [ [ "species_10434075", "catalyst" ] ], "additional_components": [ "P27864", "FBgn0004584", "Q7K7A9", "FBgn0025832", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P27864", "FBgn0004584", "Q7K7A9", "FBgn0025832", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P27864", "FBgn0004584", "Q7K7A9", "FBgn0025832", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10434086": { "compartment": "compartment_7660", "id": "reaction_10434086", "reactome": "R-DME-110371", "name": "LIG1 binds APEX1 and PCNA at SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434082", "species_10427699" ], "products": [ "species_10434084" ], "modifiers": [], "additional_components": [ "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "FBgn0262619", "Q9W1H4", "FBgn0262619", "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10474561": { "compartment": "compartment_7660", "id": "reaction_10474561", "reactome": "R-DME-5651805", "name": "LIG1 bound to APEX1 and PCNA ligates SSB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434084" ], "products": [ "species_10474558" ], "modifiers": [ [ "species_10434084", "catalyst" ] ], "additional_components": [ "Q9W1H4", "FBgn0262619", "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P27864", "FBgn0004584", "Q9W1H4", "FBgn0262619", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q9W1H4", "FBgn0262619", "P27864", "FBgn0004584", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10432365": { "compartment": "compartment_7660", "id": "reaction_10432365", "reactome": "R-DME-75172", "name": "Formation of RAD50:MRE11 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432356", "species_10432361" ], "products": [ "species_10432363" ], "modifiers": [], "additional_components": [ "FBgn0034728", "FBgn0020270", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728" ] }, "reaction_10468909": { "compartment": "compartment_7660", "id": "reaction_10468909", "reactome": "R-DME-3785768", "name": "MRN complex binds DNA double strand breaks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75165", "species_10432372" ], "products": [ "species_10468907" ], "modifiers": [], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476443": { "compartment": "compartment_70101", "id": "reaction_10476443", "reactome": "R-DME-5684008", "name": "NBN binds KPNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476433", "species_10476435" ], "products": [ "species_10476437" ], "modifiers": [], "additional_components": [ "FBgn0267727", "FBgn0261530", "Q9VT40", "FBgn0261530", "P52295", "FBgn0267727" ] }, "reaction_10476441": { "compartment": "compartment_7660", "id": "reaction_10476441", "reactome": "R-DME-5684006", "name": "KPNA2 translocates NBN to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476437" ], "products": [ "species_10432370", "species_10476439" ], "modifiers": [], "additional_components": [ "Q9VT40", "FBgn0261530", "P52295", "FBgn0267727", "FBgn0261530", "FBgn0267727" ] }, "reaction_10432374": { "compartment": "compartment_7660", "id": "reaction_10432374", "reactome": "R-DME-75174", "name": "Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432370", "species_10432363" ], "products": [ "species_10432372" ], "modifiers": [], "additional_components": [ "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476320": { "compartment": "compartment_7660", "id": "reaction_10476320", "reactome": "R-DME-5682044", "name": "KAT5 acetylates ATM at DNA DSBs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10476315" ], "products": [ "species_2485002", "species_10476317" ], "modifiers": [ [ "species_10476315", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080" ] }, "reaction_10476396": { "compartment": "compartment_7660", "id": "reaction_10476396", "reactome": "R-DME-5683792", "name": "p-T68-CHEK2 autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10476391" ], "products": [ "species_113582", "species_10427797" ], "modifiers": [ [ "species_10476391", "catalyst" ] ], "additional_components": [ "O61267", "FBgn0019686", "FBgn0019686", "O61267", "FBgn0019686" ] }, "reaction_10476393": { "compartment": "compartment_7660", "id": "reaction_10476393", "reactome": "R-DME-5683774", "name": "p-T68-CHEK2 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476389" ], "products": [ "species_10476391" ], "modifiers": [], "additional_components": [ "FBgn0019686", "O61267", "FBgn0019686" ] }, "reaction_10478112": { "compartment": "compartment_7660", "id": "reaction_10478112", "reactome": "R-DME-5693598", "name": "ATM phosphorylates NBN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10478100" ], "products": [ "species_113582", "species_10476458" ], "modifiers": [ [ "species_10478100", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080" ] }, "reaction_10476764": { "compartment": "compartment_7660", "id": "reaction_10476764", "reactome": "R-DME-5687664", "name": "FEN1 cleaves displaced ssDNA flaps during MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10476754" ], "products": [ "species_68454", "species_10476761", "species_10427691" ], "modifiers": [ [ "species_10476754", "catalyst" ] ], "additional_components": [ "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "FBgn0025832", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476728": { "compartment": "compartment_7660", "id": "reaction_10476728", "reactome": "R-DME-5687464", "name": "MRN and RBBP8 resect DNA DSBs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10476721" ], "products": [ "species_30555", "species_10476725" ], "modifiers": [ [ "species_10476721", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476743": { "compartment": "compartment_7660", "id": "reaction_10476743", "reactome": "R-DME-5687484", "name": "PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476725", "species_10474568", "species_10427691", "species_10476735" ], "products": [ "species_10476741" ], "modifiers": [], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "FBgn0025832", "O18475", "FBgn0002905", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "P35875", "FBgn0010247", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476757": { "compartment": "compartment_7660", "id": "reaction_10476757", "reactome": "R-DME-5687653", "name": "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10476749" ], "products": [ "species_427497", "species_10476754", "species_10474566", "species_10476735" ], "modifiers": [ [ "species_10476749", "catalyst" ] ], "additional_components": [ "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "O18475", "FBgn0002905", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247" ] }, "reaction_10476752": { "compartment": "compartment_7660", "id": "reaction_10476752", "reactome": "R-DME-5687640", "name": "POLQ extends annealed 3'-ssDNA overhangs in MMEJ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10476741" ], "products": [ "species_113541", "species_10476749" ], "modifiers": [ [ "species_10476741", "catalyst" ] ], "additional_components": [ "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "P35875", "FBgn0010247", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "P35875", "FBgn0010247", "O18475", "FBgn0002905", "Q7K7A9", "FBgn0025832", "P35875", "FBgn0010247", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10476768": { "compartment": "compartment_7660", "id": "reaction_10476768", "reactome": "R-DME-5687673", "name": "MRN recruits LIG3:XRCC1 to MMEJ sites", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434098", "species_10476761" ], "products": [ "species_10476766" ], "modifiers": [], "additional_components": [ "Q9Y095", "FBgn0026751", "Q9VG84", "FBgn0286075", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9Y095", "FBgn0026751", "Q9VG84", "FBgn0286075" ] }, "reaction_10476783": { "compartment": "compartment_7660", "id": "reaction_10476783", "reactome": "R-DME-5687758", "name": "PPP4C:PPP4R2 dephosphorylates RPA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10476563" ], "products": [ "species_113550", "species_10427667" ], "modifiers": [ [ "species_10476780", "catalyst" ] ], "additional_components": [ "Q24492", "FBgn0010173", "Q9VYW3", "FBgn0266421", "Q9VIH1", "FBgn0032906", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W2U4", "FBgn0030208", "O76932", "FBgn0023177" ] }, "reaction_10476631": { "compartment": "compartment_7660", "id": "reaction_10476631", "reactome": "R-DME-5686430", "name": "MUS81 binds EME1, EME2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476616", "species_10476623" ], "products": [ "species_10476629" ], "modifiers": [], "additional_components": [ "FBgn0033549", "FBgn0040347", "Q9V3T1", "FBgn0040347", "A1Z8C0", "FBgn0033549" ] }, "reaction_10476647": { "compartment": "compartment_7660", "id": "reaction_10476647", "reactome": "R-DME-5686475", "name": "SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476643", "species_10476629" ], "products": [ "species_10476645" ], "modifiers": [], "additional_components": [ "Q9VN41", "FBgn0037263", "Q9VS48", "FBgn0002909", "Q9V3T1", "FBgn0040347", "A1Z8C0", "FBgn0033549", "Q9V3T1", "FBgn0040347", "A1Z8C0", "FBgn0033549", "Q9VN41", "FBgn0037263", "Q9VS48", "FBgn0002909" ] }, "reaction_10476597": { "compartment": "compartment_7660", "id": "reaction_10476597", "reactome": "R-DME-5685230", "name": "CHEK1 phosphorylates RAD51", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476592", "species_29358" ], "products": [ "species_113582", "species_10476595" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "FBgn0003479", "FBgn0003479", "FBgn0261278" ] }, "reaction_10479290": { "compartment": "compartment_7660", "id": "reaction_10479290", "reactome": "R-DME-6781824", "name": "Active RNA Pol II complex transcribes lesion-containing DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479283", "species_6781829" ], "products": [ "species_10479287", "species_113541" ], "modifiers": [ [ "species_10479283", "catalyst" ] ], "additional_components": [ "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10479322": { "compartment": "compartment_7660", "id": "reaction_10479322", "reactome": "R-DME-6781867", "name": "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479302", "species_10427430" ], "products": [ "species_10479319" ], "modifiers": [ [ "species_10479302", "catalyst" ] ], "additional_components": [ "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962" ] }, "reaction_10479304": { "compartment": "compartment_7660", "id": "reaction_10479304", "reactome": "R-DME-6781833", "name": "ERCC8 (CSA) binds stalled RNA Pol II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479300", "species_10479294" ], "products": [ "species_10479302", "species_10477930" ], "modifiers": [], "additional_components": [ "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057" ] }, "reaction_10479285": { "compartment": "compartment_7660", "id": "reaction_10479285", "reactome": "R-DME-6781818", "name": "RNA Pol II initiates transcription from damaged DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431174", "species_10429254", "species_5688114" ], "products": [ "species_10479283" ], "modifiers": [], "additional_components": [ "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10479365": { "compartment": "compartment_7660", "id": "reaction_10479365", "reactome": "R-DME-6782069", "name": "UVSSA:USP7 deubiquitinates ERCC6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479356" ], "products": [ "species_10479362", "species_10427430" ], "modifiers": [ [ "species_10479356", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366" ] }, "reaction_10479390": { "compartment": "compartment_7660", "id": "reaction_10479390", "reactome": "R-DME-6782141", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433815", "species_10479386" ], "products": [ "species_10479388" ], "modifiers": [], "additional_components": [ "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10479406": { "compartment": "compartment_7660", "id": "reaction_10479406", "reactome": "R-DME-6782211", "name": "DNA polymerases delta, epsilon or kappa bind the TC-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479388" ], "products": [ "species_10479392" ], "modifiers": [ [ "species_10479388", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P20232", "FBgn0010422", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P28518", "FBgn0004832", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10479376": { "compartment": "compartment_7660", "id": "reaction_10479376", "reactome": "R-DME-6782131", "name": "ERCC2-facilitated RNA Pol II backtracking in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10479362" ], "products": [ "species_113550", "species_113582", "species_10479373" ], "modifiers": [ [ "species_10479362", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "P20232", "FBgn0010422", "M9MS40", "FBgn0261617", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "P28518", "FBgn0004832", "Q9VYQ8", "FBgn0030366", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962" ] }, "reaction_10479402": { "compartment": "compartment_7660", "id": "reaction_10479402", "reactome": "R-DME-6782208", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10479397" ], "products": [ "species_10479399", "species_113541" ], "modifiers": [ [ "species_10479397", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366" ] }, "reaction_10479413": { "compartment": "compartment_7660", "id": "reaction_10479413", "reactome": "R-DME-6782227", "name": "Ligation of newly synthesized repair patch to incised DNA in TC-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479399" ], "products": [ "species_10479408", "species_10477658" ], "modifiers": [ [ "species_10479410", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "M9MS40", "FBgn0261617", "P20232", "FBgn0010422", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "Q9VNZ3", "FBgn0037121", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "P04052", "FBgn0003277", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "A1Z9G2", "FBgn0033859", "Q7KLW9", "FBgn0261119", "Q9VHV6", "FBgn0037550", "Q9VT21", "FBgn0036020", "Q9V3G3", "FBgn0028382", "Q9VBY5", "FBgn0039271", "Q7KSN8", "FBgn0051368", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9XYZ5", "FBgn0260962", "Q9VYQ8", "FBgn0030366", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W1H4", "FBgn0262619", "Q9Y095", "FBgn0026751", "Q9VG84", "FBgn0286075" ] }, "reaction_10477876": { "compartment": "compartment_7660", "id": "reaction_10477876", "reactome": "R-DME-5691001", "name": "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477873", "species_30555" ], "products": [ "species_113541", "species_10477869" ], "modifiers": [ [ "species_10477873", "catalyst" ] ], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10479228": { "compartment": "compartment_7660", "id": "reaction_10479228", "reactome": "R-DME-5696664", "name": "PARP1 or PARP2 binds DDB2 at GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479224", "species_427523" ], "products": [ "species_427497", "species_10477240" ], "modifiers": [], "additional_components": [ "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698" ] }, "reaction_10477880": { "compartment": "compartment_7660", "id": "reaction_10477880", "reactome": "R-DME-5691004", "name": "XPC binds RAD23 and CETN2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477878", "species_5688114", "species_10477932" ], "products": [ "species_10477930", "species_10477934" ], "modifiers": [ [ "species_10477169", "catalyst" ] ], "additional_components": [ "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "Q24595", "FBgn0004698", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "Q24595", "FBgn0004698", "Q7K012", "FBgn0025716", "Q9Y0Z1", "FBgn0027503", "Q8ST83", "FBgn0002521", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "Q9W3D4", "FBgn0040929", "Q9VH07", "FBgn0040078", "A1Z6E8", "FBgn0033019", "A1Z8D5", "FBgn0033566", "Q9VX09", "FBgn0030877", "Q9VFH4", "FBgn0086686", "Q9VEC3", "FBgn0038576", "Q4V604", "FBgn0052202", "Q9VDY1", "FBgn0086613", "Q9VZJ3", "FBgn0263832" ] }, "reaction_10477871": { "compartment": "compartment_7660", "id": "reaction_10477871", "reactome": "R-DME-5691000", "name": "TFIIH binds GG-NER site to form a verification complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431174", "species_10477240" ], "products": [ "species_10477242" ], "modifiers": [], "additional_components": [ "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10477865": { "compartment": "compartment_7660", "id": "reaction_10477865", "reactome": "R-DME-5690996", "name": "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10477858" ], "products": [ "species_113550", "species_113582", "species_10477862" ], "modifiers": [ [ "species_10477858", "catalyst" ] ], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P28518", "FBgn0004832", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P28518", "FBgn0004832" ] }, "reaction_10433817": { "compartment": "compartment_7660", "id": "reaction_10433817", "reactome": "R-DME-109955", "name": "Formation of ERCC1:XPF heterodimeric complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433808", "species_10433813" ], "products": [ "species_10433815" ], "modifiers": [], "additional_components": [ "FBgn0028434", "FBgn0002707", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10480324": { "compartment": "compartment_7660", "id": "reaction_10480324", "reactome": "R-DME-6790454", "name": "SUMOylation of XPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480310", "species_10477862" ], "products": [ "species_10467222", "species_10480319" ], "modifiers": [ [ "species_10480321", "catalyst" ] ], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "FBgn0010602", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q24595", "FBgn0004698", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O97102", "FBgn0264922", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832" ] }, "reaction_10477248": { "compartment": "compartment_7660", "id": "reaction_10477248", "reactome": "R-DME-5689861", "name": "Recruitment of XPA and release of CAK ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477221", "species_10477242" ], "products": [ "species_10431137", "species_10477246" ], "modifiers": [], "additional_components": [ "FBgn0004832", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "P35875", "FBgn0010247", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3W9", "FBgn0026777", "Q9VCD5", "FBgn0039147", "Q8T415", "FBgn0051802", "M9PGG8", "FBgn0040010", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q24595", "FBgn0004698", "P28518", "FBgn0004832" ] }, "reaction_10477856": { "compartment": "compartment_7660", "id": "reaction_10477856", "reactome": "R-DME-5690991", "name": "Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433815", "species_10477849" ], "products": [ "species_10477851" ], "modifiers": [], "additional_components": [ "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10477854": { "compartment": "compartment_7660", "id": "reaction_10477854", "reactome": "R-DME-5690990", "name": "5'- incision of DNA by ERCC1:ERCC4 in GG-NER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477851" ], "products": [ "species_10477652" ], "modifiers": [ [ "species_10477851", "catalyst" ] ], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434" ] }, "reaction_10477662": { "compartment": "compartment_7660", "id": "reaction_10477662", "reactome": "R-DME-5690213", "name": "DNA polymerases delta, epsilon or kappa bind the GG-NER site", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434065", "species_10477652", "species_10477654", "species_10427622" ], "products": [ "species_10477660" ], "modifiers": [], "additional_components": [ "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P35875", "FBgn0010247", "P28518", "FBgn0004832", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q960E8", "FBgn0033929", "Q02870", "FBgn0001179", "Q9VUR1", "FBgn0261109", "Q7KVP9", "FBgn0261850", "Q9VNP8", "FBgn0037202", "B7Z018", "FBgn0265968", "Q9VPX4", "FBgn0031309", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24087", "FBgn0002707", "Q7KMG7", "FBgn0028434", "P35875", "FBgn0010247", "P28518", "FBgn0004832" ] }, "reaction_10475262": { "compartment": "compartment_7660", "id": "reaction_10475262", "reactome": "R-DME-5655466", "name": "USP1:WDR48 deubiquitinates monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475257" ], "products": [ "species_10427430", "species_10475255", "species_10475259" ], "modifiers": [ [ "species_10475257", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476" ] }, "reaction_10474603": { "compartment": "compartment_7660", "id": "reaction_10474603", "reactome": "R-DME-5652005", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474580", "species_10474599" ], "products": [ "species_10474601" ], "modifiers": [], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10475271": { "compartment": "compartment_7660", "id": "reaction_10475271", "reactome": "R-DME-5655483", "name": "USP1 autocleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475255" ], "products": [ "species_10475266", "species_10475268", "species_10475253" ], "modifiers": [ [ "species_10475255", "catalyst" ] ], "additional_components": [ "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "FBgn0028476", "FBgn0028476", "FBgn0033607", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476" ] }, "reaction_10474608": { "compartment": "compartment_7660", "id": "reaction_10474608", "reactome": "R-DME-5652009", "name": "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10474601" ], "products": [ "species_10434065", "species_10474599", "species_10474605" ], "modifiers": [ [ "species_10474601", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q24371", "FBgn0013548", "Q9XYZ5", "FBgn0260962", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10475264": { "compartment": "compartment_7660", "id": "reaction_10475264", "reactome": "R-DME-5655481", "name": "USP1:WDR48 binds monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475255", "species_10474605" ], "products": [ "species_10475257" ], "modifiers": [], "additional_components": [ "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q1LZ08", "FBgn0033607", "Q8I077", "FBgn0028476" ] }, "reaction_10475290": { "compartment": "compartment_7660", "id": "reaction_10475290", "reactome": "R-DME-5655892", "name": "POLK incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475281", "species_30555" ], "products": [ "species_10475287", "species_113541" ], "modifiers": [ [ "species_10475281", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150" ] }, "reaction_10475299": { "compartment": "compartment_7660", "id": "reaction_10475299", "reactome": "R-DME-5655965", "name": "POLK and POLZ cooperate in elongation of mispaired primer termini", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10475287" ], "products": [ "species_10475296", "species_10433955", "species_10433993", "species_113541" ], "modifiers": [ [ "species_10475287", "catalyst" ] ], "additional_components": [ "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "species_266099", "species_29926", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "species_266099", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150" ] }, "reaction_10433981": { "compartment": "compartment_7660", "id": "reaction_10433981", "reactome": "R-DME-110308", "name": "REV1 inserts dCMP opposite to AP sites in DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433970", "species_30185" ], "products": [ "species_10433978" ], "modifiers": [ [ "species_10433970", "catalyst" ] ], "additional_components": [ "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10434039": { "compartment": "compartment_7660", "id": "reaction_10434039", "reactome": "R-DME-110322", "name": "Formation of Pol zeta complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433986", "species_10433991" ], "products": [ "species_10433993" ], "modifiers": [], "additional_components": [ "FBgn0002891", "FBgn0037345", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891" ] }, "reaction_10433972": { "compartment": "compartment_7660", "id": "reaction_10433972", "reactome": "R-DME-110307", "name": "REV1 binds AP-dsDNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433968", "species_10433955" ], "products": [ "species_10433970" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0035150", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10474610": { "compartment": "compartment_7660", "id": "reaction_10474610", "reactome": "R-DME-5652151", "name": "REV1 recruits POLZ to (AP:Cyt)-DNA Template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433993", "species_10433978" ], "products": [ "species_10433995" ], "modifiers": [], "additional_components": [ "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891" ] }, "reaction_10434002": { "compartment": "compartment_7660", "id": "reaction_10434002", "reactome": "R-DME-110311", "name": "POLZ extends translesion synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10433995" ], "products": [ "species_10433993", "species_113541", "species_10433999" ], "modifiers": [ [ "species_10433995", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9W0P2", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891" ] }, "reaction_10475337": { "compartment": "compartment_7660", "id": "reaction_10475337", "reactome": "R-DME-5656158", "name": "POLZ elongates POLI-incorporated dNMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10475325" ], "products": [ "species_10433955", "species_10475334", "species_10433993", "species_113541" ], "modifiers": [ [ "species_10475325", "catalyst" ] ], "additional_components": [ "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "FBgn0035150", "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150" ] }, "reaction_10475319": { "compartment": "compartment_7660", "id": "reaction_10475319", "reactome": "R-DME-5656105", "name": "POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475315", "species_10433955", "species_10433993", "species_10475311" ], "products": [ "species_10475317" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "FBgn0035150", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9VHV1", "FBgn0037554", "species_29926", "Q9VHV1", "FBgn0037554", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10475328": { "compartment": "compartment_7660", "id": "reaction_10475328", "reactome": "R-DME-5656148", "name": "POLI incorporates dNMP opposite to damaged DNA base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10475317" ], "products": [ "species_113541", "species_10475325" ], "modifiers": [ [ "species_10475317", "catalyst" ] ], "additional_components": [ "Q9VHV1", "FBgn0037554", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VHV1", "FBgn0037554", "species_29926", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "Q9VHV1", "FBgn0037554", "species_29926", "Q9VNE1", "FBgn0037345", "Q9GSR1", "FBgn0002891", "Q9W0P2", "FBgn0035150", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10474686": { "compartment": "compartment_7660", "id": "reaction_10474686", "reactome": "R-DME-5653838", "name": "POLD,POLE binds deISGylated PCNA after TLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434065", "species_10474682" ], "products": [ "species_10474684" ], "modifiers": [], "additional_components": [ "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655" ] }, "reaction_10474680": { "compartment": "compartment_7660", "id": "reaction_10474680", "reactome": "R-DME-5653780", "name": "USP43 binds ISG:K164,ISG:K168-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474672", "species_10474676" ], "products": [ "species_10474678" ], "modifiers": [], "additional_components": [ "FBgn0050421", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "Q9W117", "FBgn0050421" ] }, "reaction_10434030": { "compartment": "compartment_7660", "id": "reaction_10434030", "reactome": "R-DME-110317", "name": "Insertion of correct bases opposite the lesion by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29604", "species_10434013" ], "products": [ "species_113541", "species_10434027" ], "modifiers": [ [ "species_10434013", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141" ] }, "reaction_10475228": { "compartment": "compartment_7660", "id": "reaction_10475228", "reactome": "R-DME-5654989", "name": "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10475219" ], "products": [ "species_113582", "species_10434007", "species_10475225" ], "modifiers": [ [ "species_10475219", "catalyst" ] ], "additional_components": [ "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784", "FBgn0037141", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784" ] }, "reaction_10475243": { "compartment": "compartment_7660", "id": "reaction_10475243", "reactome": "R-DME-5655170", "name": "RCHY1 monoubiquitinates POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10475230" ], "products": [ "species_10434018", "species_10475240" ], "modifiers": [ [ "species_10475230", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VNX1", "FBgn0037141", "Q9VMD4", "FBgn0031816", "FBgn0031816", "Q9VNX1", "FBgn0037141", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VNX1", "FBgn0037141", "Q9VMD4", "FBgn0031816" ] }, "reaction_10475223": { "compartment": "compartment_7660", "id": "reaction_10475223", "reactome": "R-DME-5654986", "name": "SPRTN binds monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434034", "species_10475199" ], "products": [ "species_10475201" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "FBgn0267977", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141" ] }, "reaction_10434037": { "compartment": "compartment_7660", "id": "reaction_10434037", "reactome": "R-DME-110319", "name": "Elongation by POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30555", "species_10434027" ], "products": [ "species_10434034", "species_113541" ], "modifiers": [ [ "species_10434027", "catalyst" ] ], "additional_components": [ "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141" ] }, "reaction_10475221": { "compartment": "compartment_7660", "id": "reaction_10475221", "reactome": "R-DME-5654985", "name": "SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475217", "species_10475201" ], "products": [ "species_10475219" ], "modifiers": [], "additional_components": [ "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VXU6", "FBgn0267977", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "Q9VTF9", "FBgn0036136", "Q9VBP9", "FBgn0039348", "Q7KN62", "FBgn0286784" ] }, "reaction_10434020": { "compartment": "compartment_7660", "id": "reaction_10434020", "reactome": "R-DME-110316", "name": "POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434007", "species_10434011" ], "products": [ "species_10434013" ], "modifiers": [ [ "species_10434018", "inhibitor" ] ], "additional_components": [ "FBgn0037141", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P17917", "FBgn0005655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "P35600", "FBgn0004913", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VNX1", "FBgn0037141", "FBgn0031816" ] }, "reaction_10475232": { "compartment": "compartment_7660", "id": "reaction_10475232", "reactome": "R-DME-5655142", "name": "RCHY1 binds POLH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434018", "species_10434007" ], "products": [ "species_10475230" ], "modifiers": [], "additional_components": [ "FBgn0031816", "FBgn0037141", "Q9VNX1", "FBgn0037141", "Q9VMD4", "FBgn0031816" ] }, "reaction_10479709": { "compartment": "compartment_7660", "id": "reaction_10479709", "reactome": "R-DME-6785594", "name": "FANCD2 binds FANCI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479700", "species_10479705" ], "products": [ "species_10479707" ], "modifiers": [], "additional_components": [ "FBgn0038827", "FBgn0033354", "A1Z7L1", "FBgn0033354", "Q8MYL1", "FBgn0038827" ] }, "reaction_10449934": { "compartment": "compartment_876", "id": "reaction_10449934", "reactome": "R-DME-444008", "name": "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972", "species_114523", "species_74113" ], "products": [ "species_209914", "species_83910", "species_352022" ], "modifiers": [ [ "species_10449931", "catalyst" ] ], "additional_components": [ "FBgn0010414" ] }, "reaction_10445846": { "compartment": "compartment_5460", "id": "reaction_10445846", "reactome": "R-DME-380608", "name": "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_380598" ], "products": [ "species_113529", "species_380593", "species_29362" ], "modifiers": [ [ "species_10429091", "catalyst" ] ], "additional_components": [ "Q9VLC5", "FBgn0012036" ] }, "reaction_10444860": { "compartment": "compartment_984", "id": "reaction_10444860", "reactome": "R-DME-374919", "name": "Noradrenaline clearance from the synaptic cleft", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374935" ], "products": [ "species_209789" ], "modifiers": [ [ "species_10444836", "catalyst" ] ], "additional_components": [ "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q7K3M6", "FBgn0034479", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10497879": { "compartment": "compartment_876", "id": "reaction_10497879", "reactome": "R-DME-9634834", "name": "ACHEIs bind ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444352", "species_9634838" ], "products": [ "species_10444355" ], "modifiers": [], "additional_components": [ "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943", "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943" ] }, "reaction_10444357": { "compartment": "compartment_984", "id": "reaction_10444357", "reactome": "R-DME-372519", "name": "AcCho is hydrolyzed to Cho and acetate by ACHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_372533" ], "products": [ "species_1524044", "species_264638" ], "modifiers": [ [ "species_10444352", "catalyst" ], [ "species_10444355", "inhibitor" ] ], "additional_components": [ "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943", "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943" ] }, "reaction_10486033": { "compartment": "compartment_7660", "id": "reaction_10486033", "reactome": "R-DME-6804468", "name": "PIAS1 SUMOylates SP3 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467290", "species_10467901" ], "products": [ "species_10486031", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q9VPQ5", "FBgn0043364", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "M9PJG1", "FBgn0020378", "Q24266", "FBgn0000233", "Q2MGN0", "FBgn0034946", "Q9VPQ5", "FBgn0043364", "FBgn0010602", "FBgn0003612" ] }, "reaction_10470035": { "compartment": "compartment_7660", "id": "reaction_10470035", "reactome": "R-DME-4641350", "name": "PIAS4 SUMOylates TOP2A with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470028" ], "products": [ "species_10470033", "species_10467222" ], "modifiers": [ [ "species_10469560", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0284220", "FBgn0284220", "FBgn0010602", "FBgn0003612" ] }, "reaction_10470128": { "compartment": "compartment_70101", "id": "reaction_10470128", "reactome": "R-DME-4655355", "name": "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470071" ], "products": [ "species_10470093", "species_10470095" ], "modifiers": [ [ "species_10469818", "catalyst" ], [ "species_10470125", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "Q7JRJ9", "FBgn0260991", "Q9VLD6", "FBgn0032105", "Q9VLD7", "FBgn0032104", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VLD7", "FBgn0032104", "Q9VLD6", "FBgn0032105", "Q7JRJ9", "FBgn0260991", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "FBgn0010602", "FBgn0003612", "A1YK02", "FBgn0034310", "A1Z8P9", "FBgn0013756", "Q9VE85", "FBgn0038609", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VCH5", "FBgn0039120", "Q9VBU8", "FBgn0039301", "Q9V466", "FBgn0027868", "Q9VCW3", "FBgn0039004", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "A1Z6H7", "FBgn0266580", "Q8IQV9", "FBgn0031078", "Q7K0D8", "FBgn0033264", "Q7KNM2", "FBgn0010602", "Q9VIW3", "FBgn0003346", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9VWS2", "FBgn0030943", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VFE7", "FBgn0038274", "Q7K2X8", "FBgn0033247", "Q9VXE6", "FBgn0061200", "Q9V463", "FBgn0021761" ] }, "reaction_10470191": { "compartment": "compartment_7660", "id": "reaction_10470191", "reactome": "R-DME-4755524", "name": "SUMOylation of NR1I2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10470184" ], "products": [ "species_10467222", "species_10470189" ], "modifiers": [], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "Q24143", "FBgn0015240", "CHEBI:28077", "FBgn0010602", "Q24143", "FBgn0015240", "CHEBI:28077" ] }, "reaction_10470143": { "compartment": "compartment_7660", "id": "reaction_10470143", "reactome": "R-DME-4719413", "name": "PIAS2,3,4 SUMOylate RORA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445281", "species_10467290" ], "products": [ "species_10467222", "species_10470138" ], "modifiers": [ [ "species_10470140", "catalyst" ] ], "additional_components": [ "P45447", "FBgn0004865", "P31396", "FBgn0000448", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "P45447", "FBgn0004865", "P31396", "FBgn0000448", "FBgn0003612" ] }, "reaction_10469820": { "compartment": "compartment_7660", "id": "reaction_10469820", "reactome": "R-DME-4546385", "name": "PIAS1,3 SUMOylates NR5A1 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445316", "species_10467290" ], "products": [ "species_10467222", "species_10469816" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0001078", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "FBgn0001078", "FBgn0003612" ] }, "reaction_10470156": { "compartment": "compartment_7660", "id": "reaction_10470156", "reactome": "R-DME-4719448", "name": "PIAS1 SUMOylates THRB with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10445311" ], "products": [ "species_10467222", "species_10470154" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "FBgn0000568", "FBgn0010602", "FBgn0000568", "FBgn0003612" ] }, "reaction_10470167": { "compartment": "compartment_7660", "id": "reaction_10470167", "reactome": "R-DME-4720432", "name": "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470158" ], "products": [ "species_10470164", "species_10467222" ], "modifiers": [ [ "species_10469978", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:1301", "CHEBI:34310", "CHEBI:1301", "P34021", "FBgn0000546", "FBgn0010602", "FBgn0041210" ] }, "reaction_10469718": { "compartment": "compartment_7660", "id": "reaction_10469718", "reactome": "R-DME-4341072", "name": "SUMOylation of RARA with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445299", "species_10467290" ], "products": [ "species_10469715", "species_10467222" ], "modifiers": [ [ "species_10467290", "catalyst" ] ], "additional_components": [ "FBgn0000568", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0000568", "FBgn0010602", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10470149": { "compartment": "compartment_7660", "id": "reaction_10470149", "reactome": "R-DME-4719423", "name": "PIAS2-2 SUMOylates THRA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10445309" ], "products": [ "species_10470147", "species_10467222" ], "modifiers": [ [ "species_10470140", "catalyst" ] ], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "FBgn0000568", "FBgn0000568", "FBgn0010602", "FBgn0003612" ] }, "reaction_10469826": { "compartment": "compartment_7660", "id": "reaction_10469826", "reactome": "R-DME-4546387", "name": "PIAS4 SUMOylates VDR with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445234", "species_10467290" ], "products": [ "species_10467222", "species_10469823" ], "modifiers": [ [ "species_10469560", "catalyst" ] ], "additional_components": [ "FBgn0015240", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0010602", "FBgn0015240", "FBgn0003612" ] }, "reaction_10470176": { "compartment": "compartment_7660", "id": "reaction_10470176", "reactome": "R-DME-4720446", "name": "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10470169" ], "products": [ "species_10467222", "species_10470174" ], "modifiers": [ [ "species_10469978", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:1301", "FBgn0010602", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:1301", "FBgn0041210" ] }, "reaction_10470211": { "compartment": "compartment_7660", "id": "reaction_10470211", "reactome": "R-DME-4755536", "name": "PIAS3 SUMOylates RELA with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470193", "species_10467298" ], "products": [ "species_10470209", "species_10467222" ], "modifiers": [ [ "species_10469818", "catalyst" ] ], "additional_components": [ "P98149", "Dif", "P15330", "dl", "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "P98149", "Dif", "P15330", "dl", "FBgn0010602", "FBgn0003612" ] }, "reaction_10469909": { "compartment": "compartment_7660", "id": "reaction_10469909", "reactome": "R-DME-4570499", "name": "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429333", "species_10467290" ], "products": [ "species_10469907", "species_10467222" ], "modifiers": [ [ "species_10467488", "catalyst" ] ], "additional_components": [ "FBgn0267791", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0267791", "FBgn0010602", "P26017", "FBgn0003042", "Q9VB08", "FBgn0003330", "Q9VHA0", "FBgn0003334", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "P39769", "FBgn0004861", "Q9VKL0", "FBgn0032330", "Q9W523", "FBgn0004860" ] }, "reaction_10469904": { "compartment": "compartment_7660", "id": "reaction_10469904", "reactome": "R-DME-4570489", "name": "SUMOylation of NOP58 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467290", "species_10469898" ], "products": [ "species_10467222", "species_10469902" ], "modifiers": [ [ "species_10467290", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0026196", "FBgn0010602", "FBgn0026196", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602" ] }, "reaction_10469992": { "compartment": "compartment_7660", "id": "reaction_10469992", "reactome": "R-DME-4615987", "name": "RANBP2 SUMOylates HDAC4 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10469978" ], "products": [ "species_10469989", "species_10467222" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0041210", "FBgn0041210", "FBgn0010602", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10469973": { "compartment": "compartment_7660", "id": "reaction_10469973", "reactome": "R-DME-4615839", "name": "PIAS1 SUMOylates SATB1 with SUMO2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467300", "species_10444232" ], "products": [ "species_10469971", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0020307", "FBgn0020307", "FBgn0010602", "FBgn0003612" ] }, "reaction_10486044": { "compartment": "compartment_7660", "id": "reaction_10486044", "reactome": "R-DME-6804485", "name": "PIAS1 SUMOylates L3MBTL2 with SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486038", "species_10467290" ], "products": [ "species_10486042", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "FBgn0032475", "O97102", "FBgn0264922", "Q7KNM2", "FBgn0010602", "FBgn0032475", "FBgn0010602", "FBgn0003612" ] }, "reaction_10469986": { "compartment": "compartment_7660", "id": "reaction_10469986", "reactome": "R-DME-4615900", "name": "PIAS1 SUMOylates SATB2 with SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467298", "species_10469980" ], "products": [ "species_10469984", "species_10467222" ], "modifiers": [ [ "species_10454160", "catalyst" ] ], "additional_components": [ "Q7KNM2", "FBgn0010602", "O97102", "FBgn0264922", "FBgn0020307", "FBgn0020307", "FBgn0010602", "FBgn0003612" ] }, "reaction_10467179": { "compartment": "compartment_7660", "id": "reaction_10467179", "reactome": "R-DME-2990842", "name": "SENP1,2,5 proteolytically process SUMO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467152" ], "products": [ "species_10467154" ], "modifiers": [ [ "species_10467176", "catalyst" ] ], "additional_components": [ "FBgn0264922", "FBgn0264922", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110" ] }, "reaction_10467217": { "compartment": "compartment_7660", "id": "reaction_10467217", "reactome": "R-DME-2993763", "name": "SENP1,2,5 proteolytically process SUMO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467213" ], "products": [ "species_10467215" ], "modifiers": [ [ "species_10467176", "catalyst" ] ], "additional_components": [ "FBgn0264922", "FBgn0264922", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110" ] }, "reaction_10493344": { "compartment": "compartment_7660", "id": "reaction_10493344", "reactome": "R-DME-8943817", "name": "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493338", "species_10493336" ], "products": [ "species_10493342" ], "modifiers": [], "additional_components": [ "Q8I7Z8", "FBgn0045852", "Q8I7Z8", "FBgn0045852" ] }, "reaction_10493329": { "compartment": "compartment_7660", "id": "reaction_10493329", "reactome": "R-DME-8943780", "name": "SALL4 recruits NuRD to PTEN gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493323", "species_10493319" ], "products": [ "species_10493327" ], "modifiers": [], "additional_components": [ "Q94517", "HDAC1", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q24572", "FBgn0263979", "Q9VKH3", "FBgn0000287", "P39770", "FBgn0261648", "Q9VKH3", "FBgn0000287", "P39770", "FBgn0261648", "Q94517", "HDAC1", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q24572", "FBgn0263979" ] }, "reaction_10493377": { "compartment": "compartment_13231", "id": "reaction_10493377", "reactome": "R-DME-8944457", "name": "MAF1 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493368" ], "products": [ "species_10493366" ], "modifiers": [ [ "species_10437040", "inhibitor" ] ], "additional_components": [ "FBgn0267861", "FBgn0267861", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10493375": { "compartment": "compartment_70101", "id": "reaction_10493375", "reactome": "R-DME-8944454", "name": "mTORC1 phosphorylates MAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10493368" ], "products": [ "species_10493373", "species_29370" ], "modifiers": [ [ "species_10437040", "catalyst" ] ], "additional_components": [ "FBgn0267861", "FBgn0267861", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10467806": { "compartment": "compartment_70101", "id": "reaction_10467806", "reactome": "R-DME-3228469", "name": "MAP3K5 phosphorylates MKK3 and MKK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10450922" ], "products": [ "species_10450883", "species_29370" ], "modifiers": [ [ "species_10467790", "catalyst" ] ], "additional_components": [ "FBgn0261524", "FBgn0261524", "FBgn0014006" ] }, "reaction_10467802": { "compartment": "compartment_70101", "id": "reaction_10467802", "reactome": "R-DME-3225851", "name": "ROS oxidize thioredoxin and activate MAP3K5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467792", "species_1250243" ], "products": [ "species_10430994", "species_10467790" ], "modifiers": [ [ "species_10467796", "catalyst" ] ], "additional_components": [ "Q9VDS9", "FBgn0014006", "Q9V429", "FBgn0040070", "FBgn0040070", "FBgn0014006" ] }, "reaction_10495401": { "compartment": "compartment_7660", "id": "reaction_10495401", "reactome": "R-DME-8979071", "name": "KDM6B binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495397", "species_111793" ], "products": [ "species_10495399" ], "modifiers": [], "additional_components": [ "FBgn0260749", "species_111793", "Q9VL07", "FBgn0260749" ] }, "reaction_10467889": { "compartment": "compartment_7660", "id": "reaction_10467889", "reactome": "R-DME-3240957", "name": "Formation of PRC2-EZH2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458993", "species_10467875", "species_10467880", "species_10467885" ], "products": [ "species_10467887" ], "modifiers": [], "additional_components": [ "FBgn0263979", "FBgn0032391", "FBgn0000629", "FBgn0020887", "Q9NJG9", "FBgn0020887", "P42124", "FBgn0000629", "Q9VKD5", "FBgn0032391", "Q24572", "FBgn0263979" ] }, "reaction_10473727": { "compartment": "compartment_13949", "id": "reaction_10473727", "reactome": "R-DME-5623524", "name": "The exocyst complex binds to RAB3IP in the ciliary targeting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473705", "species_10473723" ], "products": [ "species_10473725" ], "modifiers": [], "additional_components": [ "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "species_29438", "O18335", "FBgn0015790", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9V8K2", "FBgn0266671", "Q9VQQ9", "FBgn0266670", "Q9VVG4", "FBgn0266669", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VDE6", "FBgn0266674", "Q9XTM1", "FBgn0266673", "Q9VNH6", "FBgn0266672", "Q9V8K2", "FBgn0266671", "Q9VQQ9", "FBgn0266670", "Q9VVG4", "FBgn0266669", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VDE6", "FBgn0266674", "Q9XTM1", "FBgn0266673", "Q9VNH6", "FBgn0266672", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "species_29438", "O18335", "FBgn0015790", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145" ] }, "reaction_10473635": { "compartment": "compartment_70101", "id": "reaction_10473635", "reactome": "R-DME-5623508", "name": "GBF1 stimulates nucleotide exchange on ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10473633" ], "products": [ "species_29420", "species_10473517" ], "modifiers": [ [ "species_10444051", "catalyst" ] ], "additional_components": [ "P40945", "FBgn0013749", "species_29420", "P40945", "FBgn0013749", "species_29438", "FBgn0264560" ] }, "reaction_10473683": { "compartment": "compartment_20699", "id": "reaction_10473683", "reactome": "R-DME-5623513", "name": "ASAP1 stimulates GTPase activity of ARF4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10473678" ], "products": [ "species_10473680", "species_10473633", "species_29372" ], "modifiers": [ [ "species_10473678", "catalyst" ] ], "additional_components": [ "O18335", "FBgn0015790", "species_29438", "M9ND89", "FBgn0013718", "P40945", "FBgn0013749", "A1Z7A6", "FBgn0050372", "O18335", "FBgn0015790", "species_29438", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "P40945", "FBgn0013749", "species_29420", "O18335", "FBgn0015790", "species_29438", "M9ND89", "FBgn0013718", "P40945", "FBgn0013749", "A1Z7A6", "FBgn0050372" ] }, "reaction_10473745": { "compartment": "compartment_261122", "id": "reaction_10473745", "reactome": "R-DME-5623527", "name": "VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473725" ], "products": [ "species_10473743" ], "modifiers": [], "additional_components": [ "Q9V8K2", "FBgn0266671", "Q9VQQ9", "FBgn0266670", "Q9VVG4", "FBgn0266669", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VDE6", "FBgn0266674", "Q9XTM1", "FBgn0266673", "Q9VNH6", "FBgn0266672", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "species_29438", "O18335", "FBgn0015790", "A1Z7A6", "FBgn0050372", "M9ND89", "FBgn0013718", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145" ] }, "reaction_10433822": { "compartment": "compartment_70101", "id": "reaction_10433822", "reactome": "R-DME-110133", "name": "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500077" ], "products": [ "species_113592", "species_500071" ], "modifiers": [ [ "species_10431187", "catalyst" ] ], "additional_components": [ "species_29420", "CHEBI:28862", "species_5696194", "CHEBI:16192", "FBgn0036099" ] }, "reaction_10452894": { "compartment": "compartment_70101", "id": "reaction_10452894", "reactome": "R-DME-482621", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_482625" ], "products": [ "species_113592", "species_482627" ], "modifiers": [ [ "species_10452889", "catalyst" ] ], "additional_components": [ "species_29892", "species_29604", "species_30185", "species_29494", "species_30187", "species_110577", "species_500739", "species_29438", "species_205687", "CHEBI:28846", "CHEBI:16174", "species_29420", "CHEBI:28850", "CHEBI:28862", "CHEBI:18075", "species_110094", "P08879", "FBgn0000150" ] }, "reaction_10480029": { "compartment": "compartment_7660", "id": "reaction_10480029", "reactome": "R-DME-6788810", "name": "AK6 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_6788813" ], "products": [ "species_113582", "species_6788807" ], "modifiers": [ [ "species_10480026", "catalyst" ] ], "additional_components": [ "CHEBI:15918", "species_1524067", "species_76577", "species_109386", "species_110094", "CHEBI:16174", "CHEBI:28846", "species_29370", "FBgn0033754" ] }, "reaction_10432346": { "compartment": "compartment_70101", "id": "reaction_10432346", "reactome": "R-DME-75126", "name": "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_499999" ], "products": [ "species_499997", "species_113592" ], "modifiers": [ [ "species_10430985", "catalyst" ] ], "additional_components": [ "CHEBI:28850", "CHEBI:18075", "species_109382", "species_109366", "A1ZB29", "FBgn0034299" ] }, "reaction_10432344": { "compartment": "compartment_70101", "id": "reaction_10432344", "reactome": "R-DME-75125", "name": "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_500006" ], "products": [ "species_500009", "species_113592" ], "modifiers": [ [ "species_10430860", "catalyst" ] ], "additional_components": [ "species_205687", "CHEBI:28846", "species_110094", "species_1524067", "CHEBI:15918", "species_418075", "Q9VBI2", "FBgn0028833" ] }, "reaction_10480021": { "compartment": "compartment_5460", "id": "reaction_10480021", "reactome": "R-DME-6788798", "name": "AK4 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6788802" ], "products": [ "species_113581", "species_6788801" ], "modifiers": [ [ "species_10480018", "catalyst" ] ], "additional_components": [ "species_1524067", "species_109386", "species_76577", "CHEBI:15918", "species_29370", "CHEBI:16174", "CHEBI:28846", "species_110094", "FBgn0042094" ] }, "reaction_10486254": { "compartment": "compartment_70101", "id": "reaction_10486254", "reactome": "R-DME-6806877", "name": "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_6806885" ], "products": [ "species_29370", "species_6806881" ], "modifiers": [ [ "species_10486251", "catalyst" ] ], "additional_components": [ "P08879", "FBgn0000150" ] }, "reaction_10431502": { "compartment": "compartment_70101", "id": "reaction_10431502", "reactome": "R-DME-74220", "name": "(d)AMP + ATP <=> (d)ADP + ADP (AK1)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_500088", "species_113592" ], "products": [ "species_29370", "species_500087" ], "modifiers": [ [ "species_10431499", "catalyst" ] ], "additional_components": [ "species_76577", "species_109386", "species_29370", "CHEBI:16174", "Q8IQG9", "FBgn0022709" ] }, "reaction_10453058": { "compartment": "compartment_70101", "id": "reaction_10453058", "reactome": "R-DME-504054", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10453055", "catalyst" ] ], "additional_components": [ "Q9VUL1", "FBgn0266452" ] }, "reaction_10433850": { "compartment": "compartment_70101", "id": "reaction_10433850", "reactome": "R-DME-110145", "name": "AMP + ATP <=> ADP + ADP [AK2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76577" ], "products": [ "species_29370" ], "modifiers": [ [ "species_10433845", "catalyst" ] ], "additional_components": [ "FBgn0283494" ] }, "reaction_10434170": { "compartment": "compartment_70101", "id": "reaction_10434170", "reactome": "R-DME-111804", "name": "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_8866401" ], "products": [ "species_10430994", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10434167", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "species_1222611", "P48592", "FBgn0011704", "P48591", "FBgn0011703" ] }, "reaction_10431033": { "compartment": "compartment_7660", "id": "reaction_10431033", "reactome": "R-DME-73666", "name": "dUTP + H2O => dUMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_500739" ], "products": [ "species_113541", "species_500742" ], "modifiers": [ [ "species_10431030", "catalyst" ] ], "additional_components": [ "Q9V3I1", "FBgn0250837" ] }, "reaction_10430962": { "compartment": "compartment_70101", "id": "reaction_10430962", "reactome": "R-DME-73605", "name": "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111355", "species_109382" ], "products": [ "species_109366", "species_73604" ], "modifiers": [ [ "species_10430959", "catalyst" ] ], "additional_components": [ "O76511", "FBgn0024920", "species_29926" ] }, "reaction_10434161": { "compartment": "compartment_70101", "id": "reaction_10434161", "reactome": "R-DME-111751", "name": "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_8866401" ], "products": [ "species_10430994", "species_29356", "species_8866399" ], "modifiers": [ [ "species_10434158", "catalyst" ], [ "species_113592", "catalyst" ], [ "species_110644", "inhibitor" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "P48592", "FBgn0011704", "species_1222611", "P48591", "FBgn0011703" ] }, "reaction_10431023": { "compartment": "compartment_70101", "id": "reaction_10431023", "reactome": "R-DME-73647", "name": "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_29494", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_110614" ], "modifiers": [ [ "species_10431020", "catalyst" ] ], "additional_components": [ "Q9VUL1", "FBgn0266452" ] }, "reaction_10433838": { "compartment": "compartment_70101", "id": "reaction_10433838", "reactome": "R-DME-110138", "name": "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788778", "species_113592" ], "products": [ "species_29370", "species_6788782" ], "modifiers": [ [ "species_10433833", "catalyst" ] ], "additional_components": [ "species_76577", "species_1524067", "CHEBI:15918", "species_109386", "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "Q8IQG9", "FBgn0022709", "M9PCF9", "FBgn0032083" ] }, "reaction_10433836": { "compartment": "compartment_70101", "id": "reaction_10433836", "reactome": "R-DME-110137", "name": "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370", "species_6788782" ], "products": [ "species_6788778", "species_113592" ], "modifiers": [ [ "species_10433833", "catalyst" ] ], "additional_components": [ "species_29370", "CHEBI:28846", "CHEBI:16174", "species_110094", "species_76577", "species_1524067", "CHEBI:15918", "species_109386", "Q8IQG9", "FBgn0022709", "M9PCF9", "FBgn0032083" ] }, "reaction_10453032": { "compartment": "compartment_5460", "id": "reaction_10453032", "reactome": "R-DME-482812", "name": "(d)NTP + ADP <=> (d)NDP + ATP (NME4)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113581", "species_482807" ], "products": [ "species_113593", "species_482803" ], "modifiers": [ [ "species_10453027", "catalyst" ] ], "additional_components": [ "species_110577", "species_29438", "species_500739", "species_29892", "species_29494", "species_29604", "species_30185", "species_30187", "CHEBI:18075", "species_29420", "CHEBI:28850", "CHEBI:28862", "species_205687", "CHEBI:16174", "CHEBI:28846", "species_110094", "P08879", "FBgn0000150" ] }, "reaction_10480797": { "compartment": "compartment_7660", "id": "reaction_10480797", "reactome": "R-DME-6791222", "name": "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480711" ], "products": [ "species_10480770" ], "modifiers": [ [ "species_10480794", "catalyst" ], [ "species_10480430", "catalyst" ], [ "species_10480782", "catalyst" ], [ "species_10480418", "catalyst" ] ], "additional_components": [ "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VGZ2", "FBgn0037815", "Q9VK19", "FBgn0032487", "Q8IPX7", "FBgn0260648", "Q9W1M9", "FBgn0034879", "Q9VKJ4", "FBgn0032346", "Q8T4A9", "FBgn0030789", "Q29QQ9", "FBgn0034065", "Q9VW53", "FBgn0036916", "Q9VFF3", "FBgn0038269", "Q9VXL4", "FBgn0030711", "Q95PE4", "FBgn0032921", "Q9Y134", "FBgn0001986", "FBgn0038269", "FBgn0037815", "FBgn0001986" ] }, "reaction_10480745": { "compartment": "compartment_7660", "id": "reaction_10480745", "reactome": "R-DME-6791221", "name": "30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480707" ], "products": [ "species_10480711" ], "modifiers": [ [ "species_10480713", "catalyst" ], [ "species_10430268", "catalyst" ], [ "species_10480715", "catalyst" ], [ "species_10480694", "catalyst" ], [ "species_10480689", "catalyst" ], [ "species_10480683", "catalyst" ], [ "species_10480681", "catalyst" ], [ "species_10480546", "catalyst" ], [ "species_10480630", "catalyst" ], [ "species_10480717", "catalyst" ], [ "species_10480719", "catalyst" ], [ "species_10480721", "catalyst" ], [ "species_10480723", "catalyst" ], [ "species_10480725", "catalyst" ], [ "species_10480727", "catalyst" ], [ "species_10480729", "catalyst" ], [ "species_10480731", "catalyst" ], [ "species_10480733", "catalyst" ], [ "species_10480738", "catalyst" ], [ "species_10480679", "catalyst" ], [ "species_10480743", "catalyst" ] ], "additional_components": [ "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "FBgn0039300", "FBgn0004867", "FBgn0261596", "FBgn0036886", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "FBgn0010408", "FBgn0039757", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "FBgn0010520", "FBgn0034743", "FBgn0033912", "FBgn0010265", "FBgn0017545", "FBgn0002590", "FBgn0030136", "FBgn0010198", "FBgn0039713", "FBgn0033699", "FBgn0030720", "FBgn0261592", "FBgn0039233" ] }, "reaction_10480933": { "compartment": "compartment_7660", "id": "reaction_10480933", "reactome": "R-DME-6791227", "name": "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480919" ], "products": [ "species_10480923" ], "modifiers": [ [ "species_10480928", "catalyst" ], [ "species_10480546", "catalyst" ], [ "species_10480595", "catalyst" ], [ "species_10480931", "catalyst" ], [ "species_10480571", "catalyst" ], [ "species_10480694", "catalyst" ], [ "species_10480418", "catalyst" ] ], "additional_components": [ "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "Q9VC94", "FBgn0039182", "Q9I7W5", "FBgn0029755", "Q9VIF6", "FBgn0032919", "Q9VEJ2", "FBgn0010926", "Q9VVK8", "FBgn0036754", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "Q9VPU8", "FBgn0020305", "Q9W4J5", "FBgn0029714", "Q95WY3", "FBgn0038964", "Q9VM69", "FBgn0026196", "Q9W1V3", "FBgn0003062", "Q8MSW9", "FBgn0053505", "Q9U3Z7", "FBgn0286786", "O46072", "FBgn0001330", "Q9W397", "FBgn0030081", "Q9V7P1", "FBgn0262560", "Q5U0X8", "FBgn0033557", "Q7JQT9", "FBgn0033454", "Q9VE98", "FBgn0038597", "Q9VFV8", "FBgn0038146", "Q07886", "FBgn0010220", "Q9W1G1", "FBgn0034933", "Q9VUR2", "FBgn0036514", "Q9VL75", "FBgn0010520", "Q9VW10", "FBgn0036886", "Q9VBY2", "FBgn0039274", "Q7JZ53", "FBgn0034232", "Q9VLK1", "FBgn0032051", "Q9W246", "FBgn0034734", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9W4R1", "FBgn0029672", "P55935", "FBgn0010408", "Q9VA91", "FBgn0039757", "Q9W3C0", "FBgn0030063", "P29327", "FBgn0261592", "P31009", "FBgn0004867", "Q9VVC9", "FBgn0036686", "P56175", "FBgn0020909", "Q9VUN7", "FBgn0036500", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q9W3K3", "FBgn0030000", "FBgn0031868", "M9PFG1", "FBgn0263605", "Q9VIG1", "FBgn0284251", "A1Z7K2", "FBgn0050349", "Q9VM75", "FBgn0086451", "Q9W4Z9", "FBgn0023527", "Q8IH00", "FBgn0261286", "Q9VMJ1", "FBgn0031764", "Q9VFJ1", "FBgn0038235", "FBgn0003742", "FBgn0262560", "FBgn0036886", "FBgn0001986" ] }, "reaction_10480467": { "compartment": "compartment_7660", "id": "reaction_10480467", "reactome": "R-DME-6791219", "name": "32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480451" ], "products": [ "species_10480408" ], "modifiers": [ [ "species_10480465", "catalyst" ], [ "species_10480449", "catalyst" ], [ "species_10480395", "catalyst" ], [ "species_10480400", "catalyst" ] ], "additional_components": [ "Q8SZY9", "FBgn0052075", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110", "Q9W3K4", "FBgn0029999", "Q8MS38", "FBgn0053217", "Q9W550", "FBgn0023514", "Q9VKQ3", "FBgn0032298", "Q9VL96", "FBgn0032138", "Q7K0Y1", "FBgn0028744", "A1ZA92", "FBgn0034073", "Q8SZY9", "FBgn0052075", "Q9VWK5", "FBgn0027603", "Q8IQH8", "FBgn0052110", "Q9W3K4", "FBgn0029999", "Q8MS38", "FBgn0053217", "Q9W550", "FBgn0023514", "A1ZA92", "FBgn0034073", "Q8MT06", "FBgn0038473", "Q9V9Z9", "FBgn0039828", "Q9VL96", "FBgn0032138", "Q9VKQ3", "FBgn0032298", "Q9VL96", "FBgn0032138", "Q7K0Y1", "FBgn0028744", "FBgn0052075", "FBgn0034073" ] }, "reaction_10468641": { "compartment": "compartment_7660", "id": "reaction_10468641", "reactome": "R-DME-3371582", "name": "HSBP1 binds HSF1 trimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468620", "species_10468637" ], "products": [ "species_10468639" ], "modifiers": [], "additional_components": [ "P22813", "FBgn0001222", "Q9VK90", "FBgn0032429", "Q9VK90", "FBgn0032429", "P22813", "FBgn0001222" ] }, "reaction_10493657": { "compartment": "compartment_70101", "id": "reaction_10493657", "reactome": "R-DME-8950724", "name": "p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493653" ], "products": [ "species_10493655" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493663": { "compartment": "compartment_70101", "id": "reaction_10493663", "reactome": "R-DME-8950780", "name": "p-Y705-STAT3 binds p-Y693-STAT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718", "species_10493632" ], "products": [ "species_10493653" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_350388": { "compartment": "compartment_70101", "id": "reaction_350388", "reactome": "R-DME-350388", "name": "ROK binds to activated RHO1:GTP", "reversible": "false", "notes": "Rho-kinase (ROK) aka Drok binds to activated Rho GTPase (RHO1:GTP) and is itself activated. The conserved Rho-binding site in ROK is the area of interaction.", "reactants": [ "species_450801", "species_350932" ], "products": [ "species_450785" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641", "Q9U779", "ROK", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_350391": { "compartment": "compartment_876", "id": "reaction_350391", "reactome": "R-DME-350391", "name": "RHO1:GTP binds to activated DAAM", "reversible": "false", "notes": "Activated Rho GTPase (RHO1:GTP) binds to activated Dishevelled Associated Activator of Morphogenesis (DAAM) complexed to Dishevelled (DSH). DAAM is a bridging factor between DSH and RHO1.", "reactants": [ "species_450703", "species_350950" ], "products": [ "species_450801" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641", "species_29438", "P48148", "Rho1", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_350396": { "compartment": "compartment_70101", "id": "reaction_350396", "reactome": "R-DME-350396", "name": "DSH binds to DAAM", "reversible": "false", "notes": "Dishevelled Associated Activator of Morphogenesis (DAAM) is autoinhibited by intramolecular interactions between its GBD and DAD domains. Dishevelled (DSH) binds to the DAD domain of DAAM and disrupts the autoinhibitory interaction, thus activating DAAM.", "reactants": [ "species_351034", "species_450734" ], "products": [ "species_450703" ], "modifiers": [], "additional_components": [ "FBgn0025641", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_10470444": { "compartment": "compartment_7660", "id": "reaction_10470444", "reactome": "R-DME-5159250", "name": "ATF7IP binds SETDB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470435", "species_10470440" ], "products": [ "species_10470442" ], "modifiers": [], "additional_components": [ "FBgn0027499", "FBgn0086908", "Q32KD2", "FBgn0086908", "Q7KMH9", "FBgn0027499" ] }, "reaction_10495537": { "compartment": "compartment_876", "id": "reaction_10495537", "reactome": "R-DME-8981353", "name": "RASA1 stimulates RAS GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495534" ], "products": [ "species_10438980", "species_10439352" ], "modifiers": [ [ "species_10495534", "catalyst" ], [ "species_10488125", "inhibitor" ] ], "additional_components": [ "Q8IR23", "FBgn0003969", "species_29438", "P08646", "RAS85D", "P08646", "RAS85D", "species_29420", "FBgn0003969", "Q8IR23", "FBgn0003969", "species_29438", "P08646", "RAS85D", "Q9VX32", "RhoGAPp190", "Q8IR23", "FBgn0003969" ] }, "reaction_10495540": { "compartment": "compartment_876", "id": "reaction_10495540", "reactome": "R-DME-8981355", "name": "RASA1 binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10439352" ], "products": [ "species_10495534" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "FBgn0003969", "Q8IR23", "FBgn0003969", "species_29438", "P08646", "RAS85D" ] }, "reaction_10487958": { "compartment": "compartment_876", "id": "reaction_10487958", "reactome": "R-DME-8848618", "name": "Activation of RAC1 by the PXN:CRK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464321", "species_29438" ], "products": [ "species_351067", "species_29420" ], "modifiers": [ [ "species_10487955", "catalyst" ] ], "additional_components": [ "P40792", "RAC1_DROME", "species_29420", "P40792", "RAC1_DROME", "species_29438", "Q9XYM0", "FBgn0024811", "Q9VKB2", "FBgn0032409", "Q2PDT4", "FBgn0041789" ] }, "reaction_10488121": { "compartment": "compartment_70101", "id": "reaction_10488121", "reactome": "R-DME-8849082", "name": "ARHGAP35 stimulates RHOA GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488118" ], "products": [ "species_29372", "species_10434904", "species_10488116" ], "modifiers": [ [ "species_10488118", "catalyst" ] ], "additional_components": [ "Q9VX32", "RhoGAPp190", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "species_29420", "Q9VX32", "RhoGAPp190", "P48148", "Rho1", "species_29438" ] }, "reaction_10488123": { "compartment": "compartment_70101", "id": "reaction_10488123", "reactome": "R-DME-8849085", "name": "ARHGAP35 binds RHOA:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434906", "species_10488116" ], "products": [ "species_10488118" ], "modifiers": [], "additional_components": [ "P48148", "Rho1", "species_29438", "Q9VX32", "RhoGAPp190", "P48148", "Rho1", "species_29438" ] }, "reaction_10488127": { "compartment": "compartment_70101", "id": "reaction_10488127", "reactome": "R-DME-8849094", "name": "ARHGAP35 binds RASA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439352", "species_10488116" ], "products": [ "species_10488125" ], "modifiers": [], "additional_components": [ "FBgn0003969", "Q9VX32", "RhoGAPp190", "Q8IR23", "FBgn0003969" ] }, "reaction_10487964": { "compartment": "compartment_70101", "id": "reaction_10487964", "reactome": "R-DME-8848829", "name": "CBL autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454432", "species_10426987" ], "products": [ "species_10487961" ], "modifiers": [ [ "species_10454432", "catalyst" ] ], "additional_components": [ "FBgn0020224", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0020224", "FBgn0020224" ] }, "reaction_10488040": { "compartment": "compartment_7660", "id": "reaction_10488040", "reactome": "R-DME-8848993", "name": "Phosphorylated KHDRBS1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488022" ], "products": [ "species_10488038" ], "modifiers": [], "additional_components": [ "O44434", "FBgn0022984", "Q9W240", "FBgn0034739", "Q9W254", "FBgn0022985", "Q9W2D0", "FBgn0034659", "Q9W224", "FBgn0034740", "Q9W249", "FBgn0034731", "Q9W255", "FBgn0022986", "Q9W254", "FBgn0022985", "Q9W255", "FBgn0022986", "Q9W2D0", "FBgn0034659", "O44434", "FBgn0022984", "Q9W224", "FBgn0034740", "Q9W240", "FBgn0034739", "Q9W249", "FBgn0034731" ] }, "reaction_10469023": { "compartment": "compartment_876", "id": "reaction_10469023", "reactome": "R-DME-3791155", "name": "Laminin-322 degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443411" ], "products": [ "species_10469021" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "P11046", "FBgn0261800", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "FBgn0035049" ] }, "reaction_10479128": { "compartment": "compartment_5460", "id": "reaction_10479128", "reactome": "R-DME-5696408", "name": "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696409", "species_113521" ], "products": [ "species_113548", "species_5693978", "species_113556" ], "modifiers": [ [ "species_10479125", "catalyst" ] ], "additional_components": [ "Q9VU95", "FBgn0036381" ] }, "reaction_10466188": { "compartment": "compartment_984", "id": "reaction_10466188", "reactome": "R-DME-2534248", "name": "DCN (decorin) degradation by MMP2, MMP3, MMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465552" ], "products": [ "species_10466183", "species_10466185" ], "modifiers": [ [ "species_10459266", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "FBgn0028872", "FBgn0035049" ] }, "reaction_10459276": { "compartment": "compartment_984", "id": "reaction_10459276", "reactome": "R-DME-1454781", "name": "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459252", "species_10459247" ], "products": [ "species_10459274" ], "modifiers": [], "additional_components": [ "FBgn0035049", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9W122", "FBgn0035049" ] }, "reaction_10469689": { "compartment": "compartment_876", "id": "reaction_10469689", "reactome": "R-DME-4224014", "name": "E-cadherin degradation by ADAM10, ADAM15", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469032" ], "products": [ "species_10469040", "species_10469036" ], "modifiers": [ [ "species_10469686", "catalyst" ] ], "additional_components": [ "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "Q6QU65", "FBgn0265140", "Q9VJW9", "FBgn0259984" ] }, "reaction_10460413": { "compartment": "compartment_984", "id": "reaction_10460413", "reactome": "R-DME-1604690", "name": "Activation of MMP9 intermediate form by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460226" ], "products": [ "species_10459272", "species_10460411" ], "modifiers": [ [ "species_10459252", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460058": { "compartment": "compartment_984", "id": "reaction_10460058", "reactome": "R-DME-1592297", "name": "Full activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460055" ], "products": [ "species_10459252" ], "modifiers": [ [ "species_10459266", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460378": { "compartment": "compartment_17963", "id": "reaction_10460378", "reactome": "R-DME-1602484", "name": "Activation of proMMP11 by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460376" ], "products": [ "species_10459260" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0004509" ] }, "reaction_10460185": { "compartment": "compartment_984", "id": "reaction_10460185", "reactome": "R-DME-1592316", "name": "Initial activation of proMMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460060" ], "products": [ "species_10460064", "species_10460062" ], "modifiers": [ [ "species_10460182", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "Q9VUG2", "FBgn0036436", "P13582", "ProEA", "Q9I7V4", "FBgn0042098", "M9NDV6", "FBgn0036817", "Q9VUF0", "FBgn0036427", "Q8MLV8", "FBgn0050287", "C5WLM7", "FBgn0050414", "Q9VR15", "FBgn0031619", "Q9W2C8", "FBgn0034661", "Q8IRK6", "FBgn0050288", "A1ZA44", "FBgn0050083", "Q9VK10", "FBgn0284244", "Q9VZS9", "FBgn0053160", "Q8IRK5", "FBgn0050289", "A1ZA38", "FBgn0050088", "Q9VA87", "FBgn0039759", "Q9VXC7", "FBgn0030775", "Q7KVM8", "FBgn0069056", "A0A4D6K1E7", "FBgn0039272", "Q9VA44", "FBgn0039798", "Q9VWD8", "FBgn0031058", "Q7KVM3", "FBgn0034666", "Q9V3Z2", "FBgn0037515" ] }, "reaction_10460409": { "compartment": "compartment_876", "id": "reaction_10460409", "reactome": "R-DME-1604368", "name": "Autocatalytic activation of bound proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460396" ], "products": [ "species_10460050", "species_10460406" ], "modifiers": [ [ "species_10460396", "catalyst" ] ], "additional_components": [ "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10460374": { "compartment": "compartment_984", "id": "reaction_10460374", "reactome": "R-DME-1602473", "name": "Autocatalytic activation of MMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460062" ], "products": [ "species_10460371", "species_10460055" ], "modifiers": [ [ "species_10460062", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460053": { "compartment": "compartment_984", "id": "reaction_10460053", "reactome": "R-DME-1592278", "name": "Autocatalytic activation of proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460048" ], "products": [ "species_10460050", "species_10459266" ], "modifiers": [ [ "species_10460048", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460437": { "compartment": "compartment_984", "id": "reaction_10460437", "reactome": "R-DME-1604741", "name": "Initial activation of proMMP13 by MMP14 (MT1-MMP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460380" ], "products": [ "species_10460435", "species_10460422" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460403": { "compartment": "compartment_876", "id": "reaction_10460403", "reactome": "R-DME-1604360", "name": "Initial activation of proMMP2 by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460388" ], "products": [ "species_10460392", "species_10460396" ], "modifiers": [ [ "species_10460187", "catalyst" ], [ "species_10460401", "inhibitor" ] ], "additional_components": [ "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "FBgn0035049", "FBgn0026562" ] }, "reaction_10460433": { "compartment": "compartment_984", "id": "reaction_10460433", "reactome": "R-DME-1604732", "name": "Autocatalytic activation of proMMP13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460422" ], "products": [ "species_10459254", "species_10460426" ], "modifiers": [ [ "species_10460422", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460369": { "compartment": "compartment_17963", "id": "reaction_10460369", "reactome": "R-DME-1602466", "name": "Activation of MT-MMPs by FURIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460353" ], "products": [ "species_10460367" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "Q9W122", "FBgn0035049", "Q9W122", "FBgn0035049", "FBgn0004509" ] }, "reaction_10460559": { "compartment": "compartment_17963", "id": "reaction_10460559", "reactome": "R-DME-1605825", "name": "MT-MMPs are sorted to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460367" ], "products": [ "species_10460557" ], "modifiers": [], "additional_components": [ "Q9W122", "FBgn0035049", "Q9W122", "FBgn0035049" ] }, "reaction_10460334": { "compartment": "compartment_984", "id": "reaction_10460334", "reactome": "R-DME-1602454", "name": "proMMP9 binds TIMP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460224", "species_10452419" ], "products": [ "species_10460332" ], "modifiers": [], "additional_components": [ "FBgn0035049", "FBgn0025879", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10460460": { "compartment": "compartment_984", "id": "reaction_10460460", "reactome": "R-DME-1604752", "name": "Initial activation of proMMP13 by MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460380" ], "products": [ "species_10460439", "species_10460424" ], "modifiers": [ [ "species_10460457", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q9W122", "FBgn0035049" ] }, "reaction_10460394": { "compartment": "compartment_984", "id": "reaction_10460394", "reactome": "R-DME-1604359", "name": "Initial activation of proMMP2 by MMP1, 7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460386" ], "products": [ "species_10460048", "species_10460392" ], "modifiers": [ [ "species_10459252", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460231": { "compartment": "compartment_984", "id": "reaction_10460231", "reactome": "R-DME-1592436", "name": "Initial activation of proMMP9 by MMPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460224" ], "products": [ "species_10460226", "species_10460228" ], "modifiers": [ [ "species_10459252", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460390": { "compartment": "compartment_876", "id": "reaction_10460390", "reactome": "R-DME-1604350", "name": "MMP14:TIMP2 binds proMMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460386", "species_10460191" ], "products": [ "species_10460388" ], "modifiers": [], "additional_components": [ "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10460420": { "compartment": "compartment_984", "id": "reaction_10460420", "reactome": "R-DME-1604731", "name": "Autocatalytic activation of MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460197" ], "products": [ "species_10460417", "species_10459256" ], "modifiers": [ [ "species_10460197", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "FBgn0035049", "FBgn0035049" ] }, "reaction_10460193": { "compartment": "compartment_876", "id": "reaction_10460193", "reactome": "R-DME-1592349", "name": "MMP14 (MT1-MMP) binds TIMP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460187", "species_10460189" ], "products": [ "species_10460191" ], "modifiers": [], "additional_components": [ "FBgn0035049", "FBgn0025879", "Q9VH14", "FBgn0025879", "Q9W122", "FBgn0035049" ] }, "reaction_10469030": { "compartment": "compartment_984", "id": "reaction_10469030", "reactome": "R-DME-3791319", "name": "NID1 degradation by MMP19", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465781" ], "products": [ "species_10469025", "species_10469027" ], "modifiers": [ [ "species_10459264", "catalyst" ] ], "additional_components": [ "FBgn0000119", "FBgn0000119", "FBgn0000119", "FBgn0035049" ] }, "reaction_10466181": { "compartment": "compartment_876", "id": "reaction_10466181", "reactome": "R-DME-2533950", "name": "Fibronectin degradation by MMP14, TMPRSS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451" ], "products": [ "species_10459980" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "FBgn0035049" ] }, "reaction_10469045": { "compartment": "compartment_876", "id": "reaction_10469045", "reactome": "R-DME-3828025", "name": "DCN (decorin) degradation by MMP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465552" ], "products": [ "species_10466183", "species_10466185" ], "modifiers": [ [ "species_10460187", "catalyst" ] ], "additional_components": [ "FBgn0028872", "FBgn0028872", "FBgn0028872", "FBgn0035049" ] }, "reaction_10468964": { "compartment": "compartment_876", "id": "reaction_10468964", "reactome": "R-DME-3788061", "name": "Fibronectin degradation by ADAM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451" ], "products": [ "species_10468949" ], "modifiers": [ [ "species_10468961", "catalyst" ] ], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140" ] }, "reaction_10469043": { "compartment": "compartment_876", "id": "reaction_10469043", "reactome": "R-DME-3827958", "name": "E-cadherin degradation by MMP9, KLK7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469032" ], "products": [ "species_10469040", "species_10469036" ], "modifiers": [ [ "species_10459272", "catalyst" ] ], "additional_components": [ "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "species_74016", "Q9VJB6", "FBgn0262018", "FBgn0035049" ] }, "reaction_10460002": { "compartment": "compartment_984", "id": "reaction_10460002", "reactome": "R-DME-1566981", "name": "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451" ], "products": [ "species_10459980" ], "modifiers": [ [ "species_10459999", "catalyst" ] ], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q9W122", "FBgn0035049" ] }, "reaction_10434812": { "compartment": "compartment_7660", "id": "reaction_10434812", "reactome": "R-DME-113407", "name": "DSIF complex binds to RNA Pol II (hypophosphorylated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434771", "species_10434653" ], "products": [ "species_10434773" ], "modifiers": [], "additional_components": [ "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10434778": { "compartment": "compartment_7660", "id": "reaction_10434778", "reactome": "R-DME-112383", "name": "Hypophosphorylation of RNA Pol II CTD by FCP1P protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434658", "species_10429250", "species_10431174" ], "products": [ "species_10434771", "species_10431174" ], "modifiers": [ [ "species_10434658", "catalyst" ] ], "additional_components": [ "FBgn0035026", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "FBgn0035026" ] }, "reaction_10434810": { "compartment": "compartment_7660", "id": "reaction_10434810", "reactome": "R-DME-113402", "name": "Formation of DSIF:NELF:early elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434773", "species_10434646", "species_30595" ], "products": [ "species_10434775", "species_30595" ], "modifiers": [], "additional_components": [ "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "species_110577", "species_113592", "species_29494", "species_29438" ] }, "reaction_10446741": { "compartment": "compartment_70101", "id": "reaction_10446741", "reactome": "R-DME-391266", "name": "Association of CCT/TriC with sphingosine kinase 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446737", "species_10446693" ], "products": [ "species_10446739" ], "modifiers": [], "additional_components": [ "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "FBgn0030300", "Q9VYY8", "FBgn0030300", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019" ] }, "reaction_10487280": { "compartment": "compartment_70101", "id": "reaction_10487280", "reactome": "R-DME-6814120", "name": "ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487278" ], "products": [ "species_29372", "species_10487272" ], "modifiers": [], "additional_components": [ "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_113592", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105" ] }, "reaction_10488352": { "compartment": "compartment_70101", "id": "reaction_10488352", "reactome": "R-DME-8850529", "name": "RGS proteins bind GNB5 and CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488348", "species_10488332" ], "products": [ "species_10488350" ], "modifiers": [], "additional_components": [ "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927" ] }, "reaction_10487330": { "compartment": "compartment_70101", "id": "reaction_10487330", "reactome": "R-DME-6814409", "name": "CK2 phosphorylates PDCL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487328" ], "products": [ "species_29370", "species_10487289" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "FBgn0036519", "FBgn0036519", "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10488356": { "compartment": "compartment_70101", "id": "reaction_10488356", "reactome": "R-DME-8850534", "name": "PDCL promotes G-protein beta 5 folding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488354" ], "products": [ "species_10488332", "species_10487289" ], "modifiers": [], "additional_components": [ "Q9VUR7", "FBgn0036519", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "FBgn0036519" ] }, "reaction_10488360": { "compartment": "compartment_70101", "id": "reaction_10488360", "reactome": "R-DME-8850539", "name": "Release of GNB5:RGS dimers from CCT/TRiC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488350" ], "products": [ "species_10446737", "species_10488358" ], "modifiers": [], "additional_components": [ "Q9W3J1", "FBgn0030011", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W3J1", "FBgn0030011", "Q9VXA3", "FBgn0024941", "M9PHI8", "FBgn0259927" ] }, "reaction_10487274": { "compartment": "compartment_70101", "id": "reaction_10487274", "reactome": "R-DME-6814119", "name": "TRiC/CCT binds unfolded G-protein beta subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434577", "species_10446737" ], "products": [ "species_10487272" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105" ] }, "reaction_10488330": { "compartment": "compartment_70101", "id": "reaction_10488330", "reactome": "R-DME-8850527", "name": "PDCL releases folded G-beta from TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488328" ], "products": [ "species_10446737", "species_10487334" ], "modifiers": [], "additional_components": [ "P29829", "FBgn0004623", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "Q9VUR7", "FBgn0036519", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "Q9VUR7", "FBgn0036519" ] }, "reaction_10487340": { "compartment": "compartment_70101", "id": "reaction_10487340", "reactome": "R-DME-6814418", "name": "PDCL promotes formation of G-beta:G-gamma heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434560", "species_10487334" ], "products": [ "species_10487338" ], "modifiers": [], "additional_components": [ "P38040", "FBgn0004921", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "Q9VUR7", "FBgn0036519", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VUR7", "FBgn0036519" ] }, "reaction_10488364": { "compartment": "compartment_70101", "id": "reaction_10488364", "reactome": "R-DME-8850560", "name": "G-protein alpha releases G-protein heterotrimer from PDCL ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487338", "species_10434215" ], "products": [ "species_10488362", "species_10487289" ], "modifiers": [], "additional_components": [ "P29829", "FBgn0004623", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VUR7", "FBgn0036519", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P29829", "FBgn0004623", "P26308", "FBgn0001105", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P38040", "FBgn0004921", "FBgn0036519" ] }, "reaction_10487293": { "compartment": "compartment_70101", "id": "reaction_10487293", "reactome": "R-DME-6814121", "name": "PDCL binds G-protein beta and TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487289", "species_10487272" ], "products": [ "species_10487291" ], "modifiers": [], "additional_components": [ "FBgn0036519", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9VUR7", "FBgn0036519" ] }, "reaction_10487295": { "compartment": "compartment_70101", "id": "reaction_10487295", "reactome": "R-DME-6814124", "name": "ATP binds G-protein beta associated TRiC/CCT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487272" ], "products": [ "species_10487278", "species_29370" ], "modifiers": [], "additional_components": [ "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_29370", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105", "Q9W392", "FBgn0030086", "Q9VHL2", "FBgn0037632", "Q9VXQ5", "FBgn0027329", "P12613", "FBgn0003676", "Q7KKI0", "FBgn0010621", "Q7K3J0", "FBgn0284436", "species_113592", "Q9VK69", "FBgn0032444", "P48605", "FBgn0015019", "P26308", "FBgn0001105" ] }, "reaction_10435035": { "compartment": "compartment_70101", "id": "reaction_10435035", "reactome": "R-DME-139941", "name": "Binding of IP3 to IP3 receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435028", "species_114520" ], "products": [ "species_10435030" ], "modifiers": [], "additional_components": [ "P29993", "FBgn0010051", "species_114520", "species_74016", "P29993", "FBgn0010051" ] }, "reaction_10448282": { "compartment": "compartment_876", "id": "reaction_10448282", "reactome": "R-DME-426209", "name": "DAG activation of TRPC channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448278", "species_114519" ], "products": [ "species_10448280" ], "modifiers": [], "additional_components": [ "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "species_114519", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861" ] }, "reaction_10448164": { "compartment": "compartment_70101", "id": "reaction_10448164", "reactome": "R-DME-425861", "name": "Activation of Protein Kinase C novel isoforms", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440788", "species_114519" ], "products": [ "species_10448162" ], "modifiers": [], "additional_components": [ "P83099", "FBgn0259680", "P13678", "FBgn0003093", "species_114519", "P83099", "FBgn0259680", "P13678", "FBgn0003093" ] }, "reaction_10448320": { "compartment": "compartment_70101", "id": "reaction_10448320", "reactome": "R-DME-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_114519" ], "products": [ "species_76108", "species_29370" ], "modifiers": [ [ "species_10448317", "catalyst" ] ], "additional_components": [ "Q7K579", "FBgn0020930", "A8JQ65", "FBgn0085413", "Q09103", "FBgn0261549", "Q01583", "FBgn0085390" ] }, "reaction_10492391": { "compartment": "compartment_7660", "id": "reaction_10492391", "reactome": "R-DME-8938231", "name": "RUNX1:CBFB binds CREBBP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447242", "species_10489794" ], "products": [ "species_10492389" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617" ] }, "reaction_10435599": { "compartment": "compartment_70101", "id": "reaction_10435599", "reactome": "R-DME-156910", "name": "Formation of eEF1B complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435585", "species_10435590", "species_10435595" ], "products": [ "species_10435597" ], "modifiers": [], "additional_components": [ "FBgn0028737", "FBgn0032198", "FBgn0029176", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737" ] }, "reaction_10435616": { "compartment": "compartment_70101", "id": "reaction_10435616", "reactome": "R-DME-156930", "name": "GTP-binding activates eEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10435612" ], "products": [ "species_10435614" ], "modifiers": [], "additional_components": [ "FBgn0000559", "P13060", "FBgn0000559", "species_29438" ] }, "reaction_10435606": { "compartment": "compartment_70101", "id": "reaction_10435606", "reactome": "R-DME-156913", "name": "Regeneration of eEF1A:GTP by eEF1B activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10435601", "species_10435597" ], "products": [ "species_10435603", "species_10435580" ], "modifiers": [ [ "species_10435597", "catalyst" ] ], "additional_components": [ "P08736", "FBgn0284245", "P05303", "FBgn0000557", "species_29420", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737", "species_29420", "P08736", "FBgn0284245", "P05303", "FBgn0000557", "species_29438", "Q9NJH0", "FBgn0029176", "Q9VL18", "FBgn0032198", "O96827", "FBgn0028737" ] }, "reaction_10498785": { "compartment": "compartment_7660", "id": "reaction_10498785", "reactome": "R-DME-9709547", "name": "ESTG binds ESR2:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1254400", "species_10492512" ], "products": [ "species_10492514" ], "modifiers": [], "additional_components": [ "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "species_374146" ] }, "reaction_10492498": { "compartment": "compartment_7660", "id": "reaction_10492498", "reactome": "R-DME-8939201", "name": "ESR dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492488" ], "products": [ "species_10492496" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "species_374146", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10492518": { "compartment": "compartment_7660", "id": "reaction_10492518", "reactome": "R-DME-8939204", "name": "ESTG binds ESR1:chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492508", "species_1254400" ], "products": [ "species_10492510" ], "modifiers": [], "additional_components": [ "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "species_374146", "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592" ] }, "reaction_10497254": { "compartment": "compartment_7660", "id": "reaction_10497254", "reactome": "R-DME-9038029", "name": "27-hydroxysterol binds ESR1, ESR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445260", "species_9024328" ], "products": [ "species_10497252" ], "modifiers": [], "additional_components": [ "FBgn0035849", "species_9024328", "Q8WS79", "FBgn0035849" ] }, "reaction_10495875": { "compartment": "compartment_7660", "id": "reaction_10495875", "reactome": "R-DME-9008270", "name": "NCOA1 binds ESR1:estrogen:TGFA gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495867", "species_10440440" ], "products": [ "species_10495873" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "FBgn0041092", "M9ND53", "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974" ] }, "reaction_10495879": { "compartment": "compartment_7660", "id": "reaction_10495879", "reactome": "R-DME-9008285", "name": "NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495869", "species_10458126" ], "products": [ "species_10495877" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092", "FBgn0261617", "M9MS40", "FBgn0261617", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092" ] }, "reaction_10496935": { "compartment": "compartment_7660", "id": "reaction_10496935", "reactome": "R-DME-9023840", "name": "HATs and coactivators are recruited to the CTSD gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476674", "species_10496924", "species_10445380", "species_10465316", "species_10496931", "species_10458126", "species_10496929" ], "products": [ "species_10496933" ], "modifiers": [], "additional_components": [ "FBgn0041092", "species_374146", "Q8WS79", "FBgn0035849", "FBgn0037109", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "FBgn0029711", "FBgn0261617", "FBgn0029711", "Q9W4J8", "FBgn0029711", "M9MS40", "FBgn0261617", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "Q9VP05", "FBgn0037109", "species_374146", "Q8WS79", "FBgn0035849", "M9ND53", "FBgn0041092" ] }, "reaction_10496587": { "compartment": "compartment_7660", "id": "reaction_10496587", "reactome": "R-DME-9018499", "name": "ESR1:ESTG and EP300 are recruited to TFF3 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496583", "species_10458587", "species_10458126" ], "products": [ "species_10496585" ], "modifiers": [], "additional_components": [ "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "species_374146", "Q8WS79", "FBgn0035849", "FBgn0261617", "M9MS40", "FBgn0261617", "species_374146", "Q8WS79", "FBgn0035849", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223" ] }, "reaction_10496075": { "compartment": "compartment_7660", "id": "reaction_10496075", "reactome": "R-DME-9009526", "name": "CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496071", "species_10447247" ], "products": [ "species_10496073" ], "modifiers": [], "additional_components": [ "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "FBgn0037770", "Q9VH48", "FBgn0037770", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10496077": { "compartment": "compartment_7660", "id": "reaction_10496077", "reactome": "R-DME-9009533", "name": "TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431317", "species_10431112", "species_10496069" ], "products": [ "species_10496071" ], "modifiers": [], "additional_components": [ "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10496079": { "compartment": "compartment_7660", "id": "reaction_10496079", "reactome": "R-DME-9009536", "name": "DDX5 binds ESR1:estrogen:TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429510", "species_10496067" ], "products": [ "species_10496069" ], "modifiers": [], "additional_components": [ "FBgn0035720", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720" ] }, "reaction_10496081": { "compartment": "compartment_7660", "id": "reaction_10496081", "reactome": "R-DME-9009541", "name": "ESR1 binds to TFF1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495863", "species_10496065" ], "products": [ "species_10496067" ], "modifiers": [], "additional_components": [ "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974" ] }, "reaction_10496945": { "compartment": "compartment_7660", "id": "reaction_10496945", "reactome": "R-DME-9023860", "name": "Histone acetyltransferases are recruited to the TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496941", "species_10496937" ], "products": [ "species_10496943" ], "modifiers": [], "additional_components": [ "Q9VH48", "FBgn0037770", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VGW7", "FBgn0037834", "M9MS40", "FBgn0261617", "M9ND53", "FBgn0041092", "Q960X4", "FBgn0026080", "Q9VTZ1", "FBgn0020388", "M9MS40", "FBgn0261617", "M9ND53", "FBgn0041092", "Q960X4", "FBgn0026080", "Q9VTZ1", "FBgn0020388", "Q9VH48", "FBgn0037770", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VGW7", "FBgn0037834" ] }, "reaction_10496947": { "compartment": "compartment_7660", "id": "reaction_10496947", "reactome": "R-DME-9023861", "name": "PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467587", "species_10496071" ], "products": [ "species_10496939" ], "modifiers": [], "additional_components": [ "FBgn0037834", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P14734", "FBgn0000659", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8MZI3", "FBgn0035720", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VGW7", "FBgn0037834" ] }, "reaction_10496213": { "compartment": "compartment_7660", "id": "reaction_10496213", "reactome": "R-DME-9012315", "name": "ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496205", "species_10496209" ], "products": [ "species_10496211" ], "modifiers": [], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855" ] }, "reaction_10496951": { "compartment": "compartment_7660", "id": "reaction_10496951", "reactome": "R-DME-9023884", "name": "NCOA1 recruits EP300 to TGFA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458126", "species_10495873" ], "products": [ "species_10496949" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9ND53", "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9MS40", "FBgn0261617" ] }, "reaction_10491863": { "compartment": "compartment_7660", "id": "reaction_10491863", "reactome": "R-DME-8931981", "name": "RUNX1 binds ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458587", "species_10489794" ], "products": [ "species_10491861" ], "modifiers": [], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10496218": { "compartment": "compartment_7660", "id": "reaction_10496218", "reactome": "R-DME-9012319", "name": "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10496211" ], "products": [ "species_113582", "species_10496215" ], "modifiers": [ [ "species_10496211", "catalyst" ] ], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "species_374146", "Q8WS79", "FBgn0035849", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855" ] }, "reaction_10495871": { "compartment": "compartment_7660", "id": "reaction_10495871", "reactome": "R-DME-9008258", "name": "NCOA3 binds ESR1:estrogen:TFGA gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476674", "species_10495867" ], "products": [ "species_10495869" ], "modifiers": [], "additional_components": [ "FBgn0041092", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "Q8WS79", "FBgn0035849", "CHEBI:142773", "species_176575", "species_176619", "CHEBI:27974", "M9ND53", "FBgn0041092" ] }, "reaction_10496898": { "compartment": "compartment_876", "id": "reaction_10496898", "reactome": "R-DME-9021600", "name": "G-proteins dissociate from plasma-membrane estrogen receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496896" ], "products": [ "species_10465520", "species_10434579", "species_10437767" ], "modifiers": [], "additional_components": [ "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P20353", "FBgn0001104" ] }, "reaction_10496900": { "compartment": "compartment_876", "id": "reaction_10496900", "reactome": "R-DME-9021601", "name": "Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465520", "species_10445744" ], "products": [ "species_10496896" ], "modifiers": [], "additional_components": [ "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146" ] }, "reaction_10496903": { "compartment": "compartment_876", "id": "reaction_10496903", "reactome": "R-DME-9021609", "name": "ESR-associated SRC autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496890", "species_113592" ], "products": [ "species_10465522", "species_29370" ], "modifiers": [ [ "species_10496890", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146" ] }, "reaction_10496875": { "compartment": "compartment_20699", "id": "reaction_10496875", "reactome": "R-DME-9021072", "name": "ZDHHC7, ZDHHC21 palmitoylate ESR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_10496865" ], "products": [ "species_10471012", "species_10496857", "species_76194" ], "modifiers": [ [ "species_10496872", "catalyst" ] ], "additional_components": [ "Q8WS79", "FBgn0035849", "Q8IQW5", "FBgn0031037", "Q8IQW5", "FBgn0031037", "FBgn0035849", "Q9I7L7", "FBgn0042133", "Q9VBM6", "FBgn0039368", "Q9W251", "FBgn0034729", "Q8IQN9", "FBgn0036670", "Q9VBM5", "FBgn0039369", "Q9VBM8", "FBgn0039366", "Q0IGS7", "FBgn0033815", "Q9VBM4", "FBgn0039370", "Q9VBM7", "FBgn0039367", "Q7K3T4", "FBgn0034057" ] }, "reaction_10497874": { "compartment": "compartment_876", "id": "reaction_10497874", "reactome": "R-DME-9634584", "name": "Estrogen receptor binds IGF1R and SHC1 in response to estrogen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431840", "species_10497870", "species_10497757" ], "products": [ "species_10497872" ], "modifiers": [], "additional_components": [ "FBgn0015296", "P09208", "InR", "species_374146", "Q8WS79", "FBgn0035849", "species_374146", "Q8WS79", "FBgn0035849", "P09208", "InR", "Q9V3C8", "FBgn0015296" ] }, "reaction_10496888": { "compartment": "compartment_876", "id": "reaction_10496888", "reactome": "R-DME-9021170", "name": "Estrogen stimulates dimerization of plasma membrane estrogen receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496878", "species_374146" ], "products": [ "species_10496886" ], "modifiers": [], "additional_components": [ "FBgn0035849", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10497818": { "compartment": "compartment_70101", "id": "reaction_10497818", "reactome": "R-DME-9632182", "name": "PRMT1 methylates ESRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5279190", "species_10497809" ], "products": [ "species_10496878", "species_71285" ], "modifiers": [ [ "species_10497815", "catalyst" ], [ "species_374146", "catalyst" ] ], "additional_components": [ "FBgn0035849", "FBgn0035849", "FBgn0037834" ] }, "reaction_10497851": { "compartment": "compartment_876", "id": "reaction_10497851", "reactome": "R-DME-9633044", "name": "ESR binds STRN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496886", "species_10465518" ], "products": [ "species_10497013" ], "modifiers": [], "additional_components": [ "species_374146", "Q8WS79", "FBgn0035849", "FBgn0044323", "D3DML3", "FBgn0044323", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10496892": { "compartment": "compartment_876", "id": "reaction_10496892", "reactome": "R-DME-9021596", "name": "Membrane estrogen receptors bind SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465520", "species_10438881" ], "products": [ "species_10496890" ], "modifiers": [ [ "species_10437767", "catalyst" ], [ "species_10434579", "catalyst" ] ], "additional_components": [ "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "FBgn0262733", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10441093": { "compartment": "compartment_7660", "id": "reaction_10441093", "reactome": "R-DME-199298", "name": "AKT phosphorylates CREB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441081" ], "products": [ "species_113582", "species_10441084" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0265784", "FBgn0265784" ] }, "reaction_10497837": { "compartment": "compartment_7660", "id": "reaction_10497837", "reactome": "R-DME-9632873", "name": "p-S10 CDKN1B translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497833" ], "products": [ "species_10497835" ], "modifiers": [ [ "species_10437629", "catalyst" ], [ "species_10440931", "catalyst" ] ], "additional_components": [ "FBgn0010316", "FBgn0010316", "FBgn0020497", "P40417", "FBgn0003256" ] }, "reaction_10497725": { "compartment": "compartment_7660", "id": "reaction_10497725", "reactome": "R-DME-9624526", "name": "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441099" ], "products": [ "species_113582", "species_10441113" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10497727": { "compartment": "compartment_7660", "id": "reaction_10497727", "reactome": "R-DME-9624527", "name": "AKT-phosphorylated FOXO3 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441113" ], "products": [ "species_10497563" ], "modifiers": [], "additional_components": [] }, "reaction_10497759": { "compartment": "compartment_876", "id": "reaction_10497759", "reactome": "R-DME-9625814", "name": "SPHK1 phosphorylates sphingosine in response to E2 stimulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1606609" ], "products": [ "species_5218688" ], "modifiers": [ [ "species_10446693", "catalyst" ], [ "species_10497757", "catalyst" ] ], "additional_components": [ "FBgn0030300", "species_374146", "Q8WS79", "FBgn0035849" ] }, "reaction_10497042": { "compartment": "compartment_7660", "id": "reaction_10497042", "reactome": "R-DME-9029551", "name": "NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497000", "species_10440440" ], "products": [ "species_10497040" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "FBgn0041092", "M9ND53", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633" ] }, "reaction_10496998": { "compartment": "compartment_7660", "id": "reaction_10496998", "reactome": "R-DME-9024326", "name": "Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9024383", "species_10496994" ], "products": [ "species_10496996" ], "modifiers": [], "additional_components": [ "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122" ] }, "reaction_10497046": { "compartment": "compartment_7660", "id": "reaction_10497046", "reactome": "R-DME-9029561", "name": "NCOA1 recruits EP300 to the ABCA1 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458126", "species_10497040" ], "products": [ "species_10497044" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9ND53", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "M9ND53", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "M9MS40", "FBgn0261617" ] }, "reaction_10497002": { "compartment": "compartment_7660", "id": "reaction_10497002", "reactome": "R-DME-9024334", "name": "Co-repressor complex dissociates from the transcription unit of the ABCA1 gene ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496996" ], "products": [ "species_10496990", "species_10497000" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "Q7JQT8", "FBgn0033122", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633" ] }, "reaction_10497054": { "compartment": "compartment_7660", "id": "reaction_10497054", "reactome": "R-DME-9029580", "name": "NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497050", "species_10440440" ], "products": [ "species_10497052" ], "modifiers": [], "additional_components": [ "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "FBgn0041092", "P20153", "FBgn0003964", "P34021", "FBgn0000546", "CHEBI:34310", "CHEBI:67237", "species_9024328", "CHEBI:41633", "M9ND53", "FBgn0041092" ] }, "reaction_10474430": { "compartment": "compartment_70101", "id": "reaction_10474430", "reactome": "R-DME-5634104", "name": "SUMO-CRABP2:atRA translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471595" ], "products": [ "species_10471616" ], "modifiers": [], "additional_components": [ "species_5334816", "Q8INK3", "FBgn0037913", "Q8INK3", "FBgn0037913", "species_5334816" ] }, "reaction_10471597": { "compartment": "compartment_70101", "id": "reaction_10471597", "reactome": "R-DME-5334827", "name": "SUMO-CRABP2 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471593", "species_5334816" ], "products": [ "species_10471595" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_5334816", "Q8INK3", "FBgn0037913" ] }, "reaction_10442349": { "compartment": "compartment_5460", "id": "reaction_10442349", "reactome": "R-DME-203946", "name": "PDK isoforms phosphorylate lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428865", "species_113593" ], "products": [ "species_113581", "species_10442333" ], "modifiers": [ [ "species_10442338", "catalyst" ], [ "species_29362", "catalyst" ], [ "species_113559", "catalyst" ], [ "species_10441275", "catalyst" ], [ "species_113557", "inhibitor" ], [ "species_10442347", "inhibitor" ] ], "additional_components": [ "Q9VM14", "FBgn0283658", "species_113596", "Q9VVL7", "FBgn0036762", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "Q9VM14", "FBgn0283658", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "species_113596", "Q9VVL7", "FBgn0036762", "FBgn0017558", "species_5334816", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P91622", "FBgn0017558" ] }, "reaction_10441277": { "compartment": "compartment_70101", "id": "reaction_10441277", "reactome": "R-DME-200406", "name": "CPT1A,B transfers PALM to CAR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_549207", "species_200993" ], "products": [ "species_201034", "species_76194" ], "modifiers": [ [ "species_10441263", "catalyst" ], [ "species_10441275", "catalyst" ], [ "species_29508", "inhibitor" ] ], "additional_components": [ "FBgn0261862", "species_5334816", "P20153", "FBgn0003964", "P13055", "FBgn0000568" ] }, "reaction_10474428": { "compartment": "compartment_7660", "id": "reaction_10474428", "reactome": "R-DME-5634103", "name": "SUMO-CRABP2 dissociates from atRA:RAR:RXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471618" ], "products": [ "species_10474426", "species_10471614" ], "modifiers": [], "additional_components": [ "P13055", "FBgn0000568", "P20153", "FBgn0003964", "Q8INK3", "FBgn0037913", "species_5334816", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "species_5334816", "FBgn0037913" ] }, "reaction_10471620": { "compartment": "compartment_7660", "id": "reaction_10471620", "reactome": "R-DME-5334854", "name": "RAR:RXR binds SUMO-CRABP2:atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471616", "species_10471612" ], "products": [ "species_10471618" ], "modifiers": [], "additional_components": [ "Q8INK3", "FBgn0037913", "species_5334816", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P20153", "FBgn0003964", "Q8INK3", "FBgn0037913", "species_5334816" ] }, "reaction_10473631": { "compartment": "compartment_70101", "id": "reaction_10473631", "reactome": "R-DME-5622134", "name": "CRABP1 binds atRA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471971", "species_5334816" ], "products": [ "species_10471973" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_5334816", "Q8INK3", "FBgn0037913" ] }, "reaction_10472006": { "compartment": "compartment_70101", "id": "reaction_10472006", "reactome": "R-DME-5362721", "name": "RDH5,RDH11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30927", "species_29360" ], "products": [ "species_70106", "species_32737", "species_73473" ], "modifiers": [ [ "species_10465841", "catalyst" ] ], "additional_components": [ "FBgn0000056" ] }, "reaction_10472004": { "compartment": "compartment_70101", "id": "reaction_10472004", "reactome": "R-DME-5362564", "name": "ADH1A,1C,4 oxidise atROL to atRAL in vitro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10472001", "catalyst" ] ], "additional_components": [ "P46415", "FBgn0011768", "species_1562550" ] }, "reaction_10472051": { "compartment": "compartment_70101", "id": "reaction_10472051", "reactome": "R-DME-5419165", "name": "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10472048", "catalyst" ] ], "additional_components": [ "Q9VE80", "FBgn0038610", "Q8SZ46", "FBgn0286852", "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043", "Q9VRJ4", "FBgn0035588" ] }, "reaction_10473201": { "compartment": "compartment_70101", "id": "reaction_10473201", "reactome": "R-DME-5615668", "name": "AKR1C3 reduces atRAL to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_975599" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10471968": { "compartment": "compartment_70101", "id": "reaction_10471968", "reactome": "R-DME-5362518", "name": "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975599", "species_29360" ], "products": [ "species_70106", "species_975622", "species_73473" ], "modifiers": [ [ "species_10471965", "catalyst" ] ], "additional_components": [ "Q9VIG6", "FBgn0032910", "Q9VCR9", "FBgn0039043", "Q9VKB8", "FBgn0032405", "Q9W3K9", "FBgn0029994", "Q9VCS2", "FBgn0039040", "Q9VR28", "FBgn0031630", "P91615", "FBgn0000056" ] }, "reaction_10436933": { "compartment": "compartment_70101", "id": "reaction_10436933", "reactome": "R-DME-165162", "name": "Phosphorylation of TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436925" ], "products": [ "species_10436930", "species_29370" ], "modifiers": [ [ "species_10433712", "catalyst" ] ], "additional_components": [ "FBgn0005198", "FBgn0005198", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10436948": { "compartment": "compartment_70101", "id": "reaction_10436948", "reactome": "R-DME-165182", "name": "Phosphorylation of complexed TSC2 by PKB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436942" ], "products": [ "species_10436946", "species_29370" ], "modifiers": [ [ "species_10433712", "catalyst" ] ], "additional_components": [ "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10436958": { "compartment": "compartment_17938", "id": "reaction_10436958", "reactome": "R-DME-165195", "name": "GTP loading by Rheb", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10436954" ], "products": [ "species_29420", "species_10436956" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29420", "Q9VND8", "Rheb", "species_29438" ] }, "reaction_10445901": { "compartment": "compartment_70101", "id": "reaction_10445901", "reactome": "R-DME-380949", "name": "AMPK is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10441308" ], "products": [ "species_29372", "species_10441300" ], "modifiers": [ [ "species_10445898", "catalyst" ] ], "additional_components": [ "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VBF9", "FBgn0039421", "Q961C5", "FBgn0086361" ] }, "reaction_10450613": { "compartment": "compartment_876", "id": "reaction_10450613", "reactome": "R-DME-447074", "name": "AMPK phosphorylates Raptor in the mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040", "species_113592" ], "products": [ "species_29370", "species_10437109" ], "modifiers": [ [ "species_10445887", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10445892": { "compartment": "compartment_70101", "id": "reaction_10445892", "reactome": "R-DME-380930", "name": "Phosphorylated AMPK binds AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441308", "species_76577" ], "products": [ "species_10445887" ], "modifiers": [], "additional_components": [ "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10445890": { "compartment": "compartment_70101", "id": "reaction_10445890", "reactome": "R-DME-380927", "name": "p-AMPK phosphorylates TSC1:TSC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436942" ], "products": [ "species_29370", "species_10445885" ], "modifiers": [ [ "species_10445887", "catalyst" ] ], "additional_components": [ "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10445906": { "compartment": "compartment_70101", "id": "reaction_10445906", "reactome": "R-DME-380979", "name": "RHEB in mTORC1:RHEB:GTP hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040" ], "products": [ "species_29372", "species_10445903" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10445885", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317" ] }, "reaction_10474811": { "compartment": "compartment_70101", "id": "reaction_10474811", "reactome": "R-DME-5653974", "name": "Ragulator binds Rag dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437032", "species_10437004" ], "products": [ "species_10437034" ], "modifiers": [], "additional_components": [ "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10475738": { "compartment": "compartment_17938", "id": "reaction_10475738", "reactome": "R-DME-5672843", "name": "AKT1S1 (PRAS40) binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040", "species_10437061" ], "products": [ "species_10437063" ], "modifiers": [], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "FBgn0267824", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10498482": { "compartment": "compartment_70101", "id": "reaction_10498482", "reactome": "R-DME-9679044", "name": "FKBP1A binds sirolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678687", "species_10437068" ], "products": [ "species_10437070" ], "modifiers": [], "additional_components": [ "FBgn0013954", "P48375", "FBgn0013954" ] }, "reaction_10437111": { "compartment": "compartment_17938", "id": "reaction_10437111", "reactome": "R-DME-165718", "name": "mTORC1 phosphorylation of RPS6KB1 (S6K)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437089", "species_113592" ], "products": [ "species_29370", "species_10437099" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10437059", "catalyst" ], [ "species_10437070", "inhibitor" ], [ "species_10437109", "inhibitor" ] ], "additional_components": [ "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472", "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P48375", "FBgn0013954", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691" ] }, "reaction_10437077": { "compartment": "compartment_70101", "id": "reaction_10437077", "reactome": "R-DME-165708", "name": "Dissociation of phosphorylated 4EBP1 from eIF4E", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437048" ], "products": [ "species_10430485", "species_10437046" ], "modifiers": [], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709" ] }, "reaction_10437122": { "compartment": "compartment_70101", "id": "reaction_10437122", "reactome": "R-DME-165726", "name": "Phosphorylation of Ribosomal protein S6 by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430332" ], "products": [ "species_29370", "species_10437119" ], "modifiers": [ [ "species_10437099", "catalyst" ] ], "additional_components": [ "FBgn0261592", "FBgn0261592", "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472" ] }, "reaction_10437136": { "compartment": "compartment_70101", "id": "reaction_10437136", "reactome": "R-DME-165766", "name": "Phosphorylation and activation of eIF4G by activated S6K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430497", "species_113592" ], "products": [ "species_29370", "species_10437134" ], "modifiers": [ [ "species_10437099", "catalyst" ] ], "additional_components": [ "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VWQ2", "FBgn0283473", "Q94533", "FBgn0283472" ] }, "reaction_10437072": { "compartment": "compartment_17938", "id": "reaction_10437072", "reactome": "R-DME-165692", "name": "Phosphorylation of 4E-BP1 by activated mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430525" ], "products": [ "species_29370", "species_10437048" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10437059", "catalyst" ], [ "species_10437063", "inhibitor" ], [ "species_10437070", "inhibitor" ] ], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P48375", "FBgn0013954" ] }, "reaction_10474809": { "compartment": "compartment_17938", "id": "reaction_10474809", "reactome": "R-DME-5653968", "name": "Ragulator:Rag dimers:SLC38A9 bind mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437036", "species_10436975" ], "products": [ "species_10437038" ], "modifiers": [], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10475736": { "compartment": "compartment_17938", "id": "reaction_10475736", "reactome": "R-DME-5672828", "name": "mTORC1 phosphorylates AKT1S1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437059", "species_113592" ], "products": [ "species_29370", "species_10475733" ], "modifiers": [ [ "species_10437059", "catalyst" ] ], "additional_components": [ "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10474807": { "compartment": "compartment_70101", "id": "reaction_10474807", "reactome": "R-DME-5653957", "name": "Rag dimer formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437030", "species_10437017" ], "products": [ "species_10437032" ], "modifiers": [], "additional_components": [ "species_29420", "Q7K519", "FBgn0033272", "Q9VHJ4", "FBgn0037647", "species_29438", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10474805": { "compartment": "compartment_17938", "id": "reaction_10474805", "reactome": "R-DME-5653936", "name": "Formation of Ragulator complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436992", "species_10436997", "species_10436982", "species_10437002", "species_10436987" ], "products": [ "species_10437004" ], "modifiers": [], "additional_components": [ "FBgn0032642", "FBgn0035469", "FBgn0036932", "FBgn0026090", "FBgn0034350", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642" ] }, "reaction_10494954": { "compartment": "compartment_70101", "id": "reaction_10494954", "reactome": "R-DME-8952726", "name": "SLC38A9 transports L-Arg from lysosomal lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428011" ], "products": [ "species_29468" ], "modifiers": [ [ "species_10437036", "catalyst" ] ], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10437042": { "compartment": "compartment_70101", "id": "reaction_10437042", "reactome": "R-DME-165680", "name": "Formation of active mTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436956", "species_10437038" ], "products": [ "species_10437040" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29438", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10475729": { "compartment": "compartment_17938", "id": "reaction_10475729", "reactome": "R-DME-5672824", "name": "Phosphorylated AKT1S1:mTORC1 binds YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437057", "species_10432008" ], "products": [ "species_10437059" ], "modifiers": [], "additional_components": [ "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "P29310", "14-3-3zeta", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10445389": { "compartment": "compartment_17938", "id": "reaction_10445389", "reactome": "R-DME-377186", "name": "Activated Akt1 phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437063" ], "products": [ "species_10437057", "species_29370" ], "modifiers": [ [ "species_10441842", "catalyst" ] ], "additional_components": [ "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10438766": { "compartment": "compartment_17963", "id": "reaction_10438766", "reactome": "R-DME-177107", "name": "Secretion and activation of the latent large complex of TGF-beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437824" ], "products": [ "species_10437860" ], "modifiers": [], "additional_components": [ "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10437884": { "compartment": "compartment_17941", "id": "reaction_10437884", "reactome": "R-DME-170850", "name": "Phosphorylated SMAD2/3 dissociates from TGFBR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437880" ], "products": [ "species_10437882", "species_10437838" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "FBgn0025800" ] }, "reaction_10437893": { "compartment": "compartment_171062", "id": "reaction_10437893", "reactome": "R-DME-170868", "name": "Activated type I receptor phosphorylates SMAD2/3 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437890", "species_113592" ], "products": [ "species_29370", "species_10437880" ], "modifiers": [ [ "species_10437890", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300", "O96660", "FBgn0025800", "Q7K9H6", "FBgn0026369", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300" ] }, "reaction_10437826": { "compartment": "compartment_20699", "id": "reaction_10437826", "reactome": "R-DME-170844", "name": "Latent TGF-beta-1 is cleaved by furin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437814" ], "products": [ "species_10437824" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "FBgn0004509" ] }, "reaction_10437967": { "compartment": "compartment_70101", "id": "reaction_10437967", "reactome": "R-DME-173542", "name": "SMURF2 ubiquitinates SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437962", "species_10426987" ], "products": [ "species_10437960", "species_10437964" ], "modifiers": [ [ "species_10437962", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "Q9V853", "FBgn0029006", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0029006", "O96660", "FBgn0025800", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O96660", "FBgn0025800", "Q9V853", "FBgn0029006" ] }, "reaction_10465227": { "compartment": "compartment_70101", "id": "reaction_10465227", "reactome": "R-DME-2176452", "name": "Degradation of ubiquitinated SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437964" ], "products": [], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10465225": { "compartment": "compartment_70101", "id": "reaction_10465225", "reactome": "R-DME-2176445", "name": "SMURF2 binds SMAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437960", "species_10437886" ], "products": [ "species_10437962" ], "modifiers": [], "additional_components": [ "FBgn0029006", "FBgn0025800", "O96660", "FBgn0025800", "Q9V853", "FBgn0029006" ] }, "reaction_10465352": { "compartment": "compartment_70101", "id": "reaction_10465352", "reactome": "R-DME-2187382", "name": "Degradation of ubiquitinated SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465345" ], "products": [], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O96660", "FBgn0025800" ] }, "reaction_10465350": { "compartment": "compartment_70101", "id": "reaction_10465350", "reactome": "R-DME-2187375", "name": "SMAD3 binds STUB1 (CHIP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437888", "species_10456460" ], "products": [ "species_10465343" ], "modifiers": [], "additional_components": [ "FBgn0025800", "FBgn0027052", "Q9XYW6", "FBgn0027052", "O96660", "FBgn0025800" ] }, "reaction_10465365": { "compartment": "compartment_70101", "id": "reaction_10465365", "reactome": "R-DME-2187405", "name": "MTMR4 binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465358", "species_10437838" ], "products": [ "species_10465360" ], "modifiers": [], "additional_components": [ "FBgn0030735", "FBgn0025800", "O96660", "FBgn0025800", "Q7YU03", "FBgn0030735" ] }, "reaction_10465348": { "compartment": "compartment_70101", "id": "reaction_10465348", "reactome": "R-DME-2187368", "name": "STUB1 (CHIP) ubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10465343" ], "products": [ "species_10465345", "species_10456460" ], "modifiers": [ [ "species_10465343", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XYW6", "FBgn0027052", "O96660", "FBgn0025800", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O96660", "FBgn0025800", "FBgn0027052", "Q9XYW6", "FBgn0027052", "O96660", "FBgn0025800" ] }, "reaction_10465363": { "compartment": "compartment_70101", "id": "reaction_10465363", "reactome": "R-DME-2187401", "name": "MTMR4 dephosphorylates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465360", "species_29356" ], "products": [ "species_29372", "species_10465358", "species_10437886" ], "modifiers": [ [ "species_10465360", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "Q7YU03", "FBgn0030735", "FBgn0030735", "FBgn0025800", "O96660", "FBgn0025800", "Q7YU03", "FBgn0030735" ] }, "reaction_10465037": { "compartment": "compartment_204883", "id": "reaction_10465037", "reactome": "R-DME-2160931", "name": "Disassembly of tight junctions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465035" ], "products": [], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V853", "FBgn0029006", "M9PBE1", "FBgn0032796", "P48148", "Rho1", "A1Z9X0", "FBgn0261854", "Q0KHR3", "FBgn0000163", "O97111", "FBgn0026192", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "A1Z7L8", "FBgn0011300" ] }, "reaction_10454143": { "compartment": "compartment_70101", "id": "reaction_10454143", "reactome": "R-DME-870479", "name": "USP9X (FAM) binds to ubiquitinated SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454130", "species_10454139" ], "products": [ "species_10454132" ], "modifiers": [], "additional_components": [ "FBgn0005632", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P55824", "FBgn0005632" ] }, "reaction_10454141": { "compartment": "compartment_7660", "id": "reaction_10454141", "reactome": "R-DME-870477", "name": "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454137" ], "products": [ "species_10454139" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O62609", "FBgn0011655", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655" ] }, "reaction_10465341": { "compartment": "compartment_7660", "id": "reaction_10465341", "reactome": "R-DME-2187330", "name": "PARP1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437946", "species_10465325" ], "products": [ "species_10465327" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0010247", "P35875", "FBgn0010247", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465339": { "compartment": "compartment_7660", "id": "reaction_10465339", "reactome": "R-DME-2187325", "name": "PARP1 ADP-ribosylates SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_427523", "species_10465327" ], "products": [ "species_427497", "species_10465336", "species_10465325" ], "modifiers": [ [ "species_10465327", "catalyst" ] ], "additional_components": [ "P35875", "FBgn0010247", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "FBgn0010247", "P35875", "FBgn0010247", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10437976": { "compartment": "compartment_7660", "id": "reaction_10437976", "reactome": "R-DME-173545", "name": "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437946" ], "products": [], "modifiers": [ [ "species_10437973", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q9Y165", "FBgn0027609", "P25867", "eff" ] }, "reaction_10454135": { "compartment": "compartment_70101", "id": "reaction_10454135", "reactome": "R-DME-870437", "name": "USP9X (FAM) deubiquitinates SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10454132" ], "products": [ "species_10454130", "species_10437831", "species_10426987" ], "modifiers": [ [ "species_10454132", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P55824", "FBgn0005632", "FBgn0005632", "FBgn0011655", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O62609", "FBgn0011655", "P55824", "FBgn0005632" ] }, "reaction_10465265": { "compartment": "compartment_7660", "id": "reaction_10465265", "reactome": "R-DME-2179276", "name": "SMURF2 monoubiquitinates SMAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10465258" ], "products": [ "species_10437940", "species_10465256", "species_10465262" ], "modifiers": [ [ "species_10465258", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9V853", "FBgn0029006", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0011655", "FBgn0029006", "O96660", "FBgn0025800", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9V853", "FBgn0029006", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465294": { "compartment": "compartment_7660", "id": "reaction_10465294", "reactome": "R-DME-2186767", "name": "Degradation of ubiquitinated SKI/SKIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465292" ], "products": [], "modifiers": [], "additional_components": [ "Q00G30", "FBgn0085450", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11" ] }, "reaction_10442669": { "compartment": "compartment_7660", "id": "reaction_10442669", "reactome": "R-DME-209055", "name": "PPM1A dephosphorylates nuclear SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10442662" ], "products": [ "species_113550", "species_10442660", "species_10437940", "species_10442664" ], "modifiers": [ [ "species_10442662", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421", "FBgn0011655", "FBgn0025800", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421" ] }, "reaction_10465260": { "compartment": "compartment_7660", "id": "reaction_10465260", "reactome": "R-DME-2179274", "name": "SMURF2 binds SMAD3 phosphorylated in the linker region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465235", "species_10465256" ], "products": [ "species_10465258" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0029006", "Q9V853", "FBgn0029006", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465356": { "compartment": "compartment_70101", "id": "reaction_10465356", "reactome": "R-DME-2187395", "name": "Dephosphorylated SMAD2/3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442664" ], "products": [ "species_10437886" ], "modifiers": [], "additional_components": [ "FBgn0025800", "FBgn0025800" ] }, "reaction_10465354": { "compartment": "compartment_7660", "id": "reaction_10465354", "reactome": "R-DME-2187388", "name": "PPM1A protein phosphatase binds phosphorylated SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442660", "species_10437946" ], "products": [ "species_10442662" ], "modifiers": [], "additional_components": [ "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q961C5", "FBgn0086361", "Q9VBF9", "FBgn0039421" ] }, "reaction_10465254": { "compartment": "compartment_7660", "id": "reaction_10465254", "reactome": "R-DME-2176503", "name": "Degradation of SMAD2/3:SMAD4 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465250" ], "products": [], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465252": { "compartment": "compartment_7660", "id": "reaction_10465252", "reactome": "R-DME-2176502", "name": "NEDD4L ubiquitinates SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10465246" ], "products": [ "species_10465250", "species_10465244" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9VVI3", "FBgn0259174", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0259174" ] }, "reaction_10465248": { "compartment": "compartment_7660", "id": "reaction_10465248", "reactome": "R-DME-2176491", "name": "NEDD4L binds phosphorylated linker region of SMAD2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465235", "species_10465244" ], "products": [ "species_10465246" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0259174", "Q9VVI3", "FBgn0259174", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10464907": { "compartment": "compartment_7660", "id": "reaction_10464907", "reactome": "R-DME-2127257", "name": "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458009", "species_10437946" ], "products": [ "species_10464905" ], "modifiers": [], "additional_components": [ "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q24472", "Rbf", "Q24318", "FBgn0011763", "O77051", "FBgn0024371" ] }, "reaction_10465242": { "compartment": "compartment_7660", "id": "reaction_10465242", "reactome": "R-DME-2176475", "name": "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437946" ], "products": [ "species_113582", "species_10465235" ], "modifiers": [ [ "species_10465239", "catalyst" ] ], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "P25008", "FBgn0004597", "Q9VT57", "FBgn0015618", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10465290": { "compartment": "compartment_7660", "id": "reaction_10465290", "reactome": "R-DME-2186643", "name": "MEN1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465286", "species_10437946" ], "products": [ "species_10465288" ], "modifiers": [], "additional_components": [ "FBgn0031885", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q9VM47", "FBgn0031885" ] }, "reaction_10464521": { "compartment": "compartment_70101", "id": "reaction_10464521", "reactome": "R-DME-2031355", "name": "WWTR1 binds SMAD2/3:SMAD4 heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437844", "species_10464315" ], "products": [ "species_10464519" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q45VV3", "yki", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10465320": { "compartment": "compartment_7660", "id": "reaction_10465320", "reactome": "R-DME-2187309", "name": "SMAD2/3:SMAD4 heterotrimer binds SP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465316", "species_10437946" ], "products": [ "species_10465318" ], "modifiers": [], "additional_components": [ "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364" ] }, "reaction_10471447": { "compartment": "compartment_13231", "id": "reaction_10471447", "reactome": "R-DME-5252001", "name": "ATP1B4 binds SNW1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471443", "species_10429914" ], "products": [ "species_10471445" ], "modifiers": [], "additional_components": [ "Q9V3Q7", "FBgn0038690", "Q7KT77", "FBgn0053310", "Q24048", "FBgn0015777", "Q24046", "FBgn0015776", "M9PDX8", "FBgn0032946", "Q9VDY7", "FBgn0038691", "FBgn0004856", "P39736", "FBgn0004856", "Q9V3Q7", "FBgn0038690", "Q7KT77", "FBgn0053310", "Q24048", "FBgn0015777", "Q24046", "FBgn0015776", "M9PDX8", "FBgn0032946", "Q9VDY7", "FBgn0038691" ] }, "reaction_10464867": { "compartment": "compartment_70101", "id": "reaction_10464867", "reactome": "R-DME-2106579", "name": "WWTR1:SMAD translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464519" ], "products": [ "species_10464865" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q45VV3", "yki", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10441485": { "compartment": "compartment_70101", "id": "reaction_10441485", "reactome": "R-DME-201422", "name": "Phospho-R-Smad1/5/8 forms a complex with Co-Smad", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441476", "species_10437831" ], "products": [ "species_10441483" ], "modifiers": [], "additional_components": [ "FBgn0011648", "FBgn0011655", "O62609", "FBgn0011655", "P42003", "FBgn0011648" ] }, "reaction_10441565": { "compartment": "compartment_13231", "id": "reaction_10441565", "reactome": "R-DME-201472", "name": "The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441483" ], "products": [ "species_10441493" ], "modifiers": [], "additional_components": [ "O62609", "FBgn0011655", "P42003", "FBgn0011648", "P42003", "FBgn0011648", "O62609", "FBgn0011655" ] }, "reaction_10441563": { "compartment": "compartment_984", "id": "reaction_10441563", "reactome": "R-DME-201457", "name": "BMP2 binds to the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441506", "species_10441524" ], "products": [ "species_10441526" ], "modifiers": [], "additional_components": [ "P07713", "FBgn0000490", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "P07713", "FBgn0000490" ] }, "reaction_10441499": { "compartment": "compartment_7660", "id": "reaction_10441499", "reactome": "R-DME-201425", "name": "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441493" ], "products": [], "modifiers": [ [ "species_10437973", "catalyst" ] ], "additional_components": [ "P42003", "FBgn0011648", "O62609", "FBgn0011655", "Q9Y165", "FBgn0027609", "P25867", "eff" ] }, "reaction_10441561": { "compartment": "compartment_17941", "id": "reaction_10441561", "reactome": "R-DME-201453", "name": "Phospho-R-Smad1/5/8 dissociates from the receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441557" ], "products": [ "species_10441476", "species_10441559" ], "modifiers": [], "additional_components": [ "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716" ] }, "reaction_10441497": { "compartment": "compartment_7660", "id": "reaction_10441497", "reactome": "R-DME-201423", "name": "SKI complexes with the Smad complex, suppressing BMP2 signalling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441493", "species_10437951" ], "products": [ "species_10441495" ], "modifiers": [], "additional_components": [ "P42003", "FBgn0011648", "O62609", "FBgn0011655", "FBgn0085450", "Q00G30", "FBgn0085450", "P42003", "FBgn0011648", "O62609", "FBgn0011655" ] }, "reaction_10441671": { "compartment": "compartment_70101", "id": "reaction_10441671", "reactome": "R-DME-201648", "name": "An anchoring protein, Endofin, recruits R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441555", "species_10441539", "species_10441544" ], "products": [ "species_10441567" ], "modifiers": [], "additional_components": [ "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "FBgn0011648", "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716" ] }, "reaction_10441958": { "compartment": "compartment_876", "id": "reaction_10441958", "reactome": "R-DME-202604", "name": "Formation of a heteromeric BMP receptor complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441522", "species_10441515" ], "products": [ "species_10441524" ], "modifiers": [], "additional_components": [ "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179" ] }, "reaction_10441542": { "compartment": "compartment_70101", "id": "reaction_10441542", "reactome": "R-DME-201443", "name": "Type II receptor phosphorylates type I receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441526" ], "products": [ "species_10441539", "species_29370" ], "modifiers": [ [ "species_10441526", "catalyst" ] ], "additional_components": [ "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "P07713", "FBgn0000490", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "Q9VMT1", "FBgn0003716", "M9PE88", "FBgn0024179", "P07713", "FBgn0000490" ] }, "reaction_10441570": { "compartment": "compartment_876", "id": "reaction_10441570", "reactome": "R-DME-201476", "name": "Activated type I receptor phosphorylates R-Smad1/5/8 directly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441567" ], "products": [ "species_29370", "species_10441557" ], "modifiers": [ [ "species_10441567", "catalyst" ] ], "additional_components": [ "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716", "P42003", "FBgn0011648", "Q7K9H6", "FBgn0026369", "P07713", "FBgn0000490", "M9PE88", "FBgn0024179", "Q9VMT1", "FBgn0003716" ] }, "reaction_10441553": { "compartment": "compartment_70101", "id": "reaction_10441553", "reactome": "R-DME-201445", "name": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441544" ], "products": [], "modifiers": [ [ "species_10437960", "catalyst" ] ], "additional_components": [ "FBgn0011648", "FBgn0029006" ] }, "reaction_10457846": { "compartment": "compartment_876", "id": "reaction_10457846", "reactome": "R-DME-1181149", "name": "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10457836" ], "products": [ "species_10457843", "species_29370" ], "modifiers": [ [ "species_10457836", "catalyst" ] ], "additional_components": [ "O61643", "FBgn0024913", "A1Z7L8", "FBgn0011300", "O61643", "FBgn0024913", "A1Z7L8", "FBgn0011300", "O61643", "FBgn0024913", "A1Z7L8", "FBgn0011300" ] }, "reaction_10459937": { "compartment": "compartment_70101", "id": "reaction_10459937", "reactome": "R-DME-1549526", "name": "Phosphorylation of SMAD2/3 by Activin:Activin Receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10437886" ], "products": [ "species_29370", "species_10437838" ], "modifiers": [ [ "species_10459934", "catalyst" ] ], "additional_components": [ "FBgn0025800", "FBgn0025800", "A1Z7L8", "FBgn0011300", "O61643", "FBgn0024913" ] }, "reaction_10493361": { "compartment": "compartment_7660", "id": "reaction_10493361", "reactome": "R-DME-8944349", "name": "TLE tetramers bind TCF/LEF at WNT promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493357", "species_10468252" ], "products": [ "species_10493359" ], "modifiers": [], "additional_components": [ "Q8IMA8", "FBgn0085432", "P16371", "GRO", "P16371", "GRO", "Q8IMA8", "FBgn0085432" ] }, "reaction_10471580": { "compartment": "compartment_7660", "id": "reaction_10471580", "reactome": "R-DME-5334050", "name": "TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468226", "species_10467421" ], "products": [ "species_10471578" ], "modifiers": [], "additional_components": [ "FBgn0085432", "FBgn0020496", "O46036", "FBgn0020496", "Q8IMA8", "FBgn0085432" ] }, "reaction_10470019": { "compartment": "compartment_7660", "id": "reaction_10470019", "reactome": "R-DME-4641229", "name": "TLE oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468236" ], "products": [ "species_10468252" ], "modifiers": [], "additional_components": [ "P16371", "GRO" ] }, "reaction_10440586": { "compartment": "compartment_70101", "id": "reaction_10440586", "reactome": "R-DME-195280", "name": "Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440579" ], "products": [ "species_10440579" ], "modifiers": [], "additional_components": [ "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn" ] }, "reaction_10464922": { "compartment": "compartment_70101", "id": "reaction_10464922", "reactome": "R-DME-2130286", "name": "Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464912", "species_10426987" ], "products": [ "species_10464916" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn" ] }, "reaction_10440607": { "compartment": "compartment_70101", "id": "reaction_10440607", "reactome": "R-DME-195300", "name": "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440594", "species_113592" ], "products": [ "species_29370", "species_10440570" ], "modifiers": [ [ "species_10440594", "catalyst" ] ], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_10440604": { "compartment": "compartment_70101", "id": "reaction_10440604", "reactome": "R-DME-195287", "name": "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440601" ], "products": [ "species_29370", "species_10440590" ], "modifiers": [ [ "species_10440601", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10440616": { "compartment": "compartment_70101", "id": "reaction_10440616", "reactome": "R-DME-195318", "name": "Phosphorylation of beta-catenin at Ser45 by CK1 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440611", "species_113592" ], "products": [ "species_29370", "species_10440601" ], "modifiers": [ [ "species_10440611", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10440597": { "compartment": "compartment_70101", "id": "reaction_10440597", "reactome": "R-DME-195283", "name": "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440590" ], "products": [ "species_10440594", "species_29370" ], "modifiers": [ [ "species_10440590", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10440584": { "compartment": "compartment_70101", "id": "reaction_10440584", "reactome": "R-DME-195275", "name": "Phosphorylation of APC component of the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440570" ], "products": [ "species_10440579", "species_29370" ], "modifiers": [ [ "species_10440570", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10464920": { "compartment": "compartment_70101", "id": "reaction_10464920", "reactome": "R-DME-2130282", "name": "Degradation of ubiquitinated beta catenin by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464916" ], "products": [ "species_10442677", "species_10464918", "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10471110": { "compartment": "compartment_70101", "id": "reaction_10471110", "reactome": "R-DME-5229343", "name": "AXIN is phosphorylated in the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441755" ], "products": [ "species_10440560", "species_29370" ], "modifiers": [ [ "species_10441755", "catalyst" ] ], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650" ] }, "reaction_10440613": { "compartment": "compartment_70101", "id": "reaction_10440613", "reactome": "R-DME-195304", "name": "Association of beta-catenin with the destruction complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440560", "species_10440609" ], "products": [ "species_10440611" ], "modifiers": [], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "Q9V407", "phospho-Axn" ] }, "reaction_10464914": { "compartment": "compartment_70101", "id": "reaction_10464914", "reactome": "R-DME-2130279", "name": "Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440579", "species_10442677" ], "products": [ "species_10464912" ], "modifiers": [], "additional_components": [ "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a", "P83101", "FBgn0046332", "P18431", "sgg", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650", "P18824", "arm", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9V407", "phospho-Axn" ] }, "reaction_10469710": { "compartment": "compartment_70101", "id": "reaction_10469710", "reactome": "R-DME-4332363", "name": "Autophosphorylation and activation of CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10469702" ], "products": [ "species_10469697", "species_29370" ], "modifiers": [ [ "species_10469702", "catalyst" ] ], "additional_components": [ "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10469834": { "compartment": "compartment_70101", "id": "reaction_10469834", "reactome": "R-DME-4551465", "name": "Translocation of NFATC1:CaN:CaM to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469828" ], "products": [ "species_10469832" ], "modifiers": [], "additional_components": [ "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_74016", "Q24214", "FBgn0015614", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_1222611", "species_1562550" ] }, "reaction_10469706": { "compartment": "compartment_70101", "id": "reaction_10469706", "reactome": "R-DME-4332359", "name": "Active calmodulin binds CAMK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10449351" ], "products": [ "species_10469702" ], "modifiers": [ [ "species_10469704", "inhibitor" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10469736": { "compartment": "compartment_7660", "id": "reaction_10469736", "reactome": "R-DME-4411373", "name": "NLK translocates to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469730" ], "products": [ "species_10469734" ], "modifiers": [], "additional_components": [ "A0A4D6K823", "FBgn0011817", "A0A4D6K823", "FBgn0011817" ] }, "reaction_10469751": { "compartment": "compartment_7660", "id": "reaction_10469751", "reactome": "R-DME-4411383", "name": "NLK phosphorylates TCF/LEF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10469738" ], "products": [ "species_113582", "species_10469748" ], "modifiers": [ [ "species_10469734", "catalyst" ] ], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "Q8IMA8", "FBgn0085432", "P18824", "arm", "A0A4D6K823", "FBgn0011817" ] }, "reaction_10469558": { "compartment": "compartment_876", "id": "reaction_10469558", "reactome": "R-DME-3965447", "name": "G-protein subunits dissociate from WNT:FZD complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469553" ], "products": [ "species_10469538", "species_10434579", "species_10469543" ], "modifiers": [], "additional_components": [ "P16378", "FBgn0001122", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "FBgn0001122" ] }, "reaction_10446854": { "compartment": "compartment_70101", "id": "reaction_10446854", "reactome": "R-DME-398040", "name": "Gbeta:gamma activation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10434175" ], "products": [ "species_10446852" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "FBgn0004611", "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10469830": { "compartment": "compartment_70101", "id": "reaction_10469830", "reactome": "R-DME-4551451", "name": "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10464038", "species_10464071" ], "products": [ "species_29372", "species_10469828" ], "modifiers": [ [ "species_10464071", "catalyst" ] ], "additional_components": [ "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614" ] }, "reaction_10469556": { "compartment": "compartment_876", "id": "reaction_10469556", "reactome": "R-DME-3965444", "name": "WNT:FZD complex promotes G-protein nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10469549" ], "products": [ "species_10469553", "species_29420" ], "modifiers": [ [ "species_10469549", "catalyst" ] ], "additional_components": [ "P16378", "FBgn0001122", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16378", "FBgn0001122", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16378", "FBgn0001122", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VVX3", "FZ2", "P18537", "FZ", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343" ] }, "reaction_10466948": { "compartment": "compartment_70101", "id": "reaction_10466948", "reactome": "R-DME-2730872", "name": "Activation of Calcineurin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10464021", "species_74016" ], "products": [ "species_10464071" ], "modifiers": [], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614" ] }, "reaction_10469700": { "compartment": "compartment_70101", "id": "reaction_10469700", "reactome": "R-DME-4332358", "name": "Dissociation of CaM and CAMK2 autophosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469697", "species_113592" ], "products": [ "species_10434387", "species_29370", "species_10469695" ], "modifiers": [ [ "species_10469697", "catalyst" ] ], "additional_components": [ "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q00168", "FBgn0264607", "Q00168", "FBgn0264607", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10446865": { "compartment": "compartment_70101", "id": "reaction_10446865", "reactome": "R-DME-398193", "name": "PLC beta-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10446852", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10469087": { "compartment": "compartment_70101", "id": "reaction_10469087", "reactome": "R-DME-3858475", "name": "ppDVL recruits RAC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441719", "species_10469083" ], "products": [ "species_10469085" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "P40792", "RAC1_DROME", "species_29438", "P51140", "phospho-dsh" ] }, "reaction_10469101": { "compartment": "compartment_876", "id": "reaction_10469101", "reactome": "R-DME-3858482", "name": "DVL is recruited to the receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441768", "species_10469097" ], "products": [ "species_10469099" ], "modifiers": [], "additional_components": [ "P09615", "WG", "Q9VFX1", "FBgn0038134", "P40589", "FBgn0010453", "P18537", "FZ", "P09615", "WG", "Q9VFX1", "FBgn0038134", "P40589", "FBgn0010453", "P18537", "FZ", "P51140", "phospho-dsh" ] }, "reaction_10470350": { "compartment": "compartment_876", "id": "reaction_10470350", "reactome": "R-DME-5138432", "name": "DVL2 is phosphorylated by PKC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10470343" ], "products": [ "species_29370", "species_10470345" ], "modifiers": [ [ "species_10470347", "catalyst" ] ], "additional_components": [ "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343" ] }, "reaction_10470362": { "compartment": "compartment_876", "id": "reaction_10470362", "reactome": "R-DME-5138441", "name": "WNT5A-FZD4 recruits DVL2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441761", "species_10470339" ], "products": [ "species_10470343" ], "modifiers": [], "additional_components": [ "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh" ] }, "reaction_10470360": { "compartment": "compartment_876", "id": "reaction_10470360", "reactome": "R-DME-5138433", "name": "p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470354", "species_10470345", "species_10447483" ], "products": [ "species_10470358" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319" ] }, "reaction_10470341": { "compartment": "compartment_876", "id": "reaction_10470341", "reactome": "R-DME-5099899", "name": "WNT5A binds FZD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469528", "species_10468078" ], "products": [ "species_10470339" ], "modifiers": [], "additional_components": [ "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "FBgn0010194", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343" ] }, "reaction_10470402": { "compartment": "compartment_20592", "id": "reaction_10470402", "reactome": "R-DME-5138459", "name": "WNT5A:FZD4 is endocytosed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470358" ], "products": [ "species_10470400", "species_10447483" ], "modifiers": [], "additional_components": [ "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P29742", "FBgn0000319", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120" ] }, "reaction_10470415": { "compartment": "compartment_876", "id": "reaction_10470415", "reactome": "R-DME-5140741", "name": "WNT5A binds FZD and ROR receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470411", "species_10468078" ], "products": [ "species_10470413" ], "modifiers": [], "additional_components": [ "Q9VVX3", "FZ2", "P18537", "FZ", "Q24488", "FBgn0010407", "FBgn0010194", "P28466", "FBgn0010194", "Q9VVX3", "FZ2", "P18537", "FZ", "Q24488", "FBgn0010407" ] }, "reaction_10470429": { "compartment": "compartment_20592", "id": "reaction_10470429", "reactome": "R-DME-5140747", "name": "FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470413" ], "products": [ "species_10470427" ], "modifiers": [ [ "species_10470354", "catalyst" ] ], "additional_components": [ "P28466", "FBgn0010194", "Q9VVX3", "FZ2", "P18537", "FZ", "Q24488", "FBgn0010407", "P28466", "FBgn0010194", "Q24488", "FBgn0010407", "Q9VVX3", "FZ2", "P18537", "FZ", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "P29742", "FBgn0000319" ] }, "reaction_10468030": { "compartment": "compartment_20699", "id": "reaction_10468030", "reactome": "R-DME-3247840", "name": "WLS binds WNT ligands in the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468016", "species_10467932" ], "products": [ "species_10468028" ], "modifiers": [], "additional_components": [ "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "FBgn0036141", "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902" ] }, "reaction_10468026": { "compartment": "compartment_171062", "id": "reaction_10468026", "reactome": "R-DME-3247839", "name": "Retromer associates with WLS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467923", "species_10467928", "species_10467918" ], "products": [ "species_10467930" ], "modifiers": [], "additional_components": [ "FBgn0036141", "FBgn0038065", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q9VG51", "FBgn0038065", "Q95ST2", "FBgn0036141" ] }, "reaction_10468088": { "compartment": "compartment_20699", "id": "reaction_10468088", "reactome": "R-DME-3247849", "name": "WLS dissociates from retromer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467934" ], "products": [ "species_10467928", "species_10467932", "species_10467918" ], "modifiers": [], "additional_components": [ "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q95ST2", "FBgn0036141", "Q9VG51", "FBgn0038065", "FBgn0038065", "FBgn0036141", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411" ] }, "reaction_10468023": { "compartment": "compartment_17963", "id": "reaction_10468023", "reactome": "R-DME-3247837", "name": "WNT ligands traffic to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467992" ], "products": [ "species_10468016" ], "modifiers": [ [ "species_10468021", "catalyst" ] ], "additional_components": [ "P28465", "FBgn0004360", "P28466", "FBgn0010194", "Q9VM26", "FBgn0031902", "P09615", "WG", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "FBgn0264389" ] }, "reaction_10468086": { "compartment": "compartment_171062", "id": "reaction_10468086", "reactome": "R-DME-3247847", "name": "WLS is endocytosed to the early endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468032" ], "products": [ "species_10467923" ], "modifiers": [], "additional_components": [ "FBgn0036141", "FBgn0036141" ] }, "reaction_10468084": { "compartment": "compartment_20699", "id": "reaction_10468084", "reactome": "R-DME-3247844", "name": "WNT ligands traffic to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468028" ], "products": [ "species_10468058" ], "modifiers": [], "additional_components": [ "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141" ] }, "reaction_10468898": { "compartment": "compartment_876", "id": "reaction_10468898", "reactome": "R-DME-3781943", "name": "WLS:WNT complex is internalized for maturation into exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468058" ], "products": [ "species_10468866" ], "modifiers": [], "additional_components": [ "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141", "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902" ] }, "reaction_10468082": { "compartment": "compartment_984", "id": "reaction_10468082", "reactome": "R-DME-3247843", "name": "secretion of WNT ligands", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468058" ], "products": [ "species_10468080", "species_10468032" ], "modifiers": [], "additional_components": [ "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141", "P09615", "WG", "Q9VM25", "FBgn0031903", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "Q9VFX1", "FBgn0038134", "P40589", "FBgn0010453", "FBgn0036141" ] }, "reaction_10468896": { "compartment": "compartment_383505", "id": "reaction_10468896", "reactome": "R-DME-3781941", "name": "WNTs are secreted in exosomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468866" ], "products": [ "species_10468894" ], "modifiers": [], "additional_components": [ "Q95ST2", "FBgn0036141", "P28466", "FBgn0010194", "P09615", "WG", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28465", "FBgn0004360", "Q9VM26", "FBgn0031902", "P28466", "FBgn0010194", "P09615", "WG", "Q95ST2", "FBgn0036141" ] }, "reaction_10467936": { "compartment": "compartment_20699", "id": "reaction_10467936", "reactome": "R-DME-3247836", "name": "Retromer recycles WLS to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467930" ], "products": [ "species_10467934" ], "modifiers": [], "additional_components": [ "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q9VG51", "FBgn0038065", "Q95ST2", "FBgn0036141", "Q9W277", "FBgn0034708", "Q9VPX5", "FBgn0031310", "Q9W552", "FBgn0014411", "Q95ST2", "FBgn0036141", "Q9VG51", "FBgn0038065" ] }, "reaction_10444271": { "compartment": "compartment_70101", "id": "reaction_10444271", "reactome": "R-DME-354060", "name": "Translocation of RIAM to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444262", "species_10444267", "species_179856" ], "products": [ "species_10444269" ], "modifiers": [], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "FBgn0261811", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438" ] }, "reaction_10449918": { "compartment": "compartment_876", "id": "reaction_10449918", "reactome": "R-DME-443910", "name": "SHC1 dissociates from integrin alphaIIb beta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449914" ], "products": [ "species_10444292", "species_10431830" ], "modifiers": [], "additional_components": [ "Q9V3C8", "FBgn0015296", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "FBgn0015296" ] }, "reaction_10449916": { "compartment": "compartment_876", "id": "reaction_10449916", "reactome": "R-DME-443905", "name": "SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449253" ], "products": [ "species_10449914" ], "modifiers": [], "additional_components": [ "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296", "Q9V3C8", "FBgn0015296", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733" ] }, "reaction_10455337": { "compartment": "compartment_70101", "id": "reaction_10455337", "reactome": "R-DME-939265", "name": "Activation of Rap1 by membrane-associated GEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10444300" ], "products": [ "species_29420", "species_10444262" ], "modifiers": [ [ "species_10446030", "catalyst" ] ], "additional_components": [ "P08645", "FBgn0004636", "species_29420", "P08645", "FBgn0004636", "species_29438", "FBgn0085421" ] }, "reaction_10444296": { "compartment": "compartment_70101", "id": "reaction_10444296", "reactome": "R-DME-354097", "name": "Activation of Talin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444276", "species_10444269" ], "products": [ "species_10444278" ], "modifiers": [], "additional_components": [ "FBgn0260442", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442" ] }, "reaction_10449255": { "compartment": "compartment_70101", "id": "reaction_10449255", "reactome": "R-DME-432096", "name": "Activated integrin alphaIIb beta3 binds SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431840", "species_10444292" ], "products": [ "species_10449253" ], "modifiers": [], "additional_components": [ "FBgn0015296", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296" ] }, "reaction_10444294": { "compartment": "compartment_876", "id": "reaction_10444294", "reactome": "R-DME-354077", "name": "Integrin alphaIIb beta3 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444290", "species_10444278" ], "products": [ "species_10444292" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "species_179856", "Q9VWB7", "FBgn0261811", "P08645", "FBgn0004636", "species_29438", "Q9VSL8", "FBgn0260442", "P12080", "FBgn0001250", "Q8INJ8", "FBgn0262081", "P00528", "FBgn0262733" ] }, "reaction_10464527": { "compartment": "compartment_70101", "id": "reaction_10464527", "reactome": "R-DME-2032770", "name": "Translocation of YAP1 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544" ], "products": [ "species_10458548" ], "modifiers": [], "additional_components": [] }, "reaction_10464525": { "compartment": "compartment_70101", "id": "reaction_10464525", "reactome": "R-DME-2032768", "name": "Translocation of WWTR1 (TAZ) to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464315" ], "products": [ "species_10464523" ], "modifiers": [], "additional_components": [] }, "reaction_10464317": { "compartment": "compartment_70101", "id": "reaction_10464317", "reactome": "R-DME-2028661", "name": "Phosphorylation of WWTR1 (TAZ) by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10464315" ], "products": [ "species_10464309", "species_29370" ], "modifiers": [ [ "species_10464286", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464300": { "compartment": "compartment_70101", "id": "reaction_10464300", "reactome": "R-DME-2028626", "name": "Phosphorylated MOB1A proteins associate with LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464261", "species_10464269" ], "products": [ "species_10464271" ], "modifiers": [], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464298": { "compartment": "compartment_70101", "id": "reaction_10464298", "reactome": "R-DME-2028598", "name": "Phosphorylation of YAP by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544", "species_113592" ], "products": [ "species_29370", "species_10464295" ], "modifiers": [ [ "species_10464281", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464313": { "compartment": "compartment_70101", "id": "reaction_10464313", "reactome": "R-DME-2028651", "name": "YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432016", "species_10464309" ], "products": [ "species_10464311" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "Q45VV3", "yki", "P92177", "14-3-3epsilon" ] }, "reaction_10464568": { "compartment": "compartment_70101", "id": "reaction_10464568", "reactome": "R-DME-2038398", "name": "KIBRA (WWC1) binds LATS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464564", "species_10464261" ], "products": [ "species_10464566" ], "modifiers": [], "additional_components": [ "FBgn0262127", "Q9VA38", "WTS", "Q9VFG8", "FBgn0262127" ] }, "reaction_10464693": { "compartment": "compartment_70101", "id": "reaction_10464693", "reactome": "R-DME-2060328", "name": "Phosphorylation of WWTR1 (TAZ) by LATS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10464315" ], "products": [ "species_10464309", "species_29370" ], "modifiers": [ [ "species_10464281", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10464773": { "compartment": "compartment_70101", "id": "reaction_10464773", "reactome": "R-DME-2066299", "name": "DVL2 binds phosphorylated WWTR1 (TAZ)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441761", "species_10464309" ], "products": [ "species_10464771" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P51140", "phospho-dsh" ] }, "reaction_10464306": { "compartment": "compartment_70101", "id": "reaction_10464306", "reactome": "R-DME-2028644", "name": "YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432010", "species_10464284" ], "products": [ "species_10464304" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "Q45VV3", "yki", "P29310", "14-3-3zeta" ] }, "reaction_10464289": { "compartment": "compartment_70101", "id": "reaction_10464289", "reactome": "R-DME-2028583", "name": "Phosphorylation of YAP by LATS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458544", "species_113592" ], "products": [ "species_29370", "species_10464284" ], "modifiers": [ [ "species_10464286", "catalyst" ] ], "additional_components": [ "Q95RA8", "MATS", "Q9VA38", "WTS" ] }, "reaction_10440828": { "compartment": "compartment_70101", "id": "reaction_10440828", "reactome": "R-DME-198609", "name": "AKT phosphorylates TSC2, inhibiting it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10436925" ], "products": [ "species_29370", "species_10440825" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0005198", "FBgn0005198" ] }, "reaction_10441258": { "compartment": "compartment_70101", "id": "reaction_10441258", "reactome": "R-DME-200143", "name": "AKT phosphorylates AKT1S1 (PRAS40)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437061", "species_113592" ], "products": [ "species_29370", "species_10441256" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0267824", "FBgn0267824" ] }, "reaction_10493525": { "compartment": "compartment_70101", "id": "reaction_10493525", "reactome": "R-DME-8948757", "name": "AKT phosphorylates MKRN1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10456731" ], "products": [ "species_29370", "species_10493523" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0029152", "FBgn0029152" ] }, "reaction_10440837": { "compartment": "compartment_70101", "id": "reaction_10440837", "reactome": "R-DME-198611", "name": "AKT phosphorylates IKKalpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440832", "species_113592" ], "products": [ "species_10440835", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [] }, "reaction_10440852": { "compartment": "compartment_70101", "id": "reaction_10440852", "reactome": "R-DME-198621", "name": "AKT phosphorylates caspase-9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434854", "species_113592" ], "products": [ "species_10440850", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q8IRY7", "phospho-Dredd", "Q8IRY7", "phospho-Dredd", "Q9XYF4", "FBgn0026404" ] }, "reaction_10465457": { "compartment": "compartment_70101", "id": "reaction_10465457", "reactome": "R-DME-2219524", "name": "PDPK1 binds PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441880", "species_179856" ], "products": [ "species_10465455" ], "modifiers": [], "additional_components": [ "species_179856", "Q9W0V1", "Pdk1" ] }, "reaction_10441143": { "compartment": "compartment_876", "id": "reaction_10441143", "reactome": "R-DME-199443", "name": "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440860", "species_10440877" ], "products": [ "species_10440879" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "species_179838", "FBgn0028978", "Q9V3Z1", "FBgn0028978", "Q8INB9", "phospho-Akt1", "species_179838" ] }, "reaction_10441141": { "compartment": "compartment_70101", "id": "reaction_10441141", "reactome": "R-DME-199425", "name": "PHLPP dephosphorylates S473 in AKT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10440775" ], "products": [ "species_29372", "species_10441125" ], "modifiers": [ [ "species_10441138", "catalyst" ] ], "additional_components": [ "Q0E8W8", "FBgn0035008", "species_266099" ] }, "reaction_10489428": { "compartment": "compartment_70101", "id": "reaction_10489428", "reactome": "R-DME-8857925", "name": "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10440527" ], "products": [ "species_29370", "species_10489416" ], "modifiers": [ [ "species_10489425", "catalyst" ], [ "species_1806240", "catalyst" ] ], "additional_components": [] }, "reaction_10465529": { "compartment": "compartment_70101", "id": "reaction_10465529", "reactome": "R-DME-2316434", "name": "PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10465526", "catalyst" ] ], "additional_components": [ "Q9VLL4", "FBgn0032042", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q08012", "FBgn0004638", "Q9VZZ9", "FBgn0016794", "Q7KTZ2", "FBgn0020622", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "P91634", "Pi3K92E", "Q9XTN2", "chico", "P00528", "FBgn0262733", "D3DML3", "FBgn0044323", "Q8WS79", "FBgn0035849", "species_374146", "Q9NHV9", "FBgn0040068", "species_179838", "Q9VFI0", "FBgn0020299", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752" ] }, "reaction_10487135": { "compartment": "compartment_70101", "id": "reaction_10487135", "reactome": "R-DME-6811504", "name": "AKT1 dephosphorylation by PP2A-B56-beta,gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10440775" ], "products": [ "species_29372", "species_10446639" ], "modifiers": [ [ "species_10487126", "catalyst" ], [ "species_1806240", "inhibitor" ] ], "additional_components": [ "Q8IN89", "FBgn0042693", "Q9VXB7", "FBgn0052568" ] }, "reaction_10493536": { "compartment": "compartment_70101", "id": "reaction_10493536", "reactome": "R-DME-8948832", "name": "RNF146 polyubiquitinates PARylated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493530", "species_10426987" ], "products": [ "species_10488409" ], "modifiers": [ [ "species_10468669", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0036897" ] }, "reaction_10488401": { "compartment": "compartment_70101", "id": "reaction_10488401", "reactome": "R-DME-8850945", "name": "Casein kinase II phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10441147" ], "products": [ "species_10488399", "species_29370" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10486309": { "compartment": "compartment_70101", "id": "reaction_10486309", "reactome": "R-DME-6807206", "name": "USP13 and OTUD3 deubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10486306" ], "products": [ "species_10426987", "species_10441147" ], "modifiers": [ [ "species_10479271", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0035402" ] }, "reaction_10487829": { "compartment": "compartment_70101", "id": "reaction_10487829", "reactome": "R-DME-8847968", "name": "PTEN binds FRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441147", "species_10487825" ], "products": [ "species_10487827" ], "modifiers": [], "additional_components": [ "Q9V9J3", "phospho-Src42A", "Q7KMQ6", "Pten" ] }, "reaction_10493528": { "compartment": "compartment_70101", "id": "reaction_10493528", "reactome": "R-DME-8948775", "name": "MKRN1 polyubiquitinates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10441147" ], "products": [ "species_10486306" ], "modifiers": [ [ "species_10493523", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0029152" ] }, "reaction_10487835": { "compartment": "compartment_70101", "id": "reaction_10487835", "reactome": "R-DME-8847977", "name": "FRK phosphorylates PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487827" ], "products": [ "species_29370", "species_10487832", "species_10487825" ], "modifiers": [ [ "species_10487827", "catalyst" ] ], "additional_components": [ "Q9V9J3", "phospho-Src42A", "Q7KMQ6", "Pten", "Q9V9J3", "phospho-Src42A", "Q7KMQ6", "Pten" ] }, "reaction_10493533": { "compartment": "compartment_70101", "id": "reaction_10493533", "reactome": "R-DME-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441147", "species_29360" ], "products": [ "species_197277", "species_10493530" ], "modifiers": [ [ "species_10468679", "catalyst" ] ], "additional_components": [ "FBgn0027508" ] }, "reaction_10488413": { "compartment": "compartment_70101", "id": "reaction_10488413", "reactome": "R-DME-8850992", "name": "Proteasome degrades polyubiquitinated PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488411" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q7KMQ6", "Pten", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10486303": { "compartment": "compartment_70101", "id": "reaction_10486303", "reactome": "R-DME-6807134", "name": "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10441147" ], "products": [ "species_10486296" ], "modifiers": [ [ "species_10486300", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XYW6", "FBgn0027052", "Q9Y0H4", "FBgn0003557", "Q9VVI3", "FBgn0259174", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10441198": { "compartment": "compartment_7660", "id": "reaction_10441198", "reactome": "R-DME-199839", "name": "AKT can phosphorylate RSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441192" ], "products": [ "species_113582", "species_10441196" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0283472", "FBgn0283472" ] }, "reaction_10441208": { "compartment": "compartment_7660", "id": "reaction_10441208", "reactome": "R-DME-199863", "name": "AKT can phosphorylate NR4A1 (NUR77)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441203" ], "products": [ "species_113582", "species_10441206" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0014859", "FBgn0014859" ] }, "reaction_10441123": { "compartment": "compartment_7660", "id": "reaction_10441123", "reactome": "R-DME-199299", "name": "AKT phosphorylates FOXO transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441097" ], "products": [ "species_113582", "species_10441108" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10434463": { "compartment": "compartment_876", "id": "reaction_10434463", "reactome": "R-DME-111970", "name": "PKC phosphorylates GRK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10434429" ], "products": [ "species_29370", "species_10434460" ], "modifiers": [ [ "species_10434454", "catalyst" ] ], "additional_components": [ "FBgn0260798", "FBgn0260798", "species_74016", "P83099", "FBgn0259680", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10434389": { "compartment": "compartment_876", "id": "reaction_10434389", "reactome": "R-DME-111930", "name": "Adenylate cyclase produces cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10434384", "catalyst" ], [ "species_10434387", "catalyst" ] ], "additional_components": [ "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10434456": { "compartment": "compartment_70101", "id": "reaction_10434456", "reactome": "R-DME-111966", "name": "GRK2 binds CALM1:4Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10434429" ], "products": [ "species_10434431" ], "modifiers": [ [ "species_10434454", "inhibitor" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "FBgn0260798", "P32865", "FBgn0260798", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_74016", "P83099", "FBgn0259680", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10434412": { "compartment": "compartment_70101", "id": "reaction_10434412", "reactome": "R-DME-111956", "name": "Calmodulin activates Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434407" ], "products": [ "species_10434407" ], "modifiers": [ [ "species_10434387", "catalyst" ] ], "additional_components": [ "B7YZV4", "FBgn0264815", "B7YZV4", "FBgn0264815", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10434410": { "compartment": "compartment_70101", "id": "reaction_10434410", "reactome": "R-DME-111955", "name": "cAMP hydrolysis by Cam-PDE 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10434407", "catalyst" ] ], "additional_components": [ "B7YZV4", "FBgn0264815" ] }, "reaction_10440803": { "compartment": "compartment_876", "id": "reaction_10440803", "reactome": "R-DME-198314", "name": "DAG stimulates protein kinase C-delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440788", "species_113592" ], "products": [ "species_10440800", "species_29370" ], "modifiers": [ [ "species_10440788", "catalyst" ], [ "species_112275", "catalyst" ] ], "additional_components": [ "P83099", "FBgn0259680", "P13678", "FBgn0003093", "P13678", "FBgn0003093", "P83099", "FBgn0259680", "P83099", "FBgn0259680", "P13678", "FBgn0003093" ] }, "reaction_10497028": { "compartment": "compartment_876", "id": "reaction_10497028", "reactome": "R-DME-9029150", "name": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497022", "species_10497024" ], "products": [ "species_10497026" ], "modifiers": [], "additional_components": [ "Q9XYM0", "FBgn0024811", "O77086", "FBgn0259228", "Q9XTN2", "chico", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "Q9NHV9", "FBgn0040068", "Q08012", "FBgn0004638", "Q9NHV9", "FBgn0040068", "Q9XYM0", "FBgn0024811", "O77086", "FBgn0259228", "Q9XTN2", "chico", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "Q9V3C8", "FBgn0015296" ] }, "reaction_10496920": { "compartment": "compartment_876", "id": "reaction_10496920", "reactome": "R-DME-9021627", "name": "EPOR-associated PI3K phosphorylates PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10496917", "catalyst" ] ], "additional_components": [ "Q9VZZ9", "FBgn0016794", "Q9XTN2", "chico", "Q24592", "phospho-hop", "P00528", "FBgn0262733", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10462046": { "compartment": "compartment_70101", "id": "reaction_10462046", "reactome": "R-DME-1912357", "name": "ITCH ubiquitinates DTX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462041", "species_10426987" ], "products": [ "species_10462043" ], "modifiers": [ [ "species_10462041", "catalyst" ] ], "additional_components": [ "Q9Y0H4", "FBgn0003557", "Q23985", "dx", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9Y0H4", "FBgn0003557", "Q23985", "dx", "Q9Y0H4", "FBgn0003557", "Q23985", "dx" ] }, "reaction_10462467": { "compartment": "compartment_70101", "id": "reaction_10462467", "reactome": "R-DME-1980125", "name": "ITCH binds DTX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462035", "species_10456470" ], "products": [ "species_10462041" ], "modifiers": [], "additional_components": [ "FBgn0003557", "Q9Y0H4", "FBgn0003557", "Q23985", "dx" ] }, "reaction_10462113": { "compartment": "compartment_70101", "id": "reaction_10462113", "reactome": "R-DME-1912382", "name": "Mature NOTCH heterodimer traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462097" ], "products": [ "species_10462106" ], "modifiers": [ [ "species_10462111", "inhibitor" ] ], "additional_components": [ "Q7KU08", "FBgn0051665", "Q7KU08", "FBgn0051665", "FBgn0029709" ] }, "reaction_10497378": { "compartment": "compartment_70101", "id": "reaction_10497378", "reactome": "R-DME-9604328", "name": "AKT1 phosphorylates NOTCH4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10497365" ], "products": [ "species_10497371", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0051665", "FBgn0051665" ] }, "reaction_10471742": { "compartment": "compartment_17957", "id": "reaction_10471742", "reactome": "R-DME-5358336", "name": "P4HB forms mixed disulphides with Hh precursors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471730", "species_10468383" ], "products": [ "species_10471740" ], "modifiers": [], "additional_components": [ "FBgn0286818", "P54399", "FBgn0286818", "Q02936", "hh" ] }, "reaction_10471950": { "compartment": "compartment_12045", "id": "reaction_10471950", "reactome": "R-DME-5362441", "name": "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471897", "species_10471918" ], "products": [ "species_10471920" ], "modifiers": [], "additional_components": [ "Q02936", "hh", "Q9VKC7", "FBgn0032398", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q02936", "hh", "Q9VKC7", "FBgn0032398" ] }, "reaction_10471948": { "compartment": "compartment_12045", "id": "reaction_10471948", "reactome": "R-DME-5362437", "name": "C-terminal Hh fragments are bound by lectins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471895", "species_10471753" ], "products": [ "species_10471897" ], "modifiers": [], "additional_components": [ "FBgn0032398", "Q02936", "hh", "Q9VKC7", "FBgn0032398" ] }, "reaction_10471932": { "compartment": "compartment_12045", "id": "reaction_10471932", "reactome": "R-DME-5362412", "name": "SYVN1 ubiquitinates Hh C-terminal fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471920", "species_10426987" ], "products": [ "species_10471929" ], "modifiers": [ [ "species_10471920", "catalyst" ] ], "additional_components": [ "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q02936", "hh", "Q9VKC7", "FBgn0032398", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q9VKC7", "FBgn0032398", "Q02936", "hh", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q02936", "hh", "Q9VKC7", "FBgn0032398" ] }, "reaction_10471961": { "compartment": "compartment_70101", "id": "reaction_10471961", "reactome": "R-DME-5362459", "name": "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_10471929" ], "products": [ "species_10471952", "species_1132287", "species_29370", "species_10471895", "species_10471918" ], "modifiers": [ [ "species_10471929", "catalyst" ] ], "additional_components": [ "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q9VKC7", "FBgn0032398", "Q02936", "hh", "FBgn0032398", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q7KN62", "FBgn0286784", "Q9VEU2", "FBgn0038438", "Q9V415", "FBgn0028475", "Q95SP2", "FBgn0039875", "Q9VKC7", "FBgn0032398", "Q02936", "hh" ] }, "reaction_10471975": { "compartment": "compartment_876", "id": "reaction_10471975", "reactome": "R-DME-5362549", "name": "Hh-Np traffics to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471763" ], "products": [ "species_10471934" ], "modifiers": [], "additional_components": [] }, "reaction_10471958": { "compartment": "compartment_70101", "id": "reaction_10471958", "reactome": "R-DME-5362448", "name": "Hh C-terminal fragments are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471952" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10471890": { "compartment": "compartment_17957", "id": "reaction_10471890", "reactome": "R-DME-5362386", "name": "Glycosylation of Hh", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471884" ], "products": [ "species_10471730" ], "modifiers": [], "additional_components": [] }, "reaction_10471999": { "compartment": "compartment_876", "id": "reaction_10471999", "reactome": "R-DME-5362553", "name": "NOTUM releases Hh-Np:GPC5 from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471944" ], "products": [ "species_10471991" ], "modifiers": [ [ "species_10471996", "catalyst" ] ], "additional_components": [ "Q02936", "hh", "Q24114", "dally", "Q24114", "dally", "Q02936", "hh", "FBgn0044028" ] }, "reaction_10471946": { "compartment": "compartment_876", "id": "reaction_10471946", "reactome": "R-DME-5362427", "name": "Hh-Np binds GPC5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471942", "species_10471934" ], "products": [ "species_10471944" ], "modifiers": [], "additional_components": [ "Q02936", "hh", "Q24114", "dally" ] }, "reaction_10471760": { "compartment": "compartment_17957", "id": "reaction_10471760", "reactome": "R-DME-5358340", "name": "Autoproteolytic cleavage of Hh precursors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471740", "species_174672" ], "products": [ "species_10471745", "species_10471753", "species_10468383" ], "modifiers": [ [ "species_10471740", "catalyst" ] ], "additional_components": [ "P54399", "FBgn0286818", "Q02936", "hh", "FBgn0286818", "P54399", "FBgn0286818", "Q02936", "hh" ] }, "reaction_10471776": { "compartment": "compartment_17957", "id": "reaction_10471776", "reactome": "R-DME-5358343", "name": "HHAT palmitoylates Hh N-terminal fragment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471745", "species_5358339" ], "products": [ "species_10471763", "species_162743" ], "modifiers": [ [ "species_10471773", "catalyst" ] ], "additional_components": [] }, "reaction_10473197": { "compartment": "compartment_5263228", "id": "reaction_10473197", "reactome": "R-DME-5610767", "name": "The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472996" ], "products": [ "species_10473138" ], "modifiers": [ [ "species_10473149", "catalyst" ], [ "species_10473166", "catalyst" ], [ "species_10473195", "catalyst" ] ], "additional_components": [ "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "FBgn0030395", "Q9VPH0", "in", "O16868", "fuz", "Q7KRS6", "FBgn0016919", "Q9VRK9", "FBgn0004380", "Q9W040", "FBgn0035317", "Q9VQS5", "FBgn0031550", "Q9VMC0", "FBgn0031829" ] }, "reaction_10473035": { "compartment": "compartment_18730", "id": "reaction_10473035", "reactome": "R-DME-5610726", "name": "The IFT-A complex recruits TULP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473031", "species_10473003" ], "products": [ "species_10473033" ], "modifiers": [], "additional_components": [ "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264", "FBgn0015721", "Q86PC9", "FBgn0015721", "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264" ] }, "reaction_10473099": { "compartment": "compartment_5263232", "id": "reaction_10473099", "reactome": "R-DME-5610749", "name": "cAMP dissociates PKA, promoting GLI processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473095", "species_30389" ], "products": [ "species_10473097", "species_10472975" ], "modifiers": [], "additional_components": [ "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P16905", "FBgn0259243", "P81900", "FBgn0022382", "species_30389", "P16905", "FBgn0259243", "P81900", "FBgn0022382", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10473127": { "compartment": "compartment_24337", "id": "reaction_10473127", "reactome": "R-DME-5610763", "name": "PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473117" ], "products": [ "species_10473121" ], "modifiers": [ [ "species_10473125", "inhibitor" ] ], "additional_components": [ "P91682", "phospho-smo", "P91682", "phospho-smo" ] }, "reaction_10472998": { "compartment": "compartment_70101", "id": "reaction_10472998", "reactome": "R-DME-5610723", "name": "GLI proteins bind SUFU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472994", "species_10472988" ], "products": [ "species_10472996" ], "modifiers": [], "additional_components": [ "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355" ] }, "reaction_10473083": { "compartment": "compartment_70101", "id": "reaction_10473083", "reactome": "R-DME-5610746", "name": "SCF(beta-TrCP) ubiquitinates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473046", "species_10426987" ], "products": [ "species_10473081" ], "modifiers": [ [ "species_10442677", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q24311", "Cul1", "O77430", "SkpA", "Q9W5E1", "Roc1a" ] }, "reaction_10472986": { "compartment": "compartment_70101", "id": "reaction_10472986", "reactome": "R-DME-5610722", "name": "CK1 phosphorylates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472965", "species_113592" ], "products": [ "species_29370", "species_10472983" ], "modifiers": [ [ "species_10440489", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q7JWT4", "FBgn0037325", "P54367", "CkIalpha", "Q9VYN5", "FBgn0030384", "Q9VJC2", "FBgn0032650" ] }, "reaction_10473048": { "compartment": "compartment_70101", "id": "reaction_10473048", "reactome": "R-DME-5610732", "name": "GSK3 phosphorylates p-GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10472983" ], "products": [ "species_29370", "species_10473046" ], "modifiers": [ [ "species_10440540", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "P83101", "FBgn0046332", "P18431", "sgg" ] }, "reaction_10473107": { "compartment": "compartment_70101", "id": "reaction_10473107", "reactome": "R-DME-5610754", "name": "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473081" ], "products": [ "species_10472994", "species_10473101" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0005355", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10472978": { "compartment": "compartment_5263232", "id": "reaction_10472978", "reactome": "R-DME-5610720", "name": "PKA phosphorylates GLI3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10472956" ], "products": [ "species_29370", "species_10472965" ], "modifiers": [ [ "species_10472975", "catalyst" ] ], "additional_components": [ "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VG38", "FBgn0005355", "P19538", "ci", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10473042": { "compartment": "compartment_876", "id": "reaction_10473042", "reactome": "R-DME-5610727", "name": "GPR161 promotes cAMP production in a G alpha(s)-dependent manner", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10473039", "catalyst" ] ], "additional_components": [ "species_29926" ] }, "reaction_10473105": { "compartment": "compartment_70101", "id": "reaction_10473105", "reactome": "R-DME-5610752", "name": "GLI3R translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473101" ], "products": [ "species_10473103" ], "modifiers": [], "additional_components": [] }, "reaction_10473168": { "compartment": "compartment_5263232", "id": "reaction_10473168", "reactome": "R-DME-5610766", "name": "The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473138" ], "products": [ "species_10473144" ], "modifiers": [ [ "species_10473149", "catalyst" ], [ "species_10473156", "catalyst" ], [ "species_10473166", "catalyst" ] ], "additional_components": [ "P19538", "ci", "Q9VG38", "FBgn0005355", "Q9VG38", "FBgn0005355", "P19538", "ci", "FBgn0030395", "Q0E8P6", "FBgn0023096", "Q9VSJ6", "FBgn0265102", "Q9VPH0", "in", "O16868", "fuz" ] }, "reaction_10474463": { "compartment": "compartment_5263228", "id": "reaction_10474463", "reactome": "R-DME-5635843", "name": "GLI translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474454" ], "products": [ "species_10474442" ], "modifiers": [], "additional_components": [] }, "reaction_10474461": { "compartment": "compartment_5263228", "id": "reaction_10474461", "reactome": "R-DME-5635842", "name": "ULK3 phosphorylates GLI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5632460", "species_10473130" ], "products": [ "species_5632457", "species_10474454" ], "modifiers": [ [ "species_10474435", "catalyst" ] ], "additional_components": [ "FBgn0037679" ] }, "reaction_10474491": { "compartment": "compartment_7660", "id": "reaction_10474491", "reactome": "R-DME-5635854", "name": "GLI2,3 are degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474489" ], "products": [ "species_10427430", "species_10474487" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10474521": { "compartment": "compartment_70101", "id": "reaction_10474521", "reactome": "R-DME-5635868", "name": "ub-GLI is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474512" ], "products": [ "species_10426987", "species_10473055" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10474519": { "compartment": "compartment_261122", "id": "reaction_10474519", "reactome": "R-DME-5635865", "name": "SMURF1/2 dissociates from ub-PTCH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474517" ], "products": [ "species_10474372", "species_10437960" ], "modifiers": [], "additional_components": [ "Q9V853", "FBgn0029006", "P18502", "ptc", "FBgn0029006" ] }, "reaction_10474515": { "compartment": "compartment_70101", "id": "reaction_10474515", "reactome": "R-DME-5635864", "name": "NUMB:ITCH ubiquitinates GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474506", "species_10426987" ], "products": [ "species_10474512" ], "modifiers": [ [ "species_10474506", "catalyst" ] ], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci" ] }, "reaction_10474363": { "compartment": "compartment_261122", "id": "reaction_10474363", "reactome": "R-DME-5632652", "name": "Hh-Npp binds CDON and PTCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474355", "species_10473125", "species_10444875" ], "products": [ "species_10474361" ], "modifiers": [], "additional_components": [ "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "P18502", "ptc", "Q02936", "hh" ] }, "reaction_10474508": { "compartment": "compartment_70101", "id": "reaction_10474508", "reactome": "R-DME-5635861", "name": "NUMB:ITCH binds GLI1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472988", "species_10473055" ], "products": [ "species_10474506" ], "modifiers": [], "additional_components": [ "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P16554", "FBgn0002973", "Q9Y0H4", "FBgn0003557", "P19538", "ci" ] }, "reaction_10474376": { "compartment": "compartment_261122", "id": "reaction_10474376", "reactome": "R-DME-5632677", "name": "PTCH is internalized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474372" ], "products": [ "species_10474374" ], "modifiers": [], "additional_components": [] }, "reaction_10474504": { "compartment": "compartment_7660", "id": "reaction_10474504", "reactome": "R-DME-5635856", "name": "SPOP:CUL3:RBX1 ubiquitinates GLI2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10474493" ], "products": [ "species_10474489" ], "modifiers": [ [ "species_10474493", "catalyst" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci" ] }, "reaction_10474439": { "compartment": "compartment_18730", "id": "reaction_10474439", "reactome": "R-DME-5635839", "name": "ULK3:SUFU dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474437" ], "products": [ "species_10473136", "species_10474435" ], "modifiers": [], "additional_components": [ "Q9VHF6", "FBgn0037679", "Q9VG38", "FBgn0005355", "FBgn0005355", "FBgn0037679" ] }, "reaction_10474500": { "compartment": "compartment_7660", "id": "reaction_10474500", "reactome": "R-DME-5635855", "name": "phosphorylated GLI proteins bind SPOP:CUL3:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474450", "species_10474487" ], "products": [ "species_10474493" ], "modifiers": [ [ "species_10474498", "catalyst" ] ], "additional_components": [ "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q9VFP2", "rdx", "P19538", "ci", "FBgn0039201" ] }, "reaction_10474467": { "compartment": "compartment_7660", "id": "reaction_10474467", "reactome": "R-DME-5635845", "name": "GLI proteins bind CDC73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474448", "species_10434726" ], "products": [ "species_10474465" ], "modifiers": [], "additional_components": [ "FBgn0037657", "Q9VHI1", "FBgn0037657", "P19538", "ci" ] }, "reaction_10442699": { "compartment": "compartment_70101", "id": "reaction_10442699", "reactome": "R-DME-209536", "name": "IkB is ubiquitinated and degraded", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10437421" ], "products": [ "species_10442697" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q03017", "phospho-cact", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10440308": { "compartment": "compartment_13231", "id": "reaction_10440308", "reactome": "R-DME-193691", "name": "NF-kB migrates to the nucleus and turns on transcription", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10440364": { "compartment": "compartment_876", "id": "reaction_10440364", "reactome": "R-DME-193696", "name": "The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440360" ], "products": [ "species_10434904", "species_10440362" ], "modifiers": [], "additional_components": [ "Q9VW59", "RhoGDI", "P48148", "Rho1", "species_29420", "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476", "P48148", "Rho1", "species_29420", "Q9VW59", "RhoGDI", "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476" ] }, "reaction_10440455": { "compartment": "compartment_876", "id": "reaction_10440455", "reactome": "R-DME-194518", "name": "RhoA is activated by nucleotide exchange and inhibits axonal growth", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434904" ], "products": [ "species_10434906" ], "modifiers": [ [ "species_10440452", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "FBgn0050440" ] }, "reaction_10496236": { "compartment": "compartment_876", "id": "reaction_10496236", "reactome": "R-DME-9012761", "name": "The p75NTR:NgR:MDGI binds RHOA-GDI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440358", "species_10440314" ], "products": [ "species_10440360" ], "modifiers": [], "additional_components": [ "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476", "Q9VW59", "RhoGDI", "P48148", "Rho1", "species_29420", "Q9VW59", "RhoGDI", "P48148", "Rho1", "species_29420", "E1JHT6", "FBgn0053113", "Q9W266", "FBgn0034718", "P12024", "FBgn0267435", "Q9VZ84", "FBgn0035575", "Q9VS84", "FBgn0268063", "Q7KIN0", "FBgn0034476" ] }, "reaction_10444395": { "compartment": "compartment_984", "id": "reaction_10444395", "reactome": "R-DME-373075", "name": "Metabotropic glutamate receptors bind glutamate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10444389" ], "products": [ "species_10444393" ], "modifiers": [], "additional_components": [ "FBgn0019985", "P91685", "FBgn0019985", "species_210382" ] }, "reaction_10497512": { "compartment": "compartment_984", "id": "reaction_10497512", "reactome": "R-DME-9611839", "name": "3-agonists bind ADRB3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9611836", "species_10445401" ], "products": [ "species_10497510" ], "modifiers": [], "additional_components": [ "FBgn0039419", "Q9VBG4", "FBgn0039419" ] }, "reaction_10497514": { "compartment": "compartment_984", "id": "reaction_10497514", "reactome": "R-DME-9611852", "name": "ADRB3 bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10445401" ], "products": [ "species_10445403" ], "modifiers": [ [ "species_10497510", "catalyst" ], [ "species_10497386", "inhibitor" ] ], "additional_components": [ "CHEBI:28918", "species_351597", "FBgn0039419", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "Q9VBG4", "FBgn0039419", "Q9VBG4", "FBgn0039419" ] }, "reaction_10497388": { "compartment": "compartment_984", "id": "reaction_10497388", "reactome": "R-DME-9609310", "name": "-blockers bind ADRB1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9609307", "species_10445401" ], "products": [ "species_10497386" ], "modifiers": [], "additional_components": [ "FBgn0039419", "Q9VBG4", "FBgn0039419" ] }, "reaction_10446674": { "compartment": "compartment_984", "id": "reaction_10446674", "reactome": "R-DME-390663", "name": "ADRA2A,B,C bind ADR,NAd", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10445692" ], "products": [ "species_10445696" ], "modifiers": [], "additional_components": [ "CHEBI:28918", "species_351597", "FBgn0004514", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10446680": { "compartment": "compartment_984", "id": "reaction_10446680", "reactome": "R-DME-390846", "name": "D2D3,4 bind to DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380873", "species_10445685" ], "products": [ "species_10445687" ], "modifiers": [], "additional_components": [ "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873" ] }, "reaction_10446678": { "compartment": "compartment_984", "id": "reaction_10446678", "reactome": "R-DME-390835", "name": "DRD1,5 bind DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445408", "species_380873" ], "products": [ "species_10445412" ], "modifiers": [], "additional_components": [ "FBgn0038063", "species_380873", "Q4LBB9", "FBgn0038063" ] }, "reaction_10498330": { "compartment": "compartment_984", "id": "reaction_10498330", "reactome": "R-DME-9656244", "name": "DRD2 binds DA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_380873", "species_10498326" ], "products": [ "species_10498328" ], "modifiers": [], "additional_components": [ "FBgn0053517", "Q8IS44", "FBgn0053517", "species_380873" ] }, "reaction_10446686": { "compartment": "compartment_984", "id": "reaction_10446686", "reactome": "R-DME-390931", "name": "5-HT4, 6 and 7 receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445424", "species_114523" ], "products": [ "species_10445426" ], "modifiers": [], "additional_components": [ "P20905", "FBgn0004573", "P41596", "FBgn0011582", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582" ] }, "reaction_10446684": { "compartment": "compartment_984", "id": "reaction_10446684", "reactome": "R-DME-390929", "name": "HTR1 and 5A receptors can bind serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445666", "species_114523" ], "products": [ "species_10445668" ], "modifiers": [], "additional_components": [ "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_114523", "P28285", "FBgn0004168", "P28286", "FBgn0263116" ] }, "reaction_10498659": { "compartment": "compartment_984", "id": "reaction_10498659", "reactome": "R-DME-9693347", "name": "HTR1A binds 5HT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498655", "species_114523" ], "products": [ "species_10498657" ], "modifiers": [], "additional_components": [ "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_114523", "P28285", "FBgn0004168", "P28286", "FBgn0263116" ] }, "reaction_10446676": { "compartment": "compartment_984", "id": "reaction_10446676", "reactome": "R-DME-390673", "name": "CHRM2,4 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445698", "species_372533" ], "products": [ "species_10445702" ], "modifiers": [], "additional_components": [ "FBgn0000037", "species_372533", "P16395", "FBgn0000037" ] }, "reaction_10446672": { "compartment": "compartment_984", "id": "reaction_10446672", "reactome": "R-DME-390649", "name": "CHRM1,3,5 bind acetylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445550", "species_372533" ], "products": [ "species_10445556" ], "modifiers": [], "additional_components": [ "FBgn0000037", "species_372533", "P16395", "FBgn0000037" ] }, "reaction_10446688": { "compartment": "compartment_984", "id": "reaction_10446688", "reactome": "R-DME-391211", "name": "Trace amine-associated receptors can bind trace amines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445431", "species_391200" ], "products": [ "species_10445445" ], "modifiers": [], "additional_components": [ "FBgn0029909", "species_391200", "Q9W3V5", "FBgn0029909" ] }, "reaction_10447672": { "compartment": "compartment_984", "id": "reaction_10447672", "reactome": "R-DME-419861", "name": "Melanospin is stimulated by light", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419777", "species_10445561" ], "products": [ "species_10445563" ], "modifiers": [], "additional_components": [ "FBgn0019940", "O01668", "FBgn0019940", "species_419777" ] }, "reaction_10446747": { "compartment": "compartment_984", "id": "reaction_10446747", "reactome": "R-DME-391375", "name": "Thyroid-stimulating hormone receptor can bind TSH, Thyrostimulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445459", "species_10445450" ], "products": [ "species_10445461" ], "modifiers": [], "additional_components": [ "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "FBgn0016650", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368" ] }, "reaction_10447588": { "compartment": "compartment_984", "id": "reaction_10447588", "reactome": "R-DME-418925", "name": "ADORA2A,B bind Ade-Rib", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83908", "species_10445466" ], "products": [ "species_10445470" ], "modifiers": [], "additional_components": [ "FBgn0039747", "species_83908", "Q9VAA2", "FBgn0039747" ] }, "reaction_10447586": { "compartment": "compartment_984", "id": "reaction_10447586", "reactome": "R-DME-418904", "name": "A1 and A3 receptors bind adenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445704", "species_83908" ], "products": [ "species_10445708" ], "modifiers": [], "additional_components": [ "FBgn0039747", "species_83908", "Q9VAA2", "FBgn0039747" ] }, "reaction_10450073": { "compartment": "compartment_984", "id": "reaction_10450073", "reactome": "R-DME-444654", "name": "G-protein coupled bile acid receptor binds lithocholic acid", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_444840", "species_10445494" ], "products": [ "species_10445496" ], "modifiers": [], "additional_components": [ "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "FBgn0039747", "Q9VAA2", "FBgn0039747", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755" ] }, "reaction_10446753": { "compartment": "compartment_984", "id": "reaction_10446753", "reactome": "R-DME-391934", "name": "DP2 receptor can bind PGD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_416911", "species_10445718" ], "products": [ "species_10445720" ], "modifiers": [], "additional_components": [ "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429" ] }, "reaction_10498546": { "compartment": "compartment_984", "id": "reaction_10498546", "reactome": "R-DME-9690439", "name": "CYSLTR1 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445565", "species_416372" ], "products": [ "species_10445567" ], "modifiers": [ [ "species_10498535", "inhibitor" ] ], "additional_components": [ "FBgn0039595", "species_266074", "species_266013", "species_266033", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "Q9NBC8", "FBgn0039595" ] }, "reaction_10498537": { "compartment": "compartment_984", "id": "reaction_10498537", "reactome": "R-DME-9684627", "name": "CYSLTR1 binds CYSLTR1 antagonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9684615", "species_10445565" ], "products": [ "species_10498535" ], "modifiers": [], "additional_components": [ "FBgn0039595", "Q9NBC8", "FBgn0039595" ] }, "reaction_10446757": { "compartment": "compartment_984", "id": "reaction_10446757", "reactome": "R-DME-391943", "name": "CYSLT2 binds LTC4,LTD4,LTE4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445569", "species_416372" ], "products": [ "species_10445571" ], "modifiers": [], "additional_components": [ "FBgn0039595", "species_266074", "species_266013", "species_266033", "species_266074", "species_266013", "species_266033", "Q9NBC8", "FBgn0039595" ] }, "reaction_10446755": { "compartment": "compartment_984", "id": "reaction_10446755", "reactome": "R-DME-391941", "name": "BLT receptors can bind LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445573", "species_416436" ], "products": [ "species_10445577" ], "modifiers": [], "additional_components": [ "FBgn0039595", "species_416436", "Q9NBC8", "FBgn0039595" ] }, "reaction_10447656": { "compartment": "compartment_984", "id": "reaction_10447656", "reactome": "R-DME-419334", "name": "Melatonin receptors can bind melatonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419339", "species_10445738" ], "products": [ "species_10445740" ], "modifiers": [], "additional_components": [ "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339" ] }, "reaction_10450092": { "compartment": "compartment_984", "id": "reaction_10450092", "reactome": "R-DME-444879", "name": "Relaxin receptor 2 binds relaxin 2 and INSL3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445490", "species_10445482" ], "products": [ "species_10445492" ], "modifiers": [], "additional_components": [ "Q9VT53", "ILP4 alpha chain", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain" ] }, "reaction_10497587": { "compartment": "compartment_984", "id": "reaction_10497587", "reactome": "R-DME-9615249", "name": "ARBs bind AGRT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9615246", "species_10444647" ], "products": [ "species_10444713" ], "modifiers": [], "additional_components": [ "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632" ] }, "reaction_10444715": { "compartment": "compartment_984", "id": "reaction_10444715", "reactome": "R-DME-374173", "name": "AGT(34-41) binds to AGTR1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444709", "species_10444647" ], "products": [ "species_10444711" ], "modifiers": [ [ "species_10444713", "inhibitor" ] ], "additional_components": [ "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632" ] }, "reaction_10497589": { "compartment": "compartment_984", "id": "reaction_10497589", "reactome": "R-DME-9615348", "name": "AGT(34-41) binds to AGTR2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445652", "species_10444709" ], "products": [ "species_10445654" ], "modifiers": [], "additional_components": [ "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9W533", "FBgn0025632" ] }, "reaction_10481289": { "compartment": "compartment_876", "id": "reaction_10481289", "reactome": "R-DME-6797630", "name": "LRPP4(LRPP1-3,5) hydrolyse LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_417891" ], "products": [ "species_109277", "species_6797635" ], "modifiers": [ [ "species_10481286", "catalyst" ] ], "additional_components": [ "FBgn0037341" ] }, "reaction_10454110": { "compartment": "compartment_876", "id": "reaction_10454110", "reactome": "R-DME-749456", "name": "Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445744", "species_10445742" ], "products": [ "species_10445746" ], "modifiers": [], "additional_components": [ "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10437323": { "compartment": "compartment_947587", "id": "reaction_10437323", "reactome": "R-DME-167433", "name": "G-protein beta-gamma subunits rebind the alpha-GDP subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10434469" ], "products": [ "species_10437302" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10437321": { "compartment": "compartment_70101", "id": "reaction_10437321", "reactome": "R-DME-167429", "name": "The receptor:G-protein complex binds GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10437316" ], "products": [ "species_10434583" ], "modifiers": [ [ "species_10434215", "catalyst" ] ], "additional_components": [ "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054" ] }, "reaction_10437318": { "compartment": "compartment_70101", "id": "reaction_10437318", "reactome": "R-DME-167419", "name": "The receptor:G-protein complex releases GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437304" ], "products": [ "species_29420", "species_10437316" ], "modifiers": [], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P38040", "FBgn0004921", "P26308", "FBgn0001105" ] }, "reaction_10437300": { "compartment": "compartment_947587", "id": "reaction_10437300", "reactome": "R-DME-167415", "name": "G-protein alpha subunit is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10434217" ], "products": [ "species_29438", "species_10434469" ], "modifiers": [ [ "species_10434215", "catalyst" ] ], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054" ] }, "reaction_10498096": { "compartment": "compartment_70101", "id": "reaction_10498096", "reactome": "R-DME-9644869", "name": "p-S54-PDE4B hydrolyses cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10438771", "catalyst" ] ], "additional_components": [ "FBgn0000479" ] }, "reaction_10434424": { "compartment": "compartment_70101", "id": "reaction_10434424", "reactome": "R-DME-111962", "name": "PDE4A,C,D hydrolyse cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10434417", "catalyst" ] ], "additional_components": [ "FBgn0000479" ] }, "reaction_10438774": { "compartment": "compartment_70101", "id": "reaction_10438774", "reactome": "R-DME-177284", "name": "PKA phosphorylates PDE4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438768", "species_113592" ], "products": [ "species_10438771", "species_29370" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "FBgn0000479", "FBgn0000479", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10437758": { "compartment": "compartment_876", "id": "reaction_10437758", "reactome": "R-DME-170666", "name": "Adenylate cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437751" ], "products": [ "species_29372", "species_10437755" ], "modifiers": [ [ "species_10437751", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "P20353", "FBgn0001104", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437771": { "compartment": "compartment_876", "id": "reaction_10437771", "reactome": "R-DME-170674", "name": "Dissociation of the Gi alpha:G olf complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437769" ], "products": [ "species_10434384", "species_10437767", "species_10437753" ], "modifiers": [], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "species_29420", "P20353", "FBgn0001104", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420" ] }, "reaction_10437783": { "compartment": "compartment_876", "id": "reaction_10437783", "reactome": "R-DME-170686", "name": "Adenylate cyclase increases the GTPase activity of Gi alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437751" ], "products": [ "species_29372", "species_10437769" ], "modifiers": [ [ "species_10437751", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437760": { "compartment": "compartment_876", "id": "reaction_10437760", "reactome": "R-DME-170671", "name": "G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437749", "species_10437740" ], "products": [ "species_10437751" ], "modifiers": [], "additional_components": [ "P20353", "FBgn0001104", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "P20353", "FBgn0001104", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10434222": { "compartment": "compartment_70101", "id": "reaction_10434222", "reactome": "R-DME-111879", "name": "PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10434219", "catalyst" ] ], "additional_components": [ "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10434471": { "compartment": "compartment_70101", "id": "reaction_10434471", "reactome": "R-DME-112037", "name": "Inactivation of PLC beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10434219" ], "products": [ "species_29372", "species_10434469", "species_10434186" ], "modifiers": [], "additional_components": [ "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P25455", "FBgn0004611", "P13217", "FBgn0262738" ] }, "reaction_10437774": { "compartment": "compartment_876", "id": "reaction_10437774", "reactome": "R-DME-170676", "name": "Adenylate cyclase converts ATP into cyclic AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592" ], "products": [ "species_111294", "species_30389" ], "modifiers": [ [ "species_10437762", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437765": { "compartment": "compartment_876", "id": "reaction_10437765", "reactome": "R-DME-170672", "name": "Galpha-olf:GTP binds to adenylate cyclase and activates it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434384", "species_10437740" ], "products": [ "species_10437762" ], "modifiers": [ [ "species_10434384", "catalyst" ] ], "additional_components": [ "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437781": { "compartment": "compartment_876", "id": "reaction_10437781", "reactome": "R-DME-170685", "name": "Adenylaye cyclase increases the GTPase activity of G alpha-olf", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437762" ], "products": [ "species_10437776", "species_29372" ], "modifiers": [ [ "species_10437762", "catalyst" ] ], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29438", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926" ] }, "reaction_10437778": { "compartment": "compartment_876", "id": "reaction_10437778", "reactome": "R-DME-170677", "name": "The G alpha-olf:GDP:Adenylate cyclase complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437776" ], "products": [ "species_10434384", "species_10437753" ], "modifiers": [], "additional_components": [ "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q9V9R3", "FBgn0023416", "Q9VP76", "FBgn0024150", "Q9VW60", "FBgn0004852", "Q9VK50", "FBgn0040506", "Q9VK53", "FBgn0040508", "Q9W038", "FBgn0040507", "Q8IRF5", "FBgn0052305", "Q9VK52", "FBgn0040509", "Q9W037", "FBgn0052305", "A8JNU1", "FBgn0263131", "Q9VK51", "FBgn0040510", "P32870", "FBgn0003301", "M9PEP2", "FBgn0022710", "species_29926", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "species_29420" ] }, "reaction_10454108": { "compartment": "compartment_984", "id": "reaction_10454108", "reactome": "R-DME-749454", "name": "The Ligand:GPCR:Gi complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445750" ], "products": [ "species_10434579", "species_10437747", "species_10445742" ], "modifiers": [], "additional_components": [ "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "P20353", "FBgn0001104", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P20353", "FBgn0001104", "species_29438", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10495699": { "compartment": "compartment_876", "id": "reaction_10495699", "reactome": "R-DME-8982012", "name": "G alpha (i):RGS dissociates to inactive G alpha (i)i1/i2/i3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495697" ], "products": [ "species_10495695", "species_10437767" ], "modifiers": [], "additional_components": [ "species_29420", "P20353", "FBgn0001104", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "species_29420", "P20353", "FBgn0001104" ] }, "reaction_10495369": { "compartment": "compartment_876", "id": "reaction_10495369", "reactome": "R-DME-8964242", "name": "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10495361" ], "products": [ "species_29370", "species_10495366" ], "modifiers": [ [ "species_10495361", "catalyst" ] ], "additional_components": [ "P20353", "FBgn0001104", "species_29438", "P00528", "FBgn0262733", "P00528", "FBgn0262733", "P20353", "FBgn0001104", "species_29438", "P20353", "FBgn0001104", "species_29438", "P00528", "FBgn0262733" ] }, "reaction_10495371": { "compartment": "compartment_70101", "id": "reaction_10495371", "reactome": "R-DME-8964329", "name": "G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495366" ], "products": [ "species_10437747", "species_10495364" ], "modifiers": [], "additional_components": [ "P00528", "FBgn0262733", "P20353", "FBgn0001104", "species_29438", "P20353", "FBgn0001104", "species_29438", "FBgn0262733" ] }, "reaction_10495707": { "compartment": "compartment_876", "id": "reaction_10495707", "reactome": "R-DME-8982019", "name": "Active G alpha (i)i1/i2/i3 binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495695", "species_10437747" ], "products": [ "species_10495705" ], "modifiers": [], "additional_components": [ "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "P20353", "FBgn0001104", "species_29438", "P20353", "FBgn0001104", "species_29438", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927" ] }, "reaction_10454114": { "compartment": "compartment_876", "id": "reaction_10454114", "reactome": "R-DME-751001", "name": "Inactive G alpha (i) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10437767" ], "products": [ "species_10445744" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P20353", "FBgn0001104", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10495710": { "compartment": "compartment_876", "id": "reaction_10495710", "reactome": "R-DME-8982020", "name": "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495705" ], "products": [ "species_29372", "species_10495697" ], "modifiers": [ [ "species_10495705", "catalyst" ] ], "additional_components": [ "P20353", "FBgn0001104", "species_29438", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "species_29420", "P20353", "FBgn0001104", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927", "P20353", "FBgn0001104", "species_29438", "Q8T017", "FBgn0028743", "Q9VXA3", "FBgn0024941", "Q9VCX1", "FBgn0020278", "M9PHI8", "FBgn0259927" ] }, "reaction_10445760": { "compartment": "compartment_947587", "id": "reaction_10445760", "reactome": "R-DME-380073", "name": "Liganded Gi-activating GPCR acts as a GEF for Gi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10445746" ], "products": [ "species_29420", "species_10445750" ], "modifiers": [ [ "species_10445746", "catalyst" ], [ "species_10445756", "inhibitor" ] ], "additional_components": [ "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "P20353", "FBgn0001104", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "species_419339", "P91685", "FBgn0019985", "species_210382", "species_390899", "P16395", "FBgn0000037", "species_416911", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "Q8IS44", "FBgn0053517", "P28285", "FBgn0004168", "P28286", "FBgn0263116", "species_380873", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "species_114523", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "FBgn0040080" ] }, "reaction_10454106": { "compartment": "compartment_70101", "id": "reaction_10454106", "reactome": "R-DME-749453", "name": "Liganded Gz-activating GPCR acts as a GEF for Gz", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10454097" ], "products": [ "species_29420", "species_10454103" ], "modifiers": [ [ "species_10454097", "catalyst" ] ], "additional_components": [ "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10447293": { "compartment": "compartment_876", "id": "reaction_10447293", "reactome": "R-DME-416516", "name": "GRK2 sequesters activated Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434217", "species_10434429" ], "products": [ "species_10447291" ], "modifiers": [], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "FBgn0260798", "P32865", "FBgn0260798", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10495715": { "compartment": "compartment_876", "id": "reaction_10495715", "reactome": "R-DME-8982025", "name": "G alpha (q) in G (q):RGS complex is inactivated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495701" ], "products": [ "species_29372", "species_10495712" ], "modifiers": [ [ "species_10495701", "catalyst" ] ], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q8T017", "FBgn0028743", "Q8T017", "FBgn0028743", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q8T017", "FBgn0028743" ] }, "reaction_10447579": { "compartment": "compartment_876", "id": "reaction_10447579", "reactome": "R-DME-418582", "name": "G alpha (q) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434217" ], "products": [ "species_10434979" ], "modifiers": [ [ "species_10434217", "catalyst" ], [ "species_10447577", "catalyst" ] ], "additional_components": [ "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "FBgn0028743" ] }, "reaction_10495717": { "compartment": "compartment_876", "id": "reaction_10495717", "reactome": "R-DME-8982026", "name": "G alpha (q):RGS dissociates to inactive G alpha (q)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495712" ], "products": [ "species_10434979", "species_10447577" ], "modifiers": [], "additional_components": [ "Q8T017", "FBgn0028743", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "FBgn0028743" ] }, "reaction_10445588": { "compartment": "compartment_70101", "id": "reaction_10445588", "reactome": "R-DME-379048", "name": "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10445581" ], "products": [ "species_29420", "species_10445583" ], "modifiers": [ [ "species_10445585", "catalyst" ] ], "additional_components": [ "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9NBC8", "FBgn0039595", "species_266013" ] }, "reaction_10447284": { "compartment": "compartment_70101", "id": "reaction_10447284", "reactome": "R-DME-400586", "name": "G alpha (q) binds to Trio family RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447280", "species_10434217" ], "products": [ "species_10447282" ], "modifiers": [], "additional_components": [ "FBgn0024277", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q7KVD1", "FBgn0024277" ] }, "reaction_10453966": { "compartment": "compartment_876", "id": "reaction_10453966", "reactome": "R-DME-749448", "name": "Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434981", "species_10445579" ], "products": [ "species_10445581" ], "modifiers": [], "additional_components": [ "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10454089": { "compartment": "compartment_984", "id": "reaction_10454089", "reactome": "R-DME-749452", "name": "The Ligand:GPCR:Gq complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445583" ], "products": [ "species_10454081", "species_10434579", "species_10454087", "species_10434217" ], "modifiers": [], "additional_components": [ "Q9NBC8", "FBgn0039595", "species_266074", "species_266013", "species_266033", "O01668", "FBgn0019940", "species_419777", "species_416436", "Q9NDM2", "FBgn0046687", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_372533", "P16395", "FBgn0000037", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "Q9VFW6", "FBgn0038139", "Q9VFW5", "FBgn0038140", "Q8ITC9", "FBgn0038201", "Q8ITC7", "FBgn0037100", "Q9NBC8", "FBgn0039595", "Q9VML9", "FBgn0085410", "O01668", "FBgn0019940", "Q8IN35", "FBgn0038880", "Q7KTL9", "FBgn0025595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "P16395", "FBgn0000037", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260", "Q4V622", "FBgn0033058", "A1ZAX0", "FBgn0050106", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_74016", "species_29370", "species_419777", "species_113592", "species_210382", "species_163953", "species_1562550", "species_114523", "species_2161759", "P14599", "FBgn0000108", "CHEBI:28716", "species_3632881", "CHEBI:28875", "CHEBI:53460", "CHEBI:27997", "CHEBI:16196", "species_9024011", "CHEBI:53487", "CHEBI:53486", "species_8934421", "CHEBI:53488", "CHEBI:28661", "CHEBI:28364", "CHEBI:27432", "species_29444", "species_29468", "species_113585", "species_417891", "CHEBI:28918", "species_351597", "species_205687", "CHEBI:52450", "species_29460", "CHEBI:31011", "CHEBI:30772", "species_29416", "CHEBI:30768", "CHEBI:50122", "species_33549", "CHEBI:42504", "species_372533", "species_266074", "species_266013", "species_266033", "species_416436", "CHEBI:17120", "species_209849", "species_390899", "CHEBI:15627", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "species_879535", "species_265287", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10495703": { "compartment": "compartment_876", "id": "reaction_10495703", "reactome": "R-DME-8982017", "name": "Active G alpha (q) binds RGS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447577", "species_10434217" ], "products": [ "species_10495701" ], "modifiers": [], "additional_components": [ "FBgn0028743", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "Q8T017", "FBgn0028743" ] }, "reaction_10465276": { "compartment": "compartment_70101", "id": "reaction_10465276", "reactome": "R-DME-2179407", "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10465273", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "P04412", "FBgn0003731", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10465281": { "compartment": "compartment_876", "id": "reaction_10465281", "reactome": "R-DME-2179413", "name": "Activated PKC-alpha activate MMP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465278" ], "products": [ "species_10459256" ], "modifiers": [ [ "species_10447182", "catalyst" ] ], "additional_components": [ "FBgn0035049", "FBgn0035049", "species_114519", "P05130", "FBgn0003091" ] }, "reaction_10447184": { "compartment": "compartment_876", "id": "reaction_10447184", "reactome": "R-DME-400015", "name": "Diacylgycerol activates Protein kinase C, alpha type", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434436", "species_114519" ], "products": [ "species_10447182" ], "modifiers": [], "additional_components": [ "FBgn0003091", "species_114519", "P05130", "FBgn0003091" ] }, "reaction_10454112": { "compartment": "compartment_876", "id": "reaction_10454112", "reactome": "R-DME-750993", "name": "Inactive G alpha (q) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10434979" ], "products": [ "species_10434981" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10435008": { "compartment": "compartment_876", "id": "reaction_10435008", "reactome": "R-DME-114688", "name": "PLC-beta hydrolyses PIP2 to DAG and IP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435003" ], "products": [ "species_10435005" ], "modifiers": [ [ "species_10434219", "catalyst" ] ], "additional_components": [ "species_179856", "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "species_114519", "species_114520", "P25455", "FBgn0004611", "P13217", "FBgn0262738", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10498738": { "compartment": "compartment_70101", "id": "reaction_10498738", "reactome": "R-DME-9708261", "name": "PDE4A hydrolyses cAMP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10434417", "catalyst" ] ], "additional_components": [ "FBgn0000479" ] }, "reaction_10445545": { "compartment": "compartment_70101", "id": "reaction_10445545", "reactome": "R-DME-379044", "name": "Liganded Gs-activating GPCR acts as a GEF for Gs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445536", "species_29438" ], "products": [ "species_29420", "species_10445542" ], "modifiers": [ [ "species_10445536", "catalyst" ] ], "additional_components": [ "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "species_391200", "Q9W3V5", "FBgn0029909", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "species_380873", "Q4LBB9", "FBgn0038063", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain", "Q9NBC8", "FBgn0039595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q7KTL9", "FBgn0025595", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582", "species_83908", "Q9VAA2", "FBgn0039747", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "species_391200", "Q9W3V5", "FBgn0029909", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "species_380873", "Q4LBB9", "FBgn0038063", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain", "Q9NBC8", "FBgn0039595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q7KTL9", "FBgn0025595", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29438", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_83908", "Q9VAA2", "FBgn0039747", "CHEBI:28918", "species_351597", "Q9VBG4", "FBgn0039419", "CHEBI:28834", "species_193473", "species_176655", "CHEBI:16755", "species_391200", "Q9W3V5", "FBgn0029909", "Q9VEG4", "FBgn0016650", "A0A6I8WFJ4", "FBgn0261386", "Q4V4C8", "FBgn0063368", "species_380873", "Q4LBB9", "FBgn0038063", "X2JJX6", "FBgn0085440", "Q9VBP0", "FBgn0039354", "Q9VT53", "ILP4 alpha chain", "Q9NBC8", "FBgn0039595", "Q9W534", "FBgn0025631", "Q9W533", "FBgn0025632", "Q9NDM2", "FBgn0046687", "Q7KTL9", "FBgn0025595", "species_114523", "P20905", "FBgn0004573", "P41596", "FBgn0011582" ] }, "reaction_10447560": { "compartment": "compartment_70101", "id": "reaction_10447560", "reactome": "R-DME-418553", "name": "cAMP degradation by Phosphodiesterases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_30389" ], "products": [ "species_76577" ], "modifiers": [ [ "species_10447557", "catalyst" ] ], "additional_components": [ "B7YZV4", "FBgn0264815", "Q9VFI9", "FBgn0038237", "Q9VJ79", "FBgn0085370", "Q6NNF2", "FBgn0266377", "Q9W4T4", "FBgn0000479" ] }, "reaction_10446862": { "compartment": "compartment_876", "id": "reaction_10446862", "reactome": "R-DME-398185", "name": "LARG binds plexin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444613", "species_10446856" ], "products": [ "species_10446860" ], "modifiers": [], "additional_components": [ "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740", "P25157", "FBgn0000384", "species_29438", "A1ZAN6", "FBgn0023172", "P25157", "FBgn0000384", "species_29438", "A1ZAN6", "FBgn0023172", "Q9V491", "FBgn0025741", "Q9V4A7", "FBgn0025740" ] }, "reaction_10434925": { "compartment": "compartment_70101", "id": "reaction_10434925", "reactome": "R-DME-114548", "name": "G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434913", "species_10434918" ], "products": [ "species_10434920" ], "modifiers": [], "additional_components": [ "P25157", "FBgn0000384", "species_29438", "FBgn0023172", "A1ZAN6", "FBgn0023172", "P25157", "FBgn0000384", "species_29438" ] }, "reaction_10447565": { "compartment": "compartment_876", "id": "reaction_10447565", "reactome": "R-DME-418574", "name": "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446850" ], "products": [ "species_10447562" ], "modifiers": [ [ "species_10446850", "catalyst" ] ], "additional_components": [ "P25157", "FBgn0000384", "species_29438", "P25157", "FBgn0000384", "species_29420", "P25157", "FBgn0000384", "species_29438" ] }, "reaction_10454125": { "compartment": "compartment_876", "id": "reaction_10454125", "reactome": "R-DME-751039", "name": "Inactive G alpha (12/13) reassociates with G beta:gamma", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434579", "species_10447562" ], "products": [ "species_10434939" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P25157", "FBgn0000384", "species_29420", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10454123": { "compartment": "compartment_70101", "id": "reaction_10454123", "reactome": "R-DME-751029", "name": "Liganded G12/13-activating GPCR acts as a GEF for G12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10454120" ], "products": [ "species_29420", "species_10454118" ], "modifiers": [ [ "species_10454120", "catalyst" ] ], "additional_components": [ "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P25157", "FBgn0000384", "species_29438", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10434923": { "compartment": "compartment_70101", "id": "reaction_10434923", "reactome": "R-DME-114544", "name": "p115-RhoGEF activation of RHOA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10434904" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10434920", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "A1ZAN6", "FBgn0023172", "P25157", "FBgn0000384", "species_29438" ] }, "reaction_10446858": { "compartment": "compartment_70101", "id": "reaction_10446858", "reactome": "R-DME-398184", "name": "LARG activation by G alpha 12/13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442529", "species_10446850" ], "products": [ "species_10446856" ], "modifiers": [], "additional_components": [ "FBgn0023172", "P25157", "FBgn0000384", "species_29438", "P25157", "FBgn0000384", "species_29438", "A1ZAN6", "FBgn0023172" ] }, "reaction_10447654": { "compartment": "compartment_70101", "id": "reaction_10447654", "reactome": "R-DME-419166", "name": "GEFs activate RhoA,B,C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447308" ], "products": [ "species_29420", "species_10434906" ], "modifiers": [ [ "species_10442560", "catalyst" ] ], "additional_components": [ "species_29420", "P48148", "Rho1", "P48148", "Rho1", "species_29438", "A1ZAN6", "FBgn0023172", "A1ZBA1", "FBgn0050115", "Q9W0S2", "FBgn0264707", "Q8IQ97", "FBgn0003041", "A8DZ19", "FBgn0015803", "Q9VVC6", "FBgn0261547", "Q7K4E0", "FBgn0050440", "P26675", "Sos", "P91621", "FBgn0085447", "M9PBE1", "FBgn0032796", "M9ND00", "FBgn0023388", "X2JC00", "FBgn0025836", "P25157", "FBgn0000384", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VW85", "FBgn0261556" ] }, "reaction_10497274": { "compartment": "compartment_70101", "id": "reaction_10497274", "reactome": "R-DME-9603279", "name": "PIP3 recruits PDK1 and AKT to the membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179838", "species_10441880", "species_10446639" ], "products": [ "species_10497272" ], "modifiers": [], "additional_components": [ "Q8INB9", "phospho-Akt1", "Q9W0V1", "Pdk1", "species_179838" ] }, "reaction_10495392": { "compartment": "compartment_876", "id": "reaction_10495392", "reactome": "R-DME-8964634", "name": "CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495375", "species_10439137" ], "products": [ "species_10495381" ], "modifiers": [], "additional_components": [ "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "FBgn0010341", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495379": { "compartment": "compartment_876", "id": "reaction_10495379", "reactome": "R-DME-8964599", "name": "Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495377" ], "products": [ "species_10434579", "species_10439139", "species_10442520", "species_10446511" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29438", "P40793", "FBgn0010341", "FBgn0015803", "FBgn0267698" ] }, "reaction_10495384": { "compartment": "compartment_876", "id": "reaction_10495384", "reactome": "R-DME-8964604", "name": "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495381" ], "products": [ "species_10495377" ], "modifiers": [ [ "species_10495381", "catalyst" ] ], "additional_components": [ "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495386": { "compartment": "compartment_70101", "id": "reaction_10495386", "reactome": "R-DME-8964605", "name": "PAK1:ARHGEF6 complex binds G-protein beta-gamma complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495373", "species_10434579" ], "products": [ "species_10495375" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495388": { "compartment": "compartment_876", "id": "reaction_10495388", "reactome": "R-DME-8964614", "name": "PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495377" ], "products": [ "species_10495377" ], "modifiers": [], "additional_components": [ "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803", "species_29438", "P40793", "FBgn0010341", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10495390": { "compartment": "compartment_70101", "id": "reaction_10495390", "reactome": "R-DME-8964619", "name": "PAK1 binds ARHGEF6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442520", "species_10446511" ], "products": [ "species_10495373" ], "modifiers": [], "additional_components": [ "FBgn0015803", "FBgn0267698", "B7Z0W0", "FBgn0267698", "A8DZ19", "FBgn0015803" ] }, "reaction_10446527": { "compartment": "compartment_70101", "id": "reaction_10446527", "reactome": "R-DME-389788", "name": "Activation of PAKs by RAC1 and CDC42", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446523", "species_10446509" ], "products": [ "species_10446525", "species_10446511" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698" ] }, "reaction_10478015": { "compartment": "compartment_7660", "id": "reaction_10478015", "reactome": "R-DME-5692749", "name": "CDC14A,B bind MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478007", "species_10478009" ], "products": [ "species_10478013" ], "modifiers": [], "additional_components": [ "FBgn0003256", "FBgn0031952", "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256" ] }, "reaction_10476696": { "compartment": "compartment_7660", "id": "reaction_10476696", "reactome": "R-DME-5687097", "name": "p-S857 NCOA3 binds ETV4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476692", "species_10476677" ], "products": [ "species_10476694" ], "modifiers": [], "additional_components": [ "FBgn0039225", "FBgn0041092", "M9ND53", "FBgn0041092", "Q8MRW5", "FBgn0039225" ] }, "reaction_10476719": { "compartment": "compartment_70101", "id": "reaction_10476719", "reactome": "R-DME-5687126", "name": "p-S215 FOXO3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476700" ], "products": [ "species_10476687" ], "modifiers": [], "additional_components": [] }, "reaction_10476715": { "compartment": "compartment_70101", "id": "reaction_10476715", "reactome": "R-DME-5687112", "name": "MAPK6 is degraded by the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476662" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0003256", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10478027": { "compartment": "compartment_7660", "id": "reaction_10478027", "reactome": "R-DME-5692764", "name": "MAPK6 binds CCND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476706", "species_10457981" ], "products": [ "species_10478025" ], "modifiers": [ [ "species_10478009", "catalyst" ] ], "additional_components": [ "FBgn0003256", "FBgn0010315", "Q7KUZ5", "FBgn0010315", "P40417", "FBgn0003256", "FBgn0031952" ] }, "reaction_10476682": { "compartment": "compartment_7660", "id": "reaction_10476682", "reactome": "R-DME-5687090", "name": "p-S MAPK6 phosphorylates NCOA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10476674" ], "products": [ "species_113582", "species_10476677" ], "modifiers": [ [ "species_10476679", "catalyst" ] ], "additional_components": [ "FBgn0041092", "FBgn0041092", "FBgn0003256" ] }, "reaction_10476712": { "compartment": "compartment_7660", "id": "reaction_10476712", "reactome": "R-DME-5687109", "name": "MAPK4,6 translocate to the cytoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476708" ], "products": [ "species_10476702" ], "modifiers": [ [ "species_10437629", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "FBgn0020497" ] }, "reaction_10478023": { "compartment": "compartment_7660", "id": "reaction_10478023", "reactome": "R-DME-5692755", "name": "CDK1 phosphorylates MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10476706" ], "products": [ "species_113582", "species_10478007" ], "modifiers": [ [ "species_10437599", "catalyst" ] ], "additional_components": [ "FBgn0003256", "FBgn0003256", "FBgn0004106" ] }, "reaction_10476710": { "compartment": "compartment_70101", "id": "reaction_10476710", "reactome": "R-DME-5687107", "name": "MAPK4,6 translocate to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476702" ], "products": [ "species_10476708" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10478020": { "compartment": "compartment_7660", "id": "reaction_10478020", "reactome": "R-DME-5692754", "name": "CDC14A,B dephosphorylate p-3S,T MAPK6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10478013" ], "products": [ "species_113550", "species_10478017" ], "modifiers": [ [ "species_10478013", "catalyst" ] ], "additional_components": [ "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256", "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256", "Q9VLW7", "FBgn0031952", "P40417", "FBgn0003256" ] }, "reaction_10476672": { "compartment": "compartment_70101", "id": "reaction_10476672", "reactome": "R-DME-5687086", "name": "PAK1,2,3 phosphorylates MAPK6,4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10476664" ], "products": [ "species_29370", "species_10476667" ], "modifiers": [ [ "species_10447061", "catalyst" ] ], "additional_components": [ "FBgn0003256", "FBgn0003256", "FBgn0267698" ] }, "reaction_10498144": { "compartment": "compartment_12045", "id": "reaction_10498144", "reactome": "R-DME-9647977", "name": "ICMT methylates S-Farn RAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498135", "species_71284" ], "products": [ "species_10498140", "species_71285" ], "modifiers": [ [ "species_10480013", "catalyst" ], [ "species_10498142", "inhibitor" ] ], "additional_components": [ "Q9VU37", "FBgn0036336", "species_1562550", "Q9VU37", "FBgn0036336", "species_1562550" ] }, "reaction_10498305": { "compartment": "compartment_17906", "id": "reaction_10498305", "reactome": "R-DME-9653592", "name": "pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498284" ], "products": [ "species_10498303" ], "modifiers": [], "additional_components": [] }, "reaction_10498183": { "compartment": "compartment_876", "id": "reaction_10498183", "reactome": "R-DME-9647991", "name": "Palmostatin B binds RAS depalmitoylases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9647934", "species_10498179" ], "products": [ "species_10498181" ], "modifiers": [], "additional_components": [ "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096", "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096" ] }, "reaction_10498311": { "compartment": "compartment_876", "id": "reaction_10498311", "reactome": "R-DME-9654521", "name": "Calmodulin dissociates KRAS4B from the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469704" ], "products": [ "species_10498309" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10498186": { "compartment": "compartment_876", "id": "reaction_10498186", "reactome": "R-DME-9647994", "name": "RAS proteins are depalmitoylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437905", "species_29356" ], "products": [ "species_10437907", "species_8848337" ], "modifiers": [ [ "species_10498179", "catalyst" ], [ "species_10498181", "inhibitor" ] ], "additional_components": [ "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096", "M9PEW1", "FBgn0042138", "A0A4D6K2Q0", "FBgn0053096" ] }, "reaction_10498157": { "compartment": "compartment_70101", "id": "reaction_10498157", "reactome": "R-DME-9647978", "name": "pro-RAS proteins are farnesylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498147", "species_2530486" ], "products": [ "species_111294", "species_10498151" ], "modifiers": [ [ "species_10466175", "catalyst" ], [ "species_10498155", "inhibitor" ] ], "additional_components": [ "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424", "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424" ] }, "reaction_10498317": { "compartment": "compartment_70101", "id": "reaction_10498317", "reactome": "R-DME-9654523", "name": "ARL2:GTP bind PDE6D on KRAS4B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471169", "species_10498313" ], "products": [ "species_10498315" ], "modifiers": [], "additional_components": [ "Q06849", "FBgn0004908", "species_29438", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "Q06849", "FBgn0004908", "species_29438" ] }, "reaction_10498192": { "compartment": "compartment_12045", "id": "reaction_10498192", "reactome": "R-DME-9647999", "name": "RCE1 cleaves S-Farn proRAS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498151" ], "products": [ "species_10498135" ], "modifiers": [ [ "species_10498189", "catalyst" ] ], "additional_components": [ "FBgn0029121" ] }, "reaction_10498321": { "compartment": "compartment_70101", "id": "reaction_10498321", "reactome": "R-DME-9654525", "name": "PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473927", "species_10498309" ], "products": [ "species_10498313" ], "modifiers": [ [ "species_10498319", "inhibitor" ] ], "additional_components": [ "FBgn0032059", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "Q9VLJ0", "FBgn0032059" ] }, "reaction_10498194": { "compartment": "compartment_12045", "id": "reaction_10498194", "reactome": "R-DME-9649732", "name": "Mature S-Farn-Me KRAS4B translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498140" ], "products": [ "species_10437907" ], "modifiers": [], "additional_components": [] }, "reaction_10498196": { "compartment": "compartment_876", "id": "reaction_10498196", "reactome": "R-DME-9649733", "name": "mature p21 RAS binds GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29420", "species_10437899" ], "products": [ "species_10438980" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29420" ] }, "reaction_10498324": { "compartment": "compartment_876", "id": "reaction_10498324", "reactome": "R-DME-9654533", "name": "KRAS4B recycles to the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498315" ], "products": [ "species_10471169", "species_10434387", "species_10437907", "species_10473927" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9VLJ0", "FBgn0032059", "Q06849", "FBgn0004908", "species_29438", "Q06849", "FBgn0004908", "species_29438", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "FBgn0032059" ] }, "reaction_10498293": { "compartment": "compartment_70101", "id": "reaction_10498293", "reactome": "R-DME-9653503", "name": "KRAS4B is phosphorylated on serine 181", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437907", "species_113592" ], "products": [ "species_10498284", "species_29370" ], "modifiers": [ [ "species_10498290", "catalyst" ] ], "additional_components": [ "Q9VL34", "FBgn0032187", "Q03043", "FBgn0000721", "Q03042", "FBgn0000442", "species_30991", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10498166": { "compartment": "compartment_876", "id": "reaction_10498166", "reactome": "R-DME-9647980", "name": "mature RAS proteins translocate to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498160" ], "products": [ "species_10437905" ], "modifiers": [], "additional_components": [] }, "reaction_10498168": { "compartment": "compartment_70101", "id": "reaction_10498168", "reactome": "R-DME-9647987", "name": "FNTB inhibitors bind FNTA:FNTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9653479", "species_10466175" ], "products": [ "species_10498155" ], "modifiers": [], "additional_components": [ "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424", "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424" ] }, "reaction_10498298": { "compartment": "compartment_12045", "id": "reaction_10498298", "reactome": "R-DME-9653514", "name": "USP17L2 deubiquitinates RCE1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498189", "species_29356" ], "products": [ "species_10498295", "species_10477101" ], "modifiers": [ [ "species_10479178", "catalyst" ] ], "additional_components": [ "FBgn0029121", "FBgn0029121", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0260936" ] }, "reaction_10498300": { "compartment": "compartment_876", "id": "reaction_10498300", "reactome": "R-DME-9653585", "name": "S-Farn-Me KRAS4B binds calmodulin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10437907" ], "products": [ "species_10469704" ], "modifiers": [ [ "species_10498284", "inhibitor" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P08646", "RAS85D", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10498350": { "compartment": "compartment_876", "id": "reaction_10498350", "reactome": "R-DME-9658253", "name": "RAS:GTP binds PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10431820" ], "products": [ "species_10498348" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "species_29438", "P08646", "RAS85D" ] }, "reaction_10498362": { "compartment": "compartment_876", "id": "reaction_10498362", "reactome": "R-DME-9660557", "name": "RAS:GTP binds RAL GDS proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498358", "species_10437914" ], "products": [ "species_10498360" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29438", "FBgn0026376", "M9PCE9", "FBgn0026376", "P08646", "RAS85D", "species_29438" ] }, "reaction_10475845": { "compartment": "compartment_876", "id": "reaction_10475845", "reactome": "R-DME-5672965", "name": "RAS GEFs promote RAS nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475842", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "P26675", "Sos", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9V3C8", "FBgn0015296", "species_190915", "Q09147", "FBgn0285896", "Q9VDT9", "FBgn0014135", "Q5BIB8", "FBgn0087011", "Q4V4U2", "FBgn0050280", "Q07407", "FBgn0010389", "Q9VV98", "FBgn0036659", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "P00528", "FBgn0262733", "Q9VR25", "FBgn0031627", "B7Z153", "FBgn0259245", "Q8IP70", "FBgn0051814", "Q9VMN9", "FBgn0031725", "A8JNC7", "FBgn0085420", "Q59E14", "FBgn0053543", "Q9VLF0", "FBgn0051708", "Q9W4R3", "FBgn0052791", "Q24372", "FBgn0010238", "Q9VAR6", "FBgn0039617", "Q9VWP6", "FBgn0030964", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "Q9VQM8", "FBgn0085422", "Q7KTU3", "FBgn0037188", "A1ZAU6", "FBgn0034230", "Q9XTN2", "chico", "Q9VLL4", "FBgn0032042", "Q9VMF3", "FBgn0265778" ] }, "reaction_10498201": { "compartment": "compartment_876", "id": "reaction_10498201", "reactome": "R-DME-9649736", "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909" ], "products": [ "species_10438980" ], "modifiers": [ [ "species_10437909", "catalyst" ] ], "additional_components": [ "species_29438", "P08646", "RAS85D", "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D" ] }, "reaction_10476045": { "compartment": "compartment_876", "id": "reaction_10476045", "reactome": "R-DME-5675417", "name": "PEBP1 binds activated RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475910", "species_10475915" ], "products": [ "species_10475917" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0037432", "Q9VI08", "FBgn0037432", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10490146": { "compartment": "compartment_70101", "id": "reaction_10490146", "reactome": "R-DME-8868118", "name": "MAPK12 phosphorylates PTPN3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10490103" ], "products": [ "species_10490143", "species_29370" ], "modifiers": [ [ "species_10490103", "catalyst" ] ], "additional_components": [ "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985" ] }, "reaction_10476043": { "compartment": "compartment_70101", "id": "reaction_10476043", "reactome": "R-DME-5675376", "name": "Cytosolic DUSPs dephosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10475991" ], "products": [ "species_29372", "species_10476027" ], "modifiers": [ [ "species_10476040", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q9VVW5", "FBgn0036844" ] }, "reaction_10475978": { "compartment": "compartment_20699", "id": "reaction_10475978", "reactome": "R-DME-5674140", "name": "PAQR3 binds inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475782", "species_10475974" ], "products": [ "species_10475976" ], "modifiers": [], "additional_components": [ "FBgn0038256", "Q9VFG7", "FBgn0038256", "P11346", "Raf" ] }, "reaction_10476055": { "compartment": "compartment_876", "id": "reaction_10476055", "reactome": "R-DME-5675431", "name": "PP2A dephosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476049", "species_29356" ], "products": [ "species_29372", "species_10476053" ], "modifiers": [ [ "species_10440527", "catalyst" ], [ "species_10476009", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P29310", "14-3-3zeta", "P11346", "Raf", "species_29438", "P08646", "RAS85D" ] }, "reaction_10490105": { "compartment": "compartment_70101", "id": "reaction_10490105", "reactome": "R-DME-8867654", "name": "PTPN3 binds p-T183,Y185 MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490101", "species_10450702" ], "products": [ "species_10490103" ], "modifiers": [], "additional_components": [ "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985" ] }, "reaction_10490108": { "compartment": "compartment_70101", "id": "reaction_10490108", "reactome": "R-DME-8867658", "name": "PTPN3 dephosphorylates MAPK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490103" ], "products": [ "species_29372", "species_10490101", "species_10451567" ], "modifiers": [ [ "species_10490103", "catalyst" ] ], "additional_components": [ "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985", "FBgn0261985", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "P83100", "FBgn0267339", "O62618", "FBgn0015765", "O61443", "FBgn0024846", "Q9W0R3", "FBgn0261985" ] }, "reaction_10476011": { "compartment": "compartment_876", "id": "reaction_10476011", "reactome": "R-DME-5675194", "name": "Activated MAPK phosphorylates RAF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475854" ], "products": [ "species_29370", "species_10476009" ], "modifiers": [ [ "species_10475991", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256" ] }, "reaction_10476019": { "compartment": "compartment_876", "id": "reaction_10476019", "reactome": "R-DME-5675198", "name": "Activated MAPKs phosphorylate BRAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475856", "species_113592" ], "products": [ "species_10476017", "species_29370" ], "modifiers": [ [ "species_10475991", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256" ] }, "reaction_10476002": { "compartment": "compartment_70101", "id": "reaction_10476002", "reactome": "R-DME-5674496", "name": "Activated MAPKs phosphorylate MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475867" ], "products": [ "species_29370", "species_10475999" ], "modifiers": [ [ "species_10475991", "catalyst" ] ], "additional_components": [ "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256" ] }, "reaction_10497901": { "compartment": "compartment_70101", "id": "reaction_10497901", "reactome": "R-DME-9635739", "name": "PTPN7 dephosphorylates p-T,Y-MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497886", "species_29356" ], "products": [ "species_29372", "species_10497898" ], "modifiers": [ [ "species_10497886", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641", "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641", "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641" ] }, "reaction_10476064": { "compartment": "compartment_876", "id": "reaction_10476064", "reactome": "R-DME-5675433", "name": "PP5 dephosphorylates RAF1 S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10475910" ], "products": [ "species_10476049", "species_29372" ], "modifiers": [ [ "species_10476061", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0005777" ] }, "reaction_10497903": { "compartment": "compartment_70101", "id": "reaction_10497903", "reactome": "R-DME-9635743", "name": "PTPN7 binds p-T,Y-MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497884", "species_10458636" ], "products": [ "species_10497886" ], "modifiers": [], "additional_components": [ "FBgn0016641", "P40417", "FBgn0003256", "P40417", "FBgn0003256", "Q9W2F3", "FBgn0016641" ] }, "reaction_10498198": { "compartment": "compartment_876", "id": "reaction_10498198", "reactome": "R-DME-9649735", "name": "Intrinsic nucleotide exchange on RAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475919": { "compartment": "compartment_876", "id": "reaction_10475919", "reactome": "R-DME-5672972", "name": "MAP2Ks and MAPKs bind to the activated RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475906", "species_10475862", "species_10475896", "species_10433742" ], "products": [ "species_10475908" ], "modifiers": [ [ "species_10475917", "inhibitor" ] ], "additional_components": [ "Q24324", "phospho-Dsor1", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0003256", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "Q9VI08", "FBgn0037432", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475967": { "compartment": "compartment_74700", "id": "reaction_10475967", "reactome": "R-DME-5674130", "name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475963" ], "products": [ "species_29370", "species_10475965" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "Q24324", "phospho-Dsor1" ] }, "reaction_10498338": { "compartment": "compartment_876", "id": "reaction_10498338", "reactome": "R-DME-9657599", "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657567", "species_10475908" ], "products": [ "species_10475929" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10475933": { "compartment": "compartment_876", "id": "reaction_10475933", "reactome": "R-DME-5672973", "name": "MAP2Ks phosphorylate MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475922", "species_113592" ], "products": [ "species_10475924", "species_29370" ], "modifiers": [ [ "species_10475922", "catalyst" ], [ "species_10475931", "inhibitor" ], [ "species_10475927", "inhibitor" ], [ "species_10475929", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10498340": { "compartment": "compartment_876", "id": "reaction_10498340", "reactome": "R-DME-9657603", "name": "Dual mechanism MAPK inhibitors bind MAPKs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475922", "species_9657570" ], "products": [ "species_10475931" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10498342": { "compartment": "compartment_876", "id": "reaction_10498342", "reactome": "R-DME-9657606", "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475922", "species_9657574" ], "products": [ "species_10475927" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10475944": { "compartment": "compartment_876", "id": "reaction_10475944", "reactome": "R-DME-5672980", "name": "Dissociation of RAS:RAF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475924" ], "products": [ "species_10475873", "species_10475910", "species_10475896", "species_10433771" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "Q24324", "phospho-Dsor1", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0003256" ] }, "reaction_10475941": { "compartment": "compartment_876", "id": "reaction_10475941", "reactome": "R-DME-5672978", "name": "RAF phosphorylates MAP2K dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475908", "species_113592" ], "products": [ "species_10475922", "species_29370" ], "modifiers": [ [ "species_10475908", "catalyst" ], [ "species_10475939", "inhibitor" ], [ "species_10475929", "inhibitor" ] ], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10498346": { "compartment": "compartment_876", "id": "reaction_10498346", "reactome": "R-DME-9657608", "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475924", "species_9657577" ], "products": [ "species_10498344" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "Q24324", "phospho-Dsor1" ] }, "reaction_10475987": { "compartment": "compartment_20699", "id": "reaction_10475987", "reactome": "R-DME-5674373", "name": "MAP2Ks phosphorylate MAPK at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475982" ], "products": [ "species_10475984", "species_29370" ], "modifiers": [ [ "species_10475982", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10475969": { "compartment": "compartment_74700", "id": "reaction_10475969", "reactome": "R-DME-5674132", "name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475906", "species_10475959", "species_10475961", "species_10433742" ], "products": [ "species_10475963" ], "modifiers": [], "additional_components": [ "Q24324", "phospho-Dsor1", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "P11346", "Raf", "FBgn0003256", "P40417", "FBgn0003256", "P11346", "Raf", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VJL9", "FBgn0028897", "Q24324", "phospho-Dsor1" ] }, "reaction_10475995": { "compartment": "compartment_7660", "id": "reaction_10475995", "reactome": "R-DME-5674387", "name": "Phosphorylated MAPKs translocate into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475991" ], "products": [ "species_10475993" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "P40417", "FBgn0003256" ] }, "reaction_10475803": { "compartment": "compartment_70101", "id": "reaction_10475803", "reactome": "R-DME-5672961", "name": "PP2A dephosphorylates inactive RAFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10475790" ], "products": [ "species_29372", "species_10475798" ], "modifiers": [ [ "species_10440527", "catalyst" ] ], "additional_components": [ "P29310", "14-3-3zeta", "P11346", "Raf", "P11346", "Raf", "P29310", "14-3-3zeta" ] }, "reaction_10475851": { "compartment": "compartment_876", "id": "reaction_10475851", "reactome": "R-DME-5672966", "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475771", "species_10475742" ], "products": [ "species_10475847" ], "modifiers": [ [ "species_10475849", "catalyst" ] ], "additional_components": [ "P29310", "14-3-3zeta", "P11346", "Raf", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "FBgn0030018" ] }, "reaction_10475800": { "compartment": "compartment_70101", "id": "reaction_10475800", "reactome": "R-DME-5672960", "name": "YWHAB dimer dissociates from dephosphorylated RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475798" ], "products": [ "species_10432010", "species_10475742" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "P29310", "14-3-3zeta" ] }, "reaction_10475878": { "compartment": "compartment_876", "id": "reaction_10475878", "reactome": "R-DME-5672969", "name": "Phosphorylation of RAF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475847" ], "products": [ "species_29370", "species_10475862" ], "modifiers": [ [ "species_10475875", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10498281": { "compartment": "compartment_876", "id": "reaction_10498281", "reactome": "R-DME-9653108", "name": "Raf dimer inhibitors bind RAF heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9657579", "species_10475847" ], "products": [ "species_10475939" ], "modifiers": [], "additional_components": [ "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "P29310", "14-3-3zeta", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475778": { "compartment": "compartment_876", "id": "reaction_10475778", "reactome": "R-DME-5672950", "name": "\"Activator\" RAF:YWHAB dimer binds RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10475769" ], "products": [ "species_10475771" ], "modifiers": [ [ "species_10475776", "catalyst" ] ], "additional_components": [ "species_29438", "P08646", "RAS85D", "P29310", "14-3-3zeta", "P11346", "Raf", "P29310", "14-3-3zeta", "P11346", "Raf", "species_29438", "P08646", "RAS85D", "FBgn0002031" ] }, "reaction_10475792": { "compartment": "compartment_70101", "id": "reaction_10475792", "reactome": "R-DME-5672951", "name": "Inactive RAFs bind YWHAB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475782", "species_10432010" ], "products": [ "species_10475790" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "P11346", "Raf" ] }, "reaction_10433759": { "compartment": "compartment_70101", "id": "reaction_10433759", "reactome": "R-DME-109857", "name": "MAP2K1 binds MAPK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433755", "species_10433740" ], "products": [ "species_10433757" ], "modifiers": [], "additional_components": [ "FBgn0003256", "P40417", "FBgn0003256", "Q24324", "phospho-Dsor1" ] }, "reaction_10434596": { "compartment": "compartment_70101", "id": "reaction_10434596", "reactome": "R-DME-112342", "name": "Inactivation of MAP2K1 by CDK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10434587" ], "products": [ "species_10433778", "species_29370" ], "modifiers": [ [ "species_10434593", "catalyst" ] ], "additional_components": [ "Q24324", "phospho-Dsor1", "FBgn0004106" ] }, "reaction_10433794": { "compartment": "compartment_70101", "id": "reaction_10433794", "reactome": "R-DME-109863", "name": "Dissociation of p-T,Y-MAPK3:MAP2K1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433773" ], "products": [ "species_10433755", "species_10433771" ], "modifiers": [], "additional_components": [ "Q24324", "phospho-Dsor1", "P40417", "FBgn0003256", "FBgn0003256" ] }, "reaction_10498724": { "compartment": "compartment_263163", "id": "reaction_10498724", "reactome": "R-DME-9706390", "name": "RHOBTB3 binds interacting proteins at trans-Golgi network", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498720", "species_10498704" ], "products": [ "species_10498722" ], "modifiers": [], "additional_components": [ "Q9VIW6", "FBgn0032782", "P54733", "FBgn0010382", "Q9V3C1", "FBgn0041174", "Q8IP45", "FBgn0261268", "Q9VCI3", "FBgn0039114", "Q9VXY7", "FBgn0030608", "Q960X8", "FBgn0031450", "P20905", "FBgn0004573", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "Q9VIW6", "FBgn0032782", "P54733", "FBgn0010382", "Q9V3C1", "FBgn0041174", "Q8IP45", "FBgn0261268", "Q9VCI3", "FBgn0039114", "Q9VXY7", "FBgn0030608", "Q960X8", "FBgn0031450", "P20905", "FBgn0004573", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011" ] }, "reaction_10498726": { "compartment": "compartment_263163", "id": "reaction_10498726", "reactome": "R-DME-9706393", "name": "RHOBTB3 binds ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498702", "species_113592" ], "products": [ "species_10498704" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011" ] }, "reaction_10498731": { "compartment": "compartment_263163", "id": "reaction_10498731", "reactome": "R-DME-9706399", "name": "RHOBTB3 hydrolyzes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10498704" ], "products": [ "species_29372", "species_10498728" ], "modifiers": [ [ "species_10498704", "catalyst" ] ], "additional_components": [ "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29370", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_113592", "P40792", "RAC1_DROME", "P48554", "FBgn0014011" ] }, "reaction_10496801": { "compartment": "compartment_70101", "id": "reaction_10496801", "reactome": "R-DME-9018814", "name": "RHOT1 hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10496796" ], "products": [ "species_10496798", "species_29372" ], "modifiers": [ [ "species_10496796", "catalyst" ] ], "additional_components": [ "Q8IMX7", "Miro", "species_29438", "Q8IMX7", "Miro", "species_29420", "Q8IMX7", "Miro", "species_29438" ] }, "reaction_10496812": { "compartment": "compartment_17906", "id": "reaction_10496812", "reactome": "R-DME-9018815", "name": "RHOT1 binds effectors at the mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496796", "species_10496806" ], "products": [ "species_10496810" ], "modifiers": [], "additional_components": [ "Q8IMX7", "Miro", "species_29438", "FBgn0262872", "Q960V3", "FBgn0262872", "Q8IMX7", "Miro", "species_29438" ] }, "reaction_10458700": { "compartment": "compartment_876", "id": "reaction_10458700", "reactome": "R-DME-1296046", "name": "KCNJs transport K+ from the extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74126" ], "products": [ "species_29804" ], "modifiers": [ [ "species_10458697", "catalyst" ] ], "additional_components": [ "B7YZX2", "FBgn0032706" ] }, "reaction_10472658": { "compartment": "compartment_70101", "id": "reaction_10472658", "reactome": "R-DME-5578910", "name": "KCNK dimers transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10472655", "catalyst" ] ], "additional_components": [ "Q9VHE0", "FBgn0037690", "Q9VFS9", "FBgn0038165" ] }, "reaction_10472583": { "compartment": "compartment_70101", "id": "reaction_10472583", "reactome": "R-DME-5577213", "name": "LTCC multimer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10472580", "catalyst" ] ], "additional_components": [ "Q9VRE6", "FBgn0064123", "Q24270", "FBgn0001991", "M9PD84", "FBgn0259822", "X2J9Z3", "FBgn0028863", "Q8IP22", "FBgn0261999" ] }, "reaction_10472614": { "compartment": "compartment_876", "id": "reaction_10472614", "reactome": "R-DME-5577234", "name": "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10472611", "catalyst" ] ], "additional_components": [ "P17971", "FBgn0005564", "Q9VBL2", "FBgn0039380", "Q8IR92", "FBgn0265595" ] }, "reaction_10472943": { "compartment": "compartment_876", "id": "reaction_10472943", "reactome": "R-DME-5607755", "name": "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472941" ], "products": [ "species_10472926" ], "modifiers": [], "additional_components": [ "FBgn0003416", "FBgn0003416" ] }, "reaction_10466943": { "compartment": "compartment_70101", "id": "reaction_10466943", "reactome": "R-DME-2730867", "name": "Translocation of CaN:CaM:NFAT to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466879" ], "products": [ "species_10466941" ], "modifiers": [], "additional_components": [ "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_74016", "Q24214", "FBgn0015614", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_1222611", "species_1562550" ] }, "reaction_10466882": { "compartment": "compartment_70101", "id": "reaction_10466882", "reactome": "R-DME-2730849", "name": "Calcineurin binds and dephosphorylates NFAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10464038", "species_10464071" ], "products": [ "species_29372", "species_10466879" ], "modifiers": [ [ "species_10464071", "catalyst" ] ], "additional_components": [ "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614" ] }, "reaction_10472924": { "compartment": "compartment_876", "id": "reaction_10472924", "reactome": "R-DME-5607734", "name": "PKC-delta translocates to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470925", "species_112275" ], "products": [ "species_10472922" ], "modifiers": [], "additional_components": [ "FBgn0259680", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10472939": { "compartment": "compartment_876", "id": "reaction_10472939", "reactome": "R-DME-5607746", "name": "PKC-delta is activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472922" ], "products": [ "species_10472937" ], "modifiers": [], "additional_components": [ "species_112275", "P83099", "FBgn0259680", "species_112275", "P83099", "FBgn0259680" ] }, "reaction_10472929": { "compartment": "compartment_876", "id": "reaction_10472929", "reactome": "R-DME-5607735", "name": "p-Y753,Y759-PLCG2 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10472926", "catalyst" ] ], "additional_components": [ "FBgn0003416" ] }, "reaction_10489499": { "compartment": "compartment_876", "id": "reaction_10489499", "reactome": "R-DME-8858500", "name": "CLEC10A binds Tn-MUC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489495", "species_10489479" ], "products": [ "species_10489497" ], "modifiers": [], "additional_components": [ "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "M9NE79", "FBgn0262357", "M9PB26", "FBgn0264341", "Q59DY5", "FBgn0053533", "Q59DY6", "FBgn0053532", "Q7JY62", "FBgn0040092", "Q8IRH8", "FBgn0035199", "Q9VIX1", "FBgn0016675", "Q9VKL8", "FBgn0040096", "Q9VLM0", "FBgn0040098", "Q9VM16", "FBgn0031910", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "M9NE79", "FBgn0262357", "M9PB26", "FBgn0264341", "Q59DY5", "FBgn0053533", "Q59DY6", "FBgn0053532", "Q7JY62", "FBgn0040092", "Q8IRH8", "FBgn0035199", "Q9VIX1", "FBgn0016675", "Q9VKL8", "FBgn0040096", "Q9VLM0", "FBgn0040098", "Q9VM16", "FBgn0031910", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "Q9VU94", "FBgn0029167", "A1Z877", "FBgn0026403", "Q0KHY3", "FBgn0051004" ] }, "reaction_10473885": { "compartment": "compartment_876", "id": "reaction_10473885", "reactome": "R-DME-5624494", "name": "RAF1 binds p21 RAS:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437909", "species_10446844" ], "products": [ "species_10473881" ], "modifiers": [], "additional_components": [ "species_29438", "P08646", "RAS85D", "P11346", "Raf", "species_29438", "P08646", "RAS85D" ] }, "reaction_10475388": { "compartment": "compartment_7660", "id": "reaction_10475388", "reactome": "R-DME-5660666", "name": "CBP and p300 binds NF-kB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447242", "species_10473850" ], "products": [ "species_10475363" ], "modifiers": [], "additional_components": [ "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "M9MS40", "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10473883": { "compartment": "compartment_876", "id": "reaction_10473883", "reactome": "R-DME-5624492", "name": "PAK phosphorylates p21 RAF1 on S338", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10473881" ], "products": [ "species_29370", "species_10473870" ], "modifiers": [ [ "species_10446511", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "species_29438", "P08646", "RAS85D", "FBgn0267698" ] }, "reaction_10475386": { "compartment": "compartment_7660", "id": "reaction_10475386", "reactome": "R-DME-5660660", "name": "p300 acetylates RELA subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475363", "species_113560" ], "products": [ "species_2485002", "species_10475383" ], "modifiers": [ [ "species_10475363", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "M9MS40", "FBgn0261617", "Q94527", "Rel", "P15330", "dl", "P98149", "Dif", "M9MS40", "FBgn0261617", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10473865": { "compartment": "compartment_7660", "id": "reaction_10473865", "reactome": "R-DME-5624473", "name": "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10437455" ], "products": [ "species_113582", "species_10473850" ], "modifiers": [ [ "species_10473862", "catalyst" ] ], "additional_components": [ "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "Q9V3I5", "FBgn0020412", "P12370", "Pka-C1", "P16911", "FBgn0000274", "Q9VA47", "FBgn0039796" ] }, "reaction_10473879": { "compartment": "compartment_876", "id": "reaction_10473879", "reactome": "R-DME-5624486", "name": "SFKs phosphorylates RAF1 on Y340,Y341", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10473870" ], "products": [ "species_10473876", "species_29370" ], "modifiers": [ [ "species_10444516", "catalyst" ] ], "additional_components": [ "P11346", "Raf", "species_29438", "P08646", "RAS85D", "species_29438", "P08646", "RAS85D", "P11346", "Raf", "FBgn0262733" ] }, "reaction_10475392": { "compartment": "compartment_7660", "id": "reaction_10475392", "reactome": "R-DME-5660980", "name": "p-S276-RELA binds RELB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472931", "species_10473848" ], "products": [ "species_10475390" ], "modifiers": [], "additional_components": [ "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl" ] }, "reaction_10486210": { "compartment": "compartment_7660", "id": "reaction_10486210", "reactome": "R-DME-6805755", "name": "EHMT1:EHMT2 dimethylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10467611" ], "products": [ "species_10486207", "species_77502" ], "modifiers": [ [ "species_10468978", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "M9PGH7", "FBgn0040372" ] }, "reaction_10467770": { "compartment": "compartment_7660", "id": "reaction_10467770", "reactome": "R-DME-3222237", "name": "SMYD2 methylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10427813" ], "products": [ "species_77502", "species_10467762" ], "modifiers": [ [ "species_10467767", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0011566" ] }, "reaction_10486202": { "compartment": "compartment_7660", "id": "reaction_10486202", "reactome": "R-DME-6805740", "name": "SETD8 methylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10427813" ], "products": [ "species_10467744", "species_77502" ], "modifiers": [ [ "species_10486199", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0011474" ] }, "reaction_10467748": { "compartment": "compartment_7660", "id": "reaction_10467748", "reactome": "R-DME-3222116", "name": "L3MBTL1 binds TP53 monomethylated on K382", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467744", "species_10467739" ], "products": [ "species_10467746" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0002441", "Q9VB52", "FBgn0002441", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10479851": { "compartment": "compartment_12045", "id": "reaction_10479851", "reactome": "R-DME-6786239", "name": "CYP4V2 omega-hydroxylates DHA to HDoHE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6786220", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_6786225" ], "modifiers": [ [ "species_10479848", "catalyst" ] ], "additional_components": [ "FBgn0015032" ] }, "reaction_10440259": { "compartment": "compartment_70101", "id": "reaction_10440259", "reactome": "R-DME-193060", "name": "CYP19A1 hydroxylates ANDST to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_193079", "species_29364" ], "products": [ "species_29356", "species_193066", "species_29366", "species_29460" ], "modifiers": [ [ "species_10440256", "catalyst" ] ], "additional_components": [ "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395" ] }, "reaction_10428799": { "compartment": "compartment_70101", "id": "reaction_10428799", "reactome": "R-DME-71303", "name": "RPE dimers isomerise RU5P to XY5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29732" ], "products": [ "species_29790" ], "modifiers": [ [ "species_10428796", "catalyst" ] ], "additional_components": [ "Q95RV5", "FBgn0050499", "species_111793" ] }, "reaction_10428829": { "compartment": "compartment_70101", "id": "reaction_10428829", "reactome": "R-DME-71335", "name": "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790", "species_29878" ], "products": [ "species_29578", "species_29512" ], "modifiers": [ [ "species_10428814", "catalyst" ] ], "additional_components": [ "Q9VHN7", "FBgn0037607", "species_29926", "species_8878387" ] }, "reaction_10428827": { "compartment": "compartment_70101", "id": "reaction_10428827", "reactome": "R-DME-71334", "name": "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29578", "species_29882" ], "products": [ "species_29512", "species_29878" ], "modifiers": [ [ "species_10428824", "catalyst" ] ], "additional_components": [ "Q9W1G0", "FBgn0023477" ] }, "reaction_10495142": { "compartment": "compartment_70101", "id": "reaction_10495142", "reactome": "R-DME-8955844", "name": "RBKS phosphorylates ribose to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8955853" ], "products": [ "species_73578", "species_29370" ], "modifiers": [ [ "species_10495139", "catalyst" ] ], "additional_components": [ "FBgn0025640" ] }, "reaction_10436633": { "compartment": "compartment_70101", "id": "reaction_10436633", "reactome": "R-DME-163741", "name": "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate ", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29882", "species_29578" ], "products": [ "species_29790", "species_73578" ], "modifiers": [ [ "species_10428814", "catalyst" ] ], "additional_components": [ "Q9VHN7", "FBgn0037607", "species_29926", "species_8878387" ] }, "reaction_10495719": { "compartment": "compartment_70101", "id": "reaction_10495719", "reactome": "R-DME-8982667", "name": "PGM2:Mg2+ isomerises dR1P to dR5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787326" ], "products": [ "species_6787328" ], "modifiers": [ [ "species_10427848", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z7P1", "FBgn0033377" ] }, "reaction_10427926": { "compartment": "compartment_70101", "id": "reaction_10427926", "reactome": "R-DME-70377", "name": "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30537", "species_29366" ], "products": [ "species_70106", "species_31467", "species_29364" ], "modifiers": [ [ "species_10427923", "catalyst" ] ], "additional_components": [ "P12646", "FBgn0004057", "species_29366" ] }, "reaction_10438837": { "compartment": "compartment_70101", "id": "reaction_10438837", "reactome": "R-DME-177784", "name": "ribose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10428804", "catalyst" ] ], "additional_components": [ "FBgn0050410" ] }, "reaction_10434100": { "compartment": "compartment_70101", "id": "reaction_10434100", "reactome": "R-DME-111215", "name": "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_110644" ], "products": [ "species_73566", "species_109386" ], "modifiers": [ [ "species_10430909", "catalyst" ], [ "species_29372", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VT33", "FBgn0036030" ] }, "reaction_10430912": { "compartment": "compartment_70101", "id": "reaction_10430912", "reactome": "R-DME-73580", "name": "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73578", "species_113592" ], "products": [ "species_73566", "species_76577" ], "modifiers": [ [ "species_10430909", "catalyst" ] ], "additional_components": [ "Q9VT33", "FBgn0036030" ] }, "reaction_10479918": { "compartment": "compartment_70101", "id": "reaction_10479918", "reactome": "R-DME-6787329", "name": "PGM2:Mg2+ isomerises R1P to R5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_112016" ], "products": [ "species_73578" ], "modifiers": [ [ "species_10427848", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z7P1", "FBgn0033377" ] }, "reaction_10428779": { "compartment": "compartment_70101", "id": "reaction_10428779", "reactome": "R-DME-71299", "name": "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29996", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_29732" ], "modifiers": [ [ "species_10428776", "catalyst" ] ], "additional_components": [ "P41572", "FBgn0004654" ] }, "reaction_10479915": { "compartment": "compartment_70101", "id": "reaction_10479915", "reactome": "R-DME-6787321", "name": "DERA cleaves dR5P to GA3P and CH3CHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787328" ], "products": [ "species_29578", "species_29510" ], "modifiers": [ [ "species_10479912", "catalyst" ] ], "additional_components": [ "FBgn0033735" ] }, "reaction_10441190": { "compartment": "compartment_70101", "id": "reaction_10441190", "reactome": "R-DME-199803", "name": "xylulose 5-phosphate <=> D-ribulose 5-phosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29790" ], "products": [ "species_29732" ], "modifiers": [ [ "species_10428796", "catalyst" ] ], "additional_components": [ "Q95RV5", "FBgn0050499", "species_111793" ] }, "reaction_10428769": { "compartment": "compartment_70101", "id": "reaction_10428769", "reactome": "R-DME-71296", "name": "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31467" ], "products": [ "species_29996" ], "modifiers": [ [ "species_10428766", "catalyst" ] ], "additional_components": [ "FBgn0030239" ] }, "reaction_214393": { "compartment": "compartment_70101", "id": "reaction_214393", "reactome": "R-DME-214393", "name": "Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Phosphorylated Relish (REL) is endoproteolytically cleaved by the caspase-8 orthologue, DREDD, between residues Asp545 and Gly546 at a consensus target site for group III caspases found in the interdomain linker. The two cleavage products, REL-68 and REL-49, dissociate from DREDD.", "reactants": [ "species_214409" ], "products": [ "species_205709", "species_354270", "species_214404" ], "modifiers": [ [ "species_205876", "catalyst" ] ], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4" ] }, "reaction_209167": { "compartment": "compartment_70101", "id": "reaction_209167", "reactome": "R-DME-209167", "name": "Phosphorylated REL is cleaved by and dissociates from DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Phosphorylated Relish (REL) is endoproteolytically cleaved by the caspase-8 orthologue, DREDD, between residues Asp545 and Gly546 at a consensus target site for group III caspases found in the interdomain linker. The two cleavage products, REL-68 and REL-49, dissociate from DREDD.", "reactants": [ "species_354322" ], "products": [ "species_205709", "species_354270", "species_354317" ], "modifiers": [ [ "species_205876", "catalyst" ] ], "additional_components": [ "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_10436024": { "compartment": "compartment_12045", "id": "reaction_10436024", "reactome": "R-DME-162721", "name": "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449299" ], "products": [ "species_29420", "species_162681" ], "modifiers": [ [ "species_10436021", "catalyst" ] ], "additional_components": [ "E1JIA5", "FBgn0259933", "Q9VIU7", "FBgn0032799", "Q2PDR0", "FBgn0053977" ] }, "reaction_10457726": { "compartment": "compartment_70101", "id": "reaction_10457726", "reactome": "R-DME-1112538", "name": "Phosphorylated STAT1, STAT3 form dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718" ], "products": [ "species_10457724" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10457736": { "compartment": "compartment_70101", "id": "reaction_10457736", "reactome": "R-DME-1112587", "name": "STAT1 and STAT3 dimers translocate to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457724" ], "products": [ "species_10457734" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10466124": { "compartment": "compartment_70101", "id": "reaction_10466124", "reactome": "R-DME-2514867", "name": "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112", "species_74113" ], "products": [ "species_83910", "species_74016" ], "modifiers": [ [ "species_10431457", "catalyst" ] ], "additional_components": [ "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_30991" ] }, "reaction_10466121": { "compartment": "compartment_70101", "id": "reaction_10466121", "reactome": "R-DME-2514865", "name": "cGMP dissociates from CNG channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431457" ], "products": [ "species_30991", "species_10431455" ], "modifiers": [], "additional_components": [ "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_30991", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145" ] }, "reaction_10467853": { "compartment": "compartment_70101", "id": "reaction_10467853", "reactome": "R-DME-3229181", "name": "CALM1:Ca2+ binds CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10431455" ], "products": [ "species_10467851" ], "modifiers": [ [ "species_74016", "catalyst" ] ], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10466231": { "compartment": "compartment_70101", "id": "reaction_10466231", "reactome": "R-DME-2586748", "name": "GUCA binds Ca2+ to form GUCA:Ca2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466229", "species_74016" ], "products": [ "species_10431940" ], "modifiers": [], "additional_components": [ "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303" ] }, "reaction_10431958": { "compartment": "compartment_2514888", "id": "reaction_10431958", "reactome": "R-DME-74885", "name": "GUCYs converts GTP to cGMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438" ], "products": [ "species_111294", "species_30991" ], "modifiers": [ [ "species_10431905", "catalyst" ], [ "species_10431946", "catalyst" ], [ "species_10431952", "catalyst" ], [ "species_10431940", "inhibitor" ], [ "species_10431954", "inhibitor" ], [ "species_10431956", "inhibitor" ] ], "additional_components": [ "FBgn0085386", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303", "species_74016", "Q9VW66", "FBgn0036926", "P42325", "FBgn0013303" ] }, "reaction_10431459": { "compartment": "compartment_70101", "id": "reaction_10431459", "reactome": "R-DME-74031", "name": "cGMP binds CNG channel to form cGMP:CNG channel", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991", "species_10431455" ], "products": [ "species_10431457" ], "modifiers": [], "additional_components": [ "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "Q9W2D5", "FBgn0266346", "Q24278", "FBgn0261612", "A0A4P7VAE4", "FBgn0259145", "species_30991" ] }, "reaction_10479843": { "compartment": "compartment_70101", "id": "reaction_10479843", "reactome": "R-DME-6786205", "name": "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428994", "species_71284" ], "products": [ "species_71285", "species_10479835" ], "modifiers": [ [ "species_10479840", "catalyst" ] ], "additional_components": [ "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "Q9W2L0", "FBgn0034592", "P47947", "FBgn0013348", "Q9VMT2", "FBgn0031692", "A1Z777", "FBgn0050378", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "P48593", "FBgn0004910", "FBgn0032857" ] }, "reaction_10466178": { "compartment": "compartment_2514888", "id": "reaction_10466178", "reactome": "R-DME-2530501", "name": "FNTA:FNTB transfers FARN to GNGT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466165", "species_2530486" ], "products": [ "species_111294", "species_10466168" ], "modifiers": [ [ "species_10466175", "catalyst" ] ], "additional_components": [ "FBgn0004921", "FBgn0004921", "Q9VR31", "FBgn0031633", "Q9VEV7", "FBgn0038424" ] }, "reaction_10443513": { "compartment": "compartment_984", "id": "reaction_10443513", "reactome": "R-DME-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_171149", "species_194276" ], "products": [ "species_194236", "species_171076" ], "modifiers": [ [ "species_10443510", "catalyst" ] ], "additional_components": [ "Q9I7L9", "FBgn0042175", "Q9Y168", "FBgn0051683" ] }, "reaction_10495519": { "compartment": "compartment_984", "id": "reaction_10495519", "reactome": "R-DME-8980228", "name": "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_174602", "species_174675" ], "modifiers": [ [ "species_10495516", "catalyst" ] ], "additional_components": [ "A1ZAL5", "FBgn0034166", "A8DYT7", "FBgn0085477", "M9MRT1", "FBgn0032289", "M9NFL7", "FBgn0036977", "P02843", "FBgn0004045", "P02844", "FBgn0005391", "P06607", "FBgn0004047", "Q0E8T1", "FBgn0250847", "Q4V566", "FBgn0085476", "Q7K3Z8", "FBgn0032029", "Q9VB88", "FBgn0039476", "Q9VB89", "FBgn0039475", "Q9VB90", "FBgn0039474", "Q9VB91", "FBgn0039473", "Q9VB92", "FBgn0039472", "Q9VB93", "FBgn0039471", "Q9VB94", "FBgn0039470", "Q9VBQ2", "FBgn0039344", "Q9VEY9", "FBgn0038398", "Q9VJH1", "FBgn0032612", "Q9VLU1", "FBgn0031976", "Q9VRW5", "FBgn0035697", "Q9VU78", "FBgn0036367", "Q9VX01", "FBgn0030884", "Q9VX69", "FBgn0030828", "Q9VX70", "FBgn0265267", "Q9VZN6", "FBgn0035453", "Q9W304", "FBgn0030162", "Q9W448", "FBgn0029831" ] }, "reaction_10459822": { "compartment": "compartment_70616", "id": "reaction_10459822", "reactome": "R-DME-1483165", "name": "PA is converted to CDP-DAG by CDS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524101", "species_110577" ], "products": [ "species_159450", "species_1524064" ], "modifiers": [ [ "species_10459819", "catalyst" ] ], "additional_components": [ "FBgn0010350" ] }, "reaction_10474159": { "compartment": "compartment_18730", "id": "reaction_10474159", "reactome": "R-DME-5625416", "name": "Anterograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474075" ], "products": [ "species_10474157" ], "modifiers": [], "additional_components": [ "Q9VUY2", "FBgn0036567", "Q9VQA6", "FBgn0028570", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q7KMS3", "FBgn0024196", "Q0E8P6", "FBgn0023096", "Q9VLB9", "FBgn0032119", "species_29438", "species_29420", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "Q9VRK9", "FBgn0004380", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9W097", "FBgn0035264", "Q9VSJ6", "FBgn0265102", "Q7KRS6", "FBgn0016919", "Q9VFL0", "FBgn0038221", "Q9W040", "FBgn0035317", "Q9VII8", "FBgn0032891", "Q9VJ72", "FBgn0032692", "Q9VK41", "FBgn0032470", "Q9VQS5", "FBgn0031550", "Q9VF41", "FBgn0038358", "Q9VMC0", "FBgn0031829", "Q9VR64", "FBgn0031196", "A1Z6F0", "FBgn0050441", "A1Z6F0", "FBgn0050441", "Q9W040", "FBgn0035317", "Q9VK41", "FBgn0032470", "Q9VF41", "FBgn0038358", "Q9VR64", "FBgn0031196", "Q9VFL0", "FBgn0038221", "Q7KRS6", "FBgn0016919", "Q9VII8", "FBgn0032891", "Q9VQS5", "FBgn0031550", "Q9VMC0", "FBgn0031829", "Q9VJ72", "FBgn0032692", "Q9VLB9", "FBgn0032119", "Q24117", "FBgn0011760", "Q7KMS3", "FBgn0024196", "Q9VQA6", "FBgn0028570", "O96860", "FBgn0026141", "Q9VUY2", "FBgn0036567", "Q0E8P6", "FBgn0023096", "A1ZBM3", "FBgn0034452", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264", "Q9VZ07", "FBgn0028421", "Q9VRK9", "FBgn0004380", "P46867", "FBgn0004381", "species_29438", "species_29420" ] }, "reaction_10474169": { "compartment": "compartment_18730", "id": "reaction_10474169", "reactome": "R-DME-5625426", "name": "Retrograde IFT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474167" ], "products": [ "species_10474163" ], "modifiers": [], "additional_components": [ "A1Z6F0", "FBgn0050441", "Q9W040", "FBgn0035317", "Q9VK41", "FBgn0032470", "Q9VF41", "FBgn0038358", "Q9VR64", "FBgn0031196", "Q9VFL0", "FBgn0038221", "Q7KRS6", "FBgn0016919", "Q9VII8", "FBgn0032891", "Q9VQS5", "FBgn0031550", "Q9VMC0", "FBgn0031829", "Q9VJ72", "FBgn0032692", "Q9VZ07", "FBgn0028421", "Q9VRK9", "FBgn0004380", "P46867", "FBgn0004381", "Q9VLB9", "FBgn0032119", "Q24117", "FBgn0011760", "Q7KMS3", "FBgn0024196", "Q9VQA6", "FBgn0028570", "O96860", "FBgn0026141", "Q9VUY2", "FBgn0036567", "Q0E8P6", "FBgn0023096", "species_29438", "species_29420", "A1ZBM3", "FBgn0034452", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "Q9VSJ6", "FBgn0265102", "Q9W097", "FBgn0035264", "Q9VK67", "FBgn0032446", "Q7KTZ4", "FBgn0260933", "A1ZBM3", "FBgn0034452", "Q9W097", "FBgn0035264", "Q9VSJ6", "FBgn0265102", "Q7KRS6", "FBgn0016919", "Q9VFL0", "FBgn0038221", "Q9W040", "FBgn0035317", "Q9VII8", "FBgn0032891", "Q9VJ72", "FBgn0032692", "Q9VK41", "FBgn0032470", "Q9VQS5", "FBgn0031550", "Q9VF41", "FBgn0038358", "Q9VMC0", "FBgn0031829", "Q9VR64", "FBgn0031196", "A1Z6F0", "FBgn0050441", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "Q9VRK9", "FBgn0004380", "Q9VUY2", "FBgn0036567", "Q9VQA6", "FBgn0028570", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q7KMS3", "FBgn0024196", "Q0E8P6", "FBgn0023096", "Q9VLB9", "FBgn0032119", "species_29438", "species_29420" ] }, "reaction_10473319": { "compartment": "compartment_20699", "id": "reaction_10473319", "reactome": "R-DME-5617828", "name": "TRIP11:IFT20 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473317" ], "products": [ "species_10473315", "species_10473310" ], "modifiers": [], "additional_components": [ "A1Z6F0", "FBgn0050441", "A0A4D6K5M0", "FBgn0027287", "FBgn0027287", "FBgn0050441" ] }, "reaction_10473908": { "compartment": "compartment_70101", "id": "reaction_10473908", "reactome": "R-DME-5624951", "name": "TNPO1 binds KIF17 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473892", "species_10450986" ], "products": [ "species_10473894" ], "modifiers": [], "additional_components": [ "Q9V4A1", "FBgn0039925", "FBgn0024921", "Q9VRV8", "FBgn0024921", "Q9V4A1", "FBgn0039925" ] }, "reaction_10473904": { "compartment": "compartment_18730", "id": "reaction_10473904", "reactome": "R-DME-5624948", "name": "KIF17 enters the cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473894" ], "products": [ "species_10473902" ], "modifiers": [], "additional_components": [ "Q9VRV8", "FBgn0024921", "Q9V4A1", "FBgn0039925", "Q9VRV8", "FBgn0024921", "Q9V4A1", "FBgn0039925" ] }, "reaction_10458647": { "compartment": "compartment_876", "id": "reaction_10458647", "reactome": "R-DME-1296035", "name": "Activation of Ca2+ activated Potassium channels with Intermediate conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458644", "catalyst" ] ], "additional_components": [ "FBgn0029761" ] }, "reaction_10458658": { "compartment": "compartment_876", "id": "reaction_10458658", "reactome": "R-DME-1296039", "name": "Activation of Ca2+ activated Potassium channels with small conductance", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458655", "catalyst" ] ], "additional_components": [ "Q7KVW5", "FBgn0029761" ] }, "reaction_10448363": { "compartment": "compartment_70101", "id": "reaction_10448363", "reactome": "R-DME-426522", "name": "Nonendonucleolytic RISC binds exactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523", "species_10448341", "species_10448348" ], "products": [ "species_10448361" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035", "FBgn0051992", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035" ] }, "reaction_10448359": { "compartment": "compartment_70101", "id": "reaction_10448359", "reactome": "R-DME-426520", "name": "Endonucleolytic RISC hydrolyzes target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426523" ], "products": [ "species_426511" ], "modifiers": [ [ "species_10448333", "catalyst" ] ], "additional_components": [ "Q32KD4", "FBgn0262739" ] }, "reaction_10448356": { "compartment": "compartment_70101", "id": "reaction_10448356", "reactome": "R-DME-426489", "name": "RISC binds inexactly matching target RNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448343", "species_426515", "species_10448348" ], "products": [ "species_10448354" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035", "FBgn0051992", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739", "Q9VUQ5", "FBgn0087035" ] }, "reaction_10448329": { "compartment": "compartment_70101", "id": "reaction_10448329", "reactome": "R-DME-426464", "name": "Dicer cleaves double-stranded RNA to yield double-stranded siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426463", "species_10442303" ], "products": [ "species_10448326" ], "modifiers": [ [ "species_10442303", "catalyst" ] ], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739" ] }, "reaction_10464903": { "compartment": "compartment_70101", "id": "reaction_10464903", "reactome": "R-DME-2106625", "name": "Duplex siRNA is loaded into Argonaute", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448326" ], "products": [ "species_10464891" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q9VCU9", "FBgn0039016", "Q32KD4", "FBgn0262739", "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016" ] }, "reaction_10496968": { "compartment": "compartment_70101", "id": "reaction_10496968", "reactome": "R-DME-9023909", "name": "C3PO hydrolyzes cleaved passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10496953" ], "products": [ "species_10448331" ], "modifiers": [ [ "species_10496965", "catalyst" ] ], "additional_components": [ "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739", "Q9VF77", "FBgn0038327", "Q7JVK6", "FBgn0033528" ] }, "reaction_10464901": { "compartment": "compartment_70101", "id": "reaction_10464901", "reactome": "R-DME-2106615", "name": "Removal of siRNA passenger strand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464891" ], "products": [ "species_10464899" ], "modifiers": [], "additional_components": [ "Q9VLW8", "FBgn0031951", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VJY9", "FBgn0032515", "Q32KD4", "FBgn0262739", "Q9VCU9", "FBgn0039016", "Q9VLW8", "FBgn0031951" ] }, "reaction_10496971": { "compartment": "compartment_70101", "id": "reaction_10496971", "reactome": "R-DME-9023912", "name": "AGO2 cleaves passenger strand of duplex siRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464877" ], "products": [ "species_10496953" ], "modifiers": [ [ "species_10464877", "catalyst" ] ], "additional_components": [ "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739" ] }, "reaction_10472623": { "compartment": "compartment_70101", "id": "reaction_10472623", "reactome": "R-DME-5578712", "name": "Importin-8 binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443060", "species_10472619" ], "products": [ "species_10472621" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "FBgn0026252", "Q9VSD6", "FBgn0026252", "Q32KD4", "FBgn0262739" ] }, "reaction_10472637": { "compartment": "compartment_70101", "id": "reaction_10472637", "reactome": "R-DME-5578744", "name": "Importin-8 imports AGO2:miRNA into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472625", "species_10472621" ], "products": [ "species_10472631", "species_10472635" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9VZ23", "FBgn0020255", "species_29438", "Q9VSD6", "FBgn0026252", "Q32KD4", "FBgn0262739", "Q32KD4", "FBgn0262739", "Q9VSD6", "FBgn0026252", "species_29438", "Q9VZ23", "FBgn0020255", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10472668": { "compartment": "compartment_70101", "id": "reaction_10472668", "reactome": "R-DME-5578966", "name": "TNRC6A:AGO2:miRNA is transported into the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472660" ], "products": [ "species_10472666" ], "modifiers": [], "additional_components": [ "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739" ] }, "reaction_10472662": { "compartment": "compartment_70101", "id": "reaction_10472662", "reactome": "R-DME-5578965", "name": "TNRC6A binds AGO2:miRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443060", "species_10448348" ], "products": [ "species_10472660" ], "modifiers": [], "additional_components": [ "Q32KD4", "FBgn0262739", "FBgn0051992", "Q8SY33", "FBgn0051992", "Q32KD4", "FBgn0262739" ] }, "reaction_10458332": { "compartment": "compartment_70101", "id": "reaction_10458332", "reactome": "R-DME-1247960", "name": "Activation of p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10458319" ], "products": [ "species_29370", "species_10458329" ], "modifiers": [ [ "species_10450887", "catalyst" ] ], "additional_components": [ "FBgn0261524" ] }, "reaction_10433309": { "compartment": "compartment_7660", "id": "reaction_10433309", "reactome": "R-DME-77615", "name": "Deamination at C6 position of adenosine in Editosome (ADAR2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10433302" ], "products": [ "species_76230", "species_10433306" ], "modifiers": [ [ "species_10433300", "catalyst" ] ], "additional_components": [ "Q9NII1", "FBgn0026086", "Q9NII1", "FBgn0026086", "Q9NII1", "FBgn0026086" ] }, "reaction_10465775": { "compartment": "compartment_876", "id": "reaction_10465775", "reactome": "R-DME-2424477", "name": "SOS mediated nucleotide exchange of RAS (SHC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10465772", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_209218": { "compartment": "compartment_7660", "id": "reaction_209218", "reactome": "R-DME-209218", "name": "Phosphorylated DL/DIF dimer activates transcription", "reversible": "false", "notes": "In the nucleus, phosphorylated Dorsal/Dif (DL/DIF) homodimer binds to its target genes and activates transcription.", "reactants": [ "species_214725" ], "products": [ "species_214725" ], "modifiers": [], "additional_components": [ "P15330", "dl", "P98149", "Dif", "P15330", "dl", "P98149", "Dif" ] }, "reaction_209295": { "compartment": "compartment_13231", "id": "reaction_209295", "reactome": "R-DME-209295", "name": "Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated Dorsal/Dif (DL/DIF) homodimer, now free from its cytoplasmic anchor, Cactus (CACT), is imported to the nucleus. Phosphorylation of the DL/DIF homodimer is important for its nuclear localisation.", "reactants": [ "species_214728" ], "products": [ "species_214725" ], "modifiers": [], "additional_components": [ "P15330", "dl", "P98149", "Dif", "P15330", "dl", "P98149", "Dif" ] }, "reaction_209072": { "compartment": "compartment_70101", "id": "reaction_209072", "reactome": "R-DME-209072", "name": "PLL kinase binds to TL:MYD88:TUB 'signalling complex'", "reversible": "false", "notes": "The Ser/Thr kinase Pelle (PLL) binds to the death domain of Tube (TUB) in the 'signalling complex' at the plasma membrane. On binding to TUB, PLL is activated.", "reactants": [ "species_206600", "species_206070" ], "products": [ "species_206889" ], "modifiers": [], "additional_components": [ "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214878": { "compartment": "compartment_70101", "id": "reaction_214878", "reactome": "R-DME-214878", "name": "PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex'", "reversible": "false", "notes": "The Ser/Thr kinase Pelle (PLL) binds to the death domain of Tube (TUB) in the 'signalling complex' at the plasma membrane. On binding to TUB, PLL is activated.", "reactants": [ "species_206070", "species_214743" ], "products": [ "species_214742" ], "modifiers": [], "additional_components": [ "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_10436619": { "compartment": "compartment_7660", "id": "reaction_10436619", "reactome": "R-DME-163670", "name": "Nuclear transport of pChREBP (Thr 666) protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436615" ], "products": [ "species_10436617" ], "modifiers": [], "additional_components": [ "FBgn0032940", "FBgn0032940" ] }, "reaction_10436721": { "compartment": "compartment_70101", "id": "reaction_10436721", "reactome": "R-DME-164423", "name": "PhosphoChREBP (Thr 666) is exported to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436617" ], "products": [ "species_10436615" ], "modifiers": [], "additional_components": [ "FBgn0032940", "FBgn0032940" ] }, "reaction_10477549": { "compartment": "compartment_161320", "id": "reaction_10477549", "reactome": "R-DME-5690046", "name": "PPT2 hydrolyses PALMCoA to PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690537", "species_1605715" ], "products": [ "species_1678675", "species_5690516" ], "modifiers": [ [ "species_10477546", "catalyst" ] ], "additional_components": [ "FBgn0032358" ] }, "reaction_10432490": { "compartment": "compartment_70101", "id": "reaction_10432490", "reactome": "R-DME-75872", "name": "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_76183", "species_29364", "species_29508" ], "products": [ "species_29356", "species_113528", "species_29366", "species_3632881", "species_76194" ], "modifiers": [ [ "species_10432487", "catalyst" ] ], "additional_components": [ "B7Z001", "FBgn0283427" ] }, "reaction_10477738": { "compartment": "compartment_12045", "id": "reaction_10477738", "reactome": "R-DME-5690565", "name": "SCD desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10477735", "catalyst" ] ], "additional_components": [ "Q7K4Y0", "FBgn0086687" ] }, "reaction_10432425": { "compartment": "compartment_70101", "id": "reaction_10432425", "reactome": "R-DME-75849", "name": "Transport of Citrate from Mitochondrial Matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654", "species_198498" ], "products": [ "species_76190", "species_113544" ], "modifiers": [ [ "species_10432422", "catalyst" ] ], "additional_components": [ "FBgn0037912" ] }, "reaction_10441352": { "compartment": "compartment_70101", "id": "reaction_10441352", "reactome": "R-DME-200555", "name": "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10432436", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "FBgn0033246" ] }, "reaction_10441469": { "compartment": "compartment_70101", "id": "reaction_10441469", "reactome": "R-DME-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_3632881", "species_76194" ], "products": [ "species_111294", "species_29356", "species_200993", "species_76577" ], "modifiers": [ [ "species_10441466", "catalyst" ] ], "additional_components": [ "FBgn0036821" ] }, "reaction_10476157": { "compartment": "compartment_12045", "id": "reaction_10476157", "reactome": "R-DME-5676637", "name": "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676631" ], "products": [ "species_29356", "species_5676634" ], "modifiers": [ [ "species_10476154", "catalyst" ] ], "additional_components": [ "Q9VKD2", "FBgn0032394" ] }, "reaction_10453291": { "compartment": "compartment_70101", "id": "reaction_10453291", "reactome": "R-DME-548800", "name": "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_29508" ], "products": [ "species_113528", "species_548816", "species_76194" ], "modifiers": [ [ "species_10453288", "catalyst" ] ], "additional_components": [ "Q9VV87", "FBgn0260960", "Q9VHX7", "FBgn0037534", "Q6NN18", "FBgn0034382", "Q9VCY6", "FBgn0038986", "Q9VH59", "FBgn0037761", "Q4V3H4", "FBgn0037764", "Q9VCY5", "FBgn0053110", "Q9VH58", "FBgn0037762", "A1ZBD2", "FBgn0034383", "Q9VCT3", "FBgn0039030", "Q9VH57", "FBgn0037763", "Q95T98", "FBgn0051523", "Q9VH55", "FBgn0037765", "Q8SXD1", "FBgn0050008", "Q9VCZ0", "FBgn0038983", "Q8IMY2", "FBgn0051141", "Q9VCY7", "FBgn0260942" ] }, "reaction_10479066": { "compartment": "compartment_70101", "id": "reaction_10479066", "reactome": "R-DME-5695957", "name": "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5695985", "species_76194" ], "products": [ "species_111294", "species_5695971", "species_76577" ], "modifiers": [ [ "species_10479063", "catalyst" ] ], "additional_components": [ "Q9V3S9", "FBgn0027348", "Q9V3U0", "FBgn0286723" ] }, "reaction_10479082": { "compartment": "compartment_5460", "id": "reaction_10479082", "reactome": "R-DME-5696007", "name": "ACSF3 ligates CoA-SH to VLCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_5696008", "species_113593" ], "products": [ "species_159448", "species_159450", "species_5696003" ], "modifiers": [ [ "species_10479079", "catalyst" ] ], "additional_components": [ "FBgn0029945" ] }, "reaction_10453338": { "compartment": "compartment_70101", "id": "reaction_10453338", "reactome": "R-DME-548818", "name": "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548812" ], "products": [ "species_548836", "species_29366" ], "modifiers": [ [ "species_10440266", "catalyst" ] ], "additional_components": [ "FBgn0029975" ] }, "reaction_10453335": { "compartment": "compartment_70101", "id": "reaction_10453335", "reactome": "R-DME-548815", "name": "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_548794" ], "products": [ "species_113528", "species_548829", "species_76194" ], "modifiers": [ [ "species_10453327", "catalyst" ] ], "additional_components": [ "Q9VCY6", "FBgn0038986", "Q9VCY5", "FBgn0053110", "Q9VCT3", "FBgn0039030", "Q95T98", "FBgn0051523", "Q8SXD1", "FBgn0050008", "Q8IMY2", "FBgn0051141", "Q6NN18", "FBgn0034382", "Q4V3H4", "FBgn0037764", "A1ZBD2", "FBgn0034383", "Q9VHX7", "FBgn0037534", "Q9VH59", "FBgn0037761", "Q9VH58", "FBgn0037762", "Q9VH57", "FBgn0037763", "Q9VH55", "FBgn0037765", "Q9VCZ0", "FBgn0038983", "Q9VCY7", "FBgn0260942" ] }, "reaction_10453332": { "compartment": "compartment_70101", "id": "reaction_10453332", "reactome": "R-DME-548814", "name": "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29508", "species_200993" ], "products": [ "species_113528", "species_548812", "species_76194" ], "modifiers": [ [ "species_10453329", "catalyst" ] ], "additional_components": [ "Q9VCY6", "FBgn0038986", "Q9VCY5", "FBgn0053110", "Q9VCT3", "FBgn0039030", "Q95T98", "FBgn0051523", "Q8SXD1", "FBgn0050008", "Q8IMY2", "FBgn0051141", "Q6NN18", "FBgn0034382", "Q4V3H4", "FBgn0037764", "A1ZBD2", "FBgn0034383", "Q9VHX7", "FBgn0037534", "Q9VH59", "FBgn0037761", "Q9VH58", "FBgn0037762", "Q9VH57", "FBgn0037763", "Q9VH55", "FBgn0037765", "Q9VCZ0", "FBgn0038983", "Q9VCY7", "FBgn0260942", "Q9VV87", "FBgn0260960" ] }, "reaction_10453348": { "compartment": "compartment_70101", "id": "reaction_10453348", "reactome": "R-DME-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_548809" ], "products": [ "species_428139", "species_29366" ], "modifiers": [ [ "species_10453343", "catalyst" ] ], "additional_components": [ "FBgn0035471" ] }, "reaction_10436643": { "compartment": "compartment_70101", "id": "reaction_10436643", "reactome": "R-DME-163756", "name": "Formation of fatty acid synthase (FAS) dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432485" ], "products": [ "species_10432487" ], "modifiers": [], "additional_components": [ "FBgn0283427", "B7Z001", "FBgn0283427" ] }, "reaction_10495309": { "compartment": "compartment_5460", "id": "reaction_10495309", "reactome": "R-DME-8957389", "name": "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8957387" ], "products": [ "species_8957386", "species_113521" ], "modifiers": [ [ "species_10495306", "catalyst" ] ], "additional_components": [ "FBgn0038425" ] }, "reaction_10432417": { "compartment": "compartment_70101", "id": "reaction_10432417", "reactome": "R-DME-75848", "name": "ACLY tetramer transforms CIT to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_113592", "species_76194" ], "products": [ "species_29372", "species_29370", "species_76183", "species_76213" ], "modifiers": [ [ "species_10432414", "catalyst" ] ], "additional_components": [ "Q7KN85", "FBgn0020236" ] }, "reaction_10487694": { "compartment": "compartment_12045", "id": "reaction_10487694", "reactome": "R-DME-8847579", "name": "SCD5 desaturates ST-CoA to OLE-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428139", "species_70106", "species_4085415", "species_29368" ], "products": [ "species_4085425", "species_29356", "species_5690558" ], "modifiers": [ [ "species_10487691", "catalyst" ] ], "additional_components": [ "Q9VG68", "FBgn0043043", "Q9VA93", "FBgn0039755", "Q9VTD4", "FBgn0029172", "Q9VA94", "FBgn0039754", "Q7K4Y0", "FBgn0086687", "Q9VFX5", "FBgn0038130", "Q9VA92", "FBgn0039756" ] }, "reaction_10477728": { "compartment": "compartment_161320", "id": "reaction_10477728", "reactome": "R-DME-5690517", "name": "PPT1 hydrolyses palmitoylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_5690533" ], "products": [ "species_6785219", "species_5690516" ], "modifiers": [ [ "species_10477725", "catalyst" ] ], "additional_components": [ "species_3632881", "species_6785219", "FBgn0030057" ] }, "reaction_10495043": { "compartment": "compartment_17947", "id": "reaction_10495043", "reactome": "R-DME-8953946", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495031" ], "products": [ "species_10427563", "species_10495040" ], "modifiers": [ [ "species_10495031", "catalyst" ] ], "additional_components": [ "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609" ] }, "reaction_10495033": { "compartment": "compartment_17947", "id": "reaction_10495033", "reactome": "R-DME-8953917", "name": "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495029", "species_10495027" ], "products": [ "species_10495031" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609" ] }, "reaction_10493243": { "compartment": "compartment_7660", "id": "reaction_10493243", "reactome": "R-DME-8942099", "name": "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434753", "species_10467826", "species_10493239", "species_10493237", "species_10493232" ], "products": [ "species_10493241" ], "modifiers": [], "additional_components": [ "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "FBgn0001198", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0030812", "Q9VRP9", "FBgn0086694", "Q9VRP9", "FBgn0086694", "Q9VX88", "FBgn0030812", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P02283", "FBgn0001198", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637" ] }, "reaction_10493246": { "compartment": "compartment_7660", "id": "reaction_10493246", "reactome": "R-DME-8942101", "name": "RNF20:RNF40 monoubiquitinates Histone H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493241" ], "products": [ "species_10434753", "species_10488716", "species_10477560", "species_10493237", "species_10493232" ], "modifiers": [ [ "species_10493241", "catalyst" ] ], "additional_components": [ "Q9VRP9", "FBgn0086694", "Q9VX88", "FBgn0030812", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P02283", "FBgn0001198", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "FBgn0004436", "FBgn0001198", "FBgn0030812", "Q9VRP9", "FBgn0086694", "Q9VRP9", "FBgn0086694", "Q9VX88", "FBgn0030812", "P25153", "FBgn0004436", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P02283", "FBgn0001198", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637" ] }, "reaction_10433263": { "compartment": "compartment_7660", "id": "reaction_10433263", "reactome": "R-DME-77585", "name": "Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433237", "species_10433259" ], "products": [ "species_10433261" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186" ] }, "reaction_10433239": { "compartment": "compartment_7660", "id": "reaction_10433239", "reactome": "R-DME-77584", "name": "Binding of SLBP to Replication-Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433235", "species_10433230" ], "products": [ "species_10433237" ], "modifiers": [], "additional_components": [ "FBgn0041186", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186" ] }, "reaction_10433267": { "compartment": "compartment_7660", "id": "reaction_10433267", "reactome": "R-DME-77586", "name": "Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433261" ], "products": [ "species_10433265", "species_10433259" ], "modifiers": [], "additional_components": [ "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VAN6", "FBgn0041186", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554" ] }, "reaction_10436095": { "compartment": "compartment_12045", "id": "reaction_10436095", "reactome": "R-DME-162821", "name": "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855667" ], "products": [ "species_8855656", "species_162872" ], "modifiers": [ [ "species_10436092", "catalyst" ] ], "additional_components": [ "FBgn0035464" ] }, "reaction_10436079": { "compartment": "compartment_12045", "id": "reaction_10436079", "reactome": "R-DME-162797", "name": "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855656", "species_449229" ], "products": [ "species_8855664" ], "modifiers": [ [ "species_10436076", "catalyst" ] ], "additional_components": [ "FBgn0266438" ] }, "reaction_10436056": { "compartment": "compartment_70101", "id": "reaction_10436056", "reactome": "R-DME-162730", "name": "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_162756" ], "products": [ "species_8855657", "species_110096" ], "modifiers": [ [ "species_10436053", "catalyst" ] ], "additional_components": [ "E1JIA5", "FBgn0259933", "Q7JUM3", "FBgn0034270", "Q8MSE4", "FBgn0039405", "Q9VHX6", "FBgn0037535", "A0A2U8U156", "FBgn0035435", "Q8IR17", "FBgn0086448" ] }, "reaction_10436087": { "compartment": "compartment_12045", "id": "reaction_10436087", "reactome": "R-DME-162798", "name": "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855659", "species_1500581" ], "products": [ "species_8855663", "species_1500596" ], "modifiers": [ [ "species_10436084", "catalyst" ] ], "additional_components": [ "FBgn0033479" ] }, "reaction_10436103": { "compartment": "compartment_12045", "id": "reaction_10436103", "reactome": "R-DME-162873", "name": "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_8855663" ], "products": [ "species_162872", "species_8855667" ], "modifiers": [ [ "species_10436100", "catalyst" ] ], "additional_components": [ "FBgn0265174" ] }, "reaction_10436071": { "compartment": "compartment_12045", "id": "reaction_10436071", "reactome": "R-DME-162742", "name": "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855660" ], "products": [ "species_8855660" ], "modifiers": [ [ "species_10436068", "catalyst" ] ], "additional_components": [ "Q9VW21", "FBgn0036893", "A1Z705", "FBgn0033187" ] }, "reaction_10436004": { "compartment": "compartment_17957", "id": "reaction_10436004", "reactome": "R-DME-162683", "name": "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_8855661" ], "products": [ "species_8855666", "species_76194" ], "modifiers": [ [ "species_10436001", "catalyst" ] ], "additional_components": [ "FBgn0035265" ] }, "reaction_10467548": { "compartment": "compartment_70101", "id": "reaction_10467548", "reactome": "R-DME-3134962", "name": "DHX36 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467524", "species_3134861" ], "products": [ "species_10467526" ], "modifiers": [], "additional_components": [ "FBgn0032883", "Q8SWT2", "FBgn0032883" ] }, "reaction_10497380": { "compartment": "compartment_70101", "id": "reaction_10497380", "reactome": "R-DME-9604480", "name": "NFkB complex translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437411" ], "products": [ "species_10437455" ], "modifiers": [ [ "species_10467540", "catalyst" ] ], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P24785", "FBgn0002774", "Q7K105", "MYD88" ] }, "reaction_10467546": { "compartment": "compartment_70101", "id": "reaction_10467546", "reactome": "R-DME-3134954", "name": "DHX9 binds DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467528", "species_3134861" ], "products": [ "species_10467530" ], "modifiers": [], "additional_components": [ "FBgn0002774", "P24785", "FBgn0002774" ] }, "reaction_10467544": { "compartment": "compartment_70101", "id": "reaction_10467544", "reactome": "R-DME-3134953", "name": "DHX36 or DHX9 binds MyD88", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467536", "species_10467532" ], "products": [ "species_10467542" ], "modifiers": [], "additional_components": [ "P24785", "FBgn0002774", "Q8SWT2", "FBgn0032883", "P24785", "FBgn0002774", "Q7K105", "MYD88", "Q8SWT2", "FBgn0032883" ] }, "reaction_209187": { "compartment": "compartment_70101", "id": "reaction_209187", "reactome": "R-DME-209187", "name": "Further phosphorylation of CI by CKIalphaepsilon", "reversible": "false", "notes": "Previous phosphorylation of Cubitus Interruptus (CI) at Ser852 and Ser888 primes further phosphorylation by CKIalphaepsilon (CKIalpha/DCO) at Ser855, Ser858, and Ser891.", "reactants": [ "species_113592", "species_206997" ], "products": [ "species_206766", "species_29370" ], "modifiers": [ [ "species_206577", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "P19538", "ci", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P19538", "ci", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "O76324", "DCO" ] }, "reaction_209172": { "compartment": "compartment_70101", "id": "reaction_209172", "reactome": "R-DME-209172", "name": "Phosphorylation of CI by SGG", "reversible": "false", "notes": "Previous phosphorylation of Cubitus Interruptus (CI) at Ser856 and Ser892 primes Shaggy (SGG) phosphorylation at Ser884 and Ser888. Ser852 can also be phosphorylated by SGG if it hasn't been previously phosphorylated by CKIalpha/DCO.", "reactants": [ "species_206924", "species_113592" ], "products": [ "species_29370", "species_206997" ], "modifiers": [ [ "species_206898", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "P19538", "ci", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "P91667", "Phospho (5 sites) APC", "Q9Y1T2", "Apc2", "O76324", "DCO", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn" ] }, "reaction_209293": { "compartment": "compartment_70101", "id": "reaction_209293", "reactome": "R-DME-209293", "name": "Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO)", "reversible": "false", "notes": "The priming phosphorylations of Cubitus Interruptus (CI) results in additional phosphorylation by kinases CKIalphaepsilon (CKIalpha/DCO) at Ser841, Ser844, Thr845, Ser849, Ser852, Ser859, Ser862, and Ser895.", "reactants": [ "species_113592", "species_206916" ], "products": [ "species_206924", "species_29370" ], "modifiers": [ [ "species_206577", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "P19538", "ci", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "O76324", "DCO" ] }, "reaction_209196": { "compartment": "compartment_70101", "id": "reaction_209196", "reactome": "R-DME-209196", "name": "Phosphorylation of CI by PKA-C1", "reversible": "false", "notes": "Cubitus Interruptus (CI) is primed for phosphorylation by Protein kinase A (PKA-C1) at Ser838, Ser856, and Ser892.", "reactants": [ "species_113592", "species_206721" ], "products": [ "species_29370", "species_206916" ], "modifiers": [ [ "species_206865", "catalyst" ] ], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "P19538", "ci", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "Q24170", "Phospho KSR", "P11346", "Raf", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "Q7KNQ9", "cnk", "Q8ML92", "AVE", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10457576": { "compartment": "compartment_7660", "id": "reaction_10457576", "reactome": "R-DME-997326", "name": "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10454153" ], "products": [ "species_113550", "species_10457569" ], "modifiers": [ [ "species_10457573", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10448751": { "compartment": "compartment_70101", "id": "reaction_10448751", "reactome": "R-DME-428917", "name": "G13 activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10448746" ], "products": [ "species_29420", "species_10448748" ], "modifiers": [ [ "species_10448746", "catalyst" ] ], "additional_components": [ "CHEBI:15627", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "CHEBI:15627", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P25157", "FBgn0000384", "species_29438", "CHEBI:15627", "P25157", "FBgn0000384", "species_29420", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10448722": { "compartment": "compartment_70101", "id": "reaction_10448722", "reactome": "R-DME-428750", "name": "Gq activation by TP receptor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10448717" ], "products": [ "species_29420", "species_10448719" ], "modifiers": [ [ "species_10448717", "catalyst" ] ], "additional_components": [ "CHEBI:15627", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "CHEBI:15627", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "CHEBI:15627", "species_29420", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10446811": { "compartment": "compartment_70101", "id": "reaction_10446811", "reactome": "R-DME-392195", "name": "Gi activation by P2Y purinoceptor 12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10446806" ], "products": [ "species_29420", "species_10446808" ], "modifiers": [ [ "species_10446806", "catalyst" ] ], "additional_components": [ "species_29370", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "P20353", "FBgn0001104", "species_29438", "P26308", "FBgn0001105", "P38040", "FBgn0004921", "species_29370", "species_29370", "species_29420", "P20353", "FBgn0001104", "P26308", "FBgn0001105", "P38040", "FBgn0004921" ] }, "reaction_10448755": { "compartment": "compartment_70101", "id": "reaction_10448755", "reactome": "R-DME-428941", "name": "P2Y purinoceptor 1 activates MAP kinase p38 alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448753", "species_113592" ], "products": [ "species_29370", "species_10439430" ], "modifiers": [ [ "species_10434217", "catalyst" ] ], "additional_components": [ "FBgn0024846", "FBgn0024846", "P23625", "FBgn0004435", "Q8MQV5", "FBgn0050054", "Q0E9A7", "FBgn0050054", "species_29438" ] }, "reaction_10447584": { "compartment": "compartment_70101", "id": "reaction_10447584", "reactome": "R-DME-418662", "name": "Src activation following P2Y purinoceptor activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440003" ], "products": [ "species_10447582" ], "modifiers": [], "additional_components": [ "FBgn0262733", "FBgn0262733" ] }, "reaction_10433304": { "compartment": "compartment_7660", "id": "reaction_10433304", "reactome": "R-DME-77613", "name": "Binding of ADAR2 homodimer to dsRNA duplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75086", "species_10433300" ], "products": [ "species_10433302" ], "modifiers": [], "additional_components": [ "Q9NII1", "FBgn0026086", "Q9NII1", "FBgn0026086" ] }, "reaction_10434102": { "compartment": "compartment_7660", "id": "reaction_10434102", "reactome": "R-DME-111238", "name": "Formation of ADAR2 homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433298" ], "products": [ "species_10433300" ], "modifiers": [], "additional_components": [ "FBgn0026086", "Q9NII1", "FBgn0026086" ] }, "reaction_10455818": { "compartment": "compartment_20699", "id": "reaction_10455818", "reactome": "R-DME-975829", "name": "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975819" ], "products": [ "species_205687", "species_975822" ], "modifiers": [ [ "species_10455815", "catalyst" ] ], "additional_components": [ "FBgn0039738" ] }, "reaction_10479784": { "compartment": "compartment_20699", "id": "reaction_10479784", "reactome": "R-DME-6786048", "name": "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_6786371" ], "products": [ "species_742343", "species_6786380" ], "modifiers": [ [ "species_10479781", "catalyst" ] ], "additional_components": [ "Q8IRG5", "FBgn0035287", "Q9VMS3", "FBgn0031697", "Q9VJG5", "FBgn0032618" ] }, "reaction_10457715": { "compartment": "compartment_20699", "id": "reaction_10457715", "reactome": "R-DME-1028788", "name": "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975910", "species_205683" ], "products": [ "species_205689", "species_1028779" ], "modifiers": [ [ "species_10457712", "catalyst" ] ], "additional_components": [ "FBgn0030327" ] }, "reaction_10478179": { "compartment": "compartment_161320", "id": "reaction_10478179", "reactome": "R-DME-5693807", "name": "FUCA1 hydrolyses NGP:1,6-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_6784247" ], "products": [ "species_6784248", "species_6784249" ], "modifiers": [ [ "species_10478176", "catalyst" ] ], "additional_components": [ "Q9VTJ4", "FBgn0285958" ] }, "reaction_10455810": { "compartment": "compartment_20699", "id": "reaction_10455810", "reactome": "R-DME-975814", "name": "Trimming of mannoses on the alpha1,6 arm by MAN2A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964837" ], "products": [ "species_964752", "species_975819" ], "modifiers": [ [ "species_10455807", "catalyst" ] ], "additional_components": [ "Q9VF33", "FBgn0026616", "species_1562550", "Q24451", "FBgn0011740" ] }, "reaction_10455908": { "compartment": "compartment_17963", "id": "reaction_10455908", "reactome": "R-DME-975926", "name": "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_975910" ], "products": [ "species_981613" ], "modifiers": [ [ "species_10455905", "catalyst" ] ], "additional_components": [ "FBgn0051849" ] }, "reaction_10440636": { "compartment": "compartment_70101", "id": "reaction_10440636", "reactome": "R-DME-196350", "name": "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_29360" ], "products": [ "species_70106", "species_196344", "species_73473" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10440208": { "compartment": "compartment_70101", "id": "reaction_10440208", "reactome": "R-DME-193052", "name": "Pregn-5-ene-3,20-dione isomerizes to progesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196344" ], "products": [ "species_193055" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10493825": { "compartment": "compartment_7660", "id": "reaction_10493825", "reactome": "R-DME-8952058", "name": "CCND1 binds RUNX3 and displaces EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493737", "species_10457979" ], "products": [ "species_10493823", "species_10458126" ], "modifiers": [], "additional_components": [ "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "FBgn0010315", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "FBgn0261617" ] }, "reaction_10493829": { "compartment": "compartment_7660", "id": "reaction_10493829", "reactome": "R-DME-8952062", "name": "CCND1 recruits HDAC4 to RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493823", "species_10469978" ], "products": [ "species_10493827" ], "modifiers": [], "additional_components": [ "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "FBgn0041210", "M9PHQ2", "FBgn0041210", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656" ] }, "reaction_10493721": { "compartment": "compartment_7660", "id": "reaction_10493721", "reactome": "R-DME-8951966", "name": "EP300 acetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493708", "species_113560" ], "products": [ "species_2485002", "species_10493718" ], "modifiers": [ [ "species_10493708", "catalyst" ], [ "species_10437860", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10493834": { "compartment": "compartment_7660", "id": "reaction_10493834", "reactome": "R-DME-8952069", "name": "HDAC4 deacetylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10493827" ], "products": [ "species_427486", "species_10493735", "species_10493831" ], "modifiers": [ [ "species_10493827", "catalyst" ] ], "additional_components": [ "M9PHQ2", "FBgn0041210", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "Q7KUZ5", "FBgn0010315", "M9PHQ2", "FBgn0041210", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "M9PHQ2", "FBgn0041210", "Q7KUZ5", "FBgn0010315", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656" ] }, "reaction_10493739": { "compartment": "compartment_7660", "id": "reaction_10493739", "reactome": "R-DME-8951977", "name": "Acetylated RUNX3 binds to BRD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493735", "species_10493718" ], "products": [ "species_10493737" ], "modifiers": [ [ "species_206703", "catalyst" ] ], "additional_components": [ "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "Q24040", "FBgn0013753", "Q9VCG6", "FBgn0039124", "P13709", "FBgn0004656", "P08646", "RAS85D", "species_29438" ] }, "reaction_10493710": { "compartment": "compartment_7660", "id": "reaction_10493710", "reactome": "R-DME-8951951", "name": "RUNX3 binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489803", "species_10458126" ], "products": [ "species_10493708" ], "modifiers": [], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "FBgn0261617", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981" ] }, "reaction_10449032": { "compartment": "compartment_70101", "id": "reaction_10449032", "reactome": "R-DME-429961", "name": "DCPS scavenges the 7-methylguanosine cap of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429926" ], "products": [ "species_430042", "species_429925" ], "modifiers": [ [ "species_10449029", "catalyst" ] ], "additional_components": [ "FBgn0037372" ] }, "reaction_10478392": { "compartment": "compartment_70101", "id": "reaction_10478392", "reactome": "R-DME-5694126", "name": "NT5C3B hydrolyses 7MGP to 7MG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_430042" ], "products": [ "species_29372", "species_5694090" ], "modifiers": [ [ "species_10478389", "catalyst" ] ], "additional_components": [ "FBgn0034988" ] }, "reaction_10449126": { "compartment": "compartment_70101", "id": "reaction_10449126", "reactome": "R-DME-430028", "name": "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_429974" ], "products": [ "species_109402", "species_113578", "species_109395", "species_429926", "species_76577" ], "modifiers": [ [ "species_10449123", "catalyst" ] ], "additional_components": [ "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9XZ19", "FBgn0027524", "Q6NNB2", "FBgn0033376", "Q9VCH8", "FBgn0039117", "Q9W074", "FBgn0042712" ] }, "reaction_10492020": { "compartment": "compartment_7660", "id": "reaction_10492020", "reactome": "R-DME-8934735", "name": "PRMT1 arginine-methylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10491997" ], "products": [ "species_77502", "species_10492017" ], "modifiers": [ [ "species_10491997", "catalyst" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834" ] }, "reaction_10492022": { "compartment": "compartment_7660", "id": "reaction_10492022", "reactome": "R-DME-8934742", "name": "RUNX1 binds PRMT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467587", "species_10489794" ], "products": [ "species_10491997" ], "modifiers": [], "additional_components": [ "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834" ] }, "reaction_10492150": { "compartment": "compartment_7660", "id": "reaction_10492150", "reactome": "R-DME-8936481", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492130" ], "products": [ "species_77502", "species_10492147" ], "modifiers": [ [ "species_10492130", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10492198": { "compartment": "compartment_7660", "id": "reaction_10492198", "reactome": "R-DME-8937050", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492193" ], "products": [ "species_77502", "species_10492195" ], "modifiers": [ [ "species_10492193", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10492189": { "compartment": "compartment_7660", "id": "reaction_10492189", "reactome": "R-DME-8937016", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492184" ], "products": [ "species_77502", "species_10492186" ], "modifiers": [ [ "species_10492184", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10492159": { "compartment": "compartment_7660", "id": "reaction_10492159", "reactome": "R-DME-8936621", "name": "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10492154" ], "products": [ "species_77502", "species_10492156" ], "modifiers": [ [ "species_10492154", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199", "M9MS40", "FBgn0261617", "Q24040", "FBgn0013753", "Q9VGW7", "FBgn0037834", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VTZ1", "FBgn0020388", "P91623", "FBgn0001138", "Q9VPQ6", "FBgn0003963", "Q9V3J8", "FBgn0040066", "Q9VPH8", "FBgn0036973", "P20659", "FBgn0003862", "Q5LJZ2", "FBgn0040022", "Q9VUB5", "FBgn0036398", "Q8IRW8", "FBgn0023518", "Q9W1H0", "FBgn0263667", "Q94545", "FBgn0000139", "Q9VZJ1", "FBgn0035491", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "P02299", "FBgn0001199" ] }, "reaction_10468106": { "compartment": "compartment_70101", "id": "reaction_10468106", "reactome": "R-DME-3249379", "name": "p-S407-STAT6 is phosphorylated at Tyr641", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468104" ], "products": [ "species_29370", "species_10468092" ], "modifiers": [], "additional_components": [] }, "reaction_10468102": { "compartment": "compartment_70101", "id": "reaction_10468102", "reactome": "R-DME-3249372", "name": "p-S407,Y641-STAT6 is dimerized", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468092" ], "products": [ "species_10468094" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10468100": { "compartment": "compartment_70101", "id": "reaction_10468100", "reactome": "R-DME-3249370", "name": "p-S407,Y641-STAT6 dimer migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468094" ], "products": [ "species_10468098" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10430845": { "compartment": "compartment_70101", "id": "reaction_10430845", "reactome": "R-DME-72697", "name": "Start codon recognition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430513", "species_72617", "species_10430440", "species_10430457", "species_10430508" ], "products": [ "species_10430513", "species_72617", "species_10430440", "species_10430457", "species_10430508" ], "modifiers": [ [ "species_72617", "catalyst" ] ], "additional_components": [ "FBgn0030719", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0030719", "FBgn0026250", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10430519": { "compartment": "compartment_70101", "id": "reaction_10430519", "reactome": "R-DME-72621", "name": "Ribosomal scanning ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430508" ], "products": [ "species_29372", "species_29370", "species_10430508" ], "modifiers": [ [ "species_72617", "catalyst" ], [ "species_113592", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10464559": { "compartment": "compartment_7660", "id": "reaction_10464559", "reactome": "R-DME-2032794", "name": "WWTR1 (TAZ), TBX5, and PCAF form a complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464550", "species_10464555", "species_10464523" ], "products": [ "species_10464557" ], "modifiers": [], "additional_components": [ "FBgn0020388", "FBgn0021767", "Q9W3F4", "FBgn0021767", "Q45VV3", "yki", "Q9VTZ1", "FBgn0020388" ] }, "reaction_10490929": { "compartment": "compartment_7660", "id": "reaction_10490929", "reactome": "R-DME-8871260", "name": "YAP1 binds TEAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10464537" ], "products": [ "species_10490927" ], "modifiers": [], "additional_components": [ "P30052", "sd", "Q45VV3", "yki" ] }, "reaction_10490933": { "compartment": "compartment_7660", "id": "reaction_10490933", "reactome": "R-DME-8871265", "name": "YAP1 binds TEAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10464541" ], "products": [ "species_10490931" ], "modifiers": [], "additional_components": [ "P30052", "sd", "Q45VV3", "yki" ] }, "reaction_10464535": { "compartment": "compartment_7660", "id": "reaction_10464535", "reactome": "R-DME-2032775", "name": "YAP1 binds TEAD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464531", "species_10458548" ], "products": [ "species_10464533" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_10490937": { "compartment": "compartment_7660", "id": "reaction_10490937", "reactome": "R-DME-8871266", "name": "YAP1 binds TEAD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10464539" ], "products": [ "species_10490935" ], "modifiers": [], "additional_components": [ "P30052", "sd", "Q45VV3", "yki" ] }, "reaction_10464545": { "compartment": "compartment_7660", "id": "reaction_10464545", "reactome": "R-DME-2032781", "name": "WWTR1 (TAZ) binds TEAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464531", "species_10464523" ], "products": [ "species_10464543" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_10440633": { "compartment": "compartment_70101", "id": "reaction_10440633", "reactome": "R-DME-196060", "name": "Reduction of isocaproaldehyde to 4-methylpentan-1-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196095", "species_70106", "species_29364" ], "products": [ "species_29366", "species_196066" ], "modifiers": [ [ "species_10440630", "catalyst" ] ], "additional_components": [ "FBgn0086254" ] }, "reaction_10433192": { "compartment": "compartment_5460", "id": "reaction_10433192", "reactome": "R-DME-77314", "name": "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77313", "species_113521" ], "products": [ "species_77251" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433202": { "compartment": "compartment_5460", "id": "reaction_10433202", "reactome": "R-DME-77319", "name": "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77318" ], "products": [ "species_31649", "species_77313" ], "modifiers": [ [ "species_10433199", "catalyst" ] ], "additional_components": [ "Q9VDT1", "FBgn0038742" ] }, "reaction_10435438": { "compartment": "compartment_17951", "id": "reaction_10435438", "reactome": "R-DME-141348", "name": "PAO:FAD oxidises NASPM to PTCN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141349" ], "products": [ "species_141327", "species_113575", "species_141350" ], "modifiers": [ [ "species_10435435", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VHN8", "FBgn0037606" ] }, "reaction_10435428": { "compartment": "compartment_17951", "id": "reaction_10435428", "reactome": "R-DME-141341", "name": "SMOX-3 oxidises SPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141342" ], "products": [ "species_141324", "species_113575", "species_141328" ], "modifiers": [ [ "species_10435425", "catalyst" ] ], "additional_components": [ "FBgn0036749" ] }, "reaction_10444066": { "compartment": "compartment_70101", "id": "reaction_10444066", "reactome": "R-DME-351208", "name": "Spermidine => N-acetylated spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_76183" ], "products": [ "species_353555", "species_76194" ], "modifiers": [ [ "species_10444061", "catalyst" ] ], "additional_components": [ "FBgn0038302" ] }, "reaction_10444064": { "compartment": "compartment_70101", "id": "reaction_10444064", "reactome": "R-DME-351207", "name": "Spermine => N-acetylated spermine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353560", "species_76183" ], "products": [ "species_76194", "species_353575" ], "modifiers": [ [ "species_10444061", "catalyst" ] ], "additional_components": [ "FBgn0038302" ] }, "reaction_10435440": { "compartment": "compartment_17951", "id": "reaction_10435440", "reactome": "R-DME-141351", "name": "PAOX:FAD oxidises NASPN to SPM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_141323" ], "products": [ "species_141324", "species_141327", "species_113575" ], "modifiers": [ [ "species_10435435", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VHN8", "FBgn0037606" ] }, "reaction_10454399": { "compartment": "compartment_70101", "id": "reaction_10454399", "reactome": "R-DME-893596", "name": "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29970" ], "products": [ "species_29432", "species_893615" ], "modifiers": [ [ "species_10454393", "catalyst" ], [ "species_29502", "inhibitor" ], [ "species_8939576", "inhibitor" ] ], "additional_components": [ "Q8SXC2", "FBgn0037955", "CHEBI:55528", "CHEBI:43580" ] }, "reaction_10490481": { "compartment": "compartment_876", "id": "reaction_10490481", "reactome": "R-DME-8870352", "name": "SLC36A4 transports L-Trp from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352006" ], "products": [ "species_29500" ], "modifiers": [ [ "species_10490478", "catalyst" ] ], "additional_components": [ "Q8IQF3", "FBgn0052081", "Q9VLM3", "FBgn0032036", "Q9VT04", "FBgn0036007", "Q9VTD5", "FBgn0052079", "M9PEU1", "FBgn0263776", "Q9VTD7", "FBgn0036116", "M9PHT8", "FBgn0030817", "Q9VX84", "FBgn0030816", "Q4V5R4", "FBgn0033572", "Q9W056", "FBgn0035300", "Q7K2W3", "FBgn0033760" ] }, "reaction_10428730": { "compartment": "compartment_70101", "id": "reaction_10428730", "reactome": "R-DME-71188", "name": "TDO tetramer dioxygenates L-Trp to NFK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29500", "species_29368" ], "products": [ "species_33179" ], "modifiers": [ [ "species_10428727", "catalyst" ] ], "additional_components": [ "species_71185", "P20351", "FBgn0003965" ] }, "reaction_10428738": { "compartment": "compartment_70101", "id": "reaction_10428738", "reactome": "R-DME-71200", "name": "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_29970" ], "products": [ "species_34351", "species_29356", "species_29366" ], "modifiers": [ [ "species_10428735", "catalyst" ] ], "additional_components": [ "FBgn0000337" ] }, "reaction_10426991": { "compartment": "compartment_70101", "id": "reaction_10426991", "reactome": "R-DME-68712", "name": "The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10426958" ], "products": [ "species_10426956", "species_10426989" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7JVY2", "FBgn0000996", "Q7JX41", "FBgn0033081", "FBgn0000996", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7JX41", "FBgn0033081" ] }, "reaction_10427212": { "compartment": "compartment_7660", "id": "reaction_10427212", "reactome": "R-DME-68826", "name": "Free CDT1 associates with CDC6:ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426944", "species_10427208" ], "products": [ "species_10427210" ], "modifiers": [], "additional_components": [ "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "FBgn0000996", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918" ] }, "reaction_10427206": { "compartment": "compartment_70101", "id": "reaction_10427206", "reactome": "R-DME-68825", "name": "Ubiquitinated geminin is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426989" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7JX41", "FBgn0033081", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10491189": { "compartment": "compartment_17927", "id": "reaction_10491189", "reactome": "R-DME-8875838", "name": "SLC25A19 transports ThDP from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29480" ], "products": [ "species_8878387" ], "modifiers": [ [ "species_10491186", "catalyst" ] ], "additional_components": [ "FBgn0037852" ] }, "reaction_10441188": { "compartment": "compartment_876", "id": "reaction_10441188", "reactome": "R-DME-199626", "name": "SLC19A2/3 transport extracellular THMN to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_199622" ], "products": [ "species_196934" ], "modifiers": [ [ "species_10441185", "catalyst" ] ], "additional_components": [ "Q9VGV5", "FBgn0037846", "Q9VK64", "FBgn0032449", "Q9VGV6", "FBgn0037845" ] }, "reaction_10440656": { "compartment": "compartment_70101", "id": "reaction_10440656", "reactome": "R-DME-196761", "name": "2xTPK1:Mg2+ phosphorylates THMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196934" ], "products": [ "species_29480", "species_76577" ], "modifiers": [ [ "species_10440653", "catalyst" ] ], "additional_components": [ "Q8T4A5", "FBgn0037942", "species_29926" ] }, "reaction_10440685": { "compartment": "compartment_70101", "id": "reaction_10440685", "reactome": "R-DME-196929", "name": "FLAD1 phosphorylates FMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_73524" ], "products": [ "species_111294", "species_29386" ], "modifiers": [ [ "species_10440682", "catalyst" ] ], "additional_components": [ "FBgn0030431" ] }, "reaction_10467560": { "compartment": "compartment_70101", "id": "reaction_10467560", "reactome": "R-DME-3165230", "name": "SLC52A1,2,3 transport RIB from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3165253" ], "products": [ "species_196931" ], "modifiers": [ [ "species_10467553", "catalyst" ], [ "species_73524", "inhibitor" ], [ "species_29386", "inhibitor" ] ], "additional_components": [ "FBgn0039882" ] }, "reaction_10440695": { "compartment": "compartment_70101", "id": "reaction_10440695", "reactome": "R-DME-196964", "name": "RFK:Mg2+ phosphorylates RIB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196931" ], "products": [ "species_29370", "species_73524" ], "modifiers": [ [ "species_10440692", "catalyst" ] ], "additional_components": [ "species_29926", "O76206", "FBgn0014930" ] }, "reaction_10455535": { "compartment": "compartment_70101", "id": "reaction_10455535", "reactome": "R-DME-964962", "name": "2xPDKX:2xZn2+ phosphorylates PDX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965053" ], "products": [ "species_29370", "species_964952" ], "modifiers": [ [ "species_10455530", "catalyst" ] ], "additional_components": [ "species_1562550", "Q7KUC2", "FBgn0085484" ] }, "reaction_10455533": { "compartment": "compartment_70101", "id": "reaction_10455533", "reactome": "R-DME-964958", "name": "2xPDXK:2xZn2+ phosphorylates PXA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964945", "species_113592" ], "products": [ "species_29370", "species_965146" ], "modifiers": [ [ "species_10455530", "catalyst" ] ], "additional_components": [ "species_1562550", "Q7KUC2", "FBgn0085484" ] }, "reaction_10455549": { "compartment": "compartment_70101", "id": "reaction_10455549", "reactome": "R-DME-965079", "name": "2xPNPO:2xFMN oxidizes PXAP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965146" ], "products": [ "species_29390", "species_31633", "species_29408" ], "modifiers": [ [ "species_10455544", "catalyst" ] ], "additional_components": [ "species_76629", "Q9VHZ5", "FBgn0051472" ] }, "reaction_10455547": { "compartment": "compartment_70101", "id": "reaction_10455547", "reactome": "R-DME-965019", "name": "2xPNPO:2xFMN oxidizes PDXP to PXLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_964952" ], "products": [ "species_29390", "species_29408" ], "modifiers": [ [ "species_10455544", "catalyst" ] ], "additional_components": [ "species_76629", "Q9VHZ5", "FBgn0051472" ] }, "reaction_10467575": { "compartment": "compartment_70101", "id": "reaction_10467575", "reactome": "R-DME-3204311", "name": "AOX1 oxidises PXL to PDXate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29368", "species_965131" ], "products": [ "species_3204324", "species_29408" ], "modifiers": [ [ "species_10467572", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "CHEBI:44074", "species_113596", "P10351", "FBgn0003308" ] }, "reaction_10455537": { "compartment": "compartment_70101", "id": "reaction_10455537", "reactome": "R-DME-964970", "name": "2xPDXK:2xZn2+ phosphorylates PXL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_965131" ], "products": [ "species_29390", "species_29370" ], "modifiers": [ [ "species_10455530", "catalyst" ] ], "additional_components": [ "species_1562550", "Q7KUC2", "FBgn0085484" ] }, "reaction_10467320": { "compartment": "compartment_876", "id": "reaction_10467320", "reactome": "R-DME-3000103", "name": "CUBN:AMN binds GIF:Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467316", "species_10443525" ], "products": [ "species_10467318" ], "modifiers": [], "additional_components": [ "species_3000239", "Q9W4K2", "FBgn0029708", "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467416": { "compartment": "compartment_70101", "id": "reaction_10467416", "reactome": "R-DME-3095901", "name": "ABCC1 transports cytosolic Cbl to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_3000241", "species_113592" ], "products": [ "species_29372", "species_29370", "species_3000125" ], "modifiers": [ [ "species_10443830", "catalyst" ] ], "additional_components": [ "FBgn0032456" ] }, "reaction_10467352": { "compartment": "compartment_161320", "id": "reaction_10467352", "reactome": "R-DME-3000263", "name": "TCII:Cbl is degraded to release Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467328" ], "products": [ "species_3000239" ], "modifiers": [], "additional_components": [ "Q9W4K2", "FBgn0029708", "species_3000239" ] }, "reaction_10467350": { "compartment": "compartment_17940", "id": "reaction_10467350", "reactome": "R-DME-3000247", "name": "Endosomal GIF:Cbl translocates to lysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467342" ], "products": [ "species_10467348" ], "modifiers": [], "additional_components": [ "species_3000239", "Q9W4K2", "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467332": { "compartment": "compartment_984", "id": "reaction_10467332", "reactome": "R-DME-3000120", "name": "GIF binds Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467314", "species_3000125" ], "products": [ "species_10467316" ], "modifiers": [], "additional_components": [ "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467507": { "compartment": "compartment_984", "id": "reaction_10467507", "reactome": "R-DME-3132759", "name": "TCN1 binds Cbl", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3132775", "species_10467503" ], "products": [ "species_10467505", "species_3132772" ], "modifiers": [], "additional_components": [ "species_3000239", "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467891": { "compartment": "compartment_984", "id": "reaction_10467891", "reactome": "R-DME-3245898", "name": "TCN1 binds Cbl in the circulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467503", "species_3000125" ], "products": [ "species_10467505" ], "modifiers": [], "additional_components": [ "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467330": { "compartment": "compartment_17940", "id": "reaction_10467330", "reactome": "R-DME-3000112", "name": "Endosomal TCII:Cbl translocates to lysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467324" ], "products": [ "species_10467328" ], "modifiers": [], "additional_components": [ "species_3000239", "Q9W4K2", "FBgn0029708", "Q9W4K2", "FBgn0029708", "species_3000239" ] }, "reaction_10467344": { "compartment": "compartment_984", "id": "reaction_10467344", "reactome": "R-DME-3000137", "name": "CUBN:AMN transports extracellular GIF:Cbl to endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467318" ], "products": [ "species_10467338", "species_10467342" ], "modifiers": [], "additional_components": [ "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "species_3000239", "Q9W4K2", "FBgn0029708", "A8JQY3", "FBgn0085431", "Q9VPN2", "FBgn0025686", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10467312": { "compartment": "compartment_984", "id": "reaction_10467312", "reactome": "R-DME-3000074", "name": "TCII binds Cbl in the circulation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467308", "species_3000125" ], "products": [ "species_10467310" ], "modifiers": [], "additional_components": [ "FBgn0029708", "species_3000239", "Q9W4K2", "FBgn0029708" ] }, "reaction_10440735": { "compartment": "compartment_70101", "id": "reaction_10440735", "reactome": "R-DME-197271", "name": "NADSYN1 hexamer amidates NAAD to NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_197256", "species_113592", "species_29472" ], "products": [ "species_111294", "species_29404", "species_76577", "species_29360" ], "modifiers": [ [ "species_10440732", "catalyst" ] ], "additional_components": [ "Q9VYA0", "FBgn0030512" ] }, "reaction_10441342": { "compartment": "compartment_5460", "id": "reaction_10441342", "reactome": "R-DME-200474", "name": "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938083", "species_113593" ], "products": [ "species_8938078", "species_8938090" ], "modifiers": [ [ "species_10441339", "catalyst" ] ], "additional_components": [ "Q9VC03", "FBgn0039254", "species_29926" ] }, "reaction_10490435": { "compartment": "compartment_70101", "id": "reaction_10490435", "reactome": "R-DME-8869606", "name": "NMRK1 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10490432", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10490440": { "compartment": "compartment_70101", "id": "reaction_10490440", "reactome": "R-DME-8869607", "name": "NMRK2 phosphorylates NAR to yield NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869365" ], "products": [ "species_70106", "species_29370", "species_197220" ], "modifiers": [ [ "species_10490437", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10440725": { "compartment": "compartment_70101", "id": "reaction_10440725", "reactome": "R-DME-197235", "name": "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_197220" ], "products": [ "species_197256", "species_1132084" ], "modifiers": [ [ "species_10440722", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VC03", "FBgn0039254" ] }, "reaction_10490443": { "compartment": "compartment_70101", "id": "reaction_10490443", "reactome": "R-DME-8869627", "name": "NMRK2 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10490437", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10492619": { "compartment": "compartment_984", "id": "reaction_10492619", "reactome": "R-DME-8940070", "name": "NT5E:Zn2+ hydrolyses NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352330", "species_109276" ], "products": [ "species_109277", "species_8940067" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10492621": { "compartment": "compartment_984", "id": "reaction_10492621", "reactome": "R-DME-8940074", "name": "NT5E:Zn2+ hydrolyses NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8940067" ], "products": [ "species_109277", "species_8940077" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10490446": { "compartment": "compartment_70101", "id": "reaction_10490446", "reactome": "R-DME-8869633", "name": "NMRK1 phosphorylates NR to yield NMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_8869377" ], "products": [ "species_8869353", "species_70106", "species_29370" ], "modifiers": [ [ "species_10490432", "catalyst" ] ], "additional_components": [ "FBgn0035436" ] }, "reaction_10440715": { "compartment": "compartment_70101", "id": "reaction_10440715", "reactome": "R-DME-197198", "name": "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29360" ], "products": [ "species_29370", "species_29366" ], "modifiers": [ [ "species_10440712", "catalyst" ] ], "additional_components": [ "species_1562550", "Q6IDH2", "FBgn0033853" ] }, "reaction_10492564": { "compartment": "compartment_70101", "id": "reaction_10492564", "reactome": "R-DME-8939959", "name": "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869353", "species_113592" ], "products": [ "species_1132084", "species_29360" ], "modifiers": [ [ "species_10440722", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VC03", "FBgn0039254" ] }, "reaction_10486272": { "compartment": "compartment_5460", "id": "reaction_10486272", "reactome": "R-DME-6806967", "name": "CARKD dehydrates S-NAD(P)HX to NADPH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_6807477" ], "products": [ "species_113548", "species_113581", "species_113529", "species_113600" ], "modifiers": [ [ "species_10486269", "catalyst" ] ], "additional_components": [ "FBgn0036848" ] }, "reaction_10492311": { "compartment": "compartment_70101", "id": "reaction_10492311", "reactome": "R-DME-8938073", "name": "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8938276", "species_29360" ], "products": [ "species_197277", "species_8938282" ], "modifiers": [ [ "species_10492304", "catalyst" ] ], "additional_components": [ "FBgn0034129" ] }, "reaction_10486264": { "compartment": "compartment_5460", "id": "reaction_10486264", "reactome": "R-DME-6806966", "name": "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6807473" ], "products": [ "species_6807477" ], "modifiers": [ [ "species_10486261", "catalyst" ] ], "additional_components": [ "Q9W2Y3", "FBgn0030178" ] }, "reaction_10490427": { "compartment": "compartment_876", "id": "reaction_10490427", "reactome": "R-DME-8869603", "name": "SLC22A13 transports NCA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8869604" ], "products": [ "species_197230" ], "modifiers": [ [ "species_10490424", "catalyst" ] ], "additional_components": [ "FBgn0086365" ] }, "reaction_10440705": { "compartment": "compartment_70101", "id": "reaction_10440705", "reactome": "R-DME-197186", "name": "NAPRT1 dimer transfers PRIB to NCA to form NAMN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_197230", "species_70106" ], "products": [ "species_111294", "species_197220" ], "modifiers": [ [ "species_10440702", "catalyst" ], [ "species_29926", "catalyst" ] ], "additional_components": [ "Q9VQX4", "FBgn0031589" ] }, "reaction_10441349": { "compartment": "compartment_7660", "id": "reaction_10441349", "reactome": "R-DME-200512", "name": "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200492", "species_29358" ], "products": [ "species_8878981", "species_200499" ], "modifiers": [ [ "species_10441346", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VC03", "FBgn0039254" ] }, "reaction_10440974": { "compartment": "compartment_876", "id": "reaction_10440974", "reactome": "R-DME-198818", "name": "SLC2A1,3 transports DeHA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198852" ], "products": [ "species_198827" ], "modifiers": [ [ "species_10440971", "catalyst" ] ], "additional_components": [ "Q7KK97", "FBgn0028563", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562" ] }, "reaction_10441014": { "compartment": "compartment_70101", "id": "reaction_10441014", "reactome": "R-DME-198845", "name": "CYB5A:heme reduces Asc.- to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1497805", "species_10441000" ], "products": [ "species_10440998", "species_198816" ], "modifiers": [ [ "species_10441000", "catalyst" ] ], "additional_components": [ "species_71185", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "CHEBI:36144", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "species_71185", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575" ] }, "reaction_10441011": { "compartment": "compartment_70101", "id": "reaction_10441011", "reactome": "R-DME-198824", "name": "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_10440998", "species_73473" ], "products": [ "species_10441000", "species_29360" ], "modifiers": [ [ "species_10441008", "catalyst" ] ], "additional_components": [ "CHEBI:36144", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "species_71185", "Q9VJC0", "FBgn0032652", "Q9V4N3", "FBgn0264294", "Q8IRR0", "FBgn0029854", "Q9VUZ3", "FBgn0036575", "X2JGK6", "FBgn0036211", "species_113596" ] }, "reaction_10440945": { "compartment": "compartment_70101", "id": "reaction_10440945", "reactome": "R-DME-198813", "name": "GSTO dimers reduce DeHA to AscH-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_198827" ], "products": [ "species_198816", "species_111745" ], "modifiers": [ [ "species_10440942", "catalyst" ] ], "additional_components": [ "Q9VSL6", "FBgn0035907", "Q9VSL5", "FBgn0035906", "Q9VSL3", "FBgn0086348", "Q9VSL2", "FBgn0035904" ] }, "reaction_10441024": { "compartment": "compartment_876", "id": "reaction_10441024", "reactome": "R-DME-198870", "name": "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198836", "species_74113" ], "products": [ "species_83910", "species_198816" ], "modifiers": [ [ "species_10441019", "catalyst" ] ], "additional_components": [ "FBgn0037807" ] }, "reaction_10441433": { "compartment": "compartment_70101", "id": "reaction_10441433", "reactome": "R-DME-200676", "name": "MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200739" ], "products": [ "species_29366", "species_174404" ], "modifiers": [ [ "species_10441430", "catalyst" ] ], "additional_components": [ "Q9VTI0", "FBgn0036157" ] }, "reaction_10441362": { "compartment": "compartment_70101", "id": "reaction_10441362", "reactome": "R-DME-200644", "name": "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_200739" ], "products": [ "species_70106", "species_29364", "species_200640" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10486575": { "compartment": "compartment_5460", "id": "reaction_10486575", "reactome": "R-DME-6808487", "name": "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_6808499", "species_113521" ], "products": [ "species_113529", "species_200679", "species_113600", "species_29376" ], "modifiers": [ [ "species_10486572", "catalyst" ] ], "additional_components": [ "Q9VIC9", "FBgn0032945" ] }, "reaction_10441423": { "compartment": "compartment_70101", "id": "reaction_10441423", "reactome": "R-DME-200661", "name": "MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111353" ], "products": [ "species_29356", "species_200640" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441420": { "compartment": "compartment_876", "id": "reaction_10441420", "reactome": "R-DME-200652", "name": "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200709" ], "products": [ "species_200665" ], "modifiers": [ [ "species_10441417", "catalyst" ] ], "additional_components": [ "Q9VK64", "FBgn0032449", "Q9VGV6", "FBgn0037845", "Q9VGV5", "FBgn0037846" ] }, "reaction_10479244": { "compartment": "compartment_5460", "id": "reaction_10479244", "reactome": "R-DME-5696839", "name": "MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801451", "species_200671", "species_113593" ], "products": [ "species_113548", "species_113581", "species_5389850" ], "modifiers": [ [ "species_10479241", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10486583": { "compartment": "compartment_70101", "id": "reaction_10486583", "reactome": "R-DME-6808496", "name": "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111353", "species_29366" ], "products": [ "species_70106", "species_113528", "species_29364", "species_197969" ], "modifiers": [ [ "species_10486580", "catalyst" ] ], "additional_components": [ "Q9VIC9", "FBgn0032945" ] }, "reaction_10485817": { "compartment": "compartment_5460", "id": "reaction_10485817", "reactome": "R-DME-6801328", "name": "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_5693984" ], "products": [ "species_6801458", "species_29362" ], "modifiers": [ [ "species_10485812", "catalyst" ] ], "additional_components": [ "FBgn0010222" ] }, "reaction_10441409": { "compartment": "compartment_70101", "id": "reaction_10441409", "reactome": "R-DME-200651", "name": "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29424", "species_200739" ], "products": [ "species_200736", "species_197969" ], "modifiers": [ [ "species_10428758", "catalyst" ] ], "additional_components": [ "Q9W457", "FBgn0029823" ] }, "reaction_10441407": { "compartment": "compartment_876", "id": "reaction_10441407", "reactome": "R-DME-200646", "name": "Cytosolic folate export across the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965" ], "products": [ "species_200716" ], "modifiers": [ [ "species_10441404", "catalyst" ] ], "additional_components": [ "B7YZU3", "FBgn0033387", "Q8INF8", "FBgn0051321", "Q9VY22", "FBgn0030576", "A1Z7R6", "FBgn0033388", "Q1EC10", "FBgn0050345", "Q9VA14", "FBgn0039817", "Q0E8E1", "FBgn0260388", "Q961H2", "FBgn0050344" ] }, "reaction_10485825": { "compartment": "compartment_70101", "id": "reaction_10485825", "reactome": "R-DME-6801342", "name": "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803257", "species_113592" ], "products": [ "species_29372", "species_70106", "species_29370", "species_200640" ], "modifiers": [ [ "species_10485822", "catalyst" ] ], "additional_components": [ "FBgn0085453" ] }, "reaction_10485827": { "compartment": "compartment_5460", "id": "reaction_10485827", "reactome": "R-DME-6801456", "name": "MTHFD1L transforms 10-formyl-THF to HCOOH and THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_5389850" ], "products": [ "species_200671", "species_6801451", "species_113593" ], "modifiers": [ [ "species_10479241", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10485830": { "compartment": "compartment_5460", "id": "reaction_10485830", "reactome": "R-DME-6801462", "name": "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6801458", "species_113521" ], "products": [ "species_5389850" ], "modifiers": [ [ "species_10485812", "catalyst" ] ], "additional_components": [ "FBgn0010222" ] }, "reaction_10441461": { "compartment": "compartment_70101", "id": "reaction_10441461", "reactome": "R-DME-200740", "name": "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_200640" ], "products": [ "species_111353" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441459": { "compartment": "compartment_70101", "id": "reaction_10441459", "reactome": "R-DME-200735", "name": "SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200736", "species_197969" ], "products": [ "species_29424", "species_200739" ], "modifiers": [ [ "species_10428758", "catalyst" ] ], "additional_components": [ "Q9W457", "FBgn0029823" ] }, "reaction_10441457": { "compartment": "compartment_876", "id": "reaction_10441457", "reactome": "R-DME-200729", "name": "SLC46A1 transports FOLA from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200716" ], "products": [ "species_197965" ], "modifiers": [ [ "species_10441404", "catalyst" ] ], "additional_components": [ "B7YZU3", "FBgn0033387", "Q8INF8", "FBgn0051321", "Q9VY22", "FBgn0030576", "A1Z7R6", "FBgn0033388", "Q1EC10", "FBgn0050345", "Q9VA14", "FBgn0039817", "Q0E8E1", "FBgn0260388", "Q961H2", "FBgn0050344" ] }, "reaction_10440753": { "compartment": "compartment_70101", "id": "reaction_10440753", "reactome": "R-DME-197972", "name": "DHF is reduced to tetrahydrofolate (THF)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_73604", "species_29364" ], "products": [ "species_111355", "species_29366" ], "modifiers": [ [ "species_10440748", "catalyst" ] ], "additional_components": [ "FBgn0004087" ] }, "reaction_10440751": { "compartment": "compartment_70101", "id": "reaction_10440751", "reactome": "R-DME-197963", "name": "DHFR2 reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10440748", "catalyst" ] ], "additional_components": [ "FBgn0004087" ] }, "reaction_10441455": { "compartment": "compartment_70616", "id": "reaction_10441455", "reactome": "R-DME-200720", "name": "SLC25A32 transports THF from mitochondrial matrix to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671" ], "products": [ "species_111355" ], "modifiers": [ [ "species_10441438", "catalyst" ] ], "additional_components": [ "FBgn0033391" ] }, "reaction_10441453": { "compartment": "compartment_70101", "id": "reaction_10441453", "reactome": "R-DME-200718", "name": "MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200640" ], "products": [ "species_29366", "species_200739" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441451": { "compartment": "compartment_70101", "id": "reaction_10441451", "reactome": "R-DME-200711", "name": "MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29460", "species_197969" ], "products": [ "species_29372", "species_29370", "species_111353" ], "modifiers": [ [ "species_10441359", "catalyst" ] ], "additional_components": [ "O96553", "FBgn0020385" ] }, "reaction_10441448": { "compartment": "compartment_5460", "id": "reaction_10441448", "reactome": "R-DME-200682", "name": "Mitochondrial FPGS-1 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_113593", "species_113552" ], "products": [ "species_113548", "species_113581", "species_200679" ], "modifiers": [ [ "species_10441445", "catalyst" ] ], "additional_components": [ "FBgn0030407" ] }, "reaction_10440743": { "compartment": "compartment_70101", "id": "reaction_10440743", "reactome": "R-DME-197958", "name": "FPGS-2 transforms THF to THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111355", "species_113592" ], "products": [ "species_29372", "species_29370", "species_197969" ], "modifiers": [ [ "species_10440740", "catalyst" ] ], "additional_components": [ "FBgn0030407" ] }, "reaction_10441443": { "compartment": "compartment_70101", "id": "reaction_10441443", "reactome": "R-DME-200681", "name": "FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_200665", "species_113592" ], "products": [ "species_29372", "species_29370", "species_174404" ], "modifiers": [ [ "species_10440740", "catalyst" ] ], "additional_components": [ "FBgn0030407" ] }, "reaction_10498781": { "compartment": "compartment_70101", "id": "reaction_10498781", "reactome": "R-DME-9709098", "name": "DHFR dimer reduces FOLA to DHF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_197965", "species_70106", "species_29364" ], "products": [ "species_29366", "species_73604" ], "modifiers": [ [ "species_10498778", "catalyst" ] ], "additional_components": [ "P17719", "FBgn0004087" ] }, "reaction_10469673": { "compartment": "compartment_5460", "id": "reaction_10469673", "reactome": "R-DME-4167509", "name": "Mitochondrial BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3065953" ], "products": [ "species_29582", "species_29444" ], "modifiers": [ [ "species_10469670", "catalyst" ] ], "additional_components": [ "FBgn0040069" ] }, "reaction_10468376": { "compartment": "compartment_70101", "id": "reaction_10468376", "reactome": "R-DME-3323111", "name": "Cytoslic carboxylases translocate to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468374" ], "products": [ "species_10467405" ], "modifiers": [], "additional_components": [ "Q0E9E2", "FBgn0027580", "species_266099", "Q9V9T5", "FBgn0039877", "Q9V9A7", "FBgn0042083", "Q0E9E2", "FBgn0027580", "species_266099", "Q9V9T5", "FBgn0039877", "Q9V9A7", "FBgn0042083" ] }, "reaction_10467413": { "compartment": "compartment_984", "id": "reaction_10467413", "reactome": "R-DME-3076905", "name": "Extracellular BTD hydrolyses BCTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_3076887" ], "products": [ "species_199238", "species_351991" ], "modifiers": [ [ "species_10467410", "catalyst" ] ], "additional_components": [ "FBgn0040069" ] }, "reaction_10441069": { "compartment": "compartment_70101", "id": "reaction_10441069", "reactome": "R-DME-199202", "name": "Phosphopantetheine conjugation of the ACP domain of FAS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441061", "species_76194" ], "products": [ "species_10432485", "species_158466" ], "modifiers": [ [ "species_10441066", "catalyst" ] ], "additional_components": [ "FBgn0283427", "FBgn0283427", "FBgn0052099" ] }, "reaction_10440669": { "compartment": "compartment_70101", "id": "reaction_10440669", "reactome": "R-DME-196840", "name": "3xPPCDC:3FMN decarboxylates PPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196834" ], "products": [ "species_196767", "species_113528" ], "modifiers": [ [ "species_10440666", "catalyst" ] ], "additional_components": [ "species_76629", "Q8MKK3", "FBgn0050290" ] }, "reaction_10440646": { "compartment": "compartment_70101", "id": "reaction_10440646", "reactome": "R-DME-196754", "name": "COASY transfers an adenylyl group from ATP to PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196767", "species_113592" ], "products": [ "species_111294", "species_196778" ], "modifiers": [ [ "species_10440643", "catalyst" ] ], "additional_components": [ "FBgn0035632" ] }, "reaction_10440677": { "compartment": "compartment_70101", "id": "reaction_10440677", "reactome": "R-DME-196857", "name": "PANK2 phosphorylates PanK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196820" ], "products": [ "species_29370", "species_196786" ], "modifiers": [ [ "species_10440674", "catalyst" ] ], "additional_components": [ "FBgn0011205" ] }, "reaction_10441076": { "compartment": "compartment_70101", "id": "reaction_10441076", "reactome": "R-DME-199203", "name": "PANK1/3/4 phosphorylate PanK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196820" ], "products": [ "species_29370", "species_196786" ], "modifiers": [ [ "species_10441071", "catalyst" ] ], "additional_components": [ "FBgn0011205" ] }, "reaction_10440659": { "compartment": "compartment_70101", "id": "reaction_10440659", "reactome": "R-DME-196773", "name": "COASY phosphorylates DP-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_196778" ], "products": [ "species_29370", "species_76194" ], "modifiers": [ [ "species_10440643", "catalyst" ] ], "additional_components": [ "FBgn0035632" ] }, "reaction_10455438": { "compartment": "compartment_70101", "id": "reaction_10455438", "reactome": "R-DME-947531", "name": "Molybdenum ion transfer onto molybdopterin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_947561", "species_947496" ], "products": [ "species_111294", "species_947539", "species_76577" ], "modifiers": [ [ "species_10455435", "catalyst" ] ], "additional_components": [ "species_29926", "P39205", "FBgn0000316" ] }, "reaction_10455403": { "compartment": "compartment_70101", "id": "reaction_10455403", "reactome": "R-DME-947499", "name": "Exchange of oxygen with sulfur in MoCo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_947539", "species_111707" ], "products": [ "species_947575", "species_29432" ], "modifiers": [ [ "species_10455400", "catalyst" ] ], "additional_components": [ "FBgn0002641" ] }, "reaction_10455450": { "compartment": "compartment_70101", "id": "reaction_10455450", "reactome": "R-DME-947535", "name": "Cyclisation of GTP to precursor Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356", "species_71284" ], "products": [ "species_111294", "species_947537", "species_947703", "species_174390" ], "modifiers": [ [ "species_10455447", "catalyst" ] ], "additional_components": [ "CHEBI:33722", "Q8IQF1", "FBgn0263241" ] }, "reaction_10455426": { "compartment": "compartment_70101", "id": "reaction_10455426", "reactome": "R-DME-947514", "name": "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455410", "species_111707" ], "products": [ "species_10455415", "species_29432" ], "modifiers": [ [ "species_10455423", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VLJ8", "FBgn0032054", "species_1562550", "Q9VLJ8", "FBgn0032054", "Q9VKD3", "FBgn0032393" ] }, "reaction_10497008": { "compartment": "compartment_12045", "id": "reaction_10497008", "reactome": "R-DME-9026967", "name": "VKORC1 inhibitors binds VKORC1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435910", "species_9035082" ], "products": [ "species_10435913" ], "modifiers": [], "additional_components": [ "A1ZAJ5", "FBgn0053544", "A1ZAJ5", "FBgn0053544" ] }, "reaction_10486243": { "compartment": "compartment_17957", "id": "reaction_10486243", "reactome": "R-DME-6806674", "name": "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806891", "species_6806657" ], "products": [ "species_6806362", "species_6806656" ], "modifiers": [ [ "species_10486240", "catalyst" ] ], "additional_components": [ "FBgn0028375" ] }, "reaction_10435915": { "compartment": "compartment_12045", "id": "reaction_10435915", "reactome": "R-DME-159790", "name": "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_6806366" ], "products": [ "species_6806362" ], "modifiers": [ [ "species_10435910", "catalyst" ], [ "species_10435913", "inhibitor" ] ], "additional_components": [ "A1ZAJ5", "FBgn0053544", "A1ZAJ5", "FBgn0053544" ] }, "reaction_10486235": { "compartment": "compartment_17957", "id": "reaction_10486235", "reactome": "R-DME-6806647", "name": "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_156540", "species_6806366" ], "products": [ "species_6806362" ], "modifiers": [ [ "species_10486232", "catalyst" ] ], "additional_components": [ "FBgn0053544" ] }, "reaction_10455791": { "compartment": "compartment_70101", "id": "reaction_10455791", "reactome": "R-DME-975635", "name": "BCMO1:Fe2+ cleaves betaC to atRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_975643" ], "products": [ "species_975622" ], "modifiers": [ [ "species_10455788", "catalyst" ] ], "additional_components": [ "Q9VFS2", "FBgn0002937", "species_111793" ] }, "reaction_10465678": { "compartment": "compartment_70101", "id": "reaction_10465678", "reactome": "R-DME-2404142", "name": "atROL binds RBP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431845", "species_2473616" ], "products": [ "species_10465676" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_2473604", "Q8INK3", "FBgn0037913" ] }, "reaction_10455773": { "compartment": "compartment_984", "id": "reaction_10455773", "reactome": "R-DME-975594", "name": "PLB1 hydrolyses RPALM to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_975591" ], "products": [ "species_975590", "species_426576" ], "modifiers": [ [ "species_10455770", "catalyst" ] ], "additional_components": [ "FBgn0036939" ] }, "reaction_10465674": { "compartment": "compartment_70101", "id": "reaction_10465674", "reactome": "R-DME-2399913", "name": "atRAL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975622", "species_10455775" ], "products": [ "species_10455779" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_975622" ] }, "reaction_10467095": { "compartment": "compartment_70101", "id": "reaction_10467095", "reactome": "R-DME-2855259", "name": "atROL binds RBP1 (parenchymal cell)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2473610", "species_10431845" ], "products": [ "species_10465680" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_2473604" ] }, "reaction_10455781": { "compartment": "compartment_70101", "id": "reaction_10455781", "reactome": "R-DME-975633", "name": "atROL binds to RBP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_975590", "species_10455775" ], "products": [ "species_10455777" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_2473604" ] }, "reaction_10467093": { "compartment": "compartment_70101", "id": "reaction_10467093", "reactome": "R-DME-2855252", "name": "AKRs reduce RBP2:atRAL to RBP2:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455779", "species_70106", "species_29364" ], "products": [ "species_10455777", "species_29366" ], "modifiers": [ [ "species_10467090", "catalyst" ] ], "additional_components": [ "Q8INK3", "FBgn0037913", "species_975622", "Q8INK3", "FBgn0037913", "species_2473604", "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10470451": { "compartment": "compartment_5460", "id": "reaction_10470451", "reactome": "R-DME-5164399", "name": "BCO2:Fe2+ cleaves betaC to APO10al and bION", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_5164389" ], "products": [ "species_5164390", "species_5164383" ], "modifiers": [ [ "species_10470448", "catalyst" ] ], "additional_components": [ "Q9VFS2", "FBgn0002937", "species_111793" ] }, "reaction_10465682": { "compartment": "compartment_70101", "id": "reaction_10465682", "reactome": "R-DME-2404144", "name": "Parenchymal atROL translocates to HSCs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465680" ], "products": [ "species_10431845", "species_2473616" ], "modifiers": [], "additional_components": [ "Q8INK3", "FBgn0037913", "species_2473604", "FBgn0037913" ] }, "reaction_10491072": { "compartment": "compartment_70101", "id": "reaction_10491072", "reactome": "R-DME-8874705", "name": "TTPA transports alpha-TOH from lysosomal membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491068" ], "products": [ "species_10491070" ], "modifiers": [], "additional_components": [ "species_8874708", "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783", "species_8874708", "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783" ] }, "reaction_10491074": { "compartment": "compartment_70101", "id": "reaction_10491074", "reactome": "R-DME-8874718", "name": "TTPA binds alpha-TOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491066", "species_8874708" ], "products": [ "species_10491068" ], "modifiers": [], "additional_components": [ "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783", "species_8874708", "Q8T9G7", "FBgn0032785", "Q2MGL9", "FBgn0053965", "Q9VJN4", "FBgn0051826", "Q95R34", "FBgn0023525", "Q6NLM7", "FBgn0053514", "Q9VM11", "FBgn0031914", "Q9V9V4", "FBgn0039864", "Q7K1M4", "FBgn0033434", "Q9VM12", "FBgn0031913", "Q9VCJ2", "FBgn0039107", "Q8I099", "FBgn0037323", "Q9W408", "FBgn0029863", "Q9VCJ3", "FBgn0039106", "Q8IPJ5", "FBgn0051636", "Q9W503", "FBgn0029608", "A1Z7X8", "FBgn0033437", "Q9VD09", "FBgn0038966", "Q8SXR4", "FBgn0050339", "Q2MGL8", "FBgn0053966", "Q9VIW5", "FBgn0032783" ] }, "reaction_10459358": { "compartment": "compartment_70101", "id": "reaction_10459358", "reactome": "R-DME-1474184", "name": "DHNTP is dephosphorylated by PTPS to PTHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474124" ], "products": [ "species_1475054", "species_1474179" ], "modifiers": [ [ "species_10459355", "catalyst" ] ], "additional_components": [ "species_1562550", "P48611", "FBgn0003141" ] }, "reaction_10459534": { "compartment": "compartment_70101", "id": "reaction_10459534", "reactome": "R-DME-1475414", "name": "PTHP is reduced to BH4 by sepiapterin reductase (SPR)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1474179", "species_29364" ], "products": [ "species_29870", "species_29366" ], "modifiers": [ [ "species_10459531", "catalyst" ] ], "additional_components": [ "O76752", "FBgn0014032" ] }, "reaction_10459879": { "compartment": "compartment_70101", "id": "reaction_10459879", "reactome": "R-DME-1497796", "name": "BH2 binding can lead to eNOS uncoupling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441857", "species_1497857" ], "products": [ "species_29870", "species_10459877" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "species_1497857", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10459347": { "compartment": "compartment_70101", "id": "reaction_10459347", "reactome": "R-DME-1474146", "name": "GCH1 reduces GTP to dihydroneopterin triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29356" ], "products": [ "species_1474124", "species_29460" ], "modifiers": [ [ "species_10459344", "catalyst" ], [ "species_29502", "catalyst" ], [ "species_29870", "inhibitor" ] ], "additional_components": [ "P48596", "FBgn0003162" ] }, "reaction_10459555": { "compartment": "compartment_70101", "id": "reaction_10459555", "reactome": "R-DME-1475422", "name": "PTPS is phosphorylated by cGMP-dependant protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459538", "species_113592" ], "products": [ "species_29370", "species_10459355" ], "modifiers": [ [ "species_10459552", "catalyst" ] ], "additional_components": [ "P48611", "FBgn0003141", "species_1562550", "P48611", "FBgn0003141", "Q9VL34", "FBgn0032187", "Q03043", "FBgn0000721", "Q03042", "FBgn0000442" ] }, "reaction_10459890": { "compartment": "compartment_70101", "id": "reaction_10459890", "reactome": "R-DME-1497869", "name": "Salvage - Sepiapterin is reduced to BH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_1497811", "species_29364" ], "products": [ "species_1497857", "species_29366" ], "modifiers": [ [ "species_10459531", "catalyst" ] ], "additional_components": [ "O76752", "FBgn0014032" ] }, "reaction_10459888": { "compartment": "compartment_70101", "id": "reaction_10459888", "reactome": "R-DME-1497853", "name": "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10459886" ], "products": [ "species_29370", "species_10459531" ], "modifiers": [ [ "species_10459552", "catalyst" ] ], "additional_components": [ "O76752", "FBgn0014032", "O76752", "FBgn0014032", "Q9VL34", "FBgn0032187", "Q03043", "FBgn0000721", "Q03042", "FBgn0000442" ] }, "reaction_10446462": { "compartment": "compartment_17951", "id": "reaction_10446462", "reactome": "R-DME-389550", "name": "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389548", "species_389556" ], "products": [ "species_193465", "species_389536", "species_389537", "species_113602" ], "modifiers": [ [ "species_10446459", "catalyst" ] ], "additional_components": [ "B7Z0E0", "FBgn0001248" ] }, "reaction_10465151": { "compartment": "compartment_5460", "id": "reaction_10465151", "reactome": "R-DME-2162193", "name": "DHDB is methylated to MHDB by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162209" ], "products": [ "species_2162252", "species_113529", "species_2162215" ], "modifiers": [ [ "species_10465137", "catalyst" ] ], "additional_components": [ "FBgn0032922" ] }, "reaction_10465148": { "compartment": "compartment_70616", "id": "reaction_10465148", "reactome": "R-DME-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162214", "species_2162213" ], "products": [ "species_2162207", "species_159450" ], "modifiers": [ [ "species_10465145", "catalyst" ] ], "additional_components": [ "FBgn0037574" ] }, "reaction_10465174": { "compartment": "compartment_5460", "id": "reaction_10465174", "reactome": "R-DME-2162253", "name": "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162257", "species_2162256" ], "products": [ "species_159450", "species_2162214" ], "modifiers": [ [ "species_10465171", "catalyst" ] ], "additional_components": [ "Q9V9Z3", "FBgn0051005", "species_29926", "Q9VP87", "FBgn0037044" ] }, "reaction_10465140": { "compartment": "compartment_5460", "id": "reaction_10465140", "reactome": "R-DME-2162186", "name": "DeMQ10H2 is methylated to Q10H2 by COQ3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162265", "species_2162212" ], "products": [ "species_2162252", "species_113529", "species_2162198" ], "modifiers": [ [ "species_10465137", "catalyst" ] ], "additional_components": [ "FBgn0032922" ] }, "reaction_216133": { "compartment": "compartment_70101", "id": "reaction_216133", "reactome": "R-DME-216133", "name": "Dissociation of CI from COS", "reversible": "false", "notes": "Coastal2 (COS) phosphorylated on Ser572 has reduced affinity for Cubitus Interruptus (CI). This may contribute to partial dissociation of CI from COS complexes.", "reactants": [ "species_206734" ], "products": [ "species_206046", "species_206634" ], "modifiers": [], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P91682", "phospho-smo" ] }, "reaction_209220": { "compartment": "compartment_70101", "id": "reaction_209220", "reactome": "R-DME-209220", "name": "Liberation of CI from SU(FU) repression", "reversible": "false", "notes": "Cubitus Interruptus (CI) that is spared from proteolysis is liberated from the repressive effects of its direct binding partner, Supressor of Fused (SU(FU)), by Fused (FU) Ser/Thr kinase activity. FU is believed to phosphorylate SU(FU) but it is not known if this relieves repression.", "reactants": [ "species_113592", "species_206634", "species_206802" ], "products": [ "species_205950", "species_206046", "species_29370", "species_206634" ], "modifiers": [ [ "species_205872", "catalyst" ] ], "additional_components": [ "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P91682", "phospho-smo", "Q27279", "Phospho SU(FU)", "P19538", "ci", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P91682", "phospho-smo" ] }, "reaction_209163": { "compartment": "compartment_13231", "id": "reaction_209163", "reactome": "R-DME-209163", "name": "CI transports from the cytosol to the nucleus", "reversible": "false", "notes": "Cubitus Interruptus (CI) access to the nucleus increases in response to Hedgehog signalling, most likely due to reduced cytoplasmic tethering by both Coastal2 (COS) and Suppressor of Fused (SU(FU)) complexes. However, the vast majority of CI is cytoplasmic.", "reactants": [ "species_206046" ], "products": [ "species_205911" ], "modifiers": [], "additional_components": [] }, "reaction_209215": { "compartment": "compartment_7660", "id": "reaction_209215", "reactome": "R-DME-209215", "name": "CI activates transcription", "reversible": "false", "notes": "Cubitus Interruptus (CI) activates transcription of ptc and several tissue-specific target genes that include direct CI binding sites in their regulatory sequences. CREB binding protein, CBP (NEJ) co-activator contributes to transcriptional activation.", "reactants": [ "species_205911" ], "products": [ "species_205911" ], "modifiers": [], "additional_components": [] }, "reaction_209178": { "compartment": "compartment_876", "id": "reaction_209178", "reactome": "R-DME-209178", "name": "N-HH binds to PTC receptor complex", "reversible": "false", "notes": "N-HH bound to Dally-like protein (DLP) is presented to Patched (PTC) receptor and Induced Hedgehog/Brother of Induced Hedgehog (IHOG/BOI) co-receptor to form a ternary complex at the plasma membrane. N-HH binds directly to PTC. Binding is enhanced by the putative co-receptor, IHOG/BOI, which is a type I transmembrane protein that can bind N-HH directly in the presence of Heparin. Signal transduction is also enhanced by DLP, implying that heparan sulphate proteoglycan (HSPG)-associated N-HH may be the most potent form of Hedgehog. Binding of N-HH to PTC leads to PTC internalisation and lysosomal degradation, resulting in a reduction of extracellular N-HH levels and a relief of repression of Smoothened (SMO) by PTC, which depends on the opposing actions of free PTC and N-HH bound PTC.", "reactants": [ "species_216284", "species_206021", "species_216135" ], "products": [ "species_216226" ], "modifiers": [], "additional_components": [ "Q02936", "hh", "Q9GPL5", "DLP", "Q9VM64", "ihog", "Q9W4Y6", "BOI", "Q02936", "hh", "Q9VM64", "ihog", "Q9W4Y6", "BOI", "P18502", "ptc", "Q9GPL5", "DLP" ] }, "reaction_216222": { "compartment": "compartment_70101", "id": "reaction_216222", "reactome": "R-DME-216222", "name": "COS binds to SMO", "reversible": "false", "notes": "SMO:COS:FU:CI complexes are present prior to Hedgehog signalling owing to direct binding of Smoothened (SMO) to both Coastal2 (COS) and the Ser/Thr kinase Fused (FU).", "reactants": [ "species_216188", "species_206086" ], "products": [ "species_216146" ], "modifiers": [], "additional_components": [ "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_209253": { "compartment": "compartment_70101", "id": "reaction_209253", "reactome": "R-DME-209253", "name": "Autophosphorylated FU phosphorylates COS", "reversible": "false", "notes": "The Ser/Thr protein kinase, Fused (FU), is capable of autophosphorylation and is proposed to be activated by phosphorylation on at least Thr158 and probably on other residues too. Costal2 (COS), bound to the phosphorylated transmembrane receptor Smoothened (SMO), is itself phosphorylated by FU at Ser572 and Ser931. Both FU and COS promote phosphorylation of SMO and its accumulation at the plasma membrane resulting in a positive feedback loop.", "reactants": [ "species_216158", "species_113592" ], "products": [ "species_206734", "species_29370" ], "modifiers": [ [ "species_205872", "catalyst" ] ], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_216202": { "compartment": "compartment_876", "id": "reaction_216202", "reactome": "R-DME-216202", "name": "Phosphorylated SMO changes conformation and is activated", "reversible": "false", "notes": "The Smoothened (SMO) large terminal cytoplasmic domain changes conformation in response to phosphorylation and becomes active. The localisation of SMO and its partners shifts from internal vesicles towards the plasma membrane. SMO stability increases results in the SMO:COS:FU:CI complexes at the plasma membrane becoming more abundant.Activation of SMO leads to reduced association of the Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase 1 alpha (CKIalpha), and Casein kinase I epsilon (DCO) with Costal2 (COS). This leads to a reduced phosphorylation of Cubitus Interruptus (CI) and inhibition of CI proteolysis and processing. This increases full-length CI protein levels.", "reactants": [ "species_206727" ], "products": [ "species_216158" ], "modifiers": [], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_209168": { "compartment": "compartment_70101", "id": "reaction_209168", "reactome": "R-DME-209168", "name": "Phosphorylation of SMO by CKIalpha", "reversible": "false", "notes": "Priming phosphorylation of the transmembrane protein Smoothened (SMO) leads to additional phosphorylation by Casein kinase I alpha (CKIalpha) at Ser670, Ser673, Ser690, Ser693, Ser743, and Ser746. Even though SMO has been shown to be explicitly phosphorylated by CKIalpha, phosphorylation of these residues by other CK1 isoforms cannot be ruled out. In addition, other residues are probably phosphorylated by unidentified kinases.", "reactants": [ "species_216105", "species_113592" ], "products": [ "species_29370", "species_206727" ], "modifiers": [ [ "species_206666", "catalyst" ] ], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209341": { "compartment": "compartment_70101", "id": "reaction_209341", "reactome": "R-DME-209341", "name": "Phosphorylation of SMO by PKA-C1", "reversible": "false", "notes": "The Ser/Thr kinase, Protein kinase A (PKA-C1) carries out priming phosphorylation of the transmembrane protein Smoothened (SMO) at Ser667, Ser687, and Ser740.", "reactants": [ "species_113592", "species_216146" ], "products": [ "species_29370", "species_216105" ], "modifiers": [ [ "species_206865", "catalyst" ] ], "additional_components": [ "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "P91682", "phospho-smo", "P23647", "Phospho FU", "O16844", "Phospho (2 sites) COS", "P19538", "ci", "Q24170", "Phospho KSR", "P11346", "Raf", "Q24324", "phospho-Dsor1", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q95U75", "PAR-1", "Q7KNQ9", "cnk", "Q8ML92", "AVE", "P23696", "mts", "P36179", "Pp2A-29B" ] }, "reaction_10458816": { "compartment": "compartment_876", "id": "reaction_10458816", "reactome": "R-DME-1296127", "name": "Activation of voltage gated Potassium channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458813", "catalyst" ] ], "additional_components": [ "M9PHI0", "FBgn0263220", "P17972", "FBgn0003386", "A8DYR5", "FBgn0085395", "Q7JPB9", "FBgn0003353", "P17970", "FBgn0262593", "Q02280", "FBgn0000535", "A1ZB14", "FBgn0011589", "P17971", "FBgn0005564", "A1Z856", "FBgn0033494", "P08510", "FBgn0003380" ] }, "reaction_10451102": { "compartment": "compartment_7660", "id": "reaction_10451102", "reactome": "R-DME-450550", "name": "PKCalpha phosphorylates HuR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10429721" ], "products": [ "species_113582", "species_10450960" ], "modifiers": [ [ "species_10451099", "catalyst" ] ], "additional_components": [ "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "FBgn0003091" ] }, "reaction_10451085": { "compartment": "compartment_7660", "id": "reaction_10451085", "reactome": "R-DME-450494", "name": "HuR binds mRNAs in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429721", "species_450613" ], "products": [ "species_10450946" ], "modifiers": [], "additional_components": [ "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400" ] }, "reaction_10451097": { "compartment": "compartment_7660", "id": "reaction_10451097", "reactome": "R-DME-450533", "name": "PKCdelta phosphorylates HuR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10429721" ], "products": [ "species_113582", "species_10450973" ], "modifiers": [ [ "species_10451094", "catalyst" ] ], "additional_components": [ "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "FBgn0259680" ] }, "reaction_10450981": { "compartment": "compartment_7660", "id": "reaction_10450981", "reactome": "R-DME-450387", "name": "HuR binds the CRM1 nuclear export machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450944", "species_10450977", "species_10450932", "species_10450937", "species_10450939", "species_10437629" ], "products": [ "species_10450979" ], "modifiers": [], "additional_components": [ "FBgn0014879", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "FBgn0033483", "FBgn0034282", "FBgn0010660", "FBgn0020497", "Q9TVM2", "FBgn0020497", "Q9W1X4", "FBgn0010660", "Q9V895", "FBgn0034282", "Q8MUJ1", "FBgn0033483", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "P53997", "FBgn0014879" ] }, "reaction_10453156": { "compartment": "compartment_7660", "id": "reaction_10453156", "reactome": "R-DME-517705", "name": "p-S318,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450973", "species_517622" ], "products": [ "species_10450975" ], "modifiers": [], "additional_components": [ "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263" ] }, "reaction_10453154": { "compartment": "compartment_7660", "id": "reaction_10453154", "reactome": "R-DME-517674", "name": "p-S158,221-HuR binds mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450960", "species_450605" ], "products": [ "species_10450962" ], "modifiers": [], "additional_components": [ "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263" ] }, "reaction_10451200": { "compartment": "compartment_7660", "id": "reaction_10451200", "reactome": "R-DME-450595", "name": "HuR:mRNA complex translocates from the nucleus to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450979" ], "products": [ "species_10451164", "species_10451198" ], "modifiers": [], "additional_components": [ "Q9TVM2", "FBgn0020497", "Q9W1X4", "FBgn0010660", "Q9V895", "FBgn0034282", "Q8MUJ1", "FBgn0033483", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263", "P53997", "FBgn0014879", "FBgn0033483", "Q9VYI0", "FBgn0086675", "P16914", "FBgn0260400", "M9PBZ2", "FBgn0010263" ] }, "reaction_10451005": { "compartment": "compartment_70101", "id": "reaction_10451005", "reactome": "R-DME-450400", "name": "ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451001", "species_10450986", "species_450597" ], "products": [ "species_10451003" ], "modifiers": [], "additional_components": [ "FBgn0011837", "FBgn0024921", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837" ] }, "reaction_10451052": { "compartment": "compartment_70101", "id": "reaction_10451052", "reactome": "R-DME-450463", "name": "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451003" ], "products": [ "species_10450995", "species_29370" ], "modifiers": [ [ "species_10439416", "catalyst" ] ], "additional_components": [ "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "FBgn0013987" ] }, "reaction_10451031": { "compartment": "compartment_70101", "id": "reaction_10451031", "reactome": "R-DME-450431", "name": "ZFP36 (TTP) recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448993", "species_10451027", "species_10449000", "species_10451003", "species_10449102" ], "products": [ "species_10451029" ], "modifiers": [], "additional_components": [ "FBgn0034921", "FBgn0020261", "FBgn0036534", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "Q5U127", "FBgn0036534", "E1JJR3", "FBgn0020261", "Q9W1H5", "FBgn0034921" ] }, "reaction_10450999": { "compartment": "compartment_70101", "id": "reaction_10450999", "reactome": "R-DME-450394", "name": "p-S60,S186-ZFP36 (Tristetraproline, TTP) binds 14-3-3beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450995", "species_10432008" ], "products": [ "species_10450997" ], "modifiers": [], "additional_components": [ "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837", "P29310", "14-3-3zeta", "Q9VRV8", "FBgn0024921", "P47980", "FBgn0011837" ] }, "reaction_10453023": { "compartment": "compartment_70101", "id": "reaction_10453023", "reactome": "R-DME-482788", "name": "p-S54,92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451075", "species_10432008" ], "products": [ "species_10453021" ], "modifiers": [], "additional_components": [ "P47980", "FBgn0011837", "P29310", "14-3-3zeta", "P47980", "FBgn0011837" ] }, "reaction_10451083": { "compartment": "compartment_70101", "id": "reaction_10451083", "reactome": "R-DME-450490", "name": "Protein Kinase B/Akt phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451069" ], "products": [ "species_10451011", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "P47980", "FBgn0011837", "P47980", "FBgn0011837" ] }, "reaction_10451081": { "compartment": "compartment_70101", "id": "reaction_10451081", "reactome": "R-DME-450488", "name": "BRF1 Complex recruits RNA degradation activities", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448993", "species_10451027", "species_10449000", "species_10451069", "species_10449102" ], "products": [ "species_10451079" ], "modifiers": [], "additional_components": [ "FBgn0034921", "FBgn0020261", "FBgn0036534", "P47980", "FBgn0011837", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "Q9VC93", "FBgn0039183", "Q9VKJ4", "FBgn0032346", "Q29QQ9", "FBgn0034065", "Q8T4A9", "FBgn0030789", "Q9VK19", "FBgn0032487", "Q9VGZ2", "FBgn0037815", "Q9VW53", "FBgn0036916", "Q9W1M9", "FBgn0034879", "Q8IPX7", "FBgn0260648", "P47980", "FBgn0011837", "Q5U127", "FBgn0036534", "E1JJR3", "FBgn0020261", "Q9W1H5", "FBgn0034921" ] }, "reaction_10451015": { "compartment": "compartment_70101", "id": "reaction_10451015", "reactome": "R-DME-450406", "name": "p-S92,203-BRF1 binds 14-3-3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451011", "species_10432008" ], "products": [ "species_10451013" ], "modifiers": [], "additional_components": [ "P47980", "FBgn0011837", "P29310", "14-3-3zeta", "P47980", "FBgn0011837" ] }, "reaction_10451077": { "compartment": "compartment_70101", "id": "reaction_10451077", "reactome": "R-DME-450474", "name": "MK2 phosphorylates BRF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451069" ], "products": [ "species_10451075", "species_29370" ], "modifiers": [ [ "species_10439416", "catalyst" ] ], "additional_components": [ "P47980", "FBgn0011837", "P47980", "FBgn0011837", "FBgn0013987" ] }, "reaction_10451092": { "compartment": "compartment_70101", "id": "reaction_10451092", "reactome": "R-DME-450517", "name": "Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450523", "species_10451067" ], "products": [ "species_10451069" ], "modifiers": [], "additional_components": [ "FBgn0011837", "P47980", "FBgn0011837" ] }, "reaction_10451049": { "compartment": "compartment_70101", "id": "reaction_10451049", "reactome": "R-DME-450434", "name": "AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451043", "species_450444" ], "products": [ "species_10451047" ], "modifiers": [], "additional_components": [ "Q08473", "FBgn0263396", "Q08473", "FBgn0263396" ] }, "reaction_10451065": { "compartment": "compartment_70101", "id": "reaction_10451065", "reactome": "R-DME-450466", "name": "AUF1:mRNA complex is destroyed", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451063" ], "products": [], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q08473", "FBgn0263396", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10451160": { "compartment": "compartment_70101", "id": "reaction_10451160", "reactome": "R-DME-450580", "name": "AUF1 (hnRNP D0) is ubiquitinylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451156", "species_10426987" ], "products": [ "species_10451063" ], "modifiers": [], "additional_components": [ "P21187", "FBgn0265297", "P11147", "FBgn0266599", "Q08473", "FBgn0263396", "Q8IQW5", "FBgn0031037", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08473", "FBgn0263396" ] }, "reaction_10451158": { "compartment": "compartment_70101", "id": "reaction_10451158", "reactome": "R-DME-450551", "name": "AUF1 binds translation and heat shock proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430497", "species_10451154", "species_10451107", "species_10451047", "species_10447995", "species_10435551" ], "products": [ "species_10451156" ], "modifiers": [], "additional_components": [ "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "FBgn0031037", "Q08473", "FBgn0263396", "FBgn0266599", "FBgn0265297", "P21187", "FBgn0265297", "P11147", "FBgn0266599", "Q08473", "FBgn0263396", "Q8IQW5", "FBgn0031037", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10451162": { "compartment": "compartment_70101", "id": "reaction_10451162", "reactome": "R-DME-450592", "name": "KSRP binds AU-rich element in 3' UTR of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_450386", "species_10451020" ], "products": [ "species_10451022" ], "modifiers": [], "additional_components": [ "FBgn0014870", "A1ZAK8", "FBgn0014870" ] }, "reaction_10451208": { "compartment": "compartment_70101", "id": "reaction_10451208", "reactome": "R-DME-450620", "name": "p-S193-KSRP binds 14-3-3zeta in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10451088", "species_10451202" ], "products": [ "species_10451206" ], "modifiers": [], "additional_components": [ "FBgn0014870", "A1ZAK8", "FBgn0014870", "P29310", "14-3-3zeta" ] }, "reaction_10451090": { "compartment": "compartment_70101", "id": "reaction_10451090", "reactome": "R-DME-450499", "name": "Protein Kinase B (AKT) phosphorylates KSRP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10451020" ], "products": [ "species_10451088", "species_29370" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0014870", "FBgn0014870" ] }, "reaction_10492435": { "compartment": "compartment_7660", "id": "reaction_10492435", "reactome": "R-DME-8938853", "name": "CDK6 binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492431", "species_10492429" ], "products": [ "species_10492433" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0016131", "Q7K306", "FBgn0016131", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10492437": { "compartment": "compartment_7660", "id": "reaction_10492437", "reactome": "R-DME-8938867", "name": "CCND3,(CCND1,CCND2) binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457981", "species_10489792" ], "products": [ "species_10489796" ], "modifiers": [], "additional_components": [ "FBgn0010315", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10489798": { "compartment": "compartment_7660", "id": "reaction_10489798", "reactome": "R-DME-8865320", "name": "CBFB binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489782", "species_10489792" ], "products": [ "species_10489794" ], "modifiers": [ [ "species_10489796", "inhibitor" ] ], "additional_components": [ "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q7KUZ5", "FBgn0010315" ] }, "reaction_10466198": { "compartment": "compartment_876", "id": "reaction_10466198", "reactome": "R-DME-2534365", "name": "Slo3 Potassium Transport", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10466195", "catalyst" ] ], "additional_components": [ "Q03720", "FBgn0003429" ] }, "reaction_10449198": { "compartment": "compartment_876", "id": "reaction_10449198", "reactome": "R-DME-432010", "name": "Aquaporin-1 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10449195", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872" ] }, "reaction_10449388": { "compartment": "compartment_70101", "id": "reaction_10449388", "reactome": "R-DME-432232", "name": "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10449372" ], "products": [ "species_29370", "species_10449386" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "D3DMU9", "FBgn0033635", "D3DMU9", "FBgn0033635", "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10449412": { "compartment": "compartment_876", "id": "reaction_10449412", "reactome": "R-DME-432237", "name": "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449386" ], "products": [ "species_10449231" ], "modifiers": [ [ "species_10449409", "catalyst" ] ], "additional_components": [ "D3DMU9", "FBgn0033635", "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884", "O18335", "FBgn0015790", "species_29438", "Q9VWS3", "FBgn0027335", "A1Z6Z8", "FBgn0261397" ] }, "reaction_10449251": { "compartment": "compartment_876", "id": "reaction_10449251", "reactome": "R-DME-432067", "name": "Aquaporin-4 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10449248", "catalyst" ] ], "additional_components": [ "Q9W1M4", "FBgn0034882", "Q9W1M2", "FBgn0034884", "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "D3DMU9", "FBgn0033635" ] }, "reaction_10449234": { "compartment": "compartment_876", "id": "reaction_10449234", "reactome": "R-DME-432065", "name": "p-S256-Aquaporin-2 passively transports water into cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10449231", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884" ] }, "reaction_10449200": { "compartment": "compartment_876", "id": "reaction_10449200", "reactome": "R-DME-432054", "name": "Aquaporin-1 passively transports water out of cell", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10449195", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872" ] }, "reaction_10432557": { "compartment": "compartment_70101", "id": "reaction_10432557", "reactome": "R-DME-75886", "name": "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76114" ], "products": [ "species_76194", "species_76112" ], "modifiers": [ [ "species_10432552", "catalyst" ] ], "additional_components": [ "FBgn0027579" ] }, "reaction_10432635": { "compartment": "compartment_70101", "id": "reaction_10432635", "reactome": "R-DME-75900", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10432632", "catalyst" ] ], "additional_components": [ "Q960U8", "FBgn0004797" ] }, "reaction_10484777": { "compartment": "compartment_12045", "id": "reaction_10484777", "reactome": "R-DME-6800334", "name": "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6800352", "species_1500578" ], "products": [ "species_76103", "species_76194" ], "modifiers": [ [ "species_10484774", "catalyst" ] ], "additional_components": [ "Q7JYK2", "FBgn0033214", "Q7K1C2", "FBgn0033215", "A1Z739", "FBgn0033216" ] }, "reaction_10453385": { "compartment": "compartment_70101", "id": "reaction_10453385", "reactome": "R-DME-549192", "name": "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_75967", "species_76103" ], "products": [ "species_549167", "species_76194" ], "modifiers": [ [ "species_10453382", "catalyst" ] ], "additional_components": [ "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216", "Q7K1C2", "FBgn0033215" ] }, "reaction_10432581": { "compartment": "compartment_70101", "id": "reaction_10432581", "reactome": "R-DME-75887", "name": "Conversion of Glycerol to Glycerol-3-phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76116" ], "products": [ "species_29370", "species_76114" ], "modifiers": [ [ "species_10432578", "catalyst" ] ], "additional_components": [ "Q7JY99", "FBgn0033673" ] }, "reaction_10432625": { "compartment": "compartment_70101", "id": "reaction_10432625", "reactome": "R-DME-75899", "name": "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76108", "species_29356" ], "products": [ "species_29372", "species_76103" ], "modifiers": [ [ "species_10432618", "catalyst" ] ], "additional_components": [ "FBgn0263593" ] }, "reaction_10487894": { "compartment": "compartment_70101", "id": "reaction_10487894", "reactome": "R-DME-8848339", "name": "PNPLA5 hydrolyzes TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_549167" ], "products": [ "species_8876730", "species_76103" ], "modifiers": [ [ "species_10487891", "catalyst" ] ], "additional_components": [ "Q9VXY8", "FBgn0030607", "E1JI03", "FBgn0036449" ] }, "reaction_10471590": { "compartment": "compartment_70101", "id": "reaction_10471590", "reactome": "R-DME-5334794", "name": "FABPs bind LCFAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8876730", "species_10471582" ], "products": [ "species_10471588" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_8954142" ] }, "reaction_10439494": { "compartment": "compartment_5460", "id": "reaction_10439494", "reactome": "R-DME-188467", "name": "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_188458" ], "products": [ "species_31649", "species_188451" ], "modifiers": [ [ "species_10439491", "catalyst" ] ], "additional_components": [ "FBgn0022160" ] }, "reaction_209331": { "compartment": "compartment_70101", "id": "reaction_209331", "reactome": "R-DME-209331", "name": "Formation of the 'scaffold complex'", "reversible": "false", "notes": "The kinesin-related protein, Costal2 (COS), forms a microtubule-associated 'scaffold complex' with Cubitus Interruptus (CI) and the Ser/Thr protein kinase Fused (FU). CI also associates directly with the Supressor of Fused (SU(FU)) protein in a separate complex. Complexes containing CI, COS, FU and SU(FU) are detectable but rare. The Ser/Thr protein kinases: Protein kinase A (PKA-C1), Shaggy (SGG), Casein kinase I alpha (CKIalpha), and Casein kinase I epsilon (DCO) all bind to the scaffold protein COS.", "reactants": [ "species_206046", "species_205832", "species_205931", "species_205716", "species_205872", "species_205729", "species_206210" ], "products": [ "species_206721" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P23647", "Phospho FU", "P18431", "sgg", "P12370", "Pka-C1", "O16844", "Phospho (2 sites) COS", "P19538", "ci" ] }, "reaction_216136": { "compartment": "compartment_70101", "id": "reaction_216136", "reactome": "R-DME-216136", "name": "Formation of the CI:SU(FU) complex", "reversible": "false", "notes": "Cubitus Interruptus (CI) forms a separate complex with the Supressor of Fused (SU(FU)) protein.", "reactants": [ "species_206046", "species_206064" ], "products": [ "species_206802" ], "modifiers": [], "additional_components": [ "Q27279", "Phospho SU(FU)", "P19538", "ci" ] }, "reaction_209252": { "compartment": "compartment_7660", "id": "reaction_209252", "reactome": "R-DME-209252", "name": "CI75 inhibits transcription", "reversible": "false", "notes": "Upon arrival in the nucleus, truncated Cubitus Interruptus (CI75) represses transcription. Sensitive target genes include hh and dpp, but not ptc and repression depends on direct DNA-binding sites for CI75.", "reactants": [ "species_205741" ], "products": [ "species_205741" ], "modifiers": [], "additional_components": [] }, "reaction_209370": { "compartment": "compartment_13231", "id": "reaction_209370", "reactome": "R-DME-209370", "name": "CI75 transports from the cytosol to the nucleus", "reversible": "false", "notes": "Truncated Cubitus Interruptus (CI75) translocates from the cytosol to the nucleus.", "reactants": [ "species_206171" ], "products": [ "species_205741" ], "modifiers": [], "additional_components": [] }, "reaction_209313": { "compartment": "compartment_70101", "id": "reaction_209313", "reactome": "R-DME-209313", "name": "Autocleavage of HH", "reversible": "false", "notes": "The autoprocessing event results in cleavage of Hedgehog (HH) between Gly207 and Cys208, coupled to the covalent addition of cholesterol to Gly207 via an ester linkage to form N-HH.", "reactants": [ "species_176478", "species_205973" ], "products": [ "species_206216", "species_206215" ], "modifiers": [], "additional_components": [] }, "reaction_209271": { "compartment": "compartment_876", "id": "reaction_209271", "reactome": "R-DME-209271", "name": "N-HH moves from the cytosol to the extracellular region", "reversible": "false", "notes": "With the help of the transmembrane protein Dispatched (DISP), N-HH is secreted from the cytosol to the extracellular region.", "reactants": [ "species_206055", "species_206215" ], "products": [ "species_206055", "species_205888" ], "modifiers": [], "additional_components": [] }, "reaction_209272": { "compartment": "compartment_984", "id": "reaction_209272", "reactome": "R-DME-209272", "name": "N-HH binds to the transmembrane HSPG proteins", "reversible": "false", "notes": "N-HH movement between cells is facilitated by the glypicans aka heparan sulphate proteoglycan proteins (HSPGs), Dally (DALLY) and Dally-like protein (DLP) which require heparan sulphate modification by the Exostosin (EXT) family proteins tout-velu (TTV), brother of tout-velu (BOTV) and sister of tout-velu (EXT2) for this purpose. N-HH can form multimers, associated with enhanced movement of vertebrate Sonic Hedgehog, and can associate with lipophorin-containing lipophorin particles which appear to enhance N-HH movement. The protein Shifted (SHF) also facilitates HH movement.", "reactants": [ "species_205888", "species_206547" ], "products": [ "species_207018" ], "modifiers": [], "additional_components": [ "Q24114", "dally", "Q9GPL5", "DLP", "Q24114", "dally", "Q9GPL5", "DLP", "Q02936", "hh" ] }, "reaction_209357": { "compartment": "compartment_70101", "id": "reaction_209357", "reactome": "R-DME-209357", "name": "N-HH is palmitoylated by RASP", "reversible": "false", "notes": "After removal of an N-terminal signal sequence, RASP, a protein-cysteine N-palmitoyltransferase, palmitoylates the new N-terminus (CGPGR..) via a thiol intermediate that resolves into a stable amide linkage. Palmitoylation efficiency is increased by prior addition of cholesterol at the C-terminus.", "reactants": [ "species_76168", "species_206215" ], "products": [ "species_206215" ], "modifiers": [ [ "species_205927", "catalyst" ] ], "additional_components": [] }, "reaction_209185": { "compartment": "compartment_876", "id": "reaction_209185", "reactome": "R-DME-209185", "name": "Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for monomeric peptidoglycans (PGN). However, when monomeric PGN binds to PGRP-LCx receptor primarily through its elongated stem peptide, the unique disaccharide GlcNAc-MurNAc(anhydro) residues of the ligand are then presented by PGRP-LCx receptor in such a way as to make favourable interactions with the PGRP-LCa receptor ectodomain. The receptors are now in close proximity and can heterodimerise.", "reactants": [ "species_205720", "species_206681" ], "products": [ "species_206990" ], "modifiers": [], "additional_components": [ "Q9GNK5-2", "PGRP-LCx", "species_214401", "species_214401", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_209158": { "compartment": "compartment_876", "id": "reaction_209158", "reactome": "R-DME-209158", "name": "Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane", "reversible": "false", "notes": "The binding of polymeric peptidoglycan (PGN) to PGRP-LCx receptor results in adjacent PGRP-LCx receptors additionally binding to PGN. This brings the receptors into close enough proximity for them to multimerise.", "reactants": [ "species_207039", "species_205794" ], "products": [ "species_354316" ], "modifiers": [], "additional_components": [ "Q9GNK5-2", "PGRP-LCx", "species_214401", "CHEBI:28881", "species_1678743", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx" ] }, "reaction_214395": { "compartment": "compartment_70101", "id": "reaction_214395", "reactome": "R-DME-214395", "name": "Monomeric PGN bound PGRP-LE oligomerises in the cytosol", "reversible": "false", "notes": "The binding of monomeric peptidoglycans (PGN) to PGRP-LE receptor results in adjacent PGRP-LE receptors binding to the complex and forming a PGRP-LE oligomer.", "reactants": [ "species_214396" ], "products": [ "species_354246" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "species_214401", "Q9VXN9", "PGRP-LE" ] }, "reaction_10430841": { "compartment": "compartment_70101", "id": "reaction_10430841", "reactome": "R-DME-72676", "name": "eIF3 and eIF1A bind to the 40S subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430368", "species_10430435", "species_10430440" ], "products": [ "species_10430839" ], "modifiers": [], "additional_components": [ "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "FBgn0026250", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136" ] }, "reaction_10430837": { "compartment": "compartment_70101", "id": "reaction_10430837", "reactome": "R-DME-72673", "name": "Release of 40S and 60S subunits from the 80S ribosome ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430818", "species_10430440" ], "products": [ "species_10430816", "species_10430368", "species_10430440" ], "modifiers": [], "additional_components": [ "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "FBgn0026250", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "FBgn0026250" ] }, "reaction_10430527": { "compartment": "compartment_70101", "id": "reaction_10430527", "reactome": "R-DME-72622", "name": "Release of eIF4E from the inactive eIF4E:4E-BP complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430525" ], "products": [ "species_10430485", "species_10430523" ], "modifiers": [], "additional_components": [ "Q9XZ56", "Thor", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709" ] }, "reaction_10430529": { "compartment": "compartment_70101", "id": "reaction_10430529", "reactome": "R-DME-72631", "name": "Formation of the cap-binding eIF4F complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430497", "species_10430485", "species_10430474" ], "products": [ "species_10430499" ], "modifiers": [], "additional_components": [ "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q02748", "FBgn0001942", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10430568": { "compartment": "compartment_70101", "id": "reaction_10430568", "reactome": "R-DME-72670", "name": "Formation of eIF2:GDP:eIF2B intermediate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430564", "species_10430517" ], "products": [ "species_10430566" ], "modifiers": [], "additional_components": [ "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29420", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "species_29420" ] }, "reaction_10430848": { "compartment": "compartment_70101", "id": "reaction_10430848", "reactome": "R-DME-72722", "name": "eIF2 activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10430566" ], "products": [ "species_29420", "species_10430564", "species_10430459" ], "modifiers": [ [ "species_10430564", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "species_29420", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VAD4", "FBgn0039726", "Q9W541", "FBgn0023512", "Q9W1Q8", "FBgn0034858", "O76863", "FBgn0024996", "A1ZA22", "FBgn0034029" ] }, "reaction_10430835": { "compartment": "compartment_70101", "id": "reaction_10430835", "reactome": "R-DME-72672", "name": "The 60S subunit joins the translation initiation complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430816", "species_10430515", "species_10430825" ], "products": [ "species_10430827" ], "modifiers": [], "additional_components": [ "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9VZP5", "FBgn0026259", "species_29438", "Q9VZP5", "FBgn0026259", "species_29438", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897" ] }, "reaction_10430833": { "compartment": "compartment_70101", "id": "reaction_10430833", "reactome": "R-DME-72671", "name": "eIF5B:GTP is hydrolyzed and released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430827" ], "products": [ "species_29372", "species_10430829", "species_10430831" ], "modifiers": [], "additional_components": [ "Q9VZP5", "FBgn0026259", "species_29438", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VZP5", "FBgn0026259", "species_29420", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897" ] }, "reaction_10435566": { "compartment": "compartment_70101", "id": "reaction_10435566", "reactome": "R-DME-156826", "name": "Dissociation of L13a from the 60s ribosomal subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430816" ], "products": [ "species_10430608", "species_10435564" ], "modifiers": [], "additional_components": [ "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "FBgn0037351", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897" ] }, "reaction_10435562": { "compartment": "compartment_70101", "id": "reaction_10435562", "reactome": "R-DME-156823", "name": "Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435553", "species_10435558" ], "products": [ "species_10435560" ], "modifiers": [], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P21187", "FBgn0265297", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0037351", "Q9VNE9", "FBgn0037351", "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "species_29438", "Q9VEA1", "FBgn0026250", "Q9U9Q4", "FBgn0022023", "Q9VTU4", "FBgn0036258", "Q0E940", "FBgn0034237", "Q9W2D9", "FBgn0034654", "Q9VN50", "FBgn0037270", "O77410", "FBgn0025582", "Q9W4X7", "FBgn0029629", "A1ZAX1", "FBgn0034258", "O02195", "FBgn0015834", "Q9VCK0", "FBgn0040227", "Q7K550", "FBgn0027619", "Q9VN25", "FBgn0037249", "Q7JVI3", "FBgn0033902", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "P21187", "FBgn0265297", "X2JC79", "FBgn0262734", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10447275": { "compartment": "compartment_7660", "id": "reaction_10447275", "reactome": "R-DME-400204", "name": "PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_422139", "species_10445291", "species_10440428" ], "products": [ "species_10447235" ], "modifiers": [], "additional_components": [ "FBgn0000568", "FBgn0003964", "P20153", "FBgn0003964", "P13055", "FBgn0000568" ] }, "reaction_10447273": { "compartment": "compartment_7660", "id": "reaction_10447273", "reactome": "R-DME-400183", "name": "PPARA:RXRA heterodimer recruits corepressors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447233", "species_10447235", "species_10447226", "species_10447231" ], "products": [ "species_10447237" ], "modifiers": [], "additional_components": [ "FBgn0263933", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "FBgn0025825", "FBgn0263933", "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "P20153", "FBgn0003964", "P13055", "FBgn0000568" ] }, "reaction_10447271": { "compartment": "compartment_7660", "id": "reaction_10447271", "reactome": "R-DME-400143", "name": "Fatty acid ligands activate PPARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447237", "species_10447259", "species_10447263" ], "products": [ "species_10447269", "species_10447226", "species_10447261" ], "modifiers": [], "additional_components": [ "Q95RJ9", "FBgn0263933", "Q7KTS4", "FBgn0025825", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "Q9VH48", "FBgn0037770", "M9MS40", "FBgn0261617", "Q9VEA4", "FBgn0266195", "M9ND53", "FBgn0041092", "Q9VP05", "FBgn0037109", "Q9VYG2", "FBgn0025463", "species_9661418", "Q8INK3", "FBgn0037913", "species_3632881", "CHEBI:28364", "CHEBI:27432", "CHEBI:17351", "species_422506", "Q95RJ9", "FBgn0263933", "Q9VH48", "FBgn0037770", "M9MS40", "FBgn0261617", "Q9VEA4", "FBgn0266195", "M9ND53", "FBgn0041092", "Q9VP05", "FBgn0037109", "Q9VYG2", "FBgn0025463", "species_9661418", "P20153", "FBgn0003964", "species_3632881", "CHEBI:28364", "CHEBI:27432", "CHEBI:17351", "species_422506", "P13055", "FBgn0000568", "FBgn0025825", "FBgn0037913" ] }, "reaction_10443214": { "compartment": "compartment_17960", "id": "reaction_10443214", "reactome": "R-DME-211904", "name": "CYP4F12 18-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_352318" ], "modifiers": [ [ "species_10443211", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS79", "FBgn0015033", "O46051", "FBgn0023541", "Q9VS78", "FBgn0035790", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q27589", "FBgn0011576", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "P33269", "FBgn0005670", "Q9VVN6", "FBgn0036778" ] }, "reaction_10443224": { "compartment": "compartment_17960", "id": "reaction_10443224", "reactome": "R-DME-211924", "name": "CYP4B1 12-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215075" ], "modifiers": [ [ "species_10443221", "catalyst" ] ], "additional_components": [ "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053" ] }, "reaction_10443253": { "compartment": "compartment_17960", "id": "reaction_10443253", "reactome": "R-DME-211983", "name": "CYP2J2 oxidises ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215062" ], "modifiers": [ [ "species_10443250", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34157", "species_2142739", "CHEBI:34490", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10433058": { "compartment": "compartment_17960", "id": "reaction_10433058", "reactome": "R-DME-76466", "name": "CYP4A11 12-hydroxylates DDCX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_33549", "species_113601" ], "products": [ "species_113519", "species_113564", "species_42373" ], "modifiers": [ [ "species_10433055", "catalyst" ] ], "additional_components": [ "Q9VXY0", "FBgn0030615", "Q9V557", "FBgn0033395", "Q9VLZ7", "FBgn0031925", "O46051", "FBgn0023541", "Q9VVN6", "FBgn0036778", "Q9V4T5", "FBgn0015034", "Q9VL92", "FBgn0015035", "Q9VS79", "FBgn0015033", "Q9V4T3", "FBgn0033292", "Q9VGH1", "FBgn0003312", "Q9VS78", "FBgn0035790", "Q27606", "FBgn0014469", "Q9V7G5", "FBgn0034053", "Q9VMS9", "FBgn0031693", "Q27589", "FBgn0011576", "Q9W011", "FBgn0035344", "Q9V559", "FBgn0033397", "Q9VMS8", "FBgn0031694", "P33269", "FBgn0005670", "Q9VYQ7", "FBgn0030367", "Q9V558", "FBgn0015037", "Q9VMS7", "FBgn0031695", "O46054", "FBgn0015036" ] }, "reaction_10465651": { "compartment": "compartment_5460", "id": "reaction_10465651", "reactome": "R-DME-2395517", "name": "NADPH transfers electrons to FDXR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113600", "species_10465647" ], "products": [ "species_113563", "species_10465645" ], "modifiers": [], "additional_components": [ "Q9V3T9", "FBgn0015582", "species_113596", "species_31649", "Q9V3T9", "FBgn0015582" ] }, "reaction_10465649": { "compartment": "compartment_5460", "id": "reaction_10465649", "reactome": "R-DME-2395512", "name": "FDXR transfers electrons to FDX1,2 (FDX1L)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10459056", "species_10465645" ], "products": [ "species_113529", "species_10459048", "species_10465647" ], "modifiers": [], "additional_components": [ "CHEBI:33737", "P37193", "FBgn0011769", "Q8SZA8", "FBgn0035529", "species_31649", "Q9V3T9", "FBgn0015582", "Q8SZA8", "FBgn0035529", "CHEBI:33738", "P37193", "FBgn0011769", "Q9V3T9", "FBgn0015582", "species_113596" ] }, "reaction_10459064": { "compartment": "compartment_5460", "id": "reaction_10459064", "reactome": "R-DME-1362416", "name": "Frataxin binds iron", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113531", "species_10459062" ], "products": [ "species_10459032" ], "modifiers": [], "additional_components": [ "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "Q9W385", "FBgn0030092", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "species_111793", "Q9W385", "FBgn0030092" ] }, "reaction_10491819": { "compartment": "compartment_5460", "id": "reaction_10491819", "reactome": "R-DME-8878815", "name": "Formation of 4Fe-4S cluster on ISCA1:ISCA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491798", "species_10491810" ], "products": [ "species_10491796", "species_10491812" ], "modifiers": [ [ "species_10491817", "catalyst" ] ], "additional_components": [ "Q8SXQ5", "FBgn0030584", "CHEBI:33739", "Q9VC65", "FBgn0039205", "Q8T3X9", "FBgn0026666", "FBgn0030584", "Q9VC65", "FBgn0039205", "Q8T3X9", "FBgn0026666", "CHEBI:49883", "FBgn0263606" ] }, "reaction_10459059": { "compartment": "compartment_5460", "id": "reaction_10459059", "reactome": "R-DME-1362408", "name": "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_379721", "species_10459048", "species_10459032" ], "products": [ "species_10459056", "species_10459050", "species_379697" ], "modifiers": [ [ "species_10459032", "catalyst" ], [ "species_10459048", "catalyst" ] ], "additional_components": [ "Q8SZA8", "FBgn0035529", "CHEBI:33738", "P37193", "FBgn0011769", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "species_111793", "Q9W385", "FBgn0030092", "CHEBI:33737", "P37193", "FBgn0011769", "Q8SZA8", "FBgn0035529", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "CHEBI:33739", "Q9W385", "FBgn0030092", "O46098", "FBgn0013432", "Q9VHK6", "FBgn0037637", "Q9VKD3", "FBgn0032393", "species_111793", "Q9W385", "FBgn0030092", "Q8SZA8", "FBgn0035529", "CHEBI:33738", "P37193", "FBgn0011769" ] }, "reaction_10443243": { "compartment": "compartment_12045", "id": "reaction_10443243", "reactome": "R-DME-211966", "name": "CYP2D6 4-hydroxylates debrisoquine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_211993", "species_113601" ], "products": [ "species_113519", "species_113564", "species_211952" ], "modifiers": [ [ "species_10432787", "catalyst" ] ], "additional_components": [ "Q95078", "FBgn0010383", "Q9VWR5", "FBgn0004959" ] }, "reaction_10432790": { "compartment": "compartment_12045", "id": "reaction_10432790", "reactome": "R-DME-76456", "name": "O-atom dealkylation of dextromethorphan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_39703", "species_113601" ], "products": [ "species_143501", "species_113519", "species_113564", "species_76455" ], "modifiers": [ [ "species_10432787", "catalyst" ] ], "additional_components": [ "Q95078", "FBgn0010383", "Q9VWR5", "FBgn0004959" ] }, "reaction_10465550": { "compartment": "compartment_876", "id": "reaction_10465550", "reactome": "R-DME-2327746", "name": "FN1 aggregation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442018", "species_10442026" ], "products": [ "species_10465548" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "species_266099", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10442028": { "compartment": "compartment_876", "id": "reaction_10442028", "reactome": "R-DME-202723", "name": "Integrin alpha5beta1 binds FN1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442020", "species_10442024", "species_266099" ], "products": [ "species_10442026" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "species_266099", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163" ] }, "reaction_10466200": { "compartment": "compartment_984", "id": "reaction_10466200", "reactome": "R-DME-2545196", "name": "FN1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442018" ], "products": [ "species_10442020" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163" ] }, "reaction_10498752": { "compartment": "compartment_7660", "id": "reaction_10498752", "reactome": "R-DME-9708430", "name": "XPO1 (CRM1) binds to BACH1:Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498740", "species_10437629" ], "products": [ "species_10498742" ], "modifiers": [], "additional_components": [ "Q9VYJ8", "FBgn0030417", "FBgn0020497", "Q9TVM2", "FBgn0020497", "Q9VYJ8", "FBgn0030417" ] }, "reaction_10455099": { "compartment": "compartment_876", "id": "reaction_10455099", "reactome": "R-DME-917870", "name": "SLC46A1 transports hemes from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310" ], "products": [ "species_9707308" ], "modifiers": [ [ "species_10441404", "catalyst" ] ], "additional_components": [ "species_71185", "B7YZU3", "FBgn0033387", "Q8INF8", "FBgn0051321", "Q9VY22", "FBgn0030576", "A1Z7R6", "FBgn0033388", "Q1EC10", "FBgn0050345", "Q9VA14", "FBgn0039817", "Q0E8E1", "FBgn0260388", "Q961H2", "FBgn0050344" ] }, "reaction_10498750": { "compartment": "compartment_70101", "id": "reaction_10498750", "reactome": "R-DME-9708423", "name": "XPO1:BACH1:Hemes are transported out of the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498742" ], "products": [ "species_10498748" ], "modifiers": [], "additional_components": [ "Q9TVM2", "FBgn0020497", "Q9VYJ8", "FBgn0030417", "Q9VYJ8", "FBgn0030417", "Q9TVM2", "FBgn0020497" ] }, "reaction_10458287": { "compartment": "compartment_70101", "id": "reaction_10458287", "reactome": "R-DME-1247665", "name": "SLC4A1 exchanges cytosolic Cl- for extracellular HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_425425", "species_352022" ], "products": [ "species_188972", "species_111627" ], "modifiers": [ [ "species_10458178", "catalyst" ] ], "additional_components": [ "Q9VT48", "FBgn0036043" ] }, "reaction_10458285": { "compartment": "compartment_70101", "id": "reaction_10458285", "reactome": "R-DME-1247649", "name": "AQP1 tetramer transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10449195", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872" ] }, "reaction_10458236": { "compartment": "compartment_984", "id": "reaction_10458236", "reactome": "R-DME-1237059", "name": "CA4:Zn2+ dehydrates HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10458231", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VH26", "FBgn0037788" ] }, "reaction_10458283": { "compartment": "compartment_70101", "id": "reaction_10458283", "reactome": "R-DME-1247645", "name": "RHAG transports CO2 from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113528" ], "products": [ "species_1237009" ], "modifiers": [ [ "species_10450042", "catalyst" ] ], "additional_components": [ "FBgn0028699" ] }, "reaction_10459562": { "compartment": "compartment_70101", "id": "reaction_10459562", "reactome": "R-DME-1475436", "name": "CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10459557", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10458234": { "compartment": "compartment_984", "id": "reaction_10458234", "reactome": "R-DME-1237047", "name": "CA4:Zn2+ hydrates CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10458231", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VH26", "FBgn0037788" ] }, "reaction_10459560": { "compartment": "compartment_70101", "id": "reaction_10459560", "reactome": "R-DME-1475435", "name": "CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10459557", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10457039": { "compartment": "compartment_70101", "id": "reaction_10457039", "reactome": "R-DME-983156", "name": "Polyubiquitination of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456947", "species_113592", "species_10456941" ], "products": [ "species_111294", "species_10456939", "species_10457005", "species_76577" ], "modifiers": [ [ "species_10456947", "catalyst" ] ], "additional_components": [ "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10457007": { "compartment": "compartment_70101", "id": "reaction_10457007", "reactome": "R-DME-983147", "name": "Release of E3 from polyubiquitinated substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457005" ], "products": [ "species_983123", "species_10456828" ], "modifiers": [], "additional_components": [ "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653" ] }, "reaction_10457036": { "compartment": "compartment_70101", "id": "reaction_10457036", "reactome": "R-DME-983153", "name": "E1 mediated ubiquitin activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457028", "species_113592", "species_29926", "species_10426987" ], "products": [ "species_111294", "species_10457030", "species_29926", "species_76577" ], "modifiers": [ [ "species_10457028", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10457033": { "compartment": "compartment_70101", "id": "reaction_10457033", "reactome": "R-DME-983152", "name": "Transfer of ubiquitin from E1 to E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457030", "species_10456939" ], "products": [ "species_10457028", "species_10456941" ], "modifiers": [ [ "species_10456939", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436" ] }, "reaction_10456950": { "compartment": "compartment_70101", "id": "reaction_10456950", "reactome": "R-DME-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10456943" ], "products": [ "species_111294", "species_10456947", "species_10456939", "species_76577" ], "modifiers": [ [ "species_10456828", "catalyst" ] ], "additional_components": [ "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653" ] }, "reaction_10457186": { "compartment": "compartment_70101", "id": "reaction_10457186", "reactome": "R-DME-983162", "name": "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983036" ], "products": [ "species_983032", "species_8942986" ], "modifiers": [ [ "species_10457183", "catalyst" ] ], "additional_components": [ "Q9V6K1", "FBgn0020370", "X2JEJ0", "FBgn0030038", "Q8IRH1", "FBgn0261243", "Q0KI25", "FBgn0039064", "Q0KI00", "FBgn0263236", "Q9W2S8", "FBgn0030222", "Q9W2S7", "FBgn0030223", "Q9W1S1", "FBgn0046253", "Q9VTL4", "FBgn0036186", "Q9VJN2", "FBgn0028935", "Q9VD87", "FBgn0038897", "Q9VAM2", "FBgn0039656", "Q95SR0", "FBgn0051445", "Q8SWX4", "FBgn0051343", "Q8MRN5", "FBgn0051343" ] }, "reaction_10457041": { "compartment": "compartment_70101", "id": "reaction_10457041", "reactome": "R-DME-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983035", "species_10456828", "species_10456941" ], "products": [ "species_10456943" ], "modifiers": [], "additional_components": [ "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25153", "FBgn0004436", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W3V3", "FBgn0029911", "Q9VN58", "FBgn0260794", "Q24311", "Cul1", "Q23985", "dx", "P21461", "FBgn0003410", "Q9VY46", "FBgn0030555", "A1Z6E0", "FBgn0026238", "Q9XZ21", "FBgn0086129", "M9MRI4", "FBgn0051721", "Q9VVI3", "FBgn0259174", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "Q9VSB2", "FBgn0052369", "X2JF73", "FBgn0030674", "Q9VJ14", "FBgn0086442", "Q9V853", "FBgn0029006", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VX91", "FBgn0030809", "Q86B79", "FBgn0004395", "Q7JR34", "FBgn0053144", "E8NHA2", "FBgn0035207", "Q9VHI7", "FBgn0037653" ] }, "reaction_10457009": { "compartment": "compartment_70101", "id": "reaction_10457009", "reactome": "R-DME-983150", "name": "Proteasomal cleavage of substrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983123" ], "products": [ "species_983032", "species_10426987", "species_8942986", "species_983036" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_209377": { "compartment": "compartment_984", "id": "reaction_209377", "reactome": "R-DME-209377", "name": "Polymeric PGN binds to PGRP-LCx at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCx, receptor exhibits strong affinity for both polymeric and monomeric peptidoglycans.", "reactants": [ "species_206912", "species_205794" ], "products": [ "species_207039" ], "modifiers": [], "additional_components": [ "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "species_214401", "CHEBI:28881", "species_1678743" ] }, "reaction_209355": { "compartment": "compartment_984", "id": "reaction_209355", "reactome": "R-DME-209355", "name": "Monomeric PGN binds to PGRP-LCx at the plasma membrane", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for peptidoglycans (PGN). However, PGRP-LCx receptor exhibits strong affinity for them.", "reactants": [ "species_205686", "species_205794" ], "products": [ "species_206681" ], "modifiers": [], "additional_components": [ "Q9GNK5-2", "PGRP-LCx", "species_214401" ] }, "reaction_214410": { "compartment": "compartment_70101", "id": "reaction_214410", "reactome": "R-DME-214410", "name": "Monomeric PGN binds to PGRP-LE in the cytosol", "reversible": "false", "notes": "Peptidoglycan recognition protein, PGRP-LE receptor contains no predicted transmembrane domain or signal sequence and so is predicted to be an intracellular receptor. The recognition of the monomeric diaminopimelic acid (DAP)-type peptidoglycan (PGN) tracheal cytotoxin, TCT by PGRP-LE occurs intracellularly. However, it is postulated that the PGRP domain of a truncated PGRP-LE can also function outside the cell in a CD14-like manner by presenting DAP-type PGNs to cell surface PGRP-LC receptors.", "reactants": [ "species_214412", "species_214401" ], "products": [ "species_214396" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE" ] }, "reaction_214418": { "compartment": "compartment_70101", "id": "reaction_214418", "reactome": "R-DME-214418", "name": "REL binds to monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The NF-kappaB orthologue, Relish, binds to the caspase-8 orthologue, DREDD.", "reactants": [ "species_214404", "species_206135" ], "products": [ "species_214406" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4" ] }, "reaction_209244": { "compartment": "compartment_70101", "id": "reaction_209244", "reactome": "R-DME-209244", "name": "REL binds to DREDD in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The NF-kappaB orthologue, Relish, binds to the caspase-8 orthologue, DREDD.", "reactants": [ "species_354317", "species_206135" ], "products": [ "species_354323" ], "modifiers": [], "additional_components": [ "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_209221": { "compartment": "compartment_70101", "id": "reaction_209221", "reactome": "R-DME-209221", "name": "Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Upon ligand binding and receptor multimerisation at the plasma membrane, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the cytoplasmic part of the receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.", "reactants": [ "species_354313", "species_205887", "species_205876", "species_206183" ], "products": [ "species_354317" ], "modifiers": [], "additional_components": [ "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa" ] }, "reaction_214405": { "compartment": "compartment_70101", "id": "reaction_214405", "reactome": "R-DME-214405", "name": "Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "Upon monomeric peptidoglycan (PGN) binding and receptor multimerisation in the cytosol, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the PGRP-LE receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.", "reactants": [ "species_205887", "species_205876", "species_206183", "species_354246" ], "products": [ "species_214404" ], "modifiers": [], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4" ] }, "reaction_10433119": { "compartment": "compartment_7660", "id": "reaction_10433119", "reactome": "R-DME-77077", "name": "Capping complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433113", "species_72084", "species_29428" ], "products": [ "species_10433117" ], "modifiers": [], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433149": { "compartment": "compartment_7660", "id": "reaction_10433149", "reactome": "R-DME-77095", "name": "Recognition and binding of the mRNA cap by the cap-binding complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429248", "species_10429169" ], "products": [ "species_10429250" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10433131": { "compartment": "compartment_7660", "id": "reaction_10433131", "reactome": "R-DME-77081", "name": "Formation of the CE:GMP intermediate complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433121", "species_113571" ], "products": [ "species_10433128", "species_111349" ], "modifiers": [ [ "species_10433121", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "species_5696194", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433147": { "compartment": "compartment_7660", "id": "reaction_10433147", "reactome": "R-DME-77094", "name": "Formation of cap binding complex (CBC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429162", "species_10429167" ], "products": [ "species_10429169" ], "modifiers": [], "additional_components": [ "FBgn0022943", "FBgn0022942", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10433115": { "compartment": "compartment_7660", "id": "reaction_10433115", "reactome": "R-DME-77073", "name": "SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433105", "species_10433089", "species_10433111" ], "products": [ "species_10433113" ], "modifiers": [], "additional_components": [ "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "FBgn0040273", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433145": { "compartment": "compartment_7660", "id": "reaction_10433145", "reactome": "R-DME-77090", "name": "Methylation of GMP-cap by RNA Methyltransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77087", "species_10433138" ], "products": [ "species_10429248", "species_77502", "species_10431174", "species_10433142", "species_10433111" ], "modifiers": [ [ "species_10433138", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VY44", "FBgn0030556", "Q9VJQ4", "FBgn0286027", "FBgn0040273", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433095": { "compartment": "compartment_7660", "id": "reaction_10433095", "reactome": "R-DME-77069", "name": "RNA Polymerase II CTD (phosphorylated) binds to CE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433093", "species_10433087" ], "products": [ "species_10433089" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "FBgn0030556", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10433124": { "compartment": "compartment_7660", "id": "reaction_10433124", "reactome": "R-DME-77078", "name": "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433117" ], "products": [ "species_113550", "species_10433121" ], "modifiers": [ [ "species_10433117", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433140": { "compartment": "compartment_7660", "id": "reaction_10433140", "reactome": "R-DME-77085", "name": "Dissociation of transcript with 5'-GMP from GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433133" ], "products": [ "species_10433138" ], "modifiers": [], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027" ] }, "reaction_10433091": { "compartment": "compartment_7660", "id": "reaction_10433091", "reactome": "R-DME-77068", "name": "Activation of GT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433089" ], "products": [ "species_10433089" ], "modifiers": [], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10433136": { "compartment": "compartment_7660", "id": "reaction_10433136", "reactome": "R-DME-77083", "name": "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433128" ], "products": [ "species_10433133" ], "modifiers": [ [ "species_10433128", "catalyst" ] ], "additional_components": [ "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "species_5696194", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "Q9VY44", "FBgn0030556", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9V460", "FBgn0040273", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VJQ4", "FBgn0286027", "species_5696194" ] }, "reaction_10479695": { "compartment": "compartment_984", "id": "reaction_10479695", "reactome": "R-DME-6785213", "name": "LIPC dimer binds heparin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1604784", "species_10478382" ], "products": [ "species_10478384" ], "modifiers": [], "additional_components": [ "Q9VB91", "FBgn0039473", "A1ZAL5", "FBgn0034166", "Q9VX70", "FBgn0265267", "Q9VB90", "FBgn0039474", "Q9VX69", "FBgn0030828", "Q9VB89", "FBgn0039475", "Q9VX01", "FBgn0030884", "Q9VB88", "FBgn0039476", "Q9VU78", "FBgn0036367", "Q7K3Z8", "FBgn0032029", "Q9VRW5", "FBgn0035697", "Q4V566", "FBgn0085476", "Q9VLU1", "FBgn0031976", "Q0E8T1", "FBgn0250847", "Q9VJH1", "FBgn0032612", "P06607", "FBgn0004047", "Q9VEY9", "FBgn0038398", "P02844", "FBgn0005391", "Q9VBQ2", "FBgn0039344", "P02843", "FBgn0004045", "Q9VB94", "FBgn0039470", "M9NFL7", "FBgn0036977", "Q9W448", "FBgn0029831", "Q9VB93", "FBgn0039471", "M9MRT1", "FBgn0032289", "Q9W304", "FBgn0030162", "Q9VB92", "FBgn0039472", "A8DYT7", "FBgn0085477", "Q9VZN6", "FBgn0035453", "Q9VB91", "FBgn0039473", "A1ZAL5", "FBgn0034166", "Q9VX70", "FBgn0265267", "Q9VB90", "FBgn0039474", "Q9VX69", "FBgn0030828", "Q9VB89", "FBgn0039475", "Q9VX01", "FBgn0030884", "Q9VB88", "FBgn0039476", "Q9VU78", "FBgn0036367", "Q7K3Z8", "FBgn0032029", "Q9VRW5", "FBgn0035697", "Q4V566", "FBgn0085476", "Q9VLU1", "FBgn0031976", "Q0E8T1", "FBgn0250847", "Q9VJH1", "FBgn0032612", "P06607", "FBgn0004047", "Q9VEY9", "FBgn0038398", "P02844", "FBgn0005391", "Q9VBQ2", "FBgn0039344", "P02843", "FBgn0004045", "Q9VB94", "FBgn0039470", "M9NFL7", "FBgn0036977", "Q9W448", "FBgn0029831", "Q9VB93", "FBgn0039471", "M9MRT1", "FBgn0032289", "Q9W304", "FBgn0030162", "Q9VB92", "FBgn0039472", "A8DYT7", "FBgn0085477", "Q9VZN6", "FBgn0035453", "species_1604784" ] }, "reaction_10479623": { "compartment": "compartment_984", "id": "reaction_10479623", "reactome": "R-DME-6784861", "name": "HSPG binds LPL dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479619", "species_1678620" ], "products": [ "species_10479621" ], "modifiers": [], "additional_components": [ "Q9VB90", "FBgn0039474", "Q9VB89", "FBgn0039475", "Q9VB88", "FBgn0039476", "Q7K3Z8", "FBgn0032029", "Q4V566", "FBgn0085476", "Q0E8T1", "FBgn0250847", "P06607", "FBgn0004047", "P02844", "FBgn0005391", "P02843", "FBgn0004045", "M9NFL7", "FBgn0036977", "M9MRT1", "FBgn0032289", "A8DYT7", "FBgn0085477", "A1ZAL5", "FBgn0034166", "Q9W448", "FBgn0029831", "Q9W304", "FBgn0030162", "Q9VZN6", "FBgn0035453", "Q9VX70", "FBgn0265267", "Q9VX69", "FBgn0030828", "Q9VX01", "FBgn0030884", "Q9VU78", "FBgn0036367", "Q9VRW5", "FBgn0035697", "Q9VLU1", "FBgn0031976", "Q9VJH1", "FBgn0032612", "Q9VEY9", "FBgn0038398", "Q9VBQ2", "FBgn0039344", "Q9VB94", "FBgn0039470", "Q9VB93", "FBgn0039471", "Q9VB92", "FBgn0039472", "Q9VB91", "FBgn0039473", "species_1678620", "Q9VB90", "FBgn0039474", "Q9VB89", "FBgn0039475", "Q9VB88", "FBgn0039476", "Q7K3Z8", "FBgn0032029", "Q4V566", "FBgn0085476", "Q0E8T1", "FBgn0250847", "P06607", "FBgn0004047", "P02844", "FBgn0005391", "P02843", "FBgn0004045", "M9NFL7", "FBgn0036977", "M9MRT1", "FBgn0032289", "A8DYT7", "FBgn0085477", "A1ZAL5", "FBgn0034166", "Q9W448", "FBgn0029831", "Q9W304", "FBgn0030162", "Q9VZN6", "FBgn0035453", "Q9VX70", "FBgn0265267", "Q9VX69", "FBgn0030828", "Q9VX01", "FBgn0030884", "Q9VU78", "FBgn0036367", "Q9VRW5", "FBgn0035697", "Q9VLU1", "FBgn0031976", "Q9VJH1", "FBgn0032612", "Q9VEY9", "FBgn0038398", "Q9VBQ2", "FBgn0039344", "Q9VB94", "FBgn0039470", "Q9VB93", "FBgn0039471", "Q9VB92", "FBgn0039472", "Q9VB91", "FBgn0039473" ] }, "reaction_10478387": { "compartment": "compartment_984", "id": "reaction_10478387", "reactome": "R-DME-5694109", "name": "LIPC dimer hydrolyses TAG to DAG and FA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_171126" ], "products": [ "species_422024", "species_174675" ], "modifiers": [ [ "species_10478384", "catalyst" ] ], "additional_components": [ "Q9VB91", "FBgn0039473", "A1ZAL5", "FBgn0034166", "Q9VX70", "FBgn0265267", "Q9VB90", "FBgn0039474", "Q9VX69", "FBgn0030828", "Q9VB89", "FBgn0039475", "Q9VX01", "FBgn0030884", "Q9VB88", "FBgn0039476", "Q9VU78", "FBgn0036367", "Q7K3Z8", "FBgn0032029", "Q9VRW5", "FBgn0035697", "Q4V566", "FBgn0085476", "Q9VLU1", "FBgn0031976", "Q0E8T1", "FBgn0250847", "Q9VJH1", "FBgn0032612", "P06607", "FBgn0004047", "Q9VEY9", "FBgn0038398", "P02844", "FBgn0005391", "Q9VBQ2", "FBgn0039344", "P02843", "FBgn0004045", "Q9VB94", "FBgn0039470", "M9NFL7", "FBgn0036977", "Q9W448", "FBgn0029831", "Q9VB93", "FBgn0039471", "M9MRT1", "FBgn0032289", "Q9W304", "FBgn0030162", "Q9VB92", "FBgn0039472", "A8DYT7", "FBgn0085477", "Q9VZN6", "FBgn0035453", "species_1604784" ] }, "reaction_10435351": { "compartment": "compartment_984", "id": "reaction_10435351", "reactome": "R-DME-140806", "name": "SERPINC1 binds SERPINC1 activators", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435285", "species_9693058" ], "products": [ "species_10435349" ], "modifiers": [], "additional_components": [ "Q0E8V6", "FBgn0051902", "Q9VFC1", "FBgn0038299", "Q0E8C8", "FBgn0262057", "Q9VA48", "FBgn0039795", "Q9VWB4", "FBgn0036969", "A1Z6V5", "FBgn0024293", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q9VVW1", "FBgn0015586", "A1Z6R4", "FBgn0033113", "Q8SYY7", "FBgn0044011", "Q9VPH9", "FBgn0036970", "A1Z6R3", "FBgn0033112", "Q7YTY6", "FBgn0028988", "Q9VLZ8", "FBgn0083141", "A1Z6I3", "FBgn0263109", "Q7KA66", "FBgn0024294", "Q9VLV3", "FBgn0053121", "Q7K8Y5", "FBgn0265137", "Q9VLU4", "FBgn0031973", "Q7K508", "FBgn0033574", "Q9VLQ7", "FBgn0028987", "Q7JWX3", "FBgn0002930", "Q9VL44", "FBgn0032178", "Q7JV69", "FBgn0028983", "Q9VII7", "FBgn0028986", "Q4V3G2", "FBgn0034195", "Q9VH46", "FBgn0037772", "Q3HKQ3", "FBgn0052203", "Q9VFC2", "FBgn0028984", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902" ] }, "reaction_10472771": { "compartment": "compartment_984", "id": "reaction_10472771", "reactome": "R-DME-5591086", "name": "SERPINA5 binds activated protein C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472753", "species_10472767" ], "products": [ "species_10472769" ], "modifiers": [ [ "species_977180", "catalyst" ] ], "additional_components": [ "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178" ] }, "reaction_10496558": { "compartment": "compartment_984", "id": "reaction_10496558", "reactome": "R-DME-9015111", "name": "Factor Xa inhibitors binds Xa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9038743", "species_10496554" ], "products": [ "species_10496556" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016" ] }, "reaction_10465672": { "compartment": "compartment_984", "id": "reaction_10465672", "reactome": "R-DME-2396079", "name": "VTN binds Plasminogen activator inhibitor- 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443474", "species_10452309" ], "products": [ "species_10465670" ], "modifiers": [], "additional_components": [ "FBgn0024366", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "O46099", "FBgn0024366" ] }, "reaction_10466600": { "compartment": "compartment_984", "id": "reaction_10466600", "reactome": "R-DME-2681681", "name": "Tenascins C, R, (X, N) bind fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443451", "species_10465757" ], "products": [ "species_10466598" ], "modifiers": [], "additional_components": [ "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163" ] }, "reaction_10465811": { "compartment": "compartment_876", "id": "reaction_10465811", "reactome": "R-DME-2426471", "name": "VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443474", "species_10443447" ], "products": [ "species_10465809" ], "modifiers": [], "additional_components": [ "FBgn0024366", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "O46099", "FBgn0024366" ] }, "reaction_10465968": { "compartment": "compartment_984", "id": "reaction_10465968", "reactome": "R-DME-2467665", "name": "AGRN binds Beta amyloid fibril via GAG chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465960", "species_10465964" ], "products": [ "species_10465966" ], "modifiers": [], "additional_components": [ "FBgn0015773", "P14599", "FBgn0000108", "P14599", "FBgn0000108", "Q24567", "FBgn0015773" ] }, "reaction_10462495": { "compartment": "compartment_12045", "id": "reaction_10462495", "reactome": "R-DME-1981104", "name": "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10462488", "species_1650779" ], "products": [ "species_1650769", "species_159751", "species_10462492" ], "modifiers": [ [ "species_10462486", "catalyst" ] ], "additional_components": [ "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793" ] }, "reaction_10462527": { "compartment": "compartment_12045", "id": "reaction_10462527", "reactome": "R-DME-1981157", "name": "Glucosylation of collagen propeptide hydroxylysines", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462517", "species_173594" ], "products": [ "species_158602", "species_10462524" ], "modifiers": [ [ "species_10462484", "catalyst" ] ], "additional_components": [ "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147" ] }, "reaction_10462555": { "compartment": "compartment_17957", "id": "reaction_10462555", "reactome": "R-DME-2002401", "name": "Association of procollagen type XVIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462529" ], "products": [ "species_10462553" ], "modifiers": [], "additional_components": [ "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10493353": { "compartment": "compartment_17957", "id": "reaction_10493353", "reactome": "R-DME-8944257", "name": "Association of procollagen type XXIV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462830" ], "products": [ "species_10462854" ], "modifiers": [], "additional_components": [ "FBgn0038468", "Q9VEP4", "FBgn0038468" ] }, "reaction_10462622": { "compartment": "compartment_984", "id": "reaction_10462622", "reactome": "R-DME-2002428", "name": "Removal of fibrillar collagen N-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462581" ], "products": [ "species_10462607" ], "modifiers": [ [ "species_10462619", "catalyst" ] ], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468", "Q9VC47", "FBgn0004885", "P25723", "FBgn0003719" ] }, "reaction_10462520": { "compartment": "compartment_12045", "id": "reaction_10462520", "reactome": "R-DME-1981128", "name": "Galactosylation of collagen propeptide hydroxylysines by PLOD3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10462515" ], "products": [ "species_10462517", "species_158602" ], "modifiers": [ [ "species_10462484", "catalyst" ] ], "additional_components": [ "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147", "species_111793", "Q9VTH0", "FBgn0036147" ] }, "reaction_10462629": { "compartment": "compartment_984", "id": "reaction_10462629", "reactome": "R-DME-2002440", "name": "Removal of fibrillar collagen C-propeptides", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462607" ], "products": [ "species_10459392" ], "modifiers": [ [ "species_10462626", "catalyst" ] ], "additional_components": [ "Q9VEP4", "FBgn0038468", "Q9VEP4", "FBgn0038468", "Q9VC47", "FBgn0004885", "P25723", "FBgn0003719" ] }, "reaction_10462513": { "compartment": "compartment_17957", "id": "reaction_10462513", "reactome": "R-DME-1981120", "name": "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1981137", "species_10462506" ], "products": [ "species_158602", "species_10462510" ], "modifiers": [ [ "species_10462506", "catalyst" ] ], "additional_components": [ "Q8IPK4", "FBgn0051915", "Q8IPK4", "FBgn0051915", "Q8IPK4", "FBgn0051915" ] }, "reaction_10443439": { "compartment": "compartment_984", "id": "reaction_10443439", "reactome": "R-DME-216048", "name": "Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443380", "species_10443435" ], "products": [ "species_10443437" ], "modifiers": [], "additional_components": [ "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q9W4Y3", "FBgn0284408", "Q8IP51", "FBgn0261563", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q9W4Y3", "FBgn0284408", "Q8IP51", "FBgn0261563", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "Q27591", "FBgn0010395", "P11584", "FBgn0004657" ] }, "reaction_10469164": { "compartment": "compartment_876", "id": "reaction_10469164", "reactome": "R-DME-3907292", "name": "Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469158", "species_10469160" ], "products": [ "species_10469162" ], "modifiers": [], "additional_components": [ "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "Q9W4Y3", "FBgn0284408", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "Q9W4Y3", "FBgn0284408", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "O44386", "FBgn0286785", "P11584", "FBgn0004657" ] }, "reaction_10443932": { "compartment": "compartment_984", "id": "reaction_10443932", "reactome": "R-DME-349626", "name": "Integrin alpha2beta1 binds laminin-332", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443411", "species_10443928" ], "products": [ "species_10443930" ], "modifiers": [], "additional_components": [ "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P11046", "FBgn0261800", "Q9W4Y3", "FBgn0284408", "P15215", "FBgn0267348", "Q8IP51", "FBgn0261563", "Q00174", "FBgn0002526" ] }, "reaction_10443465": { "compartment": "compartment_984", "id": "reaction_10443465", "reactome": "R-DME-216058", "name": "Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443459", "species_10443461" ], "products": [ "species_10443463" ], "modifiers": [], "additional_components": [ "P11584", "FBgn0004657", "Q24247", "FBgn0004456", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "P11046", "FBgn0261800", "P15215", "FBgn0267348", "Q00174", "FBgn0002526", "Q8IP51", "FBgn0261563", "P11584", "FBgn0004657", "Q24247", "FBgn0004456" ] }, "reaction_10466975": { "compartment": "compartment_876", "id": "reaction_10466975", "reactome": "R-DME-2731074", "name": "Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463847", "species_10466971" ], "products": [ "species_10466973" ], "modifiers": [], "additional_components": [ "FBgn0010415", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P49415", "FBgn0010415" ] }, "reaction_10466987": { "compartment": "compartment_876", "id": "reaction_10466987", "reactome": "R-DME-2731141", "name": "Syndecan-1 binds fibronectin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463847", "species_10443451" ], "products": [ "species_10466985" ], "modifiers": [], "additional_components": [ "FBgn0010415", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P49415", "FBgn0010415" ] }, "reaction_10466983": { "compartment": "compartment_876", "id": "reaction_10466983", "reactome": "R-DME-2731122", "name": "Syndecans 1, 2 & 4 bind VTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443474", "species_10463847" ], "products": [ "species_10466981" ], "modifiers": [], "additional_components": [ "FBgn0024366", "FBgn0010415", "P49415", "FBgn0010415", "O46099", "FBgn0024366" ] }, "reaction_10467077": { "compartment": "compartment_876", "id": "reaction_10467077", "reactome": "R-DME-2750187", "name": "Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467073", "species_10447182" ], "products": [ "species_10467075" ], "modifiers": [], "additional_components": [ "P49415", "FBgn0010415", "species_179856", "species_114519", "P05130", "FBgn0003091", "species_114519", "P05130", "FBgn0003091", "P49415", "FBgn0010415", "species_179856" ] }, "reaction_10466979": { "compartment": "compartment_876", "id": "reaction_10466979", "reactome": "R-DME-2731078", "name": "Syndecans 2, (4) bind TGFB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437858", "species_10463849" ], "products": [ "species_10466977" ], "modifiers": [], "additional_components": [ "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "FBgn0010415", "P49415", "FBgn0010415", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10443455": { "compartment": "compartment_984", "id": "reaction_10443455", "reactome": "R-DME-216050", "name": "Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443449", "species_10443451" ], "products": [ "species_10443453" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "P11584", "FBgn0004657", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10498486": { "compartment": "compartment_876", "id": "reaction_10498486", "reactome": "R-DME-9679740", "name": "ITGA4:ITGB1 binds natalizumab", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9679737", "species_10441036" ], "products": [ "species_10498484" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10469592": { "compartment": "compartment_984", "id": "reaction_10469592", "reactome": "R-DME-4085133", "name": "LUM (lumican) binds integrin alpha2beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469588", "species_10443928" ], "products": [ "species_10469590" ], "modifiers": [], "additional_components": [ "FBgn0028872", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "M9MSI4", "FBgn0028872" ] }, "reaction_10443635": { "compartment": "compartment_876", "id": "reaction_10443635", "reactome": "R-DME-265422", "name": "Interaction of integrin alphaEbeta7 with Cadherin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442033", "species_10443631" ], "products": [ "species_10443633" ], "modifiers": [], "additional_components": [ "FBgn0262018", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "Q9VJB6", "FBgn0262018" ] }, "reaction_10465779": { "compartment": "compartment_984", "id": "reaction_10465779", "reactome": "R-DME-2426259", "name": "COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465761", "species_10442024" ], "products": [ "species_10465777" ], "modifiers": [], "additional_components": [ "Q9VM97", "FBgn0031850", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q9VM97", "FBgn0031850" ] }, "reaction_10443648": { "compartment": "compartment_984", "id": "reaction_10443648", "reactome": "R-DME-265429", "name": "THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443642", "species_10443644" ], "products": [ "species_10443646" ], "modifiers": [], "additional_components": [ "Q9VM97", "FBgn0031850", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "O44386", "FBgn0286785", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "O44386", "FBgn0286785", "Q9W1M8", "FBgn0034880", "Q9V7A4", "FBgn0034005", "Q24247", "FBgn0004456", "Q9VM97", "FBgn0031850" ] }, "reaction_10465638": { "compartment": "compartment_984", "id": "reaction_10465638", "reactome": "R-DME-2395364", "name": "LTBP4 binds TGF-Beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465600", "species_10465570" ], "products": [ "species_10465636" ], "modifiers": [], "additional_components": [ "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P98163", "FBgn0004649", "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649", "Q9V4B8", "FBgn0051999", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234" ] }, "reaction_10465606": { "compartment": "compartment_876", "id": "reaction_10465606", "reactome": "R-DME-2395320", "name": "Latent TGF-beta-1 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465600", "species_10465602" ], "products": [ "species_10465604" ], "modifiers": [], "additional_components": [ "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234" ] }, "reaction_10465668": { "compartment": "compartment_876", "id": "reaction_10465668", "reactome": "R-DME-2396029", "name": "Latent TGF-beta-3 binds integrins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443447", "species_10465628" ], "products": [ "species_10465666" ], "modifiers": [], "additional_components": [ "P12080", "FBgn0001250", "P11584", "FBgn0004657", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P12080", "FBgn0001250", "P11584", "FBgn0004657" ] }, "reaction_10465634": { "compartment": "compartment_984", "id": "reaction_10465634", "reactome": "R-DME-2395328", "name": "LTBP1, LTBP3 bind TGF-Beta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10465608", "species_10465630" ], "products": [ "species_10465632" ], "modifiers": [], "additional_components": [ "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649" ] }, "reaction_10489074": { "compartment": "compartment_876", "id": "reaction_10489074", "reactome": "R-DME-8855130", "name": "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489064" ], "products": [ "species_10489072" ], "modifiers": [], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "A8JRD0", "FBgn0066101", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "A8JRD0", "FBgn0066101" ] }, "reaction_10493840": { "compartment": "compartment_7660", "id": "reaction_10493840", "reactome": "R-DME-8952128", "name": "RUNX3 binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10467611" ], "products": [ "species_10493838" ], "modifiers": [], "additional_components": [ "FBgn0083981", "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "M9PI08", "FBgn0083981" ] }, "reaction_10491733": { "compartment": "compartment_7660", "id": "reaction_10491733", "reactome": "R-DME-8878117", "name": "RUNX3 binds ZFHX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10491729" ], "products": [ "species_10491731" ], "modifiers": [ [ "species_10437860", "catalyst" ] ], "additional_components": [ "FBgn0083981", "FBgn0004607", "P28167", "FBgn0004607", "M9PI08", "FBgn0083981", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914" ] }, "reaction_10491740": { "compartment": "compartment_7660", "id": "reaction_10491740", "reactome": "R-DME-8878143", "name": "RUNX3 binds SMAD3 and SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10491736" ], "products": [ "species_10491738" ], "modifiers": [], "additional_components": [ "FBgn0083981", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "M9PI08", "FBgn0083981" ] }, "reaction_10436609": { "compartment": "compartment_7660", "id": "reaction_10436609", "reactome": "R-DME-163664", "name": "AMP binds to gamma subunit of AMP kinase heterotrimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164121", "species_10436603" ], "products": [ "species_10436607" ], "modifiers": [], "additional_components": [ "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357", "species_76577", "A1Z7Q8", "FBgn0260972" ] }, "reaction_10489849": { "compartment": "compartment_7660", "id": "reaction_10489849", "reactome": "R-DME-8865613", "name": "BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489819", "species_10489827" ], "products": [ "species_10489847" ], "modifiers": [], "additional_components": [ "FBgn0011785", "FBgn0001199", "P02299", "FBgn0001199", "Q9VC96", "FBgn0011785" ] }, "reaction_10489823": { "compartment": "compartment_7660", "id": "reaction_10489823", "reactome": "R-DME-8865605", "name": "BRWD1 binds SMARCA4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489819", "species_10467677" ], "products": [ "species_10489821" ], "modifiers": [], "additional_components": [ "FBgn0011785", "FBgn0000212", "P25439", "FBgn0000212", "Q9VC96", "FBgn0011785" ] }, "reaction_10454519": { "compartment": "compartment_13231", "id": "reaction_10454519", "reactome": "R-DME-913529", "name": "Translocation of p-STAT1:p-STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454427" ], "products": [ "species_10454513" ], "modifiers": [ [ "species_10454517", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E", "O18388", "FBgn0262743", "Q24151", "Stat92E", "O76521", "FBgn0024889" ] }, "reaction_10454155": { "compartment": "compartment_13231", "id": "reaction_10454155", "reactome": "R-DME-873917", "name": "Translocation of STAT1 dimer to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454149" ], "products": [ "species_10454153" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10496089": { "compartment": "compartment_70101", "id": "reaction_10496089", "reactome": "R-DME-9009950", "name": "PDE12 cleaves 2'-5' oligoadenylates ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8983696" ], "products": [ "species_70106", "species_113592", "species_76577" ], "modifiers": [ [ "species_10496086", "catalyst" ] ], "additional_components": [ "species_113592", "FBgn0051759" ] }, "reaction_10461341": { "compartment": "compartment_70101", "id": "reaction_10461341", "reactome": "R-DME-1678842", "name": "Competitive inhibition of translation initiation by ISGylated 4EHP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461329", "species_10461337" ], "products": [ "species_10461335", "species_10461339" ], "modifiers": [], "additional_components": [ "Q94981", "FBgn0017418", "E8NHA2", "FBgn0035207", "Q9VZ73", "FBgn0035584", "Q7K738", "FBgn0026316", "P52487", "FBgn0017456", "E1JIV5", "FBgn0053100", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A8DZ29", "FBgn0023213", "Q9VCH1", "FBgn0260634", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A8DZ29", "FBgn0023213", "Q9VCH1", "FBgn0260634", "Q94981", "FBgn0017418", "E8NHA2", "FBgn0035207", "Q9VZ73", "FBgn0035584", "Q7K738", "FBgn0026316", "P52487", "FBgn0017456", "E1JIV5", "FBgn0053100" ] }, "reaction_10453068": { "compartment": "compartment_5460", "id": "reaction_10453068", "reactome": "R-DME-507775", "name": "PXLP-K341-GPT2 transaminates L-Ala to form PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_379697" ], "products": [ "species_113557", "species_113552" ], "modifiers": [ [ "species_10453063", "catalyst" ] ], "additional_components": [ "Q9VYD9", "FBgn0030478" ] }, "reaction_10428164": { "compartment": "compartment_70101", "id": "reaction_10428164", "reactome": "R-DME-70524", "name": "PXLP-K314-GPT transaminates PYR to form L-Ala", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_29398" ], "products": [ "species_29406", "species_29432" ], "modifiers": [ [ "species_10428159", "catalyst" ] ], "additional_components": [ "Q9VYD9", "FBgn0030478" ] }, "reaction_10443038": { "compartment": "compartment_70101", "id": "reaction_10443038", "reactome": "R-DME-210444", "name": "L-Glutamate loading of synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_10443035" ], "products": [ "species_10442948" ], "modifiers": [ [ "species_10443035", "catalyst" ] ], "additional_components": [ "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P25228", "FBgn0005586", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P25228", "FBgn0005586" ] }, "reaction_10442860": { "compartment": "compartment_984", "id": "reaction_10442860", "reactome": "R-DME-210404", "name": "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_210382", "species_29804", "species_74113" ], "products": [ "species_74126", "species_29404", "species_70106", "species_83910" ], "modifiers": [ [ "species_10442846", "catalyst" ], [ "species_10442858", "inhibitor" ] ], "additional_components": [ "FBgn0026438", "FBgn0032704" ] }, "reaction_10428262": { "compartment": "compartment_5460", "id": "reaction_10428262", "reactome": "R-DME-70609", "name": "glutamine + H2O => glutamate + NH4+ [GLS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113522", "species_113521" ], "products": [ "species_113561", "species_113552" ], "modifiers": [ [ "species_10428259", "catalyst" ] ], "additional_components": [ "Q1RL13", "FBgn0261625" ] }, "reaction_10443028": { "compartment": "compartment_984", "id": "reaction_10443028", "reactome": "R-DME-210430", "name": "Release of L-Glutamate at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443005", "species_74016" ], "products": [ "species_10443025", "species_210382", "species_10443011", "species_10442919", "species_10443003", "species_10442973", "species_10443021", "species_10443023" ], "modifiers": [ [ "species_10443005", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0031424", "FBgn0004574", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "species_74016", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q24547", "FBgn0013343" ] }, "reaction_10443008": { "compartment": "compartment_70101", "id": "reaction_10443008", "reactome": "R-DME-210426", "name": "Glutamate synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10442948", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10443005" ], "modifiers": [ [ "species_10442948", "catalyst" ], [ "species_10442988", "catalyst" ] ], "additional_components": [ "FBgn0013343", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "Q24547", "FBgn0013343", "Q9VQC0", "FBgn0031424", "P21521", "FBgn0004242", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_210382", "P25228", "FBgn0005586", "FBgn0025726" ] }, "reaction_10480942": { "compartment": "compartment_7660", "id": "reaction_10480942", "reactome": "R-DME-6791235", "name": "GADD45A binds AURKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480938", "species_10480365" ], "products": [ "species_10480940" ], "modifiers": [], "additional_components": [ "FBgn0000147", "FBgn0033153", "A1Z6W5", "FBgn0033153", "Q9VGF9", "FBgn0000147" ] }, "reaction_10485962": { "compartment": "compartment_70101", "id": "reaction_10485962", "reactome": "R-DME-6803875", "name": "SFN dimer binds CDK1 and CCNB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432002", "species_10437611" ], "products": [ "species_10485960" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P23572", "FBgn0004106", "P20439", "FBgn0000405", "P29310", "14-3-3zeta" ] }, "reaction_10485964": { "compartment": "compartment_70101", "id": "reaction_10485964", "reactome": "R-DME-6803890", "name": "SFN dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432000" ], "products": [ "species_10432002" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta" ] }, "reaction_10480369": { "compartment": "compartment_7660", "id": "reaction_10480369", "reactome": "R-DME-6791109", "name": "GADD45A binds PCNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427633", "species_10480365" ], "products": [ "species_10480367" ], "modifiers": [], "additional_components": [ "P17917", "FBgn0005655", "FBgn0033153", "A1Z6W5", "FBgn0033153", "P17917", "FBgn0005655" ] }, "reaction_10432502": { "compartment": "compartment_70101", "id": "reaction_10432502", "reactome": "R-DME-75883", "name": "DHRS7B reduces GO3P to HXDG3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75973", "species_29364" ], "products": [ "species_29366", "species_390422" ], "modifiers": [ [ "species_10432499", "catalyst" ] ], "additional_components": [ "FBgn0027583" ] }, "reaction_10498530": { "compartment": "compartment_70101", "id": "reaction_10498530", "reactome": "R-DME-9681616", "name": "AP2 binds chlorpromazine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9648300", "species_10469475" ], "products": [ "species_10489943" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10489892": { "compartment": "compartment_70101", "id": "reaction_10489892", "reactome": "R-DME-8866275", "name": "UBQLNs bind UIM-containing adaptor proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489882", "species_10489888" ], "products": [ "species_10489890" ], "modifiers": [], "additional_components": [ "Q8IPM2", "FBgn0051528", "Q9VHX2", "FBgn0037538", "Q9VWD9", "FBgn0031057", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q8IPM2", "FBgn0051528", "Q9VHX2", "FBgn0037538", "Q9VWD9", "FBgn0031057" ] }, "reaction_10489638": { "compartment": "compartment_70101", "id": "reaction_10489638", "reactome": "R-DME-8863721", "name": "NEDD8-STON binds TOR1 hexamer and COP9 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489614", "species_10489598", "species_10489634" ], "products": [ "species_10489636" ], "modifiers": [], "additional_components": [ "O77277", "FBgn0025615", "FBgn0016975", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "O77277", "FBgn0025615", "Q24212", "FBgn0016975" ] }, "reaction_10489576": { "compartment": "compartment_876", "id": "reaction_10489576", "reactome": "R-DME-8863472", "name": "DAB2 binds LRP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489560", "species_10489572" ], "products": [ "species_10489574" ], "modifiers": [], "additional_components": [ "FBgn0000414", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414" ] }, "reaction_10489641": { "compartment": "compartment_70101", "id": "reaction_10489641", "reactome": "R-DME-8863723", "name": "COP9 and TOR1 deneddylate STON2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489636" ], "products": [ "species_10489614", "species_10477764", "species_10489634", "species_10489552" ], "modifiers": [ [ "species_10489636", "catalyst" ] ], "additional_components": [ "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "O77277", "FBgn0025615", "Q24212", "FBgn0016975", "O77277", "FBgn0025615", "FBgn0032725", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "FBgn0016975", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836", "O77277", "FBgn0025615", "Q24212", "FBgn0016975" ] }, "reaction_10489963": { "compartment": "compartment_876", "id": "reaction_10489963", "reactome": "R-DME-8866279", "name": "Epsin family proteins bind ubiquitinated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489959", "species_10489888" ], "products": [ "species_10489961" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9W111", "FBgn0035060", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VS85", "FBgn0028582", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341" ] }, "reaction_10489643": { "compartment": "compartment_70101", "id": "reaction_10489643", "reactome": "R-DME-8863727", "name": "STON2 is neddylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477764", "species_10489552" ], "products": [ "species_10489598" ], "modifiers": [], "additional_components": [ "FBgn0032725", "FBgn0016975", "FBgn0016975" ] }, "reaction_10489969": { "compartment": "compartment_876", "id": "reaction_10489969", "reactome": "R-DME-8866283", "name": "ARBB recruits GPCRs into clathrin-coated pits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489853", "species_10489365" ], "products": [ "species_10489965" ], "modifiers": [ [ "species_10489967", "inhibitor" ] ], "additional_components": [ "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q8IPM2", "FBgn0051528", "Q9VHX2", "FBgn0037538", "Q9VWD9", "FBgn0031057", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582" ] }, "reaction_10490099": { "compartment": "compartment_876", "id": "reaction_10490099", "reactome": "R-DME-8867613", "name": "PICALM binds R-SNAREs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490093", "species_10490091" ], "products": [ "species_10490097" ], "modifiers": [], "additional_components": [ "FBgn0086372", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372" ] }, "reaction_10489558": { "compartment": "compartment_876", "id": "reaction_10489558", "reactome": "R-DME-8863463", "name": "STON2 binds SYT proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489547", "species_10489552" ], "products": [ "species_10489556" ], "modifiers": [], "additional_components": [ "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "FBgn0016975", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090" ] }, "reaction_10489945": { "compartment": "compartment_876", "id": "reaction_10489945", "reactome": "R-DME-8866277", "name": "AP-2 directly binds some endocytic cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469475", "species_10489939" ], "products": [ "species_10489941" ], "modifiers": [ [ "species_10489943", "inhibitor" ] ], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10489595": { "compartment": "compartment_876", "id": "reaction_10489595", "reactome": "R-DME-8863718", "name": "AGFG1 binds VAMP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489591", "species_10489589" ], "products": [ "species_10489593" ], "modifiers": [], "additional_components": [ "FBgn0266186", "FBgn0020304", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186" ] }, "reaction_10489855": { "compartment": "compartment_876", "id": "reaction_10489855", "reactome": "R-DME-8866269", "name": "ARRB bind GPCRs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489851", "species_10474367" ], "products": [ "species_10489853" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10484330": { "compartment": "compartment_7660", "id": "reaction_10484330", "reactome": "R-DME-6799246", "name": "CHEK1 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427808", "species_29358" ], "products": [ "species_113582", "species_10427813" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0261278" ] }, "reaction_10438565": { "compartment": "compartment_7660", "id": "reaction_10438565", "reactome": "R-DME-176116", "name": "Recruitment and activation of Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438550" ], "products": [ "species_113582", "species_10427785" ], "modifiers": [ [ "species_10438562", "catalyst" ] ], "additional_components": [ "FBgn0261278", "FBgn0261278", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367" ] }, "reaction_10432380": { "compartment": "compartment_7660", "id": "reaction_10432380", "reactome": "R-DME-75809", "name": "Phosphorylation of Cdc25C at Ser216 by CHEK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10431972" ], "products": [ "species_113582", "species_10431980" ], "modifiers": [ [ "species_10427797", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0019686" ] }, "reaction_10497068": { "compartment": "compartment_70101", "id": "reaction_10497068", "reactome": "R-DME-9029987", "name": "p-S216-CDC25C translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431980" ], "products": [ "species_10431988" ], "modifiers": [], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10498000": { "compartment": "compartment_17938", "id": "reaction_10498000", "reactome": "R-DME-9640167", "name": "RRAGA,B exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10497993" ], "products": [ "species_10497997", "species_29420" ], "modifiers": [ [ "species_10497993", "catalyst" ] ], "additional_components": [ "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "species_29468", "species_29468", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "species_29468" ] }, "reaction_10498113": { "compartment": "compartment_17938", "id": "reaction_10498113", "reactome": "R-DME-9645598", "name": "RRAGC,D hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497982" ], "products": [ "species_29372", "species_10497986" ], "modifiers": [ [ "species_10497982", "catalyst" ], [ "species_10498111", "catalyst" ] ], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438", "Q9VS33", "FBgn0261111", "E3CTN7", "FBgn0036684" ] }, "reaction_10498116": { "compartment": "compartment_17938", "id": "reaction_10498116", "reactome": "R-DME-9645608", "name": "v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497995", "species_10436975" ], "products": [ "species_10498002" ], "modifiers": [], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272" ] }, "reaction_10497989": { "compartment": "compartment_17938", "id": "reaction_10497989", "reactome": "R-DME-9639286", "name": "RRAGC,D exchanges GTP for GDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497982", "species_29420" ], "products": [ "species_29438", "species_10497986" ], "modifiers": [ [ "species_10497982", "catalyst" ] ], "additional_components": [ "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "species_29438" ] }, "reaction_10498009": { "compartment": "compartment_17938", "id": "reaction_10498009", "reactome": "R-DME-9640195", "name": "RRAGA,B hydrolyzes GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498004" ], "products": [ "species_29372", "species_10498006" ], "modifiers": [ [ "species_10498004", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VND8", "Rheb", "species_29438", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10498124": { "compartment": "compartment_17938", "id": "reaction_10498124", "reactome": "R-DME-9646468", "name": "mTORC1 binds RHEB:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436956", "species_10498002" ], "products": [ "species_10498004" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29438", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "P23380", "FBgn0262736", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VP18", "FBgn0028663", "Q9VZG7", "FBgn0028664", "A1ZBF7", "FBgn0028669", "Q9VE75", "FBgn0028670", "Q9VE77", "FBgn0038613", "Q9VKF6", "FBgn0032373", "Q9XZ10", "FBgn0028671", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10437161": { "compartment": "compartment_70616", "id": "reaction_10437161", "reactome": "R-DME-166387", "name": "The FA anion diffuses away laterally from UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437154" ], "products": [ "species_166216", "species_10437150" ], "modifiers": [], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872" ] }, "reaction_10437159": { "compartment": "compartment_70616", "id": "reaction_10437159", "reactome": "R-DME-166220", "name": "FA anion diffuses laterally to UCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_166213", "species_10437150" ], "products": [ "species_10437152" ], "modifiers": [], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213" ] }, "reaction_10437157": { "compartment": "compartment_70616", "id": "reaction_10437157", "reactome": "R-DME-166214", "name": "FA anion flip-flops to the opposite surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437152" ], "products": [ "species_10437154" ], "modifiers": [ [ "species_10437152", "catalyst" ] ], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213", "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_166213" ] }, "reaction_10437560": { "compartment": "compartment_70616", "id": "reaction_10437560", "reactome": "R-DME-170026", "name": "Protons are translocated from the intermembrane space to the matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_163953" ], "products": [ "species_113529" ], "modifiers": [ [ "species_10437150", "catalyst" ], [ "species_30495", "catalyst" ], [ "species_170037", "inhibitor" ] ], "additional_components": [ "Q7K566", "FBgn0036199", "Q9VX14", "FBgn0030872", "species_113592", "species_29370", "species_29420", "species_29438" ] }, "reaction_10442079": { "compartment": "compartment_70101", "id": "reaction_10442079", "reactome": "R-DME-202960", "name": "Caspase mediated cleavage of C-IAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442065" ], "products": [ "species_10442071", "species_10442077" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "Q9XYF4", "FBgn0026404" ] }, "reaction_10497056": { "compartment": "compartment_7660", "id": "reaction_10497056", "reactome": "R-DME-9029680", "name": "Caspase-7 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434869" ], "products": [ "species_10444173" ], "modifiers": [], "additional_components": [ "Q9VET9", "FBgn0028381", "Q9VET9", "FBgn0028381" ] }, "reaction_10441599": { "compartment": "compartment_70101", "id": "reaction_10441599", "reactome": "R-DME-201608", "name": "Caspase-mediated cleavage of alpha adducin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441593" ], "products": [ "species_10441595", "species_10441597" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0263391", "FBgn0263391", "FBgn0263391", "Q9XYF4", "FBgn0026404" ] }, "reaction_10442090": { "compartment": "compartment_70101", "id": "reaction_10442090", "reactome": "R-DME-202966", "name": "Caspase mediated cleavage of HIP-55", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442084" ], "products": [ "species_10442086", "species_10442088" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0036372", "FBgn0036372", "FBgn0036372", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441658": { "compartment": "compartment_70101", "id": "reaction_10441658", "reactome": "R-DME-201637", "name": "Caspase-mediated cleavage of plectin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441643" ], "products": [ "species_10441645", "species_10441647" ], "modifiers": [ [ "species_10441655", "catalyst" ] ], "additional_components": [ "FBgn0013733", "FBgn0013733", "FBgn0013733", "O01382", "FBgn0019972" ] }, "reaction_10442101": { "compartment": "compartment_70101", "id": "reaction_10442101", "reactome": "R-DME-202967", "name": "Caspase mediated cleavage of alpha-II-Fodrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442095" ], "products": [ "species_10442097", "species_10442099" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0250789", "FBgn0250789", "FBgn0250789", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441621": { "compartment": "compartment_70101", "id": "reaction_10441621", "reactome": "R-DME-201629", "name": "Caspase-mediated cleavage of Tau", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441615" ], "products": [ "species_10441617", "species_10441619" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0266579", "FBgn0266579", "FBgn0266579", "Q9XYF4", "FBgn0026404" ] }, "reaction_10443560": { "compartment": "compartment_7660", "id": "reaction_10443560", "reactome": "R-DME-264865", "name": "Caspase-mediated cleavage of Lamin A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443537" ], "products": [ "species_10443543", "species_10443549" ], "modifiers": [ [ "species_10443557", "catalyst" ] ], "additional_components": [ "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q03427", "FBgn0010397", "P08928", "FBgn0002525", "Q9VET9", "FBgn0028381" ] }, "reaction_10497066": { "compartment": "compartment_13231", "id": "reaction_10497066", "reactome": "R-DME-9029690", "name": "Caspase-6 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497064" ], "products": [ "species_10443557" ], "modifiers": [], "additional_components": [ "Q9VET9", "FBgn0028381", "Q9VET9", "FBgn0028381" ] }, "reaction_10443568": { "compartment": "compartment_7660", "id": "reaction_10443568", "reactome": "R-DME-264871", "name": "Caspase-mediated cleavage of Lamin B1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443562" ], "products": [ "species_10443564", "species_10443566" ], "modifiers": [ [ "species_10443557", "catalyst" ] ], "additional_components": [ "FBgn0002525", "FBgn0002525", "FBgn0002525", "Q9VET9", "FBgn0028381" ] }, "reaction_10444150": { "compartment": "compartment_12045", "id": "reaction_10444150", "reactome": "R-DME-351894", "name": "Caspase mediated cleavage of BAP31", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444141" ], "products": [ "species_10444145", "species_10444147", "species_10444143" ], "modifiers": [ [ "species_10444126", "catalyst" ] ], "additional_components": [ "FBgn0035165", "FBgn0035165", "FBgn0035165", "FBgn0035165", "O01382", "FBgn0019972" ] }, "reaction_10444118": { "compartment": "compartment_70101", "id": "reaction_10444118", "reactome": "R-DME-351849", "name": "Caspase-mediated cleavage of Etk", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444112" ], "products": [ "species_10444114", "species_10444116" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0003502", "FBgn0003502", "FBgn0003502", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441588": { "compartment": "compartment_70101", "id": "reaction_10441588", "reactome": "R-DME-201603", "name": "Caspase-mediated cleavage of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441582" ], "products": [ "species_10441584", "species_10441586" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0259680", "FBgn0259680", "FBgn0259680", "Q9XYF4", "FBgn0026404" ] }, "reaction_10443314": { "compartment": "compartment_70101", "id": "reaction_10443314", "reactome": "R-DME-212552", "name": "Caspase 3-mediated cleavage of PKC delta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434441" ], "products": [ "species_10443312", "species_10443310" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0259680", "FBgn0259680", "FBgn0259680", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444176": { "compartment": "compartment_7660", "id": "reaction_10444176", "reactome": "R-DME-351936", "name": "Caspase-mediated cleavage of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438600" ], "products": [ "species_10444163", "species_10444165" ], "modifiers": [ [ "species_10444173", "catalyst" ] ], "additional_components": [ "FBgn0052251", "FBgn0052251", "FBgn0052251", "Q9VET9", "FBgn0028381" ] }, "reaction_10444238": { "compartment": "compartment_7660", "id": "reaction_10444238", "reactome": "R-DME-352268", "name": "Cleavage of Satb1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444232" ], "products": [ "species_10444234", "species_10444236" ], "modifiers": [ [ "species_10443557", "catalyst" ] ], "additional_components": [ "FBgn0020307", "FBgn0020307", "FBgn0020307", "Q9VET9", "FBgn0028381" ] }, "reaction_10442059": { "compartment": "compartment_70101", "id": "reaction_10442059", "reactome": "R-DME-202947", "name": "Caspase mediated cleavage of APC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442045" ], "products": [ "species_10442051", "species_10442057" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9VAS9", "FBgn0015589", "Q9Y1T2", "Apc2", "Q9Y1T2", "Apc2", "Q9VAS9", "FBgn0015589", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441610": { "compartment": "compartment_70101", "id": "reaction_10441610", "reactome": "R-DME-201611", "name": "Caspase-mediated cleavage of Rock-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441604" ], "products": [ "species_10441606", "species_10441608" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0026181", "FBgn0026181", "FBgn0026181", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441669": { "compartment": "compartment_70101", "id": "reaction_10441669", "reactome": "R-DME-201640", "name": "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441663" ], "products": [ "species_10441665", "species_10441667" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0031633", "FBgn0031633", "FBgn0031633", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444035": { "compartment": "compartment_70101", "id": "reaction_10444035", "reactome": "R-DME-350651", "name": "Caspase-mediated cleavage of MASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444029" ], "products": [ "species_10444033", "species_10444031" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0266465", "FBgn0266465", "FBgn0266465", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444161": { "compartment": "compartment_70101", "id": "reaction_10444161", "reactome": "R-DME-351901", "name": "Caspase-mediated cleavage of MST3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444152" ], "products": [ "species_10444154", "species_10444156" ], "modifiers": [ [ "species_10444158", "catalyst" ] ], "additional_components": [ "FBgn0266465", "FBgn0266465", "FBgn0266465", "Q9XYF4", "FBgn0026404", "Q9VET9", "FBgn0028381" ] }, "reaction_10442109": { "compartment": "compartment_70101", "id": "reaction_10442109", "reactome": "R-DME-202969", "name": "Caspase mediated cleavage of beta-catenin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442103" ], "products": [ "species_10442105", "species_10442107" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "Q9XYF4", "FBgn0026404" ] }, "reaction_10441580": { "compartment": "compartment_876", "id": "reaction_10441580", "reactome": "R-DME-201595", "name": "Caspase-mediated cleavage of plakophilin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441575" ], "products": [ "species_10441577" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0260799", "FBgn0260799", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441641": { "compartment": "compartment_70101", "id": "reaction_10441641", "reactome": "R-DME-201636", "name": "Caspase-mediated cleavage of Desmoplakin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441637" ], "products": [ "species_10441639" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0013733", "FBgn0013733", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444136": { "compartment": "compartment_70101", "id": "reaction_10444136", "reactome": "R-DME-351876", "name": "Caspase-mediated cleavage of occludin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444130" ], "products": [ "species_10444132", "species_10444134" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0014037", "FBgn0014037", "FBgn0014037", "Q9XYF4", "FBgn0026404" ] }, "reaction_10442039": { "compartment": "compartment_876", "id": "reaction_10442039", "reactome": "R-DME-202939", "name": "Caspase-mediated cleavage of E-Cadherin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442033" ], "products": [ "species_10442035", "species_10442037" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0262018", "FBgn0262018", "FBgn0262018", "Q9XYF4", "FBgn0026404" ] }, "reaction_10441632": { "compartment": "compartment_70101", "id": "reaction_10441632", "reactome": "R-DME-201630", "name": "Caspase-mediated cleavage of Acinus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441626" ], "products": [ "species_10441628", "species_10441630" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0263198", "FBgn0263198", "FBgn0263198", "Q9XYF4", "FBgn0026404" ] }, "reaction_10444189": { "compartment": "compartment_70101", "id": "reaction_10444189", "reactome": "R-DME-351948", "name": "Mitochondrial recruitment of Drp1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444185" ], "products": [ "species_10444187" ], "modifiers": [ [ "species_10444143", "catalyst" ] ], "additional_components": [ "FBgn0026479", "FBgn0026479", "FBgn0035165" ] }, "reaction_10444180": { "compartment": "compartment_13231", "id": "reaction_10444180", "reactome": "R-DME-351947", "name": "Nuclear translocation of catalytic domain of Mst3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444154" ], "products": [ "species_10444178" ], "modifiers": [], "additional_components": [ "FBgn0266465", "FBgn0266465" ] }, "reaction_10443148": { "compartment": "compartment_13231", "id": "reaction_10443148", "reactome": "R-DME-211206", "name": "Translocation of DFF to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443134" ], "products": [ "species_10443146" ], "modifiers": [], "additional_components": [ "O18388", "FBgn0262743", "O76521", "FBgn0024889", "Q9V3H0", "FBgn0028406", "O18388", "FBgn0262743", "O76521", "FBgn0024889", "Q9V3H0", "FBgn0028406" ] }, "reaction_10443158": { "compartment": "compartment_13231", "id": "reaction_10443158", "reactome": "R-DME-211219", "name": "Translocation of caspase-3 to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434841" ], "products": [ "species_10443156" ], "modifiers": [], "additional_components": [ "Q9XYF4", "FBgn0026404", "Q9XYF4", "FBgn0026404" ] }, "reaction_10443126": { "compartment": "compartment_7660", "id": "reaction_10443126", "reactome": "R-DME-211193", "name": "Homodimerization of DFF40", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443122" ], "products": [ "species_10443124" ], "modifiers": [], "additional_components": [ "FBgn0028406", "Q9V3H0", "FBgn0028406" ] }, "reaction_10443924": { "compartment": "compartment_7660", "id": "reaction_10443924", "reactome": "R-DME-266204", "name": "Association of HMGB1/HMGB2 with chromatin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443920", "species_29428" ], "products": [ "species_10443922" ], "modifiers": [], "additional_components": [ "Q24537", "Dsp1", "E1JIT5", "FBgn0038979", "Q9VCZ5", "FBgn0038978", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "E1JIT5", "FBgn0038979", "Q9VCZ5", "FBgn0038978", "Q05783", "FBgn0004362" ] }, "reaction_10444128": { "compartment": "compartment_70101", "id": "reaction_10444128", "reactome": "R-DME-351863", "name": "Translocation of active caspase-8 to the mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441655" ], "products": [ "species_10444126" ], "modifiers": [], "additional_components": [ "O01382", "FBgn0019972", "O01382", "FBgn0019972" ] }, "reaction_10444436": { "compartment": "compartment_70101", "id": "reaction_10444436", "reactome": "R-DME-373705", "name": "Caspase cleavage of DCC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444421" ], "products": [ "species_10444433", "species_10444427" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "O97394", "FBgn0021764", "A1Z920", "FBgn0011592", "Q9XYF4", "FBgn0026404" ] }, "reaction_10497776": { "compartment": "compartment_70101", "id": "reaction_10497776", "reactome": "R-DME-9627369", "name": "SEPT4 binds XIAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497772", "species_10434883" ], "products": [ "species_10497774" ], "modifiers": [], "additional_components": [ "Q0KHR7", "FBgn0259923", "Q24306", "Diap1", "Q24307", "Diap2", "Q0KHR7", "FBgn0259923", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10497768": { "compartment": "compartment_70101", "id": "reaction_10497768", "reactome": "R-DME-9627104", "name": "XIAP binds CASP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434883", "species_10434841" ], "products": [ "species_10497766" ], "modifiers": [], "additional_components": [ "Q24306", "Diap1", "Q24307", "Diap2", "Q9XYF4", "FBgn0026404", "Q9XYF4", "FBgn0026404", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10497770": { "compartment": "compartment_70101", "id": "reaction_10497770", "reactome": "R-DME-9627107", "name": "XIAP binds CASP7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434883", "species_10434869" ], "products": [ "species_10434885" ], "modifiers": [], "additional_components": [ "Q24306", "Diap1", "Q24307", "Diap2", "Q9VET9", "FBgn0028381", "Q9VET9", "FBgn0028381", "Q24306", "Diap1", "Q24307", "Diap2" ] }, "reaction_10486228": { "compartment": "compartment_70101", "id": "reaction_10486228", "reactome": "R-DME-6805811", "name": "Release of SEPT4 from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486224" ], "products": [ "species_10486226" ], "modifiers": [], "additional_components": [ "FBgn0259923", "FBgn0259923" ] }, "reaction_10434873": { "compartment": "compartment_17906", "id": "reaction_10434873", "reactome": "R-DME-114284", "name": "Release of Cytochrome c from mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434871" ], "products": [ "species_10434846" ], "modifiers": [], "additional_components": [ "FBgn0284248", "FBgn0284248" ] }, "reaction_10433151": { "compartment": "compartment_5460", "id": "reaction_10433151", "reactome": "R-DME-77256", "name": "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77255", "species_113521" ], "products": [ "species_77252" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433190": { "compartment": "compartment_5460", "id": "reaction_10433190", "reactome": "R-DME-77309", "name": "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77253" ], "products": [ "species_77308", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10468301": { "compartment": "compartment_7660", "id": "reaction_10468301", "reactome": "R-DME-3318415", "name": "ATF2 acetylates histone H2B, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467826", "species_113560" ], "products": [ "species_2485002", "species_10468296" ], "modifiers": [ [ "species_10437332", "catalyst" ] ], "additional_components": [ "FBgn0001198", "FBgn0001198", "FBgn0265193" ] }, "reaction_10468772": { "compartment": "compartment_7660", "id": "reaction_10468772", "reactome": "R-DME-3662335", "name": "EP300 acetylates histone H2A, H2B, H3, H4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468720", "species_113560" ], "products": [ "species_2485002", "species_10468769" ], "modifiers": [ [ "species_10458126", "catalyst" ] ], "additional_components": [ "FBgn0261617" ] }, "reaction_10472691": { "compartment": "compartment_7660", "id": "reaction_10472691", "reactome": "R-DME-5579018", "name": "NCOA1(868-1441) binds PAX3(1-319)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472670", "species_10472687" ], "products": [ "species_10472689" ], "modifiers": [], "additional_components": [ "FBgn0041092", "P09083", "FBgn0001147", "P09082", "FBgn0001148", "P06601", "FBgn0003145", "P09083", "FBgn0001147", "P09082", "FBgn0001148", "P06601", "FBgn0003145", "M9ND53", "FBgn0041092" ] }, "reaction_10441327": { "compartment": "compartment_70101", "id": "reaction_10441327", "reactome": "R-DME-200423", "name": "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441315", "species_113592" ], "products": [ "species_29370", "species_10441322" ], "modifiers": [ [ "species_10441324", "catalyst" ] ], "additional_components": [ "A1Z784", "FBgn0033246", "species_266099", "A1Z784", "FBgn0033246", "species_266099", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VDD2", "FBgn0264357" ] }, "reaction_10436920": { "compartment": "compartment_876", "id": "reaction_10436920", "reactome": "R-DME-165026", "name": "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164988", "species_74113" ], "products": [ "species_30235", "species_83910" ], "modifiers": [ [ "species_10436917", "catalyst" ] ], "additional_components": [ "Q9VCA0", "FBgn0039178", "Q9VNW8", "FBgn0037144", "Q961R9", "FBgn0038407", "Q9VEY1", "FBgn0038404", "A2RVG5", "FBgn0063649", "Q9VD40", "FBgn0038938", "Q9VNX2", "FBgn0037140" ] }, "reaction_10441335": { "compartment": "compartment_17927", "id": "reaction_10441335", "reactome": "R-DME-200424", "name": "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_201023", "species_201034" ], "products": [ "species_549207", "species_201050" ], "modifiers": [ [ "species_10441332", "catalyst" ] ], "additional_components": [ "FBgn0019830" ] }, "reaction_10441286": { "compartment": "compartment_70616", "id": "reaction_10441286", "reactome": "R-DME-200410", "name": "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_201050" ], "products": [ "species_201023", "species_77281" ], "modifiers": [ [ "species_10441283", "catalyst" ] ], "additional_components": [ "FBgn0035383" ] }, "reaction_10490057": { "compartment": "compartment_70101", "id": "reaction_10490057", "reactome": "R-DME-8866941", "name": "MID1IP1 binds THRSP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432448", "species_10432446" ], "products": [ "species_10432450" ], "modifiers": [], "additional_components": [ "FBgn0035087", "FBgn0035087", "Q9W0X5", "FBgn0035087" ] }, "reaction_10432452": { "compartment": "compartment_70101", "id": "reaction_10432452", "reactome": "R-DME-75851", "name": "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10432440", "catalyst" ], [ "species_10432450", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "species_266099", "A1Z784", "FBgn0033246", "Q9W0X5", "FBgn0035087" ] }, "reaction_10491438": { "compartment": "compartment_70101", "id": "reaction_10491438", "reactome": "R-DME-8876889", "name": "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627", "species_113592", "species_76183" ], "products": [ "species_29372", "species_29370", "species_29508" ], "modifiers": [ [ "species_10441315", "catalyst" ], [ "species_10432450", "catalyst" ], [ "species_76190", "catalyst" ] ], "additional_components": [ "A1Z784", "FBgn0033246", "species_266099", "Q9W0X5", "FBgn0035087" ] }, "reaction_10465132": { "compartment": "compartment_70101", "id": "reaction_10465132", "reactome": "R-DME-2162078", "name": "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161185", "species_29360" ], "products": [ "species_70106", "species_2162081", "species_73473" ], "modifiers": [ [ "species_10429065", "catalyst" ] ], "additional_components": [ "species_1562550", "P46415", "FBgn0011768" ] }, "reaction_10465049": { "compartment": "compartment_70101", "id": "reaction_10465049", "reactome": "R-DME-2161195", "name": "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2161194" ], "products": [ "species_2161176", "species_2161175" ], "modifiers": [ [ "species_10465044", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VHH7", "FBgn0037661" ] }, "reaction_10465129": { "compartment": "compartment_70101", "id": "reaction_10465129", "reactome": "R-DME-2162066", "name": "carbovir + IMP => carbovir monophosphate + inosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161514", "species_29602" ], "products": [ "species_2161176", "species_83927" ], "modifiers": [ [ "species_10431536", "catalyst" ] ], "additional_components": [ "Q9VWV5", "FBgn0052549", "species_29926" ] }, "reaction_10469582": { "compartment": "compartment_70101", "id": "reaction_10469582", "reactome": "R-DME-4084989", "name": "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_4085390" ], "products": [ "species_428633", "species_29372" ], "modifiers": [ [ "species_10469579", "catalyst" ] ], "additional_components": [ "species_29926", "Q9W481", "FBgn0029801" ] }, "reaction_10469572": { "compartment": "compartment_70101", "id": "reaction_10469572", "reactome": "R-DME-4084976", "name": "NANS converts ManNAc-6-P to Neu5Ac-9-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_4085225", "species_29492" ], "products": [ "species_29372", "species_4085390" ], "modifiers": [ [ "species_10469569", "catalyst" ] ], "additional_components": [ "FBgn0038045" ] }, "reaction_10469586": { "compartment": "compartment_20699", "id": "reaction_10469586", "reactome": "R-DME-4085033", "name": "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_727815", "species_4086285" ], "products": [ "species_727810", "species_4086294" ], "modifiers": [ [ "species_10455823", "catalyst" ] ], "additional_components": [ "FBgn0035050" ] }, "reaction_10475581": { "compartment": "compartment_70101", "id": "reaction_10475581", "reactome": "R-DME-5668545", "name": "NIK autophosphorylates on T559", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10446829" ], "products": [ "species_29370", "species_10475579" ], "modifiers": [ [ "species_10446829", "catalyst" ] ], "additional_components": [ "FBgn0024329", "FBgn0024329", "FBgn0024329" ] }, "reaction_10433321": { "compartment": "compartment_7660", "id": "reaction_10433321", "reactome": "R-DME-83805", "name": "Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433315", "species_10432757" ], "products": [ "species_10433319" ], "modifiers": [], "additional_components": [ "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463", "Q6IGE3", "FBgn0262954", "A8JUY3", "FBgn0030687", "Q9VP85", "FBgn0028402", "Q8SYM9", "FBgn0036775", "Q9VNZ3", "FBgn0037121", "A1ZBX4", "FBgn0061362", "Q9VX99", "FBgn0030801", "Q9VTL6", "FBgn0036188", "Q9VC49", "FBgn0039218", "Q86BI8", "FBgn0053051", "Q9VD25", "FBgn0038951", "Q9VG60", "FBgn0038057", "Q24320", "FBgn0003275", "Q9VMX3", "FBgn0031657", "Q7JZF5", "FBgn0033571", "P25167", "FBgn0004463", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512" ] }, "reaction_10433317": { "compartment": "compartment_7660", "id": "reaction_10433317", "reactome": "R-DME-83790", "name": "Binding of TFIIIB to TFIIC: Type 2 Promoter Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432662", "species_10433311" ], "products": [ "species_10433315" ], "modifiers": [], "additional_components": [ "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q9VEL2", "FBgn0038499", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VJZ3", "FBgn0032512" ] }, "reaction_10433313": { "compartment": "compartment_7660", "id": "reaction_10433313", "reactome": "R-DME-83788", "name": "Binding of TFIIIC to Type 2 promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432691", "species_83747" ], "products": [ "species_10433311" ], "modifiers": [], "additional_components": [ "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390", "Q7JVW5", "FBgn0034186", "Q9VJY7", "FBgn0032517", "Q9VU16", "FBgn0260965", "Q9VIZ2", "FBgn0086445", "E1JH07", "FBgn0260390" ] }, "reaction_10443033": { "compartment": "compartment_984", "id": "reaction_10443033", "reactome": "R-DME-210439", "name": "glutamate uptake by astrocytes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382" ], "products": [ "species_29404" ], "modifiers": [ [ "species_10443030", "catalyst" ] ], "additional_components": [] }, "reaction_10428246": { "compartment": "compartment_70101", "id": "reaction_10428246", "reactome": "R-DME-70606", "name": "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_113592", "species_31633" ], "products": [ "species_29372", "species_29370", "species_29472" ], "modifiers": [ [ "species_10428243", "catalyst" ] ], "additional_components": [ "P20478", "FBgn0001145", "P20477", "FBgn0001142" ] }, "reaction_10464591": { "compartment": "compartment_12045", "id": "reaction_10464591", "reactome": "R-DME-2046093", "name": "Translocation of tetracosapentaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046050", "species_211579" ], "products": [ "species_5228339", "species_2046055", "species_211606" ], "modifiers": [ [ "species_10446277", "catalyst" ] ], "additional_components": [ "FBgn0039890" ] }, "reaction_10464593": { "compartment": "compartment_17957", "id": "reaction_10464593", "reactome": "R-DME-2046094", "name": "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046042", "species_113601" ], "products": [ "species_113519", "species_113564", "species_162743", "species_159751", "species_2046045" ], "modifiers": [ [ "species_10453288", "catalyst" ] ], "additional_components": [ "Q9VV87", "FBgn0260960", "Q9VHX7", "FBgn0037534", "Q6NN18", "FBgn0034382", "Q9VCY6", "FBgn0038986", "Q9VH59", "FBgn0037761", "Q4V3H4", "FBgn0037764", "Q9VCY5", "FBgn0053110", "Q9VH58", "FBgn0037762", "A1ZBD2", "FBgn0034383", "Q9VCT3", "FBgn0039030", "Q9VH57", "FBgn0037763", "Q95T98", "FBgn0051523", "Q9VH55", "FBgn0037765", "Q8SXD1", "FBgn0050008", "Q9VCZ0", "FBgn0038983", "Q8IMY2", "FBgn0051141", "Q9VCY7", "FBgn0260942" ] }, "reaction_214880": { "compartment": "compartment_70101", "id": "reaction_214880", "reactome": "R-DME-214880", "name": "DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "In dorsoventral patterning in the embryo, Dorsal (DL) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.", "reactants": [ "species_214746", "species_214759" ], "products": [ "species_214758" ], "modifiers": [], "additional_components": [ "P15330", "dl", "Q03017", "phospho-cact", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P15330", "dl", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214857": { "compartment": "compartment_70101", "id": "reaction_214857", "reactome": "R-DME-214857", "name": "DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "The Dorsal (DL) and Dorsal-related immunity factor (DIF) homodimers in complex with the NF-kappaB inhibitor orthologue, Cactus (CACT), bind to the adaptor proteins Tube (TUB) and phosphorylated Pelle (PLL) in the receptor 'signalling complex' at the plasma membrane.", "reactants": [ "species_206862", "species_206693" ], "products": [ "species_214744" ], "modifiers": [], "additional_components": [ "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL" ] }, "reaction_10467071": { "compartment": "compartment_70101", "id": "reaction_10467071", "reactome": "R-DME-2744361", "name": "BESTs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10467068", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9VUM6", "FBgn0036491", "Q9VRW4", "FBgn0035696", "Q9VUM7", "FBgn0036492" ] }, "reaction_10498689": { "compartment": "compartment_70101", "id": "reaction_10498689", "reactome": "R-DME-9701141", "name": "TRPV1 transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10468206", "catalyst" ] ], "additional_components": [ "FBgn0086693" ] }, "reaction_10468221": { "compartment": "compartment_70101", "id": "reaction_10468221", "reactome": "R-DME-3295579", "name": "TRPs transport extracellular Ca2+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10468218", "catalyst" ] ], "additional_components": [ "Q9VJJ7", "FBgn0032593", "Q9W3W0", "FBgn0086693", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "Q9VW35", "FBgn0261361", "Q7Z020", "FBgn0035934", "A8DYE2", "FBgn0265194" ] }, "reaction_10498686": { "compartment": "compartment_70101", "id": "reaction_10498686", "reactome": "R-DME-9701055", "name": "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10498683", "catalyst" ] ], "additional_components": [ "Q7Z020", "FBgn0035934" ] }, "reaction_10498213": { "compartment": "compartment_876", "id": "reaction_10498213", "reactome": "R-DME-9650165", "name": "ASIC trimers bind H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_10498211" ], "products": [ "species_10466252" ], "modifiers": [], "additional_components": [ "Q9VJI4", "FBgn0032602", "Q9VJI4", "FBgn0032602", "species_163953" ] }, "reaction_10466969": { "compartment": "compartment_70101", "id": "reaction_10466969", "reactome": "R-DME-2730959", "name": "CLCN7:OSTM1 exchanges Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2730999", "species_70106" ], "products": [ "species_428040", "species_352022" ], "modifiers": [ [ "species_10466966", "catalyst" ] ], "additional_components": [ "Q7JZ25", "FBgn0033755", "Q95SH7", "FBgn0035440" ] }, "reaction_10466773": { "compartment": "compartment_70101", "id": "reaction_10466773", "reactome": "R-DME-2684901", "name": "ANOs transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10466770", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "M9PI24", "FBgn0036235", "O97132", "FBgn0000152", "Q9V416", "FBgn0028879" ] }, "reaction_10466997": { "compartment": "compartment_70101", "id": "reaction_10466997", "reactome": "R-DME-2744228", "name": "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10466992", "catalyst" ] ], "additional_components": [ "FBgn0051116" ] }, "reaction_10466803": { "compartment": "compartment_70101", "id": "reaction_10466803", "reactome": "R-DME-2730692", "name": "CLCN4/5/6 exchange Cl- for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2731008" ], "products": [ "species_74722", "species_352022" ], "modifiers": [ [ "species_10466798", "catalyst" ] ], "additional_components": [ "FBgn0036566" ] }, "reaction_10467123": { "compartment": "compartment_17927", "id": "reaction_10467123", "reactome": "R-DME-2889070", "name": "SLC9B2 exchanges Na+, Li+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_2889081" ], "products": [ "species_2889062", "species_163953" ], "modifiers": [ [ "species_10467120", "catalyst" ] ], "additional_components": [ "species_74113", "species_425810", "species_425810", "species_74113", "FBgn0031865" ] }, "reaction_10466257": { "compartment": "compartment_70101", "id": "reaction_10466257", "reactome": "R-DME-2671885", "name": "ASIC trimers:H+ transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10466252", "catalyst" ], [ "species_10466255", "inhibitor" ], [ "species_2672379", "inhibitor" ], [ "species_2672383", "inhibitor" ] ], "additional_components": [ "Q9VJI4", "FBgn0032602", "species_163953", "FBgn0032602" ] }, "reaction_10467025": { "compartment": "compartment_70101", "id": "reaction_10467025", "reactome": "R-DME-2744349", "name": "TTYH1 transports cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10467022", "catalyst" ] ], "additional_components": [ "FBgn0015558" ] }, "reaction_10489584": { "compartment": "compartment_876", "id": "reaction_10489584", "reactome": "R-DME-8863494", "name": "ASICs bind STOML3, (STOM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489580", "species_10466252" ], "products": [ "species_10489582" ], "modifiers": [], "additional_components": [ "Q9VZA4", "FBgn0260657", "Q9VJI4", "FBgn0032602", "species_163953", "Q9VJI4", "FBgn0032602", "species_163953", "Q9VZA4", "FBgn0260657" ] }, "reaction_10467118": { "compartment": "compartment_984", "id": "reaction_10467118", "reactome": "R-DME-2872444", "name": "SLC9B1/C2 exchange Na+ for H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_74113" ], "products": [ "species_351626", "species_83910" ], "modifiers": [ [ "species_10467115", "catalyst" ] ], "additional_components": [ "FBgn0031865" ] }, "reaction_10467020": { "compartment": "compartment_70101", "id": "reaction_10467020", "reactome": "R-DME-2744242", "name": "TTYH2/3 transport cytosolic Cl- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352022" ], "products": [ "species_188972" ], "modifiers": [ [ "species_10467017", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9W5A5", "FBgn0261444", "Q9U6L4", "FBgn0015558" ] }, "reaction_10466793": { "compartment": "compartment_70101", "id": "reaction_10466793", "reactome": "R-DME-2730664", "name": "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10466790", "catalyst" ], [ "species_74016", "inhibitor" ] ], "additional_components": [ "Q9VDY5", "FBgn0038693", "A8JUW5", "FBgn0002917", "Q9VB11", "FBgn0039536" ] }, "reaction_10467080": { "compartment": "compartment_70101", "id": "reaction_10467080", "reactome": "R-DME-2752067", "name": "BESTs transport cytosolic HCO3- to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111627" ], "products": [ "species_425425" ], "modifiers": [ [ "species_10467068", "catalyst" ] ], "additional_components": [ "Q9VUM6", "FBgn0036491", "Q9VRW4", "FBgn0035696", "Q9VUM7", "FBgn0036492" ] }, "reaction_10466592": { "compartment": "compartment_984", "id": "reaction_10466592", "reactome": "R-DME-2672334", "name": "SCNN channels transport extracellular Na+ to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10466589", "catalyst" ], [ "species_2672379", "inhibitor" ] ], "additional_components": [ "Q9W2B5", "FBgn0085398", "Q9W250", "FBgn0034730", "Q9VZN1", "FBgn0035458", "Q9VS73", "FBgn0035785", "Q9VME9", "FBgn0031802", "Q9VME8", "FBgn0031803", "Q9VL88", "FBgn0265001", "Q9VL84", "FBgn0065109", "Q9VBF6", "FBgn0039424", "Q9VAJ7", "FBgn0039675", "Q9VAJ6", "FBgn0039676", "Q9VAJ5", "FBgn0039677", "Q9VAJ3", "FBgn0039679", "Q9V9Y5", "FBgn0039839", "Q8MLR6", "FBgn0050181", "Q8IMV2", "FBgn0051105", "Q86LH3", "FBgn0034489", "Q86LH1", "FBgn0065110", "Q86LG9", "FBgn0053508", "Q86LG7", "FBgn0065108", "Q86LG1", "FBgn0030795", "Q7KTW2", "FBgn0053289", "Q7KT94", "FBgn0020258", "Q0KHW3", "FBgn0052792", "O61365", "FBgn0024319", "A8JV41", "FBgn0030844", "A8JPJ8", "FBgn0051065", "A8DYP1", "FBgn0034965", "A1Z6S4", "FBgn0053349" ] }, "reaction_10489010": { "compartment": "compartment_17938", "id": "reaction_10489010", "reactome": "R-DME-8854329", "name": "TBC1D15 accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10488963" ], "products": [ "species_29372", "species_10489003" ], "modifiers": [ [ "species_10488963", "catalyst" ], [ "species_10489008", "catalyst" ] ], "additional_components": [ "O76742", "FBgn0015795", "species_29438", "O76742", "FBgn0015795", "species_29420", "O76742", "FBgn0015795", "species_29438", "FBgn0031233" ] }, "reaction_10488981": { "compartment": "compartment_262783", "id": "reaction_10488981", "reactome": "R-DME-8854293", "name": "TBC1D10A (EPI64) binds ARF6:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488970", "species_10488977" ], "products": [ "species_10488979" ], "modifiers": [], "additional_components": [ "FBgn0037917", "species_29438", "P40946", "FBgn0013750", "species_29438", "P40946", "FBgn0013750", "Q9VGL8", "FBgn0037917" ] }, "reaction_10488999": { "compartment": "compartment_20699", "id": "reaction_10488999", "reactome": "R-DME-8854303", "name": "TBC1D11 binds RAB6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488142", "species_10488995" ], "products": [ "species_10488997" ], "modifiers": [], "additional_components": [ "O18334", "Rab6", "species_29438", "FBgn0035879", "A8JNN5", "FBgn0035879", "O18334", "Rab6", "species_29438" ] }, "reaction_10488968": { "compartment": "compartment_17938", "id": "reaction_10488968", "reactome": "R-DME-8854255", "name": "TBC1D2A accelerates GTP hydrolysis by RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10488963" ], "products": [ "species_29372", "species_10488965" ], "modifiers": [ [ "species_10488963", "catalyst" ] ], "additional_components": [ "O76742", "FBgn0015795", "species_29438", "O76742", "FBgn0015795", "species_29420", "O76742", "FBgn0015795", "species_29438" ] }, "reaction_10488924": { "compartment": "compartment_24339", "id": "reaction_10488924", "reactome": "R-DME-8854173", "name": "TBC RabGAPs accelerate GTP hydrolysis by RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10488901" ], "products": [ "species_29372", "species_10488903" ], "modifiers": [ [ "species_10488901", "catalyst" ], [ "species_10488922", "catalyst" ] ], "additional_components": [ "Q9W5X0", "FBgn0031090", "species_29438", "Q9W5X0", "FBgn0031090", "species_29420", "Q9W5X0", "FBgn0031090", "species_29438", "Q9VSM8", "FBgn0035916", "Q9VIH7", "FBgn0032901", "Q9VGL8", "FBgn0037917" ] }, "reaction_10488990": { "compartment": "compartment_70101", "id": "reaction_10488990", "reactome": "R-DME-8854302", "name": "TBC1D7 binds the TSC1-TSC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488986", "species_10436942" ], "products": [ "species_10488988" ], "modifiers": [], "additional_components": [ "FBgn0039158", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317", "Q9VCC4", "FBgn0039158" ] }, "reaction_10489038": { "compartment": "compartment_437051", "id": "reaction_10489038", "reactome": "R-DME-8854604", "name": "TBC1D16 accelerates GTP hydrolysis by RAB4A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10489028" ], "products": [ "species_29372", "species_10489030" ], "modifiers": [ [ "species_10489028", "catalyst" ], [ "species_10489036", "catalyst" ] ], "additional_components": [ "Q7KY04", "FBgn0016701", "species_29438", "Q7KY04", "FBgn0016701", "species_29420", "Q7KY04", "FBgn0016701", "species_29438", "FBgn0032249" ] }, "reaction_10489022": { "compartment": "compartment_5683628", "id": "reaction_10489022", "reactome": "R-DME-8854588", "name": "TBC1D25 (OATL1) binds ATG8 homologues", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489018", "species_10476330" ], "products": [ "species_10489020" ], "modifiers": [], "additional_components": [ "FBgn0034009", "FBgn0052672", "Q9W2S2", "FBgn0052672", "Q5BI03", "FBgn0034009" ] }, "reaction_10488959": { "compartment": "compartment_171062", "id": "reaction_10488959", "reactome": "R-DME-8854222", "name": "TBC1D3 associates with RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488927", "species_10488955" ], "products": [ "species_10488957" ], "modifiers": [], "additional_components": [ "FBgn0020620", "species_29438", "Q9V3I2", "FBgn0014010", "Q9W329", "FBgn0030141", "Q9W0H9", "FBgn0262937", "species_29438", "Q9V3I2", "FBgn0014010", "Q9W329", "FBgn0030141", "Q9W0H9", "FBgn0262937", "A1Z9K4", "FBgn0020620" ] }, "reaction_10479983": { "compartment": "compartment_5460", "id": "reaction_10479983", "reactome": "R-DME-6788556", "name": "NUBPL transfers 4Fe-4S to NDUFV1, V2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436354", "species_10477522", "species_76629", "species_10436347" ], "products": [ "species_10477520", "species_10436356", "species_10436349" ], "modifiers": [], "additional_components": [ "FBgn0030853", "Q9V9M8", "FBgn0032986", "FBgn0031771", "FBgn0032986", "Q9VX36", "FBgn0030853", "Q9VMI3", "FBgn0031771", "species_76629" ] }, "reaction_10485760": { "compartment": "compartment_5460", "id": "reaction_10485760", "reactome": "R-DME-6800868", "name": "NDUF subunits bind to form the IP subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436528", "species_10436547", "species_10484249", "species_10436554", "species_10436540" ], "products": [ "species_10484251" ], "modifiers": [], "additional_components": [ "Q9VPE2", "FBgn0037001", "species_113596", "Q9VXK7", "FBgn0030718", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VF27", "FBgn0017567", "FBgn0266582", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596" ] }, "reaction_10484318": { "compartment": "compartment_70616", "id": "reaction_10484318", "reactome": "R-DME-6799191", "name": "Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484277", "species_10436408", "species_10484282", "species_10484270" ], "products": [ "species_10484284" ], "modifiers": [], "additional_components": [ "FBgn0033891", "FBgn0013679", "FBgn0030352", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891" ] }, "reaction_10479981": { "compartment": "compartment_5460", "id": "reaction_10479981", "reactome": "R-DME-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477522", "species_10479977" ], "products": [ "species_10477520", "species_10479979" ], "modifiers": [], "additional_components": [ "Q9V9M8", "FBgn0032986", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q94511", "FBgn0017566", "Q9VXK7", "FBgn0030718", "FBgn0032986", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q94511", "FBgn0017566", "Q9VXK7", "FBgn0030718" ] }, "reaction_10484328": { "compartment": "compartment_5460", "id": "reaction_10484328", "reactome": "R-DME-6799203", "name": "IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484256", "species_10484261", "species_10484266", "species_10484251" ], "products": [ "species_10484268" ], "modifiers": [], "additional_components": [ "FBgn0034919", "FBgn0037777", "FBgn0010340", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919" ] }, "reaction_10484326": { "compartment": "compartment_70616", "id": "reaction_10484326", "reactome": "R-DME-6799202", "name": "The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484305", "species_10484284" ], "products": [ "species_10484307" ], "modifiers": [], "additional_components": [ "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681" ] }, "reaction_10477524": { "compartment": "compartment_5460", "id": "reaction_10477524", "reactome": "R-DME-5690023", "name": "NUBPL binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477520", "species_169274" ], "products": [ "species_10477522" ], "modifiers": [], "additional_components": [ "FBgn0032986", "Q9V9M8", "FBgn0032986" ] }, "reaction_10484324": { "compartment": "compartment_70616", "id": "reaction_10484324", "reactome": "R-DME-6799197", "name": "ND4, ND5 bind the 550kDa complex to form the 815kDa complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436370", "species_10484307", "species_10436365" ], "products": [ "species_10484309" ], "modifiers": [], "additional_components": [ "FBgn0013684", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "FBgn0262952", "P18931", "FBgn0262952", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "P18932", "FBgn0013684" ] }, "reaction_10484322": { "compartment": "compartment_70616", "id": "reaction_10484322", "reactome": "R-DME-6799196", "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484320" ], "products": [ "species_10484256", "species_10484277", "species_10484261", "species_10436566", "species_10484247", "species_10484266", "species_10484282", "species_10484314", "species_10484303" ], "modifiers": [], "additional_components": [ "Q9VMU0", "FBgn0031684", "Q9VMI3", "FBgn0031771", "species_76629", "Q9VWI0", "FBgn0031021", "M9NEW0", "FBgn0263051", "Q94511", "FBgn0017566", "Q9VQD7", "FBgn0031436", "Q9VX36", "FBgn0030853", "P18931", "FBgn0262952", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VYS5", "FBgn0030352", "P18929", "FBgn0013679", "Q7K1S1", "FBgn0033891", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "P18932", "FBgn0013684", "FBgn0034919", "FBgn0033891", "FBgn0037777", "Q9VMU0", "FBgn0031684", "Q9VMI3", "FBgn0031771", "species_76629", "Q9VWI0", "FBgn0031021", "Q94511", "FBgn0017566", "Q9VQD7", "FBgn0031436", "Q9VX36", "FBgn0030853", "P18931", "FBgn0262952", "P18932", "FBgn0013684", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "P18929", "FBgn0013679", "FBgn0037880", "FBgn0010340", "FBgn0030352", "FBgn0263051", "Q9VLM7", "FBgn0032033", "Q9VAI1", "FBgn0039689", "Q9U6M0", "FBgn0028436" ] }, "reaction_10484272": { "compartment": "compartment_70616", "id": "reaction_10484272", "reactome": "R-DME-6799178", "name": "Intermediate 1 binds HP subcomplex to form Intermediate 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436521", "species_10484268" ], "products": [ "species_10484270" ], "modifiers": [], "additional_components": [ "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "species_113596", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VGR2", "FBgn0037880", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "P81928", "FBgn0010340", "Q9VH39", "FBgn0037777", "Q9W1H9", "FBgn0034919", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967" ] }, "reaction_10492180": { "compartment": "compartment_70101", "id": "reaction_10492180", "reactome": "R-DME-8936851", "name": "AHRR binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492174", "species_10458122" ], "products": [ "species_10492178" ], "modifiers": [], "additional_components": [ "FBgn0003513", "FBgn0264075", "O15945", "FBgn0264075", "E1JIM6", "FBgn0003513" ] }, "reaction_10492214": { "compartment": "compartment_70101", "id": "reaction_10492214", "reactome": "R-DME-8937169", "name": "AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492170" ], "products": [ "species_10492212" ], "modifiers": [], "additional_components": [ "E1JIM6", "FBgn0003513", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_8936852", "Q9VH95", "FBgn0037728", "P02828", "FBgn0001233", "E1JIM6", "FBgn0003513", "species_8936852" ] }, "reaction_10492172": { "compartment": "compartment_70101", "id": "reaction_10492172", "reactome": "R-DME-8936849", "name": "AHR:2xHSP90:AIP:PTGES3 binds TCDD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8936852", "species_10492168" ], "products": [ "species_10492170" ], "modifiers": [], "additional_components": [ "E1JIM6", "FBgn0003513", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "E1JIM6", "FBgn0003513", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_8936852" ] }, "reaction_10492220": { "compartment": "compartment_7660", "id": "reaction_10492220", "reactome": "R-DME-8937177", "name": "AHR:TCDD binds ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492216", "species_10458122" ], "products": [ "species_10492218" ], "modifiers": [], "additional_components": [ "species_8936852", "E1JIM6", "FBgn0003513", "FBgn0264075", "O15945", "FBgn0264075", "species_8936852", "E1JIM6", "FBgn0003513" ] }, "reaction_10426932": { "compartment": "compartment_7660", "id": "reaction_10426932", "reactome": "R-DME-68637", "name": "CDC6 protein is synthesized under the control of E2F transcription factors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [], "products": [ "species_10426924" ], "modifiers": [ [ "species_10426928", "catalyst" ] ], "additional_components": [ "FBgn0035918" ] }, "reaction_10426946": { "compartment": "compartment_7660", "id": "reaction_10426946", "reactome": "R-DME-68688", "name": "CDC6 association with ORC:origin complexes mediated by MCM8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426924", "species_10426942" ], "products": [ "species_10426944" ], "modifiers": [], "additional_components": [ "FBgn0035918", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918" ] }, "reaction_10436878": { "compartment": "compartment_5460", "id": "reaction_10436878", "reactome": "R-DME-164834", "name": "Enzyme-bound ATP is released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436872", "species_163953" ], "products": [ "species_10436868", "species_113529", "species_113593" ], "modifiers": [ [ "species_10436872", "catalyst" ] ], "additional_components": [ "species_113592", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_113592", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081" ] }, "reaction_10436875": { "compartment": "compartment_5460", "id": "reaction_10436875", "reactome": "R-DME-164832", "name": "ATPase synthesizes ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436870" ], "products": [ "species_10436872", "species_113521" ], "modifiers": [ [ "species_10436870", "catalyst" ] ], "additional_components": [ "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_29370", "species_29372", "species_113592", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_29370", "species_29372" ] }, "reaction_10436880": { "compartment": "compartment_5460", "id": "reaction_10436880", "reactome": "R-DME-164840", "name": "ADP and Pi bind to ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_10436868" ], "products": [ "species_10436870" ], "modifiers": [], "additional_components": [ "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "species_29370", "species_29372" ] }, "reaction_10442136": { "compartment": "compartment_70101", "id": "reaction_10442136", "reactome": "R-DME-203553", "name": "eNOS binds NOSIP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442132", "species_10441803" ], "products": [ "species_10442134" ], "modifiers": [], "additional_components": [ "FBgn0030915", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VWV8", "FBgn0030915" ] }, "reaction_10442216": { "compartment": "compartment_876", "id": "reaction_10442216", "reactome": "R-DME-203680", "name": "eNOS:NOSIP translocation from caveolae to intracellular compartments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442134" ], "products": [ "species_10442214" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "Q9VWV8", "FBgn0030915", "Q9VWV8", "FBgn0030915", "species_71185", "species_1562550", "species_76629", "species_113596", "species_29870", "Q27571", "FBgn0011676" ] }, "reaction_10442198": { "compartment": "compartment_70101", "id": "reaction_10442198", "reactome": "R-DME-203611", "name": "N-myristoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_184174", "species_10442196" ], "products": [ "species_10441862" ], "modifiers": [], "additional_components": [ "FBgn0011676", "FBgn0011676" ] }, "reaction_10442194": { "compartment": "compartment_20699", "id": "reaction_10442194", "reactome": "R-DME-203567", "name": "palmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441862", "species_200993" ], "products": [ "species_10442144" ], "modifiers": [ [ "species_10442191", "catalyst" ] ], "additional_components": [ "FBgn0011676", "FBgn0011676", "Q9I7L7", "FBgn0042133", "Q9VBM6", "FBgn0039368", "Q9W251", "FBgn0034729", "Q8IQN9", "FBgn0036670", "Q9VBM5", "FBgn0039369", "Q9VBM8", "FBgn0039366", "Q0IGS7", "FBgn0033815", "Q9VBM4", "FBgn0039370", "Q9VBM7", "FBgn0039367" ] }, "reaction_10441870": { "compartment": "compartment_20699", "id": "reaction_10441870", "reactome": "R-DME-202132", "name": "depalmitoylated eNOS translocates from plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441864" ], "products": [ "species_10441868" ], "modifiers": [], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870" ] }, "reaction_10442218": { "compartment": "compartment_20699", "id": "reaction_10442218", "reactome": "R-DME-203700", "name": "eNOS translocation from Golgi to Caveolae", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442144" ], "products": [ "species_10441803" ], "modifiers": [], "additional_components": [ "FBgn0011676", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596" ] }, "reaction_10459882": { "compartment": "compartment_70101", "id": "reaction_10459882", "reactome": "R-DME-1497810", "name": "Uncoupled eNOS favours the formation of superoxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364" ], "products": [ "species_1222424", "species_29366" ], "modifiers": [ [ "species_10459877", "catalyst" ] ], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "species_1497857", "Q8INB9", "phospho-Akt1", "P02828", "FBgn0001233", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10478081": { "compartment": "compartment_876", "id": "reaction_10478081", "reactome": "R-DME-5693373", "name": "DDAH1,2 hydrolyses ADMA to DMA and L-Cit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5693375" ], "products": [ "species_5693410", "species_29968" ], "modifiers": [ [ "species_10478076", "catalyst" ] ], "additional_components": [ "FBgn0030467" ] }, "reaction_10442208": { "compartment": "compartment_876", "id": "reaction_10442208", "reactome": "R-DME-203613", "name": "depalmitoylation of eNOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441803" ], "products": [ "species_76168", "species_10441864" ], "modifiers": [ [ "species_10442205", "catalyst" ] ], "additional_components": [ "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_71185", "species_1562550", "species_76629", "Q27571", "FBgn0011676", "species_113596", "species_29870", "M9PEW1", "FBgn0042138" ] }, "reaction_10434767": { "compartment": "compartment_7660", "id": "reaction_10434767", "reactome": "R-DME-112379", "name": "Recruitment of elongation factors to form elongation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434753", "species_10434721", "species_10434758", "species_10431174", "species_10434681", "species_10434698", "species_10434763", "species_10434686" ], "products": [ "species_10434765" ], "modifiers": [], "additional_components": [ "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "FBgn0030738", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q7JRJ1", "FBgn0033166", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "FBgn0028982", "FBgn0010422", "P20232", "FBgn0010422", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q7JRJ1", "FBgn0033166", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "A8JV07", "FBgn0030738", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637" ] }, "reaction_10475420": { "compartment": "compartment_70101", "id": "reaction_10475420", "reactome": "R-DME-5661290", "name": "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5661268", "species_29360" ], "products": [ "species_70106", "species_5661262", "species_73473" ], "modifiers": [ [ "species_10475417", "catalyst" ] ], "additional_components": [ "Q9VXI1", "FBgn0286508" ] }, "reaction_10475402": { "compartment": "compartment_70101", "id": "reaction_10475402", "reactome": "R-DME-5661240", "name": "DCXR tetramer reduces L-xylulose to xylitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_5660036" ], "products": [ "species_5660033", "species_29366" ], "modifiers": [ [ "species_10475399", "catalyst" ] ], "additional_components": [ "Q9VWP2", "FBgn0030968" ] }, "reaction_10475431": { "compartment": "compartment_70101", "id": "reaction_10475431", "reactome": "R-DME-5662471", "name": "SORD tetramer oxidizes xylitol to D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5660033", "species_29360" ], "products": [ "species_70106", "species_5661281", "species_73473" ], "modifiers": [ [ "species_10474621", "catalyst" ] ], "additional_components": [ "species_1562550", "O96299", "FBgn0022359" ] }, "reaction_10475428": { "compartment": "compartment_70101", "id": "reaction_10475428", "reactome": "R-DME-5662466", "name": "XYLB phosphorylates D-xylulose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_5661281" ], "products": [ "species_29790", "species_29370" ], "modifiers": [ [ "species_10475425", "catalyst" ] ], "additional_components": [ "FBgn0038463" ] }, "reaction_10475410": { "compartment": "compartment_70101", "id": "reaction_10475410", "reactome": "R-DME-5661256", "name": "AKR1A1 reduces D-glucuronate to L-gulonate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_5661264", "species_29364" ], "products": [ "species_29366", "species_5661268" ], "modifiers": [ [ "species_10475407", "catalyst" ] ], "additional_components": [ "FBgn0035476" ] }, "reaction_10454299": { "compartment": "compartment_5460", "id": "reaction_10454299", "reactome": "R-DME-880033", "name": "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_880041" ], "products": [ "species_880046", "species_879997" ], "modifiers": [ [ "species_10454286", "catalyst" ] ], "additional_components": [ "FBgn0017482" ] }, "reaction_10454297": { "compartment": "compartment_5460", "id": "reaction_10454297", "reactome": "R-DME-880007", "name": "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_879997" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10454294", "catalyst" ], [ "species_880069", "catalyst" ], [ "species_880067", "catalyst" ], [ "species_113527", "catalyst" ] ], "additional_components": [ "FBgn0023507" ] }, "reaction_10454307": { "compartment": "compartment_70616", "id": "reaction_10454307", "reactome": "R-DME-880050", "name": "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_880013" ], "products": [ "species_113594", "species_31649" ], "modifiers": [ [ "species_10454304", "catalyst" ] ], "additional_components": [ "FBgn0032729" ] }, "reaction_10479469": { "compartment": "compartment_70101", "id": "reaction_10479469", "reactome": "R-DME-6783221", "name": "HAGH hydrolyses (R)-S-LGSH to GSH and LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694130" ], "products": [ "species_29708", "species_29450" ], "modifiers": [ [ "species_10479466", "catalyst" ] ], "additional_components": [ "species_1562550", "Q8IPU3", "FBgn0037024" ] }, "reaction_10496099": { "compartment": "compartment_5460", "id": "reaction_10496099", "reactome": "R-DME-9011543", "name": "DCA binds PDK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442340", "species_9010792" ], "products": [ "species_10442347" ], "modifiers": [], "additional_components": [ "FBgn0017558", "P91622", "FBgn0017558" ] }, "reaction_10442392": { "compartment": "compartment_5460", "id": "reaction_10442392", "reactome": "R-DME-204169", "name": "PDP dephosphorylates p-lipo-PDH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442333", "species_113521" ], "products": [ "species_10428865", "species_113548" ], "modifiers": [ [ "species_10442389", "catalyst" ], [ "species_109496", "catalyst" ] ], "additional_components": [ "Q9VM14", "FBgn0283658", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "species_113596", "Q9VVL7", "FBgn0036762", "Q9VM14", "FBgn0283658", "species_113596", "Q9VVL7", "FBgn0036762", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "Q9W4K8", "FBgn0029706", "species_113596", "Q9W3Q1", "FBgn0029958" ] }, "reaction_10496106": { "compartment": "compartment_5460", "id": "reaction_10496106", "reactome": "R-DME-9011595", "name": "GSTZ1 dimer dehalogenates DCA to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9010792", "species_113521" ], "products": [ "species_904849", "species_3301973" ], "modifiers": [ [ "species_10496103", "catalyst" ], [ "species_1655887", "catalyst" ], [ "species_9010792", "inhibitor" ] ], "additional_components": [ "Q9VHD2", "FBgn0037697", "species_29450" ] }, "reaction_10496180": { "compartment": "compartment_70101", "id": "reaction_10496180", "reactome": "R-DME-9012036", "name": "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_198498" ], "products": [ "species_70106", "species_113528", "species_29398", "species_29364" ], "modifiers": [ [ "species_10496177", "catalyst" ] ], "additional_components": [ "species_29926", "Q86NT5", "FBgn0029154", "A1ZAF6", "FBgn0029153", "Q9VG31", "FBgn0002719", "E1JIZ4", "FBgn0029155", "Q7K3R0", "FBgn0034127" ] }, "reaction_10486326": { "compartment": "compartment_5460", "id": "reaction_10486326", "reactome": "R-DME-6807826", "name": "LDHAL6B reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113557", "species_29362" ], "products": [ "species_113526", "species_6807616" ], "modifiers": [ [ "species_10486323", "catalyst" ] ], "additional_components": [ "Q95028", "FBgn0001258", "A1Z9F8", "FBgn0033856" ] }, "reaction_10428151": { "compartment": "compartment_70101", "id": "reaction_10428151", "reactome": "R-DME-70510", "name": "LDH tetramer oxidises LACT to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29708", "species_29360" ], "products": [ "species_70106", "species_29398", "species_73473" ], "modifiers": [ [ "species_10428148", "catalyst" ] ], "additional_components": [ "A1Z9F8", "FBgn0033856", "Q95028", "FBgn0001258" ] }, "reaction_10496232": { "compartment": "compartment_70101", "id": "reaction_10496232", "reactome": "R-DME-9012374", "name": "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398" ], "products": [ "species_9012375" ], "modifiers": [ [ "species_10470842", "catalyst" ] ], "additional_components": [ "Q9VKP4", "FBgn0260453", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q94920", "FBgn0004363" ] }, "reaction_10428868": { "compartment": "compartment_5460", "id": "reaction_10428868", "reactome": "R-DME-71397", "name": "lipo-PDH decarboxylates PYR to Ac-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_113557" ], "products": [ "species_113559", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428865", "catalyst" ] ], "additional_components": [ "Q9VM14", "FBgn0283658", "species_113596", "Q9VVL7", "FBgn0036762", "species_8878387", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325" ] }, "reaction_10429155": { "compartment": "compartment_70101", "id": "reaction_10429155", "reactome": "R-DME-71849", "name": "LDH tetramer reduces PYR to LACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29398", "species_73473" ], "products": [ "species_29708", "species_29360" ], "modifiers": [ [ "species_10428148", "catalyst" ] ], "additional_components": [ "A1Z9F8", "FBgn0033856", "Q95028", "FBgn0001258" ] }, "reaction_10478225": { "compartment": "compartment_70101", "id": "reaction_10478225", "reactome": "R-DME-5694071", "name": "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694074", "species_29450" ], "products": [ "species_5694130" ], "modifiers": [ [ "species_10478222", "catalyst" ] ], "additional_components": [ "species_1562550", "A1Z6X6", "FBgn0283450" ] }, "reaction_10496229": { "compartment": "compartment_5460", "id": "reaction_10496229", "reactome": "R-DME-9012349", "name": "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_113544" ], "products": [ "species_113529", "species_113557", "species_113600", "species_29376" ], "modifiers": [ [ "species_10496226", "catalyst" ] ], "additional_components": [ "species_29926", "E1JIZ4", "FBgn0029155" ] }, "reaction_10428534": { "compartment": "compartment_5460", "id": "reaction_10428534", "reactome": "R-DME-70975", "name": "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_113587", "species_113521" ], "products": [ "species_29374", "species_29654" ], "modifiers": [ [ "species_10428531", "catalyst" ] ], "additional_components": [ "Q9W401", "FBgn0261955" ] }, "reaction_10428598": { "compartment": "compartment_5460", "id": "reaction_10428598", "reactome": "R-DME-70997", "name": "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113581" ], "products": [ "species_29374", "species_113593", "species_113536" ], "modifiers": [ [ "species_10428595", "catalyst" ] ], "additional_components": [ "Q94522", "FBgn0004888", "Q95U38", "FBgn0037643" ] }, "reaction_10496201": { "compartment": "compartment_5460", "id": "reaction_10496201", "reactome": "R-DME-9012268", "name": "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544", "species_113526" ], "products": [ "species_113529", "species_113557", "species_29362", "species_29376" ], "modifiers": [ [ "species_10496198", "catalyst" ], [ "species_113588", "catalyst" ], [ "species_113593", "inhibitor" ] ], "additional_components": [ "A1ZAF6", "FBgn0029153", "E1JIZ4", "FBgn0029155", "Q7K3R0", "FBgn0034127", "Q86NT5", "FBgn0029154", "Q9VG31", "FBgn0002719", "species_29926" ] }, "reaction_10496144": { "compartment": "compartment_5460", "id": "reaction_10496144", "reactome": "R-DME-9012016", "name": "FAHD1:Zn2+ dimer hydrolyses OA to PYR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587" ], "products": [ "species_113557", "species_29376" ], "modifiers": [ [ "species_10496141", "catalyst" ] ], "additional_components": [ "Q9VDE2", "FBgn0038858", "species_29926" ] }, "reaction_10428524": { "compartment": "compartment_5460", "id": "reaction_10428524", "reactome": "R-DME-70971", "name": "citrate <=> isocitrate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29654" ], "products": [ "species_29938" ], "modifiers": [ [ "species_10428521", "catalyst" ] ], "additional_components": [ "FBgn0010100" ] }, "reaction_10451212": { "compartment": "compartment_5460", "id": "reaction_10451212", "reactome": "R-DME-451033", "name": "(S)-Malate <=> Fumarate + H2O", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113544" ], "products": [ "species_113588", "species_113521" ], "modifiers": [ [ "species_10428551", "catalyst" ] ], "additional_components": [ "Q9W3X6", "FBgn0286222" ] }, "reaction_10428583": { "compartment": "compartment_5460", "id": "reaction_10428583", "reactome": "R-DME-70994", "name": "Succinate <=> Fumarate (with FAD redox reaction on enzyme)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113536" ], "products": [ "species_113588" ], "modifiers": [ [ "species_10428580", "catalyst" ] ], "additional_components": [ "Q9VGS3", "FBgn0037873", "P21914", "FBgn0014028", "Q9VCI5", "FBgn0039112", "Q94523", "FBgn0261439", "species_113596" ] }, "reaction_10428870": { "compartment": "compartment_5460", "id": "reaction_10428870", "reactome": "R-DME-71401", "name": "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113594", "species_113526" ], "products": [ "species_70958", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428624", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "species_8878387", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10428516": { "compartment": "compartment_5460", "id": "reaction_10428516", "reactome": "R-DME-70967", "name": "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_29938" ], "products": [ "species_113594", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428513", "catalyst" ], [ "species_113581", "catalyst" ] ], "additional_components": [ "Q8MT18", "FBgn0039358", "Q9VD58", "FBgn0038922", "species_266099", "Q9VWH4", "FBgn0027291" ] }, "reaction_10429124": { "compartment": "compartment_5460", "id": "reaction_10429124", "reactome": "R-DME-71783", "name": "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_29362", "species_113587" ], "products": [ "species_113544", "species_113526" ], "modifiers": [ [ "species_10428541", "catalyst" ] ], "additional_components": [ "Q9VEB1", "FBgn0262559" ] }, "reaction_10429122": { "compartment": "compartment_5460", "id": "reaction_10429122", "reactome": "R-DME-71775", "name": "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_113548", "species_113525" ], "products": [ "species_29374", "species_113573", "species_113536" ], "modifiers": [ [ "species_10429119", "catalyst" ] ], "additional_components": [ "Q9V470", "FBgn0029118", "Q94522", "FBgn0004888" ] }, "reaction_10487120": { "compartment": "compartment_20699", "id": "reaction_10487120", "reactome": "R-DME-6811433", "name": "The COG tethering complex interacts with numerous SNAREs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487116", "species_10486635" ], "products": [ "species_10487118" ], "modifiers": [], "additional_components": [ "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q7JY00", "FBgn0037084", "Q9W0N6", "FBgn0260862", "Q9W1I8", "FBgn0034913", "Q9VHB5", "FBgn0261049", "Q9VR90", "FBgn0031106", "Q9VE50", "FBgn0044871", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q7JY00", "FBgn0037084", "Q9W0N6", "FBgn0260862", "Q9W1I8", "FBgn0034913", "Q9VHB5", "FBgn0261049", "Q9VR90", "FBgn0031106", "Q9VE50", "FBgn0044871" ] }, "reaction_10487796": { "compartment": "compartment_20699", "id": "reaction_10487796", "reactome": "R-DME-8847875", "name": "ARF1:GTP binds Golgin TRIP11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461046", "species_10487792" ], "products": [ "species_10487794" ], "modifiers": [], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "A0A4D6K5M0", "FBgn0027287", "A0A4D6K5M0", "FBgn0027287", "P61209", "FBgn0010348", "species_29438" ] }, "reaction_10488246": { "compartment": "compartment_20699", "id": "reaction_10488246", "reactome": "R-DME-8849748", "name": "The COG complex binds RABs at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486635", "species_10488242" ], "products": [ "species_10488244" ], "modifiers": [], "additional_components": [ "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "species_29438", "O18334", "Rab6", "Q9W0A7", "FBgn0035255", "Q9W3Q0", "FBgn0029959", "Q9VM50", "FBgn0031882", "species_29438", "O18334", "Rab6", "Q9W0A7", "FBgn0035255", "Q9W3Q0", "FBgn0029959", "Q9VM50", "FBgn0031882", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401" ] }, "reaction_10487719": { "compartment": "compartment_20699", "id": "reaction_10487719", "reactome": "R-DME-8847637", "name": "NSF and SNAPs bind the cis-SNARE at the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10478727", "species_10487715" ], "products": [ "species_10487717" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9W3M8", "FBgn0260858", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9W3M8", "FBgn0260858", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487815": { "compartment": "compartment_20699", "id": "reaction_10487815", "reactome": "R-DME-8847880", "name": "CYTH proteins bind ARF1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461046", "species_10487801" ], "products": [ "species_10487813" ], "modifiers": [], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "FBgn0086779", "P61209", "FBgn0010348", "species_29438", "Q0E8N2", "FBgn0086779" ] }, "reaction_10487822": { "compartment": "compartment_20699", "id": "reaction_10487822", "reactome": "R-DME-8847883", "name": "CYTH proteins stimulate ARF1 GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487813" ], "products": [ "species_10487819" ], "modifiers": [ [ "species_10487813", "catalyst" ] ], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "Q0E8N2", "FBgn0086779", "P61209", "FBgn0010348", "species_29420", "Q0E8N2", "FBgn0086779", "P61209", "FBgn0010348", "species_29438", "Q0E8N2", "FBgn0086779" ] }, "reaction_10474701": { "compartment": "compartment_17963", "id": "reaction_10474701", "reactome": "R-DME-5653873", "name": "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70113" ], "products": [ "species_964746" ], "modifiers": [ [ "species_10474698", "catalyst" ] ], "additional_components": [ "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047" ] }, "reaction_10474773": { "compartment": "compartment_17963", "id": "reaction_10474773", "reactome": "R-DME-5653878", "name": "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_964746" ], "products": [ "species_5653871", "species_205687" ], "modifiers": [ [ "species_10474770", "catalyst" ] ], "additional_components": [ "Q7KN92", "FBgn0027538", "P83972", "FBgn0004427", "A1ZBX6", "FBgn0034538", "P83971", "FBgn0004426", "A1ZAB8", "FBgn0034092", "P37161", "FBgn0004431", "A1Z9D5", "FBgn0050062", "P37160", "FBgn0004430", "Q9W4C2", "FBgn0029765", "P37159", "FBgn0004428", "Q9VSA5", "FBgn0035813", "P29615", "FBgn0004429", "Q08694", "FBgn0004425", "A1ZBX7", "FBgn0034539" ] }, "reaction_10474803": { "compartment": "compartment_17963", "id": "reaction_10474803", "reactome": "R-DME-5653886", "name": "B4GALT1 binds LALBA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474801", "species_10455850" ], "products": [ "species_10474770" ], "modifiers": [ [ "species_735682", "catalyst" ], [ "species_5653875", "catalyst" ] ], "additional_components": [ "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "FBgn0027538", "Q7KN92", "FBgn0027538", "P83972", "FBgn0004427", "A1ZBX6", "FBgn0034538", "P83971", "FBgn0004426", "A1ZAB8", "FBgn0034092", "P37161", "FBgn0004431", "A1Z9D5", "FBgn0050062", "P37160", "FBgn0004430", "Q9W4C2", "FBgn0029765", "P37159", "FBgn0004428", "Q9VSA5", "FBgn0035813", "P29615", "FBgn0004429", "Q08694", "FBgn0004425", "A1ZBX7", "FBgn0034539" ] }, "reaction_10431982": { "compartment": "compartment_7660", "id": "reaction_10431982", "reactome": "R-DME-75010", "name": "Phosphorylation of Cdc25C at Ser 216 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10431972" ], "products": [ "species_113582", "species_10431980" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "FBgn0261278" ] }, "reaction_10427788": { "compartment": "compartment_7660", "id": "reaction_10427788", "reactome": "R-DME-69604", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427741" ], "products": [ "species_113582", "species_10427778" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "FBgn0261278" ] }, "reaction_10438571": { "compartment": "compartment_7660", "id": "reaction_10438571", "reactome": "R-DME-176250", "name": "Binding of ATR-ATRIP to the RPA-ssDNA complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438544", "species_10438562" ], "products": [ "species_10438569" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438567": { "compartment": "compartment_7660", "id": "reaction_10438567", "reactome": "R-DME-176175", "name": "Stalling of DNA replication fork and RPA binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_176104" ], "products": [ "species_10438544" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438548": { "compartment": "compartment_7660", "id": "reaction_10438548", "reactome": "R-DME-176101", "name": "Recruitment of Rad17-RFC complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438544", "species_10438542" ], "products": [ "species_10438546" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438612": { "compartment": "compartment_7660", "id": "reaction_10438612", "reactome": "R-DME-176318", "name": "Loading of claspin onto DNA during replication origin firing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427361", "species_10438600" ], "products": [ "species_10438602" ], "modifiers": [], "additional_components": [ "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "FBgn0052251", "Q8IRB5", "FBgn0052251", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307" ] }, "reaction_10438595": { "compartment": "compartment_7660", "id": "reaction_10438595", "reactome": "R-DME-176264", "name": "Recruitment of the Rad9-Hus1-Rad1 complex to DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438546", "species_10438590" ], "products": [ "species_10438592" ], "modifiers": [ [ "species_10438546", "catalyst" ] ], "additional_components": [ "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "Q9VQD4", "FBgn0026778", "Q9VN60", "FBgn0026417", "A8JNV5", "FBgn0025807", "Q9VQD4", "FBgn0026778", "Q9VN60", "FBgn0026417", "A8JNV5", "FBgn0025807", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P53034", "FBgn0260985", "O96532", "FBgn0025808", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q9VKW3", "FBgn0032244", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10438610": { "compartment": "compartment_7660", "id": "reaction_10438610", "reactome": "R-DME-176298", "name": "Activation of claspin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438602" ], "products": [ "species_10438608", "species_113582" ], "modifiers": [ [ "species_10438562", "catalyst" ] ], "additional_components": [ "Q8IRB5", "FBgn0052251", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "Q8IRB5", "FBgn0052251", "O96989", "FBgn0026143", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VIE6", "FBgn0032929", "P23573", "FBgn0004107", "Q9VJ90", "FBgn0032677", "Q9NK54", "FBgn0000307", "Q9VVN4", "FBgn0002901", "Q9VXG8", "FBgn0004367" ] }, "reaction_209322": { "compartment": "compartment_7660", "id": "reaction_209322", "reactome": "R-DME-209322", "name": "In the absence of ARM, GRO binds to PAN and inhibits transcription", "reversible": "false", "notes": "In the absence of Armadillo (ARM) due to an active 'destruction complex' removing it in the cytoplasm, the protein Groucho (GRO) binds to Pangolin (PAN) and inhibits transcription.", "reactants": [ "species_205750", "species_205730" ], "products": [ "species_206798" ], "modifiers": [], "additional_components": [ "P91943", "PAN", "P16371", "GRO" ] }, "reaction_10464863": { "compartment": "compartment_161320", "id": "reaction_10464863", "reactome": "R-DME-2105001", "name": "HEXA cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10460515", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10462796": { "compartment": "compartment_984", "id": "reaction_10462796", "reactome": "R-DME-2022056", "name": "DSPG and CSPG translocate to the lysosome for degradation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462724", "species_10462750" ], "products": [ "species_10462776", "species_10462794" ], "modifiers": [], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872" ] }, "reaction_10461387": { "compartment": "compartment_161320", "id": "reaction_10461387", "reactome": "R-DME-1793186", "name": "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2105025" ], "products": [ "species_2104993", "species_1678617" ], "modifiers": [ [ "species_10461298", "catalyst" ] ], "additional_components": [ "FBgn0032343" ] }, "reaction_10497909": { "compartment": "compartment_161320", "id": "reaction_10497909", "reactome": "R-DME-9638075", "name": "HEXB cleaves the terminal GalNAc from DS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065269" ], "products": [ "species_1605658", "species_2105025" ], "modifiers": [ [ "species_10460517", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10461385": { "compartment": "compartment_161320", "id": "reaction_10461385", "reactome": "R-DME-1793182", "name": "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2065213" ], "products": [ "species_2065269", "species_1606845" ], "modifiers": [ [ "species_10461225", "catalyst" ] ], "additional_components": [ "Q9VZP8", "FBgn0035445", "species_74016" ] }, "reaction_10458176": { "compartment": "compartment_70101", "id": "reaction_10458176", "reactome": "R-DME-1236970", "name": "Proteasomal clevage of exogenous antigen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1236719" ], "products": [ "species_8942986", "species_983036" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10497911": { "compartment": "compartment_161320", "id": "reaction_10497911", "reactome": "R-DME-9638076", "name": "HEXB cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10460517", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10465157": { "compartment": "compartment_161320", "id": "reaction_10465157", "reactome": "R-DME-2162227", "name": "GUSB tetramer hydrolyses (HA)2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2160866" ], "products": [ "species_2162223", "species_1678868" ], "modifiers": [ [ "species_10461348", "catalyst" ] ], "additional_components": [ "species_2162224", "A1ZBG9", "FBgn0034417" ] }, "reaction_10465155": { "compartment": "compartment_161320", "id": "reaction_10465155", "reactome": "R-DME-2162226", "name": "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_2162224" ], "products": [ "species_1678743", "species_1678868" ], "modifiers": [ [ "species_10461348", "catalyst" ] ], "additional_components": [ "A1ZBG9", "FBgn0034417" ] }, "reaction_10465153": { "compartment": "compartment_161320", "id": "reaction_10465153", "reactome": "R-DME-2162225", "name": "HEXA cleaves the terminal GalNAc from small HA fragments", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2162223", "species_1605715" ], "products": [ "species_1678743", "species_2162224" ], "modifiers": [ [ "species_10460515", "catalyst" ] ], "additional_components": [ "Q9W3C4", "FBgn0041629", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630" ] }, "reaction_10438422": { "compartment": "compartment_70101", "id": "reaction_10438422", "reactome": "R-DME-174392", "name": "PAPSS1,2 transfer SO4(2-) group to ATP to form APS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174375" ], "products": [ "species_111294", "species_174370" ], "modifiers": [ [ "species_10438414", "catalyst" ] ], "additional_components": [ "FBgn0020389" ] }, "reaction_10438419": { "compartment": "compartment_70101", "id": "reaction_10438419", "reactome": "R-DME-174389", "name": "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_174370" ], "products": [ "species_29370", "species_158471" ], "modifiers": [ [ "species_10438414", "catalyst" ] ], "additional_components": [ "FBgn0020389" ] }, "reaction_10461983": { "compartment": "compartment_20699", "id": "reaction_10461983", "reactome": "R-DME-1889955", "name": "B3GAT dimers transfer GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10461911" ], "products": [ "species_10461945", "species_205687" ], "modifiers": [ [ "species_10461980", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "O97422", "FBgn0066114", "Q9VTG7", "FBgn0036144", "Q9VLA1", "FBgn0032135", "species_266099" ] }, "reaction_10497906": { "compartment": "compartment_20699", "id": "reaction_10497906", "reactome": "R-DME-9638064", "name": "B3GAT3 dimer transfers GlcA to tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10461911" ], "products": [ "species_10461945", "species_205687" ], "modifiers": [ [ "species_10461978", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "O97422", "FBgn0066114", "species_266099" ] }, "reaction_10462025": { "compartment": "compartment_20699", "id": "reaction_10462025", "reactome": "R-DME-1889978", "name": "B3GALT6 transfers Gal to the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462017", "species_735682" ], "products": [ "species_10461911", "species_205687" ], "modifiers": [ [ "species_10462022", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "FBgn0033315" ] }, "reaction_10461877": { "compartment": "compartment_20699", "id": "reaction_10461877", "reactome": "R-DME-1878002", "name": "XYLTs transfer Xyl to core protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461833", "species_742361" ], "products": [ "species_10461867", "species_205687" ], "modifiers": [ [ "species_10461872", "catalyst" ] ], "additional_components": [ "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q24114", "dally", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "FBgn0015360" ] }, "reaction_10462033": { "compartment": "compartment_20699", "id": "reaction_10462033", "reactome": "R-DME-1889981", "name": "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735682", "species_10461867" ], "products": [ "species_10462017", "species_205687" ], "modifiers": [ [ "species_10462030", "catalyst" ] ], "additional_components": [ "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "Q24114", "dally", "M9MSI4", "FBgn0028872", "Q9VUG1", "FBgn0041604", "Q24567", "FBgn0015773", "P49415", "FBgn0010415", "FBgn0039258" ] }, "reaction_10462812": { "compartment": "compartment_20699", "id": "reaction_10462812", "reactome": "R-DME-2022061", "name": "Dermatan sulfate can be further sulfated on position 2 of iduronate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10462684" ], "products": [ "species_742343", "species_10462804" ], "modifiers": [ [ "species_10462809", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "FBgn0003089" ] }, "reaction_10462828": { "compartment": "compartment_17963", "id": "reaction_10462828", "reactome": "R-DME-2022065", "name": "DSPGs are secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462826" ], "products": [ "species_10462724" ], "modifiers": [], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872" ] }, "reaction_10462415": { "compartment": "compartment_20699", "id": "reaction_10462415", "reactome": "R-DME-1971483", "name": "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10462365" ], "products": [ "species_742343", "species_10462375" ], "modifiers": [ [ "species_10462412", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VMS3", "FBgn0031697", "Q9VJG5", "FBgn0032618", "Q8IRG5", "FBgn0035287" ] }, "reaction_10463695": { "compartment": "compartment_17963", "id": "reaction_10463695", "reactome": "R-DME-2022911", "name": "CSPG is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10463693" ], "products": [ "species_10462750" ], "modifiers": [], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872" ] }, "reaction_10462445": { "compartment": "compartment_20699", "id": "reaction_10462445", "reactome": "R-DME-1971491", "name": "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10462345" ], "products": [ "species_10462425", "species_205687" ], "modifiers": [ [ "species_10462437", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VYH2", "FBgn0263005", "Q7KUZ9", "FBgn0030662" ] }, "reaction_10462440": { "compartment": "compartment_20699", "id": "reaction_10462440", "reactome": "R-DME-1971487", "name": "CHPF,CHSY3 transfer GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10462425" ], "products": [ "species_205687", "species_10462365" ], "modifiers": [ [ "species_10462437", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VYH2", "FBgn0263005", "Q7KUZ9", "FBgn0030662" ] }, "reaction_10462355": { "compartment": "compartment_20699", "id": "reaction_10462355", "reactome": "R-DME-1971482", "name": "The addition of GalNAc to the terminal glucuronate residue forms chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10462335" ], "products": [ "species_10462345", "species_205687" ], "modifiers": [ [ "species_10462350", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "FBgn0033500" ] }, "reaction_10497804": { "compartment": "compartment_20699", "id": "reaction_10497804", "reactome": "R-DME-9632033", "name": "CHSY1 transfers GalNAc to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_735700", "species_10462425" ], "products": [ "species_205687", "species_10462365" ], "modifiers": [ [ "species_10497801", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "FBgn0030662" ] }, "reaction_10497807": { "compartment": "compartment_20699", "id": "reaction_10497807", "reactome": "R-DME-9632034", "name": "CHSY1 transfers GlcA to chondroitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1889970", "species_10462345" ], "products": [ "species_10462425", "species_205687" ], "modifiers": [ [ "species_10497801", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "FBgn0030662" ] }, "reaction_10462672": { "compartment": "compartment_20699", "id": "reaction_10462672", "reactome": "R-DME-2018682", "name": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_741440", "species_10462365" ], "products": [ "species_742343", "species_10462649" ], "modifiers": [ [ "species_10462669", "catalyst" ] ], "additional_components": [ "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VJ82", "FBgn0032683", "M9MSI4", "FBgn0028872", "Q9VMC4", "FBgn0031826", "Q9VMC3", "FBgn0051637" ] }, "reaction_10461519": { "compartment": "compartment_70101", "id": "reaction_10461519", "reactome": "R-DME-1855154", "name": "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_870330" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10461516", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUW3", "FBgn0036553", "Q7KTW5", "FBgn0037063", "Q9VUW2", "FBgn0036553", "Q9VUW1", "FBgn0036550", "Q9VUW4", "FBgn0036553", "Q9VP62", "FBgn0037064" ] }, "reaction_10461647": { "compartment": "compartment_70101", "id": "reaction_10461647", "reactome": "R-DME-1855202", "name": "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629746" ], "products": [ "species_29372", "species_1629731" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10461723": { "compartment": "compartment_876", "id": "reaction_10461723", "reactome": "R-DME-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10461720", "catalyst" ] ], "additional_components": [ "O46094", "FBgn0023508", "B7Z0Q2", "FBgn0259178" ] }, "reaction_10461611": { "compartment": "compartment_70101", "id": "reaction_10461611", "reactome": "R-DME-1855180", "name": "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629769" ], "modifiers": [ [ "species_10461193", "catalyst" ] ], "additional_components": [ "FBgn0259166" ] }, "reaction_10461674": { "compartment": "compartment_70101", "id": "reaction_10461674", "reactome": "R-DME-1855211", "name": "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629753" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10461516", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUW3", "FBgn0036553", "Q7KTW5", "FBgn0037063", "Q9VUW2", "FBgn0036553", "Q9VUW1", "FBgn0036550", "Q9VUW4", "FBgn0036553", "Q9VP62", "FBgn0037064" ] }, "reaction_10476185": { "compartment": "compartment_70101", "id": "reaction_10476185", "reactome": "R-DME-5678327", "name": "MIOX oxidises Ins to GlcA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_426910" ], "products": [ "species_29356", "species_70106", "species_2162232" ], "modifiers": [ [ "species_10476182", "catalyst" ] ], "additional_components": [ "species_111793", "Q9VTU9", "FBgn0036262" ] }, "reaction_10461671": { "compartment": "compartment_70101", "id": "reaction_10461671", "reactome": "R-DME-1855210", "name": "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629731" ], "products": [ "species_29372", "species_426910" ], "modifiers": [ [ "species_10461516", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUW3", "FBgn0036553", "Q7KTW5", "FBgn0037063", "Q9VUW2", "FBgn0036553", "Q9VUW1", "FBgn0036550", "Q9VUW4", "FBgn0036553", "Q9VP62", "FBgn0037064" ] }, "reaction_10461572": { "compartment": "compartment_70101", "id": "reaction_10461572", "reactome": "R-DME-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_114520" ], "products": [ "species_29372", "species_1629739" ], "modifiers": [ [ "species_10461569", "catalyst" ] ], "additional_components": [ "M9PHS8", "FBgn0030761", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10461668": { "compartment": "compartment_70101", "id": "reaction_10461668", "reactome": "R-DME-1855208", "name": "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1629739" ], "products": [ "species_29372", "species_1629753" ], "modifiers": [ [ "species_10461665", "catalyst" ] ], "additional_components": [ "Q9VFP6", "FBgn0016672", "species_29926" ] }, "reaction_10461603": { "compartment": "compartment_70101", "id": "reaction_10461603", "reactome": "R-DME-1855178", "name": "Glc6P is isomerised to I3P by ISYNA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629756" ], "products": [ "species_1629731" ], "modifiers": [ [ "species_10461600", "catalyst" ] ], "additional_components": [ "species_427523", "O97477", "FBgn0025885" ] }, "reaction_10461744": { "compartment": "compartment_70101", "id": "reaction_10461744", "reactome": "R-DME-1855232", "name": "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_994123" ], "products": [ "species_29372", "species_1629746" ], "modifiers": [ [ "species_10461665", "catalyst" ] ], "additional_components": [ "Q9VFP6", "FBgn0016672", "species_29926" ] }, "reaction_10435903": { "compartment": "compartment_13959", "id": "reaction_10435903", "reactome": "R-DME-159783", "name": "Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435829" ], "products": [ "species_10435901" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10435817": { "compartment": "compartment_13959", "id": "reaction_10435817", "reactome": "R-DME-159757", "name": "Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435815" ], "products": [ "species_10435779" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10436713": { "compartment": "compartment_13959", "id": "reaction_10436713", "reactome": "R-DME-163825", "name": "Gamma-carboxy pro-protein Z transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436709" ], "products": [ "species_10436663" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459" ] }, "reaction_10436697": { "compartment": "compartment_13959", "id": "reaction_10436697", "reactome": "R-DME-163809", "name": "Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436693" ], "products": [ "species_10436695" ], "modifiers": [], "additional_components": [ "FBgn0027594", "FBgn0027594" ] }, "reaction_10435879": { "compartment": "compartment_13959", "id": "reaction_10435879", "reactome": "R-DME-159762", "name": "Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435863" ], "products": [ "species_10435877" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10435972": { "compartment": "compartment_13959", "id": "reaction_10435972", "reactome": "R-DME-159836", "name": "Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435958" ], "products": [ "species_10435932" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10473803": { "compartment": "compartment_876", "id": "reaction_10473803", "reactome": "R-DME-5624126", "name": "ARL6:GTP and the BBSome bind ciliary cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473254", "species_10473799", "species_10473785" ], "products": [ "species_10473801" ], "modifiers": [], "additional_components": [ "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "A1ZBK9", "FBgn0034446", "species_29438", "A1ZBK9", "FBgn0034446", "species_29438", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280" ] }, "reaction_10473835": { "compartment": "compartment_261122", "id": "reaction_10473835", "reactome": "R-DME-5624127", "name": "ARL6:GTP and the BBSome target cargo to the primary cilium", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473801" ], "products": [ "species_10473833" ], "modifiers": [], "additional_components": [ "A1ZBK9", "FBgn0034446", "species_29438", "Q9VTU7", "FBgn0036260", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280", "species_29438", "A1ZBK9", "FBgn0034446", "Q9VPP9", "FBgn0031255", "A1Z8E9", "FBgn0033578", "B7YZM8", "FBgn0034622", "Q9VS19", "FBgn0035741", "E1JIG6", "FBgn0260237", "Q9I7P3", "FBgn0037280", "Q9U721", "FBgn0266429", "A0A0S0WMT8", "FBgn0036789", "Q9VVQ1", "FBgn0036790", "Q9VTU7", "FBgn0036260" ] }, "reaction_10488803": { "compartment": "compartment_984", "id": "reaction_10488803", "reactome": "R-DME-8852809", "name": "CPN, CPB2 cleave C3a, C5a", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488798" ], "products": [ "species_10488800" ], "modifiers": [ [ "species_10464252", "catalyst" ] ], "additional_components": [ "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VCM8", "FBgn0039073", "Q961J8", "FBgn0035781", "Q7JYV3", "FBgn0033774", "Q9W478", "FBgn0029804", "Q0E9F9", "FBgn0033241", "Q9W477", "FBgn0259149", "M9PEV1", "FBgn0035776", "Q9W475", "FBgn0029807", "Q9VX86", "FBgn0030815", "Q9VS80", "FBgn0035791", "Q9VS67", "FBgn0035780", "Q9VS66", "FBgn0035779", "Q9VS65", "FBgn0052379", "Q9VS64", "FBgn0035777", "Q9VRZ3", "FBgn0035718", "Q9VLZ2", "FBgn0031929", "Q9VLZ1", "FBgn0031930", "Q9VL87", "FBgn0032143", "Q9VL86", "FBgn0032144" ] }, "reaction_10455979": { "compartment": "compartment_984", "id": "reaction_10455979", "reactome": "R-DME-976801", "name": "Complement factor I complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455955", "species_10455975" ], "products": [ "species_10455977" ], "modifiers": [], "additional_components": [ "A1Z7M3", "FBgn0265011", "A8DY75", "FBgn0033362", "Q9VRS5", "FBgn0035663", "A1Z709", "FBgn0033192", "A1Z7M7", "FBgn0033365", "Q05319", "FBgn0003319", "A1Z7M5", "FBgn0033363", "B7YZU2", "FBgn0286782", "Q9VZH5", "FBgn0035501", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319" ] }, "reaction_10457578": { "compartment": "compartment_876", "id": "reaction_10457578", "reactome": "R-DME-1006143", "name": "CD46 binds C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456081", "species_10456083" ], "products": [ "species_10456085" ], "modifiers": [], "additional_components": [ "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10467082": { "compartment": "compartment_984", "id": "reaction_10467082", "reactome": "R-DME-2855047", "name": "Hydrolysis of internal thioester in C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10437245" ], "products": [ "species_10456099" ], "modifiers": [], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488" ] }, "reaction_10493671": { "compartment": "compartment_876", "id": "reaction_10493671", "reactome": "R-DME-8951486", "name": "CD46 binds C4b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456081", "species_10456122" ], "products": [ "species_10456124" ], "modifiers": [], "additional_components": [ "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10456231": { "compartment": "compartment_876", "id": "reaction_10456231", "reactome": "R-DME-977615", "name": "Factor I inactivates MCP/CR1-bound C4b/C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456132" ], "products": [ "species_10456228", "species_10455977", "species_10456186", "species_10456188" ], "modifiers": [ [ "species_10456132", "catalyst" ] ], "additional_components": [ "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10456134": { "compartment": "compartment_876", "id": "reaction_10456134", "reactome": "R-DME-977602", "name": "Complement factor I binds to MCP, CR1:C4b, C3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456130", "species_10455977" ], "products": [ "species_10456132" ], "modifiers": [], "additional_components": [ "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10468164": { "compartment": "compartment_876", "id": "reaction_10468164", "reactome": "R-DME-3266557", "name": "Factor I cleaves iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468123" ], "products": [ "species_10468161", "species_10468149", "species_10456075" ], "modifiers": [ [ "species_10455977", "catalyst" ] ], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "B7YZU2", "FBgn0286782", "A8DY75", "FBgn0033362", "A1Z7M7", "FBgn0033365", "A1Z7M5", "FBgn0033363", "A1Z7M3", "FBgn0265011", "A1Z709", "FBgn0033192", "Q9VZH5", "FBgn0035501", "Q9VRS5", "FBgn0035663", "Q05319", "FBgn0003319" ] }, "reaction_10488811": { "compartment": "compartment_876", "id": "reaction_10488811", "reactome": "R-DME-8852874", "name": "CR2 binds C3d, C3dg, iC3b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488807", "species_10488805" ], "products": [ "species_10488809" ], "modifiers": [], "additional_components": [ "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "FBgn0001083", "Q9VYR4", "FBgn0001083", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180" ] }, "reaction_10459709": { "compartment": "compartment_12045", "id": "reaction_10459709", "reactome": "R-DME-1482889", "name": "DAG is acylated to TAG by DGAT1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10459706", "catalyst" ] ], "additional_components": [ "Q960U8", "FBgn0004797", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216", "Q7K1C2", "FBgn0033215" ] }, "reaction_10479149": { "compartment": "compartment_12045", "id": "reaction_10479149", "reactome": "R-DME-5696448", "name": "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696449", "species_6782195" ], "products": [ "species_76194", "species_1500596" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10459644": { "compartment": "compartment_12045", "id": "reaction_10459644", "reactome": "R-DME-1482654", "name": "2-MAG is transacylated to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728" ], "products": [ "species_76116", "species_1500596" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10459642": { "compartment": "compartment_12045", "id": "reaction_10459642", "reactome": "R-DME-1482647", "name": "2-MAG and DAG are transacylated to TAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498728", "species_1500596" ], "products": [ "species_76116", "species_1500594" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10459672": { "compartment": "compartment_12045", "id": "reaction_10459672", "reactome": "R-DME-1482777", "name": "TAG is hydrolyzed to DAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500594" ], "products": [ "species_1524021", "species_1500596" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10459686": { "compartment": "compartment_12045", "id": "reaction_10459686", "reactome": "R-DME-1482811", "name": "DAG is hydrolyzed to 2-MAG by PNPLA2/3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500596" ], "products": [ "species_1498728", "species_1524021" ], "modifiers": [ [ "species_10459639", "catalyst" ] ], "additional_components": [ "E1JI03", "FBgn0036449", "Q9VXY8", "FBgn0030607" ] }, "reaction_10487933": { "compartment": "compartment_12045", "id": "reaction_10487933", "reactome": "R-DME-8848580", "name": "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1500596" ], "products": [ "species_1500594", "species_76194" ], "modifiers": [ [ "species_10487930", "catalyst" ] ], "additional_components": [ "A1Z739", "FBgn0033216", "Q7JYK2", "FBgn0033214", "Q7K1C2", "FBgn0033215" ] }, "reaction_10459690": { "compartment": "compartment_70616", "id": "reaction_10459690", "reactome": "R-DME-1482850", "name": "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524083", "species_1498773" ], "products": [ "species_1524072", "species_1524089" ], "modifiers": [ [ "species_10459677", "catalyst" ] ], "additional_components": [ "FBgn0026619" ] }, "reaction_10459683": { "compartment": "compartment_70616", "id": "reaction_10459683", "reactome": "R-DME-1482794", "name": "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524072", "species_1524079" ], "products": [ "species_1524075", "species_1498773" ], "modifiers": [ [ "species_10459677", "catalyst" ] ], "additional_components": [ "FBgn0026619" ] }, "reaction_10459667": { "compartment": "compartment_70616", "id": "reaction_10459667", "reactome": "R-DME-1482775", "name": "MLCL is acylated to CL by HADH (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498773", "species_1524038" ], "products": [ "species_1524072", "species_29374" ], "modifiers": [ [ "species_10459664", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10479135": { "compartment": "compartment_5460", "id": "reaction_10479135", "reactome": "R-DME-5696415", "name": "PXLP-K278-ETNPPL tetramer hydrolyses PETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696414", "species_113521" ], "products": [ "species_113548", "species_113532", "species_5693978" ], "modifiers": [ [ "species_10479132", "catalyst" ] ], "additional_components": [ "Q9VU95", "FBgn0036381" ] }, "reaction_10459804": { "compartment": "compartment_70101", "id": "reaction_10459804", "reactome": "R-DME-1483096", "name": "PETA is dephosphorylated to ETA by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_428686" ], "products": [ "species_29372", "species_1498751" ], "modifiers": [ [ "species_10459801", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VWF3", "FBgn0031045", "Q9VWF0", "FBgn0031048" ] }, "reaction_10459850": { "compartment": "compartment_12045", "id": "reaction_10459850", "reactome": "R-DME-1483190", "name": "PETA and CTP are condensed to CDP-ETA by PCY2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_428686", "species_110614" ], "products": [ "species_111294", "species_1500603" ], "modifiers": [ [ "species_10459847", "catalyst" ] ], "additional_components": [ "Q9VK25", "FBgn0032482" ] }, "reaction_10459861": { "compartment": "compartment_12045", "id": "reaction_10459861", "reactome": "R-DME-1483203", "name": "PA is dephosphorylated to DAG by LPIN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_29372", "species_1500596" ], "modifiers": [ [ "species_10459858", "catalyst" ] ], "additional_components": [ "species_29926", "Q8SXP0", "FBgn0263593" ] }, "reaction_10459733": { "compartment": "compartment_12045", "id": "reaction_10459733", "reactome": "R-DME-1482962", "name": "CDP-ETA and DAG are converted to PE by CEPT1/EPT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500603", "species_1500596" ], "products": [ "species_1500581", "species_109395" ], "modifiers": [ [ "species_10459730", "catalyst" ] ], "additional_components": [ "species_29926", "species_266099", "Q9VIU4", "FBgn0053116", "Q8T0S3", "FBgn0031948" ] }, "reaction_10459873": { "compartment": "compartment_70101", "id": "reaction_10459873", "reactome": "R-DME-1483222", "name": "ETA is phosphorylated to PETA by CHK/ETNK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1498751" ], "products": [ "species_29370", "species_428686" ], "modifiers": [ [ "species_10459870", "catalyst" ] ], "additional_components": [ "Q8IMF4", "FBgn0032955", "P54352", "FBgn0000536" ] }, "reaction_10459743": { "compartment": "compartment_12045", "id": "reaction_10459743", "reactome": "R-DME-1482976", "name": "CDP-DAG is converted to PI by CDIPT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426955", "species_426910" ], "products": [ "species_426639", "species_109395" ], "modifiers": [ [ "species_10459740", "catalyst" ] ], "additional_components": [ "Q8SX37", "FBgn0030670", "species_29926", "species_266099" ] }, "reaction_10459814": { "compartment": "compartment_12045", "id": "reaction_10459814", "reactome": "R-DME-1483121", "name": "PA is converted to CDP-DAG by CDS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_426755" ], "products": [ "species_111294", "species_426955" ], "modifiers": [ [ "species_10459811", "catalyst" ] ], "additional_components": [ "species_29926", "P56079", "FBgn0010350" ] }, "reaction_10490382": { "compartment": "compartment_70101", "id": "reaction_10490382", "reactome": "R-DME-8869241", "name": "PITPNM1,2,3 exchange PI for PA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426639", "species_1602448" ], "products": [ "species_426755", "species_426658" ], "modifiers": [ [ "species_10490379", "catalyst" ] ], "additional_components": [ "P43125", "FBgn0003218", "Q9VLS7", "FBgn0031990" ] }, "reaction_10459764": { "compartment": "compartment_70616", "id": "reaction_10459764", "reactome": "R-DME-1483063", "name": "PG and CDP-DAG are converted to CL by CRLS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524042", "species_1524064" ], "products": [ "species_1524072", "species_1524067" ], "modifiers": [ [ "species_10459585", "catalyst" ] ], "additional_components": [ "FBgn0039360" ] }, "reaction_10479092": { "compartment": "compartment_17906", "id": "reaction_10479092", "reactome": "R-DME-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696066", "species_5696069" ], "products": [ "species_5696026", "species_5696037" ], "modifiers": [ [ "species_10479089", "catalyst" ] ], "additional_components": [ "species_5696449", "species_114519", "species_1500590", "species_417891", "Q9VL10", "FBgn0260750", "species_29926" ] }, "reaction_10459840": { "compartment": "compartment_12045", "id": "reaction_10459840", "reactome": "R-DME-1483186", "name": "PC is converted to PS by PTDSS1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_200736" ], "products": [ "species_264618", "species_1500646" ], "modifiers": [ [ "species_10459837", "catalyst" ] ], "additional_components": [ "FBgn0287585" ] }, "reaction_10490948": { "compartment": "compartment_12045", "id": "reaction_10490948", "reactome": "R-DME-8874435", "name": "THEM86B hydrolyses PMCHO, PMETAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_8874447" ], "products": [ "species_8874450", "species_5696116" ], "modifiers": [ [ "species_10490945", "catalyst" ] ], "additional_components": [ "CHEBI:17810", "CHEBI:17476", "CHEBI:36313", "CHEBI:36314", "FBgn0039681" ] }, "reaction_10459577": { "compartment": "compartment_12045", "id": "reaction_10459577", "reactome": "R-DME-1482533", "name": "2-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_975614" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10459574", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q0KHU5", "FBgn0052699", "Q6NN55", "FBgn0033476" ] }, "reaction_10459688": { "compartment": "compartment_12045", "id": "reaction_10459688", "reactome": "R-DME-1482816", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[6]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10460328": { "compartment": "compartment_984", "id": "reaction_10460328", "reactome": "R-DME-1602417", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10460293", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9W3I8", "FBgn0030013", "Q9VYG9", "FBgn0250862", "Q7JX94", "FBgn0050503", "Q9W4I0", "FBgn0029720", "Q6XPX3", "FBgn0033170", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459591": { "compartment": "compartment_12045", "id": "reaction_10459591", "reactome": "R-DME-1482547", "name": "1-acyl LPC is acylated to PC by LPCAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524028", "species_1500578" ], "products": [ "species_426925", "species_76194" ], "modifiers": [ [ "species_10459574", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q0KHU5", "FBgn0052699", "Q6NN55", "FBgn0033476" ] }, "reaction_10460326": { "compartment": "compartment_984", "id": "reaction_10460326", "reactome": "R-DME-1602399", "name": "PC is hydrolyzed to 1-acyl LPC by PLB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_429802" ], "products": [ "species_1602390", "species_1602366" ], "modifiers": [ [ "species_10455770", "catalyst" ] ], "additional_components": [ "FBgn0036939" ] }, "reaction_10459698": { "compartment": "compartment_12045", "id": "reaction_10459698", "reactome": "R-DME-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_1524028", "species_1524021" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10459613": { "compartment": "compartment_12045", "id": "reaction_10459613", "reactome": "R-DME-1482635", "name": "2-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498730", "species_1500578" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10432542", "catalyst" ] ], "additional_components": [ "FBgn0052699" ] }, "reaction_10459580": { "compartment": "compartment_12045", "id": "reaction_10459580", "reactome": "R-DME-1482539", "name": "1-acyl LPG is acylated to PG by LPGAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498740" ], "products": [ "species_1483256", "species_76194" ], "modifiers": [ [ "species_10432542", "catalyst" ] ], "additional_components": [ "FBgn0052699" ] }, "reaction_10459658": { "compartment": "compartment_70616", "id": "reaction_10459658", "reactome": "R-DME-1482689", "name": "1-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524027", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10459585", "catalyst" ] ], "additional_components": [ "FBgn0039360" ] }, "reaction_10460313": { "compartment": "compartment_984", "id": "reaction_10460313", "reactome": "R-DME-1602368", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602402" ], "products": [ "species_1602415", "species_1602366" ], "modifiers": [ [ "species_10460293", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9W3I8", "FBgn0030013", "Q9VYG9", "FBgn0250862", "Q7JX94", "FBgn0050503", "Q9W4I0", "FBgn0029720", "Q6XPX3", "FBgn0033170", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459716": { "compartment": "compartment_12045", "id": "reaction_10459716", "reactome": "R-DME-1482907", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10459588": { "compartment": "compartment_70616", "id": "reaction_10459588", "reactome": "R-DME-1482546", "name": "2-acyl LPG is acylated to PG by CRLS1 (IM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1524047", "species_1524038" ], "products": [ "species_29374", "species_1524042" ], "modifiers": [ [ "species_10459585", "catalyst" ] ], "additional_components": [ "FBgn0039360" ] }, "reaction_10459714": { "compartment": "compartment_12045", "id": "reaction_10459714", "reactome": "R-DME-1482900", "name": "PG is hydrolyzed to 1-acyl LPG by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1483256", "species_29356" ], "products": [ "species_1524021", "species_1498740" ], "modifiers": [ [ "species_10459604", "catalyst" ] ], "additional_components": [ "FBgn0039655" ] }, "reaction_10459599": { "compartment": "compartment_12045", "id": "reaction_10459599", "reactome": "R-DME-1482598", "name": "1-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498733", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10459596", "catalyst" ] ], "additional_components": [ "FBgn0031815" ] }, "reaction_10459610": { "compartment": "compartment_12045", "id": "reaction_10459610", "reactome": "R-DME-1482626", "name": "2-acyl LPI is acylated to PI by MBOAT7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498737", "species_1500578" ], "products": [ "species_426639", "species_76194" ], "modifiers": [ [ "species_10459596", "catalyst" ] ], "additional_components": [ "FBgn0031815" ] }, "reaction_10459700": { "compartment": "compartment_12045", "id": "reaction_10459700", "reactome": "R-DME-1482868", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[12]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426639" ], "products": [ "species_1498733", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10460321": { "compartment": "compartment_984", "id": "reaction_10460321", "reactome": "R-DME-1602377", "name": "PI is hydrolyzed to 1-acyl LPI by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_426658" ], "products": [ "species_1602420", "species_1602366" ], "modifiers": [ [ "species_10460316", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459646": { "compartment": "compartment_70101", "id": "reaction_10459646", "reactome": "R-DME-1482656", "name": "PA is hydrolysed to 1-acyl LPA by PLA2[1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10459604", "catalyst" ] ], "additional_components": [ "FBgn0039655" ] }, "reaction_10459832": { "compartment": "compartment_12045", "id": "reaction_10459832", "reactome": "R-DME-1483182", "name": "PC is hydrolyzed to PA and choline by PLD1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_264618", "species_426755" ], "modifiers": [ [ "species_10459827", "catalyst" ] ], "additional_components": [ "FBgn0286511" ] }, "reaction_10459607": { "compartment": "compartment_17906", "id": "reaction_10459607", "reactome": "R-DME-1482604", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500590" ], "products": [ "species_1500580", "species_1524103" ], "modifiers": [ [ "species_10459604", "catalyst" ] ], "additional_components": [ "FBgn0039655" ] }, "reaction_10481009": { "compartment": "compartment_876", "id": "reaction_10481009", "reactome": "R-DME-6792445", "name": "LIPH, I hydrolyse PA to 2-acyl LPA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_6792472", "species_1602366" ], "modifiers": [ [ "species_10481006", "catalyst" ] ], "additional_components": [ "Q9VU78", "FBgn0036367", "Q9VRW5", "FBgn0035697", "Q9VLU1", "FBgn0031976", "Q9VJH1", "FBgn0032612", "Q9VEY9", "FBgn0038398", "Q9VBQ2", "FBgn0039344", "Q9VB94", "FBgn0039470", "Q9VB93", "FBgn0039471", "Q9VB92", "FBgn0039472", "Q9VB91", "FBgn0039473", "Q9VB90", "FBgn0039474", "Q9VB89", "FBgn0039475", "Q9VB88", "FBgn0039476", "Q7K3Z8", "FBgn0032029", "Q4V566", "FBgn0085476", "Q0E8T1", "FBgn0250847", "P06607", "FBgn0004047", "P02844", "FBgn0005391", "P02843", "FBgn0004045", "M9NFL7", "FBgn0036977", "M9MRT1", "FBgn0032289", "A8DYT7", "FBgn0085477", "A1ZAL5", "FBgn0034166", "Q9W448", "FBgn0029831", "Q9W304", "FBgn0030162", "Q9VZN6", "FBgn0035453", "Q9VX70", "FBgn0265267", "Q9VX69", "FBgn0030828", "Q9VX01", "FBgn0030884" ] }, "reaction_10453360": { "compartment": "compartment_12045", "id": "reaction_10453360", "reactome": "R-DME-549112", "name": "G3P is acylated to 1-acyl LPA by AGPAT6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_1500604", "species_76194" ], "modifiers": [ [ "species_10432535", "catalyst" ] ], "additional_components": [ "FBgn0031132" ] }, "reaction_10459662": { "compartment": "compartment_17906", "id": "reaction_10459662", "reactome": "R-DME-1482695", "name": "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_76114" ], "products": [ "species_76194", "species_1500580" ], "modifiers": [ [ "species_10432552", "catalyst" ] ], "additional_components": [ "FBgn0027579" ] }, "reaction_10460330": { "compartment": "compartment_984", "id": "reaction_10460330", "reactome": "R-DME-1602446", "name": "PA is hydrolyzed to 1-acyl LPA by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1602448" ], "products": [ "species_1602447", "species_1602366" ], "modifiers": [ [ "species_10460316", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10495095": { "compartment": "compartment_17906", "id": "reaction_10495095", "reactome": "R-DME-8954398", "name": "PLD6 dimer hydrolyses cardiolipin to PA and PG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189422", "species_8954419" ], "products": [ "species_8954401", "species_1500590" ], "modifiers": [ [ "species_10495077", "catalyst" ], [ "species_10495093", "catalyst" ] ], "additional_components": [ "Q9VKD7", "FBgn0261266", "Q9W3F7", "FBgn0030037" ] }, "reaction_10459655": { "compartment": "compartment_12045", "id": "reaction_10459655", "reactome": "R-DME-1482679", "name": "PA is hydrolysed to 1-acyl LPA by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426755" ], "products": [ "species_1500604", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10432547": { "compartment": "compartment_12045", "id": "reaction_10432547", "reactome": "R-DME-75885", "name": "1-acyl LPA is acylated to PA by AGPAT (LPAAT)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500604", "species_1500578" ], "products": [ "species_426755", "species_76194" ], "modifiers": [ [ "species_10432544", "catalyst" ] ], "additional_components": [ "Q0KHU5", "FBgn0052699", "Q9VRC1", "FBgn0031132", "Q9VYJ4", "FBgn0030421", "Q7KTI0", "FBgn0026718", "D5AEK7", "FBgn0036623", "Q9VV49", "FBgn0036622" ] }, "reaction_10432609": { "compartment": "compartment_70101", "id": "reaction_10432609", "reactome": "R-DME-75889", "name": "DHAP is converted to G3P by GPD1/GPD1L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_75970", "species_73473" ], "products": [ "species_76114", "species_29360" ], "modifiers": [ [ "species_10432606", "catalyst" ] ], "additional_components": [ "P13706", "FBgn0001128", "Q9W1U3", "FBgn0034825", "Q8IN06", "FBgn0263048" ] }, "reaction_10493857": { "compartment": "compartment_984", "id": "reaction_10493857", "reactome": "R-DME-8952251", "name": "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_2173763" ], "products": [ "species_8954142", "species_8952253" ], "modifiers": [ [ "species_10493854", "catalyst" ] ], "additional_components": [ "Q9I7L9", "FBgn0042175", "Q9Y168", "FBgn0051683" ] }, "reaction_10460319": { "compartment": "compartment_984", "id": "reaction_10460319", "reactome": "R-DME-1602374", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2[15]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_33625" ], "products": [ "species_1602419", "species_1602366" ], "modifiers": [ [ "species_10460316", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459660": { "compartment": "compartment_12045", "id": "reaction_10459660", "reactome": "R-DME-1482691", "name": "2-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498722" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10459669": { "compartment": "compartment_12045", "id": "reaction_10459669", "reactome": "R-DME-1482776", "name": "PS is hydrolyzed to 1-acyl LPS by PLA2G2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500646" ], "products": [ "species_1524021", "species_1498724" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10459620": { "compartment": "compartment_12045", "id": "reaction_10459620", "reactome": "R-DME-1482636", "name": "1-acyl LPS is acylated to PS by LPSAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498724" ], "products": [ "species_76194", "species_1500646" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10459704": { "compartment": "compartment_12045", "id": "reaction_10459704", "reactome": "R-DME-1482887", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[3]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10459652", "catalyst" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655" ] }, "reaction_10459623": { "compartment": "compartment_12045", "id": "reaction_10459623", "reactome": "R-DME-1482646", "name": "2-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1498729", "species_1500578" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10479047": { "compartment": "compartment_70101", "id": "reaction_10479047", "reactome": "R-DME-5694583", "name": "ABHD4 hydrolyses NAPE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5694568", "species_29356" ], "products": [ "species_5694580", "species_5694567" ], "modifiers": [ [ "species_10479044", "catalyst" ] ], "additional_components": [ "FBgn0033226" ] }, "reaction_10459702": { "compartment": "compartment_12045", "id": "reaction_10459702", "reactome": "R-DME-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1500581" ], "products": [ "species_1498738", "species_1524021" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10460323": { "compartment": "compartment_984", "id": "reaction_10460323", "reactome": "R-DME-1602398", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[16]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1602375", "species_109276" ], "products": [ "species_1602372", "species_1602366" ], "modifiers": [ [ "species_10460293", "catalyst" ], [ "species_10460311", "inhibitor" ] ], "additional_components": [ "species_74016", "Q8IML0", "FBgn0039655", "Q9W3I8", "FBgn0030013", "Q9VYG9", "FBgn0250862", "Q7JX94", "FBgn0050503", "Q9W4I0", "FBgn0029720", "Q6XPX3", "FBgn0033170", "Q9VUV6", "FBgn0036545", "O46197", "FBgn0015583", "Q9VPS3", "FBgn0031273", "Q6GV06", "FBgn0040097" ] }, "reaction_10459648": { "compartment": "compartment_12045", "id": "reaction_10459648", "reactome": "R-DME-1482667", "name": "1-acyl LPE is acylated to PE by LPEAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500578", "species_1498738" ], "products": [ "species_76194", "species_1500581" ], "modifiers": [ [ "species_10459617", "catalyst" ] ], "additional_components": [ "Q9VVX5", "FBgn0026630", "Q6NN55", "FBgn0033476" ] }, "reaction_10459787": { "compartment": "compartment_12045", "id": "reaction_10459787", "reactome": "R-DME-1483081", "name": "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_1524071" ], "products": [ "species_111294", "species_1524060" ], "modifiers": [ [ "species_10459784", "catalyst" ] ], "additional_components": [ "Q9W0D9", "FBgn0035231", "Q7K4C7", "FBgn0041342" ] }, "reaction_10443498": { "compartment": "compartment_70101", "id": "reaction_10443498", "reactome": "R-DME-264622", "name": "Cho is acetylated to AcCho by CHAT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_76183" ], "products": [ "species_264643", "species_76194" ], "modifiers": [ [ "species_10443495", "catalyst" ] ], "additional_components": [ "FBgn0000303" ] }, "reaction_10459817": { "compartment": "compartment_70101", "id": "reaction_10459817", "reactome": "R-DME-1483159", "name": "PCho is dephosphorylated to Cho by PHOSPHO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1524071" ], "products": [ "species_264618", "species_29372" ], "modifiers": [ [ "species_10459801", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VWF3", "FBgn0031045", "Q9VWF0", "FBgn0031048" ] }, "reaction_10491447": { "compartment": "compartment_12045", "id": "reaction_10491447", "reactome": "R-DME-8877153", "name": "STARD7 binds PC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426925", "species_10491443" ], "products": [ "species_10491445" ], "modifiers": [], "additional_components": [ "FBgn0032513", "Q9VJZ2", "FBgn0032513", "species_429802" ] }, "reaction_10479012": { "compartment": "compartment_876", "id": "reaction_10479012", "reactome": "R-DME-5694485", "name": "ABHD3 hydrolyses LPC(14:0) to 1AGPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694502" ], "products": [ "species_5694457", "species_1861754" ], "modifiers": [ [ "species_10479009", "catalyst" ] ], "additional_components": [ "FBgn0033382" ] }, "reaction_10459761": { "compartment": "compartment_70101", "id": "reaction_10459761", "reactome": "R-DME-1483004", "name": "Cho is phosphorylated to PCho by CHK dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618", "species_113592" ], "products": [ "species_29370", "species_1524071" ], "modifiers": [ [ "species_10459758", "catalyst" ] ], "additional_components": [ "Q8IMF4", "FBgn0032955" ] }, "reaction_10465406": { "compartment": "compartment_161320", "id": "reaction_10465406", "reactome": "R-DME-2213240", "name": "Reduction of disulphide bonds in MHC II antigens", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213221" ], "products": [ "species_2213225" ], "modifiers": [ [ "species_10465403", "catalyst" ] ], "additional_components": [ "Q9VCK1", "FBgn0039099", "Q95RA9", "FBgn0038149", "Q9VHA5", "FBgn0037721", "Q9VCK2", "FBgn0039098" ] }, "reaction_10465008": { "compartment": "compartment_161320", "id": "reaction_10465008", "reactome": "R-DME-2130706", "name": "MHC class II antigen processing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2213225" ], "products": [ "species_2213226" ], "modifiers": [ [ "species_10465005", "catalyst" ] ], "additional_components": [ "Q9VN93", "FBgn0260462", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q7K485", "FBgn0029093" ] }, "reaction_10431263": { "compartment": "compartment_70101", "id": "reaction_10431263", "reactome": "R-DME-73812", "name": "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111354", "species_113592", "species_29472" ], "products": [ "species_29372", "species_29404", "species_29370", "species_111369" ], "modifiers": [ [ "species_10431260", "catalyst" ] ], "additional_components": [ "FBgn0000052" ] }, "reaction_10434110": { "compartment": "compartment_70101", "id": "reaction_10434110", "reactome": "R-DME-111289", "name": "Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434106" ], "products": [ "species_10431276" ], "modifiers": [ [ "species_73566", "catalyst" ] ], "additional_components": [ "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793", "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793" ] }, "reaction_10431198": { "compartment": "compartment_70101", "id": "reaction_10431198", "reactome": "R-DME-73792", "name": "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_111584", "species_29472" ], "products": [ "species_111294", "species_29404", "species_113578", "species_76577" ], "modifiers": [ [ "species_10431195", "catalyst" ] ], "additional_components": [ "FBgn0000239" ] }, "reaction_10434142": { "compartment": "compartment_70101", "id": "reaction_10434142", "reactome": "R-DME-111524", "name": "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_29448", "species_29602" ], "products": [ "species_29372", "species_29420", "species_35141" ], "modifiers": [ [ "species_10434139", "catalyst" ], [ "species_29420", "inhibitor" ], [ "species_30014", "inhibitor" ], [ "species_35141", "inhibitor" ], [ "species_113578", "inhibitor" ] ], "additional_components": [ "species_29926", "Q9Y0Y2", "FBgn0027493" ] }, "reaction_10434108": { "compartment": "compartment_70101", "id": "reaction_10434108", "reactome": "R-DME-111285", "name": "Formation of phosphoribosyl pyrophosphate amidotransferase tetramer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431276" ], "products": [ "species_10434106" ], "modifiers": [ [ "species_29602", "catalyst" ], [ "species_113578", "catalyst" ], [ "species_76577", "catalyst" ] ], "additional_components": [ "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793", "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793" ] }, "reaction_10431224": { "compartment": "compartment_70101", "id": "reaction_10431224", "reactome": "R-DME-73798", "name": "AICAR + 10-Formyl-THF => FAICAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_419151", "species_111409" ], "products": [ "species_111355", "species_111427" ], "modifiers": [ [ "species_10431218", "catalyst" ] ], "additional_components": [ "Q9VC18", "FBgn0039241" ] }, "reaction_10431255": { "compartment": "compartment_70101", "id": "reaction_10431255", "reactome": "R-DME-73810", "name": "FGAM + ATP => AIR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_111369" ], "products": [ "species_29372", "species_111370", "species_29370" ], "modifiers": [ [ "species_10431252", "catalyst" ] ], "additional_components": [ "FBgn0000053" ] }, "reaction_10498472": { "compartment": "compartment_70101", "id": "reaction_10498472", "reactome": "R-DME-9678749", "name": "IMPDH tetramers binds IMPDH inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678719", "species_10431205" ], "products": [ "species_10431208" ], "modifiers": [], "additional_components": [ "Q07152", "FBgn0003204", "Q07152", "FBgn0003204" ] }, "reaction_10431221": { "compartment": "compartment_70101", "id": "reaction_10431221", "reactome": "R-DME-73797", "name": "FAICAR => IMP + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111427" ], "products": [ "species_29356", "species_29602" ], "modifiers": [ [ "species_10431218", "catalyst" ] ], "additional_components": [ "Q9VC18", "FBgn0039241" ] }, "reaction_10431281": { "compartment": "compartment_70101", "id": "reaction_10431281", "reactome": "R-DME-73828", "name": "adenylosuccinate => adenosine 5'-monophosphate + fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_35141" ], "products": [ "species_29586", "species_76577" ], "modifiers": [ [ "species_10431231", "catalyst" ] ], "additional_components": [ "Q9VEP6", "FBgn0038467" ] }, "reaction_10431279": { "compartment": "compartment_70101", "id": "reaction_10431279", "reactome": "R-DME-73815", "name": "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_29356", "species_29472" ], "products": [ "species_111294", "species_111292", "species_29404" ], "modifiers": [ [ "species_10431276", "catalyst" ] ], "additional_components": [ "Q27601", "FBgn0004901", "CHEBI:17909", "species_111793" ] }, "reaction_10431247": { "compartment": "compartment_70101", "id": "reaction_10431247", "reactome": "R-DME-73806", "name": "AIR + CO2 => CAIR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111370", "species_113528" ], "products": [ "species_111395" ], "modifiers": [ [ "species_10431241", "catalyst" ] ], "additional_components": [ "Q9I7S8", "FBgn0020513" ] }, "reaction_10431244": { "compartment": "compartment_70101", "id": "reaction_10431244", "reactome": "R-DME-73805", "name": "CAIR + Aspartate + ATP => SAICAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29448", "species_111395" ], "products": [ "species_29372", "species_29370", "species_111399" ], "modifiers": [ [ "species_10431241", "catalyst" ] ], "additional_components": [ "Q9I7S8", "FBgn0020513" ] }, "reaction_10431210": { "compartment": "compartment_70101", "id": "reaction_10431210", "reactome": "R-DME-73794", "name": "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29602", "species_29360" ], "products": [ "species_70106", "species_111584", "species_73473" ], "modifiers": [ [ "species_10431205", "catalyst" ], [ "species_10431208", "inhibitor" ], [ "species_111584", "inhibitor" ] ], "additional_components": [ "Q07152", "FBgn0003204", "Q07152", "FBgn0003204" ] }, "reaction_10431269": { "compartment": "compartment_70101", "id": "reaction_10431269", "reactome": "R-DME-73814", "name": "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111292", "species_113592", "species_29424" ], "products": [ "species_29372", "species_111338", "species_29370" ], "modifiers": [ [ "species_10431252", "catalyst" ] ], "additional_components": [ "FBgn0000053" ] }, "reaction_10431266": { "compartment": "compartment_70101", "id": "reaction_10431266", "reactome": "R-DME-73813", "name": "GAR + 10-Formyl-THF => FGAR + THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111338", "species_419151" ], "products": [ "species_111354", "species_111355" ], "modifiers": [ [ "species_10431252", "catalyst" ] ], "additional_components": [ "FBgn0000053" ] }, "reaction_10431234": { "compartment": "compartment_70101", "id": "reaction_10431234", "reactome": "R-DME-73800", "name": "SAICAR => AICAR + Fumarate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111399" ], "products": [ "species_29586", "species_111409" ], "modifiers": [ [ "species_10431231", "catalyst" ] ], "additional_components": [ "Q9VEP6", "FBgn0038467" ] }, "reaction_10498768": { "compartment": "compartment_70101", "id": "reaction_10498768", "reactome": "R-DME-9708536", "name": "HMOX1 translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497417" ], "products": [ "species_10498766" ], "modifiers": [], "additional_components": [ "FBgn0037933", "FBgn0037933" ] }, "reaction_10498774": { "compartment": "compartment_70101", "id": "reaction_10498774", "reactome": "R-DME-9708558", "name": "HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439555" ], "products": [ "species_10498772" ], "modifiers": [], "additional_components": [ "Q9VGJ9", "FBgn0037933", "Q9VGJ9", "FBgn0037933" ] }, "reaction_10498760": { "compartment": "compartment_12045", "id": "reaction_10498760", "reactome": "R-DME-9708457", "name": "HM13 cleaves HMOX1 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439555" ], "products": [ "species_10497417" ], "modifiers": [ [ "species_10498757", "catalyst" ] ], "additional_components": [ "Q9VGJ9", "FBgn0037933", "FBgn0037933", "FBgn0031260" ] }, "reaction_10498762": { "compartment": "compartment_70101", "id": "reaction_10498762", "reactome": "R-DME-9708466", "name": "BACH1 translocates from the nucleoplasm to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498736" ], "products": [ "species_10498744" ], "modifiers": [ [ "species_3785707", "catalyst" ] ], "additional_components": [ "FBgn0030417", "FBgn0030417" ] }, "reaction_10491908": { "compartment": "compartment_70101", "id": "reaction_10491908", "reactome": "R-DME-8932327", "name": "NFE2L2 binds KEAP1:CUL3:RBX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491902", "species_10491904" ], "products": [ "species_10491906" ], "modifiers": [], "additional_components": [ "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975" ] }, "reaction_10498789": { "compartment": "compartment_70101", "id": "reaction_10498789", "reactome": "R-DME-9712274", "name": "NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9714134", "species_10491906" ], "products": [ "species_10498787" ], "modifiers": [], "additional_components": [ "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975" ] }, "reaction_10491912": { "compartment": "compartment_70101", "id": "reaction_10491912", "reactome": "R-DME-8932334", "name": "KEAP1:CUL3:RBX1:NFE2L2 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491906", "species_10491904" ], "products": [ "species_10491902", "species_10491910" ], "modifiers": [], "additional_components": [ "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268" ] }, "reaction_10491900": { "compartment": "compartment_70101", "id": "reaction_10491900", "reactome": "R-DME-8932309", "name": "NFE2L2 translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491892" ], "products": [ "species_10491898" ], "modifiers": [], "additional_components": [] }, "reaction_10491917": { "compartment": "compartment_70101", "id": "reaction_10491917", "reactome": "R-DME-8932351", "name": "KEAP1 facilitates ubiquitination of NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426987", "species_10491906" ], "products": [ "species_10491914", "species_10491904" ], "modifiers": [ [ "species_10491906", "catalyst" ], [ "species_1250243", "inhibitor" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P20482", "FBgn0262975", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "Q7KSF5", "FBgn0038475", "Q9W5E1", "Roc1a", "Q8IP45", "FBgn0261268", "P20482", "FBgn0262975" ] }, "reaction_10491919": { "compartment": "compartment_70101", "id": "reaction_10491919", "reactome": "R-DME-8932355", "name": "26S proteasome degrades Ub-NFE2L2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491914" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P20482", "FBgn0262975", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10439548": { "compartment": "compartment_70101", "id": "reaction_10439548", "reactome": "R-DME-189384", "name": "BLVRA:Zn2+, BLVRB reduce BV to BIL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189396", "species_29364" ], "products": [ "species_189386", "species_29366" ], "modifiers": [ [ "species_10439545", "catalyst" ] ], "additional_components": [ "FBgn0037749" ] }, "reaction_10439562": { "compartment": "compartment_70101", "id": "reaction_10439562", "reactome": "R-DME-189398", "name": "HMOX1 dimer, HMOX2 cleave heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_29364", "species_71185" ], "products": [ "species_29356", "species_189385", "species_71067", "species_189396", "species_29366" ], "modifiers": [ [ "species_10439559", "catalyst" ] ], "additional_components": [ "Q9VGJ9", "FBgn0037933" ] }, "reaction_10436293": { "compartment": "compartment_70616", "id": "reaction_10436293", "reactome": "R-DME-163214", "name": "Electron transfer from reduced cytochrome c to molecular oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_10436148", "species_113529" ], "products": [ "species_10436150", "species_163953", "species_113521" ], "modifiers": [ [ "species_10436237", "catalyst" ], [ "species_10436243", "catalyst" ], [ "species_10436265", "catalyst" ], [ "species_10436289", "catalyst" ], [ "species_10436291", "inhibitor" ] ], "additional_components": [ "CHEBI:38573", "P84029", "FBgn0284248", "CHEBI:38574", "P84029", "FBgn0284248", "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "FBgn0260222", "Q9VF98", "FBgn0011476", "Q9VMQ6", "FBgn0051648", "Q9VST8", "FBgn0035960", "Q9VG00", "FBgn0002354", "Q9VL11", "FBgn0032205", "Q9VJ86", "FBgn0284256", "Q9U4F3", "FBgn0029117", "Q9VMX4", "FBgn0262467", "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "species_9709326" ] }, "reaction_10498783": { "compartment": "compartment_70616", "id": "reaction_10498783", "reactome": "R-DME-9709406", "name": "CO binds to Cytochrome c oxidase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9709326", "species_10436237" ], "products": [ "species_10436291" ], "modifiers": [], "additional_components": [ "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "P00399", "FBgn0013674", "Q9VP19", "FBgn0263911", "Q9VMB9", "FBgn0031830", "Q94514", "FBgn0019624", "Q8T4H8", "FBgn0033020", "Q9VIQ8", "FBgn0032833", "Q9VWD1", "FBgn0031066", "Q8SYJ2", "FBgn0052230", "Q9W1N3", "FBgn0034877", "P00417", "FBgn0013676", "P00408", "FBgn0013675", "CHEBI:28694", "Q9VHR9", "FBgn0037579", "Q6IHY5", "FBgn0085201", "Q9VHS2", "FBgn0040529", "Q7JW00", "FBgn0040773", "species_9709326" ] }, "reaction_10498367": { "compartment": "compartment_70101", "id": "reaction_10498367", "reactome": "R-DME-9661405", "name": "ABCC1 transports BIL from cytosol to extracellular region (blood)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386" ], "products": [ "species_9661418" ], "modifiers": [ [ "species_10443830", "catalyst" ] ], "additional_components": [ "FBgn0032456" ] }, "reaction_10445949": { "compartment": "compartment_12045", "id": "reaction_10445949", "reactome": "R-DME-381109", "name": "IRE1 binds IRE1 forming dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445937" ], "products": [ "species_10445939" ], "modifiers": [], "additional_components": [ "FBgn0261984", "A8JR46", "FBgn0261984" ] }, "reaction_10445947": { "compartment": "compartment_12045", "id": "reaction_10445947", "reactome": "R-DME-381091", "name": "IRE1 dimer autophosphorylates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445939", "species_113592" ], "products": [ "species_29370", "species_10445944" ], "modifiers": [ [ "species_10445939", "catalyst" ] ], "additional_components": [ "A8JR46", "FBgn0261984", "A8JR46", "FBgn0261984", "A8JR46", "FBgn0261984" ] }, "reaction_10498384": { "compartment": "compartment_70101", "id": "reaction_10498384", "reactome": "R-DME-9663492", "name": "BIL dissociates from GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498382" ], "products": [ "species_189386", "species_10471582" ], "modifiers": [], "additional_components": [ "Q8INK3", "FBgn0037913", "species_9661418", "FBgn0037913" ] }, "reaction_10498386": { "compartment": "compartment_70101", "id": "reaction_10498386", "reactome": "R-DME-9663511", "name": "BIL binds GSTA1, FABP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189386", "species_10471582" ], "products": [ "species_10498382" ], "modifiers": [], "additional_components": [ "FBgn0037913", "Q8INK3", "FBgn0037913", "species_9661418" ] }, "reaction_10498370": { "compartment": "compartment_70101", "id": "reaction_10498370", "reactome": "R-DME-9661417", "name": "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_5679042" ], "products": [ "species_29372", "species_5679034", "species_29370" ], "modifiers": [ [ "species_10455124", "catalyst" ] ], "additional_components": [ "CHEBI:18392", "CHEBI:16427", "CHEBI:16427", "CHEBI:18392", "P45843", "FBgn0003515", "P12428", "FBgn0000241", "Q0KI14", "FBgn0051121" ] }, "reaction_10498375": { "compartment": "compartment_876", "id": "reaction_10498375", "reactome": "R-DME-9661723", "name": "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10498372", "catalyst" ] ], "additional_components": [ "FBgn0032123" ] }, "reaction_10498380": { "compartment": "compartment_70101", "id": "reaction_10498380", "reactome": "R-DME-9661799", "name": "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10498377", "catalyst" ] ], "additional_components": [ "FBgn0032123" ] }, "reaction_10498365": { "compartment": "compartment_70101", "id": "reaction_10498365", "reactome": "R-DME-9661397", "name": "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9661418" ], "products": [ "species_189386" ], "modifiers": [ [ "species_10454191", "catalyst" ] ], "additional_components": [ "FBgn0032123" ] }, "reaction_10486017": { "compartment": "compartment_7660", "id": "reaction_10486017", "reactome": "R-DME-6804441", "name": "RNF34 or RFFL ubiquitinates phosphorylated TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10427430" ], "products": [ "species_10486010" ], "modifiers": [ [ "species_10486012", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8IMZ4", "FBgn0039044", "FBgn0033783" ] }, "reaction_10481097": { "compartment": "compartment_70101", "id": "reaction_10481097", "reactome": "R-DME-6793685", "name": "Ubiquitinated TP53 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467609" ], "products": [ "species_10481095" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10467619": { "compartment": "compartment_7660", "id": "reaction_10467619", "reactome": "R-DME-3215310", "name": "USP7 deubiquitinates TP53 and counteracts MDM2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10467609" ], "products": [ "species_10427430", "species_10467611" ], "modifiers": [ [ "species_10467616", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8IMZ4", "FBgn0039044", "FBgn0030366" ] }, "reaction_10495584": { "compartment": "compartment_70101", "id": "reaction_10495584", "reactome": "R-DME-8981621", "name": "Neuroglobin:oxygen dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495580" ], "products": [ "species_10495578", "species_29368" ], "modifiers": [], "additional_components": [ "species_113535", "species_71185", "Q9VF15", "FBgn0027657", "species_71185", "Q9VF15", "FBgn0027657" ] }, "reaction_10495582": { "compartment": "compartment_70101", "id": "reaction_10495582", "reactome": "R-DME-8981610", "name": "Neuroglobin binds oxygen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495578", "species_29368" ], "products": [ "species_10495580" ], "modifiers": [], "additional_components": [ "species_71185", "Q9VF15", "FBgn0027657", "species_113535", "species_71185", "Q9VF15", "FBgn0027657" ] }, "reaction_10471496": { "compartment": "compartment_70101", "id": "reaction_10471496", "reactome": "R-DME-5263616", "name": "MeSeO2H is reduced to MeSeOH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357694", "species_70106", "species_29364" ], "products": [ "species_5357663", "species_29356", "species_29366" ], "modifiers": [ [ "species_10431010", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VNT5", "FBgn0037170", "P91938", "FBgn0020653" ] }, "reaction_10471493": { "compartment": "compartment_70101", "id": "reaction_10471493", "reactome": "R-DME-5263614", "name": "MeSeOH is reduced to MeSeH by TXNRD1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357663", "species_70106", "species_29364" ], "products": [ "species_29356", "species_29366", "species_5357669" ], "modifiers": [ [ "species_10431010", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VNT5", "FBgn0037170", "P91938", "FBgn0020653" ] }, "reaction_10464075": { "compartment": "compartment_70101", "id": "reaction_10464075", "reactome": "R-DME-2025890", "name": "Calcineurin binds NFATC1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434387", "species_10464021", "species_10464038", "species_74016" ], "products": [ "species_10464073" ], "modifiers": [], "additional_components": [ "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "FBgn0030505", "species_1562550", "species_1222611", "Q9VXF1", "FBgn0267912", "Q27889", "FBgn0011826", "P48456", "FBgn0010015", "species_74016", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q24214", "FBgn0015614", "A8JUV3", "FBgn0030505" ] }, "reaction_10498551": { "compartment": "compartment_70101", "id": "reaction_10498551", "reactome": "R-DME-9690461", "name": "FKBP1A binds tacrolimus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9678991", "species_10437068" ], "products": [ "species_10498549" ], "modifiers": [], "additional_components": [ "FBgn0013954", "P48375", "FBgn0013954" ] }, "reaction_10495732": { "compartment": "compartment_70101", "id": "reaction_10495732", "reactome": "R-DME-8983373", "name": "p-Y-STAT3 binds p-STAT5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495726", "species_10495728" ], "products": [ "species_10495730" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10495748": { "compartment": "compartment_70101", "id": "reaction_10495748", "reactome": "R-DME-8983379", "name": "p-Y-STAT3:p-STAT5 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495730" ], "products": [ "species_10495746" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495777": { "compartment": "compartment_70101", "id": "reaction_10495777", "reactome": "R-DME-8985981", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495769" ], "products": [ "species_10495775" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495763": { "compartment": "compartment_70101", "id": "reaction_10495763", "reactome": "R-DME-8985943", "name": "p-Y701-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495759" ], "products": [ "species_10495761" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10495767": { "compartment": "compartment_70101", "id": "reaction_10495767", "reactome": "R-DME-8985950", "name": "p-Y649-STAT5A, p-STAT5B dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495726" ], "products": [ "species_10495765" ], "modifiers": [], "additional_components": [] }, "reaction_10495771": { "compartment": "compartment_70101", "id": "reaction_10495771", "reactome": "R-DME-8985966", "name": "p-Y701-STAT1 binds p-Y705-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495759", "species_10495728" ], "products": [ "species_10495769" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10458684": { "compartment": "compartment_876", "id": "reaction_10458684", "reactome": "R-DME-1296043", "name": "Activation of HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458681", "catalyst" ] ], "additional_components": [ "species_30389", "A1Z9N7", "FBgn0263397" ] }, "reaction_10458851": { "compartment": "compartment_876", "id": "reaction_10458851", "reactome": "R-DME-1297444", "name": "Binding of cAMP to HCN channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458679", "species_30389" ], "products": [ "species_10458681" ], "modifiers": [], "additional_components": [ "A1Z9N7", "FBgn0263397", "species_30389", "A1Z9N7", "FBgn0263397" ] }, "reaction_10476866": { "compartment": "compartment_70101", "id": "reaction_10476866", "reactome": "R-DME-5688797", "name": "ATXN3 family cleave Ub chains", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10437507" ], "products": [ "species_10437505", "species_10437507" ], "modifiers": [ [ "species_10476863", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W422", "FBgn0029853" ] }, "reaction_10477104": { "compartment": "compartment_70101", "id": "reaction_10477104", "reactome": "R-DME-5689111", "name": "PARK2 autoubiquitinates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456711", "species_10477101" ], "products": [ "species_10476869" ], "modifiers": [ [ "species_10456711", "catalyst" ] ], "additional_components": [ "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0041100", "FBgn0041100" ] }, "reaction_10459500": { "compartment": "compartment_70101", "id": "reaction_10459500", "reactome": "R-DME-1475026", "name": "Carbonic anhydrase hydrates carbon dioxide (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113528" ], "products": [ "species_70106", "species_111627" ], "modifiers": [ [ "species_10459493", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10459498": { "compartment": "compartment_876", "id": "reaction_10459498", "reactome": "R-DME-1475025", "name": "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10459454", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9V9Y6", "FBgn0040629", "Q8IMV4", "FBgn0039235", "Q4V4S9", "FBgn0038956", "Q9VTU8", "FBgn0027843", "Q9VH26", "FBgn0037788", "Q9VB76", "FBgn0039486", "Q9V9Y8", "FBgn0039838" ] }, "reaction_10459496": { "compartment": "compartment_70101", "id": "reaction_10459496", "reactome": "R-DME-1475022", "name": "Carbonic anhydrase dehydrates bicarbonate (cytosol)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_111627" ], "products": [ "species_29356", "species_113528" ], "modifiers": [ [ "species_10459493", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10459523": { "compartment": "compartment_5460", "id": "reaction_10459523", "reactome": "R-DME-1475032", "name": "Carbonic anhydrase hydrates carbon dioxide (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113521", "species_29376" ], "products": [ "species_29896", "species_113529" ], "modifiers": [ [ "species_10459518", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10458226": { "compartment": "compartment_984", "id": "reaction_10458226", "reactome": "R-DME-1237045", "name": "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1237009" ], "products": [ "species_351626", "species_425425" ], "modifiers": [ [ "species_10458223", "catalyst" ] ], "additional_components": [ "Q4V4S9", "FBgn0038956", "Q9V9Y8", "FBgn0039838", "Q9VTU8", "FBgn0027843", "Q9V9Y6", "FBgn0040629", "Q9VH26", "FBgn0037788", "Q8IMV4", "FBgn0039235", "Q9VB76", "FBgn0039486", "species_1562550" ] }, "reaction_10459457": { "compartment": "compartment_876", "id": "reaction_10459457", "reactome": "R-DME-1475017", "name": "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10459454", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9V9Y6", "FBgn0040629", "Q8IMV4", "FBgn0039235", "Q4V4S9", "FBgn0038956", "Q9VTU8", "FBgn0027843", "Q9VH26", "FBgn0037788", "Q9VB76", "FBgn0039486", "Q9V9Y8", "FBgn0039838" ] }, "reaction_10459521": { "compartment": "compartment_5460", "id": "reaction_10459521", "reactome": "R-DME-1475028", "name": "Carbonic anhydrase dehydrates bicarbonate (mitochondria)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29896", "species_113529" ], "products": [ "species_113521", "species_29376" ], "modifiers": [ [ "species_10459518", "catalyst" ] ], "additional_components": [ "Q9W3C8", "FBgn0030056", "Q9V396", "FBgn0027844", "species_1562550" ] }, "reaction_10458241": { "compartment": "compartment_984", "id": "reaction_10458241", "reactome": "R-DME-1237081", "name": "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_425425" ], "products": [ "species_109276", "species_1237009" ], "modifiers": [ [ "species_10458223", "catalyst" ] ], "additional_components": [ "Q4V4S9", "FBgn0038956", "Q9V9Y8", "FBgn0039838", "Q9VTU8", "FBgn0027843", "Q9V9Y6", "FBgn0040629", "Q9VH26", "FBgn0037788", "Q8IMV4", "FBgn0039235", "Q9VB76", "FBgn0039486", "species_1562550" ] }, "reaction_10444363": { "compartment": "compartment_876", "id": "reaction_10444363", "reactome": "R-DME-372529", "name": "Release of acetylcholine at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444322" ], "products": [ "species_10443025", "species_10442919", "species_10444360", "species_10443003", "species_10443019", "species_10442973", "species_10443023", "species_372533" ], "modifiers": [ [ "species_10444322", "catalyst" ] ], "additional_components": [ "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0004574", "FBgn0270928", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343" ] }, "reaction_10444325": { "compartment": "compartment_70101", "id": "reaction_10444325", "reactome": "R-DME-372505", "name": "Acetylcholine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10442919", "species_10442968", "species_10443003", "species_10442973", "species_10443487" ], "products": [ "species_10444322" ], "modifiers": [ [ "species_10443487", "catalyst" ] ], "additional_components": [ "FBgn0013343", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660" ] }, "reaction_10443490": { "compartment": "compartment_70101", "id": "reaction_10443490", "reactome": "R-DME-264615", "name": "Loading of acetylcholine in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_372511", "species_264643", "species_10443485" ], "products": [ "species_70106", "species_10443487" ], "modifiers": [ [ "species_10443479", "catalyst" ] ], "additional_components": [ "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "species_372533", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "O17444", "FBgn0270928", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "FBgn0270928" ] }, "reaction_10427772": { "compartment": "compartment_70101", "id": "reaction_10427772", "reactome": "R-DME-69600", "name": "Proteolytic degradation of ubiquitinated-Cdc25A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427770" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10427800": { "compartment": "compartment_7660", "id": "reaction_10427800", "reactome": "R-DME-69608", "name": "Phosphorylation of Cdc25A at Ser-123 by Chk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427741" ], "products": [ "species_113582", "species_10427778" ], "modifiers": [ [ "species_10427797", "catalyst" ] ], "additional_components": [ "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "P20483", "FBgn0003525", "Q03019", "FBgn0002673", "FBgn0019686" ] }, "reaction_10498677": { "compartment": "compartment_70101", "id": "reaction_10498677", "reactome": "R-DME-9698844", "name": "MLKL binds HSP90:CDC37", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471010", "species_10462118", "species_10462120" ], "products": [ "species_10498675" ], "modifiers": [], "additional_components": [ "Q24276", "FBgn0011573", "P02828", "FBgn0001233", "P02828", "FBgn0001233", "Q24276", "FBgn0011573", "P11346", "Raf" ] }, "reaction_10476089": { "compartment": "compartment_70101", "id": "reaction_10476089", "reactome": "R-DME-5675470", "name": "BIRC2/3 (cIAP1/2) is autoubiquitinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454480", "species_10471711" ], "products": [ "species_10476086" ], "modifiers": [ [ "species_10471711", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1", "Q24307", "Diap2", "Q24306", "Diap1" ] }, "reaction_10440446": { "compartment": "compartment_876", "id": "reaction_10440446", "reactome": "R-DME-194187", "name": "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440408", "species_192483", "species_74113" ], "products": [ "species_83910", "species_10440410" ], "modifiers": [ [ "species_10440422", "catalyst" ], [ "species_10440444", "catalyst" ] ], "additional_components": [ "FBgn0037913", "CHEBI:17687", "CHEBI:28865", "CHEBI:16755", "CHEBI:36274", "species_193473", "CHEBI:9407", "Q8INK3", "FBgn0037913", "species_193473", "CHEBI:17687", "CHEBI:36274", "CHEBI:16525", "CHEBI:16755", "CHEBI:28865", "Q9VXF5", "FBgn0030756", "Q9VXV4", "FBgn0030638", "P20153", "FBgn0003964", "M9ND53", "FBgn0041092", "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546" ] }, "reaction_10471675": { "compartment": "compartment_7660", "id": "reaction_10471675", "reactome": "R-DME-5340251", "name": "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440435", "species_10440440", "species_10440442", "species_10440428" ], "products": [ "species_10440444" ], "modifiers": [], "additional_components": [ "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546", "FBgn0041092", "FBgn0041092", "FBgn0003964", "P20153", "FBgn0003964", "M9ND53", "FBgn0041092", "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546" ] }, "reaction_10471673": { "compartment": "compartment_7660", "id": "reaction_10471673", "reactome": "R-DME-5340195", "name": "NR1H4 binds DCA, CDCA, LCHA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10440433", "species_5340249" ], "products": [ "species_10440435" ], "modifiers": [], "additional_components": [ "FBgn0000546", "species_176655", "CHEBI:16755", "CHEBI:28834", "species_176655", "CHEBI:16755", "CHEBI:28834", "P34021", "FBgn0000546" ] }, "reaction_10435765": { "compartment": "compartment_70101", "id": "reaction_10435765", "reactome": "R-DME-159425", "name": "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_194096" ], "products": [ "species_111294", "species_29356", "species_194073", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "species_193473", "CHEBI:16755", "CHEBI:15519", "CHEBI:28701", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10458872": { "compartment": "compartment_876", "id": "reaction_10458872", "reactome": "R-DME-1299318", "name": "Activation of TASK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458869", "catalyst" ] ], "additional_components": [ "Q9VHE0", "FBgn0037690", "Q9VFS9", "FBgn0038165" ] }, "reaction_10491685": { "compartment": "compartment_12045", "id": "reaction_10491685", "reactome": "R-DME-8877998", "name": "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491672" ], "products": [ "species_29420", "species_10491676", "species_10491105" ], "modifiers": [ [ "species_10491682", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9W4A0", "FBgn0015794", "species_29420", "Q9W4A0", "FBgn0015794", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935" ] }, "reaction_10491494": { "compartment": "compartment_17938", "id": "reaction_10491494", "reactome": "R-DME-8877451", "name": "MON1:CCZ1 exchanges GTP for GDP on RAB7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491471", "species_29438" ], "products": [ "species_29420", "species_10491477", "species_10491105" ], "modifiers": [ [ "species_10491491", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "O76742", "FBgn0015795", "species_29420", "O76742", "FBgn0015795", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VZL5", "FBgn0035470", "Q9VR38", "FBgn0031640" ] }, "reaction_10491114": { "compartment": "compartment_216813", "id": "reaction_10491114", "reactome": "R-DME-8875318", "name": "RAB3 GEFs exchange GTP for GDP on RAB3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491107" ], "products": [ "species_29420", "species_10491111", "species_10491105" ], "modifiers": [ [ "species_10474299", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29420", "P25228", "FBgn0005586", "P25228", "FBgn0005586", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0030613" ] }, "reaction_10491402": { "compartment": "compartment_70101", "id": "reaction_10491402", "reactome": "R-DME-8876616", "name": "DENND6A,B exchange GTP for GDP on RAB14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491388" ], "products": [ "species_29420", "species_10491105", "species_10491392" ], "modifiers": [ [ "species_10491397", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q86BK8", "FBgn0015791", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29438", "Q86BK8", "FBgn0015791", "FBgn0029756" ] }, "reaction_10491435": { "compartment": "compartment_171062", "id": "reaction_10491435", "reactome": "R-DME-8876837", "name": "RAB21 GEFs exchange GTP for GDP on RAB21", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491424" ], "products": [ "species_29420", "species_10491428", "species_10491105" ], "modifiers": [ [ "species_10491430", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q7PLE9", "FBgn0039966", "species_29420", "Q7PLE9", "FBgn0039966", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0025802" ] }, "reaction_10491467": { "compartment": "compartment_5668575", "id": "reaction_10491467", "reactome": "R-DME-8877308", "name": "MADD exchanges GTP for GDP on RAB27", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491455", "species_29438" ], "products": [ "species_29420", "species_10491465", "species_10491105" ], "modifiers": [ [ "species_10474299", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "O76901", "FBgn0025382", "species_29420", "O76901", "FBgn0025382", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0030613" ] }, "reaction_10491217": { "compartment": "compartment_437051", "id": "reaction_10491217", "reactome": "R-DME-8876188", "name": "DENND4s exchange GTP for GDP on RAB10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491201" ], "products": [ "species_29420", "species_10491205", "species_10491105" ], "modifiers": [ [ "species_10491210", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "O15971", "FBgn0015789", "species_29420", "O15971", "FBgn0015789", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0025864" ] }, "reaction_10491569": { "compartment": "compartment_262783", "id": "reaction_10491569", "reactome": "R-DME-8877612", "name": "DENND1s exchange GTP for GDP on RAB35", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491547" ], "products": [ "species_10491551", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491566", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9W5X0", "FBgn0031090", "species_29420", "Q9W5X0", "FBgn0031090", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "A1Z7Q5", "FBgn0027561", "P92177", "14-3-3epsilon" ] }, "reaction_10491634": { "compartment": "compartment_20699", "id": "reaction_10491634", "reactome": "R-DME-8877813", "name": "DENND5A,B exchange GTP for GDP on RAB39", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491618" ], "products": [ "species_29420", "species_10491624", "species_10491105" ], "modifiers": [ [ "species_10491629", "catalyst" ] ], "additional_components": [ "Q9W3Q0", "FBgn0029959", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9W3Q0", "FBgn0029959", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "FBgn0035229" ] }, "reaction_10491155": { "compartment": "compartment_171062", "id": "reaction_10491155", "reactome": "R-DME-8875320", "name": "RAB5 GEFs exchange GTP for GDP on RAB5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491118", "species_29438" ], "products": [ "species_29420", "species_10491126", "species_10491105" ], "modifiers": [ [ "species_10491152", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9V3I2", "FBgn0014010", "species_29420", "Q9V3I2", "FBgn0014010", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VNZ8", "FBgn0037116", "Q8MQW8", "FBgn0085443", "Q9W0H9", "FBgn0262937", "Q9VZ08", "FBgn0030286" ] }, "reaction_10491318": { "compartment": "compartment_262783", "id": "reaction_10491318", "reactome": "R-DME-8876454", "name": "DENND3 exchanges GTP for GDP on RAB12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491291" ], "products": [ "species_29420", "species_10491105", "species_10491313" ], "modifiers": [ [ "species_10491315", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q8IRK9", "FBgn0067052", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q9VC31", "FBgn0051118", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "Q9VQG6", "FBgn0031460", "Q8IRK8", "FBgn0052673", "Q9VZ47", "FBgn0052671", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29438", "Q8IRK8", "FBgn0052673", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "Q9VQG6", "FBgn0031460", "Q9VZ47", "FBgn0052671", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "Q9W3D3", "FBgn0025864" ] }, "reaction_10491543": { "compartment": "compartment_13946", "id": "reaction_10491543", "reactome": "R-DME-8877475", "name": "TRAPPC complexes exchange GTP for GDP on RAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491502", "species_29438" ], "products": [ "species_10491516", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491540", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29420", "O18332", "FBgn0285937", "O18332", "FBgn0285937", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q9VLI9", "FBgn0260861", "Q8IRE3", "FBgn0286567", "Q9VSY8", "FBgn0260859", "Q9VPB6", "FBgn0037022", "A1Z8I0", "FBgn0033605", "Q95TN1", "FBgn0032204", "Q9VUZ1", "FBgn0266724", "Q9VF82", "FBgn0266722", "Q9VW22", "FBgn0260655", "Q9VFB7", "FBgn0038303", "Q9VIL0", "FBgn0261787", "Q9VA95", "FBgn0260860", "Q7K2Q8", "FBgn0266723" ] }, "reaction_10491287": { "compartment": "compartment_70101", "id": "reaction_10491287", "reactome": "R-DME-8876446", "name": "p-ULK1 phosphorylates DENND3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10491280" ], "products": [ "species_29370", "species_10491284" ], "modifiers": [ [ "species_10475687", "catalyst" ] ], "additional_components": [ "FBgn0025864", "FBgn0025864", "FBgn0260945" ] }, "reaction_10491384": { "compartment": "compartment_204883", "id": "reaction_10491384", "reactome": "R-DME-8876615", "name": "RAB13 GEFs exchange GTP for GDP on RAB13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491352" ], "products": [ "species_10491374", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491381", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "species_29420", "Q9VQG6", "FBgn0031460", "O18338", "FBgn0262518", "Q9VZ47", "FBgn0052671", "Q8IR98", "FBgn0052670", "Q9W2S9", "FBgn0030221", "Q8IRK8", "FBgn0052673", "Q9W2V3", "FBgn0030200", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "Q9VQG6", "FBgn0031460", "Q9VZ47", "FBgn0052671", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "Q8IRK8", "FBgn0052673", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868" ] }, "reaction_10491960": { "compartment": "compartment_70101", "id": "reaction_10491960", "reactome": "R-DME-8933446", "name": "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10491553" ], "products": [ "species_29370", "species_10491559" ], "modifiers": [ [ "species_10440775", "catalyst" ] ], "additional_components": [ "FBgn0027561", "FBgn0027561" ] }, "reaction_10491962": { "compartment": "compartment_70101", "id": "reaction_10491962", "reactome": "R-DME-8933452", "name": "YWHAE dimer binds phosphorylated DENND1 proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432016", "species_10491559" ], "products": [ "species_10491564" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "FBgn0027561", "A1Z7Q5", "FBgn0027561", "P92177", "14-3-3epsilon" ] }, "reaction_10491614": { "compartment": "compartment_5668575", "id": "reaction_10491614", "reactome": "R-DME-8877760", "name": "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10491593" ], "products": [ "species_10491599", "species_29420", "species_10491105" ], "modifiers": [ [ "species_10491611", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "A1Z7S3", "FBgn0002567", "species_29420", "A1Z7S3", "FBgn0002567", "species_29438", "Q9V8W3", "FBgn0026378", "Q9VLB7", "FBgn0004868", "Q7K3N1", "FBgn0033973", "A1ZAX8", "FBgn0034261" ] }, "reaction_10490413": { "compartment": "compartment_7660", "id": "reaction_10490413", "reactome": "R-DME-8869568", "name": "NPM1 binds TFAP2A homodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489710", "species_10469613" ], "products": [ "species_10490411" ], "modifiers": [ [ "species_5334804", "catalyst" ] ], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0016685", "Q27415", "FBgn0016685", "M9PIH9", "FBgn0261953" ] }, "reaction_10428447": { "compartment": "compartment_5460", "id": "reaction_10428447", "reactome": "R-DME-70870", "name": "ECHS1 hydrates methacrylyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70858", "species_113521" ], "products": [ "species_71847" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10428381": { "compartment": "compartment_5460", "id": "reaction_10428381", "reactome": "R-DME-70745", "name": "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70715" ], "products": [ "species_70744", "species_31649" ], "modifiers": [ [ "species_10428378", "catalyst" ] ], "additional_components": [ "Q9VSL9", "FBgn0035911", "species_113596" ] }, "reaction_10453146": { "compartment": "compartment_5460", "id": "reaction_10453146", "reactome": "R-DME-508473", "name": "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_30004", "species_29362" ], "products": [ "species_113526", "species_573404" ], "modifiers": [ [ "species_10428462", "catalyst" ] ], "additional_components": [ "Q9V8M5", "FBgn0034390" ] }, "reaction_10428473": { "compartment": "compartment_5460", "id": "reaction_10428473", "reactome": "R-DME-70893", "name": "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_30004" ], "products": [ "species_70843", "species_113529", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428470", "catalyst" ] ], "additional_components": [ "FBgn0023537" ] }, "reaction_10453144": { "compartment": "compartment_5460", "id": "reaction_10453144", "reactome": "R-DME-508369", "name": "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_70836", "species_29362" ], "products": [ "species_70829", "species_113526" ], "modifiers": [ [ "species_10428424", "catalyst" ] ], "additional_components": [ "O18404", "FBgn0021765" ] }, "reaction_10428407": { "compartment": "compartment_5460", "id": "reaction_10428407", "reactome": "R-DME-70785", "name": "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70772", "species_113521" ], "products": [ "species_70784" ], "modifiers": [ [ "species_10428404", "catalyst" ] ], "additional_components": [ "A1Z934", "FBgn0033761" ] }, "reaction_10453142": { "compartment": "compartment_5460", "id": "reaction_10453142", "reactome": "R-DME-508308", "name": "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113548", "species_113581", "species_70772", "species_113521" ], "products": [ "species_70744", "species_29896", "species_113593" ], "modifiers": [ [ "species_10428394", "catalyst" ] ], "additional_components": [ "Q9V9T5", "FBgn0039877", "Q9V9A7", "FBgn0042083" ] }, "reaction_10428437": { "compartment": "compartment_5460", "id": "reaction_10428437", "reactome": "R-DME-70844", "name": "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_70836" ], "products": [ "species_70843", "species_113559" ], "modifiers": [ [ "species_10428434", "catalyst" ] ], "additional_components": [ "Q9W3N9", "FBgn0029969" ] }, "reaction_10428371": { "compartment": "compartment_5460", "id": "reaction_10428371", "reactome": "R-DME-70724", "name": "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_508190" ], "products": [ "species_508181", "species_113552" ], "modifiers": [ [ "species_10428368", "catalyst" ] ], "additional_components": [ "CHEBI:58045", "species_29702", "species_351964", "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "Q9VYD5", "FBgn0030482" ] }, "reaction_10453134": { "compartment": "compartment_70101", "id": "reaction_10453134", "reactome": "R-DME-508189", "name": "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_508187" ], "products": [ "species_29406", "species_508182" ], "modifiers": [ [ "species_10428360", "catalyst" ] ], "additional_components": [ "CHEBI:28654", "CHEBI:17865", "CHEBI:16530", "species_351964", "CHEBI:58045", "species_29702", "Q9VYD5", "FBgn0030482" ] }, "reaction_10428455": { "compartment": "compartment_5460", "id": "reaction_10428455", "reactome": "R-DME-70881", "name": "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71847", "species_113521" ], "products": [ "species_29374", "species_573404" ], "modifiers": [ [ "species_10428452", "catalyst" ] ], "additional_components": [ "FBgn0038326" ] }, "reaction_10428417": { "compartment": "compartment_5460", "id": "reaction_10428417", "reactome": "R-DME-70800", "name": "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70718", "species_113596" ], "products": [ "species_70799", "species_31649" ], "modifiers": [ [ "species_10428414", "catalyst" ] ], "additional_components": [ "Q9VVU1", "FBgn0036824", "species_113596" ] }, "reaction_10428352": { "compartment": "compartment_5460", "id": "reaction_10428352", "reactome": "R-DME-70713", "name": "BCKDH transfers CoA group from CoA-SH to BCAAs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_508181" ], "products": [ "species_29362", "species_508261", "species_29376" ], "modifiers": [ [ "species_10428349", "catalyst" ] ], "additional_components": [ "CHEBI:16530", "CHEBI:28654", "CHEBI:17865", "CHEBI:15479", "species_70715", "species_70718", "Q7PLE6", "FBgn0039993", "Q9VHB8", "FBgn0037709", "species_8878387", "Q9VXY3", "FBgn0030612", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10430201": { "compartment": "compartment_7660", "id": "reaction_10430201", "reactome": "R-DME-72180", "name": "Cleavage of mRNA at the 3'-end", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430194" ], "products": [ "species_10430001", "species_10430036", "species_10430196", "species_10430024" ], "modifiers": [ [ "species_10430198", "catalyst" ] ], "additional_components": [ "Q02427", "FBgn0260944", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7KNF2", "FBgn0005648", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q9VE52", "FBgn0027841", "P25991", "FBgn0003559", "Q9V9V0", "FBgn0039867", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q02427", "FBgn0260944", "Q7KNF2", "FBgn0005648", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q0E8G6", "FBgn0035987", "Q9VSH4", "FBgn0035872", "Q7K284", "FBgn0033842", "A1Z9W4", "FBgn0264962" ] }, "reaction_10434116": { "compartment": "compartment_7660", "id": "reaction_10434116", "reactome": "R-DME-111437", "name": "Cleavage of the 3'-end of the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434112" ], "products": [ "species_10434114", "species_10433259" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554" ] }, "reaction_10460039": { "compartment": "compartment_7660", "id": "reaction_10460039", "reactome": "R-DME-1592240", "name": "Formation of NRF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460033", "species_10460035", "species_10460024", "species_10460029", "species_10460031" ], "products": [ "species_10460037" ], "modifiers": [], "additional_components": [ "FBgn0052343", "FBgn0052343", "FBgn0004510", "FBgn0052343", "FBgn0052343", "M9NFF9", "FBgn0052343", "Q04688", "FBgn0004510" ] }, "reaction_10476803": { "compartment": "compartment_5460", "id": "reaction_10476803", "reactome": "R-DME-5688276", "name": "SIRT4 transfers ADPRib to GLUD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428209", "species_113526" ], "products": [ "species_10476793", "species_5688274" ], "modifiers": [ [ "species_10476800", "catalyst" ] ], "additional_components": [ "P54385", "FBgn0001098", "P54385", "FBgn0001098", "Q8IRR5", "FBgn0029783", "species_1562550" ] }, "reaction_10476835": { "compartment": "compartment_5460", "id": "reaction_10476835", "reactome": "R-DME-5688289", "name": "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476821", "species_113526" ], "products": [ "species_5688337", "species_10476825", "species_5688274" ], "modifiers": [ [ "species_10476832", "catalyst" ] ], "additional_components": [ "Q9VP61", "FBgn0012034", "Q00637", "FBgn0010213", "P54385", "FBgn0001098", "Q00637", "FBgn0010213", "Q9VP61", "FBgn0012034", "P54385", "FBgn0001098", "Q9I7I7", "FBgn0038788", "species_1562550" ] }, "reaction_10493564": { "compartment": "compartment_70616", "id": "reaction_10493564", "reactome": "R-DME-8949580", "name": "F1Fo ATP synthase dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436868" ], "products": [ "species_10493562" ], "modifiers": [], "additional_components": [ "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081", "Q24439", "FBgn0016691", "Q9W2X6", "FBgn0028342", "O01666", "FBgn0020235", "Q05825", "FBgn0010217", "Q9VXN2", "FBgn0014391", "P35381", "FBgn0011211", "Q9VKM3", "FBgn0010612", "P00850", "FBgn0013672", "Q6NN09", "FBgn0039830", "Q9W141", "FBgn0035032", "Q24407", "FBgn0016119", "O77134", "FBgn0038224", "Q24251", "FBgn0016120", "Q94516", "FBgn0019644", "A1ZAA9", "FBgn0034081" ] }, "reaction_10458847": { "compartment": "compartment_876", "id": "reaction_10458847", "reactome": "R-DME-1296348", "name": "Activation of TWIK-related K+ channel (TREK)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458844", "catalyst" ] ], "additional_components": [ "Q9VHE0", "FBgn0037690", "Q9VFS9", "FBgn0038165" ] }, "reaction_390116": { "compartment": "compartment_70101", "id": "reaction_390116", "reactome": "R-DME-390116", "name": "Phospho FT reduces D accumulation at the plasma membrane", "reversible": "false", "notes": "There are observations that Fat (FT), Dachsous (DS), and Four-jointed (FJ) modulate the subcellular localisation of Dachs (D). In the absence of FT, D accumulates at the plasma membrane. These suggest a simple model whereby signalling through FT regulates the stability of the serine/threonine kinase, Warts (WTS), by reducing protein levels of D at the plasma membrane so it fails to interact with WTS.", "reactants": [ "species_451851", "species_451889" ], "products": [ "species_390026", "species_451851" ], "modifiers": [], "additional_components": [ "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "FBgn0000411", "FBgn0000411", "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO" ] }, "reaction_451856": { "compartment": "compartment_70101", "id": "reaction_451856", "reactome": "R-DME-451856", "name": "FT is phosphorylated by DCO", "reversible": "false", "notes": "The casein kinase 1 epsilon orthologue, Discs overgrown (DCO) phosphorylates the cytoplasmic part of FT at unknown residues.", "reactants": [ "species_113592", "species_451827" ], "products": [ "species_451851", "species_29370" ], "modifiers": [ [ "species_451827", "catalyst" ] ], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS", "O76324", "DCO", "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "P33450", "Phospho FT", "Q24292", "DS", "O76324", "DCO" ] }, "reaction_451839": { "compartment": "compartment_70101", "id": "reaction_451839", "reactome": "R-DME-451839", "name": "DCO binds to FT", "reversible": "false", "notes": "Fat (FT) is cleaved in its extracellular domain at an unknown site with the two fragments produced remaining stably associated after processing. The casein kinase 1 epsilon orthologue, Discs overgrown (DCO) binds to the cytoplasmic part of FT.", "reactants": [ "species_350966", "species_205729" ], "products": [ "species_451827" ], "modifiers": [], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS", "P33450", "Phospho FT", "Q24292", "DS", "O76324", "DCO" ] }, "reaction_350440": { "compartment": "compartment_876", "id": "reaction_350440", "reactome": "R-DME-350440", "name": "FT binds to DS in an adjacent cell", "reversible": "false", "notes": "The transmembrane non-classical cadherin Fat (FT) binds extracellularly to the transmembrane non-classical cadherin Dachsous (DS) in adjacent cells.", "reactants": [ "species_351124", "species_351109" ], "products": [ "species_350966" ], "modifiers": [], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS" ] }, "reaction_10431303": { "compartment": "compartment_5460", "id": "reaction_10431303", "reactome": "R-DME-73920", "name": "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_73911" ], "products": [ "species_113529", "species_73909", "species_29362" ], "modifiers": [ [ "species_10431288", "catalyst" ] ], "additional_components": [ "Q7K3N4", "FBgn0033679" ] }, "reaction_10431475": { "compartment": "compartment_5460", "id": "reaction_10431475", "reactome": "R-DME-74177", "name": "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70958", "species_73909" ], "products": [ "species_73871", "species_113536" ], "modifiers": [ [ "species_10431472", "catalyst" ] ], "additional_components": [ "Q9W058", "FBgn0035298" ] }, "reaction_10449897": { "compartment": "compartment_70101", "id": "reaction_10449897", "reactome": "R-DME-443439", "name": "c-Src binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446844", "species_10447582" ], "products": [ "species_10449895" ], "modifiers": [], "additional_components": [ "FBgn0262733", "P00528", "FBgn0262733", "P11346", "Raf" ] }, "reaction_10449912": { "compartment": "compartment_70101", "id": "reaction_10449912", "reactome": "R-DME-443831", "name": "14-3-3-zeta binds Raf1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432006", "species_10446844" ], "products": [ "species_10449910" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P11346", "Raf", "P29310", "14-3-3zeta" ] }, "reaction_10433182": { "compartment": "compartment_5460", "id": "reaction_10433182", "reactome": "R-DME-77299", "name": "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77281" ], "products": [ "species_77284", "species_31649" ], "modifiers": [ [ "species_10433179", "catalyst" ] ], "additional_components": [ "A1ZBJ2", "FBgn0034432" ] }, "reaction_10433188": { "compartment": "compartment_5460", "id": "reaction_10433188", "reactome": "R-DME-77304", "name": "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77302" ], "products": [ "species_77272", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433186": { "compartment": "compartment_5460", "id": "reaction_10433186", "reactome": "R-DME-77303", "name": "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_77300" ], "products": [ "species_113529", "species_77302", "species_29362" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433184": { "compartment": "compartment_5460", "id": "reaction_10433184", "reactome": "R-DME-77301", "name": "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77284", "species_113521" ], "products": [ "species_77300" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10427815": { "compartment": "compartment_7660", "id": "reaction_10427815", "reactome": "R-DME-69685", "name": "CHEK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427808", "species_29358" ], "products": [ "species_113582", "species_10427813" ], "modifiers": [ [ "species_10427797", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0019686" ] }, "reaction_10474328": { "compartment": "compartment_7660", "id": "reaction_10474328", "reactome": "R-DME-5628871", "name": "BRD7 promotes EP300-mediated acetylation of TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467732", "species_113560" ], "products": [ "species_2485002", "species_10474325" ], "modifiers": [ [ "species_10467732", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947", "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947", "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947" ] }, "reaction_10467734": { "compartment": "compartment_7660", "id": "reaction_10467734", "reactome": "R-DME-3222093", "name": "BRD7 binds TP53 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467730", "species_10427813", "species_10458126" ], "products": [ "species_10467732" ], "modifiers": [], "additional_components": [ "FBgn0031947", "Q8IMZ4", "FBgn0039044", "FBgn0261617", "M9MS40", "FBgn0261617", "Q8IMZ4", "FBgn0039044", "Q9VLX2", "FBgn0031947" ] }, "reaction_10486189": { "compartment": "compartment_7660", "id": "reaction_10486189", "reactome": "R-DME-6805650", "name": "MTA2-NuRD complex deacetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10486149" ], "products": [ "species_10486151", "species_5566518" ], "modifiers": [ [ "species_10486186", "catalyst" ] ], "additional_components": [ "Q94517", "HDAC1", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q24572", "FBgn0263979" ] }, "reaction_10491585": { "compartment": "compartment_7660", "id": "reaction_10491585", "reactome": "R-DME-8877691", "name": "MAP2K6 phosphorylates PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491571" ], "products": [ "species_113582", "species_10491582" ], "modifiers": [ [ "species_10450891", "catalyst" ] ], "additional_components": [ "Q8SXX1", "FBgn0039924", "Q8SXX1", "FBgn0039924", "FBgn0261524" ] }, "reaction_10487140": { "compartment": "compartment_7660", "id": "reaction_10487140", "reactome": "R-DME-6811508", "name": "ING2-bound EP300 acetylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487130", "species_113560" ], "products": [ "species_2485002", "species_10487137" ], "modifiers": [ [ "species_10487130", "catalyst" ], [ "species_6810408", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044", "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044", "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10491589": { "compartment": "compartment_7660", "id": "reaction_10491589", "reactome": "R-DME-8877692", "name": "PIN1 binds phosphorylated PIP4K2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491582", "species_10455258" ], "products": [ "species_10491587" ], "modifiers": [], "additional_components": [ "Q8SXX1", "FBgn0039924", "FBgn0015379", "P54353", "FBgn0015379", "Q8SXX1", "FBgn0039924" ] }, "reaction_10486887": { "compartment": "compartment_7660", "id": "reaction_10486887", "reactome": "R-DME-6810376", "name": "ING2 binds PI5P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6810408", "species_10469624" ], "products": [ "species_10486885" ], "modifiers": [], "additional_components": [ "FBgn0038546", "Q9VEF5", "FBgn0038546", "species_1806212" ] }, "reaction_10487132": { "compartment": "compartment_7660", "id": "reaction_10487132", "reactome": "R-DME-6811479", "name": "ING2 recruits EP300 to TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10469624", "species_10458126" ], "products": [ "species_10487130" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0038546", "FBgn0261617", "M9MS40", "FBgn0261617", "Q9VEF5", "FBgn0038546", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10454653": { "compartment": "compartment_70101", "id": "reaction_10454653", "reactome": "R-DME-913996", "name": "PKA/PKG phosphorylate Rap1GAP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446818", "species_113592" ], "products": [ "species_10454640", "species_29370" ], "modifiers": [ [ "species_10454650", "catalyst" ] ], "additional_components": [ "FBgn0264895", "FBgn0264895", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "Q03042", "FBgn0000442" ] }, "reaction_10446840": { "compartment": "compartment_70101", "id": "reaction_10446840", "reactome": "R-DME-392834", "name": "Activation of EPACs by cAMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10446030" ], "products": [ "species_10446032" ], "modifiers": [], "additional_components": [ "FBgn0085421", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10446823": { "compartment": "compartment_70101", "id": "reaction_10446823", "reactome": "R-DME-392513", "name": "Rap1 signal termination by Rap1GAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444262" ], "products": [ "species_111294", "species_10444300" ], "modifiers": [ [ "species_10446816", "catalyst" ], [ "species_10446821", "inhibitor" ] ], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "P08645", "FBgn0004636", "species_29420", "FBgn0264895", "P29310", "14-3-3zeta", "A8DYW8", "FBgn0264895" ] }, "reaction_10454642": { "compartment": "compartment_70101", "id": "reaction_10454642", "reactome": "R-DME-913993", "name": "14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446818", "species_10432008" ], "products": [ "species_10446821" ], "modifiers": [ [ "species_10454640", "inhibitor" ] ], "additional_components": [ "FBgn0264895", "P29310", "14-3-3zeta", "A8DYW8", "FBgn0264895", "FBgn0264895" ] }, "reaction_10446848": { "compartment": "compartment_70101", "id": "reaction_10446848", "reactome": "R-DME-392835", "name": "Rap1 sequesters Raf1 to inhibit ERK cascade", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444262", "species_10446844" ], "products": [ "species_10446846" ], "modifiers": [], "additional_components": [ "P08645", "FBgn0004636", "species_29438", "P11346", "Raf", "P08645", "FBgn0004636", "species_29438" ] }, "reaction_10433100": { "compartment": "compartment_7660", "id": "reaction_10433100", "reactome": "R-DME-77071", "name": "Phosphorylation (Ser5) of RNA pol II CTD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10433097" ], "products": [ "species_113582", "species_10433093" ], "modifiers": [ [ "species_10433097", "catalyst" ] ], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10434824": { "compartment": "compartment_7660", "id": "reaction_10434824", "reactome": "R-DME-113430", "name": "Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433097" ], "products": [ "species_10433097" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10472491": { "compartment": "compartment_5460", "id": "reaction_10472491", "reactome": "R-DME-5419261", "name": "55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472480", "species_10472487" ], "products": [ "species_10472489" ], "modifiers": [], "additional_components": [ "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VM33", "FBgn0263133", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VM33", "FBgn0263133" ] }, "reaction_10472506": { "compartment": "compartment_5460", "id": "reaction_10472506", "reactome": "R-DME-5419264", "name": "MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472502", "species_113573", "species_10472493" ], "products": [ "species_10472504" ], "modifiers": [], "additional_components": [ "Q9VKU3", "FBgn0032261", "Q9VK20", "FBgn0032486", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VK20", "FBgn0032486" ] }, "reaction_10472535": { "compartment": "compartment_5460", "id": "reaction_10472535", "reactome": "R-DME-5419281", "name": "MRRF binds 55S ribosome:mRNA:tRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472524", "species_10472510" ], "products": [ "species_10472533" ], "modifiers": [], "additional_components": [ "FBgn0035980", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "Q9VSW4", "FBgn0035980", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555" ] }, "reaction_10472531": { "compartment": "compartment_5460", "id": "reaction_10472531", "reactome": "R-DME-5419273", "name": "Hydrolysis of GTP and dissociation of 28S and 39S subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472526" ], "products": [ "species_10472528", "species_113548", "species_10472216", "species_10472474", "species_10472524" ], "modifiers": [ [ "species_10472526", "catalyst" ] ], "additional_components": [ "Q9VSW4", "FBgn0035980", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10472504" ], "products": [ "species_113548", "species_10472502", "species_5419287", "species_113525", "species_10472510" ], "modifiers": [], "additional_components": [ "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555", "species_29438", "Q9VK20", "FBgn0032486", "Q9VKU3", "FBgn0032261", "Q9VK20", "FBgn0032486", "Q9VLJ9", "FBgn0032053", "Q9VMY1", "FBgn0031651", "Q7JWG9", "FBgn0033208", "Q86BM8", "FBgn0053002", "A1Z9J6", "FBgn0050481", "Q9VMX0", "FBgn0031660", "Q9W2M8", "FBgn0034579", "Q9VXQ0", "FBgn0030686", "Q9VE04", "FBgn0038678", "Q9W4I3", "FBgn0029718", "Q9W547", "FBgn0023519", "Q9VNC1", "FBgn0037330", "Q9W0S6", "FBgn0035122", "Q9VCX3", "FBgn0263863", "Q7JVK1", "FBgn0026741", "Q9W086", "FBgn0035272", "Q9VHN6", "FBgn0037608", "Q8T3V6", "FBgn0014023", "Q9VTF8", "FBgn0036135", "Q9VQ35", "FBgn0031357", "Q9VVX4", "FBgn0036853", "Q9VYI3", "FBgn0030433", "Q9VY48", "FBgn0030552", "Q9VPL3", "FBgn0031231", "Q9VUJ0", "FBgn0036462", "Q9VFJ2", "FBgn0038234", "Q9V3D0", "FBgn0001995", "Q9VSR5", "FBgn0011787", "Q9VGP7", "FBgn0037892", "Q9VJ38", "FBgn0032720", "Q7JZM8", "FBgn0034001", "Q9W4Z2", "FBgn0040389", "Q7K0A0", "FBgn0033480", "Q9VPF6", "FBgn0036990", "Q9W1L1", "FBgn0034893", "Q9VF89", "FBgn0038319", "Q9V9Z1", "FBgn0039835", "Q9VP13", "FBgn0037102", "Q9W4L1", "FBgn0040907", "Q9VKU3", "FBgn0032261", "Q0E959", "FBgn0083983", "Q8MS27", "FBgn0038923", "Q9W551", "FBgn0026089", "Q9I7Q9", "FBgn0042112", "Q9Y171", "FBgn0027615", "Q9VGW9", "FBgn0261380", "Q9VHT5", "FBgn0037566", "Q9W021", "FBgn0035335", "Q9V3E3", "FBgn0028648", "Q9VXB5", "FBgn0030786", "Q8SYP9", "FBgn0287187", "Q8I0J3", "FBgn0044511", "Q9VZX6", "FBgn0035374", "Q9W199", "FBgn0034986", "Q9VG07", "FBgn0038106", "Q9VV39", "FBgn0285951", "Q9V6Y3", "FBgn0033907", "Q8MSS7", "FBgn0031639", "Q9VEV5", "FBgn0038426", "Q8WTC1", "FBgn0026261", "A1Z9A8", "FBgn0033816", "Q9VUX1", "FBgn0036557", "Q9VWI3", "FBgn0044030", "Q9W253", "FBgn0034727", "Q9VXP3", "FBgn0030692", "P10735", "FBgn0003714", "Q9W114", "FBgn0040666", "A1ZBA5", "FBgn0034361", "Q9VEN6", "FBgn0038474", "O77477", "FBgn0025336", "Q9VA81", "FBgn0039765", "Q9VIN9", "FBgn0032849", "Q9VFB2", "FBgn0038307", "Q9VVN2", "FBgn0036774", "Q9VY28", "FBgn0030572", "Q8SXF0", "FBgn0037529", "Q9VCC3", "FBgn0039159", "Q9VKX4", "FBgn0032236", "Q8IP62", "FBgn0260407", "Q9VZD5", "FBgn0035534", "Q9VAY9", "FBgn0039555" ] }, "reaction_10497334": { "compartment": "compartment_17947", "id": "reaction_10497334", "reactome": "R-DME-9603775", "name": "PEX3:PEX19:class I PMP dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497318" ], "products": [ "species_10446324", "species_10497332", "species_10446302" ], "modifiers": [], "additional_components": [ "Q9VUL8", "FBgn0036484", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407", "FBgn0032407", "Q9VZD9", "FBgn0052250", "Q9VL02", "FBgn0005322", "B7YZT2", "FBgn0039969", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q7JZE1", "FBgn0034058", "Q7JRD4", "FBgn0033812", "Q7JUN3", "FBgn0039890", "Q9VPB8", "FBgn0037020", "Q9VQI6", "FBgn0031478", "FBgn0036484" ] }, "reaction_10497336": { "compartment": "compartment_17947", "id": "reaction_10497336", "reactome": "R-DME-9603784", "name": "PEX19:class I PMP binds PEX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497316", "species_10446302" ], "products": [ "species_10497318" ], "modifiers": [], "additional_components": [ "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407", "FBgn0036484", "Q9VUL8", "FBgn0036484", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407" ] }, "reaction_10497338": { "compartment": "compartment_70101", "id": "reaction_10497338", "reactome": "R-DME-9603804", "name": "PEX19 binds class I peroxisomal membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446324", "species_10497314" ], "products": [ "species_10497316" ], "modifiers": [], "additional_components": [ "FBgn0032407", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q7JZE1", "FBgn0034058", "B7YZT2", "FBgn0039969", "Q9VQI6", "FBgn0031478", "Q9VRJ3", "FBgn0035587", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VPB9", "FBgn0037019", "Q9VWC8", "FBgn0031069", "A0A0S0WGR0", "FBgn0035252", "Q9VZD9", "FBgn0052250", "Q7JUN3", "FBgn0039890", "Q9VL02", "FBgn0005322", "Q8IP97", "FBgn0032407" ] }, "reaction_10497233": { "compartment": "compartment_70101", "id": "reaction_10497233", "reactome": "R-DME-9033509", "name": "USP9X binds Ub:PEX5L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454130", "species_10497208" ], "products": [ "species_10497210" ], "modifiers": [], "additional_components": [ "FBgn0005632", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P55824", "FBgn0005632" ] }, "reaction_10497248": { "compartment": "compartment_17951", "id": "reaction_10497248", "reactome": "R-DME-9033520", "name": "TYSND1 cleaves TYSND1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_10497187" ], "products": [ "species_10497245", "species_10497243" ], "modifiers": [ [ "species_10497187", "catalyst" ] ], "additional_components": [ "FBgn0035065", "FBgn0035065", "FBgn0035065", "FBgn0035065" ] }, "reaction_10497250": { "compartment": "compartment_17947", "id": "reaction_10497250", "reactome": "R-DME-9033527", "name": "PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497197", "species_10495029" ], "products": [ "species_10497199" ], "modifiers": [], "additional_components": [ "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497204": { "compartment": "compartment_17947", "id": "reaction_10497204", "reactome": "R-DME-9033485", "name": "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497199" ], "products": [ "species_10427563", "species_10497201" ], "modifiers": [ [ "species_10497199", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497191": { "compartment": "compartment_17947", "id": "reaction_10497191", "reactome": "R-DME-9033235", "name": "Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497173" ], "products": [ "species_10497189", "species_10495027" ], "modifiers": [], "additional_components": [ "Q7KML2", "FBgn0027572", "Q9VRJ4", "FBgn0035588", "Q27571", "FBgn0011676", "Q7JZB1", "FBgn0033543", "Q9VM80", "FBgn0031860", "Q9V492", "FBgn0039930", "A1Z8D3", "FBgn0061356", "Q9W2G8", "FBgn0034629", "Q9W2G9", "FBgn0034628", "Q9W3U0", "FBgn0029924", "Q9W106", "FBgn0035065", "B7Z028", "FBgn0031813", "B7Z0E0", "FBgn0001248", "Q9VXJ0", "FBgn0030731", "Q8SXR7", "FBgn0034999", "E1JHE4", "FBgn0267828", "Q7KVJ6", "FBgn0265187", "Q9W5W8", "FBgn0031092", "Q9W3Z3", "FBgn0014031", "Q7K3B7", "FBgn0034488", "Q9VHN8", "FBgn0037606", "Q9VIK0", "FBgn0032881", "Q9VM58", "FBgn0031877", "Q9VEM4", "FBgn0038486", "Q9VB02", "FBgn0039543", "P22817", "FBgn0001247", "P17336", "FBgn0000261", "Q9VIV6", "FBgn0032790", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9VIV6", "FBgn0032790", "Q9V492", "FBgn0039930", "Q9VXJ0", "FBgn0030731", "Q9W106", "FBgn0035065", "B7Z0E0", "FBgn0001248", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999", "A1Z8D3", "FBgn0061356", "Q9VM80", "FBgn0031860", "Q7JZB1", "FBgn0033543", "Q9VHN8", "FBgn0037606", "Q9W5W8", "FBgn0031092", "Q9VEM4", "FBgn0038486", "Q9VIK0", "FBgn0032881", "Q9W3Z3", "FBgn0014031", "Q9VM58", "FBgn0031877", "P22817", "FBgn0001247", "Q7K3B7", "FBgn0034488", "P17336", "FBgn0000261", "B7Z028", "FBgn0031813", "Q9VRJ4", "FBgn0035588", "Q9VB02", "FBgn0039543", "Q27571", "FBgn0011676", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497193": { "compartment": "compartment_17947", "id": "reaction_10497193", "reactome": "R-DME-9033236", "name": "PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497171", "species_10497169" ], "products": [ "species_10497173" ], "modifiers": [], "additional_components": [ "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q7KML2", "FBgn0027572", "Q9VRJ4", "FBgn0035588", "Q27571", "FBgn0011676", "Q7JZB1", "FBgn0033543", "Q9VM80", "FBgn0031860", "Q9V492", "FBgn0039930", "A1Z8D3", "FBgn0061356", "Q9W2G8", "FBgn0034629", "Q9W2G9", "FBgn0034628", "Q9W3U0", "FBgn0029924", "Q9W106", "FBgn0035065", "B7Z028", "FBgn0031813", "B7Z0E0", "FBgn0001248", "Q9VXJ0", "FBgn0030731", "Q8SXR7", "FBgn0034999", "E1JHE4", "FBgn0267828", "Q7KVJ6", "FBgn0265187", "Q9W5W8", "FBgn0031092", "Q9W3Z3", "FBgn0014031", "Q7K3B7", "FBgn0034488", "Q9VHN8", "FBgn0037606", "Q9VIK0", "FBgn0032881", "Q9VM58", "FBgn0031877", "Q9VEM4", "FBgn0038486", "Q9VB02", "FBgn0039543", "P22817", "FBgn0001247", "P17336", "FBgn0000261", "Q9VIV6", "FBgn0032790", "O46085", "FBgn0023516", "Q7KML2", "FBgn0027572", "Q9VRJ4", "FBgn0035588", "Q27571", "FBgn0011676", "Q7JZB1", "FBgn0033543", "Q9VM80", "FBgn0031860", "Q9V492", "FBgn0039930", "A1Z8D3", "FBgn0061356", "Q9W2G8", "FBgn0034629", "Q9W2G9", "FBgn0034628", "Q9W3U0", "FBgn0029924", "Q9W106", "FBgn0035065", "B7Z028", "FBgn0031813", "B7Z0E0", "FBgn0001248", "Q9VXJ0", "FBgn0030731", "Q8SXR7", "FBgn0034999", "E1JHE4", "FBgn0267828", "Q7KVJ6", "FBgn0265187", "Q9W5W8", "FBgn0031092", "Q9W3Z3", "FBgn0014031", "Q7K3B7", "FBgn0034488", "Q9VHN8", "FBgn0037606", "Q9VIK0", "FBgn0032881", "Q9VM58", "FBgn0031877", "Q9VEM4", "FBgn0038486", "Q9VB02", "FBgn0039543", "P22817", "FBgn0001247", "P17336", "FBgn0000261", "Q9VIV6", "FBgn0032790", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020" ] }, "reaction_10497241": { "compartment": "compartment_17947", "id": "reaction_10497241", "reactome": "R-DME-9033514", "name": "Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497237" ], "products": [ "species_10497197", "species_10497239" ], "modifiers": [], "additional_components": [ "Q9VSN7", "FBgn0035922", "Q9V778", "FBgn0033983", "O46085", "FBgn0023516", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "Q9W0D7", "FBgn0035233", "Q9VPT5", "FBgn0031282", "O46085", "FBgn0023516", "Q9VSN7", "FBgn0035922", "Q7JRD4", "FBgn0033812", "Q9VPB8", "FBgn0037020", "FBgn0033983" ] }, "reaction_10497213": { "compartment": "compartment_70101", "id": "reaction_10497213", "reactome": "R-DME-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10497210" ], "products": [ "species_10497167", "species_10454130", "species_10426987" ], "modifiers": [ [ "species_10497210", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P55824", "FBgn0005632", "FBgn0023516", "FBgn0005632", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "O46085", "FBgn0023516", "P55824", "FBgn0005632" ] }, "reaction_10497087": { "compartment": "compartment_70101", "id": "reaction_10497087", "reactome": "R-DME-9033232", "name": "PEX7 binds cargo proteins containing PTS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497083", "species_10497078" ], "products": [ "species_10497085" ], "modifiers": [], "additional_components": [ "FBgn0033983", "FBgn0035922", "Q9VSN7", "FBgn0035922", "Q9V778", "FBgn0033983" ] }, "reaction_10497622": { "compartment": "compartment_70101", "id": "reaction_10497622", "reactome": "R-DME-9617595", "name": "SGTA binds mislocalized membrane protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497405", "species_10497618" ], "products": [ "species_10497620" ], "modifiers": [], "additional_components": [ "Q9VJD4", "FBgn0032640", "P14599", "FBgn0000108", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "P14599", "FBgn0000108", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9VJD4", "FBgn0032640" ] }, "reaction_10497453": { "compartment": "compartment_70101", "id": "reaction_10497453", "reactome": "R-DME-9609921", "name": "SGTA binds Tail-anchored protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497405", "species_10497449" ], "products": [ "species_10497451" ], "modifiers": [], "additional_components": [ "Q9VJD4", "FBgn0032640", "Q24509", "FBgn0011708", "Q7JZN0", "FBgn0010638", "Q9V4N3", "FBgn0264294", "Q9VJC0", "FBgn0032652", "Q9VUZ3", "FBgn0036575", "Q8IRR0", "FBgn0029854", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9VWE9", "FBgn0031049", "Q9VGJ9", "FBgn0037933", "Q8SYY6", "FBgn0047135", "Q9VEJ4", "FBgn0038515", "B7Z0E5", "FBgn0266757", "Q24547", "FBgn0013343", "Q24509", "FBgn0011708", "Q7JZN0", "FBgn0010638", "Q9V4N3", "FBgn0264294", "Q9VJC0", "FBgn0032652", "Q9VUZ3", "FBgn0036575", "Q8IRR0", "FBgn0029854", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9VWE9", "FBgn0031049", "Q9VGJ9", "FBgn0037933", "Q8SYY6", "FBgn0047135", "Q9VEJ4", "FBgn0038515", "B7Z0E5", "FBgn0266757", "Q24547", "FBgn0013343", "Q9VJD4", "FBgn0032640" ] }, "reaction_10495803": { "compartment": "compartment_5460", "id": "reaction_10495803", "reactome": "R-DME-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495795" ], "products": [], "modifiers": [ [ "species_10495800", "catalyst" ] ], "additional_components": [ "Q9W3X7", "FBgn0029888", "FBgn0033005" ] }, "reaction_10462211": { "compartment": "compartment_70616", "id": "reaction_10462211", "reactome": "R-DME-1955380", "name": "TIMM9:TIMM10 transfers proteins to TIMM22", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10462198", "species_10462173", "species_10462205" ], "products": [ "species_10462209" ], "modifiers": [], "additional_components": [ "Q26365", "FBgn0003360", "Q9W2D6", "FBgn0027360", "Q9VYD7", "FBgn0030480", "FBgn0051229", "FBgn0027358", "Q9Y0V3", "FBgn0027358", "Q9W2D6", "FBgn0027360", "Q9VYD7", "FBgn0030480", "Q8IN78", "FBgn0051229", "Q26365", "FBgn0003360" ] }, "reaction_10471823": { "compartment": "compartment_70101", "id": "reaction_10471823", "reactome": "R-DME-5358494", "name": "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10471803" ], "products": [ "species_353106", "species_10471790" ], "modifiers": [ [ "species_10471820", "catalyst" ] ], "additional_components": [ "FBgn0000559", "FBgn0000559", "Q9VGQ9", "FBgn0037883", "Q9VFE9", "FBgn0038272", "Q9VTM2", "FBgn0036194" ] }, "reaction_10471787": { "compartment": "compartment_70101", "id": "reaction_10471787", "reactome": "R-DME-5358475", "name": "DPH6 ligates ammonium to diphthine-EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471779", "species_113592", "species_31633" ], "products": [ "species_111294", "species_10435612", "species_76577" ], "modifiers": [ [ "species_10471784", "catalyst" ] ], "additional_components": [ "FBgn0000559", "FBgn0000559", "FBgn0030336" ] }, "reaction_10471801": { "compartment": "compartment_70101", "id": "reaction_10471801", "reactome": "R-DME-5358484", "name": "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10471790" ], "products": [ "species_10471793", "species_71285" ], "modifiers": [ [ "species_10471798", "catalyst" ] ], "additional_components": [ "FBgn0000559", "FBgn0000559", "FBgn0024558" ] }, "reaction_10479423": { "compartment": "compartment_70101", "id": "reaction_10479423", "reactome": "R-DME-6782628", "name": "USP8 deubiquitinates STAM2:HGS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479418" ], "products": [ "species_10426987", "species_10479420" ], "modifiers": [ [ "species_10479418", "catalyst" ] ], "additional_components": [ "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VDD8", "FBgn0038862", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VDD8", "FBgn0038862", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "Q9VDD8", "FBgn0038862" ] }, "reaction_10479326": { "compartment": "compartment_70101", "id": "reaction_10479326", "reactome": "R-DME-6781899", "name": "USP13 binds SIAH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479271", "species_10444782" ], "products": [ "species_10479324" ], "modifiers": [], "additional_components": [ "FBgn0035402", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q9W4W4", "FBgn0024997", "Q8T3Y0", "FBgn0259794", "P21461", "FBgn0003410", "Q9VZU7", "FBgn0035402" ] }, "reaction_10477596": { "compartment": "compartment_7660", "id": "reaction_10477596", "reactome": "R-DME-5690080", "name": "USP3,SAGA deubiquitinate Histone H2A,H2B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477591" ], "products": [ "species_10427430", "species_10477593" ], "modifiers": [ [ "species_10477591", "catalyst" ] ], "additional_components": [ "Q27272", "FBgn0000617", "M9PHZ1", "FBgn0030891", "Q9XZT7", "FBgn0026324", "Q8I8V0", "FBgn0037555", "Q9VVR1", "FBgn0013717", "Q9VTZ1", "FBgn0020388", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q27272", "FBgn0000617", "M9PHZ1", "FBgn0030891", "Q9XZT7", "FBgn0026324", "Q8I8V0", "FBgn0037555", "Q9VVR1", "FBgn0013717", "Q9VTZ1", "FBgn0020388", "Q27272", "FBgn0000617", "M9PHZ1", "FBgn0030891", "Q9XZT7", "FBgn0026324", "Q8I8V0", "FBgn0037555", "Q9VVR1", "FBgn0013717", "Q9VTZ1", "FBgn0020388" ] }, "reaction_10477625": { "compartment": "compartment_70101", "id": "reaction_10477625", "reactome": "R-DME-5690159", "name": "USP21 deubiquitinates RIPK1,DDX58", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477618", "species_29356" ], "products": [ "species_10477620", "species_10477101" ], "modifiers": [ [ "species_10477618", "catalyst" ] ], "additional_components": [ "Q8IQ27", "FBgn0031187", "P83104", "FBgn0046689", "Q8IQ27", "FBgn0031187", "P83104", "FBgn0046689", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8IQ27", "FBgn0031187", "P83104", "FBgn0046689" ] }, "reaction_10477496": { "compartment": "compartment_7660", "id": "reaction_10477496", "reactome": "R-DME-5689950", "name": "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477261" ], "products": [ "species_10477267", "species_10477493" ], "modifiers": [ [ "species_10477261", "catalyst" ] ], "additional_components": [ "Q7KMQ6", "Pten", "Q95V55", "foxo", "Q8IMZ4", "FBgn0039044", "Q9VYQ8", "FBgn0030366", "Q7KMQ6", "Pten", "Q95V55", "foxo", "Q8IMZ4", "FBgn0039044", "Q9VYQ8", "FBgn0030366", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q7KMQ6", "Pten", "Q95V55", "foxo", "Q8IMZ4", "FBgn0039044", "Q9VYQ8", "FBgn0030366" ] }, "reaction_10477112": { "compartment": "compartment_70101", "id": "reaction_10477112", "reactome": "R-DME-5689539", "name": "ADRM1:26S proteaseome binds USP14", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477108", "species_10475480" ], "products": [ "species_10477110" ], "modifiers": [], "additional_components": [ "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q9VKZ8", "Usp14" ] }, "reaction_10479189": { "compartment": "compartment_70101", "id": "reaction_10479189", "reactome": "R-DME-5696600", "name": "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479180" ], "products": [ "species_10479186", "species_10477101" ], "modifiers": [ [ "species_10479180", "catalyst" ] ], "additional_components": [ "Q9VRP5", "FBgn0260936", "Q9U1H8", "FBgn0029121", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q9VRP5", "FBgn0260936", "Q03019", "FBgn0002673", "P20483", "FBgn0003525", "Q9U1H8", "FBgn0029121", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VRP5", "FBgn0260936", "Q9U1H8", "FBgn0029121", "Q03019", "FBgn0002673", "P20483", "FBgn0003525" ] }, "reaction_10479220": { "compartment": "compartment_70101", "id": "reaction_10479220", "reactome": "R-DME-5696627", "name": "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479215" ], "products": [ "species_10479217", "species_10437507" ], "modifiers": [ [ "species_10479215", "catalyst" ] ], "additional_components": [ "P83104", "FBgn0046689", "Q9W3I9", "FBgn0265464", "Q8IPC5", "FBgn0032210", "P83104", "FBgn0046689", "Q9W3I9", "FBgn0265464", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P83104", "FBgn0046689", "Q9W3I9", "FBgn0265464", "Q8IPC5", "FBgn0032210" ] }, "reaction_10479281": { "compartment": "compartment_70101", "id": "reaction_10479281", "reactome": "R-DME-6781779", "name": "USP13 deubiquitinates BECN1,USP10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10479276" ], "products": [ "species_10437507", "species_10479278" ], "modifiers": [ [ "species_10479276", "catalyst" ] ], "additional_components": [ "Q9VCE1", "FBgn0264325", "Q9VZU7", "FBgn0035402", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402", "Q9VCE1", "FBgn0264325", "Q9VCE1", "FBgn0264325", "Q9VZU7", "FBgn0035402" ] }, "reaction_10477646": { "compartment": "compartment_70101", "id": "reaction_10477646", "reactome": "R-DME-5690196", "name": "USP8 deubiquitinates RNF128", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477637" ], "products": [ "species_10454480", "species_10477643" ], "modifiers": [ [ "species_10477637", "catalyst" ] ], "additional_components": [ "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q9VDD8", "FBgn0038862", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q9VDD8", "FBgn0038862", "Q9VL00", "FBgn0032214", "Q06003", "FBgn0004919", "Q9VDD8", "FBgn0038862" ] }, "reaction_10479438": { "compartment": "compartment_7660", "id": "reaction_10479438", "reactome": "R-DME-6782820", "name": "USP17 deubiquitinates SUDS3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479431" ], "products": [ "species_10477395", "species_10479435" ], "modifiers": [ [ "species_10479431", "catalyst" ] ], "additional_components": [ "Q9VRP5", "FBgn0260936", "Q9VWG2", "FBgn0031036", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9VRP5", "FBgn0260936", "Q9VWG2", "FBgn0031036", "Q9VRP5", "FBgn0260936", "Q9VWG2", "FBgn0031036" ] }, "reaction_10477515": { "compartment": "compartment_7660", "id": "reaction_10477515", "reactome": "R-DME-5689973", "name": "USP10,USP24,USP42 deubiquitinate TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477510" ], "products": [ "species_10477493", "species_10477512" ], "modifiers": [ [ "species_10477510", "catalyst" ] ], "additional_components": [ "Q7JQI1", "FBgn0033738", "Q9VRP5", "FBgn0260936", "Q8IMZ4", "FBgn0039044", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q7JQI1", "FBgn0033738", "Q9VRP5", "FBgn0260936", "Q8IMZ4", "FBgn0039044", "Q7JQI1", "FBgn0033738", "Q9VRP5", "FBgn0260936", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10479211": { "compartment": "compartment_7660", "id": "reaction_10479211", "reactome": "R-DME-5696605", "name": "USP12, USP26 deubiquitinate AR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479206" ], "products": [ "species_10477493", "species_10479208" ], "modifiers": [ [ "species_10479206", "catalyst" ] ], "additional_components": [ "Q8WS79", "FBgn0035849", "Q9VBC4", "FBgn0039451", "Q9VCT9", "FBgn0039025", "Q1LZ08", "FBgn0033607", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q8WS79", "FBgn0035849", "Q9VBC4", "FBgn0039451", "Q9VCT9", "FBgn0039025", "Q1LZ08", "FBgn0033607", "Q8WS79", "FBgn0035849", "Q9VBC4", "FBgn0039451", "Q9VCT9", "FBgn0039025", "Q1LZ08", "FBgn0033607" ] }, "reaction_10477608": { "compartment": "compartment_70101", "id": "reaction_10477608", "reactome": "R-DME-5690152", "name": "USP5 cleaves polyubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477603" ], "products": [ "species_10477605", "species_10426987" ], "modifiers": [ [ "species_10477603", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VZU7", "FBgn0035402" ] }, "reaction_10479269": { "compartment": "compartment_7660", "id": "reaction_10479269", "reactome": "R-DME-5697009", "name": "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479262" ], "products": [ "species_10479266", "species_10477493" ], "modifiers": [ [ "species_10479262", "catalyst" ] ], "additional_components": [ "O18413", "Rpt6", "Q9VH07", "FBgn0040078", "P14785", "FBgn0000404", "Q9VZP3", "FBgn0010317", "O18413", "Rpt6", "Q9VH07", "FBgn0040078", "P14785", "FBgn0000404", "Q9VZP3", "FBgn0010317", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "O18413", "Rpt6", "Q9VH07", "FBgn0040078", "P14785", "FBgn0000404", "Q9VZP3", "FBgn0010317" ] }, "reaction_10479459": { "compartment": "compartment_7660", "id": "reaction_10479459", "reactome": "R-DME-6783177", "name": "USP21 deubiquitinates GATA3,IL33", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10479454" ], "products": [ "species_10479456", "species_10477493" ], "modifiers": [ [ "species_10479454", "catalyst" ] ], "additional_components": [ "Q9VKZ0", "FBgn0032223", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q8IQ27", "FBgn0031187", "Q8IQ27", "FBgn0031187", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q9VKZ0", "FBgn0032223", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9VKZ0", "FBgn0032223", "P91623", "FBgn0001138", "P52172", "FBgn0003507", "Q8IQ27", "FBgn0031187" ] }, "reaction_10479557": { "compartment": "compartment_70101", "id": "reaction_10479557", "reactome": "R-DME-6784765", "name": "p-Y705-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718" ], "products": [ "species_10457720" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10479555": { "compartment": "compartment_70101", "id": "reaction_10479555", "reactome": "R-DME-6784763", "name": "p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457720" ], "products": [ "species_10457732" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10454317": { "compartment": "compartment_5460", "id": "reaction_10454317", "reactome": "R-DME-888548", "name": "ALDH5A1 dehydrogenates SUCCSA to SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_880046", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113536" ], "modifiers": [ [ "species_10454314", "catalyst" ] ], "additional_components": [ "Q9VBP6", "FBgn0039349" ] }, "reaction_10454932": { "compartment": "compartment_5460", "id": "reaction_10454932", "reactome": "R-DME-916855", "name": "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_916850", "species_113594" ], "products": [ "species_880046", "species_113552" ], "modifiers": [ [ "species_10454929", "catalyst" ] ], "additional_components": [ "Q9VW68", "FBgn0036927", "CHEBI:33739" ] }, "reaction_10457567": { "compartment": "compartment_7660", "id": "reaction_10457567", "reactome": "R-DME-997263", "name": "JMJD1C demethylates H3K9 mono- and di-methylation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457547" ], "products": [ "species_10457559" ], "modifiers": [ [ "species_10457564", "catalyst" ] ], "additional_components": [ "P02299", "FBgn0001199", "C0HL67", "FBgn0004828", "C0HL66", "FBgn0014857", "P02299", "FBgn0001199", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "FBgn0037703" ] }, "reaction_10457532": { "compartment": "compartment_7660", "id": "reaction_10457532", "reactome": "R-DME-996755", "name": "ZFPM proteins bind GATA proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457477", "species_10457528" ], "products": [ "species_10457530" ], "modifiers": [], "additional_components": [ "FBgn0003963", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "P52168", "FBgn0003117", "Q9VF00", "FBgn0038391", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "P52168", "FBgn0003117", "Q9VF00", "FBgn0038391", "Q9VPQ6", "FBgn0003963" ] }, "reaction_10457401": { "compartment": "compartment_70101", "id": "reaction_10457401", "reactome": "R-DME-992708", "name": "Dual-specific AKAPs bind type I and II PKA regulatory subunits", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434305", "species_10457397" ], "products": [ "species_10457399" ], "modifiers": [], "additional_components": [ "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243", "Q7KVW1", "FBgn0263987", "Q9V3I3", "FBgn0040079", "Q7KVW1", "FBgn0263987", "Q9V3I3", "FBgn0040079", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1", "P81900", "FBgn0022382", "P16905", "FBgn0259243" ] }, "reaction_10457385": { "compartment": "compartment_17906", "id": "reaction_10457385", "reactome": "R-DME-992703", "name": "Mitofusins trans-interact linking mitochondria prior to fusion", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457381" ], "products": [ "species_10457383" ], "modifiers": [], "additional_components": [ "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596" ] }, "reaction_10457432": { "compartment": "compartment_7660", "id": "reaction_10457432", "reactome": "R-DME-994106", "name": "HP1 alpha binds Histone H3K9(me)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457428", "species_10457406" ], "products": [ "species_10457430" ], "modifiers": [], "additional_components": [ "P02299", "FBgn0001199", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828", "FBgn0039019", "Q9VCU6", "FBgn0039019", "P02299", "FBgn0001199", "C0HL66", "FBgn0014857", "C0HL67", "FBgn0004828" ] }, "reaction_10457637": { "compartment": "compartment_70101", "id": "reaction_10457637", "reactome": "R-DME-1011598", "name": "DOCKs bind to RhoGEFs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457633", "species_10457631" ], "products": [ "species_10457635" ], "modifiers": [], "additional_components": [ "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "M9PCG3", "FBgn0260486", "Q9VPI9", "FBgn0031216", "M9PCG3", "FBgn0260486", "Q9VPI9", "FBgn0031216", "P40793", "FBgn0010341", "P40792", "RAC1_DROME" ] }, "reaction_10457604": { "compartment": "compartment_74700", "id": "reaction_10457604", "reactome": "R-DME-1011576", "name": "EHD proteins interact with Rabenosyn-5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457600", "species_10457591" ], "products": [ "species_10457602" ], "modifiers": [], "additional_components": [ "FBgn0261064", "FBgn0016693", "Q8T8W3", "FBgn0016693", "Q9VLS5", "FBgn0261064" ] }, "reaction_10457586": { "compartment": "compartment_5460", "id": "reaction_10457586", "reactome": "R-DME-1008248", "name": "Adenylate Kinase 3 is a GTP-AMP phosphotransferase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159448", "species_113573" ], "products": [ "species_113581", "species_113525" ], "modifiers": [ [ "species_10457583", "catalyst" ] ], "additional_components": [ "FBgn0042094" ] }, "reaction_10454176": { "compartment": "compartment_70101", "id": "reaction_10454176", "reactome": "R-DME-879459", "name": "F-actin capping protein is a heterodimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454167", "species_10454172" ], "products": [ "species_10454174" ], "modifiers": [], "additional_components": [ "FBgn0034577", "FBgn0011570", "P48603", "FBgn0011570", "Q9W2N0", "FBgn0034577" ] }, "reaction_10457472": { "compartment": "compartment_7660", "id": "reaction_10457472", "reactome": "R-DME-996727", "name": "REST recruits the BHC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457446", "species_10457468" ], "products": [ "species_10457470" ], "modifiers": [], "additional_components": [ "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q94517", "HDAC1", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397", "Q94517", "HDAC1", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397" ] }, "reaction_10457648": { "compartment": "compartment_74700", "id": "reaction_10457648", "reactome": "R-DME-1011600", "name": "Rabenosyn-5 connects Rab5 to VPS-45", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457600", "species_10457639", "species_10457644" ], "products": [ "species_10457646" ], "modifiers": [], "additional_components": [ "FBgn0261064", "FBgn0014010", "FBgn0261049", "Q9VHB5", "FBgn0261049", "Q9V3I2", "FBgn0014010", "Q9VLS5", "FBgn0261064" ] }, "reaction_10480078": { "compartment": "compartment_1222282", "id": "reaction_10480078", "reactome": "R-DME-6789126", "name": "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10480037", "catalyst" ] ], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_10480042": { "compartment": "compartment_21994", "id": "reaction_10480042", "reactome": "R-DME-6789031", "name": "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_6788973", "species_1470067" ], "products": [ "species_1222475", "species_6789150" ], "modifiers": [ [ "species_10480039", "catalyst" ] ], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_10489081": { "compartment": "compartment_984", "id": "reaction_10489081", "reactome": "R-DME-8855490", "name": "Lactoperoxidase (LPO) produces OSCN-", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351629", "species_8855492" ], "products": [ "species_109276", "species_8855489" ], "modifiers": [ [ "species_10489078", "catalyst" ] ], "additional_components": [ "Q9VZZ4", "FBgn0011828", "CHEBI:55376" ] }, "reaction_10491978": { "compartment": "compartment_1222282", "id": "reaction_10491978", "reactome": "R-DME-8933635", "name": "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1222719", "species_1470067", "species_6789221" ], "products": [ "species_8933637", "species_1222475" ], "modifiers": [ [ "species_10480037", "catalyst" ] ], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_10480080": { "compartment": "compartment_21994", "id": "reaction_10480080", "reactome": "R-DME-6789136", "name": "Myeloperoxidase (MPO) binds to the bacterial cell surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10480037", "species_983438" ], "products": [ "species_10480039" ], "modifiers": [], "additional_components": [ "CHEBI:55376", "Q9VZZ4", "FBgn0011828", "CHEBI:55376", "Q9VZZ4", "FBgn0011828" ] }, "reaction_209075": { "compartment": "compartment_876", "id": "reaction_209075", "reactome": "R-DME-209075", "name": "Destabilisation and degradation of AXN in the 'destruction complex'", "reversible": "false", "notes": "Axin (AXN) is now destabilised and is degraded by an unknown mechanism, possibly by a similar ubiquitin-mediated proteolysis responsible for cytoplasmic Armadillo (ARM) degradation.", "reactants": [ "species_206993" ], "products": [ "species_206837" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P54367", "CkIalpha", "O76324", "DCO", "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_209120": { "compartment": "compartment_70101", "id": "reaction_209120", "reactome": "R-DME-209120", "name": "Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR", "reversible": "false", "notes": "Phosphorylated Arrow (ARR) is recognised by Axin (AXN) which binds to it along with the rest of the 'destruction complex'. Dishevelled (DSH) is recruited to the cytoplasmic part of Frizzled (FZ/FZ2) and additionally forms an interaction with AXN. There is conjecture whether DSH first binds to AXN, helping to recruit it to the membrane, while the 'destruction complex' is free in the cytoplasm.", "reactants": [ "species_207028", "species_205749", "species_206613" ], "products": [ "species_206952" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm" ] }, "reaction_209081": { "compartment": "compartment_70101", "id": "reaction_209081", "reactome": "R-DME-209081", "name": "Disassembly of the destabilised 'destruction complex'", "reversible": "false", "notes": "The destabilised 'destruction complex' disassembles into the cytoplasm. The cytoplasmic concentration of Axin (AXN) has now decreased.", "reactants": [ "species_206837" ], "products": [ "species_206938", "species_205716", "species_206613", "species_205749", "species_206581", "species_205729", "species_206210" ], "modifiers": [], "additional_components": [ "P54367", "CkIalpha", "O76324", "DCO", "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC" ] }, "reaction_209112": { "compartment": "compartment_70101", "id": "reaction_209112", "reactome": "R-DME-209112", "name": "Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM", "reversible": "false", "notes": "The binding of Dishevelled (DSH) to Axin (AXN) in the 'destruction complex' appears to inhibit the kinase Shaggy (SGG). As this component appears to be the main instigator in keeping the 'destruction complex' phosphorylated, it's inactivation means the protein phosphatase orthologue, PP2A, can dephosphorylate members of the 'destruction complex'. This results in a decreased binding affinity for Armadillo (ARM) by AXN and APC (APC/APC2). The now unphosphorylated ARM disassociates from the 'destruction complex' into the cytoplasm.", "reactants": [ "species_206952" ], "products": [ "species_205774", "species_29372", "species_206993" ], "modifiers": [ [ "species_206612", "catalyst" ] ], "additional_components": [ "P51140", "phospho-dsh", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P54367", "CkIalpha", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "Q9V407", "phospho-Axn", "P18824", "arm", "P51140", "phospho-dsh", "P54367", "CkIalpha", "Q9V407", "phospho-Axn", "O76324", "DCO", "Q9Y1T2", "Apc2", "P91667", "Phospho (5 sites) APC", "P18431", "sgg", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws", "P18537", "FZ", "Q9VVX3", "FZ2", "P09615", "WG", "Q95V09", "ARR", "Q86BR9", "GISH", "P23696", "mts", "P36179", "Pp2A-29B", "P36872", "tws" ] }, "reaction_209297": { "compartment": "compartment_7660", "id": "reaction_209297", "reactome": "R-DME-209297", "name": "PYGO binds to the LGS:ARM complex", "reversible": "false", "notes": "The now nuclear Legless:Armadillo (LGS:ARM) complex binds to the nuclear anchor Pygopus (PYGO).", "reactants": [ "species_205990", "species_206839" ], "products": [ "species_206851" ], "modifiers": [], "additional_components": [ "Q961D9", "LGS", "P18824", "arm", "Q961D9", "LGS", "P18824", "arm", "Q9V9W8", "PYGO" ] }, "reaction_209181": { "compartment": "compartment_7660", "id": "reaction_209181", "reactome": "R-DME-209181", "name": "ARM displaces GRO and binds to PAN which activates transcription", "reversible": "false", "notes": "Armadillo (ARM) in its complex binds to Pangolin (PAN) and transcription is now activated.", "reactants": [ "species_206798", "species_206851" ], "products": [ "species_206729", "species_205750" ], "modifiers": [], "additional_components": [ "P91943", "PAN", "P16371", "GRO", "Q961D9", "LGS", "P18824", "arm", "Q9V9W8", "PYGO", "Q961D9", "LGS", "P18824", "arm", "Q9V9W8", "PYGO", "P91943", "PAN" ] }, "reaction_10428700": { "compartment": "compartment_70101", "id": "reaction_10428700", "reactome": "R-DME-71164", "name": "homogentisate + O2 => maleylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_30337" ], "products": [ "species_31135" ], "modifiers": [ [ "species_10428697", "catalyst" ] ], "additional_components": [ "Q9VKJ0", "FBgn0040211", "species_111793" ] }, "reaction_10428678": { "compartment": "compartment_70101", "id": "reaction_10428678", "reactome": "R-DME-71155", "name": "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_29506" ], "products": [ "species_29404", "species_31365" ], "modifiers": [ [ "species_10428675", "catalyst" ] ], "additional_components": [ "Q9VY42", "FBgn0030558" ] }, "reaction_10428710": { "compartment": "compartment_70101", "id": "reaction_10428710", "reactome": "R-DME-71173", "name": "maleylacetoacetate => fumarylacetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31135" ], "products": [ "species_31175" ], "modifiers": [ [ "species_10428707", "catalyst" ] ], "additional_components": [ "species_29450", "Q9VHD2", "FBgn0037697" ] }, "reaction_10428690": { "compartment": "compartment_70101", "id": "reaction_10428690", "reactome": "R-DME-71163", "name": "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_31365" ], "products": [ "species_113528", "species_30337" ], "modifiers": [ [ "species_10428687", "catalyst" ] ], "additional_components": [ "species_351595", "Q9VPF3", "FBgn0036992", "species_111793" ] }, "reaction_10428720": { "compartment": "compartment_70101", "id": "reaction_10428720", "reactome": "R-DME-71181", "name": "fumarylacetoacetate => fumarate + acetoacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_31175" ], "products": [ "species_29666", "species_29586" ], "modifiers": [ [ "species_10428717", "catalyst" ] ], "additional_components": [ "Q9VZI8", "FBgn0016013" ] }, "reaction_10479117": { "compartment": "compartment_70101", "id": "reaction_10479117", "reactome": "R-DME-5696365", "name": "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5696361", "species_29356" ], "products": [ "species_29502", "species_29448", "species_5359061" ], "modifiers": [ [ "species_10479114", "catalyst" ] ], "additional_components": [ "Q9VXT7", "FBgn0030653" ] }, "reaction_10454396": { "compartment": "compartment_70101", "id": "reaction_10454396", "reactome": "R-DME-893593", "name": "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29502", "species_29398" ], "products": [ "species_29432", "species_893599" ], "modifiers": [ [ "species_10454393", "catalyst" ] ], "additional_components": [ "Q8SXC2", "FBgn0037955" ] }, "reaction_10428667": { "compartment": "compartment_70101", "id": "reaction_10428667", "reactome": "R-DME-71146", "name": "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71112" ], "products": [ "species_29356", "species_71129" ], "modifiers": [ [ "species_10428664", "catalyst" ] ], "additional_components": [ "O76454", "FBgn0024841" ] }, "reaction_10428647": { "compartment": "compartment_70101", "id": "reaction_10428647", "reactome": "R-DME-71118", "name": "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29502", "species_29368" ], "products": [ "species_71112", "species_29506" ], "modifiers": [ [ "species_10428644", "catalyst" ] ], "additional_components": [ "species_111793", "P17276", "FBgn0001208" ] }, "reaction_10428657": { "compartment": "compartment_70101", "id": "reaction_10428657", "reactome": "R-DME-71130", "name": "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71129", "species_73473" ], "products": [ "species_29870", "species_29360" ], "modifiers": [ [ "species_10428654", "catalyst" ] ], "additional_components": [ "Q9VSU6", "FBgn0035964" ] }, "reaction_10426910": { "compartment": "compartment_7660", "id": "reaction_10426910", "reactome": "R-DME-68611", "name": "Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426899", "species_10426906" ], "products": [ "species_10426908" ], "modifiers": [], "additional_components": [ "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181", "FBgn0286788", "O16810", "FBgn0286788", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181" ] }, "reaction_10426892": { "compartment": "compartment_7660", "id": "reaction_10426892", "reactome": "R-DME-68603", "name": "Orc5 associates with Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426881", "species_10426888" ], "products": [ "species_10426890" ], "modifiers": [], "additional_components": [ "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "FBgn0015271", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654" ] }, "reaction_10426919": { "compartment": "compartment_7660", "id": "reaction_10426919", "reactome": "R-DME-68615", "name": "Orc6 associates with Orc1:Orc4:Orc5:Orc3:Orc2:origin complexes, forming ORC:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426915", "species_10426908" ], "products": [ "species_10426917" ], "modifiers": [], "additional_components": [ "FBgn0023180", "O16810", "FBgn0286788", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181", "Q24168", "FBgn0015270", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181" ] }, "reaction_10426901": { "compartment": "compartment_7660", "id": "reaction_10426901", "reactome": "R-DME-68610", "name": "Orc4 associates with Orc5:Orc3:Orc2:origin complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426897", "species_10426890" ], "products": [ "species_10426899" ], "modifiers": [], "additional_components": [ "FBgn0023181", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654", "Q9W102", "FBgn0023181" ] }, "reaction_10426883": { "compartment": "compartment_7660", "id": "reaction_10426883", "reactome": "R-DME-68595", "name": "Orc3 associates with Orc2 constitutively bound at origins of replication", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426872", "species_10426879" ], "products": [ "species_10426881" ], "modifiers": [], "additional_components": [ "FBgn0005654", "Q24168", "FBgn0015270", "Q24168", "FBgn0015270", "Q7K2L1", "FBgn0005654" ] }, "reaction_10432475": { "compartment": "compartment_7660", "id": "reaction_10432475", "reactome": "R-DME-75866", "name": "Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432463" ], "products": [ "species_10432471" ], "modifiers": [], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10432473": { "compartment": "compartment_7660", "id": "reaction_10432473", "reactome": "R-DME-75864", "name": "Newly Formed Phosphodiester Bond Stabilized and PPi Released", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432471" ], "products": [ "species_10431434", "species_113541" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10432465": { "compartment": "compartment_7660", "id": "reaction_10432465", "reactome": "R-DME-75861", "name": "NTP Binds Active Site of RNA Polymerase II", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432459", "species_30595" ], "products": [ "species_10432463" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10437548": { "compartment": "compartment_5460", "id": "reaction_10437548", "reactome": "R-DME-169270", "name": "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10437537" ], "products": [ "species_76633", "species_10437535" ], "modifiers": [ [ "species_10437545", "catalyst" ] ], "additional_components": [ "species_31649", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "species_113596", "FBgn0286783" ] }, "reaction_10436779": { "compartment": "compartment_70616", "id": "reaction_10436779", "reactome": "R-DME-164651", "name": "Electron transfer from ubiquinol to cytochrome c of complex III", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_10436150", "species_113529", "species_76633" ], "products": [ "species_73663", "species_10436148", "species_76633", "species_163953" ], "modifiers": [ [ "species_10436776", "catalyst" ] ], "additional_components": [ "CHEBI:38574", "P84029", "FBgn0284248", "CHEBI:38573", "P84029", "FBgn0284248", "Q9VRL0", "FBgn0035600", "Q9VFF0", "FBgn0038271", "Q9VXI6", "FBgn0030733", "Q9VQ29", "FBgn0021906", "Q9VVH5", "FBgn0036728", "A8Y535", "FBgn0260008", "P18935", "FBgn0013678", "Q9XY35", "FBgn0011227", "Q9VV75", "FBgn0250814" ] }, "reaction_10437540": { "compartment": "compartment_5460", "id": "reaction_10437540", "reactome": "R-DME-169260", "name": "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31649", "species_10437535" ], "products": [ "species_10437537", "species_113596" ], "modifiers": [ [ "species_10437535", "catalyst" ] ], "additional_components": [ "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "species_113596", "species_31649", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "Q0KHZ6", "FBgn0039697", "Q7KN94", "FBgn0010516", "species_76577", "species_113596" ] }, "reaction_10436576": { "compartment": "compartment_70616", "id": "reaction_10436576", "reactome": "R-DME-163217", "name": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_113529", "species_29362" ], "products": [ "species_76633", "species_113526", "species_163953" ], "modifiers": [ [ "species_10436566", "catalyst" ], [ "species_10436572", "catalyst" ] ], "additional_components": [ "Q9VMU0", "FBgn0031684", "Q9VMI3", "FBgn0031771", "species_76629", "Q9VWI0", "FBgn0031021", "Q94511", "FBgn0017566", "Q9VQD7", "FBgn0031436", "Q9VX36", "FBgn0030853", "P18931", "FBgn0262952", "P18932", "FBgn0013684", "P18933", "FBgn0013685", "P03896", "FBgn0013680", "Q9W2M9", "FBgn0034578", "Q059A4", "FBgn0033808", "P18930", "FBgn0013681", "Q9VZU4", "FBgn0266582", "Q9VF27", "FBgn0017567", "Q9V4E0", "FBgn0039909", "Q9VXK7", "FBgn0030718", "Q9VPE2", "FBgn0037001", "species_113596", "A8DYC4", "FBgn0085468", "Q7PL91", "FBgn0058002", "P91929", "FBgn0019957", "Q9VJZ4", "FBgn0032511", "Q94519", "FBgn0011361", "Q9W3X7", "FBgn0029888", "Q9V3L7", "FBgn0027785", "Q9W125", "FBgn0035046", "Q9VXZ0", "FBgn0030605", "Q7JYH3", "FBgn0034576", "O97418", "FBgn0025839", "Q9VTU2", "FBgn0011455", "Q9W402", "FBgn0029868", "Q7JZK1", "FBgn0033570", "Q6IDF5", "FBgn0033961", "Q9VQM2", "FBgn0031505", "Q9VTB4", "FBgn0047038", "Q9VR00", "FBgn0040705", "Q9W2E8", "FBgn0034645", "Q9W3N7", "FBgn0029971", "Q9VQR2", "FBgn0021967", "P18929", "FBgn0013679", "FBgn0033086" ] }, "reaction_10440271": { "compartment": "compartment_70101", "id": "reaction_10440271", "reactome": "R-DME-193073", "name": "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176626", "species_29360" ], "products": [ "species_70106", "species_193079", "species_73473" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10440269": { "compartment": "compartment_70101", "id": "reaction_10440269", "reactome": "R-DME-193064", "name": "HSD17B3-like proteins reducde ANDST to TEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193079", "species_29364" ], "products": [ "species_29366", "species_193057" ], "modifiers": [ [ "species_10440264", "catalyst" ] ], "additional_components": [ "FBgn0029975" ] }, "reaction_10498692": { "compartment": "compartment_70101", "id": "reaction_10498692", "reactome": "R-DME-9705714", "name": "SRD5A3 dehydrogenates TEST to DHTEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193057" ], "products": [ "species_469662", "species_29366" ], "modifiers": [ [ "species_10469802", "catalyst" ] ], "additional_components": [ "FBgn0032014" ] }, "reaction_10443612": { "compartment": "compartment_876", "id": "reaction_10443612", "reactome": "R-DME-265177", "name": "Exocyst complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443603", "species_10443588", "species_10443573", "species_10443608", "species_10443593", "species_10443578", "species_10443598", "species_10443583" ], "products": [ "species_10443610" ], "modifiers": [], "additional_components": [ "FBgn0266671", "FBgn0266674", "FBgn0266672", "FBgn0266667", "FBgn0266668", "FBgn0266670", "FBgn0266669", "FBgn0266673", "Q9XTM1", "FBgn0266673", "Q9VVG4", "FBgn0266669", "Q9VQQ9", "FBgn0266670", "Q7KRZ3", "FBgn0266668", "Q9VSJ8", "FBgn0266667", "Q9VNH6", "FBgn0266672", "Q9VDE6", "FBgn0266674", "Q9V8K2", "FBgn0266671" ] }, "reaction_10490116": { "compartment": "compartment_70101", "id": "reaction_10490116", "reactome": "R-DME-8867667", "name": "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399" ], "products": [ "species_8868400" ], "modifiers": [ [ "species_10490113", "catalyst" ] ], "additional_components": [ "FBgn0033463" ] }, "reaction_10490199": { "compartment": "compartment_70101", "id": "reaction_10490199", "reactome": "R-DME-8868402", "name": "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8868399", "species_1806217" ], "products": [ "species_8868393", "species_1806234" ], "modifiers": [ [ "species_10448907", "catalyst" ] ], "additional_components": [ "FBgn0020626" ] }, "reaction_10440382": { "compartment": "compartment_70101", "id": "reaction_10440382", "reactome": "R-DME-193766", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10440366": { "compartment": "compartment_70101", "id": "reaction_10440366", "reactome": "R-DME-193711", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10435762", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10440380": { "compartment": "compartment_17951", "id": "reaction_10440380", "reactome": "R-DME-193763", "name": "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193793" ], "products": [ "species_193422" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440378": { "compartment": "compartment_70101", "id": "reaction_10440378", "reactome": "R-DME-193758", "name": "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193760" ], "products": [ "species_29366", "species_213285" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440376": { "compartment": "compartment_70101", "id": "reaction_10440376", "reactome": "R-DME-193755", "name": "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_193745" ], "products": [ "species_193707", "species_29366" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440374": { "compartment": "compartment_70101", "id": "reaction_10440374", "reactome": "R-DME-193746", "name": "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193724", "species_70106", "species_29364" ], "products": [ "species_29366", "species_193760" ], "modifiers": [ [ "species_10440085", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10440372": { "compartment": "compartment_70101", "id": "reaction_10440372", "reactome": "R-DME-193743", "name": "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193778" ], "products": [ "species_111294", "species_29356", "species_193739", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10440386": { "compartment": "compartment_70101", "id": "reaction_10440386", "reactome": "R-DME-193789", "name": "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192189", "species_29360" ], "products": [ "species_193724", "species_70106", "species_73473" ], "modifiers": [ [ "species_10440112", "catalyst" ] ], "additional_components": [ "FBgn0036698" ] }, "reaction_10440370": { "compartment": "compartment_17951", "id": "reaction_10440370", "reactome": "R-DME-193736", "name": "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193732" ], "products": [ "species_193732" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10440384": { "compartment": "compartment_70101", "id": "reaction_10440384", "reactome": "R-DME-193781", "name": "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_193707", "species_29364" ], "products": [ "species_29366", "species_193728" ], "modifiers": [ [ "species_10440094", "catalyst" ] ], "additional_components": [ "Q9VTL0", "FBgn0036183", "M9PF61", "FBgn0086254" ] }, "reaction_10440368": { "compartment": "compartment_70101", "id": "reaction_10440368", "reactome": "R-DME-193727", "name": "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_76194", "species_193762" ], "products": [ "species_111294", "species_193741", "species_29356", "species_76577" ], "modifiers": [ [ "species_10440283", "catalyst" ] ], "additional_components": [ "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828" ] }, "reaction_10457738": { "compartment": "compartment_70101", "id": "reaction_10457738", "reactome": "R-DME-1168373", "name": "PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_10434957", "species_74016" ], "products": [ "species_10434971" ], "modifiers": [], "additional_components": [ "P13677", "FBgn0004784", "P05130", "FBgn0003091", "species_114519", "P13677", "FBgn0004784", "P05130", "FBgn0003091", "species_33625", "species_74016" ] }, "reaction_10457781": { "compartment": "compartment_70101", "id": "reaction_10457781", "reactome": "R-DME-1168633", "name": "NF-kappaB translocates from the cytosol to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457765" ], "products": [ "species_10457779" ], "modifiers": [], "additional_components": [ "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel" ] }, "reaction_10457811": { "compartment": "compartment_70101", "id": "reaction_10457811", "reactome": "R-DME-1168640", "name": "Ubiquitinated IkB is degraded", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457809" ], "products": [ "species_10457765" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q03017", "phospho-cact", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q94527", "Rel", "P98149", "Dif", "P15330", "dl", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10464584": { "compartment": "compartment_876", "id": "reaction_10464584", "reactome": "R-DME-2045911", "name": "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_179838" ], "modifiers": [ [ "species_10464581", "catalyst" ] ], "additional_components": [ "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q9VFI0", "FBgn0020299" ] }, "reaction_10457751": { "compartment": "compartment_12045", "id": "reaction_10457751", "reactome": "R-DME-1168376", "name": "STIM1 oligomerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457744" ], "products": [ "species_10457746", "species_74016" ], "modifiers": [ [ "species_10457748", "catalyst" ] ], "additional_components": [ "P83094", "Stim", "species_74016", "P83094", "Stim", "species_114520", "P29993", "FBgn0010051" ] }, "reaction_10464790": { "compartment": "compartment_876", "id": "reaction_10464790", "reactome": "R-DME-2076220", "name": "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_179838" ], "modifiers": [ [ "species_10464787", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q08012", "FBgn0004638" ] }, "reaction_10464848": { "compartment": "compartment_12045", "id": "reaction_10464848", "reactome": "R-DME-2089927", "name": "STIM1 binds TRPC1 forming STIM1:TRPC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457746", "species_10464844" ], "products": [ "species_10464846" ], "modifiers": [], "additional_components": [ "P83094", "Stim", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861", "P83094", "Stim" ] }, "reaction_10458693": { "compartment": "compartment_876", "id": "reaction_10458693", "reactome": "R-DME-1296045", "name": "Activation of Potassium transport channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458690", "catalyst" ] ], "additional_components": [ "B7YZX2", "FBgn0032706" ] }, "reaction_10458898": { "compartment": "compartment_876", "id": "reaction_10458898", "reactome": "R-DME-1299359", "name": "Activation of TALK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29804" ], "products": [ "species_74126" ], "modifiers": [ [ "species_10458895", "catalyst" ] ], "additional_components": [ "Q94526", "FBgn0017561" ] }, "reaction_10456991": { "compartment": "compartment_17957", "id": "reaction_10456991", "reactome": "R-DME-983144", "name": "Transport of Antigen peptide in to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_983032" ], "products": [ "species_29372", "species_29370", "species_983034" ], "modifiers": [ [ "species_10456988", "catalyst" ] ], "additional_components": [ "Q9VRW2", "FBgn0035695", "Q5BI62", "FBgn0010241", "Q00748", "FBgn0004513", "Q00449", "FBgn0004512" ] }, "reaction_10457141": { "compartment": "compartment_17957", "id": "reaction_10457141", "reactome": "R-DME-983158", "name": "Trimming of peptides in ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_983034" ], "products": [ "species_8943716", "species_983033" ], "modifiers": [ [ "species_10457138", "catalyst" ] ], "additional_components": [ "Q9VJN2", "FBgn0028935", "Q0KI25", "FBgn0039064", "Q9VD87", "FBgn0038897", "Q0KI00", "FBgn0263236", "Q9VAM2", "FBgn0039656", "Q9W2S8", "FBgn0030222", "Q95SR0", "FBgn0051445", "Q9W2S7", "FBgn0030223", "Q8SWX4", "FBgn0051343", "Q9W1S1", "FBgn0046253", "Q8MRN5", "FBgn0051343", "Q9VTL4", "FBgn0036186", "Q8IRH1", "FBgn0261243" ] }, "reaction_10433208": { "compartment": "compartment_5460", "id": "reaction_10433208", "reactome": "R-DME-77327", "name": "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77326", "species_113596" ], "products": [ "species_77324", "species_31649" ], "modifiers": [ [ "species_10433199", "catalyst" ] ], "additional_components": [ "Q9VDT1", "FBgn0038742" ] }, "reaction_10433206": { "compartment": "compartment_5460", "id": "reaction_10433206", "reactome": "R-DME-77325", "name": "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77324", "species_113521" ], "products": [ "species_77322" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433204": { "compartment": "compartment_5460", "id": "reaction_10433204", "reactome": "R-DME-77321", "name": "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77320" ], "products": [ "species_77318", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433212": { "compartment": "compartment_5460", "id": "reaction_10433212", "reactome": "R-DME-77333", "name": "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77332", "species_113521" ], "products": [ "species_77330" ], "modifiers": [ [ "species_10428444", "catalyst" ] ], "additional_components": [ "Q7JR58", "FBgn0033879" ] }, "reaction_10433210": { "compartment": "compartment_5460", "id": "reaction_10433210", "reactome": "R-DME-77329", "name": "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77328" ], "products": [ "species_77326", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433222": { "compartment": "compartment_5460", "id": "reaction_10433222", "reactome": "R-DME-77338", "name": "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_77337" ], "products": [ "species_77332", "species_31649" ], "modifiers": [ [ "species_10433219", "catalyst" ] ], "additional_components": [ "Q9VSA3", "FBgn0035811" ] }, "reaction_10433166": { "compartment": "compartment_5460", "id": "reaction_10433166", "reactome": "R-DME-77271", "name": "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_77269" ], "products": [ "species_77261", "species_113559" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433172": { "compartment": "compartment_5460", "id": "reaction_10433172", "reactome": "R-DME-77283", "name": "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77276", "species_113526" ], "products": [ "species_113529", "species_77269", "species_29362" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_10433169": { "compartment": "compartment_5460", "id": "reaction_10433169", "reactome": "R-DME-77277", "name": "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_77273", "species_113521" ], "products": [ "species_77276" ], "modifiers": [ [ "species_10433163", "catalyst" ] ], "additional_components": [ "Q9W1H8", "FBgn0025352", "Q9V397", "FBgn0028479" ] }, "reaction_210662": { "compartment": "compartment_70101", "id": "reaction_210662", "reactome": "R-DME-210662", "name": "Phosphorylated HOP is dephosphorylated by PTP61F isoform 1", "reversible": "false", "notes": "The Janus tyrosine kinase, Hopscotch (HOP) is dephosphorylated in the cytosol by the protein tyrosine phosphatase, PTP61F isoform 1.", "reactants": [ "species_206905" ], "products": [ "species_29372", "species_206753" ], "modifiers": [ [ "species_210628", "catalyst" ] ], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_210646": { "compartment": "compartment_70101", "id": "reaction_210646", "reactome": "R-DME-210646", "name": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 1", "reversible": "false", "notes": "In the cytosol, phosphorylated STAT92E dimer is dephosphorylated on Tyr711 by the protein tyrosine phosphatase, PTP61F isoform 1.", "reactants": [ "species_207008" ], "products": [ "species_205965", "species_29372" ], "modifiers": [ [ "species_210628", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_210694": { "compartment": "compartment_7660", "id": "reaction_210694", "reactome": "R-DME-210694", "name": "Phosphorylated STAT92E dimer is dephosphorylated by PTP61F isoform 2", "reversible": "false", "notes": "An alternative spliced form of the protein tyrosine phosphatase, PTP61FC (PTP61F isoform 2) is active in the nucleus and dephosphorylates the phosphorylated STAT92E dimer on Tyr711 resulting in its dissociation.", "reactants": [ "species_207031" ], "products": [ "species_113550", "species_206244" ], "modifiers": [ [ "species_210622", "catalyst" ] ], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_210687": { "compartment": "compartment_13231", "id": "reaction_210687", "reactome": "R-DME-210687", "name": "STAT92E transports from the nucleus to the cytosol", "reversible": "false", "notes": "Unphosphorylated STAT92E translocates from the nucleus to the cytosol.", "reactants": [ "species_206244" ], "products": [ "species_205965" ], "modifiers": [], "additional_components": [] }, "reaction_209307": { "compartment": "compartment_7660", "id": "reaction_209307", "reactome": "R-DME-209307", "name": "Phosphorylated STAT92E dimer activates transcription", "reversible": "false", "notes": "Once in the nucleus, the phosphorylated STAT92E dimer binds to a palindromic DNA sequence in the promoters of the pathway target genes. This now enables transcription to be activated.", "reactants": [ "species_207031" ], "products": [ "species_207031" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_209255": { "compartment": "compartment_984", "id": "reaction_209255", "reactome": "R-DME-209255", "name": "UPD ligand binds to the HOP:DOME:DOME:HOP complex and activates HOP", "reversible": "false", "notes": "The UPD (OS, UPD2, UPD3) family of ligands bind to the DOME:HOP dimer complex. Ligand binding suggests an induced conformational change in the DOME receptor that brings the HOP proteins, bound to the intracellular domains, closer together. The HOP tyrosine kinase is now activated.", "reactants": [ "species_206971", "species_206555" ], "products": [ "species_206753" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q9VWE0", "dome", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209336": { "compartment": "compartment_70101", "id": "reaction_209336", "reactome": "R-DME-209336", "name": "Activated HOP is autophosphorylated and/or transphosphorylated", "reversible": "false", "notes": "The activated HOPs phosphorylate themselves and each other. The precise residue position where this takes place is currently unknown as there are many potential phosphorylation sites on HOP.", "reactants": [ "species_113592", "species_206753" ], "products": [ "species_29370", "species_206905" ], "modifiers": [ [ "species_206753", "catalyst" ] ], "additional_components": [ "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209160": { "compartment": "compartment_70101", "id": "reaction_209160", "reactome": "R-DME-209160", "name": "Phosphorylated HOP phosphorylates DOME", "reversible": "false", "notes": "Tyr966 on the cytoplasmic tail of the DOME receptor is phosphorylated by phosphorylated HOP.", "reactants": [ "species_206905", "species_113592" ], "products": [ "species_206942", "species_29370" ], "modifiers": [ [ "species_206905", "catalyst" ] ], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome" ] }, "reaction_209231": { "compartment": "compartment_876", "id": "reaction_209231", "reactome": "R-DME-209231", "name": "DOME:HOP complex forms a dimer at the plasma membrane", "reversible": "false", "notes": "The HOP:DOME:DOME:HOP complex formation precedes ligand binding", "reactants": [ "species_206890" ], "products": [ "species_206971" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209245": { "compartment": "compartment_70101", "id": "reaction_209245", "reactome": "R-DME-209245", "name": "Tyrosine kinase Hopscotch (HOP) binds to the transmembrane cytokine receptor Domeless (DOME) to form the HOP:DOME complex", "reversible": "false", "notes": "The Domeless (DOME) cytokine receptor contains no tyrosine kinase domain. However, it is constitutively associated with the JAK tyrosine kinase, Hopscotch (HOP).", "reactants": [ "species_206172", "species_206271" ], "products": [ "species_206890" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q9VWE0", "dome" ] }, "reaction_209296": { "compartment": "compartment_7660", "id": "reaction_209296", "reactome": "R-DME-209296", "name": "SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription", "reversible": "false", "notes": "The negative pathway regulator SU(VAR)2-10 physically interacts with the phosphorylated STAT92E dimer and prevents it from binding to it's pathway target genes and so inhibiting transcription.SU(VAR)2-10 is a PIAS protein (protein inhibitors of activated STAT) and is also referred to as ZIMP protein.In vertebrates, PIAS proteins control the duration of JAK/STAT signalling by targeting active STAT for degradation by SUMOlation.", "reactants": [ "species_205759", "species_207031" ], "products": [ "species_206936" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E", "Q7KNF5", "SU(VAR)2-10" ] }, "reaction_210700": { "compartment": "compartment_7660", "id": "reaction_210700", "reactome": "R-DME-210700", "name": "KEN dimer represses transcription", "reversible": "false", "notes": "In the nucleus, the BCL6 orthologue, Ken and Barbie (KEN) dimer binds to GAAA sequences of the target gene DNA sequence. These overlap with some STAT92E binding sites and leads to transcription repression.", "reactants": [ "species_210679" ], "products": [ "species_210679" ], "modifiers": [], "additional_components": [ "O77459", "KEN", "O77459", "KEN" ] }, "reaction_209361": { "compartment": "compartment_70101", "id": "reaction_209361", "reactome": "R-DME-209361", "name": "STAT92E binds to phosphorylated HOP and phosphorylated DOME", "reversible": "false", "notes": "The phosphorylated residues on HOP and DOME form a docking site for the SH2 domains of STAT92E molecules and so a complex is formed involving these domains.", "reactants": [ "species_205965", "species_206942" ], "products": [ "species_206838" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E" ] }, "reaction_209365": { "compartment": "compartment_13231", "id": "reaction_209365", "reactome": "R-DME-209365", "name": "Phosphorylated STAT92E dimer transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated STAT92E dimer is translocated to the nucleus.", "reactants": [ "species_207008" ], "products": [ "species_207031" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_209210": { "compartment": "compartment_70101", "id": "reaction_209210", "reactome": "R-DME-209210", "name": "STAT92E is phosphorylated by phosphorylated HOP", "reversible": "false", "notes": "Tyr711 on STAT92E is phosphorylated by phosphorylated HOP tyrosine kinase.", "reactants": [ "species_113592", "species_206838" ], "products": [ "species_29370", "species_206806" ], "modifiers": [ [ "species_206838", "catalyst" ] ], "additional_components": [ "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E", "Q24592", "phospho-hop", "Q24151", "Stat92E", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E" ] }, "reaction_209321": { "compartment": "compartment_70101", "id": "reaction_209321", "reactome": "R-DME-209321", "name": "Phosphorylated STAT92E dissociates from HOP and DOME and dimerises", "reversible": "false", "notes": "After STAT92E is phosphorylated, it dissociates from phosphorylated HOP and phosphorylated DOME or the receptor complex. The now free phosphorylated STAT92E forms a dimer with another phosphorylated STAT92E molecule. These dimers are stabilised by the interaction between the SH2 domain of one molecule and the phospho Tyr of the other.", "reactants": [ "species_206806" ], "products": [ "species_206942", "species_207008" ], "modifiers": [], "additional_components": [ "Q24592", "phospho-hop", "Q24151", "Stat92E", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24592", "phospho-hop", "Q59E38", "UPD3", "Q9VWX2", "UPD2", "O96525", "OS", "Q9VWE0", "dome", "Q24151", "Stat92E" ] }, "reaction_10446644": { "compartment": "compartment_70101", "id": "reaction_10446644", "reactome": "R-DME-390329", "name": "Dephosphorylation of AKT by PP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10440775" ], "products": [ "species_29372", "species_10446639" ], "modifiers": [ [ "species_10440527", "catalyst" ] ], "additional_components": [] }, "reaction_10491859": { "compartment": "compartment_70101", "id": "reaction_10491859", "reactome": "R-DME-8931974", "name": "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10435578" ], "products": [ "species_10491851", "species_71285" ], "modifiers": [ [ "species_10491856", "catalyst" ] ], "additional_components": [ "P08736", "FBgn0284245", "P05303", "FBgn0000557", "P05303", "FBgn0000557", "P08736", "FBgn0284245", "FBgn0031777" ] }, "reaction_10491942": { "compartment": "compartment_70101", "id": "reaction_10491942", "reactome": "R-DME-8932413", "name": "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10435578" ], "products": [ "species_10491934", "species_71285" ], "modifiers": [ [ "species_10491939", "catalyst" ] ], "additional_components": [ "P08736", "FBgn0284245", "P05303", "FBgn0000557", "P05303", "FBgn0000557", "P08736", "FBgn0284245", "FBgn0031485" ] }, "reaction_10491880": { "compartment": "compartment_70101", "id": "reaction_10491880", "reactome": "R-DME-8932276", "name": "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10471517" ], "products": [ "species_71285", "species_10491872" ], "modifiers": [ [ "species_10491877", "catalyst" ] ], "additional_components": [ "FBgn0286784", "FBgn0286784", "FBgn0031003" ] }, "reaction_10491839": { "compartment": "compartment_70101", "id": "reaction_10491839", "reactome": "R-DME-8879123", "name": "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_10430268" ], "products": [ "species_10491831", "species_71285" ], "modifiers": [ [ "species_10491836", "catalyst" ] ], "additional_components": [ "FBgn0004867", "FBgn0004867", "FBgn0038306" ] }, "reaction_10490208": { "compartment": "compartment_876", "id": "reaction_10490208", "reactome": "R-DME-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461036", "species_10490194" ], "products": [ "species_10490201" ], "modifiers": [], "additional_components": [ "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10490368": { "compartment": "compartment_876", "id": "reaction_10490368", "reactome": "R-DME-8868661", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490203" ], "products": [ "species_29372", "species_10490359" ], "modifiers": [ [ "species_10490203", "catalyst" ] ], "additional_components": [ "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", 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"FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", 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"O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "Q7KLE5", "FBgn0027356", "P27619", "FBgn0003392", "species_29438", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772" ] }, "reaction_10489506": { "compartment": "compartment_876", "id": "reaction_10489506", "reactome": "R-DME-8862280", "name": "FCHo proteins bind nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489326", "species_10489339", "species_10489337", "species_10489331", "species_10439052", "species_10442542" ], "products": [ "species_10489341" ], "modifiers": [], "additional_components": [ "Q6AWD5", "FBgn0037702", "FBgn0037702", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "FBgn0032341", "FBgn0035060", "FBgn0023388", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q6AWD5", "FBgn0037702" ] }, "reaction_10490921": { "compartment": "compartment_24339", "id": "reaction_10490921", "reactome": "R-DME-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490919" ], "products": [ "species_10489311", "species_10490404" ], "modifiers": [], "additional_components": [ "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9V3I2", "FBgn0014010", "Q9VZ08", "FBgn0030286", "FBgn0015772", "Q9V3I2", "FBgn0014010", "species_29438", "Q9VZ08", "FBgn0030286", "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702" ] }, "reaction_10490923": { "compartment": "compartment_24339", "id": "reaction_10490923", "reactome": "R-DME-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490917", "species_10490352" ], "products": [ "species_10490919" ], "modifiers": [], "additional_components": [ "Q9V3I2", "FBgn0014010", "species_29420", "Q9VZ08", "FBgn0030286", "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P27619", "FBgn0003392", "species_29420", "Q9VMY8", "FBgn0037218", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9V3I2", "FBgn0014010", "Q9VZ08", "FBgn0030286" ] }, "reaction_10490925": { "compartment": "compartment_876", "id": "reaction_10490925", "reactome": "R-DME-8871196", "name": "Initial binding of AP-2 and clathrin to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469475", "species_10447882", "species_179856" ], "products": [ "species_10489337" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012" ] }, "reaction_10489357": { "compartment": "compartment_876", "id": "reaction_10489357", "reactome": "R-DME-8856808", "name": "Recruitment of AP-2 complex and clathrin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489311", "species_10489341", "species_10469475", "species_10447882", "species_10489347" ], "products": [ "species_10489349" ], "modifiers": [ [ "species_10489355", "catalyst" ] ], "additional_components": [ "FBgn0015772", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q6AWD5", "FBgn0037702", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9VXB0", "FBgn0030791", "Q9VXB0", "FBgn0030791", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9VTX5", "FBgn0020655", "P40946", "FBgn0013750", "species_29438" ] }, "reaction_10490190": { "compartment": "compartment_876", "id": "reaction_10490190", "reactome": "R-DME-8868230", "name": "SNX9 recruits components of the actin polymerizing machinery", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490175", "species_10490171", "species_10490186", "species_10490184", "species_10469463", "species_10490179" ], "products": [ "species_10490188" ], "modifiers": [], "additional_components": [ "Q8MQJ8", "FBgn0036309", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "species_113592", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q8MQJ8", "FBgn0036309", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475" ] }, "reaction_10490130": { "compartment": "compartment_876", "id": "reaction_10490130", "reactome": "R-DME-8867756", "name": "CLASP proteins and cargo are recruited to the nascent clathrin-coated pit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490118", "species_10489365" ], "products": [ "species_10490120" ], "modifiers": [], "additional_components": [ "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10490196": { "compartment": "compartment_876", "id": "reaction_10490196", "reactome": "R-DME-8868236", "name": "BAR domain proteins recruit dynamin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490188", "species_10490192" ], "products": [ "species_10490194" ], "modifiers": [], "additional_components": [ "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "P27619", "FBgn0003392", "species_29438", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475" ] }, "reaction_10490133": { "compartment": "compartment_876", "id": "reaction_10490133", "reactome": "R-DME-8868066", "name": "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_179856" ], "modifiers": [ [ "species_10447052", "catalyst" ] ], "additional_components": [ "FBgn0034789" ] }, "reaction_10490357": { "compartment": "compartment_24339", "id": "reaction_10490357", "reactome": "R-DME-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490350", "species_29356" ], "products": [ "species_29372", "species_10490354", "species_10490352" ], "modifiers": [ [ "species_10490350", "catalyst" ] ], "additional_components": [ "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490120", "species_10461053" ], "products": [ "species_10490122" ], "modifiers": [], "additional_components": [ "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "FBgn0015278", "Q7K3H0", "FBgn0015278", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10489368": { "compartment": "compartment_876", "id": "reaction_10489368", "reactome": "R-DME-8856813", "name": "AAK1 phosphorylates AP-2 mu subunit at T156", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10489349" ], "products": [ "species_29370", "species_10489365" ], "modifiers": [ [ "species_10489349", "catalyst" ] ], "additional_components": [ "Q9VXB0", "FBgn0030791", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9VXB0", "FBgn0030791", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "M9ND00", "FBgn0023388", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "species_179856", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772" ] }, "reaction_10490138": { "compartment": "compartment_876", "id": "reaction_10490138", "reactome": "R-DME-8868072", "name": "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_392417" ], "products": [ "species_29370", "species_202247" ], "modifiers": [ [ "species_10490122", "catalyst" ] ], "additional_components": [ "Q7K3H0", "FBgn0015278", "M9ND00", "FBgn0023388", "species_179856", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VXB0", "FBgn0030791", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037" ] }, "reaction_10490363": { "compartment": "compartment_24339", "id": "reaction_10490363", "reactome": "R-DME-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490359", "species_10447997" ], "products": [ "species_10490361" ], "modifiers": [], "additional_components": [ "P27619", "FBgn0003392", "species_29420", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "FBgn0037218", "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q8MQJ8", "FBgn0036309", "Q9VMY8", "FBgn0037218", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9VJ30", "FBgn0015772" ] }, "reaction_10490365": { "compartment": "compartment_24339", "id": "reaction_10490365", "reactome": "R-DME-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471267", "species_10490361" ], "products": [ "species_10490350" ], "modifiers": [], "additional_components": [ "P11147", "FBgn0266599", "species_113592", "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q8MQJ8", "FBgn0036309", "Q9VMY8", "FBgn0037218", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9VJ30", "FBgn0015772", "P27619", "FBgn0003392", "species_29420", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "A8JNK4", "FBgn0035533", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "O17444", "FBgn0270928", "Q27367", "FBgn0015924", "A8JQU1", "FBgn0037386", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P51140", "phospho-dsh", "P16395", "FBgn0000037", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "A1Z9D7", "FBgn0000119", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "P98081", "FBgn0000414", "A8JTM7", "FBgn0261260", "Q5BIG2", "FBgn0036202", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q8MQJ8", "FBgn0036309", "Q9VMY8", "FBgn0037218", "Q9VXB0", "FBgn0030791", "species_392417", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "P11147", "FBgn0266599", "Q9VJ30", "FBgn0015772" ] }, "reaction_10490206": { "compartment": "compartment_876", "id": "reaction_10490206", "reactome": "R-DME-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10490201" ], "products": [ "species_29372", "species_10490203" ], "modifiers": [ [ "species_10490201", "catalyst" ] ], "additional_components": [ "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", 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"FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q8MQJ8", "FBgn0036309", "Q9VXB0", "FBgn0030791", "species_392417", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9W111", "FBgn0035060", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "Q8T390", "FBgn0038659", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8MQS4", "FBgn0032341", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q9VDF4", "FBgn0025865", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "A8JNK4", "FBgn0035533", "Q7KLE5", "FBgn0027356", "P27619", "FBgn0003392", "species_29438", "M9ND00", "FBgn0023388", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508", "Q9NCC3", "FBgn0040475", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "P27619", "FBgn0003392", "species_29438", "Q8MQJ8", "FBgn0036309", "P10987", "FBgn0000042", "P83967", "FBgn0000047", "P10981", "FBgn0000046", "P53501", "FBgn0000044", "P02574", "FBgn0000045", "P45891", "FBgn0011743", "species_113592", "Q9VDF4", "FBgn0025865", "Q9VIM5", "FBgn0032859", "Q9VQD8", "FBgn0031437", "P45888", "FBgn0011742", "O97182", "FBgn0001961", "Q9VMH2", "FBgn0284255", "P32392", "FBgn0262716", "Q9VF28", "FBgn0038369", "Q7KLE5", "FBgn0027356", "Q8T390", "FBgn0038659", "A8JNK4", "FBgn0035533", "M9ND00", "FBgn0023388", "species_179856", "Q9W111", "FBgn0035060", "Q8MQS4", "FBgn0032341", "Q9VXB0", "FBgn0030791", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VI75", "FBgn0086372", "Q24212", "FBgn0016975", "P21521", "FBgn0004242", "Q9VUJ3", "FBgn0261090", "A8JQU1", "FBgn0037386", "Q27367", "FBgn0015924", "O17444", "FBgn0270928", "Q9VSC9", "FBgn0035833", "Q9VGM1", "FBgn0263316", "Q7KT22", "FBgn0032908", "Q9VJ21", "FBgn0051793", "Q8MT77", "FBgn0051793", "Q9VLN6", "FBgn0032026", "Q961D3", "FBgn0039644", "Q9W2I5", "FBgn0034612", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "P91660", "FBgn0010549", "Q5BIG2", "FBgn0036202", "A8JTM7", "FBgn0261260", "P98081", "FBgn0000414", "E1JHR0", "FBgn0020304", "Q7JYX5", "FBgn0266186", "Q9VS85", "FBgn0028582", "Q08012", "FBgn0004638", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "P04412", "FBgn0003731", "Q9VSK2", "FBgn0020224", "A1Z9D7", "FBgn0000119", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P51140", "phospho-dsh", "P28466", "FBgn0010194", "Q9NBW1", "FBgn0027342", "O77438", "FBgn0027343", "P16395", "FBgn0000037", "Q6AWD5", "FBgn0037702", "Q9VJ30", "FBgn0015772", "Q9NCC3", "FBgn0040475", "Q5U0V7", "FBgn0034691", "O46094", "FBgn0023508" ] }, "reaction_10439917": { "compartment": "compartment_70101", "id": "reaction_10439917", "reactome": "R-DME-190829", "name": "Lysosomal degradation of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439913" ], "products": [], "modifiers": [], "additional_components": [ "P98081", "FBgn0000414", "O62530", "FBgn0263351", "Q01989", "FBgn0011225" ] }, "reaction_10439915": { "compartment": "compartment_876", "id": "reaction_10439915", "reactome": "R-DME-190519", "name": "Internalization of gap junction plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439857", "species_10439852" ], "products": [ "species_10439913" ], "modifiers": [], "additional_components": [ "FBgn0011225", "P98081", "FBgn0000414", "O62530", "FBgn0263351", "P98081", "FBgn0000414", "O62530", "FBgn0263351", "Q01989", "FBgn0011225" ] }, "reaction_10440628": { "compartment": "compartment_876", "id": "reaction_10440628", "reactome": "R-DME-196026", "name": "Dab2 is recruited to the junctional plaques", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439834", "species_10439839" ], "products": [ "species_10439841" ], "modifiers": [], "additional_components": [ "O62530", "FBgn0263351", "FBgn0000414", "P98081", "FBgn0000414", "O62530", "FBgn0263351" ] }, "reaction_10440626": { "compartment": "compartment_876", "id": "reaction_10440626", "reactome": "R-DME-196017", "name": "Dynamin is recruited to the gap junction plaque", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439841", "species_10439850" ], "products": [ "species_10439852" ], "modifiers": [], "additional_components": [ "P98081", "FBgn0000414", "O62530", "FBgn0263351", "P98081", "FBgn0000414", "O62530", "FBgn0263351" ] }, "reaction_10486354": { "compartment": "compartment_6791047", "id": "reaction_10486354", "reactome": "R-DME-6807866", "name": "GBF1 recruits ARF:GDP to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486350", "species_10486342" ], "products": [ "species_10486352" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29420", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10486755": { "compartment": "compartment_20699", "id": "reaction_10486755", "reactome": "R-DME-6809014", "name": "cis-Golgi cis-SNARE binds NSF and SNAPs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10486749", "species_10478727" ], "products": [ "species_10486753" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "Q9W3M8", "FBgn0260858", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9W3M8", "FBgn0260858", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "Q23983", "FBgn0250791" ] }, "reaction_10486564": { "compartment": "compartment_6791047", "id": "reaction_10486564", "reactome": "R-DME-6807877", "name": "ARFGAPs stimulate ARF GTPase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486475" ], "products": [ "species_10486350", "species_10486421", "species_10486340", "species_10486561" ], "modifiers": [ [ "species_10486475", "catalyst" ] ], "additional_components": [ "Q0KIE7", "FBgn0011747", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9W3M8", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "P40945", "FBgn0013749", "species_29420", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "FBgn0264560", "Q0KIE7", "FBgn0011747", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9W3N6", "FBgn0040087", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VVX6", "FBgn0260857", "O76767", "FBgn0267330", "Q9W3M8", "FBgn0260858", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q0KIE7", "FBgn0011747", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9W3M8", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789" ] }, "reaction_10486407": { "compartment": "compartment_6791047", "id": "reaction_10486407", "reactome": "R-DME-6807872", "name": "Active ARF recruits coatomer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486358", "species_10486403" ], "products": [ "species_10486405" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087" ] }, "reaction_10486344": { "compartment": "compartment_6791047", "id": "reaction_10486344", "reactome": "R-DME-6807864", "name": "RAB1:GTP recruits GBF1 to the ERGIC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478691", "species_10486340", "species_10486338" ], "products": [ "species_10486342" ], "modifiers": [], "additional_components": [ "Q9W3N6", "FBgn0040087", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087" ] }, "reaction_10486361": { "compartment": "compartment_6791047", "id": "reaction_10486361", "reactome": "R-DME-6807868", "name": "GBF1 stimulates ARF nucleotide exchange", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10486352" ], "products": [ "species_29370", "species_10486358" ], "modifiers": [ [ "species_10486352", "catalyst" ] ], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "P40945", "FBgn0013749", "species_29420", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10486587": { "compartment": "compartment_432051", "id": "reaction_10486587", "reactome": "R-DME-6809003", "name": "ERGIC-to-Golgi vesicles bind dynein:dynactin ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473488", "species_10486561" ], "products": [ "species_10486585" ], "modifiers": [], "additional_components": [ "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420", "Q0KIE7", "FBgn0011747", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9W3N6", "FBgn0040087", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VVX6", "FBgn0260857", "O76767", "FBgn0267330", "Q9W3M8", "FBgn0260858", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q0KIE7", "FBgn0011747", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9W3N6", "FBgn0040087", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VVX6", "FBgn0260857", "O76767", "FBgn0267330", "Q9W3M8", "FBgn0260858", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29420" ] }, "reaction_10486477": { "compartment": "compartment_6791047", "id": "reaction_10486477", "reactome": "R-DME-6807875", "name": "ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486473", "species_10478762", "species_10486421", "species_10486405", "species_10486467", "species_10486450", "species_10449902" ], "products": [ "species_10486475" ], "modifiers": [], "additional_components": [ "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "FBgn0011747", "Q0KIE7", "FBgn0011747", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9W3N6", "FBgn0040087", "Q9W3M8", "FBgn0260858", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789" ] }, "reaction_10486751": { "compartment": "compartment_20699", "id": "reaction_10486751", "reactome": "R-DME-6809011", "name": "cis-Golgi t-SNAREs bind YKT6 on tethered vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486730", "species_10486745" ], "products": [ "species_10486747" ], "modifiers": [], "additional_components": [ "Q9VMD2", "FBgn0031818", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "Q0KIE7", "FBgn0011747", "Q9W3M8", "FBgn0260858", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "O76767", "FBgn0267330", "Q9VVX6", "FBgn0260857", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W3N6", "FBgn0040087", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "Q9VRL2", "FBgn0260856", "Q24509", "FBgn0011708", "Q9VE50", "FBgn0044871", "Q9VVX6", "FBgn0260857", "Q9VMD2", "FBgn0031818", "Q9W289", "FBgn0034697", "Q9VW57", "FBgn0036919", "Q0KIE7", "FBgn0011747", "Q9W3M8", "FBgn0260858", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q00963", "FBgn0250788", "A8JNJ6", "FBgn0004167", "P13395", "FBgn0250789", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "Q9W3N6", "FBgn0040087", "Q961G1", "FBgn0031536", "Q9VAD6", "FBgn0051040", "Q95TN4", "FBgn0032258", "Q9VGC3", "FBgn0037998", "Q9VKH0", "FBgn0032361", "Q9VJD3", "FBgn0024689", "Q9VF78", "FBgn0026634", "Q9V564", "FBgn0033401" ] }, "reaction_10478860": { "compartment": "compartment_12045", "id": "reaction_10478860", "reactome": "R-DME-5694428", "name": "LMAN family proteins bind glycosylated cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478856", "species_10478844" ], "products": [ "species_10478858" ], "modifiers": [], "additional_components": [ "Q9V3A8", "FBgn0035909", "Q7JYA0", "FBgn0033873", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q7JYA0", "FBgn0033873", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3A8", "FBgn0035909" ] }, "reaction_10478888": { "compartment": "compartment_12045", "id": "reaction_10478888", "reactome": "R-DME-5694442", "name": "CNIH2,3 bind GRIA1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478884", "species_10478868" ], "products": [ "species_10478886" ], "modifiers": [], "additional_components": [ "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "FBgn0000339", "P49858", "FBgn0000339", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401" ] }, "reaction_10478866": { "compartment": "compartment_12045", "id": "reaction_10478866", "reactome": "R-DME-5694433", "name": "MIA2 binds PREB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442366", "species_10478862" ], "products": [ "species_10478864" ], "modifiers": [], "additional_components": [ "FBgn0031779", "FBgn0286898", "Q9VMH4", "FBgn0031779", "Q9VMA7", "FBgn0286898" ] }, "reaction_10488161": { "compartment": "compartment_20699", "id": "reaction_10488161", "reactome": "R-DME-8849348", "name": "RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488142", "species_10488157", "species_10488144" ], "products": [ "species_10488159" ], "modifiers": [], "additional_components": [ "O18334", "Rab6", "species_29438", "P16568", "FBgn0000183", "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438" ] }, "reaction_10488321": { "compartment": "compartment_12045", "id": "reaction_10488321", "reactome": "R-DME-8850040", "name": "RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488317", "species_10488198" ], "products": [ "species_10488319" ], "modifiers": [], "additional_components": [ "Q9W4A0", "FBgn0015794", "species_29420", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29420" ] }, "reaction_10488324": { "compartment": "compartment_12045", "id": "reaction_10488324", "reactome": "R-DME-8850041", "name": "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488319", "species_29438" ], "products": [ "species_29420", "species_10488204" ], "modifiers": [ [ "species_10488319", "catalyst" ] ], "additional_components": [ "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29420", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29438", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29420" ] }, "reaction_10487912": { "compartment": "compartment_20699", "id": "reaction_10487912", "reactome": "R-DME-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429785", "species_29356" ], "products": [ "species_6814303", "species_8848483" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10488138": { "compartment": "compartment_20699", "id": "reaction_10488138", "reactome": "R-DME-8849345", "name": "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_548819", "species_8848483" ], "products": [ "species_429785", "species_76194" ], "modifiers": [ [ "species_10488135", "catalyst" ] ], "additional_components": [ "D5AEK7", "FBgn0036623", "Q9VV49", "FBgn0036622" ] }, "reaction_10488172": { "compartment": "compartment_20699", "id": "reaction_10488172", "reactome": "R-DME-8849350", "name": "RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488159", "species_10488168" ], "products": [ "species_10488170", "species_10488166" ], "modifiers": [], "additional_components": [ "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "Q7KNS3", "FBgn0015754", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420", "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29420", "FBgn0015754" ] }, "reaction_10488206": { "compartment": "compartment_12045", "id": "reaction_10488206", "reactome": "R-DME-8849353", "name": "Dynein drives COPI-independent retrograde traffic from the Golgi to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488170", "species_113592" ], "products": [ "species_10473488", "species_10488157", "species_29370", "species_10488186" ], "modifiers": [ [ "species_10488204", "catalyst" ], [ "species_8848483", "catalyst" ] ], "additional_components": [ "Q6WV19", "FBgn0031530", "Q6WV17", "FBgn0031681", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29420", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420", "P16568", "FBgn0000183", "O18334", "Rab6", "species_29438", "Q6WV17", "FBgn0031681", "Q6WV19", "FBgn0031530", "Q9VKB9", "FBgn0027505", "Q9VQ26", "FBgn0051935", "Q9W4A0", "FBgn0015794", "species_29438" ] }, "reaction_10486977": { "compartment": "compartment_20699", "id": "reaction_10486977", "reactome": "R-DME-6811418", "name": "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486962" ], "products": [ "species_10486350", "species_10486974", "species_10486421", "species_10486340" ], "modifiers": [ [ "species_10486962", "catalyst" ] ], "additional_components": [ "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "M9PGI6", "FBgn0260855", "P40945", "FBgn0013749", "species_29420", "M9PGI6", "FBgn0260855", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "O76767", "FBgn0267330", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "FBgn0264560", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "M9PGI6", "FBgn0260855" ] }, "reaction_10487089": { "compartment": "compartment_12045", "id": "reaction_10487089", "reactome": "R-DME-6811427", "name": "COPI vesicle uncoating at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487087" ], "products": [ "species_10487085", "species_10487003", "species_10487051", "species_10478404", "species_10486403" ], "modifiers": [], "additional_components": [ "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "Q8I0G5", "FBgn0028968", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "Q9VYT6", "FBgn0030341", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "Q9VS46", "FBgn0035762", "Q9W4X9", "FBgn0004643", "O76767", "FBgn0267330", "O18405", "FBgn0019925", "O76767", "FBgn0267330", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "M9PGI6", "FBgn0260855", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "Q9VYT6", "FBgn0030341", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q8SXY6", "FBgn0045866", "Q9W4K0", "FBgn0029709", "species_29420", "O18332", "FBgn0285937", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496" ] }, "reaction_10486947": { "compartment": "compartment_20699", "id": "reaction_10486947", "reactome": "R-DME-6811412", "name": "Active ARF recruits coatomer to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486943", "species_10486403" ], "products": [ "species_10486945" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560" ] }, "reaction_10486964": { "compartment": "compartment_20699", "id": "reaction_10486964", "reactome": "R-DME-6811417", "name": "ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486954", "species_10486421", "species_10486708", "species_10486945", "species_10486960" ], "products": [ "species_10486962" ], "modifiers": [], "additional_components": [ "FBgn0260855", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "Q9VYT6", "FBgn0030341", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "O76767", "FBgn0267330", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "Q8I0G5", "FBgn0028968", "P45437", "FBgn0008635", "Q9W0B8", "FBgn0025725", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "Q9VYT6", "FBgn0030341", "Q9VTX5", "FBgn0020655", "A8JNX0", "FBgn0037182", "M9PGI6", "FBgn0260855" ] }, "reaction_10486950": { "compartment": "compartment_20699", "id": "reaction_10486950", "reactome": "R-DME-6811414", "name": "GBF1 stimulates nucleotide exchange on ARF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10486939" ], "products": [ "species_10486943", "species_29420" ], "modifiers": [ [ "species_10486939", "catalyst" ] ], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "P40945", "FBgn0013749", "species_29420", "P40945", "FBgn0013749", "species_29438", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "A1Z8W8", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10486999": { "compartment": "compartment_12045", "id": "reaction_10486999", "reactome": "R-DME-6811422", "name": "NSF ATPase activity dissociates cis-SNARE at the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10486996" ], "products": [ "species_10478736", "species_29372", "species_10486987", "species_10478727", "species_10486982", "species_10478669", "species_10486992" ], "modifiers": [ [ "species_10486996", "catalyst" ] ], "additional_components": [ "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791", "Q23983", "FBgn0250791", "FBgn0039212", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "FBgn0037383", "FBgn0260855", "FBgn0035965", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10486952": { "compartment": "compartment_20699", "id": "reaction_10486952", "reactome": "R-DME-6811415", "name": "RAB:GTP recruits GBF1 to the Golgi membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486678", "species_10486340" ], "products": [ "species_10486937" ], "modifiers": [], "additional_components": [ "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560" ] }, "reaction_10486941": { "compartment": "compartment_20699", "id": "reaction_10486941", "reactome": "R-DME-6811411", "name": "GBF1 recruits ARF:GDP to the Golgi", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486350", "species_10486937" ], "products": [ "species_10486939" ], "modifiers": [], "additional_components": [ "P40945", "FBgn0013749", "species_29420", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "species_29438", "A1Z8W8", "FBgn0264560", "P40945", "FBgn0013749", "species_29420" ] }, "reaction_10487005": { "compartment": "compartment_12045", "id": "reaction_10487005", "reactome": "R-DME-6811425", "name": "NSF and SNAPs bind cis-SNARE at the ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10487003", "species_10478727" ], "products": [ "species_10486996" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "M9PGI6", "FBgn0260855", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9VSU7", "FBgn0035965", "Q9VNI9", "FBgn0037383", "Q9VC58", "FBgn0039212", "M9PGI6", "FBgn0260855", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487007": { "compartment": "compartment_432051", "id": "reaction_10487007", "reactome": "R-DME-6811426", "name": "Retrograde COPI vesicles bind kinesin and microtubules", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486974", "species_10457347" ], "products": [ "species_10487001" ], "modifiers": [], "additional_components": [ "M9PGI6", "FBgn0260855", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "species_29438", "O76767", "FBgn0267330", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341", "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379", "species_29438", "species_29420", "Q9W1U4", "FBgn0034824", "Q9W1U1", "FBgn0034827", "Q960Z0", "FBgn0030268", "P46863", "FBgn0004378", "Q9VLW2", "FBgn0031955", "Q9VRK9", "FBgn0004380", "Q9VZ07", "FBgn0028421", "P46867", "FBgn0004381", "A1Z9I5", "FBgn0086356", "Q9VZF5", "FBgn0011692", "Q9VKI0", "FBgn0040232", "P46824", "FBgn0010235", "P17210", "FBgn0001308", "Q9XZ29", "FBgn0011606", "Q9VSW5", "FBgn0004379", "M9PGI6", "FBgn0260855", "O62621", "FBgn0025724", "Q9Y0Y5", "FBgn0027496", "Q9W0B8", "FBgn0025725", "Q8I0G5", "FBgn0028968", "Q9VV89", "FBgn0040512", "Q9W555", "FBgn0028969", "P45437", "FBgn0008635", "O18332", "FBgn0285937", "M9PE35", "FBgn0035155", "O76767", "FBgn0267330", "Q9W4K0", "FBgn0029709", "O18405", "FBgn0019925", "Q8SXY6", "FBgn0045866", "Q86BA5", "FBgn0053105", "Q9I7K5", "FBgn0069242", "Q9VYT6", "FBgn0030341" ] }, "reaction_10487616": { "compartment": "compartment_263163", "id": "reaction_10487616", "reactome": "R-DME-6814684", "name": "cis-SNARE binds SNAPs and NSF hexamer at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10487612", "species_10478727" ], "products": [ "species_10487614" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "Q9VR90", "FBgn0031106", "Q9W0N6", "FBgn0260862", "Q7JY00", "FBgn0037084", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q9VR90", "FBgn0031106", "Q9W0N6", "FBgn0260862", "Q7JY00", "FBgn0037084", "Q23983", "FBgn0250791" ] }, "reaction_10487651": { "compartment": "compartment_263163", "id": "reaction_10487651", "reactome": "R-DME-8847534", "name": "RAB43 hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487644" ], "products": [ "species_10487648" ], "modifiers": [ [ "species_10487644", "catalyst" ] ], "additional_components": [ "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29438", "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29420", "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29438" ] }, "reaction_10487252": { "compartment": "compartment_263163", "id": "reaction_10487252", "reactome": "R-DME-6814091", "name": "ARL1 recruits TGN Golgin homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487206", "species_10487248" ], "products": [ "species_10487250" ], "modifiers": [], "additional_components": [ "P25160", "FBgn0000115", "species_29438", "Q9W389", "FBgn0030088", "Q9VHP1", "FBgn0037603", "Q9VGE4", "FBgn0037979", "Q9W1R3", "FBgn0034854", "Q9VGR1", "FBgn0037881", "Q7K4K7", "FBgn0086757", "Q9W3V2", "FBgn0029912", "Q9VGE4", "FBgn0037979", "Q9W1R3", "FBgn0034854", "Q9VGR1", "FBgn0037881", "Q7K4K7", "FBgn0086757", "Q9W3V2", "FBgn0029912", "P25160", "FBgn0000115", "species_29438", "Q9W389", "FBgn0030088", "Q9VHP1", "FBgn0037603" ] }, "reaction_10487270": { "compartment": "compartment_70101", "id": "reaction_10487270", "reactome": "R-DME-6814096", "name": "ARL1:GTP binds SCOC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487266", "species_10487200" ], "products": [ "species_10487268" ], "modifiers": [], "additional_components": [ "FBgn0039505", "species_29438", "P25160", "FBgn0000115", "species_29438", "P25160", "FBgn0000115", "Q9VB51", "FBgn0039505" ] }, "reaction_10487655": { "compartment": "compartment_263163", "id": "reaction_10487655", "reactome": "R-DME-8847537", "name": "RAB43:GTP binds USP8NL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487642", "species_10487653" ], "products": [ "species_10487644" ], "modifiers": [], "additional_components": [ "O18339", "FBgn0015793", "species_29438", "FBgn0020620", "A1Z9K4", "FBgn0020620", "O18339", "FBgn0015793", "species_29438" ] }, "reaction_10487208": { "compartment": "compartment_263163", "id": "reaction_10487208", "reactome": "R-DME-6814086", "name": "ARFRP1 recruits ARL1 to the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487192", "species_10487200" ], "products": [ "species_10487206" ], "modifiers": [], "additional_components": [ "Q9W389", "FBgn0030088", "species_29438", "Q9VHP1", "FBgn0037603", "species_29438", "P25160", "FBgn0000115", "P25160", "FBgn0000115", "species_29438", "Q9W389", "FBgn0030088", "Q9VHP1", "FBgn0037603" ] }, "reaction_10487562": { "compartment": "compartment_263163", "id": "reaction_10487562", "reactome": "R-DME-6814676", "name": "SNAPs and NSF hexamer bind cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478736", "species_10478727", "species_10487552" ], "products": [ "species_10487560" ], "modifiers": [], "additional_components": [ "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487261": { "compartment": "compartment_70101", "id": "reaction_10487261", "reactome": "R-DME-6814094", "name": "ARL1:GTP binds ARFIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487257", "species_10487200" ], "products": [ "species_10487259" ], "modifiers": [], "additional_components": [ "FBgn0037884", "species_29438", "P25160", "FBgn0000115", "species_29438", "P25160", "FBgn0000115", "Q9VGQ8", "FBgn0037884" ] }, "reaction_10487565": { "compartment": "compartment_263163", "id": "reaction_10487565", "reactome": "R-DME-6814678", "name": "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10487560" ], "products": [ "species_10478736", "species_29370", "species_10478727", "species_10487508", "species_10487522", "species_10487506", "species_10487504" ], "modifiers": [ [ "species_10487560", "catalyst" ] ], "additional_components": [ "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791", "Q23983", "FBgn0250791", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "FBgn0260862", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "FBgn0031106", "FBgn0037084", "Q7JY00", "FBgn0037084", "Q9VR90", "FBgn0031106", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9W0N6", "FBgn0260862", "P46461", "FBgn0000346", "P54351", "FBgn0266464", "Q23983", "FBgn0250791" ] }, "reaction_10487214": { "compartment": "compartment_263163", "id": "reaction_10487214", "reactome": "R-DME-6814088", "name": "SYS1 binds AcM-ARFRP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487182", "species_10487212" ], "products": [ "species_10487192" ], "modifiers": [], "additional_components": [ "FBgn0037603", "Q9W389", "FBgn0030088", "species_29438", "Q9W389", "FBgn0030088", "species_29438", "Q9VHP1", "FBgn0037603" ] }, "reaction_10447993": { "compartment": "compartment_70101", "id": "reaction_10447993", "reactome": "R-DME-421835", "name": "trans-Golgi Network Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447892" ], "products": [ "species_10439074", "species_29372", "species_29420", "species_10447990", "species_10447884" ], "modifiers": [ [ "species_10447892", "catalyst" ] ], "additional_components": [ "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P27619", "FBgn0003392", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P27619", "FBgn0003392", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833" ] }, "reaction_10447894": { "compartment": "compartment_20699", "id": "reaction_10447894", "reactome": "R-DME-421831", "name": "trans-Golgi Network Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439074", "species_10447876", "species_10447882", "species_10447884" ], "products": [ "species_29372", "species_10447892", "species_10444042" ], "modifiers": [], "additional_components": [ "FBgn0038659", "P61209", "FBgn0010348", "species_29438", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P27619", "FBgn0003392", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P61209", "FBgn0010348", "species_29420" ] }, "reaction_10449633": { "compartment": "compartment_70101", "id": "reaction_10449633", "reactome": "R-DME-434362", "name": "Recruitment Of Cytoplasmic Proteins To Vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447984", "species_10449619", "species_10449624", "species_10449610", "species_10449629" ], "products": [ "species_10447984", "species_10449631" ], "modifiers": [], "additional_components": [ "Q9VYH1", "FBgn0030449", "FBgn0003165", "FBgn0261279", "FBgn0010877", "Q9VE96", "FBgn0010877", "Q8IN05", "FBgn0261279", "P25822", "FBgn0003165", "Q9VYH1", "FBgn0030449" ] }, "reaction_10475663": { "compartment": "compartment_20699", "id": "reaction_10475663", "reactome": "R-DME-5671702", "name": "AP1G2 binds HGS and CHMP2A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439057", "species_10454937", "species_10475659" ], "products": [ "species_10475661" ], "modifiers": [], "additional_components": [ "FBgn0031450", "FBgn0039402", "FBgn0030089", "Q7KVR8", "FBgn0030089", "Q9VBI3", "FBgn0039402", "Q960X8", "FBgn0031450" ] }, "reaction_10449498": { "compartment": "compartment_70101", "id": "reaction_10449498", "reactome": "R-DME-432707", "name": "trans-Golgi Network Lysosomal Vesicle Scission", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449493" ], "products": [ "species_10439074", "species_29372", "species_10449475", "species_29420", "species_10447884" ], "modifiers": [ [ "species_10449493", "catalyst" ] ], "additional_components": [ "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P27619", "FBgn0003392", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P27619", "FBgn0003392" ] }, "reaction_10449495": { "compartment": "compartment_70101", "id": "reaction_10449495", "reactome": "R-DME-432706", "name": "trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449489", "species_10439074", "species_10447882", "species_10447884" ], "products": [ "species_29372", "species_10449493", "species_10444042" ], "modifiers": [], "additional_components": [ "P61209", "FBgn0010348", "species_29438", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "FBgn0003392", "Q8T390", "FBgn0038659", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q24253", "FBgn0010380", "Q7KVR8", "FBgn0030089", "B8A403", "FBgn0039132", "O62531", "FBgn0024833", "P27619", "FBgn0003392", "P61209", "FBgn0010348", "species_29420" ] }, "reaction_10471574": { "compartment": "compartment_263163", "id": "reaction_10471574", "reactome": "R-DME-5333658", "name": "CLAT:AP1:CLVS bind PI(3,5)P2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5334668", "species_10471570" ], "products": [ "species_10471572" ], "modifiers": [], "additional_components": [ "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "B8A403", "FBgn0039132", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "P29742", "FBgn0000319", "species_1806289", "O62531", "FBgn0024833", "Q7KVR8", "FBgn0030089", "Q24253", "FBgn0010380", "B8A403", "FBgn0039132", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "P29742", "FBgn0000319" ] }, "reaction_10444054": { "compartment": "compartment_70101", "id": "reaction_10444054", "reactome": "R-DME-350769", "name": "trans-Golgi Network Coat Activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10444042" ], "products": [ "species_29420", "species_10444046" ], "modifiers": [ [ "species_10444051", "catalyst" ] ], "additional_components": [ "P61209", "FBgn0010348", "species_29420", "P61209", "FBgn0010348", "species_29438", "FBgn0264560" ] }, "reaction_10455085": { "compartment": "compartment_70101", "id": "reaction_10455085", "reactome": "R-DME-917700", "name": "MVB Vesicle Formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454980", "species_10455081" ], "products": [ "species_10455014", "species_10455079" ], "modifiers": [], "additional_components": [ "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027" ] }, "reaction_10455083": { "compartment": "compartment_70101", "id": "reaction_10455083", "reactome": "R-DME-917696", "name": "Cargo Sequestration", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455062", "species_10455079" ], "products": [ "species_10455060", "species_10455081" ], "modifiers": [], "additional_components": [ "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027", "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "Q9VD72", "FBgn0260940", "Q9VU87", "FBgn0086785", "Q7JXV9", "FBgn0022027", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10455091": { "compartment": "compartment_876", "id": "reaction_10455091", "reactome": "R-DME-917730", "name": "Cargo Recognition And Sorting", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455089", "species_10455060" ], "products": [ "species_10455062", "species_10455087" ], "modifiers": [], "additional_components": [ "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "Q9V359", "FBgn0021814", "Q9VN88", "FBgn0037299", "O77259", "FBgn0016038", "Q9VWY7", "FBgn0030894", "Q9VHX1", "FBgn0037539", "Q9VVA7", "FBgn0036666", "species_179838", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9XTL2", "FBgn0027363", "Q960X8", "FBgn0031450" ] }, "reaction_10465199": { "compartment": "compartment_984", "id": "reaction_10465199", "reactome": "R-DME-2168886", "name": "Hemopexin binds Hemes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_9707310", "species_10465195" ], "products": [ "species_10465197" ], "modifiers": [], "additional_components": [ "species_71185", "FBgn0035049", "Q9W122", "FBgn0035049", "species_71185" ] }, "reaction_10442798": { "compartment": "compartment_70101", "id": "reaction_10442798", "reactome": "R-DME-209859", "name": "Decarboxylation of 5-hydroxytryptophan forms serotonin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209911" ], "products": [ "species_113528", "species_209914" ], "modifiers": [ [ "species_10442795", "catalyst" ] ], "additional_components": [ "P05031", "FBgn0000422" ] }, "reaction_10442780": { "compartment": "compartment_70101", "id": "reaction_10442780", "reactome": "R-DME-209828", "name": "Tryptophan is hydroxylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29500", "species_29368" ], "products": [ "species_71112", "species_209911" ], "modifiers": [ [ "species_10442777", "catalyst" ] ], "additional_components": [ "Q9W0K2", "FBgn0035187", "species_111793" ] }, "reaction_10449260": { "compartment": "compartment_70101", "id": "reaction_10449260", "reactome": "R-DME-432148", "name": "Fgr may phosphorylate p38 MAPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448753", "species_113592" ], "products": [ "species_29370", "species_10439430" ], "modifiers": [ [ "species_10449257", "catalyst" ] ], "additional_components": [ "FBgn0024846", "FBgn0024846", "FBgn0262733" ] }, "reaction_10447546": { "compartment": "compartment_70101", "id": "reaction_10447546", "reactome": "R-DME-418456", "name": "cGMP is degraded by PDEs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30991" ], "products": [ "species_113578" ], "modifiers": [ [ "species_10447543", "catalyst" ] ], "additional_components": [ "Q9VJ79", "FBgn0085370", "Q9VFI9", "FBgn0038237", "B7YZV4", "FBgn0264815" ] }, "reaction_10447521": { "compartment": "compartment_70101", "id": "reaction_10447521", "reactome": "R-DME-418436", "name": "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468", "species_29368", "species_29364" ], "products": [ "species_202124", "species_29366", "species_29968" ], "modifiers": [ [ "species_10447516", "catalyst" ] ], "additional_components": [ "FBgn0011676" ] }, "reaction_10448285": { "compartment": "compartment_876", "id": "reaction_10448285", "reactome": "R-DME-426223", "name": "Cation influx mediated by TRPC3/6/7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_426219" ], "products": [ "species_426221" ], "modifiers": [ [ "species_10448280", "catalyst" ] ], "additional_components": [ "species_74113", "species_74016", "species_29926", "species_74016", "species_29926", "species_74113", "species_114519", "Q9VJJ7", "FBgn0032593", "P48994", "FBgn0005614", "P19334", "FBgn0003861" ] }, "reaction_10484607": { "compartment": "compartment_7660", "id": "reaction_10484607", "reactome": "R-DME-6799431", "name": "TP53 binds HIPK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467611", "species_10484603" ], "products": [ "species_10484605" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0035142", "Q9W0Q1", "FBgn0035142", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486113": { "compartment": "compartment_7660", "id": "reaction_10486113", "reactome": "R-DME-6805276", "name": "CDK5 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_113582", "species_10486103" ], "modifiers": [ [ "species_10486110", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P48609", "FBgn0013762", "Q9V3H5", "FBgn0027491" ] }, "reaction_10486083": { "compartment": "compartment_7660", "id": "reaction_10486083", "reactome": "R-DME-6805109", "name": "CDK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_113582", "species_10486081" ], "modifiers": [ [ "species_10427405", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P23573", "FBgn0004107" ] }, "reaction_10484601": { "compartment": "compartment_7660", "id": "reaction_10484601", "reactome": "R-DME-6799409", "name": "HIPK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467602" ], "products": [ "species_10467600", "species_113582", "species_10467592", "species_10481386" ], "modifiers": [ [ "species_10467602", "catalyst" ] ], "additional_components": [ "M9NFM7", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "M9NFM7", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379" ] }, "reaction_10486087": { "compartment": "compartment_7660", "id": "reaction_10486087", "reactome": "R-DME-6805122", "name": "AURKB binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470050", "species_10467755" ], "products": [ "species_10486085" ], "modifiers": [], "additional_components": [ "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227" ] }, "reaction_10486121": { "compartment": "compartment_7660", "id": "reaction_10486121", "reactome": "R-DME-6805399", "name": "TAF1 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_113582", "species_10486118" ], "modifiers": [ [ "species_10431420", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10467604": { "compartment": "compartment_7660", "id": "reaction_10467604", "reactome": "R-DME-3215251", "name": "TP53INP1 and HIPK2 bind TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467600", "species_10427813", "species_10467592" ], "products": [ "species_10467602" ], "modifiers": [], "additional_components": [ "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379", "Q8IMZ4", "FBgn0039044", "FBgn0035542", "M9NFM7", "FBgn0035542", "Q8IMZ4", "FBgn0039044", "Q9W0Q1", "FBgn0035142", "P54353", "FBgn0015379" ] }, "reaction_10481389": { "compartment": "compartment_7660", "id": "reaction_10481389", "reactome": "R-DME-6798374", "name": "DYRK2 phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427813" ], "products": [ "species_113582", "species_10481386" ], "modifiers": [ [ "species_10481378", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0027101" ] }, "reaction_10467757": { "compartment": "compartment_7660", "id": "reaction_10467757", "reactome": "R-DME-3222128", "name": "NOC2L binds TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10467753" ], "products": [ "species_10467755" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0032925", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486098": { "compartment": "compartment_7660", "id": "reaction_10486098", "reactome": "R-DME-6805126", "name": "AURKB phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10486085" ], "products": [ "species_10486095", "species_113582" ], "modifiers": [ [ "species_10486085", "catalyst" ] ], "additional_components": [ "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227", "Q9VIF0", "FBgn0032925", "Q8IMZ4", "FBgn0039044", "Q9VGF9", "FBgn0000147", "Q9VKN7", "FBgn0024227" ] }, "reaction_10486134": { "compartment": "compartment_7660", "id": "reaction_10486134", "reactome": "R-DME-6805470", "name": "AMPK phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_10427808", "species_113582" ], "modifiers": [ [ "species_10486131", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "O18645", "FBgn0023169", "A1Z7Q8", "FBgn0260972", "species_76577", "Q9VDD2", "FBgn0264357" ] }, "reaction_10486074": { "compartment": "compartment_7660", "id": "reaction_10486074", "reactome": "R-DME-6805059", "name": "CK2:FACT phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427813" ], "products": [ "species_113582", "species_10486053" ], "modifiers": [ [ "species_10486071", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278" ] }, "reaction_10486076": { "compartment": "compartment_7660", "id": "reaction_10486076", "reactome": "R-DME-6805061", "name": "CK2 binds FACT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434698", "species_10486069" ], "products": [ "species_10486071" ], "modifiers": [], "additional_components": [ "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "P08181", "CkIIalpha", "P08182", "CkIIbeta", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278" ] }, "reaction_10486142": { "compartment": "compartment_7660", "id": "reaction_10486142", "reactome": "R-DME-6805479", "name": "TP53RK phosphorylates TP53", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467611" ], "products": [ "species_10427808", "species_113582" ], "modifiers": [ [ "species_10486139", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "FBgn0035590" ] }, "reaction_10486000": { "compartment": "compartment_7660", "id": "reaction_10486000", "reactome": "R-DME-6804402", "name": "TP53 binds POU4F1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485996", "species_10427813" ], "products": [ "species_10485998" ], "modifiers": [], "additional_components": [ "FBgn0000028", "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "P24350", "FBgn0000028" ] }, "reaction_10486006": { "compartment": "compartment_7660", "id": "reaction_10486006", "reactome": "R-DME-6804425", "name": "TP53 binds POU4F2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427813", "species_10486002" ], "products": [ "species_10486004" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0000028", "P24350", "FBgn0000028", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10467785": { "compartment": "compartment_7660", "id": "reaction_10467785", "reactome": "R-DME-3222259", "name": "PHF20 binds TP53 dimethylated on K370 and K382", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467781", "species_10467775" ], "products": [ "species_10467783" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0038016", "Q9VGA4", "FBgn0038016", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486215": { "compartment": "compartment_7660", "id": "reaction_10486215", "reactome": "R-DME-6805785", "name": "AKT phosphorylates PHF20", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467775" ], "products": [ "species_113582", "species_10486213" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [ "FBgn0038016", "FBgn0038016" ] }, "reaction_10484676": { "compartment": "compartment_7660", "id": "reaction_10484676", "reactome": "R-DME-6799777", "name": "TP53 family members bind PPP1R13B or TP53BP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481317", "species_10484670" ], "products": [ "species_10484674" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "FBgn0034606", "Q86BG1", "FBgn0034606", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10486219": { "compartment": "compartment_7660", "id": "reaction_10486219", "reactome": "R-DME-6805792", "name": "p-S291-PHF20 translocates to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10486213" ], "products": [ "species_10486217" ], "modifiers": [], "additional_components": [ "FBgn0038016", "FBgn0038016" ] }, "reaction_10486046": { "compartment": "compartment_7660", "id": "reaction_10486046", "reactome": "R-DME-6804762", "name": "TP53 forms homotetramers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467282" ], "products": [ "species_10467611" ], "modifiers": [], "additional_components": [ "FBgn0039044", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10474397": { "compartment": "compartment_70101", "id": "reaction_10474397", "reactome": "R-DME-5632738", "name": "DDIT4 binds 14-3-3 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432018", "species_10474390" ], "products": [ "species_10474392" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "Q9VTH4", "FBgn0041094", "Q9VTI8", "FBgn0036165", "Q9VTH4", "FBgn0041094", "Q9VTI8", "FBgn0036165", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon" ] }, "reaction_10474394": { "compartment": "compartment_70101", "id": "reaction_10474394", "reactome": "R-DME-5632732", "name": "p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432018", "species_10440825" ], "products": [ "species_10474378" ], "modifiers": [ [ "species_10474392", "inhibitor" ] ], "additional_components": [ "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "FBgn0005198", "Q9VW83", "FBgn0005198", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon", "Q9VTH4", "FBgn0041094", "Q9VTI8", "FBgn0036165", "P29310", "14-3-3zeta", "P92177", "14-3-3epsilon" ] }, "reaction_10474353": { "compartment": "compartment_70101", "id": "reaction_10474353", "reactome": "R-DME-5631941", "name": "SESN1,2,3 bind AMPK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474341", "species_10445887" ], "products": [ "species_10474351" ], "modifiers": [], "additional_components": [ "FBgn0034897", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9W1K5", "FBgn0034897" ] }, "reaction_10436944": { "compartment": "compartment_70101", "id": "reaction_10436944", "reactome": "R-DME-165179", "name": "Formation of TSC1:TSC2 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436938", "species_10436925" ], "products": [ "species_10436942" ], "modifiers": [], "additional_components": [ "FBgn0026317", "FBgn0005198", "Q9VW83", "FBgn0005198", "Q9VCC9", "FBgn0026317" ] }, "reaction_10474349": { "compartment": "compartment_70101", "id": "reaction_10474349", "reactome": "R-DME-5631903", "name": "SESN1,2,3 bind overoxidized PRDX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474341", "species_10474333" ], "products": [ "species_10474347" ], "modifiers": [], "additional_components": [ "FBgn0034897", "Q9V3P0", "FBgn0040309", "Q9V3P0", "FBgn0040309", "Q9W1K5", "FBgn0034897" ] }, "reaction_10474336": { "compartment": "compartment_70101", "id": "reaction_10474336", "reactome": "R-DME-5631885", "name": "PRDX1 overoxidizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468393", "species_29408" ], "products": [ "species_29356", "species_10474333" ], "modifiers": [ [ "species_10468393", "catalyst" ] ], "additional_components": [ "Q9V3P0", "FBgn0040309", "Q9V3P0", "FBgn0040309", "Q9V3P0", "FBgn0040309" ] }, "reaction_10481119": { "compartment": "compartment_7660", "id": "reaction_10481119", "reactome": "R-DME-6797100", "name": "CCNK binds CDK13", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434613", "species_10481115" ], "products": [ "species_10481117" ], "modifiers": [], "additional_components": [ "FBgn0025674", "FBgn0037093", "Q9VP22", "FBgn0037093", "Q961D1", "FBgn0025674" ] }, "reaction_10481276": { "compartment": "compartment_7660", "id": "reaction_10481276", "reactome": "R-DME-6797616", "name": "CCNK:CDK12 binds RNA Pol II at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481111", "species_10481256" ], "products": [ "species_10481258" ], "modifiers": [], "additional_components": [ "Q961D1", "FBgn0025674", "Q9VP22", "FBgn0037093", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9VP22", "FBgn0037093" ] }, "reaction_10481274": { "compartment": "compartment_7660", "id": "reaction_10481274", "reactome": "R-DME-6797606", "name": "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10481258" ], "products": [ "species_113582", "species_10481271" ], "modifiers": [ [ "species_10481258", "catalyst" ] ], "additional_components": [ "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9VP22", "FBgn0037093", "Q961D1", "FBgn0025674", "Q9VP22", "FBgn0037093", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VW51", "FBgn0014037", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "P04052", "FBgn0003277", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "O96433", "FBgn0025455", "O17432", "FBgn0019949", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "P20232", "FBgn0010422", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VW51", "FBgn0014037", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9VP22", "FBgn0037093" ] }, "reaction_10481113": { "compartment": "compartment_7660", "id": "reaction_10481113", "reactome": "R-DME-6797090", "name": "CCNK binds CDK12", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481109", "species_10434613" ], "products": [ "species_10481111" ], "modifiers": [], "additional_components": [ "FBgn0037093", "FBgn0025674", "Q961D1", "FBgn0025674", "Q9VP22", "FBgn0037093" ] }, "reaction_10485756": { "compartment": "compartment_70101", "id": "reaction_10485756", "reactome": "R-DME-6800793", "name": "PIDD1 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485748" ], "products": [ "species_10485754" ], "modifiers": [], "additional_components": [ "Q960C5", "FBgn0032633", "Q9W2D7", "FBgn0034655", "Q9W2D7", "FBgn0034655", "Q960C5", "FBgn0032633" ] }, "reaction_10485783": { "compartment": "compartment_70101", "id": "reaction_10485783", "reactome": "R-DME-6801109", "name": "CHM binds RGGT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485772", "species_10485779" ], "products": [ "species_10485781" ], "modifiers": [], "additional_components": [ "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "FBgn0026378", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970" ] }, "reaction_10485774": { "compartment": "compartment_876", "id": "reaction_10485774", "reactome": "R-DME-6801101", "name": "RABGGTA binds RABGGTB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485770", "species_10485765" ], "products": [ "species_10485772" ], "modifiers": [], "additional_components": [ "FBgn0028970", "FBgn0037293", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970" ] }, "reaction_10485804": { "compartment": "compartment_17927", "id": "reaction_10485804", "reactome": "R-DME-6801242", "name": "TRIAP1 binds PRELID1, PRELID3A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485788", "species_10485800" ], "products": [ "species_10485802" ], "modifiers": [], "additional_components": [ "FBgn0050109", "Q9V579", "FBgn0033413", "Q9V579", "FBgn0033413", "Q6NLJ9", "FBgn0050109" ] }, "reaction_10485807": { "compartment": "compartment_17906", "id": "reaction_10485807", "reactome": "R-DME-6801250", "name": "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1500590" ], "products": [ "species_1524101" ], "modifiers": [ [ "species_10485802", "catalyst" ] ], "additional_components": [ "Q9V579", "FBgn0033413", "Q6NLJ9", "FBgn0050109" ] }, "reaction_10430972": { "compartment": "compartment_70101", "id": "reaction_10430972", "reactome": "R-DME-73608", "name": "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500829" ], "products": [ "species_500430", "species_31633" ], "modifiers": [ [ "species_10430969", "catalyst" ] ], "additional_components": [ "CHEBI:15698", "CHEBI:17562", "CHEBI:16450", "CHEBI:16704", "species_1562550", "Q9VLR3", "FBgn0032001" ] }, "reaction_10433723": { "compartment": "compartment_5460", "id": "reaction_10433723", "reactome": "R-DME-109759", "name": "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_500822" ], "products": [ "species_113581", "species_500823" ], "modifiers": [ [ "species_10433720", "catalyst" ] ], "additional_components": [ "CHEBI:17748", "CHEBI:16450", "CHEBI:15698", "species_109366", "species_109382", "CHEBI:15918", "FBgn0022338" ] }, "reaction_10431579": { "compartment": "compartment_70101", "id": "reaction_10431579", "reactome": "R-DME-74372", "name": "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_83962", "species_500244" ], "products": [ "species_29372", "species_500430" ], "modifiers": [ [ "species_10431576", "catalyst" ] ], "additional_components": [ "CHEBI:28542", "species_112016", "CHEBI:16450", "CHEBI:16704", "Q9VBA0", "FBgn0039464", "Q8T8S2", "FBgn0034800", "Q0E8U4", "FBgn0031489" ] }, "reaction_10433803": { "compartment": "compartment_70101", "id": "reaction_10433803", "reactome": "R-DME-109903", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10433800", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_1524067", "species_418075", "Q9VC99", "FBgn0263398" ] }, "reaction_10430952": { "compartment": "compartment_70101", "id": "reaction_10430952", "reactome": "R-DME-73599", "name": "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10430949", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_1524067", "species_418075", "Q9VC99", "FBgn0263398" ] }, "reaction_10479975": { "compartment": "compartment_70101", "id": "reaction_10479975", "reactome": "R-DME-6788295", "name": "HDHD1:Mg2+ dephosphorylates PURIDP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6788291" ], "products": [ "species_29372", "species_6788290" ], "modifiers": [ [ "species_10479972", "catalyst" ] ], "additional_components": [ "species_29926", "Q94529", "FBgn0019982" ] }, "reaction_10495070": { "compartment": "compartment_70101", "id": "reaction_10495070", "reactome": "R-DME-8954327", "name": "UCKL1 phosphorylates urindine, cytidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_500759" ], "products": [ "species_500761", "species_29370" ], "modifiers": [ [ "species_10495067", "catalyst" ] ], "additional_components": [ "CHEBI:16704", "CHEBI:17562", "species_1524067", "species_418075", "FBgn0022029" ] }, "reaction_10427902": { "compartment": "compartment_70101", "id": "reaction_10427902", "reactome": "R-DME-70361", "name": "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30170", "species_29410" ], "products": [ "species_29452", "species_29548" ], "modifiers": [ [ "species_10427899", "catalyst" ] ], "additional_components": [ "FBgn0263200" ] }, "reaction_10427912": { "compartment": "compartment_70101", "id": "reaction_10427912", "reactome": "R-DME-70369", "name": "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29452" ], "products": [ "species_29410" ], "modifiers": [ [ "species_10427909", "catalyst" ] ], "additional_components": [ "species_427523", "Q9W0P5", "FBgn0035147" ] }, "reaction_10427975": { "compartment": "compartment_70101", "id": "reaction_10427975", "reactome": "R-DME-70427", "name": "PGM:Mg2+ isomerise G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10427861", "catalyst" ] ], "additional_components": [ "species_29926", "A1Z7P1", "FBgn0033377", "A1Z9V3", "FBgn0033969" ] }, "reaction_10488852": { "compartment": "compartment_161320", "id": "reaction_10488852", "reactome": "R-DME-8853686", "name": "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1605715", "species_8853396" ], "products": [ "species_6799577", "species_6799594" ], "modifiers": [ [ "species_10488849", "catalyst" ] ], "additional_components": [ "Q8IPB7", "FBgn0027611", "species_1562550" ] }, "reaction_10484649": { "compartment": "compartment_161320", "id": "reaction_10484649", "reactome": "R-DME-6799581", "name": "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799577", "species_1605715" ], "products": [ "species_6799594", "species_8853719" ], "modifiers": [ [ "species_10484646", "catalyst" ] ], "additional_components": [ "Q9VKV2", "FBgn0032253", "Q9VLI1", "FBgn0032067", "Q8IPB7", "FBgn0027611", "Q9VLI0", "FBgn0032068", "Q9VLH9", "FBgn0032069", "Q9VLI2", "FBgn0032066", "species_1562550" ] }, "reaction_10488857": { "compartment": "compartment_161320", "id": "reaction_10488857", "reactome": "R-DME-8853710", "name": "MANBA hydrolyses GlcNAc:Man", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8853719" ], "products": [ "species_1678743", "species_6799594" ], "modifiers": [ [ "species_10488854", "catalyst" ] ], "additional_components": [ "FBgn0037215" ] }, "reaction_10497920": { "compartment": "compartment_70101", "id": "reaction_10497920", "reactome": "R-DME-9638125", "name": "PGM1:Mg2+ isomerises G1P to G6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29548" ], "products": [ "species_30537" ], "modifiers": [ [ "species_10497917", "catalyst" ] ], "additional_components": [ "species_29926", "Q9VUY9", "FBgn0003076" ] }, "reaction_10428999": { "compartment": "compartment_70101", "id": "reaction_10428999", "reactome": "R-DME-71541", "name": "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10428910" ], "products": [ "species_10428915", "species_29370" ], "modifiers": [ [ "species_10428996", "catalyst" ], [ "species_74016", "catalyst" ] ], "additional_components": [ "Q9XTL9", "FBgn0004507", "Q9XTL9", "FBgn0004507", "Q9VLS1", "FBgn0031995", "Q9W391", "FBgn0030087", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592" ] }, "reaction_10451638": { "compartment": "compartment_70101", "id": "reaction_10451638", "reactome": "R-DME-453342", "name": "PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428910", "species_76577" ], "products": [ "species_10451634" ], "modifiers": [ [ "species_30537", "inhibitor" ], [ "species_113592", "inhibitor" ] ], "additional_components": [ "Q9XTL9", "FBgn0004507", "species_76577", "Q9XTL9", "FBgn0004507" ] }, "reaction_10428063": { "compartment": "compartment_70101", "id": "reaction_10428063", "reactome": "R-DME-70479", "name": "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30014", "species_29356" ], "products": [ "species_29372", "species_29512" ], "modifiers": [ [ "species_10428060", "catalyst" ], [ "species_76577", "inhibitor" ] ], "additional_components": [ "species_29926", "A0A0U1RVK6", "FBgn0032820" ] }, "reaction_10468121": { "compartment": "compartment_17957", "id": "reaction_10468121", "reactome": "R-DME-3262512", "name": "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10468118", "catalyst" ] ], "additional_components": [ "FBgn0031463" ] }, "reaction_10444376": { "compartment": "compartment_5460", "id": "reaction_10444376", "reactome": "R-DME-372819", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113573", "species_113587" ], "products": [ "species_372364", "species_113525", "species_29376" ], "modifiers": [ [ "species_10444373", "catalyst" ] ], "additional_components": [ "FBgn0003067" ] }, "reaction_10444312": { "compartment": "compartment_70101", "id": "reaction_10444312", "reactome": "R-DME-372449", "name": "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190", "species_372364" ], "products": [ "species_29654", "species_29492" ], "modifiers": [ [ "species_10432422", "catalyst" ] ], "additional_components": [ "FBgn0037912" ] }, "reaction_10440823": { "compartment": "compartment_70101", "id": "reaction_10440823", "reactome": "R-DME-198508", "name": "malate + NAD+ <=> oxaloacetate + NADH + H+", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_198498", "species_29360" ], "products": [ "species_70106", "species_76213", "species_73473" ], "modifiers": [ [ "species_10440820", "catalyst" ] ], "additional_components": [ "Q9VKX2", "FBgn0262782" ] }, "reaction_10427830": { "compartment": "compartment_70101", "id": "reaction_10427830", "reactome": "R-DME-70241", "name": "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_76213" ], "products": [ "species_29420", "species_113528", "species_29492" ], "modifiers": [ [ "species_10427827", "catalyst" ] ], "additional_components": [ "P20007", "FBgn0003067", "Q7JXB5", "FBgn0034356" ] }, "reaction_10428116": { "compartment": "compartment_5460", "id": "reaction_10428116", "reactome": "R-DME-70501", "name": "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113593", "species_113557", "species_29376" ], "products": [ "species_113548", "species_113581", "species_113587" ], "modifiers": [ [ "species_10428113", "catalyst" ], [ "species_113559", "catalyst" ] ], "additional_components": [ "Q0E9E2", "FBgn0027580", "species_266099", "species_199238" ] }, "reaction_10468116": { "compartment": "compartment_70101", "id": "reaction_10468116", "reactome": "R-DME-3257122", "name": "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113551", "species_30537" ], "products": [ "species_29372", "species_113782" ], "modifiers": [ [ "species_10468111", "catalyst" ] ], "additional_components": [ "FBgn0034611" ] }, "reaction_10440813": { "compartment": "compartment_70101", "id": "reaction_10440813", "reactome": "R-DME-198440", "name": "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29406", "species_113544" ], "products": [ "species_113594", "species_198498" ], "modifiers": [ [ "species_10440810", "catalyst" ] ], "additional_components": [ "Q9VAJ9", "FBgn0039674" ] }, "reaction_10445386": { "compartment": "compartment_70101", "id": "reaction_10445386", "reactome": "R-DME-376851", "name": "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_198498" ], "products": [ "species_29406", "species_113544" ], "modifiers": [ [ "species_10440810", "catalyst" ] ], "additional_components": [ "Q9VAJ9", "FBgn0039674" ] }, "reaction_10468169": { "compartment": "compartment_17957", "id": "reaction_10468169", "reactome": "R-DME-3266566", "name": "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10468166", "catalyst" ] ], "additional_components": [ "FBgn0031463" ] }, "reaction_10428264": { "compartment": "compartment_5460", "id": "reaction_10428264", "reactome": "R-DME-70613", "name": "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113587", "species_113552" ], "products": [ "species_113594", "species_113553" ], "modifiers": [ [ "species_10428224", "catalyst" ] ], "additional_components": [ "Q8IPY3", "FBgn0001125" ] }, "reaction_10429153": { "compartment": "compartment_17957", "id": "reaction_10429153", "reactome": "R-DME-71825", "name": "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_113782" ], "products": [ "species_113551", "species_113780" ], "modifiers": [ [ "species_10429150", "catalyst" ] ], "additional_components": [ "FBgn0031463" ] }, "reaction_10474612": { "compartment": "compartment_70101", "id": "reaction_10474612", "reactome": "R-DME-5652172", "name": "AKR1B1 reduces Glc to D-sorbitol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_70113" ], "products": [ "species_29366", "species_5652213" ], "modifiers": [ [ "species_10440630", "catalyst" ] ], "additional_components": [ "FBgn0086254" ] }, "reaction_10474624": { "compartment": "compartment_70101", "id": "reaction_10474624", "reactome": "R-DME-5652195", "name": "SORD oxidizes D-sorbitol to Fru", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5652213", "species_29360" ], "products": [ "species_29532", "species_70106", "species_73473" ], "modifiers": [ [ "species_10474621", "catalyst" ] ], "additional_components": [ "species_1562550", "O96299", "FBgn0022359" ] }, "reaction_10427884": { "compartment": "compartment_70101", "id": "reaction_10427884", "reactome": "R-DME-70333", "name": "KHK dimer phosphorylates Fru to Fru 1-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29532", "species_113592" ], "products": [ "species_29370", "species_31221" ], "modifiers": [ [ "species_10427881", "catalyst" ], [ "species_29804", "catalyst" ], [ "species_29370", "inhibitor" ] ], "additional_components": [ "Q9VW84", "FBgn0036942" ] }, "reaction_10484615": { "compartment": "compartment_70101", "id": "reaction_10484615", "reactome": "R-DME-6799495", "name": "GLYCTK phosphorylates DGA to 3PDGA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6799497", "species_113592" ], "products": [ "species_70106", "species_29370", "species_6799493" ], "modifiers": [ [ "species_10484612", "catalyst" ] ], "additional_components": [ "FBgn0031428" ] }, "reaction_10427894": { "compartment": "compartment_70101", "id": "reaction_10427894", "reactome": "R-DME-70342", "name": "ALDOB tetramer cleaves Fru-1-P to GA and DHAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31221" ], "products": [ "species_30393", "species_75970" ], "modifiers": [ [ "species_10427891", "catalyst" ] ], "additional_components": [ "P07764", "FBgn0000064" ] }, "reaction_10440638": { "compartment": "compartment_70101", "id": "reaction_10440638", "reactome": "R-DME-196372", "name": "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193124", "species_29360" ], "products": [ "species_196366", "species_70106", "species_73473" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10440398": { "compartment": "compartment_70101", "id": "reaction_10440398", "reactome": "R-DME-193961", "name": "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_196366" ], "products": [ "species_193092" ], "modifiers": [ [ "species_10440205", "catalyst" ] ], "additional_components": [ "Q9VVE3", "FBgn0036698" ] }, "reaction_10459245": { "compartment": "compartment_984", "id": "reaction_10459245", "reactome": "R-DME-1449687", "name": "Corticosteroids bind to CBG in blood", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1449707", "species_10459241" ], "products": [ "species_10459243" ], "modifiers": [], "additional_components": [ "CHEBI:27584", "species_193055", "species_193977", "CHEBI:16973", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "CHEBI:27584", "species_193055", "species_193977", "CHEBI:16973" ] }, "reaction_10440406": { "compartment": "compartment_17957", "id": "reaction_10440406", "reactome": "R-DME-194023", "name": "HSD11B2,HSD11B1 dimer oxidise CORT to COR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193977", "species_29366" ], "products": [ "species_70106", "species_29364", "species_194035" ], "modifiers": [ [ "species_10440403", "catalyst" ] ], "additional_components": [ "FBgn0000056" ] }, "reaction_10489504": { "compartment": "compartment_70101", "id": "reaction_10489504", "reactome": "R-DME-8862137", "name": "HSD17B2 oxidises estradiol (E2) to estrone (E1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10489501", "catalyst" ] ], "additional_components": [ "FBgn0000056" ] }, "reaction_10479237": { "compartment": "compartment_5460", "id": "reaction_10479237", "reactome": "R-DME-5696822", "name": "AKR1B15 reduces EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113563", "species_5696835" ], "products": [ "species_113529", "species_5696848", "species_113600" ], "modifiers": [ [ "species_10479234", "catalyst" ] ], "additional_components": [ "M9PF61", "FBgn0086254", "Q9VTL0", "FBgn0036183" ] }, "reaction_10478098": { "compartment": "compartment_70101", "id": "reaction_10478098", "reactome": "R-DME-5693390", "name": "HSD17B11 dehydrogenates EST17b to E1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193132", "species_29366" ], "products": [ "species_70106", "species_193066", "species_29364" ], "modifiers": [ [ "species_10478095", "catalyst" ] ], "additional_components": [ "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043" ] }, "reaction_10440273": { "compartment": "compartment_70101", "id": "reaction_10440273", "reactome": "R-DME-193143", "name": "CYP19A1 hydroxylates TEST to EST17b", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_193057" ], "products": [ "species_193132", "species_29356", "species_29366", "species_29460" ], "modifiers": [ [ "species_10440256", "catalyst" ] ], "additional_components": [ "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395" ] }, "reaction_10496005": { "compartment": "compartment_7660", "id": "reaction_10496005", "reactome": "R-DME-9009282", "name": "CDK1 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491664" ], "products": [ "species_113582", "species_10495911" ], "modifiers": [ [ "species_10437694", "catalyst" ] ], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q24040", "FBgn0013753", "P23572", "FBgn0004106", "P20439", "FBgn0000405" ] }, "reaction_10492400": { "compartment": "compartment_7660", "id": "reaction_10492400", "reactome": "R-DME-8938356", "name": "RMB14 binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492396", "species_10491656" ], "products": [ "species_10492398" ], "modifiers": [], "additional_components": [ "FBgn0011640", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q94901", "FBgn0011640" ] }, "reaction_10491660": { "compartment": "compartment_7660", "id": "reaction_10491660", "reactome": "R-DME-8877902", "name": "Activated AR binds RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491656", "species_10473354" ], "products": [ "species_10491658" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576" ] }, "reaction_10491668": { "compartment": "compartment_7660", "id": "reaction_10491668", "reactome": "R-DME-8877941", "name": "RUNX2 binds SMAD1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491662", "species_10491664" ], "products": [ "species_10491666" ], "modifiers": [], "additional_components": [ "P42003", "FBgn0011648", "O62609", "FBgn0011655", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "P42003", "FBgn0011648", "O62609", "FBgn0011655" ] }, "reaction_10495959": { "compartment": "compartment_7660", "id": "reaction_10495959", "reactome": "R-DME-9008822", "name": "PPM1D dephosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10495951" ], "products": [ "species_113541", "species_10491664" ], "modifiers": [ [ "species_10495956", "catalyst" ] ], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "FBgn0022768" ] }, "reaction_10495914": { "compartment": "compartment_7660", "id": "reaction_10495914", "reactome": "R-DME-9008412", "name": "CDK4 phosphorylates RUNX2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491664" ], "products": [ "species_113582", "species_10495911" ], "modifiers": [ [ "species_10493280", "catalyst" ] ], "additional_components": [ "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q24040", "FBgn0013753", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10495757": { "compartment": "compartment_7660", "id": "reaction_10495757", "reactome": "R-DME-8985343", "name": "RUNX2 binds SOX9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10474272", "species_10491656" ], "products": [ "species_10495755" ], "modifiers": [], "additional_components": [ "FBgn0024288", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q9VA17", "FBgn0024288" ] }, "reaction_10449051": { "compartment": "compartment_70101", "id": "reaction_10449051", "reactome": "R-DME-430021", "name": "PAN2-PAN3 complex partially deadenylates mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10449036" ], "products": [ "species_10449024", "species_76577" ], "modifiers": [ [ "species_10449048", "catalyst" ] ], "additional_components": [ "P21187", "FBgn0265297", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P21187", "FBgn0265297", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q95RR8", "FBgn0035397", "A1Z7K9", "FBgn0033352" ] }, "reaction_10493178": { "compartment": "compartment_70101", "id": "reaction_10493178", "reactome": "R-DME-8941312", "name": "ZCCHC6, ZCCHC11 are mRNA uridyltransferases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10449024", "species_6782337" ], "products": [ "species_10493168" ], "modifiers": [ [ "species_10493173", "catalyst" ] ], "additional_components": [ "P21187", "FBgn0265297", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "P21187", "FBgn0265297", "species_6782337", "Q9VHS8", "FBgn0037573", "Q02748", "FBgn0001942", "Q7K581", "FBgn0034181", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "FBgn0035889" ] }, "reaction_10488832": { "compartment": "compartment_70101", "id": "reaction_10488832", "reactome": "R-DME-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1221562" ], "products": [ "species_1221562", "species_10430300" ], "modifiers": [ [ "species_10488829", "catalyst" ] ], "additional_components": [ "P35122", "FBgn0010288", "Q9VYQ8", "FBgn0030366", "P55824", "FBgn0005632" ] }, "reaction_10488784": { "compartment": "compartment_7660", "id": "reaction_10488784", "reactome": "R-DME-8852136", "name": "UBA1 conjugates ubiquitin to UBA1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488611" ], "products": [ "species_164121", "species_10488710" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11" ] }, "reaction_10488771": { "compartment": "compartment_7660", "id": "reaction_10488771", "reactome": "R-DME-8852130", "name": "UBA1 conjugates ubiquitin to nuclear E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488732", "species_10488712" ], "products": [ "species_10488611", "species_10488769" ], "modifiers": [], "additional_components": [ "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q9I7T6", "FBgn0035455", "Q9VQ00", "FBgn0031331", "Q9VYN3", "FBgn0030386", "Q7K738", "FBgn0026316", "Q9VUR4", "FBgn0036516", "Q9Y165", "FBgn0027609", "P25867", "eff", "A1Z8B5", "FBgn0033544", "P25153", "FBgn0004436", "Q9VX25", "FBgn0030863", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P25153", "FBgn0004436", "Q9VTY6", "FBgn0264848", "Q9I7T6", "FBgn0035455", "Q9VQ00", "FBgn0031331", "Q9VYN3", "FBgn0030386", "P52485", "FBgn0015320", "Q7K738", "FBgn0026316", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q9VX25", "FBgn0030863", "A1Z8B5", "FBgn0033544", "Q9VUR4", "FBgn0036516" ] }, "reaction_10488836": { "compartment": "compartment_70101", "id": "reaction_10488836", "reactome": "R-DME-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488834" ], "products": [ "species_1221561", "species_10430729" ], "modifiers": [ [ "species_10488829", "catalyst" ] ], "additional_components": [ "P35122", "FBgn0010288", "Q9VYQ8", "FBgn0030366", "P55824", "FBgn0005632" ] }, "reaction_10488708": { "compartment": "compartment_70101", "id": "reaction_10488708", "reactome": "R-DME-8852129", "name": "UBA1 conjugates ubiquitin to cytosolic E2 enzymes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488649", "species_10488615" ], "products": [ "species_10488651", "species_10488706" ], "modifiers": [], "additional_components": [ "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "Q9VYN3", "FBgn0030386", "Q9VQ00", "FBgn0031331", "Q9I7T6", "FBgn0035455", "P52485", "FBgn0015320", "Q7JW03", "FBgn0029996", "Q7K738", "FBgn0026316", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q29R09", "FBgn0023528", "Q9VX25", "FBgn0030863", "Q9VXE8", "FBgn0267384", "P52486", "FBgn0015321", "Q8SYG3", "FBgn0058045", "Q9VUR4", "FBgn0036516", "Q9VTY6", "FBgn0264848", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "Q7JW03", "FBgn0029996", "Q9VTY6", "FBgn0264848", "P52486", "FBgn0015321", "Q7K738", "FBgn0026316", "Q9VQ00", "FBgn0031331", "Q9VYN3", "FBgn0030386", "P52485", "FBgn0015320", "Q9I7T6", "FBgn0035455", "P25867", "eff", "Q9Y165", "FBgn0027609", "Q29R09", "FBgn0023528", "Q8SYG3", "FBgn0058045", "Q9VXE8", "FBgn0267384", "Q9VUR4", "FBgn0036516", "Q9VX25", "FBgn0030863", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10488613": { "compartment": "compartment_7660", "id": "reaction_10488613", "reactome": "R-DME-8852128", "name": "UBA1 adenylates ubiquitin in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427430", "species_10488565" ], "products": [ "species_113541", "species_10488611" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0023143", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488773": { "compartment": "compartment_7660", "id": "reaction_10488773", "reactome": "R-DME-8852131", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10427430", "species_10488710" ], "products": [ "species_10488712", "species_113541" ], "modifiers": [], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488776": { "compartment": "compartment_70101", "id": "reaction_10488776", "reactome": "R-DME-8852132", "name": "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488617", "species_113592", "species_10426987" ], "products": [ "species_111294", "species_10488649" ], "modifiers": [ [ "species_10488617", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8T0L3", "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488841": { "compartment": "compartment_70101", "id": "reaction_10488841", "reactome": "R-DME-8853515", "name": "OTULIN,USP5 cleaves UBC yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488838" ], "products": [ "species_10426977", "species_10426979", "species_10426981", "species_10426983", "species_10426985", "species_10426969", "species_10426971", "species_10426973", "species_10426975" ], "modifiers": [ [ "species_10477601", "catalyst" ] ], "additional_components": [ "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0086558", "FBgn0035402" ] }, "reaction_10488779": { "compartment": "compartment_70101", "id": "reaction_10488779", "reactome": "R-DME-8852133", "name": "UBA1 conjugates ubiquitin to UBA1 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488651" ], "products": [ "species_10488617", "species_76577" ], "modifiers": [ [ "species_10488651", "catalyst" ] ], "additional_components": [ "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8T0L3", "FBgn0023143", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143" ] }, "reaction_10488845": { "compartment": "compartment_70101", "id": "reaction_10488845", "reactome": "R-DME-8853529", "name": "OTULIN,USP5 cleaves UBB yielding ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488843" ], "products": [ "species_1221567", "species_1221557", "species_1221559" ], "modifiers": [ [ "species_10477601", "catalyst" ] ], "additional_components": [ "FBgn0035402" ] }, "reaction_10488782": { "compartment": "compartment_70101", "id": "reaction_10488782", "reactome": "R-DME-8852134", "name": "UBA1 adenylates ubiquitin in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457011", "species_113592", "species_10426987" ], "products": [ "species_111294", "species_10488651" ], "modifiers": [ [ "species_10457011", "catalyst" ] ], "additional_components": [ "FBgn0023143", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P15357", "UBI-P63E 11", "P0CG69", "UBI-P63E 1", "Q9W418", "FBgn0086558", "P18101", "UBI-P63E 12", "Q8T0L3", "FBgn0023143", "FBgn0023143" ] }, "reaction_10495281": { "compartment": "compartment_7660", "id": "reaction_10495281", "reactome": "R-DME-8956659", "name": "ABL1 phosphorylates YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10458548" ], "products": [ "species_113582", "species_10495278" ], "modifiers": [ [ "species_10476652", "catalyst" ] ], "additional_components": [] }, "reaction_10495297": { "compartment": "compartment_70101", "id": "reaction_10495297", "reactome": "R-DME-8956684", "name": "ITCH polyubiquitinates TP73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495289", "species_10426987" ], "products": [ "species_10495294" ], "modifiers": [ [ "species_10456470", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q8IMZ4", "FBgn0039044", "FBgn0003557" ] }, "reaction_10495299": { "compartment": "compartment_13231", "id": "reaction_10495299", "reactome": "R-DME-8957241", "name": "TP73 tetramer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495289" ], "products": [ "species_10481315" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044" ] }, "reaction_10495269": { "compartment": "compartment_7660", "id": "reaction_10495269", "reactome": "R-DME-8956568", "name": "RUNX1 binds the core TAL1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489794", "species_10495265" ], "products": [ "species_10495267" ], "modifiers": [ [ "species_10431137", "catalyst" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "P11420", "FBgn0267821", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "M9PI02", "FBgn0265598", "Q9W4X2", "FBgn0011276", "Q7KVG9", "FBgn0013764", "P11420", "FBgn0267821", "P91623", "FBgn0001138", "Q9VKZ0", "FBgn0032223", "P52172", "FBgn0003507", "M9PI02", "FBgn0265598", "Q9W4X2", "FBgn0011276", "Q7KVG9", "FBgn0013764", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237" ] }, "reaction_10495285": { "compartment": "compartment_7660", "id": "reaction_10495285", "reactome": "R-DME-8956676", "name": "YAP1 binds TP73", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495278", "species_10481315" ], "products": [ "species_10495283" ], "modifiers": [], "additional_components": [ "Q8IMZ4", "FBgn0039044", "Q8IMZ4", "FBgn0039044", "Q45VV3", "yki" ] }, "reaction_10495301": { "compartment": "compartment_70101", "id": "reaction_10495301", "reactome": "R-DME-8957265", "name": "26S proteasome degrades TP73 polyubiquitinated by ITCH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495294" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "Q8IMZ4", "FBgn0039044", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10489814": { "compartment": "compartment_7660", "id": "reaction_10489814", "reactome": "R-DME-8865482", "name": "KMT2A (MLL) binds RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489794", "species_10489810" ], "products": [ "species_10489812" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0003862", "P20659", "FBgn0003862", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10495274": { "compartment": "compartment_7660", "id": "reaction_10495274", "reactome": "R-DME-8956639", "name": "RUNX1 binds YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458548", "species_10489794" ], "products": [ "species_10495272" ], "modifiers": [ [ "species_10476652", "inhibitor" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q45VV3", "yki" ] }, "reaction_10438764": { "compartment": "compartment_7660", "id": "reaction_10438764", "reactome": "R-DME-176973", "name": "Association of MCM8 with ORC:origin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10426917", "species_10426938" ], "products": [ "species_10426942" ], "modifiers": [], "additional_components": [ "Q24168", "FBgn0015270", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "FBgn0003227", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181" ] }, "reaction_10427248": { "compartment": "compartment_7660", "id": "reaction_10427248", "reactome": "R-DME-68849", "name": "Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427210", "species_10427244" ], "products": [ "species_10427246" ], "modifiers": [], "additional_components": [ "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q9VGW6", "FBgn0017577", "P49735", "FBgn0014861", "Q26454", "FBgn0015929", "Q9XYU0", "FBgn0020633", "Q9XYU1", "FBgn0284442", "Q9V461", "FBgn0025815", "Q7JVY2", "FBgn0000996", "Q24168", "FBgn0015270", "Q9VF30", "FBgn0003227", "O16810", "FBgn0286788", "Q7K2L1", "FBgn0005654", "Q24169", "FBgn0015271", "Q9Y1B2", "FBgn0023180", "Q9W102", "FBgn0023181", "Q9VSM9", "FBgn0035918" ] }, "reaction_10482653": { "compartment": "compartment_6799713", "id": "reaction_10482653", "reactome": "R-DME-6798747", "name": "Exocytosis of tertiary granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10482575" ], "products": [ "species_10482651" ], "modifiers": [], "additional_components": [ "O96692", "FBgn0283666", "Q9VMJ6", "FBgn0031760", "Q6NP91", "FBgn0033259", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "Q8IQC6", "FBgn0052039", "Q9VH76", "FBgn0266720", "P36975", "FBgn0011288", "Q86BK8", "FBgn0015791", "Q9VHG4", "FBgn0037671", "P45437", "FBgn0008635", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "P49283", "FBgn0011672", "P08646", "RAS85D", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "Q7KK97", "FBgn0028563", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q9VLT5", "FBgn0011230", "Q9VJW9", "FBgn0259984", "Q7YTY6", "FBgn0028988", "Q6QU65", "FBgn0265140", "X2JE21", "FBgn0259110", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9VS89", "FBgn0035798", "Q9VZA4", "FBgn0260657", "Q9NBC8", "FBgn0039595", "P12080", "FBgn0001250", "P23380", "FBgn0262736", "P09478", "FBgn0000036", "Q9VGD4", "FBgn0037989", "Q9W4F7", "FBgn0029737", "B7YZT5", "FBgn0286511", "M9PHI0", "FBgn0263220", "Q9VWE0", "dome", "Q9VWE0", "dome", "Q9W4F7", "FBgn0029737", "B7YZT5", "FBgn0286511", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9VMJ6", "FBgn0031760", "Q9VGD4", "FBgn0037989", "Q6NP91", "FBgn0033259", "P49283", "FBgn0011672", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "O96692", "FBgn0283666", "Q24117", "FBgn0011760", "O96860", "FBgn0026141", "Q86BK8", "FBgn0015791", "Q9VJD2", "FBgn0032642", "Q9V8I2", "FBgn0034350", "Q9VLT5", "FBgn0011230", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9NBC8", "FBgn0039595", "Q9VZA4", "FBgn0260657", "Q7KK97", "FBgn0028563", "P23380", "FBgn0262736", "P09478", "FBgn0000036", "Q8IQC6", "FBgn0052039", "M9PHI0", "FBgn0263220", "Q9VJW9", "FBgn0259984", "Q7YTY6", "FBgn0028988", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "P08646", "RAS85D", "P45437", "FBgn0008635", "Q9VHG4", "FBgn0037671", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140", "P12080", "FBgn0001250" ] }, "reaction_10483433": { "compartment": "compartment_1462052", "id": "reaction_10483433", "reactome": "R-DME-6798748", "name": "Exocytosis of secretory granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10483133" ], "products": [ "species_10483431" ], "modifiers": [], "additional_components": [ "Q9V3V6", "Rpt5", "Q9VDL0", "FBgn0038808", "P08736", "FBgn0284245", "P05303", "FBgn0000557", "Q9VHP0", "FBgn0263231", "Q7KN62", "FBgn0286784", "P13060", "FBgn0000559", "Q7JY94", "FBgn0034366", "B7Z0E0", "FBgn0001248", "Q9NFT9", "FBgn0042711", "Q9NFT7", "FBgn0042710", "Q7JYW9", "FBgn0001187", "Q9W330", "FBgn0001186", "Q9VCZ5", "FBgn0038978", "Q24537", "Dsp1", "Q05783", "FBgn0004362", "E1JIT5", "FBgn0038979", "M9PE19", "FBgn0035348", "Q9W1K6", "FBgn0034898", "Q9VUJ1", "Prosbeta2", "O61443", "FBgn0024846", "P40301", "Prosalpha2", "Q95083", "Prosalpha5", "Q9VY39", "FBgn0030562", "Q8T3W8", "FBgn0037879", "Q9VT82", "FBgn0036070", "Q9VY19", "FBgn0020508", "Q9W2H4", "FBgn0034623", "Q8IRL3", "FBgn0052679", "Q9VI17", "FBgn0260766", "Q9VY18", "FBgn0015010", "Q9W2H3", "FBgn0034624", "Q8IND6", "FBgn0051296", 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10483596" ], "products": [ "species_10483636" ], "modifiers": [], "additional_components": [ "O46037", "FBgn0004397", "Q94527", "Rel", "Q9W4K2", "FBgn0029708", "X2JAR4", "FBgn0261848", "Q7JQR3", "FBgn0033814", "Q8MM24", "FBgn0020416", "Q8MLZ7", "FBgn0020414", "Q23997", "FBgn0013763", "Q9W303", "FBgn0026415", "Q9VZV2", "FBgn0035398", "Q9V3D4", "FBgn0020415", "Q8T0R7", "FBgn0064237", "Q9VGN8", "FBgn0037900", "O76901", "FBgn0025382", "Q7KUC2", "FBgn0085484", "P29349", "FBgn0000382", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VE79", "FBgn0038611", "Q7K485", "FBgn0029093", "Q9VWZ7", "FBgn0030887", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q9VHE4", "FBgn0037687", "Q9VH14", "FBgn0025879", "Q7KRY7", "FBgn0263289", "Q9W122", "FBgn0035049", "Q9VJQ0", "FBgn0028888", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "A1Z9N6", "FBgn0261269", "Q9W0M1", "FBgn0035168", "P18824", "arm", "Q9VZI1", "FBgn0035499", "Q9VB21", "FBgn0039527", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "P13395", "FBgn0250789", "Q9VG73", "FBgn0038046", "O76895", "FBgn0023535", "O18388", "FBgn0262743", "Q9V9J3", "phospho-Src42A", "Q8IQM9", "FBgn0263607", "Q95TL8", "FBgn0030734", "Q86PD7", "FBgn0036999", "Q9VF87", "FBgn0038320", "Q7JQR3", "FBgn0033814", "Q95TL8", "FBgn0030734", "Q94527", "Rel", "Q9VH14", "FBgn0025879", "Q9VF87", "FBgn0038320", "Q23997", "FBgn0013763", "Q9W303", "FBgn0026415", "Q9VZV2", "FBgn0035398", "Q9V3D4", "FBgn0020415", "Q8T0R7", "FBgn0064237", "Q8MM24", "FBgn0020416", "Q8MLZ7", "FBgn0020414", "Q7KUC2", "FBgn0085484", "Q9VJQ0", "FBgn0028888", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "A1Z9N6", "FBgn0261269", "Q7K485", "FBgn0029093", "Q9W122", "FBgn0035049", "Q9VG73", "FBgn0038046", "Q8IQM9", "FBgn0263607", "X2JAR4", "FBgn0261848", "Q9VZI1", "FBgn0035499", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "P13395", "FBgn0250789", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "O46037", "FBgn0004397", "Q9VWZ7", "FBgn0030887", "Q9VE79", "FBgn0038611", "Q9VHE4", "FBgn0037687", "Q9W4K2", "FBgn0029708", "Q9V9J3", "phospho-Src42A", "O76895", "FBgn0023535", "P29349", "FBgn0000382", "Q9VB21", "FBgn0039527", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "P18824", "arm", "Q9W0M1", "FBgn0035168", "O76901", "FBgn0025382", "Q9VGN8", "FBgn0037900", "Q7KRY7", "FBgn0263289", "Q86PD7", "FBgn0036999", "O18388", "FBgn0262743" ] }, "reaction_10484598": { "compartment": "compartment_6799351", "id": "reaction_10484598", "reactome": "R-DME-6799350", "name": "Exocytosis of specific granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484554" ], "products": [ "species_10484596" ], "modifiers": [], "additional_components": [ "Q9W179", "FBgn0035001", "Q9VIG0", "FBgn0032916", "Q9VYJ4", "FBgn0030421", "O62531", "FBgn0024833", "Q9VXM4", "FBgn0030703", "B7YZF8", "FBgn0259221", "P09478", "FBgn0000036", "Q9VGD4", "FBgn0037989", "M9PHI0", "FBgn0263220", "P12080", "FBgn0001250", "Q9VWE0", "dome", "Q9VXG0", "FBgn0030752", "O96692", "FBgn0283666", "Q94515", "FBgn0001941", "Q9VW73", "FBgn0036932", "B7YZT5", "FBgn0286511", "Q9VMJ6", "FBgn0031760", "Q9VAP3", "FBgn0039637", "Q6NP91", "FBgn0033259", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999", "Q9VH76", "FBgn0266720", "P36975", "FBgn0011288", "Q8IRI6", "FBgn0264574", "E1JI63", "FBgn0035815", "Q9NBC8", "FBgn0039595", "A1Z7G7", "FBgn0033313", "Q9VA10", "FBgn0039821", "Q8SZ78", "FBgn0039818", "Q9VGJ9", "FBgn0037933", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "Q9VXD1", "FBgn0261245", "Q9W4B6", "FBgn0029771", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9VLT5", "FBgn0011230", "P35992", "FBgn0004370", "Q960U8", "FBgn0004797", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "Q9VJW9", "FBgn0259984", "Q8MPP3", "FBgn0033438", "P08645", "FBgn0004636", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140", "Q9VZA4", "FBgn0260657", "Q9VXV6", "FBgn0040285", "M9PE71", "FBgn0013342", "P18489", "FBgn0003660", "Q9V7D2", "FBgn0022097", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "Q7KK97", "FBgn0028563", "Q9W4F7", "FBgn0029737", "Q9V8I2", "FBgn0034350", "Q9VJD2", "FBgn0032642", "Q9VSZ1", "FBgn0035995", "Q8SY02", "FBgn0051634", "Q03751", "FBgn0004179", "Q9VP04", "FBgn0037110", "M9PBR6", "FBgn0053523", "A1Z7G7", "FBgn0033313", "Q9VA10", "FBgn0039821", "Q8SZ78", "FBgn0039818", "Q9VGJ9", "FBgn0037933", "M9PBR6", "FBgn0053523", "E1JI63", "FBgn0035815", "Q9VIG0", "FBgn0032916", "Q8IRI6", "FBgn0264574", "Q9VXM4", "FBgn0030703", "Q9W179", "FBgn0035001", "Q9V7D2", "FBgn0022097", "Q9VXV6", "FBgn0040285", "P11584", "FBgn0004657", "Q27591", "FBgn0010395", "P12080", "FBgn0001250", "Q8SY02", "FBgn0051634", "Q9VSZ1", "FBgn0035995", "P09478", "FBgn0000036", "Q9W4B6", "FBgn0029771", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "Q9VXD1", "FBgn0261245", "Q9VYJ4", "FBgn0030421", "Q9NBC8", "FBgn0039595", "O62531", "FBgn0024833", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "Q94515", "FBgn0001941", "Q9VLT5", "FBgn0011230", "Q960U8", "FBgn0004797", "P35992", "FBgn0004370", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q9VGD4", "FBgn0037989", "Q8SXR7", "FBgn0034999", "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "B7YZT5", "FBgn0286511", "Q03751", "FBgn0004179", "Q9VP04", "FBgn0037110", "B7YZF8", "FBgn0259221", "Q9VJW9", "FBgn0259984", "M9PHI0", "FBgn0263220", "Q9VXG0", "FBgn0030752", "Q9VW73", "FBgn0036932", "Q7KK97", "FBgn0028563", "Q9VZA4", "FBgn0260657", "Q8MPP3", "FBgn0033438", "Q9VAP3", "FBgn0039637", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q9V8I2", "FBgn0034350", "Q9VJD2", "FBgn0032642", "O96692", "FBgn0283666", "Q6NP91", "FBgn0033259", "Q9VMJ6", "FBgn0031760", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q9W4F7", "FBgn0029737", "Q9VWE0", "dome", "P08645", "FBgn0004636", "X2JE21", "FBgn0259110", "Q6QU65", "FBgn0265140" ] }, "reaction_10481684": { "compartment": "compartment_6798757", "id": "reaction_10481684", "reactome": "R-DME-6798739", "name": "Exocytosis of azurophil granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481590" ], "products": [ "species_10481682" ], "modifiers": [], "additional_components": [ "Q9VXG0", "FBgn0030752", "Q9VIM0", "FBgn0032864", "Q9VXD1", "FBgn0261245", "Q9W4B6", "FBgn0029771", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "P23380", "FBgn0262736", "Q9VSZ1", "FBgn0035995", "O02194", "FBgn0284421", "Q8SY02", "FBgn0051634", "Q9W1I8", "FBgn0034913", "Q9VC27", "FBgn0039234", "Q9VQM2", "FBgn0031505", "Q7JYV2", "FBgn0033876", "Q8SY19", "FBgn0025814", "Q8SY53", "FBgn0032015", "A1Z959", "FBgn0050486", "Q9VHJ0", "FBgn0037650", "Q8IRK1", "FBgn0264297", "Q9W129", "FBgn0035042", "A8WHB7", "FBgn0054049", "Q9VIN6", "FBgn0032853", "O18405", "FBgn0019925", "Q9VLH1", "FBgn0032074", "Q9V3I2", "FBgn0014010", "Q9V9S0", "FBgn0032949", "P25228", "FBgn0005586", "Q9VZP9", "FBgn0035444", "Q9VD68", "FBgn0038912", "Q9VW01", "FBgn0036877", "Q8I0P9", "FBgn0000032", "Q9VW00", "FBgn0036876", "B7Z080", "FBgn0036875", "Q9VQ86", "FBgn0031397", "Q9VMY5", "FBgn0037215", "Q7KN92", "FBgn0027538", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "P08645", "FBgn0004636", "Q9VHV5", "FBgn0037551", "Q0KHU5", "FBgn0052699", "B7YZF8", "FBgn0259221", "Q24319", "FBgn0014868", "Q9VZA4", "FBgn0260657", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q03751", "FBgn0004179", "A1Z7S0", "FBgn0015477", "Q9VW73", "FBgn0036932", "Q9Y125", "FBgn0000416", "Q03751", "FBgn0004179", "Q9VQM2", "FBgn0031505", "Q8SY19", "FBgn0025814", "A1Z959", "FBgn0050486", "Q9W129", "FBgn0035042", "Q9VIN6", "FBgn0032853", "Q9VHJ0", "FBgn0037650", "Q8IRK1", "FBgn0264297", "A8WHB7", "FBgn0054049", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "A1Z7S0", "FBgn0015477", "Q24319", "FBgn0014868", "Q9VZA4", "FBgn0260657", "Q9W4B6", "FBgn0029771", "Q9VZ71", "FBgn0030234", "Q9VYX8", "FBgn0030309", "Q9VXD1", "FBgn0261245", "Q9VW73", "FBgn0036932", "Q9VLH1", "FBgn0032074", "Q9VHV5", "FBgn0037551", "Q9VXG0", "FBgn0030752", "Q9VXG7", "FBgn0030746", "Q9VXG6", "FBgn0030747", "O02194", "FBgn0284421", "P23380", "FBgn0262736", "Q9VMY5", "FBgn0037215", "Q9VSZ1", "FBgn0035995", "Q0KHU5", "FBgn0052699", "Q7JYV2", "FBgn0033876", "Q9V9S0", "FBgn0032949", "Q9W1I8", "FBgn0034913", "Q9VZP9", "FBgn0035444", "Q8SY02", "FBgn0051634", "O18405", "FBgn0019925", "Q9V3I2", "FBgn0014010", "P25228", "FBgn0005586", "Q9VC27", "FBgn0039234", "Q9Y125", "FBgn0000416", "Q9VIM0", "FBgn0032864", "B7YZF8", "FBgn0259221", "Q8SY53", "FBgn0032015", "Q9VW01", "FBgn0036877", "Q9VW00", "FBgn0036876", "Q9VQ86", "FBgn0031397", "Q9VD68", "FBgn0038912", "Q8I0P9", "FBgn0000032", "B7Z080", "FBgn0036875", "P08645", "FBgn0004636", "Q7KN92", "FBgn0027538" ] }, "reaction_10484242": { "compartment": "compartment_1470028", "id": "reaction_10484242", "reactome": "R-DME-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10484040" ], "products": [ "species_10484240" ], "modifiers": [], "additional_components": [ "A1Z8C9", "FBgn0050016", "Q9VQX4", "FBgn0031589", "Q7KN62", "FBgn0286784", "Q8WSF3", "FBgn0045063", "Q0E8H9", "FBgn0041630", "Q9W3C4", "FBgn0041629", "Q8IQM9", "FBgn0263607", "Q7JYA0", "FBgn0033873", "Q9VWE8", "FBgn0031050", "Q9VRP2", "FBgn0035630", "Q9V420", "FBgn0004465", "Q9VEK7", "FBgn0025456", "P83099", "FBgn0259680", "A1ZBX7", "FBgn0034539", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q9VQI7", "FBgn0031479", "Q9VS41", 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homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10482267" ], "products": [ "species_10482367" ], "modifiers": [], "additional_components": [ "Q9VH14", "FBgn0025879", "P13395", "FBgn0250789", "Q9VTP0", "FBgn0259140", "Q9VHE4", "FBgn0037687", "Q9VZI1", "FBgn0035499", "Q9V3D4", "FBgn0020415", "Q8T0R7", "FBgn0064237", "Q8MM24", "FBgn0020416", "Q8MLZ7", "FBgn0020414", "Q23997", "FBgn0013763", "Q9W303", "FBgn0026415", "Q9VZV2", "FBgn0035398", "Q9VJ39", "FBgn0032721", "Q9VWZ7", "FBgn0030887", "Q9VUY9", "FBgn0003076", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9VYH1", "FBgn0030449", "X2JAR4", "FBgn0261848", "Q9VU84", "FBgn0036372", "Q9VLR3", "FBgn0032001", "P29349", "FBgn0000382", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q8IQM9", "FBgn0263607", "Q9VGN8", "FBgn0037900", "Q9VG73", "FBgn0038046", "Q7JQR3", "FBgn0033814", "Q9VNK6", "FBgn0037396", "Q9W4K2", "FBgn0029708", "Q7K485", "FBgn0029093", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "Q9VJQ0", "FBgn0028888", "A1Z9N6", "FBgn0261269", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "Q9XZF0", "FBgn0026749", "Q9W122", "FBgn0035049", "Q86PD7", "FBgn0036999", "B7Z0E0", "FBgn0001248", "Q9VF87", "FBgn0038320", "B7Z0E0", "FBgn0001248", "Q7JQR3", "FBgn0033814", "Q9VF87", "FBgn0038320", "Q9VH14", "FBgn0025879", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q9VYH1", "FBgn0030449", "Q9VU84", "FBgn0036372", "Q9VNK6", "FBgn0037396", "Q9VLR3", "FBgn0032001", "Q9VJQ0", "FBgn0028888", "Q9VHV3", "FBgn0037552", "Q7JWP9", "FBgn0034717", "Q01819", "FBgn0005775", "A1Z9N6", "FBgn0261269", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9W122", "FBgn0035049", "Q7K485", "FBgn0029093", "Q9VG73", "FBgn0038046", "Q8IQM9", "FBgn0263607", "X2JAR4", "FBgn0261848", "Q9VZI1", "FBgn0035499", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VTP0", "FBgn0259140", "Q9VUY9", "FBgn0003076", "Q9VJ39", "FBgn0032721", "P13395", "FBgn0250789", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "Q9VWZ7", "FBgn0030887", "Q9VHE4", "FBgn0037687", "Q9W4K2", "FBgn0029708", "Q9XZF0", "FBgn0026749", "P29349", "FBgn0000382", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "Q9VGN8", "FBgn0037900", "Q86PD7", "FBgn0036999", "Q8T0R7", "FBgn0064237", "Q9W303", "FBgn0026415", "Q8MM24", "FBgn0020416", "Q9VZV2", "FBgn0035398", "Q8MLZ7", "FBgn0020414", "Q9V3D4", "FBgn0020415", "Q23997", "FBgn0013763" ] }, "reaction_10485728": { "compartment": "compartment_984", "id": "reaction_10485728", "reactome": "R-DME-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485116" ], "products": [ "species_10485198" ], "modifiers": [], "additional_components": [ "Q9VIM0", "FBgn0032864", "Q9VM64", "ihog", "A8JUV7", "FBgn0040388", "P23380", "FBgn0262736", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "P49283", "FBgn0011672", "Q27591", "FBgn0010395", "P11584", "FBgn0004657", "P55162", "FBgn0011771", "Q9VHM2", "FBgn0037622", "Q9VLT5", "FBgn0011230", "Q9VLL4", 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"FBgn0259110", "Q6QU65", "FBgn0265140" ] }, "reaction_10482080": { "compartment": "compartment_876", "id": "reaction_10482080", "reactome": "R-DME-6798743", "name": "Exocytosis of secretory granule membrane proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481912" ], "products": [ "species_10482078" ], "modifiers": [], "additional_components": [ "O18334", "Rab6", "Q7KK97", "FBgn0028563", "Q9XZ10", "FBgn0028671", "Q8IQC6", "FBgn0052039", "Q9VEX6", "FBgn0287225", "Q9V3I2", "FBgn0014010", "Q7KY04", "FBgn0016701", "P91926", "FBgn0264855", "Q7KN92", "FBgn0027538", "A1Z7S0", "FBgn0015477", "P25228", "FBgn0005586", "Q9VP04", "FBgn0037110", "Q9W4A0", "FBgn0015794", "P45437", "FBgn0008635", "O15971", "FBgn0015789", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "P40792", "RAC1_DROME", "Q9VIW6", "FBgn0032782", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q9VPH1", "FBgn0036978", "Q9VPU6", "FBgn0031289", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "P55162", "FBgn0011771", "Q7KRW4", "FBgn0039640", "Q9VLL4", "FBgn0032042", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "P48608", "FBgn0011202", "Q9VZ20", "FBgn0030276", "Q9W5Y0", "FBgn0031081", "P12080", "FBgn0001250", "P48148", "Rho1", "Q09101", "FBgn0010114", "Q9VYR4", "FBgn0001083", "O76742", "FBgn0015795", "Q9W5Y0", "FBgn0031081", "Q9VS89", "FBgn0035798", "Q9VPJ0", "FBgn0031217", "A1Z6W9", "FBgn0003174", "Q7KRW4", "FBgn0039640", "P48148", "Rho1", "P25228", "FBgn0005586", "O76742", "FBgn0015795", "O18334", "Rab6", "P91926", "FBgn0264855", "A1Z7S0", "FBgn0015477", "Q9V3I2", "FBgn0014010", "Q9VYR4", "FBgn0001083", "Q09101", "FBgn0010114", "Q7KY04", "FBgn0016701", "Q7KK97", "FBgn0028563", "Q9W4A0", "FBgn0015794", "O15971", "FBgn0015789", "Q9VIW6", "FBgn0032782", "Q9VPH1", "FBgn0036978", "Q9VPU6", "FBgn0031289", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q8IQC6", "FBgn0052039", "P55162", "FBgn0011771", "Q9VLL4", "FBgn0032042", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "P48608", "FBgn0011202", "Q9VZ20", "FBgn0030276", "Q9XZ10", "FBgn0028671", "Q9VEX6", "FBgn0287225", "Q9VP04", "FBgn0037110", "P12080", "FBgn0001250", "P45437", "FBgn0008635", "A1Z8L7", "FBgn0040503", "Q9VPS2", "FBgn0040107", "A1Z7Z6", "FBgn0040093", "Q9VPS1", "FBgn0040106", "Q9VM16", "FBgn0031910", "Q9VLM0", "FBgn0040098", "Q9VKL8", "FBgn0040096", "Q9VIX1", "FBgn0016675", "Q8IRH8", "FBgn0035199", "Q7JY62", "FBgn0040092", "Q59DY6", "FBgn0053532", "Q59DY5", "FBgn0053533", "M9PB26", "FBgn0264341", "M9NE79", "FBgn0262357", "C3KGN2", "FBgn0283508", "Q9W3D8", "FBgn0030050", "B7Z0K3", "FBgn0038315", "Q9VQX3", "FBgn0040102", "B7YZU7", "FBgn0259230", "Q9VQU4", "FBgn0040104", "B4ZJ93", "FBgn0259958", "Q9VQ53", "FBgn0031373", "P40792", "RAC1_DROME", "Q7KN92", "FBgn0027538" ] }, "reaction_10493472": { "compartment": "compartment_70101", "id": "reaction_10493472", "reactome": "R-DME-8948039", "name": "FUNDC1 is phosphorylated by CK2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493467", "species_113592" ], "products": [ "species_10493470", "species_29370" ], "modifiers": [ [ "species_10441790", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "P08182", "CkIIbeta", "P08181", "CkIIalpha" ] }, "reaction_10493490": { "compartment": "compartment_70101", "id": "reaction_10493490", "reactome": "R-DME-8948143", "name": "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493470", "species_113592" ], "products": [ "species_10493487", "species_29370" ], "modifiers": [ [ "species_10440003", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "FBgn0262733" ] }, "reaction_10493476": { "compartment": "compartment_17906", "id": "reaction_10493476", "reactome": "R-DME-8948136", "name": "ULK1 Translocates to the mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475486" ], "products": [ "species_10493474" ], "modifiers": [], "additional_components": [ "FBgn0260945", "FBgn0260945" ] }, "reaction_10493496": { "compartment": "compartment_17906", "id": "reaction_10493496", "reactome": "R-DME-8948146", "name": "FUNDC1 is phosphorylated by ULK1 at Ser17", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493467", "species_113592" ], "products": [ "species_29370", "species_10493493" ], "modifiers": [ [ "species_10493474", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "FBgn0260945" ] }, "reaction_10493484": { "compartment": "compartment_70101", "id": "reaction_10493484", "reactome": "R-DME-8948139", "name": "p-S13-FUNDC1 is dephosphorylated by PGAM5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493470" ], "products": [ "species_10493467" ], "modifiers": [ [ "species_10493481", "catalyst" ] ], "additional_components": [ "FBgn0032200", "FBgn0032200", "FBgn0023517" ] }, "reaction_10470847": { "compartment": "compartment_17906", "id": "reaction_10470847", "reactome": "R-DME-5205682", "name": "Parkin promotes the ubiquitination of mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457377", "species_10457379", "species_10470842", "species_10426987", "species_10470844" ], "products": [ "species_10470752", "species_10470784", "species_10470758", "species_10470745" ], "modifiers": [ [ "species_10470798", "catalyst" ] ], "additional_components": [ "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "FBgn0029870", "Q9VKP4", "FBgn0260453", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q94920", "FBgn0004363", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0037008", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "FBgn0037008", "FBgn0029870", "Q0KHV6", "FBgn0029891", "Q7KTX7", "FBgn0041100" ] }, "reaction_10470828": { "compartment": "compartment_70101", "id": "reaction_10470828", "reactome": "R-DME-5205673", "name": "p62 binds ubiquitinated mitochondrial substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470784", "species_10470752", "species_10470789", "species_10470758", "species_10470745" ], "products": [ "species_10470791" ], "modifiers": [], "additional_components": [ "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q7YU24", "FBgn0029870", "O18412", "FBgn0011596", "FBgn0003231", "FBgn0037008", "FBgn0029870", "Q7YU24", "FBgn0029870", "Q9VPD5", "FBgn0037008", "P14199", "FBgn0003231", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354" ] }, "reaction_10470826": { "compartment": "compartment_17906", "id": "reaction_10470826", "reactome": "R-DME-5205672", "name": "Uncleaved Pink1 accumulates in damaged mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470804" ], "products": [ "species_10470796" ], "modifiers": [], "additional_components": [ "FBgn0029891", "FBgn0029891" ] }, "reaction_10470824": { "compartment": "compartment_21994", "id": "reaction_10470824", "reactome": "R-DME-5205663", "name": "LC3 binds the autophagosome membrane Atg5-Atg12 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470816", "species_10470820" ], "products": [ "species_10470822" ], "modifiers": [], "additional_components": [ "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "Q7YU24", "FBgn0029870", "Q9VPD5", "FBgn0037008", "P14199", "FBgn0003231", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q7YU24", "FBgn0029870", "Q9VPD5", "FBgn0037008", "P14199", "FBgn0003231", "O18412", "FBgn0011596", "Q9VKP4", "FBgn0260453", "Q94920", "FBgn0004363", "Q9VKP3", "FBgn0260454", "Q9VKP2", "FBgn0069354", "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255" ] }, "reaction_10470832": { "compartment": "compartment_17927", "id": "reaction_10470832", "reactome": "R-DME-5205681", "name": "Pink1 is cleaved on healthy mitochondria", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470804" ], "products": [ "species_10470830" ], "modifiers": [], "additional_components": [ "FBgn0029891", "FBgn0029891" ] }, "reaction_10470800": { "compartment": "compartment_17906", "id": "reaction_10470800", "reactome": "R-DME-5205652", "name": "Pink1 recruits Parkin to the outer mitochondrial membrane.", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10456711", "species_10470796" ], "products": [ "species_10470798" ], "modifiers": [], "additional_components": [ "FBgn0041100", "FBgn0029891", "Q0KHV6", "FBgn0029891", "Q7KTX7", "FBgn0041100" ] }, "reaction_10498066": { "compartment": "compartment_70101", "id": "reaction_10498066", "reactome": "R-DME-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498064" ], "products": [ "species_10498062", "species_10498041" ], "modifiers": [], "additional_components": [ "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10498039": { "compartment": "compartment_70101", "id": "reaction_10498039", "reactome": "R-DME-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498013", "species_10498035" ], "products": [ "species_10498037" ], "modifiers": [], "additional_components": [ "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10498122": { "compartment": "compartment_70101", "id": "reaction_10498122", "reactome": "R-DME-9646348", "name": "PolyUb-Misfolded Proteins:HDAC6 bind dynein motor", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498118", "species_10473486" ], "products": [ "species_10498120" ], "modifiers": [], "additional_components": [ "M9PJN5", "FBgn0026428", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "M9PJN5", "FBgn0026428", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802" ] }, "reaction_10498091": { "compartment": "compartment_70101", "id": "reaction_10498091", "reactome": "R-DME-9641111", "name": "Parkin transfers Ub to misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498037" ], "products": [ "species_10498089" ], "modifiers": [], "additional_components": [ "Q9VA37", "FBgn0039802", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q400N2", "FBgn0086690", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q9VA37", "FBgn0039802", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10498093": { "compartment": "compartment_70101", "id": "reaction_10498093", "reactome": "R-DME-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498089" ], "products": [ "species_10498064" ], "modifiers": [], "additional_components": [ "Q400N2", "FBgn0086690", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q9VA37", "FBgn0039802", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "Q7KTX7", "FBgn0041100", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "M9PGG8", "FBgn0040010", "Q8T415", "FBgn0051802", "Q7KRS6", "FBgn0016919", "Q400N2", "FBgn0086690", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGM1", "FBgn0263316", "Q9VJ21", "FBgn0051793", "P91660", "FBgn0010549", "Q9VLN6", "FBgn0032026", "Q7KT22", "FBgn0032908", "Q9W2I5", "FBgn0034612", "Q8MT77", "FBgn0051793", "Q961D3", "FBgn0039644", "Q9VAN4", "FBgn0039645", "Q9VC63", "FBgn0039207", "Q9VA37", "FBgn0039802" ] }, "reaction_10498015": { "compartment": "compartment_70101", "id": "reaction_10498015", "reactome": "R-DME-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498011", "species_10456711" ], "products": [ "species_10498013" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A", "FBgn0041100", "Q7KTX7", "FBgn0041100", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VJS5", "FBgn0028913", "Q9VGD6", "FBgn0037987", "P35128", "ben", "Q9VRL1", "Uev1A" ] }, "reaction_10476379": { "compartment": "compartment_70101", "id": "reaction_10476379", "reactome": "R-DME-5683593", "name": "ATG7:ATG3:LC3 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476267" ], "products": [ "species_10476252", "species_10476207" ], "modifiers": [], "additional_components": [ "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539" ] }, "reaction_10476250": { "compartment": "compartment_70101", "id": "reaction_10476250", "reactome": "R-DME-5679266", "name": "Beclin-1 complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460755" ], "products": [ "species_10476237" ], "modifiers": [], "additional_components": [ "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325" ] }, "reaction_10476377": { "compartment": "compartment_70101", "id": "reaction_10476377", "reactome": "R-DME-5682896", "name": "LC3:ATG7 dimer binds ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476211", "species_10476263" ], "products": [ "species_10476265" ], "modifiers": [], "additional_components": [ "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813" ] }, "reaction_10476248": { "compartment": "compartment_70101", "id": "reaction_10476248", "reactome": "R-DME-5679255", "name": "WIPI2 binds ATG12:ATG5:ATG16L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476225", "species_10476227" ], "products": [ "species_10476229" ], "modifiers": [], "additional_components": [ "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "B7Z0R7", "FBgn0039705", "species_1806289", "M9PER1", "FBgn0035850", "species_1806289", "M9PER1", "FBgn0035850", "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "B7Z0R7", "FBgn0039705" ] }, "reaction_10476246": { "compartment": "compartment_70101", "id": "reaction_10476246", "reactome": "R-DME-5679239", "name": "ULK complex translocates to the ER", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476100" ], "products": [ "species_10460794" ], "modifiers": [], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960", "Q7KTS2", "FBgn0037363", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10476244": { "compartment": "compartment_70101", "id": "reaction_10476244", "reactome": "R-DME-5679206", "name": "MTMR14, MTMR3 dephosphorylate PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5676030" ], "products": [ "species_426639" ], "modifiers": [ [ "species_10476241", "catalyst" ] ], "additional_components": [ "Q7YU03", "FBgn0030735", "A1ZAS8", "FBgn0027506" ] }, "reaction_10475727": { "compartment": "compartment_70101", "id": "reaction_10475727", "reactome": "R-DME-5672817", "name": "Active MTORC1 binds the ULK1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040", "species_10475494" ], "products": [ "species_10475696" ], "modifiers": [], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10476239": { "compartment": "compartment_70101", "id": "reaction_10476239", "reactome": "R-DME-5679205", "name": "ULK1 phosphorylates Beclin-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10476237" ], "products": [ "species_10475715", "species_29370" ], "modifiers": [ [ "species_10460794", "catalyst" ] ], "additional_components": [ "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475724": { "compartment": "compartment_17938", "id": "reaction_10475724", "reactome": "R-DME-5672017", "name": "Rheb in the MTORC1 complex hydrolyses GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437040" ], "products": [ "species_10445903" ], "modifiers": [ [ "species_10437040", "catalyst" ], [ "species_10475722", "catalyst" ] ], "additional_components": [ "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VCC9", "FBgn0026317", "Q9VW83", "FBgn0005198" ] }, "reaction_10476299": { "compartment": "compartment_70101", "id": "reaction_10476299", "reactome": "R-DME-5682011", "name": "LC3 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476199", "species_10476252" ], "products": [ "species_10476263" ], "modifiers": [], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366" ] }, "reaction_10476297": { "compartment": "compartment_70101", "id": "reaction_10476297", "reactome": "R-DME-5681987", "name": "LC3 is cleaved by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476278" ], "products": [ "species_10476199" ], "modifiers": [ [ "species_10476294", "catalyst" ] ], "additional_components": [ "Q9VEG5", "FBgn0038539", "Q9W2S2", "FBgn0052672", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q9VPW2", "FBgn0031298" ] }, "reaction_10476232": { "compartment": "compartment_70101", "id": "reaction_10476232", "reactome": "R-DME-5678490", "name": "ATG16L1 complex transfers LC3 from ATG3 to PE", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5681998", "species_10476207" ], "products": [ "species_10476209", "species_10476211" ], "modifiers": [ [ "species_10476229", "catalyst" ] ], "additional_components": [ "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "species_1602375", "FBgn0036813", "species_1806289", "M9PER1", "FBgn0035850", "Q9W3R7", "FBgn0029943", "Q9VTU1", "FBgn0036255", "B7Z0R7", "FBgn0039705" ] }, "reaction_10476103": { "compartment": "compartment_70101", "id": "reaction_10476103", "reactome": "R-DME-5675868", "name": "ULK1 phosphorylates ATG13 and RB1CC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475691" ], "products": [ "species_10476100", "species_29370" ], "modifiers": [ [ "species_10475691", "catalyst" ] ], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960", "Q7KTS2", "FBgn0037363", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475718": { "compartment": "compartment_12045", "id": "reaction_10475718", "reactome": "R-DME-5672012", "name": "Beclin-1 complex phosphorylates PtdIns", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_426639" ], "products": [ "species_29370", "species_5676030" ], "modifiers": [ [ "species_10475715", "catalyst" ] ], "additional_components": [ "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325" ] }, "reaction_10460797": { "compartment": "compartment_70101", "id": "reaction_10460797", "reactome": "R-DME-1632857", "name": "ULK1 phosphorylates AMBRA1:BECN1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460757", "species_113592" ], "products": [ "species_29370", "species_10460763" ], "modifiers": [ [ "species_10460794", "catalyst" ] ], "additional_components": [ "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q8MQJ7", "FBgn0260945", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475708": { "compartment": "compartment_70101", "id": "reaction_10475708", "reactome": "R-DME-5672011", "name": "p-AMPK:AMP binds the ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475494", "species_10445887" ], "products": [ "species_10475496" ], "modifiers": [], "additional_components": [ "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10476091": { "compartment": "compartment_74700", "id": "reaction_10476091", "reactome": "R-DME-5675790", "name": "MTORC1 dissociates from ULK complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475946" ], "products": [ "species_10475701", "species_10437109" ], "modifiers": [], "additional_components": [ "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691" ] }, "reaction_10476347": { "compartment": "compartment_5683628", "id": "reaction_10476347", "reactome": "R-DME-5682388", "name": "Autophagosome maturation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476209" ], "products": [ "species_10476338" ], "modifiers": [ [ "species_10476345", "catalyst" ], [ "species_10454980", "catalyst" ] ], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "species_1602375", "species_1602375", "Q9VEG5", "FBgn0038539", "Q9W2S2", "FBgn0052672", "Q9W1M7", "FBgn0015277", "Q9VK07", "FBgn0032499", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9Y124", "FBgn0027565", "Q8T0Q4", "FBgn0086656", "Q9VN02", "FBgn0037231", "Q9VRJ5", "FBgn0035589", "Q9VBI3", "FBgn0039402", "Q9W236", "FBgn0034744" ] }, "reaction_10475706": { "compartment": "compartment_17938", "id": "reaction_10475706", "reactome": "R-DME-5672010", "name": "Active MTORC1 phosphorylates ULK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475696", "species_113592" ], "products": [ "species_29370", "species_10475703" ], "modifiers": [ [ "species_10475696", "catalyst" ] ], "additional_components": [ "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb" ] }, "reaction_10476407": { "compartment": "compartment_70101", "id": "reaction_10476407", "reactome": "R-DME-5683925", "name": "ULK1 is dephosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475701" ], "products": [ "species_29372", "species_10475494" ], "modifiers": [], "additional_components": [ "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475505": { "compartment": "compartment_70101", "id": "reaction_10475505", "reactome": "R-DME-5665868", "name": "AMPK (complex) phosphorylates ULK1 (complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475496" ], "products": [ "species_29370", "species_10475502" ], "modifiers": [ [ "species_10475496", "catalyst" ] ], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10475694": { "compartment": "compartment_70101", "id": "reaction_10475694", "reactome": "R-DME-5672008", "name": "Thr-180 of ULK1 is phosphorylated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475502" ], "products": [ "species_29370", "species_10475691" ], "modifiers": [ [ "species_10475502", "catalyst" ] ], "additional_components": [ "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169", "Q8MQJ7", "FBgn0260945", "Q7KTS2", "FBgn0037363", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960" ] }, "reaction_10476270": { "compartment": "compartment_70101", "id": "reaction_10476270", "reactome": "R-DME-5681981", "name": "ATG3 transfers LC3 from ATG7 to ATG3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476265" ], "products": [ "species_10476267" ], "modifiers": [ [ "species_10476265", "catalyst" ] ], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813", "Q9VVS6", "FBgn0036813", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q7JY94", "FBgn0034366", "Q9VVS6", "FBgn0036813" ] }, "reaction_10475948": { "compartment": "compartment_70101", "id": "reaction_10475948", "reactome": "R-DME-5673768", "name": "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10475703" ], "products": [ "species_29370", "species_10475946" ], "modifiers": [ [ "species_10445887", "catalyst" ] ], "additional_components": [ "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29438", "species_29420", "Q7K519", "FBgn0033272", "Q9VND8", "Rheb", "Q9VND8", "Rheb", "species_29438", "Q9V8I2", "FBgn0034350", "O96824", "FBgn0026090", "Q9VW73", "FBgn0036932", "Q9VZL6", "FBgn0035469", "Q9VJD2", "FBgn0032642", "Q9VHJ4", "FBgn0037647", "species_29420", "Q7K519", "FBgn0033272", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691", "Q7KTS2", "FBgn0037363", "Q8MQJ7", "FBgn0260945", "Q9VHR6", "FBgn0261108", "Q9VWQ1", "FBgn0030960", "species_76577", "Q9VDD2", "FBgn0264357", "A1Z7Q8", "FBgn0260972", "O18645", "FBgn0023169" ] }, "reaction_10496854": { "compartment": "compartment_70101", "id": "reaction_10496854", "reactome": "R-DME-9020616", "name": "ATG12 forms a thioester bond with ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476254" ], "products": [ "species_10476375" ], "modifiers": [], "additional_components": [ "Q7JY94", "FBgn0034366", "Q9VTU1", "FBgn0036255", "Q9VTU1", "FBgn0036255", "Q7JY94", "FBgn0034366" ] }, "reaction_10476328": { "compartment": "compartment_12045", "id": "reaction_10476328", "reactome": "R-DME-5682385", "name": "The phagophore extends from the PIP3-enriched structure", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475715" ], "products": [ "species_10476326" ], "modifiers": [], "additional_components": [ "Q9VAP6", "FBgn0039636", "Q9W1M7", "FBgn0015277", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325", "Q9W1M7", "FBgn0015277", "Q9VAP6", "FBgn0039636", "Q9VHH2", "FBgn0260935", "Q9VCE1", "FBgn0264325" ] }, "reaction_10476322": { "compartment": "compartment_70101", "id": "reaction_10476322", "reactome": "R-DME-5682377", "name": "LC3 de-lipidation by ATG4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476209" ], "products": [ "species_5681998", "species_10476199" ], "modifiers": [ [ "species_10476294", "catalyst" ] ], "additional_components": [ "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "species_1602375", "Q9W2S2", "FBgn0052672", "Q9VEG5", "FBgn0038539", "Q9VPW2", "FBgn0031298" ] }, "reaction_10476128": { "compartment": "compartment_70101", "id": "reaction_10476128", "reactome": "R-DME-5676229", "name": "WIPIs bind PI3P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693050", "species_10476124" ], "products": [ "species_10476126" ], "modifiers": [], "additional_components": [ "M9PER1", "FBgn0035850", "Q9VIE1", "FBgn0032935", "M9PER1", "FBgn0035850", "Q9VIE1", "FBgn0032935", "species_1806198" ] }, "reaction_10476256": { "compartment": "compartment_70101", "id": "reaction_10476256", "reactome": "R-DME-5681980", "name": "ATG12 binds ATG7 dimer", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476218", "species_10476252" ], "products": [ "species_10476254" ], "modifiers": [], "additional_components": [ "FBgn0036255", "Q7JY94", "FBgn0034366", "Q7JY94", "FBgn0034366", "Q9VTU1", "FBgn0036255" ] }, "reaction_350436": { "compartment": "compartment_70101", "id": "reaction_350436", "reactome": "R-DME-350436", "name": "DGO binds to DSH", "reversible": "false", "notes": "Diego (DGO) binding to Dishevelled (DSH) enhances Frizzled (FZ) PCP signalling. DGO, like FZ is required in R3/Distal cell fate. DGO binds to PDZ domain of DSH. DGO binding to DSH protects it from (Prickle) PK binding and its antagonistic effects. DGO could help promote DSH activation via stimulation of its phosphorylation.", "reactants": [ "species_450795", "species_351073" ], "products": [ "species_450734" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK" ] }, "reaction_350486": { "compartment": "compartment_70101", "id": "reaction_350486", "reactome": "R-DME-350486", "name": "DSH binds to FZ at the plasma membrane", "reversible": "false", "notes": "In the cytosol, the PDZ domain of Dishevelled (DSH) binds to the transmembrane receptor Frizzled (FZ) at the plasma membrane.", "reactants": [ "species_450698", "species_205749" ], "products": [ "species_450779" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "Q9V5N8", "STAN", "P18537", "FZ", "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ" ] }, "reaction_350408": { "compartment": "compartment_70101", "id": "reaction_350408", "reactome": "R-DME-350408", "name": "PK binds to VANG at the plasma membrane", "reversible": "false", "notes": "C-terminal region of Vang Gogh (VANG) binds to a C-terminal region of Prickle (PK). Both VANG and PK are both able to bind to themselves in the same regions.", "reactants": [ "species_351050", "species_450779" ], "products": [ "species_450795" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "O45030", "VANG", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK" ] }, "reaction_10493702": { "compartment": "compartment_7660", "id": "reaction_10493702", "reactome": "R-DME-8951676", "name": "RUNX3 binds TEADs and YAP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10464533", "species_10489801" ], "products": [ "species_10493700" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd", "FBgn0083981", "M9PI08", "FBgn0083981", "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_390133": { "compartment": "compartment_13231", "id": "reaction_390133", "reactome": "R-DME-390133", "name": "YKI transports from the cytosol to the nucleus", "reversible": "false", "notes": "The transcription factor Yorkie (YKI) translocates from the cytosol to the nucleus.", "reactants": [ "species_390114" ], "products": [ "species_390143" ], "modifiers": [], "additional_components": [] }, "reaction_390184": { "compartment": "compartment_7660", "id": "reaction_390184", "reactome": "R-DME-390184", "name": "YKI binds to SD and activates transcription", "reversible": "false", "notes": "The transcriptional factor Yorkie (YKI) forms a transcriptional activation complex for its target genes with Scalloped (SD).", "reactants": [ "species_390187", "species_390143" ], "products": [ "species_390092" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P30052", "sd" ] }, "reaction_451819": { "compartment": "compartment_7660", "id": "reaction_451819", "reactome": "R-DME-451819", "name": "YKI binds to HTH and TSH and activates transcription", "reversible": "false", "notes": "Yorkie (YKI) binds to the DNA-binding transcription factor, Homothorax (HTH). HTH in conjunction with the DNA-binding transcription factor, Teashirt (TSH) regulate the YKI target gene for the microRNA bantam (ban). HTH and YKI are both bound to the same region of the bantam locus in eye discs. This suggests that YKI, HTH, and TSH form a DNA-binding complex which activates transcription for the bantam target gene.", "reactants": [ "species_451881", "species_451832", "species_390143" ], "products": [ "species_451887" ], "modifiers": [], "additional_components": [ "Q45VV3", "yki", "P22265", "TSH", "O46339", "HTH" ] }, "reaction_10436586": { "compartment": "compartment_5460", "id": "reaction_10436586", "reactome": "R-DME-163320", "name": "Association of mTERF with the termination sequence", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164569", "species_10436582" ], "products": [ "species_10436584" ], "modifiers": [], "additional_components": [ "FBgn0028530", "Q9V3F3", "FBgn0028530" ] }, "reaction_10432638": { "compartment": "compartment_7660", "id": "reaction_10432638", "reactome": "R-DME-75949", "name": "RNA Polymerase II Promoter Opening: First Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10432467" ], "products": [ "species_113550", "species_113582", "species_10432459" ], "modifiers": [ [ "species_10431174", "catalyst" ] ], "additional_components": [ "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10432479": { "compartment": "compartment_7660", "id": "reaction_10432479", "reactome": "R-DME-75869", "name": "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432427", "species_30595" ], "products": [ "species_10431322", "species_113541", "species_10432477" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10432430": { "compartment": "compartment_7660", "id": "reaction_10432430", "reactome": "R-DME-75850", "name": "Addition of the third nucleotide on the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431434", "species_30595" ], "products": [ "species_113541", "species_10432427" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10432494": { "compartment": "compartment_7660", "id": "reaction_10432494", "reactome": "R-DME-75873", "name": "Addition of Nucleotides 5 through 9 on the growing Transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10432477" ], "products": [ "species_10431317", "species_10431432", "species_113541", "species_10431420", "species_10432492" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10434104": { "compartment": "compartment_7660", "id": "reaction_10434104", "reactome": "R-DME-111264", "name": "Addition of nucleotides between position +11 and +30", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433060", "species_30595" ], "products": [ "species_10433097", "species_113541" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10497528": { "compartment": "compartment_7660", "id": "reaction_10497528", "reactome": "R-DME-9613494", "name": "Unwinding of DNA for the Nascent Transcript: Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10432427" ], "products": [ "species_164121", "species_113541", "species_10432427" ], "modifiers": [ [ "species_10431174", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10433062": { "compartment": "compartment_7660", "id": "reaction_10433062", "reactome": "R-DME-76576", "name": "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10432492" ], "products": [ "species_10433060", "species_113541" ], "modifiers": [ [ "species_10429256", "catalyst" ] ], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10497530": { "compartment": "compartment_7660", "id": "reaction_10497530", "reactome": "R-DME-9613497", "name": "Unwinding DNA for the nascent transcript", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431434", "species_30595" ], "products": [ "species_10431434", "species_113541" ], "modifiers": [ [ "species_10431174", "catalyst" ] ], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "species_110577", "species_113592", "species_29494", "species_29438", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929" ] }, "reaction_10434782": { "compartment": "compartment_7660", "id": "reaction_10434782", "reactome": "R-DME-112385", "name": "Addition of nucleotides leads to transcript elongation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10434765" ], "products": [ "species_10431174", "species_10434780" ], "modifiers": [], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P20232", "FBgn0010422", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q7JRJ1", "FBgn0033166", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q9W147", "FBgn0035026", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "A8JV07", "FBgn0030738", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434796": { "compartment": "compartment_7660", "id": "reaction_10434796", "reactome": "R-DME-112396", "name": "Separation of elongating transcript from template", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434792" ], "products": [ "species_10434794" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434818": { "compartment": "compartment_7660", "id": "reaction_10434818", "reactome": "R-DME-113412", "name": "Pol II elongation complex moves on the template as transcript elongates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30595", "species_10434780" ], "products": [ "species_10434792", "species_30595" ], "modifiers": [], "additional_components": [ "species_110577", "species_113592", "species_29494", "species_29438", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "species_110577", "species_113592", "species_29494", "species_29438" ] }, "reaction_10492379": { "compartment": "compartment_161320", "id": "reaction_10492379", "reactome": "R-DME-8938108", "name": "SERPINB13 binds cathepsin L", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492375", "species_10492373" ], "products": [ "species_10492377" ], "modifiers": [], "additional_components": [ "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229" ] }, "reaction_10492383": { "compartment": "compartment_161320", "id": "reaction_10492383", "reactome": "R-DME-8938121", "name": "SERPINB13 binds CTSK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492373", "species_10465003" ], "products": [ "species_10492381" ], "modifiers": [], "additional_components": [ "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q95029", "FBgn0013770", "Q7K0S6", "FBgn0033874", "A1ZAU4", "FBgn0034229", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293" ] }, "reaction_10492387": { "compartment": "compartment_7660", "id": "reaction_10492387", "reactome": "R-DME-8938217", "name": "RUNX1 binds the SWI/SNF complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467716", "species_10489794" ], "products": [ "species_10492385" ], "modifiers": [], "additional_components": [ "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715" ] }, "reaction_10491720": { "compartment": "compartment_7660", "id": "reaction_10491720", "reactome": "R-DME-8878050", "name": "HIPK2 phosphorylates RUNX1 and EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10491687" ], "products": [ "species_113582", "species_10491717" ], "modifiers": [ [ "species_10469635", "catalyst" ] ], "additional_components": [ "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9MS40", "FBgn0261617", "FBgn0035142" ] }, "reaction_10491722": { "compartment": "compartment_7660", "id": "reaction_10491722", "reactome": "R-DME-8878054", "name": "HIPK2 phosphorylates RUNX1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10489794" ], "products": [ "species_113582", "species_10491715" ], "modifiers": [ [ "species_10469635", "catalyst" ] ], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0035142" ] }, "reaction_10492299": { "compartment": "compartment_7660", "id": "reaction_10492299", "reactome": "R-DME-8937989", "name": "RUNX1 binds PRC1 complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492295", "species_10489794" ], "products": [ "species_10492297" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10491724": { "compartment": "compartment_7660", "id": "reaction_10491724", "reactome": "R-DME-8878056", "name": "RUNX1:CBFB binds EP300", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489794", "species_10458126" ], "products": [ "species_10491687" ], "modifiers": [], "additional_components": [ "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "FBgn0261617", "M9MS40", "FBgn0261617", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753" ] }, "reaction_10492446": { "compartment": "compartment_7660", "id": "reaction_10492446", "reactome": "R-DME-8938913", "name": "RUNX1 binds ELF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492442", "species_10489794" ], "products": [ "species_10492444" ], "modifiers": [], "additional_components": [ "FBgn0000567", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "P11536", "FBgn0000567" ] }, "reaction_10492480": { "compartment": "compartment_7660", "id": "reaction_10492480", "reactome": "R-DME-8938951", "name": "RUNX1 binds PAX5 (BSAP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492476", "species_10489794" ], "products": [ "species_10492478" ], "modifiers": [], "additional_components": [ "O16117", "FBgn0005561", "O18381", "FBgn0005558", "P23758", "FBgn0003130", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "O16117", "FBgn0005561", "O18381", "FBgn0005558", "P23758", "FBgn0003130" ] }, "reaction_10492459": { "compartment": "compartment_7660", "id": "reaction_10492459", "reactome": "R-DME-8938930", "name": "RUNX1 binds ELF2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492455", "species_10489794" ], "products": [ "species_10492457" ], "modifiers": [], "additional_components": [ "P11536", "FBgn0000567", "Q01842", "FBgn0000097", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981", "P22814", "FBgn0003300", "Q9VRA9", "FBgn0259162", "Q9W349", "FBgn0002576", "Q24040", "FBgn0013753", "P11536", "FBgn0000567", "Q01842", "FBgn0000097" ] }, "reaction_10494980": { "compartment": "compartment_7660", "id": "reaction_10494980", "reactome": "R-DME-8953115", "name": "E2F6:TFDP1 binds to MGA:MAX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494970", "species_10494976" ], "products": [ "species_10494978" ], "modifiers": [], "additional_components": [ "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763" ] }, "reaction_10495062": { "compartment": "compartment_7660", "id": "reaction_10495062", "reactome": "R-DME-8954082", "name": "E2F6 binds the PRC1 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495049", "species_10495058" ], "products": [ "species_10495060" ], "modifiers": [], "additional_components": [ "Q9W215", "FBgn0034763", "Q9VB08", "FBgn0003330", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "Q9VKL0", "FBgn0032330", "P39769", "FBgn0004861", "Q9W523", "FBgn0004860", "Q9W215", "FBgn0034763", "Q9VB08", "FBgn0003330", "P35820", "FBgn0005624", "P25172", "FBgn0265623", "Q9VKL0", "FBgn0032330", "P39769", "FBgn0004861", "Q9W523", "FBgn0004860" ] }, "reaction_10495047": { "compartment": "compartment_7660", "id": "reaction_10495047", "reactome": "R-DME-8954056", "name": "E2F6 binds TFDP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494968", "species_10457961" ], "products": [ "species_10495045" ], "modifiers": [], "additional_components": [ "FBgn0011763", "Q24318", "FBgn0011763", "Q27368", "phospho-E2f1" ] }, "reaction_10494984": { "compartment": "compartment_7660", "id": "reaction_10494984", "reactome": "R-DME-8953418", "name": "EHMT1:EHMT2 complex binds E2F6.com-1 core", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468978", "species_10494978" ], "products": [ "species_10494982" ], "modifiers": [], "additional_components": [ "M9PGH7", "FBgn0040372", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "M9PGH7", "FBgn0040372" ] }, "reaction_10495850": { "compartment": "compartment_7660", "id": "reaction_10495850", "reactome": "R-DME-9007539", "name": "CHEK1 phosphorylates E2F6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10494968" ], "products": [ "species_113582", "species_10495848" ], "modifiers": [ [ "species_10427785", "catalyst" ] ], "additional_components": [ "FBgn0261278" ] }, "reaction_10494972": { "compartment": "compartment_7660", "id": "reaction_10494972", "reactome": "R-DME-8953111", "name": "E2F6 binds TFDP1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457959", "species_10494968" ], "products": [ "species_10494970" ], "modifiers": [], "additional_components": [ "FBgn0011763", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763" ] }, "reaction_10495839": { "compartment": "compartment_7660", "id": "reaction_10495839", "reactome": "R-DME-9007283", "name": "CBX3 and PRC1.6 associate with E2F6.com-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495835", "species_10494982", "species_10495829" ], "products": [ "species_10495837" ], "modifiers": [], "additional_components": [ "Q9VK33", "FBgn0032475", "Q9VB08", "FBgn0003330", "Q9W215", "FBgn0034763", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "M9PGH7", "FBgn0040372", "FBgn0039019", "Q9VCU6", "FBgn0039019", "P91664", "FBgn0017578", "Q9W3F4", "FBgn0021767", "Q27368", "phospho-E2f1", "Q24318", "FBgn0011763", "M9PGH7", "FBgn0040372", "Q9VK33", "FBgn0032475", "Q9VB08", "FBgn0003330", "Q9W215", "FBgn0034763" ] }, "reaction_10492290": { "compartment": "compartment_70101", "id": "reaction_10492290", "reactome": "R-DME-8937807", "name": "SRC phosphorylates RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492282", "species_113592" ], "products": [ "species_10492287", "species_29370", "species_10444503" ], "modifiers": [ [ "species_10492282", "catalyst" ] ], "additional_components": [ "P00528", "FBgn0262733", "M9PI08", "FBgn0083981", "FBgn0083981", "FBgn0262733", "P00528", "FBgn0262733", "M9PI08", "FBgn0083981" ] }, "reaction_10492292": { "compartment": "compartment_70101", "id": "reaction_10492292", "reactome": "R-DME-8937814", "name": "RUNX3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492280" ], "products": [ "species_10489801" ], "modifiers": [ [ "species_10437860", "catalyst" ], [ "species_10444503", "inhibitor" ] ], "additional_components": [ "FBgn0083981", "FBgn0083981", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q9V4E6", "FBgn0039914", "FBgn0262733" ] }, "reaction_10494821": { "compartment": "compartment_7660", "id": "reaction_10494821", "reactome": "R-DME-8952419", "name": "SMURFs ubiquitinate RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427430", "species_10489801" ], "products": [ "species_10494816" ], "modifiers": [ [ "species_10494818", "catalyst" ], [ "species_10458126", "inhibitor" ] ], "additional_components": [ "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "FBgn0083981", "FBgn0083981", "FBgn0029006", "FBgn0261617" ] }, "reaction_10492284": { "compartment": "compartment_70101", "id": "reaction_10492284", "reactome": "R-DME-8937792", "name": "RUNX3 binds SRC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10492280", "species_10444503" ], "products": [ "species_10492282" ], "modifiers": [], "additional_components": [ "FBgn0083981", "FBgn0262733", "P00528", "FBgn0262733", "M9PI08", "FBgn0083981" ] }, "reaction_10494812": { "compartment": "compartment_7660", "id": "reaction_10494812", "reactome": "R-DME-8952399", "name": "Polyubiquitinated RUNX3 translocates to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494808" ], "products": [ "species_10494810" ], "modifiers": [], "additional_components": [ "FBgn0083981", "FBgn0083981" ] }, "reaction_10489805": { "compartment": "compartment_7660", "id": "reaction_10489805", "reactome": "R-DME-8865454", "name": "CBFB binds RUNX3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489801", "species_10489782" ], "products": [ "species_10489803" ], "modifiers": [], "additional_components": [ "FBgn0083981", "FBgn0013753", "Q24040", "FBgn0013753", "M9PI08", "FBgn0083981" ] }, "reaction_10494814": { "compartment": "compartment_70101", "id": "reaction_10494814", "reactome": "R-DME-8952408", "name": "Polyubiquitinated RUNX3 is degraded by the proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494810" ], "products": [ "species_10426987" ], "modifiers": [ [ "species_10438205", "catalyst" ] ], "additional_components": [ "FBgn0083981", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P12881", "Prosalpha6", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7KLV9", "Rpn6", "Q9V3P6", "Rpn2", "Q9W414", "FBgn0028685", "O18413", "Rpt6", "Q9V405", "Rpt3", "Q9V3V6", "Rpt5", "Q7KMQ0", "Rpt1", "P48601", "Rpt2", "A0AQH0", "FBgn0010590", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "Q7K148", "FBgn0029134", "Q9VUJ1", "Prosbeta2", "Q9VNA5", "Prosbeta7", "Q9XYN7", "Prosbeta3", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P3", "FBgn0029133", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9VFS8", "FBgn0038166", "Q9V436", "Rpn12", "P40304", "Prosbeta6", "P26270", "Rpn8", "P22769", "Prosalpha4", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "P55035", "Rpn10", "P18053", "FBgn0261394", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q7KMP8", "Rpn9" ] }, "reaction_10493669": { "compartment": "compartment_7660", "id": "reaction_10493669", "reactome": "R-DME-8951428", "name": "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468258", "species_10489801" ], "products": [ "species_10493667" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0083981", "M9PI08", "FBgn0083981", "P18824", "arm", "Q8IMA8", "FBgn0085432" ] }, "reaction_10445384": { "compartment": "compartment_7660", "id": "reaction_10445384", "reactome": "R-DME-376419", "name": "Formation of NR-MED1 Coactivator Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445380", "species_10445375" ], "products": [ "species_10445382" ], "modifiers": [], "additional_components": [ "FBgn0037109", "P13054", "FBgn0001323", "P16376", "FBgn0003651", "Q05192", "FBgn0261239", "P33244", "FBgn0001078", "Q24142", "FBgn0015239", "P49866", "FBgn0004914", "P49869", "FBgn0014859", "Q24143", "FBgn0015240", "P34021", "FBgn0000546", "A1ZA01", "FBgn0034012", "P18102", "FBgn0003720", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P31396", "FBgn0000448", "Q9Y0Y6", "FBgn0027497", "P45447", "FBgn0004865", "E1JHX0", "FBgn0260756", "Q8WS79", "FBgn0035849", "P13054", "FBgn0001323", "P16376", "FBgn0003651", "Q05192", "FBgn0261239", "P33244", "FBgn0001078", "Q24142", "FBgn0015239", "P49866", "FBgn0004914", "P49869", "FBgn0014859", "Q24143", "FBgn0015240", "P34021", "FBgn0000546", "A1ZA01", "FBgn0034012", "P18102", "FBgn0003720", "P20153", "FBgn0003964", "P13055", "FBgn0000568", "P31396", "FBgn0000448", "Q9Y0Y6", "FBgn0027497", "P45447", "FBgn0004865", "E1JHX0", "FBgn0260756", "Q8WS79", "FBgn0035849", "Q9VP05", "FBgn0037109" ] }, "reaction_10488872": { "compartment": "compartment_7660", "id": "reaction_10488872", "reactome": "R-DME-8853965", "name": "VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10488868", "species_10488864" ], "products": [ "species_10441673", "species_10488870" ], "modifiers": [], "additional_components": [ "P18824", "arm", "Q8IMA8", "FBgn0085432", "FBgn0000529", "Q04787", "FBgn0000529", "Q8IMA8", "FBgn0085432" ] }, "reaction_10490422": { "compartment": "compartment_7660", "id": "reaction_10490422", "reactome": "R-DME-8869580", "name": "DEK binds TFAP2A homodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489710", "species_10490418" ], "products": [ "species_10490420" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0026533", "Q8T0D3", "FBgn0026533", "M9PIH9", "FBgn0261953" ] }, "reaction_10489712": { "compartment": "compartment_7660", "id": "reaction_10489712", "reactome": "R-DME-8864278", "name": "AP-2 (TFAP2) transcription factors form homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489702" ], "products": [ "species_10489710" ], "modifiers": [], "additional_components": [ "FBgn0261953", "M9PIH9", "FBgn0261953" ] }, "reaction_10489731": { "compartment": "compartment_70101", "id": "reaction_10489731", "reactome": "R-DME-8864577", "name": "TFAP2C translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489725" ], "products": [ "species_10467863" ], "modifiers": [ [ "species_10489727", "inhibitor" ] ], "additional_components": [ "FBgn0261953", "FBgn0261953", "Q9VLU5", "FBgn0031972", "M9PIH9", "FBgn0261953" ] }, "reaction_10489743": { "compartment": "compartment_7660", "id": "reaction_10489743", "reactome": "R-DME-8864595", "name": "TFAP2B homodimer binds YEATS4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489739", "species_10489737" ], "products": [ "species_10489741" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0031873", "Q9VM63", "FBgn0031873", "M9PIH9", "FBgn0261953" ] }, "reaction_10489729": { "compartment": "compartment_70101", "id": "reaction_10489729", "reactome": "R-DME-8864569", "name": "WWOX binds TFAP2C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489725", "species_10458536" ], "products": [ "species_10489727" ], "modifiers": [], "additional_components": [ "FBgn0261953", "FBgn0031972", "Q9VLU5", "FBgn0031972", "M9PIH9", "FBgn0261953" ] }, "reaction_10489721": { "compartment": "compartment_7660", "id": "reaction_10489721", "reactome": "R-DME-8864343", "name": "KCTD1 binds TFAP2 homo- and heterodimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489710", "species_10489717" ], "products": [ "species_10489719" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0034636", "D5SHR0", "FBgn0034636", "M9PIH9", "FBgn0261953" ] }, "reaction_10489769": { "compartment": "compartment_7660", "id": "reaction_10489769", "reactome": "R-DME-8865265", "name": "TFAP2C homodimer binds MYC and KDM5B", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467865", "species_10489765", "species_10489760" ], "products": [ "species_10489767" ], "modifiers": [], "additional_components": [ "M9PIH9", "FBgn0261953", "FBgn0031759", "FBgn0262656", "Q9W4S7", "FBgn0262656", "Q9VMJ7", "FBgn0031759", "M9PIH9", "FBgn0261953" ] }, "reaction_10497665": { "compartment": "compartment_7660", "id": "reaction_10497665", "reactome": "R-DME-9620515", "name": "KAT2B,EP300 acetylate FOXO3 under oxidative stress", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10441099" ], "products": [ "species_2485002", "species_10497660" ], "modifiers": [ [ "species_10497662", "catalyst" ], [ "species_3785707", "catalyst" ] ], "additional_components": [ "Q9VTZ1", "FBgn0020388" ] }, "reaction_10497764": { "compartment": "compartment_7660", "id": "reaction_10497764", "reactome": "R-DME-9626928", "name": "CREBBP binds FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441097", "species_10447242" ], "products": [ "species_10497762" ], "modifiers": [], "additional_components": [ "FBgn0261617", "M9MS40", "FBgn0261617", "Q95V55", "foxo" ] }, "reaction_10497672": { "compartment": "compartment_7660", "id": "reaction_10497672", "reactome": "R-DME-9620532", "name": "SIRT1,SIRT3 deacetylate FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497660", "species_427523" ], "products": [ "species_427497", "species_427498", "species_10441099" ], "modifiers": [ [ "species_10497669", "catalyst" ] ], "additional_components": [ "Q9I7I7", "FBgn0038788", "Q9VK34", "FBgn0024291" ] }, "reaction_10497573": { "compartment": "compartment_70101", "id": "reaction_10497573", "reactome": "R-DME-9614423", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497569", "species_10443103" ], "products": [ "species_10497571" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "Q95V55", "foxo", "P29310", "14-3-3zeta" ] }, "reaction_10497579": { "compartment": "compartment_70101", "id": "reaction_10497579", "reactome": "R-DME-9614562", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497563", "species_10497575" ], "products": [ "species_10497577" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "Q95V55", "foxo" ] }, "reaction_10497567": { "compartment": "compartment_7660", "id": "reaction_10497567", "reactome": "R-DME-9614414", "name": "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441108" ], "products": [ "species_10443103" ], "modifiers": [], "additional_components": [] }, "reaction_10497583": { "compartment": "compartment_70101", "id": "reaction_10497583", "reactome": "R-DME-9614564", "name": "14-3-3 proteins bind AKT-phosphorylated FOXO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497565", "species_10432006" ], "products": [ "species_10497581" ], "modifiers": [], "additional_components": [ "P29310", "14-3-3zeta", "P29310", "14-3-3zeta", "Q95V55", "foxo" ] }, "reaction_10497637": { "compartment": "compartment_7660", "id": "reaction_10497637", "reactome": "R-DME-9618021", "name": "FOXG1 binds FOXO:SMAD complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497628", "species_10497633" ], "products": [ "species_10497635" ], "modifiers": [], "additional_components": [ "Q95V55", "foxo", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "FBgn0004567", "P32031", "FBgn0004567", "Q95V55", "foxo", "O96660", "FBgn0025800", "O62609", "FBgn0011655" ] }, "reaction_10497626": { "compartment": "compartment_7660", "id": "reaction_10497626", "reactome": "R-DME-9617996", "name": "FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441097", "species_10437946" ], "products": [ "species_10497624" ], "modifiers": [], "additional_components": [ "O96660", "FBgn0025800", "O62609", "FBgn0011655", "O96660", "FBgn0025800", "O62609", "FBgn0011655", "Q95V55", "foxo" ] }, "reaction_10434814": { "compartment": "compartment_7660", "id": "reaction_10434814", "reactome": "R-DME-113409", "name": "Abortive termination of early transcription elongation by DSIF:NELF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434775" ], "products": [ "species_10434775" ], "modifiers": [], "additional_components": [ "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q9W147", "FBgn0035026", "Q6IGE3", "FBgn0262954", "Q9VJE4", "FBgn0032634", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q9VNZ3", "FBgn0037121", "P04052", "FBgn0003277", "O97183", "FBgn0026373", "Q9VFB5", "FBgn0051155", "Q9VC49", "FBgn0039218", "Q9VEA5", "FBgn0263757", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943" ] }, "reaction_10434808": { "compartment": "compartment_7660", "id": "reaction_10434808", "reactome": "R-DME-112437", "name": "Formation of NELF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434644", "species_10434629", "species_10434634", "species_10434639" ], "products": [ "species_10434646" ], "modifiers": [], "additional_components": [ "FBgn0017430", "FBgn0038872", "FBgn0027553", "FBgn0010416", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430" ] }, "reaction_10434806": { "compartment": "compartment_7660", "id": "reaction_10434806", "reactome": "R-DME-112436", "name": "Formation of Elongin complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434710", "species_10434715" ], "products": [ "species_10434721" ], "modifiers": [], "additional_components": [ "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "FBgn0039066", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212" ] }, "reaction_10432469": { "compartment": "compartment_7660", "id": "reaction_10432469", "reactome": "R-DME-75862", "name": "Fall Back to Closed Pre-initiation Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432459" ], "products": [ "species_10432467" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10434804": { "compartment": "compartment_7660", "id": "reaction_10434804", "reactome": "R-DME-112435", "name": "Formation of Elongin BC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434708", "species_10434703" ], "products": [ "species_10434710" ], "modifiers": [], "additional_components": [ "FBgn0023212", "FBgn0266711", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212" ] }, "reaction_10434802": { "compartment": "compartment_7660", "id": "reaction_10434802", "reactome": "R-DME-112434", "name": "Formation of DSIF complex ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433111", "species_10434651" ], "products": [ "species_10434653" ], "modifiers": [], "additional_components": [ "FBgn0040273", "FBgn0028683", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273" ] }, "reaction_10434800": { "compartment": "compartment_7660", "id": "reaction_10434800", "reactome": "R-DME-112430", "name": "Formation of P-TEFb complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434608", "species_10434622" ], "products": [ "species_10434624" ], "modifiers": [], "additional_components": [ "FBgn0019949", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434798": { "compartment": "compartment_7660", "id": "reaction_10434798", "reactome": "R-DME-112429", "name": "Formation of FACT complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434691", "species_10434696" ], "products": [ "species_10434698" ], "modifiers": [], "additional_components": [ "FBgn0010278", "FBgn0002183", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278" ] }, "reaction_10431436": { "compartment": "compartment_7660", "id": "reaction_10431436", "reactome": "R-DME-73946", "name": "Abortive initiation after formation of the first phosphodiester bond", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431434" ], "products": [ "species_10431317", "species_10431174", "species_10431432", "species_10429256", "species_10431322", "species_109877", "species_10431420" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10432457": { "compartment": "compartment_7660", "id": "reaction_10432457", "reactome": "R-DME-75856", "name": "Abortive Initiation Before Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432455" ], "products": [ "species_10431317", "species_10431174", "species_10431432", "species_10429256", "species_10431322", "species_110068", "species_10431420" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10434822": { "compartment": "compartment_7660", "id": "reaction_10434822", "reactome": "R-DME-113414", "name": "7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434780" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434790": { "compartment": "compartment_7660", "id": "reaction_10434790", "reactome": "R-DME-112395", "name": "Abortive termination of elongation after arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434788" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10432613": { "compartment": "compartment_7660", "id": "reaction_10432613", "reactome": "R-DME-75891", "name": "Abortive Initiation After Second Transition", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432611" ], "products": [ "species_10431174", "species_75897", "species_10431432", "species_10429256" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10434820": { "compartment": "compartment_7660", "id": "reaction_10434820", "reactome": "R-DME-113413", "name": "TFIIS-mediated recovery of elongation from arrest", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434780" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434786": { "compartment": "compartment_7660", "id": "reaction_10434786", "reactome": "R-DME-112392", "name": "Resumption of elongation after recovery from pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434784" ], "products": [ "species_10434780" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10434816": { "compartment": "compartment_7660", "id": "reaction_10434816", "reactome": "R-DME-113411", "name": "2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434780" ], "products": [ "species_10434784" ], "modifiers": [], "additional_components": [ "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "species_110577", "species_113592", "species_29494", "species_29438", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "P20232", "FBgn0010422", "Q9TVQ5", "FBgn0028683", "Q9V460", "FBgn0040273", "Q24134", "FBgn0010416", "Q9Y113", "FBgn0027553", "Q86NP2", "FBgn0038872", "P92204", "FBgn0017430", "Q9VW51", "FBgn0014037", "Q7JRJ1", "FBgn0033166", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9W420", "FBgn0028982", "Q8IRG6", "FBgn0002183", "Q05344", "FBgn0010278", "Q9VQI9", "FBgn0041111", "A8JV07", "FBgn0030738", "Q9W147", "FBgn0035026", "Q9VCP0", "FBgn0039066", "Q7JWD6", "FBgn0266711", "O44226", "FBgn0023212", "Q9XZ19", "FBgn0027524", "Q7K0X3", "FBgn0035205", "Q9W261", "FBgn0034722", "Q9VHI1", "FBgn0037657", "Q9VN55", "FBgn0010750", "Q94546", "FBgn0019637", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10433419": { "compartment": "compartment_7660", "id": "reaction_10433419", "reactome": "R-DME-109639", "name": "Formation of the closed pre-initiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432082", "species_10431174" ], "products": [ "species_10432467" ], "modifiers": [], "additional_components": [ "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VPX4", "FBgn0031309", "Q7KPG8", "FBgn0024956", "O76513", "FBgn0022936", "Q24216", "FBgn0263237", "B7Z018", "FBgn0265968", "Q9VNP8", "FBgn0037202", "Q7KVP9", "FBgn0261850", "Q9VUR1", "FBgn0261109", "Q02870", "FBgn0001179", "Q960E8", "FBgn0033929", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10433417": { "compartment": "compartment_7660", "id": "reaction_10433417", "reactome": "R-DME-109638", "name": "Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429256", "species_10432078" ], "products": [ "species_10432080" ], "modifiers": [], "additional_components": [ "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10433415": { "compartment": "compartment_7660", "id": "reaction_10433415", "reactome": "R-DME-109637", "name": "Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431317", "species_10431322", "species_10432076" ], "products": [ "species_10432078" ], "modifiers": [], "additional_components": [ "P52654", "FBgn0011289", "P52656", "FBgn0013347", "FBgn0004915", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347" ] }, "reaction_10433413": { "compartment": "compartment_7660", "id": "reaction_10433413", "reactome": "R-DME-109636", "name": "Recognition and Binding of Core Promoter Elements by TFIID", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109627", "species_10431420" ], "products": [ "species_10432076" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262" ] }, "reaction_10432084": { "compartment": "compartment_7660", "id": "reaction_10432084", "reactome": "R-DME-75095", "name": "Binding of TFIIE to the growing preinitiation complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432080", "species_10431432" ], "products": [ "species_10432082" ], "modifiers": [], "additional_components": [ "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "Q24325", "FBgn0011836", "Q9VGJ3", "FBgn0037939", "Q27294", "FBgn0285954", "P47825", "FBgn0010280", "Q9VJP5", "FBgn0041103", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q9VHY5", "FBgn0024909", "Q9XZT7", "FBgn0026324", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "P49906", "FBgn0011291", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "P51123", "FBgn0010355", "P49905", "FBgn0011290", "Q9V4D4", "FBgn0026262", "P29052", "FBgn0004915", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155" ] }, "reaction_10486881": { "compartment": "compartment_7660", "id": "reaction_10486881", "reactome": "R-DME-6810233", "name": "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10486869" ], "products": [ "species_113582", "species_10486878" ], "modifiers": [ [ "species_10486869", "catalyst" ] ], "additional_components": [ "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24216", "FBgn0263237", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q24216", "FBgn0263237", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10486883": { "compartment": "compartment_7660", "id": "reaction_10486883", "reactome": "R-DME-6810238", "name": "RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10487478" ], "products": [ "species_10487486", "species_10487480" ], "modifiers": [ [ "species_10487478", "catalyst" ], [ "species_10430034", "catalyst" ], [ "species_10487492", "catalyst" ] ], "additional_components": [ "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "X2JAA3", "FBgn0032688", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", 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"FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", 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"FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "FBgn0264962", "FBgn0031054" ] }, "reaction_10487465": { "compartment": "compartment_7660", "id": "reaction_10487465", "reactome": "R-DME-6814549", "name": "Pre-snRNA transcript initiation, Integrator binding, LEC binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29470", "species_29358", "species_113562", "species_113571", "species_10487441", "species_10487456", "species_10487360" ], "products": [ "species_10487462" ], "modifiers": [ [ "species_10487360", "catalyst" ], [ "species_10434653", "catalyst" ] ], "additional_components": [ "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", 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demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. 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"FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "X2JAA3", "FBgn0032688", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10487630": { "compartment": "compartment_7660", "id": "reaction_10487630", "reactome": "R-DME-6814885", "name": "CBCAP complex binds 7-methylguanosine cap of snRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429169", "species_10487498", "species_10440022", "species_10429515" ], "products": [ "species_10487478" ], "modifiers": [], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "X2JAA3", "FBgn0032688", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P04052", "FBgn0003277", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "species_430042", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949", "FBgn0033380", "FBgn0033062", "Q9VXP4", "FBgn0025809", "P22293", "FBgn0003575", "Q9VW51", "FBgn0014037", "Q95TS5", "FBgn0036570", "Q7PLS8", "FBgn0262117", "Q9VEX5", "FBgn0020407", "Q9VPY0", "FBgn0031314", "Q9W3E1", "FBgn0026679", "Q9VAH9", "FBgn0039691", "Q9VFS6", "FBgn0038168", "Q9W1C5", "FBgn0034964", "Q9VM17", "FBgn0031909", "Q9W485", "FBgn0261383", "Q9VZM7", "FBgn0035462", "Q9VT41", "FBgn0036038", "Q9VBB3", "FBgn0039459", "A1ZAK1", "FBgn0025830", "Q9VX31", "FBgn0030858", "Q9W039", "FBgn0035318", "X2JAA3", "FBgn0032688", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P04052", "FBgn0003277", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "species_430042", "Q9V9K7", "FBgn0033062", "A1Z7P3", "FBgn0033380", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VF25", "FBgn0038371", "Q9VHX0", "FBgn0037540", "Q2MGN0", "FBgn0034946", "Q24266", "FBgn0000233", "M9PJG1", "FBgn0020378", "Q9VPQ5", "FBgn0043364", "P31368", "FBgn0085424", "Q9VK71", "FBgn0004394", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "P29052", "FBgn0004915", "O96881", "FBgn0015829", "O96880", "FBgn0015828", "Q27896", "FBgn0010287", "P20227", "FBgn0003687", "Q9VQE8", "FBgn0031446", "Q9VQE6", "FBgn0031444", "Q9VIP1", "FBgn0032847", "P49846", "FBgn0010356", "Q9VT91", "FBgn0011569", "Q9VCN9", "FBgn0039067", "Q9VWY6", "FBgn0022724", "P49906", "FBgn0011291", "Q27272", "FBgn0000617", "P49847", "FBgn0010417", "P52654", "FBgn0011289", "P52656", "FBgn0013347", "Q24216", "FBgn0263237", "O96433", "FBgn0025455", "Q961D1", "FBgn0025674", "O17432", "FBgn0019949" ] }, "reaction_10471026": { "compartment": "compartment_7660", "id": "reaction_10471026", "reactome": "R-DME-5221061", "name": "TDG excises 5-carboxylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5220996", "species_10433855" ], "products": [ "species_10433873", "species_5221064" ], "modifiers": [ [ "species_10433855", "catalyst" ] ], "additional_components": [ "FBgn0026869", "Q9V4D8", "FBgn0026869", "FBgn0026869" ] }, "reaction_10471024": { "compartment": "compartment_7660", "id": "reaction_10471024", "reactome": "R-DME-5220959", "name": "TDG excises 5-formylcytosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5221062", "species_10433855" ], "products": [ "species_10433873", "species_5221065" ], "modifiers": [ [ "species_10433855", "catalyst" ] ], "additional_components": [ "FBgn0026869", "Q9V4D8", "FBgn0026869", "FBgn0026869" ] }, "reaction_209227": { "compartment": "compartment_70101", "id": "reaction_209227", "reactome": "R-DME-209227", "name": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the PGN:PGRP-LC oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The Drosophila orthologue of IKKB (IRD5) phosphorylates Relish (REL).", "reactants": [ "species_113592", "species_354323" ], "products": [ "species_29370", "species_354322" ], "modifiers": [ [ "species_206633", "catalyst" ] ], "additional_components": [ "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "species_214401", "CHEBI:28881", "species_1678743", "Q9GNK5-2", "PGRP-LCx", "Q9GNK5-1", "PGRP-LCa", "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta" ] }, "reaction_214398": { "compartment": "compartment_70101", "id": "reaction_214398", "reactome": "R-DME-214398", "name": "Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'", "reversible": "false", "notes": "The Drosophila orthologue of IKKB (IRD5) phosphorylates Relish (REL).", "reactants": [ "species_113592", "species_214406" ], "products": [ "species_29370", "species_214409" ], "modifiers": [ [ "species_206633", "catalyst" ] ], "additional_components": [ "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q94527", "Rel", "Q8IRY7", "phospho-Dredd", "Q9V3B4", "BG4", "species_214401", "Q9VXN9", "PGRP-LE", "Q7K4Z4", "IMD", "Q8IRY7", "phospho-Dredd", "Q94527", "Rel", "Q9V3B4", "BG4", "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta" ] }, "reaction_209200": { "compartment": "compartment_70101", "id": "reaction_209200", "reactome": "R-DME-209200", "name": "HEP is phosphorylated and activated by Phospho TAK1:TAB2 kinase complex", "reversible": "false", "notes": "MAP kinase kinase orthologue, the dual specificity kinase Hemipterous (HEP), is phosphorylated and activated in its activation loop at residues Ser348 and Thr352 by the MAP kinase kinase kinase orthologue, phosphorylated TAK1.", "reactants": [ "species_113592", "species_206293" ], "products": [ "species_29370", "species_205776" ], "modifiers": [ [ "species_206922", "catalyst" ] ], "additional_components": [ "P35128", "ben", "Q24307", "Diap2", "Q9V3Q6", "TAK1", "Q4TZQ4", "TAB2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209188": { "compartment": "compartment_70101", "id": "reaction_209188", "reactome": "R-DME-209188", "name": "TAK1-binding protein TAB2 binds to TAK1 kinase", "reversible": "false", "notes": "Areas in the C-terminal part of TAB2 (not the Zinc-finger domain) bind to TAK1 Ser/Thr kinase.", "reactants": [ "species_205754", "species_206059" ], "products": [ "species_206731" ], "modifiers": [], "additional_components": [ "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1" ] }, "reaction_209179": { "compartment": "compartment_70101", "id": "reaction_209179", "reactome": "R-DME-209179", "name": "IAP2:BEN:UEV1A E3 ligase complex auto-ubiquitinates", "reversible": "false", "notes": "The Apoptosis 2 Inhibitor (IAP2):Bendless (BEN):UEV1A E3 ubiquitin ligase complex autoubiquitinates, forming Lys63-linked ubiquitin chains.", "reactants": [ "species_206204", "species_207030" ], "products": [ "species_206608" ], "modifiers": [ [ "species_205735", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q9VRL1", "Uev1A", "P35128", "ben", "Q24307", "Diap2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209289": { "compartment": "compartment_70101", "id": "reaction_209289", "reactome": "R-DME-209289", "name": "TAB2 binds to ubiquitinated IAP2:BEN:UEV1A E3 ligase complex and activates TAK1 kinase", "reversible": "false", "notes": "TAB2 in complex with TAK1 kinase binds to the ubiquitin chains emanating from the Apoptosis 2 Inhibitor (IAP2):Bendless (BEN):UEV1A E3 ligase complex. The formation of an E3 ligase:TAB2:TAK1 complex may cause conformational changes to the catalytic domain of TAK1 thus inducing its kinase activity.", "reactants": [ "species_206731", "species_206608" ], "products": [ "species_206764" ], "modifiers": [], "additional_components": [ "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "P35128", "ben", "Q24307", "Diap2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209320": { "compartment": "compartment_70101", "id": "reaction_209320", "reactome": "R-DME-209320", "name": "Activated TAK1 kinase is autophosphorylated", "reversible": "false", "notes": "TAK1 kinase is phosphorylated at Thr171 by another activated TAK1 kinase in an intermolecular autophosphorylation.", "reactants": [ "species_206764", "species_113592" ], "products": [ "species_29370", "species_206922" ], "modifiers": [ [ "species_206764", "catalyst" ] ], "additional_components": [ "P35128", "ben", "Q24307", "Diap2", "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q9V3Q6", "TAK1", "Q4TZQ4", "TAB2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "P35128", "ben", "Q24307", "Diap2", "Q4TZQ4", "TAB2", "Q9V3Q6", "TAK1", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_209240": { "compartment": "compartment_70101", "id": "reaction_209240", "reactome": "R-DME-209240", "name": "Activated phosphorylated TAK1 kinase phosphorylates and activates IRD5", "reversible": "false", "notes": "IRD5 is phosphorylated and activated by phosphorylated TAK1 kinase at residues Thr217 and Ser221 in the activation loop.", "reactants": [ "species_113592", "species_206628" ], "products": [ "species_29370", "species_206633" ], "modifiers": [ [ "species_206922", "catalyst" ] ], "additional_components": [ "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta", "Q9GYV5", "KEY", "Q9VEZ5", "phospho-IKKbeta", "P35128", "ben", "Q24307", "Diap2", "Q9V3Q6", "TAK1", "Q4TZQ4", "TAB2", "Q9VRL1", "Uev1A", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12" ] }, "reaction_354273": { "compartment": "compartment_7660", "id": "reaction_354273", "reactome": "R-DME-354273", "name": "AP-1 transcription factor forms a complex with STAT92E and DSP1 which displaces REL-68 from its target gene", "reversible": "false", "notes": "When the JNK pathway is activated, the AP-1 transcription factor, a complex Jun-related antigen (JRA) and Kayak (KAY), forms a complex with the HMG protein, dorsal switch protein (DSP1) and STAT92E transcription factor (involved in the JAK/STAT pathway). This 'repressosome complex' and phosphorylated Relish (REL-68) are mutually exclusive in binding to this gene and so phosphorylated REL-68 is displaced from its target gene.", "reactants": [ "species_354268", "species_354285", "species_206244", "species_206724" ], "products": [ "species_354283", "species_354287", "species_354279" ], "modifiers": [], "additional_components": [ "O76216", "PCAF", "Q94527", "Rel", "P21525", "phospho-kay", "P18289", "phospho-Jra", "P21525", "phospho-kay", "Q24151", "Stat92E", "Q24537", "Dsp1", "P18289", "phospho-Jra" ] }, "reaction_354289": { "compartment": "compartment_7660", "id": "reaction_354289", "reactome": "R-DME-354289", "name": "AP-1:DSP1:STAT92E complex recruits RPD3 and represses transcription of the REL-68 target gene", "reversible": "false", "notes": "The 'repressosome complex' recruits the histone deacetylase RPD3 aka HDAC1 to the Relish target gene resulting in repression of its transcription. This is an example of the JNK pathway downregulating the Imd pathway.", "reactants": [ "species_354283", "species_354293" ], "products": [ "species_354291" ], "modifiers": [], "additional_components": [ "P21525", "phospho-kay", "Q24151", "Stat92E", "Q24537", "Dsp1", "P18289", "phospho-Jra", "Q94517", "HDAC1", "P21525", "phospho-kay", "Q24151", "Stat92E", "Q24537", "Dsp1", "P18289", "phospho-Jra" ] }, "reaction_209257": { "compartment": "compartment_7660", "id": "reaction_209257", "reactome": "R-DME-209257", "name": "Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription", "reversible": "false", "notes": "In the nucleus, phosphorylated Relish (REL-68) forms a complex with the histone acetyltransferase, PCAF, at its target gene and transcription is activated.", "reactants": [ "species_354287", "species_354279" ], "products": [ "species_354285" ], "modifiers": [], "additional_components": [ "O76216", "PCAF", "Q94527", "Rel" ] }, "reaction_209309": { "compartment": "compartment_13231", "id": "reaction_209309", "reactome": "R-DME-209309", "name": "Phosphorylated REL-68 transports from the cytosol to the nucleus", "reversible": "false", "notes": "The phosphorylated N-terminal cleaved domain of Relish (REL-68) translocates from the cytosol to the nucleus. The corresponding phosphorylated C-terminal cleaved domain (REL-49) remains in the cytoplasm.", "reactants": [ "species_354270" ], "products": [ "species_354287" ], "modifiers": [], "additional_components": [] }, "reaction_10472558": { "compartment": "compartment_70101", "id": "reaction_10472558", "reactome": "R-DME-5433074", "name": "ACY1:Zn2+ dimer hydrolyses mercapturic acids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490236", "species_29356" ], "products": [ "species_2022890", "species_5490231" ], "modifiers": [ [ "species_10472555", "catalyst" ] ], "additional_components": [ "CHEBI:78580", "CHEBI:78585", "CHEBI:78583", "CHEBI:78578", "species_1562550", "Q9I7K3", "FBgn0037818" ] }, "reaction_10472539": { "compartment": "compartment_876", "id": "reaction_10472539", "reactome": "R-DME-5433067", "name": "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490235" ], "products": [ "species_266029", "species_5490250" ], "modifiers": [ [ "species_10443761", "catalyst" ] ], "additional_components": [ "CHEBI:78579", "CHEBI:78584", "CHEBI:78578", "CHEBI:78583", "Q9VBG1", "FBgn0039420", "X2JCU8", "FBgn0266100", "Q9VPG0", "FBgn0036986", "Q9VJ94", "FBgn0261804", "species_1562550" ] }, "reaction_10472537": { "compartment": "compartment_70101", "id": "reaction_10472537", "reactome": "R-DME-5423653", "name": "MGST trimers transfer GS from GSH to AFXBO and AFNBO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5423723" ], "products": [ "species_5423730" ], "modifiers": [ [ "species_10438532", "catalyst" ] ], "additional_components": [ "CHEBI:30725", "CHEBI:78586", "CHEBI:78581", "CHEBI:78587", "Q8SY19", "FBgn0025814" ] }, "reaction_10472548": { "compartment": "compartment_984", "id": "reaction_10472548", "reactome": "R-DME-5433072", "name": "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5490253", "species_109276" ], "products": [ "species_210382", "species_5490235" ], "modifiers": [ [ "species_10472545", "catalyst" ] ], "additional_components": [ "CHEBI:78581", "CHEBI:78587", "CHEBI:78579", "CHEBI:78584", "Q7KUX2", "FBgn0030796", "M9NFP5", "FBgn0025837", "Q9VYR2", "FBgn0030361", "Q9VWT3", "FBgn0030932" ] }, "reaction_10486816": { "compartment": "compartment_17951", "id": "reaction_10486816", "reactome": "R-DME-6810076", "name": "DDO oxidizes D-Asp to OA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_6810061" ], "products": [ "species_113575", "species_389843", "species_6810070" ], "modifiers": [ [ "species_10486813", "catalyst" ] ], "additional_components": [ "species_113596", "Q9VM80", "FBgn0031860" ] }, "reaction_10446586": { "compartment": "compartment_17951", "id": "reaction_10446586", "reactome": "R-DME-389862", "name": "Conversion of glyoxylate to oxalate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_389678" ], "products": [ "species_389819", "species_113575" ], "modifiers": [ [ "species_10446580", "catalyst" ] ], "additional_components": [ "species_76629", "A1Z8D3", "FBgn0061356" ] }, "reaction_10481081": { "compartment": "compartment_5460", "id": "reaction_10481081", "reactome": "R-DME-6793590", "name": "LIPT2 transfers octanoyl group to GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10478187", "species_10481070" ], "products": [ "species_10481073", "species_10436440" ], "modifiers": [ [ "species_10481078", "catalyst" ] ], "additional_components": [ "FBgn0027945", "CHEBI:25650", "Q94519", "FBgn0011361", "FBgn0027945", "FBgn0011361", "FBgn0037251" ] }, "reaction_10481048": { "compartment": "compartment_5460", "id": "reaction_10481048", "reactome": "R-DME-6792572", "name": "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481032", "species_10478185" ], "products": [ "species_10481040", "species_10478187" ], "modifiers": [ [ "species_10481045", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "species_8878387", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "species_113596", "Q9VVL7", "FBgn0036762", "Q9VM14", "FBgn0283658", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "Q9VA02", "FBgn0039827", "Q9VXY3", "FBgn0030612", "Q7PLE6", "FBgn0039993", "Q9VHB8", "FBgn0037709", "FBgn0027945", "Q9VA02", "FBgn0039827", "Q7PLE6", "FBgn0039993", "Q9VHB8", "FBgn0037709", "species_8878387", "Q9VXY3", "FBgn0030612", "species_113596", "Q9VVL7", "FBgn0036762", "Q9VM14", "FBgn0283658", "Q7K5K3", "FBgn0039635", "Q9W4H4", "FBgn0029722", "Q7KVX1", "FBgn0028325", "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "FBgn0027945", "FBgn0265178" ] }, "reaction_10479511": { "compartment": "compartment_5460", "id": "reaction_10479511", "reactome": "R-DME-6784393", "name": "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784236", "species_113587" ], "products": [ "species_6784229", "species_113553" ], "modifiers": [ [ "species_10428224", "catalyst" ] ], "additional_components": [ "Q8IPY3", "FBgn0001125" ] }, "reaction_10446583": { "compartment": "compartment_17951", "id": "reaction_10446583", "reactome": "R-DME-389842", "name": "HAO1 tetramer oxidizes glycolate to glyoxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389822" ], "products": [ "species_389678", "species_113575" ], "modifiers": [ [ "species_10446580", "catalyst" ] ], "additional_components": [ "species_76629", "A1Z8D3", "FBgn0061356" ] }, "reaction_10454421": { "compartment": "compartment_5460", "id": "reaction_10454421", "reactome": "R-DME-904864", "name": "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_904849", "species_379697" ], "products": [ "species_159549", "species_113557" ], "modifiers": [ [ "species_10454418", "catalyst" ] ], "additional_components": [ "A8E6R2", "FBgn0037186" ] }, "reaction_10479508": { "compartment": "compartment_5460", "id": "reaction_10479508", "reactome": "R-DME-6784224", "name": "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6784215" ], "products": [ "species_6784241" ], "modifiers": [ [ "species_10479505", "catalyst" ] ], "additional_components": [ "Q04499", "FBgn0003423", "species_113596" ] }, "reaction_10446546": { "compartment": "compartment_17951", "id": "reaction_10446546", "reactome": "R-DME-389821", "name": "glycine + O2 => glyoxylate + H2O2 + NH4+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_141343", "species_193446" ], "products": [ "species_389678", "species_389843", "species_113575" ], "modifiers": [ [ "species_10446543", "catalyst" ] ], "additional_components": [ "Q9VM80", "FBgn0031860", "Q7JZB1", "FBgn0033543", "species_113596" ] }, "reaction_10446507": { "compartment": "compartment_17951", "id": "reaction_10446507", "reactome": "R-DME-389684", "name": "glyoxylate + alanine => glycine + pyruvate [peroxisome]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389678", "species_389664" ], "products": [ "species_389680", "species_193446" ], "modifiers": [ [ "species_10446504", "catalyst" ] ], "additional_components": [ "Q9W3Z3", "FBgn0014031" ] }, "reaction_10446571": { "compartment": "compartment_17951", "id": "reaction_10446571", "reactome": "R-DME-389826", "name": "glyoxylate + NADPH + H+ => glycolate + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_389678", "species_113602" ], "products": [ "species_389822", "species_389556" ], "modifiers": [ [ "species_10446568", "catalyst" ] ], "additional_components": [ "Q8INU6", "FBgn0051674", "Q8I725", "FBgn0037370", "Q9VII9", "FBgn0051673", "Q8SZU0", "FBgn0032889" ] }, "reaction_10481350": { "compartment": "compartment_70101", "id": "reaction_10481350", "reactome": "R-DME-6798317", "name": "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284", "species_29424" ], "products": [ "species_5359017", "species_71285" ], "modifiers": [ [ "species_10481347", "catalyst" ] ], "additional_components": [ "Q9VG42", "FBgn0038074" ] }, "reaction_10478200": { "compartment": "compartment_5460", "id": "reaction_10478200", "reactome": "R-DME-5693967", "name": "PXLP-K754-GLDC dimer decarboxylates Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_10478185" ], "products": [ "species_10478189", "species_29376" ], "modifiers": [ [ "species_10478197", "catalyst" ] ], "additional_components": [ "FBgn0027945", "Q9U616", "FBgn0027945", "CHEBI:14949", "Q9VH09", "FBgn0037801" ] }, "reaction_10478215": { "compartment": "compartment_5460", "id": "reaction_10478215", "reactome": "R-DME-5694018", "name": "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_10478202" ], "products": [ "species_113529", "species_10478185", "species_29362" ], "modifiers": [ [ "species_10478212", "catalyst" ] ], "additional_components": [ "Q9U616", "FBgn0027945", "CHEBI:50746", "FBgn0027945", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10478210": { "compartment": "compartment_5460", "id": "reaction_10478210", "reactome": "R-DME-5693977", "name": "AMT transfers NH2CH2 from GCSH:SAMDLL to THF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200671", "species_10478189" ], "products": [ "species_5693978", "species_5693984", "species_10478202" ], "modifiers": [ [ "species_10478207", "catalyst" ] ], "additional_components": [ "Q9U616", "FBgn0027945", "CHEBI:14949", "Q9U616", "FBgn0027945", "CHEBI:50746", "FBgn0032287" ] }, "reaction_10481091": { "compartment": "compartment_5460", "id": "reaction_10481091", "reactome": "R-DME-6793591", "name": "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10481073", "species_6793610", "species_2162265" ], "products": [ "species_379705", "species_6793613", "species_10478185" ], "modifiers": [ [ "species_10481088", "catalyst" ] ], "additional_components": [ "FBgn0027945", "FBgn0027945", "Q7JQW6", "FBgn0029158", "CHEBI:49883" ] }, "reaction_10428303": { "compartment": "compartment_5460", "id": "reaction_10428303", "reactome": "R-DME-70670", "name": "PRODH oxidises L-Pro to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_379717" ], "products": [ "species_113529", "species_113590", "species_164934" ], "modifiers": [ [ "species_10428300", "catalyst" ] ], "additional_components": [ "FBgn0003423" ] }, "reaction_10495134": { "compartment": "compartment_5460", "id": "reaction_10495134", "reactome": "R-DME-8955817", "name": "PRODH2 oxidises HPRO to 1PYR-5COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113597", "species_6784215" ], "products": [ "species_113590", "species_164934", "species_113521" ], "modifiers": [ [ "species_10479501", "catalyst" ] ], "additional_components": [ "FBgn0003423" ] }, "reaction_10444090": { "compartment": "compartment_70101", "id": "reaction_10444090", "reactome": "R-DME-351222", "name": "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_71284" ], "products": [ "species_353113", "species_113528" ], "modifiers": [ [ "species_10444087", "catalyst" ] ], "additional_components": [ "FBgn0019932" ] }, "reaction_10444074": { "compartment": "compartment_70101", "id": "reaction_10444074", "reactome": "R-DME-351210", "name": "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_204635" ], "products": [ "species_353560", "species_353106" ], "modifiers": [ [ "species_10444071", "catalyst" ] ], "additional_components": [ "FBgn0036272" ] }, "reaction_10444024": { "compartment": "compartment_70101", "id": "reaction_10444024", "reactome": "R-DME-350600", "name": "Antizyme inhibitor binds to OAZ and stablizes ODC complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444018", "species_10444005" ], "products": [ "species_10444022" ], "modifiers": [], "additional_components": [ "P40807", "FBgn0013307", "P40808", "FBgn0013308", "P54361", "FBgn0014184", "P40808", "FBgn0013308", "P40807", "FBgn0013307", "P40808", "FBgn0013308", "P40807", "FBgn0013307", "P54361", "FBgn0014184" ] }, "reaction_10444007": { "compartment": "compartment_70101", "id": "reaction_10444007", "reactome": "R-DME-350567", "name": "Antizyme OAZ binds to Ornithine decarboxylase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10428317", "species_10443999" ], "products": [ "species_10444005" ], "modifiers": [], "additional_components": [ "P40808", "FBgn0013308", "P40807", "FBgn0013307", "FBgn0014184", "P54361", "FBgn0014184", "P40808", "FBgn0013308", "P40807", "FBgn0013307" ] }, "reaction_10444258": { "compartment": "compartment_70101", "id": "reaction_10444258", "reactome": "R-DME-353125", "name": "26S proteosome degrades ODC holoenzyme complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444005" ], "products": [ "species_10443999" ], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "P54361", "FBgn0014184", "P40808", "FBgn0013308", "P40807", "FBgn0013307", "FBgn0014184", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10444012": { "compartment": "compartment_70101", "id": "reaction_10444012", "reactome": "R-DME-350598", "name": "Arginine<=>Agmatine+CO2", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29468" ], "products": [ "species_113528", "species_351164" ], "modifiers": [ [ "species_10444009", "catalyst" ] ], "additional_components": [ "FBgn0013307" ] }, "reaction_10444082": { "compartment": "compartment_70101", "id": "reaction_10444082", "reactome": "R-DME-351215", "name": "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353113", "species_29610" ], "products": [ "species_204635", "species_353106" ], "modifiers": [ [ "species_10444079", "catalyst" ] ], "additional_components": [ "FBgn0037723" ] }, "reaction_10428320": { "compartment": "compartment_70101", "id": "reaction_10428320", "reactome": "R-DME-70692", "name": "ornithine => putrescine + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29498" ], "products": [ "species_29610", "species_113528" ], "modifiers": [ [ "species_10428317", "catalyst" ] ], "additional_components": [ "P40808", "FBgn0013308", "P40807", "FBgn0013307" ] }, "reaction_10479998": { "compartment": "compartment_5460", "id": "reaction_10479998", "reactome": "R-DME-6788611", "name": "HYKK phosphorylates 5HLYS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788606", "species_113573" ], "products": [ "species_5696409", "species_113525" ], "modifiers": [ [ "species_10479995", "catalyst" ] ], "additional_components": [ "FBgn0086909" ] }, "reaction_10428637": { "compartment": "compartment_5460", "id": "reaction_10428637", "reactome": "R-DME-71046", "name": "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113596", "species_70955" ], "products": [ "species_71045", "species_31649", "species_29376" ], "modifiers": [ [ "species_10428634", "catalyst" ] ], "additional_components": [ "Q9VMC6", "FBgn0031824", "species_113596" ] }, "reaction_10478071": { "compartment": "compartment_17951", "id": "reaction_10478071", "reactome": "R-DME-5693347", "name": "CRYM reduces P2C to PPCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193465", "species_5693311", "species_113602" ], "products": [ "species_5693325", "species_389556" ], "modifiers": [ [ "species_10478068", "catalyst" ] ], "additional_components": [ "FBgn0030799" ] }, "reaction_10428486": { "compartment": "compartment_5460", "id": "reaction_10428486", "reactome": "R-DME-70940", "name": "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113521", "species_30176" ], "products": [ "species_113529", "species_113556", "species_29362", "species_113552" ], "modifiers": [ [ "species_10428480", "catalyst" ] ], "additional_components": [ "Q9VLX0", "FBgn0286198" ] }, "reaction_10428483": { "compartment": "compartment_5460", "id": "reaction_10428483", "reactome": "R-DME-70938", "name": "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113529", "species_29444", "species_113600" ], "products": [ "species_113563", "species_113521", "species_30176" ], "modifiers": [ [ "species_10428480", "catalyst" ] ], "additional_components": [ "Q9VLX0", "FBgn0286198" ] }, "reaction_10428627": { "compartment": "compartment_5460", "id": "reaction_10428627", "reactome": "R-DME-71037", "name": "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113526", "species_70951" ], "products": [ "species_70955", "species_29362", "species_29376" ], "modifiers": [ [ "species_10428624", "catalyst" ] ], "additional_components": [ "CHEBI:17460", "Q9VGQ1", "FBgn0037891", "species_8878387", "A8JNU6", "FBgn0010352", "Q95T35", "FBgn0035240", "species_113596", "Q9VVL7", "FBgn0036762" ] }, "reaction_10428496": { "compartment": "compartment_5460", "id": "reaction_10428496", "reactome": "R-DME-70941", "name": "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_113556", "species_113521" ], "products": [ "species_113529", "species_508531", "species_29362" ], "modifiers": [ [ "species_10428493", "catalyst" ] ], "additional_components": [ "Q8SXQ1", "FBgn0036857" ] }, "reaction_10444320": { "compartment": "compartment_5460", "id": "reaction_10444320", "reactome": "R-DME-372480", "name": "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113577" ], "products": [ "species_29406", "species_70951" ], "modifiers": [ [ "species_10444317", "catalyst" ] ], "additional_components": [ "FBgn0040383" ] }, "reaction_10481307": { "compartment": "compartment_70101", "id": "reaction_10481307", "reactome": "R-DME-6797956", "name": "SLC44A1 transports Cho from cytosol to mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_264618" ], "products": [ "species_6798162" ], "modifiers": [ [ "species_10481304", "catalyst" ] ], "additional_components": [ "FBgn0035523" ] }, "reaction_10481302": { "compartment": "compartment_5460", "id": "reaction_10481302", "reactome": "R-DME-6797955", "name": "ALDH7A1 oxidises BETALD to BET", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113526", "species_6798194", "species_113521" ], "products": [ "species_6798202", "species_29362" ], "modifiers": [ [ "species_10428491", "catalyst" ] ], "additional_components": [ "FBgn0036857" ] }, "reaction_10481299": { "compartment": "compartment_5460", "id": "reaction_10481299", "reactome": "R-DME-6797913", "name": "SARDH:FAD oxidatively demethylates SARC to Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6797917", "species_113521" ], "products": [ "species_159549", "species_6797920" ], "modifiers": [ [ "species_10481296", "catalyst" ] ], "additional_components": [ "A1ZAZ2", "FBgn0034276", "species_113596" ] }, "reaction_10460684": { "compartment": "compartment_70101", "id": "reaction_10460684", "reactome": "R-DME-1614567", "name": "Excess homocysteine yields homolanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174369" ], "products": [ "species_1614532", "species_1614594" ], "modifiers": [ [ "species_10460681", "catalyst" ], [ "species_174369", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460713": { "compartment": "compartment_70101", "id": "reaction_10460713", "reactome": "R-DME-1614631", "name": "Homocysteine is degraded to oxobutanoate and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_174369" ], "products": [ "species_1614532", "species_29382", "species_936714" ], "modifiers": [ [ "species_10460681", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460710": { "compartment": "compartment_70101", "id": "reaction_10460710", "reactome": "R-DME-1614614", "name": "Cysteine is degraded to serine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111707" ], "products": [ "species_1614532", "species_200736" ], "modifiers": [ [ "species_10460681", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10487305": { "compartment": "compartment_70101", "id": "reaction_10487305", "reactome": "R-DME-6814153", "name": "ADO oxidises 2AET to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29368", "species_6814151" ], "products": [ "species_1655445", "species_70106" ], "modifiers": [ [ "species_10487302", "catalyst" ] ], "additional_components": [ "Q9VSD8", "FBgn0035839", "species_111793" ] }, "reaction_10487307": { "compartment": "compartment_70101", "id": "reaction_10487307", "reactome": "R-DME-6814165", "name": "PXLP-K333-GADL1 decarboxylates CSA to HTAU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787748" ], "products": [ "species_1655445", "species_113528" ], "modifiers": [ [ "species_10479955", "catalyst" ] ], "additional_components": [ "Q9VPH6", "FBgn0036975", "Q24062", "FBgn0000153" ] }, "reaction_10460723": { "compartment": "compartment_70101", "id": "reaction_10460723", "reactome": "R-DME-1614645", "name": "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707", "species_29368" ], "products": [ "species_1614519" ], "modifiers": [ [ "species_10460720", "catalyst" ] ], "additional_components": [ "A1ZBA8", "FBgn0034364", "species_111793" ] }, "reaction_10460690": { "compartment": "compartment_70101", "id": "reaction_10460690", "reactome": "R-DME-1614591", "name": "Excess cysteine yields lanthionine and H2S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111707" ], "products": [ "species_1614582", "species_1614532" ], "modifiers": [ [ "species_10460681", "catalyst" ], [ "species_111707", "catalyst" ] ], "additional_components": [ "Q7JXZ2", "FBgn0000566" ] }, "reaction_10460671": { "compartment": "compartment_5460", "id": "reaction_10460671", "reactome": "R-DME-1614544", "name": "Sulfite is oxidized to sulfate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_1614538", "species_113521" ], "products": [ "species_1614617", "species_1614584" ], "modifiers": [ [ "species_10460668", "catalyst" ] ], "additional_components": [ "Q9VWP4", "FBgn0030966", "species_947539" ] }, "reaction_10460708": { "compartment": "compartment_70616", "id": "reaction_10460708", "reactome": "R-DME-1614605", "name": "Persulfide sulfur is dioxygenated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_10460696", "species_113521" ], "products": [ "species_113529", "species_10460698", "species_1614538" ], "modifiers": [ [ "species_10460705", "catalyst" ] ], "additional_components": [ "FBgn0035515", "FBgn0035515", "Q86PD3", "FBgn0050022", "species_1562550" ] }, "reaction_10438434": { "compartment": "compartment_70101", "id": "reaction_10438434", "reactome": "R-DME-174401", "name": "AHCY:NAD+ tetramer hydrolyses AdoHcy", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_71285" ], "products": [ "species_83909", "species_174369" ], "modifiers": [ [ "species_10438431", "catalyst" ] ], "additional_components": [ "species_427523", "Q27580", "FBgn0014455" ] }, "reaction_10495325": { "compartment": "compartment_70101", "id": "reaction_10495325", "reactome": "R-DME-8959510", "name": "SEPHS2 phosphorylates H2Se to form SELP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5357660", "species_29356", "species_113592" ], "products": [ "species_29372", "species_70106", "species_8959518", "species_76577" ], "modifiers": [ [ "species_10495322", "catalyst" ] ], "additional_components": [ "FBgn0261270" ] }, "reaction_10428174": { "compartment": "compartment_70101", "id": "reaction_10428174", "reactome": "R-DME-70569", "name": "arginine + H2O => ornithine + urea [ARG1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29468" ], "products": [ "species_29514", "species_29498" ], "modifiers": [ [ "species_10428171", "catalyst" ] ], "additional_components": [ "O76895", "FBgn0023535", "species_266099" ] }, "reaction_10428184": { "compartment": "compartment_70101", "id": "reaction_10428184", "reactome": "R-DME-70573", "name": "argininosuccinate <=> fumarate + arginine", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_34575" ], "products": [ "species_29468", "species_29586" ], "modifiers": [ [ "species_10428181", "catalyst" ] ], "additional_components": [ "Q9VLG9", "FBgn0032076" ] }, "reaction_10451632": { "compartment": "compartment_5460", "id": "reaction_10451632", "reactome": "R-DME-452036", "name": "arginine + H2O => ornithine + urea [ARG2]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_374064", "species_113521" ], "products": [ "species_374061", "species_113585" ], "modifiers": [ [ "species_10451629", "catalyst" ] ], "additional_components": [ "O76895", "FBgn0023535", "species_266099" ] }, "reaction_10428272": { "compartment": "compartment_70101", "id": "reaction_10428272", "reactome": "R-DME-70634", "name": "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113567", "species_29498" ], "products": [ "species_113585", "species_29968" ], "modifiers": [ [ "species_10428269", "catalyst" ] ], "additional_components": [ "FBgn0030218" ] }, "reaction_10428283": { "compartment": "compartment_5460", "id": "reaction_10428283", "reactome": "R-DME-70654", "name": "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113594", "species_113585" ], "products": [ "species_31339", "species_113552" ], "modifiers": [ [ "species_10428280", "catalyst" ] ], "additional_components": [ "Q9VW26", "FBgn0022774" ] }, "reaction_10453130": { "compartment": "compartment_5460", "id": "reaction_10453130", "reactome": "R-DME-508040", "name": "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113593", "species_113600", "species_113552" ], "products": [ "species_113548", "species_113581", "species_31339", "species_113563" ], "modifiers": [ [ "species_10453127", "catalyst" ] ], "additional_components": [ "Q9VNW6", "FBgn0037146" ] }, "reaction_10479495": { "compartment": "compartment_70101", "id": "reaction_10479495", "reactome": "R-DME-6783955", "name": "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_35305", "species_29364" ], "products": [ "species_29366", "species_113538" ], "modifiers": [ [ "species_10479492", "catalyst" ] ], "additional_components": [ "Q9VEJ3", "FBgn0038516" ] }, "reaction_10428214": { "compartment": "compartment_5460", "id": "reaction_10428214", "reactome": "R-DME-70589", "name": "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "products": [ "species_113552", "species_113521", "species_517495" ], "modifiers": [ [ "species_10428211", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_29364", "species_29362", "species_427523", "species_29366", "P54385", "FBgn0001098" ] }, "reaction_10428293": { "compartment": "compartment_5460", "id": "reaction_10428293", "reactome": "R-DME-70664", "name": "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10428290", "catalyst" ] ], "additional_components": [ "Q9VEJ3", "FBgn0038516" ] }, "reaction_10428229": { "compartment": "compartment_5460", "id": "reaction_10428229", "reactome": "R-DME-70600", "name": "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113552", "species_113521", "species_517495" ], "products": [ "species_517496", "species_113594", "species_113529", "species_113561" ], "modifiers": [ [ "species_10428211", "catalyst" ], [ "species_113581", "catalyst" ], [ "species_113573", "inhibitor" ] ], "additional_components": [ "species_427523", "species_29366", "species_29364", "species_29362", "P54385", "FBgn0001098" ] }, "reaction_10454402": { "compartment": "compartment_70101", "id": "reaction_10454402", "reactome": "R-DME-893616", "name": "glutamine + pyruvate => 2-oxoglutaramate + alanine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29398", "species_29472" ], "products": [ "species_29432", "species_893598" ], "modifiers": [ [ "species_10454393", "catalyst" ] ], "additional_components": [ "Q8SXC2", "FBgn0037955" ] }, "reaction_10479488": { "compartment": "compartment_5460", "id": "reaction_10479488", "reactome": "R-DME-6783939", "name": "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113529", "species_113590", "species_29362" ], "products": [ "species_113526", "species_379717" ], "modifiers": [ [ "species_10479485", "catalyst" ] ], "additional_components": [ "Q9VEJ3", "FBgn0038516" ] }, "reaction_10428750": { "compartment": "compartment_5460", "id": "reaction_10428750", "reactome": "R-DME-71241", "name": "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113594", "species_35139" ], "products": [ "species_113546", "species_113536", "species_29376" ], "modifiers": [ [ "species_10428747", "catalyst" ] ], "additional_components": [ "species_351595", "Q9VDM7", "FBgn0038795", "species_111793" ] }, "reaction_10428761": { "compartment": "compartment_70101", "id": "reaction_10428761", "reactome": "R-DME-71249", "name": "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_31503" ], "products": [ "species_31311", "species_29424" ], "modifiers": [ [ "species_10428758", "catalyst" ] ], "additional_components": [ "Q9W457", "FBgn0029823" ] }, "reaction_10442782": { "compartment": "compartment_984", "id": "reaction_10442782", "reactome": "R-DME-209840", "name": "Two DITs combine to form thyroxine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329" ], "products": [ "species_352326", "species_352036" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10478122": { "compartment": "compartment_876", "id": "reaction_10478122", "reactome": "R-DME-5693681", "name": "DUOX1,2 reduce O2 to H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352327" ], "products": [ "species_351628", "species_351629" ], "modifiers": [ [ "species_10478117", "catalyst" ] ], "additional_components": [ "FBgn0283531" ] }, "reaction_10442841": { "compartment": "compartment_984", "id": "reaction_10442841", "reactome": "R-DME-209973", "name": "Tyrosine is diiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_352030", "species_209818", "species_351629" ], "products": [ "species_109276", "species_352329", "species_351628" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10444056": { "compartment": "compartment_984", "id": "reaction_10444056", "reactome": "R-DME-350901", "name": "Iodide is organified", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351626", "species_351627", "species_209818", "species_351629" ], "products": [ "species_109276", "species_351630", "species_351628" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10442823": { "compartment": "compartment_876", "id": "reaction_10442823", "reactome": "R-DME-209910", "name": "Iodide is taken up by thyroid epithelial cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209818", "species_74113" ], "products": [ "species_209785", "species_83910" ], "modifiers": [ [ "species_10442820", "catalyst" ] ], "additional_components": [ "P83740", "FBgn0052669", "Q8SWV5", "FBgn0034494" ] }, "reaction_10442839": { "compartment": "compartment_984", "id": "reaction_10442839", "reactome": "R-DME-209960", "name": "Diiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_352329" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10442830", "catalyst" ] ], "additional_components": [ "Q9VTE7", "FBgn0036125", "species_76629" ] }, "reaction_10442758": { "compartment": "compartment_984", "id": "reaction_10442758", "reactome": "R-DME-209815", "name": "Tyrosine is monoiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351630", "species_352030" ], "products": [ "species_622410", "species_351639" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10442837": { "compartment": "compartment_984", "id": "reaction_10442837", "reactome": "R-DME-209925", "name": "DIT and MIT combine to form triiodothyronine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352329", "species_351639" ], "products": [ "species_352331", "species_352036" ], "modifiers": [ [ "species_10442755", "catalyst" ] ], "additional_components": [ "FBgn0011828" ] }, "reaction_10442833": { "compartment": "compartment_984", "id": "reaction_10442833", "reactome": "R-DME-209921", "name": "Monoiodinated tyrosine can be deiodinated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351627", "species_351639" ], "products": [ "species_352030", "species_351628", "species_209818" ], "modifiers": [ [ "species_10442830", "catalyst" ] ], "additional_components": [ "Q9VTE7", "FBgn0036125", "species_76629" ] }, "reaction_10442808": { "compartment": "compartment_1462052", "id": "reaction_10442808", "reactome": "R-DME-209891", "name": "Dopamine is oxidised to noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_351595", "species_351593", "species_351601" ], "products": [ "species_351599", "species_351597", "species_351603" ], "modifiers": [ [ "species_10442805", "catalyst" ] ], "additional_components": [ "CHEBI:28694", "Q86B61", "FBgn0010329", "CHEBI:18315" ] }, "reaction_10442835": { "compartment": "compartment_70101", "id": "reaction_10442835", "reactome": "R-DME-209924", "name": "Dopa is decarboxylated to dopamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209849" ], "products": [ "species_113528", "species_159362" ], "modifiers": [ [ "species_10442795", "catalyst" ] ], "additional_components": [ "P05031", "FBgn0000422" ] }, "reaction_10442768": { "compartment": "compartment_70101", "id": "reaction_10442768", "reactome": "R-DME-209823", "name": "Tyrosine is hydroxylated to dopa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29870", "species_29368", "species_29506" ], "products": [ "species_209849", "species_71112" ], "modifiers": [ [ "species_10442765", "catalyst" ] ], "additional_components": [ "P18459", "FBgn0005626", "species_111793" ] }, "reaction_10443240": { "compartment": "compartment_17960", "id": "reaction_10443240", "reactome": "R-DME-211962", "name": "CYP4F11 16-hydroxylates 3OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_216621", "species_113601" ], "products": [ "species_113519", "species_113564", "species_216612" ], "modifiers": [ [ "species_10443237", "catalyst" ] ], "additional_components": [ "Q27589", "FBgn0011576" ] }, "reaction_10443235": { "compartment": "compartment_17960", "id": "reaction_10443235", "reactome": "R-DME-211960", "name": "CYP2U1 19-hydroxylates ARA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_216620", "species_113519", "species_113564" ], "modifiers": [ [ "species_10443232", "catalyst" ] ], "additional_components": [ "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10443248": { "compartment": "compartment_17960", "id": "reaction_10443248", "reactome": "R-DME-211968", "name": "CYP2W1 oxidises INDOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_113601", "species_216547" ], "products": [ "species_113519", "species_113564", "species_216598" ], "modifiers": [ [ "species_10443245", "catalyst" ] ], "additional_components": [ "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10443226": { "compartment": "compartment_5460", "id": "reaction_10443226", "reactome": "R-DME-211950", "name": "CYP24A1 24-hydroxylates CTL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113529", "species_215607", "species_113600" ], "products": [ "species_113563", "species_215622", "species_113521" ], "modifiers": [ [ "species_10442747", "catalyst" ] ], "additional_components": [ "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053" ] }, "reaction_10442787": { "compartment": "compartment_70101", "id": "reaction_10442787", "reactome": "R-DME-209845", "name": "CYP2R1 25-hydroxylates VD3 to 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_8963870", "species_29364" ], "products": [ "species_8963879", "species_29356", "species_29366" ], "modifiers": [ [ "species_10442784", "catalyst" ] ], "additional_components": [ "FBgn0004959" ] }, "reaction_10443163": { "compartment": "compartment_12045", "id": "reaction_10443163", "reactome": "R-DME-211873", "name": "CYP4F2, 4F3 20-hydroxylate LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266056", "species_70106", "species_29368", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2161636" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10472838": { "compartment": "compartment_12045", "id": "reaction_10472838", "reactome": "R-DME-5602295", "name": "CYP4F22 20-hydroxylates TrXA3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_2142713", "species_29368", "species_29364" ], "products": [ "species_5602281", "species_29356", "species_29366" ], "modifiers": [ [ "species_10433053", "catalyst" ] ], "additional_components": [ "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397" ] }, "reaction_10443219": { "compartment": "compartment_17960", "id": "reaction_10443219", "reactome": "R-DME-211919", "name": "CYP4F8 19-hydroxylates PGH2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_30138", "species_113601" ], "products": [ "species_113519", "species_113564", "species_215545" ], "modifiers": [ [ "species_10443216", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10443328": { "compartment": "compartment_17960", "id": "reaction_10443328", "reactome": "R-DME-215526", "name": "CYP4F3 20-hydroxylates LTB4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_215557", "species_113601" ], "products": [ "species_113519", "species_113564", "species_571314" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10435630": { "compartment": "compartment_70101", "id": "reaction_10435630", "reactome": "R-DME-158447", "name": "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430485", "species_10435624" ], "products": [ "species_10432289", "species_10432313", "species_10435628" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "FBgn0003321", "FBgn0010774", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10433293": { "compartment": "compartment_7660", "id": "reaction_10433293", "reactome": "R-DME-77594", "name": "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433289", "species_10429500", "species_10432253" ], "products": [ "species_10429169", "species_10433291", "species_10429982" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "FBgn0010774", "FBgn0003321", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9V726", "FBgn0024698", "Q9VN31", "FBgn0037255", "Q9VNG2", "FBgn0046222", "Q9VE51", "FBgn0261065", "Q8MSU4", "FBgn0037371", "Q9V3D6", "FBgn0027873", "Q9VPT8", "FBgn0015621", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435626": { "compartment": "compartment_13231", "id": "reaction_10435626", "reactome": "R-DME-158441", "name": "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433291" ], "products": [ "species_10435624" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435660": { "compartment": "compartment_70101", "id": "reaction_10435660", "reactome": "R-DME-158484", "name": "Release of the SLBP independent Histone mRNA from the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430485", "species_10435654" ], "products": [ "species_10432289", "species_10432313", "species_10435658" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "FBgn0003321", "FBgn0010774", "P48598", "eIF4E1", "Q9VRY0", "FBgn0035709", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10434122": { "compartment": "compartment_7660", "id": "reaction_10434122", "reactome": "R-DME-111439", "name": "Docking of Mature Histone mRNA complex:TAP at the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434114", "species_10429500", "species_10432253" ], "products": [ "species_10429169", "species_10434120" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "FBgn0010774", "FBgn0003321", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10435656": { "compartment": "compartment_13231", "id": "reaction_10435656", "reactome": "R-DME-158481", "name": "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434120" ], "products": [ "species_10435654" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9V3E7", "FBgn0010774", "Q9V3E7", "FBgn0010774", "Q9U1H9", "FBgn0003321", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10450430": { "compartment": "compartment_70101", "id": "reaction_10450430", "reactome": "R-DME-446185", "name": "Isomerization of GlcNAc6P to GlcNAc1P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449703" ], "products": [ "species_532204" ], "modifiers": [ [ "species_10450427", "catalyst" ] ], "additional_components": [ "FBgn0036298" ] }, "reaction_10485958": { "compartment": "compartment_70101", "id": "reaction_10485958", "reactome": "R-DME-6803789", "name": "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6803743" ], "products": [ "species_193473", "species_449701" ], "modifiers": [ [ "species_10485955", "catalyst" ] ], "additional_components": [ "FBgn0031099" ] }, "reaction_10450504": { "compartment": "compartment_70101", "id": "reaction_10450504", "reactome": "R-DME-446204", "name": "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29494", "species_532204" ], "products": [ "species_111294", "species_162756" ], "modifiers": [ [ "species_10450501", "catalyst" ] ], "additional_components": [ "Q9Y0Z0", "FBgn0259749" ] }, "reaction_10450806": { "compartment": "compartment_70101", "id": "reaction_10450806", "reactome": "R-DME-449715", "name": "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29512", "species_29472" ], "products": [ "species_29404", "species_449701" ], "modifiers": [ [ "species_10450803", "catalyst" ] ], "additional_components": [ "Q9VAW3", "FBgn0039580", "Q7PLC7", "FBgn0287209" ] }, "reaction_10485950": { "compartment": "compartment_70101", "id": "reaction_10485950", "reactome": "R-DME-6803771", "name": "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803785", "species_113592" ], "products": [ "species_6803738", "species_70106", "species_29370" ], "modifiers": [ [ "species_10485947", "catalyst" ] ], "additional_components": [ "CHEBI:27459", "species_1678743", "species_449703", "species_6803743", "Q9VF86", "FBgn0038321" ] }, "reaction_10450816": { "compartment": "compartment_70101", "id": "reaction_10450816", "reactome": "R-DME-449734", "name": "Acetylation of glucosamine 6-phosphate to GlcNAc6P", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76183", "species_449701" ], "products": [ "species_76194", "species_449703" ], "modifiers": [ [ "species_10450813", "catalyst" ] ], "additional_components": [ "Q9VAI0", "FBgn0039690" ] }, "reaction_10457936": { "compartment": "compartment_1222693", "id": "reaction_10457936", "reactome": "R-DME-1222516", "name": "Intraphagosomal pH is lowered to 5 by V-ATPase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106" ], "products": [ "species_1470067" ], "modifiers": [ [ "species_10457933", "catalyst" ] ], "additional_components": [ "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9VFE3", "FBgn0028662", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VEQ6", "FBgn0038458", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "P23380", "FBgn0262736" ] }, "reaction_10465115": { "compartment": "compartment_12045", "id": "reaction_10465115", "reactome": "R-DME-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142780" ], "modifiers": [ [ "species_10465112", "catalyst" ] ], "additional_components": [ "Q9VXY0", "FBgn0030615", "Q9V557", "FBgn0033395", "Q9VLZ7", "FBgn0031925", "O46051", "FBgn0023541", "Q9VVN6", "FBgn0036778", "Q9V4T5", "FBgn0015034", "Q9VL92", "FBgn0015035", "Q9VS79", "FBgn0015033", "Q9V4T3", "FBgn0033292", "Q9VGH1", "FBgn0003312", "Q9VS78", "FBgn0035790", "Q27606", "FBgn0014469", "Q9V7G5", "FBgn0034053", "Q9VMS9", "FBgn0031693", "Q27589", "FBgn0011576", "Q9W011", "FBgn0035344", "Q9V559", "FBgn0033397", "Q9VMS8", "FBgn0031694", "P33269", "FBgn0005670", "Q9VYQ7", "FBgn0030367", "Q9V558", "FBgn0015037", "Q9VMS7", "FBgn0031695", "O46054", "FBgn0015036", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10465105": { "compartment": "compartment_12045", "id": "reaction_10465105", "reactome": "R-DME-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_156540", "species_140356", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2142836" ], "modifiers": [ [ "species_10465102", "catalyst" ] ], "additional_components": [ "Q9VXY0", "FBgn0030615", "Q9V557", "FBgn0033395", "Q9VLZ7", "FBgn0031925", "O46051", "FBgn0023541", "Q9VVN6", "FBgn0036778", "Q9V4T5", "FBgn0015034", "Q9VL92", "FBgn0015035", "Q9VS79", "FBgn0015033", "Q9V4T3", "FBgn0033292", "Q9VGH1", "FBgn0003312", "Q9VS78", "FBgn0035790", "Q27606", "FBgn0014469", "Q9V7G5", "FBgn0034053", "Q9VMS9", "FBgn0031693", "Q27589", "FBgn0011576", "Q9W011", "FBgn0035344", "Q9V559", "FBgn0033397", "Q9VMS8", "FBgn0031694", "P33269", "FBgn0005670", "Q9VYQ7", "FBgn0030367", "Q9V558", "FBgn0015037", "Q9VMS7", "FBgn0031695", "O46054", "FBgn0015036", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_350385": { "compartment": "compartment_876", "id": "reaction_350385", "reactome": "R-DME-350385", "name": "DSH binds to RAC1:GTP", "reversible": "false", "notes": "The DEP domain of Dishevelled (DSH) binds to activated Rac GTPase (RAC1:GTP).", "reactants": [ "species_351067", "species_450734" ], "products": [ "species_450786" ], "modifiers": [], "additional_components": [ "P40792", "RAC1_DROME", "species_29438", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "P40792", "RAC1_DROME", "species_29438", "A1Z6W3", "PK" ] }, "reaction_450723": { "compartment": "compartment_70101", "id": "reaction_450723", "reactome": "R-DME-450723", "name": "RAC1:GTP and MSN activate HEP", "reversible": "false", "notes": "Activated RAC1:GTP and the MAP kinase kinase kinase kinase (MKKKK) orthologue Misshapen (MSN) are involved in phosphorylating and activating the MKK orthologue Hemipterous (HEP). It is likely that a MKKK orthologue, currently unknown, is involved in directly phosphorylating HEP.", "reactants": [ "species_113592", "species_206293" ], "products": [ "species_29370", "species_205776" ], "modifiers": [ [ "species_450710", "catalyst" ], [ "species_450786", "catalyst" ] ], "additional_components": [ "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "P40792", "RAC1_DROME", "species_29438", "A1Z6W3", "PK" ] }, "reaction_10450527": { "compartment": "compartment_12045", "id": "reaction_10450527", "reactome": "R-DME-446208", "name": "Addition of a second mannose to the N-glycan precursor by ALG2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449283" ], "products": [ "species_449737", "species_29420" ], "modifiers": [ [ "species_10450524", "catalyst" ] ], "additional_components": [ "FBgn0035401" ] }, "reaction_10450543": { "compartment": "compartment_17957", "id": "reaction_10450543", "reactome": "R-DME-446215", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449315" ], "products": [ "species_449311", "species_449312" ], "modifiers": [ [ "species_10450540", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0039293", "FBgn0031662" ] }, "reaction_10450494": { "compartment": "compartment_17957", "id": "reaction_10450494", "reactome": "R-DME-446202", "name": "Addition of the first glucose to the N-glycan precursor by ALG6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449371", "species_532542" ], "products": [ "species_449311", "species_449649" ], "modifiers": [ [ "species_10450491", "catalyst" ] ], "additional_components": [ "FBgn0032234" ] }, "reaction_10450535": { "compartment": "compartment_12045", "id": "reaction_10450535", "reactome": "R-DME-446214", "name": "Synthesis of dolichyl-phosphate-glucose", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449299", "species_29410" ], "products": [ "species_532214", "species_110096" ], "modifiers": [ [ "species_10450532", "catalyst" ] ], "additional_components": [ "FBgn0261020" ] }, "reaction_10486907": { "compartment": "compartment_70101", "id": "reaction_10486907", "reactome": "R-DME-6810464", "name": "NUDT14 hydrolyses UDP-Glc to G1P and UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_29410" ], "products": [ "species_29548", "species_109402" ], "modifiers": [ [ "species_10486904", "catalyst" ] ], "additional_components": [ "FBgn0261995" ] }, "reaction_10479928": { "compartment": "compartment_70101", "id": "reaction_10479928", "reactome": "R-DME-6787623", "name": "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6787618" ], "products": [ "species_6787646" ], "modifiers": [ [ "species_10479925", "catalyst" ] ], "additional_components": [ "Q9W1X8", "FBgn0267823" ] }, "reaction_10479939": { "compartment": "compartment_70101", "id": "reaction_10479939", "reactome": "R-DME-6787642", "name": "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_6787646", "species_29364" ], "products": [ "species_742368", "species_29366" ], "modifiers": [ [ "species_10479925", "catalyst" ] ], "additional_components": [ "Q9W1X8", "FBgn0267823" ] }, "reaction_10479936": { "compartment": "compartment_70101", "id": "reaction_10479936", "reactome": "R-DME-6787632", "name": "GMDS dehydrates GDP-Man to GDP-DHDMan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860" ], "products": [ "species_29356", "species_6787618" ], "modifiers": [ [ "species_10479933", "catalyst" ] ], "additional_components": [ "FBgn0031661" ] }, "reaction_10469805": { "compartment": "compartment_12045", "id": "reaction_10469805", "reactome": "R-DME-4419979", "name": "SRD5A3 reduces pPNOL to DCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_4419981", "species_29364" ], "products": [ "species_29366", "species_449221" ], "modifiers": [ [ "species_10469802", "catalyst" ] ], "additional_components": [ "FBgn0032014" ] }, "reaction_10469797": { "compartment": "compartment_12045", "id": "reaction_10469797", "reactome": "R-DME-4419978", "name": "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_191362", "species_4419987" ], "products": [ "species_4419982" ], "modifiers": [ [ "species_10469794", "catalyst" ] ], "additional_components": [ "Q9W3M6", "FBgn0029980", "Q9VPX8", "FBgn0031312" ] }, "reaction_10450468": { "compartment": "compartment_12045", "id": "reaction_10450468", "reactome": "R-DME-446195", "name": "DOLK phosphorylates DCHOL to DOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_110614", "species_449221" ], "products": [ "species_110094", "species_449299" ], "modifiers": [ [ "species_10450465", "catalyst" ] ], "additional_components": [ "FBgn0034141" ] }, "reaction_10450460": { "compartment": "compartment_12045", "id": "reaction_10450460", "reactome": "R-DME-446191", "name": "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449299" ], "products": [ "species_109402", "species_449222" ], "modifiers": [ [ "species_10450457", "catalyst" ] ], "additional_components": [ "FBgn0032477" ] }, "reaction_10450476": { "compartment": "compartment_17957", "id": "reaction_10450476", "reactome": "R-DME-446198", "name": "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449312" ], "products": [ "species_449311", "species_449365" ], "modifiers": [ [ "species_10450473", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0037743", "FBgn0031662" ] }, "reaction_10450443": { "compartment": "compartment_17957", "id": "reaction_10450443", "reactome": "R-DME-446188", "name": "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449298" ], "products": [ "species_449311", "species_449315" ], "modifiers": [ [ "species_10450435", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0011297", "FBgn0031662" ] }, "reaction_10450553": { "compartment": "compartment_12045", "id": "reaction_10450553", "reactome": "R-DME-446218", "name": "Addition of the first mannose to the N-glycan precursor by ALG1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162860", "species_449293" ], "products": [ "species_29420", "species_449283" ], "modifiers": [ [ "species_10450550", "catalyst" ] ], "additional_components": [ "FBgn0038552" ] }, "reaction_10450519": { "compartment": "compartment_12045", "id": "reaction_10450519", "reactome": "R-DME-446207", "name": "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_162756", "species_449222" ], "products": [ "species_449293", "species_110096" ], "modifiers": [ [ "species_10450516", "catalyst" ] ], "additional_components": [ "Q9VAP1", "FBgn0039639", "Q9VXU7", "FBgn0030645" ] }, "reaction_10450452": { "compartment": "compartment_17957", "id": "reaction_10450452", "reactome": "R-DME-446189", "name": "Addition of a second glucose to the N-glycan precursor by ALG8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449649", "species_532542" ], "products": [ "species_449311", "species_449638" ], "modifiers": [ [ "species_10450449", "catalyst" ] ], "additional_components": [ "FBgn0029906" ] }, "reaction_10450545": { "compartment": "compartment_17957", "id": "reaction_10450545", "reactome": "R-DME-446216", "name": "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_449229", "species_449365" ], "products": [ "species_449371", "species_449311" ], "modifiers": [ [ "species_10450540", "catalyst" ], [ "species_10450441", "catalyst" ] ], "additional_components": [ "FBgn0039293", "FBgn0031662" ] }, "reaction_10435743": { "compartment": "compartment_7660", "id": "reaction_10435743", "reactome": "R-DME-159101", "name": "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435738", "species_10432271" ], "products": [ "species_113550", "species_10432277", "species_10435740" ], "modifiers": [ [ "species_10435738", "catalyst" ] ], "additional_components": [ "Q02427", "FBgn0260944", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q9V3V0", "FBgn0028554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q9U1H9", "FBgn0003321", "Q9VV73", "FBgn0036640", "Q8IQK4", "FBgn0263232", "Q9V3H8", "FBgn0028411", "Q9U1H9", "FBgn0003321", "Q9VV73", "FBgn0036640", "Q8IQK4", "FBgn0263232", "Q9V3H8", "FBgn0028411", "Q02427", "FBgn0260944", "Q9VD52", "FBgn0038927", "Q9V3T8", "FBgn0265298", "Q9VY54", "FBgn0026713", "P26686", "FBgn0004587", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3V0", "FBgn0028554", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9V3E7", "FBgn0010774", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411", "Q27268", "FBgn0014189", "species_29370", "Q02427", "FBgn0260944", "Q9V3T8", "FBgn0265298", "Q9VD52", "FBgn0038927", "P26686", "FBgn0004587", "Q9VY54", "FBgn0026713", "Q9V3V0", "FBgn0028554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q27268", "FBgn0014189", "species_113592", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9VHC8", "FBgn0037700", "Q9VHT2", "FBgn0037569", "Q8IRJ8", "FBgn0035110", "E2QCS8", "FBgn0031390", "Q9VTV1", "FBgn0036263", "Q9VNI8", "FBgn0037382", "Q9W1F4", "FBgn0034939", "Q9VL71", "FBgn0024285", "Q9V3W7", "FBgn0283477", "Q94535", "FBgn0017457", "Q9VAQ7", "FBgn0039626", "Q9VF55", "FBgn0038345", "Q24562", "FBgn0005411" ] }, "reaction_10432342": { "compartment": "compartment_70101", "id": "reaction_10432342", "reactome": "R-DME-75098", "name": "mRNP complex dissociates from cytosolic face of NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432329" ], "products": [ "species_10432243", "species_10432340", "species_10432301" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3H8", "FBgn0028411", "Q9VV73", "FBgn0036640", "Q9U1H9", "FBgn0003321", "Q8IQK4", "FBgn0263232", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VHC0", "FBgn0037707", "Q9V3E7", "FBgn0010774", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VHC0", "FBgn0037707", "Q9V3E7", "FBgn0010774", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3H8", "FBgn0028411", "Q9VV73", "FBgn0036640", "Q9U1H9", "FBgn0003321", "Q8IQK4", "FBgn0263232", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10432336": { "compartment": "compartment_13231", "id": "reaction_10432336", "reactome": "R-DME-75097", "name": "Transport of the export-competent mRNP complex through the NPC", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432279" ], "products": [ "species_10432329" ], "modifiers": [ [ "species_10432243", "catalyst" ], [ "species_10432334", "catalyst" ] ], "additional_components": [ "Q9U1H9", "FBgn0003321", "Q9VV73", "FBgn0036640", "Q8IQK4", "FBgn0263232", "Q9V3H8", "FBgn0028411", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9V3E7", "FBgn0010774", "Q9VHC0", "FBgn0037707", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3H8", "FBgn0028411", "Q9VV73", "FBgn0036640", "Q9U1H9", "FBgn0003321", "Q8IQK4", "FBgn0263232", "Q9VWQ6", "FBgn0030956", "Q9VWQ3", "FBgn0030959", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "Q9W1H3", "FBgn0034923", "Q9VU43", "FBgn0036340", "Q9VHC0", "FBgn0037707", "Q9V3E7", "FBgn0010774", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200", "FBgn0033316" ] }, "reaction_10439582": { "compartment": "compartment_17927", "id": "reaction_10439582", "reactome": "R-DME-189421", "name": "CPO transforms COPRO3 to PPGEN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189411" ], "products": [ "species_189481", "species_189480", "species_189478" ], "modifiers": [ [ "species_10439579", "catalyst" ] ], "additional_components": [ "Q9V3D2", "FBgn0021944" ] }, "reaction_10467261": { "compartment": "compartment_5460", "id": "reaction_10467261", "reactome": "R-DME-2995334", "name": "COX15 transforms heme O to heme A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2995328" ], "products": [ "species_2995348" ], "modifiers": [ [ "species_10467258", "catalyst" ] ], "additional_components": [ "FBgn0034938" ] }, "reaction_10439612": { "compartment": "compartment_70101", "id": "reaction_10439612", "reactome": "R-DME-189439", "name": "ALAD condenses 2 dALAs to form PBG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189489" ], "products": [ "species_29356", "species_70106", "species_189464" ], "modifiers": [ [ "species_10439609", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VTV9", "FBgn0036271" ] }, "reaction_10439640": { "compartment": "compartment_5460", "id": "reaction_10439640", "reactome": "R-DME-189465", "name": "FECH binds Fe2+ to PRIN9 to form heme", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189487", "species_113531" ], "products": [ "species_113529", "species_189444" ], "modifiers": [ [ "species_10439637", "catalyst" ], [ "species_391232", "inhibitor" ] ], "additional_components": [ "Q9V9S8", "FBgn0266268" ] }, "reaction_10455127": { "compartment": "compartment_876", "id": "reaction_10455127", "reactome": "R-DME-917979", "name": "ABCG2 tetramer transports heme from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_71185" ], "products": [ "species_29372", "species_917877", "species_29370" ], "modifiers": [ [ "species_10455124", "catalyst" ] ], "additional_components": [ "P45843", "FBgn0003515", "P12428", "FBgn0000241", "Q0KI14", "FBgn0051121" ] }, "reaction_10467253": { "compartment": "compartment_5460", "id": "reaction_10467253", "reactome": "R-DME-2995330", "name": "COX10 transforms heme to heme O", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189444", "species_2162257", "species_113521" ], "products": [ "species_2995328", "species_159450" ], "modifiers": [ [ "species_10467250", "catalyst" ] ], "additional_components": [ "FBgn0032222" ] }, "reaction_10439572": { "compartment": "compartment_70101", "id": "reaction_10439572", "reactome": "R-DME-189406", "name": "4 PBGs bind to form HMB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_189464" ], "products": [ "species_189449", "species_31633" ], "modifiers": [ [ "species_10439569", "catalyst" ] ], "additional_components": [ "Q9W0G4", "FBgn0010786", "CHEBI:36319" ] }, "reaction_10439602": { "compartment": "compartment_70101", "id": "reaction_10439602", "reactome": "R-DME-189425", "name": "UROD decarboxylates URO3 to COPRO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189407" ], "products": [ "species_189455", "species_113528" ], "modifiers": [ [ "species_10439599", "catalyst" ] ], "additional_components": [ "Q9V595", "FBgn0033428" ] }, "reaction_10439630": { "compartment": "compartment_5460", "id": "reaction_10439630", "reactome": "R-DME-189442", "name": "ALAS condenses SUCC-CoA and Gly to form dALA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159549", "species_70958", "species_113529" ], "products": [ "species_29374", "species_189466", "species_29376" ], "modifiers": [ [ "species_10439627", "catalyst" ], [ "species_189444", "inhibitor" ] ], "additional_components": [ "O18680", "FBgn0020764" ] }, "reaction_10439592": { "compartment": "compartment_17927", "id": "reaction_10439592", "reactome": "R-DME-189423", "name": "PPO oxidises PPGEN9 to PRIN9", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189461", "species_189478" ], "products": [ "species_189481", "species_189463" ], "modifiers": [ [ "species_10439589", "catalyst" ] ], "additional_components": [ "Q9VC52", "FBgn0020018", "species_113596" ] }, "reaction_10439654": { "compartment": "compartment_70101", "id": "reaction_10439654", "reactome": "R-DME-190182", "name": "UROD decarboxylates URO1 to COPRO1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190157" ], "products": [ "species_113528", "species_190128" ], "modifiers": [ [ "species_10439599", "catalyst" ] ], "additional_components": [ "Q9V595", "FBgn0033428" ] }, "reaction_10439652": { "compartment": "compartment_70101", "id": "reaction_10439652", "reactome": "R-DME-190141", "name": "ALAD binds to Pb2+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_190173", "species_10439609" ], "products": [ "species_10439650", "species_29426" ], "modifiers": [], "additional_components": [ "species_1562550", "Q9VTV9", "FBgn0036271", "species_1562550", "Q9VTV9", "FBgn0036271", "species_190173" ] }, "reaction_10439648": { "compartment": "compartment_70101", "id": "reaction_10439648", "reactome": "R-DME-189488", "name": "UROS transforms HMB to URO3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189449" ], "products": [ "species_189407", "species_29356" ], "modifiers": [ [ "species_10439645", "catalyst" ] ], "additional_components": [ "FBgn0030066" ] }, "reaction_10453037": { "compartment": "compartment_876", "id": "reaction_10453037", "reactome": "R-DME-499981", "name": "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70115" ], "products": [ "species_70113" ], "modifiers": [ [ "species_10453034", "catalyst" ] ], "additional_components": [ "Q7KJP2", "FBgn0028561", "Q0IGX4", "FBgn0033047", "Q9U622", "FBgn0028562", "Q7KK97", "FBgn0028563", "Q8IRI6", "FBgn0264574" ] }, "reaction_10447180": { "compartment": "compartment_876", "id": "reaction_10447180", "reactome": "R-DME-399998", "name": "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10447177", "catalyst" ] ], "additional_components": [ "species_29438" ] }, "reaction_10443692": { "compartment": "compartment_876", "id": "reaction_10443692", "reactome": "R-DME-265645", "name": "Calcium Influx through Voltage-gated Calcium Channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10443689", "catalyst" ] ], "additional_components": [ "X2J9Z3", "FBgn0028863", "Q8IP22", "FBgn0261999", "Q24270", "FBgn0001991", "P91645", "FBgn0263111" ] }, "reaction_10449645": { "compartment": "compartment_876", "id": "reaction_10449645", "reactome": "R-DME-434381", "name": "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_400452" ], "products": [ "species_3632881" ], "modifiers": [ [ "species_10449642", "catalyst" ] ], "additional_components": [ "FBgn0035815" ] }, "reaction_10447214": { "compartment": "compartment_876", "id": "reaction_10447214", "reactome": "R-DME-400092", "name": "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10447212" ], "products": [ "species_29420", "species_10447204" ], "modifiers": [ [ "species_10445696", "catalyst" ] ], "additional_components": [ "species_29420", "species_29438", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10447208": { "compartment": "compartment_876", "id": "reaction_10447208", "reactome": "R-DME-400071", "name": "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390627", "species_10445692" ], "products": [ "species_10445696" ], "modifiers": [], "additional_components": [ "CHEBI:28918", "species_351597", "FBgn0004514", "P22270", "FBgn0004514", "CHEBI:28918", "species_351597" ] }, "reaction_10447206": { "compartment": "compartment_876", "id": "reaction_10447206", "reactome": "R-DME-400037", "name": "Gi,Go Heterotrimeric G-protein complex dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447204" ], "products": [ "species_10447202", "species_10447196" ], "modifiers": [], "additional_components": [ "species_29438", "species_29438" ] }, "reaction_10447221": { "compartment": "compartment_876", "id": "reaction_10447221", "reactome": "R-DME-400097", "name": "G-beta:G-gamma inhibits Adenylate cyclase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447217", "species_10447202" ], "products": [ "species_10447219" ], "modifiers": [], "additional_components": [] }, "reaction_10446063": { "compartment": "compartment_70101", "id": "reaction_10446063", "reactome": "R-DME-381727", "name": "RAP1A exchanges GDP for GTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10446061" ], "products": [ "species_29420", "species_10444262" ], "modifiers": [ [ "species_10446032", "catalyst" ], [ "species_10446001", "catalyst" ] ], "additional_components": [ "species_29420", "P08645", "FBgn0004636", "P08645", "FBgn0004636", "species_29438", "A1Z6P8", "FBgn0085421", "species_30389", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10446059": { "compartment": "compartment_876", "id": "reaction_10446059", "reactome": "R-DME-381713", "name": "Potassium voltage-gated channels close in reponse to PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446057" ], "products": [ "species_10446057" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "P17970", "FBgn0262593", "P17972", "FBgn0003386", "A8DYR5", "FBgn0085395", "P17970", "FBgn0262593", "P17972", "FBgn0003386", "A8DYR5", "FBgn0085395", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10446027": { "compartment": "compartment_12045", "id": "reaction_10446027", "reactome": "R-DME-381644", "name": "ER calcium channels open in response to activated PKA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446017" ], "products": [ "species_10446025" ], "modifiers": [ [ "species_10434303", "catalyst" ] ], "additional_components": [ "P29993", "FBgn0010051", "P29993", "FBgn0010051", "species_114520", "Q9VA47", "FBgn0039796", "P16911", "FBgn0000274", "P12370", "Pka-C1" ] }, "reaction_10446003": { "compartment": "compartment_876", "id": "reaction_10446003", "reactome": "R-DME-381608", "name": "cAMP activates EPAC2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10445999" ], "products": [ "species_10446001" ], "modifiers": [], "additional_components": [ "FBgn0085421", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10446034": { "compartment": "compartment_876", "id": "reaction_10446034", "reactome": "R-DME-381668", "name": "cAMP activates EPAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30389", "species_10446030" ], "products": [ "species_10446032" ], "modifiers": [], "additional_components": [ "FBgn0085421", "A1Z6P8", "FBgn0085421", "species_30389" ] }, "reaction_10430876": { "compartment": "compartment_70101", "id": "reaction_10430876", "reactome": "R-DME-73567", "name": "UMPS dimer transfers phoshoribosyl group to ORO to form OMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73566", "species_76632" ], "products": [ "species_111294", "species_111629" ], "modifiers": [ [ "species_10430870", "catalyst" ] ], "additional_components": [ "Q01637", "FBgn0003257" ] }, "reaction_10430873": { "compartment": "compartment_70101", "id": "reaction_10430873", "reactome": "R-DME-73564", "name": "UMPS dimer decarboxylates OMP to UMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111629" ], "products": [ "species_109402", "species_113528" ], "modifiers": [ [ "species_10430870", "catalyst" ] ], "additional_components": [ "Q01637", "FBgn0003257" ] }, "reaction_10430902": { "compartment": "compartment_70101", "id": "reaction_10430902", "reactome": "R-DME-73577", "name": "CAD hexamer transforms L-Gln to CAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_111627", "species_113592", "species_29472" ], "products": [ "species_111647", "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10430893", "catalyst" ] ], "additional_components": [ "P05990", "FBgn0003189" ] }, "reaction_10430886": { "compartment": "compartment_70101", "id": "reaction_10430886", "reactome": "R-DME-73569", "name": "DHODH:FMN oxidises (S)-DHO to orotate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_73663", "species_76630" ], "products": [ "species_76632", "species_76633" ], "modifiers": [ [ "species_10430883", "catalyst" ] ], "additional_components": [ "species_76629", "P32748", "FBgn0000447" ] }, "reaction_10430899": { "compartment": "compartment_70101", "id": "reaction_10430899", "reactome": "R-DME-73573", "name": "CAD hexamer transforms CAP to N-carb-L-Asp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111647", "species_29448" ], "products": [ "species_111628", "species_29372" ], "modifiers": [ [ "species_10430893", "catalyst" ] ], "additional_components": [ "P05990", "FBgn0003189" ] }, "reaction_10430896": { "compartment": "compartment_70101", "id": "reaction_10430896", "reactome": "R-DME-73571", "name": "CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_111628", "species_70106" ], "products": [ "species_29356", "species_76630" ], "modifiers": [ [ "species_10430893", "catalyst" ] ], "additional_components": [ "P05990", "FBgn0003189" ] }, "reaction_10490053": { "compartment": "compartment_7660", "id": "reaction_10490053", "reactome": "R-DME-8866601", "name": "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_8866574" ], "products": [ "species_8866608", "species_8866567" ], "modifiers": [ [ "species_10490050", "catalyst" ], [ "species_29892", "catalyst" ] ], "additional_components": [ "Q9VVY4", "FBgn0028380", "species_1562550" ] }, "reaction_10430942": { "compartment": "compartment_70101", "id": "reaction_10430942", "reactome": "R-DME-73591", "name": "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73588" ], "products": [ "species_113528", "species_73590", "species_31633" ], "modifiers": [ [ "species_10430939", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VI04", "FBgn0037513" ] }, "reaction_10430974": { "compartment": "compartment_70101", "id": "reaction_10430974", "reactome": "R-DME-73616", "name": "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83960", "species_29364" ], "products": [ "species_29366", "species_73541" ], "modifiers": [ [ "species_10430919", "catalyst" ] ], "additional_components": [ "species_76629", "Q9W374", "FBgn0086450", "species_113596" ] }, "reaction_10431581": { "compartment": "compartment_70101", "id": "reaction_10431581", "reactome": "R-DME-74376", "name": "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)", "reversible": "true", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29372", "species_500430" ], "products": [ "species_83962", "species_500244" ], "modifiers": [ [ "species_10431576", "catalyst" ] ], "additional_components": [ "CHEBI:16450", "CHEBI:16704", "CHEBI:28542", "species_112016", "Q9VBA0", "FBgn0039464", "Q8T8S2", "FBgn0034800", "Q0E8U4", "FBgn0031489" ] }, "reaction_10433355": { "compartment": "compartment_70101", "id": "reaction_10433355", "reactome": "R-DME-109449", "name": "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_500347" ], "products": [ "species_500346", "species_29372" ], "modifiers": [ [ "species_10433352", "catalyst" ] ], "additional_components": [ "species_1524067", "CHEBI:15918", "species_109366", "species_109382", "species_418075", "CHEBI:15698", "CHEBI:16450", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_29926", "Q9W197", "FBgn0034988" ] }, "reaction_10430922": { "compartment": "compartment_70101", "id": "reaction_10430922", "reactome": "R-DME-73585", "name": "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_83962", "species_29364" ], "products": [ "species_29366", "species_73584" ], "modifiers": [ [ "species_10430919", "catalyst" ] ], "additional_components": [ "species_76629", "Q9W374", "FBgn0086450", "species_113596" ] }, "reaction_10433333": { "compartment": "compartment_984", "id": "reaction_10433333", "reactome": "R-DME-109291", "name": "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_500316" ], "products": [ "species_109277", "species_500318" ], "modifiers": [ [ "species_10433328", "catalyst" ] ], "additional_components": [ "species_418075", "species_1524067", "species_109366", "CHEBI:16704", "CHEBI:17748", "CHEBI:17562", "species_1562550", "Q8SZY4", "FBgn0050104" ] }, "reaction_10430932": { "compartment": "compartment_70101", "id": "reaction_10430932", "reactome": "R-DME-73589", "name": "5,6-dihydrouracil + H2O => beta-ureidopropionate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73584" ], "products": [ "species_73588" ], "modifiers": [ [ "species_10430929", "catalyst" ] ], "additional_components": [ "Q8IPQ2", "FBgn0023023", "species_1562550" ] }, "reaction_10430978": { "compartment": "compartment_70101", "id": "reaction_10430978", "reactome": "R-DME-73620", "name": "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73617" ], "products": [ "species_113528", "species_73619", "species_31633" ], "modifiers": [ [ "species_10430939", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VI04", "FBgn0037513" ] }, "reaction_10430976": { "compartment": "compartment_70101", "id": "reaction_10430976", "reactome": "R-DME-73618", "name": "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_73541" ], "products": [ "species_73617" ], "modifiers": [ [ "species_10430929", "catalyst" ] ], "additional_components": [ "Q8IPQ2", "FBgn0023023", "species_1562550" ] }, "reaction_10488423": { "compartment": "compartment_984", "id": "reaction_10488423", "reactome": "R-DME-8851356", "name": "NTPDase5 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8936165" ], "products": [ "species_8851369", "species_109277" ], "modifiers": [ [ "species_10488420", "catalyst" ] ], "additional_components": [ "species_29370", "species_205687", "species_29420", "species_110094", "species_418075", "species_1524067", "species_5696194", "species_76577", "M9PBV2", "FBgn0024947", "species_29926", "species_74016" ] }, "reaction_10488430": { "compartment": "compartment_984", "id": "reaction_10488430", "reactome": "R-DME-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_8851462" ], "products": [ "species_109277", "species_8851461" ], "modifiers": [ [ "species_10488427", "catalyst" ] ], "additional_components": [ "CHEBI:17808", "species_205687", "species_29420", "species_110094", "species_418075", "species_29602", "species_1524067", "species_5696194", "species_29926", "species_74016", "M9PBV2", "FBgn0024947" ] }, "reaction_10498277": { "compartment": "compartment_17957", "id": "reaction_10498277", "reactome": "R-DME-9650473", "name": "SERPING1 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498275" ], "products": [ "species_10452491" ], "modifiers": [], "additional_components": [ "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930" ] }, "reaction_10472854": { "compartment": "compartment_984", "id": "reaction_10472854", "reactome": "R-DME-5607023", "name": "factor IXa associates with cell membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435383" ], "products": [ "species_10472852" ], "modifiers": [], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458" ] }, "reaction_10498442": { "compartment": "compartment_17957", "id": "reaction_10498442", "reactome": "R-DME-9670673", "name": "FIX is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498440" ], "products": [ "species_10435369" ], "modifiers": [], "additional_components": [ "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459" ] }, "reaction_10478063": { "compartment": "compartment_984", "id": "reaction_10478063", "reactome": "R-DME-5693346", "name": "CECRI deaminates Ade-Rib to Ino", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_83908" ], "products": [ "species_2022135", "species_83921" ], "modifiers": [ [ "species_10478060", "catalyst" ] ], "additional_components": [ "species_1562550", "Q9VVK5", "FBgn0036752" ] }, "reaction_10497731": { "compartment": "compartment_12045", "id": "reaction_10497731", "reactome": "R-DME-9624789", "name": "pro-SFTPB translocates from ER membrane to multivesicle body", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10497729" ], "products": [ "species_10476466" ], "modifiers": [], "additional_components": [ "FBgn0000416", "FBgn0000416" ] }, "reaction_10476537": { "compartment": "compartment_3828046", "id": "reaction_10476537", "reactome": "R-DME-5684864", "name": "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476466", "species_5685882" ], "products": [ "species_10476468", "species_10476470", "species_10476472" ], "modifiers": [ [ "species_10476534", "catalyst" ] ], "additional_components": [ "FBgn0000416", "FBgn0000416", "FBgn0000416", "FBgn0000416", "Q9VLK3", "FBgn0032049", "Q9VKP7", "FBgn0032303", "Q9VKP6", "FBgn0032304", "Q9VEK4", "FBgn0038506", "Q9W5G3", "FBgn0011822", "Q9VEK3", "FBgn0038507", "Q9VQ14", "FBgn0053128", "Q7K485", "FBgn0029093", "Q9VQ13", "FBgn0051926", "A1Z9Q9", "FBgn0033933", "Q9VQ12", "FBgn0053128", "Q9VQ11", "FBgn0051928", "Q9VNK6", "FBgn0037396" ] }, "reaction_10480360": { "compartment": "compartment_3828046", "id": "reaction_10480360", "reactome": "R-DME-6791016", "name": "SFTPB binds itself", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476468" ], "products": [ "species_10476539" ], "modifiers": [], "additional_components": [ "FBgn0000416", "Q9Y125", "FBgn0000416" ] }, "reaction_10476405": { "compartment": "compartment_7660", "id": "reaction_10476405", "reactome": "R-DME-5683888", "name": "LMCD1 binds GATA6, sequestering it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10476401", "species_10457526" ], "products": [ "species_10476403" ], "modifiers": [], "additional_components": [ "FBgn0034223", "Q9VF00", "FBgn0038391", "P52168", "FBgn0003117", "Q9VF00", "FBgn0038391", "P52168", "FBgn0003117", "A1ZAT5", "FBgn0034223" ] }, "reaction_10498522": { "compartment": "compartment_7660", "id": "reaction_10498522", "reactome": "R-DME-9679787", "name": "HDAC1:2-containing complex binds HDAC2 Inhibitors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10498518", "species_9679795" ], "products": [ "species_10498520" ], "modifiers": [], "additional_components": [ "Q9VXB3", "FBgn0030788", "Q94517", "HDAC1", "Q9VWP5", "FBgn0085451", "Q9VWG2", "FBgn0031036", "Q9VEX9", "FBgn0024491", "Q24572", "FBgn0263979", "Q9VYI2", "FBgn0030434", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397", "Q9VK36", "FBgn0032473", "Q8T092", "FBgn0034114", "Q9VRV0", "FBgn0035687", "Q9VH18", "FBgn0037794", "Q9W137", "FBgn0035036", "Q9VIS9", "FBgn0032814", "A1ZBC5", "FBgn0034379", "O97159", "FBgn0262519", "O16102", "FBgn0023395", "Q9VXB3", "FBgn0030788", "Q94517", "HDAC1", "Q9VWP5", "FBgn0085451", "Q9VWG2", "FBgn0031036", "Q9VEX9", "FBgn0024491", "Q24572", "FBgn0263979", "Q9VYI2", "FBgn0030434", "Q9W2K8", "FBgn0026582", "Q59E36", "FBgn0261573", "Q8IPD6", "FBgn0051875", "Q9VW97", "FBgn0260397", "Q9VK36", "FBgn0032473", "Q8T092", "FBgn0034114", "Q9VRV0", "FBgn0035687", "Q9VH18", "FBgn0037794", "Q9W137", "FBgn0035036", "Q9VIS9", "FBgn0032814", "A1ZBC5", "FBgn0034379", "O97159", "FBgn0262519", "O16102", "FBgn0023395" ] }, "reaction_10461614": { "compartment": "compartment_7660", "id": "reaction_10461614", "reactome": "R-DME-1855181", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023922" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461741": { "compartment": "compartment_7660", "id": "reaction_10461741", "reactome": "R-DME-1855230", "name": "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023922" ], "products": [ "species_113582", "species_2023948" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461580": { "compartment": "compartment_7660", "id": "reaction_10461580", "reactome": "R-DME-1855176", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023901" ], "products": [ "species_113582", "species_2023929" ], "modifiers": [ [ "species_10461577", "catalyst" ] ], "additional_components": [ "FBgn0050295" ] }, "reaction_10461738": { "compartment": "compartment_7660", "id": "reaction_10461738", "reactome": "R-DME-1855228", "name": "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023892" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461658": { "compartment": "compartment_7660", "id": "reaction_10461658", "reactome": "R-DME-1855207", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023929" ], "products": [ "species_113582", "species_2023940" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461529": { "compartment": "compartment_7660", "id": "reaction_10461529", "reactome": "R-DME-1855157", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023932" ], "products": [ "species_113582", "species_2023931" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461655": { "compartment": "compartment_7660", "id": "reaction_10461655", "reactome": "R-DME-1855206", "name": "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023891" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461747": { "compartment": "compartment_7660", "id": "reaction_10461747", "reactome": "R-DME-1855233", "name": "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023907" ], "products": [ "species_113582", "species_2023891" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461729": { "compartment": "compartment_7660", "id": "reaction_10461729", "reactome": "R-DME-1855224", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023940" ], "products": [ "species_113582", "species_2023941" ], "modifiers": [ [ "species_10461524", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461632": { "compartment": "compartment_7660", "id": "reaction_10461632", "reactome": "R-DME-1855185", "name": "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_2023935" ], "products": [ "species_113582", "species_2023901" ], "modifiers": [ [ "species_10461629", "catalyst" ] ], "additional_components": [ "FBgn0031267" ] }, "reaction_10461567": { "compartment": "compartment_70101", "id": "reaction_10461567", "reactome": "R-DME-1855166", "name": "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023943" ], "products": [ "species_29372", "species_994141" ], "modifiers": [ [ "species_10461555", "catalyst" ] ], "additional_components": [ "species_1629736", "species_2023922", "CHEBI:62927", "species_29926", "species_266099", "Q7JVG2", "FBgn0036111" ] }, "reaction_10461726": { "compartment": "compartment_70101", "id": "reaction_10461726", "reactome": "R-DME-1855223", "name": "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629755" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461564": { "compartment": "compartment_70101", "id": "reaction_10461564", "reactome": "R-DME-1855165", "name": "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_1629765", "species_29372" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "species_2023931", "CHEBI:62924", "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10461624": { "compartment": "compartment_70101", "id": "reaction_10461624", "reactome": "R-DME-1855182", "name": "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10461619", "catalyst" ] ], "additional_components": [ "FBgn0027279" ] }, "reaction_10463703": { "compartment": "compartment_70101", "id": "reaction_10463703", "reactome": "R-DME-2023973", "name": "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2023968", "species_29356" ], "products": [ "species_29372", "species_2023974" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "species_2023931", "CHEBI:62924", "species_2023932", "CHEBI:62922", "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10463701": { "compartment": "compartment_70101", "id": "reaction_10463701", "reactome": "R-DME-2023971", "name": "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2023974" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "species_2023932", "CHEBI:62922", "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10461641": { "compartment": "compartment_70101", "id": "reaction_10461641", "reactome": "R-DME-1855198", "name": "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_29356" ], "products": [ "species_29372", "species_1629770" ], "modifiers": [ [ "species_10461561", "catalyst" ] ], "additional_components": [ "Q7JVG2", "FBgn0036111", "species_29926", "species_266099" ] }, "reaction_10461608": { "compartment": "compartment_70101", "id": "reaction_10461608", "reactome": "R-DME-1855179", "name": "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_994141" ], "products": [ "species_29370", "species_1629770" ], "modifiers": [ [ "species_10461605", "catalyst" ] ], "additional_components": [ "FBgn0050295" ] }, "reaction_10461735": { "compartment": "compartment_70101", "id": "reaction_10461735", "reactome": "R-DME-1855227", "name": "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_1629765", "species_29370" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461638": { "compartment": "compartment_70101", "id": "reaction_10461638", "reactome": "R-DME-1855194", "name": "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629740" ], "products": [ "species_1629732", "species_29370" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461701": { "compartment": "compartment_70101", "id": "reaction_10461701", "reactome": "R-DME-1855216", "name": "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629770" ], "products": [ "species_29370", "species_1629740" ], "modifiers": [ [ "species_10461619", "catalyst" ] ], "additional_components": [ "FBgn0027279" ] }, "reaction_10461635": { "compartment": "compartment_70101", "id": "reaction_10461635", "reactome": "R-DME-1855193", "name": "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_1629736" ], "products": [ "species_29370", "species_1629738" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10461536": { "compartment": "compartment_70101", "id": "reaction_10461536", "reactome": "R-DME-1855158", "name": "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1629765", "species_113592" ], "products": [ "species_29370", "species_1629759" ], "modifiers": [ [ "species_10461531", "catalyst" ] ], "additional_components": [ "FBgn0034644" ] }, "reaction_10442750": { "compartment": "compartment_70616", "id": "reaction_10442750", "reactome": "R-DME-209765", "name": "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_209800", "species_29368", "species_29364" ], "products": [ "species_29356", "species_350159", "species_29366" ], "modifiers": [ [ "species_10442747", "catalyst" ], [ "species_29532", "catalyst" ] ], "additional_components": [ "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033", "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053" ] }, "reaction_10495353": { "compartment": "compartment_161320", "id": "reaction_10495353", "reactome": "R-DME-8963864", "name": "CUBN dissociates from 25(OH)D", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495351" ], "products": [ "species_350136", "species_10495349" ], "modifiers": [], "additional_components": [ "A8JQY3", "FBgn0085431", "species_8963879", "FBgn0085431" ] }, "reaction_10495357": { "compartment": "compartment_7660", "id": "reaction_10495357", "reactome": "R-DME-8963915", "name": "1,25(OH)2D binds VDR", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445234", "species_8963912" ], "products": [ "species_10495355" ], "modifiers": [], "additional_components": [ "FBgn0015240", "species_8963912", "Q24143", "FBgn0015240" ] }, "reaction_10460847": { "compartment": "compartment_70101", "id": "reaction_10460847", "reactome": "R-DME-1655831", "name": "SREBP1A,1C,2 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460835" ], "products": [ "species_10460845" ], "modifiers": [], "additional_components": [ "O18388", "FBgn0262743", "Q9VW37", "FBgn0261283", "Q9VW37", "FBgn0261283", "O18388", "FBgn0262743" ] }, "reaction_10464750": { "compartment": "compartment_70101", "id": "reaction_10464750", "reactome": "R-DME-2065549", "name": "SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460827" ], "products": [ "species_10460833" ], "modifiers": [], "additional_components": [ "FBgn0261283", "Q9VW37", "FBgn0261283" ] }, "reaction_10464748": { "compartment": "compartment_7660", "id": "reaction_10464748", "reactome": "R-DME-2065539", "name": "SREBP1A,1C,2:Importin beta-1 dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442310", "species_10460845" ], "products": [ "species_10464746", "species_10460843" ], "modifiers": [], "additional_components": [ "species_29438", "Q9VZ23", "FBgn0020255", "Q9VW37", "FBgn0261283", "O18388", "FBgn0262743", "O18388", "FBgn0262743", "species_29438", "Q9VZ23", "FBgn0020255", "Q9VW37", "FBgn0261283" ] }, "reaction_10460870": { "compartment": "compartment_20699", "id": "reaction_10460870", "reactome": "R-DME-1655851", "name": "S2P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460862" ], "products": [ "species_10460827" ], "modifiers": [ [ "species_10447716", "catalyst" ] ], "additional_components": [ "FBgn0261283", "FBgn0261283", "FBgn0033656" ] }, "reaction_10460868": { "compartment": "compartment_20699", "id": "reaction_10460868", "reactome": "R-DME-1655842", "name": "S1P hydrolyzes SREBP1A,1C,2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460860" ], "products": [ "species_10460858", "species_10460862" ], "modifiers": [ [ "species_10445971", "catalyst" ] ], "additional_components": [ "A1Z6J2", "FBgn0033052", "Q9VW37", "FBgn0261283", "A1Z6J2", "FBgn0033052", "FBgn0261283", "FBgn0037105" ] }, "reaction_10464752": { "compartment": "compartment_70101", "id": "reaction_10464752", "reactome": "R-DME-2065550", "name": "SREBP1A,1C,2 binds Importin beta-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10460833", "species_10443115" ], "products": [ "species_10460835" ], "modifiers": [], "additional_components": [ "Q9VW37", "FBgn0261283", "FBgn0262743", "O18388", "FBgn0262743", "Q9VW37", "FBgn0261283" ] }, "reaction_10446655": { "compartment": "compartment_17951", "id": "reaction_10446655", "reactome": "R-DME-390425", "name": "FAR1 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10446652", "catalyst" ] ], "additional_components": [ "FBgn0039131" ] }, "reaction_10487936": { "compartment": "compartment_12045", "id": "reaction_10487936", "reactome": "R-DME-8848582", "name": "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848577", "species_200993" ], "products": [ "species_8848499", "species_76194" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10446670": { "compartment": "compartment_17951", "id": "reaction_10446670", "reactome": "R-DME-390438", "name": "FAR2 reduces PalmCoA to HXOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29364", "species_200993" ], "products": [ "species_29366", "species_8848577", "species_76194" ], "modifiers": [ [ "species_10446667", "catalyst" ] ], "additional_components": [ "Q9VES6", "FBgn0038450", "Q9VES5", "FBgn0038451" ] }, "reaction_10487938": { "compartment": "compartment_12045", "id": "reaction_10487938", "reactome": "R-DME-8848585", "name": "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_200993", "species_30209" ], "products": [ "species_76194", "species_2534407" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10479146": { "compartment": "compartment_12045", "id": "reaction_10479146", "reactome": "R-DME-5696424", "name": "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192172", "species_5696426" ], "products": [ "species_5696412", "species_162743" ], "modifiers": [ [ "species_10479143", "catalyst" ] ], "additional_components": [ "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10489409": { "compartment": "compartment_12045", "id": "reaction_10489409", "reactome": "R-DME-8857686", "name": "FITM1, FITM2 bind TAGs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10489403", "species_549167" ], "products": [ "species_10489407" ], "modifiers": [], "additional_components": [ "FBgn0035586", "species_1500594", "Q9VRJ2", "FBgn0035586" ] }, "reaction_10489306": { "compartment": "compartment_13977", "id": "reaction_10489306", "reactome": "R-DME-8856630", "name": "CIDEA:CIDEC binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866926", "species_10489302" ], "products": [ "species_10489304" ], "modifiers": [], "additional_components": [ "species_1500594", "species_163579", "CHEBI:16247", "A8DY77", "FBgn0028408", "Q0E9B7", "FBgn0028407", "A8DY77", "FBgn0028408", "Q0E9B7", "FBgn0028407", "species_1500594", "species_163579", "CHEBI:16247" ] }, "reaction_10489517": { "compartment": "compartment_70101", "id": "reaction_10489517", "reactome": "R-DME-8862380", "name": "HSD17B13 binds lipid droplets", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8866926", "species_10478095" ], "products": [ "species_10489515" ], "modifiers": [], "additional_components": [ "species_1500594", "species_163579", "CHEBI:16247", "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043", "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043", "species_1500594", "species_163579", "CHEBI:16247" ] }, "reaction_10465087": { "compartment": "compartment_12045", "id": "reaction_10465087", "reactome": "R-DME-2161745", "name": "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2161636" ], "products": [ "species_29356", "species_29366", "species_2142740" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10465100": { "compartment": "compartment_12045", "id": "reaction_10465100", "reactome": "R-DME-2161792", "name": "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29364", "species_2142740" ], "products": [ "species_2161582", "species_29356", "species_29366" ], "modifiers": [ [ "species_10443160", "catalyst" ] ], "additional_components": [ "O46054", "FBgn0015036", "Q9VS78", "FBgn0035790", "O46051", "FBgn0023541", "Q9VMS9", "FBgn0031693", "Q9VMS8", "FBgn0031694", "Q9VMS7", "FBgn0031695", "Q9VLZ7", "FBgn0031925", "Q9VL92", "FBgn0015035", "Q9VGH1", "FBgn0003312", "Q9V7G5", "FBgn0034053", "Q9V559", "FBgn0033397", "Q9V558", "FBgn0015037", "Q9V557", "FBgn0033395", "Q9V4T5", "FBgn0015034", "Q9W011", "FBgn0035344", "Q9V4T3", "FBgn0033292", "Q9VYQ7", "FBgn0030367", "Q27606", "FBgn0014469", "Q9VXY0", "FBgn0030615", "Q27589", "FBgn0011576", "Q9VVN6", "FBgn0036778", "P33269", "FBgn0005670", "Q9VS79", "FBgn0015033" ] }, "reaction_10443833": { "compartment": "compartment_876", "id": "reaction_10443833", "reactome": "R-DME-266070", "name": "LTC4 is exported from the cytosol by ABCC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266066" ], "products": [ "species_266013" ], "modifiers": [ [ "species_10443830", "catalyst" ] ], "additional_components": [ "FBgn0032456" ] }, "reaction_10443764": { "compartment": "compartment_876", "id": "reaction_10443764", "reactome": "R-DME-266012", "name": "LTD4 is converted to LTE4 by DPEP1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_266074", "species_109276" ], "products": [ "species_266029", "species_266033" ], "modifiers": [ [ "species_10443761", "catalyst" ] ], "additional_components": [ "Q9VBG1", "FBgn0039420", "X2JCU8", "FBgn0266100", "Q9VPG0", "FBgn0036986", "Q9VJ94", "FBgn0261804", "species_1562550" ] }, "reaction_10443843": { "compartment": "compartment_70101", "id": "reaction_10443843", "reactome": "R-DME-266072", "name": "LTA4 is hydolysed to LTB4 by LTA4H", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_265281" ], "products": [ "species_266056" ], "modifiers": [ [ "species_10443840", "catalyst" ] ], "additional_components": [ "Q9VJ39", "FBgn0032721", "species_1562550" ] }, "reaction_10443825": { "compartment": "compartment_876", "id": "reaction_10443825", "reactome": "R-DME-266046", "name": "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_266013" ], "products": [ "species_266074", "species_210382" ], "modifiers": [ [ "species_10443822", "catalyst" ] ], "additional_components": [ "Q9VYR2", "FBgn0030361", "Q9VWT3", "FBgn0030932", "Q7KUX2", "FBgn0030796", "M9NFP5", "FBgn0025837" ] }, "reaction_10465110": { "compartment": "compartment_12045", "id": "reaction_10465110", "reactome": "R-DME-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_2161753", "species_29366" ], "modifiers": [ [ "species_10432779", "catalyst" ] ], "additional_components": [ "CHEBI:34130", "CHEBI:34490", "CHEBI:34157", "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10465108": { "compartment": "compartment_12045", "id": "reaction_10465108", "reactome": "R-DME-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_29768", "species_29364" ], "products": [ "species_29356", "species_29366", "species_2142739" ], "modifiers": [ [ "species_10432779", "catalyst" ] ], "additional_components": [ "Q9VWR5", "FBgn0004959", "Q95078", "FBgn0010383" ] }, "reaction_10465126": { "compartment": "compartment_70101", "id": "reaction_10465126", "reactome": "R-DME-2161999", "name": "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2142811", "species_29450" ], "products": [ "species_29356", "species_2142678", "species_111745" ], "modifiers": [ [ "species_10465121", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10465124": { "compartment": "compartment_70101", "id": "reaction_10465124", "reactome": "R-DME-2161959", "name": "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_2142790" ], "products": [ "species_29356", "species_2142716", "species_111745" ], "modifiers": [ [ "species_10465121", "catalyst" ] ], "additional_components": [ "FBgn0035438" ] }, "reaction_10478161": { "compartment": "compartment_13977", "id": "reaction_10478161", "reactome": "R-DME-5693751", "name": "FAAH2 hydrolyses AEA to AA and ETA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5693752", "species_5693747" ], "products": [ "species_5693736", "species_5693733" ], "modifiers": [ [ "species_10478158", "catalyst" ] ], "additional_components": [ "FBgn0033717" ] }, "reaction_10464589": { "compartment": "compartment_17957", "id": "reaction_10464589", "reactome": "R-DME-2046088", "name": "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046066", "species_2046052", "species_113601" ], "products": [ "species_113519", "species_113564", "species_2046051", "species_162743", "species_159751" ], "modifiers": [ [ "species_10453288", "catalyst" ] ], "additional_components": [ "Q9VV87", "FBgn0260960", "Q9VHX7", "FBgn0037534", "Q6NN18", "FBgn0034382", "Q9VCY6", "FBgn0038986", "Q9VH59", "FBgn0037761", "Q4V3H4", "FBgn0037764", "Q9VCY5", "FBgn0053110", "Q9VH58", "FBgn0037762", "A1ZBD2", "FBgn0034383", "Q9VCT3", "FBgn0039030", "Q9VH57", "FBgn0037763", "Q95T98", "FBgn0051523", "Q9VH55", "FBgn0037765", "Q8SXD1", "FBgn0050008", "Q9VCZ0", "FBgn0038983", "Q8IMY2", "FBgn0051141", "Q9VCY7", "FBgn0260942" ] }, "reaction_10464587": { "compartment": "compartment_17957", "id": "reaction_10464587", "reactome": "R-DME-2046087", "name": "Translocation of tetracosahexaenoyl-CoA to peroxisomes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2046054", "species_211579" ], "products": [ "species_426639", "species_211606", "species_2046047" ], "modifiers": [ [ "species_10446277", "catalyst" ] ], "additional_components": [ "FBgn0039890" ] }, "reaction_10464779": { "compartment": "compartment_17951", "id": "reaction_10464779", "reactome": "R-DME-2066787", "name": "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_2046047" ], "products": [ "species_113575", "species_2066767" ], "modifiers": [ [ "species_10446616", "catalyst" ] ], "additional_components": [ "species_113596", "Q7KML2", "FBgn0027572" ] }, "reaction_10464777": { "compartment": "compartment_17951", "id": "reaction_10464777", "reactome": "R-DME-2066780", "name": "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2066766" ], "products": [ "species_2066762" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10464775": { "compartment": "compartment_17951", "id": "reaction_10464775", "reactome": "R-DME-2066778", "name": "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_2066767" ], "products": [ "species_2066766" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10491976": { "compartment": "compartment_70616", "id": "reaction_10491976", "reactome": "R-DME-8933547", "name": "MCAT transfers Mal from Mal-CoA to NDUFAB1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491965", "species_977314" ], "products": [ "species_29374", "species_10491968" ], "modifiers": [ [ "species_10491973", "catalyst" ] ], "additional_components": [ "FBgn0011361", "FBgn0011361", "FBgn0036691" ] }, "reaction_10487865": { "compartment": "compartment_17957", "id": "reaction_10487865", "reactome": "R-DME-8848246", "name": "DBI, ACBD7 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848288", "species_10487859" ], "products": [ "species_10487863" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "FBgn0031992", "Q9VLS4", "FBgn0031992", "species_164991", "species_5690542" ] }, "reaction_10477557": { "compartment": "compartment_5460", "id": "reaction_10477557", "reactome": "R-DME-5690066", "name": "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690540", "species_113521" ], "products": [ "species_29374", "species_5690519" ], "modifiers": [ [ "species_10477554", "catalyst" ] ], "additional_components": [ "species_164991", "species_5690542", "species_30495", "species_5690531", "FBgn0039854" ] }, "reaction_10477541": { "compartment": "compartment_70101", "id": "reaction_10477541", "reactome": "R-DME-5690043", "name": "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5690044" ], "products": [ "species_5690064", "species_76194" ], "modifiers": [ [ "species_10477538", "catalyst" ] ], "additional_components": [ "species_5690542", "species_164991", "species_5690531", "species_30495", "Q9VZZ6", "FBgn0035355", "Q9VZZ5", "FBgn0035356" ] }, "reaction_10491084": { "compartment": "compartment_5460", "id": "reaction_10491084", "reactome": "R-DME-8874745", "name": "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113559", "species_1524038" ], "products": [ "species_29374", "species_8874749" ], "modifiers": [ [ "species_10491081", "catalyst" ] ], "additional_components": [ "Q9VL70", "FBgn0040064" ] }, "reaction_10479074": { "compartment": "compartment_5460", "id": "reaction_10479074", "reactome": "R-DME-5696004", "name": "ACSF2 ligates CoA-SH to MCFA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29374", "species_113593", "species_5690531" ], "products": [ "species_159448", "species_159450", "species_5690542" ], "modifiers": [ [ "species_10479071", "catalyst" ] ], "additional_components": [ "FBgn0031703" ] }, "reaction_10487885": { "compartment": "compartment_70101", "id": "reaction_10487885", "reactome": "R-DME-8848250", "name": "ACBD6 binds LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_164991", "species_10487881" ], "products": [ "species_10487883" ], "modifiers": [], "additional_components": [ "FBgn0064116", "Q9VRG6", "FBgn0064116", "species_164991" ] }, "reaction_10479965": { "compartment": "compartment_17951", "id": "reaction_10479965", "reactome": "R-DME-6787811", "name": "HAO2 tetramer oxidises 2OH-PALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_6787810" ], "products": [ "species_113575", "species_6787814" ], "modifiers": [ [ "species_10479962", "catalyst" ] ], "additional_components": [ "A1Z8D3", "FBgn0061356" ] }, "reaction_10486915": { "compartment": "compartment_17951", "id": "reaction_10486915", "reactome": "R-DME-6810474", "name": "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_6810523" ], "products": [ "species_6809360", "species_6810530" ], "modifiers": [ [ "species_10486912", "catalyst" ] ], "additional_components": [ "FBgn0032790" ] }, "reaction_10487876": { "compartment": "compartment_17947", "id": "reaction_10487876", "reactome": "R-DME-8848247", "name": "ACBD4,5 bind MCFA-CoA and LCFA-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5690520", "species_10487870" ], "products": [ "species_10487874" ], "modifiers": [], "additional_components": [ "species_164991", "species_5690542", "FBgn0031478", "species_164991", "species_5690542", "Q9VQI6", "FBgn0031478" ] }, "reaction_10446606": { "compartment": "compartment_17951", "id": "reaction_10446606", "reactome": "R-DME-389995", "name": "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389982", "species_192307" ], "products": [ "species_193465", "species_389996", "species_192305" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446589": { "compartment": "compartment_17951", "id": "reaction_10446589", "reactome": "R-DME-389889", "name": "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10440153", "catalyst" ] ], "additional_components": [ "species_113596", "Q9W2G8", "FBgn0034629", "Q7KML2", "FBgn0027572", "Q9W3U0", "FBgn0029924", "Q9W2G9", "FBgn0034628" ] }, "reaction_10446637": { "compartment": "compartment_17951", "id": "reaction_10446637", "reactome": "R-DME-390291", "name": "acetyl-CoA + carnitine => acetylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_353123", "species_390294" ], "products": [ "species_390287", "species_193514" ], "modifiers": [ [ "species_10446632", "catalyst" ] ], "additional_components": [ "FBgn0038486" ] }, "reaction_10446604": { "compartment": "compartment_17951", "id": "reaction_10446604", "reactome": "R-DME-389986", "name": "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_389894" ], "products": [ "species_389982" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446635": { "compartment": "compartment_17951", "id": "reaction_10446635", "reactome": "R-DME-390284", "name": "propionyl-CoA + carnitine => propionylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_192314", "species_390294" ], "products": [ "species_193514", "species_390274" ], "modifiers": [ [ "species_10446632", "catalyst" ] ], "additional_components": [ "FBgn0038486" ] }, "reaction_10446601": { "compartment": "compartment_17951", "id": "reaction_10446601", "reactome": "R-DME-389897", "name": "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389569" ], "products": [ "species_389893" ], "modifiers": [ [ "species_10440102", "catalyst" ] ], "additional_components": [ "FBgn0032881" ] }, "reaction_10446599": { "compartment": "compartment_17951", "id": "reaction_10446599", "reactome": "R-DME-389891", "name": "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_389893" ], "products": [ "species_113575", "species_389894" ], "modifiers": [ [ "species_10446596", "catalyst" ] ], "additional_components": [ "species_113596", "B7Z028", "FBgn0031813" ] }, "reaction_10446627": { "compartment": "compartment_17951", "id": "reaction_10446627", "reactome": "R-DME-390281", "name": "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390271", "species_390294" ], "products": [ "species_193514", "species_390290" ], "modifiers": [ [ "species_10446624", "catalyst" ] ], "additional_components": [ "FBgn0039543" ] }, "reaction_10446619": { "compartment": "compartment_17951", "id": "reaction_10446619", "reactome": "R-DME-390256", "name": "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113535", "species_390260" ], "products": [ "species_390249", "species_113575" ], "modifiers": [ [ "species_10446616", "catalyst" ] ], "additional_components": [ "species_113596", "Q7KML2", "FBgn0027572" ] }, "reaction_10446647": { "compartment": "compartment_17947", "id": "reaction_10446647", "reactome": "R-DME-390393", "name": "Peroxisomal uptake of very long-chain fatty acyl CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390394" ], "products": [ "species_390260" ], "modifiers": [ [ "species_10446279", "catalyst" ] ], "additional_components": [ "Q7JUN3", "FBgn0039890" ] }, "reaction_10446610": { "compartment": "compartment_17951", "id": "reaction_10446610", "reactome": "R-DME-390252", "name": "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_141343", "species_390249" ], "products": [ "species_390248" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446608": { "compartment": "compartment_17951", "id": "reaction_10446608", "reactome": "R-DME-390251", "name": "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_390248", "species_192307" ], "products": [ "species_193465", "species_390241", "species_192305" ], "modifiers": [ [ "species_10440126", "catalyst" ] ], "additional_components": [ "Q9VXJ0", "FBgn0030731" ] }, "reaction_10446474": { "compartment": "compartment_17951", "id": "reaction_10446474", "reactome": "R-DME-389611", "name": "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389594" ], "products": [ "species_389578", "species_389636" ], "modifiers": [ [ "species_10446471", "catalyst" ] ], "additional_components": [ "species_8878387", "species_29926", "Q7K3B7", "FBgn0034488" ] }, "reaction_10446488": { "compartment": "compartment_17951", "id": "reaction_10446488", "reactome": "R-DME-389632", "name": "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6811612", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389569", "species_389620" ], "modifiers": [ [ "species_10446482", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10446485": { "compartment": "compartment_17951", "id": "reaction_10446485", "reactome": "R-DME-389622", "name": "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_389596", "species_193514", "species_389573" ], "products": [ "species_389593", "species_389615", "species_389620" ], "modifiers": [ [ "species_10446482", "catalyst" ] ], "additional_components": [ "Q7KVJ6", "FBgn0265187", "E1JHE4", "FBgn0267828", "Q8SXR7", "FBgn0034999" ] }, "reaction_10446496": { "compartment": "compartment_17947", "id": "reaction_10446496", "reactome": "R-DME-389652", "name": "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_389620" ], "products": [ "species_389573", "species_76577" ], "modifiers": [ [ "species_10446493", "catalyst" ] ], "additional_components": [ "FBgn0052250" ] }, "reaction_10484754": { "compartment": "compartment_70101", "id": "reaction_10484754", "reactome": "R-DME-6800149", "name": "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6806829", "species_71284" ], "products": [ "species_6800127", "species_71285" ], "modifiers": [ [ "species_10484748", "catalyst" ] ], "additional_components": [ "Q9VP65", "FBgn0037061", "Q9VQF8", "FBgn0031454" ] }, "reaction_10479105": { "compartment": "compartment_70101", "id": "reaction_10479105", "reactome": "R-DME-5696230", "name": "GSTO1 dimer reduces methylarsonate to methylarsonite", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_5696214" ], "products": [ "species_29356", "species_5696224", "species_111745" ], "modifiers": [ [ "species_10438462", "catalyst" ] ], "additional_components": [ "Q9VSL3", "FBgn0086348" ] }, "reaction_10438713": { "compartment": "compartment_70101", "id": "reaction_10438713", "reactome": "R-DME-176631", "name": "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176626" ], "products": [ "species_176496", "species_158466" ], "modifiers": [ [ "species_10438710", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438678": { "compartment": "compartment_70101", "id": "reaction_10438678", "reactome": "R-DME-176521", "name": "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176619", "species_158471" ], "products": [ "species_176492", "species_158466" ], "modifiers": [ [ "species_10438632", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438708": { "compartment": "compartment_70101", "id": "reaction_10438708", "reactome": "R-DME-176609", "name": "cholesterol + PAPS => cholesterol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176478", "species_158471" ], "products": [ "species_176618", "species_158466" ], "modifiers": [ [ "species_10438667", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438675": { "compartment": "compartment_70101", "id": "reaction_10438675", "reactome": "R-DME-176517", "name": "SULTs transfer (SO4)2- group to PREG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193103", "species_158471" ], "products": [ "species_176665", "species_158466" ], "modifiers": [ [ "species_10438672", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438738": { "compartment": "compartment_70101", "id": "reaction_10438738", "reactome": "R-DME-176669", "name": "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176566" ], "products": [ "species_176500", "species_158466" ], "modifiers": [ [ "species_10438735", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438706": { "compartment": "compartment_70101", "id": "reaction_10438706", "reactome": "R-DME-176606", "name": "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_158466" ], "products": [ "species_29372", "species_76577" ], "modifiers": [ [ "species_10438703", "catalyst" ] ], "additional_components": [ "FBgn0039698" ] }, "reaction_10435664": { "compartment": "compartment_70101", "id": "reaction_10435664", "reactome": "R-DME-158860", "name": "SULT1A1 dimer sulfonates NHABP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158847", "species_158471" ], "products": [ "species_158859", "species_158466" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10435662": { "compartment": "compartment_70101", "id": "reaction_10435662", "reactome": "R-DME-158849", "name": "Phenol can form a sulfate conjugate", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158858", "species_158471" ], "products": [ "species_158466", "species_158850" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438670": { "compartment": "compartment_70101", "id": "reaction_10438670", "reactome": "R-DME-176494", "name": "SULTs transfer (SO4)2- group to 27HCHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176617", "species_158471" ], "products": [ "species_176502", "species_158466" ], "modifiers": [ [ "species_10438667", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438733": { "compartment": "compartment_70101", "id": "reaction_10438733", "reactome": "R-DME-176664", "name": "estrone + PAPS => estrone 3-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176575", "species_158471" ], "products": [ "species_176501", "species_158466" ], "modifiers": [ [ "species_10438730", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10494994": { "compartment": "compartment_17963", "id": "reaction_10494994", "reactome": "R-DME-8953499", "name": "IMPAD1 hydrolyses PAP to AMP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_742343", "species_2022884" ], "products": [ "species_8851226", "species_8953493" ], "modifiers": [ [ "species_10494991", "catalyst" ], [ "species_8953505", "inhibitor" ] ], "additional_components": [ "species_29926", "Q9VYF2", "FBgn0030465" ] }, "reaction_10438698": { "compartment": "compartment_70101", "id": "reaction_10438698", "reactome": "R-DME-176604", "name": "taurolithocholate + PAPS => taurolithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176565", "species_158471" ], "products": [ "species_176483", "species_158466" ], "modifiers": [ [ "species_10438642", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438728": { "compartment": "compartment_70101", "id": "reaction_10438728", "reactome": "R-DME-176646", "name": "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5695950", "species_158471" ], "products": [ "species_176600", "species_158466" ], "modifiers": [ [ "species_10438725", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438696": { "compartment": "compartment_70101", "id": "reaction_10438696", "reactome": "R-DME-176588", "name": "lithocholate + PAPS => lithocholate sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176655", "species_158471" ], "products": [ "species_176555", "species_158466" ], "modifiers": [ [ "species_10438642", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438693": { "compartment": "compartment_70101", "id": "reaction_10438693", "reactome": "R-DME-176585", "name": "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_176667", "species_158471" ], "products": [ "species_176564", "species_158466" ], "modifiers": [ [ "species_10438690", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10435652": { "compartment": "compartment_70101", "id": "reaction_10435652", "reactome": "R-DME-158468", "name": "SULT1A1 dimer sulfonates PARA to PARA-SO4", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158469", "species_158471" ], "products": [ "species_158472", "species_158466" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10435745": { "compartment": "compartment_70101", "id": "reaction_10435745", "reactome": "R-DME-159358", "name": "SULT1A3,4 dimers sulfate DA to DAOS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_159362" ], "products": [ "species_159352", "species_158466" ], "modifiers": [ [ "species_10435649", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438657": { "compartment": "compartment_70101", "id": "reaction_10438657", "reactome": "R-DME-176474", "name": "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158471", "species_176486" ], "products": [ "species_176519", "species_158466" ], "modifiers": [ [ "species_10438654", "catalyst" ] ], "additional_components": [ "Q9W1L8", "FBgn0034887", "Q9VHH0", "FBgn0037665", "A1Z9J8", "FBgn0033887" ] }, "reaction_10438525": { "compartment": "compartment_70101", "id": "reaction_10438525", "reactome": "R-DME-176054", "name": "GST dimers conjugate GSH with cytosolic substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450", "species_176070" ], "products": [ "species_176049" ], "modifiers": [ [ "species_10438522", "catalyst" ] ], "additional_components": [ "CHEBI:29132", "CHEBI:34718", "CHEBI:30614", "CHEBI:8927", "CHEBI:32639", "CHEBI:34479", "A1Z7X7", "FBgn0050005", "Q8MRM0", "FBgn0030484", "Q7K0B6", "FBgn0050000", "E1JJS1", "FBgn0031117", "Q9VSL3", "FBgn0086348", "P41043", "FBgn0010226", "Q9VSL6", "FBgn0035907", "Q9VSL5", "FBgn0035906", "Q9VSL2", "FBgn0035904", "Q9VHD2", "FBgn0037697" ] }, "reaction_10438399": { "compartment": "compartment_70101", "id": "reaction_10438399", "reactome": "R-DME-174367", "name": "GCL ligates L-Glu to L-Cys", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_111707", "species_113592" ], "products": [ "species_29372", "species_174393", "species_29370" ], "modifiers": [ [ "species_10438396", "catalyst" ] ], "additional_components": [ "Q9VCW6", "FBgn0046114", "Q9W3K5", "FBgn0040319" ] }, "reaction_10458317": { "compartment": "compartment_70101", "id": "reaction_10458317", "reactome": "R-DME-1247935", "name": "OPLAH hydrolyses OPRO to L-Glu", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_113592", "species_1247942" ], "products": [ "species_29372", "species_29404", "species_29370" ], "modifiers": [ [ "species_10458314", "catalyst" ] ], "additional_components": [ "Q9W247", "FBgn0034733" ] }, "reaction_10493315": { "compartment": "compartment_876", "id": "reaction_10493315", "reactome": "R-DME-8943279", "name": "GGT dimers hydrolyse GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_1247892" ], "products": [ "species_210382", "species_1247934" ], "modifiers": [ [ "species_10472545", "catalyst" ] ], "additional_components": [ "Q7KUX2", "FBgn0030796", "M9NFP5", "FBgn0025837", "Q9VYR2", "FBgn0030361", "Q9VWT3", "FBgn0030932" ] }, "reaction_10458297": { "compartment": "compartment_70101", "id": "reaction_10458297", "reactome": "R-DME-1247910", "name": "CNDP2:2Mn2+ dimer hydrolyses CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1247904" ], "products": [ "species_111707", "species_29424" ], "modifiers": [ [ "species_10458294", "catalyst" ] ], "additional_components": [ "species_266099", "Q8MT58", "FBgn0259979" ] }, "reaction_10479737": { "compartment": "compartment_70101", "id": "reaction_10479737", "reactome": "R-DME-6785928", "name": "CHAC1,2 cleaves GSH to OPRO and CysGly", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29450" ], "products": [ "species_1247942", "species_1247904" ], "modifiers": [ [ "species_10479732", "catalyst" ] ], "additional_components": [ "FBgn0030411" ] }, "reaction_10458307": { "compartment": "compartment_70101", "id": "reaction_10458307", "reactome": "R-DME-1247922", "name": "GGCT transforms gGluCys to OPRO", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_174393" ], "products": [ "species_111707", "species_1247942" ], "modifiers": [ [ "species_10458304", "catalyst" ] ], "additional_components": [ "Q8IQT0", "FBgn0052196" ] }, "reaction_10478153": { "compartment": "compartment_17957", "id": "reaction_10478153", "reactome": "R-DME-5693724", "name": "ESD dimer hydrolyses S-FGSH to GSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693723" ], "products": [ "species_158543", "species_194712" ], "modifiers": [ [ "species_10478150", "catalyst" ] ], "additional_components": [ "Q7KSB5", "FBgn0038771" ] }, "reaction_10477976": { "compartment": "compartment_70101", "id": "reaction_10477976", "reactome": "R-DME-5692232", "name": "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29366", "species_5692212" ], "products": [ "species_5692216", "species_29364" ], "modifiers": [ [ "species_10475407", "catalyst" ] ], "additional_components": [ "FBgn0035476" ] }, "reaction_10438535": { "compartment": "compartment_17957", "id": "reaction_10438535", "reactome": "R-DME-176059", "name": "GST trimers transfer GS from GSH to luminal substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_158543", "species_176065" ], "products": [ "species_176048" ], "modifiers": [ [ "species_10438532", "catalyst" ] ], "additional_components": [ "CHEBI:30725", "CHEBI:27561", "CHEBI:29132", "CHEBI:32639", "CHEBI:2505", "CHEBI:35896", "Q8SY19", "FBgn0025814" ] }, "reaction_10478143": { "compartment": "compartment_17957", "id": "reaction_10478143", "reactome": "R-DME-5693691", "name": "CES1 trimer.CES2 hydrolyse COCN to BEG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113519", "species_5693702" ], "products": [ "species_156540", "species_5693711", "species_5693712" ], "modifiers": [ [ "species_10478140", "catalyst" ] ], "additional_components": [ "P23654", "FBgn0004108", "Q9Y141", "FBgn0027584", "Q9VLA3", "FBgn0032132", "Q8T016", "FBgn0033943", "A1ZA97", "FBgn0034076" ] }, "reaction_10479631": { "compartment": "compartment_70101", "id": "reaction_10479631", "reactome": "R-DME-6784959", "name": "BPHL hydrolyses VACV to ACV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_6784964" ], "products": [ "species_29702", "species_561052" ], "modifiers": [ [ "species_10479628", "catalyst" ] ], "additional_components": [ "FBgn0038974" ] }, "reaction_10478233": { "compartment": "compartment_12045", "id": "reaction_10478233", "reactome": "R-DME-5694077", "name": "EPHX1 hydrates BaP4,5O to BaP4,5-DHD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_5694080" ], "products": [ "species_5694091" ], "modifiers": [ [ "species_10478230", "catalyst" ] ], "additional_components": [ "FBgn0034405" ] }, "reaction_10429084": { "compartment": "compartment_70101", "id": "reaction_10429084", "reactome": "R-DME-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30203", "species_29360" ], "products": [ "species_70106", "species_29510", "species_73473" ], "modifiers": [ [ "species_10429081", "catalyst" ] ], "additional_components": [ "P46415", "FBgn0011768", "species_1562550" ] }, "reaction_10429112": { "compartment": "compartment_70101", "id": "reaction_10429112", "reactome": "R-DME-71735", "name": "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_29416", "species_76194" ], "products": [ "species_111294", "species_76183", "species_76577" ], "modifiers": [ [ "species_10429109", "catalyst" ] ], "additional_components": [ "FBgn0012034" ] }, "reaction_10429094": { "compartment": "compartment_5460", "id": "reaction_10429094", "reactome": "R-DME-71723", "name": "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10429091", "catalyst" ] ], "additional_components": [ "Q9VLC5", "FBgn0012036" ] }, "reaction_10479094": { "compartment": "compartment_5460", "id": "reaction_10479094", "reactome": "R-DME-5696091", "name": "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113532", "species_113526", "species_113521" ], "products": [ "species_113529", "species_29362", "species_113539" ], "modifiers": [ [ "species_10429091", "catalyst" ] ], "additional_components": [ "Q9VLC5", "FBgn0012036" ] }, "reaction_10477985": { "compartment": "compartment_70101", "id": "reaction_10477985", "reactome": "R-DME-5692237", "name": "ADH5 oxidises S-HMGSH to S-FGSH", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5692221", "species_29360" ], "products": [ "species_5692249", "species_70106", "species_73473" ], "modifiers": [ [ "species_10477982", "catalyst" ] ], "additional_components": [ "species_1562550", "P46415", "FBgn0011768" ] }, "reaction_10492075": { "compartment": "compartment_70101", "id": "reaction_10492075", "reactome": "R-DME-8936442", "name": "MARC1,MARC2 reduce N-hydroxylated compounds", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_8936443", "species_73473" ], "products": [ "species_29356", "species_29468", "species_29360" ], "modifiers": [ [ "species_10492072", "catalyst" ] ], "additional_components": [ "A1Z803", "FBgn0033451", "CHEBI:21437", "X2JGK6", "FBgn0036211", "Q9V4N3", "FBgn0264294" ] }, "reaction_10492235": { "compartment": "compartment_70101", "id": "reaction_10492235", "reactome": "R-DME-8937442", "name": "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_163579" ], "products": [ "species_8876730", "species_216762" ], "modifiers": [ [ "species_10492232", "catalyst" ] ], "additional_components": [ "P23654", "FBgn0004108", "Q8T016", "FBgn0033943", "Q9VLA3", "FBgn0032132", "Q9Y141", "FBgn0027584", "A1ZA97", "FBgn0034076" ] }, "reaction_10465054": { "compartment": "compartment_70101", "id": "reaction_10465054", "reactome": "R-DME-2161500", "name": "abacavir [extracellular] => abacavir [cytosol]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2161525" ], "products": [ "species_2161185" ], "modifiers": [ [ "species_10465051", "catalyst" ] ], "additional_components": [ "Q7K3M6", "FBgn0034479", "Q9VDS0", "FBgn0038752", "Q9VDR9", "FBgn0038753", "Q9VDS2", "FBgn0038750", "D2NUL5", "FBgn0264907" ] }, "reaction_10455658": { "compartment": "compartment_876", "id": "reaction_10455658", "reactome": "R-DME-975340", "name": "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10455655", "catalyst" ] ], "additional_components": [ "species_352011", "Q8SWZ1", "FBgn0033558", "Q08832", "FBgn0010240", "P25123", "FBgn0004244", "Q9VXL9", "FBgn0030707", "Q24352", "FBgn0001134", "Q9W0S2", "FBgn0264707" ] }, "reaction_10455765": { "compartment": "compartment_876", "id": "reaction_10455765", "reactome": "R-DME-975449", "name": "GABRR pentamers:GABA transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10455762", "catalyst" ] ], "additional_components": [ "species_352011", "Q8SWZ1", "FBgn0033558", "Q08832", "FBgn0010240", "P25123", "FBgn0004244" ] }, "reaction_10435001": { "compartment": "compartment_70101", "id": "reaction_10435001", "reactome": "R-DME-114683", "name": "Phosphorylation of Platelet Sec-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10434995", "species_113592" ], "products": [ "species_29370", "species_10434998" ], "modifiers": [ [ "species_10434975", "catalyst" ] ], "additional_components": [ "FBgn0004574", "FBgn0004574", "species_114519", "species_33625", "species_74016", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10452783": { "compartment": "compartment_876", "id": "reaction_10452783", "reactome": "R-DME-481009", "name": "Exocytosis of platelet dense granule content", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452699" ], "products": [ "species_10452781" ], "modifiers": [], "additional_components": [ "species_29438", "Q9VH14", "FBgn0025879", "species_29370", "species_29926", "Q9VN93", "FBgn0260462", "Q9VKY4", "FBgn0032228", "species_113592", "species_29372", "Q24276", "FBgn0011573", "species_74016", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "Q7K187", "FBgn0030330", "species_114523", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "species_29420", "species_113541", "species_74016", "species_29438", "Q9VH14", "FBgn0025879", "species_29370", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "species_113541", "species_29926", "species_113592", "Q7K187", "FBgn0030330", "Q9VN93", "FBgn0260462", "Q9VKY4", "FBgn0032228", "species_114523", "species_29372", "Q24276", "FBgn0011573", "species_29420", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617" ] }, "reaction_10452814": { "compartment": "compartment_876", "id": "reaction_10452814", "reactome": "R-DME-481010", "name": "Surface deployment of platelet dense granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452802" ], "products": [ "species_10452812" ], "modifiers": [], "additional_components": [ "B7YZX0", "FBgn0032797", "Q9VLH1", "FBgn0032074", "Q9V9S0", "FBgn0032949", "O76901", "FBgn0025382", "O76901", "FBgn0025382", "B7YZX0", "FBgn0032797", "Q9VLH1", "FBgn0032074", "Q9V9S0", "FBgn0032949" ] }, "reaction_10444110": { "compartment": "compartment_161320", "id": "reaction_10444110", "reactome": "R-DME-351341", "name": "Exocytosis of Proactivator polypeptide", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444102" ], "products": [ "species_10444108" ], "modifiers": [], "additional_components": [ "Q9Y125", "FBgn0000416", "Q9VLS0", "FBgn0031996", "Q9Y125", "FBgn0000416", "Q9VLS0", "FBgn0031996" ] }, "reaction_10452605": { "compartment": "compartment_876", "id": "reaction_10452605", "reactome": "R-DME-481007", "name": "Exocytosis of platelet alpha granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452245" ], "products": [ "species_10452603" ], "modifiers": [], "additional_components": [ "Q7JQR3", "FBgn0033814", "Q9VLU2", "FBgn0031975", "Q9VK28", "FBgn0032479", "Q8SXT3", "FBgn0034262", "Q9VK22", "FBgn0032484", "Q9VKG1", "FBgn0015400", "D0IQL1", "FBgn0034540", "Q9VJN8", "FBgn0028518", "Q9VK54", "FBgn0015399", "A0A4D6K327", "FBgn0261509", "Q9V430", "FBgn0028370", "O97365", "FBgn0026562", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "Q9VME7", "FBgn0031804", "Q95SM8", "FBgn0050281", "Q8IRM2", "FBgn0030164", "Q7KT80", "FBgn0051832", "B7Z0B2", "FBgn0035452", "A1Z7G6", "FBgn0033312", "Q9W302", "FBgn0030163", "Q9VX04", "FBgn0030880", "O77277", "FBgn0025615", "Q9VX97", "FBgn0030803", "A1Z9D7", "FBgn0000119", "P18091", "FBgn0000667", "Q9VWP6", "FBgn0030964", "Q9I7L4", "FBgn0037481", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VLT3", "FBgn0267488", "Q7K1H0", "FBgn0052066", "Q8SWU7", "FBgn0030151", "P14599", "FBgn0000108", "Q960F7", "FBgn0037391", "Q9VU94", "FBgn0029167", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "P07713", "FBgn0000490", "Q9VN86", "FBgn0037298", "Q9W5T4", "FBgn0250830", "Q9VM97", "FBgn0031850", "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688", "Q9W0A0", "FBgn0027594", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9VEY5", "FBgn0038400", "Q9VH14", "FBgn0025879", "D0IQL1", "FBgn0034540", "A0A4D6K327", "FBgn0261509", "Q9VKG1", "FBgn0015400", "Q9VK54", "FBgn0015399", "Q9VK28", "FBgn0032479", "Q9VK22", "FBgn0032484", "Q9VJN8", "FBgn0028518", "Q9V430", "FBgn0028370", "Q8SXT3", "FBgn0034262", "Q7JQR3", "FBgn0033814", "Q9VWB4", "FBgn0036969", "Q9VVW1", "FBgn0015586", "Q9VPH9", "FBgn0036970", "Q9VLZ8", "FBgn0083141", "Q9VLV3", "FBgn0053121", "Q9VLU4", "FBgn0031973", "Q9VLQ7", "FBgn0028987", "Q9VL44", "FBgn0032178", "Q9VII7", "FBgn0028986", "Q9VH46", "FBgn0037772", "Q9VFC2", "FBgn0028984", "Q9VFC1", "FBgn0038299", "Q9VA48", "FBgn0039795", "Q9V3N1", "Spn27A", "Q8SZF4", "FBgn0033115", "Q8SYY7", "FBgn0044011", "Q7YTY6", "FBgn0028988", "Q7KA66", "FBgn0024294", "Q7K8Y5", "FBgn0265137", "Q7K508", "FBgn0033574", "Q7JWX3", "FBgn0002930", "Q7JV69", "FBgn0028983", "Q4V3G2", "FBgn0034195", "Q3HKQ3", "FBgn0052203", "Q0E8V6", "FBgn0051902", "Q0E8C8", "FBgn0262057", "A1Z6V5", "FBgn0024293", "A1Z6R4", "FBgn0033113", "A1Z6R3", "FBgn0033112", "A1Z6I3", "FBgn0263109", "O97365", "FBgn0026562", "P07713", "FBgn0000490", "Q9W0A0", "FBgn0027594", "Q9VBF5", "FBgn0039425", "P07764", "FBgn0000064", "Q9VH14", "FBgn0025879", "Q9VLU2", "FBgn0031975", "P18091", "FBgn0000667", "Q9VM97", "FBgn0031850", "A1Z9D7", "FBgn0000119", "Q9VN86", "FBgn0037298", "Q9VWP6", "FBgn0030964", "Q9W5T4", "FBgn0250830", "Q9VZI3", "FBgn0035498", "Q9VVD2", "FBgn0036688", "Q9VLT3", "FBgn0267488", "Q9NFV8", "FBgn0041183", "Q9NFV7", "FBgn0041182", "M9PDR0", "FBgn0041180", "Q9VLY7", "FBgn0041181", "Q9VX97", "FBgn0030803", "O77277", "FBgn0025615", "Q9VU94", "FBgn0029167", "P14599", "FBgn0000108", "Q9I7L4", "FBgn0037481", "Q9V4E6", "FBgn0039914", "P54631", "FBgn0005590", "P27091", "FBgn0024234", "Q7K1H0", "FBgn0052066", "Q8SWU7", "FBgn0030151", "Q960F7", "FBgn0037391", "A1Z7G6", "FBgn0033312", "Q8IRM2", "FBgn0030164", "Q9VX04", "FBgn0030880", "Q7KT80", "FBgn0051832", "Q9VME7", "FBgn0031804", "B7Z0B2", "FBgn0035452", "Q95SM8", "FBgn0050281", "Q9W302", "FBgn0030163", "Q9VEY5", "FBgn0038400" ] }, "reaction_10453019": { "compartment": "compartment_70101", "id": "reaction_10453019", "reactome": "R-DME-482772", "name": "Release of platelet cytosolic components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452947" ], "products": [ "species_10453017" ], "modifiers": [], "additional_components": [ "Q07327", "FBgn0004574", "Q7JVP4", "FBgn0033155", "P61851", "FBgn0003462", "Q9VSL8", "FBgn0260442", "Q9VU68", "FBgn0260049", "Q9XZ63", "FBgn0027095", "O46037", "FBgn0004397", "Q9VZI1", "FBgn0035499", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "Q9VEN1", "FBgn0014141", "Q9V426", "FBgn0024183", "D2A6L8", "FBgn0265047", "Q9VED6", "FBgn0038565", "P49258", "FBgn0011273", "Q9VMT2", "FBgn0031692", "P48593", "FBgn0004910", "Q9VDI3", "FBgn0038830", "P47949", "FBgn0010424", "Q9VBM1", "FBgn0039373", "P47948", "FBgn0010423", "Q9VBM0", "FBgn0039374", "P47947", "FBgn0013348", "Q7K860", "FBgn0033027", "A1Z777", "FBgn0050378", "P62152", "FBgn0000253", "Q9W2L0", "FBgn0034592", "Q7JVP4", "FBgn0033155", "P61851", "FBgn0003462", "Q9XZ63", "FBgn0027095", "Q9VED6", "FBgn0038565", "Q9VU68", "FBgn0260049", "Q9VZI1", "FBgn0035499", "O46037", "FBgn0004397", "Q07327", "FBgn0004574", "P48593", "FBgn0004910", "P47949", "FBgn0010424", "P47948", "FBgn0010423", "P47947", "FBgn0013348", "A1Z777", "FBgn0050378", "Q9W2L0", "FBgn0034592", "Q9VMT2", "FBgn0031692", "Q9VDI3", "FBgn0038830", "Q9VBM1", "FBgn0039373", "Q9VBM0", "FBgn0039374", "Q7K860", "FBgn0033027", "P62152", "FBgn0000253", "P49258", "FBgn0011273", "Q9VSL8", "FBgn0260442", "Q9VEN1", "FBgn0014141", "Q9V426", "FBgn0024183", "D2A6L8", "FBgn0265047", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743" ] }, "reaction_10452903": { "compartment": "compartment_984", "id": "reaction_10452903", "reactome": "R-DME-482770", "name": "Release of platelet secretory granule components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452899" ], "products": [ "species_10452901" ], "modifiers": [], "additional_components": [ "FBgn0022355", "FBgn0022355" ] }, "reaction_10452882": { "compartment": "compartment_876", "id": "reaction_10452882", "reactome": "R-DME-481044", "name": "Surface deployment of platelet alpha granule membrane components", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452858" ], "products": [ "species_10452880" ], "modifiers": [], "additional_components": [ "Q961B9", "FBgn0036579", "Q9VZN0", "FBgn0052264", "P14599", "FBgn0000108", "Q9W0X9", "FBgn0035085", "B7YZX0", "FBgn0032797", "Q9VID1", "FBgn0032943", "Q9VFH5", "FBgn0038247", "Q9VGG5", "FBgn0037963", "Q9NFV7", "FBgn0041182", "X2JGK6", "FBgn0036211", "E1JI63", "FBgn0035815", "P14599", "FBgn0000108", "Q9W0X9", "FBgn0035085", "Q9VID1", "FBgn0032943", "Q9NFV7", "FBgn0041182", "E1JI63", "FBgn0035815", "X2JGK6", "FBgn0036211", "B7YZX0", "FBgn0032797", "Q961B9", "FBgn0036579", "Q9VZN0", "FBgn0052264", "Q9VGG5", "FBgn0037963", "Q9VFH5", "FBgn0038247" ] }, "reaction_10448864": { "compartment": "compartment_114584", "id": "reaction_10448864", "reactome": "R-DME-429157", "name": "ABCC4 accumulation of dense granule contents", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29370" ], "products": [ "species_114565" ], "modifiers": [ [ "species_10448861", "catalyst" ] ], "additional_components": [ "FBgn0032026" ] }, "reaction_10434977": { "compartment": "compartment_70101", "id": "reaction_10434977", "reactome": "R-DME-114553", "name": "Activation of conventional Protein Kinase C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_33625", "species_114519", "species_74016", "species_10434959" ], "products": [ "species_10434975" ], "modifiers": [ [ "species_114519", "catalyst" ] ], "additional_components": [ "P13677", "FBgn0004784", "P05130", "FBgn0003091", "species_114519", "species_33625", "species_74016", "P05130", "FBgn0003091", "P13677", "FBgn0004784" ] }, "reaction_10457707": { "compartment": "compartment_70101", "id": "reaction_10457707", "reactome": "R-DME-1022127", "name": "Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457703" ], "products": [ "species_10457705" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10443664": { "compartment": "compartment_984", "id": "reaction_10443664", "reactome": "R-DME-265456", "name": "NPC1L1 inactivation by ezetimibe", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_265479", "species_10443660" ], "products": [ "species_10443662" ], "modifiers": [], "additional_components": [ "Q9VRC9", "FBgn0261675", "Q9VL24", "FBgn0024320", "Q9VRC9", "FBgn0261675", "Q9VL24", "FBgn0024320", "species_265479" ] }, "reaction_10439533": { "compartment": "compartment_876", "id": "reaction_10439533", "reactome": "R-DME-189222", "name": "SLC2A5 transports fructose from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189049" ], "products": [ "species_29532" ], "modifiers": [ [ "species_10439530", "catalyst" ] ], "additional_components": [ "FBgn0264574" ] }, "reaction_10439540": { "compartment": "compartment_876", "id": "reaction_10439540", "reactome": "R-DME-189242", "name": "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_189246" ], "products": [ "species_189219" ], "modifiers": [ [ "species_10439537", "catalyst" ] ], "additional_components": [ "species_964746", "species_188995", "species_29532", "species_188995", "species_964746", "species_29532", "Q8IRI6", "FBgn0264574" ] }, "reaction_209376": { "compartment": "compartment_984", "id": "reaction_209376", "reactome": "R-DME-209376", "name": "SPN27A binds to and inhibits EA protease activity", "reversible": "false", "notes": "In dorsoventral patterning, the serpin SPN27A binds to Easter (EA) serine protease. This complex inhibits Spatzle (SPZ) dimer processing.", "reactants": [ "species_205912", "species_206231" ], "products": [ "species_206652" ], "modifiers": [], "additional_components": [ "Q9V3N1", "Spn27A", "P13582", "ProEA" ] }, "reaction_209141": { "compartment": "compartment_984", "id": "reaction_209141", "reactome": "R-DME-209141", "name": "ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane", "reversible": "false", "notes": "On binding to the Toll (TL) receptor ectodomain, Spatzle (SPZ) dimer sheds its Pro-domains. The SPZ dimer binds to the TL ectodomain at its N-terminus.", "reactants": [ "species_206793", "species_206218" ], "products": [ "species_205949", "species_206655" ], "modifiers": [], "additional_components": [ "P48607", "ProSPZ", "P08953", "TL", "P48607", "ProSPZ" ] }, "reaction_209076": { "compartment": "compartment_876", "id": "reaction_209076", "reactome": "R-DME-209076", "name": "SPZ dimer bound TL dimerises at the plasma membrane", "reversible": "false", "notes": "The binding of a Spatzle (SPZ) dimer to the N-terminus of the Toll (TL) receptor ectodomain triggers a conformational change in TL. This results in two discrete regions of the TL receptor ectodomains, one near the N-terminus and the other in the juxtamembrane region, to interact, inducing dimerisation and forming a 2:2 complex. The transmembrane segments of the receptor chains will be forced into close proximity forming additional favourable interactions which stabilise the dimer.", "reactants": [ "species_206655" ], "products": [ "species_206637" ], "modifiers": [], "additional_components": [ "P08953", "TL", "P48607", "ProSPZ", "P08953", "TL", "P48607", "ProSPZ" ] }, "reaction_209156": { "compartment": "compartment_70101", "id": "reaction_209156", "reactome": "R-DME-209156", "name": "MYD88 binds to TUB", "reversible": "false", "notes": "In close proximity to the plasma membrane, the adaptor proteins MYD88 and Tube (TUB) bind together through their death domains.", "reactants": [ "species_206015", "species_206155" ], "products": [ "species_206621" ], "modifiers": [], "additional_components": [ "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214891": { "compartment": "compartment_984", "id": "reaction_214891", "reactome": "R-DME-214891", "name": "Full-length GD is cleaved by an unknown protease", "reversible": "false", "notes": "During early embryonic patterning, Toll (TL) is required for establishing the dorsoventral axis. The TL signal is initiated by activation of its ligand Spatzle (SPZ) by a serine protease cascade. Activation of this cascade is regulated by the probable chaperone protein Windbeutel (WBL) and by Pipe (PIP), a heparan-sulphanotransferase that has been proposed to create a heparin-modified proteoglycan that is required for local activation of the cascade. PIP is the only dorsoventral factor to be expressed on the ventral side of the embryo and is thought to be the key in activating the cascade. The full-length serine protease zymogen, Gastrulation Defective (GD) is cleaved between Arg136 and Lys137. This separates the inhibitory prodomain from the now active mature enzyme. How GD is activated remains uncertain, although a direct interaction with Nudel (NDL) or autoproteolytic processing cannot be ruled out.", "reactants": [ "species_214753" ], "products": [ "species_214276", "species_214754" ], "modifiers": [ [ "species_214274", "catalyst" ] ], "additional_components": [] }, "reaction_209130": { "compartment": "compartment_984", "id": "reaction_209130", "reactome": "R-DME-209130", "name": "Full-length SPZ dimer is cleaved by EA/SPE serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the trypsin-like serine protease Easter (EA) is known to cleave full-length Spatzle (SPZ) dimer between residues Arg220 and Val221. This frees the Pro-domain and the C-terminal SPZ dimer aka C-106. In the innate immunity response, the serine protease cleavage enzyme is the Spatzle-processing enzyme aka SPE (CG16705). The Pro-domains and the SPZ dimer remain associated after cleavage.", "reactants": [ "species_206598" ], "products": [ "species_206793" ], "modifiers": [ [ "species_206576", "catalyst" ] ], "additional_components": [ "P48607", "ProSPZ", "P48607", "ProSPZ", "Q9VCJ8", "SPE", "P13582", "ProEA" ] }, "reaction_214953": { "compartment": "compartment_984", "id": "reaction_214953", "reactome": "R-DME-214953", "name": "Full-length SNK is cleaved by GD serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the full-length serine protease zymogen, Snake (SNK), is cleaved by active Gastrulation Defective (GD) serine protease between residues Leu185 and Ile186. The removal of the prodomain results in an active SNK protease.", "reactants": [ "species_214747" ], "products": [ "species_214750", "species_214280" ], "modifiers": [ [ "species_214276", "catalyst" ] ], "additional_components": [] }, "reaction_214853": { "compartment": "compartment_70101", "id": "reaction_214853", "reactome": "R-DME-214853", "name": "WEK and MYD88:TUB bind to the TL receptor", "reversible": "false", "notes": "Spatzle (SPZ) dimer binding leads to Toll (TL) receptor homodimerisation and activation. In dorsoventral patterning in Drosophila embryos, the zinc finger containing adaptor protein Weckle, (WEK) binds to both the TL receptor cytoplasmic domain and the adaptor protein MYD88, which in complex with Tube (TUB), also binds to TL. In addition, WEK forms dimers through its N-terminal region.", "reactants": [ "species_206621", "species_206637", "species_214745" ], "products": [ "species_214743" ], "modifiers": [], "additional_components": [ "P22812", "TUB", "Q7K105", "MYD88", "P08953", "TL", "P48607", "ProSPZ", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_209100": { "compartment": "compartment_70101", "id": "reaction_209100", "reactome": "R-DME-209100", "name": "MYD88:TUB binds to TL receptor", "reversible": "false", "notes": "Upon Spatzle (SPZ) dimer binding, leading to Toll (TL) receptor homodimerisation and activation, MYD88:TUB complex binds to the endoplasmic Toll/Interleukin-1 receptor (TIR) domain of TL receptor at the plasma membrane.", "reactants": [ "species_206621", "species_206637" ], "products": [ "species_206600" ], "modifiers": [], "additional_components": [ "P22812", "TUB", "Q7K105", "MYD88", "P08953", "TL", "P48607", "ProSPZ", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214956": { "compartment": "compartment_984", "id": "reaction_214956", "reactome": "R-DME-214956", "name": "Full-length EA is cleaved by SNK serine protease", "reversible": "false", "notes": "In dorsoventral patterning, the full-length serine protease zymogen, Easter (EA) is cleaved by active serine protease, Snake (SNK), between residues Arg127 and Ile128. The removal of the inhibitory prodomain results in an active EA serine protease.", "reactants": [ "species_214751" ], "products": [ "species_205912", "species_214755" ], "modifiers": [ [ "species_214280", "catalyst" ] ], "additional_components": [] }, "reaction_214871": { "compartment": "compartment_70101", "id": "reaction_214871", "reactome": "R-DME-214871", "name": "Phosphorylated CACT is degraded in the cytosol", "reversible": "false", "notes": "In humans, the Cactus (CACT) orthologue IkappaB is polyubiquitinated by the beta-TrCP E3 ubiquitin ligase containing complex. This marks it for degradation by the 26S proteosome. It is believed that CACT is degraded in a similar manner, however, a Drosophila E3 ubiquitin ligase that acts in the Toll pathway has yet to be identified. The obvious candidate, the closest beta-TrCP orthologue Slimb (SLMB) has produced contradictory evidence on whether it participates in the Toll pathway (Spencer et al., 1999; Leulier et al., 2003).", "reactants": [ "species_214741" ], "products": [ "species_214728" ], "modifiers": [ [ "species_206968", "catalyst" ] ], "additional_components": [ "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P15330", "dl", "P98149", "Dif", "Q9NHX7", "PROSbeta5", "Q9VM46", "CG13779", "P40301", "Prosalpha2", "Q9V5C6", "Prosalpha7", "P25161", "Rpn3", "Q9V3H2", "Rpn11", "Q95083", "Prosalpha5", "Q9VW54", "Rpn1", "Q7KMQ0", "Rpt1", "O18413", "Rpt6", "Q9V3P6", "Rpn2", "Q9VUJ1", "Prosbeta2", "Q9XYN7", "Prosbeta3", "Q9VJJ0", "Prosbeta4", "P55035", "Rpn10", "Q9Y1A7", "MND", "P40304", "Prosbeta6", "Q9V436", "Rpn12", "Q9V3Z4", "Rpn5", "Q9V405", "Rpt3", "Q9XZJ4", "Prosalpha1", "Q9V3V6", "Rpt5", "Q9V3G7", "Rpn7", "P48601", "Rpt2", "Q9VNA5", "Prosbeta7", "P22769", "Prosalpha4", "Q9VKZ8", "Usp14", "Q8SYQ2", "I(2)05070", "Q9XZ61", "Uch-L5", "P12881", "Prosalpha6", "Q9U7A2", "RPT4", "Q7KLV9", "Rpn6", "P26270", "Rpn8", "Q7KMP8", "Rpn9" ] }, "reaction_214864": { "compartment": "compartment_70101", "id": "reaction_214864", "reactome": "R-DME-214864", "name": "Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Once phosphorylated, Cactus (CACT), in complex with the Dorsal/Dorsal-related immunity factor (DL/DIF) homodimer, dissociates from the Toll (TL) receptor 'signalling complex'.", "reactants": [ "species_214748" ], "products": [ "species_214741", "species_206693" ], "modifiers": [], "additional_components": [ "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL" ] }, "reaction_214847": { "compartment": "compartment_70101", "id": "reaction_214847", "reactome": "R-DME-214847", "name": "Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Once phosphorylated, Cactus (CACT), in complex with the Dorsal (DL) homodimer, dissociates from the Toll (TL) receptor 'signalling complex'.", "reactants": [ "species_214749" ], "products": [ "species_214759", "species_214752" ], "modifiers": [], "additional_components": [ "P15330", "dl", "Q03017", "phospho-cact", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "P15330", "dl", "Q03017", "phospho-cact" ] }, "reaction_209057": { "compartment": "compartment_70101", "id": "reaction_209057", "reactome": "R-DME-209057", "name": "Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "On binding to the 'signalling complex', the Ser/Thr kinase Pelle (PLL) is activated and autophosphorylates.", "reactants": [ "species_206889", "species_113592" ], "products": [ "species_29370", "species_206693" ], "modifiers": [ [ "species_206889", "catalyst" ] ], "additional_components": [ "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q05652", "Phospho PLL", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214859": { "compartment": "compartment_70101", "id": "reaction_214859", "reactome": "R-DME-214859", "name": "Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "On binding to the 'signalling complex', the Ser/Thr kinase Pelle (PLL) is activated and autophosphorylates.", "reactants": [ "species_113592", "species_214742" ], "products": [ "species_29370", "species_214759" ], "modifiers": [ [ "species_214742", "catalyst" ] ], "additional_components": [ "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214845": { "compartment": "compartment_70101", "id": "reaction_214845", "reactome": "R-DME-214845", "name": "CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Pelle (PLL) may be the kinase that phosphorylates both Cactus (CACT) and the Dorsal (DL) homodimer but the biochemical evidence for this is currently inconclusive. CACT is phosphorylated in its N-terminal half within the first 125 residues. In this region, there are two IKK target-like motifs, involving Ser74 and Ser78 in one, and Ser116 in the other. However, it is not clear which of these residues need to be phosphorylated. DL homodimer is phosphorylated at both Ser317 residues while associated with CACT.", "reactants": [ "species_113592", "species_214758" ], "products": [ "species_214749", "species_29370" ], "modifiers": [ [ "species_206306", "catalyst" ] ], "additional_components": [ "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P15330", "dl", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "P15330", "dl", "Q03017", "phospho-cact", "Q05652", "Phospho PLL", "Q9VJN5", "WEK", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88" ] }, "reaction_214860": { "compartment": "compartment_70101", "id": "reaction_214860", "reactome": "R-DME-214860", "name": "CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex'", "reversible": "false", "notes": "Pelle (PLL) may be the kinase that phosphorylates both Cactus (CACT) and the Dorsal/Dorsal-related immunity factor (DL/DIF) homodimer but the biochemical evidence for this is currently inconclusive. DL/DIF homodimer is phosphorylated while associated with CACT. DL is phosphorylated on Ser317 while DIF is very likely to be phosphorylated at Ser348 (inferred from DL). CACT is phosphorylated in its N-terminal half within the first 125 residues. In this region, there are two IKK target-like motifs, involving Ser74 and Ser78 in one, and Ser116 in the other. However, it is not clear which of these residues need to be phosphorylated.", "reactants": [ "species_214744", "species_113592" ], "products": [ "species_214748", "species_29370" ], "modifiers": [ [ "species_206306", "catalyst" ] ], "additional_components": [ "P08953", "TL", "P48607", "ProSPZ", "P98149", "Dif", "P15330", "dl", "Q03017", "phospho-cact", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL", "P15330", "dl", "P98149", "Dif", "Q03017", "phospho-cact", "P08953", "TL", "P48607", "ProSPZ", "P22812", "TUB", "Q7K105", "MYD88", "Q05652", "Phospho PLL" ] }, "reaction_10466911": { "compartment": "compartment_876", "id": "reaction_10466911", "reactome": "R-DME-2730862", "name": "Autophosphorylation of LYN kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466905" ], "products": [ "species_29370", "species_10466908" ], "modifiers": [ [ "species_10466905", "catalyst" ] ], "additional_components": [ "FBgn0262733", "FBgn0262733", "FBgn0262733" ] }, "reaction_10441884": { "compartment": "compartment_70101", "id": "reaction_10441884", "reactome": "R-DME-202164", "name": "Translocation of PDK1 to Plasma membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441880", "species_202277" ], "products": [ "species_10441882" ], "modifiers": [], "additional_components": [ "species_202247", "species_179838", "species_202247", "species_179838", "Q9W0V1", "Pdk1" ] }, "reaction_10466859": { "compartment": "compartment_876", "id": "reaction_10466859", "reactome": "R-DME-2730842", "name": "PI3K associates with phosphorylated GAB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466855", "species_10431820" ], "products": [ "species_10466857" ], "modifiers": [], "additional_components": [ "Q9VZZ9", "FBgn0016794", "species_179838", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VZZ9", "FBgn0016794", "species_179838", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466946": { "compartment": "compartment_876", "id": "reaction_10466946", "reactome": "R-DME-2730870", "name": "Phosphorylation of PIP2 to PIP3 by PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10466857", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "Q9VZZ9", "FBgn0016794", "species_179838", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466861": { "compartment": "compartment_70101", "id": "reaction_10466861", "reactome": "R-DME-2730844", "name": "Interaction of GRB2:SOS complex with p-SHC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431797", "species_10465768" ], "products": [ "species_10465770" ], "modifiers": [], "additional_components": [ "Q08012", "FBgn0004638", "P26675", "Sos", "FBgn0015296", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466844": { "compartment": "compartment_876", "id": "reaction_10466844", "reactome": "R-DME-2730841", "name": "Phosphorylation and activation of VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466842" ], "products": [ "species_10466835", "species_29370" ], "modifiers": [ [ "species_179838", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466840": { "compartment": "compartment_70101", "id": "reaction_10466840", "reactome": "R-DME-2730840", "name": "Activation of RAC1 by VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10466835", "species_428485" ], "products": [ "species_29420", "species_10466837" ], "modifiers": [ [ "species_10466835", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "P40792", "RAC1_DROME", "species_29420", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos" ] }, "reaction_10466952": { "compartment": "compartment_876", "id": "reaction_10466952", "reactome": "R-DME-2730889", "name": "Recruitment of PAK to the membrane by binding active RAC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10466884", "species_10466837" ], "products": [ "species_10466886" ], "modifiers": [], "additional_components": [ "B7Z0W0", "FBgn0267698", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_179838", "P40792", "RAC1_DROME", "species_29438", "Q9NHV9", "FBgn0040068", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "species_179838", "P40792", "RAC1_DROME", "species_29438", "B7Z0W0", "FBgn0267698" ] }, "reaction_10466903": { "compartment": "compartment_876", "id": "reaction_10466903", "reactome": "R-DME-2730858", "name": "Autophosphorylation of BTK/ITK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10466826" ], "products": [ "species_10466900", "species_29370" ], "modifiers": [ [ "species_10466826", "catalyst" ] ], "additional_components": [ "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "species_179838", "P08630", "FBgn0003502", "P08630", "FBgn0003502", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "species_179838", "Q9VXH3", "FBgn0003416", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9NHV9", "FBgn0040068", "species_179838", "P08630", "FBgn0003502" ] }, "reaction_10466871": { "compartment": "compartment_70101", "id": "reaction_10466871", "reactome": "R-DME-2730847", "name": "Hydrolysis of PIP2 by PLCG", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10466868", "catalyst" ] ], "additional_components": [ "Q9NHV9", "FBgn0040068", "species_179838", "P08630", "FBgn0003502", "Q9V3C8", "FBgn0015296", "Q08012", "FBgn0004638", "P26675", "Sos", "Q9VXH3", "FBgn0003416" ] }, "reaction_10477775": { "compartment": "compartment_70101", "id": "reaction_10477775", "reactome": "R-DME-5690808", "name": "UCHL3, SENP8 cleave NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477766" ], "products": [ "species_10477770", "species_10477772" ], "modifiers": [ [ "species_10477766", "catalyst" ] ], "additional_components": [ "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725", "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725", "FBgn0032725", "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725" ] }, "reaction_10475484": { "compartment": "compartment_70101", "id": "reaction_10475484", "reactome": "R-DME-5665854", "name": "ADRM1:26S proteaseome binds UCHL5", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475473", "species_10475480" ], "products": [ "species_10475482" ], "modifiers": [], "additional_components": [ "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q9XZ61", "Uch-L5" ] }, "reaction_10477752": { "compartment": "compartment_7660", "id": "reaction_10477752", "reactome": "R-DME-5690785", "name": "BAP1 binds Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477180", "species_10477741" ], "products": [ "species_10477743" ], "modifiers": [], "additional_components": [ "FBgn0262166", "FBgn0039904", "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166" ] }, "reaction_10477720": { "compartment": "compartment_70101", "id": "reaction_10477720", "reactome": "R-DME-5690319", "name": "UCHL1, UCHL3 cleave ubiquitin adducts", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10477715" ], "products": [ "species_1131871", "species_10477717" ], "modifiers": [ [ "species_10477715", "catalyst" ] ], "additional_components": [ "P35122", "FBgn0010288", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P35122", "FBgn0010288", "P35122", "FBgn0010288", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10477175": { "compartment": "compartment_7660", "id": "reaction_10477175", "reactome": "R-DME-5689544", "name": "UCHL5 binds INO80 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477169", "species_10477171" ], "products": [ "species_10477173" ], "modifiers": [], "additional_components": [ "Q7K012", "FBgn0025716", "Q9Y0Z1", "FBgn0027503", "Q8ST83", "FBgn0002521", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "Q9W3D4", "FBgn0040929", "Q9VH07", "FBgn0040078", "A1Z6E8", "FBgn0033019", "A1Z8D5", "FBgn0033566", "Q9VX09", "FBgn0030877", "Q9VFH4", "FBgn0086686", "Q9VEC3", "FBgn0038576", "Q4V604", "FBgn0052202", "Q9VDY1", "FBgn0086613", "Q9VZJ3", "FBgn0263832", "Q9XZ61", "Uch-L5", "Q7K012", "FBgn0025716", "Q9Y0Z1", "FBgn0027503", "Q8ST83", "FBgn0002521", "P10987", "FBgn0000042", "P10981", "FBgn0000046", "P02574", "FBgn0000045", "P83967", "FBgn0000047", "P53501", "FBgn0000044", "P45891", "FBgn0011743", "Q9W3D4", "FBgn0040929", "Q9VH07", "FBgn0040078", "A1Z6E8", "FBgn0033019", "A1Z8D5", "FBgn0033566", "Q9VX09", "FBgn0030877", "Q9VFH4", "FBgn0086686", "Q9VEC3", "FBgn0038576", "Q4V604", "FBgn0052202", "Q9VDY1", "FBgn0086613", "Q9VZJ3", "FBgn0263832" ] }, "reaction_10477750": { "compartment": "compartment_7660", "id": "reaction_10477750", "reactome": "R-DME-5690759", "name": "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10477743" ], "products": [ "species_10477745", "species_10477747" ], "modifiers": [ [ "species_10477743", "catalyst" ] ], "additional_components": [ "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166", "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9V4C8", "FBgn0039904", "Q7K5N4", "FBgn0262166" ] }, "reaction_10475507": { "compartment": "compartment_70101", "id": "reaction_10475507", "reactome": "R-DME-5665871", "name": "ADRM1 binds 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427203", "species_10475478" ], "products": [ "species_10475480" ], "modifiers": [], "additional_components": [ "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "FBgn0033886", "Q7K2G1", "FBgn0033886", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10477216": { "compartment": "compartment_7660", "id": "reaction_10477216", "reactome": "R-DME-5689630", "name": "BAP1 binds BAP1-interacting complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477212", "species_10477180" ], "products": [ "species_10477214" ], "modifiers": [], "additional_components": [ "Q8ST83", "FBgn0002521", "Q9V4C8", "FBgn0039904", "Q7KJA9", "FBgn0261403", "M9PF47", "FBgn0036134", "Q9W3Q5", "FBgn0029504", "Q9V727", "FBgn0261823", "FBgn0262166", "Q7K5N4", "FBgn0262166", "Q8ST83", "FBgn0002521", "Q9V4C8", "FBgn0039904", "Q7KJA9", "FBgn0261403", "M9PF47", "FBgn0036134", "Q9W3Q5", "FBgn0029504", "Q9V727", "FBgn0261823" ] }, "reaction_10455103": { "compartment": "compartment_984", "id": "reaction_10455103", "reactome": "R-DME-917888", "name": "apoTF binds 2Fe3+ to form holoTF", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10452901", "species_912516" ], "products": [ "species_10455101" ], "modifiers": [], "additional_components": [ "FBgn0022355", "species_1222611", "Q9VWV6", "FBgn0022355" ] }, "reaction_10477961": { "compartment": "compartment_70101", "id": "reaction_10477961", "reactome": "R-DME-5691108", "name": "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477840", "species_10426987" ], "products": [ "species_10477952" ], "modifiers": [ [ "species_10477958", "catalyst" ] ], "additional_components": [ "Q9VGZ3", "FBgn0024957", "Q9VCV4", "FBgn0024958", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q9VGZ3", "FBgn0024957", "Q9VCV4", "FBgn0024958", "Q9VJ33", "FBgn0032725", "Q24311", "Cul1", "O77430", "SkpA" ] }, "reaction_10477944": { "compartment": "compartment_5460", "id": "reaction_10477944", "reactome": "R-DME-5691107", "name": "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113533", "species_113531", "species_113529" ], "products": [ "species_5691135" ], "modifiers": [ [ "species_10477941", "catalyst" ] ], "additional_components": [ "Q9VYH1", "FBgn0030449" ] }, "reaction_10477831": { "compartment": "compartment_70101", "id": "reaction_10477831", "reactome": "R-DME-5690873", "name": "ACO1 binds 4Fe-4S", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477827", "species_5690881" ], "products": [ "species_10477829" ], "modifiers": [], "additional_components": [ "FBgn0024957", "Q9VGZ3", "FBgn0024957" ] }, "reaction_10477845": { "compartment": "compartment_70101", "id": "reaction_10477845", "reactome": "R-DME-5690911", "name": "ACO1:4Fe-4S isomerises CIT to ISCIT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_76190" ], "products": [ "species_389545" ], "modifiers": [ [ "species_10477829", "catalyst" ] ], "additional_components": [ "Q9VGZ3", "FBgn0024957" ] }, "reaction_10455096": { "compartment": "compartment_74700", "id": "reaction_10455096", "reactome": "R-DME-917841", "name": "Acidification of Tf:TfR1 containing endosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_70106", "species_113592" ], "products": [ "species_29372", "species_29370", "species_74722" ], "modifiers": [ [ "species_10431765", "catalyst" ] ], "additional_components": [ "Q24583", "FBgn0262512", "Q27331", "FBgn0263598", "Q9V3J1", "FBgn0027779", "Q9V7N5", "FBgn0262511", "P54611", "FBgn0283535", "Q9XZH6", "FBgn0283536", "P31409", "FBgn0005671", "Q9V7D2", "FBgn0022097", "Q9XZ10", "FBgn0028671", "Q9VKF6", "FBgn0032373", "Q9VE77", "FBgn0038613", "Q9VE75", "FBgn0028670", "A1ZBF7", "FBgn0028669", "P23380", "FBgn0262736", "Q9W4P5", "FBgn0285910", "Q9VCQ3", "FBgn0039058", "Q9VZE9", "FBgn0035521", "Q9VZG7", "FBgn0028664", "Q9VP18", "FBgn0028663", "Q9VEQ6", "FBgn0038458", "Q9VFE3", "FBgn0028662", "Q7JR49", "FBgn0262515" ] }, "reaction_10455111": { "compartment": "compartment_74700", "id": "reaction_10455111", "reactome": "R-DME-917936", "name": "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_917810" ], "products": [ "species_71067" ], "modifiers": [ [ "species_10455108", "catalyst" ] ], "additional_components": [ "FBgn0261361" ] }, "reaction_10459940": { "compartment": "compartment_70101", "id": "reaction_10459940", "reactome": "R-DME-1562626", "name": "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_71067", "species_29368" ], "products": [ "species_5691103" ], "modifiers": [ [ "species_10449619", "catalyst" ] ], "additional_components": [ "Q9VYH1", "FBgn0030449" ] }, "reaction_10477970": { "compartment": "compartment_70101", "id": "reaction_10477970", "reactome": "R-DME-5691131", "name": "CANDI binds CUL1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438329", "species_10477966" ], "products": [ "species_10477968" ], "modifiers": [], "additional_components": [ "FBgn0027568", "Q9VKY2", "FBgn0027568", "Q24311", "Cul1" ] }, "reaction_10493560": { "compartment": "compartment_70616", "id": "reaction_10493560", "reactome": "R-DME-8949178", "name": "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8949232" ], "products": [ "species_8949220" ], "modifiers": [ [ "species_10493557", "catalyst" ] ], "additional_components": [ "Q7JX57", "FBgn0062440", "Q8IQ70", "FBgn0042185", "A2VEI2", "FBgn0031893" ] }, "reaction_10493619": { "compartment": "compartment_70616", "id": "reaction_10493619", "reactome": "R-DME-8949649", "name": "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493605" ], "products": [ "species_10493607", "species_10493553", "species_10493601" ], "modifiers": [ [ "species_10493616", "catalyst" ] ], "additional_components": [ "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q7JX57", "FBgn0062440", "FBgn0062440", "FBgn0062440", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q7K3W2", "FBgn0033235", "Q9VFF0", "FBgn0038271" ] }, "reaction_10493622": { "compartment": "compartment_70616", "id": "reaction_10493622", "reactome": "R-DME-8949659", "name": "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493553" ], "products": [], "modifiers": [ [ "species_10493601", "catalyst" ] ], "additional_components": [ "FBgn0062440", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551" ] }, "reaction_10493624": { "compartment": "compartment_70616", "id": "reaction_10493624", "reactome": "R-DME-8949661", "name": "C2orf47:AFG3L2 binds the transit peptide of SMDT1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493603", "species_10493601" ], "products": [ "species_10493605" ], "modifiers": [], "additional_components": [ "FBgn0062440", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q9W0X3", "FBgn0035088", "Q9W4W8", "FBgn0024992", "F3YDF1", "FBgn0034792", "Q8T4G5", "FBgn0036702", "species_1562550", "P24156", "FBgn0002031", "A8DYI6", "FBgn0010551", "Q7JX57", "FBgn0062440" ] }, "reaction_10493629": { "compartment": "compartment_70616", "id": "reaction_10493629", "reactome": "R-DME-8949688", "name": "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2889072", "species_8949220" ], "products": [ "species_8949232", "species_2889083" ], "modifiers": [ [ "species_10493626", "catalyst" ] ], "additional_components": [ "FBgn0033324" ] }, "reaction_10471663": { "compartment": "compartment_70101", "id": "reaction_10471663", "reactome": "R-DME-5339538", "name": "MAGT1 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10471660", "catalyst" ] ], "additional_components": [ "FBgn0032015" ] }, "reaction_10471086": { "compartment": "compartment_70101", "id": "reaction_10471086", "reactome": "R-DME-5226979", "name": "ADD1:ADD2 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471077", "species_10471082" ], "products": [ "species_10471084" ], "modifiers": [], "additional_components": [ "Q02645", "FBgn0263391", "FBgn0051352", "E1JIH3", "FBgn0051352", "Q02645", "FBgn0263391" ] }, "reaction_10471094": { "compartment": "compartment_70101", "id": "reaction_10471094", "reactome": "R-DME-5226999", "name": "ADD1:ADD3 binds DMTN", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471090", "species_10471082" ], "products": [ "species_10471092" ], "modifiers": [], "additional_components": [ "Q02645", "FBgn0263391", "FBgn0051352", "E1JIH3", "FBgn0051352", "Q02645", "FBgn0263391" ] }, "reaction_10471636": { "compartment": "compartment_70101", "id": "reaction_10471636", "reactome": "R-DME-5336453", "name": "NIPAs transport Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10471627", "catalyst" ] ], "additional_components": [ "FBgn0032451" ] }, "reaction_10471650": { "compartment": "compartment_70101", "id": "reaction_10471650", "reactome": "R-DME-5339528", "name": "TUSC3 transports Mg2+ from extracellular region to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_114632" ], "products": [ "species_29926" ], "modifiers": [ [ "species_10471647", "catalyst" ] ], "additional_components": [ "FBgn0032015" ] }, "reaction_10493197": { "compartment": "compartment_70101", "id": "reaction_10493197", "reactome": "R-DME-8941543", "name": "VRAC heteromer transports I-, Cl- from cytosol to extracellular region", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8941540" ], "products": [ "species_8941541" ], "modifiers": [ [ "species_10493194", "catalyst" ] ], "additional_components": [ "species_352022", "species_209818", "species_209818", "species_352022", "Q0E8W8", "FBgn0035008" ] }, "reaction_10453114": { "compartment": "compartment_876", "id": "reaction_10453114", "reactome": "R-DME-507870", "name": "Aquaporins passively transport water out of cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356" ], "products": [ "species_109276" ], "modifiers": [ [ "species_10453109", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884" ] }, "reaction_10453112": { "compartment": "compartment_876", "id": "reaction_10453112", "reactome": "R-DME-507868", "name": "Aquaporins passively transport water into cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276" ], "products": [ "species_29356" ], "modifiers": [ [ "species_10453109", "catalyst" ] ], "additional_components": [ "Q9V5Z7", "FBgn0015872", "P23645", "FBgn0000180", "Q9W1M4", "FBgn0034882", "D3DMU9", "FBgn0033635", "Q9W1M2", "FBgn0034884" ] }, "reaction_10479551": { "compartment": "compartment_1660541", "id": "reaction_10479551", "reactome": "R-DME-6784729", "name": "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479517" ], "products": [ "species_10479549" ], "modifiers": [], "additional_components": [ "Q24253", "FBgn0010380", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "P29742", "FBgn0000319", "Q9VWA1", "FBgn0024814", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101" ] }, "reaction_10491346": { "compartment": "compartment_161320", "id": "reaction_10491346", "reactome": "R-DME-8876484", "name": "NPC2 transfers CHOL to NPC1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491342", "species_10491338" ], "products": [ "species_10491336", "species_10491344" ], "modifiers": [], "additional_components": [ "FBgn0024320", "species_8848047", "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198", "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198", "species_8848047", "Q9VL24", "FBgn0024320" ] }, "reaction_10491348": { "compartment": "compartment_12045", "id": "reaction_10491348", "reactome": "R-DME-8876485", "name": "CHOL translocates from lysosome membrane to ER membrane", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10491344" ], "products": [ "species_10491342", "species_193384" ], "modifiers": [], "additional_components": [ "species_8848047", "Q9VL24", "FBgn0024320", "FBgn0024320" ] }, "reaction_10491412": { "compartment": "compartment_12045", "id": "reaction_10491412", "reactome": "R-DME-8876696", "name": "SOAT1,2 transfer acyl group to CHOL forming CHEST", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_193384", "species_1500578" ], "products": [ "species_8876704", "species_76194" ], "modifiers": [ [ "species_10491407", "catalyst" ] ], "additional_components": [ "FBgn0037612" ] }, "reaction_10491340": { "compartment": "compartment_161320", "id": "reaction_10491340", "reactome": "R-DME-8876472", "name": "NPC2 binds CHOL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8848047", "species_10491336" ], "products": [ "species_10491338" ], "modifiers": [], "additional_components": [ "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198", "species_8848047", "Q9VH31", "FBgn0037783", "Q9VH32", "FBgn0037782", "Q9VH33", "FBgn0051410", "Q9VQ62", "FBgn0031381", "Q9VA41", "FBgn0039801", "Q9VA42", "FBgn0039800", "Q9VCC8", "FBgn0039154", "Q9VFN7", "FBgn0038198" ] }, "reaction_10437938": { "compartment": "compartment_74700", "id": "reaction_10437938", "reactome": "R-DME-171087", "name": "LDLR [endosome membrane] => LDLR [plasma membrane]", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437930" ], "products": [ "species_10437936" ], "modifiers": [], "additional_components": [ "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101" ] }, "reaction_10479553": { "compartment": "compartment_1660541", "id": "reaction_10479553", "reactome": "R-DME-6784738", "name": "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10479549" ], "products": [ "species_10479547" ], "modifiers": [], "additional_components": [ "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380", "Q7YU01", "FBgn0051092", "A8JRD0", "FBgn0066101", "Q9VWA1", "FBgn0024814", "P29742", "FBgn0000319", "P91926", "FBgn0264855", "Q9VDC3", "FBgn0043012", "O62530", "FBgn0263351", "Q24253", "FBgn0010380" ] }, "reaction_10490897": { "compartment": "compartment_70101", "id": "reaction_10490897", "reactome": "R-DME-8870469", "name": "RGGT geranylgeranylates RAB proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10490631" ], "products": [ "species_10490894", "species_10490892", "species_1132084" ], "modifiers": [ [ "species_10490631", "catalyst" ] ], "additional_components": [ "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "Q9V8W3", "FBgn0026378", "O18335", "FBgn0015790", "A1Z7S3", "FBgn0002567", "Q9V3I2", "FBgn0014010", "M9PE35", "FBgn0035155", "O18332", "FBgn0285937", "O18333", "FBgn0014009", "Q9VQG6", "FBgn0031460", "O18338", "FBgn0262518", "Q9VZ47", "FBgn0052671", "Q8IR98", "FBgn0052670", "Q9W2S9", "FBgn0030221", "Q8IRK8", "FBgn0052673", "Q9W2V3", "FBgn0030200", "Q8IRK9", "FBgn0067052", "Q9VC31", "FBgn0051118", "P25228", "FBgn0005586", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420" ] }, "reaction_10490498": { "compartment": "compartment_70101", "id": "reaction_10490498", "reactome": "R-DME-8870465", "name": "RGGT binds the RAB-binding subunit", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_1131164", "species_10490490", "species_10485779" ], "products": [ "species_10490496" ], "modifiers": [], "additional_components": [ "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "FBgn0026378", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164" ] }, "reaction_10490633": { "compartment": "compartment_70101", "id": "reaction_10490633", "reactome": "R-DME-8870466", "name": "RGGT:CHM binds RABs", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490629", "species_10490496" ], "products": [ "species_10490631" ], "modifiers": [], "additional_components": [ "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "Q9V8W3", "FBgn0026378", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970", "species_1131164", "A1Z7S3", "FBgn0002567", "O18333", "FBgn0014009", "O18332", "FBgn0285937", "O18335", "FBgn0015790", "P25228", "FBgn0005586", "Q9V3I2", "FBgn0014010", "Q9VC31", "FBgn0051118", "Q9W2S9", "FBgn0030221", "O18338", "FBgn0262518", "Q8IRK9", "FBgn0067052", "Q9VZ47", "FBgn0052671", "Q8IRK8", "FBgn0052673", "Q9VQG6", "FBgn0031460", "Q9W2V3", "FBgn0030200", "Q8IR98", "FBgn0052670", "M9PE35", "FBgn0035155", "species_29420" ] }, "reaction_10490492": { "compartment": "compartment_70101", "id": "reaction_10490492", "reactome": "R-DME-8870461", "name": "RABGGTA and RABGGTB bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10490488", "species_10490486" ], "products": [ "species_10490490" ], "modifiers": [], "additional_components": [ "FBgn0028970", "FBgn0037293", "Q9VN77", "FBgn0037293", "Q9XZ68", "FBgn0028970" ] }, "reaction_10468651": { "compartment": "compartment_70101", "id": "reaction_10468651", "reactome": "R-DME-3371590", "name": "HSP70 binds to HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468647", "species_10468649" ], "products": [ "species_10468516" ], "modifiers": [], "additional_components": [ "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474" ] }, "reaction_10468521": { "compartment": "compartment_70101", "id": "reaction_10468521", "reactome": "R-DME-3371422", "name": "ATP hydrolysis by HSP70", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468516" ], "products": [ "species_29372", "species_10468518" ], "modifiers": [ [ "species_10468516", "catalyst" ], [ "species_10468514", "catalyst" ] ], "additional_components": [ "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "species_113592", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474" ] }, "reaction_10498696": { "compartment": "compartment_70101", "id": "reaction_10498696", "reactome": "R-DME-9705925", "name": "Androgens binds AR (in the HSP90 chaperone complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8979218", "species_10473503" ], "products": [ "species_10498694" ], "modifiers": [], "additional_components": [ "species_193057", "species_193079", "species_469662", "CHEBI:29117", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q8WS79", "FBgn0035849" ] }, "reaction_10498553": { "compartment": "compartment_70101", "id": "reaction_10498553", "reactome": "R-DME-9690534", "name": "SH binds NR3C1 (in HSP90:ATP:FKBP4:PTGES3:NR3C1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473346", "species_5618094" ], "products": [ "species_10473348" ], "modifiers": [ [ "species_10498474", "catalyst" ] ], "additional_components": [ "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849" ] }, "reaction_10468612": { "compartment": "compartment_70101", "id": "reaction_10468612", "reactome": "R-DME-3371503", "name": "STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468518", "species_10468600", "species_10468604" ], "products": [ "species_10468514", "species_10468610" ], "modifiers": [], "additional_components": [ "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "FBgn0024352", "P02828", "FBgn0001233", "Q9VFV9", "FBgn0038145", "M9PD23", "FBgn0032474", "P02828", "FBgn0001233", "Q9VPN5", "FBgn0024352", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878" ] }, "reaction_10473507": { "compartment": "compartment_70101", "id": "reaction_10473507", "reactome": "R-DME-5618107", "name": "ATP binding to HSP90 triggers conformation change", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468610", "species_113592" ], "products": [ "species_10473495" ], "modifiers": [], "additional_components": [ "P02828", "FBgn0001233", "Q9VPN5", "FBgn0024352", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_29370", "P11147", "FBgn0266599", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VPN5", "FBgn0024352", "P02828", "FBgn0001233", "species_113592" ] }, "reaction_10498476": { "compartment": "compartment_70101", "id": "reaction_10498476", "reactome": "R-DME-9678925", "name": "NR3C1 binds NR3C1 agonists", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473346", "species_9678859" ], "products": [ "species_10498474" ], "modifiers": [], "additional_components": [ "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849" ] }, "reaction_10473490": { "compartment": "compartment_70101", "id": "reaction_10473490", "reactome": "R-DME-5618080", "name": "HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10473348", "species_10473342" ], "products": [ "species_10473360", "species_10473364" ], "modifiers": [ [ "species_10473488", "catalyst" ] ], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q8WS79", "FBgn0035849", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q9VH95", "FBgn0037728", "species_113592", "Q9VH95", "FBgn0037728", "species_193055", "Q8WS79", "FBgn0035849", "species_469662", "CHEBI:29117", "species_193057", "species_193079", "species_193977", "CHEBI:27584", "CHEBI:16973", "P02828", "FBgn0001233", "species_113592", "species_469662", "species_193977", "species_193055", "CHEBI:27584", "CHEBI:16973", "species_193057", "Q9VH95", "FBgn0037728", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "species_113592", "P37276", "FBgn0261797", "Q9VZ20", "FBgn0030276", "Q7KWG3", "FBgn0053497", "T2FGB0", "FBgn0283434", "Q24246", "FBgn0003654", "Q9W5W4", "FBgn0067861", "B5RJJ8", "FBgn0053499", "Q8IRZ3", "FBgn0052823", "O96860", "FBgn0026141", "Q24117", "FBgn0011760", "P45889", "FBgn0011745", "Q7K130", "FBgn0033206", "Q9VIZ1", "FBgn0086446", "Q9VJQ6", "FBgn0040228", "Q9VWE8", "FBgn0031050", "Q9W2N0", "FBgn0034577", "P48603", "FBgn0011570", "P13496", "FBgn0001108", "Q9W1V8", "FBgn0010622", "Q7K2D2", "FBgn0021825", "species_29438", "species_29420" ] }, "reaction_10473505": { "compartment": "compartment_70101", "id": "reaction_10473505", "reactome": "R-DME-5618099", "name": "SH binds SHR within the HSP90 chaperone complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5618094", "species_10473503" ], "products": [ "species_10473342" ], "modifiers": [], "additional_components": [ "species_193057", "species_469662", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "species_113592", "Q8WS79", "FBgn0035849", "P02828", "FBgn0001233", "Q8WS79", "FBgn0035849", "CHEBI:16973", "species_193977", "CHEBI:27584", "species_193055", "species_193057", "species_193079", "species_469662", "CHEBI:29117", "Q9VH95", "FBgn0037728", "species_113592" ] }, "reaction_10498428": { "compartment": "compartment_7660", "id": "reaction_10498428", "reactome": "R-DME-9668902", "name": "Formation of the CTF18-RFC(7s) complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427600", "species_10438451", "species_10427605", "species_10427610", "species_10427615" ], "products": [ "species_10438453" ], "modifiers": [], "additional_components": [ "FBgn0032244", "Q2PDX2", "FBgn0054001", "Q8IQ05", "FBgn0015376", "Q4V3Z5", "FBgn0034495", "FBgn0030871", "FBgn0028700", "FBgn0260985", "P53034", "FBgn0260985", "Q9U9Q1", "FBgn0028700", "Q9VX15", "FBgn0030871", "Q2PDX2", "FBgn0054001", "Q8IQ05", "FBgn0015376", "Q4V3Z5", "FBgn0034495", "Q9VKW3", "FBgn0032244" ] }, "reaction_10498430": { "compartment": "compartment_7660", "id": "reaction_10498430", "reactome": "R-DME-9668904", "name": "Formation of the CTF18 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438449", "species_10438439", "species_10438444" ], "products": [ "species_10438451" ], "modifiers": [], "additional_components": [ "FBgn0034495", "FBgn0015376", "FBgn0054001", "Q2PDX2", "FBgn0054001", "Q8IQ05", "FBgn0015376", "Q4V3Z5", "FBgn0034495" ] }, "reaction_10442443": { "compartment": "compartment_70101", "id": "reaction_10442443", "reactome": "R-DME-204647", "name": "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_204635", "species_10442429", "species_29360" ], "products": [ "species_70106", "species_204628", "species_10442425", "species_73473" ], "modifiers": [ [ "species_10442438", "catalyst" ] ], "additional_components": [ "FBgn0285952", "FBgn0285952", "Q9VSF4", "FBgn0035854" ] }, "reaction_10442458": { "compartment": "compartment_70101", "id": "reaction_10442458", "reactome": "R-DME-204662", "name": "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_29368", "species_10442425", "species_73473" ], "products": [ "species_29356", "species_10442446", "species_29360" ], "modifiers": [ [ "species_10442455", "catalyst" ] ], "additional_components": [ "FBgn0285952", "FBgn0285952", "Q9V9U4", "FBgn0261479", "species_111793" ] }, "reaction_10445932": { "compartment": "compartment_12045", "id": "reaction_10445932", "reactome": "R-DME-381087", "name": "Dimerization of PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445921" ], "products": [ "species_10445930" ], "modifiers": [], "additional_components": [ "FBgn0037327", "Q9NIV1", "FBgn0037327" ] }, "reaction_10445957": { "compartment": "compartment_70101", "id": "reaction_10445957", "reactome": "R-DME-381111", "name": "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10430457" ], "products": [ "species_10445954", "species_29370" ], "modifiers": [ [ "species_10445930", "catalyst" ] ], "additional_components": [ "P41374", "FBgn0261609", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "Q24208", "FBgn0263740", "P41375", "FBgn0004926", "P41374", "FBgn0261609", "Q9NIV1", "FBgn0037327" ] }, "reaction_10476175": { "compartment": "compartment_70101", "id": "reaction_10476175", "reactome": "R-DME-5676966", "name": "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5687536", "species_71284" ], "products": [ "species_5687529", "species_71285" ], "modifiers": [ [ "species_10476172", "catalyst" ] ], "additional_components": [ "FBgn0086768" ] }, "reaction_10476167": { "compartment": "compartment_70101", "id": "reaction_10476167", "reactome": "R-DME-5676917", "name": "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_5676932" ], "products": [ "species_10430994", "species_174390" ], "modifiers": [ [ "species_10476162", "catalyst" ] ], "additional_components": [ "FBgn0040070", "FBgn0040070", "FBgn0267376" ] }, "reaction_10461449": { "compartment": "compartment_70101", "id": "reaction_10461449", "reactome": "R-DME-1799332", "name": "Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10461443", "species_10461445" ], "products": [ "species_10461447" ], "modifiers": [], "additional_components": [ "Q9VSS2", "FBgn0035947", "P49963", "FBgn0015298", "Q9VSC1", "FBgn0035827", "Q9VDL0", "FBgn0038808", "Q9VDK7", "FBgn0038810", "Q9V3D9", "FBgn0010747", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VSS2", "FBgn0035947", "P49963", "FBgn0015298", "Q9VSC1", "FBgn0035827", "Q9VDL0", "FBgn0038808", "Q9VDK7", "FBgn0038810", "Q9V3D9", "FBgn0010747" ] }, "reaction_10494849": { "compartment": "compartment_70101", "id": "reaction_10494849", "reactome": "R-DME-8952620", "name": "NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493819", "species_10494824", "species_10493698" ], "products": [ "species_10494826" ], "modifiers": [], "additional_components": [ "Q9VUQ8", "FBgn0036510", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510" ] }, "reaction_10495201": { "compartment": "compartment_70101", "id": "reaction_10495201", "reactome": "R-DME-8956040", "name": "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495188" ], "products": [ "species_10495198", "species_10477768" ], "modifiers": [ [ "species_10489634", "catalyst" ] ], "additional_components": [ "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "A1ZBY1", "FBgn0034542", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9VJ33", "FBgn0032725", "Q9VAQ0", "FBgn0039632", "Q7JWH5", "FBgn0044020", "Q9VVB4", "FBgn0036671", "Q9VUQ8", "FBgn0036510", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9V9R2", "FBgn0032956", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "A1ZBY1", "FBgn0034542", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "Q9VAQ0", "FBgn0039632", "Q7JWH5", "FBgn0044020", "FBgn0032725", "Q9VVU5", "FBgn0027057", "Q94899", "FBgn0013746", "Q8SYG2", "FBgn0027055", "Q9V345", "FBgn0027054", "Q9XZ58", "FBgn0027053", "Q9VCY3", "FBgn0028837", "Q7KTH8", "FBgn0261437", "Q9V4S8", "FBgn0028836" ] }, "reaction_10494949": { "compartment": "compartment_7660", "id": "reaction_10494949", "reactome": "R-DME-8952638", "name": "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494922" ], "products": [ "species_10494924", "species_10494946" ], "modifiers": [ [ "species_10494922", "catalyst" ] ], "additional_components": [ "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "FBgn0035853", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9VJ33", "FBgn0032725", "Q5BI50", "FBgn0033260", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853" ] }, "reaction_10495238": { "compartment": "compartment_70101", "id": "reaction_10495238", "reactome": "R-DME-8956140", "name": "NEDD8 and UBD bind NUB1 and the 26S proteasome", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427203", "species_10477768", "species_10495234" ], "products": [ "species_10495236" ], "modifiers": [], "additional_components": [ "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "FBgn0032725", "FBgn0039343", "Q9VBQ3", "FBgn0039343", "Q9VJ33", "FBgn0032725", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_10494951": { "compartment": "compartment_7660", "id": "reaction_10494951", "reactome": "R-DME-8952639", "name": "NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494920", "species_10494855", "species_10494912" ], "products": [ "species_10494922" ], "modifiers": [], "additional_components": [ "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853" ] }, "reaction_10495208": { "compartment": "compartment_7660", "id": "reaction_10495208", "reactome": "R-DME-8956045", "name": "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494946" ], "products": [ "species_10495205", "species_10495203" ], "modifiers": [ [ "species_10477930", "catalyst" ] ], "additional_components": [ "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9VJ33", "FBgn0032725", "Q5BI50", "FBgn0033260", "Q9XYZ5", "FBgn0260962", "Q9VVB4", "FBgn0036671", "Q9VVB4", "FBgn0036671", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "FBgn0032725", "Q9V345", "FBgn0027054", "Q7KTH8", "FBgn0261437", "Q8SYG2", "FBgn0027055", "Q9VCY3", "FBgn0028837", "Q9V4S8", "FBgn0028836", "Q94899", "FBgn0013746", "Q9XZ58", "FBgn0027053", "Q9VVU5", "FBgn0027057" ] }, "reaction_10495240": { "compartment": "compartment_70101", "id": "reaction_10495240", "reactome": "R-DME-8956184", "name": "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495236" ], "products": [ "species_10427203", "species_10495234" ], "modifiers": [], "additional_components": [ "Q9VBQ3", "FBgn0039343", "Q9VJ33", "FBgn0032725", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3", "FBgn0039343" ] }, "reaction_10495242": { "compartment": "compartment_876", "id": "reaction_10495242", "reactome": "R-DME-8956200", "name": "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494842", "species_10494824" ], "products": [ "species_10494844" ], "modifiers": [], "additional_components": [ "FBgn0033784", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q8T8S1", "FBgn0033784" ] }, "reaction_10493675": { "compartment": "compartment_70101", "id": "reaction_10493675", "reactome": "R-DME-8951644", "name": "Release of mature NEDD8", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10477770" ], "products": [ "species_10477768", "species_10477759" ], "modifiers": [], "additional_components": [ "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288", "Q9VJ33", "FBgn0032725", "FBgn0032725", "Q9VRE9", "FBgn0031157", "P35122", "FBgn0010288" ] }, "reaction_10495122": { "compartment": "compartment_70101", "id": "reaction_10495122", "reactome": "R-DME-8955241", "name": "CAND1 binds cytosolic CRL E3 ubiquitin ligases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495118", "species_10477966" ], "products": [ "species_10495120" ], "modifiers": [], "additional_components": [ "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "A1ZBY1", "FBgn0034542", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "Q9VAQ0", "FBgn0039632", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q7JWH5", "FBgn0044020", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "Q9V9R2", "FBgn0032956", "FBgn0027568", "Q9VKY2", "FBgn0027568", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VMR4", "FBgn0016920", "Q9VUW0", "FBgn0036549", "Q9VQI1", "FBgn0031473", "Q9VA06", "FBgn0086704", "Q9W112", "FBgn0035059", "A1ZBY1", "FBgn0034542", "Q9VPY3", "FBgn0031317", "A1Z6E0", "FBgn0026238", "Q8INY1", "FBgn0041184", "Q9VAQ0", "FBgn0039632", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q7JWH5", "FBgn0044020", "Q9VDH3", "FBgn0038839", "Q9VUU5", "FBgn0040230", "P05084", "FBgn0001180", "Q9VNZ4", "FBgn0037120", "A8JQX6", "FBgn0037876", "Q9VJL7", "FBgn0028895", "A1ZAV3", "FBgn0034240", "Q9VHJ6", "FBgn0286204", "Q7K0L2", "FBgn0030114", "A0A4D6K4X9", "FBgn0035708", "Q7KSF5", "FBgn0038475", "Q9VR80", "FBgn0031098", "Q04652", "FBgn0001301", "Q8IP45", "FBgn0261268", "Q9VFD5", "FBgn0038286", "Q9I7J2", "FBgn0038488", "Q9V3C1", "FBgn0041174", "Q9V9R2", "FBgn0032956" ] }, "reaction_10495219": { "compartment": "compartment_70101", "id": "reaction_10495219", "reactome": "R-DME-8956099", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495215", "species_10495210" ], "products": [ "species_10495217" ], "modifiers": [], "additional_components": [ "FBgn0031664", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q7K4I5", "FBgn0031664" ] }, "reaction_10495223": { "compartment": "compartment_70101", "id": "reaction_10495223", "reactome": "R-DME-8956103", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458032", "species_10495210" ], "products": [ "species_10495221" ], "modifiers": [], "additional_components": [ "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411" ] }, "reaction_10495128": { "compartment": "compartment_7660", "id": "reaction_10495128", "reactome": "R-DME-8955245", "name": "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494894", "species_10495124" ], "products": [ "species_10495126" ], "modifiers": [], "additional_components": [ "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962", "FBgn0027568", "Q9VKY2", "FBgn0027568", "Q5BI50", "FBgn0033260", "Q9W5E1", "Roc1a", "Q9V3J8", "FBgn0040066", "Q9VAT2", "FBgn0039601", "Q7K7W5", "FBgn0000057", "Q9VPH8", "FBgn0036973", "Q9V9T1", "FBgn0250755", "Q8IP73", "FBgn0051855", "Q24371", "FBgn0013548", "Q9W091", "FBgn0035268", "Q7JYQ4", "FBgn0034527", "Q9VR53", "FBgn0266848", "Q9VUN7", "FBgn0036500", "Q24572", "FBgn0263979", "Q9XYZ5", "FBgn0260962" ] }, "reaction_10495228": { "compartment": "compartment_70101", "id": "reaction_10495228", "reactome": "R-DME-8956106", "name": "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495221", "species_10458091" ], "products": [ "species_10495225", "species_10427563" ], "modifiers": [ [ "species_10495221", "catalyst" ], [ "species_10495217", "inhibitor" ] ], "additional_components": [ "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411", "Q9Y165", "FBgn0027609", "P25867", "eff", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q24167", "FBgn0266411", "Q9V3C1", "FBgn0041174", "O44226", "FBgn0023212", "Q7JWD6", "FBgn0266711", "Q9V9R2", "FBgn0032956", "Q9VJ33", "FBgn0032725", "Q9VVB4", "FBgn0036671", "Q9W5E1", "Roc1a", "Q7K4I5", "FBgn0031664" ] }, "reaction_10494846": { "compartment": "compartment_70101", "id": "reaction_10494846", "reactome": "R-DME-8952618", "name": "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494826" ], "products": [ "species_10493677", "species_10494838" ], "modifiers": [ [ "species_10494826", "catalyst" ], [ "species_10494844", "inhibitor" ] ], "additional_components": [ "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510", "FBgn0035853", "Q24311", "Cul1", "Q9VJ33", "FBgn0032725", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VVB4", "FBgn0036671", "Q9VUQ8", "FBgn0036510", "Q9VJ33", "FBgn0032725", "Q9VSF3", "FBgn0035853", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q9VUQ8", "FBgn0036510", "Q9VVB4", "FBgn0036671", "Q24311", "Cul1", "O77430", "SkpA", "Q9VIK3", "FBgn0032878", "Q9VPY2", "FBgn0024314", "Q9VMY0", "FBgn0031652", "A8DYA6", "FBgn0033639", "Q9VF10", "FBgn0038385", "Q9VMI1", "FBgn0031773", "Q9VY46", "FBgn0030555", "Q8SX44", "FBgn0053969", "Q9VAZ0", "FBgn0039554", "Q7YZ95", "FBgn0037236", "Q9VYW5", "FBgn0030320", "Q9VTM4", "FBgn0036196", "Q9VH60", "FBgn0037760", "Q9VTL8", "FBgn0052085", "Q9VU65", "FBgn0036354", "Q9VG61", "FBgn0038056", "Q9W5E1", "Roc1a", "Q8T8S1", "FBgn0033784" ] }, "reaction_10489264": { "compartment": "compartment_984", "id": "reaction_10489264", "reactome": "R-DME-8855711", "name": "PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8855720", "species_10489260" ], "products": [ "species_10489262" ], "modifiers": [], "additional_components": [ "M9NE79", "FBgn0262357", "Q9VPS2", "FBgn0040107", "M9PB26", "FBgn0264341", "Q9VQ53", "FBgn0031373", "Q59DY5", "FBgn0053533", "Q9VQU4", "FBgn0040104", "Q59DY6", "FBgn0053532", "Q9VQX3", "FBgn0040102", "Q7JY62", "FBgn0040092", "Q9W3D8", "FBgn0030050", "A1Z7Z6", "FBgn0040093", "Q8IRH8", "FBgn0035199", "A1Z8L7", "FBgn0040503", "Q9VIX1", "FBgn0016675", "B4ZJ93", "FBgn0259958", "Q9VKL8", "FBgn0040096", "B7YZU7", "FBgn0259230", "Q9VLM0", "FBgn0040098", "B7Z0K3", "FBgn0038315", "Q9VM16", "FBgn0031910", "C3KGN2", "FBgn0283508", "Q9VPS1", "FBgn0040106", "M9NE79", "FBgn0262357", "Q9VPS2", "FBgn0040107", "M9PB26", "FBgn0264341", "Q9VQ53", "FBgn0031373", "Q59DY5", "FBgn0053533", "Q9VQU4", "FBgn0040104", "Q59DY6", "FBgn0053532", "Q9VQX3", "FBgn0040102", "Q7JY62", "FBgn0040092", "Q9W3D8", "FBgn0030050", "A1Z7Z6", "FBgn0040093", "Q8IRH8", "FBgn0035199", "A1Z8L7", "FBgn0040503", "Q9VIX1", "FBgn0016675", "B4ZJ93", "FBgn0259958", "Q9VKL8", "FBgn0040096", "B7YZU7", "FBgn0259230", "Q9VLM0", "FBgn0040098", "B7Z0K3", "FBgn0038315", "Q9VM16", "FBgn0031910", "C3KGN2", "FBgn0283508", "Q9VPS1", "FBgn0040106", "species_8855720" ] }, "reaction_10488819": { "compartment": "compartment_70101", "id": "reaction_10488819", "reactome": "R-DME-8853379", "name": "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10457705" ], "products": [ "species_8853371", "species_8853381" ], "modifiers": [ [ "species_10488816", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "species_8853396", "CHEBI:91284", "CHEBI:91283", "CHEBI:91282", "CHEBI:91281", "FBgn0030839" ] }, "reaction_10488392": { "compartment": "compartment_70101", "id": "reaction_10488392", "reactome": "R-DME-8850594", "name": "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10457705" ], "products": [ "species_1022114", "species_8852852" ], "modifiers": [ [ "species_10488389", "catalyst" ] ], "additional_components": [ "CHEBI:60627", "CHEBI:60628", "species_915149", "CHEBI:60629", "species_964740", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "CHEBI:60628", "CHEBI:60629", "species_964740", "species_915149", "CHEBI:60627", "Q9VQ57", "FBgn0267972", "Q7KN62", "FBgn0286784", "Q9VCD5", "FBgn0039147", "Q9V3W9", "FBgn0026777", "Q7KRR5", "FBgn0033050", "Q9VSC5", "FBgn0035830", "P48601", "Rpt2" ] }, "reaction_10454410": { "compartment": "compartment_17957", "id": "reaction_10454410", "reactome": "R-DME-901047", "name": "Binding of ERp57", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454406", "species_10453353" ], "products": [ "species_10454408" ], "modifiers": [], "additional_components": [ "P29413", "FBgn0005585", "Q9I7S9", "FBgn0030377", "Q9VXF6", "FBgn0264077", "Q9VAL7", "FBgn0015622", "CHEBI:59080", "FBgn0033663", "Q3YMU0", "FBgn0033663", "P29413", "FBgn0005585", "Q9I7S9", "FBgn0030377", "Q9VXF6", "FBgn0264077", "Q9VAL7", "FBgn0015622", "CHEBI:59080" ] }, "reaction_10455485": { "compartment": "compartment_17963", "id": "reaction_10455485", "reactome": "R-DME-964759", "name": "Alternative endo-mannosidase I route", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_964754" ], "products": [ "species_964744", "species_964746" ], "modifiers": [ [ "species_10455482", "catalyst" ] ], "additional_components": [ "FBgn0031716" ] }, "reaction_10455493": { "compartment": "compartment_20699", "id": "reaction_10455493", "reactome": "R-DME-964768", "name": "Addition of GlcNAc to the glycan on the A arm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_914003", "species_964740" ], "products": [ "species_964837", "species_205687" ], "modifiers": [ [ "species_10455490", "catalyst" ] ], "additional_components": [ "FBgn0034521" ] }, "reaction_10478044": { "compartment": "compartment_70101", "id": "reaction_10478044", "reactome": "R-DME-5693061", "name": "STAMBP binds STAM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10439062", "species_10478040" ], "products": [ "species_10478042" ], "modifiers": [], "additional_components": [ "FBgn0027363", "FBgn0039773", "Q9VA71", "FBgn0039773", "Q9XTL2", "FBgn0027363" ] }, "reaction_10479159": { "compartment": "compartment_70101", "id": "reaction_10479159", "reactome": "R-DME-5696547", "name": "STAMBPL1 is a deubiquitinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437507" ], "products": [ "species_10437505" ], "modifiers": [ [ "species_10479156", "catalyst" ], [ "species_10478042", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "FBgn0039773", "Q9VA71", "FBgn0039773", "Q9XTL2", "FBgn0027363" ] }, "reaction_10477973": { "compartment": "compartment_70101", "id": "reaction_10477973", "reactome": "R-DME-5691431", "name": "PSMD14 cleaves K63-linked ubiquitin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437507" ], "products": [ "species_10437505" ], "modifiers": [ [ "species_10426995", "catalyst" ] ], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558" ] }, "reaction_10435837": { "compartment": "compartment_17957", "id": "reaction_10435837", "reactome": "R-DME-159761", "name": "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_6806362", "species_159751", "species_10435823" ], "products": [ "species_113519", "species_10435829", "species_6806366" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10435960": { "compartment": "compartment_17957", "id": "reaction_10435960", "reactome": "R-DME-159803", "name": "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10435952", "species_6806362", "species_159751" ], "products": [ "species_113519", "species_6806366", "species_10435958" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10436711": { "compartment": "compartment_17957", "id": "reaction_10436711", "reactome": "R-DME-163820", "name": "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_6806362", "species_159751", "species_10436703" ], "products": [ "species_113519", "species_10436709", "species_6806366" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10435926": { "compartment": "compartment_17957", "id": "reaction_10435926", "reactome": "R-DME-159795", "name": "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_6806362", "species_10435924", "species_159751" ], "products": [ "species_113519", "species_6806366", "species_10435863" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10435970": { "compartment": "compartment_17957", "id": "reaction_10435970", "reactome": "R-DME-159819", "name": "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113534", "species_10435968", "species_6806362", "species_159751" ], "products": [ "species_113519", "species_6806366", "species_10435815" ], "modifiers": [ [ "species_10435834", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0035245" ] }, "reaction_10436719": { "compartment": "compartment_20699", "id": "reaction_10436719", "reactome": "R-DME-163843", "name": "Furin cleaves pro-GAS6 to GAS6", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436695" ], "products": [ "species_10436715", "species_10436717" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "FBgn0027594", "FBgn0027594", "FBgn0027594", "FBgn0004509" ] }, "reaction_10435946": { "compartment": "compartment_20699", "id": "reaction_10435946", "reactome": "R-DME-159796", "name": "Furin cleaves pro-factor IX to factor IX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435932" ], "products": [ "species_10435938", "species_10435944" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10435801": { "compartment": "compartment_20699", "id": "reaction_10435801", "reactome": "R-DME-159733", "name": "Furin cleaves pro-factor X to factor X", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435779" ], "products": [ "species_10435793", "species_10435787" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10435895": { "compartment": "compartment_20699", "id": "reaction_10435895", "reactome": "R-DME-159771", "name": "Furin cleaves pro-protein C to protein C", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435877" ], "products": [ "species_10435893", "species_10435887" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10436677": { "compartment": "compartment_20699", "id": "reaction_10436677", "reactome": "R-DME-163798", "name": "Furin cleaves pro-protein Z to protein Z", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10436663" ], "products": [ "species_10436675", "species_10436669" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10435986": { "compartment": "compartment_20699", "id": "reaction_10435986", "reactome": "R-DME-159868", "name": "Furin cleaves pro-factor VII to factor VII", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435901" ], "products": [ "species_10435984", "species_10435978" ], "modifiers": [ [ "species_10435798", "catalyst" ] ], "additional_components": [ "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "FBgn0004509" ] }, "reaction_10480016": { "compartment": "compartment_12045", "id": "reaction_10480016", "reactome": "R-DME-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6788753", "species_71284" ], "products": [ "species_71285", "species_6788758" ], "modifiers": [ [ "species_10480013", "catalyst" ] ], "additional_components": [ "Q9VU37", "FBgn0036336", "species_1562550" ] }, "reaction_10494803": { "compartment": "compartment_17957", "id": "reaction_10494803", "reactome": "R-DME-8952289", "name": "FAM20C phosphorylates FAM20C substrates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10494300", "species_8931885" ], "products": [ "species_10494796", "species_8931884" ], "modifiers": [ [ "species_10494300", "catalyst" ], [ "species_10494801", "catalyst" ] ], "additional_components": [ "A4VCL2", "FBgn0051145", "P54399", "FBgn0286818", "Q9V4B8", "FBgn0051999", "P98163", "FBgn0004649", "Q9VP10", "FBgn0037105", "Q9VTZ5", "FBgn0036299", "Q9VJW9", "FBgn0259984", "Q9VLC3", "FBgn0032116", "Q9VX11", "FBgn0052557", "Q9VBK7", "FBgn0039387", "Q9VM47", "FBgn0031885", "Q9V416", "FBgn0028879", "P14599", "FBgn0000108", "Q9VVK3", "FBgn0052183", "Q9VHA8", "FBgn0037718", "Q9VUH4", "FBgn0036446", "Q9VUH5", "FBgn0036447", "Q9VDT9", "FBgn0014135", "Q9VMA7", "FBgn0286898", "Q9VUX3", "FBgn0044028", "P27091", "FBgn0024234", "P54631", "FBgn0005590", "Q9V4E6", "FBgn0039914", "P07713", "FBgn0000490", "Q9VVK7", "FBgn0052190", "Q9V438", "FBgn0025678", "E1JI03", "FBgn0036449", "Q9W302", "FBgn0030163", 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"Q9VJW9", "FBgn0259984", "Q9VLC3", "FBgn0032116", "Q9VX11", "FBgn0052557", "Q9VBK7", "FBgn0039387", "Q9VM47", "FBgn0031885", "Q9V416", "FBgn0028879", "P14599", "FBgn0000108", "Q9VVK3", "FBgn0052183", "Q9VHA8", "FBgn0037718", "Q9VUH4", "FBgn0036446", "Q9VUH5", "FBgn0036447", "Q9VDT9", "FBgn0014135", "Q9VMA7", "FBgn0286898", "Q9VUX3", "FBgn0044028", "P27091", "FBgn0024234", "P54631", "FBgn0005590", "Q9V4E6", "FBgn0039914", "P07713", "FBgn0000490", "Q9VVK7", "FBgn0052190", "Q9V438", "FBgn0025678", "E1JI03", "FBgn0036449", "Q9W302", "FBgn0030163", "A1Z7G6", "FBgn0033312", "B7Z0B2", "FBgn0035452", "Q7KT80", "FBgn0051832", "Q8IRM2", "FBgn0030164", "Q95SM8", "FBgn0050281", "Q9VME7", "FBgn0031804", "Q9VX04", "FBgn0030880", "Q9VLT3", "FBgn0267488", "Q9VLY7", "FBgn0041181", "M9PDR0", "FBgn0041180", "Q9NFV7", "FBgn0041182", "Q9NFV8", "FBgn0041183", "Q9VJD1", "FBgn0032643", "Q9VTJ4", "FBgn0285958", "Q9W0A0", "FBgn0027594", "Q7K508", "FBgn0033574", "Q7K8Y5", "FBgn0265137", "Q7KA66", "FBgn0024294", "Q7YTY6", "FBgn0028988", "Q8SYY7", "FBgn0044011", "Q8SZF4", "FBgn0033115", "Q9V3N1", "Spn27A", "Q9VA48", "FBgn0039795", "Q9VFC1", "FBgn0038299", "Q9VFC2", "FBgn0028984", "Q9VH46", "FBgn0037772", "Q9VII7", "FBgn0028986", "Q9VL44", "FBgn0032178", "Q9VLQ7", "FBgn0028987", "Q9VLU4", "FBgn0031973", "Q9VLV3", "FBgn0053121", "Q9VLZ8", "FBgn0083141", "Q9VPH9", "FBgn0036970", "Q9VVW1", "FBgn0015586", "Q9VWB4", "FBgn0036969", "A1Z6I3", "FBgn0263109", "A1Z6R3", "FBgn0033112", "A1Z6R4", "FBgn0033113", "A1Z6V5", "FBgn0024293", "Q0E8C8", "FBgn0262057", "Q0E8V6", "FBgn0051902", "Q3HKQ3", "FBgn0052203", "Q4V3G2", "FBgn0034195", "Q7JV69", "FBgn0028983", "Q7JWX3", "FBgn0002930", "Q24114", "dally", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "O97365", "FBgn0026562", "P11046", "FBgn0261800", "Q7JQR3", "FBgn0033814", "Q9VWV6", "FBgn0022355", "Q9VAY2", "FBgn0039562", "Q9VH14", "FBgn0025879", "P15215", "FBgn0267348", "P49415", "FBgn0010415", "X2JEB0", "FBgn0262730", "Q9W0H8", "FBgn0025682", "Q9VJB6", "FBgn0262018", "Q8IMZ9", "FBgn0039003", "Q9VPI6", "FBgn0031213", "Q9VPI7", "FBgn0031214", "Q9VPU6", "FBgn0031289", "A4VCL2", "FBgn0051145" ] }, "reaction_10444863": { "compartment": "compartment_876", "id": "reaction_10444863", "reactome": "R-DME-374922", "name": "Noradrenalin synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10444851", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10444853" ], "modifiers": [ [ "species_10444851", "catalyst" ] ], "additional_components": [ "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964" ] }, "reaction_10444858": { "compartment": "compartment_984", "id": "reaction_10444858", "reactome": "R-DME-374899", "name": "Release of noradrenaline at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444853" ], "products": [ "species_10443025", "species_10442919", "species_10444855", "species_10443003", "species_10443019", "species_10442973", "species_374935", "species_10443023" ], "modifiers": [ [ "species_10444853", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0004574", "FBgn0260964", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_351597", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343" ] }, "reaction_10444371": { "compartment": "compartment_374932", "id": "reaction_10444371", "reactome": "R-DME-372542", "name": "Loading of dopamine into synaptic veiscles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_159362" ], "products": [ "species_351601" ], "modifiers": [ [ "species_10444368", "catalyst" ] ], "additional_components": [ "FBgn0260964" ] }, "reaction_10496500": { "compartment": "compartment_70101", "id": "reaction_10496500", "reactome": "R-DME-9013869", "name": "DDX41 binds bacterial c-di-AMP, c-di-GMP ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8982080", "species_10467519" ], "products": [ "species_10496498" ], "modifiers": [], "additional_components": [ "CHEBI:49537", "CHEBI:47037", "FBgn0015331", "Q9V3C0", "FBgn0015331", "CHEBI:49537", "CHEBI:47037" ] }, "reaction_10468991": { "compartment": "compartment_7660", "id": "reaction_10468991", "reactome": "R-DME-3788725", "name": "Cdh1:APC/C complex binds EHMT1:EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468978", "species_10438214" ], "products": [ "species_10468980" ], "modifiers": [], "additional_components": [ "M9PGH7", "FBgn0040372", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "M9PGH7", "FBgn0040372" ] }, "reaction_10468989": { "compartment": "compartment_7660", "id": "reaction_10468989", "reactome": "R-DME-3788724", "name": "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468980", "species_10427430" ], "products": [ "species_10468986" ], "modifiers": [ [ "species_10468980", "catalyst" ] ], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "M9PGH7", "FBgn0040372", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "P18101", "UBI-P63E 12", "Q9W418", "FBgn0086558", "P0CG69", "UBI-P63E 1", "P15357", "UBI-P63E 11", "M9PGH7", "FBgn0040372", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "M9PGH7", "FBgn0040372" ] }, "reaction_10468969": { "compartment": "compartment_7660", "id": "reaction_10468969", "reactome": "R-DME-3788708", "name": "CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10438214", "species_10427405" ], "products": [ "species_10438216" ], "modifiers": [ [ "species_10439439", "inhibitor" ] ], "additional_components": [ "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107" ] }, "reaction_10469079": { "compartment": "compartment_7660", "id": "reaction_10469079", "reactome": "R-DME-3857336", "name": "CEBPB homodimerization", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10469061" ], "products": [ "species_10469063" ], "modifiers": [], "additional_components": [ "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493" ] }, "reaction_10468966": { "compartment": "compartment_7660", "id": "reaction_10468966", "reactome": "R-DME-3788705", "name": "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10438216" ], "products": [ "species_113582", "species_10438218" ], "modifiers": [ [ "species_10438216", "catalyst" ], [ "species_10439439", "inhibitor" ] ], "additional_components": [ "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "P23573", "FBgn0004107", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q9W4H9", "FBgn0262699", "P23573", "FBgn0004107", "Q9W4H9", "FBgn0262699", "Q9VCN6", "FBgn0025781", "Q9VZL2", "FBgn0041147", "Q9W395", "FBgn0052707", "Q9VS37", "FBgn0012058", "Q9W1E5", "FBgn0002791", "Q9Y165", "FBgn0027609", "P25867", "eff", "Q9VXV3", "FBgn0004391", "Q9VX25", "FBgn0030863", "P52485", "FBgn0015320", "Q9VTY6", "FBgn0264848", "Q7KA43", "FBgn0250903", "Q9V831", "FBgn0034231", "Q9I7L8", "FBgn0032863", "Q9W3Y6", "FBgn0029879", "Q7JNL9", "FBgn0010316", "P23573", "FBgn0004107" ] }, "reaction_10469077": { "compartment": "compartment_7660", "id": "reaction_10469077", "reactome": "R-DME-3857329", "name": "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10469069" ], "products": [ "species_113582", "species_10469075" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "Q9VK13", "FBgn0032493", "Q02637", "FBgn0005638", "Q02637", "FBgn0005638", "Q9VK13", "FBgn0032493", "P40417", "FBgn0003256" ] }, "reaction_10447725": { "compartment": "compartment_876", "id": "reaction_10447725", "reactome": "R-DME-420980", "name": "Activation of Ca permeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10446959", "catalyst" ] ], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_10447723": { "compartment": "compartment_984", "id": "reaction_10447723", "reactome": "R-DME-420977", "name": "Ca permeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10446957" ], "products": [ "species_10446959" ], "modifiers": [], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_10447721": { "compartment": "compartment_984", "id": "reaction_10447721", "reactome": "R-DME-420975", "name": "Ca impermeable AMPA receptor ligand binding", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_210382", "species_10446946" ], "products": [ "species_10446948" ], "modifiers": [], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_10446951": { "compartment": "compartment_876", "id": "reaction_10446951", "reactome": "R-DME-399711", "name": "Activation of Ca impermeable AMPA receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10446948", "catalyst" ] ], "additional_components": [ "M9PHV5", "FBgn0264000", "Q9VVU7", "FBgn0036829", "Q9VVL2", "FBgn0261401", "Q9VVL1", "FBgn0036757", "Q9VRL4", "FBgn0035604", "Q9VIA5", "FBgn0037501", "Q03445", "FBgn0004619", "species_210382" ] }, "reaction_350405": { "compartment": "compartment_876", "id": "reaction_350405", "reactome": "R-DME-350405", "name": "RHOGEF2 binds to RHO1:GDP complex at the plasma membrane", "reversible": "false", "notes": "At the plasma membrane, Rho guanyl-nucleotide exchange factor (RHOGEF2) associates with the inactive Rho GTPase complex (RHO1:GDP).", "reactants": [ "species_350999", "species_350951" ], "products": [ "species_351056" ], "modifiers": [], "additional_components": [ "species_29420", "P48148", "Rho1", "O44113", "RHOGEF2", "species_29420", "P48148", "Rho1" ] }, "reaction_350453": { "compartment": "compartment_70101", "id": "reaction_350453", "reactome": "R-DME-350453", "name": "RHOGAPP190 binds to RHO1:GTP complex at the plasma membrane", "reversible": "false", "notes": "Rho GTPase activator (RHOGAPP190) associates with the activated Rho GTPase complex (RHO1:GTP) at the plasma membrane.", "reactants": [ "species_350991", "species_350950" ], "products": [ "species_351000" ], "modifiers": [], "additional_components": [ "species_29438", "P48148", "Rho1", "species_29438", "P48148", "Rho1", "Q9VX32", "RhoGAPp190" ] }, "reaction_350359": { "compartment": "compartment_70101", "id": "reaction_350359", "reactome": "R-DME-350359", "name": "RHO1:GDP complex dissociates from RHOGDI and binds to the plasma membrane", "reversible": "false", "notes": "Inactive Rho GTPase complex (RHO1:GDP) dissociates from Rho GDP dissociation inhibitor (RHOGDI) and binds to the plasma membrane.", "reactants": [ "species_351058" ], "products": [ "species_351008", "species_350999" ], "modifiers": [], "additional_components": [ "Q9VW59", "RhoGDI", "species_29420", "P48148", "Rho1", "species_29420", "P48148", "Rho1" ] }, "reaction_350450": { "compartment": "compartment_876", "id": "reaction_350450", "reactome": "R-DME-350450", "name": "RHO1:GTP complex dissociates from RHOGEF2", "reversible": "false", "notes": "Rho guanyl-nucleotide exchange factor (RHOGEF2) dissociates from the activated Rho GTPase complex (RHO1:GTP).", "reactants": [ "species_351086" ], "products": [ "species_350950", "species_350951" ], "modifiers": [], "additional_components": [ "O44113", "RHOGEF2", "species_29438", "P48148", "Rho1", "species_29438", "P48148", "Rho1" ] }, "reaction_350477": { "compartment": "compartment_70101", "id": "reaction_350477", "reactome": "R-DME-350477", "name": "RHOGEF2 stimulates nucleotide exchange of RHO1:GDP complex", "reversible": "false", "notes": "Rho guanyl-nucleotide exchange factor (RHOGEF2) catalyses GTP for GDP nucleotide exchange with the Rho GTPase complex (RHO1:GDP).", "reactants": [ "species_29438", "species_351056" ], "products": [ "species_29420", "species_351086" ], "modifiers": [ [ "species_351056", "catalyst" ] ], "additional_components": [ "O44113", "RHOGEF2", "species_29420", "P48148", "Rho1", "O44113", "RHOGEF2", "species_29438", "P48148", "Rho1", "O44113", "RHOGEF2", "species_29420", "P48148", "Rho1" ] }, "reaction_350395": { "compartment": "compartment_70101", "id": "reaction_350395", "reactome": "R-DME-350395", "name": "RHOGDI binds to and sequesters RHO1:GDP complex to the cytosol", "reversible": "false", "notes": "Rho GDP dissociation inhibitor (RHOGDI) sequesters inactive Rho GTPase complex (RHO1:GDP) in the cytosol.", "reactants": [ "species_351008", "species_350999" ], "products": [ "species_351058" ], "modifiers": [], "additional_components": [ "species_29420", "P48148", "Rho1", "Q9VW59", "RhoGDI", "species_29420", "P48148", "Rho1" ] }, "reaction_350458": { "compartment": "compartment_70101", "id": "reaction_350458", "reactome": "R-DME-350458", "name": "RHOGAPP190 activates GTP hydrolysis by RHO1:GTP", "reversible": "false", "notes": "RHOGAPP190 activates the GTPase activity of RHO1, leading to hydrolysis of its bound GTP.", "reactants": [ "species_351000" ], "products": [ "species_29372", "species_351009" ], "modifiers": [ [ "species_351000", "catalyst" ] ], "additional_components": [ "species_29438", "P48148", "Rho1", "Q9VX32", "RhoGAPp190", "species_29420", "P48148", "Rho1", "Q9VX32", "RhoGAPp190", "species_29438", "P48148", "Rho1", "Q9VX32", "RhoGAPp190" ] }, "reaction_350410": { "compartment": "compartment_70101", "id": "reaction_350410", "reactome": "R-DME-350410", "name": "RHO1:GDP complex dissociates from RHOGAPP190", "reversible": "false", "notes": "Rho GTPase activator (RHOGAPP190) dissociates from inactive Rho GTPase complex(RHO1:GDP).", "reactants": [ "species_351009" ], "products": [ "species_350991", "species_350999" ], "modifiers": [], "additional_components": [ "species_29420", "P48148", "Rho1", "Q9VX32", "RhoGAPp190", "species_29420", "P48148", "Rho1" ] }, "reaction_10470223": { "compartment": "compartment_70101", "id": "reaction_10470223", "reactome": "R-DME-4793925", "name": "p-S303,307-HSF1 binds YWHAE (14-3-3)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432016", "species_10470219" ], "products": [ "species_10470221" ], "modifiers": [], "additional_components": [ "P92177", "14-3-3epsilon", "FBgn0001222", "P22813", "FBgn0001222", "P92177", "14-3-3epsilon" ] }, "reaction_10471487": { "compartment": "compartment_70101", "id": "reaction_10471487", "reactome": "R-DME-5252079", "name": "HSP110s exchange ATP for ADP on HSP70s:ADP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10471418" ], "products": [ "species_29370", "species_10471276" ], "modifiers": [ [ "species_10471470", "catalyst" ], [ "species_10471485", "inhibitor" ] ], "additional_components": [ "species_29370", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "M9MSL3", "FBgn0026418", "A8JNS4", "FBgn0086708", "Q95RY2", "FBgn0036505", "Q86DS1", "FBgn0029676", "C4NYP8", "FBgn0260484" ] }, "reaction_10471450": { "compartment": "compartment_70101", "id": "reaction_10471450", "reactome": "R-DME-5252041", "name": "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471278" ], "products": [ "species_10471354" ], "modifiers": [ [ "species_10432243", "catalyst" ] ], "additional_components": [ "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9W0C7", "FBgn0035243", "Q9W0C7", "FBgn0035243", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "species_113592", "A1Z8P9", "FBgn0013756", "Q9I7N3", "FBgn0042127", "Q9I7N2", "FBgn0042125", "Q9VBU8", "FBgn0039301", "Q9VCW3", "FBgn0039004", "Q7K2X8", "FBgn0033247", "Q9VCH5", "FBgn0039120", "Q9V466", "FBgn0027868", "Q9V3J4", "FBgn0024509", "A1YK02", "FBgn0034310", "Q9VE85", "FBgn0038609", "Q9VKJ3", "FBgn0262647", "Q9W2E7", "FBgn0034646", "Q9GYU8", "FBgn0026207", "Q9VCG4", "FBgn0039125", "Q8IQV9", "FBgn0031078", "Q9VWS2", "FBgn0030943", "Q9VFE7", "FBgn0038274", "Q9V463", "FBgn0021761", "A1Z6H7", "FBgn0266580", "Q7K0D8", "FBgn0033264", "Q9W1X4", "FBgn0010660", "Q9W351", "FBgn0030122", "Q9V6B9", "FBgn0033737", "Q7JXF5", "FBgn0034118", "Q9VDV3", "FBgn0038722", "Q9VXE6", "FBgn0061200" ] }, "reaction_10470217": { "compartment": "compartment_70101", "id": "reaction_10470217", "reactome": "R-DME-4793911", "name": "MAPKAPK2 phosphorylates HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468527" ], "products": [ "species_29370", "species_10470214" ], "modifiers": [ [ "species_10439409", "catalyst" ] ], "additional_components": [ "FBgn0001222", "FBgn0001222", "FBgn0013987" ] }, "reaction_10471528": { "compartment": "compartment_7660", "id": "reaction_10471528", "reactome": "R-DME-5333051", "name": "RPA1 binds HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10427667", "species_10468620" ], "products": [ "species_10471526" ], "modifiers": [], "additional_components": [ "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421", "P22813", "FBgn0001222", "P22813", "FBgn0001222", "Q24492", "FBgn0010173", "Q9VIH1", "FBgn0032906", "Q9VYW3", "FBgn0266421" ] }, "reaction_10471429": { "compartment": "compartment_70101", "id": "reaction_10471429", "reactome": "R-DME-5251959", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10471276" ], "products": [ "species_29372", "species_10471418" ], "modifiers": [ [ "species_10471426", "catalyst" ] ], "additional_components": [ "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_29370", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9VP77", "FBgn0037051", "A8DYF7", "FBgn0034091", "Q9V3W1", "FBgn0032586" ] }, "reaction_10468628": { "compartment": "compartment_70101", "id": "reaction_10468628", "reactome": "R-DME-3371531", "name": "Constitutive phosphorylation by pERK1/2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468527" ], "products": [ "species_10468626", "species_29370" ], "modifiers": [ [ "species_10458636", "catalyst" ] ], "additional_components": [ "FBgn0001222", "FBgn0001222", "P40417", "FBgn0003256" ] }, "reaction_10468532": { "compartment": "compartment_70101", "id": "reaction_10468532", "reactome": "R-DME-3371435", "name": "Constitutive phosphorylation by GSK3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10468527" ], "products": [ "species_10468530", "species_29370" ], "modifiers": [ [ "species_10440540", "catalyst" ] ], "additional_components": [ "FBgn0001222", "FBgn0001222", "P83101", "FBgn0046332", "P18431", "sgg" ] }, "reaction_10471396": { "compartment": "compartment_7660", "id": "reaction_10471396", "reactome": "R-DME-5251955", "name": "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113518", "species_10471354" ], "products": [ "species_113550", "species_10471376", "species_10471352" ], "modifiers": [ [ "species_10471393", "catalyst" ] ], "additional_components": [ "Q9W0C7", "FBgn0035243", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "species_113592", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "species_29370", "FBgn0035243", "Q9V3W1", "FBgn0032586", "Q9VP77", "FBgn0037051", "A8DYF7", "FBgn0034091" ] }, "reaction_10471280": { "compartment": "compartment_70101", "id": "reaction_10471280", "reactome": "R-DME-5251942", "name": "Hikeshi binds HSP70s:ATP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10471200", "species_10471276" ], "products": [ "species_10471278" ], "modifiers": [], "additional_components": [ "FBgn0035243", "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "species_113592", "P02825", "FBgn0013276", "Q8INI8", "FBgn0013277", "Q9VG58", "FBgn0051354", "O97125", "FBgn0001230", "P82910", "FBgn0013275", "Q9BIS2", "FBgn0013278", "P11146", "FBgn0001217", "Q9BIR7", "FBgn0013279", "Q9VSI1", "FBgn0035878", "Q9W0C7", "FBgn0035243" ] }, "reaction_10498679": { "compartment": "compartment_7660", "id": "reaction_10498679", "reactome": "R-DME-9699579", "name": "AKT phosphorylates FOXO3 downstream of FLT3 ", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10441099" ], "products": [ "species_113582", "species_10441113" ], "modifiers": [ [ "species_10441086", "catalyst" ] ], "additional_components": [] }, "reaction_10497384": { "compartment": "compartment_70101", "id": "reaction_10497384", "reactome": "R-DME-9607304", "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10475840", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "E1JHB7", "FBgn0032006", "Q9VJ04", "FBgn0032752", "P26675", "Sos" ] }, "reaction_10454271": { "compartment": "compartment_70101", "id": "reaction_10454271", "reactome": "R-DME-879914", "name": "IL3 stimulation induces Vav binding to Tec kinase", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442646", "species_10442471" ], "products": [ "species_10454269" ], "modifiers": [], "additional_components": [ "FBgn0003502", "FBgn0040068", "Q9NHV9", "FBgn0040068", "P08630", "FBgn0003502" ] }, "reaction_10454509": { "compartment": "compartment_70101", "id": "reaction_10454509", "reactome": "R-DME-912790", "name": "CBL binds CRK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454432", "species_10446146" ], "products": [ "species_10454503" ], "modifiers": [], "additional_components": [ "FBgn0020224", "FBgn0024811", "Q9XYM0", "FBgn0024811", "Q9VSK2", "FBgn0020224" ] }, "reaction_10454507": { "compartment": "compartment_70101", "id": "reaction_10454507", "reactome": "R-DME-912734", "name": "CBL:CRKL binds RAPGEF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446160", "species_10454503" ], "products": [ "species_10454505" ], "modifiers": [], "additional_components": [ "FBgn0259228", "Q9XYM0", "FBgn0024811", "Q9VSK2", "FBgn0020224", "Q9XYM0", "FBgn0024811", "Q9VSK2", "FBgn0020224", "O77086", "FBgn0259228" ] }, "reaction_10454281": { "compartment": "compartment_70101", "id": "reaction_10454281", "reactome": "R-DME-879917", "name": "CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10444516", "species_10453140", "species_10439032", "species_10431791" ], "products": [ "species_10454279" ], "modifiers": [], "additional_components": [ "FBgn0262733", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "FBgn0020224", "FBgn0004638", "Q08012", "FBgn0004638", "Q9VSK2", "FBgn0020224", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P00528", "FBgn0262733" ] }, "reaction_10454501": { "compartment": "compartment_70101", "id": "reaction_10454501", "reactome": "R-DME-912727", "name": "CBL binds VAV", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454432", "species_10442471" ], "products": [ "species_10454499" ], "modifiers": [], "additional_components": [ "FBgn0020224", "FBgn0040068", "Q9NHV9", "FBgn0040068", "Q9VSK2", "FBgn0020224" ] }, "reaction_10454497": { "compartment": "compartment_70101", "id": "reaction_10454497", "reactome": "R-DME-912627", "name": "CBL ubiquitinates PI3K", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454480", "species_10454434" ], "products": [ "species_10454495" ], "modifiers": [], "additional_components": [ "P0CG69", "UBI-P63E 1", "P18101", "UBI-P63E 12", "P15357", "UBI-P63E 11", "Q9W418", "FBgn0086558", "Q08012", "FBgn0004638", "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622", "P00528", "FBgn0262733", "Q9VSK2", "FBgn0020224", "Q08012", "FBgn0004638", "Q7KTZ2", "FBgn0020622", "P91634", "Pi3K92E", "P00528", "FBgn0262733", "Q9VSK2", "FBgn0020224" ] }, "reaction_10495825": { "compartment": "compartment_70101", "id": "reaction_10495825", "reactome": "R-DME-8987218", "name": "p-STAT1 dimer translocates from the cytosol to the nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495805" ], "products": [ "species_10495823" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495817": { "compartment": "compartment_70101", "id": "reaction_10495817", "reactome": "R-DME-8987052", "name": "p-STAT3 dimer translocates from cytosol to nucleoplasm", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495811" ], "products": [ "species_10495815" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10495819": { "compartment": "compartment_70101", "id": "reaction_10495819", "reactome": "R-DME-8987214", "name": "p-STAT3 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495809" ], "products": [ "species_10495811" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10495807": { "compartment": "compartment_70101", "id": "reaction_10495807", "reactome": "R-DME-8987007", "name": "p-STAT1 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493643" ], "products": [ "species_10495805" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10450767": { "compartment": "compartment_70101", "id": "reaction_10450767", "reactome": "R-DME-449073", "name": "Caspase-3 cleaves pro-interleukin-16", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450760" ], "products": [ "species_10450762", "species_10450764" ], "modifiers": [ [ "species_10434841", "catalyst" ] ], "additional_components": [ "FBgn0087007", "FBgn0087007", "FBgn0087007", "Q9XYF4", "FBgn0026404" ] }, "reaction_10496506": { "compartment": "compartment_984", "id": "reaction_10496506", "reactome": "R-DME-9014052", "name": "TXLNA (IL14) binds syntaxin3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450776", "species_10496502" ], "products": [ "species_10496504" ], "modifiers": [], "additional_components": [ "FBgn0039379", "FBgn0013343", "Q24547", "FBgn0013343", "Q9VBL3", "FBgn0039379" ] }, "reaction_10450771": { "compartment": "compartment_984", "id": "reaction_10450771", "reactome": "R-DME-449077", "name": "Interleukin-16 is secreted", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10450764" ], "products": [ "species_10450769" ], "modifiers": [], "additional_components": [ "FBgn0087007", "FBgn0087007" ] }, "reaction_10450786": { "compartment": "compartment_984", "id": "reaction_10450786", "reactome": "R-DME-449117", "name": "TXLNA (IL14) binds syntaxin1A", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10450776" ], "products": [ "species_10450778" ], "modifiers": [ [ "species_10450784", "inhibitor" ] ], "additional_components": [ "FBgn0013343", "FBgn0039379", "Q9VBL3", "FBgn0039379", "Q24547", "FBgn0013343", "Q07327", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343" ] }, "reaction_10493651": { "compartment": "compartment_70101", "id": "reaction_10493651", "reactome": "R-DME-8950522", "name": "p-STAT1:p-STAT4 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493647" ], "products": [ "species_10493649" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493665": { "compartment": "compartment_70101", "id": "reaction_10493665", "reactome": "R-DME-8950782", "name": "p-STAT1 binds p-STAT3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457718", "species_10454425" ], "products": [ "species_10457722" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10493659": { "compartment": "compartment_70101", "id": "reaction_10493659", "reactome": "R-DME-8950733", "name": "p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10457722" ], "products": [ "species_10457730" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493640": { "compartment": "compartment_70101", "id": "reaction_10493640", "reactome": "R-DME-8950181", "name": "Y693-STAT4 dimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493634" ], "products": [ "species_10493638" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E", "Q24151", "Stat92E" ] }, "reaction_10493661": { "compartment": "compartment_70101", "id": "reaction_10493661", "reactome": "R-DME-8950778", "name": "p-Y693-STAT4 dimerizes", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10493632" ], "products": [ "species_10493634" ], "modifiers": [], "additional_components": [ "Q24151", "Stat92E" ] }, "reaction_10475576": { "compartment": "compartment_70101", "id": "reaction_10475576", "reactome": "R-DME-5668520", "name": "26Sproteasome degrades K48polyUb-NIK", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10475574" ], "products": [], "modifiers": [ [ "species_10427203", "catalyst" ] ], "additional_components": [ "FBgn0024329", "Q9V3P3", "FBgn0029133", "O18413", "Rpt6", "Q9VUJ1", "Prosbeta2", "Q8T915", "FBgn0037296", "Q9W470", "FBgn0029812", "Q9W414", "FBgn0028685", "Q9V637", "FBgn0033669", "Q9VJJ0", "Prosbeta4", "Q9V3P6", "Rpn2", "Q9XYN7", "Prosbeta3", "Q7KLV9", "Rpn6", "Q9VNA5", "Prosbeta7", "Q9V3Z4", "Rpn5", "Q9V3H2", "Rpn11", "Q7K148", "FBgn0029134", "P22769", "Prosalpha4", "Q27575", "FBgn0017556", "Q24178", "FBgn0265606", "Q7KMP8", "Rpn9", "P12881", "Prosalpha6", "A0AQH0", "FBgn0010590", "Q9VW54", "Rpn1", "P40301", "Prosalpha2", "Q9W1S5", "FBgn0034842", "Q8INY4", "FBgn0051742", "P25161", "Rpn3", "Q9V5C6", "Prosalpha7", "P55035", "Rpn10", "P18053", "FBgn0261394", "Q9VYG1", "FBgn0030457", "Q95083", "Prosalpha5", "Q9V3G7", "Rpn7", "Q9XZJ4", "Prosalpha1", "P26270", "Rpn8", "P48601", "Rpt2", "Q9V436", "Rpn12", "Q7KMQ0", "Rpt1", "P40304", "Prosbeta6", "Q9V3V6", "Rpt5", "Q9VFS8", "FBgn0038166", "Q9V405", "Rpt3" ] }, "reaction_451846": { "compartment": "compartment_70101", "id": "reaction_451846", "reactome": "R-DME-451846", "name": "LFT binds to FT and DS", "reversible": "false", "notes": "The small protein Lowfat (LFT) binds to the cytoplasmic domains of the cadherin domain containing transmembrane proteins Fat (FT) and Dachsous (DS). The function of LFT is currently unknown but it does appear to increase FT and DS protein levels.", "reactants": [ "species_451851", "species_451871" ], "products": [ "species_451879" ], "modifiers": [], "additional_components": [ "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "Q24292", "DS", "P33450", "Phospho FT", "O76324", "DCO", "Q9VKY1", "LFT" ] }, "reaction_451858": { "compartment": "compartment_70101", "id": "reaction_451858", "reactome": "R-DME-451858", "name": "YKI binds to HPO homodimer", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Hippo (HPO) homodimer PPXY sequence motif, of which HPO has one per monomer unit. YKI remains in the cytosol where it is unable to activate its target genes.", "reactants": [ "species_390185", "species_390114" ], "products": [ "species_451843" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q45VV3", "yki", "Q8T0S6", "HPO" ] }, "reaction_451826": { "compartment": "compartment_70101", "id": "reaction_451826", "reactome": "R-DME-451826", "name": "YKI binds to EX", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Expanded (EX) PPXY sequence motif, of which EX has three. YKI remains in the cytosol where it is unable to activate its target genes.", "reactants": [ "species_390114", "species_451874" ], "products": [ "species_451822" ], "modifiers": [], "additional_components": [ "Q07436", "EX", "Q45VV3", "yki" ] }, "reaction_451811": { "compartment": "compartment_70101", "id": "reaction_451811", "reactome": "R-DME-451811", "name": "YKI binds to WTS", "reversible": "false", "notes": "Yorkie (YKI), which has two WW domains, binds to Warts (WTS) PPXY sequence motif, of which WTS has five. YKI remains in the cytosol where it is unable to activate its target genes.", "reactants": [ "species_390114", "species_390037" ], "products": [ "species_451862" ], "modifiers": [], "additional_components": [ "Q9VA38", "WTS", "Q45VV3", "yki" ] }, "reaction_390120": { "compartment": "compartment_70101", "id": "reaction_390120", "reactome": "R-DME-390120", "name": "Phosphorylated HPO dimer phosphorylates TH", "reversible": "false", "notes": "Activated Hippo (HPO) serine/threonine kinase phosphorylates Thread (TH) aka drosophila inhibitor of apoptosis protein 1 (Diap1) at unknown residues. This affects TH's stability.", "reactants": [ "species_113592", "species_390182" ], "products": [ "species_29370", "species_390103" ], "modifiers": [ [ "species_390068", "catalyst" ] ], "additional_components": [ "Q8T0S6", "HPO", "Q95RA8", "MATS", "Q9VA38", "WTS", "Q9VCR6", "SAV" ] }, "reaction_390059": { "compartment": "compartment_70101", "id": "reaction_390059", "reactome": "R-DME-390059", "name": "HPO dimer binds to RASSF", "reversible": "false", "notes": "Ras association family member (RASSF) associates with inactive Hippo (HPO) kinase homodimer through their shared SARAH (Salvador/Rassf/Hippo) domains. It should be noted that Hippo (HPO) kinase domain also associates with scaffolding protein Salvador (SAV) through SARAH domains. However, RASSF fails to bind to SAV. HPO associated with RASSF shows barely detectable levels of phosphorylation. In this complex, HPO homodimer remains unphosphorylated and inactive. Thus, RASSF restricts HPO activity by competing with SAV for binding to HPO homodimer.", "reactants": [ "species_390185", "species_390054" ], "products": [ "species_390177" ], "modifiers": [], "additional_components": [ "Q8T0S6", "HPO", "Q9VCQ7", "RASSF", "Q8T0S6", "HPO" ] }, "reaction_10458089": { "compartment": "compartment_70101", "id": "reaction_10458089", "reactome": "R-DME-1234161", "name": "HIF-alpha translocates from cytosol to nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458077" ], "products": [ "species_10458083" ], "modifiers": [], "additional_components": [ "FBgn0266411", "FBgn0266411" ] }, "reaction_10458148": { "compartment": "compartment_7660", "id": "reaction_10458148", "reactome": "R-DME-1234171", "name": "HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10458083", "species_10458122" ], "products": [ "species_10458124" ], "modifiers": [], "additional_components": [ "FBgn0266411", "FBgn0264075", "O15945", "FBgn0264075", "Q24167", "FBgn0266411" ] }, "reaction_10458130": { "compartment": "compartment_7660", "id": "reaction_10458130", "reactome": "R-DME-1234167", "name": "Formation of HIF:CBP:p300 complex at promoters", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447242", "species_29428", "species_10458124", "species_10458126" ], "products": [ "species_10458128" ], "modifiers": [], "additional_components": [ "FBgn0261617", "O15945", "FBgn0264075", "Q24167", "FBgn0266411", "FBgn0261617", "M9MS40", "FBgn0261617", "O15945", "FBgn0264075", "Q24167", "FBgn0266411" ] }, "reaction_10443099": { "compartment": "compartment_70101", "id": "reaction_10443099", "reactome": "R-DME-210977", "name": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10438980" ], "products": [ "species_29420", "species_10437909" ], "modifiers": [ [ "species_10443096", "catalyst" ] ], "additional_components": [ "P08646", "RAS85D", "species_29420", "species_29438", "P08646", "RAS85D", "Q08012", "FBgn0004638", "Q5BIB8", "FBgn0087011", "Q4V4U2", "FBgn0050280", "P26675", "Sos" ] }, "reaction_10467110": { "compartment": "compartment_876", "id": "reaction_10467110", "reactome": "R-DME-2870221", "name": "E-selectin binds E-selectin ligand", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467106", "species_10467101" ], "products": [ "species_10467108" ], "modifiers": [], "additional_components": [ "FBgn0264561", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "B7YZX0", "FBgn0032797", "A8JUX3", "FBgn0030617", "M9PIG4", "FBgn0264561" ] }, "reaction_10464490": { "compartment": "compartment_876", "id": "reaction_10464490", "reactome": "R-DME-2029471", "name": "Hydrolysis of PC to PA by PLD", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_429802", "species_29356" ], "products": [ "species_264618", "species_1602448" ], "modifiers": [ [ "species_10464487", "catalyst" ] ], "additional_components": [ "B7YZT5", "FBgn0286511" ] }, "reaction_10464470": { "compartment": "compartment_876", "id": "reaction_10464470", "reactome": "R-DME-2029468", "name": "Conversion of PA into DAG by PAP-1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_1602448" ], "products": [ "species_29372", "species_112275" ], "modifiers": [ [ "species_10464465", "catalyst" ] ], "additional_components": [ "FBgn0037341" ] }, "reaction_10464499": { "compartment": "compartment_876", "id": "reaction_10464499", "reactome": "R-DME-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_426925" ], "products": [ "species_140356", "species_428981" ], "modifiers": [ [ "species_10459695", "catalyst" ] ], "additional_components": [ "FBgn0036053" ] }, "reaction_10467643": { "compartment": "compartment_7660", "id": "reaction_10467643", "reactome": "R-DME-3215385", "name": "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467633" ], "products": [ "species_10467640" ], "modifiers": [ [ "species_10467633", "catalyst" ] ], "additional_components": [ "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q7KUZ5", "FBgn0010315", "Q7K306", "FBgn0016131" ] }, "reaction_10467720": { "compartment": "compartment_7660", "id": "reaction_10467720", "reactome": "R-DME-3215448", "name": "SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467716", "species_10467638" ], "products": [ "species_10467718" ], "modifiers": [], "additional_components": [ "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "Q9VKJ1", "FBgn0032348", "Q9VF03", "FBgn0002783", "P25439", "FBgn0000212", "Q24090", "FBgn0011715" ] }, "reaction_10467650": { "compartment": "compartment_7660", "id": "reaction_10467650", "reactome": "R-DME-3215406", "name": "PRMT5 binds WDR77", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467624", "species_10467629" ], "products": [ "species_10467631" ], "modifiers": [ [ "species_10467648", "inhibitor" ] ], "additional_components": [ "FBgn0003978", "FBgn0015925", "Q9U6Y9", "FBgn0015925", "Q9VIP8", "FBgn0003978", "FBgn0015925" ] }, "reaction_10467501": { "compartment": "compartment_7660", "id": "reaction_10467501", "reactome": "R-DME-3132737", "name": "MAPKs phosphorylate ETS1 and ETS2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10467496" ], "products": [ "species_113582", "species_10467499" ], "modifiers": [ [ "species_10440935", "catalyst" ] ], "additional_components": [ "FBgn0003118", "FBgn0003118", "P40417", "FBgn0003256" ] }, "reaction_10476303": { "compartment": "compartment_7660", "id": "reaction_10476303", "reactome": "R-DME-5682020", "name": "MRN complex binds shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432372", "species_3785706" ], "products": [ "species_10476301" ], "modifiers": [], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530" ] }, "reaction_10481055": { "compartment": "compartment_7660", "id": "reaction_10481055", "reactome": "R-DME-6792712", "name": "KAT5 acetylates ATM at shortened telomeres", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113560", "species_10481052" ], "products": [ "species_2485002", "species_10476309" ], "modifiers": [ [ "species_10481052", "catalyst" ] ], "additional_components": [ "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080", "Q9XYZ4", "FBgn0020270", "Q9W252", "FBgn0034728", "Q9VT40", "FBgn0261530", "Q960X4", "FBgn0026080" ] }, "reaction_10454382": { "compartment": "compartment_876", "id": "reaction_10454382", "reactome": "R-DME-888589", "name": "Release of GABA at the synapse", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10454363", "species_74016" ], "products": [ "species_10443025", "species_10454369", "species_10442983", "species_10442919", "species_352003", "species_10454379", "species_10443021", "species_10442973", "species_10454365", "species_10454367", "species_10443023" ], "modifiers": [ [ "species_10454363", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "M9PE32", "FBgn0264606", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0266599", "FBgn0264606", "FBgn0004574", "P20228", "FBgn0004516", "species_74016", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0033911", "FBgn0004179", "FBgn0004242", "Q8IPM8", "FBgn0041605", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "M9PE32", "FBgn0264606", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343" ] }, "reaction_10455094": { "compartment": "compartment_917758", "id": "reaction_10455094", "reactome": "R-DME-917744", "name": "GABA loaded synaptic vesicle Docking and Priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10442978", "species_10442919", "species_10442983", "species_10442968", "species_10454361", "species_10442973" ], "products": [ "species_10454363" ], "modifiers": [ [ "species_10454361", "catalyst" ] ], "additional_components": [ "FBgn0013343", "FBgn0004574", "FBgn0264606", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "FBgn0041605", "Q8IPM8", "FBgn0041605", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "M9PE32", "FBgn0264606", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "A1Z9M6", "FBgn0033911", "P11147", "FBgn0266599", "Q03751", "FBgn0004179", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "species_352011", "P20228", "FBgn0004516" ] }, "reaction_10454328": { "compartment": "compartment_70101", "id": "reaction_10454328", "reactome": "R-DME-888572", "name": "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10454325", "catalyst" ] ], "additional_components": [ "P20228", "FBgn0004516" ] }, "reaction_10454340": { "compartment": "compartment_917757", "id": "reaction_10454340", "reactome": "R-DME-888577", "name": "Synthesis of GABA by GAD2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29404", "species_70106" ], "products": [ "species_352011", "species_113528" ], "modifiers": [ [ "species_10454337", "catalyst" ] ], "additional_components": [ "P20228", "FBgn0004516" ] }, "reaction_10454385": { "compartment": "compartment_70101", "id": "reaction_10454385", "reactome": "R-DME-888592", "name": "Loading of GABA into clathrin sculpted GABA transport vesicle lumen", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_352011" ], "products": [ "species_428571" ], "modifiers": [ [ "species_10454349", "catalyst" ] ], "additional_components": [ "FBgn0033911" ] }, "reaction_10465871": { "compartment": "compartment_70101", "id": "reaction_10465871", "reactome": "R-DME-2465919", "name": "AWAT2 transfers PALM to 11cROL forming 11cRPALM", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431863", "species_200993" ], "products": [ "species_10465860", "species_76194" ], "modifiers": [ [ "species_10465868", "catalyst" ] ], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927", "CHEBI:16254", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q7K1C2", "FBgn0033215", "Q7JYK2", "FBgn0033214", "A1Z739", "FBgn0033216" ] }, "reaction_10465892": { "compartment": "compartment_70101", "id": "reaction_10465892", "reactome": "R-DME-2465971", "name": "RLBP1 binds atROL to form RLBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431861", "species_2473617" ], "products": [ "species_10465890" ], "modifiers": [], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_2473604", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289" ] }, "reaction_10465888": { "compartment": "compartment_70101", "id": "reaction_10465888", "reactome": "R-DME-2465940", "name": "atRAL is reduced to atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_70106", "species_975622", "species_29364" ], "products": [ "species_29366", "species_2473607" ], "modifiers": [ [ "species_10465885", "catalyst" ] ], "additional_components": [ "Q9W3K9", "FBgn0029994", "Q9VR28", "FBgn0031630", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9VCS2", "FBgn0039040", "Q9VCR9", "FBgn0039043" ] }, "reaction_10484702": { "compartment": "compartment_984", "id": "reaction_10484702", "reactome": "R-DME-6799959", "name": "PGLYRP3,4 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10484698" ], "products": [ "species_10484700" ], "modifiers": [ [ "species_158417", "catalyst" ] ], "additional_components": [ "Q9VYX7", "FBgn0030310", "Q9VYX7", "FBgn0030310", "species_6789198" ] }, "reaction_10485860": { "compartment": "compartment_984", "id": "reaction_10485860", "reactome": "R-DME-6801762", "name": "REG3A oligomerize to form a pore complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485854" ], "products": [ "species_10485858" ], "modifiers": [ [ "species_166005", "inhibitor" ] ], "additional_components": [ "CHEBI:62643", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273", "CHEBI:62643", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273" ] }, "reaction_10489510": { "compartment": "compartment_984", "id": "reaction_10489510", "reactome": "R-DME-8862300", "name": "LYZ binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10482357", "species_6789198" ], "products": [ "species_10489508" ], "modifiers": [], "additional_components": [ "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "species_6789198", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539" ] }, "reaction_10489513": { "compartment": "compartment_984", "id": "reaction_10489513", "reactome": "R-DME-8862320", "name": "LYZ hydrolyzes peptidoglycans in the bacterial cell wall", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10489508" ], "products": [ "species_6788991", "species_6788982" ], "modifiers": [ [ "species_10489508", "catalyst" ] ], "additional_components": [ "species_6789198", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539", "species_1236719", "CHEBI:21615", "species_6789198", "A1ZBX6", "FBgn0034538", "A1ZAB8", "FBgn0034092", "A1Z9D5", "FBgn0050062", "Q9W4C2", "FBgn0029765", "Q9VSA5", "FBgn0035813", "Q08694", "FBgn0004425", "P83972", "FBgn0004427", "P83971", "FBgn0004426", "P37161", "FBgn0004431", "P37160", "FBgn0004430", "P37159", "FBgn0004428", "P29615", "FBgn0004429", "A1ZBX7", "FBgn0034539" ] }, "reaction_10486923": { "compartment": "compartment_984", "id": "reaction_10486923", "reactome": "R-DME-6810724", "name": "PI3 binds the bacterial surface", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6803081", "species_10486917" ], "products": [ "species_10486921" ], "modifiers": [], "additional_components": [ "FBgn0039527", "Q9VB21", "FBgn0039527", "species_6803081" ] }, "reaction_10484723": { "compartment": "compartment_984", "id": "reaction_10484723", "reactome": "R-DME-6799981", "name": "PGLYRP2 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10484716" ], "products": [ "species_10484718" ], "modifiers": [], "additional_components": [ "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "species_6789198" ] }, "reaction_10484721": { "compartment": "compartment_984", "id": "reaction_10484721", "reactome": "R-DME-6799977", "name": "PGLYRP2 hydrolyzes bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_109276", "species_10484718" ], "products": [ "species_6799970", "species_10484716", "species_6799975" ], "modifiers": [ [ "species_10484716", "catalyst" ], [ "species_158417", "catalyst" ] ], "additional_components": [ "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "species_6789198", "CHEBI:28881", "species_1678743", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576", "Q9VYX7", "FBgn0030310", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "C0HK98", "FBgn0043576" ] }, "reaction_10489521": { "compartment": "compartment_984", "id": "reaction_10489521", "reactome": "R-DME-8862771", "name": "PLA2G2A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_8931784", "species_10460239" ], "products": [ "species_10489519" ], "modifiers": [], "additional_components": [ "CHEBI:62643", "species_74016", "Q8IML0", "FBgn0039655", "species_74016", "Q8IML0", "FBgn0039655", "CHEBI:62643" ] }, "reaction_10480075": { "compartment": "compartment_1222282", "id": "reaction_10480075", "reactome": "R-DME-6789072", "name": "PGLYRP1 binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_6789198", "species_10480071" ], "products": [ "species_10480073" ], "modifiers": [ [ "species_1562550", "catalyst" ] ], "additional_components": [ "C0HK98", "FBgn0043576", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "Q9VYX7", "FBgn0030310", "C0HK98", "FBgn0043576", "Q9V4X2", "FBgn0043575", "Q0E8V8", "FBgn0035094", "C0HK99", "FBgn0033327", "Q9VYX7", "FBgn0030310", "species_6789198" ] }, "reaction_10485878": { "compartment": "compartment_984", "id": "reaction_10485878", "reactome": "R-DME-6801776", "name": "REG3A binds bacterial phospholipids", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485852", "species_8931784" ], "products": [ "species_10485854" ], "modifiers": [], "additional_components": [ "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273", "CHEBI:62643", "CHEBI:62643", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273" ] }, "reaction_10485882": { "compartment": "compartment_984", "id": "reaction_10485882", "reactome": "R-DME-6801808", "name": "REG3A,REG3G binds bacterial peptidoglycan", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485852", "species_6789198" ], "products": [ "species_10485880" ], "modifiers": [], "additional_components": [ "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273", "species_6789198", "O46197", "FBgn0015583", "Q6GV06", "FBgn0040097", "Q9VPS3", "FBgn0031273" ] }, "reaction_10457859": { "compartment": "compartment_1222282", "id": "reaction_10457859", "reactome": "R-DME-1222491", "name": "Lactoferrin scavenges iron ions", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_2101051", "species_1222611", "species_10457855" ], "products": [ "species_10457857" ], "modifiers": [], "additional_components": [ "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "Q9VWV6", "FBgn0022355", "A1ZAC0", "FBgn0034094", "species_1222611", "species_2101051" ] }, "reaction_10467566": { "compartment": "compartment_70101", "id": "reaction_10467566", "reactome": "R-DME-3204303", "name": "MRE11 binds cytosolic DNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_874088", "species_10467562" ], "products": [ "species_10467564" ], "modifiers": [], "additional_components": [ "FBgn0020270", "Q9XYZ4", "FBgn0020270", "species_874088" ] }, "reaction_10467514": { "compartment": "compartment_70101", "id": "reaction_10467514", "reactome": "R-DME-3134914", "name": "Beta-catenin migrates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10467512" ], "products": [ "species_10467510" ], "modifiers": [], "additional_components": [] }, "reaction_10458430": { "compartment": "compartment_70101", "id": "reaction_10458430", "reactome": "R-DME-1250264", "name": "TXNIP binds reduced thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_10458426" ], "products": [ "species_10458428" ], "modifiers": [], "additional_components": [ "FBgn0040070", "Q9VGU4", "FBgn0037856", "A8JQV1", "FBgn0042105", "Q9I7L1", "FBgn0042104", "Q9VI53", "FBgn0037465", "Q9I7L0", "FBgn0042102", "Q9VI00", "FBgn0037518", "Q9I7K8", "FBgn0042103", "Q9VHZ9", "FBgn0037519", "Q9I7K7", "FBgn0042101", "Q9VHZ8", "FBgn0037520", "Q8SYU5", "FBgn0037517", "Q9VGU7", "FBgn0037853", "Q0E8K8", "FBgn0035103", "Q9VGU4", "FBgn0037856", "A8JQV1", "FBgn0042105", "Q9I7L1", "FBgn0042104", "Q9VI53", "FBgn0037465", "Q9I7L0", "FBgn0042102", "Q9VI00", "FBgn0037518", "Q9I7K8", "FBgn0042103", "Q9VHZ9", "FBgn0037519", "Q9I7K7", "FBgn0042101", "Q9VHZ8", "FBgn0037520", "Q8SYU5", "FBgn0037517", "Q9VGU7", "FBgn0037853", "Q0E8K8", "FBgn0035103", "Q9V429", "FBgn0040070" ] }, "reaction_10458432": { "compartment": "compartment_70101", "id": "reaction_10458432", "reactome": "R-DME-1250280", "name": "ROS oxidize thioredoxin", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10430996", "species_1250243" ], "products": [ "species_10430994" ], "modifiers": [], "additional_components": [ "FBgn0040070", "FBgn0040070" ] }, "reaction_10464323": { "compartment": "compartment_70101", "id": "reaction_10464323", "reactome": "R-DME-2029454", "name": "Autophosphorylation of PAK1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_10446525" ], "products": [ "species_29370", "species_10447061", "species_10446509" ], "modifiers": [ [ "species_10446511", "catalyst" ] ], "additional_components": [ "B7Z0W0", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698", "species_29438", "P40793", "FBgn0010341", "P40792", "RAC1_DROME", "FBgn0267698" ] }, "reaction_10437523": { "compartment": "compartment_984", "id": "reaction_10437523", "reactome": "R-DME-168947", "name": "Ligand binds to TLR10", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_168948", "species_10437517" ], "products": [ "species_10437521" ], "modifiers": [], "additional_components": [ "FBgn0036978", "Q9VPH1", "FBgn0036978" ] }, "reaction_10485986": { "compartment": "compartment_984", "id": "reaction_10485986", "reactome": "R-DME-6804100", "name": "HMGB1 binds LPS", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485978", "species_166005" ], "products": [ "species_10485984" ], "modifiers": [], "additional_components": [ "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979", "species_6803081", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979" ] }, "reaction_10486230": { "compartment": "compartment_984", "id": "reaction_10486230", "reactome": "R-DME-6805981", "name": "HMGB1 release from cells", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10443916" ], "products": [ "species_10485978" ], "modifiers": [], "additional_components": [ "E1JIT5", "FBgn0038979", "Q9VCZ5", "FBgn0038978", "Q24537", "Dsp1", "Q05783", "FBgn0004362", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979" ] }, "reaction_10485982": { "compartment": "compartment_984", "id": "reaction_10485982", "reactome": "R-DME-6804099", "name": "HMGB1 binds LTP", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10485978", "species_181015" ], "products": [ "species_10485980" ], "modifiers": [], "additional_components": [ "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979", "species_181015", "Q05783", "FBgn0004362", "Q24537", "Dsp1", "Q9VCZ5", "FBgn0038978", "E1JIT5", "FBgn0038979" ] }, "reaction_10434118": { "compartment": "compartment_7660", "id": "reaction_10434118", "reactome": "R-DME-111438", "name": "Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10433259", "species_10433230" ], "products": [ "species_10434112" ], "modifiers": [], "additional_components": [ "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "O44437", "FBgn0023167", "Q9VLV5", "FBgn0261790", "Q05856", "FBgn0262601", "Q9VXE0", "FBgn0261791", "A1Z802", "FBgn0033450", "Q24297", "FBgn0000426", "A1Z8C4", "FBgn0033554" ] }, "reaction_390141": { "compartment": "compartment_70101", "id": "reaction_390141", "reactome": "R-DME-390141", "name": "D inhibits WTS", "reversible": "false", "notes": "In the absence of the transmembrane cadherin Fat (FT), the unconventional myosin Dachs (D) accumulates at the plasma membrane where it has access to and inhibits Warts (WTS) kinase.", "reactants": [ "species_390026", "species_390037" ], "products": [ "species_451889", "species_390037" ], "modifiers": [], "additional_components": [ "FBgn0000411", "FBgn0000411" ] }, "reaction_10495859": { "compartment": "compartment_7660", "id": "reaction_10495859", "reactome": "R-DME-9007926", "name": "ATRX binds DAXX", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10495855", "species_10467725" ], "products": [ "species_10495857" ], "modifiers": [], "additional_components": [ "FBgn0026573", "FBgn0031820", "Q9VMD0", "FBgn0031820", "A1Z8R2", "FBgn0026573" ] }, "reaction_10435134": { "compartment": "compartment_984", "id": "reaction_10435134", "reactome": "R-DME-140769", "name": "factor VII -> factor VIIa", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10435117" ], "products": [ "species_10435131" ], "modifiers": [ [ "species_10435079", "catalyst" ] ], "additional_components": [ "species_74016", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "species_74016", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "A1ZAG9", "FBgn0053459", "A1ZAG8", "FBgn0053458", "species_74016" ] }, "reaction_350400": { "compartment": "compartment_70101", "id": "reaction_350400", "reactome": "R-DME-350400", "name": "PK binds to DSH", "reversible": "false", "notes": "The PET/LIM domain of Prickle (PK) interacts with DEP domain and C-terminus of Dishevelled (DSH). The DEP domain is required by DSH for membrane localisation. Binding of Diego (DGO) and PK to DSH is mutually exclusive. PK binding to DSH prevents FZ PCP signalling.", "reactants": [ "species_351050", "species_205749" ], "products": [ "species_351069" ], "modifiers": [], "additional_components": [ "P51140", "phospho-dsh", "A1Z6W3", "PK" ] }, "reaction_350403": { "compartment": "compartment_70101", "id": "reaction_350403", "reactome": "R-DME-350403", "name": "DGO binds to PK", "reversible": "false", "notes": "In the cytosol, Diego (DGO) can bind to Prickle (PK). This may result in there being less DGO to bind to and stabilise the Frizzled (FZ):Dishevelled (DSH) complex.", "reactants": [ "species_351050", "species_351073" ], "products": [ "species_351093" ], "modifiers": [], "additional_components": [ "Q7JUF2", "DGO", "A1Z6W3", "PK" ] }, "reaction_10445880": { "compartment": "compartment_876", "id": "reaction_10445880", "reactome": "R-DME-380905", "name": "Serotonin loaded synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445872", "species_10445808", "species_10442978", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10445874" ], "modifiers": [ [ "species_10445872", "catalyst" ] ], "additional_components": [ "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0013343", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964" ] }, "reaction_10445877": { "compartment": "compartment_984", "id": "reaction_10445877", "reactome": "R-DME-380901", "name": "Release of docked serotonin loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445874" ], "products": [ "species_10445808", "species_10443025", "species_114523", "species_10442919", "species_10444855", "species_10443003", "species_10443019", "species_10442973", "species_10443023" ], "modifiers": [ [ "species_10445874", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0005586", "FBgn0004574", "FBgn0260964", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "Q24547", "FBgn0013343", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "species_114523", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964" ] }, "reaction_10445844": { "compartment": "compartment_374932", "id": "reaction_10445844", "reactome": "R-DME-380586", "name": "loading of Serotonin in synaptic vesicles", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_209914" ], "products": [ "species_380585" ], "modifiers": [ [ "species_10444368", "catalyst" ] ], "additional_components": [ "FBgn0260964" ] }, "reaction_10445870": { "compartment": "compartment_984", "id": "reaction_10445870", "reactome": "R-DME-380869", "name": "Release of docked dopamine loaded synaptic vesicle", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445810" ], "products": [ "species_10445808", "species_10443025", "species_380873", "species_10444855", "species_10442919", "species_10443003", "species_10443019", "species_10442973", "species_10443023" ], "modifiers": [ [ "species_10445810", "catalyst" ] ], "additional_components": [ "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "FBgn0005586", "FBgn0260964", "FBgn0004574", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q24547", "FBgn0013343", "FBgn0041605", "FBgn0004242", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343" ] }, "reaction_10471622": { "compartment": "compartment_70101", "id": "reaction_10471622", "reactome": "R-DME-5336443", "name": "LIN7, CASK and APBA1 bind", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445828", "species_10445833", "species_10445823" ], "products": [ "species_10445839" ], "modifiers": [], "additional_components": [ "FBgn0013759", "FBgn0039269", "X2JE74", "FBgn0026313", "Q9W2S5", "FBgn0052677", "X2JE74", "FBgn0026313", "Q9W2S5", "FBgn0052677", "Q8IMT8", "FBgn0039269", "Q24210", "FBgn0013759" ] }, "reaction_10445841": { "compartment": "compartment_70101", "id": "reaction_10445841", "reactome": "R-DME-380574", "name": "Dopamine synaptic vesicle docking and priming", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10445808", "species_10442978", "species_10445797", "species_10442919", "species_10442968", "species_10443003", "species_10442973" ], "products": [ "species_10445810" ], "modifiers": [ [ "species_10445797", "catalyst" ], [ "species_10445839", "catalyst" ] ], "additional_components": [ "FBgn0013343", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "FBgn0004574", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "FBgn0041605", "Q8IPM8", "FBgn0041605", "H9XVP2", "FBgn0025726", "M9PE32", "FBgn0264606", "M9PCD4", "FBgn0046704", "P36975", "FBgn0011288", "Q9VH76", "FBgn0266720", "Q07327", "FBgn0004574", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "Q24547", "FBgn0013343", "species_380873", "P21521", "FBgn0004242", "P25228", "FBgn0005586", "P18489", "FBgn0003660", "M9PE71", "FBgn0013342", "Q8IH57", "FBgn0260964", "X2JE74", "FBgn0026313", "Q9W2S5", "FBgn0052677", "Q8IMT8", "FBgn0039269", "Q24210", "FBgn0013759" ] }, "reaction_10442917": { "compartment": "compartment_984", "id": "reaction_10442917", "reactome": "R-DME-210420", "name": "Ca2+ influx through voltage gated Ca2+ channels", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10442914", "catalyst" ], [ "species_74126", "inhibitor" ] ], "additional_components": [ "Q9VRE6", "FBgn0064123", "M9PD84", "FBgn0259822", "P91645", "FBgn0263111" ] }, "reaction_10453885": { "compartment": "compartment_984", "id": "reaction_10453885", "reactome": "R-DME-629596", "name": "Binding of acetylcholine to highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10453878", "species_372533" ], "products": [ "species_10453880" ], "modifiers": [], "additional_components": [ "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "P25162", "FBgn0004118", "P17644", "FBgn0000039", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "A0A0S0WNY8", "FBgn0266347", "Q9W3G6", "FBgn0015519", "A0A499GGQ3", "FBgn0028875", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "P25162", "FBgn0004118", "P17644", "FBgn0000039", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "A0A0S0WNY8", "FBgn0266347", "Q9W3G6", "FBgn0015519", "A0A499GGQ3", "FBgn0028875", "species_372533" ] }, "reaction_10453883": { "compartment": "compartment_70101", "id": "reaction_10453883", "reactome": "R-DME-629595", "name": "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74112" ], "products": [ "species_74016" ], "modifiers": [ [ "species_10453880", "catalyst" ] ], "additional_components": [ "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "P25162", "FBgn0004118", "P17644", "FBgn0000039", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "A0A0S0WNY8", "FBgn0266347", "Q9W3G6", "FBgn0015519", "A0A499GGQ3", "FBgn0028875", "species_372533" ] }, "reaction_10453827": { "compartment": "compartment_984", "id": "reaction_10453827", "reactome": "R-DME-629588", "name": "Binding of acetylcholine to highly sodium permeable postsynaptic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10453820", "species_372533" ], "products": [ "species_10453822" ], "modifiers": [], "additional_components": [ "P09478", "FBgn0000036", "P04755", "FBgn0000038", "P25162", "FBgn0004118", "Q9W3G6", "FBgn0015519", "A0A0S0WNY8", "FBgn0266347", "P17644", "FBgn0000039", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261", "species_372533", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "P25162", "FBgn0004118", "Q9W3G6", "FBgn0015519", "A0A0S0WNY8", "FBgn0266347", "P17644", "FBgn0000039", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261" ] }, "reaction_10453825": { "compartment": "compartment_876", "id": "reaction_10453825", "reactome": "R-DME-622325", "name": "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_74113" ], "products": [ "species_83910" ], "modifiers": [ [ "species_10453822", "catalyst" ] ], "additional_components": [ "species_372533", "P09478", "FBgn0000036", "P04755", "FBgn0000038", "P25162", "FBgn0004118", "Q9W3G6", "FBgn0015519", "A0A0S0WNY8", "FBgn0266347", "P17644", "FBgn0000039", "Q9W288", "FBgn0029147", "Q9VPQ8", "FBgn0031261" ] }, "reaction_10455728": { "compartment": "compartment_876", "id": "reaction_10455728", "reactome": "R-DME-975389", "name": "GLRA:GLRB:Gly transports extracellular Cl- to cytosol", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_188972" ], "products": [ "species_352022" ], "modifiers": [ [ "species_10455725", "catalyst" ] ], "additional_components": [ "Q9W4G1", "FBgn0029733", "Q9VVH4", "FBgn0036727", "Q9V9Y4", "FBgn0039840", "Q94900", "FBgn0024963", "M9PI70", "FBgn0264908", "species_29424" ] }, "reaction_350444": { "compartment": "compartment_70101", "id": "reaction_350444", "reactome": "R-DME-350444", "name": "ROK phosphorylates SQH", "reversible": "false", "notes": "Myosin regulatory light chain (MRLC) orthologue Spaghetti Squash (SQH) is phosphorylated at Thr20 and Ser21 by Rho-kinase (ROK). Zipper (ZIP) the myosin heavy chain orthologue would be expected to have its conformation modified and catalytic ativity elevated upon SQH phosphorylation. This leads to cytoskeletal organisation and correct pre-hair orientation.", "reactants": [ "species_113592", "species_351068" ], "products": [ "species_351002", "species_29370" ], "modifiers": [ [ "species_450785", "catalyst" ] ], "additional_components": [ "Q99323", "zip", "P40423", "phospho-sqh", "P54357", "Mlc-c", "Q99323", "zip", "P54357", "Mlc-c", "P40423", "phospho-sqh", "Q9U779", "ROK", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_350362": { "compartment": "compartment_70101", "id": "reaction_350362", "reactome": "R-DME-350362", "name": "ROK phosphorylates MBS", "reversible": "false", "notes": "Myosin binding subunit (MBS) of Myosin phosphatase is phosphorylated at Thr594 by activated Rho-kinase (ROK). Myosin phosphatase is subsequently deactivated.", "reactants": [ "species_351071", "species_113592" ], "products": [ "species_29370", "species_351077" ], "modifiers": [ [ "species_450785", "catalyst" ] ], "additional_components": [ "P48462", "flw", "P12982", "PP1-87B", "Q8IQN4", "Phospho MBS", "P48462", "flw", "P12982", "PP1-87B", "Q8IQN4", "Phospho MBS", "Q9U779", "ROK", "O45030", "VANG", "species_29438", "P48148", "Rho1", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "Q8IRY0", "FBgn0025641" ] }, "reaction_10455221": { "compartment": "compartment_70101", "id": "reaction_10455221", "reactome": "R-DME-927889", "name": "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455216", "species_113592" ], "products": [ "species_10455218", "species_29370" ], "modifiers": [ [ "species_10455216", "catalyst" ] ], "additional_components": [ "O46080", "FBgn0023520", "Q9VKQ6", "FBgn0032296", "Q9VYS3", "FBgn0030354", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "O46080", "FBgn0023520", "Q9VKQ6", "FBgn0032296", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VYS3", "FBgn0030354", "O46080", "FBgn0023520", "Q9VKQ6", "FBgn0032296", "Q9VYS3", "FBgn0030354", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213" ] }, "reaction_10455200": { "compartment": "compartment_70101", "id": "reaction_10455200", "reactome": "R-DME-927836", "name": "SMG6 hydrolyzes mRNA with premature termination codon", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455197" ], "products": [ "species_10455182" ], "modifiers": [ [ "species_10455197", "catalyst" ] ], "additional_components": [ "Q9V414", "FBgn0019890", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VYS3", "FBgn0030354", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q9VBZ6", "FBgn0039260", "P21187", "FBgn0265297", "Q9V414", "FBgn0019890", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q9VYS3", "FBgn0030354", "Q9VBZ6", "FBgn0039260", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9V414", "FBgn0019890", "Q9VK85", "FBgn0020443", "species_29420", "Q9VHC0", "FBgn0037707", "Q9VHS8", "FBgn0037573", "P49028", "FBgn0002736", "Q9V535", "FBgn0033378", "Q9W1H3", "FBgn0034923", "Q9W3L1", "FBgn0029992", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VYS3", "FBgn0030354", "P23696", "mts", "P36872", "tws", "P36179", "Pp2A-29B", "Q9VBZ6", "FBgn0039260" ] }, "reaction_10455156": { "compartment": "compartment_70101", "id": "reaction_10455156", "reactome": "R-DME-927789", "name": "Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10455152", "species_10455132" ], "products": [ "species_10455154" ], "modifiers": [], "additional_components": [ "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VK85", "FBgn0020443", "species_29420", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974", "FBgn0030354", "Q9VYS3", "FBgn0030354", "P21187", "FBgn0265297", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCH1", "FBgn0260634", "A8DZ29", "FBgn0023213", "Q9VK85", "FBgn0020443", "species_29420", "Q7JZW2", "FBgn0034138", "P15357", "UBI-P63E 11", "P41042", "FBgn0011284", "P13008", "FBgn0261597", "C0HKA1", "FBgn0004404", "C0HKA0", "FBgn0004403", "Q9VBU9", "FBgn0039300", "P48588", "FBgn0086472", "Q9W229", "FBgn0261596", "P38979", "FBgn0003517", "Q03334", "FBgn0010265", "Q8T3U2", "FBgn0033912", "P55935", "FBgn0010408", "P80455", "FBgn0286213", "O76927", "FBgn0015521", "Q8MLY8", "FBgn0039713", "Q0E9B6", "FBgn0033699", "P55828", "FBgn0019936", "Q9VA91", "FBgn0039757", "Q9VWG3", "FBgn0285947", "P31009", "FBgn0004867", "P29327", "FBgn0261592", "P48149", "FBgn0010198", "Q24186", "FBgn0002590", "P39018", "FBgn0010412", "P55830", "FBgn0017545", "P41094", "FBgn0010411", "Q06559", "FBgn0002622", "P17704", "FBgn0005533", "Q9VH69", "FBgn0261599", "Q9W237", "FBgn0034743", "Q9W334", "FBgn0030136", "Q9V597", "FBgn0285949", "P04359", "FBgn0002626", "Q9W499", "FBgn0029785", "P19889", "FBgn0000100", "Q9VNB9", "FBgn0037328", "P08570", "FBgn0002593", "P49630", "FBgn0002579", "P05389", "FBgn0003274", "Q9VXX8", "FBgn0030616", "Q9VTP4", "FBgn0036213", "Q9VJY6", "FBgn0032518", "P50887", "FBgn0015288", "Q9VBN5", "FBgn0039359", "Q9VVU2", "FBgn0036825", "P41092", "FBgn0285948", "O16797", "FBgn0020910", "Q9VZS5", "FBgn0035422", "Q9VLT7", "FBgn0031980", "Q24154", "FBgn0016726", "Q9VJ19", "FBgn0086710", "O16130", "FBgn0023170", "Q9V3G1", "FBgn0261602", "Q9VS34", "FBgn0035753", "P50882", "FBgn0015756", "P41093", "FBgn0010409", "P36241", "FBgn0285950", "Q9V9M7", "FBgn0032987", "O61231", "FBgn0024733", "P48159", "FBgn0010078", "Q9W0A8", "FBgn0026372", "P46222", "FBgn0013325", "Q9W5N2", "FBgn0040007", "Q9W1B9", "FBgn0034968", "P09180", "FBgn0003279", "P18101", "UBI-P63E 12", "P41126", "FBgn0011272", "Q9W5R8", "FBgn0064225", "Q9VNE9", "FBgn0037351", "Q9V9W3", "FBgn0039857", "P55841", "FBgn0017579", "P32100", "FBgn0005593", "O17445", "FBgn0028697", "P46223", "FBgn0014026", "Q9W3W8", "FBgn0029897", "Q9VPH7", "FBgn0036974" ] }, "reaction_10429278": { "compartment": "compartment_7660", "id": "reaction_10429278", "reactome": "R-DME-72095", "name": "Internal Methylation of mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10429250" ], "products": [ "species_10429258" ], "modifiers": [ [ "species_10429275", "catalyst" ] ], "additional_components": [ "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P04052", "FBgn0003277", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VCE6", "FBgn0039139", "Q9Y091", "FBgn0000662", "Q9VLP7", "FBgn0032016" ] }, "reaction_10432074": { "compartment": "compartment_7660", "id": "reaction_10432074", "reactome": "R-DME-75082", "name": "ATAC spliceosome mediated Lariat formation,5' splice site cleavage", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432068" ], "products": [ "species_10432068" ], "modifiers": [], "additional_components": [ "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587" ] }, "reaction_10432072": { "compartment": "compartment_7660", "id": "reaction_10432072", "reactome": "R-DME-75081", "name": "Formation of AT-AC B Complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432064", "species_10432054" ], "products": [ "species_10432066" ], "modifiers": [], "additional_components": [ "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786" ] }, "reaction_10432070": { "compartment": "compartment_7660", "id": "reaction_10432070", "reactome": "R-DME-75079", "name": "Formation of AT-AC C complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10432066" ], "products": [ "species_10432068", "species_10432058" ], "modifiers": [], "additional_components": [ "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9VPR5", "FBgn0031266", "Q9VTC1", "FBgn0036104", "Q9W0M7", "FBgn0035162", "Q9VRV7", "FBgn0035692", "Q9VQK7", "FBgn0031493", "Q9VHI4", "FBgn0040534", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426", "Q8IPW7", "FBgn0051922", "Q02427", "FBgn0260944", "Q9V3W7", "FBgn0283477", "P41900", "FBgn0010421", "Q05913", "FBgn0010282", "Q6IGE3", "FBgn0262954", "Q9VC49", "FBgn0039218", "Q9VJE4", "FBgn0032634", "Q9VEA5", "FBgn0263757", "Q9VNZ3", "FBgn0037121", "Q24320", "FBgn0003275", "P08266", "FBgn0262955", "O97183", "FBgn0026373", "P04052", "FBgn0003277", "Q7JZF5", "FBgn0033571", "P36958", "FBgn0004855", "Q9VFB5", "FBgn0051155", "Q7K4N3", "FBgn0022942", "Q9V3L6", "FBgn0022943", "Q9VPL0", "FBgn0031229", "Q9VTW6", "FBgn0036277", "Q9VAX8", "FBgn0039566", "Q8SZ87", "FBgn0031601", "Q9VVU6", "FBgn0036828", "A1Z8U0", "FBgn0033688", "Q9VJ74", "FBgn0032690", "Q9VUV9", "FBgn0263599", "Q9U3Z7", "FBgn0286786", "Q9V3T8", "FBgn0265298", "Q9VR26", "FBgn0031628", "Q95RE4", "FBgn0022959", "P26686", "FBgn0004587", "Q9VLV5", "FBgn0261790", "Q9VU02", "FBgn0261933", "Q05856", "FBgn0262601", "Q9VI10", "FBgn0261789", "Q9VXE0", "FBgn0261791", "O44437", "FBgn0023167", "Q24297", "FBgn0000426" ] }, "reaction_10449034": { "compartment": "compartment_70101", "id": "reaction_10449034", "reactome": "R-DME-429978", "name": "Lsm1-7 Complex binds deadenylated mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448979", "species_429974" ], "products": [ "species_10448981" ], "modifiers": [], "additional_components": [ "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067", "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067" ] }, "reaction_10449015": { "compartment": "compartment_70101", "id": "reaction_10449015", "reactome": "R-DME-429860", "name": "DCP1-DCP2 complex decaps mRNA", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_10448981" ], "products": [ "species_10448983", "species_430004" ], "modifiers": [ [ "species_10449012", "catalyst" ] ], "additional_components": [ "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067", "Q9VJI7", "FBgn0261068", "Q9VTW6", "FBgn0036277", "Q9W2P5", "FBgn0034564", "Q9VRT7", "FBgn0035675", "Q9VKW8", "FBgn0032240", "Q8IMX8", "FBgn0051184", "Q9VEN9", "FBgn0266053", "Q9W2K2", "FBgn0261067", "Q9VKK1", "FBgn0283682", "Q9VVI2", "FBgn0036735", "Q5U127", "FBgn0036534", "Q9W1H5", "FBgn0034921", "P23128", "FBgn0004419" ] }, "reaction_10470317": { "compartment": "compartment_7660", "id": "reaction_10470317", "reactome": "R-DME-5082405", "name": "Phosphorylation of HSF1 at Ser326 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10468620" ], "products": [ "species_113582", "species_10470281" ], "modifiers": [ [ "species_10470314", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "P22813", "FBgn0001222", "Q7JXA2", "FBgn0267824", "Q9W437", "FBgn0029840", "Q9VK45", "FBgn0021796", "Q9W328", "FBgn0264691" ] }, "reaction_10470283": { "compartment": "compartment_7660", "id": "reaction_10470283", "reactome": "R-DME-5082356", "name": "HSF1-mediated gene expression", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470233" ], "products": [ "species_10470271" ], "modifiers": [ [ "species_10470276", "catalyst" ], [ "species_10470281", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "P02517", "FBgn0001225", "P22979", "FBgn0001229", "P02516", "FBgn0001224", "P05812", "FBgn0001227", "P02515", "FBgn0001223", "P02518", "FBgn0001226", "P11146", "FBgn0001217", "P02825", "FBgn0013276", "O97125", "FBgn0001230", "Q9VSI1", "FBgn0035878", "Q9VG58", "FBgn0051354", "Q9BIS2", "FBgn0013278", "Q9BIR7", "FBgn0013279", "Q8INI8", "FBgn0013277", "P82910", "FBgn0013275", "P02828", "FBgn0001233", "Q9VK90", "FBgn0032429", "P11147", "FBgn0266599", "P22813", "FBgn0001222", "P22813", "FBgn0001222" ] }, "reaction_10470298": { "compartment": "compartment_7660", "id": "reaction_10470298", "reactome": "R-DME-5082387", "name": "Phosphorylation of HSF1 at Ser230 induces transactivation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29358", "species_10468620" ], "products": [ "species_113582", "species_10470276" ], "modifiers": [ [ "species_10470295", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "P22813", "FBgn0001222", "Q00168", "FBgn0264607" ] }, "reaction_10468622": { "compartment": "compartment_70101", "id": "reaction_10468622", "reactome": "R-DME-3371527", "name": "HSF1 trimer translocates to the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468616" ], "products": [ "species_10468620" ], "modifiers": [ [ "species_10432016", "inhibitor" ] ], "additional_components": [ "P22813", "FBgn0001222", "P22813", "FBgn0001222", "P92177", "14-3-3epsilon" ] }, "reaction_10470302": { "compartment": "compartment_7660", "id": "reaction_10470302", "reactome": "R-DME-5082391", "name": "Trimerization of HSF1 in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470300" ], "products": [ "species_10468620" ], "modifiers": [], "additional_components": [ "FBgn0001222", "P22813", "FBgn0001222" ] }, "reaction_10468653": { "compartment": "compartment_70101", "id": "reaction_10468653", "reactome": "R-DME-3371591", "name": "Trimerization of cytosolic HSF1", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468527" ], "products": [ "species_10468616" ], "modifiers": [ [ "species_10435578", "catalyst" ] ], "additional_components": [ "FBgn0001222", "P22813", "FBgn0001222", "P08736", "FBgn0284245", "P05303", "FBgn0000557" ] }, "reaction_10470329": { "compartment": "compartment_7660", "id": "reaction_10470329", "reactome": "R-DME-5082409", "name": "Dissociation of HSF1:HSP90 complex in the nucleus", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10470327" ], "products": [ "species_10470325", "species_10470300", "species_10470319" ], "modifiers": [], "additional_components": [ "Q9VH95", "FBgn0037728", "P22813", "FBgn0001222", "P02828", "FBgn0001233", "P02828", "FBgn0001233", "FBgn0001222", "FBgn0037728" ] }, "reaction_10468645": { "compartment": "compartment_70101", "id": "reaction_10468645", "reactome": "R-DME-3371586", "name": "Dissociation of cytosolic HSF1:HSP90 complex", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10468643" ], "products": [ "species_10443622", "species_10468604", "species_10468527" ], "modifiers": [], "additional_components": [ "P22813", "FBgn0001222", "P02828", "FBgn0001233", "Q9VH95", "FBgn0037728", "FBgn0037728", "P02828", "FBgn0001233", "FBgn0001222" ] }, "reaction_10471524": { "compartment": "compartment_70101", "id": "reaction_10471524", "reactome": "R-DME-5324632", "name": "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_5324631", "species_10471519" ], "products": [ "species_10471521", "species_10443622", "species_10468604", "species_10468527" ], "modifiers": [ [ "species_10471519", "catalyst" ] ], "additional_components": [ "P22813", "FBgn0001222", "Q7KN62", "FBgn0286784", "P02828", "FBgn0001233", "M9PJN5", "FBgn0026428", "Q9VH95", "FBgn0037728", "Q7KN62", "FBgn0286784", "M9PJN5", "FBgn0026428", "FBgn0037728", "P02828", "FBgn0001233", "FBgn0001222", "P22813", "FBgn0001222", "Q7KN62", "FBgn0286784", "P02828", "FBgn0001233", "M9PJN5", "FBgn0026428", "Q9VH95", "FBgn0037728" ] }, "reaction_350441": { "compartment": "compartment_70101", "id": "reaction_350441", "reactome": "R-DME-350441", "name": "FLW:MYPT-75D complex dephosphorylates SQH", "reversible": "false", "notes": "Flap wing (FLW) complexed with MYPT-75D dephosphorylates Spaghetti Squash (SQH).", "reactants": [ "species_351064" ], "products": [ "species_29372", "species_351041" ], "modifiers": [ [ "species_351025", "catalyst" ] ], "additional_components": [ "Q8SY34", "MYPT-75D", "P48462", "flw" ] }, "reaction_350475": { "compartment": "compartment_70101", "id": "reaction_350475", "reactome": "R-DME-350475", "name": "FLW:MBS complex dephosphorylates SQH", "reversible": "false", "notes": "Flap wing (FLW) complexed with Myosin binding subunit (MBS) dephosphorylates Spaghetti Squash (SQH).", "reactants": [ "species_351064" ], "products": [ "species_29372", "species_351041" ], "modifiers": [ [ "species_350944", "catalyst" ] ], "additional_components": [ "Q8IQN4", "Phospho MBS", "P48462", "flw" ] }, "reaction_350443": { "compartment": "compartment_70101", "id": "reaction_350443", "reactome": "R-DME-350443", "name": "PP1-87B:MBS complex dephosphorylates SQH", "reversible": "false", "notes": "PP1-87B complexed with Myosin binding subunit (MBS) dephosphorylates Spaghetti Squash (SQH).", "reactants": [ "species_351064" ], "products": [ "species_29372", "species_351041" ], "modifiers": [ [ "species_350963", "catalyst" ] ], "additional_components": [ "Q8IQN4", "Phospho MBS", "P12982", "PP1-87B" ] }, "reaction_450741": { "compartment": "compartment_876", "id": "reaction_450741", "reactome": "R-DME-450741", "name": "VANG, IN, FY, and FRTZ colocalise at the plasma membrane", "reversible": "false", "notes": "In the wing, Van Gogh (VANG) aka Strabismus (Stbm), Inturned (IN), Fuzzy (FY), and Fritz (FRTZ) all colocalise to the proximal side of the plasma membrane.", "reactants": [ "species_450782", "species_450734", "species_450722", "species_450756" ], "products": [ "species_450782", "species_450734", "species_450722", "species_450756" ], "modifiers": [], "additional_components": [ "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK", "O45030", "VANG", "Q7JUF2", "DGO", "P51140", "phospho-dsh", "Q9V5N8", "STAN", "P18537", "FZ", "A1Z6W3", "PK" ] }, "reaction_450770": { "compartment": "compartment_70101", "id": "reaction_450770", "reactome": "R-DME-450770", "name": "MWH binds to RHO1:GTP and is activated", "reversible": "false", "notes": "In the wing, autoinhibited multiple wing hairs (MWH) protein via its GTPase binding domain (GBD) binds to activated RHO1:GTP at the proximal side of the plasma membrane. This relieves the inhibition in MWH and it is now activated. The previously blocked dimerisation domain (DD) is now exposed and able to bind to other formins in a dominant negative manner. The sequestered formins are now unable to promote actin polymerisation around the proximal edge of the cell. It is postulated that the MWH:formin complexes which form in proximity to the developing hair at the distal edge inhibit formation of secondary hairs. There is evidence in the literature that MWH is also phosphorylated by an unknown kinase but definitive proof that this is important for its activity is currently undetermined (Strutt and Warrington, 2008).", "reactants": [ "species_350950", "species_450759" ], "products": [ "species_450755" ], "modifiers": [], "additional_components": [ "species_29438", "P48148", "Rho1", "Q9W0J2", "MWH", "species_29438", "P48148", "Rho1" ] }, "reaction_450802": { "compartment": "compartment_876", "id": "reaction_450802", "reactome": "R-DME-450802", "name": "FZ and VANG bind to STAN homodimer", "reversible": "false", "notes": "The seven-pass transmembrane protein Frizzled (FZ) and the four-pass transmembrane protein Van Gogh (VANG) aka Strabismus (Stbm) bind to opposite ends of the seven-pass transmembrane atypical cadherin Starry Night (STAN) aka Flamingo homodimer. In the case of VANG, this interaction is to the C-terminal domain of STAN. Additionally, there's a possibility of a direct interaction between FZ and VANG.", "reactants": [ "species_205850", "species_351026", "species_351126" ], "products": [ "species_450698" ], "modifiers": [], "additional_components": [ "Q9V5N8", "STAN", "O45030", "VANG", "Q9V5N8", "STAN", "P18537", "FZ" ] }, "reaction_350467": { "compartment": "compartment_70101", "id": "reaction_350467", "reactome": "R-DME-350467", "name": "GUG binds to FT", "reversible": "false", "notes": "The transcriptional repressor Grunge (GUG) aka Atro binds to the intracellular domain of Fat (FT) reinforcing the corresponding strong genetic interaction evidence. GUG like FT is specifically required in the R3 photoreceptor.", "reactants": [ "species_350975", "species_350966" ], "products": [ "species_350926" ], "modifiers": [], "additional_components": [ "P33450", "Phospho FT", "Q24292", "DS", "P33450", "Phospho FT", "Q24292", "DS", "Q9NHX6", "GUG" ] }, "reaction_350377": { "compartment": "compartment_876", "id": "reaction_350377", "reactome": "R-DME-350377", "name": "Extracellular domains of STAN bind to each other in adjacent cells", "reversible": "false", "notes": "The seven-pass transmembrane atypical cadherin Starry Night (STAN) aka Flamingo is known to mediate homophilic protein-protein interaction.", "reactants": [ "species_350928" ], "products": [ "species_351026" ], "modifiers": [], "additional_components": [ "Q9V5N8", "STAN" ] }, "reaction_10441901": { "compartment": "compartment_876", "id": "reaction_10441901", "reactome": "R-DME-202222", "name": "Phosphorylation of PKC theta", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441891", "species_113592" ], "products": [ "species_29370", "species_10441898" ], "modifiers": [ [ "species_10441882", "catalyst" ] ], "additional_components": [ "species_112275", "P83099", "FBgn0259680", "species_112275", "P83099", "FBgn0259680", "species_202247", "species_179838", "Q9W0V1", "Pdk1" ] }, "reaction_10441919": { "compartment": "compartment_70101", "id": "reaction_10441919", "reactome": "R-DME-202354", "name": "Translocation of PLC-gamma1 to PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10441912", "species_179856" ], "products": [ "species_10441917" ], "modifiers": [], "additional_components": [ "FBgn0003416", "species_179856", "Q9VXH3", "FBgn0003416" ] }, "reaction_10441932": { "compartment": "compartment_70101", "id": "reaction_10441932", "reactome": "R-DME-202407", "name": "PLC-gamma1 hydrolyses PIP2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_179856" ], "products": [ "species_114520", "species_112275" ], "modifiers": [ [ "species_10441929", "catalyst" ] ], "additional_components": [ "FBgn0003416" ] }, "reaction_10447468": { "compartment": "compartment_70101", "id": "reaction_10447468", "reactome": "R-DME-418158", "name": "SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447466" ], "products": [ "species_10447466" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733" ] }, "reaction_10447489": { "compartment": "compartment_70101", "id": "reaction_10447489", "reactome": "R-DME-418200", "name": "SRC-1 bound to ARRB2 is not activated", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447487" ], "products": [ "species_10447487" ], "modifiers": [], "additional_components": [ "P40417", "FBgn0003256", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9W2V2", "FBgn0052683", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "P00528", "FBgn0262733" ] }, "reaction_10447473": { "compartment": "compartment_70101", "id": "reaction_10447473", "reactome": "R-DME-418163", "name": "Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10447466" ], "products": [ "species_10447470" ], "modifiers": [ [ "species_10447466", "catalyst" ] ], "additional_components": [ "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733", "P40417", "FBgn0003256", "Q9V393", "krz", "P19107", "FBgn0000121", "P15372", "FBgn0000120", "Q9W2V2", "FBgn0052683", "P00528", "FBgn0262733" ] }, "reaction_10449789": { "compartment": "compartment_70101", "id": "reaction_10449789", "reactome": "R-DME-442314", "name": "VAV3 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449781" ], "products": [ "species_29420", "species_10449783" ], "modifiers": [ [ "species_10449786", "catalyst" ] ], "additional_components": [ "species_29420", "P40792", "RAC1_DROME", "P48148", "Rho1", "P40792", "RAC1_DROME", "P48148", "Rho1", "species_29438", "FBgn0040068" ] }, "reaction_10435017": { "compartment": "compartment_70101", "id": "reaction_10435017", "reactome": "R-DME-114689", "name": "PLC gamma 2-mediated PIP2 hydrolysis", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_179856" ], "products": [ "species_114520", "species_114519" ], "modifiers": [ [ "species_10435014", "catalyst" ] ], "additional_components": [ "FBgn0003416" ] }, "reaction_10449704": { "compartment": "compartment_70101", "id": "reaction_10449704", "reactome": "R-DME-437162", "name": "PI3K alpha, beta, gamma convert PIP2 to PIP3", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_113592", "species_179856" ], "products": [ "species_179838", "species_29370" ], "modifiers": [ [ "species_10431820", "catalyst" ] ], "additional_components": [ "P91634", "Pi3K92E", "Q7KTZ2", "FBgn0020622" ] }, "reaction_10448868": { "compartment": "compartment_876", "id": "reaction_10448868", "reactome": "R-DME-429497", "name": "SLP-76 stimulates PLC gamma 2", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10448866" ], "products": [ "species_10435014" ], "modifiers": [], "additional_components": [ "FBgn0003416", "FBgn0003416" ] }, "reaction_10449763": { "compartment": "compartment_70101", "id": "reaction_10449763", "reactome": "R-DME-442273", "name": "VAV1 is a GEF for Rho/Rac family GTPases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449751" ], "products": [ "species_29420", "species_10449753" ], "modifiers": [ [ "species_10449756", "catalyst" ], [ "species_10449761", "catalyst" ], [ "species_10449759", "inhibitor" ] ], "additional_components": [ "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29420", "P40792", "RAC1_DROME", "P48554", "FBgn0014011", "species_29438", "FBgn0040068", "Q9NHV9", "FBgn0040068", "species_179838", "species_179856", "Q9NHV9", "FBgn0040068" ] }, "reaction_10449777": { "compartment": "compartment_70101", "id": "reaction_10449777", "reactome": "R-DME-442291", "name": "VAV2 is a GEF for Rho/Rac family kinases", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29438", "species_10449769" ], "products": [ "species_29420", "species_10449771" ], "modifiers": [ [ "species_10449774", "catalyst" ] ], "additional_components": [ "P48148", "Rho1", "species_29420", "P48148", "Rho1", "species_29438", "FBgn0040068" ] }, "reaction_10446140": { "compartment": "compartment_876", "id": "reaction_10446140", "reactome": "R-DME-381750", "name": "Olfactory Receptor - G Protein olfactory trimer complex formation", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10446099", "species_10446067" ], "products": [ "species_10446101" ], "modifiers": [ [ "species_10446138", "catalyst" ] ], "additional_components": [ "Q4LBB9", "FBgn0038063", "P41596", "FBgn0011582", "Q9NFZ3", "FBgn0267252", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "P26308", "FBgn0001105", "Q4LBB9", "FBgn0038063", "P41596", "FBgn0011582", "Q9NFZ3", "FBgn0267252", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "P26308", "FBgn0001105", "Q9W1J5", "FBgn0034907" ] }, "reaction_10446069": { "compartment": "compartment_876", "id": "reaction_10446069", "reactome": "R-DME-381749", "name": "G Protein trimer formation (olfactory)", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10437306", "species_10437738", "species_10434556" ], "products": [ "species_10446067" ], "modifiers": [], "additional_components": [ "FBgn0001105", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "FBgn0267252", "Q9NFZ3", "FBgn0267252", "Q05337", "FBgn0010223", "P20354", "FBgn0001123", "P26308", "FBgn0001105" ] }, "reaction_10465838": { "compartment": "compartment_70101", "id": "reaction_10465838", "reactome": "R-DME-2453833", "name": "RPE65 isomero-hydrolyses atREs to 11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_29356", "species_2864099" ], "products": [ "species_30927", "species_2864103", "species_70106" ], "modifiers": [ [ "species_10465830", "catalyst" ], [ "species_10465836", "catalyst" ] ], "additional_components": [ "CHEBI:70762", "species_2534407", "CHEBI:70760", "CHEBI:70761", "CHEBI:16196", "CHEBI:17351", "species_3632881", "species_8934421", "FBgn0002937", "FBgn0000317" ] }, "reaction_10465854": { "compartment": "compartment_70101", "id": "reaction_10465854", "reactome": "R-DME-2454264", "name": "11cROL binds to RLBP1 to form RLBP1:11cROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_30927", "species_10431861" ], "products": [ "species_10431863" ], "modifiers": [], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927" ] }, "reaction_10431900": { "compartment": "compartment_12045", "id": "reaction_10431900", "reactome": "R-DME-74872", "name": "RDH10,11 oxidise 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431863", "species_29366" ], "products": [ "species_70106", "species_10431865", "species_29364" ], "modifiers": [ [ "species_10431897", "catalyst" ] ], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927", "species_8960974", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q9VCR9", "FBgn0039043", "Q9VKB8", "FBgn0032405", "Q9VIG6", "FBgn0032910", "Q9W3K9", "FBgn0029994", "Q9VCS2", "FBgn0039040", "Q9VR28", "FBgn0031630" ] }, "reaction_10465852": { "compartment": "compartment_12045", "id": "reaction_10465852", "reactome": "R-DME-2454081", "name": "RDH5 oxidises 11cROL to 11cRAL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431863", "species_29360" ], "products": [ "species_70106", "species_10431865", "species_73473" ], "modifiers": [ [ "species_10465841", "catalyst" ] ], "additional_components": [ "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "species_30927", "species_8960974", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "FBgn0000056" ] }, "reaction_10495347": { "compartment": "compartment_70101", "id": "reaction_10495347", "reactome": "R-DME-8960973", "name": "RLBP1:11cRAL dissociates", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431865" ], "products": [ "species_10431861", "species_8960974" ], "modifiers": [], "additional_components": [ "species_8960974", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289", "Q9VRP8", "FBgn0035636", "Q9VTY1", "FBgn0036289" ] }, "reaction_10431849": { "compartment": "compartment_70101", "id": "reaction_10431849", "reactome": "R-DME-74843", "name": "atROL binds RBP1 to form RBP1:atROL", "reversible": "false", "notes": "This event has been computationally inferred from an event that has been demonstrated in another species.The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "reactants": [ "species_10431845", "species_2473604" ], "products": [ "species_10431847" ], "modifiers": [], "additional_components": [ "FBgn0037913", "species_2473604", "Q8INK3", "FBgn0037913" ] } }, "mod_collapsed_pathways": {}, "degree_dictionary": { "reaction_10497653": 3, "species_10434387": 25, "species_74016": 102, "P49258": 36, "FBgn0011273": 1, "Q9VMT2": 36, "FBgn0031692": 1, "P48593": 36, "FBgn0004910": 1, "Q9VDI3": 36, "FBgn0038830": 1, "P47949": 36, "FBgn0010424": 1, "Q9VBM1": 36, "FBgn0039373": 1, "P47948": 36, "FBgn0010423": 1, "Q9VBM0": 36, "FBgn0039374": 1, "P47947": 36, "FBgn0013348": 1, "Q7K860": 36, "FBgn0033027": 1, "A1Z777": 36, "FBgn0050378": 1, "P62152": 36, "FBgn0000253": 1, "Q9W2L0": 36, "FBgn0034592": 1, "species_10497649": 2, "FBgn0016126": 2, "species_10497651": 16, "Q7JMV3": 2, "reaction_10435736": 6, "species_10435730": 5, "Q9V3E7": 21, "FBgn0010774": 3, "Q9U1H9": 12, "FBgn0003321": 3, 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